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BCL2   (Danio rerio)

Description [+]
  • Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Pisces; Danio rerio
  • Short gene description: Bcl2 (B-cell leukemia/lymphoma 2). [Source:UniProtKB/TrEMBL;Acc:Q564A4]
  • Family: Bcl-2 family : multidomain Bcl-2
  • Process: apoptosis,
  • Pathways: intrinsic pathway, pre-mitochondrial signaling events,
  • Criteria: manually curated
  • Curator comment: Ectopic expression of Bcl2 in zebrafish embryos inhibits apoptosis induced by multiple stimuli including death receptors [16888647], ectopic expression of several pro-apoptotic Bcl2 family members [16888646], and gamma-irradiation [16888646]. full-length zebrafish bcl2 protein binds strongly to the BH3 domain peptide from zebrafish bim, binds weakly to bida, bad, and bbc3, and does not bind at all to pmaip1 [18404156]. Zebrafish Bcl2 promotes survival following growth factor withdrawal in murine FL5.12 cells and binds directly to human Bim, Bax, and Puma in this context [18510930].
  • Human ortholog(s): BCL2
  • WIKI: BCL2-D_rerio
References [+]
Structure & Sequence [+]
Evolution [+]
Gene Ontology [+]
KEGG Pathways [+]
Information from other databases [+]