PRDX4 (Homo sapiens)
Description [+]
- Synonyms: PRDX4
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Peroxiredoxin-4 (EC 1.11.1.15)(Prx-IV)(Thioredoxin peroxidase AO372)(Thioredoxin-dependent peroxide reductase A0372)(Antioxidant enzyme AOE372)(AOE37-2) [Source:UniProtKB/Swiss-Prot;Acc:Q13162]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PRDX4-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | AhpC-TSA | 81 | 214 |
PFAM A | 1-cysPrx_C | 224 | 267 |
Protein sequence [+]
PRDX4 | Homo sapiens | 9606 | length:271
MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY
PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF
TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL
THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK
HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF
TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL
THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK
HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0045454 | cell redox homeostasis | biological_proccess | IEA |
GO:0007252 | I-kappaB phosphorylation | biological_proccess | TAS |
GO:0055114 | oxidation reduction | biological_proccess | IEA |
GO:0016209 | antioxidant activity | mollecular_function | IEA |
GO:0016491 | oxidoreductase activity | mollecular_function | IEA |
GO:0008379 | thioredoxin peroxidase activity | mollecular_function | TAS |
GO:0005739 | mitochondrion | cell_component | IEA |
GO:0005737 | cytoplasm | cell_component | IEA |
GO:0005615 | extracellular space | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :17169
- Gene related info from GeneCards [?] : PRDX4
- Ensembl genome browser [?] : ENSG00000123131
- Expression info from Arrayexpress [?] : ENSG00000123131
- Protein expression from Protein Atlas: [?] ENSG00000123131
- Community gene edition from Wikigenes: [?] 10549
- OMIM gene information: 606506
- OMIM disease information:
Click on [?] for more information.