ZAP70 (Rattus norvegicus)
Description [+]
- Synonyms: ZAP70
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
- Short gene description: zeta-chain (TCR) associated protein kinase 70 [Source:RefSeq_peptide;Acc:NP_001012002]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: ZAP70-R_norvegicus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | SH2 | 10 | 87 |
PFAM A | SH2 | 163 | 239 |
PFAM A | Pkinase | 333 | 588 |
PFAM A | Pkinase_Tyr | 333 | 588 |
Protein sequence [+]
Zap70 | Rattus norvegicus | 10116 | length:614
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
QQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFTQPHRRIDTLNSDGYTPEPARLDKP
RPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQID
VAIKVLKQSTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKF
LIGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA
LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKG
PEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFVAVEQRMRTYYYSMASRAE
GPPQCEQVAEAACG
IERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
QQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFTQPHRRIDTLNSDGYTPEPARLDKP
RPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQID
VAIKVLKQSTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKF
LIGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA
LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKG
PEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFVAVEQRMRTYYYSMASRAE
GPPQCEQVAEAACG
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
GO:0007165 | signal transduction | biological_proccess | IEA |
GO:0006955 | immune response | biological_proccess | IEA |
GO:0045582 | positive regulation of T cell differentiation | biological_proccess | IEA |
GO:0045059 | positive thymic T cell selection | biological_proccess | IEA |
GO:0007242 | intracellular signaling cascade | biological_proccess | IEA |
GO:0046777 | protein amino acid autophosphorylation | biological_proccess | IEA |
GO:0050852 | T cell receptor signaling pathway | biological_proccess | IEA |
GO:0046641 | positive regulation of alpha-beta T cell proliferation | biological_proccess | IEA |
GO:0018108 | peptidyl-tyrosine phosphorylation | biological_proccess | IEA |
GO:0050850 | positive regulation of calcium-mediated signaling | biological_proccess | IEA |
GO:0046638 | positive regulation of alpha-beta T cell differentiation | biological_proccess | IEA |
GO:0045060 | negative thymic T cell selection | biological_proccess | IEA |
GO:0045061 | thymic T cell selection | biological_proccess | IEA |
GO:0043366 | beta selection | biological_proccess | IEA |
GO:0000166 | nucleotide binding | mollecular_function | IEA |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0016740 | transferase activity | mollecular_function | IEA |
GO:0004672 | protein kinase activity | mollecular_function | IEA |
GO:0004713 | protein tyrosine kinase activity | mollecular_function | IEA |
GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
GO:0001784 | phosphotyrosine binding | mollecular_function | IEA |
GO:0005737 | cytoplasm | cell_component | IEA |
GO:0042101 | T cell receptor complex | cell_component | IEA |
GO:0005829 | cytosol | cell_component | IEA |
Check GO Evidence Codes here
KEGG Pathways [+]
Information from other databases [+]
- Ensembl genome browser [?] : ENSRNOG00000016995
- Expression info from Arrayexpress [?] : ENSRNOG00000016995
- Protein expression from Protein Atlas: [?] ENSRNOG00000016995
- entrezgene: 301348
- refseq_dna: NM_001012002
- refseq_peptide: NP_001012002
Click on [?] for more information.