TNF (Rattus norvegicus)

Description [+]

Synonyms: TNF
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Rodentia; Rattus norvegicus
Short gene description: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]. [Source:UniProtKB/Swiss-Prot;Acc:P16599]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: TNF-R_norvegicus

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	TNF	105	235

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0001775	cell activation	biological_proccess	IDA
GO:0001932	regulation of protein amino acid phosphorylation	biological_proccess	IEA
GO:0002037	negative regulation of L-glutamate transport	biological_proccess	IDA
GO:0006006	glucose metabolic process	biological_proccess	IEA
GO:0006915	apoptosis	biological_proccess	IDA
GO:0006954	inflammatory response	biological_proccess	TAS
GO:0006959	humoral immune response	biological_proccess	IEA
GO:0007165	signal transduction	biological_proccess	IDA
GO:0007275	multicellular organismal development	biological_proccess	IEA
GO:0008285	negative regulation of cell proliferation	biological_proccess	IDA
GO:0008625	induction of apoptosis via death domain receptors	biological_proccess	IEA
GO:0009612	response to mechanical stimulus	biological_proccess	IEP
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0019722	calcium-mediated signaling	biological_proccess	IDA
GO:0042742	defense response to bacterium	biological_proccess	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_proccess	IEA
GO:0043525	positive regulation of neuron apoptosis	biological_proccess	IMP
GO:0045123	cellular extravasation	biological_proccess	IEA
GO:0045670	regulation of osteoclast differentiation	biological_proccess	IEA
GO:0045840	positive regulation of mitosis	biological_proccess	IMP
GO:0045941	positive regulation of transcription	biological_proccess	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0045994	positive regulation of translational initiation by iron	biological_proccess	IEA
GO:0046325	negative regulation of glucose import	biological_proccess	IEA
GO:0046330	positive regulation of JNK cascade	biological_proccess	IEA
GO:0050806	positive regulation of synaptic transmission	biological_proccess	IMP
GO:0051023	regulation of immunoglobulin secretion	biological_proccess	IEA
GO:0051222	positive regulation of protein transport	biological_proccess	IDA
GO:0051798	positive regulation of hair follicle development	biological_proccess	IEA
GO:0006955	immune response	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IEA
GO:0002740	negative regulation of cytokine secretion during immune response	biological_proccess	IEA
GO:0000187	activation of MAPK activity	biological_proccess	IEA
GO:0043193	positive regulation of gene-specific transcription	biological_proccess	IEA
GO:0001934	positive regulation of protein amino acid phosphorylation	biological_proccess	IEA
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological_proccess	IEA
GO:0045080	positive regulation of chemokine biosynthetic process	biological_proccess	IEA
GO:0016481	negative regulation of transcription	biological_proccess	IEA
GO:0050901	leukocyte tethering or rolling	biological_proccess	IEA
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	biological_proccess	IEA
GO:0006954	inflammatory response	biological_proccess	IEA
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological_proccess	IEA
GO:0006927	transformed cell apoptosis	biological_proccess	IEA
GO:0048661	positive regulation of smooth muscle cell proliferation	biological_proccess	IEA
GO:0032715	negative regulation of interleukin-6 production	biological_proccess	IEA
GO:0050995	negative regulation of lipid catabolic process	biological_proccess	IEA
GO:0051384	response to glucocorticoid stimulus	biological_proccess	IEA
GO:0030730	sequestering of triglyceride	biological_proccess	IEA
GO:0032722	positive regulation of chemokine production	biological_proccess	IEA
GO:0045071	negative regulation of viral genome replication	biological_proccess	IEA
GO:0009615	response to virus	biological_proccess	IEA
GO:0042346	positive regulation of NF-kappaB import into nucleus	biological_proccess	IEA
GO:0050715	positive regulation of cytokine secretion	biological_proccess	IEA
GO:0002439	chronic inflammatory response to antigenic stimulus	biological_proccess	IEA
GO:0006919	activation of caspase activity	biological_proccess	IEA
GO:0032800	receptor biosynthetic process	biological_proccess	IEA
GO:0050796	regulation of insulin secretion	biological_proccess	IEA
GO:0034116	positive regulation of heterotypic cell-cell adhesion	biological_proccess	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological_proccess	IEA
GO:0060559		biological_proccess	IEA
GO:0060557		biological_proccess	IEA
GO:0060555		biological_proccess	IEA
GO:0000060	protein import into nucleus, translocation	biological_proccess	IEA
GO:0006952	defense response	biological_proccess	IEA
GO:0007254	JNK cascade	biological_proccess	IEA
GO:0042127	regulation of cell proliferation	biological_proccess	IEA
GO:0006917	induction of apoptosis	biological_proccess	IEA
GO:0032755	positive regulation of interleukin-6 production	biological_proccess	IEA
GO:0008624	induction of apoptosis by extracellular signals	biological_proccess	IEA
GO:0050900	leukocyte migration	biological_proccess	IEA
GO:0030316	osteoclast differentiation	biological_proccess	IEA
GO:0005125	cytokine activity	mollecular_function	IEA
GO:0005164	tumor necrosis factor receptor binding	mollecular_function	IEA
GO:0042802	identical protein binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0001891	phagocytic cup	cell_component	IEA
GO:0005576	extracellular region	cell_component	IEA
GO:0005615	extracellular space	cell_component	IEA
GO:0005886	plasma membrane	cell_component	IEA
GO:0009897	external side of plasma membrane	cell_component	IEA
GO:0016021	integral to membrane	cell_component	IEA
GO:0045121	membrane raft	cell_component	IEA
GO:0055037	recycling endosome	cell_component	IEA
GO:0016020	membrane	cell_component	IEA
GO:0005887	integral to plasma membrane	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

KEGG report for Tnf: 24835

KEGG pathways for Tnf:

rno04010: MAPK signaling pathway (entry, map)

rno04060: Cytokine-cytokine receptor interaction (entry, map)

rno04210: Apoptosis (entry, map)

rno04350: TGF-beta signaling pathway (entry, map)

rno04620: Toll-like receptor signaling pathway (entry, map)

rno04640: Hematopoietic cell lineage (entry, map)

rno04650: Natural killer cell mediated cytotoxicity (entry, map)

rno04660: T cell receptor signaling pathway (entry, map)

rno04664: Fc epsilon RI signaling pathway (entry, map)

rno04920: Adipocytokine signaling pathway (entry, map)

rno04930: Type II diabetes mellitus (entry, map)

rno04940: Type I diabetes mellitus (entry, map)

rno05010: Alzheimer's disease (entry, map)

rno05060: Prion disease (entry, map)

rno05310: Asthma (entry, map)

rno05322: Systemic lupus erythematosus (entry, map)

rno05330: Allograft rejection (entry, map)

rno05332: Graft-versus-host disease (entry, map)

Information from other databases [+]

Gene related links:

Ensembl genome browser [?] : ENSRNOG00000000837
Expression info from Arrayexpress [?] : ENSRNOG00000000837
Protein expression from Protein Atlas: [?] ENSRNOG00000000837

Protein related links:

Uniprot protein info: P16599
PIR protein info: P16599
Protein interactions from IntAct: P16599

Other links

entrezgene: 24835
refseq_dna: NM_012675
refseq_peptide: NP_036807

Click on [?] for more information.