TP53 (Pongo pygmaeus)
Description [+]
- Synonyms: TP53
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Pongo pygmaeus
- Short gene description: Cellular tumor antigen p53 (Tumor suppressor p53)(Phosphoprotein p53)(Antigen NY-CO-13) [Source:UniProtKB/Swiss-Prot;Acc:P04637]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: TP53-P_pygmaeus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | P53_TAD | 5 | 29 |
PFAM A | P53 | 95 | 289 |
PFAM A | P53_tetramer | 318 | 359 |
Protein sequence [+]
TP53 | Pongo pygmaeus | 9600 | length:393
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAVDDLLLSPDDIAQWFIEDPGP
DEAPRMSEAASPVGPAPAAPIPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
DEAPRMSEAASPVGPAPAAPIPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Structure links:
- Prosite motif and domain information: PS00348
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-dependent | biological_proccess | IEA |
GO:0045449 | regulation of transcription | biological_proccess | IEA |
GO:0002347 | response to tumor cell | biological_proccess | IEA |
GO:0030308 | negative regulation of cell growth | biological_proccess | IEA |
GO:0006915 | apoptosis | biological_proccess | IEA |
GO:0001701 | in utero embryonic development | biological_proccess | IEA |
GO:0045893 | positive regulation of transcription, DNA-dependent | biological_proccess | IEA |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological_proccess | IEA |
GO:0045941 | positive regulation of transcription | biological_proccess | IEA |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological_proccess | IEA |
GO:0009303 | rRNA transcription | biological_proccess | IEA |
GO:0006974 | response to DNA damage stimulus | biological_proccess | IEA |
GO:0008285 | negative regulation of cell proliferation | biological_proccess | IEA |
GO:0042127 | regulation of cell proliferation | biological_proccess | IEA |
GO:0006917 | induction of apoptosis | biological_proccess | IEA |
GO:0051726 | regulation of cell cycle | biological_proccess | IEA |
GO:0006302 | double-strand break repair | biological_proccess | IEA |
GO:0051276 | chromosome organization | biological_proccess | IEA |
GO:0008156 | negative regulation of DNA replication | biological_proccess | IEA |
GO:0042493 | response to drug | biological_proccess | IEA |
GO:0048147 | negative regulation of fibroblast proliferation | biological_proccess | IEA |
GO:0043066 | negative regulation of apoptosis | biological_proccess | IEA |
GO:0007569 | cell aging | biological_proccess | IEA |
GO:0042771 | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | biological_proccess | IEA |
GO:0000060 | protein import into nucleus, translocation | biological_proccess | IEA |
GO:0043065 | positive regulation of apoptosis | biological_proccess | IEA |
GO:0043525 | positive regulation of neuron apoptosis | biological_proccess | IEA |
GO:0007417 | central nervous system development | biological_proccess | IEA |
GO:0010165 | response to X-ray | biological_proccess | IEA |
GO:0010332 | response to gamma radiation | biological_proccess | IEA |
GO:0033077 | T cell differentiation in the thymus | biological_proccess | IEA |
GO:0001836 | release of cytochrome c from mitochondria | biological_proccess | IEA |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | biological_proccess | IEA |
GO:0009411 | response to UV | biological_proccess | IEA |
GO:0007406 | negative regulation of neuroblast proliferation | biological_proccess | IEA |
GO:0007369 | gastrulation | biological_proccess | IEA |
GO:0043523 | regulation of neuron apoptosis | biological_proccess | IEA |
GO:0009792 | embryonic development ending in birth or egg hatching | biological_proccess | IEA |
GO:0002360 | T cell lineage commitment | biological_proccess | IEA |
GO:0002326 | B cell lineage commitment | biological_proccess | IEA |
GO:0046902 | regulation of mitochondrial membrane permeability | biological_proccess | IEA |
GO:0009651 | response to salt stress | biological_proccess | IEA |
GO:0031571 | G1 DNA damage checkpoint | biological_proccess | IEA |
GO:0002309 | T cell proliferation during immune response | biological_proccess | IEA |
GO:0034644 | cellular response to UV | biological_proccess | IEA |
GO:0008104 | protein localization | biological_proccess | IEA |
GO:0007275 | multicellular organismal development | biological_proccess | IEA |
GO:0010552 | positive regulation of specific transcription from RNA polymerase II promoter | biological_proccess | IEA |
GO:0006983 | ER overload response | biological_proccess | IEA |
GO:0006461 | protein complex assembly | biological_proccess | IEA |
GO:0008635 | activation of caspase activity by cytochrome c | biological_proccess | IEA |
GO:0006289 | nucleotide-excision repair | biological_proccess | IEA |
GO:0042149 | cellular response to glucose starvation | biological_proccess | IEA |
GO:0003677 | DNA binding | mollecular_function | IEA |
GO:0003700 | transcription factor activity | mollecular_function | IEA |
GO:0008270 | zinc ion binding | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0046982 | protein heterodimerization activity | mollecular_function | IEA |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0008134 | transcription factor binding | mollecular_function | IEA |
GO:0019899 | enzyme binding | mollecular_function | IEA |
GO:0010843 | promoter binding | mollecular_function | IEA |
GO:0047485 | protein N-terminus binding | mollecular_function | IEA |
GO:0051087 | chaperone binding | mollecular_function | IEA |
GO:0003682 | chromatin binding | mollecular_function | IEA |
GO:0005507 | copper ion binding | mollecular_function | IEA |
GO:0000739 | DNA strand annealing activity | mollecular_function | IEA |
GO:0005634 | nucleus | cell_component | IEA |
GO:0005737 | cytoplasm | cell_component | IEA |
GO:0005829 | cytosol | cell_component | IEA |
GO:0005657 | replication fork | cell_component | IEA |
GO:0016605 | PML body | cell_component | IEA |
GO:0005730 | nucleolus | cell_component | IEA |
GO:0016363 | nuclear matrix | cell_component | IEA |
GO:0005739 | mitochondrion | cell_component | IEA |
GO:0005669 | transcription factor TFIID complex | cell_component | IEA |
GO:0005654 | nucleoplasm | cell_component | IEA |
GO:0005626 | insoluble fraction | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSPPYG00000007934
- Expression info from Arrayexpress [?] : ENSPPYG00000007934
- Protein expression from Protein Atlas: [?] ENSPPYG00000007934
Click on [?] for more information.