TLR4 (Ornithorhynchus anatinus)
Description [+]
- Synonyms: TLR4
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Prototheria; Ornithorhynchus anatinus
- Short gene description: Toll-like receptor 4 Precursor (hToll)(CD284 antigen) [Source:UniProtKB/Swiss-Prot;Acc:O00206]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: TLR4-O_anatinus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | TIR | 651 | 789 |
Protein sequence [+]
TLR4 | Ornithorhynchus anatinus | 9258 | length:813
LQVVANITYQCMELDLSEVPAEIPSSAQNLDLSFNPLGTLVPKGFSMLPDLRMLDLTRCQ
IQVIEDDAFRGLCNLSTLILTGNPVQRLGASAFSGLKMLQKLVAVEMQVVSLEDLPLGHL
TALRELNLGHNFIRSSKLPSYFAHLVSLQYLNLYKNKISMILLEDLNVLKQRQQPLLTLV
LSLNNILNIELGSFEGLHLQALEMRGCFNDVNVTKTCINALAGLQVHQLVLGDFRENHND
MPEDFGVFDGLCKVDIEEFRIVYYKGLIYNTNIFSNCLLNVSVLRVVSTSLNEVANLPAA
TRWQTLHFNRCGFSEVPAKSLRPLTQLKELQITENDELKEFEQDFCLPNLESLDLSRNRL
NFKSCCSETLFGTPRLKHLNLSFNFHIDITVNFMGLVELQYLDLQHSKLNGPGHFSAFVL
LTKLIYLDISYTNTHIDSAGTFYGLESLQVLKMAGNTFHNRFLKDNFRNVTRLLYLDISN
CQLEQVSHQAFTSLHQLQELNISHNKLLTFPVACAPLQSLKVLDCSFNLIAAPEEEALRS
LSQTLVRLDLSQNPLDCFCDHLGFLQWVKDHRKQLWKPERMTCARPSDLANTLVLDFKPS
VCEVKRILMWVSVVGVLAIAFIVVLVYKFYFHLMLLSGCKRYGPGGNTYDAFVIYSSQDE
EWVRNELVKNLEEGVPPFQLCLHYRDFMPGVAITSNIIQEGFHKSRKVIVVVSKHFMESR
WCSFEFEIAQTWQFLESQAGIILIVLQKVDKSQLQRRMGLSRYLHRNTYLEWEDNKISRH
IFWRRLRNALLDGSVPSGIREKVGGINESITGI
IQVIEDDAFRGLCNLSTLILTGNPVQRLGASAFSGLKMLQKLVAVEMQVVSLEDLPLGHL
TALRELNLGHNFIRSSKLPSYFAHLVSLQYLNLYKNKISMILLEDLNVLKQRQQPLLTLV
LSLNNILNIELGSFEGLHLQALEMRGCFNDVNVTKTCINALAGLQVHQLVLGDFRENHND
MPEDFGVFDGLCKVDIEEFRIVYYKGLIYNTNIFSNCLLNVSVLRVVSTSLNEVANLPAA
TRWQTLHFNRCGFSEVPAKSLRPLTQLKELQITENDELKEFEQDFCLPNLESLDLSRNRL
NFKSCCSETLFGTPRLKHLNLSFNFHIDITVNFMGLVELQYLDLQHSKLNGPGHFSAFVL
LTKLIYLDISYTNTHIDSAGTFYGLESLQVLKMAGNTFHNRFLKDNFRNVTRLLYLDISN
CQLEQVSHQAFTSLHQLQELNISHNKLLTFPVACAPLQSLKVLDCSFNLIAAPEEEALRS
LSQTLVRLDLSQNPLDCFCDHLGFLQWVKDHRKQLWKPERMTCARPSDLANTLVLDFKPS
VCEVKRILMWVSVVGVLAIAFIVVLVYKFYFHLMLLSGCKRYGPGGNTYDAFVIYSSQDE
EWVRNELVKNLEEGVPPFQLCLHYRDFMPGVAITSNIIQEGFHKSRKVIVVVSKHFMESR
WCSFEFEIAQTWQFLESQAGIILIVLQKVDKSQLQRRMGLSRYLHRNTYLEWEDNKISRH
IFWRRLRNALLDGSVPSGIREKVGGINESITGI
Structure links:
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0045084 | positive regulation of interleukin-12 biosynthetic process | biological_proccess | IEA |
GO:0042116 | macrophage activation | biological_proccess | IEA |
GO:0032497 | detection of lipopolysaccharide | biological_proccess | IEA |
GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | biological_proccess | IEA |
GO:0045416 | positive regulation of interleukin-8 biosynthetic process | biological_proccess | IEA |
GO:0032760 | positive regulation of tumor necrosis factor production | biological_proccess | IEA |
GO:0032496 | response to lipopolysaccharide | biological_proccess | IEA |
GO:0032755 | positive regulation of interleukin-6 production | biological_proccess | IEA |
GO:0032874 | positive regulation of stress-activated MAPK cascade | biological_proccess | IEA |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | biological_proccess | IEA |
GO:0046330 | positive regulation of JNK cascade | biological_proccess | IEA |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | biological_proccess | IEA |
GO:0032609 | interferon-gamma production | biological_proccess | IEA |
GO:0009617 | response to bacterium | biological_proccess | IEA |
GO:0010572 | positive regulation of platelet activation | biological_proccess | IEA |
GO:0002537 | production of nitric oxide during acute inflammatory response | biological_proccess | IEA |
GO:0070430 | positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway | biological_proccess | IEA |
GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway | biological_proccess | IEA |
GO:0004888 | transmembrane receptor activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0001875 | lipopolysaccharide receptor activity | mollecular_function | IEA |
GO:0016020 | membrane | cell_component | IEA |
GO:0005887 | integral to plasma membrane | cell_component | IEA |
GO:0009897 | external side of plasma membrane | cell_component | IEA |
GO:0048471 | perinuclear region of cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSOANG00000013202
- Expression info from Arrayexpress [?] : ENSOANG00000013202
- Protein expression from Protein Atlas: [?] ENSOANG00000013202
- entrezgene: 100077705
Click on [?] for more information.