IGF1R (Ornithorhynchus anatinus)
Description [+]
- Synonyms: IGF1R
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Prototheria; Ornithorhynchus anatinus
- Short gene description: Insulin-like growth factor 1 receptor Precursor (EC 2.7.10.1)(Insulin-like growth factor I receptor)(IGF-I receptor)(CD221 antigen) [Contains Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain] [Source:UniProtKB/Swiss-Prot;Acc:P08069]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: IGF1R-O_anatinus
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Furin-like | 1 | 120 |
PFAM A | Recep_L_domain | 139 | 254 |
PFAM A | Pkinase | 799 | 1066 |
PFAM A | Pkinase_Tyr | 799 | 1066 |
Protein sequence [+]
IGF1R | Ornithorhynchus anatinus | 9258 | length:1162
VCPSVCGKRACTDQNECCHPECLGSCSAPDNSTACVACRHYYYEGTCVPTCPPNTYKFEG
WRCVNRDFCSKVPGPDINEFEKFVIHNDECMQECPSGFIRNGSQSMFCSPCEGPCPKICE
EEKKTKTIDSVTSAQMLQGCTVFKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS
HALVSLSFLKSLRYILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTIKEGKMYFAFNPK
LCVSEIYRMEEVSGTKGRQTKGDINTRNNGERASCESDILHFISNTTMKNRIKLTWQRYR
PPDYRDLISFTVYYKEAQMKNKHEVRKGKCMKHGWEKVAQDKPIDARTVKSEKPNNLARY
MMSLKQWAVFPMLSSYVVKHLMFSGLGHTYLTSSSLVIVQSPLSPSNSFSISFTGSSSVP
DAFPFSHPNANFFLFAIYFVLVYFNALTLLPIVLWQSMFPHSSRTSSIARREEIYPGAII
LCFCPVTPTAYIKQMNSRSCLFKQTKQYNQSLIRLFRGTASGSSILQPSLPKLSLTEKGS
KTPKNNTTPDSWNLSLGVRTGKSQEHQSARPSRLLRVTLQSLGYSQQESEGTRIVALLNK
TIRDSPLFHLPTLAYCLPQFRLAGKGADNIPGPVTWEGRKEDNTIYLKWMEPENPNGLIL
MYEIKYGQHMEDQRECISRQEYRKYGGARLTRLAPGNYSARVQATSLSGNGSWTEPVSFY
VQAKGDVRMNVLLIVGGLLIMLYVFNKKRNAFFPFYRNSDRLGNGVLYASVNPEYFSAAD
DFPSSLYVPDEWEVPREKITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESAS
MRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTEN
NPGQAPPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI
YETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQ
VLRFVMEGGLLEKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDELDPAFKEVSFF
YSEENKPPDTEELDLETENMESIPLDPSSTLQPSEKHSGHKAENGPGVVVLRASFDERQP
YAHMNGGRKNERALPLPQSSAC
WRCVNRDFCSKVPGPDINEFEKFVIHNDECMQECPSGFIRNGSQSMFCSPCEGPCPKICE
EEKKTKTIDSVTSAQMLQGCTVFKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS
HALVSLSFLKSLRYILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTIKEGKMYFAFNPK
LCVSEIYRMEEVSGTKGRQTKGDINTRNNGERASCESDILHFISNTTMKNRIKLTWQRYR
PPDYRDLISFTVYYKEAQMKNKHEVRKGKCMKHGWEKVAQDKPIDARTVKSEKPNNLARY
MMSLKQWAVFPMLSSYVVKHLMFSGLGHTYLTSSSLVIVQSPLSPSNSFSISFTGSSSVP
DAFPFSHPNANFFLFAIYFVLVYFNALTLLPIVLWQSMFPHSSRTSSIARREEIYPGAII
LCFCPVTPTAYIKQMNSRSCLFKQTKQYNQSLIRLFRGTASGSSILQPSLPKLSLTEKGS
KTPKNNTTPDSWNLSLGVRTGKSQEHQSARPSRLLRVTLQSLGYSQQESEGTRIVALLNK
TIRDSPLFHLPTLAYCLPQFRLAGKGADNIPGPVTWEGRKEDNTIYLKWMEPENPNGLIL
MYEIKYGQHMEDQRECISRQEYRKYGGARLTRLAPGNYSARVQATSLSGNGSWTEPVSFY
VQAKGDVRMNVLLIVGGLLIMLYVFNKKRNAFFPFYRNSDRLGNGVLYASVNPEYFSAAD
DFPSSLYVPDEWEVPREKITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESAS
MRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTEN
NPGQAPPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI
YETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQ
VLRFVMEGGLLEKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDELDPAFKEVSFF
YSEENKPPDTEELDLETENMESIPLDPSSTLQPSEKHSGHKAENGPGVVVLRASFDERQP
YAHMNGGRKNERALPLPQSSAC
Structure links:
- Smartdomain prediction information: SM00179
- Smartdomain prediction information: SM00261
- Smartdomain prediction information: SM00060
- Smartdomain prediction information: SM00219
- Smartdomain prediction information: SM00220
- Prosite motif and domain information: PS00107
- Prosite motif and domain information: PS00109
- Prosite motif and domain information: PS00239
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological_proccess | IEA |
GO:0007420 | brain development | biological_proccess | IEA |
GO:0030879 | mammary gland development | biological_proccess | IEA |
GO:0009887 | organ morphogenesis | biological_proccess | IEA |
GO:0030238 | male sex determination | biological_proccess | IEA |
GO:0046777 | protein amino acid autophosphorylation | biological_proccess | IEA |
GO:0045740 | positive regulation of DNA replication | biological_proccess | IEA |
GO:0030335 | positive regulation of cell migration | biological_proccess | IEA |
GO:0006955 | immune response | biological_proccess | IEA |
GO:0048015 | phosphoinositide-mediated signaling | biological_proccess | IEA |
GO:0048009 | insulin-like growth factor receptor signaling pathway | biological_proccess | IEA |
GO:0051262 | protein tetramerization | biological_proccess | IEA |
GO:0004672 | protein kinase activity | mollecular_function | IEA |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0004713 | protein tyrosine kinase activity | mollecular_function | IEA |
GO:0005509 | calcium ion binding | mollecular_function | IEA |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | mollecular_function | IEA |
GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IEA |
GO:0005158 | insulin receptor binding | mollecular_function | IEA |
GO:0042802 | identical protein binding | mollecular_function | IEA |
GO:0031994 | insulin-like growth factor I binding | mollecular_function | IEA |
GO:0043559 | insulin binding | mollecular_function | IEA |
GO:0043560 | insulin receptor substrate binding | mollecular_function | IEA |
GO:0043548 | phosphoinositide 3-kinase binding | mollecular_function | IEA |
GO:0005010 | insulin-like growth factor receptor activity | mollecular_function | IEA |
GO:0016020 | membrane | cell_component | IEA |
GO:0005792 | microsome | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Ensembl genome browser [?] : ENSOANG00000000134
- Expression info from Arrayexpress [?] : ENSOANG00000000134
- Protein expression from Protein Atlas: [?] ENSOANG00000000134
Click on [?] for more information.