TNFA_MACMU (Macaca mulatta)

Description [+]

Synonyms: TNFA_MACMU
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Cercopithecidae; Macaca mulatta
Short gene description: Tumor necrosis factor precursor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form]. [Source:UniProtKB/Swiss-Prot;Acc:P48094]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: TNFA_MACMU-M_mulatta

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	TNF	102	233

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006955	immune response	biological_proccess	IEA
GO:0000060	protein import into nucleus, translocation	biological_proccess	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0000187	activation of MAPK activity	biological_proccess	IEA
GO:0001932	regulation of protein amino acid phosphorylation	biological_proccess	IEA
GO:0001934	positive regulation of protein amino acid phosphorylation	biological_proccess	IEA
GO:0002439	chronic inflammatory response to antigenic stimulus	biological_proccess	IEA
GO:0002740	negative regulation of cytokine secretion during immune response	biological_proccess	IEA
GO:0006006	glucose metabolic process	biological_proccess	IEA
GO:0006916	anti-apoptosis	biological_proccess	IEA
GO:0006917	induction of apoptosis	biological_proccess	IEA
GO:0006919	activation of caspase activity	biological_proccess	IEA
GO:0006927	transformed cell apoptosis	biological_proccess	IEA
GO:0006952	defense response	biological_proccess	IEA
GO:0006954	inflammatory response	biological_proccess	IEA
GO:0006959	humoral immune response	biological_proccess	IEA
GO:0007254	JNK cascade	biological_proccess	IEA
GO:0007275	multicellular organismal development	biological_proccess	IEA
GO:0008624	induction of apoptosis by extracellular signals	biological_proccess	IEA
GO:0008625	induction of apoptosis via death domain receptors	biological_proccess	IEA
GO:0009615	response to virus	biological_proccess	IEA
GO:0009887	organ morphogenesis	biological_proccess	IEA
GO:0016481	negative regulation of transcription	biological_proccess	IEA
GO:0030316	osteoclast differentiation	biological_proccess	IEA
GO:0032715	negative regulation of interleukin-6 production	biological_proccess	IEA
GO:0032722	positive regulation of chemokine production	biological_proccess	IEA
GO:0032800	receptor biosynthetic process	biological_proccess	IEA
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological_proccess	IEA
GO:0034116	positive regulation of heterotypic cell-cell adhesion	biological_proccess	IEA
GO:0042127	regulation of cell proliferation	biological_proccess	IEA
GO:0042346	positive regulation of NF-kappaB import into nucleus	biological_proccess	IEA
GO:0042742	defense response to bacterium	biological_proccess	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_proccess	IEA
GO:0043193	positive regulation of gene-specific transcription	biological_proccess	IEA
GO:0045071	negative regulation of viral genome replication	biological_proccess	IEA
GO:0045080	positive regulation of chemokine biosynthetic process	biological_proccess	IEA
GO:0045123	cellular extravasation	biological_proccess	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological_proccess	IEA
GO:0045670	regulation of osteoclast differentiation	biological_proccess	IEA
GO:0045941	positive regulation of transcription	biological_proccess	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological_proccess	IEA
GO:0045994	positive regulation of translational initiation by iron	biological_proccess	IEA
GO:0046325	negative regulation of glucose import	biological_proccess	IEA
GO:0046330	positive regulation of JNK cascade	biological_proccess	IEA
GO:0048661	positive regulation of smooth muscle cell proliferation	biological_proccess	IEA
GO:0050715	positive regulation of cytokine secretion	biological_proccess	IEA
GO:0050796	regulation of insulin secretion	biological_proccess	IEA
GO:0050900	leukocyte migration	biological_proccess	IEA
GO:0050901	leukocyte tethering or rolling	biological_proccess	IEA
GO:0051023	regulation of immunoglobulin secretion	biological_proccess	IEA
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological_proccess	IEA
GO:0051384	response to glucocorticoid stimulus	biological_proccess	IEA
GO:0051798	positive regulation of hair follicle development	biological_proccess	IEA
GO:0032755	positive regulation of interleukin-6 production	biological_proccess	IEA
GO:0051044	positive regulation of membrane protein ectodomain proteolysis	biological_proccess	IEA
GO:0050995	negative regulation of lipid catabolic process	biological_proccess	IEA
GO:0030730	sequestering of triglyceride	biological_proccess	IEA
GO:0060559		biological_proccess	IEA
GO:0060557		biological_proccess	IEA
GO:0060555		biological_proccess	IEA
GO:0005125	cytokine activity	mollecular_function	IEA
GO:0005164	tumor necrosis factor receptor binding	mollecular_function	IEA
GO:0042802	identical protein binding	mollecular_function	IEA
GO:0005515	protein binding	mollecular_function	IEA
GO:0005615	extracellular space	cell_component	IEA
GO:0016020	membrane	cell_component	IEA
GO:0001891	phagocytic cup	cell_component	IEA
GO:0005576	extracellular region	cell_component	IEA
GO:0005886	plasma membrane	cell_component	IEA
GO:0009897	external side of plasma membrane	cell_component	IEA
GO:0016021	integral to membrane	cell_component	IEA
GO:0055037	recycling endosome	cell_component	IEA
GO:0045121	membrane raft	cell_component	IEA
GO:0005887	integral to plasma membrane	cell_component	IEA

Check GO Evidence Codes here

Information from other databases [+]