AIFM3 (Homo sapiens)
Description [+]
- Synonyms: AIFM3
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Apoptosis-inducing factor 3 (EC 1.-.-.-)(Apoptosis-inducing factor-like protein) [Source:UniProtKB/Swiss-Prot;Acc:Q96NN9]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: AIFM3-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Rieske | 68 | 161 |
PFAM A | Pyr_redox | 196 | 298 |
PFAM A | Pyr_redox_2 | 196 | 473 |
PFAM A | Pyr_redox | 334 | 428 |
Protein sequence [+]
AIFM3 | Homo sapiens | 9606 | length:605
MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRAYQGNGTARHFHTEERLSTPHP
YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV
LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV
MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK
SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS
PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV
VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA
DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK
VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL
EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL
TGKGS
YPSPQDCVEAAVCHVKDLENGQMREVELGWGKVLLVKDNGEFHALGHKCPHYGAPLVKGV
LSRGRVRCPWHGACFNISTGDLEDFPGLDSLHKFQVKIEKEKVYVRASKQALQLQRRTKV
MAKCISPSAGYSSSTNVLIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSK
SLDTQPEQLALRPKEFFRAYGIEVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSS
PKTLSCKGKEVENVFTIRTPEDANRVVRLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSV
VELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGKLKEVVLKSSKVVRA
DVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTNVPGVFAAGDAVTFPLAWRNNRK
VNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSLRYAGYGEGFDDVIIQGDL
EELKFVAFYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKREVELFVLHSKTGDMSWL
TGKGS
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0055114 | oxidation reduction | biological_proccess | IEA |
GO:0006917 | induction of apoptosis | biological_proccess | IDA |
GO:0008635 | activation of caspase activity by cytochrome c | biological_proccess | IDA |
GO:0051882 | mitochondrial depolarization | biological_proccess | IDA |
GO:0045454 | cell redox homeostasis | biological_proccess | IEA |
GO:0006810 | transport | biological_proccess | IEA |
GO:0006915 | apoptosis | biological_proccess | IEA |
GO:0022900 | electron transport chain | biological_proccess | IEA |
GO:0016491 | oxidoreductase activity | mollecular_function | IEA |
GO:0009055 | electron carrier activity | mollecular_function | IEA |
GO:0051537 | 2 iron, 2 sulfur cluster binding | mollecular_function | IEA |
GO:0008656 | caspase activator activity | mollecular_function | IDA |
GO:0050660 | FAD binding | mollecular_function | IEA |
GO:0005506 | iron ion binding | mollecular_function | IEA |
GO:0046872 | metal ion binding | mollecular_function | IEA |
GO:0005739 | mitochondrion | cell_component | IDA |
GO:0005743 | mitochondrial inner membrane | cell_component | IDA |
GO:0005783 | endoplasmic reticulum | cell_component | IDA |
GO:0005737 | cytoplasm | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :26398
- Gene related info from GeneCards [?] : AIFM3
- Ensembl genome browser [?] : ENSG00000183773
- Expression info from Arrayexpress [?] : ENSG00000183773
- Protein expression from Protein Atlas: [?] ENSG00000183773
- Community gene edition from Wikigenes: [?] 150209
- entrezgene: 150209
- refseq_dna: NM_144704
- refseq_dna: NM_001018060
- refseq_peptide: NP_653305
- refseq_peptide: NP_001018070
Click on [?] for more information.