CD40 (Homo sapiens)

Description [+]

Synonyms: CD40
Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
Short gene description: Tumor necrosis factor receptor superfamily member 5 Precursor (CD40L receptor)(B-cell surface antigen CD40)(Bp50)(CDw40)(CD40 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P25942]
Family: Null
Process:
Pathways:
Criteria: homology search
Curator comment: Null
WIKI: CD40-H_sapiens

Structure & Sequence [+]

Source	Domain Name	Start	End
PFAM A	TNFR_c6	26	59

Evolution [+]

Gene Ontology [+]

GO id	Name	Ontology type	Evidence
GO:0006915	apoptosis	biological_proccess	IEA
GO:0006955	immune response	biological_proccess	IEA
GO:0007165	signal transduction	biological_proccess	IEA
GO:0006461	protein complex assembly	biological_proccess	TAS
GO:0006954	inflammatory response	biological_proccess	TAS
GO:0042100	B cell proliferation	biological_proccess	NAS
GO:0030168	platelet activation	biological_proccess	NAS
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological_proccess	IEP
GO:0030890	positive regulation of B cell proliferation	biological_proccess	IEA
GO:0032735	positive regulation of interleukin-12 production	biological_proccess	IEA
GO:0050776	regulation of immune response	biological_proccess	IEA
GO:0048304	positive regulation of isotype switching to IgG isotypes	biological_proccess	IEA
GO:0042113	B cell activation	biological_proccess	IEA
GO:0051023	regulation of immunoglobulin secretion	biological_proccess	IEA
GO:0002768	immune response-regulating cell surface receptor signaling pathway	biological_proccess	IEA
GO:0006954	inflammatory response	biological_proccess	IEA
GO:0004872	receptor activity	mollecular_function	IEA
GO:0004888	transmembrane receptor activity	mollecular_function	IEA
GO:0004872	receptor activity	mollecular_function	TAS
GO:0019899	enzyme binding	mollecular_function	IPI
GO:0005515	protein binding	mollecular_function	IEA
GO:0016020	membrane	cell_component	IEA
GO:0005886	plasma membrane	cell_component	TAS
GO:0005887	integral to plasma membrane	cell_component	TAS
GO:0005576	extracellular region	cell_component	IEA
GO:0009897	external side of plasma membrane	cell_component	IEA
GO:0043231	intracellular membrane-bounded organelle	cell_component	IEA

Check GO Evidence Codes here

KEGG Pathways [+]

Information from other databases [+]

Gene related links:

Gene info from HGNC [?] :11919
Gene related info from GeneCards [?] : CD40
Ensembl genome browser [?] : ENSG00000101017
Expression info from Arrayexpress [?] : ENSG00000101017
Protein expression from Protein Atlas: [?] ENSG00000101017
Community gene edition from Wikigenes: [?] 958

Protein related links:

Uniprot protein info: P25942
PIR protein info: P25942
Protein interactions from IntAct: P25942

Gene and disease information from OMIM: (For a full disease description table, click here.)

OMIM gene information: 109535
OMIM disease information: 606843

Other links

entrezgene: 958
refseq_dna: NM_001250
refseq_dna: NM_152854
refseq_peptide: NP_001241
refseq_peptide: NP_690593

Click on [?] for more information.