PRDX2 (Homo sapiens)
Description [+]
- Synonyms: PRDX2
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Peroxiredoxin-2 (EC 1.11.1.15)(Thioredoxin peroxidase 1)(Thioredoxin-dependent peroxide reductase 1)(Thiol-specific antioxidant protein)(TSA)(PRP)(Natural killer cell-enhancing factor B)(NKEF-B) [Source:UniProtKB/Swiss-Prot;Acc:P32119]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: PRDX2-H_sapiens
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Redoxin | 7 | 162 |
PFAM A | AhpC-TSA | 8 | 141 |
PFAM A | 1-cysPrx_C | 151 | 194 |
Protein sequence [+]
PRDX2 | Homo sapiens | 9606 | length:198
MASGNARIGKPAPDFKATAVVDGAFKEVKLSDYKGKYVVLFFYPLDFTFVCPTEIIAFSN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN
RAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTRRLSEDYGVLKT
DEGIAYRGLFIIDGKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGS
DTIKPNVDDSKEYFSKHN
Evolution [+]
Explore tree at phylomeDB:   Click here.
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0055114 | oxidation reduction | biological_proccess | IEA |
GO:0006979 | response to oxidative stress | biological_proccess | NAS |
GO:0006916 | anti-apoptosis | biological_proccess | TAS |
GO:0042981 | regulation of apoptosis | biological_proccess | IMP |
GO:0045454 | cell redox homeostasis | biological_proccess | IEA |
GO:0032088 | negative regulation of NF-kappaB transcription factor activity | biological_proccess | IEA |
GO:0032496 | response to lipopolysaccharide | biological_proccess | IEA |
GO:0006916 | anti-apoptosis | biological_proccess | IEA |
GO:0000187 | activation of MAPK activity | biological_proccess | IEA |
GO:0048538 | thymus development | biological_proccess | IEA |
GO:0048872 | homeostasis of number of cells | biological_proccess | IEA |
GO:0042743 | hydrogen peroxide metabolic process | biological_proccess | IEA |
GO:0042098 | T cell proliferation | biological_proccess | IEA |
GO:0045581 | negative regulation of T cell differentiation | biological_proccess | IEA |
GO:0042744 | hydrogen peroxide catabolic process | biological_proccess | IEA |
GO:0002536 | respiratory burst during acute inflammatory response | biological_proccess | IEA |
GO:0010310 | regulation of hydrogen peroxide metabolic process | biological_proccess | IEA |
GO:0010671 | negative regulation of oxygen and reactive oxygen species metabolic process | biological_proccess | IEA |
GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway | biological_proccess | IEA |
GO:0016209 | antioxidant activity | mollecular_function | IEA |
GO:0016491 | oxidoreductase activity | mollecular_function | IEA |
GO:0008379 | thioredoxin peroxidase activity | mollecular_function | IDA |
GO:0005737 | cytoplasm | cell_component | TAS |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from HGNC [?] :9353
- Gene related info from GeneCards [?] : PRDX2
- Ensembl genome browser [?] : ENSG00000167815
- Expression info from Arrayexpress [?] : ENSG00000167815
- Protein expression from Protein Atlas: [?] ENSG00000167815
- Community gene edition from Wikigenes: [?] 7001
- OMIM gene information: 600538
- OMIM disease information:
Click on [?] for more information.