CSE1L (Homo sapiens)
Description [+]
- Synonyms: CSE1L, CAS, XPO2, CSE1
- Species: Metazoa;Bilateria;Deuterostoma;Chordata;Vertebrata;Mammalia;Primates;Hominidae; Homo sapiens
- Short gene description: Exportin-2 (Exp2)(Importin-alpha re-exporter)(Chromosome segregation 1-like protein)(Cellular apoptosis susceptibility protein) [Source:UniProtKB/Swiss-Prot;Acc:P55060]
- Family: other
- Process: apoptosis,
- Pathways: extrinsic pathway, post-mitochondrial caspase activation,
- Criteria: manually curated
- Curator comment:
- Mouse ortholog(s): Cse1l
- WIKI: CSE1L-H_sapiens
References [+]
- PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.
- Kim HE, Jiang X, Du F, Wang X
- During apoptosis, cytochrome c is released from mitochondria to the cytosol, where it binds Apaf-1. The Apaf-1/cytochrome c complex then oligomerizes either into heptameric caspase-9-activating apoptosome, which subsequently activates caspase-3 and caspase-7, or bigger inactive aggregates, depending on the availability of nucleotide dATP/ATP. A tumor suppressor protein, PHAPI, enhances caspase-9 activation by promoting apoptosome formation through an unknown mechanism. We report here the identification of cellular apoptosis susceptibility protein (CAS) and heat shock protein 70 (Hsp70) as mediators of PHAPI activity. PHAPI, CAS, and Hsp70 function together to accelerate nucleotide exchange on Apaf-1 and prevent inactive Apaf-1/cytochrome c aggregation. CAS expression is induced by multiple apoptotic stimuli including UV irradiation. Knockdown of CAS by RNA interference (RNAi) in cells attenuates apoptosis induced by UV light and causes endogenous Apaf-1 to form aggregates. These studies indicated that PHAPI, CAS, and Hsp70 play an important regulatory role during apoptosis. Mol Cell. 2008 Apr 25;30(2):239-47.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | IBN_N | 29 | 102 |
| PFAM A | Cse1 | 156 | 526 |
| PFAM A | CAS_CSE1 | 527 | 962 |
Protein sequence [+]
CSE1L | Homo sapiens | 9606 | length:971
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKV
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| A_aegypti_AAEL008741-PA | orthology | Aedes |
| A_gambiae_AGAP010711-PA | orthology | Anopheles |
| CSE1L | orthology | Chicken |
| CSE1L | orthology | Chimpanzee |
| C_intestinalis_ENSCINP00000004657 | orthology | Ciona |
| XPO2_BOVIN | orthology | Cow |
| CSE1L | orthology | Dog |
| Cas | orthology | Fly |
| CSE1L | orthology | Fugu |
| CSE1L | orthology | Gasterosteus |
| CSE1L | orthology | Gorilla |
| CSE1L | orthology | Horse |
| CSE1L | orthology | Lyzard |
| CSE1L | orthology | Macaca |
| CSE1L | orthology | Medaka |
| CSE1L | orthology | Monodelphis |
| Cse1l | orthology | Mouse |
| XPO2_PONPY | orthology | Orangutan |
| CSE1L | orthology | Ornithorhynchus |
| CSE1L | orthology | Rabbit |
| NP_001102077.1 | orthology | Rat |
| CSE1L | orthology | Tetraodon |
| xpo-2 | orthology | Worm |
| CSE1L | orthology | Xenopus |
| CSE1 | orthology | Yeast |
| CSE1L | orthology | Zebra finch |
| cse1l | orthology | Zebrafish |
| A_aegypti_AAEL004441-PA | paralogy | Aedes |
| XR_026868.1 | paralogy | Chicken |
| IPO8 | paralogy | Chicken |
| IPO7 | paralogy | Chimpanzee |
| IPO8 | paralogy | Chimpanzee |
| C_intestinalis_ENSCINP00000017536 | paralogy | Ciona |
| IPI00714160.3 | paralogy | Cow |
| IPI00701574.2 | paralogy | Cow |
| IPO7 | paralogy | Dog |
| IPO8 | paralogy | Dog |
| msk | paralogy | Fly |
| IPO8 | paralogy | Fugu |
| IPO7 | paralogy | Fugu |
| IPO8 | paralogy | Gasterosteus |
| IPO7 | paralogy | Gasterosteus |
| IPO7 | paralogy | Horse |
| IPO8 | paralogy | Horse |
| IPO7 | paralogy | Human |
| IPO8 | paralogy | Human |
| IPO7 | paralogy | Lyzard |
| IPO8 | paralogy | Lyzard |
| IPO8 | paralogy | Macaca |
| IPO8 | paralogy | Medaka |
| IPO7 | paralogy | Medaka |
| IPO7 | paralogy | Monodelphis |
| Ipo8 | paralogy | Mouse |
| Ipo7 | paralogy | Mouse |
| IPO8 | paralogy | Orangutan |
| IPO7 | paralogy | Ornithorhynchus |
| IPO7 | paralogy | Rabbit |
| NP_001101015.1 | paralogy | Rat |
| IPO7 | paralogy | Tetraodon |
| IPO8 | paralogy | Tetraodon |
| IPO7 | paralogy | Xenopus |
| NMD5 | paralogy | Yeast |
| IPO8 | paralogy | Zebra finch |
| IPO7 | paralogy | Zebra finch |
| zgc:76878 | paralogy | Zebrafish |
| si:ch211-116i17.1 | paralogy | Zebrafish |
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Gene Ontology [+]
| GO id | Name | Ontology type | Evidence |
|---|---|---|---|
| GO:0000059 | protein import into nucleus, docking | biological_proccess | IEA |
| GO:0006886 | intracellular protein transport | biological_proccess | IEA |
| GO:0008283 | cell proliferation | biological_proccess | IEA |
| GO:0006915 | apoptosis | biological_proccess | TAS |
| GO:0008283 | cell proliferation | biological_proccess | TAS |
| GO:0005488 | binding | mollecular_function | IEA |
| GO:0008565 | protein transporter activity | mollecular_function | IEA |
| GO:0008262 | importin-alpha export receptor activity | mollecular_function | IEA |
| GO:0005515 | protein binding | mollecular_function | IPI |
| GO:0008262 | importin-alpha export receptor activity | mollecular_function | TAS |
| GO:0005634 | nucleus | cell_component | IEA |
| GO:0005643 | nuclear pore | cell_component | IEA |
| GO:0005737 | cytoplasm | cell_component | IEA |
| GO:0005634 | nucleus | cell_component | TAS |
| GO:0005737 | cytoplasm | cell_component | TAS |
Check GO Evidence Codes here
Curated Isoforms [+]
| Transcript | Translation |
|---|---|
| OTTHUMT00000080344 | |
| OTTHUMT00000080345 * | OTTHUMP00000043373 * |
| OTTHUMT00000106496 |
Info from The Vertebrate Genome Annotation (VEGA) database.
(*) Canonical transcript and translation forms.
Information from other databases [+]
- Gene info from HGNC [?] :2431
- Gene related info from GeneCards [?] : CSE1L
- Ensembl genome browser [?] : ENSG00000124207
- Expression info from Arrayexpress [?] : ENSG00000124207
- Protein expression from Protein Atlas: [?] ENSG00000124207
- Community gene edition from Wikigenes: [?] 1434
- OMIM gene information: 601342
- OMIM disease information:
Click on [?] for more information.
