DREDD (Drosophila melanogaster)
Description [+]
- Synonyms: DREDD, CASPASE-8, CASPASE-8 SUBUNIT P15, CASPASE-8 SUBUNIT P10, DCP2
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: CASPASE
- Process: immunity,
- Pathways: TNF/NF-kappaB signaling,
- Criteria: manually curated
- Curator comment:
- WIKI: DREDD-D_melanogaster
References [+]
- Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.
- Chen P, Rodriguez A, Erskine R, Thach T, Abrams JM
- Caspases are widely conserved proteases considered to be essential effectors of apoptosis. We identified a novel Drosophila gene, dredd, which shares extensive homology to all members of the caspase gene family. Cells specified for programmed death in development exhibit a striking accumulation of dredd RNA that requires signaling by the death activators REAPER, GRIM, and HID. Furthermore, directed misexpression of each activator was sufficient to drive ectopic accumulation of dredd RNA. Heterozygosity at the dredd locus suppressed apoptosis in transgenic models of reaper- and grim-induced cell killing, demonstrating that levels of dredd product can modulate signaling triggered by these death activators. Finally, expression of REAPER, GRIM, and HID was found to trigger processing of DREDD protein precursor through a mechanism that is insensitive to, and upstream of, known caspase inhibitors. Taken together, these observations establish mechanistic connections between activators of apoptosis and a new downstream death effector in Drosophila. Dev Biol. 1998 Sep 15;201(2):202-16.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
| Source | Domain Name | Start | End |
|---|---|---|---|
| PFAM A | Peptidase_C14 | 259 | 490 |
Protein sequence [+]
Dredd | Drosophila melanogaster | 7227 | length:494
MAGSNLLIHLDTIDQNDLIYVERDMNFAQKVGLCFLLYGDDHSDATYILQKLLAMTRSDF
PQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVH
PLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIK
LGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQ
QSYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLI
EVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEEAVYASNSIAMK
ITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELFRIDVTTVSPDQHIDMLRAMS
TVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNV
KSTFRQHVYFPPRL
PQSDLLIKFAKSRPETWRRHLVEALCIIGARKVLRRLGFCWQELRMHYLPHIAGITLHVH
PLLKSLYRMCEELSLVQSGRLLLDVREKVESQQAGDPLRFYDPAYLEIFLLDWLTRRSIK
LGDINAAGSDVQLLVGHLKSNGLQAQANLLKDTIISNAPEPDAAGTAAMAVKQEIESDNQ
QSYCSTQIDALKLTRENAGIALIINQQKFHRNVSRDNMKFLSPDPLRRRDGTDVDKERLI
EVFSSMGYNVEAYDNVDHMGIIERIRSACDRSLVRDSLVVFILSHGFEEAVYASNSIAMK
ITDIEDLLCSYDTLYYKPKLLIIQACQEKLVHKKKPNELFRIDVTTVSPDQHIDMLRAMS
TVNGYAALRHTQTGSWFIGSLCDAIDRRSASEHIADILTIVTNEVSKKRGSNDESMVPNV
KSTFRQHVYFPPRL
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:
Explore tree at phylomeDB: Click here.
Homologs list [+]
| Name | Relationship | Species |
|---|---|---|
| A_aegypti_AAEL014148-PA | orthology | Aedes |
| CASPL1 | orthology | Anopheles |
| A_aegypti_AAEL003444-PA | paralogy | Aedes |
| A_aegypti_AAEL014348-PA | paralogy | Aedes |
| CASPS8 | paralogy | Anopheles |
| CASPL2 | paralogy | Anopheles |
| CASPS7 | paralogy | Anopheles |
| CASPS5 | paralogy | Anopheles |
| CASP10 | paralogy | Chicken |
| NP_990056.1 | paralogy | Chicken |
| NP_001038154.1 | paralogy | Chicken |
| NP_989923.1 | paralogy | Chicken |
| CASP2_CHICK | paralogy | Chicken |
| CASP7 | paralogy | Chicken |
| NP_990057.1 | paralogy | Chicken |
| CASP7 | paralogy | Chimpanzee |
| CASP6 | paralogy | Chimpanzee |
| XR_025516.1 | paralogy | Chimpanzee |
| CASP2 | paralogy | Chimpanzee |
| CASP3_PANTR | paralogy | Chimpanzee |
| CASP8 | paralogy | Chimpanzee |
| C_intestinalis_ENSCINP00000024485 | paralogy | Ciona |
| C_intestinalis_ENSCINP00000002956 | paralogy | Ciona |
| C_intestinalis_ENSCINP00000007986 | paralogy | Ciona |
| C_intestinalis_ENSCINP00000003204 | paralogy | Ciona |
| IPI00689801.3 | paralogy | Cow |
| CASP6_BOVIN | paralogy | Cow |
| NP_001039435.1 | paralogy | Cow |
| IPI00707783.1 | paralogy | Cow |
| CASP3_BOVIN | paralogy | Cow |
| CASP6 | paralogy | Dog |
| Q38JA9_CANFA | paralogy | Dog |
| CASP10 | paralogy | Dog |
| CASP7 | paralogy | Dog |
| CASP3_CANFA | paralogy | Dog |
| CASP2 | paralogy | Dog |
| Ice | paralogy | Fly |
| Dcp-1 | paralogy | Fly |
| decay | paralogy | Fly |
| T_rubripes_ENSTRUP00000024467 | paralogy | Fugu |
| CASP9 | paralogy | Fugu |
| CASP7 | paralogy | Fugu |
| T_rubripes_ENSTRUP00000024164 | paralogy | Fugu |
| CASP6 | paralogy | Fugu |
| T_rubripes_ENSTRUP00000044662 | paralogy | Fugu |
| NP_001027871.1 | paralogy | Fugu |
| G_aculeatus_ENSGACP00000016969 | paralogy | Gasterosteus |
| G_aculeatus_ENSGACP00000005791 | paralogy | Gasterosteus |
| CASP3 (4 of 4) | paralogy | Gasterosteus |
| CASP3 (2 of 4) | paralogy | Gasterosteus |
| G_aculeatus_ENSGACP00000016983 | paralogy | Gasterosteus |
| CASP2 | paralogy | Gasterosteus |
| CASP3 (1 of 4) | paralogy | Gasterosteus |
| CASP7 | paralogy | Gasterosteus |
| CASP6 | paralogy | Gasterosteus |
| CASP3 (3 of 4) | paralogy | Gasterosteus |
| CASP7 | paralogy | Gorilla |
| CASP8 | paralogy | Gorilla |
| Q3S2Z5_HORSE | paralogy | Horse |
| CASP6 | paralogy | Horse |
| CASP2 | paralogy | Horse |
| CASP8 | paralogy | Horse |
| CASP10 | paralogy | Horse |
| CASP7 | paralogy | Horse |
| CASP2 | paralogy | Human |
| CASP8 | paralogy | Human |
| CASP6 | paralogy | Human |
| CASP10 | paralogy | Human |
| CASP3 | paralogy | Human |
| CASP7 | paralogy | Human |
| CASP10 | paralogy | Lyzard |
| CASP6 | paralogy | Lyzard |
| CASP3 | paralogy | Lyzard |
| CASP2 | paralogy | Lyzard |
| CASP7 | paralogy | Lyzard |
| CASP7 | paralogy | Macaca |
| Q8SPP8_MACMU | paralogy | Macaca |
| CASP10 | paralogy | Macaca |
| Q8SPU2_MACMU | paralogy | Macaca |
| CASP8 | paralogy | Macaca |
| Q56VC9_ORYLA | paralogy | Medaka |
| Q8JIS8_ORYLA | paralogy | Medaka |
| Q8JIS9_ORYLA | paralogy | Medaka |
| CASP2 | paralogy | Monodelphis |
| CASP8 | paralogy | Monodelphis |
| CASP6 | paralogy | Monodelphis |
| CASP10 | paralogy | Monodelphis |
| NP_001033059.1 | paralogy | Monodelphis |
| NP_001033061.1 | paralogy | Monodelphis |
| Casp6 | paralogy | Mouse |
| Casp9 | paralogy | Mouse |
| Casp7 | paralogy | Mouse |
| Casp8 | paralogy | Mouse |
| Casp3 | paralogy | Mouse |
| Casp2 | paralogy | Mouse |
| Q5RCR7_PONPY | paralogy | Orangutan |
| CASP3 | paralogy | Orangutan |
| CASP7 | paralogy | Orangutan |
| CASP6 | paralogy | Orangutan |
| CASP9 | paralogy | Orangutan |
| CASP2 | paralogy | Orangutan |
| Q5RB11_PONPY | paralogy | Orangutan |
| CASP7 | paralogy | Ornithorhynchus |
| CASP8 | paralogy | Ornithorhynchus |
| CASP6 | paralogy | Ornithorhynchus |
| O_anatinus_ENSOANP00000001054 | paralogy | Ornithorhynchus |
| CASP2 | paralogy | Ornithorhynchus |
| CASP3 | paralogy | Ornithorhynchus |
| CASP10 | paralogy | Ornithorhynchus |
| CASP10 | paralogy | Rabbit |
| CASP7 | paralogy | Rabbit |
| CASP8 | paralogy | Rabbit |
| Casp9 | paralogy | Rat |
| Casp3 | paralogy | Rat |
| Casp6 | paralogy | Rat |
| Casp7 | paralogy | Rat |
| Casp2 | paralogy | Rat |
| Casp8 | paralogy | Rat |
| CASP9 | paralogy | Tetraodon |
| CASP3 | paralogy | Tetraodon |
| T_nigroviridis_ENSTNIP00000010722 | paralogy | Tetraodon |
| T_nigroviridis_ENSTNIP00000001216 | paralogy | Tetraodon |
| CASP6 | paralogy | Tetraodon |
| CASP7 | paralogy | Tetraodon |
| ced-3 | paralogy | Worm |
| csp-1 | paralogy | Worm |
| csp-2 | paralogy | Worm |
| CASP3 | paralogy | Xenopus |
| casp6 | paralogy | Xenopus |
| casp7 | paralogy | Xenopus |
| casp10 | paralogy | Xenopus |
| CASP2 | paralogy | Xenopus |
| CASP8 | paralogy | Zebra finch |
| T_guttata_ENSTGUP00000004278 | paralogy | Zebra finch |
| T_guttata_ENSTGUP00000011206 | paralogy | Zebra finch |
| CASP3 | paralogy | Zebra finch |
| T_guttata_ENSTGUP00000013612 | paralogy | Zebra finch |
| casp8l1 | paralogy | Zebrafish |
| casp6 | paralogy | Zebrafish |
| casp6l1 | paralogy | Zebrafish |
| casp3a | paralogy | Zebrafish |
| casp8l2 | paralogy | Zebrafish |
| NP_001077331.1 | paralogy | Zebrafish |
| LOC795066 | paralogy | Zebrafish |
| casp6l2 | paralogy | Zebrafish |
| A2BGE2_DANRE | paralogy | Zebrafish |
| casp7 | paralogy | Zebrafish |
| LOC100000522 | paralogy | Zebrafish |
| casp3b | paralogy | Zebrafish |
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Information from other databases [+]
- Gene info from FyBase [?] FBgn0020381
- Ensembl genome browser [?] : FBgn0020381
- Expression info from Arrayexpress [?] : FBgn0020381
- Protein expression from Protein Atlas: [?] FBgn0020381
Click on [?] for more information.
