NC (Drosophila melanogaster)
Description [+]
- Synonyms: NC, DRONC, CASPASE NC, NEDD2-LIKE CASPASE DRONC, CASPASE NC SUBUNIT 1, CASPASE NC SUBUNIT 2
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: CASPASE
- Process: apoptosis,
- Pathways:
- Criteria: manually curated
- Curator comment:
- WIKI: NC-D_melanogaster
References [+]
- DRONC, an ecdysone-inducible Drosophila caspase.
- Dorstyn L, Colussi PA, Quinn LM, Richardson H, Kumar S
- Caspases play an essential role in the execution of programmed cell death in metazoans. Although 14 caspases are known in mammals, only a few have been described in other organisms. Here we describe the identification and characterization of a Drosophila caspase, DRONC, that contains an amino terminal caspase recruitment domain. Ectopic expression of DRONC in cultured cells resulted in apoptosis, which was inhibited by the caspase inhibitors p35 and MIHA. DRONC exhibited a substrate specificity similar to mammalian caspase-2. DRONC is ubiquitously expressed in Drosophila embryos during early stages of development. In late third instar larvae, dronc mRNA is dramatically up-regulated in salivary glands and midgut before histolysis of these tissues. Exposure of salivary glands and midgut isolated from second instar larvae to ecdysone resulted in a massive increase in dronc mRNA levels. These results suggest that DRONC is an effector of steroid-mediated apoptosis during insect metamorphosis. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4307-12.
- The Drosophila caspase DRONC is regulated by DIAP1.
- Meier P, Silke J, Leevers SJ, Evan GI
- We have isolated the recently identified Drosophila caspase DRONC through its interaction with the effector caspase drICE. Ectopic expression of DRONC induces cell death in Schizosaccharomyces pombe, mammalian fibroblasts and the developing Drosophila eye. The caspase inhibitor p35 fails to rescue DRONC-induced cell death in vivo and is not cleaved by DRONC in vitro, making DRONC the first identified p35-resistant caspase. The DRONC pro-domain interacts with Drosphila inhibitor of apoptosis protein 1 (DIAP1), and co-expression of DIAP1 in the developing Drosophila eye completely reverts the eye ablation phenotype induced by pro-DRONC expression. In contrast, DIAP1 fails to rescue eye ablation induced by DRONC lacking the pro-domain, indicating that interaction of DIAP1 with the pro-domain of DRONC is required for suppression of DRONC-mediated cell death. Heterozygosity at the diap1 locus enhances the pro-DRONC eye phenotype, consistent with a role for endogenous DIAP1 in suppression of DRONC activation. Both heterozygosity at the dronc locus and expression of dominant-negative DRONC mutants suppress the eye phenotype caused by reaper (RPR) and head involution defective (HID), consistent with the idea that DRONC functions in the RPR and HID pathway. EMBO J. 2000 Feb 15;19(4):598-611.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Peptidase_C14 | 196 | 443 |
Protein sequence [+]
Nc | Drosophila melanogaster | 7227 | length:450
MQPPELEIGMPKRHREHIRKNLNILVEWTNYERLAMECVQQGILTVQMLRNTQDLNGKPF
NMDEKDVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFIS
LNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGD
SAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNV
NQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQT
AKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTN
VPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNK
RTKKGSMQTGAYDNLGFNKKLYFNPGFFNE
NMDEKDVRVEQHRRLLLKITQRGPTAYNLLINALRNINCLDAAVLLESVDESDSRPPFIS
LNERRTSRKSADIVDTPSPEASEGPCVSKLRNEPLGALTPYVGVVDGPEVKKSKKIHGGD
SAILGTYKMQSRFNRGVLLMVNIMDYPDQNRRRIGAEKDSKSLIHLFQELNFTIFPYGNV
NQDQFFKLLTMVTSSSYVQNTECFVMVLMTHGNSVEGKEKVEFCDGSVVDMQKIKDHFQT
AKCPYLVNKPKVLMFPFCRGDEYDLGHPKNQGNLMEPVYTAQEEKWPDTQTEGIPSPSTN
VPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFCQVMADHAHDTDLEDILKKTSEAVGNK
RTKKGSMQTGAYDNLGFNKKLYFNPGFFNE
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
A_aegypti_AAEL011562-PA | orthology | Aedes |
CASPL2 | orthology | Anopheles |
T_rubripes_ENSTRUP00000035020 | orthology | Fugu |
csp-2 | orthology | Worm |
A_aegypti_AAEL003444-PA | paralogy | Aedes |
CASPS6 | paralogy | Anopheles |
CASPS1 | paralogy | Anopheles |
CASPS2 | paralogy | Anopheles |
CASPS4 | paralogy | Anopheles |
CASPS3 | paralogy | Anopheles |
CASPS14 | paralogy | Anopheles |
A_gambiae_AGAP012945-PA | paralogy | Anopheles |
NP_990057.1 | paralogy | Chicken |
CASP2_CHICK | paralogy | Chicken |
Q90WU0_CHICK | paralogy | Chicken |
CASP10 | paralogy | Chicken |
NP_001038154.1 | paralogy | Chicken |
NP_989923.1 | paralogy | Chicken |
CASP7 | paralogy | Chicken |
NP_990056.1 | paralogy | Chicken |
CASP7 | paralogy | Chimpanzee |
CASP8 | paralogy | Chimpanzee |
CASP6 | paralogy | Chimpanzee |
CASP2 | paralogy | Chimpanzee |
XR_025516.1 | paralogy | Chimpanzee |
CASP3_PANTR | paralogy | Chimpanzee |
CASP9 | paralogy | Chimpanzee |
C_intestinalis_ENSCINP00000002956 | paralogy | Ciona |
C_intestinalis_ENSCINP00000003204 | paralogy | Ciona |
C_intestinalis_ENSCINP00000007986 | paralogy | Ciona |
C_intestinalis_ENSCINP00000024485 | paralogy | Ciona |
IPI00704513.4 | paralogy | Cow |
IPI00689801.3 | paralogy | Cow |
CASP6_BOVIN | paralogy | Cow |
CASP3_BOVIN | paralogy | Cow |
IPI00707783.1 | paralogy | Cow |
NP_001039435.1 | paralogy | Cow |
CASP2 | paralogy | Dog |
CASP7 | paralogy | Dog |
CASP6 | paralogy | Dog |
Q38JA9_CANFA | paralogy | Dog |
CASP10 | paralogy | Dog |
Q45T68_CANFA | paralogy | Dog |
CASP3_CANFA | paralogy | Dog |
Ice | paralogy | Fly |
Dcp-1 | paralogy | Fly |
CASP6 | paralogy | Fugu |
CASP7 | paralogy | Fugu |
CASP2 | paralogy | Fugu |
NP_001027871.1 | paralogy | Fugu |
CASP9 | paralogy | Fugu |
CASP9 | paralogy | Gasterosteus |
CASP7 | paralogy | Gasterosteus |
CASP2 | paralogy | Gasterosteus |
CASP3 (4 of 4) | paralogy | Gasterosteus |
CASP6 | paralogy | Gasterosteus |
CASP8 | paralogy | Gorilla |
CASP9 | paralogy | Gorilla |
CASP7 | paralogy | Gorilla |
CASP2 | paralogy | Horse |
CASP8 | paralogy | Horse |
CASP6 | paralogy | Horse |
CASP7 | paralogy | Horse |
CASP9 | paralogy | Horse |
Q3S2Z5_HORSE | paralogy | Horse |
CASP10 | paralogy | Horse |
CASP6 | paralogy | Human |
CASP10 | paralogy | Human |
CASP3 | paralogy | Human |
CASP2 | paralogy | Human |
CASP8 | paralogy | Human |
CASP7 | paralogy | Human |
CASP9 | paralogy | Human |
CASP2 | paralogy | Lyzard |
CASP7 | paralogy | Lyzard |
CASP6 | paralogy | Lyzard |
CASP10 | paralogy | Lyzard |
CASP3 | paralogy | Lyzard |
CASP7 | paralogy | Macaca |
Q8SPU2_MACMU | paralogy | Macaca |
Q8SPP8_MACMU | paralogy | Macaca |
CASP8 | paralogy | Macaca |
CASP10 | paralogy | Macaca |
CASP9 | paralogy | Macaca |
CASP9 | paralogy | Medaka |
Q8JIS9_ORYLA | paralogy | Medaka |
CASP2 | paralogy | Medaka |
CASP2 | paralogy | Monodelphis |
CASP9 | paralogy | Monodelphis |
NP_001033059.1 | paralogy | Monodelphis |
NP_001033061.1 | paralogy | Monodelphis |
CASP6 | paralogy | Monodelphis |
CASP8 | paralogy | Monodelphis |
CASP10 | paralogy | Monodelphis |
Casp7 | paralogy | Mouse |
Casp8 | paralogy | Mouse |
Casp6 | paralogy | Mouse |
Casp9 | paralogy | Mouse |
Casp2 | paralogy | Mouse |
Casp3 | paralogy | Mouse |
CASP9 | paralogy | Orangutan |
CASP7 | paralogy | Orangutan |
Q5RB11_PONPY | paralogy | Orangutan |
Q5RCR7_PONPY | paralogy | Orangutan |
CASP6 | paralogy | Orangutan |
CASP3 | paralogy | Orangutan |
CASP2 | paralogy | Orangutan |
CASP7 | paralogy | Ornithorhynchus |
CASP2 | paralogy | Ornithorhynchus |
CASP6 | paralogy | Ornithorhynchus |
CASP9 | paralogy | Ornithorhynchus |
CASP3 | paralogy | Ornithorhynchus |
CASP10 | paralogy | Rabbit |
CASP8 | paralogy | Rabbit |
CASP7 | paralogy | Rabbit |
Casp6 | paralogy | Rat |
Casp3 | paralogy | Rat |
Casp8 | paralogy | Rat |
Casp9 | paralogy | Rat |
Casp2 | paralogy | Rat |
Casp7 | paralogy | Rat |
T_nigroviridis_ENSTNIP00000001216 | paralogy | Tetraodon |
CASP9 | paralogy | Tetraodon |
CASP6 | paralogy | Tetraodon |
CASP7 | paralogy | Tetraodon |
ced-3 | paralogy | Worm |
csp-1 | paralogy | Worm |
CASP2 | paralogy | Xenopus |
casp7 | paralogy | Xenopus |
casp6 | paralogy | Xenopus |
CASP8 | paralogy | Zebra finch |
T_guttata_ENSTGUP00000011206 | paralogy | Zebra finch |
T_guttata_ENSTGUP00000013612 | paralogy | Zebra finch |
CASP9 | paralogy | Zebra finch |
T_guttata_ENSTGUP00000004278 | paralogy | Zebra finch |
CASP3 | paralogy | Zebra finch |
casp3a | paralogy | Zebrafish |
casp7 | paralogy | Zebrafish |
casp8l2 | paralogy | Zebrafish |
casp6l1 | paralogy | Zebrafish |
D_rerio_ENSDARP00000047019 | paralogy | Zebrafish |
casp6 | paralogy | Zebrafish |
NP_001077331.1 | paralogy | Zebrafish |
casp3b | paralogy | Zebrafish |
LOC100000522 | paralogy | Zebrafish |
A2BGE2_DANRE | paralogy | Zebrafish |
LOC795066 | paralogy | Zebrafish |
casp2 | paralogy | Zebrafish |
casp6l2 | paralogy | Zebrafish |
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0007165 | signal transduction | biological_proccess | IEA |
GO:0046068 | cGMP metabolic process | biological_proccess | IDA |
GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity | mollecular_function | IDA |
GO:0003824 | catalytic activity | mollecular_function | IEA |
GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IPI |
GO:0016787 | hydrolase activity | mollecular_function | IEA |
GO:0005886 | plasma membrane | cell_component | IEA |
GO:0016020 | membrane | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from FyBase [?] FBgn0026404
- Ensembl genome browser [?] : FBgn0026404
- Expression info from Arrayexpress [?] : FBgn0026404
- Protein expression from Protein Atlas: [?] FBgn0026404
Click on [?] for more information.