JAFRAC2 (Drosophila melanogaster)
Description [+]
- Synonyms: JAFRAC2, THIOREDOXIN PEROXIDASE 2, GH25379P, SECRETABLE THIOREDOXIN PEROXIDASE
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: IAP antagonist
- Process: apoptosis,
- Pathways:
- Criteria: manually curated
- Curator comment:
- Human ortholog(s): PRDX4
- WIKI: JAFRAC2-D_melanogaster
References [+]
- Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1.
- Tenev T, Zachariou A, Wilson R, Paul A, Meier P
- Members of the Inhibitor of Apoptosis Protein (IAP) family are essential for cell survival in Drosophila and appear to neutralize the cell death machinery by binding to and ubiquitylating pro-apoptotic caspases. Cell death is triggered when "Reaper-like" proteins bind to IAPs and liberate caspases from IAPs. We have identified the thioredoxin peroxidase Jafrac2 as an IAP-interacting protein in Drosophila cells that harbours a conserved N-terminal IAP-binding motif. In healthy cells, Jafrac2 resides in the endoplasmic reticulum but is rapidly released into the cytosol following induction of apoptosis. Mature Jafrac2 interacts genetically and biochemically with DIAP1 and promotes cell death in tissue culture cells and the Drosophila developing eye. In common with Rpr, Jafrac2-mediated cell death is contingent on DIAP1 binding because mutations that abolish the Jafrac2-DIAP1 interaction suppress the eye phenotype caused by Jafrac2 expression. We show that Jafrac2 displaces Dronc from DIAP1 by competing with Dronc for the binding of DIAP1, consistent with the idea that Jafrac2 triggers cell death by liberating Dronc from DIAP1-mediated inhibition. EMBO J. 2002 Oct 1;21(19):5118-29.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | AhpC-TSA | 52 | 185 |
PFAM A | 1-cysPrx_C | 195 | 238 |
Protein sequence [+]
Jafrac2 | Drosophila melanogaster | 7227 | length:242
MSKYLSVLLLSAALVGAAKPEDNESCYSFAGGSVYPDQPKGDHQLQYTKAVISKPAPQFE
GTAVVNKEIVKLSLSQYLGKYVVLLFYPLDFTFVCPTEIIAFSDRIAEFKKIKTEVIGVS
VDSHFTHLAWINTPRKEGGLGDVKIPLLSDLTHKISKDYGVYLESSGHALRGLFIIDQTG
VLRQITMNDLPVGRSVDETIRLVQAFQYTDTHGEVCPAGWRPGADTIVPNPEEKTKYFAK
NN
GTAVVNKEIVKLSLSQYLGKYVVLLFYPLDFTFVCPTEIIAFSDRIAEFKKIKTEVIGVS
VDSHFTHLAWINTPRKEGGLGDVKIPLLSDLTHKISKDYGVYLESSGHALRGLFIIDQTG
VLRQITMNDLPVGRSVDETIRLVQAFQYTDTHGEVCPAGWRPGADTIVPNPEEKTKYFAK
NN
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
A_aegypti_AAEL014548-PA | orthology | Aedes |
TPX3 | orthology | Anopheles |
PRDX4 | orthology | Chicken |
PRDX4 | orthology | Chimpanzee |
C_intestinalis_ENSCINP00000013246 | orthology | Ciona |
PRDX4_BOVIN | orthology | Cow |
PRDX4 | orthology | Dog |
PRDX4 | orthology | Fugu |
PRDX4 | orthology | Gasterosteus |
PRDX4 | orthology | Horse |
PRDX4 | orthology | Human |
PRDX4 | orthology | Lyzard |
PRDX4 | orthology | Macaca |
PRDX4 | orthology | Medaka |
PRDX4 | orthology | Monodelphis |
Prdx4 | orthology | Mouse |
PRDX4 | orthology | Orangutan |
PRDX4 | orthology | Ornithorhynchus |
PRDX4 | orthology | Rabbit |
Prdx4 | orthology | Rat |
PRDX4 | orthology | Tetraodon |
prdx-2 | orthology | Worm |
prdx4 | orthology | Xenopus |
TSA2 | orthology | Yeast |
TSA1 | orthology | Yeast |
PRDX4 | orthology | Zebra finch |
NP_001082894.1 | orthology | Zebrafish |
A_aegypti_AAEL002309-PA | paralogy | Aedes |
Q8WSF6_AEDAE | paralogy | Aedes |
A_aegypti_AAEL009051-PA | paralogy | Aedes |
A_aegypti_AAEL013528-PA | paralogy | Aedes |
TPX1 | paralogy | Anopheles |
TPX5 | paralogy | Anopheles |
TPX2 | paralogy | Anopheles |
TPX4 | paralogy | Anopheles |
PRDX6_CHICK | paralogy | Chicken |
PRDX3 | paralogy | Chicken |
PRDX1 | paralogy | Chicken |
PRDX1 | paralogy | Chimpanzee |
XR_022030.1 | paralogy | Chimpanzee |
PRDX3 | paralogy | Chimpanzee |
PRDX2 | paralogy | Chimpanzee |
NP_001027810.1 | paralogy | Ciona |
IPI00712841.3 | paralogy | Cow |
PRDX1_BOVIN | paralogy | Cow |
PRDX6_BOVIN | paralogy | Cow |
PRDX3_BOVIN | paralogy | Cow |
PRDX2_BOVIN | paralogy | Cow |
PRDX1 | paralogy | Dog |
PRDX3 | paralogy | Dog |
PRDX6 | paralogy | Dog |
PRDX2 | paralogy | Dog |
Prx2540-1 | paralogy | Fly |
CG12896 | paralogy | Fly |
Jafrac1 | paralogy | Fly |
CG6888 | paralogy | Fly |
Prx6005 | paralogy | Fly |
Prx5037 | paralogy | Fly |
Prx2540-2 | paralogy | Fly |
PRDX2 (2 of 2) | paralogy | Fugu |
PRDX6 (1 of 2) | paralogy | Fugu |
PRDX2 (1 of 2) | paralogy | Fugu |
PRDX6 (2 of 2) | paralogy | Fugu |
PRDX3 | paralogy | Fugu |
PRDX3 | paralogy | Gasterosteus |
PRDX6 (1 of 2) | paralogy | Gasterosteus |
PRDX2 (1 of 2) | paralogy | Gasterosteus |
PRDX6 (2 of 2) | paralogy | Gasterosteus |
PRDX2 (2 of 2) | paralogy | Gasterosteus |
PRDX1 | paralogy | Gorilla |
PRDX2 | paralogy | Gorilla |
E_caballus_ENSECAP00000001933 | paralogy | Horse |
E_caballus_ENSECAP00000006859 | paralogy | Horse |
PRDX2 | paralogy | Horse |
PRDX3 | paralogy | Horse |
PRDX6 | paralogy | Horse |
PRDX1 | paralogy | Human |
PRDX3 | paralogy | Human |
PRDX2 | paralogy | Human |
PRDX6 | paralogy | Human |
PRDX2 | paralogy | Lyzard |
PRDX1 | paralogy | Lyzard |
PRDX6 | paralogy | Lyzard |
PRDX3 | paralogy | Lyzard |
PRDX2 | paralogy | Macaca |
PRDX1 | paralogy | Macaca |
PRDX3 | paralogy | Macaca |
PRDX6 | paralogy | Macaca |
M_mulatta_ENSMMUP00000036447 | paralogy | Macaca |
PRDX6 (2 of 2) | paralogy | Medaka |
PRDX2 (1 of 2) | paralogy | Medaka |
PRDX3 | paralogy | Medaka |
PRDX2 (2 of 2) | paralogy | Medaka |
PRDX6 (1 of 2) | paralogy | Medaka |
PRDX6 | paralogy | Monodelphis |
PRDX2 | paralogy | Monodelphis |
PRDX3 | paralogy | Monodelphis |
PRDX1 | paralogy | Monodelphis |
Prdx3 | paralogy | Mouse |
Prdx1 | paralogy | Mouse |
Prdx6-rs1 | paralogy | Mouse |
Prdx6 | paralogy | Mouse |
Prdx2 | paralogy | Mouse |
PRDX6 | paralogy | Orangutan |
PRDX1 | paralogy | Orangutan |
PRDX3_PONPY | paralogy | Orangutan |
PRDX2_PONPY | paralogy | Orangutan |
P_pygmaeus_ENSPPYP00000017052 | paralogy | Orangutan |
PRDX6 | paralogy | Ornithorhynchus |
PRDX3 | paralogy | Ornithorhynchus |
PRDX2 | paralogy | Ornithorhynchus |
PRDX1 | paralogy | Ornithorhynchus |
PRDX2 | paralogy | Rabbit |
PRDX1 | paralogy | Rabbit |
PRDX6 | paralogy | Rabbit |
PRDX3 | paralogy | Rabbit |
Prdx2 | paralogy | Rat |
Prdx3 | paralogy | Rat |
Prdx1 | paralogy | Rat |
R_norvegicus_ENSRNOP00000023972 | paralogy | Rat |
LOC502175 | paralogy | Rat |
Prdx6 | paralogy | Rat |
R_norvegicus_ENSRNOP00000052225 | paralogy | Rat |
R_norvegicus_ENSRNOP00000054256 | paralogy | Rat |
R_norvegicus_ENSRNOP00000054377 | paralogy | Rat |
PRDX2 (2 of 2) | paralogy | Tetraodon |
PRDX3 | paralogy | Tetraodon |
PRDX6 (2 of 2) | paralogy | Tetraodon |
PRDX2 (1 of 2) | paralogy | Tetraodon |
PRDX6 (1 of 2) | paralogy | Tetraodon |
prdx-3 | paralogy | Worm |
prdx-6 | paralogy | Worm |
prdx6-2 | paralogy | Xenopus |
prdx1 | paralogy | Xenopus |
prdx2 | paralogy | Xenopus |
prdx3 | paralogy | Xenopus |
X_tropicalis_ENSXETP00000024196 | paralogy | Xenopus |
PRX1 | paralogy | Yeast |
B5G0L9_TAEGU | paralogy | Zebra finch |
PRDX3 | paralogy | Zebra finch |
T_guttata_ENSTGUP00000017537 | paralogy | Zebra finch |
prdx2 | paralogy | Zebrafish |
prdx6 | paralogy | Zebrafish |
PRDX6 (2 of 2) | paralogy | Zebrafish |
zgc:110343 | paralogy | Zebrafish |
prdx3 | paralogy | Zebrafish |
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Information from other databases [+]
- Gene info from FyBase [?] FBgn0040308
- Ensembl genome browser [?] : FBgn0040308
- Expression info from Arrayexpress [?] : FBgn0040308
- Protein expression from Protein Atlas: [?] FBgn0040308
Click on [?] for more information.