HIPK (Drosophila melanogaster)
Description [+]
- Synonyms: HIPK, HIPK, HOMEODOMAIN INTERACTING PROTEIN KINASE
- Species: Metazoa;Bilateria;Ecdysozoa;Arthropoda;Hexapoda; Drosophila melanogaster
- Short gene description: NA
- Family: other
- Process: cell death (other),
- Pathways:
- Criteria: manually curated
- Curator comment:
- Human ortholog(s): HIPK1 HIPK3 HIPK2
- WIKI: HIPK-D_melanogaster
References [+]
- A collective form of cell death requires homeodomain interacting protein kinase.
- Link N, Chen P, Lu WJ, Pogue K, Chuong A, Mata M, Checketts J, Abrams JM
- We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers. J Cell Biol. 2007 Aug 13;178(4):567-74. Epub 2007 Aug 6.
Structure & Sequence [+]
Pfam domains:
(Pfam is a large collection of protein families.)
Source | Domain Name | Start | End |
---|---|---|---|
PFAM A | Pkinase | 192 | 520 |
PFAM A | Pkinase_Tyr | 192 | 428 |
Protein sequence [+]
hipk | Drosophila melanogaster | 7227 | length:1340
MKTSYPPKASDFVDYAVAGGGGSGFCSGLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQ
QQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSA
AAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLV
QHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSIL
SRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQ
VLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYY
RAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNS
ASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEG
GQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQM
MEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQI
YNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQY
VNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPL
FNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPP
HQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHV
PVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQ
PTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSR
SSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQ
QQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLP
HIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYV
APSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPG
SVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYR
RPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQ
VAASKHAAHFAPTNIWYGAE
QQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGCVDSYNSSHGPPVQQDSSA
AAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGADGDYQLV
QHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSIL
SRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQ
VLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYY
RAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNS
ASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEG
GQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQM
MEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQI
YNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQY
VNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPL
FNVEEIYPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPP
HQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHV
PVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQ
PTITIHDTPSPTAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSR
SSAHQQPHPHPQQQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQ
QQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLP
HIPTKQEPAEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYV
APSVAPPLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPG
SVGLPGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYR
RPTVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQ
VAASKHAAHFAPTNIWYGAE
Structure links:
Evolution [+]
View protein alignment and tree with Jalview:  
Explore tree at phylomeDB:   Click here.
Homologs list [+]
Name | Relationship | Species |
---|---|---|
A_aegypti_AAEL003731-PA | orthology | Aedes |
A_gambiae_AGAP007342-PA | orthology | Anopheles |
HIPK1 | orthology | Chicken |
Q8UVD4_CHICK | orthology | Chicken |
HIPK3 | orthology | Chicken |
HIPK1 | orthology | Chimpanzee |
HIPK3 | orthology | Chimpanzee |
HIPK2 | orthology | Chimpanzee |
NP_001103468.1 | orthology | Cow |
IPI00842056.2 | orthology | Cow |
HIPK1 | orthology | Dog |
HIPK3 | orthology | Dog |
HIPK2 | orthology | Dog |
HIPK3 (2 of 2) | orthology | Fugu |
HIPK3 (1 of 2) | orthology | Fugu |
T_rubripes_ENSTRUP00000020840 | orthology | Fugu |
T_rubripes_ENSTRUP00000027188 | orthology | Fugu |
G_aculeatus_ENSGACP00000017894 | orthology | Gasterosteus |
HIPK3 (1 of 2) | orthology | Gasterosteus |
HIPK2 | orthology | Gorilla |
HIPK3 | orthology | Horse |
HIPK1 | orthology | Horse |
HIPK2 | orthology | Horse |
HIPK3 | orthology | Human |
HIPK1 | orthology | Human |
HIPK2 | orthology | Human |
HIPK2 | orthology | Lyzard |
HIPK3 | orthology | Lyzard |
HIPK1 | orthology | Lyzard |
HIPK2 | orthology | Macaca |
O_latipes_ENSORLP00000020125 | orthology | Medaka |
HIPK3 (2 of 2) | orthology | Medaka |
HIPK3 | orthology | Monodelphis |
HIPK1 | orthology | Monodelphis |
HIPK2 | orthology | Monodelphis |
Hipk2 | orthology | Mouse |
Hipk1 | orthology | Mouse |
Hipk3 | orthology | Mouse |
HIPK3 | orthology | Orangutan |
HIPK2 | orthology | Orangutan |
HIPK3 | orthology | Ornithorhynchus |
Hipk1_predicted | orthology | Rat |
NP_001102092.1 | orthology | Rat |
Hipk3 | orthology | Rat |
T_nigroviridis_ENSTNIP00000022455 | orthology | Tetraodon |
hipk1 | orthology | Xenopus |
HIPK2 | orthology | Zebra finch |
HIPK3 | orthology | Zebra finch |
HIPK1 | orthology | Zebra finch |
si:dkey-16j24.2 | orthology | Zebrafish |
si:dkey-261h15.1 | orthology | Zebrafish |
A_gambiae_AGAP004833-PA | paralogy | Anopheles |
DYRK3 | paralogy | Gasterosteus |
DYRK2 | paralogy | Gasterosteus |
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Gene Ontology [+]
GO id | Name | Ontology type | Evidence |
---|---|---|---|
GO:0007186 | G-protein coupled receptor protein signaling pathway | biological_proccess | IEA |
GO:0006468 | protein amino acid phosphorylation | biological_proccess | IEA |
GO:0007369 | gastrulation | biological_proccess | NAS |
GO:0007370 | ventral furrow formation | biological_proccess | IGI |
GO:0045839 | negative regulation of mitosis | biological_proccess | IGI |
GO:0051726 | regulation of cell cycle | biological_proccess | IMP |
GO:0004672 | protein kinase activity | mollecular_function | IEA |
GO:0005515 | protein binding | mollecular_function | IPI |
GO:0005524 | ATP binding | mollecular_function | IEA |
GO:0004674 | protein serine/threonine kinase activity | mollecular_function | IEA |
GO:0016021 | integral to membrane | cell_component | IEA |
Check GO Evidence Codes here
Information from other databases [+]
- Gene info from FyBase [?] FBgn0035142
- Ensembl genome browser [?] : FBgn0035142
- Expression info from Arrayexpress [?] : FBgn0035142
- Protein expression from Protein Atlas: [?] FBgn0035142
Click on [?] for more information.