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UNC-51   (Caenorhabditis elegans)

Description [+]
  • Synonyms: UNC-51
  • Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
  • Short gene description: unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins. unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration. in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14. in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals. UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles. in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. [Source: WormBase]
  • Family: Null
  • Process:
  • Pathways:
  • Criteria: homology search
  • Curator comment: Null
  • WIKI: UNC-51-C_elegans
Structure & Sequence [+]
Evolution [+]
Information from other databases [+]