UNC-57 (Caenorhabditis elegans)
Description [+]
- Synonyms: UNC-57
- Species: Metazoa;Bilateria;Ecdysozoa;Nematoda; Caenorhabditis elegans
- Short gene description: unc-57 encodes an ortholog of endophilin A that is required for synaptic vesicle endocytosis. UNC-57 is expressed in all neurons, at synapses and neuromuscular junctions, and (weakly) in the spermetheca. like other endophilins, UNC-57 has a large BAR domain, an N-terminal coiled-coil domain within the BAR domain, and a C-terminal SH3 domain. UNC-57 protein is necessary for proper localization of UNC-26 (synaptojanin) protein, which in turn is needed for endocytosis. unc-57 and unc-26 mutants are morphologically, ultrastructurally, and electrophysiologically similar both to one another and to double mutants, indicating that UNC-57 and UNC-26 act in a single genetic pathway. [Source: WormBase]
- Family: Null
- Process:
- Pathways:
- Criteria: homology search
- Curator comment: Null
- WIKI: UNC-57-C_elegans
