10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ R_norvegicus_ENSRNOP00000008319 -M-GC----------------------------------------------DRNCGLIT--------G-------------------------------AVIGAVLAVF--GGI------ R_norvegicus_ENSRNOP00000058398 -M-GC----------------------------------------------DLNCGLIT--------G-------------------------------AIIGAVLAVF--GGI------ C_familiaris_ENSCAFP00000009599 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLALL--GGI------ P_pygmaeus_ENSPPYP00000020018 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAILAVF--GGI------ P_troglodytes_ENSPTRP00000033093 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ B_taurus_ENSBTAP00000023750 -M-GC----------------------------------------------NRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ H_sapiens_ENSP00000308165 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ E_caballus_ENSECAP00000013084 -M-GC----------------------------------------------DRNCGLIT--------G-------------------------------AVIGAVLAVL--GGI------ M_domestica_ENSMODP00000021313 -M-GC----------------------------------------------DRNCGLIT--------G-------------------------------AVIGGVLAVL--GGI------ B_taurus_ENSBTAP00000018902 -M-GC----------------------------------------------DRNCGLVT--------G-------------------------------AVIGAVVALF--GGI------ O_anatinus_ENSOANP00000005521 -M-GC----------------------------------------------NRNCGLIT--------G-------------------------------AVVGAVLAIL--GGV------ G_gallus_ENSGALP00000013734 -M-TC----------------------------------------------NRSCGLLT--------G-------------------------------AVIGAVLAIF--GGV------ O_cuniculus_ENSOCUP00000002156 ---GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ T_guttata_ENSTGUP00000002704 -M-GC----------------------------------------------NRNCGLLT--------G-------------------------------AIIGAVLAIF--GGV------ A_carolinensis_ENSACAP00000015615 -M-GS----------------------------------------------CQNVALLS--------G-------------------------------AVIGAVLAIL--GGA------ X_tropicalis_ENSXETP00000017231 -M-CC----------------------------------------------STKCWLIV--------G-------------------------------SVIGGLLAIL--GGI------ T_rubripes_ENSTRUP00000041076 -MGCC----------------------------------------------NVRCGLIA--------G-------------------------------AVIGAVVAIL--GGI------ D_rerio_ENSDARP00000050752 -MTCC----------------------------------------------DQRCALIT--------G-------------------------------AVLGALIALL--GGI------ O_latipes_ENSORLP00000020106 -MGCC----------------------------------------------NRRCGLIA--------G-------------------------------AVFGAVVTIL--GGI------ T_nigroviridis_ENSTNIP00000014345 ---CC----------------------------------------------SVRCGLAA--------G-------------------------------AALGALVAVL--GGI------ G_aculeatus_ENSGACP00000026365 -MGCC----------------------------------------------NRRCGLIA--------G-------------------------------AVIGAAVAIL--GGV------ G_gorilla_ENSGGOP00000005986 -M-GC----------------------------------------------DRNCGLIA--------G-------------------------------AVIGAVLAVF--GGI------ X_tropicalis_ENSXETP00000017237 -----------------------------------------------------------------------------------------------------IGGLFAVV--GIV------ T_guttata_ENSTGUP00000001744 ---------------------------------------------------MKSLCLVTV-------------------------------------GVLAMTLLIASI--SLL------ X_tropicalis_ENSXETP00000052043 ---------------------------------------------------MVKWAVFGT-------------------------------------AAVSVTLLIVSI--VLL------ M_mulatta_ENSMMUP00000027514 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ G_gallus_ENSGALP00000018715 ---------------------------------------------------MRSLCLVTV-------------------------------------GVLALTLLIASI--SLL------ G_aculeatus_ENSGACP00000022821 -------------------------------------------------MQLKSCCIYSI-------------------------------------GVFSILLLISGI--VLV------ H_sapiens_ENSP00000264896 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ O_latipes_ENSORLP00000012225 ---------------------------------------------------LKTCCVYGT-------------------------------------GVFSMLMLIVGI--ALV------ O_anatinus_ENSOANP00000014317 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000027814 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ M_domestica_ENSMODP00000037525 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000016592 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ T_rubripes_ENSTRUP00000042953 -------------------------------------------------MTRRSCAIYA----------------------------------T---GIVSAHLLIVGI--ALV------ R_norvegicus_ENSRNOP00000003052 ---------------------------------------------------MARCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ O_latipes_ENSORLP00000001610 ------------------------------------------------------------------------------------MGVNKARLTA---GFIVAGVLMVFF--GTV------ D_rerio_ENSDARP00000023056 -------------------------------------------------MTRRSCTIYA----------------------------------T---GIVCAHLLILGI--ALL------ P_troglodytes_ENSPTRP00000009553 ----------------------------------------------------------------------------------MGCSAKARWAAG---ALGVAGLLCAVL--GAV------ H_sapiens_ENSP00000261693 ----------------------------------------------------------------------------------MGCSAKARWAAG---ALGVAGLLCAVL--GAV------ M_musculus_ENSMUSP00000031377 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ O_latipes_ENSORLP00000008151 -------------------------------------------------MTRRSYALYA----------------------------------V---GGICGTLLAVGI--GLL------ T_nigroviridis_ENSTNIP00000018658 -------------------------------------------------MTRRSCAIYA----------------------------------TVVAALIVVVVLIAGI--ALA------ G_gallus_ENSGALP00000004761 --------------------------------------------------------------------------------ALRAMVAAGRRVAV---GLGAVGAVCLLL--GGC------ T_rubripes_ENSTRUP00000019814 ----------------------------------------------VCSVTMKRCCTYTL-------------------------------------GVVSILLLVAGI--SLV------ B_taurus_ENSBTAP00000014549 ---------------------------------------------------MGRCCFYAV-------------------------------------GTLSLLLLVTSI--TLL------ T_nigroviridis_ENSTNIP00000016587 --------------------------------------------------------------------------------------VNKSKVAV---GFIVLGVLAVVF--GVI------ E_caballus_ENSECAP00000022283 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002110 ----------------------------------------------------------------------------------MARKLGGCRAPA---VVGLLGLACTVF--GIV------ T_nigroviridis_ENSTNIP00000002999 ---------------------------------------------------MRQCCFYCL-------------------------------------GLAAVLLLLAGI--VLV------ T_rubripes_ENSTRUP00000047691 ------------------------------------------------------------------------------------MAINKSKVAV---GFIVVGVLTVFF--GTL------ T_nigroviridis_ENSTNIP00000010349 -------------------------------------------------MTRRSCLVPA----------------------------------V---GIVSGLLLAVGI--GLV------ T_guttata_ENSTGUP00000005161 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019581 ----------------------------------------------------------------------------------MASKIGGPKTTV---TLGVLGLIFSVL--GGV------ A_carolinensis_ENSACAP00000014578 ----------------------------------------------------------------------------------MGGCCPPFRAAV---CLAVAGLACLAC--GIA------ C_familiaris_ENSCAFP00000012634 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018959 ----------------------------------------------------------------------------------MGNLSRARRVTA---ALGFIGLLFAVL--GII------ T_rubripes_ENSTRUP00000036580 -------------------------------------------------MTRRSCLVPA----------------------------------V---GILSALLLVVGI--GLV------ G_aculeatus_ENSGACP00000021517 -------------------------------------------------MTRRSCAIYA----------------------------------A---GIACASLLVVGI--GLV------ R_norvegicus_ENSRNOP00000001301 ----------------------------------------------------------------------------------MGVSSRARWVAL---GLGVLGLLCAAL--GVI------ P_pygmaeus_ENSPPYP00000005810 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000083242 ----------------------------------------------------------------------------------MGGSSRARWVAL---GLGALGLLFAAL--GVV------ D_rerio_ENSDARP00000076810 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012360 ---------------------------------------------------MRKLCLGTA-------------------------------------GVLAMTLLIASV--ALL------ X_tropicalis_ENSXETP00000002583 ----------------------------------------------------------------------------------SAMAGVGNKKSI---VFGVLGVLLVGV--GTL------ C_familiaris_ENSCAFP00000010357 ------------------------------------------------------------------------------------PRSHLPDALA---GPGHAGWLWAAL--AGAPTNPPH C_intestinalis_ENSCINP00000025688 ------------------------------------------------------------------------------------CKSKSCHIAL---GLIAILLIAGGAVLFGM------ T_guttata_ENSTGUP00000016695 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000458 -------------------------------------------------MTRRSCCIYV----------------------------------T---GIVSAHLLILGI--ALV------ A_gambiae_AGAP004846-PB -------------------------------------------------------------------------MYGRSNRLCAKLSSAFLRKWW---FVIAFALSLLVL--GAL------ M_mulatta_ENSMMUP00000038414 ----------------------------------------------------------------------------------MGGPTKARWAAA---ALGVAGLLCAVL--GAV------ D_melanogaster_FBpp0072308 ------------------------------------------MQLDDILHINNCKADCSSLSTTPNPKTDLVNMNGPKHKFCTKLSSTYLRKWW---ITIVVAAALIIG--GIV------ A_aegypti_AAEL000256-PA -------------------------------------------------------------------------MHGRGNRLCAKLSSAFLRKWW---FVIAFALGLLVL--GVL------ E_caballus_ENSECAP00000021856 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0110185 ----------------------------------------------------------------------------------------MIHWSL---IVSALGVCVAVL--GGY------ D_rerio_ENSDARP00000089887 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010133-PA ----------------------------------------------------------------------------------MCSPCTDFQKKF---ISLGCSSFLILL--AIT------ D_melanogaster_FBpp0079088 -----------------------------------------------------------------------------MPTQNSAMWGQKSNRKL---IIGIFGFCLGLF--GIL------ A_gambiae_AGAP004845-PA MPEMVAFYSPETVIP-----------------TTSDTEPRKPL--------KRRTSALN--------TIFYYLGLEQRSGEDAKE-NQWIRILT---FVVLFVTFITSA--IGF------ A_gambiae_AGAP005716-PA ----------------------------------------------------------------------------------------MVQCTL---IWAGIGAMMAVS--GAL------ A_aegypti_AAEL000227-PA MTEIKSTIKEQNATQQHGTSDMVHSNSAHQNNSSATSNSKKHL--------KKQTSALD--------NIAFHLGIKKADNDHIDDRNLFVTLLL---LGVLVILFIASV--TGF------ A_gambiae_AGAP003373-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071723 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077748 ---------------------------------------------------------------------------------MCCKCCGETQRKV---WVFGLGSVFLLL--GIL------ O_cuniculus_ENSOCUP00000002939 ---------------------------------------------------MGRCGFYTA-------------------------------------GTLSLLLLVTSV--TLL------ C_intestinalis_ENSCINP00000011713 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002738-PA ------------------------------------------------------------------------------------------TGTF---MLMAAGFMFIIC--GAL------ A_aegypti_AAEL009423-PA ----------------------------------------------------------------------------------MCSCCSDMQKKM---VSFGCSAFLILF--AII------ D_melanogaster_FBpp0072303 MSHTKDAEMSMPARQESDRTSAPSVTKSLTLNSTRSGVGTGNFGGYGMTNGAEKPSVLH--------MIMEALGLRNQAQNREPTSKDIGTLIM---LGVMFLLFVISV--TGF------ A_gambiae_AGAP008179-PA -------------------------------------------------------------------------------MGGCCSNWSPTGKRL---CALGSTTALCVF--ALA------ A_gambiae_AGAP005725-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018249 -------------------------------------------------MTRRSCCIYA----------------------------------T---GIVCAHLLIVGI--ALV------ A_aegypti_AAEL009432-PA ---------------------------------------------------------------------------------MMCGKCSNKAKRW---WSLGISVGICVI--AIA------ G_gorilla_ENSGGOP00000006367 ----------------------------------------------------------------------------------MGCSAKARWAAG---ALGVAGLLCVVL--GAV------ D_melanogaster_FBpp0079175 ML-------------------------------------------------SAQQEIDRGRRPANKEHQFTAPPPRLRRSSTKMTSRTRHCARL---GIVLLGICCIAS--GIY------ D_melanogaster_FBpp0112038 MGLEKHYLRYGRTARDHLLDWATCGRGRRQQQQQQQQQTHAQPSQGSTATGRRSRPHVT--------H------RGTPLSMLISNGVRISNNRL---AVIIIGIITLIL--GII------ A_aegypti_AAEL011222-PA --------------------------------MKQIMNVFGNRYNSVRTNDCDNGRFESFAANRRNLTRQFSIVDSFFHQRKEGERTRYPKYNF---FLMAVGLILICL--GVM------ C_intestinalis_ENSCINP00000010908 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C03F11.3 ---------------------------------------------------------------------------------MASRSCICQVSAG---IIFLIGAALLVA--GLV------ A_aegypti_AAEL005979-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0110565 MKEFSKMFARRYSSVSRDVEASNQRQSAVTPGSGLSTDADPAVSCAAQVALQRIQRRKSLKANRS--MNPIDILSSFFNEPIQGKRNRVPTRLF---ILLVIGFLAIIT--STL------ D_melanogaster_FBpp0080584 ---------------------------------------------------------------------------------MCCSCCGVTQQKA---WVFGLGTFFAVS--GLL------ D_melanogaster_FBpp0079173 --------------------------------------------------------------------------------------MIGKQRIW---QTSVLGLLLASF--SLF------ D_melanogaster_FBpp0083430 ----------------------------------------------------------------------------------------MQVPRV---KLLMGSGAMFVF--AII------ C_elegans_Y76A2B.6 ---------------------------------------------------------------MPSSNNSSNGASSSSPIASKYSSGRMRRMSC---CQLVISAVLIGL--GSFLLFGSL D_melanogaster_FBpp0082805 -------------------------------------------------------------------------------MKLFTNKNQRNAKLL---RSAALGMTLLFF--GSL------ A_aegypti_AAEL002741-PA -----------------------------------------------------------------------------------------------IVRLGFLGMLFIVL--GCV------ C_elegans_Y49E10.20.1 ------------------------------------------------------------------------------------MLKKAPCLFG---SAIILGLLLAAA--GVL------ A_aegypti_AAEL008370-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005374-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080585 ---------------------------------------------------------------------------------MRCGCCSVRQQKI---WVFSMGGLILAI--GIF------ A_gambiae_AGAP004643-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007748-PA M----------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP002451-PA ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008199 ---------------------------------------------------MGRCCFYTA-------------------------------------GTLSLLLLVTSV--TLL------ A_gambiae_AGAP010132-PA -------------------------------------------------------------------------------MCCCSKRYSNNAKKL---WAFGGVVAIFAA--AAF------ A_aegypti_AAEL009420-PA ---------------------------------------------------------------------------------MCCCNCSNTAKKV---WSFMGVVLIFGL--AAF------ A_aegypti_AAEL000234-PA --------------------------------------------------------------------MNIMDAKLCEKKKKRHIKLCDLIAIS---SISCLAVIFFTV--GFF------ C_intestinalis_ENSCINP00000027668 -----------------------------------------------------------------------------------MGCCNKKCGLI---ATVIVGGILVIL--GGI------ A_gambiae_AGAP004847-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012849-PA -------------------------------------------------------------------------------M---------------------------------------- C_elegans_F11C1.3 -----------------------------------------------------------------------------------------MRLFV---AIILAAVILLVFALGIF------ D_melanogaster_FBpp0072310 ----------------------------------------------------------------------------------------MKSVQW---VKILLCLILACV--NVF------ C_elegans_F07A5.3 ----------------------------------------------------------------------------------MGFRIRINKLDV---FLVVIAIVFIVF--GIV------ C_elegans_R07B1.3 -------------------------------------------------------------------------------------MVSIKRYEI---ISFVIAAFFFLS--GLS------ A_gambiae_AGAP000016-PA ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 -LM-PVGDMLIEKTIKREVVL----EE-GT----TAFKNW-VK---TGTTVYRQFWIFDVQNPDDVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPE R_norvegicus_ENSRNOP00000008319 -LM-PVGDLLIEKTIKREVVL----EE-GT----IAFKNW-VK---TGTTVYRQFWIFDVQNPEEVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPK R_norvegicus_ENSRNOP00000058398 -LM-PVGDLLIEKTIKREVVL----EE-GT----IAFKNW-VK---TGTTVYRQFWIFDVQNPEEVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPK C_familiaris_ENSCAFP00000009599 -LM-PVGDMLIEKTIKKEVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNAQEVVANS---SKIKVKQRGPYTY--R---VRY--------------LAKENITHDTE P_pygmaeus_ENSPPYP00000020018 -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDPE P_troglodytes_ENSPTRP00000033093 -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDPE B_taurus_ENSBTAP00000023750 -LM-PVGDMLIEKTIKKEVVL----EE-GT----IAFKNW-VK---TGTDVYRQFWIFDVQNPDEVTVNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPE H_sapiens_ENSP00000308165 -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDAE E_caballus_ENSECAP00000013084 -LM-PVGDMIIQKTIKKEVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNPQEVAVNS---SKIKLMQRGPYTY--R---VRY--------------LAKENITHDSE M_domestica_ENSMODP00000021313 -LM-PVGDMIVQNTIKKECVI----ED-GT----IAYKNW-VK---TGTEVYRQFWIFDVQNPEEVMINS---TKLKVKQRGPYTY--R---VRY--------------LAKENLTQNS- B_taurus_ENSBTAP00000018902 -LM-PVGDMLIEKTIKKESVL----EE-GT----IAFKNW-VK---AGANVYRQFWIFDVQNPEEVAVNS---SKIKVKQRGPYTY--R---VRY--------------LAKDIISQDSK O_anatinus_ENSOANP00000005521 -LM-PVGDMIIQKTIKKQGII----EE-GT----VAYKSW-EK---TGTDVYRQFWIFDVQNPDEVRVNN---SKIVVKQKGPYTY--R---VRF--------------LPKENITKNS- G_gallus_ENSGALP00000013734 -LI-PVGDNLINRAIKKDAVI----SN-GT----IAYDNW-LV---PGSSVYRQFWIFNVENPSDVLNFG---ARPKLEQRGPYTY--R---VRY--------------LPKENITENP- O_cuniculus_ENSOCUP00000002156 -LM-PVGDILIEKTIKKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXX--X---VRY--------------LAKENVTQDPE T_guttata_ENSTGUP00000002704 -LI-PVGDNLIGKAVKKEAVI----VN-GT----TAFKNW-LV---PGSSVYREFWIFHVLNPSEVMEEG---AHPKLEQRGPYTY--R---VRY--------------LPKENVTEGE- A_carolinensis_ENSACAP00000015615 -LI-PVGNYFVEETVKKETII----EN-GT----IAFENW-VV---PGSPVFRQFWIFDVQNPEDVMKNG---SQPIVKQKGPYTY--R---IRY--------------LAKENITHHP- X_tropicalis_ENSXETP00000017231 -LF-PVGDMIINKEISTEAVI----EE-GT----IAYENW-IE---AGSPVYRHFWIYHVTNPDEII-NG---GKPILQQKGPYTY--RIQSVRY--------------LPKENITQLE- T_rubripes_ENSTRUP00000041076 -LI-PVGRNIIKGTVEKEAVL----EP-GT----TAHDNW-VS---AGATVYRQFWIFDVKNPQEIVNDG---ATPVVVEKGPYTY--K---TRY--------------LPRDNITYG-- D_rerio_ENSDARP00000050752 -LI-PVGDMIIKNTVHKETVL----EN-GT----LAFDTW-TS---VDIAMYRQFWIFNVENPDKVLSEG---SKPVLVQKGPYTY--R---VRY--------------IPKTNITFND- O_latipes_ENSORLP00000020106 -LI-PVGDMIIEETVKKEAVI----EP-GT----IAYDNW-AA---AGVKVYRQFWFFDVQNPSEV-EQG---AKPVLVEKGPYTY--G---TRF--------------LAKENVTFLL- T_nigroviridis_ENSTNIP00000014345 -LI-PVGKTVIRSTVEKEAVL----EP-GT----TAYDNW-VS---ADAPVYRQFWFFHVKNPEEVVKNG---TTPVVEERGPYTY--R---TRY--------------LPKENVTYGN- G_aculeatus_ENSGACP00000026365 -LL-PVGNSIIRETVEKEAVI----EN-GT----TAYDNW-VA---GGVVVYRQFWLFDVQNAEEVVRSG---ATPVVLEKGPYTY--K---TRY--------------LAKENITFNS- G_gorilla_ENSGGOP00000005986 -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDVQNPQEVMMNS---SNIQVKQRGPYTY--X---XXX--------------XXXXXXXXXXX X_tropicalis_ENSXETP00000017237 -LF-PVNNILNHEAVTKTSVI----EE-GT----AAFDNW-VL---PRSPVYRSFWIYHVRNPNDII-NG---GKPELQQKGPYTY--L---VRR--------------IPKLGITQHE- T_guttata_ENSTGUP00000001744 -VA-HVFQTVVDLQVKQGTVL----KN-GT----ETFEAW-ED---PPPPVYMQFYFFNVTNPLEVLQG----ATPLVEEIGPYTY--R----EY--------------RPRVHVQFLD- X_tropicalis_ENSXETP00000052043 -LT-HTFMDIVEGQVKQAIVL----KN-ES----EVFEDW-AN---PPPPVYMQFYFFNVTNPLEVLSG----EKPFVDEIGPYTY-------EY--------------RPRENITFSV- M_mulatta_ENSMMUP00000027514 -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNVTNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANVQFGD- G_gallus_ENSGALP00000018715 -VA-HVFQTVVDLQVKQGTVL----KN-GT----ETFEAW-ED---PPPPVYMQFYFFNVTNPLEVLQG----ATPLVEEKGPYTY--R----EY--------------RPRVHVQFLD- G_aculeatus_ENSGACP00000022821 -LS-NVFPLLTQSLVEKEVVL----KN-GT----EAFEAW-KN---PPAPIYMQFYFFNLTNPLEVLDG----DRPAVVEIGPYTY--R----EY--------------RPMEQVDFQD- H_sapiens_ENSP00000264896 -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNVTNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- O_latipes_ENSORLP00000012225 -LS-GVFPHLLQSFVETEVVL----KN-GT----DAFEAW-AD---PPAPIYMQFYFFNLTNPEEVLKG----ERPAVVELGPYTY--R----EY--------------RPMEEVAFLE- O_anatinus_ENSOANP00000014317 ----------------QNVVL----KN-GT----DAFESW-EK---PPPPVYMQFYFFNVTNPSEALRG----ETPEVEEVGPYTY--R----EH--------------RPRENIRFWD- P_troglodytes_ENSPTRP00000027814 -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNVTNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- M_domestica_ENSMODP00000037525 -------------SLPQNIVL----KN-GT----EAFDSW-EN---PPPPVYMQFYFFNVTNPDEILQG----EDPRVEEVGPYTY--S----EL--------------RTTALVEVGE- P_pygmaeus_ENSPPYP00000016592 -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNVTNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- T_rubripes_ENSTRUP00000042953 -VA-QVFQTMIHERLKKEFTL----TE-AS----QVFESW-KN---PPPPVYMEYYFFNVTNPKEFLAG----GKAAVQQIGPYTYRHR----EY--------------RPRENISFLE- R_norvegicus_ENSRNOP00000003052 -VA-RVFQKAVDQTIEKNMVL----QN-GT----KVFDSW-EK---PPLPVYIQFYFFNVTNPEEILQG----EIPLLEEVGPYTY--R----EL--------------RNKANVQFGE- O_latipes_ENSORLP00000001610 -LV-FVGPIIIDDQVEKNTMI----DPKND----MSYTMW-KD---LPVPFFMSVYFFNVLNPEEVL-KG---EKPMVEQRGPYVY--R----KR--------------CQKENITFHP- D_rerio_ENSDARP00000023056 -LA-QVFQTMIQERIKKEITL----AE-NS----RVLDGW-IN---PPPPVYMQYFFFNVTNPDEFLAGK---EKAKVTQMGPYTY--R----EY--------------RPRENVTYLE- P_troglodytes_ENSPTRP00000009553 -MI-VMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDVMNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- H_sapiens_ENSP00000261693 -MI-VMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDVMNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- M_musculus_ENSMUSP00000031377 -VA-RVFQKAVDQTIEKNMVL----QN-GT----KVFNSW-EK---PPLPVYIQFYFFNVTNPEEILQG----EIPLLEEVGPYTY--R----EL--------------RNKANIQFGE- O_latipes_ENSORLP00000008151 -VG-RVFHTLMENRLKKEIVL----VE-GS----RVFESW-KN---PPPPVFMEFFFFNITNAEDCLNG----AKPKVTQIGPYTY--R----EY--------------RYKDNVTMVE- T_nigroviridis_ENSTNIP00000018658 -GA-QFFQTLIHERLKKEITL----TE-AS----QVFESW-KN---PPPPVYMEYYFFNVTNPEEFLAG----GKAAVQQIGPYTYRNR----EY--------------RPRENISFLE- G_gallus_ENSGALP00000004761 -LL-LAGPAIVKEQVLKNVRI----DP-SS----ISFNMW-RD---IPVPFYLTVNLFEVQNPQEVL-QG---AKPKVNQRGPYVY--R----EF--------------KYKTNITFHD- T_rubripes_ENSTRUP00000019814 -LS-KVFPRFVHSMVEKEVVL----KN-DT----DAFEAW-EN---PPAHIYMQFYFFNVTNPLEVLSG----ERPAVVEVGPYTY--R----EY--------------RPMEEVAFQE- B_taurus_ENSBTAP00000014549 -VA-RVFQKAVDQTIEKNIVL----RN-GS----ETFDSW-KK---PPLPVYTQFYFFNVTNPEEILNG----ETPRLEEVGPYTY--R----EL--------------RNKDDIQFGD- T_nigroviridis_ENSTNIP00000016587 -LA-FVGPIIIDDQIVKNTVI----DPKNE----MSYTMW-KD---VPVPFFMSVYFFHVLNSKEIL-KG---EKPMVEQRGPYVY--R----KR--------------IQKENITFHP- E_caballus_ENSECAP00000022283 -----------------NVVL----RN-GS----ETFNSW-KN---PPLPVYSQFYFFNVTNPEEILRG----ETPRLEEVGPYTY--R----EL--------------RNKADIEFGD- O_anatinus_ENSOANP00000002110 -MV-FVVPILIKQQIHKNVRI----DP-NS----LSYNMW-KV---IPVPFYLSVHFFEVLNPNQIL-KG---EKPSVRERGPYVY--R----EF--------------RHKDNITFND- T_nigroviridis_ENSTNIP00000002999 -LS-GVFPRFLQSRVKKEVVL----KN-AT----DAFEAW-ED---PPAQIYMQFYFFNVTNPLEVLDG----ERPAVVEVGPYTY--R----EY--------------RPMEEVTFQA- T_rubripes_ENSTRUP00000047691 -LT-FVGPLIIDDQVVKNTVI----DPKNE----MSYTMW-RD---VPVPFFMSVYFFHVLNPKEIL-AG---EKPMVEQRGPYVY--R----KR--------------IQKDNITFHP- T_nigroviridis_ENSTNIP00000010349 -VS-QVFRTLMHNRLKKEIVL----VE-GS----RVFEYW--N---PAPSVYME-FFFNVTNLDQVLAG----GKPEVTQVGPYTY--R----EY--------------RYKENVSMVQ- T_guttata_ENSTGUP00000005161 --------------AFQNVRI----DP-SS----ISFQMW-KD---IPVPFYLMVYFFEVLNPKQVL-RG---EKPVLSQRGPYVY--R----EY--------------RFKTNITFYD- M_domestica_ENSMODP00000019581 -MI-FVVPEMIRNQVLQNVRI----NP-SS----LSFEMW-KE---IPIPFYLSVHLFNVLNPDEVL-KG---EKPRVEERGPYVY--R----EY--------------RQKQNITFHD- A_carolinensis_ENSACAP00000014578 -MI-VLVPRIVREQVVKNVRL----EP-NG----MAFELW-KD---IPVPFYFSVYLFEVLNPDDIL-RG---EKPVVNQRGPYVY--R----EY--------------RVKENITFHE- C_familiaris_ENSCAFP00000012634 -----------------NIVL----RN-GS----ETFDSW-KK---PPLPVYAQFYFFNVTNPEEILRG----EIPRLEEVGPYTY--R----EL--------------RDKADIQFGD- B_taurus_ENSBTAP00000018959 -MI-VMVPSIIKQQVLKNVRI----DP-NS----LSFNMW-KE---IPVPFYLSVYFFNIVNPEGII-QG---QKPQVQEHGPYVY--R----EF--------------RHKSNITFNN- T_rubripes_ENSTRUP00000036580 -VS-QVFRTLMHNRLKKEIVL----VE-GS----RVFPSW-KN---PPPPVYMEFFFFNITNEEQILKG----GKPEVTQVGPYTY--R----EY--------------RYKDNVSMVQ- G_aculeatus_ENSGACP00000021517 -VA-QVFRTFMHNRLKKEIVL----VE-GS----RVFESW-KS---PPPPVYMEYFFFNMTNVDAFLAG----AKPQVTQVGPYTY--R----EY--------------RYKDNVSMLD- R_norvegicus_ENSRNOP00000001301 -MI-LMVPSLIKQQVLKNVRI----DP-SS----LSFGMW-KE---IPVPFYLSVYFFEVVNPSEVL-NG---QKPVVRERGPYVY--R----EF--------------RQKVNITFND- P_pygmaeus_ENSPPYP00000005810 -------------QVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDVINPNEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKTNITFNN- M_musculus_ENSMUSP00000083242 -MI-LMVPSLIKQQVLKNVRI----DP-SS----LSFGMW-KE---IPVPFYLSVYFFEVVNPNEVL-NG---QKPVVRERGPYVY--R----EF--------------RQKVNITFND- D_rerio_ENSDARP00000076810 ----------------QEITL----TE-GS----KVFATW-KN---PPPPVYMEFFFFNVTNPEAFLKGE---AKARLSEMGPYTY--R----EY--------------RPKHNVSFVD- A_carolinensis_ENSACAP00000012360 -AA-RVLQKVVELQVKQQMVL----KN-GT----EVFEMW-EE---SPPPVYMQFYFFNLTNPLEVLQG----EKPLVQEIGPYTY--R----ET--------------RPRVAVHILD- X_tropicalis_ENSXETP00000002583 -LV-FLVPVIMDEQVEKNVRI----DPSSG----FAYEMW-RD---LPVPFYMSIYIFEVVNHKEVL-LG---EKPQLQERGPYVY--R----EY--------------KKKQNITFNE- C_familiaris_ENSCAFP00000010357 GPV-CFAPP------LQNVRI----DP-NS----LSFNMW-KE---IPVPFYLSVYFFDVVNPDAVL-LG---QKPQVRERGPYVY--R----EF--------------RHKSNITFND- C_intestinalis_ENSCINP00000025688 ----DIADKFINMEMNKQLVL----SL-DS----PAYPQW-MN---PKPPIYMEYWLFNITNPEEVS-NG---GKPNVTEIGPFRY--R----LF--------------QPRIDVAFYT- T_guttata_ENSTGUP00000016695 ----------------QEAVI----VN-GT----TAFKNW-LV---PGSSVYREFWIFHVLNPSEVMEEG---AHPKLEQRGPYTY--R---RK-----------------DQLICDTV- O_latipes_ENSORLP00000000458 -VA-QVFQTMIHERLKQ--VG----PR-AC----AGREAV-SP---SPQQGHSTFRWLSINLTPRFLSWE---EEARLASSSSLPA--F----NY--------------KPRENVTFLE- A_gambiae_AGAP004846-PB -VT-FGFTAFIRTIIDHQVAL----RV-GG----QSFGWW-SR---PPVEPIIRIFVYNVTNADEFLNNG---TKPILDELGPYVY--V----QT--------------WEKVNIKENP- M_mulatta_ENSMMUP00000038414 -MI-VMVPSLIKQQVLKVAQV----DP-SI----LRIAAW-QV---VPISFFFFFFFFFETESCSVS-VG---WSAPTRRHSPYAR--E----EF--------------RHKTNITFNN- D_melanogaster_FBpp0072308 -VA-CEFTVLIDAVVDRMVAL----RP-GA----KTFGWW-AK---PPVEPRISLYIYNVTNADDFLSNG---SKAIVDEVGPYVY--S----ET--------------WEKVNIVEND- A_aegypti_AAEL000256-PA -VT-FGFTTLVRAVINHQVAL----RK-GG----QSFGWW-SK---PPVEPIIRIFVYNVTNADEFLNNG---TKPVLDELGPYVY--V----QT--------------WEKVNIVENP- E_caballus_ENSECAP00000021856 ----------------QNVRI----DP-SS----LSFDMW-KQ---IPVPFYLSVYFFHVLNPNEVL-QG---GKPQVQERGPYVY--R----EF--------------RHKSNITFKD- D_melanogaster_FBpp0110185 -CGWILFPNMVHKKVEQSVVI----QD-GS----EQFKRF-VN---LPQPLNFKVYIFNVTNSDRIQQG----AIPIVEEIGPYVY--K----QF--------------RQKKVKHFSRD D_rerio_ENSDARP00000089887 -----------------MWRS----IP-KT----ISPTPC-GD---IPVPFFMSVYFFHIVNPDEIL-KG---ERPMVIQRGPYVY--R----EN--------------RWKDNITFHE- A_gambiae_AGAP010133-PA -LG-VLWPSLSEQVLHNKLVI----KN-GS----SNYDNW-IR---TPIPMYLEVYFFNWTNPDEVKTKNG--TKPHFVEMGPYTF--S----EV--------------HERVNLVWNA- D_melanogaster_FBpp0079088 -CG-MFWVDLFDWIMHKEMAL----AP-DT----RVYENW-KS---PPIDLSLDIYLYNWTNPEDFGNLS---TKPILEQVGPYRF--I----ER--------------PDKVDIHWHPE A_gambiae_AGAP004845-PA -FI-MWFTNMYNNSLLEKLIL----SE-NS----TAAEWW-EN---PPVYPLLKVHVFNYTNTEDFFAGKA--TKLQVEDLGPYVY--K----ET--------------ANKVDITHNG- A_gambiae_AGAP005716-PA -LGWVVFPRAVHEKVIEATEL----RQ-GT----DQYKRW-EA---LPQPLDFKVYIFNVTNPYEVMQG----RRPKVVEVGPYVY--F----QY--------------RQKDNVRFSRD A_aegypti_AAEL000227-PA -FV-MWFTDIYDNSLLENLKL----SH-KS----TAAEWW-EK---PPVNPLLKVHIFNYTNMDDFFSGKA--DKLKVVDLGPYVY--H----ET--------------AEKVNVSYHG- A_gambiae_AGAP003373-PA -----------------ELKL----RP-GS----RSYDSW-VS---PPFPLAMDVYFFNWTNPEDITNHS---TKPILEELGPYRF--I----EH--------------PTKVDIEWHDA D_rerio_ENSDARP00000071723 --------------------------------------------------------------------------------VGVSSF--R----EY--------------RPMEEVKFMD- D_melanogaster_FBpp0077748 -IV-VFWPGIADNLVEDGLTL----KP-GT----DAYESW-LE---APIPIYLSFYMFNWTNPEDIRNPD---IKPNFVEMGPYTF--L----EK--------------HKKENYTFYD- O_cuniculus_ENSOCUP00000002939 -VA-RVFQKAVDQAVQKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXX--X----EL--------------RNKANIQFGD- C_intestinalis_ENSCINP00000011713 ---------------------------------------------------YMEYWLFNITNPEEVS-NG---GKPDVTEIGPFRY--R----LF--------------QPRIDVAFYT- A_gambiae_AGAP002738-PA ----IHILDPYLLIFKWKLIF----QE-GS----EIFNLW-RT---PPVDLYIKIYLFNVTNAEDFMAGRA--EKMQIEEVGPYVY--R----EL--------------MSHDNITFND- A_aegypti_AAEL009423-PA -LG-TLWPSMSSKLLRDKLVI----KN-GS----VNYQNW-IR---TPIPMYLEVYLFNWTNPQDLDKFPT--VKPHFEEMGPYVF--H----EV--------------HDRINLEWNE- D_melanogaster_FBpp0072303 -FV-MWFTEYYNNTILENLIL----AE-NS----DTANSW-LNPD-PKYDTLLKAHIFHYPNIDDYLAGRA--DKIKVVDVGPLTY--Q----EH--------------TVKDEVSFNK- A_gambiae_AGAP008179-PA -LG-LVWPALIWQIAKREFVL----EP-GT----EVYKNW-IE---PPIDTYLELYLWNWTNADAYLT-----EKPHLEQLGPYTF--R----EV--------------HERVNLKWND- A_gambiae_AGAP005725-PA -----------------NLRL----WN-GT----ISFHYW-QR---PGVTRLTKVYIFNVTNPEGFL-AG---EKPKLVEVGPFVY--R----ED--------------MEKVNIKFHD- G_aculeatus_ENSGACP00000018249 -VA-QVFQTMIHSRLKKEITL----TE-NS--------QW-KDERYPPPPVYMEYYFSNVTNPELFLAG----GKAAVKQIGPYTY--R----EY--------------RPRVNITFLE- A_aegypti_AAEL009432-PA -FG-IAWPFIIRGEIEKQFAF----AP-GK----EVYENW-LN---PPIDSFLELYLWNWTNAEDYRS-----EKPHLEQLGPYTF--R----EK--------------MERIGLVWNDD G_gorilla_ENSGGOP00000006367 -MI-MMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDVMNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- D_melanogaster_FBpp0079175 -LF-RNWIDMFTRMRGQEMAL----SP-NS----RSFEGW-KV---SPLPLDFDIYLFNWTNPDDFYVGSN--KKPHFEQLGPYRF--R----EK--------------PDKVDIEWHNH D_melanogaster_FBpp0112038 ----LSSMPWLDYFILKNLRL----WN-DT----LSYHYW-QR---PGVIRLTKLYIYNVTNPDGFL-RG---EKPHLQEVGPFVY--R----ED--------------MQKVNVKFHEN A_aegypti_AAEL011222-PA ----SHMCNPYMLIFKWKLIF----EN-GG----EIFELW-RT---PPVDLYIKIFLFNVTNAEQYLEGTA--EKMVFDEVGPYVY--R----EL--------------LSHENITFYD- C_intestinalis_ENSCINP00000010908 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C03F11.3 -IVLNVFPNIVNNQINDSKVL----GLNADGTLNSFTDSW-VN---SKYISTMQYWVYDYTNTIGIMNRA---IYPDVREKGPYAF--D----EI--------------LTMDKLNFSEN A_aegypti_AAEL005979-PA ---------------MKNLRL----WN-GT----ISFHYW-QR---PGVTRLTKVYIFNVTNPEGFL-AG---EKPKLVEVGPFVY--R----ED--------------MEKVNIKFHD- D_melanogaster_FBpp0110565 ----IKVLEPYDLIFKWKLIM----TE-GG----EIFNLW-AQ---PPVDLYIKIYLFNITNANAFLAGR---EQLRVEQVGPYVY--K----EI--------------MTHENVTFNS- D_melanogaster_FBpp0080584 -AI-ICWPGFIDSGIMKALPL----TP-TS----KTFEKW-EE---LPIPVYVYMYLWNWTNAADVQANG---VKPIFAQLGPYVY--R----EE--------------RKKMDLEWHD- D_melanogaster_FBpp0079173 -SV-LYMEQIERWMLEWFMVL----RP-GT----MISSLW-QS---PAMDINVDLYIFNWTNSEKFSDPT---VKPRFEELGPYRF--T----ER--------------MQKVNVEWHDE D_melanogaster_FBpp0083430 -YGWVIFPKILKFMISKQVTL----KP-GS----DVRELW-SN---TPFPLHFYIYVFNVTNPDEVSEG----AKPRLQEVGPFVF--D----EW--------------KDKYDLEDDVV C_elegans_Y76A2B.6 ITHTVVVPKVVKSSIEENSRL----VN-GS----IMWEKW-AM---PEYKIRFNMYVYSTKNPDEFMNG----AIPEVTGSGPYVF--D----KK--------------MENRVVSAE-- D_melanogaster_FBpp0082805 ----VIISDPLQSILDTQLSL----KP-GT----LLHRLW-LL---PPLDVYINVYMFNYTNVDEFTSGRA--SKLQLQEVGPYVY--K----EV--------------LSNHNVTYNES A_aegypti_AAEL002741-PA ----IVVLNPTDLVVNNMLSM----NE-GS----YLHRLW-KK---PPLEVFISIYVFNVTNADAFMRGK---EKMKVEELGPYVY--Q----EY--------------LENHNSTFNA- C_elegans_Y49E10.20.1 LLIGIPIDRIVNRQVIDQDFLGYTRDENGTEVPNAMTKSW-LK---PLYAMQLNIWMFNVTNVDGILKRH---EKPNLHEIGPFVF--D----EV--------------QEKVYHRFADN A_aegypti_AAEL008370-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005374-PA ----------MLIKNRKNLML----KP-GT----QMRGMF-EK---IPFPLDFKLYLFHVTNPDVVMKG----GKPRVREIGPYFF--E----EW--------------KEKYDTVDNEE D_melanogaster_FBpp0080585 -LA-SAWPAVSRQWIRSLLPL----AP-NS----FIYNRW-VT---TPTPVYSTVFLFNWTNPGDLNTEG---VKPHFEQLGPYTF--S----DF--------------KVKEDLEWNQP A_gambiae_AGAP004643-PA -----------------KLSM----YE-GS----YLNRLW-KK---PPLEVFISIYVFNVTNPVAFMRGE---ERLRVQEIGPYVY--Q----EF--------------LEHRNSTFNQ- A_aegypti_AAEL007748-PA ----SLDKKFWIKYTKIEKIL----SP-TS----RAFKLW-RR---PPVPVQWRITLFNWTNAEAFLANKV--SKPTFSEVGPFLY--S----EI--------------LEKVDARFNTK A_gambiae_AGAP002451-PA ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008199 -VA-RVFQKAVDQSIEKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXX--X----EL--------------RNKANIQFGD- A_gambiae_AGAP010132-PA -FG-FGLPAIIDAVALTEFRV----KE-GA----RVYENF-FD---GEVPIFFDIYLFHWTNPEQIRDPN---VRPNFVQMGPYVF--S----ER--------------HERGMVSFND- A_aegypti_AAEL009420-PA -FG-FGFPAIVDSVARQEFVM----KP-GT----EVYENW-MN---SPVPMFMDIYFWDWTNPNEITNPA---VRPNFVQKGPYVF--K----EV--------------HERINASFNN- A_aegypti_AAEL000234-PA ----IQRNDLTKLILDDRLEM----RQ-FT----PHFKWWQNT---SDVLVTCKVYVFSVTNAERWMNNLD--EQLHFEEIGPIVY--R----ET--------------LDHHNVVFHPE C_intestinalis_ENSCINP00000027668 -IN-VVFEDLFNQILLQESVI----AV-GT----LMYDNW-IE---VATPTYLSYYLYNMTNGDEFLAPRKPYVKPNLQEIGPYVF--R----EY--------------LSKDTVHFLDD A_gambiae_AGAP004847-PA --------------------------------------------------VTCRIFIFNVTNSERWLGGLD--DQLKMQEVVPIVY--R----EI--------------LEHDNVTFHEH A_gambiae_AGAP012849-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_F11C1.3 -LLIPFPIAIFQSIVDSQVYL----QQKSDGQLPTGTFYW-SK---IPAVQIWTFHLFNVTNPDEVLYYG---ATPNMLEIGPYTY--T----ET--------------EFKDFTQFRDN D_melanogaster_FBpp0072310 LFVVSWGVDYRILVAREHIRF----RQ-EM----PTMDSW-IN---SPFG-KLKNYVFNVTNAEEFRSGRD--SRLKVKEIGPIVY--R----IV--------------GFNDILDRNET C_elegans_F07A5.3 -TW-AAFSSIYSTLVIKNLQL----TENSDTSLGYSAFQY-TS---PQVDNIMKFYFFNVTNPDEVKYYS---AAPNLVEIGPFSV--M----ES--------------EQKKYLEFSDD C_elegans_R07B1.3 -MW-IAFWPIFNSELRSNYKL----GANDDGSLHYAAFLY-AN---PPMKNVMKFNLFNVTNPDEVKYLG---AKPELIEVGGYAF--L----ES--------------EQKKYYEFSSD A_gambiae_AGAP000016-PA -------------STSKEKSL----LP-GS----TLYKEW-RR---PTERPSWQFYVYNWSNAQAILEHQA--SSASFQEIGPFQY--E----EFNYHSPYAARPRTEVAEVVDVKYHQA 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 D--HT-VSFVQPNG--AIFEPSLSVGT-E--DDNFTVLNLAV------------------A------AA--------PHIYQN-------SFVQVVL--NSLIKKS---KS-SMFQTRSL R_norvegicus_ENSRNOP00000008319 D--ST-VSFVQPNG--AIFEPSLSVGT-E--NDNFTVLNLAV------------------A------AA--------PHIYTN-------SFVQGVL--NSLIKKS---KS-SMFQTRSL R_norvegicus_ENSRNOP00000058398 D--ST-VSFVQPNG--AIFEPSLSVGT-E--NDNFTVPNLAV------------------A------AA--------PHIYQN-------SFIQGVL--NNLIKKS---KS-SMFQTRSL C_familiaris_ENSCAFP00000009599 N--HL-VSFVQPNG--AIFEPSLSVGT-E--DDTMTVLNLAV------------------A------AA--------PHLYPN-------AFVQVVL--NSLIKKS---KS-SMFQNRTV P_pygmaeus_ENSPPYP00000020018 D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------A------AA--------SHIYQN-------PFVQVVL--NSLINKS---KS-SMFQVRTL P_troglodytes_ENSPTRP00000033093 D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------A------AA--------SHIYQN-------QFVQMVL--NSLINKS---KS-SMFQVRTL B_taurus_ENSBTAP00000023750 T--HT-VSFLQPNG--AIFEPSLSVGT-E--DDTFTILNLAV------------------A------AA--------PQLYPN-------TFMQGIL--NSFIKKS---KS-SMFQNRTL H_sapiens_ENSP00000308165 D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------A------AA--------SHIYQN-------QFVQMIL--NSLINKS---KS-SMFQVRTL E_caballus_ENSECAP00000013084 N--HT-VSFVQPHG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------A------AA--------AHLYEN-------PFVQVVL--NSLIKKS---KS-SMFQTRTL M_domestica_ENSMODP00000021313 D--NT-ISFVQPNG--AIFERRLSVGT-E--NDSFTVLNLAV------------------A------AA--------PILYPN-------SFVQMVL--NSFIKKS---HS-SMFQVRTL B_taurus_ENSBTAP00000018902 T--HT-VSFQRPKG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------A------AT--------PHLYPS-------TFVQIIL--NVFIKNS---NS-FMFQKRTL O_anatinus_ENSOANP00000005521 D--NT-ISFMQPNA--AIFEPSMSVGS-E--YDTCTVVNLAV------------------V------AV--------PVLFPN-------AFVQRLL--NSYIKKS---KS-SLFQIRTV G_gallus_ENSGALP00000013734 N--GT-ISYMLPNA--ARFEPDMSVGT-E--NDTITCLNLAV------------------V------AA--------PALYKN-------NFIQLLL--NTWIKSS---KS-NMLQNRTV O_cuniculus_ENSOCUP00000002156 D--HT-VSFVQPNG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------A------AA--------PHIYQN-------TFVQVLL--NSLIKKS---KS-SMFQTRTL T_guttata_ENSTGUP00000002704 N--GT-ITYMMPNA--ANFEPAMSVGT-E--NDTLTVLNLAV------------------V------AV--------PSVYPS-------TLMQSVI--NTWVKSS---KA-AILQNRTV A_carolinensis_ENSACAP00000015615 D--ST-VSYFQPNI--AQFEPDMSVGP-E--NDTFTMVNLAV------------------V------AA--------PALYQT-------GFMQALL--NVFIKSS---KS-EFLQTRSV X_tropicalis_ENSXETP00000017231 N--NT-VSYWQPNG--AIFQREGSYGP-E--EDTYTVLNLAV------------------A------AA--------PAMFPA---------LQGLL--NAIIKSS---NS-SLFQVRSV T_rubripes_ENSTRUP00000041076 D--IT-VSFVLPAG--AIFIPSMSVGL-E--EDSVTCLNLVV------------------AVSVAWRSR--------TTMAHF--------VVVVVV--FFAITTI---SKLSLFQHRTV D_rerio_ENSDARP00000050752 N--NT-VSFVLPAG--ATFEPSMSVGS-E--EDVFTSLNLAV------------------A------GV--------YRLIG-----------PKLA--DWLIRSS---GS-SLFQNRTV O_latipes_ENSORLP00000020106 N--DT-VSFLLPQG--AIFEPSMSVGP-E--ADNISCLNLGV------------------AIFKKQ-GA--------YSLLP-----------HNVL--ELLISAN---KA-SLFQNRTV T_nigroviridis_ENSTNIP00000014345 D--ST-VSFMLPLG--AIFEPSLSVGP-E--DDTVTCLNLVV------------------A------GA--------YTLVPE--------YLHWVL--DLAIKGT---NS-SLFQRRSV G_aculeatus_ENSGACP00000026365 N--LT-ASFVLPVG--AIFDPSMSVGP-E--EDTVTSLNLAV------------------AVS----EP--------YSLVP--------TELHGVL--DKLITTS---KS-SLFQLRTV G_gorilla_ENSGGOP00000005986 X--XX-XXXXXXXX--XXXXXXXXXXX-X--XXXXXXXXXXX------------------X------XX--------XXXXXX-------XXXXXXX--XXXXXXX---XX-XXXXXXXX X_tropicalis_ENSXETP00000017237 N--FT-MSYLQYND--AIFQRHMSVGS-E--EDTHTVLNVAV------------------A------ST--------PDMFPD---------YHEIL--NTAITNS---SS-SLFQVRTV T_guttata_ENSTGUP00000001744 N--GTKVSALNPKT--YVFEPEKSVGDPE--VDLIRTVNIPA------------------V------TA--------MEWTRST-------PLQFAT--EVLLLLY---QE-SLFTVRSV X_tropicalis_ENSXETP00000052043 N--GTEVSAVTPKT--YVFEPEKSIGDPK--VDLIRTVNIPL------------------V------TI--------LEMTKDSS------LLRLFI--IAALKTY---KE-GMFVTRTV M_mulatta_ENSMMUP00000027514 N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV G_gallus_ENSGALP00000018715 N--GTKVSALNPKT--YVFEPEKSVGNPE--VDLIRTINVPA------------------V------TA--------MEWTRAT-------SLQFAT--EVLLLLY---QE-SLFTVRTV G_aculeatus_ENSGACP00000022821 N--GTKVAAVNTKT--YIFQPNMSRG-PE--SELIRTVNIPA------------------M------TV--------MEQFKDQP------LIANLI--AAYMRSA---DE-GLFSTHTV H_sapiens_ENSP00000264896 N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV O_latipes_ENSORLP00000012225 N--GTKVAAVNTKT--YIFQLNMSRG-PE--SDLIRTVNIPA------------------V------TV--------MEMFKDST------LEANLI--SAYMRSS---GE-GLFSTHTV O_anatinus_ENSOANP00000014317 N--GTKVSAINPKT--YIFERDLSVGDPA--VDLIRTVNIPA------------------V------TA--------MRWSQNR-------FLKEII--EGILKGF---QQ-SLFVTHSV P_troglodytes_ENSPTRP00000027814 N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------L------TV--------IEWSQVR-------FLREII--EAMLKAY---QQ-KLFVTHTV M_domestica_ENSMODP00000037525 G--GKEYDSCNQLTPDYVFQRDLSVGDPE--VDLIRTLNIPA------------------I------TA--------MEWTTNN-------VLKEIL--EGLLKTY---QQ-KLFVIHTA P_pygmaeus_ENSPPYP00000016592 N--GTTISAVSNKA--YVFERDQSVGDPK--MDLIRTLNIPV------------------L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV T_rubripes_ENSTRUP00000042953 N--GTKIYALNPKS--FVFVPEKSVGNPE--VDIVRTVNIPF------------------V------AV--------MNELSSYS-----FFLRTGI--SMYIKSL---GV-DLFLTRTV R_norvegicus_ENSRNOP00000003052 N--GTTISAVTNKA--YIFERNQSVGDPT--VDLIRTINIPL------------------L------TV--------VEMAQQP-------FLREII--EAMLKAY---QQ-TLFVTHTV O_latipes_ENSORLP00000001610 N--YT-VSYREYRT--YYFEPSMSVGN-E--SDLVTVPNMLV------------------L------SA--------AVMMENLP-----YALRLLI--SATFKTF---KE-GPFLTKTV D_rerio_ENSDARP00000023056 N--GTKIFATNPKS--FVFLRNMSAGDPE--VDRVTTVNIPM------------------I------AV--------MNELNSYS-----FFVRTAV--SMYMGSM---GM-GLFMNRTV P_troglodytes_ENSPTRP00000009553 N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV H_sapiens_ENSP00000261693 N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV M_musculus_ENSMUSP00000031377 N--GTTISAVTNKA--YVFERNQSVGDPN--VDLIRTINIPL------------------L------TV--------VDLAQLT-------LLRELI--EAMLKAY---QQ-KLFVIHTV O_latipes_ENSORLP00000008151 N--GTMVSAYTMKK--FVFLREKSVGDPA--VDNITTVNIPS------------------W------AV--------MEKMKDS-------WFRTVV--SMFMKTL---GS-GPFTSRTV T_nigroviridis_ENSTNIP00000018658 N--GTKIYALNPKS--FVFVPEKSAGNPE--VDIVRTVNIPY------------------V------AV--------MNELSSYA-----FLLRTLI--SMYIKSI---GV-EIFMTRTV G_gallus_ENSGALP00000004761 N--DT-VSYLEYRQ--LFFRPDLSNGT-E--DEYIVMPNILM------------------L------GA--------AVMMENLP-----SFVKLLL--SGALAGL---KQ-EAFINRTV T_rubripes_ENSTRUP00000019814 N--GTKVAAVNTKT--YIFQPEMSRG-PE--SDLIRTINIPA------------------V------TV--------MKKFQNV-------FLANLV--SAYMRTL---GV-GLFTTRTV B_taurus_ENSBTAP00000014549 N--GTTISAVSNKA--YVFERDKSVGDPK--IDLLRTLNIPA------------------L------TA--------MEWTQLP-------LLRDII--EALLKAY---RQ-KLFVTHTV T_nigroviridis_ENSTNIP00000016587 N--NT-VSYREYRS--YYFEPTMSVGN-E--SDVVTIPNMLV------------------L------GA--------SVMLEKLP-----IHVRMLI--SIGFKLC---KE-GPFLTKTV E_caballus_ENSECAP00000022283 N--G-TISAVSNKA--YVFERNQSVGDAK--TDLIRTLNIPA------------------L------TA--------MQLAQLH-------ILRELI--EALLKAY---QQ-KLFVTHTV O_anatinus_ENSOANP00000002110 N--DT-VSYLEYRS--FRFQPEMSQGS-E--DDYIVIPNILV------------------L------GS--------SIMMERMP-----LPLKWLM--SSSFNSF---NE-HAFMNRTV T_nigroviridis_ENSTNIP00000002999 N--GTRVAAVNTKT--YIFQPEMSRG-PE--SDPIRTLNIPA------------------V------TV--------MERFRKS-------WEAELI--SPYMRSL---GV-GLFTTRTV T_rubripes_ENSTRUP00000047691 N--ST-VSYKEYRS--YYFEPSMSVGN-E--SDVLTIPNMLV------------------L------GA--------AVMLESLS-----VPVRMII--SMAFKTF---DE-GPFLTKTV T_nigroviridis_ENSTNIP00000010349 N--GTRVSAHTIKS--FVFLPERSVGDPS--GDNITTVNIPV------------------W------AV--------MNKVSGN------LFKSSMV--SLWMNSL---KS-GLFTTRTV T_guttata_ENSTGUP00000005161 N--DT-VSYLEYRH--LFFQPDLSNGT-E--DEYIVVPNIMM------------------M------GA--------AVMMENKP-----GFMKFLL--SGALASL---KQ-EAFMNRTV M_domestica_ENSMODP00000019581 N--DT-VSFLEYRT--FEFQPHMSHGS-E--TDYIVMPNVLV------------------L------GS--------SVMMEHKP-----MSMKLLM--SLSFSMF---GQ-RAFLNRTV A_carolinensis_ENSACAP00000014578 N--DT-LSFLEYRQ--FHFKADMSNGS-E--SDYIVVPNMLV------------------M------GA--------AVMLEDLP-----FPVKLTI--SSTFALF---GQ-KAFMNLTV C_familiaris_ENSCAFP00000012634 N--GTTISAVSNKA--YVFERNQSVGDPK--TDLIRTLNIPA------------------V------TA--------MEWAHLH-------FFRELI--EALLKAY---QQ-TLFVTHTV B_taurus_ENSBTAP00000018959 N--DT-VSFLEYRS--YQFQPDKSRGQ-E--SDYIVMPNILV------------------L------SA--------SMMMENRP-----GLLKLMM--TLAFSTL---GQ-RAFMNRTV T_rubripes_ENSTRUP00000036580 N--GTRVVAYNTKS--FVFLPEKSVGDPS--VDSITTVNIPA------------------W------AV--------MNKVKGS------FFRSGMV--AMWMNSV---NS-GFFTTRTV G_aculeatus_ENSGACP00000021517 N--NTMVSAYNFKK--FVFLREKSVGDPA--VDNITTVNIPA------------------W------AV--------MNKVKGS------FFRASMA--SMMMTSA---GS-GFFATHTV R_norvegicus_ENSRNOP00000001301 N--DT-VSYIENRS--LRFQPDRSQGS-E--SDYIVLPNILV------------------L------GG--------AVMMEDKP-----TSLKLLM--TLGLVTM---GQ-RAFMNRTV P_pygmaeus_ENSPPYP00000005810 N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------L------GA--------AVMMEDKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV M_musculus_ENSMUSP00000083242 N--DT-VSFVENRS--LHFQPDKSHGS-E--SDYIVLPNILV------------------L------GG--------SILMESKP-----VSLKLMM--TLALVTM---GQ-RAFMNRTV D_rerio_ENSDARP00000076810 N--GTKVAAYTPKV--FVFVPEKSVGDPS--VDMVTTVNIPA------------------V------AV--------MNRIKGAG-----FLVSSAM--SLYMKSI---GA-EMFMTHTV A_carolinensis_ENSACAP00000012360 N--DTEVSSLNPKT--YFLDREMSVGDPE--VDLIRTVNVPA------------------V------VA--------MNLATST-------PLHLPA--EILLLLY---EE-ELFTIHTV X_tropicalis_ENSXETP00000002583 N--GT-VSFVEFRT--FHFDPEKSNGK-E--EDHVIVPNILV------------------L------GS--------SVMLQDLG-----IAIKWII--SGAFSAF---NE-EAFINKTV C_familiaris_ENSCAFP00000010357 N--DT-VSFLEYRS--FQFQPDKSHGL-E--SDYIVMPNILV------------------L------AA--------AMMMEDKP-----MSLKLIM--TLAFSTL---GE-RAFMNRTI C_intestinalis_ENSCINP00000025688 N--DT-VAYKYNHT--LVFVSEGSYNHPS--KINITQVNIPL------------------F------TI--------KELIKTLP-----SWGETII--SNLVTLL---KDSDVFVTHSA T_guttata_ENSTGUP00000016695 S--AE-IKFIFEIP--ASYFIKKNVLL-L--CNLWPVVVLLR------------------S------AV--------PSVYPS-------TLMQSVI--NTWVKSS---KA-AILQNRTV O_latipes_ENSORLP00000000458 N--GTKLYALNPKS--FVFVPEKSAGNPE--VDMVTTINIPF------------------V------AV--------MDELNSYS-----FFLRSMV--SIYMSSL---GV-DVFMNRTV A_gambiae_AGAP004846-PB N--GT-ISYNQKRV--YIFNEDLSGGL-E--DDVVIVPNIPM------------------L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVEVSV M_mulatta_ENSMMUP00000038414 N--DT-VSFLEYRT--FQFEPSKSHGS-E--SDYIVMPNILV------------------L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV D_melanogaster_FBpp0072308 N--GT-LSYNLRKI--YSFREDLSVGP-E--DDVVIVPNIPM------------------L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVQVSV A_aegypti_AAEL000256-PA N--GT-ISYNQKRV--YIFDEEQSEGT-E--DDVVIVPNIPM------------------L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVEVSV E_caballus_ENSECAP00000021856 N--DT-VSFLDFST--FSLGPGGPLSP-P--PGVLSLPGTRC------------------F------SA--------AMMMEDRP-----MSLKLMM--TLAFTTL---GE-RAFMNRTV D_melanogaster_FBpp0110185 G--SK-ISYVQNVH--FDFDAVASAPYTQ--DDRIVALNMHM------------------N------SV--------LQISENDP-----GLALLLVHLNANLKAVFNDPR-SMFVSTSV D_rerio_ENSDARP00000089887 N--HT-VSYKEYRQ--YFFEESMSVGD-E--SDVVTIPNMLV------------------L------GA--------SVMMENMP-----FPVRLLL--STTFKTF---NE-GPFLTKPV A_gambiae_AGAP010133-PA N--NT-VTYEQRRT--WHFVPELSKGTL---DDQVTNLNVIT------------------L------NA--------AHFLRNTY-----PLLRPLI--NIFLKTD---GS-LLWKNKPV D_melanogaster_FBpp0079088 N--AS-VTYRRRSL--FYFDAAGSNGSL---DDEITTLNAVA------------------L------SA--------AATAKYWP-----PVKRSLV--DVGLKMY---GA-EMSVQKSI A_gambiae_AGAP004845-PA D--GT-ISYREHRY--IQYLPEESKGK-P--FDQVVVPNVVF------------------L------TG--------VSKKRSEG-----TWNQIAF--NMAASSS---GS-SAFIKKPV A_gambiae_AGAP005716-PA R--SK-VHFSQQQM--YVFDAESSYPLTE--NDELTVLNMHM------------------N------SI--------LQIAEDET-----YDSLRLI--NVELNRIFGRPD-TMFLRTTP A_aegypti_AAEL000227-PA N--GT-ITYKELRS--YQFLANQSSGM-Q--YDKVVVPNIPM------------------I------TA--------ISQSADES-----LFKKMVL--NTALSGV---DA-KAFKVLPV A_gambiae_AGAP003373-PA N--AT-VSYRKKSL--YYFDEEGSNGSL---DDVISSINIVA------------------V------SA--------AKRSKYWG-----YLKQKGV--SLGLNVY---EQ-KINVVKTA D_rerio_ENSDARP00000071723 N--GTRVAAINPKT--YVFEPNMSRG-SQ--DDLVRTVNIPA------------------V------IR--------AQENTLNT---YKFFPLILI--SDLMKAK---GV-GVFETFRV D_melanogaster_FBpp0077748 N--AT-VAYYERRT--WFFDPERSNGTL---DDMVTAAHAIT------------------A------TV--------ADEMRDQR-----KIVKKII--NFMLNHE---GG-KLYVTKPV O_cuniculus_ENSOCUP00000002939 N--GTTISAVSNKA--YVFERNQSVGDPK--IDLIRTLNIPV------------------L------TV--------IELAQNP-------LLREIV--EAMLKAY---QQ-KLFVTHTV C_intestinalis_ENSCINP00000011713 N--DT-VAYKYNHT--LVFVSEGSYNHPS--KINITQVNIPL------------------F------TI--------KELIKTLP-----SWGKTII--SNLVTLL---KDSDVFVTHSA A_gambiae_AGAP002738-PA N--GT-VSTRPHHP--LIFQKGMSGNLRE--DDVFMMPNIAL------------------L------SI--------AHVAAKQP-----YFIRWPI--NLLIRQT---KV-QPLERQTA A_aegypti_AAEL009423-PA N--NT-VTFNQRRT--WNFDPELSRGSL---DDTVTNLNVIS------------------L------NT--------AYFMRNAP-----TLSKMAV--EVLLSLD---GS-LIWENKPV D_melanogaster_FBpp0072303 N--FT-VSFRDRKS--YKFLPEKSSIG-E--HEVVRVPNVPL------------------I------SA--------AGPVKRMK-----AFERLAV--STWIKQF---KE-PLFKNLTV A_gambiae_AGAP008179-PA N--DT-LTFQQRRI--WYHVPELSAGDYE--TDRVVTINPVL------------------L------TV--------GYALRNEP------EFLFYVDGIIMLNGL---AT-TPFYDVLV A_gambiae_AGAP005725-PA N--YT-VTYQHKKI--LQFVPELSVD--K--NLRITTPNIPL------------------L---------------------YLS-----FFVAKTI--SVILTAT---KY-KPFISLTA G_aculeatus_ENSGACP00000018249 N--GTKLYALNPKT--FVFVPEKSAGNPE--VDLIRTVNIPF------------------V------AI--------MNELNSYS-----FFLRTAV--SMYLKSL---GI-EVFMTRTV A_aegypti_AAEL009432-PA E--DT-LTFSQRRT--WHFEPELSKGDLE--NDKVVTINPIL------------------L------TL--------GFTMKDSP-------FLPFI--NALLNENPQFVD-NPFYNLRA G_gorilla_ENSGGOP00000006367 N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV D_melanogaster_FBpp0079175 N--AS-VSFHKKSW--FYFDAAGSNGSL---WDKVTTVNSVA------------------H------SA--------ARRAAVD------WFARTGV--NIANKLY---RQ-GVTITKTV D_melanogaster_FBpp0112038 N--YT-VSYQHKKI--LQFVPELSID--K--DTPITTPNIPL------------------L------TL--------TSLSPKLG-----YLLSKTI--SVVVTAA---QF-KPFINVTA A_aegypti_AAEL011222-PA N--GT-LYTKPSHP--LVFQAHLSAGHKE--DDVFYLPNIAL------------------L------SI--------AQVASKHN-----YLIRLPL--NLLIRQT---KT-VPLEKQTA C_intestinalis_ENSCINP00000010908 ------------------------------------------------------------------------------------------------------------------------ C_elegans_C03F11.3 G--EF-MEFRQIQT--FVFNPNKSCAGCDPYKDKVLIPDMGFQVGIDQIDTVIEGILKNPL------AATICHAIMKGKPNANQTCSNLGALIEGEL--GTLISLF---NV-SPFTTVTV A_aegypti_AAEL005979-PA N--YT-VTYQHKKI--LQFVPELSVD--K--NQRITTPNIPL------------------L------TI--------STQSKHLG-----YFLAKTI--SLVLTAT---KY-KPFISLTA D_melanogaster_FBpp0110565 N--NT-MSSTPSHP--LVWQEEMSGNCRE--DDEVVMLNIAM------------------L------AI--------SHLTANQP-----FLVRMAL--KTLLLST---KS-EPIVRTTA D_melanogaster_FBpp0080584 N--GT-VTFNPRRT--WFWEEELSGGKQ---TDLITAPHLPS------------------L------AA--------SNQMRNSN-----VFLKFMF--NEALNAN---GG-HLFVTHTA D_melanogaster_FBpp0079173 N--ST-VSYRRRSR--FDFDPKLSVGRP---TDPIVAPNLLI------------------V------GL--------YQKMVMWS-----PMLRSLM--LLALNIY---GK-EQAMIRPA D_melanogaster_FBpp0083430 E--DT-VSFTMRNT--FIFNPKESLPLTG--EEEIILPHPIM------------------L------PG--------GISVQREK-----AAMMELV--SKGLSIV-FPDA-KAFLKAKF C_elegans_Y76A2B.6 N--GT-VKYRRFFT--YNFNEQESCQTCI-LGNRIWVPNMIY------------------Q------KF--------VEAASTEG----------MK--AAATTLL---SQ-TAFLEVEV D_melanogaster_FBpp0082805 N--NT-ITYSPKRE--YVFAPERSVGDPK--IDRIRAPNIPL------------------M------GV--------TTLASSLS-----MFAALGL--SAITRQL---NS-QPMLEMSV A_aegypti_AAEL002741-PA N--GT-LSFTPIRR--QVFVPGRSVGDPR--HDLIIVPNIAY------------------L------GV--------ASAAYRMS-----AWASIAV--AAALKPL---GM-SPFLNITV C_elegans_Y49E10.20.1 D--TR-VFYKNQKL--YHFNKNASCPTCH-LDMKVTIPNIVF------------------Q------KL--------IDAADVTI---FGVRIKFAI--ESVLKMV---SE-APYITVKV A_aegypti_AAEL008370-PA -------------------------------------------------------------------SA--------ANRARTWD-----YVRRKGV--SMGLSLY---DQ-DVFVAKTA A_aegypti_AAEL005374-PA D--DT-LTFTLKNT--WIFRPDLSKPLTG--DEMITIPHPLI------------------L------GA--------LLMVQRDR-----EAMMPLV--SKGMDIIMNPLT-TGFLTTRV D_melanogaster_FBpp0080585 Q-----VTYFGKRT--WHFLPEKSNGSL---DDVVIAPHFPT------------------L------TA--------ALYSRRLR-----RILRKVM--NFTLNRE---GG-ATHMTHTA A_gambiae_AGAP004643-PA N--GT-LSFVPVRR--QVFVPERSVGDPK--QDRIMIPNIAL------------------L------GV--------SSAAYRMS-----TFAAFAV--AAALKPL---GM-SPILNITT A_aegypti_AAEL007748-PA N--ST-ISYRRRSY--FAPDDLLDESLL---TRSVTNLNVVA------------------L------TA--------ANRGKTEG-----YGAERGI--SFALYNL---DQ-KVLVTQQA A_gambiae_AGAP002451-PA ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008199 N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV A_gambiae_AGAP010132-PA N--DT-ITFNQKRI--WHYMPELSNGDYF--NDRVTTLNPVL------------------A------TV--------GKTLEGDP-------LLPLLDGIIMANNL---AE-FLYKDVPV A_aegypti_AAEL009420-PA D--HT-ITFKQKRT--WQYVPEQSGGDFY--TDRVTTPHTIL------------------M------TV--------GKLVAEMD----DPTLGDLV--NIILNNNDLVDG-ITYKDVLV A_aegypti_AAEL000234-PA N--ST-ISYNSRRQ--LHFMSELNESGIL--NKTIIIPNTAV------------------L------AM--------AAKLQNSN-----SLVKWGY--RAILSSS---GD-KVFVNTTI C_intestinalis_ENSCINP00000027668 DVPQQ-VYYRQKTM--IVFDRERSAGDL---SDLVTTVNPIG------------------A------SMPAIVDFVFSQRNQTTP-----DAIYSAL--NTIYRTT---GT-ELIFTRSV A_gambiae_AGAP004847-PA N--ST-ISYVTRRR--LVFLPDRNVPGIL--NKTIIVPNISL------------------L------GV--------AARMENDN-----FFMKRGF--NFIYSMS---GD-TVFSRMTI A_gambiae_AGAP012849-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_F11C1.3 D--NE-IFYVNNKT--WVYDPTRSCEDCK-LSDSVQFANTAY------------------M------ST--------VFMQIYQP---AGPIVGFGL--DVLTILL---GE-QPLRTVTA D_melanogaster_FBpp0072310 N-----VRYRKHRYRVVEFLPEESVAP-DVLNWTITSTNNVI------------------L------GA--------ATKVKHTA-----PLAAFGF--DAALMME------DIFVTDSV C_elegans_F07A5.3 K--SQ-MFYQNYKK--YILSKDYSCEDCD-WDRNIVFPNPPG------------------L------GA--------VASMLDPQ-FQITKTGRTII--AVALTIL---GE-YPFVSHKV C_elegans_R07B1.3 K--TK-MFYQNYKQ--YHYSEVDNDAGYN-YNDKIMFPNSIA------------------E------GA--------VSTVFGPQ-SEFSPTAKILV--SIGLVML---GE-YPFISKTV A_gambiae_AGAP000016-PA N--GT-LSYRKRTF--FRPSGPHSTTTNGTESERIISVNFVA------------------L------LA--------SHFGHSMD-----YSVQREL--SFMLHNF---RQ-TVTVTRTI 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 KELLW-GYK---------DPFLSLVP---------Y---P------I----STTVGVFYPYNDTV--DGVYKV----------FNGKD-NISK--VAI-IESYKGK-------RN----- R_norvegicus_ENSRNOP00000008319 KELLW-GYK---------DPFLSLVP---------Y---P------I----STTVGVFYPYNNTV--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- R_norvegicus_ENSRNOP00000058398 KELLW-GYK---------DPFLSLIP---------Y---P------I----STTVGVFYPYNNTV--DGVYKV----------FNGKD-NINK--VAI-IDTYKGK-------RN----- C_familiaris_ENSCAFP00000009599 KELLW-GYT---------DPFLSLVP---------Y---P------V----NTKVGVFYPYNNTV--DGVYSV----------FSGKD-NVSQ--VAI-IDTYKGK-------KN----- P_pygmaeus_ENSPPYP00000020018 RELLW-GYK---------DPFLSLVP---------Y---P------V----TTTVGLFYPYNNTA--DGVYKV----------FNGKD-NINK--VAI-IDTYKGK-------RN----- P_troglodytes_ENSPTRP00000033093 RELLW-GYR---------DPFLSLVP---------Y---P------V----TTTVGLFYPYNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- B_taurus_ENSBTAP00000023750 KELLW-GYT---------DPFLNLVP---------Y---P------I----TTTIGVFYPYNNTA--DGIYKV----------FNGKD-DISK--VAI-IDTYKGR-------KN----- H_sapiens_ENSP00000308165 RELLW-GYR---------DPFLSLVP---------Y---P------V----TTTVGLFYPYNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- E_caballus_ENSECAP00000013084 KELLW-GYK---------DPFLSLVP---------Y---P------V----PTTVGVFYPYNNTV--DGVYQV----------FTGKD-NISK--VAI-INTYKGK-------KN----- M_domestica_ENSMODP00000021313 KELLW-GYK---------DPFLSLVP---------Y---P------I----DTTVGVFYPYNNTV--DGVYKV----------YNGKD-DISK--VAI-IDTYKDK-------KN----- B_taurus_ENSBTAP00000018902 KELLW-GYK---------DPFLSSVP---------Y---S------I----PTTVGVFYPYNNTA--DGVYKV----------FNGKD-DISK--VAR-IDTYKGK-------KH----- O_anatinus_ENSOANP00000005521 KELLW-GYT---------DPFLQLVP---------Y---P------V----DTTVGVFYPYNNTA--DGEYKI----------FTGKD-DISK--VAI-IDTYKDK-------RN----- G_gallus_ENSGALP00000013734 KEILW-GYK---------DPFLNKVP---------F---P------L----DPVLGVFYPYNGTS--DGLYRV----------YTGKE-DISK--TAI-IESYKNK-------RN----- O_cuniculus_ENSOCUP00000002156 KELLW-GYK---------DPFLSLVP---------Y---P------I----TTTVGVFYPYNNTX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XN----- T_guttata_ENSTGUP00000002704 KEILW-GYT---------DPFLDSIP---------F---P-----NV----KSFVGVFYPYNGTS--DGPYSV----------YTGAD-DITK--TAV-IESYKHG-------RT----- A_carolinensis_ENSACAP00000015615 KEILW-GYE---------DPFLKKIP---------I---P-----GV----VKKVGVFYPFNETL--DGLYTV----------YTGRE-DMSK--TAI-IHSYKNK-------SM----- X_tropicalis_ENSXETP00000017231 KELLW-GYR---------DPFLEKIP---------I---D-----SI----DKTTGLFYPNNGTA--DGIYHV----------YNGKG-DISK--VAI-IDRYKEA-------KA----- T_rubripes_ENSTRUP00000041076 KELLW-GYR---------DPTFFIET---------G-LFV-----SL----PTLSHVLHQYNGST--DGIYTV----------FTGKD-DISK--VGL-IDSWREK-------KK----- D_rerio_ENSDARP00000050752 KELLW-GYK---------DPMLNS-----------------------------LVGAFYPYNGTV--DGPYTV----------FTGKD-DINK--VAI-IERWQGE-------TS----- O_latipes_ENSORLP00000020106 RELLW-GYK---------DPLLFGMQ----------------------------MGLFSPYNGTY--DGYYNV----------FTGKD-DITK--VSK-IDMYRGN-------SN----- T_nigroviridis_ENSTNIP00000014345 RELLW-GYQ---------DPVLTALT---------G----------R----PDLTGLFVPYNGTA--DGVYTV----------YTGKD-DISK--VGL-IHSWRGN-------RT----- G_aculeatus_ENSGACP00000026365 KELLW-GYN---------DPLFKS-----------------------------QLGLFFPYNGTY--EGSFNV----------YTGKD-DISK--VGM-IDRWRGE-------RS----- G_gorilla_ENSGGOP00000005986 XXXXX-XXX---------XXXXXXXX---------X---X------X----XXXXXXXXXYNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- X_tropicalis_ENSXETP00000017237 KELLW-GYN---------DPFLEQIP---------F---P-----DI----DTTTGVFYP------------A----------FFTYL-NLLR--KHE-VQVAKGL-------WS----- T_guttata_ENSTGUP00000001744 HQLLW-GYK---------DRLLSTIH---------V-LHP-----EI----DPVFGLFNKMNGTD--DGEYVF----------LSGET-NYLN--FSR-IVEWKGK-------ES----- X_tropicalis_ENSXETP00000052043 DELLW-GYK---------DAVLSILH---------P-FKK-----NI----SDTFGLFYKMNTTD--DGEYIF----------LSGEK-DYLE--FTQ-IAEWKGQ-------KA----- M_mulatta_ENSMMUP00000027514 DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYEKNGTN--DGDYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- G_gallus_ENSGALP00000018715 HELLW-GYK---------DKLLSTIH---------V-LHP-----EI----DPVFGFFNKMNGTD--DGEYVF----------LSGEM-NYLN--FSR-IVEWKGK-------ES----- G_aculeatus_ENSGACP00000022821 GELLW-GYE---------DALLKALK---------T-LKP-----DL----DDVFGLFHKNNGSN--DGQYVF----------FTGHQ-SYQD--FAR-VDTWNGD-------RS----- H_sapiens_ENSP00000264896 DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYEKNGTN--DGDYVF----------LTGED-SYLN--FTK-IVEWNGK-------TS----- O_latipes_ENSORLP00000012225 GELLW-GYE---------DGLLKALK---------L-FRP-----EL----DDVFGLFYKTNASN--DGQYVF----------FTGQQ-SYED--FAR-VSTWNGE-------SS----- O_anatinus_ENSOANP00000014317 HELLW-GYK---------DEVLSLIN---------A-FRP-----DV----PQYFGLFYGKNATD--DGEYVF----------LSGED-DYLN--FSR-IVEWKGR-------TS----- P_troglodytes_ENSPTRP00000027814 DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYEKNGTN--DGDYVF----------LTGED-SYLN--FTK-IVEWNGK-------TS----- M_domestica_ENSMODP00000037525 HDLLW-GYK---------DELFSLIS---------I-FKP-----DI----SPYFGLFYGRNGTD--DGDYLF----------LTGED-NYLN--FTK-IVEWNGK-------RS----- P_pygmaeus_ENSPPYP00000016592 DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYEKNGTN--DGDYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- T_rubripes_ENSTRUP00000042953 HEVLW-GFK---------DPLLTKLH---------T-MRP-----EV----DEYFGLMWKKNGTH--EGEFVF----------HTGVE-NYLD--YGK-IDTWNGM-------RK----- R_norvegicus_ENSRNOP00000003052 HELLW-GYK---------DEVLSLVH---------I-FRP-----DV----SPNFGLFYERNGTN--DGEYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- O_latipes_ENSORLP00000001610 GELMW-GYD---------SKLVDFLN---------Q-YLP-----GMLP-SSGKFGLFAEFNNSN--TGLFTI----------NTGKD-DIRK--VHR-VDSWNGL-------TQ----- D_rerio_ENSDARP00000023056 HEILW-GFK---------DPLLTKLH---------A-MRP-----EV----DEHFGLMYNKNGTH--EGEFVF----------HTGEK-NYMN--YGK-IDTWNGI-------SQ----- P_troglodytes_ENSPTRP00000009553 GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAELNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- H_sapiens_ENSP00000261693 GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAELNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- M_musculus_ENSMUSP00000031377 HELLW-GYK---------DEILSLVH---------I-FKP-----DV----SPNFGLFYERNGTN--DGEYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- O_latipes_ENSORLP00000008151 HELLW-GYE---------DPLLEKAA---------G-YTP-----GL----DKAFGLMYKKNGSD--SGEFIY----------HTGEQ-NYLD--YGR-VKTWKGQ-------SK----- T_nigroviridis_ENSTNIP00000018658 HEVLW-GFK---------DPLLTKLH---------S-MKP-----EV----DEYFGLMWKKNGTH--EGEFVF----------HTGVE-NYLD--YGK-IDTWNGM-------RK----- G_gallus_ENSGALP00000004761 GEILW-GYE---------DPLLDTIN---------A-LVP-----GLIP-YKGKFGIFIEFNNTN--SGLFTV----------NTGMK-NISQ--VHM-VDSWNGL-------KK----- T_rubripes_ENSTRUP00000019814 GELLW-GYQ---------DNLLASLQ---------K-FQP-----QL----DDVFGLFYKSNASN--DGQYVF----------FTGEL-NYRD--FAR-VDTWNGE-------SS----- B_taurus_ENSBTAP00000014549 DELLW-GYK---------DEILSLIN---------T-FKH-----DV----SPYFGLFYGKNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- T_nigroviridis_ENSTNIP00000016587 GELMW-GYD---------SKLVDFLN---------K-YLP-----GMLP-SSGKFGLFTEFNNSN--TGLFTV----------HTGKD-DIRK--VHK-VDSWNGL-------TE----- E_caballus_ENSECAP00000022283 DELLW-GYK---------DEILSLIN---------I-FKP-----DI----SPYFGLFYGKNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- O_anatinus_ENSOANP00000002110 SEIMW-GYE---------DPFVEFLN---------K-YLP-----GMIP-FKGKFGLFAELNNSN--SGLFTV----------YTGVK-DFSK--IHL-VDKWNGL-------SK----- T_nigroviridis_ENSTNIP00000002999 GELLW-GYE---------DSLLRVAK---------K-FWP-----QL----DDVFGLFYKSNASN--DGRYVF----------FTGEQ-DYRD--FAR-VDTWNGE-------SS----- T_rubripes_ENSTRUP00000047691 GELMW-GYD---------SKLVNFLN---------K-YLP-----GMLP-SSGKFGLFSEFNNSD--TGLFTI----------HTGKD-DIRN--VHK-VVSWNGL-------TE----- T_nigroviridis_ENSTNIP00000010349 NELLW-GYQ---------DPLLTKVS---------A-TNP-----DV----EKVFGLMYKKNGSS--NGEFVY----------HTGQQ-DYLD--YGR-VETWKGQ-------RQ----- T_guttata_ENSTGUP00000005161 GELMW-GYD---------DPLVDAIN---------L-IFP-----GMLP-FKGKFGLFMDFNNSN--SGLFTV----------NTGMK-NISQ--VHM-VDSWNGL-------KM----- M_domestica_ENSMODP00000019581 GEIMW-GYS---------DPLIDLLN---------K-YFP-----GLMP-FKDKFGLFAQLNNSN--SGLFNV----------FTGVK-DFSK--IHL-VDRWNGK-------TK----- A_carolinensis_ENSACAP00000014578 DQILW-GYD---------NPLVDFLN---------S-IKP-----GMIP-FKGKFGLLADFNNSN--TGLFRV----------YTGVG-DISR--AHM-IDTWNGL-------KE----- C_familiaris_ENSCAFP00000012634 DELLW-GYK---------DEILSLIN---------V-FKP-----EI----SPYFGLYYGKNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- B_taurus_ENSBTAP00000018959 GEIMW-GYD---------DPLIHLIN---------Q-YFP-----NSLP-FKGKFGLFAELNNSD--SGLFTV----------FTGVK-NFSR--IHL-VDKWNGV-------SK----- T_rubripes_ENSTRUP00000036580 HELLW-GYE---------DPLLARVS---------S-SSP-----DV----EKVFGLMYKKNGSN--DGEFVY----------HTGQQ-NYLD--YGR-VETWRGE-------SQ----- G_aculeatus_ENSGACP00000021517 DEWLW-GYE---------DRLLARVA---------A-SSP-----DV----DKVFGLMYKKNGSH--SGEFVY----------HTGKQ-NSME--YGR-VETWKGE-------SK----- R_norvegicus_ENSRNOP00000001301 GEILW-GYE---------DPFVNFLS---------K-YFP-----DMFP-IKGKFGLFVGMNDSS--SGVFTV----------FTGVQ-NFSK--IHL-VDKWNGL-------SE----- P_pygmaeus_ENSPPYP00000005810 GEVMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAELNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- M_musculus_ENSMUSP00000083242 GEILW-GYD---------DPFVHFLN---------T-YLP-----DMLP-IKGKFGLFVGMNNSN--SGVFTV----------FTGVQ-NFSR--IHL-VDKWNGL-------SK----- D_rerio_ENSDARP00000076810 DELLW-GFK---------DPLLTKLR---------S-IKP-----ET----DEFFGLMLHKNGSD--DGEFVY----------HTGEH-NYLD--YGR-IFTWKGE-------KL----- A_carolinensis_ENSACAP00000012360 HELLW-GYT---------DKLLSALH---------K-FRP-----TI----DADFGFFKKMNGSD--DGEYIM----------LSGKK-NYLD--FTR-IIKWRGK-------DT----- X_tropicalis_ENSXETP00000002583 KDILW-GYE---------DPFLDFLN---------T-FLP-----GKLP-FKGKFGFFSDFNNSN--TGVFTV----------NTGME-DISR--VQM-VDNWNGL-------KK----- C_familiaris_ENSCAFP00000010357 GEIMW-GYE---------DPLIHLIN---------K-YLP-----NMLP-FKGKFGLFAELNNSD--SGIFTV----------FTGVK-DFSR--IHL-VDKWNGL-------SK----- C_intestinalis_ENSCINP00000025688 QELLF-GYP---------DPVLEMAS---------Q-FLK-----VFGVSLPGEFGAFYGFNNSD--DGIYLA----------NTGRS-DLSL--AND-LQRWNGM-------ES----- T_guttata_ENSTGUP00000016695 KEILW-GYT---------DPFLDSIP---------F---P-----NV----KSFVGVFYPYNGTS--DGPYSV----------YTGAD-DITKRHMTF-ILSY----------RT----- O_latipes_ENSORLP00000000458 HEILW-GFK---------DPLLSKIH---------S-MKP-----DV----DEYFGLMWKKNGTH--EGEFVF----------HTGEQ-NYLD--YGK-IDTWNGL-------RE----- A_gambiae_AGAP004846-PB GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLMYGKNSTS--KDTVTV----------WTGVD-DITQ--YGI-IDKYNGR-------SH----- M_mulatta_ENSMMUP00000038414 GEIMW-GYQ---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAELNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- D_melanogaster_FBpp0072308 GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLLYGKNGTS--SDRVTV----------NTGVD-DIRR--YGI-IDNFNGR-------TH----- A_aegypti_AAEL000256-PA GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLMYGKNSTS--KDRVTI----------WSGVD-DITK--YGI-IDKYNGR-------SH----- E_caballus_ENSECAP00000021856 GEIMW-GYE---------DPLMNLIN---------K-YFP-----NMFP-FKGKFGLFAELNNSN--SGLFTV----------FTGVK-DFSR--IHL-VDKWNGL-------SK----- D_melanogaster_FBpp0110185 REYLFDGVRFCINPQGIAKAICNQIK------------ESGSKTIREKSDGSLAFSFFGHKNGSG--HEVYEV----------HTGKG-DPMR--VLE-IQKLDDS-------HN----- D_rerio_ENSDARP00000089887 GELMW-GYD---------SKLVDFLN---------K-YLP-----GMLP-SSGKFGLFADFNNSN--TGLFTI----------FTGRD-DIRK--VHM-VDSWNGL-------KN----- A_gambiae_AGAP010133-PA RELLFEGVK---------DPLLDLLK---------TINST-----SLNI-PFDRFGWFVGRNLSDTFDGTFTM----------RTGAD-GLES--MGF-LTQWNGS-------PN----- D_melanogaster_FBpp0079088 DELLFTGYN---------DAMIDVAMAM-------PIFGD-----EVKV-PFDKFGWFYTRNGSADLTGVFNV----------FTGAD-QLAK--LGQ-MHSWNYQ-------EN----- A_gambiae_AGAP004845-PA ESMLW-GYE---------DKLLSLAK---------S-M-F-----GSDI-VSSSFGMLMTRNGTS--AENFTI----------FSGES-SLED--LAV-IKHLDGK-------SR----- A_gambiae_AGAP005716-PA KQFLFDGVPFCVNVIGIAKAICKEIE------------KRNTKTIRTMPDGSLRFSFFSHKNMTD--DGMFTI----------NTGIK-DPSR--TQM-IELWNGR-------TT----- A_aegypti_AAEL000227-PA DPFLW-GYE---------DDLLNLAK---------K-FSF-----DNEI-SFSKFGILMTRNGTS--AETFTI----------YSGEN-DLKQ--LAI-IKDLNGK-------SS----- A_gambiae_AGAP003373-PA GELLFDGYE---------DNMVLMGK---------HMFD------ADEV-PFDRVGWFYTRNNSADLIGHYNV----------HTGVE-DIGM--LGK-MGEWNYK-------PR----- D_rerio_ENSDARP00000071723 GDLLW-GYE---------DPLLKELH---------M-LVP-----------DDHFGLFYKKNGTE--YDSYVL----------LTGKP-DYQD--FAS-IDEWNGQ-------RS----- D_melanogaster_FBpp0077748 GEWIFEGYQ---------DNITDFLN---------LFNTT-----KIDI-PYKRFGWLADRNESLTYDGLFTI----------HTGTD-DISN--LGR-LTHWNGK-------SE----- O_cuniculus_ENSOCUP00000002939 DELLW-GXX---------XXXXXXXX---------V-FRS-----DI----SPYFGLFYGXXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XA----- C_intestinalis_ENSCINP00000011713 QELLF-GYP---------DPVLEMAS---------Q-FLK-----VFGVSLPGEFGAFYGFNNSD------------------------------------------------------- A_gambiae_AGAP002738-PA REFMY-GYP---------TTLTTLGY---------T-FLP-----NWIS--FDKVGLIDRMYDFD--DDFETF----------YTGET-TASV--SGL-YDTYLGS-------PD----- A_aegypti_AAEL009423-PA RNLLFEGLD---------DPLLDLLK---------TLNNT------VKL-PFDKFGWFVDRNLSDTYDGTFTM----------KTGAD-SLEN--TGM-LTLWNGQ-------AQ----- D_melanogaster_FBpp0072303 SEYLW-GYE---------DSIIKLKS---------------------LGRGRRRFGLLMSRNGTS--VDSVQL----------NTGED-DITK--FSI-ITQFNGM-------PQ----- A_gambiae_AGAP008179-PA REMIFEGYD---------DTLLTNLLAL-------LALLPEESRPPIDLPPYDRFGWFFGRNGSETYDGTFTI----------GTGKD-SVYN--TGV-MRLWNGA-------NA----- A_gambiae_AGAP005725-PA DELVF-GYD---------DTLVSLAH---------R-FYP-----RNRR-PMEKMGLLNGRNGTL--TEYATM----------HTGHT-GMDK--FGY-FDKLNGL-------DH----- G_aculeatus_ENSGACP00000018249 HEVLW-GFK---------DPVLTKVH---------S-LKP-----EV----DEYFGLMWKKNGTH--EGEFVF----------HTGEE-NYLD--YGK-IDTWNGL-------RK----- A_aegypti_AAEL009432-PA KDVLFDGYE---------DLLLKNLLQV-------VEQNPVLGE-EFDLPPFDKFGWFYGRNESETYDGNFTI----------GRGTD-GFQN--LGI-LKLWNAA-------NH----- G_gorilla_ENSGGOP00000006367 GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAEXXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XX----- D_melanogaster_FBpp0079175 DEMLFKGYE---------HPFISVGK----------LLRP------QDV-PYKRIGYHYPRNGSSEFDGDINM----------FTGAD-DIAK--MGQ-IHTWNNL-------TH----- D_melanogaster_FBpp0112038 EQLAF-GYD---------DALVSLAH---------R-FYP-----KHMR-PMERMGLLLGRNGTL--TEVSSV----------KTGMD-SMDQ--FGY-IDQLNGL-------DH----- A_aegypti_AAEL011222-PA RQFMF-GYE---------TTLTTLGN---------T-FLP-----NWIS--FNKVGLIDRMYDFD--NDFETF----------YTGVD-DESL--SGL-YESYLGS-------PK----- C_intestinalis_ENSCINP00000010908 ---------------------------------------------------------------------------------------------------------M-------SE----- C_elegans_C03F11.3 DQLLFSGYK---------TPFVEKFLDEALGMLHFLFGTA-------PKPLDDPPIQLNPLNGTS--DIINTV----------LTGKT-DPLK--AGY-MTEFRSI-------SNNSLFN A_aegypti_AAEL005979-PA DELVF-GYD---------DTLVSLAH---------R-FYP-----RNRR-PMSKMGLLNGRNGTL--TEYATM----------YTGHT-GMEK--FGY-FDKLNGL-------DH----- D_melanogaster_FBpp0110565 KEFMF-GYP---------SALATLGN---------T-FLP-----NWIS--FEKVGLIDRMYDFS--TDFETF----------YTGVP-NPAL--SGL-YASYRGE-------TT----- D_melanogaster_FBpp0080584 AEWLFESFY---------DEFLHYAM---------TLNNP-----LVPKIESDHFAWFLNRNGSKDFEGPFTV----------HTGVG-DIKE--MGE-IKYWKGQ-------NH----- D_melanogaster_FBpp0079173 SDWMFDGFD---------TPMIKMSKMVP------PSLVP-----EMKF-PYEKIGYAYPRNGSMEIYGHHNV----------YTGRD-EFQK--LGQ-IARWRYN-------NV----- D_melanogaster_FBpp0083430 MDLFFRGIN---------VDCSSEEFSAKALCT--VFYTGEIKQAKQVNQTHFLFSFMGQANHSD--SGRFTV----------CRGVK-NNKK--LGK-VVKFADE-------PE----- C_elegans_Y76A2B.6 EELLFEGYK---------DPFLDKVCEIPF-----MNFVC-----EAILDVPERIGLFFKANGTG--SKVYEI----------DDGTR-NPDD--LGK-ILSYDES-------PI----- D_melanogaster_FBpp0082805 HDYMW-GYE---------DHLVELAS---------R-FVP-----NWID--FSSFGIMEKLFREGNESNVFNM--NLPEPKDKYGMRMTDAPR---GYTVDSINGE-------RG----- A_aegypti_AAEL002741-PA HDLLW-GYE---------DPLVQVAS---------T-LLP-----NIIH--FKKIGILDRVKLDS-IEEDYFAGDALQVAAEEEAEES-DEPI--RNYSIDLWNGS-------PG----- C_elegans_Y49E10.20.1 SDALFDGYE---------DPIIDIVC-----------KNKILQFLCETNSLQRRVGFFYGQNGTT--DGIYEV----------DAGVP-SPSK--IGH-LYTWNNM-------TE----- A_aegypti_AAEL008370-PA GELLFDGYE---------DNMVLMGK---------QLFD------ASEV-PFDRVGWFYTRNNSADLIGHYNV----------HTGVD-DIMK--IGS-MAEWNYK-------PR----- A_aegypti_AAEL005374-PA MDLLFDGIL---------IDCSSHEFSAKAL----CSGLESEGAVMPFNETHFKFSMFGLKNGTD--AGRWVV----------YRGVK-NIMD--LGR-VVSFNDE-------TE----- D_melanogaster_FBpp0080585 GQWLFDGYY---------DHLLDFVE---------QLHSP------LLPVYDNTFGWFYERNNSKTAEGNFTL----------HTGRG-DLSQ--LGD-LLLWNGE-------NT----- A_gambiae_AGAP004643-PA HDLLW-GYD---------DPLVRIAS---------T-LLP-----DIIH--FQKLGVLDRMFDDG--FDTVTINLPQSVHNQRHDAEI-DILP--EDISDDLIVGL-------EE----- A_aegypti_AAEL007748-PA GELLFDGYP---------EPMIQEMLDV-------LGTTP-----HNGLDVEDRFGWFRAVNGSKKFHGFFNM----------NSGKE-DASR--YGL-IRQWNYR-------DR----- A_gambiae_AGAP002451-PA ------------------------------------------------------------RNHTE--AGRWVV----------YRGVK-NIRD--LGR-VVSYNEE-------TE----- G_gorilla_ENSGGOP00000008199 DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYEXXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XS----- A_gambiae_AGAP010132-PA HEMLFDGHP---------DTLLTTLRDL-------LGALPPGTVPDISLPPWEGFGWFVERNESLTYDGTFQM----------GTGTD-NHIN--TGV-MRQWNNA-------PQ----- A_aegypti_AAEL009420-PA RDILFDGAE---------DRLLAALQNL-------LALLPEVPE-GVELPPWDGFGYFIDRNTSAEYDGIFRM----------NTGTD-SWTN--TGQ-MRTWNDE-------PT----- A_aegypti_AAEL000234-PA FNYLW-NQT---------SPIIKSAR---------K-IVP-----FMVP--LENIGALSVMYNDY--NDRVNV----------RHGVQHGDNQ--FFM-INSYRNR-------PT----- C_intestinalis_ENSCINP00000027668 NDILF-GFQ---------DNFFDLIA---------------------------------------------------------------------------------------------- A_gambiae_AGAP004847-PA YDYLW-NTR---------PPFLDQAR---------K-FVP-----GMVP--SDNVGVLKTMYEDH--EDHVNV----------RHGKRYGDDQ--FFM-MNTYEYE-------PT----- A_gambiae_AGAP012849-PA --------------------------------------------------------------KSLTYDGTFQM----------GTGTD-NHIN--TGV-MRQWNNA-------PQ----- C_elegans_F11C1.3 GGTLFDGYN---------DPLITLINSPLVKVLLSVLGNP------VQLPQVPAAGFFPHYSHTC--DGNYTI----------RTGKD-NTDY--VGQ-IKTWNGL-------TH----- D_melanogaster_FBpp0072310 YYFLW-EFT---------RPLLQTLS--------------------RISNIRPNVAVLYNALKEK--EEVYTV----------NIGPKRGIEN--FFR-IETLNGEVIIREQLPH----- C_elegans_F07A5.3 REVLFDGYE---------DALLSAAHSGFVTVLSGIFKGDGGSIVPIPIPAMPKFGYFQGYNNSR--DEEYWI----------ETGKK-DINQ--IGN-VQRWAGI-------TE----- C_elegans_R07B1.3 KDVLMDGYE---------DPLLSVAHSGIFISLVNFYGYGSQ---LNYIPEMKTFAYLSGYNNSY--DENYWI----------NTGYN-DFNK--LGF-VESWAGL-------EQ----- A_gambiae_AGAP000016-PA GQLLFTGYR---------EPMMEPLR---------KLVCPTKR--RSVACQDERLAYFRTFNVTRRASEVYSL----------DVGLK-DRSK--YGT-VRSWGAA-------SV----- 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V-EKSRTLRFFSSDICRSIYA-VFGS--EIDL-KGIPVYRFVLP-ANAF-ASPLQNP-DNHC R_norvegicus_ENSRNOP00000008319 -----LS--YW-------------------E--SYC--DMING--TDAASFPPF----V-EKSRTLRFFSSDICRSIYA-VFGS--EVNL-KGIPVYRFVLP-ANAF-ASPLQNP-DNHC R_norvegicus_ENSRNOP00000058398 -----LS--YW-------------------K--SYC--DMING--TDAASFPPF----V-EKSRTLRFFSPDICRSIYA-VFES--EVNL-KGIPVYRFVLP-VNAF-ASPLQNP-DNHC C_familiaris_ENSCAFP00000009599 -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V-EKTRVLRFFSSDICRSIYA-VFGA--EINL-KGIPVYRFVLP-SMAF-ASPLQNP-DNHC P_pygmaeus_ENSPPYP00000020018 -----LS--YW-------------------E--SYC--DMING--TDAASFPPF----V-EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVQNP-DNYC P_troglodytes_ENSPTRP00000033093 -----LS--YW-------------------E--SHC--DMING--TDAASFPPF----V-EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVENP-DNYC B_taurus_ENSBTAP00000023750 -----LS--YW-------------------S--SYC--DLING--TDAASFPPF----V-EKTRVLQFFSSDICRSIYA-VFGA--EINL-KGIPVYRFILP-SFAF-ASPFQNP-DNHC H_sapiens_ENSP00000308165 -----LS--YW-------------------E--SHC--DMING--TDAASFPPF----V-EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVENP-DNYC E_caballus_ENSECAP00000013084 -----LS--YW-------------------S--GYC--DMVNG--TDAASFPPF----V-EKTRVLQFFSSDICRSVYA-VFGA--DVNL-KGIPVYRFVLP-SKAF-ASPLQNP-DNHC M_domestica_ENSMODP00000021313 -----LS--FW-------------------P--GYC--DMING--TDAASFPPF----V-EKTRILRFFSSDICRSIYA-EFEH--EVNL-KGIPVYRFVLP-SKAF-ASPTVNP-DNDC B_taurus_ENSBTAP00000018902 -----LS--YW-------------------P--SYC--GMING--TDGATFPPF----I-EKNRVLQFFSADICRSFYA-VFGA--EINL-KGIPVYRFVLP-SRIF-ASPLQNP-DNHC O_anatinus_ENSOANP00000005521 -----LS--YW-------------------P--GYC--DMINGTETDAASFPPF----L-DKNRVLQFFSSDICRSIYA-KFER--EINL-KGIPVYRYVLP-RMAF-ASPVENP-DNYC G_gallus_ENSGALP00000013734 -----LS--YW-------------------E--GYC--DLVNG--TDGASFPPF----V-KKNQVLRFFSSDICRSIYG-VYQT--SKTV-KGIPLYRFTVP-REAF-ASPIDVG-DNYC O_cuniculus_ENSOCUP00000002156 -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V-EKSRVLQFFSSDICRSIYA-VFGS--EINL-KGIPVYRFVLP-AKAF-ASPVQNP-DNHC T_guttata_ENSTGUP00000002704 -----LS--YW-------------------K--GHC--DMVNG--TDGASFPPF----V-KKDQVLRFFSADICRSIYA-VFHS--KQLV-KGITLYRFVVP-REAF-ASPAEVR-DNYC A_carolinensis_ENSACAP00000015615 -----LP--YW-------------------G--GYC--DMING--TDGSSFPPF----V-SRNNVLQFFSSDICRSIYG-YFDS--DQLV-KDIPLYRFIVP-PNAF-ASPLVNP-DNIC X_tropicalis_ENSXETP00000017231 -----LP--YW------------N------D--DFC--DMING--TDAASFPPS----V-KKDKRLYFFSSEICRSIYG-IFEK--EYMV-KGIKLYRFVVT-EDAM-ASPTKNP-DNHC T_rubripes_ENSTRUP00000041076 -----LD--FW------------E------D--QYC--DMING--TDASSFPPF----V-DKSKPLYFFSSDICRSVSA-SFQQ--SMDL-KGIEVYRFTLQ-PNTL-AAPTDNP-DNHC D_rerio_ENSDARP00000050752 -----VN--YW------------N------D--SYC--DKING--SDGSSFHPF----L-DKKEPLYFFSPDICRSISA-EYEA--TVNL-KGIDVYRYLLP-VDAL-ASPVSNP-DNMC O_latipes_ENSORLP00000020106 -----LG--FW------------N------D--SYC--DMING--TDASSFAPF----L-DKETPLYFFSSDICRSVSA-SYEQ--TVDL-KGIDVYRYSLL-PSTL-ASPVVNP-DNRC T_nigroviridis_ENSTNIP00000014345 -----VN--FW------------Q------D--RYC--DMING--TDASSFPPF----L-DQTKPLFFFSSDICRSVSA-SFER--SRDL-RGIRVFRYVLL-PETL-AAPVDNP-DNHC G_aculeatus_ENSGACP00000026365 -----LH--FW------------N------D--TYC--DMING--TDASSFSPF----V-DKKTPLYFFSSDICRSVSA-SFEA--SHDL-KGIEVYRFALQ-QNTL-DAPNVNP-DNRC G_gorilla_ENSGGOP00000005986 -----LS--YW-------------------E--SHX--DMING--TDAASFPPF----V-EKSQVLQFFSSDICXXXXX-XXXX--XXXX-XXXXXXXXXXX-XXXX-XXXXXXX-XXXX X_tropicalis_ENSXETP00000017237 -----LS--YW------------N------G--DNC--NMING--TDAFLFSPF----N-KKKNHLFFFSPDACRSLYG-VFEK--EYDL-KGIKMNRFVVP-KEVF-ASSAENS-DNHC T_guttata_ENSTGUP00000001744 -----LS--WW------------T------T--EAC--NMING--TDGTSFHPL----I-SKDENIYIFSSDFCRSLFL-VYDS--SGDV-AGVPTFRFVPS-SMVF-ANTSVNP-ANAG X_tropicalis_ENSXETP00000052043 -----LN--WW------------T------T--ETC--NMING--TDGTSFHPL----L-NKDDTIYMFSSDLCRSIYA-VYES--SENI-KDISVFRFSPP-ASVF-ANVSVNP-QNKG M_mulatta_ENSMMUP00000027514 -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I-TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG G_gallus_ENSGALP00000018715 -----LN--WW------------T------T--KTC--NMING--TDGTSFHPL----I-SKDENIYIFSSDFCRSLYL-VYDS--SGSV-AGVPTYRFVPS-PMVF-ANTTVNP-DNAG G_aculeatus_ENSGACP00000022821 -----LS--WW------------T------S--DEC--NMING--TNGASFHPV----I-AKNETLYMFSSDLCRSLYA-VYEE--DVTV-KGIPAYRFSPP-SDVF-ANHTVNP-ANAG H_sapiens_ENSP00000264896 -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I-TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG O_latipes_ENSORLP00000012225 -----LN--WW------------T------S--KEC--NMING--TNGASFHPV----I-TKNELLRIFSSELCRSLYA-VYED--DVSV-KGIPGYRFILP-SEVF-ANESVNP-ANAG O_anatinus_ENSOANP00000014317 -----LD--WW------------A------T--KKC--NMING--TDGNSFHPL----I-TKDEDLYIFSSDFCRSVYV-GFTD--SVDV-RGIPAFRFKMP-RELL-ANNS----DNAG P_troglodytes_ENSPTRP00000027814 -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I-TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG M_domestica_ENSMODP00000037525 -----LS--WW------------A------A--EKC--NMING--TDGNSFHPL----I-SKDETLYIFASDFCRSVYL-KFSD--MGNV-EGIPSLRFTVP-PEMF-ANNS----DNSC P_pygmaeus_ENSPPYP00000016592 -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I-TKDEVLYIFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG T_rubripes_ENSTRUP00000042953 -----MN--WW------------S------S--NQS--NMING--TDGAVFHPL----I-NRNELLYIFAADLCRSIHL-AYVE--DVEV-KGIQAYRFAPP-SDVL-MSPKENP-TNEG R_norvegicus_ENSRNOP00000003052 -----LD--WW------------T------T--DTC--NMING--TDGDSFHPL----I-SKDETLYIFPSDFCRSVYI-TFSS--FENV-EGLPAFRYKVP-AEIL-ANSS----ENAG O_latipes_ENSORLP00000001610 -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M-TKESTLPFYSPDACRSLEL-VYQR--TGEM-LGIPLYRFVAP-RTMF-ANGSQYE-PNQG D_rerio_ENSDARP00000023056 -----MN--WW------------S------S--NQS--NMING--TDGSVFHTF----L-SRKELLYIFAADLCRSIHL-GYVR--DMEV-KGIPAFRFAPP-SDVL-APPDENP-ANAG P_troglodytes_ENSPTRP00000009553 -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M-TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG H_sapiens_ENSP00000261693 -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M-TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG M_musculus_ENSMUSP00000031377 -----LD--WW------------T------T--DTC--NMING--TDGDSFHPL----I-SKDEVLYLFPSDLCRSVHI-TFSS--FENV-EGLPAFRYKVP-AEIL-ANTS----ENAG O_latipes_ENSORLP00000008151 -----LT--FW------------T------S--EES--NRIQG--SDGSSFHPL----L-KKDERIYIFTPDLCRTIYM-DFEK--EVEV-KGIPAYRFTPP-RSVF-ASKEENS-DNEG T_nigroviridis_ENSTNIP00000018658 -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I-NRNELLYIFAADLCRSIHL-AYVK--DVEV-KGIQAYRFAPP-SDVL-MSPKDNP-TNEG G_gallus_ENSGALP00000004761 -----VN--YW------------R------T--NEC--NMING--TAGEMWPPY----M-SP-TSLEFYSPDACRSMTL-VYEQ--SGKF-KGVPTYRFVAP-KTLF-ANGTDYP-PNEG T_rubripes_ENSTRUP00000019814 -----LN--WW------------S------T--AEC--NMING--TIGASFHPV----I-TKDEMLYIFSSDMCRSLYA-IYEE--DVVV-KGIPAYRFSPP-SEVF-GNTT----ANAG B_taurus_ENSBTAP00000014549 -----LD--WW------------T------A--DEC--NMING--TDGDTFHPL----I-TRDEVLYVFPSDFCRSVYI-TFSD--FESV-QGLPALRYKVP-AEIL-ANTS----DNAG T_nigroviridis_ENSTNIP00000016587 -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M-TEESTLPFYSPDACRSLEL-VYQR--SGEM-KGIPLFRFVAP-KTLF-ANGSDYA-PNEG E_caballus_ENSECAP00000022283 -----LD--WW------------T------T--DRC--NMING--TDGDSFHPL----I-TRDEVLYVFPSDFCRSVYI-TFSD--FESV-RGLPALRYKVP-AEIL-ANTS----DNAG O_anatinus_ENSOANP00000002110 -----VN--YW------------R------S--DQC--NMING--TSGQMWAPF----M-TPKSSLEFYSPEACRSMKL-VYEQ--SRDF-NGIPTFRFVAP-KTLF-ANGTVYP-PNEG T_nigroviridis_ENSTNIP00000002999 -----LA--WW------------S------T--DEC--NMING--TTGASFHPV----V-TKGEKLYMFSSDLCRSLYA-VYEE--DVTV-KGIAAYRFSPP-SEVF-ANTT----ANAG T_rubripes_ENSTRUP00000047691 -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M-TEESTLPFYSPDACRSLEL-VYQR--SGKM-KGIPLYRFVAP-KTLF-ANGTDYS-PNEG T_nigroviridis_ENSTNIP00000010349 -----LT--FW------------K------S--NQS--NSING--SDGSAFHPL----L-TKDERIYIFTPDLCRSIYM-EFEK--DVTV-KGIPAYRFTPP-RSVF-ASKEENP-ANEG T_guttata_ENSTGUP00000005161 -----VN--YW------------R------S--NQC--NMING--TAGEMWPPF----L-SP-TFLDFYSPDACRSLRL-VYEQ--SGEF-KGVPTYRFVAP-KTLF-ANGTDYP-PNEG M_domestica_ENSMODP00000019581 -----LN--FW------------N------S--DQC--NMING--TSGQMWAPF----M-TPDYNLQFYSPEACRSLSF-KYEK--SGEF-KGIPTFRFVAP-DTLF-ANGSVYP-PNEG A_carolinensis_ENSACAP00000014578 -----VS--YW------------N------S--DQC--NMING--TSGELWPPF----R-TPSTPLEFYSPDACRSLTL-IYNQ--TREF-KNIPTYRYLAP-TTMF-ANGTDYP-PNEG C_familiaris_ENSCAFP00000012634 -----LD--WW------------T------T--DKC--NMING--TDGDSFHPL----I-DKDEILYVFPSEFCRSVYI-TFSD--FKSV-QGLPAFRYKVP-GEVL-ANTS----DNAG B_taurus_ENSBTAP00000018959 -----VN--YW------------H------S--DQC--NMING--TSGQMWAPF----M-TPESSLEFYSPEACRSMKL-VYKE--QGVF-GGIPTFRFVAP-STLF-ANGSVYP-PNEG T_rubripes_ENSTRUP00000036580 -----LS--FW------------N------S--NQS--NSING--SDGSAFHPL----L-TKDERIYIFTPDLCRSIYM-EFEK--DVEV-KGIAAYRFTPP-RSVL-ASKEENP-ANEG G_aculeatus_ENSGACP00000021517 -----LT--FW------------T------S--NQS--NSING--SDGSAFHPF----L-DKNERIYIFTPDLCRSIHM-EFEK--EVEV-KGIPAYRFTPP-RSVF-ASKEENP-ANEG R_norvegicus_ENSRNOP00000001301 -----VN--YW------------H------S--EQC--NMING--TAGQMWAPF----M-TPESSLEFFSPEACRSMKL-TYQE--SRVF-EGIPTYRFTAP-DTLF-ANGSVYP-PNEG P_pygmaeus_ENSPPYP00000005810 -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M-TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG M_musculus_ENSMUSP00000083242 -----ID--YW------------H------S--EQC--NMING--TSGQMWAPF----M-TPESSLEFFSPEACRSMKL-TYNE--SRVF-EGIPTYRFTAP-DTLF-ANGSVYP-PNEG D_rerio_ENSDARP00000076810 -----MS--FW------------K------T--NQS--NMING--TDGSAFHPF----L-TKEERLDVFTADLCRSIHM-RFEK--EVEV-KGIPAYRFTPP-RAVL-ASGTNNP-ENEG A_carolinensis_ENSACAP00000012360 -----LN--WW------------T------S--PDS--NMING--TDGSTFHPL----I-GTDEKIYVFSSDLCRSLYL-TFDE--YVTV-EGISAYRFVPP-VRLF-ANVSTNP-DNAG X_tropicalis_ENSXETP00000002583 -----VD--FW------------N------S--EQT--NMING--TAGQMWPPF----R-KPSEPLEFYSPDACRSMKL-VYEK--EEKF-RGIPTFRYTAP-NYLF-ANGSDYP-PNEG C_familiaris_ENSCAFP00000010357 -----VN--FW------------H------S--DQC--NMING--TSGQMWAPF----M-TPETSLEFYSPEACRSMKL-IYKE--SGTF-QGIPTYRFVAP-STLF-ANGSVYP-PNEG C_intestinalis_ENSCINP00000025688 -----LN--YW------------S------T--KEA--NMLNG--TDGVFMPPK----V-TDDDRLYIYTTDVCRSMYL-VFEK--DTEV-RSIATKRFHLP-AEVF-ANVTTNP-DNAG T_guttata_ENSTGUP00000016695 -----LS--YW-------------------K--GHC--DMVNG--TDGASFPPF----V-KKDQVLRFFSADICR--------------------------------------------- O_latipes_ENSORLP00000000458 -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I-NRNELLYIFAADLCRSIHL-AYVE--DVEV-KGIQAFRFAPP-EDVL-MSPKDNP-ANAG A_gambiae_AGAP004846-PB -----QT--HW------------L------S--EQC--NRLNG--TDGSIFPPR----I-TKNSTLHVYEKDLCRLLPL-SFEK--EVTVRGGVKGYRFTPS-PDVF-ASVDKNP-NNMC M_mulatta_ENSMMUP00000038414 -----VD--FW------------H------S--DQC--NMING--TAGQMWPPF----M-TPESSLEFYSPEACRSMKL-MYKE--PGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG D_melanogaster_FBpp0072308 -----LP--HW------------T------T--DAC--NTLAG--TDGSIFPPH----I-DHDRILHVYDKDLCRLLPL-VFEK--EVMTSNEVPGYRFTPP-EWVF-ADVDSHP-DNMC A_aegypti_AAEL000256-PA -----QT--HW------------L------S--EQC--NRLNG--TDGSIFPPH----I-TKNTTLHVYEKDLCRLLPL-SFEK--EVTVRNGVQGYRFSPA-PDVF-ASVDINK-DNMC E_caballus_ENSECAP00000021856 -----VS--FW------------H------S--DQC--NMING--TAGQMWAPF----M-SPESSLEFYSPEACRSMKL-VYKE--AALF-EGIPTYRFVAP-STLF-ANGSVYP-PNEG D_melanogaster_FBpp0110185 -----LQ--VW-----------LNASSEGET--SVC--NQING--TDASAYPPF----R-QRGDSMYIFSADICRSVQL-FYQT--DIQY-QGIPGYRYSIG-ENFI-NDIGPEH-DNEC D_rerio_ENSDARP00000089887 -----VD--YW------------R------S--DQC--NMING--TAGQMWPPF----M-TKETTMPFYSPDACRSFLL-FYSLFCPLYF-SSLPHYFFLVT-YHLF-SHVFCVPQPPSP A_gambiae_AGAP010133-PA -----TG--MY-------------------R--GKC--GEVYG--TSGELWPAS----S-NVPANITLFPSDICRSITL-QGRE--QVSL-YNIQGTKYVGD-DRVF-DNGVKYP-EASC D_melanogaster_FBpp0079088 -----TG--FF-------------------D--SYC--GMTNG--SAGEFQPQH----L-KPGDSVGLFTPDMCRTIPL-DYVE--TVDI-EGLEGYKFSGG-PRSV-DNGTQYP-ENLC A_gambiae_AGAP004845-PA -----LD--LW------------H------T--DEC--DRVGG--TDGSQFPPH----LMDRKHPLQVFIKSLCRKFPL-VYDS--EVTALDGIPAWRYKIP-NNVF-SHPDEHM-PNHC A_gambiae_AGAP005716-PA -----LD--VW------------NNRSSGLS--SSC--NKIHG--TDGSGYPPF----R-TGVERMTIFSTDICRTVDI-KLTG--SSSY-EGIPALRYEID-NNFL-HEIGPEY-GNDC A_aegypti_AAEL000227-PA -----LD--IW------------T------T--DEC--NRVDG--TDGSQFPPH----LMDKRQTLYVFIKSLCRKFPL-RYEK--EVTLFDGIPAWRYKAP-TDVF-AHPSINA-DNQC A_gambiae_AGAP003373-PA -----TD--FF-------------------E--GTC--GMLNG--SAGEFYPPG----L-SKERPIELFTPDMCRSLPL-DFEE--EVTI-HGLKAYKYSGD-RRAI-DNGTLYP-ETAC D_rerio_ENSDARP00000071723 -----LN--WW------------S------S--EEC--NMING--TDGASFHPI----I-TKADRLYIFSSDLCSSGIC-RVSD--VTFF---VPQINLVPL-NFSFIKEDNKNP-DNAG D_melanogaster_FBpp0077748 -----TG--FY-------------------E--MPC--GIVNG--TTGDMFPPK----M-NVNDEITIFATDACRFMNL-RPRG--TYEN-HGLTATKWVGT-EETL-DSGENYP-NQAC O_cuniculus_ENSOCUP00000002939 -----LD--WW------------A------T--DKC--NMING--TDGDSFHPL----I-TSDEVLYVFPSDLCRSVYI-TFSG--FESV-QGVPALRYKLP-AEIL-ANTS----ENAG C_intestinalis_ENSCINP00000011713 ----------------------------------------------------------------------DDVCRSMYL-VFEK--DTEV-RSIATKRFHLP-AEVF-ANVTTNP-DNAG A_gambiae_AGAP002738-PA -----LA--QW------------N------G--SHC--SNIRN-ASDGTKFKSF----I-EPDDQLLFFRKSMCRAQILIQNGT--DYEV-DGLKATKFVFE-ENAL-DNGEYDP-RNKC A_aegypti_AAEL009423-PA -----TG--MY-------------------R--GKC--GEVRG--TTGELWPVS----H-SLKSNVTIFASDVCRSLTL-QYGE--QITI-HDVEGNKYVGD-ERVF-DNGTMFP-EAAC D_melanogaster_FBpp0072303 -----LD--YW------------E------G--DEC--NRIDG--SEPSMFSPH----LLQDRSTVNVFLQVLCRKVPL-HFEK--EVTIYNDIDVLRYRTP-MDVF-SHPSKNP-ANQC A_gambiae_AGAP008179-PA -----TD--YY-------------------R--GEC--GRIRG--TTGEVWPPWGRTLT-GTPPSVSVFAPDVCSSVTL-EYAE--EMER-YGIDGLRWIGT-DRVF-DNGLHYP-ETEC A_gambiae_AGAP005725-PA -----LP--HW------------D------G--EPC--RSIQA--SEGSFFPPR----DITQKDTVYIYDKDLCRTLPL-VYRE--PVEK-DGISADLYTLA-EDAY-GPP--NE-NNSC G_aculeatus_ENSGACP00000018249 -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I-NRNELLYIFAADLCRSIHL-GYVK--DVEV-KGIQAYRFAPP-NDVL-MNPKENP-TNAG A_aegypti_AAEL009432-PA -----TG--FY-------------------R--DEC--GAVIG--TTGELWPPF----QERQFTNVTVFSPDICSAVTL-QYDG--TFRL-HGVEGLKWKGN-DRVF-DNGHHYS-ETAC G_gorilla_ENSGGOP00000006367 -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M-TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG D_melanogaster_FBpp0079175 -----TG--AF-------------------E--GTC--GQVHG--SMGEFFPPN----L-GTKDTVYMYMPKMCRAIPL-DYVE--TVTV-HGVTAYKFSGT-RHAV-DNGTLYP-DTRC D_melanogaster_FBpp0112038 -----LP--HW------------S------E--PPC--TSIAG--SEGSFFPPR----ELTKSEVVHIYDKDLCRIIPL-KYVE--SLEK-DGIAADLFRLP-NNSY-GDSAHNP-ENKC A_aegypti_AAEL011222-PA -----LA--QW------------E------G--DHC--SNIRN-ASDGTKFKSF----I-KDEEQLLFFRKSMCRAQRMVQTGS--NHEV-DGLQATKFVFE-ENAL-DNGQIDA-RNKC C_intestinalis_ENSCINP00000010908 -----LP--YW------------F------G--ETC--NMING--TDGTMTHPF----M-DKSKPTYFFIDEMCRSLHA-VYES--DFTV-EGIKGWKYSVP-PEIF-QSPLINE-DNSC C_elegans_C03F11.3 SIGNTLPPMWW---------PYANKTYCKDP--NSA--LVLTG--TNGDYFKNF----V-KKTDILPAFVSDVCRTIHF-VFDR--EVTV-KGFKGYRFVMP-PTQF-DYSLD---ENCG A_aegypti_AAEL005979-PA -----LP--HW------------D------K--EPC--SSIEA--SEGSFFPPR----EVTNSDVVYIYDKDLCRSLPL-VYRH--PVEK-DGIPADLYTLA-EDSY-GPP--NG-NNSC D_melanogaster_FBpp0110565 -----LP--QW------------D------G--DHC--SNIEF-ASDGTKFKSF----I-QPNETVKFFRKSMCRPINLYRVGN--EKTY-GSLKGYNYVFE-DNAF-DNGATNE-ANKC D_melanogaster_FBpp0080584 -----TG--WY-------------------D--GEC--GRLNG--STTDLFVPD----E-PKEKALTIFIPDTCRIINL-EFTG-QSETI-QGITGWKYEIT-PNTF-DNGQING-NAKC D_melanogaster_FBpp0079173 -----TE--AS----------------------PRC---KLKG--SAGEFHPIP----L-VKGRPISYFLPDLCRELQV-DYSG--TTIF-EGIDAFVYRGS-ARNM-ANGTDNP-DNSC D_melanogaster_FBpp0083430 -----QD--IW------------P------D--GEC--NTFVG--TDSTVFAPG----L-KKEDGLWAFTPDLCRSLGA-YYQH--KSSY-HGMPSMRYTLD----L-GDIRADE-KLHC C_elegans_Y76A2B.6 -----LDETWW------------S------T--DES--LKIKG--TDGSLFHPF----L-SKHEKLYVYVAELCRSIWL-EFKE--EVEY-RGLKAYRFVVP-PEVF---DVTHP-GNQG D_melanogaster_FBpp0082805 -----FK--GW------------QYNEETNG--TMC--NRIWG-SHDATLFPLD----M-DENDEFFLYRRTFCRRLPV-KFNR--TTTF-NGLDAFEFVME-PDSF-DSEVDNA-NSSC A_aegypti_AAEL002741-PA -----LA--HWGYVGKDHWDAERR------N--TPC--NTLQG-SYDGTVFPRN----I-SKTEVFKVYRKAFCRTLPI-AFER--EGMH-DGIKAYWFSIQ-ENAF-ESSLDDP-YTAC C_elegans_Y49E10.20.1 -----MPEGTW------------D------T--KYA--RMING--TDGQLFSPM----L-KREDRLTIFVPQICRSIQM-EYTK--DVAV-NGVPSWRYAPP-LDLY-DPALP---QNRA A_aegypti_AAEL008370-PA -----TN--FF-------------------A--DQC--GMLNG--SAGEFYPPN----L-SKDVPIQLFTPDMCRSLPL-DFEG--EEEV-AGIKGYKYAGG-PRTV-DNGTMFP-ETAC A_aegypti_AAEL005374-PA -----MD--IY------------D------G--DEC--NRYIG--TDSTIFPPF----L-TTKDKLWAWSPEICRSIGA-EYGG--KSKY-AGLPMSFFKLD----F-GDARNEP-EHHC D_melanogaster_FBpp0080585 -----TG--FY-------------------P--GEC--GKVNG--STGELWSPY----R-TWDQPTTIFLPDAARYLNL-FPKE--NLTI-DGIDVWRYEST-NLTI-DNGQLSP-DTEC A_gambiae_AGAP004643-PA ----------------EYYHDLIS------R--STT-EELIRS--YDGSVFPRN----I-SKTEVFKVYRKAFCRTLPI-AFER--EGEV-DGIKAYWFSIK-ENAF-ESSMDDP-YTSC A_aegypti_AAEL007748-PA -----AV--RT-------------------Q--GQC--GLYEG--FTGELFPTK----I-RHDQTLRIFLMELCRAVSF-EFER--EEEV-HGVLGYRFVAN-ERTM-DDV--------- A_gambiae_AGAP002451-PA -----MD--IW------------D------G--DEC--NQYIG--TDSTIFPPF----L-TAQDRLWAWSPEICRSLGA-HYVH--KSKY-AGLPMSYFELD----F-GDLKNEP-HNHC G_gorilla_ENSGGOP00000008199 -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I-TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG A_gambiae_AGAP010132-PA -----VP--NY-------------------R--GVC--GQVRG--SAGEVWPPMGRNLG-DNIRPLNLFLPDLCSAITL-RHER--EFTV-HGLDGELWVGD-ARNF-DNGHTIP-ETEC A_aegypti_AAEL009420-PA -----VP--HY-------------------R--GLC--GQVRG--STGSVNAPMTSAQT-RDPDDFVLFITDLCKAITL-KYDG--DFVL-NDLEGKVWVGD-DRVF-DNGHNFP-ETEC A_aegypti_AAEL000234-PA -----VP--GY------------I------PENGDCFASIVNS--SEGALYQQN----L-DENSVIIYWRRTLCRAVPL-YFER--KVQR-GPILGYEYVLP-DSSY-DRLTNV--SEDC C_intestinalis_ENSCINP00000027668 --------------------------------------NLVN------------------------------------------------------------------------------ A_gambiae_AGAP004847-PA -----VP--GF------------S------LAKGDCFASILNS--SEGATYPQN----L-DEQSVLIYWRKTLCRAVPL-YFER--RVQK-GPLTGYKYVLP-DNSY-DRLPDS--DADC A_gambiae_AGAP012849-PA -----VP--NY-------------------R--GVC--GQVRG--SAGEVWPPMGRNLG-DNIRPLNLFLPDLCSAITL-RHER--EFTV-HGLDGELWVGD-ARNF-DNGHTIP-ETEC C_elegans_F11C1.3 -----LP--WW------------K------T--EDT--SDLRG-TCDGTIQKPG----I-QKTDTVVQFQSFLCRKYNL-HYHE--SKTV-NSIPTYGFKVE-DDSY-DAI-----KNPG D_melanogaster_FBpp0072310 -----TR--QY------------D------S--NSCPFNVSGA--LDNSLFPPF----V-QPDTPLSIVAIESCRVLPL-TYQR--QERY-NGLDTFRYTLL------QSHQKPPG---- C_elegans_F07A5.3 -----LPGEWW------------T------T--PKA--RSIRG-SDSGSFTQMH----L-DESSTADMFFSFMCRSFTK-TFYQ--RETI-ESIPTIGYHIG-YDEW-DTTSD---NNVG C_elegans_R07B1.3 -----LPASFW------------P------T--LEA--RQIKG-PDSGSLSKIH----L-TKTDELPFFLSFMCRSFKR-TYWQ--DGLV-DGIKTMAFAVP-YEEF-DTTLE---KNAG A_gambiae_AGAP000016-PA -----PA--AH-------------------GEFHPC--DGFAG--LTGEFFPSR----I-ERDQAIVIVLPELCRRLTL-EFDR--EQLV-AGIMGFRYAVRLVRPF-RSAQMSE-SNMQ 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 F--------------------------------CTEK----------VISNNC--TSYGVLDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIEGLH-PNEDEHR-TYLDVEPIT-- R_norvegicus_ENSRNOP00000008319 F--------------------------------CTEK----------VISNNC--TSYGVLDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIEGLN-PNEDEHR-TYLDVEPIT-- R_norvegicus_ENSRNOP00000058398 F--------------------------------CTEK----------VISNNC--TSYGVLDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIQGLN-PNEDEHR-TYLDVEPIT-- C_familiaris_ENSCAFP00000009599 F--------------------------------CTEK----------VISNNC--TSYGVLDIGKC--KE---GK-PVYISLPHFLHASPDIGEPIEGLS-PNEDEHT-TYLDVEPIT-- P_pygmaeus_ENSPPYP00000020018 F--------------------------------CTEK----------IISKNC--TSYGVLDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- P_troglodytes_ENSPTRP00000033093 F--------------------------------CTEK----------IISKNC--TSYGVLDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- B_taurus_ENSBTAP00000023750 F--------------------------------CTEK----------IISKNC--TLYGVLDIGKC--KE---GK-PVYISLPHFLHGSPELAEPIESLS-PNEEEHS-TYLDVEPIT-- H_sapiens_ENSP00000308165 F--------------------------------CTEK----------IISKNC--TSYGVLDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- E_caballus_ENSECAP00000013084 F--------------------------------CTEK----------IVSKNC--TLYGVLNIAKC--KD---GR-PVYISLPHFLHASPEILESFEGLN-PNEEEHS-TYLDVEPIT-- M_domestica_ENSMODP00000021313 F--------------------------------CTEK----------IISKNC--TSAGVLDISTC--KD---RK-PVYISLPHFLHASPDVPEPIEGLN-PNEEEHR-TYLDVEPIT-- B_taurus_ENSBTAP00000018902 F--------------------------------CTEK----------IISKGC--TLYGVLDISKC--KE---GK-PVYISLPHFLHASPEIAELIEGLS-PNEEEHS-TYLDVEPIT-- O_anatinus_ENSOANP00000005521 F--------------------------------CTEK----------VISRNC--TSAGVLDISSC--KQ---KK-PVYISLPHFLHASLDVTDPVEGLS-PNQEEHQ-TYLDVEPIT-- G_gallus_ENSGALP00000013734 F--------------------------------CTDQ----------VISQNC--TLAGVLDISSC--KA---GR-PVYISLPHFLHASESILHDVEGLS-PNEEEHE-TFLDVEPTT-- O_cuniculus_ENSOCUP00000002156 F--------------------------------CTET----------IISNNC--TSYGVLDIGKC--KE---GR-PVYIKMHHFLHASPDVSEPIEGLN-PNEEEHR-TFLDVEPXX-- T_guttata_ENSTGUP00000002704 F--------------------------------CTDP----------ELSENC--TIAGLLDISAC--KA---KR-PVYISLPHFLHASESVLHSVEGMS-PNEQEHE-TYLDIEPVT-- A_carolinensis_ENSACAP00000015615 F--------------------------------CTEQ----------IISRNC--TGAGALDISAC--KE---GK-PVYISLPHFLYASEEVFLGVEGLQ-PNPKEHM-TYLDVEPTT-- X_tropicalis_ENSXETP00000017231 F--------------------------------CKDF----------QLSRNC--TAAGVLDLRSC--QG---GK-PIFLSLPHFLYASDYLLDSVSGLK-PNKEEHE-TYIDVEPIT-- T_rubripes_ENSTRUP00000041076 F--------------------------------CRDQ----------KVTKNC--SLAGALDISSC--QS---GK-PIYISLPHFLYGSPILQSNVLGLN-PSEEHHM-TYMDVEPIT-- D_rerio_ENSDARP00000050752 Y--------------------------------CTDH----------EITRNC--TLAGLLDITSC--K----GT-PVFISLPHFLYASIELQQGVVGMN-PNLDEHS-IFLDVEPIT-- O_latipes_ENSORLP00000020106 F--------------------------------CKNM----------QTTKNC--TLAGVLELSVC--QQEI-GA-PVYISLPHFLLGSDILRESVVGLN-PHPENHK-TFLDVEPIT-- T_nigroviridis_ENSTNIP00000014345 F--------------------------------CRDT----------QVTRNC--TLAGALDISSC--QD---GK-PVYISLPHFLHGSAVLQQNVLGLH-PSPEHHM-TYLDVEPTT-- G_aculeatus_ENSGACP00000026365 F--------------------------------CKNQ----------KTTRNC--TLAGVLDISTC--QD---GK-PIFISLPHFLYGSEYLREDVKGLH-PNKEHHD-TFLDVEPTT-- G_gorilla_ENSGGOP00000005986 X--------------------------------XXXX----------XXXXXX--XXXXXXXXXXX--XX---XR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- X_tropicalis_ENSXETP00000017237 F--------------------------------CKDM----------KVTRNC--TADGILELRAC--RD---RK-PIFLSLPHFLHGSQFLLDAVGGLK-PNEYEHR-SYIDVEPVS-- T_guttata_ENSTGUP00000001744 F--------------------------------CVP-------------AGNC--PGTGVLNVSVC--KQ---GA-PIFLSAPHFYQADPKFVEDIEGMH-PRKEYHE-TFLDINPLT-- X_tropicalis_ENSXETP00000052043 F--------------------------------CVP-------------EGNC--LPSGLLNVSIC--KE---GA-PIVLSSPHFYQADENVINSIRGMK-PVKEHHM-TFLDLNPLT-- M_mulatta_ENSMMUP00000027514 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNKEDHE-TFVDINPLT-- G_gallus_ENSGALP00000018715 F--------------------------------CVP-------------PGNC--PGAGVLNVSIC--KQ---GA-PIFLSAPHFYQADQKFVSDIEGMH-PTKEYHE-TFVDINPLT-- G_aculeatus_ENSGACP00000022821 F--------------------------------CVP-------------IGNC--LGSGVLNVSPC--KQ---GA-PIVMSSPHFYQADEKYVQGVFGMR-PQKEQHQ-TVIDINPFT-- H_sapiens_ENSP00000264896 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNQEDHE-TFVDINPLT-- O_latipes_ENSORLP00000012225 F--------------------------------CVP-------------AGNC--LGSGLLNVSAC--KQ---GA-PIIMSSPHFYQADAKYVQSVFGMK-PVKEQHE-TTIDVHPLT-- O_anatinus_ENSOANP00000014317 F--------------------------------CGP-------------QGRC--LGSGVLNVSVC--KD---GV-PIFLSAPHFYQADEQFVAAVKGLR-PEKASHE-TFLDIDPVT-- P_troglodytes_ENSPTRP00000027814 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNKEDHE-TFVDINPLT-- M_domestica_ENSMODP00000037525 F--------------------------------CNP-------------SGNC--LGSGVLNISVC--KN---GA-PIFLSSPHFYQADKKFISAIRGMN-PNKEDHE-TFLDINPLT-- P_pygmaeus_ENSPPYP00000016592 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PKKEDHE-TFVDINPLT-- T_rubripes_ENSTRUP00000042953 F--------------------------------CVP-------------AGDC--LGTGVLKVSVC--RE---GA-PIVVSFPHFYQADPMYINAIDGLS-PNKDEHE-TYLDLQPTS-- R_norvegicus_ENSRNOP00000003052 F--------------------------------CIP-------------EGNC--MDAGVLNVSIC--KN---GA-PIIMSFPHFYQADEKFVSAIKGMR-PNKEEHE-SFVDINPLT-- O_latipes_ENSORLP00000001610 F--------------------------------C-----------------PC--RQSGLLNVSSC--RH---NS-PVFISHPHFFNADPVLQDYVLGLN-PTEEEHG-LFIDIHPLT-- D_rerio_ENSDARP00000023056 F--------------------------------CVP-------------AGDC--LGKGVLKVSVC--RQ---GA-PIVVSFPHFYQADERYINAIEGMN-PNEEEHE-TYLDINPTT-- P_troglodytes_ENSPTRP00000009553 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- H_sapiens_ENSP00000261693 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- M_musculus_ENSMUSP00000031377 F--------------------------------CIP-------------EGNC--MDSGVLNISIC--KN---GA-PIIMSFPHFYQADEKFVSAIKGMH-PNKEEHE-SFVDINPLT-- O_latipes_ENSORLP00000008151 F--------------------------------CVS-------------KKEC--LGTGVLKVSPC--RK---GA-PVVASFPHFYLAEDKYVDAIEGMS-PDREHHQ-TYLDLNPTT-- T_nigroviridis_ENSTNIP00000018658 F--------------------------------CVP-------------AGDC--LGTGVLKVSVC--RE---GA-PIVVSFPHFYQADPMYINAIDGLS-PNKEEHE-TYLDLQPTT-- G_gallus_ENSGALP00000004761 F--------------------------------C-----------------PC--RQSGIQNVSSC--RL---NA-PMFISHPHFYNADPSLVDAVEGLH-PSREEHA-LFLDVHPVT-- T_rubripes_ENSTRUP00000019814 F--------------------------------CVP-------------LGNC--PGSGLLDVSTC--KQ---GA-PIVLSSPHFYQAEEKFVEAVFGMK-PNKEQHQ-TTIDVNPLT-- B_taurus_ENSBTAP00000014549 F--------------------------------CIP-------------KGNC--LGSGVLNVSVC--KN---GA-PIIMSFPHFYQADEKFVSAIGGMH-PNKEYHE-TFVDINPLT-- T_nigroviridis_ENSTNIP00000016587 F--------------------------------C-----------------PC--RQSGLLNVSSC--RH---NS-PVFISHPHFFNADPVLQDYVQGLS-PNEEEHG-LFIDIHPQT-- E_caballus_ENSECAP00000022283 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---GA-PIVMSFPHFYQADEKFVSAIDGMH-PNKDYHE-TFVDINPLT-- O_anatinus_ENSOANP00000002110 F--------------------------------C-----------------PC--LQTGIQNVSTC--RF---SA-PLFLSHPHFYNADPVLVEAVNGLH-PNKEQHS-LFLDIHPVT-- T_nigroviridis_ENSTNIP00000002999 F--------------------------------CVP-------------PGNC--PGSGLLDVRVC--KS---GA-PIVMSSPHFYQAEEKFKEAVFGMR-PDKQLHQ-TAIDIHPLT-- T_rubripes_ENSTRUP00000047691 F--------------------------------C-----------------PC--RQSGLLNVSSC--RQ---NS-PVFISHPHFFNADPVLLDYVHGLS-PNEEDHG-LFIDIHPLT-- T_nigroviridis_ENSTNIP00000010349 F--------------------------------CLS-------------PKEC--LGTGLLKVSPC--RK---GA-PVVASFPHFHLADEKYVNAIKGMS-PQLEHHQ-TFLDLNPTT-- T_guttata_ENSTGUP00000005161 F--------------------------------C-----------------PC--MQSGILNVSTC--RL---NA-PMFISHPHFYNADPSLVNAVEGLR-PNKDQHG-LFLDLHPMT-- M_domestica_ENSMODP00000019581 F--------------------------------C-----------------PC--LESGIQNMSAC--QL---NA-PMFLSQPHFFNADPVLVESVTGLH-PNKDEHS-LFLEVHPVT-- A_carolinensis_ENSACAP00000014578 F--------------------------------C-----------------PC--LQSGIQNVSSC--RL---NA-PVFLSHPHFFNADPALLEAVGGLH-PNKEEHE-LFLDLHPMT-- C_familiaris_ENSCAFP00000012634 F--------------------------------CVP-------------KGNC--LGSGVLNISIC--KNGNSGA-PIIISFPHFYEADKKFVSAIDGMR-PNKDYHE-TFVDINPLT-- B_taurus_ENSBTAP00000018959 F--------------------------------C-----------------PC--RESGIQNVSTC--RF---NA-PLFLSHPHFYNADPVLAEAVSGLH-PNPKEHS-LFLDIHPVT-- T_rubripes_ENSTRUP00000036580 F--------------------------------CVS-------------PKEC--LGTGLLKVSPC--RK---GA-PVVASFPHFHLADEKYVDAIKGMS-PQREHHQ-TFLDLNPTT-- G_aculeatus_ENSGACP00000021517 F--------------------------------CVS-------------PKEC--LGTGLLKVSPC--RK---GA-PVVASFPHFYLADKKYVAAIGGMS-PKREHHQ-TYLDLNPTT-- R_norvegicus_ENSRNOP00000001301 F--------------------------------C-----------------PC--RESGIQNVSTC--RF---GA-PLFLSQPHFYNADPVLSEAVLGLN-PDPKEHS-LFLDIHPVT-- P_pygmaeus_ENSPPYP00000005810 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- M_musculus_ENSMUSP00000083242 F--------------------------------C-----------------PC--RESGIQNVSTC--RF---GA-PLFLSHPHFYNADPVLSEAVLGLN-PNPKEHS-LFLDIHPVT-- D_rerio_ENSDARP00000076810 F--------------------------------CLT-------------PKKC--LDDGVLDVSVC--RQ---GA-PVVVSFPHFHLGDEKYVQAVEGLS-PVHEQHQ-TFLDLNPTM-- A_carolinensis_ENSACAP00000012360 F--------------------------------CVP-------------AGNC--LGAGLLNVTAC--KQ---GA-PIFLSPPHFYLSDEKYANAIDGMH-PNKENHE-IFLDINPFS-- X_tropicalis_ENSXETP00000002583 F--------------------------------C-----------------PC--VASGVQNVSAC--RF---NA-PLFLSFPHFYNADPGFLESVEGLH-PTEELHS-LFLDMHPLT-- C_familiaris_ENSCAFP00000010357 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---NA-PLFLSHPHFYNADPMLAEAVLGLH-PNQEEHS-LFLDIHPVT-- C_intestinalis_ENSCINP00000025688 F--------------------------------CVP-------------AGNC--LDAGVLSLAPC--KQ---GA-PVIISSPHFYLGAEKYINGVNGLH-PNKNEHE-TILDIEPMS-- T_guttata_ENSTGUP00000016695 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000458 F--------------------------------CVP-------------AGDC--LGTGVLKVSVC--RE---GA-PIVVSFPHFYQADPKYINAVEGMN-PNKDEHE-TYLDLQPTT-- A_gambiae_AGAP004846-PB Y--------------------------------CPA-------------GPPC--APHGLFNVSLC--QY---DS-PILLSFPHFYMADQTLRTAVEGISPPEKDKHQ-LFIDVQPDM-- M_mulatta_ENSMMUP00000038414 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- D_melanogaster_FBpp0072308 F--------------------------------CPAG------------KPSC--SPNGLFNVSLC--QY---DS-PIMLSFPHFYLADESLRTQVEGISPPMKEKHQ-FFFDVQPKM-- A_aegypti_AAEL000256-PA Y--------------------------------CPA-------------GPPC--APNGMFNVSLC--QY---DS-PILLSFPHFYLADQSLRNAVEGISPPEKEKHQ-LFIDVQPEM-- E_caballus_ENSECAP00000021856 F--------------------------------C-----------------PC--RESGIQNVSTC--RF---SA-PLFLSHPHFYNADPVLAEAVAGLH-PNPEEHA-LFLDIHPVT-- D_melanogaster_FBpp0110185 F--------------------------------CVDK-----LANVIKRKNGC--LYAGALDLTTC---L---DA-PVILTLPHMLGASNEYRKMIRGLK-PDAKKHQ-TFVDVQSLT-- D_rerio_ENSDARP00000089887 F--------------------------------F-----------------TT--TNSSLLVFSLT--IS---GS-PTFISQPHFYNADPQLLDTVSGLS-PSEDEHG-LFIDIHPET-- A_gambiae_AGAP010133-PA W--------------------------------CNSN------------PTQCPDLKPGVFNASAC--KY---GS-PTFVSFPHFYLADESYQTAVTGLR-PNQTEHE-FYMAIEPST-- D_melanogaster_FBpp0079088 F--------------------------------CG---------------GQC--VPSGVMNISSC--RF---GS-PVFMSYPHFFNADPYYPDQVEGLS-PNQKDHE-FYMVVQPST-- A_gambiae_AGAP004845-PA F--------------------------------CHLE------------SGSC--PPSGLFNITGC--SM---GA-PIFASFPHFYTGDRKLIESIEGVN-PVQEKHE-TYADIHPRL-- A_gambiae_AGAP005716-PA Y--------------------------------CVNK-----IPKSIVKSNGC--LYKGALDLSNC---F---DA-PVVLTLPHMLGVAEEYTALIDGMD-PEPERHQ-IFVDVEPYT-- A_aegypti_AAEL000227-PA F--------------------------------CHLG------------SASC--PLSGLLNATLC--SY---GA-PIYASFPHFYTGDRKLLEMVEGLD-PQREKHE-TFADIHPRL-- A_gambiae_AGAP003373-PA F--------------------------------SA---------------GEI--VPSGVLNISSC--RF---GT-PVFVSFPHYYGADPFYLDQVEGLS-PSKDKHQ-FYMSMEPTT-- D_rerio_ENSDARP00000071723 F--------------------------------CVP-------------PGHC--LGSGLLNASVCCVFS---GA-PIIMSSPHFYQADQKFVDDIWGMK-PIKEEHQ-TFADINPLT-- D_melanogaster_FBpp0077748 F--------------------------------CDEA-----------RFDEC--PKTGVVECKAC--RD---KA-PIYSSFPHFYLADQSYVDAVSGMK-PEKEKHE-FFLAVEPIT-- O_cuniculus_ENSOCUP00000002939 F--------------------------------CLP-------------QGNC--LGSGVLNASIC--KD---GA-PIIMSFPHFYQADERFVSAIGGMH-PNKEDHE-TFVDINPLT-- C_intestinalis_ENSCINP00000011713 F--------------------------------CVP-------------AGNC--LDAGVLSLAPC--KQ---GA-PVIISSPHFYLGAEKYINGVNGLH-PNKNEHE-TILDIEPMS-- A_gambiae_AGAP002738-PA Y--------------------------------CR--------------KGNC--LPRGLIDVTSC--YY---GF-PIALSYPHFLDADPKVRSHVNGSR-PDPTAHR-SHFMINPIS-- A_aegypti_AAEL009423-PA W--------------------------------CNSD--------------YCPDVKSGVFNASAC--KF---GS-PTFVSYPHFYLADPSYLDVVSGLS-PNKSKHQ-FYIAMEPHT-- D_melanogaster_FBpp0072303 Y--------------------------------CQN-------------TELC--LPSGVINATKC--YG---DA-PIFPSFPHFFTGDPVLYQDFEGIE-PDAAVHQ-TYADIHPRF-- A_gambiae_AGAP008179-PA Q--------------------------------CTAE-----------DVADCPLLDNGAMDVSRC--KF---GA-PATVSYPHFYLANESYLKGISGMQ-PNEKEHR-FEMELEPYT-- A_gambiae_AGAP005725-PA F--------------------------------DH--------------SHYK--KYYGLQNISPC--QY---GA-PVYISNPHFYQSDPQLLDAVEGLE-PNAEQHK-TYFKIQPKL-- G_aculeatus_ENSGACP00000018249 F--------------------------------CVP-------------AGDC--LSTGVLKVSVC--RE---GK-RFFSPPPPPPPWGARMSAPVPPPP-PPPKKSP-FRPQPSPPC-- A_aegypti_AAEL009432-PA Q--------------------------------CTAP------------KEECPFLEYGALDVSSC--KM---GA-PATVSFPHFYLANNSSLDAVEGLN-PNKEEHE-FMMALEPYT-- G_gorilla_ENSGGOP00000006367 F--------------------------------C-----------------PC--LESGIQNVSTC--RF---XX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXVT-- D_melanogaster_FBpp0079175 Y--------------------------------CV--------------GGKC--MPSGVINIGPC--SF---NA-SVYMSFPHFYMADPSYLEAIEGLR-PEREKHE-FFMALEPNA-- D_melanogaster_FBpp0112038 Y--------------------------------DT--------------SEYE--PIQGLQNISPC--QY---GA-PVYISNPHFFESHPDLLNSVEGLK-PEREKHE-TYFKIQPKL-- A_aegypti_AAEL011222-PA F--------------------------------CR--------------KGQC--LARGLIDVTDC--YY---GF-PIALSYPHFHDSDPSLLTKVIGLH-PNESLHS-SFFMINAVS-- C_intestinalis_ENSCINP00000010908 F--------------------------------CADL-----------NHTVC--QHSGAILVSSC--YY---GV-PLLVSLPHFLYEDGFYSEKLVGMN-PKKELHE-MVLVYEPTT-- C_elegans_C03F11.3 Y--------------------------------CIPL---KYGSYEYPAQSAC--LPSGLLDISQC---T---GG-PIIMSKPHFYQASKVVSKFVPRFK-PTYDNDE-TMLDIEPNT-- A_aegypti_AAEL005979-PA Y--------------------------------EH--------------TDYK--PYRGLQNISPC--QY---GA-PVYISNPHFYQSDPQLLDAVEGLN-PQRDAHE-TFFKIQPKL-- D_melanogaster_FBpp0110565 F--------------------------------CR--------------KGDC--QPVGLIDVTDC--YY---GF-PISLSFPHFMNGDVGLQQNVTGIS-PDPDKHS-STFVIQPES-- D_melanogaster_FBpp0080584 W--------------------------------CPLE----------RQPDNC--PATGATDLGPC--AD---GV-PMYLSADHFMYADESYGSTISGYN-PNYDQNN-FYIIMERKM-- D_melanogaster_FBpp0079173 Y--------------------------------CQ---------------DNCQEVRSGLLNISSC--WY---GT-PVFASYPHFFKADPYYGEQVEGMK-PDKDRHE-MVIMLEPKT-- D_melanogaster_FBpp0083430 F--------------------------------CEDP----------EDLDTC--PPKGTMNLAAC---V---GG-PLMASMPHFYLGDPKLVADVDGLN-PNEKDHA-VYIDFELMS-- C_elegans_Y76A2B.6 F--------------------------------CNPS--EKQFYESQNDSSNC--MPKGLLEISKC--QQ---SQPPITISLPNFLFAPSEVRGSVKGLN-ETDEIRDSIVVDIEPRV-- D_melanogaster_FBpp0082805 Y--------------------------------CK--------------NNRC--LKKGVGNVSPC--YY---NI-PLAITYPHFMHADPSLLEPFDGLQ-PNVSRFT-STFVVQPQL-- A_aegypti_AAEL002741-PA Y--------------------------------CR--------------NGHC--LPKGLGDLSPC--WY---NI-PVAVSLPHFYKGDPALSQAIEGLK-PQKELHD-AIIIMQPQL-- C_elegans_Y49E10.20.1 F--------------------------------CNKNGMPRYFDNTTVQIENC--LPAGLIDLSRC--QA---GNPRVYLSNPHFYNSPMELWHSVTGLSVPTASNDL-TVVDIEPTA-- A_aegypti_AAEL008370-PA F--------------------------------NA---------------GEI--VPSGVLNISAC--RF---GT-PVFMSFPHFYGADEFYLNQVEGLN-PDKSKHQ-FYMTMEPTT-- A_aegypti_AAEL005374-PA F--------------------------------CRDP------------PDIC--PPKGTIDLAPC---L---GA-PIIGSKPHFYDSDPKLLAAVDGLT-PNEKDHD-VYIHFQLLS-- D_melanogaster_FBpp0080585 F--------------------------------CLKN-------------REC--PRNGVLDYGPP--AF---NG-PFYMSHPHFFLTDQMYRENTTGLQ-PEESEHG-MYVIMEPTL-- A_gambiae_AGAP004643-PA Y--------------------------------CK--------------NNRC--LPKGLGDLSPC--WY---NI-PVAVSLPHFYKGDPSLSQAIDGLS-PNKEKHD-AVIIMQPQL-- A_aegypti_AAEL007748-PA ---------------------------------CIED-------------REE--LPRGAINMTQC--KD---GA-PLFASFPHFYSADEYYRGAIEGMS-PDNEKHQ-TFVTIEPKT-- A_gambiae_AGAP002451-PA F--------------------------------CRDA------------PDDC--PPKGTMDLSPC---L---GG-PIIGSKPHFYGADPKLVEAVDGLA-PNKAAHD-VYIHFELASIC G_gorilla_ENSGGOP00000008199 F--------------------------------CIP-------------EGNC--LGSGVLNVSIC--KN---XX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXXX-- A_gambiae_AGAP010132-PA Q--------------------------------CTSP------------IDQCPFYRPGVLDVSEC--KF---GA-PLVVSYPHFYLAHPSYRTAVTGME-PDRAKHE-FRFALHPFS-- A_aegypti_AAEL009420-PA Q--------------------------------CTAP------------QDQCPVLKPGLLDVSGC--KF---GA-PLKVSFPHFYLADPSYLNAVTGLS-PMPQSHQ-FRYALHPFS-- A_aegypti_AAEL000234-PA Y--------------------------------KG--------------QNDF--LENGMTDMSKC--YN---GF-PIAATSPHYYARNFTMANKISGMQ-PNREKHY-SYTIAEPTL-- C_intestinalis_ENSCINP00000027668 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004847-PA Y--------------------------------KG--------------QFGL--LEDGMTDTSKC--SH---DV-PIVATSPHFYARNFSNAHKITGMI-PDRENQH-SYAIVDPSF-- A_gambiae_AGAP012849-PA Q--------------------------------CTSP------------IDQCPFYRPGVLDVSEC--KF---GA-PLVVSYPHFYLAHPSYRTAVTGME-PDRAKHE-FRFALHPFS-- C_elegans_F11C1.3 YRYENFEKVNYFPNWPCGLNHTKQNNGNCALVDCNQYDNFCNACCDGSHVNGTYVMPPGMVP-QRCLPGQMVPTPFGAILSAPHFYGAPKVVTESMVGIH-PDPELHRPGTFYINPAT-- D_melanogaster_FBpp0072310 ---------------------------------CLDT-----------SYGVK--LPDGMFDVSQC--VI---NDAPSAFSMPHFYGSSYNWSQHYEGYT-PNAEDHE-PYILLEPVT-- C_elegans_F07A5.3 FRYRNIEKRNYFPDWP--KCPPKGQCHQSGSIDCSKSINFCHACCDGSLYNGTYLLPPGMFPL-VCYPGRLQPTPFAVVYSPPHFLFSPDEVRTTVVGMA-PNKSLHEPMIYYHEPYS-- C_elegans_R07B1.3 FRYKNQENVDYFPDW------------------CDKNTTTSLSQCQKT-ANGTFLLPPGIFPL-VCYPGHNAQPPFTVLVSPPHFLYSPPEVQHHLSGMN-PDPEKHKPMVFHQEKTS-- A_gambiae_AGAP000016-PA S--------------------------------CPDT------------SIRL--GRYGILNTNEC---N---GF-PL-------YESDQAHVSSNESTS-FSSDSDL-LYYLLEPTT-- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 -GFT-LQFA-KRLQVNILVKPARKIE---AL-KNL--KRPYIVPILWLNE---TGTIGDEKAEMFKTQVTGKIKLLGMVEM--ALLGIGVVMFVAFMISYC-----------------AC R_norvegicus_ENSRNOP00000008319 -GFT-LQFA-KRLQVNILVKPARKIE---AL-KNL--KRPYIVPILWLNE---TGTIGDEKAEMFRNQVTGKIKLLGLVEM--VLLGVGVVMFVAFMISYC-----------------AC R_norvegicus_ENSRNOP00000058398 -GFT-LQFA-KRLQVNILVKPARKIE---AL-RNL--KRPYIVPILWLNE---TGTIGDEKVEIFRNQVTGKINLLDLVER--VLLVVGVLMFVAFMISYC-----------------AC C_familiaris_ENSCAFP00000009599 -GFT-LRFA-KRLQINILVKPAKKIE---AL-KNL--KRNYIVPILWLNE---TGTIGDEKAAQFRKQVTGKINLLGLVEI--ILLTVGVVMFVAFMISYC-----------------AC P_pygmaeus_ENSPPYP00000020018 -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDEKANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC P_troglodytes_ENSPTRP00000033093 -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDEKANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC B_taurus_ENSBTAP00000023750 -GFT-LRFA-KRLQVNMLVKPAKKIE---AL-KNL--KHNYIVPILWLNE---TGTIGDEKAEMFRNQVTGKINLLGLVEI--VLLSVGVVMFIAFMISYC-----------------AC H_sapiens_ENSP00000308165 -GFT-LQFA-KRLQVNLLVKPSEKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDEKANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC E_caballus_ENSECAP00000013084 -GFT-LQFA-KRLQVNILVKPSRKIE---AL-KSL--KRNYIVPILWLNE---TGTIGDEKAKMFRKQVTGKISLLGLVEM--VLLSVGVVMFVAFMISYC-----------------VC M_domestica_ENSMODP00000021313 -GFT-LQFA-KRLQVNILVKPVKKID---TL-SKL--KRNYLIPILWLNE---TGTIGDEKAEMFRKQVTGKISLLGLVEM--VLLTVGIVTFVASMIAYC-----------------VC B_taurus_ENSBTAP00000018902 -GFT-LQFA-QRMQINILVKPAKNIV---AL-KDL--KHNYLVPILWLNE---TATIADEKAEIFRNQVTGKINLLGLIEM--ILMSVGAVMFIAFTISYC-----------------AC O_anatinus_ENSOANP00000005521 -GFT-LAFA-KRLQVNLLISPAPLIE---PL-SKL--KRSYITPVLWLNE---TGTIGDEKAELFRAQVIGKINLLGLLQL--VLLILGLATFVSFTIAYC-----------------AC G_gallus_ENSGALP00000013734 -GFT-LQFA-KRLQVNLLVTPSSKIE---AL-SKV--QKPYVFPILWLNE---SAVIGDEKAEMFRNKVTGRVQLLGVVQM--VLIIAGSVLFLAFMGSYF-----------------IC O_cuniculus_ENSOCUP00000002156 -XXX-XXXX-XXXXXXXXXXXXXXXX---AL-KNL--TKNYIVPILWLNE---TGTIGDEKAEMFRKQVTGKINLLGLVEI--ILLSVGVVMFVAFMISYC-----------------AC T_guttata_ENSTGUP00000002704 -GFT-LRFA-KRLQVNLLVRPSTRIE---PL-KKV--KKPYVFPILWLNE---SAVIGDEKAEMFRTKISSRLELLSMLQM--ALMIGGSVLFLAFMGSYF-----------------IC A_carolinensis_ENSACAP00000015615 -GFT-LQFA-KRLQVNLLVKPSAKIT---PL-QKI--KEAYLFPILWLNE---TAVIDDKKAEFFRSKVTNKIRLLYLVEA--VLIVVGAVMFLGFMAAYL-----------------IC X_tropicalis_ENSXETP00000017231 -GFT-MHFA-KRLQVNVMIQPTDKIE---VM-SKL--QSELVFPVAWLNE---TALIGDDSANMFKSKVTTPMKVVEILRI--VLLCVGSVVFLACSITLC-----------------VR T_rubripes_ENSTRUP00000041076 -GFT-LGFA-KRIQMNMMYGPSQKVK---IF-KKI--KDYTIFPIAWLNE---TAVLDQETADMFKEQLISRIRMLEMLQY--SLLGIGVSVFVLCLIGFC-----------------VV D_rerio_ENSDARP00000050752 -GFT-LRFS-KRLQVNMMYGPSDDIA---LL-NKI--KEHTIIPILWLNE---TAVLDDETAKMFKNELISRMDMLEGLQI--GLLVTGSAIFLGCMIGLI-----------------VV O_latipes_ENSORLP00000020106 -GFT-LNFA-KRIQVNMILSHDPDYP---LV-SSLMLSYYMILPVVWMNE---TATLDDETADMFKNELLGRINMLDIIQK--VLLGAGAAIFVLCLIFYC-----------------FA T_nigroviridis_ENSTNIP00000014345 -GFT-LSFA-KRIQMNMMYGPSQRIT---VL-KKV--KDFTIFPILWLNE---TAELDQETADMFQQQLFSRVRLLEAVQY--SLLGVGLAAFFLCLVGVL-----------------VA G_aculeatus_ENSGACP00000026365 -GFT-LRFA-KRIQVNMM-----------VL-QKV--RDYTIFPLLWMNE---TAALDDETAAMIKGELFSRIDMLDILWK--ALLGSGVAVFLVCSISYC-----------------MV G_gorilla_ENSGGOP00000005986 -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDEKANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC X_tropicalis_ENSXETP00000017237 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001744 -GLV-LRAA-KRMQVNVHVRKLPEFF---ET-GNI--R-TLIFPVMYINE---SVLIDEASASKLRH-VLLEASVVTGIPF--VIMALGIVFGIVFIVLVC-----------------RS X_tropicalis_ENSXETP00000052043 -GTL-IQAA-KRMQVNVYVRKINVYP---IT-QDI--Q-TLFFPVMHLNE---SVLIDDKSAGRLRS-ILFQGRVVANIPF--IIMGLGIILAFLFTTLSC-----------------LQ M_mulatta_ENSMMUP00000027514 -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVLIDKETASRLKS-VINTTLIITNIPY--IIMALGVFFGFVFTWLAC-----------------KG G_gallus_ENSGALP00000018715 -GLV-LQAA-KRMQINIHVRKLPEFF---ET-GNI--R-TLIFPVMYINE---SVLIDEASANKLKH-VLLEASVVTGIPF--VIMAIGIVFGIVFSVLVC-----------------RA G_aculeatus_ENSGACP00000022821 -GII-VQAA-KRLQINVFVEKIPGFS---ET-GNA--R-TVLIPVVYLNE---SALIDDASAAKLHK-IIVQQNVVVNIPF--LFIGLAIILGGVFMFLMC-----------------RQ H_sapiens_ENSP00000264896 -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKETASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG O_latipes_ENSORLP00000012225 -GFL-LQAA-KRLQINVYVEQIETFS---QT-GNV--R-TLIFPVVYLNEEHQSVLIDDASVQKLHV-VVVEKNVLENIPF--ILIGLGILLGGIFMIAMC-----------------RQ O_anatinus_ENSOANP00000014317 -GMI-LRAA-KRFQVNVFVQQIDGFI---ET-GNI--K-TTLFPVMYLNE---SVLIDEDSVKKLRS-VLNTMMVITNIPY--IIMALGAFLGLLFTWMAC-----------------RG P_troglodytes_ENSPTRP00000027814 -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKETASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG M_domestica_ENSMODP00000037525 -GII-LRGS-KRLQVNIYVRHIDGFD---ET-GNI--K-TLVFPVMYLNE---SVLIDKDSATKLKS-VINTTMVITNIPY--IIMALGVFLGLIFTWMAC-----------------KG P_pygmaeus_ENSPPYP00000016592 -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKETASRLKS-VINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG T_rubripes_ENSTRUP00000042953 -GVP-IRAC-KRAQLNIILKRVQGFP---ST-RFL--N-ETIFPIMFVNE---TATIDDDSASQMRT-LLLIVTLVSNFPL--LIVGMGIILLLVLVVLFC-----------------RN R_norvegicus_ENSRNOP00000003052 -GII-LRGA-KRFQINTYVKKLDDFV---ET-GNI--R-TMVFPVMYLNE---SVLIDKETASQLKS-VINTTLIVTNIPY--IIMALGVFFGLIFTWLAC-----------------RG O_latipes_ENSORLP00000001610 -GVP-LNVS-IRLQLNLYIKSVSGIT---ET-GKI--S-EVVMPLLWFEE---SGYIDGPVLNTFRTNLVVLPTVMEYMQY--LLIALGLVTVVVASVVHH-----------------KV D_rerio_ENSDARP00000023056 -GVP-IRAC-KRAQLNIILKRVRGFP---NT-KFL--N-ETIFPIMYVNE---TATIDDESAAQMRM-LLLIVTVVSNFPV--IILALGVILLVVLIFLVC-----------------RN P_troglodytes_ENSPTRP00000009553 -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGETLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS H_sapiens_ENSP00000261693 -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGETLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS M_musculus_ENSMUSP00000031377 -GII-LRGA-KRFQINTYVRKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVLIDKETANQLKS-VINTTLVVTNIPY--IIMALGVFFGLVFTWLAC-----------------RG O_latipes_ENSORLP00000008151 -GVI-LRAS-KRAQVNILMNRVGGFP---DT-KNL--N-ETVFPVMFLNET-QSVVIDDESAAKVKK-LLLISDLVSNFAL--FIVGLGGIMLIILVVLLF-----------------RA T_nigroviridis_ENSTNIP00000018658 -GVP-IRAC-KRAQLNIILKRVQGFP---NT-RHI--N-ETIFPIMFVNE---TATIDDDSASQMKT-LLLIVTIVSNFPW--LIVGISVLLLLIM-VLFY-----------------RN G_gallus_ENSGALP00000004761 -GIP-MNCS-IKLQLNQYMKQVSGIL---QT-GKI--Q-PVVMPLLWFAE---SGYIDGSVLSQFYTNLVLIPSILDYLQY--IFLGLSVPLIISAALVMM-----------------SQ T_rubripes_ENSTRUP00000019814 -GVV-LRAA-KRLQVNVHVEKLPHYS---ET-GDV--R-TLIFPVVYLNE---SALVDDDAAQKLQG-VVRVQEVVVQVPF--MLIGLGFLLGLVFVFLMC-----------------RQ B_taurus_ENSBTAP00000014549 -GII-LRAA-KRFQINVYVRKLDDFI---ET-GNI--Q-TLVFPVMYINE---SVLIDKETASRLKS-VINTTLIVTNIPY--IIMALGVFFGLIFTWLAC-----------------RG T_nigroviridis_ENSTNIP00000016587 -GVP-LNVS-IRLQLNLYMKAVAGIT---ET-GKI--S-EVVMPMLWFEE---RGYIDGPILTTFHTNLVVLPAVMEYMQY--GLIALGLATIIIAAIVHH-----------------RV E_caballus_ENSECAP00000022283 -GVI-LRAA-KRFQINVYVRKLDEFS---ET-GNI--R-TLVFPVMYINE---SVLIDQETASRLKS-VINTALIITNIPY--IVMALGVFFGLIFTWLAC-----------------RG O_anatinus_ENSOANP00000002110 -GIP-MNCS-VKLQLSLYIKAVRGIM---QT-GKI--Q-PVVLPMLWFGE---SGMMGGKTLKTFYTQLVLMPSVAQYVQY--VFIGLGGVLLIISFILQV-----------------RS T_nigroviridis_ENSTNIP00000002999 -GVV-LQAA-KRLQINVHVEKIPHYS---QT-GNV--R-TLVFPVVYLNE---SALIQDAAARKLRA-VVTVQQVVVQVPF--MLMGLGFLLGLVFTVLVC-----------------RH T_rubripes_ENSTRUP00000047691 -GVP-LNVS-IRLQLNLYMKRVRGIT---ET-GKI--S-EVVMPMLWFEE---RGYIDGPILNTFHTNLVVLPAVMEYMQY--GMIALGLATIIIAAFVRY-----------------RF T_nigroviridis_ENSTNIP00000010349 -GVI-VRAN-KRAQVNILLRTVCVMM---KT-RVL--N-ETVFPVMFLNE---SVVIDDASAARVQK-LLNIANVVSNFPL--IIIGLGAIMLAIFIVLLI-----------------RA T_guttata_ENSTGUP00000005161 -GIP-MNCS-IKLQLNPVHKRVSGIT---QT-GKI--K-PVVLPLLWFAE---SGSIEGSVLKQFYTNLVLLPSVLEYLQY--TLLGLSAPLIISAAVLMA-----------------MR M_domestica_ENSMODP00000019581 -GIP-MNCS-VKLQISLYMKSIPGIG---QT-GKI--N-PVVLPLVWFEE---RGAMEGQTLSVFYTRLVLMPKLIQYLQY--VLNAVGCLFIIITLILVI-----------------RN A_carolinensis_ENSACAP00000014578 -GIP-MQCS-IKLQLNIFTKQVPGIL---QT-GRV--K-PVVLPLIWFAE---SGEVEGSILHDFYISLVLIPAVMGYAQY--CLVALGGLLFIVAAFLGL-----------------KS C_familiaris_ENSCAFP00000012634 -GII-LRAA-KRFQINVYVKKLDDFI---ET-GNI--R-TMVFPVMYINE---SVLIDKDTASRLKS-VINTTLIITNIPY--IVMALGVFFGLIFTWLAC-----------------RG B_taurus_ENSBTAP00000018959 -GIP-MNCS-VKLQLSLFVKSVKGIG---QT-GNI--Q-PVVLPLMWFEE---SGAMEGETLETFYIQLVLMPKVLHYAQY--VLLALGCVLLLIPIIYQI-----------------RS T_rubripes_ENSTRUP00000036580 -GVI-VRAN-KRAQVNILLGRIPGFP---KT-RSL--N-DTVFPVMFLNE---SVVIDDASAARVHK-LLTISTVVSNFPL--IIMGLGVVMLAIFIVLLI-----------------RA G_aculeatus_ENSGACP00000021517 -GVI-VRAN-KRAQINMLIERLSGFP---KT-KVL--N-ETIFPIMFINE---SVVIDDASAARVHK-LLLIVTVVSNFPL--FIVGLGGIMLLVFIVLLF-----------------RA R_norvegicus_ENSRNOP00000001301 -GIP-MNCS-VKMQLSLYIKSVKGVG---QT-GKI--E-PVVLPLLWFEQ---SGMMGGKTLNTFYTQLVLMPQVLHYAQY--VLLGLGGLLLLVPIIYQL-----------------RS P_pygmaeus_ENSPPYP00000005810 -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGETLHTFYTQLVLMPNVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS M_musculus_ENSMUSP00000083242 -GIP-MNCS-VKMQLSLYIKSVKGIG---QT-GKI--E-PVVLPLLWFEQ---SGAMGGKPLSTFYTQLVLMPQVLHYAQY--VLLGLGGLLLLVPIICQL-----------------RS D_rerio_ENSDARP00000076810 -GVP-VRAM-KRAQINIHLERVTGFP---MT-RNL--E-STIFPIIFLNE---------------------------------------------------------------------- A_carolinensis_ENSACAP00000012360 -GVL-VRAA-KRMQVNVHIQKLPDFL---QT-GNI--R-TLFFPVLYINE---SVVLDRASAVKLKA-VLFESSVVTNIPF--IIMVLGVIFGVVFVVLAC-----------------KP X_tropicalis_ENSXETP00000002583 -GIP-MNCS-IKMQLNMLTKSVSGIM---QT-GQI--K-PVILPVLWFAE---SGHLDGPVYNTYYNILILMPIVLEYLQY--VLIGIGLCFITVALVLPF-----------------VK C_familiaris_ENSCAFP00000010357 -GIP-MNCS-VKLQLSLYIKAIKGIG---QT-GKI--Q-PVVLPLVWFEE---SGAMEGKPLKTFYTQLVLMPNVLHYAQY--VLLALGCILLLIPIIHQL-----------------RS C_intestinalis_ENSCINP00000025688 -GAV-FSAM-KRLQLNVDMKNSTVFP---KM----------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000016695 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000458 -GVP-IRAC-KRAQLNVIVKRIPGFP---KT-RHI--N-ETIFPIMFVNE---TATIDDGSAAQMKT-LLLIVTLVSNFPV--FIVGMGIILLLVLVVLFC-----------------RN A_gambiae_AGAP004846-PB -GTA-LRAR-ARIQINLAVSQVVDIK---QV-ANF--P-DIVFPILWFEE--GIDSLPDEILDLMKVATNIPPRAKFILTI--ALFGLGGFLFVVAVICLV-----------------RK M_mulatta_ENSMMUP00000038414 -GIP-MNCS-VKLQLSLYMKSIAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGETLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS D_melanogaster_FBpp0072308 -GTT-LRVR-ARIQINLAVSQVFDIK---QV-ANF--P-DIIFPILWFEE--GIDNLPDEVTDLMRFAEQVPPKIRVALIV--GLCALGVILLLLSTFCLI-----------------RN A_aegypti_AAEL000256-PA -GTA-LRAR-ARIQINLAVSQVVDIK---QV-ANF--P-DIVFPILWFEE--GIDSLPDPILDLMKVATTVPPKAKFVLTI--ALFAIGGFLFVIAVFCLV-----------------RK E_caballus_ENSECAP00000021856 -GIP-MNCS-VKLQLSLYMKAVRGIG---QT-GSI--Q-PVVLPLLWFGE---SGAMEGKTLQSFYSQLVLLPKVLHYAQY--VLLALGCVLLLVPIVYQI-----------------RS D_melanogaster_FBpp0110185 -GTP-LQGG-KRVQFNMFLKSINRIG---IT-ENL--P-TVLMPAIWVEE---GIQLNGEMVAFFKKKLINTLKTLNIVHW--ATLCGGIGVAVACLIYYI-----------------YQ D_rerio_ENSDARP00000089887 -GVP-VNVS-VRLQLNLFLKKVSGIS---ET-GNI--A-EVVMPMLWFEE---TKYIIGCILHSFISVLFIYLFILDSFIV--LFIYLFYLCVCAYIIMFL-----------------FK A_gambiae_AGAP010133-PA -GIP-LDVR-AQLQINEHLQPIKGFS---FY-EHV--P-DVMVPMIWFRQ---RATLTQELAEQAKL-ALALPSLGIYVAV--FFGSIGIIMTSVFLFCSI-----------------KK D_melanogaster_FBpp0079088 -GIP-LEVA-ARFQVNMLVEPIQGIS---LY-TGI--P-RIFFPLVWFEQ---KVRITPDMADQLKV-LPIVMLSGHIFAG--ICLIVGITLLCWTPVQIL---------------LASC A_gambiae_AGAP004845-PA -AFP-IDGA-SRFQINIQVQKAAMVS---GL-EKF--TEGQYLPVIWLEV--VPGVISDDLRAMIYHSTYSANAIQMSL-------RVGSLAFFVLSVVL-------------------- A_gambiae_AGAP005716-PA -GTP-LNGG-KRVQFNMFLRRIDAIK---LT-DRL--Q-PTLFPVIWIDE---GIALNEDMVKLIDDSLMKVLSLLDVVQW--VLIGVGLLLAVLMPTVYF-----------------VK A_aegypti_AAEL000227-PA -AFP-IDGA-SRFQINIQVKKTSYIS---GL-EPF--NDGQILPVIWLEV--VPGHISEELRNMIYHSTFSANAIQFSFKY-------GSLLICVTTFALL------------------- A_gambiae_AGAP003373-PA -SVP-LDVA-ARLQLNIMIEPYENIN---LF-SDV--K-RVFLPVLWFEQ---HVLMPSELAGEIGQ-ALTIPSIVRLCGI--AMVVFGALMLLWIPLERT-----------------FF D_rerio_ENSDARP00000071723 -GIV-LQGA-KRVQVNVYLQQHSSFS---QT-GKI--Q-TLVFPVMYINE---SAFIDEESAKKLHA-VVLNANVVINIPF--IVISVGILLGIIFIVLMC-----------------RQ D_melanogaster_FBpp0077748 -GVP-VQVH-GRIQINMMIEPDDDFD---IY-RGV--Q-KVLMPMFWFDQ---YAELSSELASKAKL-AINLSSYGIIFGY--SMIAFASVFLITGITLTV-----------------TK O_cuniculus_ENSOCUP00000002939 -GII-LRAA-KRFQINVYVKKLDDFL---ET-GDI--R-TMVFPVMYLNE---SVLLDKESASRLKS-VINTTMIITNIPY--IIMALGVLLGLVFTWLAC-----------------RG C_intestinalis_ENSCINP00000011713 -GAV-FSAM-KRLQLNVDMKNSTVFP---KM-ANL--P-KVILPTLWLNE---SVVLDRVTANQFKSEVLGLIKAVHAVPC--ILLAIGGFLFVLALALLA-----------------HR A_gambiae_AGAP002738-PA -GLP-LELS-VKFQINMVLDDLSSMA---HC-EKF--S-KLVVPALWFEI--MMPGLPPTLLSRFLFYLKILPFGDQVVKH--SLLAFGGILLLVAITKVS-----------------LT A_aegypti_AAEL009423-PA -GIP-LDVR-ARLQINTHLQPIKGIG---MY-KDV--P-DIMVPMMWFTQ---RATLTPELANQAKM-ALVLPALGIYIAI--FFGTTGTILVGIFAYICI-----------------RK D_melanogaster_FBpp0072303 -GFP-ISGA-SRVQINIMLDKTPILR---NQGDRL--KNTTILPLMWIEI--TSGDFSEEVLHTLYLSTFGLNAIQQTLKYGTLLISVTSFSLIVAGVYYL-----------------NS A_gambiae_AGAP008179-PA -GVP-LGVR-AQLQVNLDVKQY-GMT---LL-KGI--P-EVMLPVLWFRQ---TASLTEELADDIKV----------------------------------------------------- A_gambiae_AGAP005725-PA -GVP-LEGQ-VRVQLNLLVEKAPNVM---AT-KDF--R-DFVFPIMWLEE--GVSELTPPIRRWIYLATVFAPTALPILSY--GMILTGAFAMIYVFVRAYKNFVFTDDPTTELLEMGRR G_aculeatus_ENSGACP00000018249 -LVSDIPAA-GRTRTDKVFSPQMHCW---NT-RRV--C--------TINR-------------QMRFNLIPAYKVLVAETN--LILVMGIILLLVLVVLFC-----------------RN A_aegypti_AAEL009432-PA -GIP-LQVK-AQLQVNLLMEDY-KLT---LL-EGI--P-KIMLPVLWFRQ---TAQLNEDLASDLKT-LLVLPYIGIYVAI--GVGILGVFCLALFLHYSL-----------------KV G_gorilla_ENSGGOP00000006367 -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGETLHTFYTQLXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX-----------------XX D_melanogaster_FBpp0079175 -GVP-MDVG-GGFQANYYMEPIPGIT---LY-ENV--P-TVMIPMMWCEE---RVRVSEEIAADIAL-VPLIVLLGQIVTG--ILLAGGLICTCWYPTRQV------------------T D_melanogaster_FBpp0112038 -GVP-LEGK-VRIQLNLKVTRAKDVY---PV-RDF--R-DFVFPVMWLEE--GISELTPAIKRWIYLGTVIAPSAVPIGSY--LMILGGAFAIIFSFVRAYQNFMFAQDPTLEILEMGRR A_aegypti_AAEL011222-PA -GLP-LKLS-VKFQINMAMGDISNMA---EC-ERF--A-NIVIPTLWFEI--TMLQLPRGLRNRFLFYLKYLRIFDRIMYF--LLLVGGSLLLLYAVIRVA-----------------LS C_intestinalis_ENSCINP00000010908 -GMI-IKTE-SRIQLNIYMKPNKKVK---AL-NKI--QEEFGFPLLWLNE---NAVLQPSEASWFSKLLYKVDDVVILLQV--LICVLGAALMSLSLLCYL-----------------RC C_elegans_C03F11.3 -GTV-LQAQ-KRLQINMLVNQFKHIR---SY-SVM--R-PGAYPLAWVNE---SFYMDQNTIDQLNSQLFTPVSTVNTICW--IAVGLGAGLIALSIVMVI-------------VSFCCF A_aegypti_AAEL005979-PA -GVP-LEGQ-VRVQLNLLVEEAPNVM---AT-KNF--R-DFVFPIMWLEE--GVSELTPPIRRWIYLATVFAPMALPIVSY--GMILTGTFALIYVFVRAYKNFVFTSDPTTEFLEMGRR D_melanogaster_FBpp0110565 -GLP-LSLS-VKVQINMHFKDLSNFP---VV-SVF--N-HLTVPMLWFEI--MMSKLPDSLDSRFNFYLNILPLVNPLGFW--SGILLGISLLGYAITKAT-----------------LH D_melanogaster_FBpp0080584 -GVP-LKVN-ANVMITLYIEPDSVID---IL-KGL--P-SFYAPLFTTAS---RAEIDEALASELRL-ALNLPAIGRYTGV--GFLCLGCILIAVGILLTI-----------------KR D_melanogaster_FBpp0079173 -GMV-LEIK-ARIMANLLVEPKTHL----IY-RTA--R-RTFFPLIWADY---NVRITDDLLVYVKL-MPILEFVGKICGI--LGVVLGLLMVFWYPHQMI-----------------WQ D_melanogaster_FBpp0083430 -GTP-FQAA-KRLQFNLDMEPVEGIE---PM-KNL--P-KLILPMFWVEE---GVQLNKTYTNLVKYTLFLGLKINSVLRW--SLITFSLVGLMFSAYLFY------------------H C_elegans_Y76A2B.6 -GAV-LYAR-RVSQVNIEMWKGKNLTFPVNL-KKM--K-SALIPVLILHE---TSEIDDDSLEQIRSQLYETESIAYTSCD--VMMIIGAIMLLLGFLFLS------FSLGLCDPILGRR D_melanogaster_FBpp0082805 -GAP-MQGTHLRLQANQVVGKVNFNR---MM-TPF--E-NMILPLLWVDL--NIDVLCLTLRLLIHGIKWGFPLLQWSAAL--GMLLAGVYQLCSALLLCF-----------------WP A_aegypti_AAEL002741-PA -GIP-MTAS-IRVQINL-LTNVKFIS---DL-KPL--D-KTVIPLIWAQM---VSCLEL------------------------------------------------------------- C_elegans_Y49E10.20.1 -GVP-TQAK-RIMQINVGMVK-GSLS---VT-ENT--T-NVVVPVLWMNE---TAYFDQGTRDQLIN-IFNAKHYSFIGGV--ISLSLGLIAWLAVFVVII--------------VYSRQ A_aegypti_AAEL008370-PA -GIP-LDVA-ARFQLNILIQSHPSIA---LY-EDV--P-RVFLPVLWFEQ---HVTMRPEFTGEIAQ-ALSIPTTARICGI--VMLVLGAIMVAWIPIERL-----------------MF A_aegypti_AAEL005374-PA -GTP-VSAA-KRLMFSMEIEPIRDHA---VL-GNL--P-TVILPLFWAEE---GASLNKTWTNQLKYTLFLGLRFNTAVKW--LTIIIGTIGTIVGGFMHY-----------------KR D_melanogaster_FBpp0080585 -GIP-LSLR-GQLMISTKVVRDEAID---LF-KNV--AYDHYAPLFTMRL---HAELDEGLTKLLKL-ALNAAIIGMYTGI--GLVLLGMSIVVTGIFITK-----------------KH A_gambiae_AGAP004643-PA -GIP-MKAN-IRVQISL-LTNVSFNS---EL-RPF--H-NTVIPLIWAEM---VRQ---------------------------------------------------------------- A_aegypti_AAEL007748-PA -GTV-LRSS-IKLQINALLQRYNGVA---LY-QDA--P-RSFVPLLWYSK---SFDLPLEEAVKLRS-LLDVSQLGYLGGF--AVAAFGLLVAILAMGLRC-----------------AI A_gambiae_AGAP002451-PA WVSP-VSAA-KRLQFSMELGPIRDHE---LF-GQL--P-DVILPMFWAEE---GASLNKTWTNQLKYQLFLGLKFNATVKW--LTIIIGTVGAVGSAYMYF-----------------RK G_gorilla_ENSGGOP00000008199 -XXX-XXXX-XXXXXXXXXXXXXXXX---ET-GDI--R-TMVFPVMYFNE---SVHIDKETASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG A_gambiae_AGAP010132-PA -GIP-MAAN-GRIQYNMHLRDN-GMA---LF-RDV--P-DVIIPAFWIEQ---RMVLTKDIADDLKVQLL-------------------------------------------------- A_aegypti_AAEL009420-PA -GVP-MSVN-GRLQYNVHVKDY-GLD---AT-RGV--P-DVMLPAFWVEQ---RVLLTQQVIDDLMY-IDTLRSAGHITAF--VLVGVGVIAFGVALYFSI-----------------FV A_aegypti_AAEL000234-PA -GIP-IDQR-ARTQSNLVIPSLTGFS---NDIQKF--S-NMILPMFWIEY--HQNELPLRIINLIRI-FNIVKDIQSYLPF--VFYALFILLLLIALNKAW-----------------KI C_intestinalis_ENSCINP00000027668 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004847-PA -GIP-LDQC-ARTQTNLAIPELTGYS---ADIKRF--S-DMIIPMFWIEY----VRLSDSALTEMNEK---------------------------------------------------- A_gambiae_AGAP012849-PA -GIP-MAAN-GRIQYNMHLRDN-GMA---LF-RDV--P-DVIIPAFWIEQ---RMVLTKDIADDLKL-IEDLRWGFIYTAF--ALCGVAALLLGLSLYAAF-----------------FV C_elegans_F11C1.3 -GST-IGGE-FRMMLSIPVFQSLAWT---LM-SNA--P-NAIMPSFTLTI---GVVMKDYAVNYIYFNTVTIPNIVLGLGI--GFTAVSLIAVLLWGFCYF-----------------RS D_melanogaster_FBpp0072310 -GIP-VTEK-YRFQSNIPIPDLRRFS---SRLSRF--S-NMMIPSFWYEF--EMGQLPGFVTSLMWINVNIVQHIQPYCMV--LFLVLALWSVLKAIRVACGDLGYVVLFRKLCGDLGTV C_elegans_F07A5.3 -GTT-LKVV-NRLQVNMPVIRSHDVP---SS-QNM--P-NVMIPLFWQDT---SPKYHQFIFNEVWLGFVLVPRLMRVLQF--VALGIGLLLVAIIVFLQL------------------R C_elegans_R07B1.3 -GTA-LQVD-VRFQVNLPVVNNKGSI---MS-SQM--P-NVIIPLFYEDS---HALVKDFVMDTVWLGVIIVPRIIEYLKF--VLSFISICILTTLLVIRV-----------------RV A_gambiae_AGAP000016-PA -GTV-IESN-IDLTYHTFLRPNEHIA---LF-QSV--P-ELRIPLFRFAR---YYRLSELKAAKLRQ-LLHLLDVGHQIAL--AGCVAGLTIILLAVVYAC-----------------WK 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000080974 KSKNG--K---------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000008319 RSKNG--K---------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000058398 RSKNG--K---------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000009599 RSKGK--R---------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000020018 RSKTI--K---------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000033093 RSKTI--K---------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000023750 RSKRV--N---------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000308165 RSKTI--K---------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000013084 RAKKV--K---------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000021313 RSKKV--K---------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018902 RLKNA--K---------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000005521 RTKSI--K---------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013734 RSKKL--K---------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000002156 RTKTV--K---------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000002704 RSKKL--K---------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015615 RVQKS--K---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017231 GSKKQ--R---------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000041076 RNKRG--KL--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000050752 CSKPS--KT-NLS----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000020106 RRSHK--RS-KTV----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000014345 WRKHW--N---------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000026365 RRNDN--QN-FLWCQKENTVILK------------------------------------------SS----------------------------------------------------- G_gorilla_ENSGGOP00000005986 RSKTI--K---------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017237 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001744 QRITE--ES-TEEERSPLIRT--------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000052043 KRSRD--EG-TEEERGPLIRAS-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000027514 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000018715 QGARE--ES-TEEERSPLIRT--------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022821 KVPED--KG-KKNERGPILCLS-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000264896 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000012225 KVPES--TS---AERQPLLSS--------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000014317 QGSMN--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000027814 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000037525 QGSAE--EG-TADERAPLMRT--------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000016592 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042953 RQKKS--EV-KRIDFTEAFHS--------------------------------------------LTTTKDETAYTQVSDKPDDPSQSATSQPKRNGSYIAMSPVEAQKC---------- R_norvegicus_ENSRNOP00000003052 QGSTD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001610 KNGRR----GSRKDSNPQPAGQK------------------------------------------TQNPSAGSALVPAE----------------------------------------- D_rerio_ENSDARP00000023056 RQRKN--EV-KRIDFTEAFHS--------------------------------------------FATTKDETAYTQVSNQAEDSPENRNNQPLRNGSYIAMSPVEAQKC---------- P_troglodytes_ENSPTRP00000009553 QEKCY--L----FWSSSKKGSKD------------------------------------------KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- H_sapiens_ENSP00000261693 QEKCY--L----FWSSSKKGSKD------------------------------------------KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- M_musculus_ENSMUSP00000031377 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008151 HQKKN--EV-NRIVFTKALYA--------------------------------------------QPSAQDDTSYCPVGDKGREDPQN-------------------------------- T_nigroviridis_ENSTNIP00000018658 RQKKN--EV-KRIDFNEAFHS--------------------------------------------LTTAKDETAYTQVSDKPDDSSQTATTQPKRNGSYIAMSPVEAQKC---------- G_gallus_ENSGALP00000004761 KSSKE--KH-PHDPTTQSPPPQP------------------------------------------SETTPLL----QDTGTQSQDTAEA------------------------------- T_rubripes_ENSTRUP00000019814 KLPST--PGLLLSPRAPLRSDSRCSPLKAPSQ---------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000014549 QGSTD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000016587 KRNKR----GGGATSEGEARASA------------------------------------------EEKDPLLQDDVD------------------------------------------- E_caballus_ENSECAP00000022283 QGSLD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002110 QDKCF--L----FWSSSKKGPKN------------------------------------------KEAIQVY----SE--TLMTSTHNGTVLQEARL----------------------- T_nigroviridis_ENSTNIP00000002999 RTPQHTPPESTAAERQPLLSS--------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000047691 KRHKC----GGGATSKGEASASA------------------------------------------GEKDPLLQDDVD------------------------------------------- T_nigroviridis_ENSTNIP00000010349 HRQKN--GV-KNIVFTKALYS---------------------------------------------ASTEEDT-YSPVNDKEKEDPQNGTYIGLADKN--------DPQA---------- T_guttata_ENSTGUP00000005161 KGSVT--E----SSDTQSKATPS------------------------------------------SETTPLL----CD--SPSQDSPEA------------------------------- M_domestica_ENSMODP00000019581 QGTFF--L----FWSSDKKVSKN------------------------------------------SEAIQSY----SE--SLMTPAPNGTVLQEARL----------------------- A_carolinensis_ENSACAP00000014578 KGKCF--L----FWSSNKGSESK------------------------------------------GATQS-------------------------------------------------- C_familiaris_ENSCAFP00000012634 QGSMD--EG-TPDERAPLIRT--------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018959 QEKCY--L----FWISFKKGSKD------------------------------------------KEAVQAY----SE--FLMTSAPKGTVLQEARL----------------------- T_rubripes_ENSTRUP00000036580 RQQKN--EV-KRIVFTKALYSRT------------------------------------------QASTEEDTSYSPVNDKEKEDPQNGTYIGLAGRSLVLLKSVSRTKC---------- G_aculeatus_ENSGACP00000021517 RKQKN--EV-KRTVFTKPLYA---------------------------------------------TSNEEGTSYSPVSDKEKEDPQNGTYISLTPKG--------DPEA---------- R_norvegicus_ENSRNOP00000001301 QEKCF--L----FWSGSKKGSQD------------------------------------------KEAMQAY----SE--SLMSPAAKGTVLQEAKL----------------------- P_pygmaeus_ENSPPYP00000005810 QEKCY--L----FWSSSKKGSKD------------------------------------------KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- M_musculus_ENSMUSP00000083242 QEKCF--L----FWSGSKKGSQD------------------------------------------KEAIQAY----SE--SLMSPAAKGTVLQEAKL----------------------- D_rerio_ENSDARP00000076810 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012360 SQARE--EG-SVDERAPLIRT--------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000002583 QGKCF--L----FWNSNKNVDES------------------------------------------QEFKTQ---------KEKLTAPNGIVLLEARL----------------------- C_familiaris_ENSCAFP00000010357 QEKCY--L----FWSSSKKGSKD------------------------------------------KEAIQAY----SE--SLMTPAPKGTVLQEARL----------------------- C_intestinalis_ENSCINP00000025688 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016695 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000000458 RQKKN--EV-KRIDFNEAFPS--------------------------------------------FAVS--------------------------------------------------- A_gambiae_AGAP004846-PB SHRQS--TL-HLEGSNYLATASV------------------------------------------DQAKKKAKMDNGMSSKSN------------------------------------- M_mulatta_ENSMMUP00000038414 K-----------VGAGQSVARAD------------------------------------------SYSLACWGKGASD--RTLWPTAAWSPPPAAVLLLCWSGSGHRWGLRCRLASFACR D_melanogaster_FBpp0072308 SHRQS--TL-HLEGSNYLATAQV------------------------------------------DMNKKQNKDNQPARY---------------------------------------- A_aegypti_AAEL000256-PA SHRQS--TL-HLEGSNYLATASI------------------------------------------DQAKKKAKLENGSHTN--------------------------------------- E_caballus_ENSECAP00000021856 QEKCY--L----FWSGSKKGSKD------------------------------------------KEATQAY----SE--TLMTSAPKGTVLHEARL----------------------- D_melanogaster_FBpp0110185 RGRVV--EP-PVK----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000089887 QVKSK--TS-GSSSTDVDPSSTT------------------------------------------SEKAPLLQSPTS------------------------------------------- A_gambiae_AGAP010133-PA WSQSA--EV-VPYEELQN------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0079088 RNRRY--DL-RTKTKTNGQYKSR------------------------------------------SQFSSAEELKSKASTLVCEKSVKGSPDSSPLLEKGRKPTIIKSQTGESVATASTA A_gambiae_AGAP004845-PA -----------LIAKCFYSTRST------------------------------------------S----------------------K-----------------------K------- A_gambiae_AGAP005716-PA RCRGE--GS-RTVSPAVTATTSA------------------------------------------ASLSTVAGVTGDRSK---------------------------------------- A_aegypti_AAEL000227-PA ------------AMTCYFRTKNA------------------------------------------DDTNSEKPEDQPTVKLNSMNSEIRS------------------------------ A_gambiae_AGAP003373-PA RRRRV--A---------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071723 Q----------------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0077748 KWVRR--TP-EDEDILTN------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002939 QGSMD--E---------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011713 YHKEK--TQ-LNIQEDSIRSLLT------------------------------------------ENDSFTDGA---------------------------------------------- A_gambiae_AGAP002738-PA LSSAY--SS-AYRISNELRESLW------------------------------------------------------------------------------------------------- A_aegypti_AAEL009423-PA WSSQ------VPYEELLR------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0072303 RREQQ--LQ-ESKTSAELEALNG------------------------------------------GENVIVVHHIDMPVPLPVQDGGIHQGT---------------------------- A_gambiae_AGAP008179-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005725-PA SLRRG--SH-LISNGQHRIL--H------------------------------------------RDSYILLKANGVVAAAGGESDIAGTGTEVVTSGNGSSNNNNHLLHNHNLLHSHH- G_aculeatus_ENSGACP00000018249 RQKKN--EV-KRIDFTEAFHS--------------------------------------------FTTVKDDTAYTQVSDKPDEPSAN---QPTRNGSYIAMSPVEAQKC---------- A_aegypti_AAEL009432-PA WK---------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006367 XEKCY--L----FWSSSKKGSKD------------------------------------------KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- D_melanogaster_FBpp0079175 HFCHS--DP-KAKASVLRPLNAF------------------------------------------GVNSSAATAPVAQLFRNNISSSGNERVGVRLLDYNRDSGIRLESGTMESSHRERL D_melanogaster_FBpp0112038 SLRRG--SS-FIAHQQHRLLVHH------------------------------------------RDSYSLLRH-GPMATCLGEGNREEDAQPII------------------------- A_aegypti_AAEL011222-PA VSLSL--TS-NNISRKNKKISKS------------------------------------------ERCAENRRHSLLKNNSSKLEKGSVQEREHFLT----------------------- C_intestinalis_ENSCINP00000010908 RKAYK--TT-KRAGSRKNLIIGQ------------------------------------------YNKDAELPTVTQNCVKF-------------------------------------- C_elegans_C03F11.3 RDEHH--KT-S------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL005979-PA SLRRG--SS-MIINGQHRILM-Q------------------------------------------RDSYILLKA----------SEDANLYHHTSNNNTINTNNNLSSHHNHNLFHLPHL D_melanogaster_FBpp0110565 MSTFS--RR-AANITDVKYVRANLIQNIAGEAANHAYSPCDIKLLDDISVVRHPVNKQTVQDSGFSSKTTYALDMEPALLDTSESSDEGRDCDIVTISRNSTSTRFCADEKKCWLGDDIR D_melanogaster_FBpp0080584 KWYGQ--AE-LDKLALKDNEETPYEPEVPANVVERNF----------------------------------------------------------------------------------- D_melanogaster_FBpp0079173 KSLMH--KI-EISSIETNSSLEP------------------------------------------VKNNDVEDSPLLKGLQYAAAKDGAGNGN--------------------------- D_melanogaster_FBpp0083430 KSDSL--DI-NSILKDNNKVDDV------------------------------------------ASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY------ C_elegans_Y76A2B.6 SKRAN--GL-SPEPLPPYVPKGE--------------------PNGYHHNHAYITGLFGKNFSNFEKNPIFKPSSVFFSNFQLFPLKIIFSVSVNFVNIALLVFLPIFITHTISPESPFF D_melanogaster_FBpp0082805 TARQF--QK-VDQVERGTAVQVI---------------------------------GVGLGLATGLRKPSIHLDPEEQHHLLLGGGSFIPKMAKT------------------------- A_aegypti_AAEL002741-PA ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y49E10.20.1 SDEEE--YG-RLVLEDEDEEPAQ------------------------------------------DENAVLA------------------------------------------------ A_aegypti_AAEL008370-PA RSRRR--DI-VTDAGTEKVLLQQ------------------------------------------NLAKTAILVPEKEKEAVADKLSTIVEAHPLIESKTVRLGAENGTTKT-------- A_aegypti_AAEL005374-PA TTKMV--NV-TPVQSVNGSSAKG-----------------------------KGAGMTVVGHQPDSKGGSVTAPVIPSAKDLLQN---SRNLPTVIEGLDKPQKVTVTEMQERY------ D_melanogaster_FBpp0080585 KWHSE-----QRPDKHLQCTQN-------------------------------------------------------------------------------------------------- A_gambiae_AGAP004643-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007748-PA RSTQK--KS-RGEGPRPVANGDT------------------------------------------RGEYEFVQNEQNKDKDRIKL----------------------------------- A_gambiae_AGAP002451-PA ETKTT--DV-APVDVSTPDTNPS------------------------------------------------------SAKDGVVNVSLGRNLPPVID----------------------- G_gorilla_ENSGGOP00000008199 QGSMD--EG-TADERAPLIRT--------------------------------------------------------------------------------------------------- A_gambiae_AGAP010132-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL009420-PA WKN--------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL000234-PA DSKYI--QI-PSVMIQEKCLQNN------------------------------------------NNSDLIKQ----------------------------------------------- C_intestinalis_ENSCINP00000027668 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004847-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP012849-PA WKD--------------------------------------------------------------------------------------------------------------------- C_elegans_F11C1.3 KRNAK--PF-VLQQHRTEPTWSVAE----------------------------------------------------------------------------------------------- D_melanogaster_FBpp0072310 TALET--KF-QATSASPDVAVK-------------------------------------------------------------------------------------------------- C_elegans_F07A5.3 KGKPS--LI-RPLKTSFLETTSN------------------------------------------WLSSTSSSNSNESRGLRRM------------------------------------ C_elegans_R07B1.3 KGTVS--VV--------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP000016-PA AQRPS--KT-NNDQYRIIGMQLSD------------------------------------------------------------------------------------------------ 970 980 =========+=========+= M_musculus_ENSMUSP00000080974 --------------------- R_norvegicus_ENSRNOP00000008319 --------------------- R_norvegicus_ENSRNOP00000058398 --------------------- C_familiaris_ENSCAFP00000009599 --------------------- P_pygmaeus_ENSPPYP00000020018 --------------------- P_troglodytes_ENSPTRP00000033093 --------------------- B_taurus_ENSBTAP00000023750 --------------------- H_sapiens_ENSP00000308165 --------------------- E_caballus_ENSECAP00000013084 --------------------- M_domestica_ENSMODP00000021313 --------------------- B_taurus_ENSBTAP00000018902 --------------------- O_anatinus_ENSOANP00000005521 --------------------- G_gallus_ENSGALP00000013734 --------------------- O_cuniculus_ENSOCUP00000002156 --------------------- T_guttata_ENSTGUP00000002704 --------------------- A_carolinensis_ENSACAP00000015615 --------------------- X_tropicalis_ENSXETP00000017231 --------------------- T_rubripes_ENSTRUP00000041076 --------------------- D_rerio_ENSDARP00000050752 --------------------- O_latipes_ENSORLP00000020106 --------------------- T_nigroviridis_ENSTNIP00000014345 --------------------- G_aculeatus_ENSGACP00000026365 --------------------- G_gorilla_ENSGGOP00000005986 --------------------- X_tropicalis_ENSXETP00000017237 --------------------- T_guttata_ENSTGUP00000001744 --------------------- X_tropicalis_ENSXETP00000052043 --------------------- M_mulatta_ENSMMUP00000027514 --------------------- G_gallus_ENSGALP00000018715 --------------------- G_aculeatus_ENSGACP00000022821 --------------------- H_sapiens_ENSP00000264896 --------------------- O_latipes_ENSORLP00000012225 --------------------- O_anatinus_ENSOANP00000014317 --------------------- P_troglodytes_ENSPTRP00000027814 --------------------- M_domestica_ENSMODP00000037525 --------------------- P_pygmaeus_ENSPPYP00000016592 --------------------- T_rubripes_ENSTRUP00000042953 --------------------- R_norvegicus_ENSRNOP00000003052 --------------------- O_latipes_ENSORLP00000001610 --------------------- D_rerio_ENSDARP00000023056 --------------------- P_troglodytes_ENSPTRP00000009553 --------------------- H_sapiens_ENSP00000261693 --------------------- M_musculus_ENSMUSP00000031377 --------------------- O_latipes_ENSORLP00000008151 --------------------- T_nigroviridis_ENSTNIP00000018658 --------------------- G_gallus_ENSGALP00000004761 --------------------- T_rubripes_ENSTRUP00000019814 --------------------- B_taurus_ENSBTAP00000014549 --------------------- T_nigroviridis_ENSTNIP00000016587 --------------------- E_caballus_ENSECAP00000022283 --------------------- O_anatinus_ENSOANP00000002110 --------------------- T_nigroviridis_ENSTNIP00000002999 --------------------- T_rubripes_ENSTRUP00000047691 --------------------- T_nigroviridis_ENSTNIP00000010349 --------------------- T_guttata_ENSTGUP00000005161 --------------------- M_domestica_ENSMODP00000019581 --------------------- A_carolinensis_ENSACAP00000014578 --------------------- C_familiaris_ENSCAFP00000012634 --------------------- B_taurus_ENSBTAP00000018959 --------------------- T_rubripes_ENSTRUP00000036580 --------------------- G_aculeatus_ENSGACP00000021517 --------------------- R_norvegicus_ENSRNOP00000001301 --------------------- P_pygmaeus_ENSPPYP00000005810 --------------------- M_musculus_ENSMUSP00000083242 --------------------- D_rerio_ENSDARP00000076810 --------------------- A_carolinensis_ENSACAP00000012360 --------------------- X_tropicalis_ENSXETP00000002583 --------------------- C_familiaris_ENSCAFP00000010357 --------------------- C_intestinalis_ENSCINP00000025688 --------------------- T_guttata_ENSTGUP00000016695 --------------------- O_latipes_ENSORLP00000000458 --------------------- A_gambiae_AGAP004846-PB --------------------- M_mulatta_ENSMMUP00000038414 VATTLPVLEGLGPSLGGGAGG D_melanogaster_FBpp0072308 --------------------- A_aegypti_AAEL000256-PA --------------------- E_caballus_ENSECAP00000021856 --------------------- D_melanogaster_FBpp0110185 --------------------- D_rerio_ENSDARP00000089887 --------------------- A_gambiae_AGAP010133-PA --------------------- D_melanogaster_FBpp0079088 ISDNKQD-------------- A_gambiae_AGAP004845-PA --------------------- A_gambiae_AGAP005716-PA --------------------- A_aegypti_AAEL000227-PA --------------------- A_gambiae_AGAP003373-PA --------------------- D_rerio_ENSDARP00000071723 --------------------- D_melanogaster_FBpp0077748 --------------------- O_cuniculus_ENSOCUP00000002939 --------------------- C_intestinalis_ENSCINP00000011713 --------------------- A_gambiae_AGAP002738-PA --------------------- A_aegypti_AAEL009423-PA --------------------- D_melanogaster_FBpp0072303 --------------------- A_gambiae_AGAP008179-PA --------------------- A_gambiae_AGAP005725-PA -HHLYIQPKDQSLLAEEDSPA G_aculeatus_ENSGACP00000018249 --------------------- A_aegypti_AAEL009432-PA --------------------- G_gorilla_ENSGGOP00000006367 --------------------- D_melanogaster_FBpp0079175 ISEDSPDVVVR---------- D_melanogaster_FBpp0112038 ---------DVSLSGGISQES A_aegypti_AAEL011222-PA --------------------- C_intestinalis_ENSCINP00000010908 --------------------- C_elegans_C03F11.3 --------------------- A_aegypti_AAEL005979-PA PHIPHHQPKDQSLLSDEDSTA D_melanogaster_FBpp0110565 VECFTESRAPQTILKREEQIH D_melanogaster_FBpp0080584 --------------------- D_melanogaster_FBpp0079173 --------------------- D_melanogaster_FBpp0083430 --------------------- C_elegans_Y76A2B.6 PTSSSL--------------- D_melanogaster_FBpp0082805 --------------------- A_aegypti_AAEL002741-PA --------------------- C_elegans_Y49E10.20.1 --------------------- A_aegypti_AAEL008370-PA --------------------- A_aegypti_AAEL005374-PA --------------------- D_melanogaster_FBpp0080585 --------------------- A_gambiae_AGAP004643-PA --------------------- A_aegypti_AAEL007748-PA --------------------- A_gambiae_AGAP002451-PA --------------------- G_gorilla_ENSGGOP00000008199 --------------------- A_gambiae_AGAP010132-PA --------------------- A_aegypti_AAEL009420-PA --------------------- A_aegypti_AAEL000234-PA --------------------- C_intestinalis_ENSCINP00000027668 --------------------- A_gambiae_AGAP004847-PA --------------------- A_gambiae_AGAP012849-PA --------------------- C_elegans_F11C1.3 --------------------- D_melanogaster_FBpp0072310 --------------------- C_elegans_F07A5.3 --------------------- C_elegans_R07B1.3 --------------------- A_gambiae_AGAP000016-PA ---------------------