>M_musculus_ENSMUSP00000080974 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDMLIEKTIKREVVL----EE-GT----TAFKNW-VK---TGTTVYRQFWIFDV QNPDDVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPE D--HT-VSFVQPNG--AIFEPSLSVGT-E--DDNFTVLNLAV------------------ A------AA--------PHIYQN-------SFVQVVL--NSLIKKS---KS-SMFQTRSL KELLW-GYK---------DPFLSLVP---------Y---P------I----STTVGVFYP YNDTV--DGVYKV----------FNGKD-NISK--VAI-IESYKGK-------RN----- -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V- EKSRTLRFFSSDICRSIYA-VFGS--EIDL-KGIPVYRFVLP-ANAF-ASPLQNP-DNHC F--------------------------------CTEK----------VISNNC--TSYGV LDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIEGLH-PNEDEHR-TYLDVEPIT-- -GFT-LQFA-KRLQVNILVKPARKIE---AL-KNL--KRPYIVPILWLNE---TGTIGDE KAEMFKTQVTGKIKLLGMVEM--ALLGIGVVMFVAFMISYC-----------------AC KSKNG--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >R_norvegicus_ENSRNOP00000008319 -M-GC----------------------------------------------DRNCGLIT- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDLLIEKTIKREVVL----EE-GT----IAFKNW-VK---TGTTVYRQFWIFDV QNPEEVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPK D--ST-VSFVQPNG--AIFEPSLSVGT-E--NDNFTVLNLAV------------------ A------AA--------PHIYTN-------SFVQGVL--NSLIKKS---KS-SMFQTRSL KELLW-GYK---------DPFLSLVP---------Y---P------I----STTVGVFYP YNNTV--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------E--SYC--DMING--TDAASFPPF----V- EKSRTLRFFSSDICRSIYA-VFGS--EVNL-KGIPVYRFVLP-ANAF-ASPLQNP-DNHC F--------------------------------CTEK----------VISNNC--TSYGV LDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIEGLN-PNEDEHR-TYLDVEPIT-- -GFT-LQFA-KRLQVNILVKPARKIE---AL-KNL--KRPYIVPILWLNE---TGTIGDE KAEMFRNQVTGKIKLLGLVEM--VLLGVGVVMFVAFMISYC-----------------AC RSKNG--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >R_norvegicus_ENSRNOP00000058398 -M-GC----------------------------------------------DLNCGLIT- -------G-------------------------------AIIGAVLAVF--GGI------ -LM-PVGDLLIEKTIKREVVL----EE-GT----IAFKNW-VK---TGTTVYRQFWIFDV QNPEEVAKNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPK D--ST-VSFVQPNG--AIFEPSLSVGT-E--NDNFTVPNLAV------------------ A------AA--------PHIYQN-------SFIQGVL--NNLIKKS---KS-SMFQTRSL KELLW-GYK---------DPFLSLIP---------Y---P------I----STTVGVFYP YNNTV--DGVYKV----------FNGKD-NINK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------K--SYC--DMING--TDAASFPPF----V- EKSRTLRFFSPDICRSIYA-VFES--EVNL-KGIPVYRFVLP-VNAF-ASPLQNP-DNHC F--------------------------------CTEK----------VISNNC--TSYGV LDIGKC--KE---GK-PVYISLPHFLHASPDVSEPIQGLN-PNEDEHR-TYLDVEPIT-- -GFT-LQFA-KRLQVNILVKPARKIE---AL-RNL--KRPYIVPILWLNE---TGTIGDE KVEIFRNQVTGKINLLDLVER--VLLVVGVLMFVAFMISYC-----------------AC RSKNG--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >C_familiaris_ENSCAFP00000009599 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLALL--GGI------ -LM-PVGDMLIEKTIKKEVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNAQEVVANS---SKIKVKQRGPYTY--R---VRY--------------LAKENITHDTE N--HL-VSFVQPNG--AIFEPSLSVGT-E--DDTMTVLNLAV------------------ A------AA--------PHLYPN-------AFVQVVL--NSLIKKS---KS-SMFQNRTV KELLW-GYT---------DPFLSLVP---------Y---P------V----NTKVGVFYP YNNTV--DGVYSV----------FSGKD-NVSQ--VAI-IDTYKGK-------KN----- -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V- EKTRVLRFFSSDICRSIYA-VFGA--EINL-KGIPVYRFVLP-SMAF-ASPLQNP-DNHC F--------------------------------CTEK----------VISNNC--TSYGV LDIGKC--KE---GK-PVYISLPHFLHASPDIGEPIEGLS-PNEDEHT-TYLDVEPIT-- -GFT-LRFA-KRLQINILVKPAKKIE---AL-KNL--KRNYIVPILWLNE---TGTIGDE KAAQFRKQVTGKINLLGLVEI--ILLTVGVVMFVAFMISYC-----------------AC RSKGK--R---------------------------------------------------- ------------------------------------------------------------ --------------------- >P_pygmaeus_ENSPPYP00000020018 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAILAVF--GGI------ -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDPE D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------ A------AA--------SHIYQN-------PFVQVVL--NSLINKS---KS-SMFQVRTL RELLW-GYK---------DPFLSLVP---------Y---P------V----TTTVGLFYP YNNTA--DGVYKV----------FNGKD-NINK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------E--SYC--DMING--TDAASFPPF----V- EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVQNP-DNYC F--------------------------------CTEK----------IISKNC--TSYGV LDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDE KANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC RSKTI--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >P_troglodytes_ENSPTRP00000033093 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDPE D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------ A------AA--------SHIYQN-------QFVQMVL--NSLINKS---KS-SMFQVRTL RELLW-GYR---------DPFLSLVP---------Y---P------V----TTTVGLFYP YNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------E--SHC--DMING--TDAASFPPF----V- EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVENP-DNYC F--------------------------------CTEK----------IISKNC--TSYGV LDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDE KANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC RSKTI--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >B_taurus_ENSBTAP00000023750 -M-GC----------------------------------------------NRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDMLIEKTIKKEVVL----EE-GT----IAFKNW-VK---TGTDVYRQFWIFDV QNPDEVTVNS---SKIKVKQRGPYTY--R---VRY--------------LAKENITQDPE T--HT-VSFLQPNG--AIFEPSLSVGT-E--DDTFTILNLAV------------------ A------AA--------PQLYPN-------TFMQGIL--NSFIKKS---KS-SMFQNRTL KELLW-GYT---------DPFLNLVP---------Y---P------I----TTTIGVFYP YNNTA--DGIYKV----------FNGKD-DISK--VAI-IDTYKGR-------KN----- -----LS--YW-------------------S--SYC--DLING--TDAASFPPF----V- EKTRVLQFFSSDICRSIYA-VFGA--EINL-KGIPVYRFILP-SFAF-ASPFQNP-DNHC F--------------------------------CTEK----------IISKNC--TLYGV LDIGKC--KE---GK-PVYISLPHFLHGSPELAEPIESLS-PNEEEHS-TYLDVEPIT-- -GFT-LRFA-KRLQVNMLVKPAKKIE---AL-KNL--KHNYIVPILWLNE---TGTIGDE KAEMFRNQVTGKINLLGLVEI--VLLSVGVVMFIAFMISYC-----------------AC RSKRV--N---------------------------------------------------- ------------------------------------------------------------ --------------------- >H_sapiens_ENSP00000308165 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNPQEVMMNS---SNIQVKQRGPYTY--R---VRF--------------LAKENVTQDAE D--NT-VSFLQPNG--AIFEPSLSVGT-E--ADNFTVLNLAV------------------ A------AA--------SHIYQN-------QFVQMIL--NSLINKS---KS-SMFQVRTL RELLW-GYR---------DPFLSLVP---------Y---P------V----TTTVGLFYP YNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------E--SHC--DMING--TDAASFPPF----V- EKSQVLQFFSSDICRSIYA-VFES--DVNL-KGIPVYRFVLP-SKAF-ASPVENP-DNYC F--------------------------------CTEK----------IISKNC--TSYGV LDISKC--KE---GR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- -GFT-LQFA-KRLQVNLLVKPSEKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDE KANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC RSKTI--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >E_caballus_ENSECAP00000013084 -M-GC----------------------------------------------DRNCGLIT- -------G-------------------------------AVIGAVLAVL--GGI------ -LM-PVGDMIIQKTIKKEVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNPQEVAVNS---SKIKLMQRGPYTY--R---VRY--------------LAKENITHDSE N--HT-VSFVQPHG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------ A------AA--------AHLYEN-------PFVQVVL--NSLIKKS---KS-SMFQTRTL KELLW-GYK---------DPFLSLVP---------Y---P------V----PTTVGVFYP YNNTV--DGVYQV----------FTGKD-NISK--VAI-INTYKGK-------KN----- -----LS--YW-------------------S--GYC--DMVNG--TDAASFPPF----V- EKTRVLQFFSSDICRSVYA-VFGA--DVNL-KGIPVYRFVLP-SKAF-ASPLQNP-DNHC F--------------------------------CTEK----------IVSKNC--TLYGV LNIAKC--KD---GR-PVYISLPHFLHASPEILESFEGLN-PNEEEHS-TYLDVEPIT-- -GFT-LQFA-KRLQVNILVKPSRKIE---AL-KSL--KRNYIVPILWLNE---TGTIGDE KAKMFRKQVTGKISLLGLVEM--VLLSVGVVMFVAFMISYC-----------------VC RAKKV--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >M_domestica_ENSMODP00000021313 -M-GC----------------------------------------------DRNCGLIT- -------G-------------------------------AVIGGVLAVL--GGI------ -LM-PVGDMIVQNTIKKECVI----ED-GT----IAYKNW-VK---TGTEVYRQFWIFDV QNPEEVMINS---TKLKVKQRGPYTY--R---VRY--------------LAKENLTQNS- D--NT-ISFVQPNG--AIFERRLSVGT-E--NDSFTVLNLAV------------------ A------AA--------PILYPN-------SFVQMVL--NSFIKKS---HS-SMFQVRTL KELLW-GYK---------DPFLSLVP---------Y---P------I----DTTVGVFYP YNNTV--DGVYKV----------YNGKD-DISK--VAI-IDTYKDK-------KN----- -----LS--FW-------------------P--GYC--DMING--TDAASFPPF----V- EKTRILRFFSSDICRSIYA-EFEH--EVNL-KGIPVYRFVLP-SKAF-ASPTVNP-DNDC F--------------------------------CTEK----------IISKNC--TSAGV LDISTC--KD---RK-PVYISLPHFLHASPDVPEPIEGLN-PNEEEHR-TYLDVEPIT-- -GFT-LQFA-KRLQVNILVKPVKKID---TL-SKL--KRNYLIPILWLNE---TGTIGDE KAEMFRKQVTGKISLLGLVEM--VLLTVGIVTFVASMIAYC-----------------VC RSKKV--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >B_taurus_ENSBTAP00000018902 -M-GC----------------------------------------------DRNCGLVT- -------G-------------------------------AVIGAVVALF--GGI------ -LM-PVGDMLIEKTIKKESVL----EE-GT----IAFKNW-VK---AGANVYRQFWIFDV QNPEEVAVNS---SKIKVKQRGPYTY--R---VRY--------------LAKDIISQDSK T--HT-VSFQRPKG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------ A------AT--------PHLYPS-------TFVQIIL--NVFIKNS---NS-FMFQKRTL KELLW-GYK---------DPFLSSVP---------Y---S------I----PTTVGVFYP YNNTA--DGVYKV----------FNGKD-DISK--VAR-IDTYKGK-------KH----- -----LS--YW-------------------P--SYC--GMING--TDGATFPPF----I- EKNRVLQFFSADICRSFYA-VFGA--EINL-KGIPVYRFVLP-SRIF-ASPLQNP-DNHC F--------------------------------CTEK----------IISKGC--TLYGV LDISKC--KE---GK-PVYISLPHFLHASPEIAELIEGLS-PNEEEHS-TYLDVEPIT-- -GFT-LQFA-QRMQINILVKPAKNIV---AL-KDL--KHNYLVPILWLNE---TATIADE KAEIFRNQVTGKINLLGLIEM--ILMSVGAVMFIAFTISYC-----------------AC RLKNA--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >O_anatinus_ENSOANP00000005521 -M-GC----------------------------------------------NRNCGLIT- -------G-------------------------------AVVGAVLAIL--GGV------ -LM-PVGDMIIQKTIKKQGII----EE-GT----VAYKSW-EK---TGTDVYRQFWIFDV QNPDEVRVNN---SKIVVKQKGPYTY--R---VRF--------------LPKENITKNS- D--NT-ISFMQPNA--AIFEPSMSVGS-E--YDTCTVVNLAV------------------ V------AV--------PVLFPN-------AFVQRLL--NSYIKKS---KS-SLFQIRTV KELLW-GYT---------DPFLQLVP---------Y---P------V----DTTVGVFYP YNNTA--DGEYKI----------FTGKD-DISK--VAI-IDTYKDK-------RN----- -----LS--YW-------------------P--GYC--DMINGTETDAASFPPF----L- DKNRVLQFFSSDICRSIYA-KFER--EINL-KGIPVYRYVLP-RMAF-ASPVENP-DNYC F--------------------------------CTEK----------VISRNC--TSAGV LDISSC--KQ---KK-PVYISLPHFLHASLDVTDPVEGLS-PNQEEHQ-TYLDVEPIT-- -GFT-LAFA-KRLQVNLLISPAPLIE---PL-SKL--KRSYITPVLWLNE---TGTIGDE KAELFRAQVIGKINLLGLLQL--VLLILGLATFVSFTIAYC-----------------AC RTKSI--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >G_gallus_ENSGALP00000013734 -M-TC----------------------------------------------NRSCGLLT- -------G-------------------------------AVIGAVLAIF--GGV------ -LI-PVGDNLINRAIKKDAVI----SN-GT----IAYDNW-LV---PGSSVYRQFWIFNV ENPSDVLNFG---ARPKLEQRGPYTY--R---VRY--------------LPKENITENP- N--GT-ISYMLPNA--ARFEPDMSVGT-E--NDTITCLNLAV------------------ V------AA--------PALYKN-------NFIQLLL--NTWIKSS---KS-NMLQNRTV KEILW-GYK---------DPFLNKVP---------F---P------L----DPVLGVFYP YNGTS--DGLYRV----------YTGKE-DISK--TAI-IESYKNK-------RN----- -----LS--YW-------------------E--GYC--DLVNG--TDGASFPPF----V- KKNQVLRFFSSDICRSIYG-VYQT--SKTV-KGIPLYRFTVP-REAF-ASPIDVG-DNYC F--------------------------------CTDQ----------VISQNC--TLAGV LDISSC--KA---GR-PVYISLPHFLHASESILHDVEGLS-PNEEEHE-TFLDVEPTT-- -GFT-LQFA-KRLQVNLLVTPSSKIE---AL-SKV--QKPYVFPILWLNE---SAVIGDE KAEMFRNKVTGRVQLLGVVQM--VLIIAGSVLFLAFMGSYF-----------------IC RSKKL--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >O_cuniculus_ENSOCUP00000002156 ---GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDILIEKTIKKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXX XXXXXXXXXX---XXXXXXXXXXXXX--X---VRY--------------LAKENVTQDPE D--HT-VSFVQPNG--AIFEPSLSVGT-E--NDTFTVLNLAV------------------ A------AA--------PHIYQN-------TFVQVLL--NSLIKKS---KS-SMFQTRTL KELLW-GYK---------DPFLSLVP---------Y---P------I----TTTVGVFYP YNNTX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XN----- -----LS--YW-------------------P--SYC--DMING--TDAASFPPF----V- EKSRVLQFFSSDICRSIYA-VFGS--EINL-KGIPVYRFVLP-AKAF-ASPVQNP-DNHC F--------------------------------CTET----------IISNNC--TSYGV LDIGKC--KE---GR-PVYIKMHHFLHASPDVSEPIEGLN-PNEEEHR-TFLDVEPXX-- -XXX-XXXX-XXXXXXXXXXXXXXXX---AL-KNL--TKNYIVPILWLNE---TGTIGDE KAEMFRKQVTGKINLLGLVEI--ILLSVGVVMFVAFMISYC-----------------AC RTKTV--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >T_guttata_ENSTGUP00000002704 -M-GC----------------------------------------------NRNCGLLT- -------G-------------------------------AIIGAVLAIF--GGV------ -LI-PVGDNLIGKAVKKEAVI----VN-GT----TAFKNW-LV---PGSSVYREFWIFHV LNPSEVMEEG---AHPKLEQRGPYTY--R---VRY--------------LPKENVTEGE- N--GT-ITYMMPNA--ANFEPAMSVGT-E--NDTLTVLNLAV------------------ V------AV--------PSVYPS-------TLMQSVI--NTWVKSS---KA-AILQNRTV KEILW-GYT---------DPFLDSIP---------F---P-----NV----KSFVGVFYP YNGTS--DGPYSV----------YTGAD-DITK--TAV-IESYKHG-------RT----- -----LS--YW-------------------K--GHC--DMVNG--TDGASFPPF----V- KKDQVLRFFSADICRSIYA-VFHS--KQLV-KGITLYRFVVP-REAF-ASPAEVR-DNYC F--------------------------------CTDP----------ELSENC--TIAGL LDISAC--KA---KR-PVYISLPHFLHASESVLHSVEGMS-PNEQEHE-TYLDIEPVT-- -GFT-LRFA-KRLQVNLLVRPSTRIE---PL-KKV--KKPYVFPILWLNE---SAVIGDE KAEMFRTKISSRLELLSMLQM--ALMIGGSVLFLAFMGSYF-----------------IC RSKKL--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >A_carolinensis_ENSACAP00000015615 -M-GS----------------------------------------------CQNVALLS- -------G-------------------------------AVIGAVLAIL--GGA------ -LI-PVGNYFVEETVKKETII----EN-GT----IAFENW-VV---PGSPVFRQFWIFDV QNPEDVMKNG---SQPIVKQKGPYTY--R---IRY--------------LAKENITHHP- D--ST-VSYFQPNI--AQFEPDMSVGP-E--NDTFTMVNLAV------------------ V------AA--------PALYQT-------GFMQALL--NVFIKSS---KS-EFLQTRSV KEILW-GYE---------DPFLKKIP---------I---P-----GV----VKKVGVFYP FNETL--DGLYTV----------YTGRE-DMSK--TAI-IHSYKNK-------SM----- -----LP--YW-------------------G--GYC--DMING--TDGSSFPPF----V- SRNNVLQFFSSDICRSIYG-YFDS--DQLV-KDIPLYRFIVP-PNAF-ASPLVNP-DNIC F--------------------------------CTEQ----------IISRNC--TGAGA LDISAC--KE---GK-PVYISLPHFLYASEEVFLGVEGLQ-PNPKEHM-TYLDVEPTT-- -GFT-LQFA-KRLQVNLLVKPSAKIT---PL-QKI--KEAYLFPILWLNE---TAVIDDK KAEFFRSKVTNKIRLLYLVEA--VLIVVGAVMFLGFMAAYL-----------------IC RVQKS--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >X_tropicalis_ENSXETP00000017231 -M-CC----------------------------------------------STKCWLIV- -------G-------------------------------SVIGGLLAIL--GGI------ -LF-PVGDMIINKEISTEAVI----EE-GT----IAYENW-IE---AGSPVYRHFWIYHV TNPDEII-NG---GKPILQQKGPYTY--RIQSVRY--------------LPKENITQLE- N--NT-VSYWQPNG--AIFQREGSYGP-E--EDTYTVLNLAV------------------ A------AA--------PAMFPA---------LQGLL--NAIIKSS---NS-SLFQVRSV KELLW-GYR---------DPFLEKIP---------I---D-----SI----DKTTGLFYP NNGTA--DGIYHV----------YNGKG-DISK--VAI-IDRYKEA-------KA----- -----LP--YW------------N------D--DFC--DMING--TDAASFPPS----V- KKDKRLYFFSSEICRSIYG-IFEK--EYMV-KGIKLYRFVVT-EDAM-ASPTKNP-DNHC F--------------------------------CKDF----------QLSRNC--TAAGV LDLRSC--QG---GK-PIFLSLPHFLYASDYLLDSVSGLK-PNKEEHE-TYIDVEPIT-- -GFT-MHFA-KRLQVNVMIQPTDKIE---VM-SKL--QSELVFPVAWLNE---TALIGDD SANMFKSKVTTPMKVVEILRI--VLLCVGSVVFLACSITLC-----------------VR GSKKQ--R---------------------------------------------------- ------------------------------------------------------------ --------------------- >T_rubripes_ENSTRUP00000041076 -MGCC----------------------------------------------NVRCGLIA- -------G-------------------------------AVIGAVVAIL--GGI------ -LI-PVGRNIIKGTVEKEAVL----EP-GT----TAHDNW-VS---AGATVYRQFWIFDV KNPQEIVNDG---ATPVVVEKGPYTY--K---TRY--------------LPRDNITYG-- D--IT-VSFVLPAG--AIFIPSMSVGL-E--EDSVTCLNLVV------------------ AVSVAWRSR--------TTMAHF--------VVVVVV--FFAITTI---SKLSLFQHRTV KELLW-GYR---------DPTFFIET---------G-LFV-----SL----PTLSHVLHQ YNGST--DGIYTV----------FTGKD-DISK--VGL-IDSWREK-------KK----- -----LD--FW------------E------D--QYC--DMING--TDASSFPPF----V- DKSKPLYFFSSDICRSVSA-SFQQ--SMDL-KGIEVYRFTLQ-PNTL-AAPTDNP-DNHC F--------------------------------CRDQ----------KVTKNC--SLAGA LDISSC--QS---GK-PIYISLPHFLYGSPILQSNVLGLN-PSEEHHM-TYMDVEPIT-- -GFT-LGFA-KRIQMNMMYGPSQKVK---IF-KKI--KDYTIFPIAWLNE---TAVLDQE TADMFKEQLISRIRMLEMLQY--SLLGIGVSVFVLCLIGFC-----------------VV RNKRG--KL--------------------------------------------------- ------------------------------------------------------------ --------------------- >D_rerio_ENSDARP00000050752 -MTCC----------------------------------------------DQRCALIT- -------G-------------------------------AVLGALIALL--GGI------ -LI-PVGDMIIKNTVHKETVL----EN-GT----LAFDTW-TS---VDIAMYRQFWIFNV ENPDKVLSEG---SKPVLVQKGPYTY--R---VRY--------------IPKTNITFND- N--NT-VSFVLPAG--ATFEPSMSVGS-E--EDVFTSLNLAV------------------ A------GV--------YRLIG-----------PKLA--DWLIRSS---GS-SLFQNRTV KELLW-GYK---------DPMLNS-----------------------------LVGAFYP YNGTV--DGPYTV----------FTGKD-DINK--VAI-IERWQGE-------TS----- -----VN--YW------------N------D--SYC--DKING--SDGSSFHPF----L- DKKEPLYFFSPDICRSISA-EYEA--TVNL-KGIDVYRYLLP-VDAL-ASPVSNP-DNMC Y--------------------------------CTDH----------EITRNC--TLAGL LDITSC--K----GT-PVFISLPHFLYASIELQQGVVGMN-PNLDEHS-IFLDVEPIT-- -GFT-LRFS-KRLQVNMMYGPSDDIA---LL-NKI--KEHTIIPILWLNE---TAVLDDE TAKMFKNELISRMDMLEGLQI--GLLVTGSAIFLGCMIGLI-----------------VV CSKPS--KT-NLS----------------------------------------------- ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000020106 -MGCC----------------------------------------------NRRCGLIA- -------G-------------------------------AVFGAVVTIL--GGI------ -LI-PVGDMIIEETVKKEAVI----EP-GT----IAYDNW-AA---AGVKVYRQFWFFDV QNPSEV-EQG---AKPVLVEKGPYTY--G---TRF--------------LAKENVTFLL- N--DT-VSFLLPQG--AIFEPSMSVGP-E--ADNISCLNLGV------------------ AIFKKQ-GA--------YSLLP-----------HNVL--ELLISAN---KA-SLFQNRTV RELLW-GYK---------DPLLFGMQ----------------------------MGLFSP YNGTY--DGYYNV----------FTGKD-DITK--VSK-IDMYRGN-------SN----- -----LG--FW------------N------D--SYC--DMING--TDASSFAPF----L- DKETPLYFFSSDICRSVSA-SYEQ--TVDL-KGIDVYRYSLL-PSTL-ASPVVNP-DNRC F--------------------------------CKNM----------QTTKNC--TLAGV LELSVC--QQEI-GA-PVYISLPHFLLGSDILRESVVGLN-PHPENHK-TFLDVEPIT-- -GFT-LNFA-KRIQVNMILSHDPDYP---LV-SSLMLSYYMILPVVWMNE---TATLDDE TADMFKNELLGRINMLDIIQK--VLLGAGAAIFVLCLIFYC-----------------FA RRSHK--RS-KTV----------------------------------------------- ------------------------------------------------------------ --------------------- >T_nigroviridis_ENSTNIP00000014345 ---CC----------------------------------------------SVRCGLAA- -------G-------------------------------AALGALVAVL--GGI------ -LI-PVGKTVIRSTVEKEAVL----EP-GT----TAYDNW-VS---ADAPVYRQFWFFHV KNPEEVVKNG---TTPVVEERGPYTY--R---TRY--------------LPKENVTYGN- D--ST-VSFMLPLG--AIFEPSLSVGP-E--DDTVTCLNLVV------------------ A------GA--------YTLVPE--------YLHWVL--DLAIKGT---NS-SLFQRRSV RELLW-GYQ---------DPVLTALT---------G----------R----PDLTGLFVP YNGTA--DGVYTV----------YTGKD-DISK--VGL-IHSWRGN-------RT----- -----VN--FW------------Q------D--RYC--DMING--TDASSFPPF----L- DQTKPLFFFSSDICRSVSA-SFER--SRDL-RGIRVFRYVLL-PETL-AAPVDNP-DNHC F--------------------------------CRDT----------QVTRNC--TLAGA LDISSC--QD---GK-PVYISLPHFLHGSAVLQQNVLGLH-PSPEHHM-TYLDVEPTT-- -GFT-LSFA-KRIQMNMMYGPSQRIT---VL-KKV--KDFTIFPILWLNE---TAELDQE TADMFQQQLFSRVRLLEAVQY--SLLGVGLAAFFLCLVGVL-----------------VA WRKHW--N---------------------------------------------------- ------------------------------------------------------------ --------------------- >G_aculeatus_ENSGACP00000026365 -MGCC----------------------------------------------NRRCGLIA- -------G-------------------------------AVIGAAVAIL--GGV------ -LL-PVGNSIIRETVEKEAVI----EN-GT----TAYDNW-VA---GGVVVYRQFWLFDV QNAEEVVRSG---ATPVVLEKGPYTY--K---TRY--------------LAKENITFNS- N--LT-ASFVLPVG--AIFDPSMSVGP-E--EDTVTSLNLAV------------------ AVS----EP--------YSLVP--------TELHGVL--DKLITTS---KS-SLFQLRTV KELLW-GYN---------DPLFKS-----------------------------QLGLFFP YNGTY--EGSFNV----------YTGKD-DISK--VGM-IDRWRGE-------RS----- -----LH--FW------------N------D--TYC--DMING--TDASSFSPF----V- DKKTPLYFFSSDICRSVSA-SFEA--SHDL-KGIEVYRFALQ-QNTL-DAPNVNP-DNRC F--------------------------------CKNQ----------KTTRNC--TLAGV LDISTC--QD---GK-PIFISLPHFLYGSEYLREDVKGLH-PNKEHHD-TFLDVEPTT-- -GFT-LRFA-KRIQVNMM-----------VL-QKV--RDYTIFPLLWMNE---TAALDDE TAAMIKGELFSRIDMLDILWK--ALLGSGVAVFLVCSISYC-----------------MV RRNDN--QN-FLWCQKENTVILK------------------------------------- -----SS----------------------------------------------------- --------------------- >G_gorilla_ENSGGOP00000005986 -M-GC----------------------------------------------DRNCGLIA- -------G-------------------------------AVIGAVLAVF--GGI------ -LM-PVGDLLIQKTIKKQVVL----EE-GT----IAFKNW-VK---TGTEVYRQFWIFDV QNPQEVMMNS---SNIQVKQRGPYTY--X---XXX--------------XXXXXXXXXXX X--XX-XXXXXXXX--XXXXXXXXXXX-X--XXXXXXXXXXX------------------ X------XX--------XXXXXX-------XXXXXXX--XXXXXXX---XX-XXXXXXXX XXXXX-XXX---------XXXXXXXX---------X---X------X----XXXXXXXXX YNNTA--DGVYKV----------FNGKD-NISK--VAI-IDTYKGK-------RN----- -----LS--YW-------------------E--SHX--DMING--TDAASFPPF----V- EKSQVLQFFSSDICXXXXX-XXXX--XXXX-XXXXXXXXXXX-XXXX-XXXXXXX-XXXX X--------------------------------XXXX----------XXXXXX--XXXXX XXXXXX--XX---XR-PVYISLPHFLYASPDVSEPIDGLN-PNEEEHR-TYLDIEPIT-- -GFT-LQFA-KRLQVNLLVKPSKKIQ---VL-KNL--KRNYIVPILWLNE---TGTIGDE KANMFRSQVTGKINLLGLIEM--ILLSVGVVMFVAFMISYC-----------------AC RSKTI--K---------------------------------------------------- ------------------------------------------------------------ --------------------- >X_tropicalis_ENSXETP00000017237 ------------------------------------------------------------ -----------------------------------------IGGLFAVV--GIV------ -LF-PVNNILNHEAVTKTSVI----EE-GT----AAFDNW-VL---PRSPVYRSFWIYHV RNPNDII-NG---GKPELQQKGPYTY--L---VRR--------------IPKLGITQHE- N--FT-MSYLQYND--AIFQRHMSVGS-E--EDTHTVLNVAV------------------ A------ST--------PDMFPD---------YHEIL--NTAITNS---SS-SLFQVRTV KELLW-GYN---------DPFLEQIP---------F---P-----DI----DTTTGVFYP ------------A----------FFTYL-NLLR--KHE-VQVAKGL-------WS----- -----LS--YW------------N------G--DNC--NMING--TDAFLFSPF----N- KKKNHLFFFSPDACRSLYG-VFEK--EYDL-KGIKMNRFVVP-KEVF-ASSAENS-DNHC F--------------------------------CKDM----------KVTRNC--TADGI LELRAC--RD---RK-PIFLSLPHFLHGSQFLLDAVGGLK-PNEYEHR-SYIDVEPVS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >T_guttata_ENSTGUP00000001744 ---------------------------------------------------MKSLCLVTV -------------------------------------GVLAMTLLIASI--SLL------ -VA-HVFQTVVDLQVKQGTVL----KN-GT----ETFEAW-ED---PPPPVYMQFYFFNV TNPLEVLQG----ATPLVEEIGPYTY--R----EY--------------RPRVHVQFLD- N--GTKVSALNPKT--YVFEPEKSVGDPE--VDLIRTVNIPA------------------ V------TA--------MEWTRST-------PLQFAT--EVLLLLY---QE-SLFTVRSV HQLLW-GYK---------DRLLSTIH---------V-LHP-----EI----DPVFGLFNK MNGTD--DGEYVF----------LSGET-NYLN--FSR-IVEWKGK-------ES----- -----LS--WW------------T------T--EAC--NMING--TDGTSFHPL----I- SKDENIYIFSSDFCRSLFL-VYDS--SGDV-AGVPTFRFVPS-SMVF-ANTSVNP-ANAG F--------------------------------CVP-------------AGNC--PGTGV LNVSVC--KQ---GA-PIFLSAPHFYQADPKFVEDIEGMH-PRKEYHE-TFLDINPLT-- -GLV-LRAA-KRMQVNVHVRKLPEFF---ET-GNI--R-TLIFPVMYINE---SVLIDEA SASKLRH-VLLEASVVTGIPF--VIMALGIVFGIVFIVLVC-----------------RS QRITE--ES-TEEERSPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >X_tropicalis_ENSXETP00000052043 ---------------------------------------------------MVKWAVFGT -------------------------------------AAVSVTLLIVSI--VLL------ -LT-HTFMDIVEGQVKQAIVL----KN-ES----EVFEDW-AN---PPPPVYMQFYFFNV TNPLEVLSG----EKPFVDEIGPYTY-------EY--------------RPRENITFSV- N--GTEVSAVTPKT--YVFEPEKSIGDPK--VDLIRTVNIPL------------------ V------TI--------LEMTKDSS------LLRLFI--IAALKTY---KE-GMFVTRTV DELLW-GYK---------DAVLSILH---------P-FKK-----NI----SDTFGLFYK MNTTD--DGEYIF----------LSGEK-DYLE--FTQ-IAEWKGQ-------KA----- -----LN--WW------------T------T--ETC--NMING--TDGTSFHPL----L- NKDDTIYMFSSDLCRSIYA-VYES--SENI-KDISVFRFSPP-ASVF-ANVSVNP-QNKG F--------------------------------CVP-------------EGNC--LPSGL LNVSIC--KE---GA-PIVLSSPHFYQADENVINSIRGMK-PVKEHHM-TFLDLNPLT-- -GTL-IQAA-KRMQVNVYVRKINVYP---IT-QDI--Q-TLFFPVMHLNE---SVLIDDK SAGRLRS-ILFQGRVVANIPF--IIMGLGIILAFLFTTLSC-----------------LQ KRSRD--EG-TEEERGPLIRAS-------------------------------------- ------------------------------------------------------------ --------------------- >M_mulatta_ENSMMUP00000027514 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNV TNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANVQFGD- N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------ L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYE KNGTN--DGDYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I- TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNKEDHE-TFVDINPLT-- -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVLIDKE TASRLKS-VINTTLIITNIPY--IIMALGVFFGFVFTWLAC-----------------KG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >G_gallus_ENSGALP00000018715 ---------------------------------------------------MRSLCLVTV -------------------------------------GVLALTLLIASI--SLL------ -VA-HVFQTVVDLQVKQGTVL----KN-GT----ETFEAW-ED---PPPPVYMQFYFFNV TNPLEVLQG----ATPLVEEKGPYTY--R----EY--------------RPRVHVQFLD- N--GTKVSALNPKT--YVFEPEKSVGNPE--VDLIRTINVPA------------------ V------TA--------MEWTRAT-------SLQFAT--EVLLLLY---QE-SLFTVRTV HELLW-GYK---------DKLLSTIH---------V-LHP-----EI----DPVFGFFNK MNGTD--DGEYVF----------LSGEM-NYLN--FSR-IVEWKGK-------ES----- -----LN--WW------------T------T--KTC--NMING--TDGTSFHPL----I- SKDENIYIFSSDFCRSLYL-VYDS--SGSV-AGVPTYRFVPS-PMVF-ANTTVNP-DNAG F--------------------------------CVP-------------PGNC--PGAGV LNVSIC--KQ---GA-PIFLSAPHFYQADQKFVSDIEGMH-PTKEYHE-TFVDINPLT-- -GLV-LQAA-KRMQINIHVRKLPEFF---ET-GNI--R-TLIFPVMYINE---SVLIDEA SANKLKH-VLLEASVVTGIPF--VIMAIGIVFGIVFSVLVC-----------------RA QGARE--ES-TEEERSPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >G_aculeatus_ENSGACP00000022821 -------------------------------------------------MQLKSCCIYSI -------------------------------------GVFSILLLISGI--VLV------ -LS-NVFPLLTQSLVEKEVVL----KN-GT----EAFEAW-KN---PPAPIYMQFYFFNL TNPLEVLDG----DRPAVVEIGPYTY--R----EY--------------RPMEQVDFQD- N--GTKVAAVNTKT--YIFQPNMSRG-PE--SELIRTVNIPA------------------ M------TV--------MEQFKDQP------LIANLI--AAYMRSA---DE-GLFSTHTV GELLW-GYE---------DALLKALK---------T-LKP-----DL----DDVFGLFHK NNGSN--DGQYVF----------FTGHQ-SYQD--FAR-VDTWNGD-------RS----- -----LS--WW------------T------S--DEC--NMING--TNGASFHPV----I- AKNETLYMFSSDLCRSLYA-VYEE--DVTV-KGIPAYRFSPP-SDVF-ANHTVNP-ANAG F--------------------------------CVP-------------IGNC--LGSGV LNVSPC--KQ---GA-PIVMSSPHFYQADEKYVQGVFGMR-PQKEQHQ-TVIDINPFT-- -GII-VQAA-KRLQINVFVEKIPGFS---ET-GNA--R-TVLIPVVYLNE---SALIDDA SAAKLHK-IIVQQNVVVNIPF--LFIGLAIILGGVFMFLMC-----------------RQ KVPED--KG-KKNERGPILCLS-------------------------------------- ------------------------------------------------------------ --------------------- >H_sapiens_ENSP00000264896 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNV TNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------ L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYE KNGTN--DGDYVF----------LTGED-SYLN--FTK-IVEWNGK-------TS----- -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I- TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNQEDHE-TFVDINPLT-- -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKE TASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000012225 ---------------------------------------------------LKTCCVYGT -------------------------------------GVFSMLMLIVGI--ALV------ -LS-GVFPHLLQSFVETEVVL----KN-GT----DAFEAW-AD---PPAPIYMQFYFFNL TNPEEVLKG----ERPAVVELGPYTY--R----EY--------------RPMEEVAFLE- N--GTKVAAVNTKT--YIFQLNMSRG-PE--SDLIRTVNIPA------------------ V------TV--------MEMFKDST------LEANLI--SAYMRSS---GE-GLFSTHTV GELLW-GYE---------DGLLKALK---------L-FRP-----EL----DDVFGLFYK TNASN--DGQYVF----------FTGQQ-SYED--FAR-VSTWNGE-------SS----- -----LN--WW------------T------S--KEC--NMING--TNGASFHPV----I- TKNELLRIFSSELCRSLYA-VYED--DVSV-KGIPGYRFILP-SEVF-ANESVNP-ANAG F--------------------------------CVP-------------AGNC--LGSGL LNVSAC--KQ---GA-PIIMSSPHFYQADAKYVQSVFGMK-PVKEQHE-TTIDVHPLT-- -GFL-LQAA-KRLQINVYVEQIETFS---QT-GNV--R-TLIFPVVYLNEEHQSVLIDDA SVQKLHV-VVVEKNVLENIPF--ILIGLGILLGGIFMIAMC-----------------RQ KVPES--TS---AERQPLLSS--------------------------------------- ------------------------------------------------------------ --------------------- >O_anatinus_ENSOANP00000014317 ------------------------------------------------------------ ------------------------------------------------------------ ----------------QNVVL----KN-GT----DAFESW-EK---PPPPVYMQFYFFNV TNPSEALRG----ETPEVEEVGPYTY--R----EH--------------RPRENIRFWD- N--GTKVSAINPKT--YIFERDLSVGDPA--VDLIRTVNIPA------------------ V------TA--------MRWSQNR-------FLKEII--EGILKGF---QQ-SLFVTHSV HELLW-GYK---------DEVLSLIN---------A-FRP-----DV----PQYFGLFYG KNATD--DGEYVF----------LSGED-DYLN--FSR-IVEWKGR-------TS----- -----LD--WW------------A------T--KKC--NMING--TDGNSFHPL----I- TKDEDLYIFSSDFCRSVYV-GFTD--SVDV-RGIPAFRFKMP-RELL-ANNS----DNAG F--------------------------------CGP-------------QGRC--LGSGV LNVSVC--KD---GV-PIFLSAPHFYQADEQFVAAVKGLR-PEKASHE-TFLDIDPVT-- -GMI-LRAA-KRFQVNVFVQQIDGFI---ET-GNI--K-TTLFPVMYLNE---SVLIDED SVKKLRS-VLNTMMVITNIPY--IIMALGAFLGLLFTWMAC-----------------RG QGSMN--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >P_troglodytes_ENSPTRP00000027814 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNV TNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------ L------TV--------IEWSQVR-------FLREII--EAMLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYE KNGTN--DGDYVF----------LTGED-SYLN--FTK-IVEWNGK-------TS----- -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I- TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PNKEDHE-TFVDINPLT-- -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKE TASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >M_domestica_ENSMODP00000037525 ------------------------------------------------------------ ------------------------------------------------------------ -------------SLPQNIVL----KN-GT----EAFDSW-EN---PPPPVYMQFYFFNV TNPDEILQG----EDPRVEEVGPYTY--S----EL--------------RTTALVEVGE- G--GKEYDSCNQLTPDYVFQRDLSVGDPE--VDLIRTLNIPA------------------ I------TA--------MEWTTNN-------VLKEIL--EGLLKTY---QQ-KLFVIHTA HDLLW-GYK---------DELFSLIS---------I-FKP-----DI----SPYFGLFYG RNGTD--DGDYLF----------LTGED-NYLN--FTK-IVEWNGK-------RS----- -----LS--WW------------A------A--EKC--NMING--TDGNSFHPL----I- SKDETLYIFASDFCRSVYL-KFSD--MGNV-EGIPSLRFTVP-PEMF-ANNS----DNSC F--------------------------------CNP-------------SGNC--LGSGV LNISVC--KN---GA-PIFLSSPHFYQADKKFISAIRGMN-PNKEDHE-TFLDINPLT-- -GII-LRGS-KRLQVNIYVRHIDGFD---ET-GNI--K-TLVFPVMYLNE---SVLIDKD SATKLKS-VINTTMVITNIPY--IIMALGVFLGLIFTWMAC-----------------KG QGSAE--EG-TADERAPLMRT--------------------------------------- ------------------------------------------------------------ --------------------- >P_pygmaeus_ENSPPYP00000016592 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQSIEKKIVL----RN-GT----EAFDSW-EK---PPLPVYTQFYFFNV TNPEEILRG----ETPRVEEVGPYTY--R----EL--------------RNKANIQFGD- N--GTTISAVSNKA--YVFERDQSVGDPK--MDLIRTLNIPV------------------ L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYE KNGTN--DGDYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I- TKDEVLYIFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---GA-PIIMSFPHFYQADERFVSAIEGMH-PKKEDHE-TFVDINPLT-- -GII-LKAA-KRFQINIYVKKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVHIDKE TASRLKS-VINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >T_rubripes_ENSTRUP00000042953 -------------------------------------------------MTRRSCAIYA- ---------------------------------T---GIVSAHLLIVGI--ALV------ -VA-QVFQTMIHERLKKEFTL----TE-AS----QVFESW-KN---PPPPVYMEYYFFNV TNPKEFLAG----GKAAVQQIGPYTYRHR----EY--------------RPRENISFLE- N--GTKIYALNPKS--FVFVPEKSVGNPE--VDIVRTVNIPF------------------ V------AV--------MNELSSYS-----FFLRTGI--SMYIKSL---GV-DLFLTRTV HEVLW-GFK---------DPLLTKLH---------T-MRP-----EV----DEYFGLMWK KNGTH--EGEFVF----------HTGVE-NYLD--YGK-IDTWNGM-------RK----- -----MN--WW------------S------S--NQS--NMING--TDGAVFHPL----I- NRNELLYIFAADLCRSIHL-AYVE--DVEV-KGIQAYRFAPP-SDVL-MSPKENP-TNEG F--------------------------------CVP-------------AGDC--LGTGV LKVSVC--RE---GA-PIVVSFPHFYQADPMYINAIDGLS-PNKDEHE-TYLDLQPTS-- -GVP-IRAC-KRAQLNIILKRVQGFP---ST-RFL--N-ETIFPIMFVNE---TATIDDD SASQMRT-LLLIVTLVSNFPL--LIVGMGIILLLVLVVLFC-----------------RN RQKKS--EV-KRIDFTEAFHS--------------------------------------- -----LTTTKDETAYTQVSDKPDDPSQSATSQPKRNGSYIAMSPVEAQKC---------- --------------------- >R_norvegicus_ENSRNOP00000003052 ---------------------------------------------------MARCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQTIEKNMVL----QN-GT----KVFDSW-EK---PPLPVYIQFYFFNV TNPEEILQG----EIPLLEEVGPYTY--R----EL--------------RNKANVQFGE- N--GTTISAVTNKA--YIFERNQSVGDPT--VDLIRTINIPL------------------ L------TV--------VEMAQQP-------FLREII--EAMLKAY---QQ-TLFVTHTV HELLW-GYK---------DEVLSLVH---------I-FRP-----DV----SPNFGLFYE RNGTN--DGEYVF----------LTGED-NYLN--FTK-IVEWNGK-------TS----- -----LD--WW------------T------T--DTC--NMING--TDGDSFHPL----I- SKDETLYIFPSDFCRSVYI-TFSS--FENV-EGLPAFRYKVP-AEIL-ANSS----ENAG F--------------------------------CIP-------------EGNC--MDAGV LNVSIC--KN---GA-PIIMSFPHFYQADEKFVSAIKGMR-PNKEEHE-SFVDINPLT-- -GII-LRGA-KRFQINTYVKKLDDFV---ET-GNI--R-TMVFPVMYLNE---SVLIDKE TASQLKS-VINTTLIVTNIPY--IIMALGVFFGLIFTWLAC-----------------RG QGSTD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000001610 ------------------------------------------------------------ ------------------------MGVNKARLTA---GFIVAGVLMVFF--GTV------ -LV-FVGPIIIDDQVEKNTMI----DPKND----MSYTMW-KD---LPVPFFMSVYFFNV LNPEEVL-KG---EKPMVEQRGPYVY--R----KR--------------CQKENITFHP- N--YT-VSYREYRT--YYFEPSMSVGN-E--SDLVTVPNMLV------------------ L------SA--------AVMMENLP-----YALRLLI--SATFKTF---KE-GPFLTKTV GELMW-GYD---------SKLVDFLN---------Q-YLP-----GMLP-SSGKFGLFAE FNNSN--TGLFTI----------NTGKD-DIRK--VHR-VDSWNGL-------TQ----- -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M- TKESTLPFYSPDACRSLEL-VYQR--TGEM-LGIPLYRFVAP-RTMF-ANGSQYE-PNQG F--------------------------------C-----------------PC--RQSGL LNVSSC--RH---NS-PVFISHPHFFNADPVLQDYVLGLN-PTEEEHG-LFIDIHPLT-- -GVP-LNVS-IRLQLNLYIKSVSGIT---ET-GKI--S-EVVMPLLWFEE---SGYIDGP VLNTFRTNLVVLPTVMEYMQY--LLIALGLVTVVVASVVHH-----------------KV KNGRR----GSRKDSNPQPAGQK------------------------------------- -----TQNPSAGSALVPAE----------------------------------------- --------------------- >D_rerio_ENSDARP00000023056 -------------------------------------------------MTRRSCTIYA- ---------------------------------T---GIVCAHLLILGI--ALL------ -LA-QVFQTMIQERIKKEITL----AE-NS----RVLDGW-IN---PPPPVYMQYFFFNV TNPDEFLAGK---EKAKVTQMGPYTY--R----EY--------------RPRENVTYLE- N--GTKIFATNPKS--FVFLRNMSAGDPE--VDRVTTVNIPM------------------ I------AV--------MNELNSYS-----FFVRTAV--SMYMGSM---GM-GLFMNRTV HEILW-GFK---------DPLLTKLH---------A-MRP-----EV----DEHFGLMYN KNGTH--EGEFVF----------HTGEK-NYMN--YGK-IDTWNGI-------SQ----- -----MN--WW------------S------S--NQS--NMING--TDGSVFHTF----L- SRKELLYIFAADLCRSIHL-GYVR--DMEV-KGIPAFRFAPP-SDVL-APPDENP-ANAG F--------------------------------CVP-------------AGDC--LGKGV LKVSVC--RQ---GA-PIVVSFPHFYQADERYINAIEGMN-PNEEEHE-TYLDINPTT-- -GVP-IRAC-KRAQLNIILKRVRGFP---NT-KFL--N-ETIFPIMYVNE---TATIDDE SAAQMRM-LLLIVTVVSNFPV--IILALGVILLVVLIFLVC-----------------RN RQRKN--EV-KRIDFTEAFHS--------------------------------------- -----FATTKDETAYTQVSNQAEDSPENRNNQPLRNGSYIAMSPVEAQKC---------- --------------------- >P_troglodytes_ENSPTRP00000009553 ------------------------------------------------------------ ----------------------MGCSAKARWAAG---ALGVAGLLCAVL--GAV------ -MI-VMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDV MNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------ L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAE LNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M- TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGE TLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS QEKCY--L----FWSSSKKGSKD------------------------------------- -----KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- --------------------- >H_sapiens_ENSP00000261693 ------------------------------------------------------------ ----------------------MGCSAKARWAAG---ALGVAGLLCAVL--GAV------ -MI-VMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDV MNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------ L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAE LNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M- TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGE TLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS QEKCY--L----FWSSSKKGSKD------------------------------------- -----KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- --------------------- >M_musculus_ENSMUSP00000031377 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQTIEKNMVL----QN-GT----KVFNSW-EK---PPLPVYIQFYFFNV TNPEEILQG----EIPLLEEVGPYTY--R----EL--------------RNKANIQFGE- N--GTTISAVTNKA--YVFERNQSVGDPN--VDLIRTINIPL------------------ L------TV--------VDLAQLT-------LLRELI--EAMLKAY---QQ-KLFVIHTV HELLW-GYK---------DEILSLVH---------I-FKP-----DV----SPNFGLFYE RNGTN--DGEYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- -----LD--WW------------T------T--DTC--NMING--TDGDSFHPL----I- SKDEVLYLFPSDLCRSVHI-TFSS--FENV-EGLPAFRYKVP-AEIL-ANTS----ENAG F--------------------------------CIP-------------EGNC--MDSGV LNISIC--KN---GA-PIIMSFPHFYQADEKFVSAIKGMH-PNKEEHE-SFVDINPLT-- -GII-LRGA-KRFQINTYVRKLDDFV---ET-GDI--R-TMVFPVMYLNE---SVLIDKE TANQLKS-VINTTLVVTNIPY--IIMALGVFFGLVFTWLAC-----------------RG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000008151 -------------------------------------------------MTRRSYALYA- ---------------------------------V---GGICGTLLAVGI--GLL------ -VG-RVFHTLMENRLKKEIVL----VE-GS----RVFESW-KN---PPPPVFMEFFFFNI TNAEDCLNG----AKPKVTQIGPYTY--R----EY--------------RYKDNVTMVE- N--GTMVSAYTMKK--FVFLREKSVGDPA--VDNITTVNIPS------------------ W------AV--------MEKMKDS-------WFRTVV--SMFMKTL---GS-GPFTSRTV HELLW-GYE---------DPLLEKAA---------G-YTP-----GL----DKAFGLMYK KNGSD--SGEFIY----------HTGEQ-NYLD--YGR-VKTWKGQ-------SK----- -----LT--FW------------T------S--EES--NRIQG--SDGSSFHPL----L- KKDERIYIFTPDLCRTIYM-DFEK--EVEV-KGIPAYRFTPP-RSVF-ASKEENS-DNEG F--------------------------------CVS-------------KKEC--LGTGV LKVSPC--RK---GA-PVVASFPHFYLAEDKYVDAIEGMS-PDREHHQ-TYLDLNPTT-- -GVI-LRAS-KRAQVNILMNRVGGFP---DT-KNL--N-ETVFPVMFLNET-QSVVIDDE SAAKVKK-LLLISDLVSNFAL--FIVGLGGIMLIILVVLLF-----------------RA HQKKN--EV-NRIVFTKALYA--------------------------------------- -----QPSAQDDTSYCPVGDKGREDPQN-------------------------------- --------------------- >T_nigroviridis_ENSTNIP00000018658 -------------------------------------------------MTRRSCAIYA- ---------------------------------TVVAALIVVVVLIAGI--ALA------ -GA-QFFQTLIHERLKKEITL----TE-AS----QVFESW-KN---PPPPVYMEYYFFNV TNPEEFLAG----GKAAVQQIGPYTYRNR----EY--------------RPRENISFLE- N--GTKIYALNPKS--FVFVPEKSAGNPE--VDIVRTVNIPY------------------ V------AV--------MNELSSYA-----FLLRTLI--SMYIKSI---GV-EIFMTRTV HEVLW-GFK---------DPLLTKLH---------S-MKP-----EV----DEYFGLMWK KNGTH--EGEFVF----------HTGVE-NYLD--YGK-IDTWNGM-------RK----- -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I- NRNELLYIFAADLCRSIHL-AYVK--DVEV-KGIQAYRFAPP-SDVL-MSPKDNP-TNEG F--------------------------------CVP-------------AGDC--LGTGV LKVSVC--RE---GA-PIVVSFPHFYQADPMYINAIDGLS-PNKEEHE-TYLDLQPTT-- -GVP-IRAC-KRAQLNIILKRVQGFP---NT-RHI--N-ETIFPIMFVNE---TATIDDD SASQMKT-LLLIVTIVSNFPW--LIVGISVLLLLIM-VLFY-----------------RN RQKKN--EV-KRIDFNEAFHS--------------------------------------- -----LTTAKDETAYTQVSDKPDDSSQTATTQPKRNGSYIAMSPVEAQKC---------- --------------------- >G_gallus_ENSGALP00000004761 ------------------------------------------------------------ --------------------ALRAMVAAGRRVAV---GLGAVGAVCLLL--GGC------ -LL-LAGPAIVKEQVLKNVRI----DP-SS----ISFNMW-RD---IPVPFYLTVNLFEV QNPQEVL-QG---AKPKVNQRGPYVY--R----EF--------------KYKTNITFHD- N--DT-VSYLEYRQ--LFFRPDLSNGT-E--DEYIVMPNILM------------------ L------GA--------AVMMENLP-----SFVKLLL--SGALAGL---KQ-EAFINRTV GEILW-GYE---------DPLLDTIN---------A-LVP-----GLIP-YKGKFGIFIE FNNTN--SGLFTV----------NTGMK-NISQ--VHM-VDSWNGL-------KK----- -----VN--YW------------R------T--NEC--NMING--TAGEMWPPY----M- SP-TSLEFYSPDACRSMTL-VYEQ--SGKF-KGVPTYRFVAP-KTLF-ANGTDYP-PNEG F--------------------------------C-----------------PC--RQSGI QNVSSC--RL---NA-PMFISHPHFYNADPSLVDAVEGLH-PSREEHA-LFLDVHPVT-- -GIP-MNCS-IKLQLNQYMKQVSGIL---QT-GKI--Q-PVVMPLLWFAE---SGYIDGS VLSQFYTNLVLIPSILDYLQY--IFLGLSVPLIISAALVMM-----------------SQ KSSKE--KH-PHDPTTQSPPPQP------------------------------------- -----SETTPLL----QDTGTQSQDTAEA------------------------------- --------------------- >T_rubripes_ENSTRUP00000019814 ----------------------------------------------VCSVTMKRCCTYTL -------------------------------------GVVSILLLVAGI--SLV------ -LS-KVFPRFVHSMVEKEVVL----KN-DT----DAFEAW-EN---PPAHIYMQFYFFNV TNPLEVLSG----ERPAVVEVGPYTY--R----EY--------------RPMEEVAFQE- N--GTKVAAVNTKT--YIFQPEMSRG-PE--SDLIRTINIPA------------------ V------TV--------MKKFQNV-------FLANLV--SAYMRTL---GV-GLFTTRTV GELLW-GYQ---------DNLLASLQ---------K-FQP-----QL----DDVFGLFYK SNASN--DGQYVF----------FTGEL-NYRD--FAR-VDTWNGE-------SS----- -----LN--WW------------S------T--AEC--NMING--TIGASFHPV----I- TKDEMLYIFSSDMCRSLYA-IYEE--DVVV-KGIPAYRFSPP-SEVF-GNTT----ANAG F--------------------------------CVP-------------LGNC--PGSGL LDVSTC--KQ---GA-PIVLSSPHFYQAEEKFVEAVFGMK-PNKEQHQ-TTIDVNPLT-- -GVV-LRAA-KRLQVNVHVEKLPHYS---ET-GDV--R-TLIFPVVYLNE---SALVDDD AAQKLQG-VVRVQEVVVQVPF--MLIGLGFLLGLVFVFLMC-----------------RQ KLPST--PGLLLSPRAPLRSDSRCSPLKAPSQ---------------------------- ------------------------------------------------------------ --------------------- >B_taurus_ENSBTAP00000014549 ---------------------------------------------------MGRCCFYAV -------------------------------------GTLSLLLLVTSI--TLL------ -VA-RVFQKAVDQTIEKNIVL----RN-GS----ETFDSW-KK---PPLPVYTQFYFFNV TNPEEILNG----ETPRLEEVGPYTY--R----EL--------------RNKDDIQFGD- N--GTTISAVSNKA--YVFERDKSVGDPK--IDLLRTLNIPA------------------ L------TA--------MEWTQLP-------LLRDII--EALLKAY---RQ-KLFVTHTV DELLW-GYK---------DEILSLIN---------T-FKH-----DV----SPYFGLFYG KNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- -----LD--WW------------T------A--DEC--NMING--TDGDTFHPL----I- TRDEVLYVFPSDFCRSVYI-TFSD--FESV-QGLPALRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------KGNC--LGSGV LNVSVC--KN---GA-PIIMSFPHFYQADEKFVSAIGGMH-PNKEYHE-TFVDINPLT-- -GII-LRAA-KRFQINVYVRKLDDFI---ET-GNI--Q-TLVFPVMYINE---SVLIDKE TASRLKS-VINTTLIVTNIPY--IIMALGVFFGLIFTWLAC-----------------RG QGSTD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >T_nigroviridis_ENSTNIP00000016587 ------------------------------------------------------------ --------------------------VNKSKVAV---GFIVLGVLAVVF--GVI------ -LA-FVGPIIIDDQIVKNTVI----DPKNE----MSYTMW-KD---VPVPFFMSVYFFHV LNSKEIL-KG---EKPMVEQRGPYVY--R----KR--------------IQKENITFHP- N--NT-VSYREYRS--YYFEPTMSVGN-E--SDVVTIPNMLV------------------ L------GA--------SVMLEKLP-----IHVRMLI--SIGFKLC---KE-GPFLTKTV GELMW-GYD---------SKLVDFLN---------K-YLP-----GMLP-SSGKFGLFTE FNNSN--TGLFTV----------HTGKD-DIRK--VHK-VDSWNGL-------TE----- -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M- TEESTLPFYSPDACRSLEL-VYQR--SGEM-KGIPLFRFVAP-KTLF-ANGSDYA-PNEG F--------------------------------C-----------------PC--RQSGL LNVSSC--RH---NS-PVFISHPHFFNADPVLQDYVQGLS-PNEEEHG-LFIDIHPQT-- -GVP-LNVS-IRLQLNLYMKAVAGIT---ET-GKI--S-EVVMPMLWFEE---RGYIDGP ILTTFHTNLVVLPAVMEYMQY--GLIALGLATIIIAAIVHH-----------------RV KRNKR----GGGATSEGEARASA------------------------------------- -----EEKDPLLQDDVD------------------------------------------- --------------------- >E_caballus_ENSECAP00000022283 ------------------------------------------------------------ ------------------------------------------------------------ -----------------NVVL----RN-GS----ETFNSW-KN---PPLPVYSQFYFFNV TNPEEILRG----ETPRLEEVGPYTY--R----EL--------------RNKADIEFGD- N--G-TISAVSNKA--YVFERNQSVGDAK--TDLIRTLNIPA------------------ L------TA--------MQLAQLH-------ILRELI--EALLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIN---------I-FKP-----DI----SPYFGLFYG KNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- -----LD--WW------------T------T--DRC--NMING--TDGDSFHPL----I- TRDEVLYVFPSDFCRSVYI-TFSD--FESV-RGLPALRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---GA-PIVMSFPHFYQADEKFVSAIDGMH-PNKDYHE-TFVDINPLT-- -GVI-LRAA-KRFQINVYVRKLDEFS---ET-GNI--R-TLVFPVMYINE---SVLIDQE TASRLKS-VINTALIITNIPY--IVMALGVFFGLIFTWLAC-----------------RG QGSLD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >O_anatinus_ENSOANP00000002110 ------------------------------------------------------------ ----------------------MARKLGGCRAPA---VVGLLGLACTVF--GIV------ -MV-FVVPILIKQQIHKNVRI----DP-NS----LSYNMW-KV---IPVPFYLSVHFFEV LNPNQIL-KG---EKPSVRERGPYVY--R----EF--------------RHKDNITFND- N--DT-VSYLEYRS--FRFQPEMSQGS-E--DDYIVIPNILV------------------ L------GS--------SIMMERMP-----LPLKWLM--SSSFNSF---NE-HAFMNRTV SEIMW-GYE---------DPFVEFLN---------K-YLP-----GMIP-FKGKFGLFAE LNNSN--SGLFTV----------YTGVK-DFSK--IHL-VDKWNGL-------SK----- -----VN--YW------------R------S--DQC--NMING--TSGQMWAPF----M- TPKSSLEFYSPEACRSMKL-VYEQ--SRDF-NGIPTFRFVAP-KTLF-ANGTVYP-PNEG F--------------------------------C-----------------PC--LQTGI QNVSTC--RF---SA-PLFLSHPHFYNADPVLVEAVNGLH-PNKEQHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYIKAVRGIM---QT-GKI--Q-PVVLPMLWFGE---SGMMGGK TLKTFYTQLVLMPSVAQYVQY--VFIGLGGVLLIISFILQV-----------------RS QDKCF--L----FWSSSKKGPKN------------------------------------- -----KEAIQVY----SE--TLMTSTHNGTVLQEARL----------------------- --------------------- >T_nigroviridis_ENSTNIP00000002999 ---------------------------------------------------MRQCCFYCL -------------------------------------GLAAVLLLLAGI--VLV------ -LS-GVFPRFLQSRVKKEVVL----KN-AT----DAFEAW-ED---PPAQIYMQFYFFNV TNPLEVLDG----ERPAVVEVGPYTY--R----EY--------------RPMEEVTFQA- N--GTRVAAVNTKT--YIFQPEMSRG-PE--SDPIRTLNIPA------------------ V------TV--------MERFRKS-------WEAELI--SPYMRSL---GV-GLFTTRTV GELLW-GYE---------DSLLRVAK---------K-FWP-----QL----DDVFGLFYK SNASN--DGRYVF----------FTGEQ-DYRD--FAR-VDTWNGE-------SS----- -----LA--WW------------S------T--DEC--NMING--TTGASFHPV----V- TKGEKLYMFSSDLCRSLYA-VYEE--DVTV-KGIAAYRFSPP-SEVF-ANTT----ANAG F--------------------------------CVP-------------PGNC--PGSGL LDVRVC--KS---GA-PIVMSSPHFYQAEEKFKEAVFGMR-PDKQLHQ-TAIDIHPLT-- -GVV-LQAA-KRLQINVHVEKIPHYS---QT-GNV--R-TLVFPVVYLNE---SALIQDA AARKLRA-VVTVQQVVVQVPF--MLMGLGFLLGLVFTVLVC-----------------RH RTPQHTPPESTAAERQPLLSS--------------------------------------- ------------------------------------------------------------ --------------------- >T_rubripes_ENSTRUP00000047691 ------------------------------------------------------------ ------------------------MAINKSKVAV---GFIVVGVLTVFF--GTL------ -LT-FVGPLIIDDQVVKNTVI----DPKNE----MSYTMW-RD---VPVPFFMSVYFFHV LNPKEIL-AG---EKPMVEQRGPYVY--R----KR--------------IQKDNITFHP- N--ST-VSYKEYRS--YYFEPSMSVGN-E--SDVLTIPNMLV------------------ L------GA--------AVMLESLS-----VPVRMII--SMAFKTF---DE-GPFLTKTV GELMW-GYD---------SKLVNFLN---------K-YLP-----GMLP-SSGKFGLFSE FNNSD--TGLFTI----------HTGKD-DIRN--VHK-VVSWNGL-------TE----- -----LS--YW------------R------T--PQC--NMING--TAGQMWPPF----M- TEESTLPFYSPDACRSLEL-VYQR--SGKM-KGIPLYRFVAP-KTLF-ANGTDYS-PNEG F--------------------------------C-----------------PC--RQSGL LNVSSC--RQ---NS-PVFISHPHFFNADPVLLDYVHGLS-PNEEDHG-LFIDIHPLT-- -GVP-LNVS-IRLQLNLYMKRVRGIT---ET-GKI--S-EVVMPMLWFEE---RGYIDGP ILNTFHTNLVVLPAVMEYMQY--GMIALGLATIIIAAFVRY-----------------RF KRHKC----GGGATSKGEASASA------------------------------------- -----GEKDPLLQDDVD------------------------------------------- --------------------- >T_nigroviridis_ENSTNIP00000010349 -------------------------------------------------MTRRSCLVPA- ---------------------------------V---GIVSGLLLAVGI--GLV------ -VS-QVFRTLMHNRLKKEIVL----VE-GS----RVFEYW--N---PAPSVYME-FFFNV TNLDQVLAG----GKPEVTQVGPYTY--R----EY--------------RYKENVSMVQ- N--GTRVSAHTIKS--FVFLPERSVGDPS--GDNITTVNIPV------------------ W------AV--------MNKVSGN------LFKSSMV--SLWMNSL---KS-GLFTTRTV NELLW-GYQ---------DPLLTKVS---------A-TNP-----DV----EKVFGLMYK KNGSS--NGEFVY----------HTGQQ-DYLD--YGR-VETWKGQ-------RQ----- -----LT--FW------------K------S--NQS--NSING--SDGSAFHPL----L- TKDERIYIFTPDLCRSIYM-EFEK--DVTV-KGIPAYRFTPP-RSVF-ASKEENP-ANEG F--------------------------------CLS-------------PKEC--LGTGL LKVSPC--RK---GA-PVVASFPHFHLADEKYVNAIKGMS-PQLEHHQ-TFLDLNPTT-- -GVI-VRAN-KRAQVNILLRTVCVMM---KT-RVL--N-ETVFPVMFLNE---SVVIDDA SAARVQK-LLNIANVVSNFPL--IIIGLGAIMLAIFIVLLI-----------------RA HRQKN--GV-KNIVFTKALYS--------------------------------------- ------ASTEEDT-YSPVNDKEKEDPQNGTYIGLADKN--------DPQA---------- --------------------- >T_guttata_ENSTGUP00000005161 ------------------------------------------------------------ ------------------------------------------------------------ --------------AFQNVRI----DP-SS----ISFQMW-KD---IPVPFYLMVYFFEV LNPKQVL-RG---EKPVLSQRGPYVY--R----EY--------------RFKTNITFYD- N--DT-VSYLEYRH--LFFQPDLSNGT-E--DEYIVVPNIMM------------------ M------GA--------AVMMENKP-----GFMKFLL--SGALASL---KQ-EAFMNRTV GELMW-GYD---------DPLVDAIN---------L-IFP-----GMLP-FKGKFGLFMD FNNSN--SGLFTV----------NTGMK-NISQ--VHM-VDSWNGL-------KM----- -----VN--YW------------R------S--NQC--NMING--TAGEMWPPF----L- SP-TFLDFYSPDACRSLRL-VYEQ--SGEF-KGVPTYRFVAP-KTLF-ANGTDYP-PNEG F--------------------------------C-----------------PC--MQSGI LNVSTC--RL---NA-PMFISHPHFYNADPSLVNAVEGLR-PNKDQHG-LFLDLHPMT-- -GIP-MNCS-IKLQLNPVHKRVSGIT---QT-GKI--K-PVVLPLLWFAE---SGSIEGS VLKQFYTNLVLLPSVLEYLQY--TLLGLSAPLIISAAVLMA-----------------MR KGSVT--E----SSDTQSKATPS------------------------------------- -----SETTPLL----CD--SPSQDSPEA------------------------------- --------------------- >M_domestica_ENSMODP00000019581 ------------------------------------------------------------ ----------------------MASKIGGPKTTV---TLGVLGLIFSVL--GGV------ -MI-FVVPEMIRNQVLQNVRI----NP-SS----LSFEMW-KE---IPIPFYLSVHLFNV LNPDEVL-KG---EKPRVEERGPYVY--R----EY--------------RQKQNITFHD- N--DT-VSFLEYRT--FEFQPHMSHGS-E--TDYIVMPNVLV------------------ L------GS--------SVMMEHKP-----MSMKLLM--SLSFSMF---GQ-RAFLNRTV GEIMW-GYS---------DPLIDLLN---------K-YFP-----GLMP-FKDKFGLFAQ LNNSN--SGLFNV----------FTGVK-DFSK--IHL-VDRWNGK-------TK----- -----LN--FW------------N------S--DQC--NMING--TSGQMWAPF----M- TPDYNLQFYSPEACRSLSF-KYEK--SGEF-KGIPTFRFVAP-DTLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--LESGI QNMSAC--QL---NA-PMFLSQPHFFNADPVLVESVTGLH-PNKDEHS-LFLEVHPVT-- -GIP-MNCS-VKLQISLYMKSIPGIG---QT-GKI--N-PVVLPLVWFEE---RGAMEGQ TLSVFYTRLVLMPKLIQYLQY--VLNAVGCLFIIITLILVI-----------------RN QGTFF--L----FWSSDKKVSKN------------------------------------- -----SEAIQSY----SE--SLMTPAPNGTVLQEARL----------------------- --------------------- >A_carolinensis_ENSACAP00000014578 ------------------------------------------------------------ ----------------------MGGCCPPFRAAV---CLAVAGLACLAC--GIA------ -MI-VLVPRIVREQVVKNVRL----EP-NG----MAFELW-KD---IPVPFYFSVYLFEV LNPDDIL-RG---EKPVVNQRGPYVY--R----EY--------------RVKENITFHE- N--DT-LSFLEYRQ--FHFKADMSNGS-E--SDYIVVPNMLV------------------ M------GA--------AVMLEDLP-----FPVKLTI--SSTFALF---GQ-KAFMNLTV DQILW-GYD---------NPLVDFLN---------S-IKP-----GMIP-FKGKFGLLAD FNNSN--TGLFRV----------YTGVG-DISR--AHM-IDTWNGL-------KE----- -----VS--YW------------N------S--DQC--NMING--TSGELWPPF----R- TPSTPLEFYSPDACRSLTL-IYNQ--TREF-KNIPTYRYLAP-TTMF-ANGTDYP-PNEG F--------------------------------C-----------------PC--LQSGI QNVSSC--RL---NA-PVFLSHPHFFNADPALLEAVGGLH-PNKEEHE-LFLDLHPMT-- -GIP-MQCS-IKLQLNIFTKQVPGIL---QT-GRV--K-PVVLPLIWFAE---SGEVEGS ILHDFYISLVLIPAVMGYAQY--CLVALGGLLFIVAAFLGL-----------------KS KGKCF--L----FWSSNKGSESK------------------------------------- -----GATQS-------------------------------------------------- --------------------- >C_familiaris_ENSCAFP00000012634 ------------------------------------------------------------ ------------------------------------------------------------ -----------------NIVL----RN-GS----ETFDSW-KK---PPLPVYAQFYFFNV TNPEEILRG----EIPRLEEVGPYTY--R----EL--------------RDKADIQFGD- N--GTTISAVSNKA--YVFERNQSVGDPK--TDLIRTLNIPA------------------ V------TA--------MEWAHLH-------FFRELI--EALLKAY---QQ-TLFVTHTV DELLW-GYK---------DEILSLIN---------V-FKP-----EI----SPYFGLYYG KNGTN--DGDYVF----------LTGED-NYLN--FSK-IVEWNGK-------TS----- -----LD--WW------------T------T--DKC--NMING--TDGDSFHPL----I- DKDEILYVFPSEFCRSVYI-TFSD--FKSV-QGLPAFRYKVP-GEVL-ANTS----DNAG F--------------------------------CVP-------------KGNC--LGSGV LNISIC--KNGNSGA-PIIISFPHFYEADKKFVSAIDGMR-PNKDYHE-TFVDINPLT-- -GII-LRAA-KRFQINVYVKKLDDFI---ET-GNI--R-TMVFPVMYINE---SVLIDKD TASRLKS-VINTTLIITNIPY--IVMALGVFFGLIFTWLAC-----------------RG QGSMD--EG-TPDERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >B_taurus_ENSBTAP00000018959 ------------------------------------------------------------ ----------------------MGNLSRARRVTA---ALGFIGLLFAVL--GII------ -MI-VMVPSIIKQQVLKNVRI----DP-NS----LSFNMW-KE---IPVPFYLSVYFFNI VNPEGII-QG---QKPQVQEHGPYVY--R----EF--------------RHKSNITFNN- N--DT-VSFLEYRS--YQFQPDKSRGQ-E--SDYIVMPNILV------------------ L------SA--------SMMMENRP-----GLLKLMM--TLAFSTL---GQ-RAFMNRTV GEIMW-GYD---------DPLIHLIN---------Q-YFP-----NSLP-FKGKFGLFAE LNNSD--SGLFTV----------FTGVK-NFSR--IHL-VDKWNGV-------SK----- -----VN--YW------------H------S--DQC--NMING--TSGQMWAPF----M- TPESSLEFYSPEACRSMKL-VYKE--QGVF-GGIPTFRFVAP-STLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--RESGI QNVSTC--RF---NA-PLFLSHPHFYNADPVLAEAVSGLH-PNPKEHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLFVKSVKGIG---QT-GNI--Q-PVVLPLMWFEE---SGAMEGE TLETFYIQLVLMPKVLHYAQY--VLLALGCVLLLIPIIYQI-----------------RS QEKCY--L----FWISFKKGSKD------------------------------------- -----KEAVQAY----SE--FLMTSAPKGTVLQEARL----------------------- --------------------- >T_rubripes_ENSTRUP00000036580 -------------------------------------------------MTRRSCLVPA- ---------------------------------V---GILSALLLVVGI--GLV------ -VS-QVFRTLMHNRLKKEIVL----VE-GS----RVFPSW-KN---PPPPVYMEFFFFNI TNEEQILKG----GKPEVTQVGPYTY--R----EY--------------RYKDNVSMVQ- N--GTRVVAYNTKS--FVFLPEKSVGDPS--VDSITTVNIPA------------------ W------AV--------MNKVKGS------FFRSGMV--AMWMNSV---NS-GFFTTRTV HELLW-GYE---------DPLLARVS---------S-SSP-----DV----EKVFGLMYK KNGSN--DGEFVY----------HTGQQ-NYLD--YGR-VETWRGE-------SQ----- -----LS--FW------------N------S--NQS--NSING--SDGSAFHPL----L- TKDERIYIFTPDLCRSIYM-EFEK--DVEV-KGIAAYRFTPP-RSVL-ASKEENP-ANEG F--------------------------------CVS-------------PKEC--LGTGL LKVSPC--RK---GA-PVVASFPHFHLADEKYVDAIKGMS-PQREHHQ-TFLDLNPTT-- -GVI-VRAN-KRAQVNILLGRIPGFP---KT-RSL--N-DTVFPVMFLNE---SVVIDDA SAARVHK-LLTISTVVSNFPL--IIMGLGVVMLAIFIVLLI-----------------RA RQQKN--EV-KRIVFTKALYSRT------------------------------------- -----QASTEEDTSYSPVNDKEKEDPQNGTYIGLAGRSLVLLKSVSRTKC---------- --------------------- >G_aculeatus_ENSGACP00000021517 -------------------------------------------------MTRRSCAIYA- ---------------------------------A---GIACASLLVVGI--GLV------ -VA-QVFRTFMHNRLKKEIVL----VE-GS----RVFESW-KS---PPPPVYMEYFFFNM TNVDAFLAG----AKPQVTQVGPYTY--R----EY--------------RYKDNVSMLD- N--NTMVSAYNFKK--FVFLREKSVGDPA--VDNITTVNIPA------------------ W------AV--------MNKVKGS------FFRASMA--SMMMTSA---GS-GFFATHTV DEWLW-GYE---------DRLLARVA---------A-SSP-----DV----DKVFGLMYK KNGSH--SGEFVY----------HTGKQ-NSME--YGR-VETWKGE-------SK----- -----LT--FW------------T------S--NQS--NSING--SDGSAFHPF----L- DKNERIYIFTPDLCRSIHM-EFEK--EVEV-KGIPAYRFTPP-RSVF-ASKEENP-ANEG F--------------------------------CVS-------------PKEC--LGTGL LKVSPC--RK---GA-PVVASFPHFYLADKKYVAAIGGMS-PKREHHQ-TYLDLNPTT-- -GVI-VRAN-KRAQINMLIERLSGFP---KT-KVL--N-ETIFPIMFINE---SVVIDDA SAARVHK-LLLIVTVVSNFPL--FIVGLGGIMLLVFIVLLF-----------------RA RKQKN--EV-KRTVFTKPLYA--------------------------------------- ------TSNEEGTSYSPVSDKEKEDPQNGTYISLTPKG--------DPEA---------- --------------------- >R_norvegicus_ENSRNOP00000001301 ------------------------------------------------------------ ----------------------MGVSSRARWVAL---GLGVLGLLCAAL--GVI------ -MI-LMVPSLIKQQVLKNVRI----DP-SS----LSFGMW-KE---IPVPFYLSVYFFEV VNPSEVL-NG---QKPVVRERGPYVY--R----EF--------------RQKVNITFND- N--DT-VSYIENRS--LRFQPDRSQGS-E--SDYIVLPNILV------------------ L------GG--------AVMMEDKP-----TSLKLLM--TLGLVTM---GQ-RAFMNRTV GEILW-GYE---------DPFVNFLS---------K-YFP-----DMFP-IKGKFGLFVG MNDSS--SGVFTV----------FTGVQ-NFSK--IHL-VDKWNGL-------SE----- -----VN--YW------------H------S--EQC--NMING--TAGQMWAPF----M- TPESSLEFFSPEACRSMKL-TYQE--SRVF-EGIPTYRFTAP-DTLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--RESGI QNVSTC--RF---GA-PLFLSQPHFYNADPVLSEAVLGLN-PDPKEHS-LFLDIHPVT-- -GIP-MNCS-VKMQLSLYIKSVKGVG---QT-GKI--E-PVVLPLLWFEQ---SGMMGGK TLNTFYTQLVLMPQVLHYAQY--VLLGLGGLLLLVPIIYQL-----------------RS QEKCF--L----FWSGSKKGSQD------------------------------------- -----KEAMQAY----SE--SLMSPAAKGTVLQEAKL----------------------- --------------------- >P_pygmaeus_ENSPPYP00000005810 ------------------------------------------------------------ ------------------------------------------------------------ -------------QVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDV INPNEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKTNITFNN- N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------ L------GA--------AVMMEDKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV GEVMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAE LNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M- TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGE TLHTFYTQLVLMPNVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS QEKCY--L----FWSSSKKGSKD------------------------------------- -----KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- --------------------- >M_musculus_ENSMUSP00000083242 ------------------------------------------------------------ ----------------------MGGSSRARWVAL---GLGALGLLFAAL--GVV------ -MI-LMVPSLIKQQVLKNVRI----DP-SS----LSFGMW-KE---IPVPFYLSVYFFEV VNPNEVL-NG---QKPVVRERGPYVY--R----EF--------------RQKVNITFND- N--DT-VSFVENRS--LHFQPDKSHGS-E--SDYIVLPNILV------------------ L------GG--------SILMESKP-----VSLKLMM--TLALVTM---GQ-RAFMNRTV GEILW-GYD---------DPFVHFLN---------T-YLP-----DMLP-IKGKFGLFVG MNNSN--SGVFTV----------FTGVQ-NFSR--IHL-VDKWNGL-------SK----- -----ID--YW------------H------S--EQC--NMING--TSGQMWAPF----M- TPESSLEFFSPEACRSMKL-TYNE--SRVF-EGIPTYRFTAP-DTLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--RESGI QNVSTC--RF---GA-PLFLSHPHFYNADPVLSEAVLGLN-PNPKEHS-LFLDIHPVT-- -GIP-MNCS-VKMQLSLYIKSVKGIG---QT-GKI--E-PVVLPLLWFEQ---SGAMGGK PLSTFYTQLVLMPQVLHYAQY--VLLGLGGLLLLVPIICQL-----------------RS QEKCF--L----FWSGSKKGSQD------------------------------------- -----KEAIQAY----SE--SLMSPAAKGTVLQEAKL----------------------- --------------------- >D_rerio_ENSDARP00000076810 ------------------------------------------------------------ ------------------------------------------------------------ ----------------QEITL----TE-GS----KVFATW-KN---PPPPVYMEFFFFNV TNPEAFLKGE---AKARLSEMGPYTY--R----EY--------------RPKHNVSFVD- N--GTKVAAYTPKV--FVFVPEKSVGDPS--VDMVTTVNIPA------------------ V------AV--------MNRIKGAG-----FLVSSAM--SLYMKSI---GA-EMFMTHTV DELLW-GFK---------DPLLTKLR---------S-IKP-----ET----DEFFGLMLH KNGSD--DGEFVY----------HTGEH-NYLD--YGR-IFTWKGE-------KL----- -----MS--FW------------K------T--NQS--NMING--TDGSAFHPF----L- TKEERLDVFTADLCRSIHM-RFEK--EVEV-KGIPAYRFTPP-RAVL-ASGTNNP-ENEG F--------------------------------CLT-------------PKKC--LDDGV LDVSVC--RQ---GA-PVVVSFPHFHLGDEKYVQAVEGLS-PVHEQHQ-TFLDLNPTM-- -GVP-VRAM-KRAQINIHLERVTGFP---MT-RNL--E-STIFPIIFLNE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_carolinensis_ENSACAP00000012360 ---------------------------------------------------MRKLCLGTA -------------------------------------GVLAMTLLIASV--ALL------ -AA-RVLQKVVELQVKQQMVL----KN-GT----EVFEMW-EE---SPPPVYMQFYFFNL TNPLEVLQG----EKPLVQEIGPYTY--R----ET--------------RPRVAVHILD- N--DTEVSSLNPKT--YFLDREMSVGDPE--VDLIRTVNVPA------------------ V------VA--------MNLATST-------PLHLPA--EILLLLY---EE-ELFTIHTV HELLW-GYT---------DKLLSALH---------K-FRP-----TI----DADFGFFKK MNGSD--DGEYIM----------LSGKK-NYLD--FTR-IIKWRGK-------DT----- -----LN--WW------------T------S--PDS--NMING--TDGSTFHPL----I- GTDEKIYVFSSDLCRSLYL-TFDE--YVTV-EGISAYRFVPP-VRLF-ANVSTNP-DNAG F--------------------------------CVP-------------AGNC--LGAGL LNVTAC--KQ---GA-PIFLSPPHFYLSDEKYANAIDGMH-PNKENHE-IFLDINPFS-- -GVL-VRAA-KRMQVNVHIQKLPDFL---QT-GNI--R-TLFFPVLYINE---SVVLDRA SAVKLKA-VLFESSVVTNIPF--IIMVLGVIFGVVFVVLAC-----------------KP SQARE--EG-SVDERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >X_tropicalis_ENSXETP00000002583 ------------------------------------------------------------ ----------------------SAMAGVGNKKSI---VFGVLGVLLVGV--GTL------ -LV-FLVPVIMDEQVEKNVRI----DPSSG----FAYEMW-RD---LPVPFYMSIYIFEV VNHKEVL-LG---EKPQLQERGPYVY--R----EY--------------KKKQNITFNE- N--GT-VSFVEFRT--FHFDPEKSNGK-E--EDHVIVPNILV------------------ L------GS--------SVMLQDLG-----IAIKWII--SGAFSAF---NE-EAFINKTV KDILW-GYE---------DPFLDFLN---------T-FLP-----GKLP-FKGKFGFFSD FNNSN--TGVFTV----------NTGME-DISR--VQM-VDNWNGL-------KK----- -----VD--FW------------N------S--EQT--NMING--TAGQMWPPF----R- KPSEPLEFYSPDACRSMKL-VYEK--EEKF-RGIPTFRYTAP-NYLF-ANGSDYP-PNEG F--------------------------------C-----------------PC--VASGV QNVSAC--RF---NA-PLFLSFPHFYNADPGFLESVEGLH-PTEELHS-LFLDMHPLT-- -GIP-MNCS-IKMQLNMLTKSVSGIM---QT-GQI--K-PVILPVLWFAE---SGHLDGP VYNTYYNILILMPIVLEYLQY--VLIGIGLCFITVALVLPF-----------------VK QGKCF--L----FWNSNKNVDES------------------------------------- -----QEFKTQ---------KEKLTAPNGIVLLEARL----------------------- --------------------- >C_familiaris_ENSCAFP00000010357 ------------------------------------------------------------ ------------------------PRSHLPDALA---GPGHAGWLWAAL--AGAPTNPPH GPV-CFAPP------LQNVRI----DP-NS----LSFNMW-KE---IPVPFYLSVYFFDV VNPDAVL-LG---QKPQVRERGPYVY--R----EF--------------RHKSNITFND- N--DT-VSFLEYRS--FQFQPDKSHGL-E--SDYIVMPNILV------------------ L------AA--------AMMMEDKP-----MSLKLIM--TLAFSTL---GE-RAFMNRTI GEIMW-GYE---------DPLIHLIN---------K-YLP-----NMLP-FKGKFGLFAE LNNSD--SGIFTV----------FTGVK-DFSR--IHL-VDKWNGL-------SK----- -----VN--FW------------H------S--DQC--NMING--TSGQMWAPF----M- TPETSLEFYSPEACRSMKL-IYKE--SGTF-QGIPTYRFVAP-STLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---NA-PLFLSHPHFYNADPMLAEAVLGLH-PNQEEHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYIKAIKGIG---QT-GKI--Q-PVVLPLVWFEE---SGAMEGK PLKTFYTQLVLMPNVLHYAQY--VLLALGCILLLIPIIHQL-----------------RS QEKCY--L----FWSSSKKGSKD------------------------------------- -----KEAIQAY----SE--SLMTPAPKGTVLQEARL----------------------- --------------------- >C_intestinalis_ENSCINP00000025688 ------------------------------------------------------------ ------------------------CKSKSCHIAL---GLIAILLIAGGAVLFGM------ ----DIADKFINMEMNKQLVL----SL-DS----PAYPQW-MN---PKPPIYMEYWLFNI TNPEEVS-NG---GKPNVTEIGPFRY--R----LF--------------QPRIDVAFYT- N--DT-VAYKYNHT--LVFVSEGSYNHPS--KINITQVNIPL------------------ F------TI--------KELIKTLP-----SWGETII--SNLVTLL---KDSDVFVTHSA QELLF-GYP---------DPVLEMAS---------Q-FLK-----VFGVSLPGEFGAFYG FNNSD--DGIYLA----------NTGRS-DLSL--AND-LQRWNGM-------ES----- -----LN--YW------------S------T--KEA--NMLNG--TDGVFMPPK----V- TDDDRLYIYTTDVCRSMYL-VFEK--DTEV-RSIATKRFHLP-AEVF-ANVTTNP-DNAG F--------------------------------CVP-------------AGNC--LDAGV LSLAPC--KQ---GA-PVIISSPHFYLGAEKYINGVNGLH-PNKNEHE-TILDIEPMS-- -GAV-FSAM-KRLQLNVDMKNSTVFP---KM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >T_guttata_ENSTGUP00000016695 ------------------------------------------------------------ ------------------------------------------------------------ ----------------QEAVI----VN-GT----TAFKNW-LV---PGSSVYREFWIFHV LNPSEVMEEG---AHPKLEQRGPYTY--R---RK-----------------DQLICDTV- S--AE-IKFIFEIP--ASYFIKKNVLL-L--CNLWPVVVLLR------------------ S------AV--------PSVYPS-------TLMQSVI--NTWVKSS---KA-AILQNRTV KEILW-GYT---------DPFLDSIP---------F---P-----NV----KSFVGVFYP YNGTS--DGPYSV----------YTGAD-DITKRHMTF-ILSY----------RT----- -----LS--YW-------------------K--GHC--DMVNG--TDGASFPPF----V- KKDQVLRFFSADICR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >O_latipes_ENSORLP00000000458 -------------------------------------------------MTRRSCCIYV- ---------------------------------T---GIVSAHLLILGI--ALV------ -VA-QVFQTMIHERLKQ--VG----PR-AC----AGREAV-SP---SPQQGHSTFRWLSI NLTPRFLSWE---EEARLASSSSLPA--F----NY--------------KPRENVTFLE- N--GTKLYALNPKS--FVFVPEKSAGNPE--VDMVTTINIPF------------------ V------AV--------MDELNSYS-----FFLRSMV--SIYMSSL---GV-DVFMNRTV HEILW-GFK---------DPLLSKIH---------S-MKP-----DV----DEYFGLMWK KNGTH--EGEFVF----------HTGEQ-NYLD--YGK-IDTWNGL-------RE----- -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I- NRNELLYIFAADLCRSIHL-AYVE--DVEV-KGIQAFRFAPP-EDVL-MSPKDNP-ANAG F--------------------------------CVP-------------AGDC--LGTGV LKVSVC--RE---GA-PIVVSFPHFYQADPKYINAVEGMN-PNKDEHE-TYLDLQPTT-- -GVP-IRAC-KRAQLNVIVKRIPGFP---KT-RHI--N-ETIFPIMFVNE---TATIDDG SAAQMKT-LLLIVTLVSNFPV--FIVGMGIILLLVLVVLFC-----------------RN RQKKN--EV-KRIDFNEAFPS--------------------------------------- -----FAVS--------------------------------------------------- --------------------- >A_gambiae_AGAP004846-PB ------------------------------------------------------------ -------------MYGRSNRLCAKLSSAFLRKWW---FVIAFALSLLVL--GAL------ -VT-FGFTAFIRTIIDHQVAL----RV-GG----QSFGWW-SR---PPVEPIIRIFVYNV TNADEFLNNG---TKPILDELGPYVY--V----QT--------------WEKVNIKENP- N--GT-ISYNQKRV--YIFNEDLSGGL-E--DDVVIVPNIPM------------------ L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVEVSV GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLMYG KNSTS--KDTVTV----------WTGVD-DITQ--YGI-IDKYNGR-------SH----- -----QT--HW------------L------S--EQC--NRLNG--TDGSIFPPR----I- TKNSTLHVYEKDLCRLLPL-SFEK--EVTVRGGVKGYRFTPS-PDVF-ASVDKNP-NNMC Y--------------------------------CPA-------------GPPC--APHGL FNVSLC--QY---DS-PILLSFPHFYMADQTLRTAVEGISPPEKDKHQ-LFIDVQPDM-- -GTA-LRAR-ARIQINLAVSQVVDIK---QV-ANF--P-DIVFPILWFEE--GIDSLPDE ILDLMKVATNIPPRAKFILTI--ALFGLGGFLFVVAVICLV-----------------RK SHRQS--TL-HLEGSNYLATASV------------------------------------- -----DQAKKKAKMDNGMSSKSN------------------------------------- --------------------- >M_mulatta_ENSMMUP00000038414 ------------------------------------------------------------ ----------------------MGGPTKARWAAA---ALGVAGLLCAVL--GAV------ -MI-VMVPSLIKQQVLKVAQV----DP-SI----LRIAAW-QV---VPISFFFFFFFFFE TESCSVS-VG---WSAPTRRHSPYAR--E----EF--------------RHKTNITFNN- N--DT-VSFLEYRT--FQFEPSKSHGS-E--SDYIVMPNILV------------------ L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV GEIMW-GYQ---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAE LNNSD--SGLFTV----------FTGVQ-NISR--IHL-VDKWNGL-------SK----- -----VD--FW------------H------S--DQC--NMING--TAGQMWPPF----M- TPESSLEFYSPEACRSMKL-MYKE--PGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---SA-PLFLSHPHFLNADPVLAEAVTGLH-PNQEAHS-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYMKSIAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGE TLHTFYTQLVLMPKVMHYAQY--VLLALGCVLLLVPVICQI-----------------RS K-----------VGAGQSVARAD------------------------------------- -----SYSLACWGKGASD--RTLWPTAAWSPPPAAVLLLCWSGSGHRWGLRCRLASFACR VATTLPVLEGLGPSLGGGAGG >D_melanogaster_FBpp0072308 ------------------------------------------MQLDDILHINNCKADCSS LSTTPNPKTDLVNMNGPKHKFCTKLSSTYLRKWW---ITIVVAAALIIG--GIV------ -VA-CEFTVLIDAVVDRMVAL----RP-GA----KTFGWW-AK---PPVEPRISLYIYNV TNADDFLSNG---SKAIVDEVGPYVY--S----ET--------------WEKVNIVEND- N--GT-LSYNLRKI--YSFREDLSVGP-E--DDVVIVPNIPM------------------ L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVQVSV GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLLYG KNGTS--SDRVTV----------NTGVD-DIRR--YGI-IDNFNGR-------TH----- -----LP--HW------------T------T--DAC--NTLAG--TDGSIFPPH----I- DHDRILHVYDKDLCRLLPL-VFEK--EVMTSNEVPGYRFTPP-EWVF-ADVDSHP-DNMC F--------------------------------CPAG------------KPSC--SPNGL FNVSLC--QY---DS-PIMLSFPHFYLADESLRTQVEGISPPMKEKHQ-FFFDVQPKM-- -GTT-LRVR-ARIQINLAVSQVFDIK---QV-ANF--P-DIIFPILWFEE--GIDNLPDE VTDLMRFAEQVPPKIRVALIV--GLCALGVILLLLSTFCLI-----------------RN SHRQS--TL-HLEGSNYLATAQV------------------------------------- -----DMNKKQNKDNQPARY---------------------------------------- --------------------- >A_aegypti_AAEL000256-PA ------------------------------------------------------------ -------------MHGRGNRLCAKLSSAFLRKWW---FVIAFALGLLVL--GVL------ -VT-FGFTTLVRAVINHQVAL----RK-GG----QSFGWW-SK---PPVEPIIRIFVYNV TNADEFLNNG---TKPVLDELGPYVY--V----QT--------------WEKVNIVENP- N--GT-ISYNQKRV--YIFDEEQSEGT-E--DDVVIVPNIPM------------------ L------SA--------TSQSKHAA-----RFLRLAM--ASIMDIL---KI-KPFVEVSV GQLLW-GYE---------DPLLKLAK---------D-VVP-----KEQKLPYEEFGLMYG KNSTS--KDRVTI----------WSGVD-DITK--YGI-IDKYNGR-------SH----- -----QT--HW------------L------S--EQC--NRLNG--TDGSIFPPH----I- TKNTTLHVYEKDLCRLLPL-SFEK--EVTVRNGVQGYRFSPA-PDVF-ASVDINK-DNMC Y--------------------------------CPA-------------GPPC--APNGM FNVSLC--QY---DS-PILLSFPHFYLADQSLRNAVEGISPPEKEKHQ-LFIDVQPEM-- -GTA-LRAR-ARIQINLAVSQVVDIK---QV-ANF--P-DIVFPILWFEE--GIDSLPDP ILDLMKVATTVPPKAKFVLTI--ALFAIGGFLFVIAVFCLV-----------------RK SHRQS--TL-HLEGSNYLATASI------------------------------------- -----DQAKKKAKLENGSHTN--------------------------------------- --------------------- >E_caballus_ENSECAP00000021856 ------------------------------------------------------------ ------------------------------------------------------------ ----------------QNVRI----DP-SS----LSFDMW-KQ---IPVPFYLSVYFFHV LNPNEVL-QG---GKPQVQERGPYVY--R----EF--------------RHKSNITFKD- N--DT-VSFLDFST--FSLGPGGPLSP-P--PGVLSLPGTRC------------------ F------SA--------AMMMEDRP-----MSLKLMM--TLAFTTL---GE-RAFMNRTV GEIMW-GYE---------DPLMNLIN---------K-YFP-----NMFP-FKGKFGLFAE LNNSN--SGLFTV----------FTGVK-DFSR--IHL-VDKWNGL-------SK----- -----VS--FW------------H------S--DQC--NMING--TAGQMWAPF----M- SPESSLEFYSPEACRSMKL-VYKE--AALF-EGIPTYRFVAP-STLF-ANGSVYP-PNEG F--------------------------------C-----------------PC--RESGI QNVSTC--RF---SA-PLFLSHPHFYNADPVLAEAVAGLH-PNPEEHA-LFLDIHPVT-- -GIP-MNCS-VKLQLSLYMKAVRGIG---QT-GSI--Q-PVVLPLLWFGE---SGAMEGK TLQSFYSQLVLLPKVLHYAQY--VLLALGCVLLLVPIVYQI-----------------RS QEKCY--L----FWSGSKKGSKD------------------------------------- -----KEATQAY----SE--TLMTSAPKGTVLHEARL----------------------- --------------------- >D_melanogaster_FBpp0110185 ------------------------------------------------------------ ----------------------------MIHWSL---IVSALGVCVAVL--GGY------ -CGWILFPNMVHKKVEQSVVI----QD-GS----EQFKRF-VN---LPQPLNFKVYIFNV TNSDRIQQG----AIPIVEEIGPYVY--K----QF--------------RQKKVKHFSRD G--SK-ISYVQNVH--FDFDAVASAPYTQ--DDRIVALNMHM------------------ N------SV--------LQISENDP-----GLALLLVHLNANLKAVFNDPR-SMFVSTSV REYLFDGVRFCINPQGIAKAICNQIK------------ESGSKTIREKSDGSLAFSFFGH KNGSG--HEVYEV----------HTGKG-DPMR--VLE-IQKLDDS-------HN----- -----LQ--VW-----------LNASSEGET--SVC--NQING--TDASAYPPF----R- QRGDSMYIFSADICRSVQL-FYQT--DIQY-QGIPGYRYSIG-ENFI-NDIGPEH-DNEC F--------------------------------CVDK-----LANVIKRKNGC--LYAGA LDLTTC---L---DA-PVILTLPHMLGASNEYRKMIRGLK-PDAKKHQ-TFVDVQSLT-- -GTP-LQGG-KRVQFNMFLKSINRIG---IT-ENL--P-TVLMPAIWVEE---GIQLNGE MVAFFKKKLINTLKTLNIVHW--ATLCGGIGVAVACLIYYI-----------------YQ RGRVV--EP-PVK----------------------------------------------- ------------------------------------------------------------ --------------------- >D_rerio_ENSDARP00000089887 ------------------------------------------------------------ ------------------------------------------------------------ -----------------MWRS----IP-KT----ISPTPC-GD---IPVPFFMSVYFFHI VNPDEIL-KG---ERPMVIQRGPYVY--R----EN--------------RWKDNITFHE- N--HT-VSYKEYRQ--YFFEESMSVGD-E--SDVVTIPNMLV------------------ L------GA--------SVMMENMP-----FPVRLLL--STTFKTF---NE-GPFLTKPV GELMW-GYD---------SKLVDFLN---------K-YLP-----GMLP-SSGKFGLFAD FNNSN--TGLFTI----------FTGRD-DIRK--VHM-VDSWNGL-------KN----- -----VD--YW------------R------S--DQC--NMING--TAGQMWPPF----M- TKETTMPFYSPDACRSFLL-FYSLFCPLYF-SSLPHYFFLVT-YHLF-SHVFCVPQPPSP F--------------------------------F-----------------TT--TNSSL LVFSLT--IS---GS-PTFISQPHFYNADPQLLDTVSGLS-PSEDEHG-LFIDIHPET-- -GVP-VNVS-VRLQLNLFLKKVSGIS---ET-GNI--A-EVVMPMLWFEE---TKYIIGC ILHSFISVLFIYLFILDSFIV--LFIYLFYLCVCAYIIMFL-----------------FK QVKSK--TS-GSSSTDVDPSSTT------------------------------------- -----SEKAPLLQSPTS------------------------------------------- --------------------- >A_gambiae_AGAP010133-PA ------------------------------------------------------------ ----------------------MCSPCTDFQKKF---ISLGCSSFLILL--AIT------ -LG-VLWPSLSEQVLHNKLVI----KN-GS----SNYDNW-IR---TPIPMYLEVYFFNW TNPDEVKTKNG--TKPHFVEMGPYTF--S----EV--------------HERVNLVWNA- N--NT-VTYEQRRT--WHFVPELSKGTL---DDQVTNLNVIT------------------ L------NA--------AHFLRNTY-----PLLRPLI--NIFLKTD---GS-LLWKNKPV RELLFEGVK---------DPLLDLLK---------TINST-----SLNI-PFDRFGWFVG RNLSDTFDGTFTM----------RTGAD-GLES--MGF-LTQWNGS-------PN----- -----TG--MY-------------------R--GKC--GEVYG--TSGELWPAS----S- NVPANITLFPSDICRSITL-QGRE--QVSL-YNIQGTKYVGD-DRVF-DNGVKYP-EASC W--------------------------------CNSN------------PTQCPDLKPGV FNASAC--KY---GS-PTFVSFPHFYLADESYQTAVTGLR-PNQTEHE-FYMAIEPST-- -GIP-LDVR-AQLQINEHLQPIKGFS---FY-EHV--P-DVMVPMIWFRQ---RATLTQE LAEQAKL-ALALPSLGIYVAV--FFGSIGIIMTSVFLFCSI-----------------KK WSQSA--EV-VPYEELQN------------------------------------------ ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0079088 ------------------------------------------------------------ -----------------MPTQNSAMWGQKSNRKL---IIGIFGFCLGLF--GIL------ -CG-MFWVDLFDWIMHKEMAL----AP-DT----RVYENW-KS---PPIDLSLDIYLYNW TNPEDFGNLS---TKPILEQVGPYRF--I----ER--------------PDKVDIHWHPE N--AS-VTYRRRSL--FYFDAAGSNGSL---DDEITTLNAVA------------------ L------SA--------AATAKYWP-----PVKRSLV--DVGLKMY---GA-EMSVQKSI DELLFTGYN---------DAMIDVAMAM-------PIFGD-----EVKV-PFDKFGWFYT RNGSADLTGVFNV----------FTGAD-QLAK--LGQ-MHSWNYQ-------EN----- -----TG--FF-------------------D--SYC--GMTNG--SAGEFQPQH----L- KPGDSVGLFTPDMCRTIPL-DYVE--TVDI-EGLEGYKFSGG-PRSV-DNGTQYP-ENLC F--------------------------------CG---------------GQC--VPSGV MNISSC--RF---GS-PVFMSYPHFFNADPYYPDQVEGLS-PNQKDHE-FYMVVQPST-- -GIP-LEVA-ARFQVNMLVEPIQGIS---LY-TGI--P-RIFFPLVWFEQ---KVRITPD MADQLKV-LPIVMLSGHIFAG--ICLIVGITLLCWTPVQIL---------------LASC RNRRY--DL-RTKTKTNGQYKSR------------------------------------- -----SQFSSAEELKSKASTLVCEKSVKGSPDSSPLLEKGRKPTIIKSQTGESVATASTA ISDNKQD-------------- >A_gambiae_AGAP004845-PA MPEMVAFYSPETVIP-----------------TTSDTEPRKPL--------KRRTSALN- -------TIFYYLGLEQRSGEDAKE-NQWIRILT---FVVLFVTFITSA--IGF------ -FI-MWFTNMYNNSLLEKLIL----SE-NS----TAAEWW-EN---PPVYPLLKVHVFNY TNTEDFFAGKA--TKLQVEDLGPYVY--K----ET--------------ANKVDITHNG- D--GT-ISYREHRY--IQYLPEESKGK-P--FDQVVVPNVVF------------------ L------TG--------VSKKRSEG-----TWNQIAF--NMAASSS---GS-SAFIKKPV ESMLW-GYE---------DKLLSLAK---------S-M-F-----GSDI-VSSSFGMLMT RNGTS--AENFTI----------FSGES-SLED--LAV-IKHLDGK-------SR----- -----LD--LW------------H------T--DEC--DRVGG--TDGSQFPPH----LM DRKHPLQVFIKSLCRKFPL-VYDS--EVTALDGIPAWRYKIP-NNVF-SHPDEHM-PNHC F--------------------------------CHLE------------SGSC--PPSGL FNITGC--SM---GA-PIFASFPHFYTGDRKLIESIEGVN-PVQEKHE-TYADIHPRL-- -AFP-IDGA-SRFQINIQVQKAAMVS---GL-EKF--TEGQYLPVIWLEV--VPGVISDD LRAMIYHSTYSANAIQMSL-------RVGSLAFFVLSVVL-------------------- -----------LIAKCFYSTRST------------------------------------- -----S----------------------K-----------------------K------- --------------------- >A_gambiae_AGAP005716-PA ------------------------------------------------------------ ----------------------------MVQCTL---IWAGIGAMMAVS--GAL------ -LGWVVFPRAVHEKVIEATEL----RQ-GT----DQYKRW-EA---LPQPLDFKVYIFNV TNPYEVMQG----RRPKVVEVGPYVY--F----QY--------------RQKDNVRFSRD R--SK-VHFSQQQM--YVFDAESSYPLTE--NDELTVLNMHM------------------ N------SI--------LQIAEDET-----YDSLRLI--NVELNRIFGRPD-TMFLRTTP KQFLFDGVPFCVNVIGIAKAICKEIE------------KRNTKTIRTMPDGSLRFSFFSH KNMTD--DGMFTI----------NTGIK-DPSR--TQM-IELWNGR-------TT----- -----LD--VW------------NNRSSGLS--SSC--NKIHG--TDGSGYPPF----R- TGVERMTIFSTDICRTVDI-KLTG--SSSY-EGIPALRYEID-NNFL-HEIGPEY-GNDC Y--------------------------------CVNK-----IPKSIVKSNGC--LYKGA LDLSNC---F---DA-PVVLTLPHMLGVAEEYTALIDGMD-PEPERHQ-IFVDVEPYT-- -GTP-LNGG-KRVQFNMFLRRIDAIK---LT-DRL--Q-PTLFPVIWIDE---GIALNED MVKLIDDSLMKVLSLLDVVQW--VLIGVGLLLAVLMPTVYF-----------------VK RCRGE--GS-RTVSPAVTATTSA------------------------------------- -----ASLSTVAGVTGDRSK---------------------------------------- --------------------- >A_aegypti_AAEL000227-PA MTEIKSTIKEQNATQQHGTSDMVHSNSAHQNNSSATSNSKKHL--------KKQTSALD- -------NIAFHLGIKKADNDHIDDRNLFVTLLL---LGVLVILFIASV--TGF------ -FV-MWFTDIYDNSLLENLKL----SH-KS----TAAEWW-EK---PPVNPLLKVHIFNY TNMDDFFSGKA--DKLKVVDLGPYVY--H----ET--------------AEKVNVSYHG- N--GT-ITYKELRS--YQFLANQSSGM-Q--YDKVVVPNIPM------------------ I------TA--------ISQSADES-----LFKKMVL--NTALSGV---DA-KAFKVLPV DPFLW-GYE---------DDLLNLAK---------K-FSF-----DNEI-SFSKFGILMT RNGTS--AETFTI----------YSGEN-DLKQ--LAI-IKDLNGK-------SS----- -----LD--IW------------T------T--DEC--NRVDG--TDGSQFPPH----LM DKRQTLYVFIKSLCRKFPL-RYEK--EVTLFDGIPAWRYKAP-TDVF-AHPSINA-DNQC F--------------------------------CHLG------------SASC--PLSGL LNATLC--SY---GA-PIYASFPHFYTGDRKLLEMVEGLD-PQREKHE-TFADIHPRL-- -AFP-IDGA-SRFQINIQVKKTSYIS---GL-EPF--NDGQILPVIWLEV--VPGHISEE LRNMIYHSTFSANAIQFSFKY-------GSLLICVTTFALL------------------- ------------AMTCYFRTKNA------------------------------------- -----DDTNSEKPEDQPTVKLNSMNSEIRS------------------------------ --------------------- >A_gambiae_AGAP003373-PA ------------------------------------------------------------ ------------------------------------------------------------ -----------------ELKL----RP-GS----RSYDSW-VS---PPFPLAMDVYFFNW TNPEDITNHS---TKPILEELGPYRF--I----EH--------------PTKVDIEWHDA N--AT-VSYRKKSL--YYFDEEGSNGSL---DDVISSINIVA------------------ V------SA--------AKRSKYWG-----YLKQKGV--SLGLNVY---EQ-KINVVKTA GELLFDGYE---------DNMVLMGK---------HMFD------ADEV-PFDRVGWFYT RNNSADLIGHYNV----------HTGVE-DIGM--LGK-MGEWNYK-------PR----- -----TD--FF-------------------E--GTC--GMLNG--SAGEFYPPG----L- SKERPIELFTPDMCRSLPL-DFEE--EVTI-HGLKAYKYSGD-RRAI-DNGTLYP-ETAC F--------------------------------SA---------------GEI--VPSGV LNISSC--RF---GT-PVFVSFPHYYGADPFYLDQVEGLS-PSKDKHQ-FYMSMEPTT-- -SVP-LDVA-ARLQLNIMIEPYENIN---LF-SDV--K-RVFLPVLWFEQ---HVLMPSE LAGEIGQ-ALTIPSIVRLCGI--AMVVFGALMLLWIPLERT-----------------FF RRRRV--A---------------------------------------------------- ------------------------------------------------------------ --------------------- >D_rerio_ENSDARP00000071723 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VGVSSF--R----EY--------------RPMEEVKFMD- N--GTRVAAINPKT--YVFEPNMSRG-SQ--DDLVRTVNIPA------------------ V------IR--------AQENTLNT---YKFFPLILI--SDLMKAK---GV-GVFETFRV GDLLW-GYE---------DPLLKELH---------M-LVP-----------DDHFGLFYK KNGTE--YDSYVL----------LTGKP-DYQD--FAS-IDEWNGQ-------RS----- -----LN--WW------------S------S--EEC--NMING--TDGASFHPI----I- TKADRLYIFSSDLCSSGIC-RVSD--VTFF---VPQINLVPL-NFSFIKEDNKNP-DNAG F--------------------------------CVP-------------PGHC--LGSGL LNASVCCVFS---GA-PIIMSSPHFYQADQKFVDDIWGMK-PIKEEHQ-TFADINPLT-- -GIV-LQGA-KRVQVNVYLQQHSSFS---QT-GKI--Q-TLVFPVMYINE---SAFIDEE SAKKLHA-VVLNANVVINIPF--IVISVGILLGIIFIVLMC-----------------RQ Q----------------------------------------------------------- ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0077748 ------------------------------------------------------------ ---------------------MCCKCCGETQRKV---WVFGLGSVFLLL--GIL------ -IV-VFWPGIADNLVEDGLTL----KP-GT----DAYESW-LE---APIPIYLSFYMFNW TNPEDIRNPD---IKPNFVEMGPYTF--L----EK--------------HKKENYTFYD- N--AT-VAYYERRT--WFFDPERSNGTL---DDMVTAAHAIT------------------ A------TV--------ADEMRDQR-----KIVKKII--NFMLNHE---GG-KLYVTKPV GEWIFEGYQ---------DNITDFLN---------LFNTT-----KIDI-PYKRFGWLAD RNESLTYDGLFTI----------HTGTD-DISN--LGR-LTHWNGK-------SE----- -----TG--FY-------------------E--MPC--GIVNG--TTGDMFPPK----M- NVNDEITIFATDACRFMNL-RPRG--TYEN-HGLTATKWVGT-EETL-DSGENYP-NQAC F--------------------------------CDEA-----------RFDEC--PKTGV VECKAC--RD---KA-PIYSSFPHFYLADQSYVDAVSGMK-PEKEKHE-FFLAVEPIT-- -GVP-VQVH-GRIQINMMIEPDDDFD---IY-RGV--Q-KVLMPMFWFDQ---YAELSSE LASKAKL-AINLSSYGIIFGY--SMIAFASVFLITGITLTV-----------------TK KWVRR--TP-EDEDILTN------------------------------------------ ------------------------------------------------------------ --------------------- >O_cuniculus_ENSOCUP00000002939 ---------------------------------------------------MGRCGFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQAVQKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXX XXXXXXXXX----XXXXXXXXXXXXX--X----EL--------------RNKANIQFGD- N--GTTISAVSNKA--YVFERNQSVGDPK--IDLIRTLNIPV------------------ L------TV--------IELAQNP-------LLREIV--EAMLKAY---QQ-KLFVTHTV DELLW-GXX---------XXXXXXXX---------V-FRS-----DI----SPYFGLFYG XXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XA----- -----LD--WW------------A------T--DKC--NMING--TDGDSFHPL----I- TSDEVLYVFPSDLCRSVYI-TFSG--FESV-QGVPALRYKLP-AEIL-ANTS----ENAG F--------------------------------CLP-------------QGNC--LGSGV LNASIC--KD---GA-PIIMSFPHFYQADERFVSAIGGMH-PNKEDHE-TFVDINPLT-- -GII-LRAA-KRFQINVYVKKLDDFL---ET-GDI--R-TMVFPVMYLNE---SVLLDKE SASRLKS-VINTTMIITNIPY--IIMALGVLLGLVFTWLAC-----------------RG QGSMD--E---------------------------------------------------- ------------------------------------------------------------ --------------------- >C_intestinalis_ENSCINP00000011713 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------YMEYWLFNI TNPEEVS-NG---GKPDVTEIGPFRY--R----LF--------------QPRIDVAFYT- N--DT-VAYKYNHT--LVFVSEGSYNHPS--KINITQVNIPL------------------ F------TI--------KELIKTLP-----SWGKTII--SNLVTLL---KDSDVFVTHSA QELLF-GYP---------DPVLEMAS---------Q-FLK-----VFGVSLPGEFGAFYG FNNSD------------------------------------------------------- ------------------------------------------------------------ ----------DDVCRSMYL-VFEK--DTEV-RSIATKRFHLP-AEVF-ANVTTNP-DNAG F--------------------------------CVP-------------AGNC--LDAGV LSLAPC--KQ---GA-PVIISSPHFYLGAEKYINGVNGLH-PNKNEHE-TILDIEPMS-- -GAV-FSAM-KRLQLNVDMKNSTVFP---KM-ANL--P-KVILPTLWLNE---SVVLDRV TANQFKSEVLGLIKAVHAVPC--ILLAIGGFLFVLALALLA-----------------HR YHKEK--TQ-LNIQEDSIRSLLT------------------------------------- -----ENDSFTDGA---------------------------------------------- --------------------- >A_gambiae_AGAP002738-PA ------------------------------------------------------------ ------------------------------TGTF---MLMAAGFMFIIC--GAL------ ----IHILDPYLLIFKWKLIF----QE-GS----EIFNLW-RT---PPVDLYIKIYLFNV TNAEDFMAGRA--EKMQIEEVGPYVY--R----EL--------------MSHDNITFND- N--GT-VSTRPHHP--LIFQKGMSGNLRE--DDVFMMPNIAL------------------ L------SI--------AHVAAKQP-----YFIRWPI--NLLIRQT---KV-QPLERQTA REFMY-GYP---------TTLTTLGY---------T-FLP-----NWIS--FDKVGLIDR MYDFD--DDFETF----------YTGET-TASV--SGL-YDTYLGS-------PD----- -----LA--QW------------N------G--SHC--SNIRN-ASDGTKFKSF----I- EPDDQLLFFRKSMCRAQILIQNGT--DYEV-DGLKATKFVFE-ENAL-DNGEYDP-RNKC Y--------------------------------CR--------------KGNC--LPRGL IDVTSC--YY---GF-PIALSYPHFLDADPKVRSHVNGSR-PDPTAHR-SHFMINPIS-- -GLP-LELS-VKFQINMVLDDLSSMA---HC-EKF--S-KLVVPALWFEI--MMPGLPPT LLSRFLFYLKILPFGDQVVKH--SLLAFGGILLLVAITKVS-----------------LT LSSAY--SS-AYRISNELRESLW------------------------------------- ------------------------------------------------------------ --------------------- >A_aegypti_AAEL009423-PA ------------------------------------------------------------ ----------------------MCSCCSDMQKKM---VSFGCSAFLILF--AII------ -LG-TLWPSMSSKLLRDKLVI----KN-GS----VNYQNW-IR---TPIPMYLEVYLFNW TNPQDLDKFPT--VKPHFEEMGPYVF--H----EV--------------HDRINLEWNE- N--NT-VTFNQRRT--WNFDPELSRGSL---DDTVTNLNVIS------------------ L------NT--------AYFMRNAP-----TLSKMAV--EVLLSLD---GS-LIWENKPV RNLLFEGLD---------DPLLDLLK---------TLNNT------VKL-PFDKFGWFVD RNLSDTYDGTFTM----------KTGAD-SLEN--TGM-LTLWNGQ-------AQ----- -----TG--MY-------------------R--GKC--GEVRG--TTGELWPVS----H- SLKSNVTIFASDVCRSLTL-QYGE--QITI-HDVEGNKYVGD-ERVF-DNGTMFP-EAAC W--------------------------------CNSD--------------YCPDVKSGV FNASAC--KF---GS-PTFVSYPHFYLADPSYLDVVSGLS-PNKSKHQ-FYIAMEPHT-- -GIP-LDVR-ARLQINTHLQPIKGIG---MY-KDV--P-DIMVPMMWFTQ---RATLTPE LANQAKM-ALVLPALGIYIAI--FFGTTGTILVGIFAYICI-----------------RK WSSQ------VPYEELLR------------------------------------------ ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0072303 MSHTKDAEMSMPARQESDRTSAPSVTKSLTLNSTRSGVGTGNFGGYGMTNGAEKPSVLH- -------MIMEALGLRNQAQNREPTSKDIGTLIM---LGVMFLLFVISV--TGF------ -FV-MWFTEYYNNTILENLIL----AE-NS----DTANSW-LNPD-PKYDTLLKAHIFHY PNIDDYLAGRA--DKIKVVDVGPLTY--Q----EH--------------TVKDEVSFNK- N--FT-VSFRDRKS--YKFLPEKSSIG-E--HEVVRVPNVPL------------------ I------SA--------AGPVKRMK-----AFERLAV--STWIKQF---KE-PLFKNLTV SEYLW-GYE---------DSIIKLKS---------------------LGRGRRRFGLLMS RNGTS--VDSVQL----------NTGED-DITK--FSI-ITQFNGM-------PQ----- -----LD--YW------------E------G--DEC--NRIDG--SEPSMFSPH----LL QDRSTVNVFLQVLCRKVPL-HFEK--EVTIYNDIDVLRYRTP-MDVF-SHPSKNP-ANQC Y--------------------------------CQN-------------TELC--LPSGV INATKC--YG---DA-PIFPSFPHFFTGDPVLYQDFEGIE-PDAAVHQ-TYADIHPRF-- -GFP-ISGA-SRVQINIMLDKTPILR---NQGDRL--KNTTILPLMWIEI--TSGDFSEE VLHTLYLSTFGLNAIQQTLKYGTLLISVTSFSLIVAGVYYL-----------------NS RREQQ--LQ-ESKTSAELEALNG------------------------------------- -----GENVIVVHHIDMPVPLPVQDGGIHQGT---------------------------- --------------------- >A_gambiae_AGAP008179-PA ------------------------------------------------------------ -------------------MGGCCSNWSPTGKRL---CALGSTTALCVF--ALA------ -LG-LVWPALIWQIAKREFVL----EP-GT----EVYKNW-IE---PPIDTYLELYLWNW TNADAYLT-----EKPHLEQLGPYTF--R----EV--------------HERVNLKWND- N--DT-LTFQQRRI--WYHVPELSAGDYE--TDRVVTINPVL------------------ L------TV--------GYALRNEP------EFLFYVDGIIMLNGL---AT-TPFYDVLV REMIFEGYD---------DTLLTNLLAL-------LALLPEESRPPIDLPPYDRFGWFFG RNGSETYDGTFTI----------GTGKD-SVYN--TGV-MRLWNGA-------NA----- -----TD--YY-------------------R--GEC--GRIRG--TTGEVWPPWGRTLT- GTPPSVSVFAPDVCSSVTL-EYAE--EMER-YGIDGLRWIGT-DRVF-DNGLHYP-ETEC Q--------------------------------CTAE-----------DVADCPLLDNGA MDVSRC--KF---GA-PATVSYPHFYLANESYLKGISGMQ-PNEKEHR-FEMELEPYT-- -GVP-LGVR-AQLQVNLDVKQY-GMT---LL-KGI--P-EVMLPVLWFRQ---TASLTEE LADDIKV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_gambiae_AGAP005725-PA ------------------------------------------------------------ ------------------------------------------------------------ -----------------NLRL----WN-GT----ISFHYW-QR---PGVTRLTKVYIFNV TNPEGFL-AG---EKPKLVEVGPFVY--R----ED--------------MEKVNIKFHD- N--YT-VTYQHKKI--LQFVPELSVD--K--NLRITTPNIPL------------------ L---------------------YLS-----FFVAKTI--SVILTAT---KY-KPFISLTA DELVF-GYD---------DTLVSLAH---------R-FYP-----RNRR-PMEKMGLLNG RNGTL--TEYATM----------HTGHT-GMDK--FGY-FDKLNGL-------DH----- -----LP--HW------------D------G--EPC--RSIQA--SEGSFFPPR----DI TQKDTVYIYDKDLCRTLPL-VYRE--PVEK-DGISADLYTLA-EDAY-GPP--NE-NNSC F--------------------------------DH--------------SHYK--KYYGL QNISPC--QY---GA-PVYISNPHFYQSDPQLLDAVEGLE-PNAEQHK-TYFKIQPKL-- -GVP-LEGQ-VRVQLNLLVEKAPNVM---AT-KDF--R-DFVFPIMWLEE--GVSELTPP IRRWIYLATVFAPTALPILSY--GMILTGAFAMIYVFVRAYKNFVFTDDPTTELLEMGRR SLRRG--SH-LISNGQHRIL--H------------------------------------- -----RDSYILLKANGVVAAAGGESDIAGTGTEVVTSGNGSSNNNNHLLHNHNLLHSHH- -HHLYIQPKDQSLLAEEDSPA >G_aculeatus_ENSGACP00000018249 -------------------------------------------------MTRRSCCIYA- ---------------------------------T---GIVCAHLLIVGI--ALV------ -VA-QVFQTMIHSRLKKEITL----TE-NS--------QW-KDERYPPPPVYMEYYFSNV TNPELFLAG----GKAAVKQIGPYTY--R----EY--------------RPRVNITFLE- N--GTKLYALNPKT--FVFVPEKSAGNPE--VDLIRTVNIPF------------------ V------AI--------MNELNSYS-----FFLRTAV--SMYLKSL---GI-EVFMTRTV HEVLW-GFK---------DPVLTKVH---------S-LKP-----EV----DEYFGLMWK KNGTH--EGEFVF----------HTGEE-NYLD--YGK-IDTWNGL-------RK----- -----MS--WW------------S------S--NQS--NMING--TDGAVFHPL----I- NRNELLYIFAADLCRSIHL-GYVK--DVEV-KGIQAYRFAPP-NDVL-MNPKENP-TNAG F--------------------------------CVP-------------AGDC--LSTGV LKVSVC--RE---GK-RFFSPPPPPPPWGARMSAPVPPPP-PPPKKSP-FRPQPSPPC-- -LVSDIPAA-GRTRTDKVFSPQMHCW---NT-RRV--C--------TINR---------- ---QMRFNLIPAYKVLVAETN--LILVMGIILLLVLVVLFC-----------------RN RQKKN--EV-KRIDFTEAFHS--------------------------------------- -----FTTVKDDTAYTQVSDKPDEPSAN---QPTRNGSYIAMSPVEAQKC---------- --------------------- >A_aegypti_AAEL009432-PA ------------------------------------------------------------ ---------------------MMCGKCSNKAKRW---WSLGISVGICVI--AIA------ -FG-IAWPFIIRGEIEKQFAF----AP-GK----EVYENW-LN---PPIDSFLELYLWNW TNAEDYRS-----EKPHLEQLGPYTF--R----EK--------------MERIGLVWNDD E--DT-LTFSQRRT--WHFEPELSKGDLE--NDKVVTINPIL------------------ L------TL--------GFTMKDSP-------FLPFI--NALLNENPQFVD-NPFYNLRA KDVLFDGYE---------DLLLKNLLQV-------VEQNPVLGE-EFDLPPFDKFGWFYG RNESETYDGNFTI----------GRGTD-GFQN--LGI-LKLWNAA-------NH----- -----TG--FY-------------------R--DEC--GAVIG--TTGELWPPF----QE RQFTNVTVFSPDICSAVTL-QYDG--TFRL-HGVEGLKWKGN-DRVF-DNGHHYS-ETAC Q--------------------------------CTAP------------KEECPFLEYGA LDVSSC--KM---GA-PATVSFPHFYLANNSSLDAVEGLN-PNKEEHE-FMMALEPYT-- -GIP-LQVK-AQLQVNLLMEDY-KLT---LL-EGI--P-KIMLPVLWFRQ---TAQLNED LASDLKT-LLVLPYIGIYVAI--GVGILGVFCLALFLHYSL-----------------KV WK---------------------------------------------------------- ------------------------------------------------------------ --------------------- >G_gorilla_ENSGGOP00000006367 ------------------------------------------------------------ ----------------------MGCSAKARWAAG---ALGVAGLLCVVL--GAV------ -MI-MMVPSLIKQQVLKNVRI----DP-SS----LSFNMW-KE---IPIPFYLSVYFFDV MNPSEIL-KG---EKPQVRERGPYVY--R----EF--------------RHKSNITFNN- N--DT-VSFLEYRT--FQFQPSKSHGS-E--SDYIVMPNILV------------------ L------GA--------AVMMENKP-----MTLKLIM--TLAFTTL---GE-RAFMNRTV GEIMW-GYK---------DPLVNLIN---------K-YFP-----GMFP-FKDKFGLFAE XXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XX----- -----VD--FW------------H------S--DQC--NMING--TSGQMWPPF----M- TPESSLEFYSPEACRSMKL-MYKE--SGVF-EGIPTYRFVAP-KTLF-ANGSIYP-PNEG F--------------------------------C-----------------PC--LESGI QNVSTC--RF---XX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXVT-- -GIP-MNCS-VKLQLSLYMKSVAGIG---QT-GKI--E-PVVLPLLWFAE---SGAMEGE TLHTFYTQLXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXX-----------------XX XEKCY--L----FWSSSKKGSKD------------------------------------- -----KEAIQAY----SE--SLMTSAPKGSVLQEAKL----------------------- --------------------- >D_melanogaster_FBpp0079175 ML-------------------------------------------------SAQQEIDRG RRPANKEHQFTAPPPRLRRSSTKMTSRTRHCARL---GIVLLGICCIAS--GIY------ -LF-RNWIDMFTRMRGQEMAL----SP-NS----RSFEGW-KV---SPLPLDFDIYLFNW TNPDDFYVGSN--KKPHFEQLGPYRF--R----EK--------------PDKVDIEWHNH N--AS-VSFHKKSW--FYFDAAGSNGSL---WDKVTTVNSVA------------------ H------SA--------ARRAAVD------WFARTGV--NIANKLY---RQ-GVTITKTV DEMLFKGYE---------HPFISVGK----------LLRP------QDV-PYKRIGYHYP RNGSSEFDGDINM----------FTGAD-DIAK--MGQ-IHTWNNL-------TH----- -----TG--AF-------------------E--GTC--GQVHG--SMGEFFPPN----L- GTKDTVYMYMPKMCRAIPL-DYVE--TVTV-HGVTAYKFSGT-RHAV-DNGTLYP-DTRC Y--------------------------------CV--------------GGKC--MPSGV INIGPC--SF---NA-SVYMSFPHFYMADPSYLEAIEGLR-PEREKHE-FFMALEPNA-- -GVP-MDVG-GGFQANYYMEPIPGIT---LY-ENV--P-TVMIPMMWCEE---RVRVSEE IAADIAL-VPLIVLLGQIVTG--ILLAGGLICTCWYPTRQV------------------T HFCHS--DP-KAKASVLRPLNAF------------------------------------- -----GVNSSAATAPVAQLFRNNISSSGNERVGVRLLDYNRDSGIRLESGTMESSHRERL ISEDSPDVVVR---------- >D_melanogaster_FBpp0112038 MGLEKHYLRYGRTARDHLLDWATCGRGRRQQQQQQQQQTHAQPSQGSTATGRRSRPHVT- -------H------RGTPLSMLISNGVRISNNRL---AVIIIGIITLIL--GII------ ----LSSMPWLDYFILKNLRL----WN-DT----LSYHYW-QR---PGVIRLTKLYIYNV TNPDGFL-RG---EKPHLQEVGPFVY--R----ED--------------MQKVNVKFHEN N--YT-VSYQHKKI--LQFVPELSID--K--DTPITTPNIPL------------------ L------TL--------TSLSPKLG-----YLLSKTI--SVVVTAA---QF-KPFINVTA EQLAF-GYD---------DALVSLAH---------R-FYP-----KHMR-PMERMGLLLG RNGTL--TEVSSV----------KTGMD-SMDQ--FGY-IDQLNGL-------DH----- -----LP--HW------------S------E--PPC--TSIAG--SEGSFFPPR----EL TKSEVVHIYDKDLCRIIPL-KYVE--SLEK-DGIAADLFRLP-NNSY-GDSAHNP-ENKC Y--------------------------------DT--------------SEYE--PIQGL QNISPC--QY---GA-PVYISNPHFFESHPDLLNSVEGLK-PEREKHE-TYFKIQPKL-- -GVP-LEGK-VRIQLNLKVTRAKDVY---PV-RDF--R-DFVFPVMWLEE--GISELTPA IKRWIYLGTVIAPSAVPIGSY--LMILGGAFAIIFSFVRAYQNFMFAQDPTLEILEMGRR SLRRG--SS-FIAHQQHRLLVHH------------------------------------- -----RDSYSLLRH-GPMATCLGEGNREEDAQPII------------------------- ---------DVSLSGGISQES >A_aegypti_AAEL011222-PA --------------------------------MKQIMNVFGNRYNSVRTNDCDNGRFESF AANRRNLTRQFSIVDSFFHQRKEGERTRYPKYNF---FLMAVGLILICL--GVM------ ----SHMCNPYMLIFKWKLIF----EN-GG----EIFELW-RT---PPVDLYIKIFLFNV TNAEQYLEGTA--EKMVFDEVGPYVY--R----EL--------------LSHENITFYD- N--GT-LYTKPSHP--LVFQAHLSAGHKE--DDVFYLPNIAL------------------ L------SI--------AQVASKHN-----YLIRLPL--NLLIRQT---KT-VPLEKQTA RQFMF-GYE---------TTLTTLGN---------T-FLP-----NWIS--FNKVGLIDR MYDFD--NDFETF----------YTGVD-DESL--SGL-YESYLGS-------PK----- -----LA--QW------------E------G--DHC--SNIRN-ASDGTKFKSF----I- KDEEQLLFFRKSMCRAQRMVQTGS--NHEV-DGLQATKFVFE-ENAL-DNGQIDA-RNKC F--------------------------------CR--------------KGQC--LARGL IDVTDC--YY---GF-PIALSYPHFHDSDPSLLTKVIGLH-PNESLHS-SFFMINAVS-- -GLP-LKLS-VKFQINMAMGDISNMA---EC-ERF--A-NIVIPTLWFEI--TMLQLPRG LRNRFLFYLKYLRIFDRIMYF--LLLVGGSLLLLYAVIRVA-----------------LS VSLSL--TS-NNISRKNKKISKS------------------------------------- -----ERCAENRRHSLLKNNSSKLEKGSVQEREHFLT----------------------- --------------------- >C_intestinalis_ENSCINP00000010908 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------M-------SE----- -----LP--YW------------F------G--ETC--NMING--TDGTMTHPF----M- DKSKPTYFFIDEMCRSLHA-VYES--DFTV-EGIKGWKYSVP-PEIF-QSPLINE-DNSC F--------------------------------CADL-----------NHTVC--QHSGA ILVSSC--YY---GV-PLLVSLPHFLYEDGFYSEKLVGMN-PKKELHE-MVLVYEPTT-- -GMI-IKTE-SRIQLNIYMKPNKKVK---AL-NKI--QEEFGFPLLWLNE---NAVLQPS EASWFSKLLYKVDDVVILLQV--LICVLGAALMSLSLLCYL-----------------RC RKAYK--TT-KRAGSRKNLIIGQ------------------------------------- -----YNKDAELPTVTQNCVKF-------------------------------------- --------------------- >C_elegans_C03F11.3 ------------------------------------------------------------ ---------------------MASRSCICQVSAG---IIFLIGAALLVA--GLV------ -IVLNVFPNIVNNQINDSKVL----GLNADGTLNSFTDSW-VN---SKYISTMQYWVYDY TNTIGIMNRA---IYPDVREKGPYAF--D----EI--------------LTMDKLNFSEN G--EF-MEFRQIQT--FVFNPNKSCAGCDPYKDKVLIPDMGFQVGIDQIDTVIEGILKNP L------AATICHAIMKGKPNANQTCSNLGALIEGEL--GTLISLF---NV-SPFTTVTV DQLLFSGYK---------TPFVEKFLDEALGMLHFLFGTA-------PKPLDDPPIQLNP LNGTS--DIINTV----------LTGKT-DPLK--AGY-MTEFRSI-------SNNSLFN SIGNTLPPMWW---------PYANKTYCKDP--NSA--LVLTG--TNGDYFKNF----V- KKTDILPAFVSDVCRTIHF-VFDR--EVTV-KGFKGYRFVMP-PTQF-DYSLD---ENCG Y--------------------------------CIPL---KYGSYEYPAQSAC--LPSGL LDISQC---T---GG-PIIMSKPHFYQASKVVSKFVPRFK-PTYDNDE-TMLDIEPNT-- -GTV-LQAQ-KRLQINMLVNQFKHIR---SY-SVM--R-PGAYPLAWVNE---SFYMDQN TIDQLNSQLFTPVSTVNTICW--IAVGLGAGLIALSIVMVI-------------VSFCCF RDEHH--KT-S------------------------------------------------- ------------------------------------------------------------ --------------------- >A_aegypti_AAEL005979-PA ------------------------------------------------------------ ------------------------------------------------------------ ---------------MKNLRL----WN-GT----ISFHYW-QR---PGVTRLTKVYIFNV TNPEGFL-AG---EKPKLVEVGPFVY--R----ED--------------MEKVNIKFHD- N--YT-VTYQHKKI--LQFVPELSVD--K--NQRITTPNIPL------------------ L------TI--------STQSKHLG-----YFLAKTI--SLVLTAT---KY-KPFISLTA DELVF-GYD---------DTLVSLAH---------R-FYP-----RNRR-PMSKMGLLNG RNGTL--TEYATM----------YTGHT-GMEK--FGY-FDKLNGL-------DH----- -----LP--HW------------D------K--EPC--SSIEA--SEGSFFPPR----EV TNSDVVYIYDKDLCRSLPL-VYRH--PVEK-DGIPADLYTLA-EDSY-GPP--NG-NNSC Y--------------------------------EH--------------TDYK--PYRGL QNISPC--QY---GA-PVYISNPHFYQSDPQLLDAVEGLN-PQRDAHE-TFFKIQPKL-- -GVP-LEGQ-VRVQLNLLVEEAPNVM---AT-KNF--R-DFVFPIMWLEE--GVSELTPP IRRWIYLATVFAPMALPIVSY--GMILTGTFALIYVFVRAYKNFVFTSDPTTEFLEMGRR SLRRG--SS-MIINGQHRILM-Q------------------------------------- -----RDSYILLKA----------SEDANLYHHTSNNNTINTNNNLSSHHNHNLFHLPHL PHIPHHQPKDQSLLSDEDSTA >D_melanogaster_FBpp0110565 MKEFSKMFARRYSSVSRDVEASNQRQSAVTPGSGLSTDADPAVSCAAQVALQRIQRRKSL KANRS--MNPIDILSSFFNEPIQGKRNRVPTRLF---ILLVIGFLAIIT--STL------ ----IKVLEPYDLIFKWKLIM----TE-GG----EIFNLW-AQ---PPVDLYIKIYLFNI TNANAFLAGR---EQLRVEQVGPYVY--K----EI--------------MTHENVTFNS- N--NT-MSSTPSHP--LVWQEEMSGNCRE--DDEVVMLNIAM------------------ L------AI--------SHLTANQP-----FLVRMAL--KTLLLST---KS-EPIVRTTA KEFMF-GYP---------SALATLGN---------T-FLP-----NWIS--FEKVGLIDR MYDFS--TDFETF----------YTGVP-NPAL--SGL-YASYRGE-------TT----- -----LP--QW------------D------G--DHC--SNIEF-ASDGTKFKSF----I- QPNETVKFFRKSMCRPINLYRVGN--EKTY-GSLKGYNYVFE-DNAF-DNGATNE-ANKC F--------------------------------CR--------------KGDC--QPVGL IDVTDC--YY---GF-PISLSFPHFMNGDVGLQQNVTGIS-PDPDKHS-STFVIQPES-- -GLP-LSLS-VKVQINMHFKDLSNFP---VV-SVF--N-HLTVPMLWFEI--MMSKLPDS LDSRFNFYLNILPLVNPLGFW--SGILLGISLLGYAITKAT-----------------LH MSTFS--RR-AANITDVKYVRANLIQNIAGEAANHAYSPCDIKLLDDISVVRHPVNKQTV QDSGFSSKTTYALDMEPALLDTSESSDEGRDCDIVTISRNSTSTRFCADEKKCWLGDDIR VECFTESRAPQTILKREEQIH >D_melanogaster_FBpp0080584 ------------------------------------------------------------ ---------------------MCCSCCGVTQQKA---WVFGLGTFFAVS--GLL------ -AI-ICWPGFIDSGIMKALPL----TP-TS----KTFEKW-EE---LPIPVYVYMYLWNW TNAADVQANG---VKPIFAQLGPYVY--R----EE--------------RKKMDLEWHD- N--GT-VTFNPRRT--WFWEEELSGGKQ---TDLITAPHLPS------------------ L------AA--------SNQMRNSN-----VFLKFMF--NEALNAN---GG-HLFVTHTA AEWLFESFY---------DEFLHYAM---------TLNNP-----LVPKIESDHFAWFLN RNGSKDFEGPFTV----------HTGVG-DIKE--MGE-IKYWKGQ-------NH----- -----TG--WY-------------------D--GEC--GRLNG--STTDLFVPD----E- PKEKALTIFIPDTCRIINL-EFTG-QSETI-QGITGWKYEIT-PNTF-DNGQING-NAKC W--------------------------------CPLE----------RQPDNC--PATGA TDLGPC--AD---GV-PMYLSADHFMYADESYGSTISGYN-PNYDQNN-FYIIMERKM-- -GVP-LKVN-ANVMITLYIEPDSVID---IL-KGL--P-SFYAPLFTTAS---RAEIDEA LASELRL-ALNLPAIGRYTGV--GFLCLGCILIAVGILLTI-----------------KR KWYGQ--AE-LDKLALKDNEETPYEPEVPANVVERNF----------------------- ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0079173 ------------------------------------------------------------ --------------------------MIGKQRIW---QTSVLGLLLASF--SLF------ -SV-LYMEQIERWMLEWFMVL----RP-GT----MISSLW-QS---PAMDINVDLYIFNW TNSEKFSDPT---VKPRFEELGPYRF--T----ER--------------MQKVNVEWHDE N--ST-VSYRRRSR--FDFDPKLSVGRP---TDPIVAPNLLI------------------ V------GL--------YQKMVMWS-----PMLRSLM--LLALNIY---GK-EQAMIRPA SDWMFDGFD---------TPMIKMSKMVP------PSLVP-----EMKF-PYEKIGYAYP RNGSMEIYGHHNV----------YTGRD-EFQK--LGQ-IARWRYN-------NV----- -----TE--AS----------------------PRC---KLKG--SAGEFHPIP----L- VKGRPISYFLPDLCRELQV-DYSG--TTIF-EGIDAFVYRGS-ARNM-ANGTDNP-DNSC Y--------------------------------CQ---------------DNCQEVRSGL LNISSC--WY---GT-PVFASYPHFFKADPYYGEQVEGMK-PDKDRHE-MVIMLEPKT-- -GMV-LEIK-ARIMANLLVEPKTHL----IY-RTA--R-RTFFPLIWADY---NVRITDD LLVYVKL-MPILEFVGKICGI--LGVVLGLLMVFWYPHQMI-----------------WQ KSLMH--KI-EISSIETNSSLEP------------------------------------- -----VKNNDVEDSPLLKGLQYAAAKDGAGNGN--------------------------- --------------------- >D_melanogaster_FBpp0083430 ------------------------------------------------------------ ----------------------------MQVPRV---KLLMGSGAMFVF--AII------ -YGWVIFPKILKFMISKQVTL----KP-GS----DVRELW-SN---TPFPLHFYIYVFNV TNPDEVSEG----AKPRLQEVGPFVF--D----EW--------------KDKYDLEDDVV E--DT-VSFTMRNT--FIFNPKESLPLTG--EEEIILPHPIM------------------ L------PG--------GISVQREK-----AAMMELV--SKGLSIV-FPDA-KAFLKAKF MDLFFRGIN---------VDCSSEEFSAKALCT--VFYTGEIKQAKQVNQTHFLFSFMGQ ANHSD--SGRFTV----------CRGVK-NNKK--LGK-VVKFADE-------PE----- -----QD--IW------------P------D--GEC--NTFVG--TDSTVFAPG----L- KKEDGLWAFTPDLCRSLGA-YYQH--KSSY-HGMPSMRYTLD----L-GDIRADE-KLHC F--------------------------------CEDP----------EDLDTC--PPKGT MNLAAC---V---GG-PLMASMPHFYLGDPKLVADVDGLN-PNEKDHA-VYIDFELMS-- -GTP-FQAA-KRLQFNLDMEPVEGIE---PM-KNL--P-KLILPMFWVEE---GVQLNKT YTNLVKYTLFLGLKINSVLRW--SLITFSLVGLMFSAYLFY------------------H KSDSL--DI-NSILKDNNKVDDV------------------------------------- -----ASTKEPLPSANPKQSSTVHPVQLPNTLIPGTNPATNPATHHKMEHRERY------ --------------------- >C_elegans_Y76A2B.6 ------------------------------------------------------------ ---MPSSNNSSNGASSSSPIASKYSSGRMRRMSC---CQLVISAVLIGL--GSFLLFGSL ITHTVVVPKVVKSSIEENSRL----VN-GS----IMWEKW-AM---PEYKIRFNMYVYST KNPDEFMNG----AIPEVTGSGPYVF--D----KK--------------MENRVVSAE-- N--GT-VKYRRFFT--YNFNEQESCQTCI-LGNRIWVPNMIY------------------ Q------KF--------VEAASTEG----------MK--AAATTLL---SQ-TAFLEVEV EELLFEGYK---------DPFLDKVCEIPF-----MNFVC-----EAILDVPERIGLFFK ANGTG--SKVYEI----------DDGTR-NPDD--LGK-ILSYDES-------PI----- -----LDETWW------------S------T--DES--LKIKG--TDGSLFHPF----L- SKHEKLYVYVAELCRSIWL-EFKE--EVEY-RGLKAYRFVVP-PEVF---DVTHP-GNQG F--------------------------------CNPS--EKQFYESQNDSSNC--MPKGL LEISKC--QQ---SQPPITISLPNFLFAPSEVRGSVKGLN-ETDEIRDSIVVDIEPRV-- -GAV-LYAR-RVSQVNIEMWKGKNLTFPVNL-KKM--K-SALIPVLILHE---TSEIDDD SLEQIRSQLYETESIAYTSCD--VMMIIGAIMLLLGFLFLS------FSLGLCDPILGRR SKRAN--GL-SPEPLPPYVPKGE--------------------PNGYHHNHAYITGLFGK NFSNFEKNPIFKPSSVFFSNFQLFPLKIIFSVSVNFVNIALLVFLPIFITHTISPESPFF PTSSSL--------------- >D_melanogaster_FBpp0082805 ------------------------------------------------------------ -------------------MKLFTNKNQRNAKLL---RSAALGMTLLFF--GSL------ ----VIISDPLQSILDTQLSL----KP-GT----LLHRLW-LL---PPLDVYINVYMFNY TNVDEFTSGRA--SKLQLQEVGPYVY--K----EV--------------LSNHNVTYNES N--NT-ITYSPKRE--YVFAPERSVGDPK--IDRIRAPNIPL------------------ M------GV--------TTLASSLS-----MFAALGL--SAITRQL---NS-QPMLEMSV HDYMW-GYE---------DHLVELAS---------R-FVP-----NWID--FSSFGIMEK LFREGNESNVFNM--NLPEPKDKYGMRMTDAPR---GYTVDSINGE-------RG----- -----FK--GW------------QYNEETNG--TMC--NRIWG-SHDATLFPLD----M- DENDEFFLYRRTFCRRLPV-KFNR--TTTF-NGLDAFEFVME-PDSF-DSEVDNA-NSSC Y--------------------------------CK--------------NNRC--LKKGV GNVSPC--YY---NI-PLAITYPHFMHADPSLLEPFDGLQ-PNVSRFT-STFVVQPQL-- -GAP-MQGTHLRLQANQVVGKVNFNR---MM-TPF--E-NMILPLLWVDL--NIDVLCLT LRLLIHGIKWGFPLLQWSAAL--GMLLAGVYQLCSALLLCF-----------------WP TARQF--QK-VDQVERGTAVQVI---------------------------------GVGL GLATGLRKPSIHLDPEEQHHLLLGGGSFIPKMAKT------------------------- --------------------- >A_aegypti_AAEL002741-PA ------------------------------------------------------------ -----------------------------------IVRLGFLGMLFIVL--GCV------ ----IVVLNPTDLVVNNMLSM----NE-GS----YLHRLW-KK---PPLEVFISIYVFNV TNADAFMRGK---EKMKVEELGPYVY--Q----EY--------------LENHNSTFNA- N--GT-LSFTPIRR--QVFVPGRSVGDPR--HDLIIVPNIAY------------------ L------GV--------ASAAYRMS-----AWASIAV--AAALKPL---GM-SPFLNITV HDLLW-GYE---------DPLVQVAS---------T-LLP-----NIIH--FKKIGILDR VKLDS-IEEDYFAGDALQVAAEEEAEES-DEPI--RNYSIDLWNGS-------PG----- -----LA--HWGYVGKDHWDAERR------N--TPC--NTLQG-SYDGTVFPRN----I- SKTEVFKVYRKAFCRTLPI-AFER--EGMH-DGIKAYWFSIQ-ENAF-ESSLDDP-YTAC Y--------------------------------CR--------------NGHC--LPKGL GDLSPC--WY---NI-PVAVSLPHFYKGDPALSQAIEGLK-PQKELHD-AIIIMQPQL-- -GIP-MTAS-IRVQINL-LTNVKFIS---DL-KPL--D-KTVIPLIWAQM---VSCLEL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >C_elegans_Y49E10.20.1 ------------------------------------------------------------ ------------------------MLKKAPCLFG---SAIILGLLLAAA--GVL------ LLIGIPIDRIVNRQVIDQDFLGYTRDENGTEVPNAMTKSW-LK---PLYAMQLNIWMFNV TNVDGILKRH---EKPNLHEIGPFVF--D----EV--------------QEKVYHRFADN D--TR-VFYKNQKL--YHFNKNASCPTCH-LDMKVTIPNIVF------------------ Q------KL--------IDAADVTI---FGVRIKFAI--ESVLKMV---SE-APYITVKV SDALFDGYE---------DPIIDIVC-----------KNKILQFLCETNSLQRRVGFFYG QNGTT--DGIYEV----------DAGVP-SPSK--IGH-LYTWNNM-------TE----- -----MPEGTW------------D------T--KYA--RMING--TDGQLFSPM----L- KREDRLTIFVPQICRSIQM-EYTK--DVAV-NGVPSWRYAPP-LDLY-DPALP---QNRA F--------------------------------CNKNGMPRYFDNTTVQIENC--LPAGL IDLSRC--QA---GNPRVYLSNPHFYNSPMELWHSVTGLSVPTASNDL-TVVDIEPTA-- -GVP-TQAK-RIMQINVGMVK-GSLS---VT-ENT--T-NVVVPVLWMNE---TAYFDQG TRDQLIN-IFNAKHYSFIGGV--ISLSLGLIAWLAVFVVII--------------VYSRQ SDEEE--YG-RLVLEDEDEEPAQ------------------------------------- -----DENAVLA------------------------------------------------ --------------------- >A_aegypti_AAEL008370-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SA--------ANRARTWD-----YVRRKGV--SMGLSLY---DQ-DVFVAKTA GELLFDGYE---------DNMVLMGK---------QLFD------ASEV-PFDRVGWFYT RNNSADLIGHYNV----------HTGVD-DIMK--IGS-MAEWNYK-------PR----- -----TN--FF-------------------A--DQC--GMLNG--SAGEFYPPN----L- SKDVPIQLFTPDMCRSLPL-DFEG--EEEV-AGIKGYKYAGG-PRTV-DNGTMFP-ETAC F--------------------------------NA---------------GEI--VPSGV LNISAC--RF---GT-PVFMSFPHFYGADEFYLNQVEGLN-PDKSKHQ-FYMTMEPTT-- -GIP-LDVA-ARFQLNILIQSHPSIA---LY-EDV--P-RVFLPVLWFEQ---HVTMRPE FTGEIAQ-ALSIPTTARICGI--VMLVLGAIMVAWIPIERL-----------------MF RSRRR--DI-VTDAGTEKVLLQQ------------------------------------- -----NLAKTAILVPEKEKEAVADKLSTIVEAHPLIESKTVRLGAENGTTKT-------- --------------------- >A_aegypti_AAEL005374-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------MLIKNRKNLML----KP-GT----QMRGMF-EK---IPFPLDFKLYLFHV TNPDVVMKG----GKPRVREIGPYFF--E----EW--------------KEKYDTVDNEE D--DT-LTFTLKNT--WIFRPDLSKPLTG--DEMITIPHPLI------------------ L------GA--------LLMVQRDR-----EAMMPLV--SKGMDIIMNPLT-TGFLTTRV MDLLFDGIL---------IDCSSHEFSAKAL----CSGLESEGAVMPFNETHFKFSMFGL KNGTD--AGRWVV----------YRGVK-NIMD--LGR-VVSFNDE-------TE----- -----MD--IY------------D------G--DEC--NRYIG--TDSTIFPPF----L- TTKDKLWAWSPEICRSIGA-EYGG--KSKY-AGLPMSFFKLD----F-GDARNEP-EHHC F--------------------------------CRDP------------PDIC--PPKGT IDLAPC---L---GA-PIIGSKPHFYDSDPKLLAAVDGLT-PNEKDHD-VYIHFQLLS-- -GTP-VSAA-KRLMFSMEIEPIRDHA---VL-GNL--P-TVILPLFWAEE---GASLNKT WTNQLKYTLFLGLRFNTAVKW--LTIIIGTIGTIVGGFMHY-----------------KR TTKMV--NV-TPVQSVNGSSAKG-----------------------------KGAGMTVV GHQPDSKGGSVTAPVIPSAKDLLQN---SRNLPTVIEGLDKPQKVTVTEMQERY------ --------------------- >D_melanogaster_FBpp0080585 ------------------------------------------------------------ ---------------------MRCGCCSVRQQKI---WVFSMGGLILAI--GIF------ -LA-SAWPAVSRQWIRSLLPL----AP-NS----FIYNRW-VT---TPTPVYSTVFLFNW TNPGDLNTEG---VKPHFEQLGPYTF--S----DF--------------KVKEDLEWNQP Q-----VTYFGKRT--WHFLPEKSNGSL---DDVVIAPHFPT------------------ L------TA--------ALYSRRLR-----RILRKVM--NFTLNRE---GG-ATHMTHTA GQWLFDGYY---------DHLLDFVE---------QLHSP------LLPVYDNTFGWFYE RNNSKTAEGNFTL----------HTGRG-DLSQ--LGD-LLLWNGE-------NT----- -----TG--FY-------------------P--GEC--GKVNG--STGELWSPY----R- TWDQPTTIFLPDAARYLNL-FPKE--NLTI-DGIDVWRYEST-NLTI-DNGQLSP-DTEC F--------------------------------CLKN-------------REC--PRNGV LDYGPP--AF---NG-PFYMSHPHFFLTDQMYRENTTGLQ-PEESEHG-MYVIMEPTL-- -GIP-LSLR-GQLMISTKVVRDEAID---LF-KNV--AYDHYAPLFTMRL---HAELDEG LTKLLKL-ALNAAIIGMYTGI--GLVLLGMSIVVTGIFITK-----------------KH KWHSE-----QRPDKHLQCTQN-------------------------------------- ------------------------------------------------------------ --------------------- >A_gambiae_AGAP004643-PA ------------------------------------------------------------ ------------------------------------------------------------ -----------------KLSM----YE-GS----YLNRLW-KK---PPLEVFISIYVFNV TNPVAFMRGE---ERLRVQEIGPYVY--Q----EF--------------LEHRNSTFNQ- N--GT-LSFVPVRR--QVFVPERSVGDPK--QDRIMIPNIAL------------------ L------GV--------SSAAYRMS-----TFAAFAV--AAALKPL---GM-SPILNITT HDLLW-GYD---------DPLVRIAS---------T-LLP-----DIIH--FQKLGVLDR MFDDG--FDTVTINLPQSVHNQRHDAEI-DILP--EDISDDLIVGL-------EE----- ----------------EYYHDLIS------R--STT-EELIRS--YDGSVFPRN----I- SKTEVFKVYRKAFCRTLPI-AFER--EGEV-DGIKAYWFSIK-ENAF-ESSMDDP-YTSC Y--------------------------------CK--------------NNRC--LPKGL GDLSPC--WY---NI-PVAVSLPHFYKGDPSLSQAIDGLS-PNKEKHD-AVIIMQPQL-- -GIP-MKAN-IRVQISL-LTNVSFNS---EL-RPF--H-NTVIPLIWAEM---VRQ---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_aegypti_AAEL007748-PA M----------------------------------------------------------- ------------------------------------------------------------ ----SLDKKFWIKYTKIEKIL----SP-TS----RAFKLW-RR---PPVPVQWRITLFNW TNAEAFLANKV--SKPTFSEVGPFLY--S----EI--------------LEKVDARFNTK N--ST-ISYRRRSY--FAPDDLLDESLL---TRSVTNLNVVA------------------ L------TA--------ANRGKTEG-----YGAERGI--SFALYNL---DQ-KVLVTQQA GELLFDGYP---------EPMIQEMLDV-------LGTTP-----HNGLDVEDRFGWFRA VNGSKKFHGFFNM----------NSGKE-DASR--YGL-IRQWNYR-------DR----- -----AV--RT-------------------Q--GQC--GLYEG--FTGELFPTK----I- RHDQTLRIFLMELCRAVSF-EFER--EEEV-HGVLGYRFVAN-ERTM-DDV--------- ---------------------------------CIED-------------REE--LPRGA INMTQC--KD---GA-PLFASFPHFYSADEYYRGAIEGMS-PDNEKHQ-TFVTIEPKT-- -GTV-LRSS-IKLQINALLQRYNGVA---LY-QDA--P-RSFVPLLWYSK---SFDLPLE EAVKLRS-LLDVSQLGYLGGF--AVAAFGLLVAILAMGLRC-----------------AI RSTQK--KS-RGEGPRPVANGDT------------------------------------- -----RGEYEFVQNEQNKDKDRIKL----------------------------------- --------------------- >A_gambiae_AGAP002451-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RNHTE--AGRWVV----------YRGVK-NIRD--LGR-VVSYNEE-------TE----- -----MD--IW------------D------G--DEC--NQYIG--TDSTIFPPF----L- TAQDRLWAWSPEICRSLGA-HYVH--KSKY-AGLPMSYFELD----F-GDLKNEP-HNHC F--------------------------------CRDA------------PDDC--PPKGT MDLSPC---L---GG-PIIGSKPHFYGADPKLVEAVDGLA-PNKAAHD-VYIHFELASIC WVSP-VSAA-KRLQFSMELGPIRDHE---LF-GQL--P-DVILPMFWAEE---GASLNKT WTNQLKYQLFLGLKFNATVKW--LTIIIGTVGAVGSAYMYF-----------------RK ETKTT--DV-APVDVSTPDTNPS------------------------------------- -----------------SAKDGVVNVSLGRNLPPVID----------------------- --------------------- >G_gorilla_ENSGGOP00000008199 ---------------------------------------------------MGRCCFYTA -------------------------------------GTLSLLLLVTSV--TLL------ -VA-RVFQKAVDQSIEKXXXX----XX-XX----XXXXXX-XX---XXXXXXXXXXXXXX XXXXXXXXX----XXXXXXXXXXXXX--X----EL--------------RNKANIQFGD- N--GTTISAVSNKA--YVFERDQSVGDPK--IDLIRTLNIPV------------------ L------TV--------IEWSQVH-------FLREII--EAMLKAY---QQ-KLFVTHTV DELLW-GYK---------DEILSLIH---------V-FRP-----DI----SPYFGLFYE XXXXX--XXXXXX----------XXXXX-XXXX--XXX-XXXXXXX-------XS----- -----LD--WW------------I------T--DKC--NMING--TDGDSFHPL----I- TKDEVLYVFPSDFCRSVYI-TFSD--YESV-QGLPAFRYKVP-AEIL-ANTS----DNAG F--------------------------------CIP-------------EGNC--LGSGV LNVSIC--KN---XX-XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXXXXX-- -XXX-XXXX-XXXXXXXXXXXXXXXX---ET-GDI--R-TMVFPVMYFNE---SVHIDKE TASRLKS-MINTTLIITNIPY--IIMALGVFFGLVFTWLAC-----------------KG QGSMD--EG-TADERAPLIRT--------------------------------------- ------------------------------------------------------------ --------------------- >A_gambiae_AGAP010132-PA ------------------------------------------------------------ -------------------MCCCSKRYSNNAKKL---WAFGGVVAIFAA--AAF------ -FG-FGLPAIIDAVALTEFRV----KE-GA----RVYENF-FD---GEVPIFFDIYLFHW TNPEQIRDPN---VRPNFVQMGPYVF--S----ER--------------HERGMVSFND- N--DT-ITFNQKRI--WHYMPELSNGDYF--NDRVTTLNPVL------------------ A------TV--------GKTLEGDP-------LLPLLDGIIMANNL---AE-FLYKDVPV HEMLFDGHP---------DTLLTTLRDL-------LGALPPGTVPDISLPPWEGFGWFVE RNESLTYDGTFQM----------GTGTD-NHIN--TGV-MRQWNNA-------PQ----- -----VP--NY-------------------R--GVC--GQVRG--SAGEVWPPMGRNLG- DNIRPLNLFLPDLCSAITL-RHER--EFTV-HGLDGELWVGD-ARNF-DNGHTIP-ETEC Q--------------------------------CTSP------------IDQCPFYRPGV LDVSEC--KF---GA-PLVVSYPHFYLAHPSYRTAVTGME-PDRAKHE-FRFALHPFS-- -GIP-MAAN-GRIQYNMHLRDN-GMA---LF-RDV--P-DVIIPAFWIEQ---RMVLTKD IADDLKVQLL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_aegypti_AAEL009420-PA ------------------------------------------------------------ ---------------------MCCCNCSNTAKKV---WSFMGVVLIFGL--AAF------ -FG-FGFPAIVDSVARQEFVM----KP-GT----EVYENW-MN---SPVPMFMDIYFWDW TNPNEITNPA---VRPNFVQKGPYVF--K----EV--------------HERINASFNN- D--HT-ITFKQKRT--WQYVPEQSGGDFY--TDRVTTPHTIL------------------ M------TV--------GKLVAEMD----DPTLGDLV--NIILNNNDLVDG-ITYKDVLV RDILFDGAE---------DRLLAALQNL-------LALLPEVPE-GVELPPWDGFGYFID RNTSAEYDGIFRM----------NTGTD-SWTN--TGQ-MRTWNDE-------PT----- -----VP--HY-------------------R--GLC--GQVRG--STGSVNAPMTSAQT- RDPDDFVLFITDLCKAITL-KYDG--DFVL-NDLEGKVWVGD-DRVF-DNGHNFP-ETEC Q--------------------------------CTAP------------QDQCPVLKPGL LDVSGC--KF---GA-PLKVSFPHFYLADPSYLNAVTGLS-PMPQSHQ-FRYALHPFS-- -GVP-MSVN-GRLQYNVHVKDY-GLD---AT-RGV--P-DVMLPAFWVEQ---RVLLTQQ VIDDLMY-IDTLRSAGHITAF--VLVGVGVIAFGVALYFSI-----------------FV WKN--------------------------------------------------------- ------------------------------------------------------------ --------------------- >A_aegypti_AAEL000234-PA ------------------------------------------------------------ --------MNIMDAKLCEKKKKRHIKLCDLIAIS---SISCLAVIFFTV--GFF------ ----IQRNDLTKLILDDRLEM----RQ-FT----PHFKWWQNT---SDVLVTCKVYVFSV TNAERWMNNLD--EQLHFEEIGPIVY--R----ET--------------LDHHNVVFHPE N--ST-ISYNSRRQ--LHFMSELNESGIL--NKTIIIPNTAV------------------ L------AM--------AAKLQNSN-----SLVKWGY--RAILSSS---GD-KVFVNTTI FNYLW-NQT---------SPIIKSAR---------K-IVP-----FMVP--LENIGALSV MYNDY--NDRVNV----------RHGVQHGDNQ--FFM-INSYRNR-------PT----- -----VP--GY------------I------PENGDCFASIVNS--SEGALYQQN----L- DENSVIIYWRRTLCRAVPL-YFER--KVQR-GPILGYEYVLP-DSSY-DRLTNV--SEDC Y--------------------------------KG--------------QNDF--LENGM TDMSKC--YN---GF-PIAATSPHYYARNFTMANKISGMQ-PNREKHY-SYTIAEPTL-- -GIP-IDQR-ARTQSNLVIPSLTGFS---NDIQKF--S-NMILPMFWIEY--HQNELPLR IINLIRI-FNIVKDIQSYLPF--VFYALFILLLLIALNKAW-----------------KI DSKYI--QI-PSVMIQEKCLQNN------------------------------------- -----NNSDLIKQ----------------------------------------------- --------------------- >C_intestinalis_ENSCINP00000027668 ------------------------------------------------------------ -----------------------MGCCNKKCGLI---ATVIVGGILVIL--GGI------ -IN-VVFEDLFNQILLQESVI----AV-GT----LMYDNW-IE---VATPTYLSYYLYNM TNGDEFLAPRKPYVKPNLQEIGPYVF--R----EY--------------LSKDTVHFLDD DVPQQ-VYYRQKTM--IVFDRERSAGDL---SDLVTTVNPIG------------------ A------SMPAIVDFVFSQRNQTTP-----DAIYSAL--NTIYRTT---GT-ELIFTRSV NDILF-GFQ---------DNFFDLIA---------------------------------- ------------------------------------------------------------ --------------------------------------NLVN------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_gambiae_AGAP004847-PA ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTCRIFIFNV TNSERWLGGLD--DQLKMQEVVPIVY--R----EI--------------LEHDNVTFHEH N--ST-ISYVTRRR--LVFLPDRNVPGIL--NKTIIVPNISL------------------ L------GV--------AARMENDN-----FFMKRGF--NFIYSMS---GD-TVFSRMTI YDYLW-NTR---------PPFLDQAR---------K-FVP-----GMVP--SDNVGVLKT MYEDH--EDHVNV----------RHGKRYGDDQ--FFM-MNTYEYE-------PT----- -----VP--GF------------S------LAKGDCFASILNS--SEGATYPQN----L- DEQSVLIYWRKTLCRAVPL-YFER--RVQK-GPLTGYKYVLP-DNSY-DRLPDS--DADC Y--------------------------------KG--------------QFGL--LEDGM TDTSKC--SH---DV-PIVATSPHFYARNFSNAHKITGMI-PDRENQH-SYAIVDPSF-- -GIP-LDQC-ARTQTNLAIPELTGYS---ADIKRF--S-DMIIPMFWIEY----VRLSDS ALTEMNEK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------- >A_gambiae_AGAP012849-PA ------------------------------------------------------------ -------------------M---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KSLTYDGTFQM----------GTGTD-NHIN--TGV-MRQWNNA-------PQ----- -----VP--NY-------------------R--GVC--GQVRG--SAGEVWPPMGRNLG- DNIRPLNLFLPDLCSAITL-RHER--EFTV-HGLDGELWVGD-ARNF-DNGHTIP-ETEC Q--------------------------------CTSP------------IDQCPFYRPGV LDVSEC--KF---GA-PLVVSYPHFYLAHPSYRTAVTGME-PDRAKHE-FRFALHPFS-- -GIP-MAAN-GRIQYNMHLRDN-GMA---LF-RDV--P-DVIIPAFWIEQ---RMVLTKD IADDLKL-IEDLRWGFIYTAF--ALCGVAALLLGLSLYAAF-----------------FV WKD--------------------------------------------------------- ------------------------------------------------------------ --------------------- >C_elegans_F11C1.3 ------------------------------------------------------------ -----------------------------MRLFV---AIILAAVILLVFALGIF------ -LLIPFPIAIFQSIVDSQVYL----QQKSDGQLPTGTFYW-SK---IPAVQIWTFHLFNV TNPDEVLYYG---ATPNMLEIGPYTY--T----ET--------------EFKDFTQFRDN D--NE-IFYVNNKT--WVYDPTRSCEDCK-LSDSVQFANTAY------------------ M------ST--------VFMQIYQP---AGPIVGFGL--DVLTILL---GE-QPLRTVTA GGTLFDGYN---------DPLITLINSPLVKVLLSVLGNP------VQLPQVPAAGFFPH YSHTC--DGNYTI----------RTGKD-NTDY--VGQ-IKTWNGL-------TH----- -----LP--WW------------K------T--EDT--SDLRG-TCDGTIQKPG----I- QKTDTVVQFQSFLCRKYNL-HYHE--SKTV-NSIPTYGFKVE-DDSY-DAI-----KNPG YRYENFEKVNYFPNWPCGLNHTKQNNGNCALVDCNQYDNFCNACCDGSHVNGTYVMPPGM VP-QRCLPGQMVPTPFGAILSAPHFYGAPKVVTESMVGIH-PDPELHRPGTFYINPAT-- -GST-IGGE-FRMMLSIPVFQSLAWT---LM-SNA--P-NAIMPSFTLTI---GVVMKDY AVNYIYFNTVTIPNIVLGLGI--GFTAVSLIAVLLWGFCYF-----------------RS KRNAK--PF-VLQQHRTEPTWSVAE----------------------------------- ------------------------------------------------------------ --------------------- >D_melanogaster_FBpp0072310 ------------------------------------------------------------ ----------------------------MKSVQW---VKILLCLILACV--NVF------ LFVVSWGVDYRILVAREHIRF----RQ-EM----PTMDSW-IN---SPFG-KLKNYVFNV TNAEEFRSGRD--SRLKVKEIGPIVY--R----IV--------------GFNDILDRNET N-----VRYRKHRYRVVEFLPEESVAP-DVLNWTITSTNNVI------------------ L------GA--------ATKVKHTA-----PLAAFGF--DAALMME------DIFVTDSV YYFLW-EFT---------RPLLQTLS--------------------RISNIRPNVAVLYN ALKEK--EEVYTV----------NIGPKRGIEN--FFR-IETLNGEVIIREQLPH----- -----TR--QY------------D------S--NSCPFNVSGA--LDNSLFPPF----V- QPDTPLSIVAIESCRVLPL-TYQR--QERY-NGLDTFRYTLL------QSHQKPPG---- ---------------------------------CLDT-----------SYGVK--LPDGM FDVSQC--VI---NDAPSAFSMPHFYGSSYNWSQHYEGYT-PNAEDHE-PYILLEPVT-- -GIP-VTEK-YRFQSNIPIPDLRRFS---SRLSRF--S-NMMIPSFWYEF--EMGQLPGF VTSLMWINVNIVQHIQPYCMV--LFLVLALWSVLKAIRVACGDLGYVVLFRKLCGDLGTV TALET--KF-QATSASPDVAVK-------------------------------------- ------------------------------------------------------------ --------------------- >C_elegans_F07A5.3 ------------------------------------------------------------ ----------------------MGFRIRINKLDV---FLVVIAIVFIVF--GIV------ -TW-AAFSSIYSTLVIKNLQL----TENSDTSLGYSAFQY-TS---PQVDNIMKFYFFNV TNPDEVKYYS---AAPNLVEIGPFSV--M----ES--------------EQKKYLEFSDD K--SQ-MFYQNYKK--YILSKDYSCEDCD-WDRNIVFPNPPG------------------ L------GA--------VASMLDPQ-FQITKTGRTII--AVALTIL---GE-YPFVSHKV REVLFDGYE---------DALLSAAHSGFVTVLSGIFKGDGGSIVPIPIPAMPKFGYFQG YNNSR--DEEYWI----------ETGKK-DINQ--IGN-VQRWAGI-------TE----- -----LPGEWW------------T------T--PKA--RSIRG-SDSGSFTQMH----L- DESSTADMFFSFMCRSFTK-TFYQ--RETI-ESIPTIGYHIG-YDEW-DTTSD---NNVG FRYRNIEKRNYFPDWP--KCPPKGQCHQSGSIDCSKSINFCHACCDGSLYNGTYLLPPGM FPL-VCYPGRLQPTPFAVVYSPPHFLFSPDEVRTTVVGMA-PNKSLHEPMIYYHEPYS-- -GTT-LKVV-NRLQVNMPVIRSHDVP---SS-QNM--P-NVMIPLFWQDT---SPKYHQF IFNEVWLGFVLVPRLMRVLQF--VALGIGLLLVAIIVFLQL------------------R KGKPS--LI-RPLKTSFLETTSN------------------------------------- -----WLSSTSSSNSNESRGLRRM------------------------------------ --------------------- >C_elegans_R07B1.3 ------------------------------------------------------------ -------------------------MVSIKRYEI---ISFVIAAFFFLS--GLS------ -MW-IAFWPIFNSELRSNYKL----GANDDGSLHYAAFLY-AN---PPMKNVMKFNLFNV TNPDEVKYLG---AKPELIEVGGYAF--L----ES--------------EQKKYYEFSSD K--TK-MFYQNYKQ--YHYSEVDNDAGYN-YNDKIMFPNSIA------------------ E------GA--------VSTVFGPQ-SEFSPTAKILV--SIGLVML---GE-YPFISKTV KDVLMDGYE---------DPLLSVAHSGIFISLVNFYGYGSQ---LNYIPEMKTFAYLSG YNNSY--DENYWI----------NTGYN-DFNK--LGF-VESWAGL-------EQ----- -----LPASFW------------P------T--LEA--RQIKG-PDSGSLSKIH----L- TKTDELPFFLSFMCRSFKR-TYWQ--DGLV-DGIKTMAFAVP-YEEF-DTTLE---KNAG FRYKNQENVDYFPDW------------------CDKNTTTSLSQCQKT-ANGTFLLPPGI FPL-VCYPGHNAQPPFTVLVSPPHFLYSPPEVQHHLSGMN-PDPEKHKPMVFHQEKTS-- -GTA-LQVD-VRFQVNLPVVNNKGSI---MS-SQM--P-NVIIPLFYEDS---HALVKDF VMDTVWLGVIIVPRIIEYLKF--VLSFISICILTTLLVIRV-----------------RV KGTVS--VV--------------------------------------------------- ------------------------------------------------------------ --------------------- >A_gambiae_AGAP000016-PA ------------------------------------------------------------ ------------------------------------------------------------ -------------STSKEKSL----LP-GS----TLYKEW-RR---PTERPSWQFYVYNW SNAQAILEHQA--SSASFQEIGPFQY--E----EFNYHSPYAARPRTEVAEVVDVKYHQA N--GT-LSYRKRTF--FRPSGPHSTTTNGTESERIISVNFVA------------------ L------LA--------SHFGHSMD-----YSVQREL--SFMLHNF---RQ-TVTVTRTI GQLLFTGYR---------EPMMEPLR---------KLVCPTKR--RSVACQDERLAYFRT FNVTRRASEVYSL----------DVGLK-DRSK--YGT-VRSWGAA-------SV----- -----PA--AH-------------------GEFHPC--DGFAG--LTGEFFPSR----I- ERDQAIVIVLPELCRRLTL-EFDR--EQLV-AGIMGFRYAVRLVRPF-RSAQMSE-SNMQ S--------------------------------CPDT------------SIRL--GRYGI LNTNEC---N---GF-PL-------YESDQAHVSSNESTS-FSSDSDL-LYYLLEPTT-- -GTV-IESN-IDLTYHTFLRPNEHIA---LF-QSV--P-ELRIPLFRFAR---YYRLSEL KAAKLRQ-LLHLLDVGHQIAL--AGCVAGLTIILLAVVYAC-----------------WK AQRPS--KT-NNDQYRIIGMQLSD------------------------------------ ------------------------------------------------------------ ---------------------