>M_musculus_ENSMUSP00000027015 ------------------------------------------------------------ ---------MADKILRAKRKQFINSVSIGTING--LLDELLEKR-VLNQEEM--DKIKLA NITAMDKARDLCDHVSKK------------------------------GPQASQIFITYI CNEDCYLAGILELQ-------SAPSAETFVA------TEDSKGGHPSSSETKE------- ---------------------------------EQNKED--GTFPGLTGTLK-------- ------------------------------------------------------------ -----------------FCPLEKAQKL----WKENPSEIYPI-MNTT-TRTRLALIICNT EFQ--H----------LSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFA ACPE--HKTSDSTFLVFMSHGIQ-------EGICGTTYSN--------EVSDILKVDTIF QMMNTLKCPSLKDKPKVIIIQACRG-----EKQ-GVVL-L-------KDS--VRDSEE-D FLTDA-I-------------FEDDGIKKAHIEKDFIAFCSSTPD--NVSWRHPVRGSLFI ESLIKHMK-------EYAWS-CDLE-----------DIFRKVRFSFEQPEFR-------- ---LQMPTADRV----TLTKRFYLFPGH---------------- >R_norvegicus_ENSRNOP00000009993 ------------------------------------------------------------ ---------MADKILRAKRKQFINSVSVGTING--LLDELLEKR-VLNQEEM--DTIKLA NITVMEKARDLCDHVTKK------------------------------GPRASQMFITYI CNEDCYLAEILELQ-------SGPSAETVFV------TEDSKGGHPFSSETKE------- ---------------------------------KLNKEG--GAFPGPSGSLK-------- ------------------------------------------------------------ -----------------FCPLEIAQKL----WKENHSEIYPI-MKTP-TRTRLALIICNT DFQ--H----------LSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFA ACPE--HKTSDSTFLVFMSHGLQ-------EGICGITYSN--------EVADILKVDTIF QMMNTLKCPSLKDKPKVIIIQACRG-----EKQ-GVVL-L-------KDS--VGNSEE-G FLTDA-I-------------FEDDGIKKAHIEKDFIAFCSSTPD--NVSWRHPVQGSLFI ESLIKHMK-------EYAWS-CDLE-----------DIFRKVRFSFEQPDSR-------- ---LQMPTTERV----TLTKRFYLFPGH---------------- >O_cuniculus_ENSOCUP00000000956 ------------------------------------------------------------ ---------MADRILKDRRKRFINSVGTGTING--LLDELLEKR-VLNQEEM--EKVRVE NATVMDKARALLDCVIRK------------------------------GPQACQICINHI CEDDCHLAGLLGLS-------SGPQSENHFN-----AQDSLEAFSSFSAPQTT------- ---------------------------------QDNQVV--FTFSGP--SLK-------- ------------------------------------------------------------ -----------------LCPLETAQRI----WKEKSEEIYPIKMQSS-GRTRLALIICNT EFD--S----------LPRRTGADVDIRDMKMLLIGLGYSVDVKENLNALDMATELKAFA DRPE--HWTSDSTFLVFMSHGTR-------DGICGKNYSE--------QYSDILNVNTIF EMLNTKNCQSLKDKPKVIIIQACRG-----ENQ-GIVW-L-------KDS--IGDSGNTS LLNPD-D-------------FEYDASRIAHIEKDFIAFCSSTPD--NVSWRHPKQGSLFI MRLIKTMQ-------EYAWS-CDVE-----------EIFRKVRFSFELPEGR-------- ---TQMPTTERV------MRRFYLFP-H---------------- >P_troglodytes_ENSPTRP00000059619 ------------------------------------------------------------ ---------MADKFLKEKRKLFIRSMGEGTING--LLDELLQTR-VLNQEEM--EKVKRE NATAMDKTRALIDSVIPK------------------------------GAQACQICITYI CEEDNYLAGTLGLS-------ADQTSGNYLN-----MQDSQGVLSSFPAPQAV------- ---------------------------------QDNPAM--PTSSGSEGNVK-------- ------------------------------------------------------------ -----------------LCSLEEAQRI----WKEKSAEIYPI-MDKS-SRTRLALIICNE EFD--T----------IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELKAFA HRPE--HKTSDSTFLVFMSHGIR-------EGICGKKYSE--------QVPDVLQLNAIF NMLNTKNCPSLKDKPKVIIIQACRG-----DSP-GVVW-F-------KDS--VGVSGNLS LPTTE-E-------------FEDDAIKKAHIEKDFIAFCSSTPD--NVSWRHPTMGSVFI GRLIEHMQ-------EYACS-CDVE-----------EIFRKVRFSFEQPDGR-------- ---AQMPTTERV----TLTRCFYLFPGH---------------- >B_taurus_ENSBTAP00000027821 ------------------------------------------------------------ ----------------EKRKLFVHSVSKGTING--LLDELLEKR-VLNQEEM--EKIRDE NDTAMDRARVLIDTVIRK------------------------------GPQACQICISHI CEEDSHLAGILGLT-------SGSQSENYLR------QKPQAVVPPFPAPQAM------- ---------------------------------LDNPVK--LASSGPGGNLK-------- ------------------------------------------------------------ -----------------LCPPETAQRI----RKEKSGEIYPI-MERS-NRTRLALIICNT EFE--N----------LTRRDGADVDTRNMKVLLEGLGYKVDVKENLTASEMILELKAFA AHSE--HRTSDSTFLVFMSHGIR-------AGICGKKYSE--------EVPDILKVDDIF HILNTGNCPALKDKPKVIIIQACRG-----EKQ-GMVW-V-------NDS--VAASGNCS LVAPE-D-------------FESDAIKKAHIEKDFIAFCSSTPD--NVSWRHPIFGSLFI IKLIETFQ-------EYAWS-CDLE-----------EIFRKVRFSFELPDGK-------- ---VQMPTAERV----TLTRCFYLFPGY---------------- >H_sapiens_ENSP00000260309 ------------------------------------------------------------ ---------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTR-VLNKEEM--EKVKRE NATVMDKTRALIDSVIPK------------------------------GAQACQICITYI CEEDSYLAGTLGLS-------ADQTSGNYLN-----MQDSQGVLSSFPAPQAV------- ---------------------------------QDNPAM--PTSSGSEGNVK-------- ------------------------------------------------------------ -----------------LCSLEEAQRI----WKQKSAEIYPI-MDKS-SRTRLALIICNE EFD--S----------IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA HRPE--HKTSDSTFLVFMSHGIR-------EGICGKKHSE--------QVPDILQLNAIF NMLNTKNCPSLKDKPKVIIIQACRG-----DSP-GVVW-F-------KDS--VGVSGNLS LPTTE-E-------------FEDDAIKKAHIEKDFIAFCSSTPD--NVSWRHPTMGSVFI GRLIEHMQ-------EYACS-CDVE-----------EIFRKVRFSFEQPDGR-------- ---AQMPTTERV----TLTRCFYLFPGH---------------- >E_caballus_ENSECAP00000021890 ------------------------------------------------------------ ----------TGNVLKEKRRLFIRSVGTGTVNS--LLDELLEKR-VLNQEEM--EKVRDE NATVMDKARALIDAVIRK------------------------------GPQACQIFIGHI CEDDPHLAETLRLS-------SGPQSGNFLK-----TQDSQAVVHSSPALQAM------- ---------------------------------PDDLAK--LALSGPKVSLK-------- ------------------------------------------------------------ -----------------LCSPEVVERI----WKEKSAEMYPI-MGKSMTRTRLALIICNT EFD--N----------LSRRAGAEVDIASMKVLLEGLGYSVEVKENLTALDMTTELKAFA ARPE--HRSSDSTFLVFMSHGIR-------EGICGKKFSE--------KVPDVLEVNTIF QIFNTRNCPNLRDKPKVIIIQACRG-----ENQ-GVVW-L-------KDS--TGTSGSSS SLAPD-D-------------FEDDAIKKAHVEKDFIAFCSSTPD--TVSWRSPTTGSVFI EKLIENLQ-------EYAWS-CDLE-----------EIFRKVRLSFELPDAR-------- ---AQMPTAERV----TLTRRFYLFPGY---------------- >P_pygmaeus_ENSPPYP00000004377 ------------------------------------------------------------ ---------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTR-VLNKEET--EKVKRE NATVMDKTRALLDSLIPK------------------------------GARACEICITYI CEEDSYLAETLGLS-------ADQTSGNYLN-----MQDSQGVLSSFPAPQAV------- ---------------------------------QDNPAM--PTSSGSKGNVK-------- ------------------------------------------------------------ -----------------LCSLKEAQKI----WKEKPAEIYPI-MDKS-SRTRLALIICNE EFD--S----------IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELKAFA HRPE--HKTSDSTFLVFMSHGIR-------EGICGKKHSE--------QVPDVLQLNEIF KMLNTKNCPSLKDKPKVIIIQACRG-----DSH-GVVW-L-------KDS--VGVSRNIS LPTTE-E-------------FEDDAIKKAHIEKDFIAFCSSTPD--NVSWRHPTMGSVFI MRLIQHMQ-------EYACS-CDVE-----------EIFRKVRFSFEQPDGR-------- ---AQMPTTERV----TLTRCFYLFPGH---------------- >M_domestica_ENSMODP00000034022 ------------------------------------------------------------ ---------LTDKVLMEKRRLFVESVDRGVMNG--LLDDLLEVQ-VLNLEEM--EIVREE SKTNRDKARVLIDAVISK------------------------------GPKASQCFTKSI CERDGHLAEKLGLS-------SELNSNQSHISLCREQAPRPINICILRND---------- ---------------------------------NIER-T--TMNPGYLDTLK-------- ------------------------------------------------------------ -----------------LCSYEDFQQK----RKEMEGQIYPV-MEKG-FRTRLALIICNK EFD--E----------LPRRNGAENDVTGMQNLLEGLGYRVHVKENLTALEMESALKQFA SYPE--HRTSDSTFLVLMSHGVP-------GGICGKDYTD--------KVPQILDVNKIF QIFNTSNCPTLKDKPKIIILQACRG-----END-GVVW-V-------NDS--SKSSQQRC SQNLP-I-------------FEDDAVRRAHVEKDFIAFCSSTPD--NISWRNIYKGSLFI IQLILYIK-------KFAWC-YHLY-----------EIFCKVQHSFETPAEK-------- ---LQMPTIERA----TLTKYFYLFPGN---------------- >M_domestica_ENSMODP00000034033 ------------------------------------------------------------ ---------LTDKVLKEKRRLFVESVDRGVING--LLDDLLELQ-VLNLEEM--EILKEE SRTIRDKARVLIDAIISK------------------------------GPKASQCFTKSI WERDGHLAEKLGLS-------S---GKRKYLLGKADHSIHGEKLKTKQRH---------- ---------------------------------TIGKWK--VIHDDAIDTLK-------- ------------------------------------------------------------ -----------------LCSYADFQRI----KKEKEGQIYPV-MEKG-FRTRLALIICNK EFD--E----------LPRRNGAENDVTGMQNLLEGLGYRVHVKENLTALEMESALKQFA SYPE--HRTSDSTFLVLMSHGVP-------GGICGKDYRE--------KDPQILDVNKIF QIFNTSNCPNLKDKPKILILQACRG-----END-GAVL-V-------NDS--SDSSEHRC IQNLP-I-------------FEDDAVRRAHVEKDFIAFCSSTPD--NVSWRNIYKGSLFI IQLILYIK-------KFAWC-YHLY-----------EIFCKVQHSFENREEK-------- ---LQMPTIERA----TLTKYFYLFPGN---------------- >O_anatinus_ENSOANP00000016591 ------------------------------------------------------------ ---------PPAQLLKDRWCLIIESLTHGMISG--LLDDLLQMQ-VINQEEM--DTVREE HHRPAEKTRALLNSVIPK------------------------------GDLASQIFIDSL CKKNPFVAAKLGLS-------AGGQGQSGNTQFVGQSQMIPAVATSCSVPQALQA----- ---------------------------------PKTLTE--SHPDGSGEILK-------- ------------------------------------------------------------ -----------------LCPSEEREKL----QKENEGEIYPV-LVKA-GRQRQALIICNI KFE--E----------LCERVGAELDIKGMKKLLEDLDYTVQVERNLSATEMESKLKMFA GRPE--HKFSDSTFLVFMSHGIL-------EGICGTKYKK--------QEPDVLSYSTIF RVFNNINCPGLKDKPKIIIVQACRG-----ENE-GMAW-V-------SDS--LGPSAT-S SQEPE-D-------------LENDAIHRTHVEKDLIAFCSSTPD--HVSWRDPKTGSLFI VQLIKCFQ-------NHAWN-CDLE-----------SLFLKVQRHFETPKQK-------- ---LQMPTRERA----TLTKRFFLFPGH---------------- >C_familiaris_ENSCAFP00000031565 ------------------------------MYSSRQQHGLSLEHILKNGEIARDGKTYVV PIVEGVFVFLTEDKHDKNPFKILETVGKELITG--VLHGLLEKD-ILKLEDA--EKKTFY DAKPEDKPWVILNSVRQK------------------------------RQEAGQALVHTF INTDKYSTSVEAFV---------------------------------------------- ---------------------------------ENMPGPTIPDSEESTDTLK-------- ------------------------------------------------------------ -----------------LCPPETFVKM----YKEKAEEIYPI-KERK-DRTRLALIICNI EFD--H----------LSTRDGAELDIAGMESLLEGLGYSVVVKRKLTAKGMESVLREFA ARPE--HKSSDSTFLVLMSHGIL-------NGICGTAHSV--------ENPDVLAYDTIF QIFNNRHCLNLKDKPKVIIIQACRG-----ENP-GELW-V-------SDS--PKASTDSW THQPL-M-------------LKSDAIHKVHVEKDFIAFCSSTPH--NVSWRHITKGSLFI AQLITCFQ-------KYSWC-CHLE-----------GVFRKVQQSFEKPDVK-------- ---AQMPTIERV----SMTRYFYLFPGN---------------- >P_pygmaeus_ENSPPYP00000004373 ------------------------------------------------------------ ---------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQN-VLNWKEE--EKKKYY DAKTEDKVRVMADSIQEK------------------------------QRMAGQMLLQTF FNIDQISPNKKAHP---------------------------------------------- ---------------------------------NMEAGP--PESGESTDALK-------- ------------------------------------------------------------ -----------------LCPHEEFLRL----CKERAEEIYPI-KERN-NRTRLALIICNT EFD--H----------LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA ARPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDVLLYDTIF QIFNNRNCLSLKDKPKVIIVQACRG-----ANR-GELW-V-------RDS--PASLEVAS SQSPE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDSTMGSIFI TQLITCFQ-------KYSWC-CHLE-----------EVFRKVQQSFETPRAK-------- ---AQMPTIERL----SMTRYFYLFPGN---------------- >B_taurus_ENSBTAP00000027820 ------------------------------------------------------------ ---------MAEDKHNKNPLKMLESLGKELISG--LLDDFVEKN-VLKLEEE--EKKKIY DAKLQDKARVLVDSIRQK------------------------------NQEAGQVFVQTF LNIDKNSTSIKAPE---------------------------------------------- ---------------------------------ETVAGP--DESVGSAATLK-------- ------------------------------------------------------------ -----------------LCPHEEFLKL----CKERAGEIYPI-KERK-DRTRLALIICNT EFD--H----------MPPRNGAALDILGMKQLLEGLGYTVEVEEKLTARDMESVLWKFA AREE--HKSSDSTFLVFMSHGIL-------DGICGTMHSE--------EEPDVLPYDTIF RTFNNRNCLSLKDKPKVIIVQACRG-----ANR-GELW-V-------SDS--PPALADSF SQSSE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDIKKGSLFI TRLITCFQ-------KYAWC-CHLE-----------EVFRKVQQSFEKPNVK-------- ---AQMPTVERL----SMTRYFYLFPGN---------------- >P_troglodytes_ENSPTRP00000041705 ------------------------------------------------------------ ---------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQN-VLNWKEE--EKKKYY DAKTEDKVRVMADSIQEK------------------------------QRMAGQMLLQTF FNIDQISPNKKAHP---------------------------------------------- ---------------------------------NMEAGP--PESGESTDALK-------- ------------------------------------------------------------ -----------------LCPHEEFLRL----CKERAEEIYPI-KERN-NRTRLALIICNT EFD--H----------LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA TRPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDVLLYDTIF QIFNNRNCLSLKDKPKVIIVQACRG-----ANH-GELW-V-------RDS--PASLEVAS SQSSE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDSTMGSIFI TQLITCFQ-------KYSWC-CHLE-----------EVFRKVQQSFETPRAK-------- ---AQMPTIERL----SMTRYFYLFPGN---------------- >H_sapiens_ENSP00000347741 ------------------------------------------------------------ ---------MAEGNHRKKPLKVLESLGKDFLTG--VLDNLVEQN-VLNWKEE--EKKKYY DAKTEDKVRVMADSMQEK------------------------------QRMAGQMLLQTF FNIDQISPNKKAHP---------------------------------------------- ---------------------------------NMEAGP--PESGESTDALK-------- ------------------------------------------------------------ -----------------LCPHEEFLRL----CKERAEEIYPI-KERN-NRTRLALIICNT EFD--H----------LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA TRPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDVLLYDTIF QIFNNRNCLSLKDKPKVIIVQACRG-----ANR-GELW-V-------RDS--PASLEVAS SQSSE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDSTMGSIFI TQLITCFQ-------KYSWC-CHLE-----------EVFRKVQQSFETPRAK-------- ---AQMPTIERL----SMTRYFYLFPGN---------------- >E_caballus_ENSECAP00000010831 ------------------------------------------------------------ ---------MAEDRQERNLLKTLESVGKELITG--LSVGLVEKD-VLKLKEE--ERKKFY EAKPGDKPWVLVDSVRDR------------------------------RHEAGQILWQAL FNIDRSVISRKALE---------------------------------------------- ---------------------------------EIAAGP--AESAEPTDTLK-------- ------------------------------------------------------------ -----------------LCPHEEYLRL----CKERAEEIYPI-KDKK-DRTRRALIICNT EFD--H----------LPFRTGADFDLSGMKRLLEDLGYSVDVKEQLTATDMESVLREFA AHQD--HRSSDSTFLVFMSHGIL-------DGICGTTHSD--------EKPDVLPYDTIF RLFNNRNCPSLKDKPKVIIVQACRG-----ANR-GELW-I-------RDC--LAALA--- ---PE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDITKGSLFI TQLITCFQ-------RHSWC-CHVE-----------EVFRKVQQSFEKPSIK-------- ---TQMPTTERQ----SMTRYFYLFPGN---------------- >P_pygmaeus_ENSPPYP00000004374 AVPIVEGVFIFLIEDSCKKKRRKNFEAVFKCILQSGLDNLVINHMLKNNVAGQTSIQTL- PNTDQKSTSVKKDNHKKKTIKMLEYLGKDVLHG--VFNHLAKHD-VVTLKEE--EKKKYY NAKIEDKALILVDSVR-K------------------------------NRVAHQIFIQTL LDMDQKITSVKPLL---------------------------------------------- ---------------------------------QIEAGP--PESAESTNTLK-------- ------------------------------------------------------------ -----------------LCPREEFLRL----CKKNHDEIYPI-KKRE-DRTRLALIICNT EFD--H----------LPARDGAQFDILGMKELLQGLDYTVVEENNLTASDMESVLRAFA ARPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDVLLYDTIF QIFNSHNCVSLKDKPKVIIVQACRG-----EKH-GELW-V-------RDS--PASLAVIS SQSSE-N-------------LEADSVRKIHKEKDFIAFCSSTPH--NVSWRDRTRGSIFI MELITCFQ-------KYSCC-CHLM-----------EIFRKVQKSFEVPQAK-------- ---AQMPTIERA----TLTRDFYLFPGN---------------- >M_domestica_ENSMODP00000034020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LIAS--TAQTGSSGKLK-------- ------------------------------------------------------------ -----------------VCSREEFLMQ----RRLRVEEIYPV-MEKG-SRTRLALIICNK KFE--N----------ISERHGAEIDTIGMKTLLEDLDYNVYVKENLTSLEMESALKEFA SHPD--HQLSDSTFVVLMSHGVR-------HGICGIKHKN--------EDPDVFLYETMY EILNTRNCPNLKDKPKIIIVQACRG-----DNY-GEVW-V-------NDS--SASCAD-S PKELQ-V-------------FDHDAVSRAHSEKDFIAFHSSTPN--NVSWRHPRNGSVFI TKLIHYFQ-------QYCWC-YHIE-----------EIFRKVQNAFETPEYK-------- ---FQMPTIERL----SMTRYFYLFPGN---------------- >M_mulatta_ENSMMUP00000012901 ------------------------------------------------------------ ----------TDKVLKEKRKLFIHSMGEASL----------------------------- ------------------------------------------------------------ ---------------------------------------------------AM------- ---------------------------------QDNPAM--PTSSGSKGNVK-------- ------------------------------------------------------------ -----------------LCSQEEAQRI----WKEKPAEIYPI-MVKS-GRTRLALIICNE EFD--T----------LPRRTGAEVDITGMTMLLQNLGYSVDVRKNLMASEMTTELEAFA HRPE--HKTSDSAFLVFMSHGIR-------EGICGKKYSE--------QVPDVLQLNVIF EMLNTRNCPSLKDKPKVIIIQACRG----------------------------------- -------------------------------------------D--NVSWRHPTKGSVFI IRLIEHIQ-------EYACS-CDVE-----------EIFRKVRLSFEQPSGR-------- ---VQMPTTERV----TLTRCFYLFPGH---------------- >M_mulatta_ENSMMUP00000012893 ------------------------------------------------------------ ------------------------------------------------------------ ----------MADSIQEK------------------------------QRMAGQMLLQTF FNIDQISPSKKAHL---------------------------------------------- ---------------------------------NMEARP--PESGESADALK-------- ------------------------------------------------------------ -----------------LCPHEEFLRL----CKERAEEIYPI-KERN-DRTRLALIICNT EFD--H----------LPPRNGADFDITGMKELLEGLDYSVDVEENLTAKDMESALRAFA ARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHDE--------KNPDVLLYDTVF QIFNNRNCLSLKDKPKVIIVQACRG-----ANR-GELW-V-------RDS--PASLEVAS SQSPE-N-------------LEEDAVYKTHVEKDFIAFCSSTPH--NVSWRDSTMGSVFI TQLITCFQ-------KYSWC-CHLE-----------EVFRKVQQSFETPRAK-------- ---AQMPTIERL----SMTRYFYLFPGN---------------- >H_sapiens_ENSP00000376849 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLV PNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHD-VLTLKEE--EKKKYY DTKIEDKALILVDSLR-K------------------------------NRVAHQMFTQTL LNMDQKITSVKPLL---------------------------------------------- ---------------------------------QIEAGP--PESAESTNILK-------- ------------------------------------------------------------ -----------------LCPREEFLRL----CKKNHDEIYPI-KKRE-DRRRLALIICNT KFD--H----------LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFA ARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHKK--------KKPDVLLYDTIF QIFNNRNCLSLKDKPKVIIVQACRG-----EKH-GELW-V-------RDS--PASLALIS SQSSE-N-------------LEADSVCKIHEEKDFIAFCSSTPH--NVSWRDRTRGSIFI TELITCFQ-------KYSCC-CHLM-----------EIFRKVQKSFEVPQAK-------- ---AQMPTIERA----TLTRDFYLFPGN---------------- >P_troglodytes_ENSPTRP00000007279 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNLVINHMLKNNVAGQTSIQTLV PNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHD-VLTLKEE--EKKKYY DAKIEDKALILVDSLR-K------------------------------NRVAHQMFTQTL LNMDQKITSVKPLL---------------------------------------------- ---------------------------------QIEAGP--PESAESTNILK-------- ------------------------------------------------------------ -----------------LCPREEFLRL----CKKNHDEIYPI-KKRE-DRRRLALIICNT KFD--H----------LPARNGAHFDILGMKRLLQGLGYTVIDEKNLTARDMESALRAFA ARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHKK--------KKPDVLLYDTIF QIFNNRNCLSLKDKPKVIIVQACRG-----EKL-GELW-V-------RDS--PASLAVIS SQSSE-N-------------LEADSVCKIHEEKDFIAFCSSTPH--NVSWRDCTRGSIFI TELITCFQ-------KYSCC-CHLM-----------EIFRKVQKSFEVPQAK-------- ---AQMPTIERA----TLTRDFYLFPGN---------------- >G_gallus_ENSGALP00000001569 ------------------------------------------------------------ --------------LLRVRADFVSRVRKAVVSN--LLDELLAHR-VLNQAEV--DEVQEG NPVTTDKARSLIDTVRLK------------------------------GPRASAIFIDSL RKHDCNLAEQLRLC-------AHAEPPGAPLAAPSTVGFSDP------------------ -----------------------------------------PVSSQDLQWIQ-------- ------------------------------------------------------------ -----------------QCPLSEYQRI----KEAEGDQIYDIYQPRE-RRTRRALLICNT KFK--H----------LRQRDGAEVDVKEMTKLLEGLGYNVECHEDKTSQEMTTVMKKFA DHKD--HLTSDSTFLVFMSHGMS-------TGICGTKSN---------GTTDILSFNTIY ENFNNKHCRALMGKPKVVIIQCCRG-----DNI-GSVQ-I-------RDSIDPEMPTSTS DGWRCVE-------------LQGSKTREAHLESDFATLYSSTPD--TVSWRSPTEGSVFI QRLVEQFR-------NHAFN-SDLQ-----------EMFRKVQRSFENFP---------- ---RQLPTQERT----TMLKKFYLFPGL---------------- >M_mulatta_ENSMMUP00000012894 ------------------------------------------------------------ -----------------------------MLHG--VFNHLAKHD-VLTLNEE--EKENYY NVKIEDKALILVDSVR-K------------------------------NRVAHQRFTQTL LNMDQRITSVKSLL---------------------------------------------- ---------------------------------QIEAGP--PESAESTNTLI-------- ------------------------------------------------------------ -----------------LCPHEEFLRR----CKENHDEIYPI-KKRE-DRKRLALIICNT KFD--H----------LPPRTGADFDILGMKGLLQGLGYNVVDKTKLTAREMESELRAFA RRPE--HKSSDSTFIVLMSHGIL-------EGICGTAHDE--------KNPDVLLYDTVF QIFNNRNCLNLKDKPKVIIVQACRG-----KGR-GEHW-V-------RDS--PASLAVIS SQSPE-N-------------LEEDSVCRVHVEKDFIAFCSSTPH--NMSWRDRTKGSIFI TELITCFQ-------KYSWC-YHLM-----------KIFQKVQKSFEIPMAK-------- ---AQMPTIERV----SLTRDFYLFPGN---------------- >R_norvegicus_ENSRNOP00000029448 ------------------------------------------------------------ --------FTAKRTHERDPIYKIKGLAKDMLDG--VFDDLMDKN-VLNGDEL--LKIGEG ASLILSKAENLVESFFEK------------------------------TEMAGKIFAGHI ANSDKQLSLLQADR-------NQITGPSFQI-----LVFNSLSESRGKVEDEEMEVNVGV AHASHLM--------------------------LTVPQG--IQSTEVQDSLK-------- ------------------------------------------------------------ -----------------LCSRDWFCTM----KTERAEEIYPV-MEKE-GRTRLALIICNK KFD--Y----------LFDRDDAETDILNMKELLQNLGYSVVIKENLTAQEMETELMKFA GRPE--HQSSDSTFLVFMSHGIL-------EGICGVKHRN--------KKPDVLHDDTIF TIFNNSNCPSLRNKPKILIMQACRG-----RHT-GTIW-V-------STS-KGIATADTD EECVLSH-------------RWNNSITKAHVETDFIAFKSSTPH--NISWKVGKSGSLFI SKLIDCFK-------KYCWC-YHLE-----------EIFRKVQYSFEVPGEL-------- ---TQMPTIERV----SMTRYFYLFPGN---------------- >C_familiaris_ENSCAFP00000021904 ------------------------------------------------------------ --------VLTGKRQSQDPVNAIKVVASTMLNS--FLEDLKEKN-VLNKQEL--QTMGQT VNVITKKTENLVGDLTEK------------------------------TQVVGKIFKDHF LNSGSLLSLSWSST-------SATKPSGSCR-----PSYLTQARSRKKEEVPKILVFVIF LYKMVFL--------------------------LQVLQE--IQASQ-VKVRK-------- ------------------------------------------------------------ -----------------LCPCDHSHEP----KITNVHEIYPV-MEKE-GRTRLALIICNS EFD--Y----------LSKRQGSEIDILGMQDLLENLGYSVVVKENLSALEMKTELKNFA ARQE--HKFSDSTFLVFMSHGTL-------DGICGTKHRN--------EEPDILHDDTIF QIFNNRNCRSLKDKPKVIIMQACRG-----RGD-GAVW-V-------TDV--GEASAWTC DQPLQCY-------------IFNDAIEKTHVEKDFIAFKSSTPH--NVSWRLNTDGSLFI SHLIHYFR-------EFSCC-HHLE-----------EIFRKVQNSFETPNTM-------- ---IQMPTIERV----SMTRYFYLFPGN---------------- >M_musculus_ENSMUSP00000027009 ------------------------------------------------------------ --------MAARRTHERDPIYKIKGLAKDMLDG--VFDDLVEKN-VLNGDEL--LKIGES ASFILNKAENLVENFLEK------------------------------TDMAGKIFAGHI ANSQEQLS-LQFSN-------DEDDGPQ-KI-----CTPSSPSESKRKVEDDEMEVNAGL AHESHLM--------------------------LTAPHG--LQSSEVQDTLK-------- ------------------------------------------------------------ -----------------LCPRDQFCKI----KTERAKEIYPV-MEKE-GRTRLALIICNK KFD--Y----------LFDRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFA GRPE--HQSSDSTFLVFMSHGIL-------EGICGVKHRN--------KKPDVLHDDTIF KIFNNSNCRSLRNKPKILIMQACRG-----RYN-GTIW-V-------STN-KGIATADTD EERVLSC-------------KWNNSITKAHVETDFIAFKSSTPH--NISWKVGKTGSLFI SKLIDCFK-------KYCWC-YHLE-----------EIFRKVQHSFEVPGEL-------- ---TQMPTIERV----SMTRYFYLFPGN---------------- >G_gorilla_ENSGGOP00000015374 ------------------------------------------------------------ ------------DNHKKKTVKMLEYLGKDVLHG--VFNYLAKHD-VLTLKEE--EKKKYY DAKIEDKALILVDSXR-K------------------------------KRVAHQMFTQTL LNMDQKITSVKPLL---------------------------------------------- ---------------------------------QIEAGP--PESAESTNILK-------- ------------------------------------------------------------ -----------------LCPREEFLRL----CKKNHDEIYPI-KKRE-DRRRLALIICNT KFD--H----------LPARNGAHFDIXGMKRLLQGLGYTVVDEKNLTARDMESXLRAFA XRPE--HKSSDSTFLVLMSHGIL-------EGICGTKHKK--------KKPDVLLYDTIF XIFNSRNCXSLKDKPKVIIVQACRG-----EKH-GELW-V-------RDS--PASLAVIS SQSSE-N-------------LEXDXVCKIHEEKDFIAFXSSTPH--XVSWRDRTRGSIFI TELITCFQ-------KYSCC-CHLM-----------EIFRKVQKSFEVPQAK-------- ---AQMPTIERA----TLTRDFYLFP------------------ >M_musculus_ENSMUSP00000027012 ------------------------------------------------------------ ---------MAENKHPDKPLKVLEQLGKEVLTE--YLEKLVQSN-VLKLKEE--DKQKFN NAERSDKRWVFVDAMKKK------------------------------HSKVGEMLLQTF FSVDPGSHHG-------------------------------------------------- ---------------------------------EANLEM--EEPEESLNTLK-------- ------------------------------------------------------------ -----------------LCSPEEFTRL----CREKTQEIYPI-KEAN-GRTRKALIICNT EFK--H----------LSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFA ALSE--HQTSDSTFLVLMSHGTL-------HGICGTMHSE--------KTPDVLQYDTIY QIFNNCHCPGLRDKPKVIIVQACRG-----GNS-GEMW-I-------RES--SKPQLCRG VDLPR-N-------------MEADAVKLSHVEKDFIAFYSTTPH--HLSYRDKTGGSYFI TRLISCFR-------KHACS-CHLF-----------DIFLKVQQSFEKASIH-------- ---SQMPTIDRA----TLTRYFYLFPGN---------------- >E_caballus_ENSECAP00000006810 ------------------------------------------------------------ --------LAGRGPEKEDPVNLMKSIARNMFEG--FLDDL-ENN-VLSRDDL--RKLGKR VNRIVNGTENLVEDLSEK------------------------------TEVAGKIFLKHL LKPKKQMNLKSLAD-------YEDDESE-DT-----ESPFSSTESACEGEDEETEENAGL SQASVPP--------------------------MTDPQE--TQVSQPKDKLK-------- ------------------------------------------------------------ -----------------PCSHDHFRKL----KTTKAEEMYPV-MEKK-GRTRLALIICNK KFD--Y----------LSDRNGSEVDLVGMQDLLGNLGYSVVVEENLTALEMETALRHFA ARQE--HRSSDSTFLVFMSHGDL-------DGICGTKHNE--------EEPDILHDDTIF QIFNNRNCRSLRDKPKIIIIQACRG-----RGD-GSVW-V-------TDT--GVASAYSS DQPFQGY-------------IWNDAVTKTHVEKDFIAFKSSTPH--NISWRTDKTGSIFI SKLIYNFR-------KYSCC-HHLE-----------EIFRKVQRSFEIPSVV-------- ---IQMPTIERV----SMTRYFYLFPGN---------------- >M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------LSAPLE--IQGAQPSGRLK-------- ------------------------------------------------------------ -----------------LCPHAHFREL----KTKRADEIYPV-MEKE-GRTRLALIICNK EFH--Y----------LLNRNGSELDLLGMQDLLENLGYSVVIEENLTAQEMETALRQFA ARPE--HQSSDSTFLVFMSHGIL-------NGICGTEHWD--------QEPDVLHDDTIF EIFNNRNCRSLRDKPKVIIMQACRG-----SGA-GIVWFT-------TDS--GKASAETH GQLLQSS-------------ICNDAVTKAHVEKDFIAFKSSTPH--NVSWRHEISGSVFI SQIIYYFK-------EYSWS-HHLE-----------EIFRKFERSFETPNVV-------- ---TQLPTIMLI----SIFIYFILF------------------- >P_pygmaeus_ENSPPYP00000004372 ------------------------------------------------------------ --------FTDEKPSNGVPVHMVKLLIRTFLDG--IFDDLMENN-VLNTDEI--HLIGTC LKFVVSNAENLVDDITQT------------------------------AQIAGKIFREHL WNSKKQL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SSDISSD-GER--GPNTPGLIICNK EFN--Y----------LHNRNGSELDLLGMQDLLENLGYSVVIKENLTAQEMETALRQFA ARPE--HQTSDSTFLVFMSHGIL-------NGICGTKHWD--------QEPDVLHDDTIF EIFNNRNCRSLKDKPKVIIMQACRG-----NGA-GIVWFT-------IDS--GKASADTH GRLLQGN-------------ICNDAVTKAHVEKDFIAFKSSTPH--NVSWRHEINGSVFI SQIIYYFK-------EYSWS-HHLE-----------EIFRKVQHSFENPSIL-------- ---TQLPTIERL----SMTRYFYLFPGN---------------- >X_tropicalis_ENSXETP00000017024 ------------------------------------------------------------ ----------LAAQLKKVRKLFIDGCNAAIINN--LLDDLLDKS-VLTDSEV--EYINEC NAITKDRCRRMIDNIKNK------------------------------GDYSSNILLQCL VENHKTLAKNMGLD-------VSEPAIAPQPI---------------------------- ---------------------------------QEQNKK--TNENTEISSVI-------- ------------------------------------------------------------ -----------------HCSDKDFKEI----HDTQGDKIYEM-RKRE-GRKRFALIICNE KFE--T----------LTERQGAKVDLDGMTKLLNELGYQVLQETNLAKEEMLKVLKEFA AREE--HVDSDSTFIVLMSHGDK-------PGVCGTDSKKIEHEKGQCQVTNLLQTDEIF SIFNNIHCPKLRDKPKVIIIQACRG-----EER-GQKL-V-------CDAVALPPEEQ-- --------------------LEDDALHRVQRETDFICFCSSTPD--TVSWRHPTMGSLFI TGLIKKMN-------ELAHC-QPLM-----------DIFLEVQSSFKGQ----------- ---RQMPTQERS----TLTKKFYLFPGH---------------- >P_troglodytes_ENSPTRP00000047678 ------------------------------------------------------------ --------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENN-VLNTDEI--HLIGKC LKFVVSNAENLVDDITET------------------------------AQIAGKIFREHL WNSKKQL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SSDISSD-GER--GANMPGLNICNK EFN--Y----------LHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFA AHPE--HQSSDSTFLVFMSHGIL-------NGICGTKHWD--------QEPDVLHDDTIF EIFNNRNCQSLKDKPKVVIMQACRG-----NGA-GIVWFT-------TDS--GKASADTH GRLLQGN-------------ICNDAVTKAHVEKDFIAFKSSTPH--NVSWRHETNGSVFI SQIIYYFK-------EYSWS-HHLE-----------EIFRKVQHSFETLNIL-------- ---TQLPTIERL----SMTRYFYLFPGN---------------- >H_sapiens_ENSP00000364878 ------------------------------------------------------------ --------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENN-VLNTDEI--HLIGKC LKFVVSNAENLVDDITET------------------------------AQTAGKIFREHL WNSKKQL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SSDISSD-GER--EANMPGLNIRNK EFN--Y----------LHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFA AHPE--HQSSDSTFLVFMSHSIL-------NGICGTKHWD--------QEPDVLHDDTIF EIFNNRNCQSLKDKPKVIIMQACRG-----NGA-GIVWFT-------TDS--GKAGADTH GRLLQGN-------------ICNDAVTKAHVEKDFIAFKSSTPH--NVSWRHETNGSVFI SQIIYYFR-------EYSWS-HHLE-----------EIFQKVQHSFETPNIL-------- ---TQLPTIERL----SMTRYFYLFPGN---------------- >R_norvegicus_ENSRNOP00000058685 ------------------------------------------------------------ ---------LTENNHPDKPLKVLEELGKEFLTE--YLEKLVQSN-VLKLKEE--EKQKFN NAERSDKRWVFVDVLKRK------------------------------HNQVGKMLLQTF LNVDSGSHHG-------------------------------------------------- ---------------------------------EANLEM--EEPEESVDTLK-------- ------------------------------------------------------------ -----------------LCSSEEFTRL----CREKKQEIYPI-KETN-GRTRKALIICNT EFK--H----------LSLRYGANIDISGMKGLLEELGYDVVVKEELTAEGMESEMKDFA ALSE--HQTSDSTFLVLMSHGTL-------QGLCGTMHSE--------ATPDVLLYDTIY QIFNNCHCPGLRDKPKVIIVQACRG-----GNP-GEVW-I-------RES--SGAHSYRA VDLPR-N-------------MEADAVRMSHVEKDFIALYSTTPH--HYSYTDWPRGSYXS SKCIFCLR-------MXTXT-VYLY-----------ELHNNVQQSFEKASIN-------- ---SQMPTIDRA----TLTRYFYLFPGN---------------- >G_aculeatus_ENSGACP00000013201 ------------------------------------------------------------ ---------YFSDKLKKVRTKFVEKASMSLIKQ--LLDDLLDNG-ILNDGQK--DSILEE NGTKADRARNLIDVVKAK------------------------------GNKASEILIASL ESRDSSLFSELGLS-------SAQTAPPAISGVSNIFKL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------VSPHRDRKLT----PLKSVFQIYPA-SKNS-ISNRVALLITNI KFT--Y---------EIPNRNGAEKDEENMEILMKGLGYEVVKHRNLTAKAIDEALKEFA KHPK--LKKTDSVLVVLMSH-------------CGVDWKRE-------RKADEFPIDNIY KHLGPENCPALLDKPKIIIIQACRG-----GDE-GAVV-V-------RDGDGP--ALACD DAGEE-D-------------IEDDNLRLVNKEKDFSSLLSCTPD--TVSYRHPVNGSFLI QYVVEVFN-------TFARE-DHVE-----------ELFRKVMQRFEDFPIQ-------- -REKQMPTKDRC----TLTKHFYFFPGL---------------- >T_rubripes_ENSTRUP00000013027 ------------------------------------------------------------ ---------MAICQLDSIRLMFVEKVSTQMINQ--LLDDIFMDG-IVSEMEK--ESITEE SNIRSDKARRLIDLVRKK------------------------------GERACKKMISHI QSRDPELSAVLGLS-------CGHPAPP--------GELR-------GQLESPAF----- -------------------------------------ST--AEPQMEGQGSS-------- ------------------------------------------------------------ -----------------STP-PSIDVF----WKEKQSDVYPG-TREA-INNRVALVITNI TFF-----------------QGAEKDEENMETLLKGLGYEVVKYRNLTGRAIEDAVIDFS KRPK--LKDTDSVVVVIMSHGRL-------GVVAGVSTQSPT------FEDDHFSLDKMY RLLGPEHCPALLNKPKIIIIQACRG-----DER-GEII-F-------NDQHPPENPPVSD DAN-----------------IQEDAIRIEHKEKDFVSLLSCTPD--TVSYRALAKGSFLV QVLVDVFN-------ASVER-DDLE-----------ELFRKVQHRFEDFPIG-------N R--RQMPTKDRC----TLTKRFYFYPGL---------------- >T_rubripes_ENSTRUP00000035020 ------------------------------------------------------------ ---------ME-DKLTSIRLMFVEKVSTQMINQ--LLDDIFMDG-IVSEMEK--ESITEE SNIRSDKARRLIDSVRKK------------------------------GERACKKMISHI QSRDPELSAVLGLS-------CGHPAPPVFNRRAPDGRSR-------VIFNSPINR---- ---------------------------------CVLEGE--TERQRRERALK-------- ------------------------------------------------------------ -----------------ISP-GNHSLL----LQSFQ--VYPG-TREA-INNRVALVITNI TFF--H---------QCLNRKGAEKDEENMETLLKGLGYEVVKYRNLTGRAIEDAVIDFS KRPK--LKDTDSVVVVIMSHGRL-------GVVAGVSTQSPT------FEDDLFSLDKIY RHLGPEHCPALLNKPKIIIIQACRG-----DER-GEII-F-------NDQHPPENPPVSD DAN-----------------IQEDAIRIEHKEKDFIWLLSCTPD--TVSYRALAKGSFLV QVLVDVFN-------ASAER-DDLE-----------ELFRKVQHRFEDFPIG-------N R--RQMPTRDRC----TLTKRFYFYPGL---------------- >T_rubripes_ENSTRUP00000019853 ------------------------------------------------------------ ---------LP-DQLASIRPMFVEKVSTQMINQ--LLDDIFMDG-IVSEMEK--ESITEE SNIRSDKARRLIDSVRKK------------------------------GERACKKMISHI QSRDPELSAVLGLS-------CGHPAPP--------GELRDDTLFQTDRIVSFRF----- -------------------------------------QP--QSPRWKVKGHL-------- ------------------------------------------------------------ -----------------QLPHQSMCSG----RRNRATKVYPG-TREA-ISNRVALVITNI TFF--H---------QCLNRKGAEKDEENMETLLKGLGYEVVKYRNLTGRAIEEAIIDFS KRPK--LKDTDSVVVVIMSHGRM-------GVVAGVSTLSKT------FEDDLFSLDKIY RLLGPEHCPALLNKPKIIIIQACRG-----DEG-GEII-C-------NDQHPPENPPVSD DAN-----------------IQEDAIRIEHTEKDSICFFSCTPN--TVSYRSPAKGSFLV QFLVDVFN-------ASAER-DDLE-----------ELFRKVQRRFEDYSIG-------D RSLRQMPAKDRG----TMTKRFYFYPGL---------------- >A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AMQIYPI-GDRR-SRTRLALIICNI TFA--H----------LNKREGAEVDLRGMTLLLEDLGYRVEIKINLTAKEMSTCLKDFA AREE--HKTSDSTFLVLMSHGVR-------DGLCGVQSRD--------KDSDVLPIDDVF SIFNNNNCRALYEKPKVVIIQACRG-----TNK-GVTY-V-------SDSVVPVVPSADS ASSSA-N-------------YEEDAVRMVHLESDFICLYSTT------------------ ------------------------------------------------------------ -------------------------------------------- >D_rerio_ENSDARP00000034228 ------------------------------------------------------------ -------------MAKSIKDHLQDALSNIGADNLRRFQSRLGDR---KQEPRVRKSTIEK LKDEIDLVDLLVNTF---------------------------------TSDAVSVTVDIL RGIKCNAVAEELLE-------NTGQVYSIFKLCKKNSHYTKPPIIITDVFMFCFLGGVSQ PEP------------------------------PVPEPI--PKDPAQLKELKVT------ ------------------------------------------------------------ -----------------PCSQQFKNKI----LREKGQETYEI-KDKS-VRKRLALLINNV DFD--D---------KAMKRSGSEKDEENMEKLLKELDYQVVKRPNLSAKEMDEAIRDFA QREE--HKYSDSAFVVIMSHGKR-------DAIMGVHYHRTN------NPSDSFPVDNVY RRLNSENCPALRDKPKVILIQACRG-----GEH-GRVW-A-------SDGEPDEP----- --------------------IEIEDDDFVHKEKDFISLMSCTPD--TKSYRHVQNGTFYV QTLVDVFI-------KCAHE-DHIE-----------ELFRKVLRRFEHPNMI-------- GNFKQMACKDRA----TLPKLFYLFPGL---------------- >O_latipes_ENSORLP00000007938 ------------------------------------------------------------ --------------------------------------MLLQDK-VLNDEER--ESICEE K-SRADMARSLIDTVRKK------------------------------GSTASKMMINHF EQKDPILFSELGLS-------CPEPAQT-------------------------------- --------------------------------------N--SHSQRDEPATT-------- ------------------------------------------------------------ -----------------VLTAEDFWK-----KTQNDPNVYPV-TKAS-YKSRVALMITNI KFS--N---------EKLNRAGAEKDEENMDRLLSKLGYEVVKHKSLTGKAINEAFIEFT KHPK--LKETDSVIVVLMSHGKL-------GAVLGVEWKHDD------ENPDEFPVNSIY EHLGPEKCPALLDKPKIIIIQACRG-----DQT-GSVC-I-------SDSGNQAEEFLHP AAAGD---------------LLEDNLRFVHKEKDFISLLSCTPD--TKAFRCRARGSHLI QYIVEIFN-------TDADT-LYIQ-----------ELFRKVMLRFESFAFK-------- -HNRQMATIERC----TLLKQFYFYPGLGDTNHS---------- >D_rerio_ENSDARP00000059407 ------------------------------------------------------------ -------------KMEDITKLITDVLEELVESE---LKEFKRQLWMGVKKGV--EAIPRG KLENKDRQDVVDYMVQHY------------------------------SMDAGKIAVQAL RSIKQNERANRLESKLLEAVSSSDLFQPQAQENEQNPEDPQSINT--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SGFQEFKTRL----LYANRDDIYTP-VSRT-QRKGLALLITNI LFA--N---------KQDDRAGAERDEENMEWLLKNLNFMVIKYRNLTGNEISRAVQDFS RRHE--HQDADSTFVVIMSHGDR---IQNKDAILGVNYNWLQ------NRNDVYFVEDTF SHLNSVNCPALIDKPKVILIQACRG-----GQL-GGVP-V-------KDCVPE------- ------------------------SDSWVHKEKDFVCFMSTMPD--VVAYRDEVKGSYFI SYIVDVFC-------SSACK-DHIM-----------ELFRKVAARMEKDERF-------R RQAKLLPCIERT----SLVKKFYLFPGQ---------------- >D_rerio_ENSDARP00000068268 ------------------------------------------------------------ --------------MEDITQLLSDVLEDLVESE---LKQFTRQLWIGVKPGV--EPIPRG KLENKDRQDVVDSMVQQY------------------------------SEDAGTITVQTL RKIKQNERAKRLESNLLKV-------QSQGQENKQNSEEPQPIPQIISQPIQQIISQP-- ---------------------------INNAGSEDLQPI--QADWQRPRQII-------- ------------------------------------------------------------ -----------------PCSQETKNTL----LKAHGDDIYTP-RSGT-QRKGLALLITNI QFA--N---------TQHNRNGADRDEENAEWLLRSLGFAVIKYRNLSGKDIRRAVENFS KRRE--HEDADSTFIVIMSHGTR---IDNKDAIVGVS-------------DDVYFIEETF SHLNSVNCPALIDKPKVILIQACRG-----GQS-SGVL-A-------QDSVFA------- ------------------------SDSWVHMEKDFVCFMSTMPN--TFAYRNPIEGSFFI SYIVDVFC-------SSAHR-DDIM-----------ELFRKVTLRMEKDQRF-------Q GQAKLLPCIERT----SISKRFYLFPGL---------------- >D_rerio_ENSDARP00000008601 -----------------------------------------------MTEEVNWDEDLEV DAVVQNLNLYKTVMRNDKNSNSEVQLSNELVDF--AVELTCGHRMPVDYVVAWFKCYLKQ KETDFSCPHFIVDQGKTC------------------------------GAKLSYQEICQL IPLSDKQREFLEENLAAI---VARRLFDFKSCPGCQSHVERRNRNNLCVKCTICTANMTQ TYYFCWKCRREWK-------GV-----TNNAECCGNTGC--GQSVTEPDPLK-------- ------------------------------------------------------------ -----------------PCTPEFKAEK----LMTEGKCIYPV-KDKSPQRKRLALLINNV DFK--D-----------NVRTGADKDELSMERLLKGLGYSVVTLRDLSAQGMSTAMRDFS QRKE--HADSDSCFVVLMSHGDE-------SGICGIFDSS--------SQDDVFPPDEIF KYLNTPNCAGLRDKPKIILIQSCRG-----GKP-GNVD-V-------PDS---------- --------------------VPIRGTRREHKEKDFCCFRSSTPV--TVS----------- ------------------------------------DPLLQGK----------------- -------------------------------------------- >P_troglodytes_ENSPTRP00000047673 ------------------------------------------------------------ ---------MADKVLKEKRKLFIHSMGEGTING--LLDELLQTR-VLNQEEM--EKVKCE NATVMDKTRALIDSVIPK------------------------------GAQACQICITYI CEEDSYLARTLGLS-------AAPQAV--------------------------------- ---------------------------------QDNPAM--PTSSSPEGRIK-------- ------------------------------------------------------------ -----------------LCFLEDAQRI----WKQKLQRCHVQ---NT-------IIKWSE RYT-----------------SGS----FEMQWLFLRTNF----------------IERFW RI---------------------------------------------------------- ----------------ILLLPLHKG----------------------------------- ------------------------------------TLYPRIPG---------------- --LGKELQ---------------------------------------------------- ----------------TGTHKLS--------------------- >H_sapiens_ENSP00000364858 ------------------------------------------------------------ ---------MADKVLKEKRKLFIHSMGEGTING--LLDELLQTR-VLNQEEM--EKVKRE NATVMDKTRALIDSVIPK------------------------------GAQACQICITYI CEEDSYLAETLGLS-------AALQAV--------------------------------- ---------------------------------QDNPAM--PTCSSPEGRIK-------- ------------------------------------------------------------ -----------------LCFLEDAQRI----WKQKLQRCHVQ---NT-------IIKWSE RYT-----------------SGS----FEMQWLFLRTNF----------------IERFW RN---------------------------------------------------------- ----------------ILLLPLHKG----------------------------------- ------------------------------------SLYPRIPG---------------- --LGKELQ---------------------------------------------------- ----------------TGTHKLS--------------------- >X_tropicalis_ENSXETP00000015203 ------------------------------------------------------------ -----MLGGMQKHHKDALQRLRVTLLHDMIIEE--LVEHLVSSG-ILTPIMH---STIMA HRSEYKQNVTLLTQLPKR------------------------------GPRAFSEFCNAL HATGQRHLAEQLEEE------AQQQQ---------------------MESVTPEVHERSF PLP---------V-------QE-----STP--------------SRPRRQFCR------E YNEE-------------------------------------------------------- -----SIDDGDGPGT----VQLCSVDF----YLSHHQQAYKM---HS-CPRGRALIISNV AFE----------TQDLDHRYGGEVDVTSLEKLFSSLGFQVEVRRNLNAQNMMSQLGAFS ALPA--HSALDSCVVAVLSHGLD-------GAVYGTD-------------GKLVQLQDVF TAMDNAHCPQLQNKPKMFFIQACRG-----EEA-DRGVDQ-------RDGREQSASPGCE Q-SDAGR---------------EDIKVRLPTQSDMICAYACLKG--TVSLRNTKRGSWFV QDLVSVFS-------QYSKN-THVA-----------DMLVKVNALIKEREGH--APGTEF HRCKEMSEYCS-----TLCRDLYLFPG----------------- >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ---------MADQLLENLRPDLIKGLSERVING--LLDDLQQKK-VFGEEEI--EDIQHR MKTRADQARHVIDDVKRK------------------------------GVKASEIMLASL KTRDPHLYDTLGIERLLVPVPETELTPS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QLSETTGCST----DKTNTMNEYEM---KS-NPRGLCLIFNNE NFK-----------DPDMKRHGSQMDTASLKDLFEWLGFSVEIKQDQTVSAMKRTLKEYS E--D--RKHGDCFVCCVLSHGNE-------SGVLGSD-------------EKICPVDDIT SPFNGANCSSLAGKPKVFFIQACRG-----HEI-QSKVMV-------ADGSGG------- --SRTQK--------------PGRVSVSIPKDSDFLIARSTVEG--YVSIRDRTSGTWFI QSLCENLK-------EGSKRGHDIL-----------MILTKVNNDVSRKEGS-LKVKNEI VDAKVTPQPIF-----TLRKLLIFRPLKKTGRFS---------- >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ -------CGMQERDRLALRTRSTVLCKQLVVDE--LLIQSLQTDEILTEAMA---ENIMA EQTSQKRSWRLLLLLPKR------------------------------GPRAFSSFCSAL QETEQQHLYELLIQSSE----KDGKE-----TPG-------------ML-MCGQFIDSSL PLP---------T-------QE-----VVA--------------AK-RARTQ-----A-E SMEF-------------------------------------------------------- -----SLD-ADSPIN--SPVLPCTPDF----YLSHCHQSYRM---NS-SPRGFALVISNV TFDPCA-------APDLDPRKGGEVDDEVLRKVFTELDYVVKVHRDLTAQDMRTCIEEFS RRPD--HRTMASCVVCLLSHGVE-------GAIYGTD-------------GQLLKLDWVF ESFDNAHCPLLQNKPKMFFIQACRG-----EEM-DCGVEQ-------IDGPVRTCSPSCE Q-RDAGREGQGD-ASARQRGDMG--RIKLPQRSDMICGFASLKG--TAAMRNTKRGSWFV QELNKRLR-------LHARD-THLA-----------DIMVQVNRHIKEREGY--APGTAH HRCKEMSEFTS-----SLCKDLYLFPKYQPQ------------- >M_musculus_ENSMUSP00000031895 --------------------------------------MAAPSGRSQSSLHRKGLMAADR RSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KGGSFSQNVELLNLLPKR------------------------------GPQAFDAFCEAL RETRQGHLEDLLLTT------LSDIQ---HVLPP-----------------LSCDYDTSL PFS---------V-------CE-----SCP--------------PHKQLRLS-----T-D ATEH-------------------------------------------------------- -----SLDNGDGPPC--LLVKPCTPEF----YQAHYQLAYRL---QS-QPRGLALVLSNV HFT--G-------EKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFA QLPA--HRVTDSCVVALLSHGVE-------GGIYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHTQSPGCE E-SDAGK--------------EELMKMRLPTRSDMICGYACLKG--NAAMRNTKRGSWYI EALTQVFS-------ERACD-MHVA-----------DMLVKVNALIKEREGY--APGTEF HRCKEMSEYCS-----TLCQQLYLFPGYPPT------------- >B_taurus_ENSBTAP00000024166 --------------------------------------MAAPSAGFQYPLQPKEQMAADR GRRMLRGCGMHPDHQEALKKNRVVLAKELLLSE--LLEHLLEKD-IITLEMR---EHIQA KTGSFGQNVELLNLLPKR------------------------------GPQAFDAFCVAL RETKQSHLEELLLRT------LSGLQ---PVVPP-----------------LSCDYDLSL PFP---------V-------CE-----SCT--------------RHKRLHLS-----P-D AVEH-------------------------------------------------------- -----SLDHGDGPPC--LQVKPCTPEF----YQTHHHLAYRL---QS-RPRGLALVLSNV HFT--G-------EKDLEFRSGGDVDHSTLVTLFKLLGYKVHVLLDQTAQEMQEKLQNFA QLPV--HRVTDSCIVALLSHGVE-------GGVYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDL-------QDGKNHDRSPKCE E-SDASR--------------EELLKMRLPTRSDMICGYACLRG--TAAMRNTKRGSWYV EALTQVFS-------ERACD-MHVA-----------DMLVKVNALIKEREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >E_caballus_ENSECAP00000003321 --------------------------------------MAAPSAPSLPALQQKGLMAADR GRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVTSFGQNVELLNLLPKR------------------------------GPQAFEAFCVAL RETKQGHLEDLLLTT------LSGLQ---HVLPP-----------------LSCDYDLSL PFP---------V-------CE-----SCP--------------PHKQLRLS-----T-D TVEH-------------------------------------------------------- -----SLDNGDGPPC--LQVKPCTPEF----YQAHYQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKDLEFRSGGDVDHSTLVTLFKLLGYNVHVLLDQTAKEMQEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAKSPECE E-SDAGK--------------EELLKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALTQVFS-------ERACD-MHVA-----------DMLVKVNALIKEREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >R_norvegicus_ENSRNOP00000022672 --------------------------------------MAASSGRSQSSLHRKGLMAADR RSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KGGSFSQNVELLNLLPKR------------------------------GPQAFDAFCEAL RETRQGHLEDLLLTT------LSDIQ---HILPP-----------------LSCDYDSSL PFS---------V-------CE-----SCP--------------PHKQSRLS-----T-D TMEH-------------------------------------------------------- -----SLDNGDGPPC--LQVKPCTPEF----YQAHYQLAYRL---QS-QPRGLALVMSNV HFT--G-------EKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAQSPGCE E-SDAGK--------------EELMKMRLPTRSDMICGYACLKG--NAAMRNTKRGSWYI EALTQVFS-------ERACD-MHVA-----------DMLVKVNALIKEREGY--APGTEF HRCKEMSEYCS-----TLCQQLYLFPGYPPT------------- >C_familiaris_ENSCAFP00000005409 --------------------------------------MAAASAGRPAALQRKAPTAAGR GRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---EHIQA KVGGFSQNVELLNLLPKR------------------------------GPQAFDAFCVAL RETKQGHLEDLLLTT------LSGLQ---HGLPP-----------------LSCDYDLSL TFP---------M-------CE-----SCP--------------PQKQLRLS-----P-D TVEH-------------------------------------------------------- -----SLDNGDGPPC--LQVKPCTPEF----YQTHYQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKDLEFRSGGDVDHSTLVTLFKLLGYKVHVLLDQTAQEMKEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKLLQLQEVF RLFDNASCPNLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHTGSSECE E-SDASK--------------EELLKTRLPTRSDMICGYACLRG--TAAMRNTKRGSWYI EALTQVFS-------ERACD-THVA-----------DMLVKVNALIKEREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >G_gallus_ENSGALP00000029853 ------------------------------------------------------------ -----GACGMQRYHQEALKKNRVMLARELVLKE--LMEHMIEKD-IITIEMV---EMIQA KSGSFSQNVEFLNLLPKR------------------------------GPNAFSAFCEAL QETKQQHLAEMILKT------ESSLR---HGIAT-----------------LEQRYGSNL PLP---------L-------SE-----SCN-----------SKRPRLIVFFC-----T-K PVEH-------------------------------------------------------- -----SLDSGDGPPI--PPVKHCTPEF----YRDHQHLAYKL---IS-EPRGLALILSNI HFS--S-------EKDLEYRSGGDVDCASLELLFKHLGYQVTVFHDQSAEEMESALERFS KLPD--HQDVDSCIVALLSHGVE-------GGVYGTD-------------GKLLQLQEAF RLFDNANCPNLQNKPKMFFIQACRG-----DET-DRGVDQ-------RDGKEWSDSPGCE E-SDANK--------------EENLKLRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALTTVFA-------EDSRD-THVA-----------DMLVKVNRQIKQREGY--APGTEF HRCKEMSEYCS-----TLCRDLYLFPGYVPGK------------ >C_elegans_C48D1.2 ------------------------------------------------------------ --------MMRQDRRSLLERNIMMFSSHLKVDE--ILEVLIAKQ-VLNSDNG-DMINSCG --TVREKRREIVKAVQRR------------------------------GDVAFDAFYDAL RSTGHEGLAEVLEPLARSVD-SNAVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSS VSSFTSYQDIYSR-------AR-----SRSRSRALHSSD--RHNYSSPPVNAFPSQPSSA NSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEED------------------------- -----------------MNFVDAPTIS----RVFDEKTMYRN---FS-SPRGMCLIINNE HFE------------QMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFA KHES--H--GDSAILVILSHGEE-------NVIIGVD-------------DIPISTHEIY DLLNAANAPRLANKPKIVFVQACRG-----ERR-DNGFPVLDS----VDGVPAFLRRGWD N-RDGPLFNFLGCVRP----QVQQVWRKKPSQADILIAYATTAQ--YVSWRNSARGSWFI QAVCEVFS-------THAKD-MDVV-----------ELLTEVNKKVACGFQT----SQGS NILKQMPEMTS-----RLLKKFYFWPEARNSAV----------- >H_sapiens_ENSP00000312664 --------------------------------------MAAPSAGSWSTFQHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVGSFSQNVELLNLLPKR------------------------------GPQAFDAFCEAL RETKQGHLEDMLLTT------LSGLQ---HVLPP-----------------LSCDYDLSL PFP---------V-------CE-----SCP--------------LYKKLRLS-----T-D TVEH-------------------------------------------------------- -----SLDNKDGPVC--LQVKPCTPEF----YQTHFQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKLLQLQEVF QLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAGSPGCE E-SDAGK--------------EKLPKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALAQVFS-------ERACD-MHVA-----------DMLVKVNALIKDREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >P_troglodytes_ENSPTRP00000033921 --------------------------------------MAAPSAGSWSTFQHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVGSFSQNVELLNLLPKR------------------------------GPQAFDAFCEAL RETKQGHLEDMLLTT------LSGLQ---HVLPP-----------------LSCDYDLSL PFP---------V-------CE-----SCP--------------LYKKLRLS-----T-D TVEH-------------------------------------------------------- -----SLDNKDGPVC--LQVKPCTPEF----YQTHFQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKLLQLQEVF QLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAGSPGCE E-SDAGK--------------EKLPKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALAQVFS-------ERACD-MHVA-----------DMLVKVNALIKDREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >T_guttata_ENSTGUP00000013612 ------------------------------------------------------------ ---MLAACGMQRCHQEALKKNRVMLAKQLVLNV--LVEHMVEKD-IIPTEMV---EMIQA KSGSFDRNVEFLNLLPKR------------------------------GPNAFSAFCEAL RETQQQHLETLILKT------MSSLS---QEIAR-----------------LEHCHESDL PYP---------A-------SE-----SCN-----------SKRPRWL-----------E PMEH-------------------------------------------------------- -----SLDNRDGPSI--PPVKYCTPEF----YHNHQHLAYKL---TS-EPRGLALILSNV RFS--S-------EKDLEYRAGGDVDCASLEMLFRHLGYRVTVFCDQTAQDMQNALERFS KLQD--HRDVDSCIIALLSHGVE-------GGVYGSD-------------GKLLELQETF RLFDNANCPNLQNKPKMFFIQACRG-----DEL-DRGVDQ-------RDGKGRSDSPGCE E-SDANK--------------EESLKLRLPTCSDMICGYACLKG--TAAMRNTKRGSWYV EALTSVFA-------EDSQH-THVA-----------DMLVKVNRQIKQREGY--APGTEY HRCKEMSEYCS-----TLCRDLYLFPGYLPGK------------ >M_mulatta_ENSMMUP00000016588 ------------------------------------------------------------ --RILGVCGMHPHHQETLKKNRVMLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVGSFSQNVELLNLLPKR-------------------------------PQAFDAFCEAL RETKQGHLEDIELKL------RVSAL---MKPTG-----------------LGSDYNDIL GLM---------V-------KL-----NT---------------VFWFSVYT-----T-D TVEH-------------------------------------------------------- -----SLDNKDGPVC--LQVKPCTPEF----YQTHFQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKELEFRSGGDVDHSTLVTLFKLLGYDVHVLRDQTAQEMQEKLQNFA RLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAGSPGCE E-SDAGK--------------EKLPKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALAQVFS-------ERACD-MHVA-----------DMLVKVNALIKDREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >P_pygmaeus_ENSPPYP00000020323 --------------------------------------MAAPTAGSWSTFEHKELMAADR GRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVGSFSQNVELLNLLPKR------------------------------GPQAFDAFCEAL RETKQGHLEDMLLTT------LSGLQ---HVLPP-----------------LSCDYDLSL PFP---------V-------CE-----SCP--------------LYKKLRLS-----T-D TVEH-------------------------------------------------------- -----SLDNKDGPVC--LQVKPCTPEF----YQTHFQLAYRL---QS-RPRGLALVLSNV HFT--G-------EKELEFRSGGDVDHSTLVTLFKLLDYDVHVLCDQTAQEMQEKLQNFA QLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKLLQLQEVF QLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNHAGSPGCE E-SDAGK--------------EKLPKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALAQVFS-------ERACD-MHVA-----------DMLVKVNALIKDREGY--APGTEF HRCKEMSEYCS-----TLCRHLYLFPGHPPT------------- >M_domestica_ENSMODP00000001598 ------------------------------------------------------------ --RMLGVWGMEQEHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA KVGSFSQNVEFLNLLPKR------------------------------GPHAFEAFCDAL RETKQGHLEDLLHRT------LYSFQ---NLRPP-----------------LGCDYDSSF PLP---------V-------CD-----SCP--------------PHKQLRLS-----V-E TMEH-------------------------------------------------------- -----SLDNGDGPPS--LQVKPCTPEF----YQTHQHLAYRL---QS-RPRGLAMVLSNV HFN--G-------EKDLEFRSGGDVDHSSLVTLFKLLDYDVHVLRDQTAQKMQENLQRFA QLSA--HQSTDSCMVALLSHGIE-------GGIYGVD-------------GKLLQLQEVF RLFDNANCPNLQNKPKMFFIQACRG-----DET-DRGVDL-------RDGKEHVASPGCE E-SDAGK--------------EKILKMRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALTQVFS-------ERARD-MHVA-----------DML--VNALIKDREGY--APGTEF HRSKEMSEYSS-----TLCRHLYLFPGHPPT------------- >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ ---------MQPCHQEALKKNRVALAKQLMLSE--LLEHLLEKD-VITMEMR---ELIQA KAGSFSQNVEFLNLLPKR------------------------------GPKAFDAFCAAL RETKQGHLQDLLYRT------LSNLS------PPSTAVGALGTQGEELAGRLGGRWRGLP SLP---------S-------VS-----VCPVVVCPFLMV--LGNSRLQPALSVGDLLP-E EMEH-------------------------------------------------------- -----SLDNGDGPPC--PQVKPCTPEF----YRVHHHLAYRL---ES-RPRGLALVLSNM RFN--G-------EKDLEFRSGGDVDHNALITLFKHLDYSVEFLRDQTAQEMQEKLHNFA QSPR--HRFTDSCVVALLSHGVE-------GGIYGVD-------------GKLLQLQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------RDGKERAASPGCE E-SDAGK--------------EEMLKVRLPTRSDMICGYACLKG--TAAMRNTKRGSWYI EALTQVFA-------ESARD-MHVA-----------DMLVKVS----------------- -------------------------------------------- >D_rerio_ENSDARP00000083664 ------------------------------------------------------------ ---MLGECGMTKWERLALRRNSVKMLQDLVVDD--LLIQCLQQDGILTDSMA---ESIMA KPTSQGRSHQLLFLLPKR------------------------------GPRAFSTFCSAL KETEQHHLCKLLMDFTE----KDKKNSQYKLSPE-------------ICKKKNKHTHTH- -----------------------------------------------------------K SMEM-------------------------------------------------------- -----CLD-ADSPVT--TAVLPCTPEF----YQSHRPQAYPM---RS-CPRGLALVLSNV RFD-SA-------NTDLDIRRGGEVDEETLRRLFTELDFKVSLHRDLTAEAMRRCLEQFA QQQE--HAAYDCAVVCLLSHGVE-------GSVYGTD-------------GQLLELDWVF EVFDNARCPLLQNKPKMFFIQACRG-----EEM-DNGVDQ-------LDGQERTQSPGCE Q-RDAGREGERDNREKKEEKERERLRVKLPQRSDMICGFATLKG--TAAMRNTKKGSWFI QELNTAIR-------QRANN-THLS-----------DILVQVNGQIKSREGY--APGSAH HRCKEMSEFTS-----SLCKDLYLFPKYYPSN------------ >A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------ -SRMLGVCGMQKCHQEALKKNRVSLAKQLVLKE--LMEHLIEKD-VITEEMM---EMIQA KAGNFSQNIEFLNLLPKR------------------------------GPKAFSAFCEAL RETKQPHLEEMLLLN------LIDFLLFHHVIVP--------------------PQNAHL PLHT--------V-------CD-----LLP--------------FAYQLFIS-----SAE PMEH-------------------------------------------------------- -----SLDDGDGPHY--PQVMPCTPEF----YRTHEQLAYKL---KS-QPRGLALILSNI HFN--K-------ETDLDFRSGGDVDNTALHMLFKHLGYQVVVRQDRTAQEMKEELEIFS KHPA--HRNVDSCIVSLLSHGIE-------GGIYGID-------------GKLLQLQEIF RLFDNANCPNLQNKPKMFFVQACRG-----DET-DHGVDQ-------IDGNDRASSPGCE E-TDANK--------------KENPKLRLPTCSDMICGYACLKG--TAAMRNTKHGSWYV EALTSVFA-------EDSGH-MHVA-----------DMLVKVNRLIKLREGH--APGTEF HRCKEMSEYCS-----TLCQDLYLFPGYFPG------------- >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ ---------MNEADRLLLRRYRVRLVGELQVAS--LWDALLSRE-LFTPDMI-EDIQRAG SGSRRDQARQLILDLETR------------------------------GSQALPLFISCL EDTGQDTLASLLKTS------RQAAKQ--------------------------------- ----------SKP-------SQ-----GKLAPVVLGPEE--LWPAKLRPEVLR----PEV PRAVDAGSG--------------------------------------------------- -----------------GFTDVCPQDR----AKGNADLAYVL---NA-DPCGHCLIINNV NFC--R-------ESGLRARTGSNIDCERMRQRFHLLQFVVEVKCDLTAKQMVQALMQLA RQ-D--HSALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSVERIV NTFNGTGCPSLRGKPKLFFIQACGG-----EQK-DHGFEVE------STSPEDKTPSSDP E-ADATPFQE--GPRSI---DEPDAVSSLPTPSDILVSYSTFPG--FVSWRDPKSGSWYI ETLDSIFE-------QWAHC-EDLQ-----------TLLLRVANAVSVK----------- GIYKQMPGCFN-----FLRKKLFFKT------------------ >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ AGTRRDQARQLVTDLETR------------------------------GRRALSVFISCL RETDQHALAALLSEG------CQAPQVTPV--DIRPVEIIRPGGQGDVCKYSKIHPKCYS PPLPFQSTSPLRG-------KE-----QWTGSVKPFVPV--PSTTK-------------- ------------------------------------------------------------ -----------------REQEATRPGE----KQGMAIKVYSL---KS-EPCGHCLIINNV DFS--L-------GSGLSTRTGSDVDCEKMKRRFRLLHFEVAVERNLTAEEMVKALNKLA KK-D--HSALDCCVVVILSHGYQASHIQFPGGIHGTD-------------GESISVETIV NYFNGSRCPSLGGKPKLFFIQACGG-----EKK-DPGFEVN------LDSPEDHPTGSDP E-SDAAPFQA--APEDY---DEPDAVASLPTPSDILVSYSTFPG--FVSWRDTQSGSWYI ETLDSVLD-------QWAHT-EDLL-----------TLLLRVSNGVSSK----------- GKYKQIPGCFN-----FLRKRLFFNTK----------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ ---------MDEAERRALRRCRVRLVRELQVAA--LWDALLSRE-LFTAAMV-EDLQHAG SGSRSDQARQLVIDLETR------------------------------GSQALPLFISCL EDTGQDALASCLTMS------RQAVKQNPE--ATRPLD-LMPVVLGPTRLTPEDLR---- ------GKDPSKL-------TP-----GKLAPVVLG-------PAELQPQVVR----PSV PRPTDNGSG--------------------------------------------------- -----------------RFSDVCEYQESGWWVAGPIKLAYAL---NA-DPCGYCLIINNV NFC--P-------ESRLTARGGSNIDCEKLQRRFCLLRFTVEVKWDLTAKQMVQALVELA RR-D--HSALDCCVVVVLSHGCEASHRQFPGAVYGTD-------------GCPVSIEKIV NIFNGTGCPSLGGKPKLFFIQACGG-----EQK-DHGFAVA------SASPEDRSPGSDS E-PDAVPFQE--GPGPF---DQLDAVSSLPTPSDIFVSYSTFPG--FVSWRNTKSGSWYV ETLDGVFE-------QWAHA-EDLQ-----------TLLLRVANAVSQK----------- GVYKQIPGCFN-----FLRKKLYFKM------------------ >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AFEPYK---KH-KNIGKCLIISNE HFP--V-------QFSLNRKKGNSVDERRLSSTFKSLGFHVKVENNLSANQMIDALRTVS EE-D--HTDNSCFVCVLMSHGEE-------GTILGSD-------------ERWIPVKTLT SLLTSDLCPSLRDKPKIFFLQACRG-----VEY-DPGV--E------ADS-VEAS----E D-FF-------------------G-ISDVP-ELDFLCCYSTVEG--YFAWRNPETGSIFI RELCKTLM-------DC--R-LEII-----------QILTRVNHLVAYYFQS-YTLELET NRKRQMPCFAS-----RLTKDFYLHV------------------ >O_cuniculus_ENSOCUP00000001859 --------------------------------------MAAPSAGSRASLQQKGLLAADR GRRITAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMR---ELIQA RVGSFSQNVELLNLLPKR------------------------------GPQAFDAFCVAL RETKQGHLEDLLLTT------LSGLQ---HVLPP-----------------LSCDYDLSL PFP---------V-------CE-----SCS--------------PHKQPRLS-----T-E TEER-------------------------------------------------------- -----SLDNGDGPPC--LQVKPCTPEF----YQTHYQLAYRL---QS-RPRGLALVLSNV RFT--G-------EKDLEFRSGGDVDHSTLIALFKLLGYNVHVLHDQTAQEMREKLQNFA QLPA--HRVMDSCIVALLSHGVE-------GGIYGVD-------------GKLLELQEVF RLFDNANCPSLQNKPKMFFIQACRG-----DET-DRGVDQ-------QDGKNQAGSPGCE E-SDAGK--------------EP-LKMRLPTRSDMICGYACLK----------------- ------------------------------------------------------------ -------------------------------------------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ ---------MNEADRQLLRRSRLRLVRELQVDS--LWDALLTRE-LFTPDMI-EDIQR-- SGSRRDQARQLIIDLETR------------------------------GSQALLLFISCL EDTGQDTLASFLRTS------SQAAKQNPE--AIRPSD-LPPVVLGPVGLKPEELTA--- -----VKQDPSKL-------TP-----GKLTPVVLGPEE--LWLAKLRPEVLR----PEV PRPVDIGSG--------------------------------------------------- -----------------GFSDVRAQDR----LRGNADLAYVL---NA-DPCGHCLIINNV NFY--L-------ASGLGRRVGSDIDCEKLRQRFSLLHFMVEVKGDLTAKQMLRALGELA RR-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSIESIV NIFNGTGCPSLGGKPKLFFIQACGG-----EQK-DPGCKVD------STSPEDRTPGSDS E-PDAVPFQE--GPGTF---DQPDAVSSLPTPSDIFVSYSTFPG--FVSWRDPKSGSWYV ETLDGVFE-------QWAHS-EDLQ-----------TLLLRVAHAVSEK----------- GVYKQIPGCFN-----FLRKKFFFKTY----------------- >T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------ -RSKMLHCGMREQDARTLRRQSAVLCKQLVVDE--LLIQCLQADDILTESMA---ESIMA EQTSQKRSWRLQLLLPKR------------------------------GPKAFSSFCSAL RATDQQHLCDLLTQTFE----TNGNG-----------------------THVETCVDSSV PLP---------T-------QE-----AVP--------------GVCVCVCE-----T-E SLEV-------------------------------------------------------- -----SLD-ADSPIN--TPVLPCTPDF----YLSHFQQSYKM---AS-SPRGFALVISNV TFNPCA-------APELDPRKGGEVDDEVLRKVFTELEYSVTVQRDLTAQGIKTCIQNFS GRPE--HRSVDSCVVCLLSHGVE-------GAVYGID-------------GELLQLDWVF EAFDNAHCPLLQNKPKMFFIQACRG-----DEM-DCGVEQ-------IDGPSRTSSPSCE Q-RDAGR--------------EGRPRIKLPQRSDMICGFASLKGQDSSHAEHQKRGSWFI QELNTALR-------LHARD-RHLA-----------DILVQVNRRIKDREGY--APGTAH HRCKEMSEFTS-----SLCKDLFLFPKYQPQ------------- >P_troglodytes_ENSPTRP00000056642 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEA AWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMI-EDIQRAG SGSRRDQARQLIIDLETR------------------------------GSQALPLFISCL EDTGQDMLASFLRTN------RQAAKL--------------------------------- ----------SKP-------TL-----ENLTPVVL-------RPEIRKPEVLR----PET PRPVDIGSG--------------------------------------------------- -----------------GFGDVGALES----LRGNADLAYIL---SM-EPCGHCLIINNV NFC--R-------ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKEMVLALLELA RQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSVEKIV NIFNGTSCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------STSPEDESPGSNP E-PDATPFQE--GLRTF---DQLDAISSLPTPSDIFVSYSTFPG--FVSWRDPKSGSWYV ETLDDIFE-------QWAHS-EDLQ-----------SLLLRVSAAFLCK----------- GEGRLLRGSVSSWGWGFGVSRAGPNQG----------------- >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ ---------MEERQRRALRRGRARLVAALRVEP--LWEPLEQRG-LFTRPML-EELQS-- AGSRGEQARQLIIDLETR------------------------------GKQAFPAFLSIL RDTGQGHLAEMLMQE------CESRPVPPQLPDLRPVELELQEANQRCAVVLQTAAR--- ------------------------------------------------------------ ----DVAAG--------------------------------------------------- -----------------IPLTVGKSPE----VMSFIILDYEM---KA-DPCGHCLILNNV NFC--R-------DSGLSTREGSDIDCEKLERRFKALCFTVLTRRDLKAQEMVLELLKLS RQ-D--HSALDCCIVVILSHGCQTSHIQFPGGVYGTD-------------GKPIPIEKIV NYFNGSSCPSLRGKPKLFFIQACGG-----EQR-DQGFVVD------CDSPKEEALGDSL E-SDAIPFRV--PSDNV---DEPDAIASLPTPSDILVSYSTFPG--FVSWREKSSGSWYV ETLDSVLE-------QYAHS-EDLL-----------SMLVRVAHAVSAR----------- GRYKQIPGCFN-----FLRKKFFFVCR----------------- >O_latipes_ENSORLP00000015114 ------------------------------------------------------------ -RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDE--LLIQALVKDGILTQNMA---ESIMV QKTSHHRSFKLLLLLPKR------------------------------GPRAFKSFCSAL KETEQEHLCDLLTQE------EEGRE-VCLDTPL-------------INSEEQSEVSSSM SYP---------I-------HD-----SEG--------------LQLEMRTN-----T-E SMES-------------------------------------------------------- -----SLD-ADSPIN--TPVLACSADF----YLSHCQQSYRM---NS-SPRGSVLVISNI NFDPRA-------APELDPRKGGEVDDEVLRKLFTELDYSVNFHRDLTAQDMKMVIENFC RRPD--HQKVDSCVVCLLSHGVD-------GAIYGTD-------------GQQLALDWVF EAFDNAHCPLLQNKPKMFFIQACRG-----DEM-DCGVEQ-------IDGPARTFSPTCE Q-RDAGREEQGD-ADGRQRASTGRQRIKLPQRSDMICGFASLKG--TAAMRNTKKGSWFI QELNTALR-------LNARD-THLA-----------DILVQVNKRIKEREGY--APGTAH HRCKEMSEFTS-----SLCKDLYLFPKYQPQC------------ >D_melanogaster_FBpp0071971 ------------------------------------------------------MTDECV TRNYGVGIRSPNGSENRGSFIMADNTDAKGCTP-------------------------ES LVVGGATAASPLPANKFV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ARM----PVERYASEYNM---SH-KHRGVALIFNHE FFD----------IPSLKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDILKHVGKAA EL-D--HTDNDCLAVAILSHGEH-------GYLYAKD-------------TQ-YKLDNIW HYFTATFCPSLAGKPKLFFIQACQG-----DRL-DGGITLE------KGV---------- --TETDG-------------ESST-SYKIPIHADFLFSYSTIPG--YFSWRNINNGSWYM QSLIRELN-------ANGKK-YDLL-----------TLLTFVNQRVALDFESNVPATPMM DRQKQIPCLTS-----MLTRILRFGDKPNGNKAG---------- >C_intestinalis_ENSCINP00000002956 ------------------------------------------------------------ --------AMKKRHRNTLIKNRVKLAKCLHLDE--VLQYLVQCG-ILTDVTV---ERITS KPTRFSQNVAFLTCLPTR------------------------------GPRAYGTFLEAL RISSQEHLVDILEKV------DISNAIPNNKPITPTTLHATITSNVHSEFVCARRQPMEI GKCEDKNDAKDGH-------NR-------------------------------------- ------------------------------------------------------------ -----------------LRVQNSTVAF----FNETYNSGYKM---TT-KSRGYALIVCIG RFN--A-------GVRLPDRQGTDADKKNLLAIFEQINYKTILVENCNKFEMERRVKQFA QMEE--HRKCDSCAVAILSHGSK-------TDIYASD-------------GRSIPIESLI KMFDNVNCPPLRNKPKIFFIQCCRG-----NNM-DQGIDA-------TDGPPTLNSETSD S--------------------YNSTTHNITTDVDIIS--TASKR--NAALRNTRHGSWYI QVLVKTIA-------QHAHE-MDLL-----------EILTLVNSAIKSKEGH--STDFDS QGVKEMSEFHS-----TLCKKLFFYPGIVQTE------------ >H_sapiens_ENSP00000365051 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEA AWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMI-EDIQRAG SGSRRDQARQLIIDLETR------------------------------GSQALPLFISCL EDTGQDMLASFLRTN------RQAAKL--------------------------------- ----------SKP-------TL-----ENLTPVVL-------RPEIRKPEVLR----PET PRPVDIGSG--------------------------------------------------- -----------------GFGDVGALES----LRGNADLAYIL---SM-EPCGHCLIINNV NFC--R-------ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA QQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSVEKIV NIFNGTSCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------STSPEDESPGSNP E-PDATPFQE--GLRTF---DQLDAISSLPTPSDIFVSYSTFPG--FVSWRDPKSGSWYV ETLDDIFE-------QWAHS-EDLQ-----------SLLLRVSAAFLCK----------- GEGRLLRGSVSSWGWGFGVSRAGPNQG----------------- >P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------ ------------------MENTENSVDSKSIKN--------------------------- ------LEPKIIHGSQSM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ISLDNSYKM---DY-PEMGLCIIINNK NFH--K-------STGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVS KE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------GP-VDLKKIT NFFRGDRCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GV------D DDMA---------------------CHKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------QYADK-LEFM-----------HILTRVNRKVATEFES-FSFDATF HAKKQIPCIVS-----MLTKELYFYH------------------ >H_sapiens_ENSP00000311032 ------------------------------------------------------------ ------------------MENTENSVDSKSIKN--------------------------- ------LEPKIIHGSESM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ISLDNSYKM---DY-PEMGLCIIINNK NFH--K-------STGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVS KE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------GP-VDLKKIT NFFRGDRCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GV------D DDMA---------------------CHKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------QYADK-LEFM-----------HILTRVNRKVATEFES-FSFDATF HAKKQIPCIVS-----MLTKELYFYH------------------ >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ---------MEEADRQLLRRCRVRLVRELQVAE--LWDALLSRE-LFTRDMI-EDIQRAG SGSRRDQARQLVIDLETR------------------------------GRQALPRFISCL EDTGQGSLASFLQSS------GQAAKQDPE--AVTPLDHLVPVVLGPMGLKSKEQKV--- -----VKLDPSQP-------AL-----GNLTPVVLGPEE--LWPTRLRPEVLT----PET PRPVDIGSG--------------------------------------------------- -----------------RAHDVCTPGK----IERHADMAYTL---DS-DPCGHCLIINNV NFC--P-------SSGLSTRIGSHVDCEKLQHRFCWLRFMVEVKNDLTAKKMVTALMEMA HR-D--HRALDCFVVVILSHGCQASHLQFPGAVYGTD-------------GCSVSIERIV NIFNGTGCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------FTSSQDKAFDSDS E-PDAVPYQE--GPRTL---DQLDAVSSLPTPSDILVSYSTFPG--FVSWRDKKSGSWYI ETLDGVLE-------QWARS-EDLQ-----------SLLLRVANAVSEK----------- GVYKQIPGCFN-----FLRKKLFFKLH----------------- >E_caballus_ENSECAP00000019797 ------------------------------------------------------------ ------------------MENSKISVDSKSIKN--------------------------- ------SETKILHGSKSM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ISLDSSYKM---DY-PEMGLCIIINNK NFH--K-------STGMASRSGTDVDAANLRETFTNLKYEVRNKNDLTGEEIVALMRSVS KE-D--HSKRSSFICVLLSHGEE-------GIIFGTN-------------GP-IDLKKLT CFFKGDCCRSLAGKPKLFIIQACRG-----TEL-DSGI--E------TDS-GI------E DDMA---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------LYAHK-LELM-----------HILTRVNRKVAMEFES-YCLDPTF HGKKQIPCIVS-----MLTKELYFYH------------------ >P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------ ------------------MENTENSVDSKSIKN--------------------------- ------LEPKVIHGSKSM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ISLDNSYKM---DY-PEMGLCIIINNK NFH--K-------STGMASRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVA KE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------GP-VDLRKIT NFFRGDRCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GV------D DDMA---------------------CHKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------QYADK-LEFM-----------HILTRVNRKVATEFES-FSLDATF HAKKQIPCIVS-----MLTKELYFYH------------------ >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------------------------------ST-K-------------- --KKKTEDPEKPPQASDN------------------------------VRI--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------VTPAFQYKM---NY-GKVGRCIIINNK NFD--D-------ITGMSPRNGTDIDARDLLRCFKGLGFDVTVFNNKSCTEMETLLRSVA EQ-D--HKDSACFACIFLSHGEE-------GLIYGTD-------------GA-MPIKVLT TLFRGDKCRSLVGKPKLFFIQACRG-----CEF-DDGL--E------TDA-GP------S N-DSLET-------------DANP-RHKIPVEADFLYAYSTVPG--YYSWRNPGRGSWFV QALCNVLN-------EHGKE-LEVM-----------QILTRVNYLVATQFES-YCDDPQF NKKKQIPCVVS-----MLTKELYFKPC----------------- >C_familiaris_ENSCAFP00000032189 --------------------------------------------------MGEQRNTSSK ELAAAEATGQSGKELEVSMENTENSVDAKSFKN--------------------------- ------AETVIV---KIL------------------------------KDK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------YLTKLHYKM---DY-PEMGLCIIINNK NFH--K-------STGMAPRSGTDVDAANLRETFTNLKYEVRNKNDLTCEEILELMNSVS KE-D--HSKRSSFVCVLLSHGDE-------GIIFGTN-------------GP-VDLRKVT GFFRGDYCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GI------E DDMA---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------LYAHK-LEFM-----------HILTRVNRKVATEFES-FSLDSAF HGKKQIPCIVS-----MLTKELYLYH------------------ >M_mulatta_ENSMMUP00000037898 ------------------------------------------------------------ ------------------------------------------------------------ --------MRIPTKWFYL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------FFKRAPTYRM---DR-NHRGLCVIVNNH SFI--S----------LRDRRGTHKDAEILKGVFQWLGFTVHIYNNVTKGEMEEVLQKEK CNPA--HADGDCFVFCILTHGED-------GAVYSSD-------------EALIPIREIM SHFTALQCPGLAEKPKLFFIQACQG-----EKI-QLSKSIE------ADA-LN------P E-QAPTS-------------LQ----DSIPVEADFLLGLATVPG--YVSFRHVEEGSWYI QSLCNHL----------------------------------------------------- -------------------------------------------- >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ ---------MDEADRRLLWRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMI-EDIQRAG SGSRRDQARQLIIDLETR------------------------------GSQALPLFISCL EDTGQDMLASFLRTN------RQAAKL--------------------------------- ----------SKP-------TL-----ENLTPVVLRPEI--VRPEIRKPEVLR----PET PRPVDIGSG--------------------------------------------------- -----------------GFGDVGALES----MRGNADLAYIL---SM-DPCGHCLIINNV NFC--R-------ESGLRTRTGSNIDSEKLRRRFSSLHFMVEVKGDLTAKEMVLALLELA QQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSVEKIV NIFNGTSCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------STSPEDESPGSNP E-PDATPFQE--GLRTF---DQLDAISSLPTPSDIFVSYSTFPG--FVSWRDPKSGSWYV ETLDDIFE-------QWAHS-EDLQ-----------SLLLRVANAVSVK----------- GIYKQMPGCFN-----FLRKKLFFKTS----------------- >M_domestica_ENSMODP00000005560 ------------------------------------------------------------ ------------------MEDTGTTVDAKSIKN--------------------------- ------SGVKSLHSSKSV------------------------------ESG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LSSDSYKM---DY-PEMGLCVIINNT HFH--N-------DTELSPRTGSDKDAANLIDIFRSLKYEVRNKNNLTRDKMIELLRQVS EE-D--HSQRSSFVCVILSHGEE-------GVIFGTD-------------DS-VELKELT YFFKGYKCKSLTGKPKLFIIQACQG-----REF-DCGV--E------TDS-GT------D EDVA---------------------CHKIPVEADFLYAYSTVPG--YYSLRDPKDGSWFI QALCAVLK-------QHAHK-LEIM-----------QILTRVNRKVATEFES-YSSKASL HAKKQMPCIMS-----MLTKELYFSH------------------ >T_guttata_ENSTGUP00000006879 ------------------------------------------------------------ -----------MTDIGDGAHLGKDLADTKSIPG--------------------------- ------FKGKNLPASKSM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ILPDYSYRM---DY-PEMGECIIINNK NFH--R-------YTGMSPRSGTDADAASVREVFMKLGYKIKINNDLSCEGIFNLLKNVS EE-D--HSKRSSFVCVLLSHGDE-------GLIYGTD-------------GP-LELKALT SLFRGDRCRSLAGKPKFFFIQACRG-----TEL-DSGI--E------TDS-GS------E E-TM---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSAEGSWFI QSLCKMLK-------EHARK-LELM-----------QILTRVNRRVA-EYES-CSTRQDF NAKKQIPCIVS-----MLTKEFYFPS------------------ >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ ---------MEEAQRSALRRGRVRLVEGLRPEV--LWGPLQARG-VFTSAMV-EDMQS-- TGTRREQARQLVIDLETR------------------------------GKQAFPIFLSIL RDTGHGDLADMLDEG------CGSPMSPPV--DLRPVQLELPG--ERRDKSVSTAERLSI PVQPESERFRMPP----------------------------------------------- ------------------------------------------------------------ -----------------APAQACPTG-----LAGECSEVYQL---RA-DPCGHCLIFNNV SFS--R-------DSDLSTRAGSDIDCEKLEKRFRSLCFHVRTLRNLKAQEIDVELRKLA RL-D--HSALDCCLVVILSHGCQTSHIQFPGGIYGTD-------------GKIIPIERIV NYFNGSQCPSLRGKPKLFFIQACGG-----EQK-DQGFEVD------CESPQDETCRRSI E-SDAIPFQA--PSGNE---DEPDAVASLPTPGDILVSYSTFPG--FVSWRDKVSGSWYV ETLDSVLE-------HYARS-EDLL-----------TMLLRVSDIVSTK----------- GRYKQIPGCFN-----FLRKKFFFLCK----------------- >G_gallus_ENSGALP00000019870 ------------------------------------------------------------ -----------MSGAERRPAAGRVQLDSKPTPT--------------------------- --TTADGNQNITEVDAFD------------------------------KRQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TFDPAVQYKM---NH-QRRGVALIFNHE HFF--W-------HLRLPDRRGTLADRNNLKRSLTDLGFEVRIFDDLKAEDVLKKVFEAS RD-D--YSNADCFVCVFLSHGEN-------DHVYAYD-------------AQ-IKIETIT NMFRGDKCQSLVGKPKIFIIQACRG-----DKH-DDPV-LV------QDS-VDSKDE-TT V-NQTEV-------------DAAG-VYTLPAGADFIMCYSVAQG--YFSHRETVNGSWYI QDLCEALG-------KHGSS-LEFT-----------ELLTVVNRKVSHRKVD-ICRDINA IGKKQIPCFAS-----MLTKKLYFHPKSK--------------- >A_aegypti_AAEL003444-PA ------------------------------------------------------------ -------------------MDTTDELDVLGFGS--------------------------- ---RTNESSKSIKEALVS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------RAALDEYYDT---TN-KRRGIALVFCHM NFS------------VMAKRNGADKDRDDICNTLYGLDFDVRVFDDLSRKEVLDRLKDVS RE-D--HSDNDCLVVVMMSHGEQ-------GVLYARD-------------NK-YNVDSLW KNFVGNACPSLIGKPKMFFIQACRG-----EQF-DEGVAYA------AKSPK-------- --DMVDS-------------RQEQVLYSIPAMADLLVMYSTYDG--YYSWRNPRQGSWFI QSLCTELD-------ENGRV-RDLL-----------TLLTGVSRRTAYEFQSFVPHNAKM DAMKQIPCIVS-----MLTKTFYFTKKTRSRVVTDID------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ ---------MDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFKPHMI-EDIQRAG SGSRRDQARQLITDLETR------------------------------GSQALPSFISCL VDTGQDMLASFLRTN------RQAVKL--------------------------------- ----------SKP-------TL-----ENLTPVVL-------RPEIRKPEVLR----PET PRPVDIGSG--------------------------------------------------- -----------------GCGDVGAPES----LRGNADLAYVL---SM-EPCGHCLIINNV NFC--R-------ESGLSTRTGSSIDCEKLQRRFSLLHFMVEVKHDLTAKEMVLALLELA RR-D--HSALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCPVSVERIV NIFNGTSCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------STSPEDESSGSNP E-PDATPFQE--DLRTF---DQLDAVSSLPTPSDIFVSYSTFPG--FVSLRDPKSGSWYI ETLDNIFE-------QWAHS-EDLQ-----------SLLLRVADAVSVK----------- GIYKQMPGCFN-----FLRKKLFFKTS----------------- >P_troglodytes_ENSPTRP00000048878 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVP-KK--LEKSSSASD-VFEHLLA-EDLLSED DPFFLAELLYIIRQKKLL-QHLNYTKEEVERLL--PTRQRVSLF----RNLLYELSEGID SENL-KDMIFLLKDS------LPKTEM----TSLSFLAFLEKQGKIDEDNLTCLEDLCTT VVPKLLRNIEKYK-------RE-----KAVQIVTPPVDK--EAES-YQGEEELVSQT--D VKTFLEALPQ-ESWQNKHAGSNGNRAT--------NGAPSLVSRGMQGAS---------- --------------------ANTLNSE----TSTKRATVYRM---NR-NHRGLCVIVNNH SFT--S----------LKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEEVLQRQK CNPA--HADGDCFVFCILTHGRF-------GAVYSSD-------------EALIPIREIM SHFTALQCPRLAEKPKLFFIQACQG-----EEI-QPSVSIE------ADA-LN------P E-KAPTS-------------LQ----DSIPAEADFLLGLATVPG--YVSFRHVEEGSWYI QSLCNHLK-------KLVPRMLKFLEKTMEIRGRKRTVWGAKQTQISATSL-------PK AISAQTPRPPM-----HRWSSVS--------------------- >H_sapiens_ENSP00000286186 ------------------------------------------MKSQGQHWYSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCIGLVPNKK--LEKSSSASD-VFEHLLA-EDLLSEE DPFFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLF----RNLLYELSEGID SENL-KDMIFLLKDS------LPKTEM----TSLSFLAFLEKQGKIDEDNLTCLEDLCKT VVPKLLRNIEKYK-------RE-----KAIQIVTPPVDK--EAES-YQGEEELVSQT--D VKTFLEALPQ-ESWQNKHAGSNGNRAT--------NGAPSLVSRGMQGAS---------- --------------------ANTLNSE----TSTKRAAVYRM---NR-NHRGLCVIVNNH SFT--S----------LKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK CNPA--HADGDCFVFCILTHGRF-------GAVYSSD-------------EALIPIREIM SHFTALQCPRLAEKPKLFFIQACQG-----EEI-QPSVSIE------ADA-LN------P E-QAPTS-------------LQ----DSIPAEADFLLGLATVPG--YVSFRHVEEGSWYI QSLCNHLK-------KLVPRHEDIL-----------SILTAVNDDVSRRVD-------KQ GTKKQMPQPAF-----TLRKKLVFPVPLDALSL----------- >M_domestica_ENSMODP00000005556 ------------------------------------------------------------ ------------------MEDTGTTVDAKSTKN--------------------------- ------SGVKLFHGSKSV------------------------------ESG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LSSDSYKM---DY-PEMGLCIIINNK NFH--P-------NTGMSFRSGTDVDAASLSDTFRSLKYEVRIKNDLTCNEITELLNSVS KE-D--HSQRSSFICVILSHGEE-------GVIFGTD-------------RS-VELKRLT CFFRGDKCRSLTGKPKLFIIQACRG-----TEL-DCGV--E------TDS-GT------D EDIA---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QALCAVLK-------QHAHK-LEIM-----------QILTRVNRKVATEFES-YSLDISF HAKKQVPCIMS-----MLTKELYFSH------------------ >D_rerio_ENSDARP00000006831 ------------------------------------------------------------ --------------------MNGDCVDAKRVDT--------------------------T DASKDGASAS---QPMQV------------------------------DAK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PQSHAFRYSL---NY-PNIGHCIIINNK NFD--R-------RTGMNPRNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQIMQVLTTVA HD-D--HSRCASLVCVLLSHGDE-------GVFFGTD-------------TS-VDLKSLT SLFRGDRCPSLVGKPKLFFIQACRG-----TEL-DPGV--E------TDH-PD------H P-------------------DIPDGRVRIPVEADFLYAYSTVPG--YYSWRNTMTGSWFI QSLCEMMT-------KYGSE-LELL-----------QIMTRVNHKVALDFES-TSNMPGF DAKKQIPCIVS-----MLTKEMYFTP------------------ >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ ------------------------------------------------------------ ----------------FR------------------------------RNH--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LFDPAAEYKM---SH-KRRGLALIFNHE HFF--W-------HLMLPERRGTQADKENLKRGLTDLGFEVKCFDDLKAEEVLQNIYNVS TD-E--HDDADCFLCVFLSHGED-------DHVYAYD-------------AK-IEIKSLT NMFKGDKCPSLVGKPKIFVIQACRG-----DKH-DDPV-IA------RDT-VDSKKE-LD I-NETEV-------------DTAA-VYTLPAGADFLMCYSVAEG--YYSHRETINGSWYI QDLCEMLK-------RHGSS-LEFT-----------DLLTLVNRKVSHREVD-VCKDRKA LGKKQIPCFAS-----MLTKKLYFRPKFK--------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ ---------MEEIHKRILQRNRINLVRDLDPSS--LYDGLLEKG-VFTQDMI-DEIKS-- AGTRRDQARKLVQDLETR------------------------------GSRAFAMLLLCL EETDQHGLAELLQRA------APAVQIWPAAP---NQPFVLMLNS---------REKTTS PSIQYRNPVPVHL-------TH-----CD--------------AHVTAPER--------- ------------------------------------------------------------ -----------------ENTLTRPPGR----TRRDSIQSYKM---DA-SPCGHCLIINNV EFE--P-------DSELSNRKGSNIDCDKLEKRFKALNFIVEVRTNLKQRQIKHALSALS KK-D--HSQCDCCVVIMLSHGTEVSHNRFPGAVYGVD-------------GQHVPVQLIT NYLNGQHCPSLQGKPKLFFIQACGG-----GER-DTGFEVS------PDEVEPSIGGADD Q-TDAIPMSS--SSDSLSLSDEVDARATLPTPSDILVSYSTFPG--YVSWRDTQSGSWYV ETLDQVLE-------QNAAT-DDLV-----------TMLMMVNHEVSQNSAK-------- GLYKQMPGSFN-----FLRKLLHFQTHA---------------- >G_gallus_ENSGALP00000017288 ------------------------------------------------------------ ----------MMTDIKDGPRSGEDVSDARSFPG--------------------------- ------SKGMNLPASKSV------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ILPDDSYRM---DY-PEIGVCVIINNK NFH--R-------DTGLSSRSGTDADAASVREVFMKLGYKVKLNNDLSSRDIFKLLKNVS EE-D--HSKRSSFVCVLLSHGDE-------GLFYGTD-------------GP-LELKVLT SLFRGDKCRSLAGKPKLFFIQACRG-----TEL-DSGI--E------ADS-GP------D E-TV---------------------CQKIPVEADFLYAYSTAPG--YYSWRNAAEGSWFI QSLCRMLK-------EHARK-LELM-----------QILTRVNRRVA-EYES-CSTRQDF NAKKQIPCIVS-----MLTKEFYFPC------------------ >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ --------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAK-LITQRDY---NNLSD VSERETKIIKLLDKLIGR------------------------------GEETCQEFIDLL RQDCVLENFPVLEGH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AIFA----SSVQKVSQYKI---TQ-NPRGICVIINNV DFT------------SMGERRGSDEDQNYLAKVFRWLGFEVVAHRNKTAAEMKNILQALG RTVD-----GDCFVCCVLSHGVE-------EGVCGTD-------------GSLVSVDEIR NPFTGVNCQKLVGKPKLFFIQACRG-----QRK-QLRVNAQ------ADGPGDGE----- --SEMEV-------------DGDDFDITIPSDTDFLIARSTTDG--HVSYRKPDEGSWFI QSLCRNLE-------KHCPLGADIL-----------TILLSVNNEVSIQGLH-------- --SKQMPVHEV-----AMRMKLILPPVNN--------------- >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ---------MDEADRQLLRRCRVRLVSELQVAE--LWDALLSRE-LFTRDMI-EDIQQAG SGSRRDQARQLVTDLETR------------------------------GRQALPLFISCL EDTGQGTLASLLQSG------RQAAKQDPE--AVKPLDHLVPVVLGPMGLTAKEQRV--- -----VKLDPSQP-------AV-----GNLTPVVLGPEE--LWPARLKPEVLR----PET PRPVDIGSG--------------------------------------------------- -----------------GAHDVCVPGK----IRGHADMAYTL---DS-DPCGHCLIINNV NFC--P-------SSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMA HR-N--HRALDCFVVVILSHGCQASHLQFPGAVYGTD-------------GCSVSIEKIV NIFNGSGCPSLGGKPKLFFIQACGG-----EQK-DHGFEVA------CTSSQGRTLDSDS E-PDAVPYQE--GPRPL---DQLDAVSSLPTPSDILVSYSTFPG--FVSWRDKKSGSWYI ETLDGILE-------QWARS-EDLQ-----------SLLLRVANAVSAK----------- GTYKQIPGCFN-----FLRKKLFFKTS----------------- >R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------ ------------------MDNNETSVDSKSINN--------------------------- ------FETKTIHGSKSM------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------IYLDSSYKM---DY-PEMGLCIIINNK NFH--K-------STGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDSVS KE-D--HSKRSSFVCVILSHGDE-------GVIFGTN-------------GP-VDLKKLT SFFRGDYCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GT------D DDMA---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSRDGSWFI QSLCAMLK-------LYAHK-LEFM-----------HILTRVNRKVATEFES-FSLDATF HAKKQIPCIVS-----MLTKELYFYH------------------ >T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------ ----------------------------------------SAYQ-LFLSLCD-QDHLSEE RPHLLSELLSIIQRTRLL-RDLDLRSS--------ATSNLISAY----RKLLYSLSEDLT DDNL-KEIKFLLTET------LPRRKLEDNVTTLEVFLELECMDLLSKTNLGLLKSILQP VCPVLAERIRQFE-------AQ-----N---------------------SCQPAADWGFA VKKITDPLQVQ--------GGSDALPS----LPEENQSSSRTEASVMSSANAVGIK---- -------PGTLMLGL--SPPPVGSP-N----FPVQDLGTYPM---TT-LPRGCCLIISNY DF---Q-------GSGLGMRNGTRTDEECLKKVFEWLGFKVEIHRDCTGKEILSLMQELA DK-S--QQRWDCLVCCILSHGLE-------GCVHGVD-------------GDQVSIKKLI EPFLGTNCPAMAGKPKLFFIQACQG-----KKQ-QGVVHLE------SDG--A------E H-SDVDT-------------DAVRLSNCIPSHADFLLGMATVPD--YVSYRDRERGTWYI QSLCEYLV-------KMVPRGFDLM-----------SILTKVNEDVSKKND-------NT GDRKQMPQPVF-----TITKRIVFPVPSGPAPVLPHFPFVEDSP >T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNM DFQARLLKVGNDLRKDEVRALVFLCSDILG-CN--PAAVQSAGD-LFSRLSD-QDHLSEE QPHLLVELLGIIQRTKLL-RDHNLPRT--------GAQDLISPYSCKSRKLLYSLSEELT ADDL-KDIKFLLNNK------LPRGKLEE-VTTLEVFMELEHRALISDTDLGFLESIIQP VCPVLLEKINQFN-------AQ-----NCKMHLILHIFD--SYLNQIQLNTQLKALW--L IKKF-DSFLVSFSSNESWIGGSGNRPT--------NRCPLLTAASLLEQS---------- ------------CSF--NTLQVGCP-D----VSVQGVETYLM---TA-AKRGRCLIINNC NF---R-------VSRLKKREGTMVDEASLDKVLKWLGFEVEIQRDCTSKKMSSLIQELA KT-S--QRDWDCVMCCVLSHGLE-------GGVYGVD-------------GGTVEIRKLM EPFSGTNCPSLAGKPKIFFIQACQG-----SRQ-QDIVYTD------AGT--P------G H-GYVDN-------------NAVQAKECIPSHADFLLGMATVPS--FVSFRDGTHGTWYI QSLCQNLA-------DMVPRGCDLI-----------SILTKVNADVSKKVAW-----IDS GHKTQMPQPAF-----TLTKKIVFPAPNTPHPV----------- >D_melanogaster_FBpp0084848 -----------------------------------------------------MDATNNG ESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSHPY---------------G SGAIGQLANGYSSPSSSY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RKNVAKM----VTDRHAAEYNM---RH-KNRGMALIFNHE HFE----------VPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAA SQ-N--HSDSDCILVAILSHGEM-------GYIYAKD-------------TQ-YKLDNIW SFFTANHCPSLAGKPKLFFIQACQG-----DRL-DGGVTMQ------RSQ---------- --TETDG-------------DSSM-SYKIPVHADFLIAYSTVPG--FYSWRNTTRGSWFM QSLCAELA-------ANGKR-LDIL-----------TLLTFVCQRVAVDFESCTPDTPEM HQQKQIPCITT-----MLTRILRFSDKQLAPAGRV--------- >T_guttata_ENSTGUP00000004278 ------------------------------------------------------------ -----------MSGSERRPPAGHVQLDSRPTL---------------------------- --PTTDGNENITEVDALN------------------------------IRQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SLDPAEEYKM---NH-QRRGLALIFNHE RFY--W-------HLRLQDRRGTWVDRNNLKSILTELGFEVRLFDDLKKEDVQQRIYEAS TA-D--HSNADCFVCVFLSHGED-------GHIFAYD-------------DK-IEIQTIT DMFRGDKCQSLVGKPKIFIIQACRG-----DKH-DDAV-IA------HDS-ADGSE--SP G-NETDV-------------DAAG-VYTLPAGADFIMCYSVAQG--YYSHRDTINGSWYI QDLCETLR-------KHGSS-LEFA-----------ELLTVVNRKVSCRRVG-MCKDINA IGKKQIPCFAS-----MLTKKLYFHPKSK--------------- >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ ---------MEESQRELFQKNRLRLVCELQVEP--LWDLMLDRE-LFTRDMI-EDIQR-- AGTRRDQARQLVTDLQTR------------------------------GKRALPIFISCL EATGQWDLAALLSES------NTTLTQQPDPIDIKPVEMIRSGGLRSTGRYTSMVSL--- ----HLLLLANSP-------FL-----YFIDAVLVSAHN--LFPLELIKRQ------PTF SKVLSLLYK--------------------------------------------------- -----------------LRFPFCPPPQ--------VGQVYTL---NS-DPCGYCLIINNV DFC--A-------SSGLSSRKGSNIDCEKMHNRFQALHFAVEVERNLSAKGMGAALQQLA ER-D--HSALDCCVVVILSHGCQASHIQFPGAIHGTD-------------GASISVERIV NIFSGSRCPSLGGKPKLFFIQACGG-----DQR-DHGFQVS------SNIPEDKSPGSDP E-TDATPFQN-----NF---DQPDAVASLPTPSDILVSYSTFPG--FVSWRDPKSGSWYI ETLDRVLE-------EWADR-EDLL-----------HMLLMVSNAVSAR----------- GTYKQIPGCFN-----FLRKRFFFKTK----------------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ECYDT---SN-ARRGIALIINQV IFS------------SMAVRVGSSKDRTDISTVLQRIGFEVRVMDDPNRKQLLSALKQLA GE-D--HSHSDCLVVVVMTHGKE------NNLLYASD-------------KS-YEANQLW EPFIGDACPSLIGKPKLFFVQACRG-----KKL-DEGVIQATIS---IDS---------- --VDTQS-------------SPGSMRYVIPAMADLLVMYSTYDG--HYSWRNPSKGSWFI QSLCAELG-------ASAHC-KELL-----------HILTAVSRRVAYHYQSNVPDNAKI DAKKQMPCMVS-----MLTKLLYLRPKK---------------- >M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------ ------------------MENTENSVDSKSIKS--------------------------- ------LEPKIIHGSKSV------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ISLENSYKM---DY-PEMGLCIIINNK NFH--K-------STGMASRSGTDVDAANLRETFINLKYEVRNKNDLTREEIVELMRNVS KE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------GP-LDLKKIT SFFRGDCCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GV------E DDMA---------------------CHKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCAMLK-------QYADK-LEFM-----------HILTRVNRKVATEFES-FSLDATF HAKKQIPCIVS-----MLTKELYFYH------------------ >C_intestinalis_ENSCINP00000003204 ------------------------------------------MS---------------- -----------------LKSAADVLMSGVPTPH--------------------------- --TNENNNVGQSEVDALG------------------------------SGETPRIYSLPD VTKM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ASSEVECYQM---DR-ESRGLALIINNE NFH--H-------ATRMNKRSGTDVDARNLSRIFKKLGFDVQVYKDLSCISMLEVINEVS TM-D--HTGNDCCFVAFLSHGDD-------GCVYGTD-------------GI-VQIKKIV DQFRGDVCPSLAGKPKIFLFQACRG-----TLH-ETSVQLS------VDV-VDGE----D Q-PCVEV-------------DAAP-VPTLPSGSDYLFCYSVAEG--YYSHRDTLYGSWFI QDFTDVMEQLVLNKGKQQDK-VDFI-----------DVLTVVNRKVSARRVE-RSYSQQA LGKKQMPCYLS-----MLTKKLYLTPKK---------------- >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DKYRYKM---DY-PCMGTCVIINNK TFD--P-------KTGLSPRNGTDVDAAELEKTFSRLGYKVTVANDQTADQMVDLLADVS KQ-D--HRKSASFVCALLSHGDE-------DGIYGTD-------------G--TSLDDLT KFFKGDRCRSLVGKPKLFFIQACRG-----TDT-DRGVNFD------ADS-TD------G Q-----------------------MLQSIPLEADFLYAYSTPSG--YYSWRNTQNGSCFM QSLCEILH-------SFS-Q-LELM-----------QIMTRVNYEVALHFES-SSDKLGY SGKKQIPCIMS-----MLTKDFYFPK------------------ >O_anatinus_ENSOANP00000000517 ------------------------------------------------------------ ------------------AASGEVMVDSKSFHS--------------------------- ---SQGYSSRKVPGKQFL------------------------------GSS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ASLDDRYRM---DY-PNMGICLIINNK NFH--P-------DTRMGCRSGTDVDAASLRDTFKKLKYEVRCKNDLKRREILELLTSVA HE-D--HSKRSSFVCVLLSHGEE-------GVIFGTD-------------GS-LELKSLA SLFRGDNCRSLVGKPKLFIVQACRG-----TEL-DSGV--E------ADS-SS------A DDGS---------------------EQKIPVEADFLYAYSTAPG--YYSWRNSMNGSWFI QALCAMLK-------QHAHT-LELL-----------HILTRVNRKVATEFES-YSLDATF NAKKQIPCIVS-----MLTKELYFPY------------------ >G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------M HFQKLLFDIGKALSGEEVKALAFLCTDILG-RN--LSSVESASG-LFSRLRD-QGFLSAE QPHLLTELLIIIQRVRLT-RDVDLPAE--------PSS-LISPY----RKMLYNLSEELT ADDL-KDMKFLLHSY------LPRRKLEENVSTLEIWLEMEHKDLMNEHNLHLLEILISK VCPMLKDKINQLK-------AQ-----Q-------------------ETPTSPATQESGR QGSLSAPNAPN--------QVPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLK IEVVETMPPPKNMSC--SEPPTSQPSD----TNTEVLGTYPM---TS-AKRGICLIVNNF DFT--K-------FKNYQNREGTMKDEERLHKVFAWLGFEVEVKHDCEGEQMLTALRELA SR-N--HGQADCLVCCVLSHGDE-------GCVYGVD-------------GHTVAIKELK EPFNGLNCASLAGKPKLFFIQACQG-----TGE-QKAVNVV------PDG--P------E D-SAVCS-------------DAFKASDAIPSEADFLLGMSTVPS--FVSYRHRKNGSWFI ESLCQNLV-------QMVPKL--------------------------------------- -------------------------------------------- >P_pygmaeus_ENSPPYP00000014602 ------------------------------------------MKSQGQHWCSSSDKNCKV SFREKLLIIDSNLGVQDVENLKFLCVGLVPNKK--LEKSSSASD-VFEHLLA-EDLLSEE DPFFLAELLYIIRQKKLL-QHLSYTKEEVEGLL--PTRQRVSLF----RNLLYELSEGID SENL-KDMIFLLKDS------LPKTEM----TSLSFPAFLEKQGKIDEDNLTCLEDL-KT VVPKLLRNIEKYK-------RE-----KAVQIVTPPIDK--EAES-YQGEEELVSQT--D VKTFLEALPQEESWQNKHAGSNGNRAT--------NGAPSLVSRGMQGAS---------- --------------------ANTLNSE----TGTKGRKGYRM---NR-NHRGLC-LLNNH SFT--S----------LKDRRGTHKDAEILSHVFQWLGFTVHIHNNVTKGEMEEVLQEQK CNPA--HADGDCFVFCILTHGKF-------GAVYSSD-------------EALIPIREIM SHFTALQCPRLAEKPKLFFIQACQG-----EEI-QPSVSIE------ADA-LN------P E-QPPTS-------------LQ----DSIPAEADFLLGLATVPG--YVSFRHVEEGSWYI QSLCNHLK-------KLVPRHEDIL-----------SILTAVNDDVSRRVD-------KQ GTKKQMPQPAF-----TLRKKLVFPVPLDALSL----------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ ---------MEERHKKILQRNRINLVSELEPLN--LYDGLIEKG-VFTHDMI-DEIKC-- SGARRDQARQLVRDLETR------------------------------GSRAFPAFLECL KETGYHSLAELLQNG------APTVQIQPPTPIPVDRPVIQPLPISPPLV---------- --------PP-------------------EEPVSPVPKP--STPGRASPEV--------- ------------------------------------------------------------ -----------------EYVTLK--GR----IRRDSLQSYRM---EA-NPLGHCLIINNV EFE--P-------KSGLSNRNGSNVDCDRLERRFKALNFTVKVKTNLKQRQIRQELSALS KV-D--HSQYDCCVVVILSHGTEVSHSRFPGAVYGVD-------------GQFVPVQHIA TYLNGQYCPSLQGKPKLFFIQACGG-----DEK-DTGFQVS------PDEFEPPVVGADD Q-TDAIPVSS--SSDSLSMSDEPDARASLPTSSDILVSYSTFPG--YVSWRDPKAGSWYV ETLDRVLE-------ENAAL-HDLV-----------VMLTMVNDEVSQNQAK-------- GLYKQMPGSFN-----FLRKRLYFIAQP---------------- >X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------ ---------MASAKQQSSPSAGQIEKDSSSAS---------------------------- --QNKEQKANVAETDGWT------------------------------SRT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LELDPSAEYKM---TH-KRRGLALIFNHE DFY--W-------QLRLGSRRGTNTDSMNLNRILTDLGFDVQNYYNLRTLDILEKIQEAS TA-D--HSNADCFLCVFLSHGED-------RHIYSYD-------------SL-IDIQELT NSFKGDKCESLVGKPKIFIFQACRG-----EKH-DNPV-LP------TDE-TDSV---TL T-NITEV-------------DAAS-LYTLPAGADFIMCYSVAEG--YYSHRETVNGSWYI QDLCEVLK-------AHAAS-LEFT-----------EILTLVNRKVSQRSVA-FCNDPKA IGKKQIPCFSS-----MLTKKLFLKPKSN--------------- >A_gambiae_AGAP000830-PA --------------------------------------------------MSMPDVVDIR NEINKEHVRESLDRNGDEQQLVQDVNDALGTRK--------------------------- ---------GHDPTNHLV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RARM----PVERYACDYNM---NH-KRRGLALIFNHE NFD----------VPQLRSRAGTNVDCENLTASLKGLDFEVHVFKDLKLRDLQKEVERVS QM-D--HSDADCLLVTILSHGEL-------GYLYAKD-------------CQ-YKLDTIW TYFTANHCPSLAGKPKLFFIQACQG-----DQL-DGGVVLEA-----KDR---------- --TETDS-------------SSSMLTFKIPMYADFMIAYSTIPG--FYSWRNTQKGSWFI QSLCHELN-------QNGRK-YDLM-----------VLLTFVTQRVAYDFESNTPDIPMM HQQKQIPCTTS-----MLTRLVYFNQKK---------------- >T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------ -------------MSANGPASGEDFTDASKGGE--------------------------- --QPSGSSSS---GKMTV------------------------------DAK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SARYSFRYSL---DF-PNLGHCIIINNK NFD--R-------RTGMNTRNGTDVDAANAMKVFSNLGYRVRVHNDQTVAQISQLLTSAA KE-D--HSRCASFVCILLSHGDE-------GVLYGTD-------------GP-MEIKSLT SLFRGDRCRSLVGKPKLFFIQACRG-----NDL-DGGI--E------TDS-IE------D N-----------------------STTKIPVEADFLYAFSTAPG--YYSWRNTMSGSWFM QSLCDTIS-------KYGKE-LELQ-----------HILTRVNHKVAVEFES-DSSLPGF NAKKQIPCIVS-----MLTKEMYFS------------------- >O_latipes_ENSORLP00000010095 ------------------------------------------------------------ ---------------MASNRPGEDSTDARKDNG--------------------------- ---ELAAGASPAPDRMDV------------------------------DGK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PSSHSFRYSL---NF-PTIGLCIIINNK NFD--R-------GTGMNQRNGTDIDAASAMKVFSKLGYRVKIYNDQTVKQIKQLLTDVS RM-D--HSDSASFVCILLSHGDE-------GVFFGTD-------------GS-IELKTLT SLFRGDHCKSLVGKPKLFFIQACRG-----TEL-DDGI--E------ADS-KE------D -------------------------TTKIPVEADFLYAFSTAPG--YYSWRNTMTGSWFI NSLCEMLS-------KYGKE-LELL-----------HIMTRVNHMVAVEFES-ISTLPGF HAKKQIPCIVS-----MLTKEMYFYP------------------ >P_pygmaeus_ENSPPYP00000016744 ------------------------------------------------------------ -----------MSSVSGLRRG--------------------------------------- --HPAGGEENMTETDAFY------------------------------KRE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MFDPAEKYKM---DH-RRRGIALIFNHE RFF--W-------HLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVS TV-S--HADADCFVCVFLSHGEG-------NHIYAYD-------------AK-IEIQTLT GLFKGDKCHSLVGKPKIFIIQACRG-----NQH-DVPV-IP------LDV-VDNQTDKLD T-NITEV-------------DAAS-VYTLPAGADFLMCYSVAEG--YYSHRETVNGSWYI QDLCEMLG-------KYGSS-LEFT-----------ELLTLVNRKVSQRRVD-FCKDPSA IGKKQVPCFAS-----MLTKKLHFFPKSN--------------- >M_musculus_ENSMUSP00000091238 ------------------------------------------------------------ ------------------MENNKTSVDSKSINN--------------------------- ------FEVKTIHGSKSV------------------------------DSG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------IYLDSSYKM---DY-PEMGICIIINNK NFH--K-------STGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILELMDSVS KE-D--HSKRSSFVCVILSHGDE-------GVIYGTN-------------GP-VELKKLT SFFRGDYCRSLTGKPKLFIIQACRG-----TEL-DCGI--E------TDS-GT------D EEMA---------------------CQKIPVEADFLYAYSTAPG--YYSWRNSKDGSWFI QSLCSMLK-------LYAHK-LEFM-----------HILTRVNRKVATEFES-FSLDSTF HAKKQIPCIVS-----MLTKELYFYH------------------ >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ ---------MEEKHKRILRRNRVHLVKELDLSD--LCDVLLRKD-VFTQSMI-NDIKRQN CETKRDQARKLVKDLETR------------------------------GNEAFSAFLEGL RVTGQQNLLELLQKS------APRVHFQPGKSTEAGYLLIQPHPVYIEDAVPKKPRTQPS PRKRERRGGGVKV-------PHNIFIDKVKSDIFDSKSR--FRNNDNTNVC--------- ------------------------------------------------------------ -----------------THLTRCSRGQ----RSDHDGTASRM---DA-RPCGLCLIINNV EFE--P-------KTELSIRKGSNVDCDKLEKRFKSLNFVVEVRTNLKQRQIKSELSALS RK-D--HSIYDCCVVVILSHGTEVSHNRFPGAVYGVD-------------GNHVSVQEIT NYLNGQNCPSLQSKPKIFFIQACGG-----GEK-DIGFEVS------PDEAKPSIGGDGD Q-TDAIPFSS--SSESLSTSDETDAIPTLPTPSDILVSYSTFPG--YVSWRATVSGSWYV EVLDNILE-------EHAAT-LDLT-----------TMLTLVNDKVSQNSAK-------- GLYKQMPGSFN-----FLRKHVYFQTS----------------- >P_troglodytes_ENSPTRP00000028104 ------------------------------------------------------------ -----------MSSASGLRRG--------------------------------------- --HPAGGEENMTETDAFY------------------------------KRE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MFDPAEKYKM---DH-RRRGIALIFNHE RFF--W-------HLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEAS TV-S--HADADCFVCVFLSHGEG-------NHIYAYD-------------AK-IEIQTLT GLFKGDKCHSLVGKPKIFIIQACRG-----NQH-DVPV-IP------LDV-VDNQTEKLD T-NITEV-------------DAAS-VYTLPAGADFLMCYSVAEG--YYSHRETVNGSWYI QDLCEMLG-------KYGSS-LEFT-----------ELLTLVNRKVSQRRVD-FCKDPSA IGKKQVPCFAS-----MLTKKLHFFPKSN--------------- >E_caballus_ENSECAP00000010379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QEAYDM---SG-ARLALTLCVT-- -----------------KAREGSEADLDALERMFQQLGFESTTKRDPTAQQFQEELEKFQ QAMDAREDLVSCAFVVLMAHGVE-------GRLKGED-------------EQMVELESLF EVLNNKNCQALKARPKVYIVQACRG-----EQR-DPGETVG------SDDIMM------- --------------------IAKDSPETIPTYTDTLHIYSTVEG--YIAYRHDKEGSCFI QTLVDVFT-------ERR---GPIL-----------ELLTEVTRRMAEAELV-----QEG RTRKVNPEIQS-----TLRKRLYLQ------------------- >G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------ ---------------MSVNGPGEDRTDAKTEQS--------------------------- ---EVSSSAS---APEEV------------------------------DAK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PNVHSFRYSL---SF-PSIGQCIIINNK NFD--R-------GTGMNQRNGTDVDAANAMKVFGNLGYKVKVYNDQSVAQIQHVLTSVS KQ-D--HSCSASFVCVLLSHGDG-------DLFFGTD-------------GP-VPLKSLT SLYRGDRCKSLVGKPKLFFIQACRG-----TEL-DPGI--E------ADS-VK------D E------------------------TTRIPVEADFLYAFSTAPG--YYSWRNTTTGSWFM QSLCDMIS-------KYGKE-LELQ-----------HIMVRVNHKVAVAFES-VSNSPDF NARKQIPCVVS-----MLTKEMYFSP------------------ >T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------ --------VFLPKDMEAVRRNKTAIGTIFCADYGLILNKVDEKK-LITRRDY-NNLKNIN GEDIWGHVIALVDKIMNK------------------------------GDATCEAFLNLL QTDDDIKSTYPELKD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------THFNIFF----FFYLQDEQYEL---LS-QPTGLCVIINNE NFL------------DMKQRSGTNKDAQSLAEVFTWLGFRVLMCKDQTKEKMDRALNCFA SLVD--PKHGDAFICCILSHGEK-------SAVLGID-------------GEPLCIKQII RTFKATRQSALVSKPKMFLIQACQG-----KGT-HRGVLL-------KDLQTD------- ----------------------DCHTLSIPEEADILVATATVED--YVSFRHKIDGSWFI QSLCQELK-------EGCLRGEDMT-----------TILHRVNSEVSQKEAF-----IHP GEQKQMPEVRF-----TLRKRLVLSPHTA--------------- >M_domestica_ENSMODP00000036251 ------------------------------------------M-----------EDNSKI KFNQQLLSINEKLEPEEIEALKFLCSDLISPRN--LEDIESGHQ-LFQKFMD-EDLLNEG DYFLVAELLFLIKHHNLL-QKIGYTKEKVKKEL--SSKRKISSY----RVMLYNLSEEIT TEDF-EHIKFIMKEH------IPKTLK----TFLSLLRHMEKQNLLSENNLEILVNICKP LSINLIKRIEQYK-------SE-----KG-----ELPEF--ELIP-YHGCGVISEQV--S LMTFLSLLPL-FSWSRKHLPFSQQNEA--------NNSLEEVTGLWAQGA---------- --------------------EGGTLFS----DMTNEAKFYRM---DH-SHRGHCIIFNNF EFQ--T----------MKRRRGSCKDADELKSVFEWLGFTVKIHPNTEKREMEDILQQCS TSPE--HRESDCFVCCVLTHGES-------GSVFSSD-------------EEKIAIRELT SYFKAHRCPGLANKPKLFFFQACQG-----PDI-QESMLLE------EDAKIS------P P-IQVET-------------PQ----RYIPVEADFLLGMATVDG--CCAIRHTIKGSWYI QALCHRLK-------CMVPRNEDIL-----------TILTEVNNDVSQLTD-------AE GKKKQMPQPAF-----TLRKKVVFPVP--PLSP----------- >G_gallus_ENSGALP00000013591 -----------------------------------------------------------M EFSQLLFVISEALDRTELASLKFLSLEHVTVRK--REDIEEPKA-FFQALQE-KGMIEVG DLFFLKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPF----RYLLFQLSENIT KDDM-KCFKFLLGKE------LPKCKLSPETTMPDVFIEMEKKGILKEDNLTVLKTICGK VDKSLLKKIEDYELNLLGEGEMLVTEGQRSSTGAPEDSA--IWLAS-------------- ------------------------------------------------------------ -----------------SVAPDSLGNC----DQSSQLEVYKM---TS-RPRGVCLILNNH NFA--KAREAVPELRRMKDRNGTHVDADALRKVFSNLHFTVAEYKDCTAEEIRNIVNNYR CM-D--HNNKDCFVCCILSHGKK-------GIIYGVD-------------GQEVPIQELT TSFTGQNCQSLAGKPKVFFVQACQG-----DAY-QKGVTIE------TDS-GE------Q D-YSLET-------------DARFQLDCIPSEADFLLGMATLQD--YVSYRSPSQGTWYI QSLCQHLE-------SSCPRGEDIL-----------TILTAVNQEVSSKID-------KQ NAGKQMPQPSF-----TLRKKLIFPVN----------------- >A_gambiae_AGAP004920-PA ------------------------------------------------------------ ------------VCGRDILHCKTMNTSTLSTAF--------------------------- --DEVDNNTRVLSLVASV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PEIISSSVIHE----LEPVDDAHYNM---SH-NRRGVAAVFNHR KFL------------HASERKGTDADCDNIRQVLIYLQFEVRVYDDLTRKEIKQVLDDLA EE-D--HKNSDCLLVVIMTHGDD-------DVLHAKD-------------GT-FNVDRLW ENFIGDSCPSLLGKPKLFFIQACRG-----SSF-DTGVHFSQCMTQVAKTVVPYAMRELP QPSIVPGC------------PKSSIQYAIPSMADLLVMYSTYKG--HYSWRNPSTGSWFI RALCDELR-------EHGNS-KELL-----------QLLTSVSRRVAYEFQSNVPNNSQI DCQKQMPCIVS-----MLTRRIYFSKK----------------- >H_sapiens_ENSP00000265164 ------------------------------------------------------------ -----------MSSASGLRRG--------------------------------------- --HPAGGEENMTETDAFY------------------------------KRE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MFDPAEKYKM---DH-RRRGIALIFNHE RFF--W-------HLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVS TV-S--HADADCFVCVFLSHGEG-------NHIYAYD-------------AK-IEIQTLT GLFKGDKCHSLVGKPKIFIIQACRG-----NQH-DVPV-IP------LDV-VDNQTEKLD T-NITEV-------------DAAS-VYTLPAGADFLMCYSVAEG--YYSHRETVNGSWYI QDLCEMLG-------KYGSS-LEFT-----------ELLTLVNRKVSQRRVD-FCKDPSA IGKKQVPCFAS-----MLTKKLHFFPKSN--------------- >C_familiaris_ENSCAFP00000016791 ------------------------------------------------------------ -----------SSATCGLRRA--------------------------------------- --YRTADEQNVTETDAFY------------------------------KRE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MFDPEEKYKM---DH-KRRGIALIFNHE RFF--W-------HLTLPDRRGTSADRDNLVRRFSELGFEVKCFNDLKAEELLLKIHEAS TS-S--HIDADCFLCVFLSHGEG-------NHIYAYD-------------AK-IEIQTLT GLFKGDKCQSLVGKPKIFIIQACRG-----DQH-DVPV-LP------LDV-VDHRTDKLE D-NVTEV-------------DAAS-VYTLPAGADFLMCYSVAEG--YYSHRETVNGSWYI QDLCEMLG-------KFGSS-LEFT-----------ELLTLVNRKVSQRRVD-FCKDPNA IGKKQVPCFAS-----MLTKKLHFFPKSK--------------- >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MSPRNGTDVDAADAFRTFSKLGYKVTVANDQTVDQMIQLLVKVS KQ-D--HSNSASFVCVLLSHGDE-------GVIYGTD-------------GF-EKLDDLT KFFKGDRCRSLVGKPKLFFIQACRG-----TEL-DEGSQIE------ADS-VG------G Q-----------------------TSDRIPVEADFLYAYSTAPG--YYAWRNTQNGSWFM QSLCEMLR-------RFSGQ-LELM-----------QIMTRLNHRVALHFES-SSDTPGY SGKKQIPCIVS-----MLTKDFYFPK------------------ >T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------ -MAGEAAGIPELGGEAEGEHRCEDDVDAKPDRR--GRFLLFKSK-K-------------- --KNDGQMREQDYCSESH------------------------------YRI--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------VSPTFQYRM---SH-QRVGKCIIINNK NFD--E-------KTGMNVRNGTDRDAGELYKCFKSLGFDVFIYNDQTCEKMEHLLREAS EE-D--HSDSSCFACILLSHGEE-------GMIYGTD-------------GA-MPIKTMT SMFRGDMCKSLVGKPKLFFIQACRG-----SEF-DDGI--Q------TDS-GP------P N-DTMET-------------DANP-RHKIPVEADFLFAYSTVPG--YYSWRNPGRGSWFV QALCNVLN-------EFGKQ-LEIM-----------QILTRVNYMVATSFES-WSEDPRF SEKKQIPCVVS-----MLTKELYFKPC----------------- >C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MVDSEIRQ----AQLLAQEAYDM---SG-ARLALTLCVT-- -----------------KAREGSEADLDALERMFQQLGFESTMKRDPTAQQFQEELDKFQ QAMDARDDFISCAFVVLMAHGLE-------GRLKGED-------------GEMVELEDLF KVLNNKNCRALRAKPKVYIVQACRG-----EQR-DPGETVS------GDDIVM------- --------------------ITKDNPQTIPTYTDILHVYSTVEG--YIAYRHDKEGSCFI QTLVDVFT-------ERK---GPIL-----------ELLTEVTRRMAEAELV-----QEG KPRKVNPEIQS-----TLRKRLYLQ------------------- >T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------ -----------TNMSANGPSPGGDFTDAKKGAG--------------------------Q --QPRSGSSS---GRVTV------------------------------DAK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PAAYSFRYSL---DF-PNMGHCIIINNK NFD--R-------RTGMNTRNGTDVDAANAMKVFLSLGYKVKVHNDQTVNQMKQLLVSAA EE-D--HSACASFVCVLLSHGDE-------GVFFGTD-------------GS-VELKYLT SLFRGDRCKSLVGKPKLFFIQACRG-----NDL-DGGI--E------TDS-AA------D S-----------------------STTKIPVEADFLYAFSTAPG--YYSWRNTTSGSWFM QSLCDAIS-------KYGKE-LELQ-----------HILTRVNHKVAVDFES-VSNLPGF DAKKQIPCIVS-----MLTKEMYFS------------------- >T_guttata_ENSTGUP00000010625 ------------------------------------------------------------ DFRKLLFEVSEALVTEELSALKFLSLDHVPRRK--LEAIHEPKA-FFEVLQE-KDMIGAG NLFFLKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAY----RQLLYGIAEDLT SEDV-RSVKFLLQKQ------LPKNKLQENASMLQVFLEMEIKGIIKEDNMTTLKDILQR FRADIKKKIDAYE-------EK-----KKGLTGSAEVSL--ELPVSWIDSVDHIKQS--- ------------------------------------------------------------ -----------------TLGLPGEDRS----LSFQLLEAYKM---TS-RPCGVCLILNNH NFA--KAREGVLEHKHMKDRNGTDVDAAALRNVFSKLHFRVEEYRDLTAEEIRETVNIFQ SA-D--HEDKDCFVCCILSHGKK-------GIIYGVD-------------GQEVPIRELT TSFTAQNCSSLAGKPKVFFIQACQG-----DAF-HKGVAIE------TDS-VE------E D-SSLER-------------DARFQLDCIPAEADFLLGMATLQD--YVSYRSPKEGTWYI QALCQHLE-------YSCPRGEDVL-----------TILTAVNQEVSKKTC-------ER DAKKQMPQPSF-----TLRKRLIFPVN----------------- >G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------ -----------MSDTTGDGRGGRVASPNKAAT---------------------------- --DRAACTENLTETDALI-------------------------------RS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SLDPAEEYKM---DN-KRRGLALIFNQE RFF--W-------RLGLNDRHGTNADRYNLERRLSNLNFDVRAYDNLKQEEVLNKINEAA EE-N--HSDSDCFLLVFLSHGEN-------DQVYTYD-------------GK-ISVQDIT SLFKGDKCKSLVGKPKIFILQACRG-----DKH-DDPV-TA------CDA-VDSE---LK T-NEVVV-------------DASV-LHTLPAGADFIMCYSVAEG--YYSHRETINGSWYI QDLCELLQ-------RYGDS-HEFT-----------EVLTLVNRKVSMRSVG-NSSDRSA IGKKQVPCFAS-----MLTKKLYFRPKQ---------------- >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ -----------IPVSKSV------------------------------DSV--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------IEADESYRM---DH-PEMGLCILVNNK NFH--P-------ATGMSYRSGTDRDAAHVVDTFRTLGYMVKPYNDLTCKQIVDVLHNVS KD-D--HHKRNSFVCVLLSHGED-------GLIYGTD-------------GH-VELKMLT SFFRGDKCKSLAGKPKLFFIQACRG-----TEL-DSGI--E------TDS-AS------D E-SM---------------------CQKIPVEADYLYAYSTAPG--YYSWRNSSDGSWFI QSLCSMLK-------QYSHK-LELM-----------QILTRVNRKVT-EFTS-CSNHPDF HGKKQIPCIMS-----MLTKDFYFPH------------------ >A_gambiae_AGAP009832-PA ------------------------------------------------------------ -------QPLTKAFSAMFSRKQEDSSDTRGMPH--GSPI--------------------- --ASGSQTANGIIRPAYV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------IERYAAYYPM---NH-KRRGMALIFSHN KYN-VR-------NVSLPVREGSAIDCKRLKETLELFRFDVKVYPDFKLEEIKSVIGKVS SM-D--HSDSDCFLVAILTHGED------GGIVYAYD--------------QPYELSLIW SFFTADNCPSLAGRPKIFVVQACRG-----NQL-DHGVKVQ------KDG---------- -----------------------VARYSIPTHADFLFAYATIPG--FMAFRNTTEGSWFI NELCKELQ-------ENGHR-YDIN-----------TLLTFVTQKVAYDHES-VSNMPEY NMRKQTPCVVS-----MLTRLLLFNVV----------------- >R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDSETIN----PQPLQEERYDM---SG-ARLALTLCVT-- -----------------KAREGSEVDMDALERMFQYLKFESTMKRDPTAQQFLDDMDEFQ QTIENWKEPVSCAFVVLMAHGEE-------GFLKGED-------------GNMVRLEDLF EVLNNKNCKALRGKPKVYIIQACRG-----EHR-DPGEELP------GDELAV------- --------------------IKKKNPPTIPTYTDMIHIYSTVEG--FLSYRHDQKGSGFI QTLTDVFI-------HKK---GSIT-----------ELLEEITRLMANTEVM-----QEG KPRKVNPEIQS-----TLRKKLYLQ------------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ---------MEERHKKILQRNRTNLVGELDPSS--LYDGLIEKR-VFTHDMI-DEIKS-- SGTRRDQARQLIRDLETR------------------------------GSRAFPLFLECL QETGHHTLVELLQDG------GPAVQIQPPTPVPIDRPVIQPLPVCKSAI---R-SRVLR GTMTVKAAPPVDV-------VR-----RDKAPVIPVPQP--STAPSPSPER--------- ------------------------------------------------------------ -----------------EYMRLKPQGR----IRRDSIQSYKM---DA-NPSGHCLIINNV DFE--P-------RSELNDRKGSNTDCDRLESRFKALNFIVKVKTNLKQRQIKHELSALS KM-D--HSQYDCCVVVLLSHGTEVSHSRFPGAVYGVD-------------GQFVPVQHIT TYLNGQHCPSLQGKPKLFFIQACGG-----DEK-DTGFEVS------PDEFEPPVVSAHD Q-TDAIPMSS--SSDSLSMSDEPDARASLPTPSDILVSYSTFPG--YVSWRDTQSGSWYI ETLDRILE-------ENAAT-DDLV-----------TMLMMVNHEVSQNQAK-------- GLYKQMPGSFN-----FLRKLLYFQS------------------ >E_caballus_ENSECAP00000021726 ------------------------------------------MTSQGQNLNSSSDDNCTM DFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKK--LEKSSSALE-IFNHLLA-EDLLREE DSFFLAELLYIIKQKSLL-CHLCYTKEQVESLL--PARRRVSLF----RNLLYELSEGMD SDNL-NSMMFLLKDS------IPKTQM----TSLSLLAHLEKQARIDEDNLTLLEMLCKN VVPNLMRKIEKYK-------RE-----KAAQVVTAPVDK--ETESLHHGEEELFSRS--D IKKFSRALPQ--PWEHTHAGLGSLPLG--------N---SRVSKGWSSAL---------- --------------------ASGIGSI----SSSKETPLYRM---DR-THRGHCVVVNNH TFT--S----------LADRPGTDKDAECLKSVFQWLGFSVHRYDNVTKEGLEKVLQEYR NHPG--HASGDCFVFCVLTHGKF-------GAVYSSD-------------GILIPIREIM SHFTAQRCPALAHKPKLFFIQACQG-----EEV-QPSVSIE------ADA-VN------P E-NVTPS-------------LE----DSVPVEADFLLGLATVPG--YVSFRHVKEGSWYI QSLYNNLK-------DLVPRREDIL-----------SILTAVNDDVSRQVD-------IY GKKKQMPQPAF-----TLRKKLVFPVP----------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ --------MDKKESVDKICENKIFLLETLSVDANFILQHVQQAK-LITLRDY---NNLSD FPQRETKIINLLDKLMGK------------------------------GEETCHQFIALL RQDCVLENFPMLKDH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------DIFD----SSVQEISPYRI---IK-NPRGICVIINNE IFS-----------SGMMSRRGSDKDREYLAKVFHWLGFEVVEHNNKDTAEIRNILKDLG RTVD-----GDCFVCCILSHGRR-------EGVCGTD-------------GNYLSIDEIR DPFTGVKCQKLVGKPKLFFIQGCRG-----ANSLQACVKVE------ADAGN-------- --SKAKV-------------EGDNLDITIPSDTDFLIARSTTNG--HVSYRHVREGSWFI QSLCRNLE-------KHCPRGADIL-----------TILLYVNNEVSSQKSI-------- --RKQMPIYEV-----ALTRKLFLRPVNP--------------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ ---------MLSTHKEKLRTNRHTLCKELVVDE--LLQELIGEG-IFNDILA---DRVLS HQRDFKKNVEFLTLLPGR------------------------------GPNAFNAFRIAL INSDQSHLAELLDPA------QGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPG TSGTSAPLSRRRP-------ME-----NTDQSSTSIASS--QVIYANQGTPPKRNRESSS YIEQMDDAPSPTDSLSNIRSTASVHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQ INLHQGMDLFDGPTVSDLTVRKSTHQH----LMQHT-DCYQM-TMRG-RPKGAALIISVE KFH--P-------ESDLLNREGSEKDRVRLELVLQQIGFQCYVLINGTAEQIVSTLQTFA ELEE--HYDNSCSLVAAMSHGDA-------GCFYGSD-------------GVSVAIDTVV NFFSNQNCHSLQKKPKIFLFQACQG-----DEY-DMGVDE-------VDGPVQAPVGDVD NTSTSSS--------------NDHIRNKLPQKSDMLIGQATMKG--FAAMRNTKHGSWYI QAFVRVLA-------RHACD-TDLL-----------DMMTKVNNILKHKEGW--CPGSVY HRCKVMPEFKS-----SLSKKLYFFPGI---------------- >X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------ -----------MEESHNGVQYGEDTADAKTYFT--------------------------- ---NQQISLQNCDIKDME------------------------------KKT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KFAHLHKYRT---DY-PEMGICLIINNK NFQ--S-------STNMGVRNGTDVDARKLHETFTGLGYKVKVCNDQKSNDIFTLLKKMS EE-D--HSKRSSFVCAILSHGED-------GLVYGVD-------------GP-IQIKNLT DLFRGDRCKTLVGKPKLFFIQACRG-----TDL-DSGI--E------TDS-GS------E PGEE---------------------IQRIPVEADFLYAYSTVPG--YYSWRNTMNGSWFI QSLCEMIK-------LYGPH-LELI-----------QILTCVNHMVALEFES-CSTQQAF HAKKQIPCVVS-----MLTKAFYFLK------------------ >C_familiaris_ENSCAFP00000007585 -------------------------------------------------MERSPGSGGRW ECSGPPAPPELTPDVAELQSRVQETLELLSPQD--LRNFRLLLK-TVDEEPRVSPVKLEL EGRKKAGLARLVAQNYCE-------------------------------PAASRVLVKVL RQLRRADLLRLWQGA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------ADRGGERIPRKILKRSYD----CVDGELDRYDL---SG-SRKAFLMCVE-- -----------------KSRPGAHRDIELMKEWLGQCQFEHTACIDPNKMELLRKITLFR DGLNEIKGDVGCCLITLMSHGEN-------GFIKMED-------------GEKVNLQDIF EMFNNKNCPALQEKPKIFIIQACRGVLQNTERR-DSGVET-------DDEPMES------ --------------------DDVSEKRRLPTFSDYFIIYPTQAD--HVALRHPRTGSVMI EAMSEVFK-------QYGNK-WHIA-----------DFFTRVNNRVVHTEFH-----LHE EPIKVSLVMES-----TLTKSVYF--------------------