10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027012 ---------------------------------------------------------------------MAENKHPDKPLKVLEQLGKEVLTE--Y---------LEKLVQSNVLKLKE- R_norvegicus_ENSRNOP00000058685 ---------------------------------------------------------------------LTENNHPDKPLKVLEELGKEFLTE--Y---------LEKLVQSNVLKLKE- P_pygmaeus_ENSPPYP00000004373 ---------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--V---------LDNLVEQNVLNWKE- H_sapiens_ENSP00000347741 ---------------------------------------------------------------------MAEGNHRKKPLKVLESLGKDFLTG--V---------LDNLVEQNVLNWKE- P_troglodytes_ENSPTRP00000041705 ---------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--V---------LDNLVEQNVLNWKE- E_caballus_ENSECAP00000010831 ---------------------------------------------------------------------MAEDRQERNLLKTLESVGKELITG--L---------SVGLVEKDVLKLKE- C_familiaris_ENSCAFP00000031565 ------------------------------MYSSRQQHGLSLEHILKNGEIARDGKTYVVPIVEGVFVFLTEDKHDKNPFKILETVGKELITG--V---------LHGLLEKDILKLED- B_taurus_ENSBTAP00000027820 ---------------------------------------------------------------------MAEDKHNKNPLKMLESLGKELISG--L---------LDDFVEKNVLKLEE- P_pygmaeus_ENSPPYP00000004374 AVPIVEGVFIFLIEDSCKKKRRKNFEAVFKCILQSGLDNLVINHMLKNNVAGQTSIQTL-PNTDQKSTSVKKDNHKKKTIKMLEYLGKDVLHG--V---------FNHLAKHDVVTLKE- M_mulatta_ENSMMUP00000012893 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000007279 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNLVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- H_sapiens_ENSP00000376849 AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- G_gorilla_ENSGGOP00000015374 ------------------------------------------------------------------------DNHKKKTVKMLEYLGKDVLHG--V---------FNYLAKHDVLTLKE- M_mulatta_ENSMMUP00000012894 -----------------------------------------------------------------------------------------MLHG--V---------FNHLAKHDVLTLNE- E_caballus_ENSECAP00000021890 ----------------------------------------------------------------------TGNVLKEKRRLFIRSVGTGTVNS--L---------LDELLEKRVLNQEE- O_anatinus_ENSOANP00000016591 ---------------------------------------------------------------------PPAQLLKDRWCLIIESLTHGMISG--L---------LDDLLQMQVINQEE- P_pygmaeus_ENSPPYP00000004377 ---------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNKEE- E_caballus_ENSECAP00000006810 --------------------------------------------------------------------LAGRGPEKEDPVNLMKSIARNMFEG--F---------LDDL-ENNVLSRDD- M_domestica_ENSMODP00000034022 ---------------------------------------------------------------------LTDKVLMEKRRLFVESVDRGVMNG--L---------LDDLLEVQVLNLEE- P_troglodytes_ENSPTRP00000059619 ---------------------------------------------------------------------MADKFLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNQEE- H_sapiens_ENSP00000260309 ---------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--L---------LDELLQTRVLNKEE- M_domestica_ENSMODP00000034033 ---------------------------------------------------------------------LTDKVLKEKRRLFVESVDRGVING--L---------LDDLLELQVLNLEE- M_domestica_ENSMODP00000034020 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027821 ----------------------------------------------------------------------------EKRKLFVHSVSKGTING--L---------LDELLEKRVLNQEE- C_familiaris_ENSCAFP00000021904 --------------------------------------------------------------------VLTGKRQSQDPVNAIKVVASTMLNS--F---------LEDLKEKNVLNKQE- R_norvegicus_ENSRNOP00000029448 --------------------------------------------------------------------FTAKRTHERDPIYKIKGLAKDMLDG--V---------FDDLMDKNVLNGDE- M_musculus_ENSMUSP00000027009 --------------------------------------------------------------------MAARRTHERDPIYKIKGLAKDMLDG--V---------FDDLVEKNVLNGDE- M_musculus_ENSMUSP00000027015 ---------------------------------------------------------------------MADKILRAKRKQFINSVSIGTING--L---------LDELLEKRVLNQEE- P_pygmaeus_ENSPPYP00000004372 --------------------------------------------------------------------FTDEKPSNGVPVHMVKLLIRTFLDG--I---------FDDLMENNVLNTDE- M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000047678 --------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- O_cuniculus_ENSOCUP00000000956 ---------------------------------------------------------------------MADRILKDRRKRFINSVGTGTING--L---------LDELLEKRVLNQEE- R_norvegicus_ENSRNOP00000009993 ---------------------------------------------------------------------MADKILRAKRKQFINSVSVGTING--L---------LDELLEKRVLNQEE- H_sapiens_ENSP00000364878 --------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- G_gallus_ENSGALP00000001569 --------------------------------------------------------------------------LLRVRADFVSRVRKAVVSN--L---------LDELLAHRVLNQAE- M_mulatta_ENSMMUP00000012901 ----------------------------------------------------------------------TDKVLKEKRKLFIHSMGEASL----------------------------- X_tropicalis_ENSXETP00000017024 ----------------------------------------------------------------------LAAQLKKVRKLFIDGCNAAIINN--L---------LDDLLDKSVLTDSE- O_cuniculus_ENSOCUP00000006490 ---------------------------------------------------------------------------YKDVLKEMESAGKAIAGS--F---------MDNLVKKKVIKLEK- G_aculeatus_ENSGACP00000013201 ---------------------------------------------------------------------YFSDKLKKVRTKFVEKASMSLIKQ--L---------LDDLLDNGILNDGQ- D_rerio_ENSDARP00000034228 -------------------------------------------------------------------------MAKSIKDHLQDALSNIGADN------------LRRFQSRLGDRKQE- A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019853 ---------------------------------------------------------------------LP-DQLASIRPMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- T_rubripes_ENSTRUP00000013027 ---------------------------------------------------------------------MAICQLDSIRLMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- T_rubripes_ENSTRUP00000035020 ---------------------------------------------------------------------ME-DKLTSIRLMFVEKVSTQMINQ--L---------LDDIFMDGIVSEME- O_latipes_ENSORLP00000007938 -----------------------------------------------------------------------------------------------------------MLLQDKVLNDEE- D_rerio_ENSDARP00000059407 -------------------------------------------------------------------------KMEDITKLITDVLEELVESE--L---------KEFKRQLWMGVKKG- D_rerio_ENSDARP00000008601 ---------------------------------------------------------------------MTEEVNWDEDLEVDAVVQNLNLYKTVM---------RNDKNSNSEVQLSN- D_rerio_ENSDARP00000068268 --------------------------------------------------------------------------MEDITQLLSDVLEDLVESE--L---------KQFTRQLWIGVKPG- X_tropicalis_ENSXETP00000015203 -----------------------------------------------------------------MLGGMQKHHKDALQRLRVTLLHDMIIEEL-----------VEHLVSSGILTPIM- E_caballus_ENSECAP00000003321 --------------------------------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- G_gallus_ENSGALP00000029853 -----------------------------------------------------------------GACGMQRYHQEALKKNRVMLARELVLKEL-----------MEHMIEKDIITIEM- H_sapiens_ENSP00000312664 --------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- P_troglodytes_ENSPTRP00000033921 --------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- M_mulatta_ENSMMUP00000016588 --------------------------------------------------------------RILGVCGMHPHHQETLKKNRVMLAKQLLLSEL-----------LEHLLEKDIITLEM- B_taurus_ENSBTAP00000024166 --------------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVLAKELLLSEL-----------LEHLLEKDIITLEM- M_musculus_ENSMUSP00000031895 --------------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- R_norvegicus_ENSRNOP00000022672 --------------------------------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- P_pygmaeus_ENSPPYP00000020323 --------------------------------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- M_domestica_ENSMODP00000001598 --------------------------------------------------------------RMLGVWGMEQEHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- C_familiaris_ENSCAFP00000005409 --------------------------------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- T_guttata_ENSTGUP00000013612 ---------------------------------------------------------------MLAACGMQRCHQEALKKNRVMLAKQLVLNVL-----------VEHMVEKDIIPTEM- D_rerio_ENSDARP00000075318 ---------------------------------------------------------------------MADQLLENLRPDLIKGLSERVINGL-----------LDDLQQKKVFGEEE- A_carolinensis_ENSACAP00000006831 -------------------------------------------------------------SRMLGVCGMQKCHQEALKKNRVSLAKQLVLKEL-----------MEHLIEKDVITEEM- D_rerio_ENSDARP00000083664 ---------------------------------------------------------------MLGECGMTKWERLALRRNSVKMLQDLVVDDLL----------IQCLQQDGILTDSM- T_rubripes_ENSTRUP00000037606 -------------------------------------------------------------RSKMLHCGMREQDARTLRRQSAVLCKQLVVDELL----------IQCLQADDILTESM- C_elegans_C48D1.2 --------------------------------------------------------------------MMRQDRRSLLERNIMMFSSHLKVDEI-----------LEVLIAKQVLNSDN- T_nigroviridis_ENSTNIP00000010874 ----------------------------------------------------------------MLQCGMVERDAQALKKQSAVLFKQLVVDELL----------IQFLQADDILTDSM- O_latipes_ENSORLP00000015114 -------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDELL----------IQALVKDGILTQNM- O_anatinus_ENSOANP00000005545 ---------------------------------------------------------------------MQPCHQEALKKNRVALAKQLMLSEL-----------LEHLLEKDVITMEM- G_aculeatus_ENSGACP00000013740 -------------------------------------------------------------------CGMQERDRLALRTRSTVLCKQLVVDELL----------IQSLQTDEILTEAM- O_cuniculus_ENSOCUP00000001859 --------------------------------------MAAPSAGSRASLQQKGLLAADRGRRITAVCGMHPDHQETLKKNRVVLAKQLLLSEL-----------LEHLLEKDIITLEM- G_gallus_ENSGALP00000002083 ---------------------------------------------------------------------MEEAQRSALRRGRVRLVEGLRPEVL-----------WGPLQARGVFTSAM- B_taurus_ENSBTAP00000003205 ---------------------------------------------------------------------MNEADRLLLRRYRVRLVGELQVASL-----------WDALLSRELFTPDM- T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011776 --------------------------------------------------------------------MADEKPSNGVPVHMVKLLIKTFLDG--I---------FDDLMENNVLNTDE- C_elegans_Y48E1B.13a ----------------------------------------------------------------MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMS---------SSTTISTEDFNTIE- O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000017972 ---------------------------------------------------------------------MEEADRQLLRRCRVRLVRELQVAEL-----------WDALLSRELFTRDM- T_guttata_ENSTGUP00000017449 ---------------------------------------------------------------------MEERQRRALRRGRARLVAALRVEPL-----------WEPLEQRGLFTRPM- C_intestinalis_ENSCINP00000002956 --------------------------------------------------------------------AMKKRHRNTLIKNRVKLAKCLHLDEV-----------LQYLVQCGILTDVT- M_domestica_ENSMODP00000004412 ---------------------------------------------------------------------MEESQRELFQKNRLRLVCELQVEPL-----------WDLMLDRELFTRDM- D_rerio_ENSDARP00000047019 ---------------------------------------------------------------------MEQKHRQILQRHRLNLVKALNPEDV-----------CDKLLSKGVFTQDM- T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 ---------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFFLKELLFRINRIDLL---------NEPLNTKGPEMEREL M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 ---------------------------------------------------------------------MDEADRQLLRRCRVRLVSELQVAEL-----------WDALLSRELFTRDM- A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 --------------------------------------------------------------------MSKKESTQRILQHKVFLIDTLSVEASFI---------LQNVQQAKLITQRD- C_intestinalis_ENSCINP00000007986 ---------------------------------------------------------------------MLSTHKEKLRTNRHTLCKELVVDEL-----------LQELIGEGIFNDIL- A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040583 ---------------------------------------------------------------------MDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFKPHM- E_caballus_ENSECAP00000015102 ---------------------------------------------------------------------MNEADRQLLRRSRLRLVRELQVDSL-----------WDALLTRELFTPDM- T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002138 ---------------------------------------------------------------------MDEADRRLLWRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075650 --------------------------------------------------------------------MDKKESVDKICENKIFLLETLSVDANFI---------LQHVQQAKLITLRD- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 ---------------------------------------------------------------------MDEAERRALRRCRVRLVRELQVAAL-----------WDALLSRELFTAAM- M_domestica_ENSMODP00000032734 ---------------------------------------------------------------------MLQPDMESFKAQVVSTLTKLSPEE--------------------------- A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044662 --------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNPAAVQSAGDLFSRLSDQDHLSEEQPHLLVELLGIIQRTKLLRDHNLPRTGAQDLISPYSCKSRK- M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 ----------------------------------------------------------------------------EFRLLLHQICEGLTGENVSM---------MKFLCKDAIPRSRE- D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365051 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 ------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHLLSELLSIIQRTRLLRDLDLRSSATSNLISAY----RK- A_aegypti_AAEL003444-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 ----------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQL-----------WDALLSRELFRPHM- A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 ---------------------------------------------------------------------MEEIHKRILQRNRINLVRDLDPSSL-----------YDGLLEKGVFTQDM- C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000045375 ---------------------------------------------------------------------MEERHKKILQRNRTNLVGELDPSSL-----------YDGLIEKRVFTHDM- O_latipes_ENSORLP00000003208 ---------------------------------------------------------------------MEEKHKRILRRNRVHLVKELDLSDL-----------CDVLLRKDVFTQSM- D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 -------------------------------------------------MEGSLGSGRRSGSDGQPAPPKISPTTEELQSRLQETLDLLSSQE--------------------------- X_tropicalis_ENSXETP00000052017 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027012 -------------------------------------------------E-----------------DKQK------FNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFF--SVDPGSHH R_norvegicus_ENSRNOP00000058685 -------------------------------------------------E-----------------EKQK------FNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFL--NVDSGSHH P_pygmaeus_ENSPPYP00000004373 -------------------------------------------------E-----------------EKKK------YYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFF--NIDQISPN H_sapiens_ENSP00000347741 -------------------------------------------------E-----------------EKKK------YYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFF--NIDQISPN P_troglodytes_ENSPTRP00000041705 -------------------------------------------------E-----------------EKKK------YYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFF--NIDQISPN E_caballus_ENSECAP00000010831 -------------------------------------------------E-----------------ERKK------FYEAKPGDKPWVLVDSVRDRRHEAGQILWQALF--NIDRSVIS C_familiaris_ENSCAFP00000031565 -------------------------------------------------A-----------------EKKT------FYDAKPEDKPWVILNSVRQKRQEAGQALVHTFI--NTDKYSTS B_taurus_ENSBTAP00000027820 -------------------------------------------------E-----------------EKKK------IYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFL--NIDKNSTS P_pygmaeus_ENSPPYP00000004374 -------------------------------------------------E-----------------EKKK------YYNAKIEDKALILVDSVR-KNRVAHQIFIQTLL--DMDQKITS M_mulatta_ENSMMUP00000012893 -----------------------------------------------------------------------------------------MADSIQEKQRMAGQMLLQTFF--NIDQISPS P_troglodytes_ENSPTRP00000007279 -------------------------------------------------E-----------------EKKK------YYDAKIEDKALILVDSLR-KNRVAHQMFTQTLL--NMDQKITS H_sapiens_ENSP00000376849 -------------------------------------------------E-----------------EKKK------YYDTKIEDKALILVDSLR-KNRVAHQMFTQTLL--NMDQKITS G_gorilla_ENSGGOP00000015374 -------------------------------------------------E-----------------EKKK------YYDAKIEDKALILVDSXR-KKRVAHQMFTQTLL--NMDQKITS M_mulatta_ENSMMUP00000012894 -------------------------------------------------E-----------------EKEN------YYNVKIEDKALILVDSVR-KNRVAHQRFTQTLL--NMDQRITS E_caballus_ENSECAP00000021890 -------------------------------------------------M-----------------EKVR------DENATVMDKARALIDAVIRKGPQACQIFIGHIC--EDDPHLAE O_anatinus_ENSOANP00000016591 -------------------------------------------------M-----------------DTVR------EEHHRPAEKTRALLNSVIPKGDLASQIFIDSLC--KKNPFVAA P_pygmaeus_ENSPPYP00000004377 -------------------------------------------------T-----------------EKVK------RENATVMDKTRALLDSLIPKGARACEICITYIC--EEDSYLAE E_caballus_ENSECAP00000006810 -------------------------------------------------L-----------------RKLG------KRVNRIVNGTENLVEDLSEKTEVAGKIFLKHLL--KPKKQMNL M_domestica_ENSMODP00000034022 -------------------------------------------------M-----------------EIVR------EESKTNRDKARVLIDAVISKGPKASQCFTKSIC--ERDGHLAE P_troglodytes_ENSPTRP00000059619 -------------------------------------------------M-----------------EKVK------RENATAMDKTRALIDSVIPKGAQACQICITYIC--EEDNYLAG H_sapiens_ENSP00000260309 -------------------------------------------------M-----------------EKVK------RENATVMDKTRALIDSVIPKGAQACQICITYIC--EEDSYLAG M_domestica_ENSMODP00000034033 -------------------------------------------------M-----------------EILK------EESRTIRDKARVLIDAIISKGPKASQCFTKSIW--ERDGHLAE M_domestica_ENSMODP00000034020 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027821 -------------------------------------------------M-----------------EKIR------DENDTAMDRARVLIDTVIRKGPQACQICISHIC--EEDSHLAG C_familiaris_ENSCAFP00000021904 -------------------------------------------------L-----------------QTMG------QTVNVITKKTENLVGDLTEKTQVVGKIFKDHFL--NSGSLLSL R_norvegicus_ENSRNOP00000029448 -------------------------------------------------L-----------------LKIG------EGASLILSKAENLVESFFEKTEMAGKIFAGHIA--NSDKQLSL M_musculus_ENSMUSP00000027009 -------------------------------------------------L-----------------LKIG------ESASFILNKAENLVENFLEKTDMAGKIFAGHIA--NSQEQLSL M_musculus_ENSMUSP00000027015 -------------------------------------------------M-----------------DKIK------LANITAMDKARDLCDHVSKKGPQASQIFITYIC--NEDCYLAG P_pygmaeus_ENSPPYP00000004372 -------------------------------------------------I-----------------HLIG------TCLKFVVSNAENLVDDITQTAQIAGKIFREHLW--NSKKQLSS M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000047678 -------------------------------------------------I-----------------HLIG------KCLKFVVSNAENLVDDITETAQIAGKIFREHLW--NSKKQLSS O_cuniculus_ENSOCUP00000000956 -------------------------------------------------M-----------------EKVR------VENATVMDKARALLDCVIRKGPQACQICINHIC--EDDCHLAG R_norvegicus_ENSRNOP00000009993 -------------------------------------------------M-----------------DTIK------LANITVMEKARDLCDHVTKKGPRASQMFITYIC--NEDCYLAE H_sapiens_ENSP00000364878 -------------------------------------------------I-----------------HLIG------KCLKFVVSNAENLVDDITETAQTAGKIFREHLW--NSKKQLSS G_gallus_ENSGALP00000001569 -------------------------------------------------V-----------------DEVQ------EGNPVTTDKARSLIDTVRLKGPRASAIFIDSLR--KHDCNLAE M_mulatta_ENSMMUP00000012901 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017024 -------------------------------------------------V-----------------EYIN------ECNAITKDRCRRMIDNIKNKGDYSSNILLQCLV--ENHKTLAK O_cuniculus_ENSOCUP00000006490 -------------------------------------------------A-----------------KREK------FYDAKTHKKAQILVDSLREKCHEEDQKLTETFL--NIDQNSTG G_aculeatus_ENSGACP00000013201 -------------------------------------------------K-----------------DSIL------EENGTKADRARNLIDVVKAKGNKASEILIASLE--SRDSSLFS D_rerio_ENSDARP00000034228 -------------------------------------------------P-----------------RVRK------STIEKLKDEIDLVDLLVNTFTSDAVSVTVDILR--GIKCNAVA A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019853 -------------------------------------------------K-----------------ESIT------EESNIRSDKARRLIDSVRKKGERACKKMISHIQ--SRDPELSA T_rubripes_ENSTRUP00000013027 -------------------------------------------------K-----------------ESIT------EESNIRSDKARRLIDLVRKKGERACKKMISHIQ--SRDPELSA T_rubripes_ENSTRUP00000035020 -------------------------------------------------K-----------------ESIT------EESNIRSDKARRLIDSVRKKGERACKKMISHIQ--SRDPELSA O_latipes_ENSORLP00000007938 -------------------------------------------------R-----------------ESIC------EE-KSRADMARSLIDTVRKKGSTASKMMINHFE--QKDPILFS D_rerio_ENSDARP00000059407 -------------------------------------------------V-----------------EAIP------RGKLENKDRQDVVDYMVQHYSMDAGKIAVQALR--SIKQNERA D_rerio_ENSDARP00000008601 -------------------------------------------------ELVDFAVELTCGHRMPVDYVVAWFKCYLKQKETDFSCPHFIVDQGKTCGAKLSYQEICQLIPLSDKQREFL D_rerio_ENSDARP00000068268 -------------------------------------------------V-----------------EPIP------RGKLENKDRQDVVDSMVQQYSEDAGTITVQTLR--KIKQNERA X_tropicalis_ENSXETP00000015203 -----------------------------------------------------------------HSTIMA--------HRSEYKQNVTLLTQLPKRGPRAFSEFCNALH--ATGQRHLA E_caballus_ENSECAP00000003321 -----------------------------------------------------------------RELIQA--------KVTSFGQNVELLNLLPKRGPQAFEAFCVALR--ETKQGHLE G_gallus_ENSGALP00000029853 -----------------------------------------------------------------VEMIQA--------KSGSFSQNVEFLNLLPKRGPNAFSAFCEALQ--ETKQQHLA H_sapiens_ENSP00000312664 -----------------------------------------------------------------RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE P_troglodytes_ENSPTRP00000033921 -----------------------------------------------------------------RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE M_mulatta_ENSMMUP00000016588 -----------------------------------------------------------------RELIQA--------KVGSFSQNVELLNLLPKR-PQAFDAFCEALR--ETKQGHLE B_taurus_ENSBTAP00000024166 -----------------------------------------------------------------REHIQA--------KTGSFGQNVELLNLLPKRGPQAFDAFCVALR--ETKQSHLE M_musculus_ENSMUSP00000031895 -----------------------------------------------------------------RELIQA--------KGGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETRQGHLE R_norvegicus_ENSRNOP00000022672 -----------------------------------------------------------------RELIQA--------KGGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETRQGHLE P_pygmaeus_ENSPPYP00000020323 -----------------------------------------------------------------RELIQA--------KVGSFSQNVELLNLLPKRGPQAFDAFCEALR--ETKQGHLE M_domestica_ENSMODP00000001598 -----------------------------------------------------------------RELIQA--------KVGSFSQNVEFLNLLPKRGPHAFEAFCDALR--ETKQGHLE C_familiaris_ENSCAFP00000005409 -----------------------------------------------------------------REHIQA--------KVGGFSQNVELLNLLPKRGPQAFDAFCVALR--ETKQGHLE T_guttata_ENSTGUP00000013612 -----------------------------------------------------------------VEMIQA--------KSGSFDRNVEFLNLLPKRGPNAFSAFCEALR--ETQQQHLE D_rerio_ENSDARP00000075318 -----------------------------------------------------------------IEDIQH-------RMKTRADQARHVIDDVKRKGVKASEIMLASLK---TRDPHLY A_carolinensis_ENSACAP00000006831 -----------------------------------------------------------------MEMIQA--------KAGNFSQNIEFLNLLPKRGPKAFSAFCEALR--ETKQPHLE D_rerio_ENSDARP00000083664 -----------------------------------------------------------------AESIMA--------KPTSQGRSHQLLFLLPKRGPRAFSTFCSALK--ETEQHHLC T_rubripes_ENSTRUP00000037606 -----------------------------------------------------------------AESIMA--------EQTSQKRSWRLQLLLPKRGPKAFSSFCSALR--ATDQQHLC C_elegans_C48D1.2 -----------------------------------------------------------------GDMINS--------CGTVREKRREIVKAVQRRGDVAFDAFYDALR--STGHEGLA T_nigroviridis_ENSTNIP00000010874 -----------------------------------------------------------------AESILA--------EQTSHKRCWKLLHLLPKRGPKAFSSFCSALR--ETDQKHLC O_latipes_ENSORLP00000015114 -----------------------------------------------------------------AESIMV--------QKTSHHRSFKLLLLLPKRGPRAFKSFCSALK--ETEQEHLC O_anatinus_ENSOANP00000005545 -----------------------------------------------------------------RELIQA--------KAGSFSQNVEFLNLLPKRGPKAFDAFCAALR--ETKQGHLQ G_aculeatus_ENSGACP00000013740 -----------------------------------------------------------------AENIMA--------EQTSQKRSWRLLLLLPKRGPRAFSSFCSALQ--ETEQQHLY O_cuniculus_ENSOCUP00000001859 -----------------------------------------------------------------RELIQA--------RVGSFSQNVELLNLLPKRGPQAFDAFCVALR--ETKQGHLE G_gallus_ENSGALP00000002083 -----------------------------------------------------------------VEDMQS--------TGTRREQARQLVIDLETRGKQAFPIFLSILR--DTGHGDLA B_taurus_ENSBTAP00000003205 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLILDLETRGSQALPLFISCLE--DTGQDTLA T_guttata_ENSTGUP00000006879 -------------------------------------------------------------------------------MTDIGDGAHLGKDLADTKSIPGFK---GKNL---------- G_gorilla_ENSGGOP00000011776 -------------------------------------------------I-----------------HLIG------KCLKFVLSNAENLVDDITETAQIAGKIFREHLW--NSKKQLSS C_elegans_Y48E1B.13a -------------------------------------------------IESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCI O_anatinus_ENSOANP00000015596 -------------------------------------------------------------------------------AGTRRDQARQLVTDLETRGRRALSVFISCLR--ETDQHALA R_norvegicus_ENSRNOP00000017972 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLVIDLETRGRQALPRFISCLE--DTGQGSLA T_guttata_ENSTGUP00000017449 -----------------------------------------------------------------LEELQS--------AGSRGEQARQLIIDLETRGKQAFPAFLSILR--DTGQGHLA C_intestinalis_ENSCINP00000002956 -----------------------------------------------------------------VERITS--------KPTRFSQNVAFLTCLPTRGPRAYGTFLEALR--ISSQEHLV M_domestica_ENSMODP00000004412 -----------------------------------------------------------------IEDIQR--------AGTRRDQARQLVTDLQTRGKRALPIFISCLE--ATGQWDLA D_rerio_ENSDARP00000047019 -----------------------------------------------------------------IDEIQS--------KATRRDQARQLVKDLETRGSLAFPAFLDSLR--ETGHNDLA T_guttata_ENSTGUP00000004278 ---------------------------------------------------------------------------------MSGSERRPPAGHVQLDSRPTLPTT-DGNE---------- M_domestica_ENSMODP00000036247 QVPNKARISPYRLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVGPSELKSIKFMLS--SKIPKCKIEDDMTLMDLFIEMEKRGILGEGNLDALKIVCDQIDKSLL M_domestica_ENSMODP00000005560 --------------------------------------------------------------------------------------MEDTGTTVDAKSIKNSG---VKSL---------- O_anatinus_ENSOANP00000000517 --------------------------------------------------------------------------------------AASGEVMVDSKSFHSSQGYSSRKV---------- M_musculus_ENSMUSP00000030747 -----------------------------------------------------------------IEDIQQ------AGSGSRRDQARQLVTDLETRGRQALPLFISCLE--DTGQGTLA A_gambiae_AGAP004920-PA ----------------------------------------------------------------------VCGRDILHCKTMNTSTLSTAFDEVDNNTRVLSLVASVPEI---------- D_rerio_ENSDARP00000063081 -----------------------------------------------------------------YNNLSD--------VSERETKIIKLLDKLIGRGEETCQEFIDLLR---------- C_intestinalis_ENSCINP00000007986 -----------------------------------------------------------------ADRVLS--------HQRDFKKNVEFLTLLPGRGPNAFNAFRIALI--NSDQSHLA A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 --------------------------------------------------------------------------------------MEDTGTTVDAKSTKNSG---VKLF---------- G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------MMTDIKDGPRSGEDVSDARSFPGSK---GMNL---------- O_latipes_ENSORLP00000010095 -----------------------------------------------------------------------------------MASNRPGEDSTDARKDNGELAAGASPA---------- A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFVPSLFS----------- M_mulatta_ENSMMUP00000040583 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLITDLETRGSQALPSFISCLV--DTGQDMLA E_caballus_ENSECAP00000015102 -----------------------------------------------------------------IEDIQR--------SGSRRDQARQLIIDLETRGSQALLLFISCLE--DTGQDTLA T_nigroviridis_ENSTNIP00000022078 ---------------------------------------------------------------------MAGEAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLLFKS----------- P_pygmaeus_ENSPPYP00000017020 --------------------------------------------------------------------------------------MENTENSVDSKSIKNLE---PKVI---------- P_pygmaeus_ENSPPYP00000002138 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075650 -----------------------------------------------------------------YNNLSD--------FPQRETKIINLLDKLMGKGEETCHQFIALLR---------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 -----------------------------------------------------------------VEDLQH------AGSGSRSDQARQLVIDLETRGSQALPLFISCLE--DTGQDALA M_domestica_ENSMODP00000032734 --------------------------------------------------------------------------------------LRRFGIYLRNVGEEPRVSRHDLEM--ATKPEELA A_gambiae_AGAP009832-PA ---------------------------------------------------------------------------QPLTKAFSAMFSRKQEDSSDTRGMPHGSPIASGSQ---------- O_anatinus_ENSOANP00000019254 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000032189 ----------------------------------------------------------MGEQRNTSSKELAAAEATGQSGKELEVSMENTENSVDAKSFKNAE---TVIV---------- H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 --------------------------------------------------------------------------------------MENTENSVDSKSIKNLE---PKII---------- H_sapiens_ENSP00000311032 --------------------------------------------------------------------------------------MENTENSVDSKSIKNLE---PKII---------- D_rerio_ENSDARP00000019984 ------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKE-ALTSEIEVLEEDQDSYGEEDVTDAKPDRKGRFRLFGN----------- G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------SMQMAGEPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLLFKS----------- E_caballus_ENSECAP00000019797 --------------------------------------------------------------------------------------MENSKISVDSKSIKNSE---TKIL---------- B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------S----------- T_rubripes_ENSTRUP00000044662 -------------------------------------------------LLYSLSEELTADDLKDIKFLLN--NKLPRGKLEE-VTTLEVFMELEHRALISDTDLGFLESIIQPVCPVLL M_mulatta_ENSMMUP00000015808 --------------------------------------------------------------------------------------MENTENSVDSKSIKSLE---PKII---------- C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------MADDQDCGMEQAAGDSESPDAVDARPDRSSFVPSLFS----------- C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 -------------------------------------------------LETALDFMEYFEAKGWIQEGDL---GFLAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYRVVC D_melanogaster_FBpp0084848 -------------------------------------------------------------MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVAGSSH---------- M_musculus_ENSMUSP00000091238 --------------------------------------------------------------------------------------MENNKTSVDSKSINNFE---VKTI---------- G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------QVNGA-RLTSAQDVA--AEEGGPTGDQTDAKPDRRGRFLLFGNI---------- M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365051 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA R_norvegicus_ENSRNOP00000014096 --------------------------------------------------------------------------------------MDNNETSVDSKSINNFE---TKTI---------- O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 -------------------------------------------------LLYSLSEDLTDDNLKEIKFLLT--ETLPRRKLEDNVTTLEVFLELECMDLLSKTNLGLLKSILQPVCPVLA A_aegypti_AAEL003444-PA ---------------------------------------------------------------------------------------MDTTDELDVLGFGSRTNESSKSI---------- P_troglodytes_ENSPTRP00000056642 -----------------------------------------------------------------IEDIQR------AGSGSRRDQARQLIIDLETRGSQALPLFISCLE--DTGQDMLA A_gambiae_AGAP012544-PA ------------------------------------------------------------------------------MDATIINNNHSSLEAMDS------------------------ B_taurus_ENSBTAP00000021099 --------------------------------------------------------------------------------------MENTENSVDSKSIKTSE---TKIL---------- G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 -----------------------------------------------------------------IDEIKS--------AGTRRDQARKLVQDLETRGSRAFAMLLLCLE--ETDQHGLA C_intestinalis_ENSCINP00000003204 --------------------------------------------------------------------------------MSLKSAADVLMSGVPTPHTNENNNVGQSEV---------- T_rubripes_ENSTRUP00000040691 -------------------------------------------------------------------------------TNMSANGPSPGGDFTDAKKGAGQQPRSGSSS---------- T_rubripes_ENSTRUP00000045375 -----------------------------------------------------------------IDEIKS--------SGTRRDQARQLIRDLETRGSRAFPLFLECLQ--ETGHHTLV O_latipes_ENSORLP00000003208 -----------------------------------------------------------------INDIKR------QNCETKRDQARKLVKDLETRGNEAFSAFLEGLR--VTGQQNLL D_rerio_ENSDARP00000072390 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 --------------------------------------------------------------MTDECVTRNYGVGIRSPNGSENRGSFIMADNTDAKGCTPESLVVGGAT---------- G_gallus_ENSGALP00000019870 ---------------------------------------------------------------------------------MSGAERRPAAGRVQLDSKPTPTTTADGNQ---------- M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000012869 --------------------------------------------------------------------------------------LRSFRDHLKKVEPPVSQVKLELE---GHSPSGLA X_tropicalis_ENSXETP00000052017 -------------------------------------------------------------------------------MASAKQQSSPSAGQIEKDSSSASQNK-EQKA---------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000027012 GEANLEM----------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000058685 GEANLEM----------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000004373 KKAHPNM-----EAGP-------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000347741 KKAHPNM-----EAGP-------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041705 KKAHPNM-----EAGP-------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010831 RKALEEI-----AAGP-------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000031565 VEAFVEN-----MPGPTI------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027820 IKAPEET-----VAGP-------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000004374 VKPLLQI-----EAGP-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000012893 KKAHLNM-----EARP-------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000007279 VKPLLQI-----EAGP-------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000376849 VKPLLQI-----EAGP-------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015374 VKPLLQI-----EAGP-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000012894 VKSLLQI-----EAGP-------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000021890 TLRLSSG-----PQSGNFLKTQ-------------------------------------------------------------------------------------------------D O_anatinus_ENSOANP00000016591 KLGLSAG-----GQGQSGNTQFVGQSQ--------------------------------------------------------------------------------------------M P_pygmaeus_ENSPPYP00000004377 TLGLSAD-----QTSGNYLNMQ-------------------------------------------------------------------------------------------------D E_caballus_ENSECAP00000006810 KSLADYE-----DDESEDTES--------------------------------------------------------------------------------------------------P M_domestica_ENSMODP00000034022 KLGLSSE-----LNSNQSHISLCREQAPRPINICILR----------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000059619 TLGLSAD-----QTSGNYLNMQ-------------------------------------------------------------------------------------------------D H_sapiens_ENSP00000260309 TLGLSAD-----QTSGNYLNMQ-------------------------------------------------------------------------------------------------D M_domestica_ENSMODP00000034033 KLGLSS--------GKRKYLLGKADHSIHGEKLKTKQ----------------------------------------------------------------------------------- M_domestica_ENSMODP00000034020 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027821 ILGLTSG-----SQSENYLR-Q-------------------------------------------------------------------------------------------------K C_familiaris_ENSCAFP00000021904 SWSSTSA-----TKPSGSCRPS-------------------------------------------------------------------------------------------------Y R_norvegicus_ENSRNOP00000029448 LQADRNQ-----ITGPSFQILV-------------------------------------------------------------------------------------------------F M_musculus_ENSMUSP00000027009 -QFSNDE-----DDGPQ-KICT-------------------------------------------------------------------------------------------------P M_musculus_ENSMUSP00000027015 ILELQSA-----PSAETFVATE-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000004372 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000047678 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000956 LLGLSSG-----PQSENHFNAQ-------------------------------------------------------------------------------------------------D R_norvegicus_ENSRNOP00000009993 ILELQSG-----PSAETVFVTE-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000364878 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000001569 QLRLCAH-----AEPPGAPLAAPSTVGFSDP----------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000012901 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017024 NMGLDVS-----EPAIAPQPIQEQNKK--------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000006490 MQXXXXX-----XXXX-------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013201 ELGLSSA-----QTAPPAISGVSNIF---------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000034228 EELLENT-----GQVYSIFKLCKKNSHYTKPPIIITDVFMFCFLGGVSQP---------------------------------------------------------------------- A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019853 VLGLSCG-----HPAPP--------GELRDDTLFQTDRIVSFRF-----QP--------------------------------------------------------------------- T_rubripes_ENSTRUP00000013027 VLGLSCG-----HPAPP--------GELR-------GQLESPAF-----ST--------------------------------------------------------------------- T_rubripes_ENSTRUP00000035020 VLGLSCG-----HPAPPVFNRRAPDGRSR-------VIFNSPINRCVLEGE--------------------------------------------------------------------- O_latipes_ENSORLP00000007938 ELGLSCP-----EPAQT------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000059407 NRLESKL-----LEAVSSSDLFQPQAQENEQNPEDP----------------QSINTSG------------------------------------------------------------- D_rerio_ENSDARP00000008601 EENLAAI-----VARRLFDFKSCPGCQ--------------------------------------------------------------------------------------------S D_rerio_ENSDARP00000068268 KRLESNL-----LKV-------QSQGQENKQNSEEPQPIPQIISQPIQQIISQPINNAGSEDLQPI------------------------------------------------------ X_tropicalis_ENSXETP00000015203 EQLEEEA----------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000003321 DLLLTTL----------------------------------------------------------------------------------------------------------------S G_gallus_ENSGALP00000029853 EMILKTE----------------------------------------------------------------------------------------------------------------S H_sapiens_ENSP00000312664 DMLLTTL----------------------------------------------------------------------------------------------------------------S P_troglodytes_ENSPTRP00000033921 DMLLTTL----------------------------------------------------------------------------------------------------------------S M_mulatta_ENSMMUP00000016588 DIELKLR----------------------------------------------------------------------------------------------------------------V B_taurus_ENSBTAP00000024166 ELLLRTL----------------------------------------------------------------------------------------------------------------S M_musculus_ENSMUSP00000031895 DLLLTTL----------------------------------------------------------------------------------------------------------------S R_norvegicus_ENSRNOP00000022672 DLLLTTL----------------------------------------------------------------------------------------------------------------S P_pygmaeus_ENSPPYP00000020323 DMLLTTL----------------------------------------------------------------------------------------------------------------S M_domestica_ENSMODP00000001598 DLLHRTL----------------------------------------------------------------------------------------------------------------Y C_familiaris_ENSCAFP00000005409 DLLLTTL----------------------------------------------------------------------------------------------------------------S T_guttata_ENSTGUP00000013612 TLILKTM----------------------------------------------------------------------------------------------------------------S D_rerio_ENSDARP00000075318 DTLGIE------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006831 EMLLLNL----------------------------------------------------------------------------------------------------------------I D_rerio_ENSDARP00000083664 KLLMDFT----------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037606 DLLTQTF----------------------------------------------------------------------------------------------------------------- C_elegans_C48D1.2 EVLEPLA-----RSVDSNAVEFECPMS-----------------------------------------------------PASHRRSRALSPAGYTSPTRVHRDSVSSVSSF--TSYQDI T_nigroviridis_ENSTNIP00000010874 DLLARTS----------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000015114 DLLTQ------------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000005545 DLLYRTL----------------------------------------------------------------------------------------------------------------S G_aculeatus_ENSGACP00000013740 ELLIQSS----------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001859 DLLLTTL----------------------------------------------------------------------------------------------------------------S G_gallus_ENSGALP00000002083 DMLDEGC-----GSPMSPPVDL-----------------------------------------------------------------------------------RPVQLEL--PGERRD B_taurus_ENSBTAP00000003205 SLLKTSR-----QAAKQ------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011776 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y48E1B.13a ETVKKKF-----QPLLPNAIQTCEFDEETMI-----------------------------------RMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGT--HRSGFT O_anatinus_ENSOANP00000015596 ALLSEGC-----QAPQVTPVDI-----------------------------------------------------------------------------------RPVEIIR--PGGQGD R_norvegicus_ENSRNOP00000017972 SFLQSSG-----QAAKQDPEAV-----------------------------------------------------------------------------------TPLDHLV--PVVLGP T_guttata_ENSTGUP00000017449 EMLMQEC-----ESRPVPPQLP---------------------------------------------------------------------------------DLRPVELELQEANQRCA C_intestinalis_ENSCINP00000002956 DILEKVD----------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004412 ALLSESN-----TTLTQQPDPI---------------------------------------------------------------------------------DIKPVEMIR--SGGLRS D_rerio_ENSDARP00000047019 ELLQSGDGVHRPPVISVQPSPI-------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 KKIQEYE-----ISKGRNNLFL-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 SLLQSGR-----QAAKQDPEAV-----------------------------------------------------------------------------------KPLDHLV--PVVLGP A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000063081 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 ELLDPAQGVSQPNESNANDGSGGPELS-------------------------------------------ASIFRFESIATANSNLPGTSGTSAPLSRRRPMENTDQSSTSI--ASSQVI A_carolinensis_ENSACAP00000013788 ----------------------------