10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 M----------------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 ----------------------------------------------------------------------------------------IETMKSKGLEPSGQPGVLSLKNPILTQSTDLQ M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 MLEKPPGHVSTHSDILSLENRCLATLPDLKTLEKPPGHMSAHSDILSSENRCLATLPDLKTLEKPPGHVSAHSDILSLENRCLATLPDLKTLEKPPGHVSAHSDILSLENRCLATLTILK H_sapiens_ENSP00000262715 M-EKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLK C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 M-EKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001276-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021364 --KKPHGHVSAHPDILSLEKRCLAMLPDLQPMKKLHQHISAHSDILSLKNQCLATLPDLKTVEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK P_pygmaeus_ENSPPYP00000006332 M-EKLHGHVSAHPDILSLENRCLAMLPDLQPMEKLHQHISTNSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENRCLATFSDLKTMEKPHGHVSAHPDILSLENRCLVTLPSLK O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 M-EKLCGYVPVHPDILSLKNRCLTMLSDIQPLEKIHGQRSVNPDILSLENRCLTLLPDLQPMEKIHGQRSVHPDILSSENRCLTLLPDLQSLEKLCGHMSSHPDVLSLENRCLATLPTVK S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 -------------------------LPDLKTMEKPHGHVSAHPNILSLENRCLSTLPDLKTVEKPHGHVSSHPNVLSLENRCLATLPDLKTVEKPHGHVSAHPNVLSLENRCLATLPILK M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 M-EKLCGHVPGHSDILSLKNRCLTMLPDLQPLEKIHGHRSVHSDILSLENQCLTMLSDLQPTERIDGHISVHPDILSLENRCLTMLPDLQPLEKLCGHMSSHPDVLSLENQCLATLPTVK H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 STVSASHLLQPFQPSPLIEASLKGMDTSNHLLLEPAARKAQDFTLGHFTKWPKRTLKAKLAK---RKSVRGSWMAQWIEEEEEEEEQVEEAIPLYNLSLR--KEKESEELMLELVSRDSD M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 STVSISPLLQNLQISHLAQADLCSLNSSNHLLSEHPASRVQYLSEGRGLLTCPRVSKTISAPERVQEAVLGRWSSSGEKKPEEK-EWAEAQMPFYRLSLG--EEEEVEELALKLTPGDSE H_sapiens_ENSP00000262715 STVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISATETAQEATLGRWFDSEEK------KGAETQMPSYSLSLG--EEEEVEDLAVKLTSGDSE C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 STVSASPLFQSLQISHMTQADLYRVNNSNCLLSQPPSWRAQHFSKGLDLSTCPIALKSISATETAQEATLGRWFDSEEK------KGAETQMPSYSLSLG--EEEEVEDLAVKLTSGDSE S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001276-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021364 STVSASRLFQSLQISHMTQADLYCVNNSNCLLSEPPSWSAQHFSKGLDLSTCPTALKSLSATGTVQEATLGRWFDSEEK------KGAETQMPSYSLSLG-EEEEEVEDLALKLTSGDSE P_pygmaeus_ENSPPYP00000006332 STVSASPLFQSLQISHMTQADLYCLNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKSISATETAQEATLGRWFDSEEK------KGAETQMPSYSLSLG--EEEEVEDLAVKLTSGASE O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 RTVSSGPLLQCLHRSHTAQADLRDPNFRNCLFPEPPTIEAPCFLKELDLPTGPRALKSMSATARVQEVALGQRCVSEGKELQEEKESAEVPMPLYSLSLGGEEEEVVGAPVLKLTSGDSD S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 STVSASALLQRLQTFHPVQADLCSLNTSNHLLSEPPTWRAQYLSEGLGLLTFPGALQSISATETVQEAAVGHWSSSEEKRPGAE-EWAEAPMPFYSLSLG--EEEEVEELALKLTSGESE M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 STALTSPLLQGLHISHTAQADLHSLKTSNCLLPELPTKKTPCFSEELDLPPGPRALKSMSATAQVQEVALGQWCVSKEKEFQEE-ESTEVPMPLYSLSL---EEEEVEAPVLKLTSGDSG H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMI---------------------------------------------------------- E_caballus_ENSECAP00000022364 -------------------------------RMDAKARNCLLQHREALEKDIKTSYIMDYMI---------------------------------------------------------- B_taurus_ENSBTAP00000028867 ------------------------------GKMDAKARNCLLQHREALERDIKTSYIMDHMI---------------------------------------------------------- P_troglodytes_ENSPTRP00000042795 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMI---------------------------------------------------------- P_pygmaeus_ENSPPYP00000005543 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMI---------------------------------------------------------- H_sapiens_ENSP00000353059 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMI---------------------------------------------------------- R_norvegicus_ENSRNOP00000010869 --------------------------------MDAKARNCLLQHKEALEKDIKTSYIMDHMI---------------------------------------------------------- M_mulatta_ENSMMUP00000038848 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMNHMI---------------------------------------------------------- C_familiaris_ENSCAFP00000009806 ------------------------------GRMDAKARNCLLQYREALEKDIKTSYIMDRMI---------------------------------------------------------- O_anatinus_ENSOANP00000008896 ------------------------------GRMDARARNCLLKHMEALEKDIKTSYIMDHMI---------------------------------------------------------- M_domestica_ENSMODP00000009538 -------------------------------RMDAKARNCLLQHKEALERDIKTSYLMDHMI---------------------------------------------------------- T_guttata_ENSTGUP00000009081 -------------------------------NMDVKSRNYLLMNRQALENDIKTSYIMDRMI---------------------------------------------------------- G_gallus_ENSGALP00000037436 --------------------------------MDENSRMCLITNRQALEKDIKTSYIMDHMV---------------------------------------------------------- A_carolinensis_ENSACAP00000012965 -------------------------------TMDLTARSHLLQNREALERDIKTSYVIDHMI---------------------------------------------------------- X_tropicalis_ENSXETP00000014654 --------------------------------MDEKARSLLLQNRTALVRDIRTAYIMDHMI---------------------------------------------------------- G_gorilla_ENSGGOP00000008216 --------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMI---------------------------------------------------------- D_rerio_ENSDARP00000008347 --------------------------------MEERARSRLLRSKATLEQDIKASYLMDHMI---------------------------------------------------------- O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 --------------------------------LEEGARSSLLRFRHQLEQDIKPSYLMDHMI---------------------------------------------------------- T_nigroviridis_ENSTNIP00000013938 --------------------------------LEERARSCLLRFRHQLEQDIKPSYLMDHMV---------------------------------------------------------- G_aculeatus_ENSGACP00000026214 --------------------------------LEEGARSCLMRFRHRLEDDIKPPYLMDHMV---------------------------------------------------------- O_latipes_ENSORLP00000019346 --------------------------------LDERARACLLKSRHKLEEIMKPAYLMDHMI---------------------------------------------------------- C_elegans_Y45F10B.10 ---------FRGKGQQQVSSTDNIKAMMTAAIGNKLEKRLPLVSTIFVVGNDEEEFNIERRTLWQDVLPDLQNLAFQSNF---------------------------------------- C_intestinalis_ENSCINP00000010464 -------------------------------------------------MGITKQYLRYLSV---------------------------------------------------------- M_domestica_ENSMODP00000008927 AQPENTDQVLQDKKMLLITKLCCALSSRANLLEAKDPTRNFLLQLCTDLALLEPEFILKASLYARQQLNIRDMAIMVLAIAAYLPACRPYLRRYFCAIVQLPSDWMQVAQYFQNLAESPD M_domestica_ENSMODP00000027702 --------------ADLDQADRGILSGWGWSHGQGPGDGAGTVEQGAEVGWASNVYAVQRRI---------------------------------------------------------- T_nigroviridis_ENSTNIP00000004057 -------------------------------------------NMASSHLHFKTNYAVSSKI---------------------------------------------------------- T_guttata_ENSTGUP00000006840 ---------------------------------------------------FPSSYAATRKI---------------------------------------------------------- B_taurus_ENSBTAP00000001564 SHPEPTEQVLQEVKMVLMSFLCSSLVANVNRNDAAYSTQAFLLKVCSEVARFEPEFVLKASLYTRQQLNVRDVANKVLAIAAFLPLCRPYLRRYFCAIVQLPSDWIQVARFYELLCREQE H_sapiens_ENSP00000262715 SHPEPTDHVLQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDK C_intestinalis_ENSCINP00000019387 -------------------------------------------------LQLRTKYDLIKKW---------------------------------------------------------- G_gallus_ENSGALP00000008904 ----------------------------------------MAATAAGSVVRFKSNYAVSRRI---------------------------------------------------------- P_troglodytes_ENSPTRP00000010340 SHPEPTDRVLQEKKMALLSLLCSTLVSEVNVNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDK S_cerevisiae_YLR222C -------------------------------------------------MDLKTSYKGI-SL---------------------------------------------------------- G_aculeatus_ENSGACP00000015863 --------------------------------------------MANTNLQFKTNYAVESKI---------------------------------------------------------- B_taurus_ENSBTAP00000027147 -----------------GDAISASPRCGMAPGSPSRGGTGDMAEVAAGVGRFKSNYAVERKI---------------------------------------------------------- A_gambiae_AGAP009615-PA ----------------------------------------------SPLICGSRRYEVKQQY---------------------------------------------------------- D_rerio_ENSDARP00000023281 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- T_rubripes_ENSTRUP00000017221 --------------------------------------------MANPHLHFKTNYAVSSKI---------------------------------------------------------- A_gambiae_AGAP004827-PA ----------------MATAIEEAVFNALRGHHNEHTKLPSPRIIKIYIASLKDDFKEERRL---------------------------------------------------------- A_aegypti_AAEL001276-PA ----------------MAAIIEEAVFNALRGHHNEKTKLPSPRIIKIYVASLKEDFKEERRL---------------------------------------------------------- M_mulatta_ENSMMUP00000021364 SHPEPTDQVLQEKKMALLSLLCSTLVSEVNMKDASDPTLAAIFENCRELAPLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDE P_pygmaeus_ENSPPYP00000006332 SHPEPTDHVLQEKKMTLLSLLCSTLVSEVNMKDASDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGDK O_anatinus_ENSOANP00000004860 -------------------------------------------------MGLTRQYLRYVAG---------------------------------------------------------- D_melanogaster_FBpp0085899 ----------------MAAPIDESVLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRM---------------------------------------------------------- O_latipes_ENSORLP00000010395 -------------------------------------------------MGLTKQYLRYAPS---------------------------------------------------------- R_norvegicus_ENSRNOP00000012235 SHPETTDQILQEKKMALLTLLCSAMASSVNVKDASDPTRASIHEVCSALAPLEPEFILKASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDE S_cerevisiae_YCR057C ---------------------------------------------------MKSDFKFSNLL---------------------------------------------------------- G_gorilla_ENSGGOP00000009169 -----------------------------------------MAETAAGVGRFKTNYAVERKI---------------------------------------------------------- T_nigroviridis_ENSTNIP00000007980 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- H_sapiens_ENSP00000331815 -----------------------------------------MAETAAGVGRFKTNYAVERKI---------------------------------------------------------- M_mulatta_ENSMMUP00000010429 -----------------------------------------MAETAAGVGRFKANYAVERKI---------------------------------------------------------- X_tropicalis_ENSXETP00000035244 ----------HILQMELVSAVCCSLVRGPKFSDSCDETRVKLLALCEELSNLDPEFILKVALYTRQELNIRSTANFMLAVSAFLPACRPHLRRYFCASVQLPADWMEIPRLYQSLA-GQG P_troglodytes_ENSPTRP00000001997 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- P_pygmaeus_ENSPPYP00000007898 -----------------------------------------MAETATGVGRFKANYAVEHKI---------------------------------------------------------- M_musculus_ENSMUSP00000046830 -----------------------------------------MAETAAGLCRFKANYAVERKI---------------------------------------------------------- R_norvegicus_ENSRNOP00000018405 -----------------------------------------MAETAAGLCRFKANYAVERKI---------------------------------------------------------- A_aegypti_AAEL004526-PA --------------------------------------------------MKKNEYEVQNQY---------------------------------------------------------- P_pygmaeus_ENSPPYP00000001131 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- P_troglodytes_ENSPTRP00000053800 -----------------------------------------MTETAAGVGRFKTNYAVERKI---------------------------------------------------------- M_mulatta_ENSMMUP00000011166 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- R_norvegicus_ENSRNOP00000026726 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- O_anatinus_ENSOANP00000015573 ---------------------------------------------QEPSRSLPRSYAVSRKI---------------------------------------------------------- T_guttata_ENSTGUP00000013749 -------------------------------------------------MGLTRQYLRYEPA---------------------------------------------------------- C_familiaris_ENSCAFP00000028736 -------------------RHRSAPAVGSGAPVRSRGGGG-GGVMAEPVGRFKANYAVERKM---------------------------------------------------------- X_tropicalis_ENSXETP00000015707 ------------------------------------------YPDPCFGLFAFSSYAVTRKI---------------------------------------------------------- E_caballus_ENSECAP00000009299 SCPEPTDRALQEKKMTLMSLLCSTRASNVNMKDAADPTAASLFEICSELAPLEPEFILKASLYTRQQLNVRDVANRVLAIAAFLPVCRPYLRRYFCAIVQLPSDWIQVAEFYQSLAEGEE M_domestica_ENSMODP00000006461 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- M_musculus_ENSMUSP00000006444 FHPETTDQVLQEKKMALLTLLCSALASNVNVKDASDLTRASILEVCSALASLEPEFILKASLYARQQLNLRDIANTVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGDE H_sapiens_ENSP00000308179 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- T_rubripes_ENSTRUP00000006345 -------------------------------------------------MGLTKQYLRYVAS---------------------------------------------------------- E_caballus_ENSECAP00000017445 ------------------------------------GGGGDMAEAAAGGSRFKANYAVERKI---------------------------------------------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 KKLVPMPACLRAAMTEKFTQFDEYQLAKYNLREHRAKKRRRRYRRPVSDFFPVSSHRSNPLYLGTKRAKQNRKFMRAYHEEPVKKKPSDFTLKKLIKRLHIRDPVQNVKALLGCRYPSDL M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 DCLAPLPACLRAAMRDKFSQFDEYQLAKYNPRKHRAKRRPRRPPRPPK-EHTFSETQTYLPRFIWHIRGEQRMFETTYGSVSEKKTEQRFTLKKLVRRLHIHEPAQLVQALLGCRYPSNL H_sapiens_ENSP00000262715 NKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFSHRC--FPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNL C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 NKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPHRPPRSPRMEPPFSHRR--FPRHIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYPSNL S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001276-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021364 NKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPRMEPPFSRRP--FPRYIVFLRDEQKKFEKAYDTVSEKKNPPRFTLKKLVQRLHIHEPAQHVQALLGYRYPSNL P_pygmaeus_ENSPPYP00000006332 NKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRCPRMEPPFSCRP--FPRYIVCLREEQRKFEKACDTVPEKKNPPRFTLKKLVQRLHIHEPAQHVQALLGYRYPSNL O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 KKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRSKTRSRQPPRPQRTKPPFSESGKCFPKSVWPLKNEQISFEAAYNAVSEKKRLPRFTLKKLVEQLHIHEPAQHVQALLGYRYPSTL S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 EKLAPLPSCLRRVLTVKFQKFTEYQLAKYNTRRQRGKHSIRKPKLSRFLNFLFFHIFPLVVDKGLKLLQKKF----STPPTPKMKTKDRFSMKSLIQRLHISKPTHHVMGILGCKYPKDL P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 NKLVPLPSCLRAAMTDKFAQFDEYQLAKYNPRKHRAKSRPRRRPHPPKTEHPFSERQRYLPKCLAPLMDEQKKFEASYNVVPEKKKQPRFTLKKLVQRLHIKEPAQHVQALLGYRYPSNL M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 KKLVSLPACLRAAMTDKFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKTERPFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLVEYLHIHKPAQHVQALLGYRYPATL H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 QSFSRSRLPGPWDSSRAGTRMKLPQPETWERVLSQQGNTASVWEGLIDSGKLPYMAMLRNLCSLLRVGISAKHHERILQLLERKESVIRSRQLPFRFLSAHTSISDLERQLKNSG-PVPC M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 QAFSRSRLPGPWDSSRAGKRMKLARPETWERELSLRGNKATVWEELIDSGKLPFMAMLRNLRNLLRVGISARHHELVLQRLQHAKTVIHSRQFPFRFLNAHDSINDLEAQLEKKELPFPS H_sapiens_ENSP00000262715 QLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPS C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 QLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNHALPFPS S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001276-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021364 QLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISARHHELILQRLQHAKSVIHSRQFPFRFLNAHDSIDALEAQLRNQALPFPS P_pygmaeus_ENSPPYP00000006332 QLFSRSRLPGPWDPSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISARHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALPFPS O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 ELFSRSHLPGPWDSSRAGQRMKLQRPETWERELSLRGNRASVWEELIDNGKLPFMAMLRNLCNLLRTGISAHHHELVLQRLQHEKSVIHSRQFPFRFLNAHDSLDRLEAQLRSKASPFPS S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 YSFSKSGLEGPWQSDLSGQKMKLKQPQTWDRELSLKGNTGLVWEKLLDSDQVPFMALLRNLRNMIRAGISRQHHNQVTSRLSSERAVIKSRMFPFRFLSAYKVIQDLENQCHVSGKPFPV P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 QAFSRSRLPGPWDSSRAGKRMKLSQPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRVGISPRHHELVLQRLQHAKSVIHSRQFPFRFLNAHDSINDLEAQLKSKALPFPS M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 ELFSRSHLPGPWESSRAGQRMKLRRPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRTGISARHHELVLQRLQHEKSVVHSRQFPFRFLNAHDSIDKLEAQLRSKASPFPS H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 NVVIMRQLLERLEKKKKLPKPERKL---TNWDLRFAMMVPVLYEHFKREKQRLIQISHWKRDWEMMKRYQQALETAMNLSVQHNLPPLPGRTLIICSPYESQDKKKVKKNQN--PLTHVL M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 NTQLIKQIIIKNTKYGKKHAYSWQFRQPSRRELRTAMMIPVIYEQLKRKKMKIHKARQWKCDREMLARYRQALETAVNLSVKHSLPPLPGRTLLVYLTDASADRILPKSNPQGPPLNYVL H_sapiens_ENSP00000262715 NITLMRRILTRNEKNRPR---RRFLCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLNYAL C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 NITLMRRILTRNEKNRPR---RRFLYHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAMNLSVKHSLPLLPGRTVLVYLIDANADRLCPKSNPQGPPLNYAL S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001276-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021364 NTTLMRRILTRSDKNRPR---RRFLCHLSCQQLRTVMRVPVMYEKLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTILVYLTDANADRLCPKSNPQGPPLNYAL P_pygmaeus_ENSPPYP00000006332 NITLMRRILTRNDRNRPR---RRFLCHLSRQQLRTAMRIPVLYERLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTVLVYRTHANADRLCPKSNPQGPPLNYAL O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 NTTLMKRIMIRNSKKIKRPANPRYLCTLTQRQLRAAMAIPVMYEHLKREKLRLHKARQWTCDLELLERYRQALETAVNISVKHNLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLNYVL S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 NVRLIKNIVTSEAASIP----ELKRYTWSRRQLRGCLAVPAIRQLLKRKKEALRKLRACKMDQAILQKYKKALESAVKISARYNITPLPGRTVILFYVSESMDKPCHGAK----DLKVGL P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 NTKLMRQIMIRNSKNIKRHAYQKKLCNPSRRELRAAMMVPLMYEQLKREKLKIHKSRQCKYDSETLARYRQALETAVNLSVKHSLPPLPGRTLLVYMTDAEADKLCPKNNPQGPPLNYVL M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 NTTLMKRIMIRNSKKNRRPASRKHLCTLTRRQLRAAMTIPVMYEQLKREKLRLHKARQWNCDVELLERYRQALETAVNLSVKHNLSPMPGRTLLVYLTDANADRLCPKSHSQGPPLNYVL H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 LLVAMLMARAEQAELLLCKRGTLKKAVTNPEEGILKTA-TELETQIQAFHGEISESGHHPFVTYLLDMVTRRVLMDTVIFVGNTMKDFEFMTAKQFFWQRVNPKCLFVGVDLMGMDSCSL M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 LLIAMMMVRTEQVELLLCGGGIVKTAVIKAEEGILKTA-TELQAQVQKSDES-CEQSLTTLGKHLLSLATQRVPVDRVIVFGQTTNEKLINAAKQLFWQHVNPKCLFVGVLL-RASYLCT H_sapiens_ENSP00000262715 LLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTA-IKLQAQVQEFDEN-DGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLST C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 LLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTA-IKLQAQVQEFDEN-DGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQYLST S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA ----------------------------------------------------------------------------------------------------------LLEIIGPDLQALYD A_aegypti_AAEL001276-PA ----------------------------------------------------------------------------------------------------------LLEVIGPDLQSVYD M_mulatta_ENSMMUP00000021364 LLIGMMITRAEQVDVMLCGGDTLKTAVLKAEEGILKTA-IRLQAQVQEFDEN-GEWSLNTFGKYLLSLAGQRVPADRVILFGQSMDEGMINVAKQLYWQHVNSKCLFVGVLLRRVQYLSP P_pygmaeus_ENSPPYP00000006332 LLIGMMITRAEQVDVVLCGDDTLKTAVFKAEEGILKTA-IKLQAQVQEFDEN-DGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDEGMINVAKQLYWQRVNSKCLFVGIILRRVQYLSP O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ----------------------------------------------------------------------------------------------------------LLELVGPELQSLYD O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 LLIGMMMARAEQTTVWLCGTGTVKTPVLTADEGILKTA-IKLQAQVQELEEN-DEWPLETFEKYLLSLAVRRTPIDRVILFGQRMDTELLNVAKQIIWQHVNSKCLFVSVLLRKMQYIDP S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 LLSGMVRDTSESAQVVLFNDQTYILAEFNSSSLLHNVSHLKKQAEDLKSQGRYSSRNKNVAKKYLMELLANRTKVDTLLLFRLSPPSAEFKSVLKQYRREVNTDCLCVTVVPENLQREES P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 LLIGMMIARAEHADLLLCGSGTLKTAVLKAEEGILKTA-IELHAQVQELDGNYYEFSRDTFGKYLLSLAAQRVPVDRVILFGHIMNGSLINEAKQLFWQHVNSKCLFVGVCLRRICYTFS M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 LLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTA-IKLQAQVQELEGN-DEWPLDTFGKYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISP H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ----DLEFCDVPLENGELTNSVAEH--------------VLQMWKDNPRSWIVLLLGNRYGNVSVPTSLRKEEYESIRSSIFEENGNVRVFEKAY------------------------- C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 ST--NPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPPRGEAQTLPDRPLEEREPSPLTPAPQHSWRSVRIFISSTFRDMHGERDLLLRSVLPALQAQAAPHHISVRGIDLR M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 DL--NPNDVTLSGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEENTPSPLAPVSQLGWRSIRLFISSTFRDMHGERDLLLRSLLPALQARVAPYRISLHAIDLR H_sapiens_ENSP00000262715 DL--NPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLR C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 DL--NPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLASISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLR S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA DRQLEIEIVDIHFGTGSDGLTIVDLDPYVLDDHLEEIETCHCVSK---SVFLIVLLGSRLGNFLLPTKLDSSIFTAI--SKLSTDDEVQCLRKWYSTTCPKTNIHQTEDTQTLDRAEWVT A_aegypti_AAEL001276-PA DRQIEVEIVDIHFGTGS-GCTVVDLDPYVLEDHLYEIETCHRVSK---SVFLIVLLGSRLGNFLLPTKLDSEIFTAI--NKRSTADECECLRKWYQEDAAAGCYVLRTQFRTKERQEWIT M_mulatta_ENSMMUP00000021364 DL--NPNDVTLSGCTDGILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLR P_pygmaeus_ENSPPYP00000006332 DL--NPNDVTLSGCTDGILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLR O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 DRQIELEFVDMHFGTGDLEVHQLERDPYLIHDYLHEIDTCHAHTK---SVFFMVLVGDGIGRQLLPTKIDEDIFSAVLADQQTSADHEAMLVKWYERDASQTQRQLKQDYRLMNVDAWLA O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 YFLSAPAKVSIGSCSCMSLLFIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGPFVPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHAIDLR S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 FD--QCNDVVLHGFTEQVLRYVSERGTVRLLDHVAKVNERFQVPEDPDSVKRSHDFG-HEVIPSPIT----QRWRSIRIFISSTFRDMHSERNLIIGQVIPELRSRAACHYLSVEEVDLR P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 DS--NPNDVTLLGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGAPSLRPLEENTPSPLASISQSRWRKIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHAIDLR M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 NL--NPNDVTLSGCTDGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARVFPHRISLHAIDLR H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------SNGVLSVIEEEK E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------SDGVLTVSEEEK B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------SNGVLTVSEEEK P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------SDGFLTISEEEK P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------SDGFLTISEEEK H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------SDGFLTISEEEK R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------SNGVLTVVEEEK M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------RDGFLTISEKEK C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------NDGVLTISEEEK O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------SDRTLTLSEEEK M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------SDQVLSLSEEEK T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------SDEVLTLQEEER G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------ADQVLTLQEEEK A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------ADGALTPQEEAE X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------SDQVITPEEEAQ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------SDGFLTISEEEK D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------SDGVLTNDEEAK O_cuniculus_ENSOCUP00000010200 ----------------------------------------------------------------------------------------------------------------------EE T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------SDGVLSVDEEEK T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------SDGVLSIDEEDR G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------TDGVLTGDEEER O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------SDEAITVEEEDM C_elegans_Y45F10B.10 ---TINRNGAVEEYRLVPSAIKDKKQLAEIIKALQAGAKAAHEEGSINQVHEQRQNRFFSSPLETFVRSILQVSPCRCLFLLRKFDQLVADPNSPNAFLETNDQNSRKIEDLKNEITLKM C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 WGVTEEEIQKDRQLELCLGEVENSQLFVGILGSRYGYVPPNSNLPDHPHFHWVKDYPPGRSVTEMEVMQFLNRGSHQQGVSPALIYLRDSSFLSSVPDGWKIDFASESDEAAERISDLKS M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 WGITEEETRQNRQLEVCLGEVENSQLFVGILGSRYGYVPPNYSLPDHPHFCWAQQYPAGRSVTEMEVMQFLNRGLRLQPSAQPLLYFRDSSFLSSVPDAWKSDFISESEEAAHRISELKS H_sapiens_ENSP00000262715 WGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKS C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 WGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYVPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRNQCLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAACRISELKS S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA EAQQLRELLERKIDEVLRAAETKETSAGDG--------------LDGEQFCDNLKRLKTRAIAREIEKGLACSSGRILTLFRHWKNQPENDSTELEEDGHLGSNTGTEVKQVETNLIEAL A_aegypti_AAEL001276-PA ESRQLSDILENKINEILKTFPDGGEEGGGGGGSEEVVGAGGISLIDRKRFCDNLKRLKIRALELEIQKGLACSKENMLAIFRQWDAENGN-----------GPSNESRVEQIKSSLQESL M_mulatta_ENSMMUP00000021364 WGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRSQRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAACRISELKS P_pygmaeus_ENSPPYP00000006332 WGVTEEETRRNRQLEVCLGEVENAQLFVGILGSRYGYIPPSYNLPEHPHFHWAQQYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAACRISELKS O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 ESQRMQSFLEQAFQSLLQGSGASGRS---------------------PDFMERVQLLRRTQIEREVSQAMALTSEKILAVFRERAAQCSKGDVEA----------AERLRKIKDELTMNL O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 WGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYTPPSYDLPDHPHFHWTQRYPSGRSVTEMEVMQFLNRGQRSEPSDQALIYFRDPGFLSSVPDVWKPDFISESEEAAHRVSELKR S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 WGITEEETRKDRQLHLCLSEVCRSQIFIGILGERYGHVPKTYSLPLLSEYEWEGTLASNEDEEELAQEGFQERQTSLSCARRYLLYL----LFSSIPSKWVSDFGAESAEAEMKMSSLKS P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 WGVTEEETRRNRQLEVCLGEVENSELFVGILGSRYGYIPPNYNLPDHPHFRWAQQYPSGRSVTEMEVMQFLDRSLRLQPSAQALIYFRDSSFLRSVPDAWKSDFTSESEEAAHRISELKS M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 WGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGYIPPSYDLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRGQRSQPSAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKR H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 VKSQATQYQRAAALIKMILNKDNCAYISFYNALLHEGYKDLAALLQSGLPL--VSSSS-GKDTDGGITSF-------------VRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGE E_caballus_ENSECAP00000022364 VKNEPTRQQKAAMLIKMILKKDNYCYISFYKALLQEGYKDLAALLHGGIPV--LSSSN-GKDSLVGVTSY-------------VKTVLCEGGVPQRPVVFVTRKKLVHAIRQKLLKLDGE B_taurus_ENSBTAP00000028867 VKNEPTQRQRAAMLIKMILKKDNHSYISFYNALLHEGYKDLAALLHGGIPV--ISSSD-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLNGE P_troglodytes_ENSPTRP00000042795 VRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGE P_pygmaeus_ENSPPYP00000005543 VRNEPTQQQRAAMLIKMILKKDNDSYISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGE H_sapiens_ENSP00000353059 VRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGE R_norvegicus_ENSRNOP00000010869 VKSQATQYQRAAALIKMILNKDNYAYISFYNALLHEGYKDLAGLLHSGLPL--VSSSS-GKDTDGGNTSF-------------VRTVLCEGGVPQRPVIFVTRKKLVSAIQQKLWKLNGE M_mulatta_ENSMMUP00000038848 VKNEPTHHQRAAMLIKMILKKDNDSYISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGE C_familiaris_ENSCAFP00000009806 VKNEPTQQQRAALLIKTILKKDNYSYISFYNALIHEGYKDLAALLHSGIPV--ISSSNGGKDSVGGITSH-------------VKTVLCEGGVPQRPVVFVTRKKLVNAIRQNLFKLSDE O_anatinus_ENSOANP00000008896 VRNQGTQEERAAMLIKLILEKDNFSYISFYNALLHEGYRDLAALLQDGIPF--TASPK-GNDSLDGVTSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNEIQQKLYRLNDE M_domestica_ENSMODP00000009538 IRNEPTQKKRAALLITVLLGKDNNSYISFYNALLHEGYKDLAFLLQKGLPL---SSYN-GKDPVDGVTSY-------------VKTVLCEGGVPQRPVVFVTRKKLVKSIQEKLYKLNDE T_guttata_ENSTGUP00000009081 VKQQNTQKERAAMLINIILTKDNNSYRSFYNALLHEGYRDLAALLQDGIPA--VSSGN-RKSSMDGMTSY-------------VKTILCEGGVPQRPVVFVTRPKLVDAIKKKLYCLGSD G_gallus_ENSGALP00000037436 VKQQNTQKERAAMLINTLLTKDNNAYRSFYNALLHEGYRDLAALLQDGIPA--FSSKN-GKNAMDERTSY-------------VKTALCEGGVPQRPVVFVSRPKLVDDIKQKLRSLGSD A_carolinensis_ENSACAP00000012965 VKAVTTQRDRAAKLIKTILKKDDHAYISFYNALVHEGYKDLAALLQDGIPI--ISPRN-GNKSTDGVTSY-------------VKTILCEGGVPQRPVVFATRPELTKRIQRKLYKLKSD X_tropicalis_ENSXETP00000014654 VKSQRTQMDKANFLINLILGKSNQAYVSFYNALLHEGYKDLAVLLKEAANA--ELSDS-TKSSSNGITSY-------------VKTVLCEGAVPQRPVVFVTRLKLVSKIQQSLYKLSVE G_gorilla_ENSGGOP00000008216 VRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGE D_rerio_ENSDARP00000008347 VLSKATRKEQAVALLETLLRKDNRAYISFYNALIRESYGDLASLLHSDLPL--LSPEG-EKSFADGVSPS-------------VQAILSVGGVPQRPVVFVSRPPLLNLIREMLYRLRDT O_cuniculus_ENSOCUP00000010200 V-NECTQRQRAAMLIKMILKKDNNSYISFYNALLYEGYKDLAALLHGGIPV--VSGSS-GKDSVGGITSY-------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX T_rubripes_ENSTRUP00000033561 IRTLATRKDQAVALLDLLLRKDNRTYISFYNSLVKETYDDLATLLHEYLPR--LSPGA-TKNASDGCTPY-------------VQTVLSEGGVPQRPVVFVSRPELVNQIREKLYRLQKE T_nigroviridis_ENSTNIP00000013938 IRTLPTRRDQAVALLELLLKKDNRAYISFYNSLVKVAYNDLATLLFEALPR----------SASDGCTPYGNRLITSFAVCPTVQTVLSEGGVPQRPVVFVGRPELVNQIREKLYRLQKG G_aculeatus_ENSGACP00000026214 IKNQPSRKDQAAALLALLLMKDNRAYISFYNAMVQEGYNDLANLLHRDLPL--GLPEG-LKRSTDCCTPY-------------VQTVLSEGGVPQRPVVFVSRPELVNRVREKLYRLQKE O_latipes_ENSORLP00000019346 IANQNTKREQAAALVDLLLKKDNYSFRSFYNALLKEEYDELANLLKEDLPLTQFTSSS-QCPGEKCLGAV-------------VQTVLSEGGVPPRPEAFVHRPKEENEIREKLYKLQKQ C_elegans_Y45F10B.10 NDRVMTHVLRPE-STDINYFFNSRDGDKYREKIARQFNEKLKNHLADINPPVRPEPPKSPMVLA-------------------ANEARTHQEFLENQLALGNLKRDYDKRLDELASVKVN C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 YLDKQEGVTCHRYSCAWGGVAAGRPYVKGLEEFGQMVLQHVWELLQRLYVQPESSLEKTESAQNDDT----------------VQSAFQQLQHPPSPARPSLLKDIVQQLQQR------S M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 YLSRQEGITCRRYRCEWGGVAAGRPYVGGLEEFGQLVLQDVWSMIQKLYLQPGAQPEQPVPIPDDDL----------------VQATFQQLKKPRSPARPRLLQDTVRQLMQH------Q H_sapiens_ENSP00000262715 YLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSPARPRLLQDTVQRLMLP------H C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 YLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSPARPRLLQDTVQQLMLH------H S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA PASNHQTLTVD--WAENGIDPELECHDLYLTSFKNKIFEMMKASIDQDLAKDPNGGKGRKKTVQEIFHEHS------------THLMYLNEHLSANKYISSKVPERIKQNVQMNFRSGSR A_aegypti_AAEL001276-PA PAENLETLTAP--WTEGGIDPELDSHESYLNDFKELMYDKLKNAIDQSLAKDPNGGKGRKKTVQEIFYEHS------------THLMYLNEHLNASKYISSKIPDRIRQNVQQNYRSGSR M_mulatta_ENSMMUP00000021364 CLSRQKGITCRRYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNTIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSTARPRLLQDTVQQLMLH------H P_pygmaeus_ENSPPYP00000006332 YLSRQKGITCRTYPCEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSPARPRLLQDTVQQLVLH------H O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 STDNHTTLVVPGSAASEAIDPDNEDHESYLSKFKNKVTDKLRLLIEAHITNDPDVIKGRKKTVQEIFHEHA------------THLRILREHTDSDALVESRVPQQLRQNLMANFRNGSR O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 FLQEQKEVTCRRYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDL----------------IQASFQQLKSPPSPARPRLLQDTVQQLMLP------H S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 RLTEHSSAATYRYSCQWGGELQGKPHLTRLQNFGIRVLEDIWQAIERDYIKEGTLASN---EDEEEL----------------AQEGFQERQTSLSCARSKLVLSTCSQIQERTHASPTN P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 SLNRQKGITCRRYACEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPEAQLEQPVSVPDDDL----------------VQATFQQLRKPLSSARPRLLQDMVQQLMLH------R M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 YLHEQKEVTCRSYSCEWGGVAAGRPYTGGLEEFGQLVLQDVWSMIQKQHLQPGAQLEQPTSISEDDL----------------IQTSFQQLKTPTSPARPRLLQDTVQQLLLP------H H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 PGWVTIYGMAGCGKSVLAAEAVRDHSLLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCMRLDQ--EESFSQRLPLNIEEAKDRLRVLMLRKH-P--RSLLILDDVWD------------ E_caballus_ENSECAP00000022364 PGWVTIYGMAGCGKSVLAAEAVRDHTLLE-GCFPGGVHW-LSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDVWD------------ B_taurus_ENSBTAP00000028867 PGWVTIYGMAGCGKSVLAAEAVRDHSFLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCARLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDIWD------------ P_troglodytes_ENSPTRP00000042795 PGWVTIHGMAGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDVWD------------ P_pygmaeus_ENSPPYP00000005543 PGWVTIHGMAGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDVWD------------ H_sapiens_ENSP00000353059 PGWVTIHGMAGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDVWD------------ R_norvegicus_ENSRNOP00000010869 PGWVTIYGMAGCGKSVLAAEAVRDHALLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCTRLGQ--EESFSQRLPLNIEEAKDRLRVLMLRKH-P--RSLLILDDVWD------------ M_mulatta_ENSMMUP00000038848 PGWVTIHGMAGCGKSVLAAEAVRDHSLLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLPLNIEEAKDRLRILMLRKH-P--RSLLILDDVWD------------ C_familiaris_ENSCAFP00000009806 PGWVVIYGMAGCGKSVLAAEAVRDHFFLDVGCFPGGVHW-VSVGKQDKAGLLMKLQNLCTRLDQ--DENFSQRPPLNIEEAKDRLRLLMLRKH-PRIRSLLILDDIWD------------ O_anatinus_ENSOANP00000008896 PGWVTVYGMAGCGKSVLAAEALRDHRLLV-DCFPGGVHW-ISIGKQDKAGLLMKLQNLCMRFDQ--GSNFSQRPPLNIEEAKDRLRVLMLRKY-P--RSLLILDDVWD------------ M_domestica_ENSMODP00000009538 PGWVTVYGMAGCGKSVLAAEAVRDHNLLK-TCFPEGVHW-VSVGQQDKSGLLMKLQNLCTRLDQ--DGAFSQRLPLNLEEAKDRLRFLMLRKY-P--RSLLILDDIWD------------ T_guttata_ENSTGUP00000009081 PGWVTVYGMAGCGKTVLTAEALRDPQLLE-DYFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DSTLSQRPPLNIEEAKDRLRLLMLRKY-P--RSLLVLDDIWD------------ G_gallus_ENSGALP00000037436 PGWVTVYGMAGCGKTVLTAEALRDHQLLR-GCFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DSTLPQRPPLNIEEAKDRLRLLMLRKYQS--RSLLVLDDIWD------------ A_carolinensis_ENSACAP00000012965 PGWVVIYGMAGCGKTVLAADALRDHNLLK-DCFPGGVHW-VSIGKQDKSGLLIKLQNLCLRLDQ--DVTYLQRPPLNIEEAKDRLRVLLFRKY-P--RSLLVLDDIWD------------ X_tropicalis_ENSXETP00000014654 SGWVTVYGMAGCGKTVLAAEALRDHKILN-ECFPGGVHW-VSVGRQDKAGLLMKLQNLCTRLDQ--EAKYSQRPPLNAEEARERLRLMVNRMY-P--RCLIVLDDVWD------------ G_gorilla_ENSGGOP00000008216 PGWVTIHGMAGCGKSVLAAEAVRDHSLLE-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXX-X--XSLLILDDVWD------------ D_rerio_ENSDARP00000008347 PGWVTVFGMAGSGKSVMAAEVVRDRSLIK-ECFPDGVHW-LSVGQCERADLLVRMQSLCFRLEQCQSSDTSQRPPSTVEEAKERLRFLMLRRF-P--RSLLILDDVWD------------ O_cuniculus_ENSOCUP00000010200 XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XCFPGGVHW-VSVGQQDKAKLLMKLQNLCSRLDQ--DESFFQRLPLNIEEAKDRLRILMLHKH-P--RSLLILDDVWD------------ T_rubripes_ENSTRUP00000033561 PGWVTVFGMAGSGKSVLAAEAVRHHSLIE-ECFPGGIHW-LSIGQLDKPDLLVKIQALCFRLEQGLDSQSLHRPPNSLDEAKERLRYLMLRRH-P--RSLLILDDVWD------------ T_nigroviridis_ENSTNIP00000013938 SGWVTVFGMAGSGKSVLAAEAVRHHSLIE-ECFPGGINW-LSIGQLDKPDLLVKIQSLCFRLEQS-DSQSLHRPPNSLDEAKERLRHLMLRRY-P--RSLLILDDVWD------------ G_aculeatus_ENSGACP00000026214 PGWVTVFGMAGSGKSVLAAEAARHHGLIE-DCFPGGIHW-LSIGQLDKPDLLVKIQSLCFRLEQSLDSHPLHRPPNSLDEAKERLRFLMLRRH-P--RSLLILDDIWD------------ O_latipes_ENSORLP00000019346 PGWVTVFGMAGSGKSVLASEAVRHKELIE-ECFPEGIHW-VSIGRLDKPDLLAKIQTLCFRLEQNLDSQQFHRPPSTLDEAKERLRFLMIRKY-T--RTLLILDDVWD------------ C_elegans_Y45F10B.10 RGVFLIQGTDLCGKTQALCRLYHKIS----DKDAYKVIF-FTNLTYSSNFAHEAWRTICLNICSISNIDPKEVLEH------FKLGGILKSLEELVQKADKPVCIFIDDVHLL--KFGHL C_intestinalis_ENSCINP00000010464 ----AQFGVLGSARCNVE------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 GSLCLVTGEPGQGKTAFLSSLVSALQAPFGATRSSQVFFHFAGARPDQSYILTLLRRLCTYLRH--QLQHSKPFPTTYRGLVWELHT-LLPKSAQTLRSGQTLVLVIDGADQLGDQTGRL M_domestica_ENSMODP00000027702 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000004057 -EPFYKGGR--------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006840 -EPFYKGGR--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001564 GRLSLVTGQSGQGKTAFLASLVSALQAPDGATVAPLVFFHFSGARPDHSLALTLLRRLCAYLHS--QLEEPSALPSTYRGLVWELQQRLLPKSAQSLRTGQPLVLIVDGADRLVDQRGQL H_sapiens_ENSP00000262715 GRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCTYLRG--QLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQL C_intestinalis_ENSCINP00000019387 -EPFFTGGR--------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000008904 -EPFYKGGR--------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000010340 GRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRG--QLKEPGALPSTYQSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQL S_cerevisiae_YLR222C -NPIYAGSS--------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000015863 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000027147 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009615-PA -KAFYTGGT--------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000023281 ----AVFGVIGSQKANIA------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP004827-PA HPPYFIHGGHGSGKSTLLSRIYTELTGWFEHTKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIPEGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDI A_aegypti_AAEL001276-PA HPPYFIYGGHGSGKSTLLSHIYTELTGWFEHIKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIPEGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDI M_mulatta_ENSMMUP00000021364 GRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRG--QLKEPGALPNTYRSLVWELQQRLLPKSAESLHPGQTLVLIIDGADRLVDQNGQL P_pygmaeus_ENSPPYP00000006332 GRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRG--QLKEPGALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLVDQNGQL O_anatinus_ENSOANP00000004860 ----AVFGLVGSQKGNAV------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 HAPYFLCGADGSGKSAILCHLYGQVGSWFGSTRVHRVIR-FAKATPRSAYNLELLRVICQQISIIFNIPEGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLDCDI O_latipes_ENSORLP00000010395 ----AVFGVIGSQKANIA------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 GRLSLVIGQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQ--KLGEPSALPSTYRCLVWELQQKLLLKSAQWLQPGQTLVLIIDGADKLVDHNGQL S_cerevisiae_YCR057C -GTVYRQGN--------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000009169 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007980 ----AVFGVIGSQKANVA------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000010429 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035244 GRLFLVCGDRSQGKTIFMADLVKQLR----SSASTTVIYHFMGATPGAHEVEKMLTRICKQLSQ--GLNRECCNFTSYRALLSEFHD-LLRLTSHSLRRNNTLTLLIDGADLLCGRAGET P_troglodytes_ENSPTRP00000001997 ----AVFGVIGSQKGNIV------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000046830 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018405 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL004526-PA -KAFYTGGT--------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001131 ----AVFGVIGSQKGNIV------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000011166 ----AVFGVIGSQKGNIV------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ----AVFGLIGSQKGNIV------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 -EPFFKGGK--------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000013749 ----ALFGLVASARAGVA------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000015707 -EAFYKGGK--------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000009299 GRLSLVTGQSGQGKTAFLASLVSALQAPDGVKVAPLVFFHFSGARPDQGLALTLLRRLCAYLHS--QLQEPSALPSTYRGLVWHLQQRLLPKSAQSLQSGQTLVLIVDGADRLVDQHGEL M_domestica_ENSMODP00000006461 ----AVFGLIGSQKGNIV------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 GRLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLALNLLRRLCTHLRQ--KLGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQTLVLIIDGADKLVDRNGQL H_sapiens_ENSP00000308179 ----AVFGVIGSQKGNIV------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ----AVFGVIGSQKANIA------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 -EPFYKGGK--------------------------------------------------------------------------------------------------------------- 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ----PWVLKAFDNQCQILLTTRDKSVTDSVM-GPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYE E_caballus_ENSECAP00000022364 ----PWVLKAFDNQCQILLTTRDRSVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKCSSYDYE B_taurus_ENSBTAP00000028867 ----PWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIQECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYE P_troglodytes_ENSPTRP00000042795 ----SWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYE P_pygmaeus_ENSPPYP00000005543 ----SWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYE H_sapiens_ENSP00000353059 ----SWVLKAFDSQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYE R_norvegicus_ENSRNOP00000010869 ----PWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPLVVSLVGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYE M_mulatta_ENSMMUP00000038848 ----SWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYE C_familiaris_ENSCAFP00000009806 ----SWILKAFDNQCQILLTTRDKSVTDSVM-GPKYIVAVESDLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWDYYLRQLQNKQFKRIRKSSFYDYE O_anatinus_ENSOANP00000008896 ----SWVLKAFDIQCQVLLTSRDKSVTDSVMVGQKYVVPVESGLGKEKGLEILSLFVNMKKTDLPEQAHSIVQECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYE M_domestica_ENSMODP00000009538 ----SWVLKAFDSHHQILLTSRDKSVTDAMM-GPKYAVPVESGLRKEKGLEILALFVNMKKTDLPEQAHSIVKECKGSPLVVSLIGALLHDFPNRWGYYLRQLQNKQFKRIRKSSSYDYE T_guttata_ENSTGUP00000009081 ----SWVLKAFDNQCQVLITSRDRSVTDAVA-GNKYEVHVESGLAHEKGLEILSLFVNMKISELPEQANSLVRECKGSPLVISLIGALLRDFPSRWEYYLRQLQNKQFKRIRKSSSYDYE G_gallus_ENSGALP00000037436 ----SWVLKAFDNQCQVLITSRDRSVTDAVS-GNKYEIHVESGLTHEKGLEVLALFVNMKISELPEQASCIVTECKGSPLVISLIGALLRDFPSRWEYYLKQLQNKQFKRIRKSSSYDYE A_carolinensis_ENSACAP00000012965 ----SWVLKAFDSHFQILLTSRDRSVTDSVT-GKKYEVPVESGLSHEKALEILSLFVNMEITELPEKADWIVKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFRRIKKSSSYDYE X_tropicalis_ENSXETP00000014654 ----SWVLKAFDIQCRVLITSRDKSVTDSLP-GFKEAVHVDSELEHSKGLEILSRFLNIKAEALPSQAHNIIKVSKGSPLVVSLIGALLREFPTRWDFYLTQLKRKQFKRIRKSSSYDYE G_gorilla_ENSGGOP00000008216 ----SWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX D_rerio_ENSDARP00000008347 ----SSSLRSFDIQCRVLLTTRNRALTDSVS-GVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSLIGALLREFPDRWSYYLRQLQQKQFKRIRKSSSYDYE O_cuniculus_ENSOCUP00000010200 ----PWVLKAFDNQCQILLTTRDKSVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKTDLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYE T_rubripes_ENSTRUP00000033561 ----SMVLKTFDIHARILLTTRNRSLTDSVG-GAKYEVEVESGLDEKKGLEILALYTDNKPHGLPEEARSIVRECKGSPLVMSLIGALLKEKPNRWCYYLRQLQQKQFKRIRKSSSYDYD T_nigroviridis_ENSTNIP00000013938 ----ITVLKTFDIHCRILLTTRNRSLTDSVG-GNKYEVEVESGLDENKGLEILALYTDNKPHGLPEEACSIVRECKGSPLVVSLIGALLKEKPNRWSYYLRQLQQKQFKRIRKSSSYDYD G_aculeatus_ENSGACP00000026214 ----STVLKAFDLHCRILFTTRNRSLADSVS-GSRYEVEVESGLDENKGLEILALYTKTKLKGLPEEARSIVRECKGSPLVVSLIGALLREKPNRWRYYLGQLQQKQFKRIRKSSSYDYD O_latipes_ENSORLP00000019346 ----STVLKAVDIHCRILLTTRNRSLADVVN-GSKHEVEVNSGLDEDKALEILSQLSKIEMYRLPEEALSIVKKCQGSPLAVSMIGSLLRENPDRWGYYLRQLEKKQFRRIRKSSSYNYE C_elegans_Y45F10B.10 LSQIGRRTETAPDNLSLFMTSSNVAPVNAVF-------------AVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISAIRPLMAAKDGILIAKSFTHEI---------------LF C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 IS--DWIPKSLPQKVHLVMSMSTSTGLADIL----------QCRRDAHVVALRSLEPTARAQLVRQELALYGKRLEETPFNNQMRLLLVKRGAALPLYLRLATDHLRLFTLFEQMSEQLR M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 IS--DWIPKILPRWVHLVLSVSSDSGLGETL----------EQRQGAHVVALGPLEPSARAQLVREELALYGKRLEESPFNNQMRLLLVKRGSVLPLYLRLVTDHLRLFTLYEQVSERLQ H_sapiens_ENSP00000262715 IS--DWIPKKLPRCVHLVLSVSSDAGLGETL----------EQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLR C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 IS--DWIPKKLPRCVHLVLSVSSDAGLGETL----------EQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLR S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA VAALSWLPISLPWNVFLVVSTTVP-----------------------------------------------IESLRLTPMQKERFKCADYFFDLSLEQNETKIKHWGVVPSCTEAPPDEL A_aegypti_AAEL001276-PA VAALSWLPISLPWNVFLVVSTTVP-----------------------------------------------IDSLKLTPMQKERFKYSDYFFDLSLEQNETIVRK-----------VDSS M_mulatta_ENSMMUP00000021364 IS--DWIPKKLPRCVHLVLSVSRDAGLGETL----------EQSQGAHVVALGPLEASARARLVREELALYGKRLEESPFNNQVGKLWFLIMSPSPLPLALPVSMSRSVLLTFQVSERLR P_pygmaeus_ENSPPYP00000006332 IS--DWIPKKLPRRVHLVLSVSSDAGLGETL----------EQSQGAHVVALGPLEASARARLVREELALYGKRLEESPFNNQMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLR O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 VTALSWLPTSLPWNVQIICSSTTP-----------------------------------------------VEQLKFTPMQRDRFKSIEYQFDLNMGDYATKLK----------IPPQCI O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 IS--DWIPKSLPRRVHLVLSVSSDSGLGETL----------QQSQSAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLR S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 TS--EWIPEHLPQRINLVLSVTEGSSLGYSL----------ARQKDTVSISLTSLQPSDRAELVRHWLAVYGKKLEESAFNNQMRLLLIKKGTKHPLYLTMACEELRATAVFERLSDDIE P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 IS--DWIPKTLPRWVHLVLSMSTDAGLGESL----------EQSQGAHVVALGPLEPSARARLVREELALYGKRLEESPFNNQMRLLLVKRGSALPLYLRLVTDHLRLFTLYEQVSERLR M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 IS--DWIPKSLPRRVHLVLSVSSDSGLGETL----------QQSQGAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNNQMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLR H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEF--------VNKSLLFCNRNGK----------SFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQF E_caballus_ENSECAP00000022364 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLTEKNRSQLQDLHRKIITQF B_taurus_ENSBTAP00000028867 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDLETEEVEDILQEF--------VNKSLLFCDRNGK----------SFLYYLHDLQVDFLAEKNRSQLQDLHKKMVTQF P_troglodytes_ENSPTRP00000042795 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQF P_pygmaeus_ENSPPYP00000005543 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQF H_sapiens_ENSP00000353059 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQF R_norvegicus_ENSRNOP00000010869 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWDLETEEVEDILQEF--------VNKSLLFCNRNGK----------SFCYYLHDLQVDFLTEKNRSQLQDLHRKMVTQF M_mulatta_ENSMMUP00000038848 ALDEAMSISVEMLREDIKYYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQF C_familiaris_ENSCAFP00000009806 ALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFRYYLHDLQVDFLIEKNRNQLQDLHKKIVTQF O_anatinus_ENSOANP00000008896 ALDEAMSISVEMLTEEFKDYYKDLSVLQKDVKVPTKVICILWEMETEEVEDILQEF--------VNKSLLFCDRNGK----------TFHYYLHDLQVDFLTEKNRSQLQELHKKIVNQY M_domestica_ENSMODP00000009538 ALDEAMSISVERLSEDLQKYYKDLSILQKDVRVPTKVLCILWDMETEEVEDILQEF--------INKSLLFYDRNGK----------SFRYYLHDLQVDFLMEKNRDQLKELHRKVVTQF T_guttata_ENSTGUP00000009081 ALDEAMSISVEQLDDNYKDYYKDLSILPKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFHYYLHDLQLDFLTEKNRNQLQELHKNIVNQY G_gallus_ENSGALP00000037436 ALDEAMSISVEQLSNDLKEYYKDLSILPKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGN----------SFHYYLHDLQLDFLTEKNCNQLQELHKNIVNQY A_carolinensis_ENSACAP00000012965 ALDEAMSISVEMLPENSKDYYRDLSVLQKDVKVPSKVFCVLWDIETEEAEDILQGF--------VNKSLLFCDRNGK----------SFHYYLHDLQLDFLTEKNRDQLQALHKKVVHQY X_tropicalis_ENSXETP00000014654 ALDEAMSISVDNLKEDFKEYYNDFSIIEKDVKVPTQVLCILWDMEREDVEDMMQEF--------VNKSLVYCDRNGK----------SYSYYLHDLQLDYLTERNRDRLTVLHSKLVDQY G_gorilla_ENSGGOP00000008216 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--------XXXXXXXXXXXXX----------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX D_rerio_ENSDARP00000008347 ALDQAMDASLQVLEAEHQELYRDLSVMQKDIKVPAKVLSVLWGLELEEVEDVLQEF--------VNKSLLFRDCNQR----------PYRYYLHDLQLDFLAEQNRDQIAELHKKMVRQY O_cuniculus_ENSOCUP00000010200 ALDEAMSISVDVLREDIRDYYTDLSIFQKDVKVPTKVLCILWDMETEEVEDILQEF--------VNKSLLFCDRNGK----------SFSYYLHDLQVDFLTEKNRSQLQXXXXXXXXXX T_rubripes_ENSTRUP00000033561 ALDQAMAASIEVLPPEHQELYKDLTVLEKDIKIPAKVLSVLWVLEPEEVEDILEEF--------VNKSLLYVDINHK----------PYLYYLHDLQLDFLVEQNQAQLERLHTKVVQQY T_nigroviridis_ENSTNIP00000013938 ALDQAMAASIEVLPDEHQELYKDLTVFEKDIKIPAKVLSVLWDLEPEDVEDILEEF--------VNKSLLFVDSNHR----------PYLYYLHDLQLDFLVEQNRTQLERLHTKVVQQY G_aculeatus_ENSGACP00000026214 ALDQAMAASIEVLPDEHREFYKDLTVLEKDTKVPAKVLAVLWDLETEEVEDILEEF--------VNKSLLFVDSHNK----------PFLYYLHDLQLDFLVEQNRTQLESLHSKVVHQY O_latipes_ENSORLP00000019346 ALDQAIAAGIEDLSDDYRDLYNLLTVLHKDVKVTAKMMSVLWGQDQVDTEDTLSEF--------VNRAMLFVDSQSQ----------PNVFYLHDLQLDFLLEQNKNQLKVLHKKMVERY C_elegans_Y45F10B.10 NGNSSMKGGMDGRMTRIEKEFGKLAVGNAV----KFIAASSHGLTRLEIHDAI-----------SADREVLEEMNMSIVYSLLTLDGIIEALGPILRK--VIIDDRQIIGIAHSGLISWL C_intestinalis_ENSCINP00000010464 --------------------YLSMR-NTQG----RYVAAA------------------------ACENVCVWDMRTL------------------------------------------- M_domestica_ENSMODP00000008927 TLPATVPLLLQHVLGVLEQEHEPDILPLAL----AALQVTRSGLTVDRLHGVISTWRALS-SETVDWAEAMAARNKGDPYPMGPFTYLIQSLRRLLGEG-SLELPGARLRLPPGPLSSAV M_domestica_ENSMODP00000027702 -----------------------VQASQDG----QLLFCV------------------------CGSGVNVVDATSG------------------------------------------- T_nigroviridis_ENSTNIP00000004057 -----------------------VQISKDE----NYIFCT------------------------CGSRVNVLEISTG------------------------------------------- T_guttata_ENSTGUP00000006840 -----------------------IQISRDG----KFMFCP------------------------CGSKVNVVDVETG------------------------------------------- B_taurus_ENSBTAP00000001564 TLPATVPLLLQHVLGTLEQEHGPDVLPQAL----ATLEATRSGLTVDQLHGVLSAWRILP-RGSKSWEEAVAAGNSGDPYPMGQFAYLVQSLRSLLGEG-PLERPGARLCLQDGPLRTAA H_sapiens_ENSP00000262715 TLPATVPLLLQHILSTLEKEHGPDVLPQAL----TALEVTRSGLTVDQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGEG-PLERPGARLCLPDGPLRTAA C_intestinalis_ENSCINP00000019387 -----------------------VEVSNSE----NYLLCV------------------------CGDKIKIVNVDSG------------------------------------------- G_gallus_ENSGALP00000008904 -----------------------VQVSRDG----KFMFCP------------------------CGTKLNVIDVETG------------------------------------------- P_troglodytes_ENSPTRP00000010340 TLPATVPLLLQHILSTLEKEHGPDVLPQAL----TALEVTRSGLTVDQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLL-EG-PLERPGARLCLPDGPLRTAA S_cerevisiae_YLR222C ---------------------AVATVSENG----KILATP------------------------VLDEINIIDLTPG------------------------------------------- G_aculeatus_ENSGACP00000015863 -----------------------VQISKDE----KYIFCT------------------------CESRVNVLEISTG------------------------------------------- B_taurus_ENSBTAP00000027147 -----------------------VQLDQTG----QHLFCV------------------------CGTRVNILDVASG------------------------------------------- A_gambiae_AGAP009615-PA -----------------------IVWKPDA----QQFLCL------------------------NNGTISIVSVDN-------------------------------------------- D_rerio_ENSDARP00000023281 --------------------FVTLRGGEKG----RYVAVG------------------------ACEHVFIWDVRKA------------------------------------------- T_rubripes_ENSTRUP00000017221 -----------------------VQISKDE----NYIFCT------------------------CGSRINVLEISTG------------------------------------------- A_gambiae_AGAP004827-PA P---TFAQLVNGLFDAMEQQFGVKGFSRLA----IYITCSEYGLTETELLELLMP---------TQDADLVIKSNEG-DFNFSTFRTIRNQMK--LILREKLMSGKLLIVWRHSICAEIT A_aegypti_AAEL001276-PA Q---SFEEYVNNIFNAMEKRFGRKGFSKLA----IYITCSEYGLTETEFLELLMP---------TQDSDALIDTNEG-GFNFSTFRTARNEMR--ALLREKLMSGKLLIVWRHSICSEIT M_mulatta_ENSMMUP00000021364 TLPATVPLLLQHILSTLEQEHGPDVLPQAL----TALEVTRSGLTVDQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLLGEG-PLERPGARLCLPDGPLRTAA P_pygmaeus_ENSPPYP00000006332 TLPATVPLLLQHVLSTLEKEHGPDVLPQAL----TALEVTRSGLTVDQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLLGEG-PLERPGARLCLPDGPLRTAA O_anatinus_ENSOANP00000004860 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDPRKG------------------------------------------- D_melanogaster_FBpp0085899 PGDVSFALYVEQQFDQLERHYGRQAVGDLA----SYITCSEYGLSETELLELLMP---------TDDPESLIETKNG-HFSFATFKKIHREMDLLLLLHDKIMSGKVLIQWRHNYCASVA O_latipes_ENSORLP00000010395 --------------------YVTLRGGERG----RYVAVA------------------------ACEHVFVWDVRKG------------------------------------------- R_norvegicus_ENSRNOP00000012235 TLPATLPLLLQHILSTLEQEHGHNVLPQAL----TALEVTHSGLTVDQLHAVLSTWLTLP-KETKSWEEAVAASHSGNLYPLAPFAYLVQSLRSLLGEG-PVERPGARLCLSDGPLRTAV S_cerevisiae_YCR057C -----------------------ITFSDDG----KQLLSP------------------------VGNRVSVFDLINN------------------------------------------- G_gorilla_ENSGGOP00000009169 -----------------------AQLDQTG----QHLFCV------------------------CGTRVNILEVASG------------------------------------------- T_nigroviridis_ENSTNIP00000007980 --------------------YVTLRGGEKG----RYVAAA------------------------ACEHVFIWDVRKG------------------------------------------- H_sapiens_ENSP00000331815 -----------------------AQLDQTG----QHLFCV------------------------CGTRVNILEVASG------------------------------------------- M_mulatta_ENSMMUP00000010429 -----------------------AQLDQTG----QHLFCI------------------------CGTRVNILEVASG------------------------------------------- X_tropicalis_ENSXETP00000035244 KLPATLPALIQRRLESLEQEHGVTTVSIAL----AVICLSRKGLPERDLLRILSSLQALNCVFTAKWNAMLAAFAGAQNLPMATFALLLRGVRSVLGLWLPALTSDHRLHLPSCLLRDAV P_troglodytes_ENSPTRP00000001997 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDLRKG------------------------------------------- P_pygmaeus_ENSPPYP00000007898 -----------------------AQLDQTG----QHLFCV------------------------CGTRVNILEVASG------------------------------------------- M_musculus_ENSMUSP00000046830 -----------------------AQLDQTG----HYLFCV------------------------CGTKVNILDVASG------------------------------------------- R_norvegicus_ENSRNOP00000018405 -----------------------AQLDQTG----RHLFCV------------------------CGTKVNILDVASG------------------------------------------- A_aegypti_AAEL004526-PA -----------------------VQWTSDG----SEMLCQ------------------------NAGAINLVSVTDD------------------------------------------- P_pygmaeus_ENSPPYP00000001131 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDLRKG------------------------------------------- P_troglodytes_ENSPTRP00000053800 -----------------------AQLDQTG----QHLFCV------------------------CGTRVNILEVASG------------------------------------------- M_mulatta_ENSMMUP00000011166 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDLRKG------------------------------------------- R_norvegicus_ENSRNOP00000026726 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDLRKG------------------------------------------- O_anatinus_ENSOANP00000015573 -----------------------IQISSDG----QHMFCV------------------------CGSKLNVLDVATG------------------------------------------- T_guttata_ENSTGUP00000013749 --------------------FVALR-GERG----RYVAVP------------------------ACEHVFVWDTRKG------------------------------------------- C_familiaris_ENSCAFP00000028736 -----------------------VQLDQTG----QHVFCV------------------------CGTKVNVLDVASG------------------------------------------- X_tropicalis_ENSXETP00000015707 -----------------------VQINSDG----TYILCT------------------------CGNKLNILDIATG------------------------------------------- E_caballus_ENSECAP00000009299 TLPATVPLLLQHILGTLEQEHGPSVLPQAL----ATLEVTRSGLTVDQLHGVLSAWRILP-MGTKTWEEAVAAGDSGDPYPMGPFAFLVQSLRSLLGEG-PLERPGARLCLRDGPLRTAA M_domestica_ENSMODP00000006461 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDIRKG------------------------------------------- M_musculus_ENSMUSP00000006444 TLPATLPLLLQHILSTLEQEHGHDVLPQAL----TALEVTRSGLTVDQLHAILSTWLILP-KETKSWEEVLAASHSGNPFPLCPFAYLVQSLRSLLGEG-PVERPGARLCLSDGPLRTTI H_sapiens_ENSP00000308179 --------------------FVTLR-GEKG----RYVAVP------------------------ACEHVFIWDLRKG------------------------------------------- T_rubripes_ENSTRUP00000006345 --------------------YVTLRGGEKG----RYIAAA------------------------ACEHVFIWDVRKG------------------------------------------- E_caballus_ENSECAP00000017445 -----------------------VQLDQTG----QHLFCV------------------------CGTRVNILDVASG------------------------------------------- 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 QRYYQPHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASANMHKELCAL-MFSL E_caballus_ENSECAP00000022364 QRHHRLHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASANMHKELCAL-MFSL B_taurus_ENSBTAP00000028867 QRHHQLYSLSPDQEDCMYWYSF----------------------------------------------------------------------------LAYHMASANMHKELCAL-MFSL P_troglodytes_ENSPTRP00000042795 QRYHQPHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAKMHKELCAL-MFSL P_pygmaeus_ENSPPYP00000005543 QRYHQSHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAKMHKELCAL-MFSL H_sapiens_ENSP00000353059 QRYHQPHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAKMHKELCAL-MFSL R_norvegicus_ENSRNOP00000010869 QRYHQPHTLSPGQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAGMHKELCAL-MFSL M_mulatta_ENSMMUP00000038848 QRYHQPHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAKMHKELCAL-MFSL C_familiaris_ENSCAFP00000009806 QKHYQPHTLSPDQEDCMYWYNF----------------------------------------------------------------------------LAYHMASASMHKELCAL-MFSL O_anatinus_ENSOANP00000008896 QKYYQLRTLSPDQDDCMYWYNF----------------------------------------------------------------------------LAYHMASANMHKELCAL-MFSL M_domestica_ENSMODP00000009538 QRYCQAHSLPSDQEDSMYWYNF----------------------------------------------------------------------------LAYHMASADMRQELCNL-MFSL T_guttata_ENSTGUP00000009081 KKYYKLNTPVLSQEDCMYWYNF----------------------------------------------------------------------------LAYHMAGAKMQQELRDL-MFSL G_gallus_ENSGALP00000037436 KRYYKLHVPVLSQEDCMYWYNF----------------------------------------------------------------------------LAYHMAGANMQKELRDL-MFSL A_carolinensis_ENSACAP00000012965 KNHYAQYMPNSTQEDWMYWYNF----------------------------------------------------------------------------LAYHMSSASMHDELCAL-MFSL X_tropicalis_ENSXETP00000014654 KKHYSSKSPAVDQEDSVYWYHY----------------------------------------------------------------------------LAYHMAKANMHQDLCSL-LFSL G_gorilla_ENSGGOP00000008216 XXXXXXXXXXXXQEDCMYWYNF----------------------------------------------------------------------------LAYHMASAKMHKELCAL-MFSL D_rerio_ENSDARP00000008347 QRFYSKRPPDSADKDSLYWYQF----------------------------------------------------------------------------IPYHMAKAGLSKELYSL-MFSL O_cuniculus_ENSOCUP00000010200 XXXXXXXXXXXXXXXXXXXXXX----------------------------------------------------------------------------XXXXXXXXXXXXELCAL-MFSL T_rubripes_ENSTRUP00000033561 QLHYKGDPPLSGDEECLYWIRF----------------------------------------------------------------------------LTLHMAKAGLSQELYSL-MFSL T_nigroviridis_ENSTNIP00000013938 QLHYKDGPPLSGDEECLYWVRF----------------------------------------------------------------------------MTYHMAKAKLSQELYSL-MFSL G_aculeatus_ENSGACP00000026214 QQHYKDAHSTSGDEECLYWIRF----------------------------------------------------------------------------LTYHMAKANLFQELYSL-MFSL O_latipes_ENSORLP00000019346 QHRYKDRPLTSRDEESLYWIRY----------------------------------------------------------------------------LAYHMANANLFQELHSL-LFSL C_elegans_Y45F10B.10 RNRYLTSSQDIRSAHLQLSDLFADLLIDNEQ--------------------------------------SPRHEIAYQSFSQGIKRDNGSPNFRRLRLLWYHCLHSGNLDRLKELSLCHF C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 ELRYRKRPGLKTKAHVLIAVQLWKMCDPEAL------------------------------------------------------GTFHNCHPEALNDLPYHLVQSGNHSLLASL-LTNL M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 RCRYGKRPELEKTAHLLTAAQLWKTCDPDAS------------------------------------------------------GTFRRCPPEALADLPYHLLQSGNRGLLAKF-LTSL H_sapiens_ENSP00000262715 KRCYGKRPGLEDTAHILIAAQLWKTCDADAS------------------------------------------------------GTFRSCPPEALGDLPYHLLQSGNRGLLSKF-LTNL C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 KRRYGKRPGLEDTAHILIAAQLWKTCDADAS------------------------------------------------------GTFRSCPPEALGDLPYHLLQSGNRGLLSKF-LTNL S_cerevisiae_YLR222C ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004827-PA RVRYMT-PDITRSIHSELVNLFFPPDGDDSE-DMSTEQHSRKSMHCFTN-EKETKNTALLTAISETERDHCRHRIDDNVTQVLNLGPDISYSIRHVEEAWHHLIKSEDTKKLKEIAVCNF A_aegypti_AAEL001276-PA KVRYMT-PDISRSVHSEIVNLFFPPDSEESD-EISSAQNSRKSSHYKKRVLREGDSLGVISMCRKGGKIRIQTQHDDNVTQIITLGPDISYSIRHVEESWHHLIKSDDTKKLKEIAVCNF M_mulatta_ENSMMUP00000021364 KRRYGKRPGQEDTAHILIAAQLWKTCDADAS------------------------------------------------------GTFRSCPPEALVDLPYHLLQSGNRGLLSKF-LTNI P_pygmaeus_ENSPPYP00000006332 KRRYGKRPGLEDTAHILIAAQLWKTCDADAS------------------------------------------------------GTFRSCPPEALGDLPYHLLQSGNRGLLSKF-LTNL O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0085899 KRRYMD-VQRTRSLHCELANLFFPQDEDESTLENESNRSESKSVISLKDRDREKDSLSAVSAVSAGRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNF O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 KRRYGKRLGLEKTAHVLIAAHLWKMCDPDAS------------------------------------------------------GTFRSCPPEALKDLPYHLLQSGNHGLLAKF-LTNL S_cerevisiae_YCR057C ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 EKRYLMKRDVTKAAHLLMAAHFWTVCSPEDP------------------------------------------------------DSVPVINAECLSELSHHLLCSEQLHTLGWL-LTHL P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 KSRYGRRPGLEKTAHILIAAQLWKACDPDAS------------------------------------------------------GTFRSCPPEALGDLPYHLLQSENYGLLTKF-LTNL M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 KRRYGKRLGLEKTAHVLIAAHLWKTCDPDAS------------------------------------------------------GTFRSCPPEALKDLPYHLLQSGNHGLLAEF-LTNL H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 DWIKAKTELVGPAHLIHEFVAYRHILDEKDCAVCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYRQAKLQAK-QEGDTGRLYLEWINKKTIKNLSRLVV E_caballus_ENSECAP00000022364 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCSVCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWINKKNIKNLSRLVV B_taurus_ENSBTAP00000028867 DWIKAKTELVGPAHLIHEFVEYRHILDEKDGIDCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCELETSEVYRQAKLQAK-QEVDNGMLYLEWVNKKNMKNLSRLVV P_troglodytes_ENSPTRP00000042795 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWINKKNITNLSRLVV P_pygmaeus_ENSPPYP00000005543 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWINKKNITNLSRLVV H_sapiens_ENSP00000353059 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWINKKNITNLSRLVV R_norvegicus_ENSRNOP00000010869 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDTGRLYLEWINKKTIKNLSRLVV M_mulatta_ENSMMUP00000038848 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSEN----FQEFLSLNGHLLERQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWINKKNITNLSRLVV C_familiaris_ENSCAFP00000009806 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDHGMLYLEWINKKNIKNLSRLVV O_anatinus_ENSOANP00000008896 DWIKSKTELVGPAHLIHEFAEYSHILDEKDCTVCEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYRQAKLRAK-QEVDKGMLYLEWINKKNIKNLSRLVV M_domestica_ENSMODP00000009538 DWIKAKTELVGPAHLIHEFMRYRHLLDKKDCTICEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYRQAKLRAK-QEVDKGKLYLEWINKKTIKKLSRLVV T_guttata_ENSTGUP00000009081 DWIKAKTELVGPAHLIHEYVEYSSVLDQKDSTVREN----FQEFLSLNGHLLGRQPFPDIIQL-----------GLCQPETSEVYQQAKLHAQ-RE--TGTFYLEWINKKSLKNLYRLVV G_gallus_ENSGALP00000037436 DWIKAKTELVGPAHLIHEYVEYSSVLDEKDSIIREN----FQEFLSLNGHLLGRQPFPDITQL-----------GLCQPETSEVYQQAKLRAQ-RE--TGTFYLEWINKKSLKNLSRLVV A_carolinensis_ENSACAP00000012965 EWIKTKTELVGPAHLIHEYVEYSEILNEKDPIAREN----FQEFLSLNGHLLGRQPSLDIVQL-----------GLCQPESSKVYQQAKLQAQ-QGLDKGSFYVEWMNKQSIKNTYRLVV X_tropicalis_ENSXETP00000014654 NWLKAKTELFGTAHLIHEFVQYRNILDNQNAKAREH----FQEFIAVNGHLLGSNPDVSIVQL-----------GLGQAEDSEVYKQAILQAK-EELQSGALYVNWINKQSIKNLPTLVV G_gorilla_ENSGGOP00000008216 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSEN----FQEFLSLNGHLLGRQPFPNIVQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWXXXXXXXXXXXXXX D_rerio_ENSDARP00000008347 DWVKEKARIMGSAHLINDYVEYGEILDKENSEVRVQ----FQEFLSLNGHHLEQRPFPDVVQL-----------ALSQPDRSEVYRQALMQAQ-KRASRGQIYLNWVNKNIEEGLSRLVM O_cuniculus_ENSOCUP00000010200 DWIKAKTELVGPAHLIHEFVEYRHILDEKDCTVCEN----FQEFLSLNGHLLGRQPFPNIIQL-----------GLCEPETSEVYQQAKLQAK-QEVDNGMLYLEWI-KKNIKNLSRLLV T_rubripes_ENSTRUP00000033561 DWVSIKARIMGPAHLISDYVEYGHILDKKNSDVRSQ----FQEFLSLNGHHLEQRPFPDVVQL-----------ALSQPHASDVYRQALQEAQ-EQASTGKLYFDWLNKNSMESLSHLVI T_nigroviridis_ENSTNIP00000013938 DWVSIKAQIMGPAHLISDYVEYGHILDKENSDVRSQ----FQEFLSLNGHQLEQRPFPDVVQL-----------ALSQPHASEVYRQALQQAQ-ERASTGKLYFDWLNKNSVESLSRLVI G_aculeatus_ENSGACP00000026214 DWVSTKAQLMGPAYLINDYVEYGPILDKENSETRSQ----FQEFLSLNGHHLEQRPFPDVVQL-----------ALSQPRTSEVYKQALLQAR-DRATTGKLYFEWLNKGSVESLSRLVI O_latipes_ENSORLP00000019346 DWISVKGQIMGPAHLINDYLEYGSILDKENNEMCSE----FQEFLSLSGHYLEQRPFPDIVQL-----------ALSQPHTSEVYRQARLLAQ-ERAKDGKLYFDLINETSVDSLSRLVI C_elegans_Y45F10B.10 EYVDYVTRYFGISHLLSLYEECATQILHHDLQVISE------QVLVPALVTMARDSEQLAAEVIGRLRFTRH--ENSHFLNSLVDQAMSWVDLYNRQPLLVPLTCWISPPATKVCRSFTL C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------------------------------------------------QLVLLL M_domestica_ENSMODP00000008927 NVTATYLELGLLSQLGEAHALYASSVPMSEPVSSETDVIAFHTFLKQQSRLLTQYPALLTQQ------------ATNQPSNSPIYQQVPKLAQ---RWSSQPILRWLNKPQTMGSQQ--- M_domestica_ENSMODP00000027702 ----------------------------------------------------------------------------------------------------------------NLVRTF-- T_nigroviridis_ENSTNIP00000004057 ----------------------------------------------------------------------------------------------------------------KIVHSV-- T_guttata_ENSTGUP00000006840 ----------------------------------------------------------------------------------------------------------------ALLHSL-- B_taurus_ENSBTAP00000001564 HVVAAHLELGLTSQLLEAHALYASSVPGEEQKLPEADVAAFHTFLRQQAPILSRYPLLLHQQ------------VANQPLDSPLCRQAPRLSQ---RQHLQCMLHWLNKPQTLKHQQ--- H_sapiens_ENSP00000262715 HVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQYPRLLPQQ------------AANQPLDSPLCHQASLLSR---RWHLQHTLRWLNKPRTMKNQQ--- C_intestinalis_ENSCINP00000019387 ----------------------------------------------------------------------------------------------------------------LVEKEL-- G_gallus_ENSGALP00000008904 ----------------------------------------------------------------------------------------------------------------ALLHSL-- P_troglodytes_ENSPTRP00000010340 HVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFHTFLRQQASILSQYPRLLPQQ------------AANQPLDSPLCHQAPLLSQ---RWHLQHTLRWLNKPQTMKNQQ--- S_cerevisiae_YLR222C --------------------------------------------------------------------------------------------------------------SRKILHKI-- G_aculeatus_ENSGACP00000015863 ----------------------------------------------------------------------------------------------------------------KIVHSV-- B_taurus_ENSBTAP00000027147 ----------------------------------------------------------------------------------------------------------------AVLRSL-- A_gambiae_AGAP009615-PA ----------------------------------------------------------------------------------------------------------------LHEPVALG D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------------------------------------------------EKVLIL T_rubripes_ENSTRUP00000017221 ----------------------------------------------------------------------------------------------------------------KIVHSV-- A_gambiae_AGAP004827-PA DFLLAAVQTVSISYL-------RCLIEHVRCYILDRDIELVYYTIRKSSDVLTRDPMQLGAQLISWLKSVSAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLPVPLPSQIRCITV A_aegypti_AAEL001276-PA DFLLAAVQTVSISYL-------RCLIEHVRCYILDRDIELVYYTIRKSSDVLTRDPMQLGAQLISWLKSVAAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLPVPLPSQIRCMTV M_mulatta_ENSMMUP00000021364 HVVAAHLELGLVSRLLETHALYASSVPKEEQKLPEADVTVFRTFLRQQASILSQYPQLLPQQ------------AANQPLDSPLCQQAPLLSQ---RWHLQHTLRWLNKPQTMKNQQ--- P_pygmaeus_ENSPPYP00000006332 HVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQASILSQYPRLLPQQ------------AANQPLDSPLCHQAPLLSQ---RWHLQHTLRWLNKPQTMNNQQ--- O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------------------------------------------------EKILIL D_melanogaster_FBpp0085899 DFLLAAVQTVSISYL-------RCLIEHVRCYILDRDIELIYYTIRKSSDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWLPAPLPSQIRTMTV O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------------------------------------------------EKVLIL R_norvegicus_ENSRNOP00000012235 HVVAAYLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFHNFLKQQASLLTQYPLLLLQQ------------AASQPEESPVCCQAPLLTQ---RWHNQCILKWINKPQTLKGQQ--- S_cerevisiae_YCR057C -------------------------------------------------------------------------------------------------------------------KSFTF G_gorilla_ENSGGOP00000009169 ----------------------------------------------------------------------------------------------------------------AVLRSL-- T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------------------------------------------------EKVMIL H_sapiens_ENSP00000331815 ----------------------------------------------------------------------------------------------------------------AVLRSL-- M_mulatta_ENSMMUP00000010429 ----------------------------------------------------------------------------------------------------------------VVLRSL-- X_tropicalis_ENSXETP00000035244 PFLRVHAALGLLPHLCQVYSMYDCTIHELDRQVSKLPVDVFREFIHNSLPVLSKNPSLFYQQ------------ALNEPDCSPVCFQARVIIDNRKECTSHLTMLWNNKPAYMSICRSLF P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------------------------------------------------EKILIL P_pygmaeus_ENSPPYP00000007898 ----------------------------------------------------------------------------------------------------------------TVLRSL-- M_musculus_ENSMUSP00000046830 ----------------------------------------------------------------------------------------------------------------ALLRSL-- R_norvegicus_ENSRNOP00000018405 ----------------------------------------------------------------------------------------------------------------DLIRSL-- A_aegypti_AAEL004526-PA ----------------------------------------------------------------------------------------------------------------TVEPVIFG P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------------------------------------------------EKILIL P_troglodytes_ENSPTRP00000053800 ----------------------------------------------------------------------------------------------------------------AVLRSL-- M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------------------------------------------------EKILIL R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------------------------------------------------EKILIL O_anatinus_ENSOANP00000015573 ----------------------------------------------------------------------------------------------------------------ALEQRL-- T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------------------------------------------------EKVLIL C_familiaris_ENSCAFP00000028736 ----------------------------------------------------------------------------------------------------------------AVLRSL-- X_tropicalis_ENSXETP00000015707 ----------------------------------------------------------------------------------------------------------------AVTYTI-- E_caballus_ENSECAP00000009299 HVMAAHLELGLISRLLEAHALYASSIPEEGQKLPEADVAVFHTFLRQQAPVLSQYPLLLPQQ------------AANQPLDSPLCLQAPQLSQ---RWHLQRMLRWLNKPQTTRGQQ--- M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------------------------------------------------EKILIL M_musculus_ENSMUSP00000006444 HVVAAYLEVGLVPDLLEAHVLYASSKPEANQKLPAADVAVFHTFLRQQASLLTQYPLLLLQQ------------AASQPEESPVCCQAPLLTQ---RWHDQFTLKWINKPQTLKGQQ--- H_sapiens_ENSP00000308179 ------------------------------------------------------------------------------------------------------------------EKILIL T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------------------------------------------------EKVMIL E_caballus_ENSECAP00000017445 ----------------------------------------------------------------------------------------------------------------AVLRSL-- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 RP------HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE-TGEKLLDIKA-HEDEVLCCAFSS--DDSYIATCSADKKVKIWDSATGKL--------VHTYDE-HSEQVNCCHFTN E_caballus_ENSECAP00000022364 RP------HTDAVYHACFSGDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGEL--------VHTYDE-HSEQVNCCHFTN B_taurus_ENSBTAP00000028867 RP------HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFSA--DDKFIATCSVDKKVKIWNSMTGEL--------VRIYDE-HSEQVNCCHFTN P_troglodytes_ENSPTRP00000042795 RP------HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGEL--------VHTYDE-HSEQVNCCHFTN P_pygmaeus_ENSPPYP00000005543 RP------HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGEL--------VHTYDE-HSEQVNCCHFTN H_sapiens_ENSP00000353059 RP------HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGEL--------VHTYDE-HSEQVNCCHFTN R_norvegicus_ENSRNOP00000010869 RP------HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE-TGEKLLDIKA-HEDEVLCCAFSS--DDSYIATCSVDKKVKIWDSGTGKL--------VHTYEE-HSEQVNCCHFTN M_mulatta_ENSMMUP00000038848 RP------HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSVTGEL--------VHTYDE-HSEQVNCCHFTN C_familiaris_ENSCAFP00000009806 RP------HTDAVYHACFSEDGQRIASCGVD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGGL--------VHVYDE-HSEQVNCCHFTN O_anatinus_ENSOANP00000008896 RP------HTDAVYHACFSEDGQRIASCGAD---KTVQVFKAE-TGEKLLEIKA-HEDEVLCCAFSP--DDKFVATCSTDKKVKVWNSQTGKL--------VHTYEE-HTEQVNFCQFSN M_domestica_ENSMODP00000009538 RP------HTDAVYHACFSKDGQRIASCGAD---KTLQVLQAE-TGERLLEVEA-HEDEVLCCAFSK--DGLFIATCSADRKVKIWNSRTGEL--------VHTYDE-HTEQVNCCHFTN T_guttata_ENSTGUP00000009081 RP------HRDAVYHACFSKDKQRIASCGAD---KTLQVFKAE-SGERLLEINA-HDDEILCCTFSA--DGEFVATCSSDKKVKVWNSRTGQC--------RCVYEE-HSEQVNCCQFNN G_gallus_ENSGALP00000037436 RP------HRDAVYHACFSRDRQRIASCGAD---KTLQVFKAE-SGERLLEISA-HDDEILCCTFSA--DDKYVATCSADKKVKIWNSRTGKC--------LYVYEE-HTEQVNCCQFNN A_carolinensis_ENSACAP00000012965 RP------HTDAVYHACFSQDRHRIASCGAD---KTLQIFKAE-SGEKLLEVKA-HDDEVLCCSFSA--DDRFVATCSADKKVKVWNSRTGQP--------VCIFEE-HTEQVNCCQFSN X_tropicalis_ENSXETP00000014654 RP------HKDAVFHACFSSDGQRIASCGAD---KTLQVFKSE-TGEKLLEIEA-HDDEVLCCAFSA--DEKLLATCSADRKVKIWNAKTGKP--------LRVYEE-HIEQVNCCQFTN G_gorilla_ENSGGOP00000008216 XX------XXXXXXXXXXSEDGQRIASCGAD---KTLQVFKAE-TGEKLLEIKA-HEDEVLCCAFST--DDRFIATCSVDKKVKIWNSMTGEL--------VHTYDE-HSEQVNCCHFTN D_rerio_ENSDARP00000008347 HP------HQGAVYYACFSKDGSKIASCGAS---KALRVFKST-SGEKLLELQA-HEEDVLCCAFSP--DDRHIATCASDKKVKLWNVERGVL--------IREFEVEHEEQINHCQFTN O_cuniculus_ENSOCUP00000010200 RP------HTDAVHHASVSA-AHRIASCGAD---XXXXVFKAE-TGEKLLEIKA-HEDEVLCCTFST--DENFIATCSVDRKVKIWNSVTGEL--------VRTYDE-HSEQVNCCCFTN T_rubripes_ENSTRUP00000033561 HP------HQGSVYSACFSRDGTKIASSGAC---KTLKVFKST-TGEKLTEIMA-HDDEVLCCAFSP--DDRLLATCSSDRKVKVWNVEQARL--------LRVFEEEHEEQVNHCQFTN T_nigroviridis_ENSTNIP00000013938 HP------HQGSIYSACFSHDGTKIAASGAY---KTLKVFKST-TGEKLTEIQA-HDDEVLCCAFSP--DDRLLATCSSDRKVKVWNAERAML--------LRVFEEEHEEQVNHCQFTN G_aculeatus_ENSGACP00000026214 HP------HQGSIYSACFSQDGAKIASSGAS---KMLKVFKST-SGEKLMEIQA-HDDEVLCCAFSP--DDRLLATCSSDRKVKVWNVERAML--------LRVFEEEHEEQVNHCQFTN O_latipes_ENSORLP00000019346 HP------HQGSLY-ACFSNDGTKIASCGAT---KNLKVFKST-SGEKLSEFEL--RDEVVCCAFSP--DDSLLAVCSSGRTIQVWNVHQVKL--------LRTFQEEHKEQINHCVFTN C_elegans_Y45F10B.10 KD------WKPGNTVLTLSANHQYILISGNQSDPGVIYAYHIA-SEQLIGTFKG-HTAAVTCLCSSN--DSSLFVSTSFDKTVNVWVFSQSTP--------TMSLTH-HTAKVTCAILTS C_intestinalis_ENSCINP00000010464 QG------DNQEVTCIKSSPNSQHLAVGYVD---GTIRIFSLV-TAESDVTFSG-HRTAISCLAFDK--AGMKLASGSHDTEVVVWDLVNESG--------LYRLKG-HKGIITDCYFVK M_domestica_ENSMODP00000008927 SSSLSLV-PSSMPTAVSLSPNGQWAVVATAS---GIVHLLDTR-TWQEEKSIVS-GCDGISSCLCP---SNSTVFLAASDGLLELWDLQGGWR--------VFQTKA-HQLQITDCCLSP M_domestica_ENSMODP00000027702 QQD-----DQEIITAFDLSPNNEILVTGSRA---LLLTQWAWR-EGNATRVWKAVHTAPVASMAFDP--TSTLLATGGCDGAVRVWDLERRYG--------THHLRG-SPGVVHLLAFHP T_nigroviridis_ENSTNIP00000004057 EHD-----DQEDITCFALSSDDELLVTASRA---LLLKQWDWR-QAQCTRSWRAIHTAPVASMTFDS--TSTLLATGGCDGTIKLWDVVKQYC--------THNLRG-SSGVIQLVQFHP T_guttata_ENSTGUP00000006840 QQE-----EEEDVTAFVLSPDDEVLVTGSRA---LLLRRWHWR-EPSCERTWRAVHTAPVATMAFDP--TATLLATGGCDSTIKIWDMTKHYC--------THNLKG-SSGVVHLVEFHP B_taurus_ENSBTAP00000001564 SSSLSLA-VSSSPTAVAFSPNGQRAAVGTAN---GTVYLLDLR-TWQDERSMVS-GGDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCR--------VLQIQA-HQYQITGCCLSP H_sapiens_ENSP00000262715 SSSLSLA-VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCR--------VLQTKA-HQYQITGCCLSP C_intestinalis_ENSCINP00000019387 SH------DGDDVTCLAVSPDDSMIVTSTKS---LLLKQWEWKMEVKCVRTWRAIHMFPVVSMDFDP--TSTLLATGGSDGTIKVWDMIRQYC--------THNFRG-SPGIVNCVAFHP G_gallus_ENSGALP00000008904 EQD-----DQEDITSFVLSPDDEVLVTGSRA---LLLKQWNWR-ENRCVRTWKAVHIAPVATMVFDS--TSTLLATGGCDSTIKIWDMIKQYC--------THNLKG-SSGVVHLVEFHP P_troglodytes_ENSPTRP00000010340 SSSLSLA-VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCR--------VLQTKA-HQYQITGCCLSP S_cerevisiae_YLR222C SNE-----DEQEITALKLTPDGQYLTYVSQA---QLLKIFHLK-TGKVVRSMKI--SSPSYILDADS--TSTLLAVGGTDGSIIVVDIENGYI--------THSFKG-HGGTISSLKFYG G_aculeatus_ENSGACP00000015863 QHD-----DQEDITSFALSFDDEMLVTASRA---LLLKQWDWR-EAQCTRSWRAIHTVPVASMTFDS--TSTLLATGGCDGTIKLWDVLKQYC--------THNLKG-SSGVVHLVQFHP B_taurus_ENSBTAP00000027147 EQE-----DQEDITAFDLSPDDKVLVTASRA---LLLAQWAWQ-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDVVRCYG--------THHFRG-SPGVVHLVAFHP A_gambiae_AGAP009615-PA EQETDGEIAEDVIYTFAVSNTGNSIVSGHRS---GLLKLWDGE-KHTVQKMWKTVHQGPISRLVFSP--TDSVIASGGSDSTIRLWDPTEQVC--------LGTLRG-AEGLINVIVFHP D_rerio_ENSDARP00000023281 EG------KKHEVTYLCPSPDGVHIAVGYED---GGVRIFSLL-NGESNVSFSG-HKSAVSVIKYDA--LGARLVTGSRDTDVIVWDVINECG--------LYRLKG-HKDAITQVLFLE T_rubripes_ENSTRUP00000017221 EHD-----DQEDITSFALSSDDELLVTASRA---LLLKQWDWR-QAQCTRSWRAIHTAPVASMDFDS--TSTLLATGGCDGTIKIWDVVKQYC--------THNLRG-SSGVVHLVQFHP A_gambiae_AGAP004827-PA P-------GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM-SNSLVHTFKG-HSGPITYMKVL----SQYLVTASEDTSVIVWDMKTLAM--------KLRLRE-HIAPALCATLAL A_aegypti_AAEL001276-PA P-------GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM-SNSLVHTFKG-HSGPVTYMKVQ----WQYLLTASEDTSVIVWDMQTLAL--------KLRLCE-HIAPVTCCTLAL M_mulatta_ENSMMUP00000021364 SSSLSLA-VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-TWQEEKSLVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCR--------VLQTKA-HQYQITGCCLSP P_pygmaeus_ENSPPYP00000006332 SSSLSLA-VSSSPTAVAFSTNGQRAAVGTAN---GTVYVLDLR-TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFNGLLELWDLQHGCR--------VLQTKA-HQYQITGCCLSP O_anatinus_ENSOANP00000004860 QG------LKQEVSRLCPSPDGLHLAVGYED---GTVRIFSLL-SGENTVTFNG-HKAAVTALKYDH--LGGRLVSGSKDTDVIVWDVINESG--------LFRLKG-HKDAVTEALFLR D_melanogaster_FBpp0085899 S-------GTGCIRAVWLAPSKQHLILATSS---GDVQQWHIM-SNSLDHIFKG-HTAAVTCLLVAPQSDSELLLTGSEDATVLVWHVGLRER--------RAHIKNAHTAPITGVAAGA O_latipes_ENSORLP00000010395 QG------QKHEVSFLCPSPDGVHVAVGYED---GAVRIFSLL-NGESSVAFNG-HKTAVTVMNYDA--LGARLVTGSKDTDVIVWDIINECG--------LYRLRG-HKDAITQALFLK R_norvegicus_ENSRNOP00000012235 --SLSLP-ISSSPTAVAFSPNGQRAAVGTAG---GTIYLLNLR-TWQEEKALVS-GCDGISSFAFL---SDTALFLTTFDGLLELWDLQHGCW--------VFQTKA-HQYQITGCCLSP S_cerevisiae_YCR057C EYE-----HRKNIAAIDLNKQGTLLISIDED---GRAILVNFK-ARNVLHHFN--FKEKCSAVKFSP--DGRLFAL-ASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ G_gorilla_ENSGGOP00000009169 EQE-----DQEDITAFDLSPDNEVLVTASRA---LLLAQWAWQ-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIVQHYG--------THHFRG-SPGVVHLVAFHP T_nigroviridis_ENSTNIP00000007980 EG------QKHEVTFLCPSPDGVHVAVGYED---GAVRIFSLL-NGESNVSFNG-HKSAVSVMRYDG--LGARLVTGSKDTDVIVWDIINECG--------LYRLRG-HKDLITQALFLR H_sapiens_ENSP00000331815 EQE-----DQEDITAFDLSPDNEVLVTASRA---LLLAQWAWQ-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIVRHYG--------THHFRG-SPGVVHLVAFHP M_mulatta_ENSMMUP00000010429 EQE-----DQENITAFDLSPDDEVLVTASRA---LLLAQWAWR-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRIWDIVRHYG--------THHFRG-SPGVVHLVAFHP X_tropicalis_ENSXETP00000035244 PDSKSLE-IPSLLGCVSLSPSGRMAAVGASS---GALHLINTD-SGEEVRILHS-GCDGVSACNFI---SDDLLCVGSYDGILEIWKISDGCR--------MHRAEA-HRRQITGCCVSP P_troglodytes_ENSPTRP00000001997 QG------LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-SGEGNVTFNG-HKAAITTLKYDQ--LGGRLASGSKDTDIIVWDVINESG--------LYRLKG-HKDAITQALFLR P_pygmaeus_ENSPPYP00000007898 EQE-----DQESITAFDLSPDDEVLVTASRA---LLLAQWAWQ-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIVRHYG--------THHFRG-SPGVVHLVAFHP M_musculus_ENSMUSP00000046830 EQE-----DQEDITSFDLSPDDEVLVTASRA---LLLAQWAWR-EGTVTRLWKAIHTAPVASMAFDA--TSTLLATGGCDGAVRVWDIVQHYG--------THHFRG-SPGVVHLVAFHP R_norvegicus_ENSRNOP00000018405 EQE-----DQEDITAFDLSPDDEVLVTASRA---LLLAQWAWR-EGTVARLWKAIHTAPVASMAFDA--TSTLLATGGCDGAVRVWDIVQHYG--------THHFRG-SPGVVHLVAFHP A_aegypti_AAEL004526-PA DAD-----ESDAVYTFALSKDSHNVVSAHRS---GLMKLWDKN-SRQVSKMWRGLHQGPITKLVFSD--DDTLIASGGTDTTVRVWDPKEQVC--------KGTLRG-CQGVINLLVFHP P_pygmaeus_ENSPPYP00000001131 QG------LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-SGEGNVTFNG-HKAAITTLKYDQ--LGGRLASGSKDTDIIVWDVINESG--------LYRLKG-HKDAITQALFLR P_troglodytes_ENSPTRP00000053800 EQE-----DQEDITAFDLSPDNEVLVTASRA---LLLAQWAWQ-EGSVTRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIVRHYG--------THHFRG-SPGVVHLVAFHP M_mulatta_ENSMMUP00000011166 QG------LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-SGEGNVTFNG-HKAAITTLKYDQ--LGGRLASGSKDTDVIVWDVINESG--------LYRLKG-HKDAITQALFLR R_norvegicus_ENSRNOP00000026726 QG------LKQEVTCLCPSPDGLHLAVGYED---GAIRVFSLL-SGEGNITFNG-HRAAVTSLKYDQ--LGGRLASGSKDTDVIIWDVINESG--------LYRLKG-HKDAVTQALFLR O_anatinus_ENSOANP00000015573 EQE-----DQEDITAFVLSPDDEVLVTGSRA---LLLTQWAWR-QAQRTRTWRAVHSAPVASMAFDP--TATLLATGGCDGSVKLWDVVRQHG--------THNLCG-SPGVVHLVAFHP T_guttata_ENSTGUP00000013749 KG------LKQQVSCLCPSPDGLHLAVGYED---GAIRVFNLL-SGESTITFNG-HRAAVTALQYDH--LGGRLVSGSKDTEVIVWDVINESG--------LYRLRG-HKDVITQVLFLK C_familiaris_ENSCAFP00000028736 EQE-----DQEDITAFELSPDDQVLVTATRA---LLLAQWAWR-EGSITRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIVRHYG--------THHFRG-SPGVVHLVTFHP X_tropicalis_ENSXETP00000015707 EQD-----DQEDITSFALSPDDEILVTGSRA---LLLKQWDWK-QGTCSRTWKAIHTAPVATMTFDP--TSTLLATGGCDSTIKIWDVIKQYC--------THNLKG-SSGVVHLVQFHP E_caballus_ENSECAP00000009299 TTSLSLA-VSSSPTAVAFSPSGQRAAVGTAS---GTVYLLDLR-TWQEEKSVVS-GCDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCR--------VLQTNA-HQYQITSCCLSP M_domestica_ENSMODP00000006461 QG------LKHEVTCLCPSPDGLHLSVGYED---GSIRIFSLL-SGEGNVTFNG-HKAAVTALSYDQ--LGGRLVSGSKDTDVIVWDVINESG--------LYRLKG-HKDAITQVLFLR M_musculus_ENSMUSP00000006444 --SLSLT-MSSSPTAVAFSPNGQRAAVGTAS---GTIYLLNLK-TWQEEKAVVS-GCDGISSFAFL---SDTALFLTTFDGHLELWDLQHGCW--------VFQTKA-HQYQITGCCLSP H_sapiens_ENSP00000308179 QG------LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-SGEGNVTFNG-HKAAITTLKYDQ--LGGRLASGSKDTDIIVWDVINESG--------LYRLKG-HKDAITQALFLR T_rubripes_ENSTRUP00000006345 EG------QKHEVTFLRPSPDGVSIAVGYED---GAVRIFSLL-NGESNVSFNG-HKSAVSIICYDE--LGARLVTGSKDTDVIVWDIINECG--------LYRLRG-HKGLITQALFLK E_caballus_ENSECAP00000017445 EQE-----DQEDITAFDLSPDDEVLVTASRA---LLLAQWAWR-EGSVIRLWKAIHTAPVATMAFDP--TSTLLATGGCDGAVRVWDIMRHYG--------THHFRG-SPGVVHLVAFHP 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 KS-NHLLLATGSNDFF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDELLASCSADGTLRLWDVRS--AN--E---RKSINV---------KRFFLSSEDPPE E_caballus_ENSECAP00000022364 NS-HHLLLATGSSDSF--LK----LWDLNEKD---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGSLKLWDVKS--AN--E---RKSINV---------KQFFISSEEPQE B_taurus_ENSBTAP00000028867 NS-NHLLLATGSNDYF--LK----LWDLNQEE---CRNTMFGH-NSVS--HCRF------SPDDQVLASCSADGTLKLWDVKS--AN--E---RKSINV---------KQFFLNSEEPQE P_troglodytes_ENSPTRP00000042795 SS-HHLLLATGSSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDATS--AN--E---RKSINV---------KQFFLNSEDPQE P_pygmaeus_ENSPPYP00000005543 SS-HHLLLATGSSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDVTS--AN--E---RKSINV---------KQFFLNSEDPQE H_sapiens_ENSP00000353059 SS-HHLLLATGSSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDATS--AN--E---RKSINV---------KQFFLNLEDPQE R_norvegicus_ENSRNOP00000010869 KS-NHLLLATGSNDSF--LK----LWDLNQKE---CRNTMFGHTNSVT--HCRF------SPDDELLASCSADGTLKLWDVRS--AN--E---KKSINV---------KRFFLSSEDPPE M_mulatta_ENSMMUP00000038848 SS-HHLLLATGSSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDVTS--AN--E---RKSFNV---------KQFFLNSEDPQE C_familiaris_ENSCAFP00000009806 NS-HYLLLATASSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDVKS--AN--E---RKSINV---------KQFFLNSEEPQE O_anatinus_ENSOANP00000008896 TS-SHPLLATCSNDQF--LK----LWDLNQKG---CRNTMFGHSDSVN--HCKF------SPDDKYLASCSADGTLKLWEVAS--AN--E---WKSIDV---------SKFFQTSEH-EE M_domestica_ENSMODP00000009538 ME-HHLLLATGSSDCF--LK----LWDLNKQE---CRNTLFGHMNSVN--HCQF------SPDDTHLASCSADGTLKLWDVSS--AN--E---CSSIDV---------KQHFLTGDGRQD T_guttata_ENSTGUP00000009081 KS-GQYLLATCSNDTF--IK----IWDLNKKY---CRNTMIGHENSVN--HCRF------SPNDEYVASCSTDGTVKLWESRS--GN--E---LKSIEI---------KDFFKNADEQPD G_gallus_ENSGALP00000037436 RR-GQYLLATCSDDTY--IKNTVQLWDLKDKY---CRNTMFGHVNAVS--HCRF------SPNDDYIASCSTDGTVKLWNVHS--AN--E---LRTIEI---------KDFFRNADEQQD A_carolinensis_ENSACAP00000012965 TNHNQFLLATCSNDSF--IK----LWDLNKKY---CRNTLFDHSSSVT--HCRF------SPNDKYIASCSADGTLMLWYAQS--AN--K---RKTVDI---------RGNFRNVDEYQD X_tropicalis_ENSXETP00000014654 SL-SAPLLATCSNDCL--IK----LWNSEKNY---CHNTLIGHIESVY--HCRY------SPDDRYLASSSMDGSLKIWDVES--AN--E---EKSIEV---------AKLFENEDEAQP G_gorilla_ENSGGOP00000008216 SS-HHLLLATGSSDCF--LK----LWDLNQKE---CRNTMFGHTNSVN--HCRF------SPDDKLLASCSADGTLKLWDVTS--AN--E---RKSINV---------KQFFLNSEDPQE D_rerio_ENSDARP00000008347 TG-RRVLLATCSNDKFTNTK----LWNPNKKT---SQNTMFGHMEPVN--HCCF------SPNDLYLATSSSDGSLKLFEVSS--AN--E---WKSIDV---------DSFFPESDE--- O_cuniculus_ENSOCUP00000010200 QS-QYLLLATGSSDFF--LK----LWDLNQNV---CRNTMFGHTNSVN--HCRF------SPDDKLLSSCSADGTLKLWDVKS--AN--E---VKSINV---------KKFFLTSEDPQE T_rubripes_ENSTRUP00000033561 TM-RRLLLVTCSNDACMNVK----LWNLNKPS---SQNTMFGHFEPVN--HCCF------SPDDAIVSTSSNDGTVKLFRASS--AN--E---WKTISV---------RDQVAENDE--- T_nigroviridis_ENSTNIP00000013938 TM-RRLLLVTCSNDEFMNVK----LWNLNKPS---SQNTMFGHTEPVN--HCCF------SPDDTYVSTASNDGTVKLFQVSH--AN--E---WKTINV---------RKRLTENDE--- G_aculeatus_ENSGACP00000026214 STTPRLLLATCSNDKVLNTK----LWNLNKPS---SQNTIFGHFEPVN--HCCF------SPSDTYLSTSSNDGTVKLFHTSS--AN--E---WKTINV---------RDAFAESDE--- O_latipes_ENSORLP00000019346 TT-RRLLLATCSNDQMGNAK----LWNLNKPT---CQNTIFGHFEPVN--HCCF------SPDDNYVSTSSNDGTVKLFEATS--GN--I---WKSIDV---------RGMFKDPDN--- C_elegans_Y45F10B.10 D---DQYLITASADSS--AK----MIKLETGE---VMRSFNDHTGSVV--SLQL------TSNNQFLITGSGDFVVQMWDVTN--GK--C---ISRMGG--------------------- C_intestinalis_ENSCINP00000010464 Q---RNMLITSSKDTY--VK----WWDLDTQH---CFKTMVGHRSEVW--SFCL------TPDERRIITGSGDSELRIWSVEF--IA--N---KDSMEA--PLVKLQKTKLDDVTSNDVT M_domestica_ENSMODP00000008927 D---HRLLATVSLDRH--LK----LWDTVHGK----LASQHLSQKPLN--CVAF------HPEEQVITTGNWAGCLSVLRLDS--LT--V---TMFIGL--------------------- M_domestica_ENSMODP00000027702 DP-EQLLLFSSAMDCT--IR----VWGLQAGT---CLAMLSSHYSTVT--SLAF------SDDGHTMVSSGRDKICTVWDLKT--RT--S---VKTVPV--------------------- T_nigroviridis_ENSTNIP00000004057 DI-DRLQLFSSSMDCS--IR----IWDLSSSQ---CVCVLQSHYSAVT--SLSF------SLDGDTMVSSGRDKICTVWDLKQ--QK--A---KRTIPI--------------------- T_guttata_ENSTGUP00000006840 DL-SRLQLFSSCIDYK--IR----IWDLSSSK---CLAVLEGHFSAVT--SLAF-------ADGNSLLSSGRDKICMVWDLET--RQ--S---KRTIPV--------------------- B_taurus_ENSBTAP00000001564 D---RRLLATVCLGGG--LK----LWDVVRGQ----LASQHTCPKPLN--CVAF------HPEGQVIAVGGWAGSFSFFHVDG--LR--V---TKELGA--------------------- H_sapiens_ENSP00000262715 D---CRLLATVCLGGC--LK----LWDTVRGQ----LAFQHTYPKSLN--CVAF------HPEGQVIATGSWAGSISFFQVDG--LK--V---TKDLGA--------------------- C_intestinalis_ENSCINP00000019387 N---NLTLYSAADDYN--IR----VWDLNSSK---LVKVLNSHVSSVT--CLKF-------SNVDCLVSAGRDNVVCLWNVKEGGNE--P---YKVIPV--------------------- G_gallus_ENSGALP00000008904 DI-SRLQLFSSSMDYK--IR----IWDLNSSK---CVAVLDGHFSAVT--SLAF------TADGNTLISSGRDKICMVWNLKT--RE--S---IRTIPI--------------------- P_troglodytes_ENSPTRP00000010340 D---CRLLATVCLGGC--LK----LWDTVRGQ----LAFQHTYPKSLN--CVAF------HPEGQVIATGSWAGSISFFQVDG--LK--V---TKDLGA--------------------- S_cerevisiae_YLR222C QL-NSKIWLLASGDTNGMVK----VWDLVKRK---CLHTLQEHTSAVR--GLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNM--KK--KCKLLKTLPV--------------------- G_aculeatus_ENSGACP00000015863 DI-SKLQLFSSSLDCG--IR----LWDLRSSQ---CVCVLQSHYSAVT--SLSF------TPDGDTMVSSGRDKICTVWDLKT--RK--A---TRTVPV--------------------- B_taurus_ENSBTAP00000027147 DP-ARLLLFSSAADTS--IR----VWSLQERS---CLAVLTAHYSAVT--SLTF------SADGHTMLSSGRDKICVIWDLRS--LQ--A---TRTVPV--------------------- A_gambiae_AGAP009615-PA DA-DSKIVVAVGDDTK--IR----AWDYESRK---QVKTFEGHFSRVT--GVSF------SEDRTHLVSAGRDKILILWNFES--QQ--A---VKTIPV--------------------- D_rerio_ENSDARP00000023281 S---KNLLITSSKDSF--VK----WWDLDTQH---CFKTMVGHRSEVW--GMVL------LNQENRLLTGSADSELRAWDIQD--IE--E---VKELGE--PQEKKVRT-LLEDEE--ED T_rubripes_ENSTRUP00000017221 DI-SRLKLFSSSMDCS--IW----MWDLSTSL---CVCMLQSHYSAVT--SLSF------SPDGDTMISSGRDKICTVWDLKQ--QN--A---KRAIPV--------------------- A_gambiae_AGAP004827-PA D---NKYVISGSDDSS--II----VSLLETGK---LVTKFDHHRGPVS--ALHM------SYPSEVLVSSSHDATVCLWSLEN--FT--L---LNCIQM--------------------- A_aegypti_AAEL001276-PA D---NKYLITSSEDSS--II----VALFESGK---VITKIDHHRGPVT--AIHV------AMPSEVLVSSSHDGTVCLWSLDN--FT--L---LNCIQL--------------------- M_mulatta_ENSMMUP00000021364 D---RRLLATVCLGGC--LK----LWDTVRGQ----LAFQHTYPKPLN--CVAF------HPEGQVIATGSWAGSISFFQVDG--LK--V---TKDLGA--------------------- P_pygmaeus_ENSPPYP00000006332 D---RRLLATVCLGGC--LK----LWDTVRGQ----LAFQHTYPKSLN--CVAF------HPEGQVIATGSWAGSISFFQVDG--LK--V---TKDLGA--------------------- O_anatinus_ENSOANP00000004860 E---RDLLVTSGKDTM--VK----WWDLDTQH---CFKTMVGHRTEVW--GLAL------VSDDRRLITGAADSELRAWDITW--AQGAQ---PRDPAE--PDAKRARGPPPATPGEPQE D_melanogaster_FBpp0085899 N---NTLIISSSEDAS--IA----ITDLASGK---LRHRITHHRGPVS--GIVV------AGACDVLISGGLDRTICVWDLDN--FT--L---LNTMQM--------------------- O_latipes_ENSORLP00000010395 N---KNLMVTSSKDSF--VK----WWDLDTQH---CFKTMVGHRSEVW--ALAL------LKQEKRLLTGSADSELRAWDIAA--LE--E---IEDKTEGGPKVKKGKTLLEEDED--DE R_norvegicus_ENSRNOP00000012235 D---RRLLATVCLGGY--VK----LWDTVQGQ----LAFQYTHPKSLN--CITF------HPEGQVVATGNWSGIVTFFQADG--LK--V---TKELGG--------------------- S_cerevisiae_YCR057C D---SRFILTTSKDLS--AK----IWSVDSEEKNLAATTFNGHRDYVM--GAFF------SHDQEKIYTVSKDGAVFVWEFTK--RP--S---DDDDNE--------------------- G_gorilla_ENSGGOP00000009169 DP-TRLLLFSSATDAA--IR----VWSLQDRS---CLAVLTAHYSAVT--SLAF------SADGHTMLSSGRDKICIIWDLQS--CQ--A---TRTVPV--------------------- T_nigroviridis_ENSTNIP00000007980 D---RNLLVTSSKDSF--VK----WWDLDTQH---CFKTIVGHRSEVQCGGMVL------LDQDNRLLTGSADSELRAWDITY--LQ--E---IDESPE--EVQKPLSS-VLSRLL--AH H_sapiens_ENSP00000331815 DP-TRLLLFSSATDAA--IR----VWSLQDRS---CLAVLTAHYSAVT--SLAF------SADGHTMLSSGRDKICIIWDLQS--CQ--A---TRTVPV--------------------- M_mulatta_ENSMMUP00000010429 DP-TRLLLFSSAADAA--IR----VWSLQDRS---CLAVLTAHYSAVT--SLTF------SADGHTMLSSGRDKICVIWDLQS--CQ--A---TKTVPV--------------------- X_tropicalis_ENSXETP00000035244 D---QRQLITCSLDYQ--LK----LWETSRGS----LLGSISFPYPLA--CTTF------HPRGHVVAVGSWDGKITVLRLEN--WE--K---TAVLCG--------------------- P_troglodytes_ENSPTRP00000001997 E---KNLLVTSGKDTM--VK----WWDLDTQH---CFKTMVGHRTEVW--GLVL------LSEEKRLITGASDSELRVWDIAY--LQ--E---IEDPEE--PDPKKIKGSSPGIQDTLEA P_pygmaeus_ENSPPYP00000007898 DP-TRLLLFSSATDAA--IR----VWSLQDRS---CLAVLTAHYSAVT--SVAF------STDGHTMLSSGRDKICIIWDLQS--CQ--A---ARTVPV--------------------- M_musculus_ENSMUSP00000046830 DP-TRLLLFSSAVDTS--IR----VWSLQDRS---CLAVLTAHYSAVT--SLSF------SEGGHTMLSSGRDKICIVWDLQS--YQ--T---TRTVPV--------------------- R_norvegicus_ENSRNOP00000018405 DP-TRLLLFSSAVDTS--IR----VWSLQDRS---CLAVLTAHYSAVT--SLSF------SEDGHTMLSSGRDKICIVWDLRS--YE--T---SRTVPV--------------------- A_aegypti_AAEL004526-PA DV-ESKILLAAGDDVK--IN----AWNYETRE---LVKSFAGHFSKVT--GVSF------TSDHKFLVSSGRDKILIMWNYET--QQ--A---VKTIPV--------------------- P_pygmaeus_ENSPPYP00000001131 E---KNLLVTSGKDTM--VK----WWDLDTQH---CFKTMVGHRTEVW--GLVL------VSEEKRLITGASDSELRVWDIAY--LQ--E---IEDPEE--PDPKKIKG-SPGIQDTLEA P_troglodytes_ENSPTRP00000053800 DP-TRLLLFSSATDAA--IR----VWSLQDRS---CLAVLTAHYSAVT--SLAF------SADGHSMLSSGRDKICIIWDLQS--CQ--A---TRTVPV--------------------- M_mulatta_ENSMMUP00000011166 E---KNLLVTSGKDTM--VK----WWDLDTQH---CFKTMVGHRTEVW--GLVL------VSEEKRLITGASDSELRVWDIAY--LQ--E---IEDLEE--PDPKKIKGSSPGVQDTLEA R_norvegicus_ENSRNOP00000026726 E---RNLLVTSGKDTM--VK----WWDLDNQH---CFKTMVGHRTEVW--GLVL------VSEETRLITGAADSELRAWDIAY--LQ--E---IDDPEE--PEPKKIKE-CPGIQDTPEA O_anatinus_ENSOANP00000015573 DI-SRLQLFSSAMDYK--IR----LWDLRSAA---CVAVLEGHYSAVT--SLAF------GPDGDTMISSGRDKICTVWDLKT--RQ--T---KRTIPV--------------------- T_guttata_ENSTGUP00000013749 E---KNLLITCAKDTL--VK----WWDLDTQH---CFKTLVGHRAEVW--GMAL------LSKEKRLITGSADSELRVWDLTY--IQ--E---VKDHDE--PESKKSKGSSSPGAEENNE C_familiaris_ENSCAFP00000028736 DP-ARLLLFSSAADAT--IR----MWSLQDQS---CLAVMTAHYSAVT--SLTF------SADGHTMLSSGRDKICVIWDLQS--HQ--A---TRTVPV--------------------- X_tropicalis_ENSXETP00000015707 DM-SRLQLFSSSMDYK--IR----LWDLKTSK---CLCVMETHFSAVT--SLCF------SPDGNTMISSGRDKICTVWDLET--KS--P---KRTVPV--------------------- E_caballus_ENSECAP00000009299 D---NRLLATVCLGGC--LK----LWDTVRGQ----LAFQHTCPKPLN--CVAF------HPEGQVVAIGSWSGSFSFFQVDG--LK--V---TKELGA--------------------- M_domestica_ENSMODP00000006461 E---KNLLITSGKDTV--VK----WWDLDTQH---CFKTMVGHRTEVW--GMVL------VSEEKRLITGSADSELRAWDITY--IE--E---LKDLGE--PNSKKSRGSSLGTQENHET M_musculus_ENSMUSP00000006444 D---RRLLATVCLGGY--LK----LWDTVRGQ----LAFQYTHPKSLN--CVAF------HPEGQVVATGSWAGSITFFQADG--LK--V---TKELGA--------------------- H_sapiens_ENSP00000308179 E---KNLLVTSGKDTM--VK----WWDLDTQH---CFKTMVGHRTEVW--GLVL------LSEEKRLITGASDSELRVWDIAY--LQ--E---IEDPEE--PDPKKIKGSSPGIQDTLEA T_rubripes_ENSTRUP00000006345 D---KNLLVTSSKDSF--VK----WWDLDTQH---CFKTIVGHRSEVW--GMVL------LDRESRLLTGSADSELRAWDITY--LQ--E---VKAEGE--PEEKRGKIELVEDEDEGDQ E_caballus_ENSECAP00000017445 DP-ARLLLFSSAADAT--IR----MWSLQERS---CLAMLTAHYSAVT--SLTF------SADGHTMLSSGRDKICIVWDLQS--CQ--A---TKTVPV--------------------- 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 DVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGHHSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHL---------------------SWVH-----GVM E_caballus_ENSECAP00000022364 DMEVIVKCCSWSSDGARIMVAAKNKIFLVDVHTCGLLAEIHTGHHSTIQYCDFSPSNHLAVVALSQYCVELWNMDSCLKVADCRGHL---------------------SWVH-----SVM B_taurus_ENSBTAP00000028867 DLEVIVKCCSWSADGAKIMVAAKNKVFLFDIHSSGLLAEMHMGHHSAVQYCDFSPHNHLAVVALSQYCVELWSMDSGLKVADCRGHL---------------------SWVH-----CVM P_troglodytes_ENSPTRP00000042795 DMEVIVKCCSWSADGARIIVAAKNKIFLFDIHTSGLLGEIHTGHHSTIRYCDFSPQNHLAVVALSQYCVELWNIDSRSKVADCRGHL---------------------SWVH-----GVM P_pygmaeus_ENSPPYP00000005543 DMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNIDSRSKVADCRGHL---------------------SWVH-----GVM H_sapiens_ENSP00000353059 DMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL---------------------SWVH-----GVM R_norvegicus_ENSRNOP00000010869 DVEVIVKCCSWSADGDRIIVAAKNKVLVMETQSSGKSSHCFSLLRRPLRIYFLNPFDNLMLIDSSKFAVQLLHHTIRLSFNGCEPGL---------------------SSLM-----SQL M_mulatta_ENSMMUP00000038848 DMEVIVKCCSWFADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNIDSCSKVADCRGHL---------------------SWVH-----GVK C_familiaris_ENSCAFP00000009806 DMEVIVKCCSWSADGTRIMVAAKNKIFLFDIHTGGLLAEIHTGHHSTIQYCDFSPQNHLAVVALSQCCVELWNMDSCLKVADCRGHL---------------------SWVH-----CVM O_anatinus_ENSOANP00000008896 DVEVLVKCCSWTTDGATIMVTAKNMIFLFDVKTSGLSAEIQTSHHSTIQYCDFYPCSHLAVVALSHYCVELWNTDSCLKVADCRGHL---------------------SWVH-----CVT M_domestica_ENSMODP00000009538 DVDVVVKCCSWSNDGARLMAAAANRLLVFDVQSRNLLGEIHTSHSSTIRFCDFFPKSHLAAVALSHYCVELWNTDTGLKVADCRGHL---------------------SWVH-----CVA T_guttata_ENSTGUP00000009081 DVEVLVKCCSWSRNGDKILVVAKNKLLLFDINTCGLLTQVIVSHHSTIQYCDFCPGDELVAVALSHCSVELWNIKSLSKVAYCRGHM---------------------SWVH-----CVT G_gallus_ENSGALP00000037436 DVEVLVKCCSWSRSSDTILVVAKNKLLLFDVTTSNLLTQVIISHHSTIQYCDFCAGDELVAVALSHCSIELWNIKSLSKVADCRGHT---------------------SWVH-----CVT A_carolinensis_ENSACAP00000012965 DMEVLVKCCSWSSDSTTIVVAAKNKLFRTDTKISTSLPEVLINHHYTIQYCDFCPNSQMVAVALSNYSVEIWNIESCSKIADCRGHM---------------------SWVH-----SVT X_tropicalis_ENSXETP00000014654 --EVLLKCCAWSNDGSRIMVTARNFLCIYDAERCNLLSQLKACHQ--ILYCDFCTTNQIAALALSHYVVQLWDIDSSTKIADFNAHL---------------------SWVH-----CVK G_gorilla_ENSGGOP00000008216 DMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNIDSRSKVADCRGHL---------------------SWVH-----GVM D_rerio_ENSDARP00000008347 EIKAMVKCSTWSADGSQIICAARNTVFVFDVETSDLLLELKTSRLSTIQFCHACPNSSLLAVALSHYTVELWNFESSKKKAECSGHL---------------------SWVH-----CVQ O_cuniculus_ENSOCUP00000010200 DMEVIVKCCSWSADGARIMVAAKNKILXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLWNMDSRLKVADCRGHL---------------------SWVH-----GVM T_rubripes_ENSTRUP00000033561 --EVLVKCSTWTADGKRIICAARNAVLVFDVETSDMLLEIKTSRLSMVQYCHACPTSNLLAIAFSNYAVELWDLEANKKMADCSGHL---------------------SWVQ-----RVQ T_nigroviridis_ENSTNIP00000013938 --EVLVKCSTWTADGKQLICAARNAVLVFDVETSDLLSEIKTSRLSTVQYCHACPTNNLLAIAFSNYAVELWDLEANKKMADCSGHL---------------------SWVQ-----LVQ G_aculeatus_ENSGACP00000026214 --EVLVKCSTWTADGKRIICAARNAALVFDVETSDMLLEIRTNRLSTVQYCHACPTSNLLAIAFSNYAVELWDLEANKKMADCSGHL---------------------SWVQ-----RVQ O_latipes_ENSORLP00000019346 DDEVAVRCSSWTADGKRILCAARNAALMFDVETSDLLLEIRPSFLSTVLHCDVCPTSNLLAMALSNYAVELWDIEENAKKADCSGHL---------------------SWVE-----RVQ C_elegans_Y45F10B.10 --------------------------------LMAPVSTLAIT-----------SNDAFVVVACEDETLKVFSTVGGQELHELMGHE---------------------GKVN-----SLV C_intestinalis_ENSCINP00000010464 SDDVISD-DVMQGIEERLVSCIKVGSVMRK--GRDRVVTLKVS-----------KDGRLLTCHGNDKMVEFFRIFDEAEVALRIKKKLKRAKKKQKN------EGQEENDITI----ERS M_domestica_ENSMODP00000008927 ------------------------------KGSESSVRAVTFA-----------PSGTVLAASHLDGTVELWAWQKGAQLASFPAHL---------------------GYVA-----SAL M_domestica_ENSMODP00000027702 -------------------FESVESVVLLP--KGGD-PELGVN-----------TPGLHLLTAGDRGVLRIWEVESGSCVYTQKPVA---------------GEGGPGREIT-----HCA T_nigroviridis_ENSTNIP00000004057 -------------------YEAVEGAVILP--ENQDFSQIGVK-----------KPKLHFITAGSKGILRVWDPNTARCVFSQTLTGVSAA-------------DNP-RSLT-----HLL T_guttata_ENSTGUP00000006840 -------------------YETVEAAVLLP--EKGDFSQLGVK-----------KQGLHFVTAGSKGVLRVWDVATAACVHSQAVPF-------------TLREEPSEHSLS-----QC- B_taurus_ENSBTAP00000001564 --------------------------------PGASVRTLAFG-----------VPGRVVAVGRLDRMVELWAWQEGARLAAFPAHQ---------------------GFVA-----TAL H_sapiens_ENSP00000262715 --------------------------------PGASIRTLAFN-----------VPGGVVAVGRLDSMVELWAWREGARLAAFPAHH---------------------GFVA-----AAL C_intestinalis_ENSCINP00000019387 -------------------FESVEACFNFE--RKEN------------------ETGFLIITAGSKGQLRVWESSNGKCVFTNPDND-----------------SNVASGYI-----HAK G_gallus_ENSGALP00000008904 -------------------YESVEAAVLLP--EQGDFSQLGVK-----------KQGLHFLTAGSKGVLKVWEVATAACVYSQPVPF----------EPVESEEEASEHSLT-----HCM P_troglodytes_ENSPTRP00000010340 --------------------------------PGASIRTLAFN-----------VPGGVVAVGRLDSMVELWAWREGARLAAFPAHH---------------------GFVA-----AAL S_cerevisiae_YLR222C -------------------NQQVESCGFLK--DG--------------------DGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPI-------------------EELFII-----GVL G_aculeatus_ENSGACP00000015863 -------------------YETVEGVVLLP--DDEDLSDIGVT-----------SKNLHFITAGSKGVLRVWEASTARCVYAQTLNSTLAAVSE---KEEEKDDDNDHCSLT-----YLL B_taurus_ENSBTAP00000027147 -------------------FESVEAAVLLP--EEP-APELGVK-----------SAGLHFLTAGDQGALRVWEAASGRCVHAQQRLR------------------GPGRELT-----HCT A_gambiae_AGAP009615-PA -------------------YETLESVVVLP--------------------------------AGLRGLIKVWEMTGAKIIFKQSNSL------------VAKAAEEGGLAIT-----HLF D_rerio_ENSDARP00000023281 EEGP----D--EEPEERILSCKKAGSILRE--ARDRVVSLVTD-----------AKAKVLACHGLDATLEVFTVLSEEEIQRKMDRKLKKAKKKAKS----QEGGEEASEPVV----ERK T_rubripes_ENSTRUP00000017221 -------------------YEAVEGVIFLP--ENQDFSQIGVK-----------NPKLHFVTAGSKGILRVWDPNTARCVFSQTLGTVSVKKDDEEGEEEEKKDDNP-RSLT-----HLL A_gambiae_AGAP004827-PA ---------------------------------SQPILNMQIS-----------CDSTFLLAHCADNGLYLRSLTTGTELHALKGHK---------------------SKVR-----ALC A_aegypti_AAEL001276-PA ---------------------------------PHPVLNFQIS-----------CDSIFLLAYCEDNGLYLRALATGTELHALKGHK---------------------SKVR-----ALC M_mulatta_ENSMMUP00000021364 --------------------------------PGASVRTLAFN-----------VPGGVVAVGRLDSMVELWAWREGARLAAFPAHH---------------------GFVA-----AAL P_pygmaeus_ENSPPYP00000006332 --------------------------------PGASVRTLAFN-----------VPGGVVAVGRLDSMVELWAWREGARLAVFPAHH---------------------GFVA-----AAL O_anatinus_ENSOANP00000004860 EE------D--EAPEERILSCTKAGSIMRE--GRDRVVGLAAD-----------RTGTVLACHGSDSVLELFRVLSEEEIQKKIDKRMKLARKKAKR--VERAGRRRPPQRSFPAVSPVT D_melanogaster_FBpp0085899 ---------------------------------TSAVLRIDIS-----------WNSVFLLALCEDNALYVRTLATGKELHTLKGHK---------------------SKIR-----SIS O_latipes_ENSORLP00000010395 EEKE----D--ESLDERILSCKKAGSILRE--ARDRVVSMTTD-----------SRARVVACHGNDSVLELFTVLTEEEVQRKMTKKMKKARKKAAKTSALEEAGGAAAEPVV----ERT R_norvegicus_ENSRNOP00000012235 --------------------------------PGPSVRTLAFS-----------APGKVVALGRIDGTVELWAWQEGTRLAAFPAQC---------------------GGVS-----TVL S_cerevisiae_YCR057C ----------------------------SE--DDDKQEEVDIS-----------KYS--------------WRITKKHFFYANQ------------------------AKVK-----CVT G_gorilla_ENSGGOP00000009169 -------------------FESVEAAVLLP--EEP-VSQLGVK-----------SPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPP------------------GPGRELT-----HCT T_nigroviridis_ENSTNIP00000007980 PLSL----P--PPSLQRILSCHKAGSILRE--ARDRVVSLTTD-----------ARSAVIACHANESVLELFRVLPEVEVQQKMKKKEKKAKKKAAQ--APEDAAEDAGTPAV----TRT H_sapiens_ENSP00000331815 -------------------FESVEAAVLLP--EEP-VSQLGVK-----------SPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPP------------------GPGQELT-----HCT M_mulatta_ENSMMUP00000010429 -------------------FESVEAAVLLP--EEP-VSQLGVK-----------SSGLYFLTAGDQGILRVWEAASGQCVYTQARPP------------------GPGRELT-----HCT X_tropicalis_ENSXETP00000035244 ---------------------------------SSSVRTVSFS-----------QDGKWLISGSLDGWVSLWAWEAQVQLSHFKAHS---------------------GSTL-----TCS P_troglodytes_ENSPTRP00000001997 EDGAFET-D--EAPEDRILSCRKAGSIMRE--GRDRVVNLGVD-----------KTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKL--HSCKGEEEDPEVNV----EMS P_pygmaeus_ENSPPYP00000007898 -------------------FESVEAAVLLP--EEP-VSQLGVK-----------SPGLYFLTAGDQGTLRVWEAASGQCVYTQARPP------------------GPGRELT-----HCT M_musculus_ENSMUSP00000046830 -------------------FESVEASVLLP--EQP-APALGVK-----------SSGLHFLTAGDQGILRVWEAASGQCVYTQPQMP------------------GLRQELT-----HCT R_norvegicus_ENSRNOP00000018405 -------------------FESVEASVLLP--EEP-ALALGVK-----------NSGLHFLTAGDQGILRVWEAASGQCVYTQPQMS------------------GLRQELT-----HCT A_aegypti_AAEL004526-PA -------------------YESLESVIVLP--KGVHLPGLKLK-----------SDKVYAACAGEEGLIKVWEMTETKIVFKQKNSL------------VTKSAEEGGLAIT-----DLL P_pygmaeus_ENSPPYP00000001131 EDGAFET-D--EAPEDRILSCTKAGSIMRE--GRDRVVNLAVD-----------KTGRILACHGTDSVLELFCILSKEEIQKKMDKKMKKARKKAKL--HSCKGEEEDPEVNV----EMS P_troglodytes_ENSPTRP00000053800 -------------------FESVEAAVLLP--EEP-VSQLGVK-----------SPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPP------------------GQRRELT-----HCT M_mulatta_ENSMMUP00000011166 EDGTFEM-D--EAPEDRILSCRKAGSIMRE--GRDRVVNLAVE-----------KTGRILACHGTDSVLELFCILSKEEIKKKMDKKMKKARKKAKL--HSCKGEEEDPEVNV----EMS R_norvegicus_ENSRNOP00000026726 EDRTLEADD--EKSEDRILSCRKAGSLMRE--GRDRVVNLAVD-----------KTGRILACHGTDSVLEVFCILSKAEVQKKMDKKLKKARKKARL--NSAN-EEEDPETSV----SMT O_anatinus_ENSOANP00000015573 -------------------FESVETAVLLP--EGPDFSALGVK-----------SGGLHFLTAGSRGLLCVWAAASGACVHRQEQPHPSGPGLP---ANDRRGEAEAGRSLT-----HCV T_guttata_ENSTGUP00000013749 EDETLEV-D--EHPEERIVKCSKVGSIMRE--GRDRVVTLGTD-----------RMGKFLAVHGTDTVLEVFSVLSEEEIQKKLGKKLKKARKKAKQ------NSEEEPERSV----ELS C_familiaris_ENSCAFP00000028736 -------------------FESVEAAVLLP--EEL-VPKLDVK-----------SKGLHFLTAGDQGLLRVWEAASGQCVYAQPQPP------------------GPRQGLT-----HCT X_tropicalis_ENSXETP00000015707 -------------------YESVEAVVLFP--DSSDIICQEND-----------SQSLLFLTAGSKGILRVWDAATAVCVYGQTLPHIA--------EGNSTEEEANEHSLT-----HCL E_caballus_ENSECAP00000009299 --------------------------------PGASVRTLAFN-----------VPGQVVAVGRLDRMVELWAWKEGARLAAFPAHH---------------------GFVA-----AAL M_domestica_ENSMODP00000006461 ETGDPGV-D--EDPEDRILSCNKAGSIMRE--GRDRVVNLAID-----------RTGRILACHGTDSILEVFCILSKEEIQKKMDKKIKKARKKAKL--SSGEGEQEDSGVSV----VMS M_musculus_ENSMUSP00000006444 --------------------------------PGPSVCSLAFN-----------KPGKIVAVGRIDGTVELWAWQEGARLAAFPAQC---------------------GCVS-----AVL H_sapiens_ENSP00000308179 EDGAFET-D--EAPEDRILSCRKAGSIMRE--GRDRVVNLAVD-----------KTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKL--HSSKGEEEDPEVNV----EMS T_rubripes_ENSTRUP00000006345 EDEA----D--EGPEERILSCKKVGSILRE--ARDRVVSLAAD-----------ARTGVIACHGNDSILEVFRVLPEAEVQQKMKKKEKRARKKAAR--AQEETGEDAGELTV----KRT E_caballus_ENSECAP00000017445 -------------------FESVEAAVTLP--EEP-APELGVK-----------STGLHFLTAGDQGMLRVWEAASGQCVYTQPQLP------------------GPGRELT-----HCA 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 2280 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 FSPDGSSFLTASDDQTI--------RVWETKKVCKNS----AIVLKQEIDVVFQENETMVLAVDNIRGL-QLIAGKTGQIDY------------------LPEAQ---VSCCCLSP-HLE E_caballus_ENSECAP00000022364 FSPDGSSFLTSSDDETI--------RLWETKKVCKNS----GIVLKQEIDVLFQENEVMILAVDNMRRL-QLINGKTGQIDY------------------LTEAQ---VSSCCLSP-HLQ B_taurus_ENSBTAP00000028867 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----ATVLKQEIDVVFQENEVTVLAVDNIRRL-QLINGNTGQIDY------------------LTEAQ---VSCCCLSP-HLQ P_troglodytes_ENSPTRP00000042795 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AVMLKQEVDVVFQENEVMVLAVDHIRRL-QLINGRTGQIDY------------------LTEAQ---VSCCCLSP-HLQ P_pygmaeus_ENSPPYP00000005543 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AVMLKQEVDVVFQENEVMVLAVDHIKRL-QLINGKTGQIDY------------------LTEAQ---VSCCCLSP-HLQ H_sapiens_ENSP00000353059 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AVMLKQEVDVVFQENEVMVLAVDHIRRL-QLINGRTGQIDY------------------LTEAQ---VSCCCLSP-HLQ R_norvegicus_ENSRNOP00000010869 FWMTDSTQLFLVPLSLT--------QVWETRKVCKNS----AIVLKQEIDVVFQENEMMVLAVDNIRGL-QLIAGKTGQIDY------------------LPEAQ---VSCCCLSP-HLE M_mulatta_ENSMMUP00000038848 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AIMLKQEVDVVFQENEVMVLAVDHIRRL-QLINGKTGQIDY------------------LTEAQ---VSCCCLSP-HLQ C_familiaris_ENSCAFP00000009806 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AIVLKQEIDVVFQENEVMVLAVDNIKRL-QLINGKTGQIDY------------------LIEAQ---VSCCCLSP-HLQ O_anatinus_ENSOANP00000008896 FSPDGSSFLTSSDDQTI--------RVWDTSKVCKNS----AVMLKQEIDVVFRDNEVMVLAVDSLRHL-QLINGKTGQTDY------------------LTEAQESLICCCCLSP-TLI M_domestica_ENSMODP00000009538 FSPDGSSFLTSSDDQTI--------RLWETRKVCKNS----AIMLKQEVDVAFRDDEVMVLAIDNIRRL-QLINGKTGHTDY------------------LTEAHKSRISCCCLSP-GLR T_guttata_ENSTGUP00000009081 FSPDGSLFLTSSDDQTI--------RIWETKKVCKSS----DAVLKSELDVVFHNGEVMILAIYNQKNL-QLINGNTDNVIM------------------QTAAQESPISCCCLSE-DLK G_gallus_ENSGALP00000037436 FSSDGSLFLTSSEDQTI--------RIWETNKVCKSS----DAVLKSELDVVFHNGEVMILAIYNQKHI-QLINGNTDSIIM------------------QTEPQESLICCCCLSE-DLK A_carolinensis_ENSACAP00000012965 FSFDGSLFLTSSDDQTI--------RIWETSKVCNFS----AIVLNREIDVLFLDSDVIILAIDSSKRL-QLISGYTGNTIY------------------LTKEQDSLICCCCLSH-DRK X_tropicalis_ENSXETP00000014654 FSPKSSSFLTSSDDQTV--------KLWETSNVSKPA----ATNLKREFDVTFSGERTLVLATSKDDCI-LLINGMTGETLS------------------QIRAQDNCVTCCCLST-DYQ G_gorilla_ENSGGOP00000008216 FSPDGSSFLTSSDDQTI--------RLWETKKVCKNS----AVMLKQEVDVVFQENEVMVLAVDHIRRL-QLINGKTGQIDY------------------LTEAQ---VSCXXXXX-XXX D_rerio_ENSDARP00000008347 FSPDGSLLLSSSDDQTI--------RLWETDRVHTSS----AVALKRDTDVLFSHSDATIIAPDSSNRL-QVLSGSTGAVVL------------------ESEELSSRIRCSCISR-NAA O_cuniculus_ENSOCUP00000010200 FSPDGSSFLTSSDDQTI--------RVWETKKVCKNS----AIVLKQEVDVVFQENEVMVLAVDDVRCL-QLINGKTGQIDY------------------LTEAQ---VSCCCLSP-HLQ T_rubripes_ENSTRUP00000033561 FSPDGSQLLSCSDDHTV--------RLWETTKVHTSS----AVCLKRDSDVLFDQEEIIISAADNCNRL-QVRNGRTGSVLF------------------QSEEKSSRIRCTCLCR-QPP T_nigroviridis_ENSTNIP00000013938 FSTDGSQLLSCSDDQTI--------RLWETTKVHTSS----AICLKRDSDVLFDQEEIIISAADNCNRL-QVRSGKTGSVLF------------------QSEEKSSRIRSTCLCR-NPS G_aculeatus_ENSGACP00000026214 FSRDGSQLLSCSDDQTV--------RLWETNKVHTTS----AVCLKRDSDVLFNDEEIIVSAADNCNRLQQVRDGRTGSVLF------------------QSEEKPSRIRCTSMCR-QPS O_latipes_ENSORLP00000019346 FSRDGSQMLSCSDDETI--------RLWETKKLHMTS----AVFLKRNTDVLFNDDNIFVSAPDHCNRL-QV---RTGDTLL------------------QSEKKPSRIRCTCLLR-DLS C_elegans_Y45F10B.10 CAQDDCQLF-AATKSKV--------FCYDIHNGQMIDVLDTAQPFPICSLKISSDNYFLISPCGPKVTIWNVTKRNHDAHD-------------------VHADKEGFLTAVALSN-DDK C_intestinalis_ENSCINP00000010464 IEDEISHVGSFTCAGKL--------SSLDLTAPTPNTYNTVALLRNNQIETVSTISLLSQPEYSSLKRL-------------------------------SQLGHRTDTKSMCFT--MDG M_domestica_ENSMODP00000008927 FLQSGRQMLTAGEDGKV--------QMWSGSLGRPKGTL-DSLPLSPALSVAISPDRAFVAVGHHSDGI-RIYRTSSGTE--------------------EGQCPVSDAAVSALAWLNPK M_domestica_ENSMODP00000027702 LVPAAGLIMAVTAEHNI--------LLYDAHNLRLHK---------------------------------------------------------------QFAGYNEDVLDVRFLGPEDS T_nigroviridis_ENSTNIP00000004057 LLPASLRLATVTAEHNI--------MLYQLPGLTTLQ---------------------------------------------------------------QFVGYSDEVLDVKFLGKDDS T_guttata_ENSTGUP00000006840 ----QNEILTVSMEHNI--------VFYDAHSLQLRK---------------------------------------------------------------QLTGYNEEVLDVKFLGPGDS B_taurus_ENSBTAP00000001564 FLRSGCQLLTAGEDGKV--------QVWSGSLGRPRGCL-GSPHLSPALSVALSPDGDQVAVGYRADGI-RICRISSASQ--------------------GAQGQALDVAVSALTWLSPK H_sapiens_ENSP00000262715 FLHAGCQLLTAGEDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGI-RIYKISSGSQ--------------------GAQGQALDVAVSALAWLSPK C_intestinalis_ENSCINP00000019387 LIPDTNKMVAVTFDHCI--------DCLDMNGLVVNK---------------------------------------------------------------QMVGYNDEIVDLKLLGKNDS G_gallus_ENSGALP00000008904 LVPERNEIVTVSVEHNI--------VFYDAQTLQLRK---------------------------------------------------------------QLAGYNDEVLDVKFLGPGDS P_troglodytes_ENSPTRP00000010340 FLHAGCQLLTAGEDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGI-RIYKISSGSQ--------------------GAQGQALDVAVSALAWLSPK S_cerevisiae_YLR222C PILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTS---------------------------------------------------------------SIAGNHGIIADMRYVGPELN G_aculeatus_ENSGACP00000015863 LLPASSRLATVTADHNI--------VLYQLPALTTQQ---------------------------------------------------------------QFVGYNDEVLDVKFLGKGDS B_taurus_ENSBTAP00000027147 LAHAAGLLLSVTADHNL--------LLYDAHSLRLRK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS A_gambiae_AGAP009615-PA YSEPHGRMAVVSADHNI--------LVHDCESFDYVH---------------------------------------------------------------QLSGFSDEILDLILFGKRDQ D_rerio_ENSDARP00000023281 LKDEIMKLANIRASSKI--------RSMDCLLVPNGEMKVVLLLQNNTVETYTLKTTEKNPTGNKTSRL-------------------------------TLGGHRSDVRTVAFS--SDN T_rubripes_ENSTRUP00000017221 LLPASSRLATVTAEHNI--------TLYQLAGLTTLQ---------------------------------------------------------------QFVGYNDEVLDVKFLGKDDS A_gambiae_AGAP004827-PA IAMDSQRAIVGGEDTRA--------LIFDMHSGRVIRSL-PPNPGAVTAVYVMEKDDYLITAGGNKITFYSFRNEDSIVNFY---PKKKKTLKKFHRNRLALQSTSSPVICFDVS--RDS A_aegypti_AAEL001276-PA IAMDSQRAIVGGEDTRA--------LIYDMHSGRIIRSL-PPNPGPVTAVYIMAKDDYLITAGGNKITFYSFRNEDSIVNFF---PKKKKTMKKIAKSRVALAATSSPVICFDIS--RDS M_mulatta_ENSMMUP00000021364 FLHAGCQLLTAGEDGKV--------HVWSGSLGRPRGDL-GSLPLSPALSVALSPDGDRVAVGYRADGI-RIYKISSGSQ--------------------GAQGQALDVAVSALAWLSPK P_pygmaeus_ENSPPYP00000006332 FLHAGCQLLTAGEDGKV--------QVWSGSLGRPRGLL-GSLSLSPALSVALSPDGDQVAVGYRADGI-RIYKISSGSQ--------------------GAQGQALDVAVSALAWLSPK O_anatinus_ENSOANP00000004860 LQDQIRRMVNVKASAKI--------KSFDLIRGPRGEVKAALLLQNNQVELVSVTPAQPVPQVVRGAQI-------------------------------STGGHRTDVRTLSFS--SDN D_melanogaster_FBpp0085899 IGKDSQRCVVGCDDTRA--------LIYDMHAGKLVRSL-PPNPGPVTAVHAMDNDDFLVTVGGNKITFYSFRNEELYVNPYSRHPRRKRSLKRHAQAQRSPSTTLPPITCFDLS--RDS O_latipes_ENSORLP00000010395 LKDEIVRLTNIKASAKI--------RWADCLSGAGGELKVALLLQNNTVETYSLKTSDENPSANKTARL-------------------------------TLGGHRTDVRTLAFS--SDN R_norvegicus_ENSRNOP00000012235 FLHAGGRFLTAGEDGKA--------QLWSGFLGRPRGCL-GSLYLSPALSVALNPDGDQVAVGYRGDGI-KIYRISSGPQ--------------------EAQCQELNVAVSALVWLSPS S_cerevisiae_YCR057C FHPATRLLAVGFTSGEF--------RLYDLPDFTLIQ---------------------------------------------------------------QLSMGQNPVNTVSVNQ-TGE G_gorilla_ENSGGOP00000009169 LAHTAGVVLTATADHNL--------LLYEARSLRLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS T_nigroviridis_ENSTNIP00000007980 LKDEIVRLTNIKASAKI--------RWAECVWCSGGELKVALLLQNNTVETYSLRTADKTPAGTKTARL-------------------------------TLGGHRTDVRTLAFS--SDN H_sapiens_ENSP00000331815 LAHTAGVVLTATADHNL--------LLYEARSLRLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS M_mulatta_ENSMMUP00000010429 LARTAGLLLSATADHNL--------LLYEARSLRLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS X_tropicalis_ENSXETP00000035244 FLQQGKYLLTGGEDSKV--------QVWSGGLGRLLGRVDGEIKNSSAISLAVSPSRQLLAVGYHTGTV-SVYSVDLGDL--------------------VAQTSIEDVTILCVAWLSEE P_troglodytes_ENSPTRP00000001997 LQDEIQRVTNIKTSAKI--------KSFDLIHSPQGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRI-------------------------------TIGGHRSDVRTLSFS--SDN P_pygmaeus_ENSPPYP00000007898 LARTAGLVLTTTADHNL--------LLYEARSLRLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS M_musculus_ENSMUSP00000046830 LARAADLLLTVTADHNL--------LLYEAHSLQLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPSDS R_norvegicus_ENSRNOP00000018405 LARAAGLLLTVTADHNL--------LLYEARSLQLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPNDS A_aegypti_AAEL004526-PA FNKQSSKLAIVSADHNI--------IIHDLETFECSK---------------------------------------------------------------QLSGFSDEILDLILFGKKDH P_pygmaeus_ENSPPYP00000001131 LQDEIQRVTNIKTSAKI--------KSFDLIHSPQGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRI-------------------------------TIGGHRSDVRTLSFS--SDN P_troglodytes_ENSPTRP00000053800 LAHTP-VVLTATTDHNL--------LLYEAHSLRLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS M_mulatta_ENSMMUP00000011166 LQDEIQRVTNIKTSAKI--------KSFDLIHSPQGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRI-------------------------------TIGGHRSDVRTLSFS--SDN R_norvegicus_ENSRNOP00000026726 LQDEILRVTKIKTSAKI--------KSFDLIHSPQGELKAVFLLQNNLVELYSLSTSLPNPQPVRTSRI-------------------------------TIGGHRSDVRTLSFS--SDN O_anatinus_ENSOANP00000015573 LVPAAGLVATVTAEHNI--------LLYDALTLRLRK---------------------------------------------------------------QFAGHNDEVLDVRFLGPDDS T_guttata_ENSTGUP00000013749 LQEEIQRVTNVKASSKI--------KSFDLILSPKGELKMVLLLQNNIIELYNLDLSAQVTQAVRVSRI-------------------------------TIGGHRSDVRTLAFS--SDN C_familiaris_ENSCAFP00000028736 LAQSAGLLLSVTTDHNL--------LLYEARSLQLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS X_tropicalis_ENSXETP00000015707 LIPGQHQVATVTAEHNI--------LMYDLQNLQLKK---------------------------------------------------------------QFAGYNDEVLDVKFLGPSDS E_caballus_ENSECAP00000009299 FLRAGCQLLTAGEDGKV--------QVWSGSLGRPRGCL-GSLSLSPALSVALSPDGDRVAVGYRADGI-RIYKISSGSQ--------------------GAQCQALDVAVSALAWLGPK M_domestica_ENSMODP00000006461 LQDEIQRVANIKASAKI--------KSFDLIHSPHGGLKAVFLLQNNLVEVYTLNPSTPAPQPIRTARI-------------------------------TIGGHRSDVRTLSFS--SDN M_musculus_ENSMUSP00000006444 FLHAGDRFLTAGEDGKA--------QLWSGFLGRPRGCL-GSLPLSPALSVALNPDGDQVAVGYREDGI-NIYKISSGSQ--------------------GPQHQELNVAVSALVWLSPS H_sapiens_ENSP00000308179 LQDEIQRVTNIKTSAKI--------KSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRI-------------------------------TIGGHRSDVRTLSFS--SDN T_rubripes_ENSTRUP00000006345 LKDEITRLTHIKASAKI--------RWAECLSCPGGELKVALLLQNNTIETYSLKAASTTPTSNKTARL-------------------------------TLGGHRTDVRTLAFS--SDN E_caballus_ENSECAP00000017445 LARAAGLLLSVTADHNL--------LLYEACSLQLQK---------------------------------------------------------------QFAGYSEEVLDVRFLGPEDS 2290 2300 2310 2320 2330 2340 2350 2360 2370 2380 2390 2400 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 YVAFGD-EDGAIKIIE-LPNNRV-----------------------------------------------------FSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQV-WNWQTGD-- E_caballus_ENSECAP00000022364 YVALGG-EDGAIKILE-LLNNRI-----------------------------------------------------FQSKIGHKSAVRHVQFTTDGKTLISSSDDSVIQV-WNWQSEE-- B_taurus_ENSBTAP00000028867 YLAFGG-EDGAIQILE-LLNNRI-----------------------------------------------------FQSRNGHKTTVRHIQFTADGKTLISSSDDSAVQI-WNWQSED-- P_troglodytes_ENSPTRP00000042795 YIAFGD-ENGAIEILE-LVNNRI-----------------------------------------------------FQSRFQHRKTVWHIQFTADEKTLISSSDDSEIQV-WNWQLDK-- P_pygmaeus_ENSPPYP00000005543 YIAFGD-ENGAIEILE-LVNNRI-----------------------------------------------------FQSRFQHKKTVWHIQFTADEKTLISSSDDSEIQV-WNWQLDK-- H_sapiens_ENSP00000353059 YIAFGD-ENGAIEILE-LVNNRI-----------------------------------------------------FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQV-WNWQLDK-- R_norvegicus_ENSRNOP00000010869 YVAFGD-EEGAIKVLS-STNSRV-----------------------------------------------------QSAKNFHLKAFLHYRFTRICKERIESCENCSVFG-VEWQTEE-- M_mulatta_ENSMMUP00000038848 YIAFGD-ENGTIEILE-LVNNRI-----------------------------------------------------FQSRIRHKKTVWHIQFTADEKTLISSSDDSAIQV-WNWQLEE-- C_familiaris_ENSCAFP00000009806 YIAFGG-EDGAVEILE-LLNNRI-----------------------------------------------------FQSRIGHKKTVRHIQFTDDGKTLISSSDDSSIQV-WNWQSEE-- O_anatinus_ENSOANP00000008896 SLAFGE-EDGTVKILE-LPNGRM-----------------------------------------------------FKSKIKHKKPVQHCRFTSDGKTVISSSDDPVIQV-WIWQTEE-- M_domestica_ENSMODP00000009538 FVAFGE-EDGSIKILE-LPNGRE-----------------------------------------------------FRSRIGHEKAVRRVQFTPDGRTLISSSDDSTVQV-WNWQSEE-- T_guttata_ENSTGUP00000009081 FAAFGQ-ESGTIKVLQ-LSDGKV-----------------------------------------------------LKSWEAYRTSVQHCRFTPDCQTLISSAHDPVIQV-WNWQLSE-- G_gallus_ENSGALP00000037436 FAAFGQ-ENGAIKVLR-LLDGRV-----------------------------------------------------LTSREAYRTSVQHCRFTTDCQTLISSAHDAVIQV-WNWQLNE-- A_carolinensis_ENSACAP00000012965 VAAFGE-NNGTVKVLS-LQNGNT-----------------------------------------------------LNSRTGHREAVQHCQFTSDGKTLISSSDDSTIQV-WNWQSEE-- X_tropicalis_ENSXETP00000014654 LAAIGH-RDGKVKILD-LSGGEI-----------------------------------------------------LHKLDGHRDTVQHCQFTADGKLLVSSSDDCTVRV-WNLVSGK-- G_gorilla_ENSGGOP00000008216 XXXXXX-XXXXXXXXX-XXXXXX-----------------------------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXV-WNWQLDK-- D_rerio_ENSDARP00000008347 FVALGS-EDGTVQVIE-VPSSKA-----------------------------------------------------SVKLSGHTKTVHHCQFTDDCEILITSSEDSTIRV-WKWRTGE-- O_cuniculus_ENSOCUP00000010200 YIAFGD-EDGTIEILE-LLNSRI-----------------------------------------------------FQSRIGHKKTVRHIQFTADGKTLISSSDDSAIQ----------- T_rubripes_ENSTRUP00000033561 AVVIGQ-EDGTVQVLE-LPTGKV-----------------------------------------------------LATLLGHTKTVFCCQFSQDGQTLITSSEDTTIRV-WRWLSGE-- T_nigroviridis_ENSTNIP00000013938 AVVIGQ-ENGTVQVLE-LPTGKV-----------------------------------------------------LATLLGHTKTVFWCQFSQCGETLFTSSEDTTIRV-WRWRSGE-- G_aculeatus_ENSGACP00000026214 AVALGQ-EDGTVQVLQ-VPSGNL-----------------------------------------------------LATLLGHTKTVLHCRFSQSGKTLLTSSEDTTIRKNWFLRPFQ-- O_latipes_ENSORLP00000019346 VVALGQ-EDGTVQVLA-VPSAKP-----------------------------------------------------LATLLGHTKTVLHCQFTHYGQTLITSSEDCTIRV-WNLPSGE-- C_elegans_Y45F10B.10 YAACGT-NNGIVALWD-LEVCQC----------------------------------------------------VFTTIQNKGDPITCIRYSVDSQYCISGNQAGCILI-LDAQNGG-- C_intestinalis_ENSCINP00000010464 MALLTT-SSESAKLWN-RSSHQC-------------------------------------------------------IRTLKCSHPKCCLFVPGDRQVILGTQEGALEL-HDVASGT-- M_domestica_ENSMODP00000008927 VLVSGG-EDGNLQCWM-LAYVTPHRLWLLPAHQKAVLGLATSQELLASASAEDFTVRLWSLQFLTQPNL-AKKLHPGRELRGHTGPVTCCSFSPDGGILATGSRDQSLLC-WDVRMPEAP M_domestica_ENSMODP00000027702 HIVVAT-NSPRLKVFE-LETSDC------------------------------------------------------QILCGHTDIVLALDVFRKGRLFTSCAKDQSVRI-WRMNA-TGK T_nigroviridis_ENSTNIP00000004057 HIVVAT-NSCQLNVFE-LASNSC------------------------------------------------------QILYGHTDTILSLDVFRKGLLFASCGKDKLVCV-WHMA--GGS T_guttata_ENSTGUP00000006840 HIVVAT-NSPQLKVFE-LATSHC------------------------------------------------------QILYGHTETILALDVFRKGLMFVTCAKDRSMRV-WRMGQ-AGR B_taurus_ENSBTAP00000001564 VLVSGA-EDGALQGWL-LQGGTLQSLWLLSRHRKPVLGLATSQELLAIAS-EDFTVRLWPRQLLMLPQK-TEDFPRSTELRGHEGPVSCCSFSTDGCRLATGGRDRSLLC-WDVRTPKAP H_sapiens_ENSP00000262715 VLVSGA-EDGSLQGWA-LKECSLQSLWLLSRFQKPVLGLATSQELLASAS-EDFTVQLWPRQLLTRPHK-AEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC-WDVRTPKTP C_intestinalis_ENSCINP00000019387 HIIVVT-NSPHIKVFN-MKTSAC------------------------------------------------------QVLKKHSDTVLCVDVFKNRTHFVSSSKDNTVCL-WRMEENTYA G_gallus_ENSGALP00000008904 HIVVAT-NSPQLKVFE-LSTSHC------------------------------------------------------QILYGHTETILALDVFRKGLMFVSCAKDKSIRV-WRMNK-DGR P_troglodytes_ENSPTRP00000010340 VLVSGA-EDGSLQGWA-LKECSLQSLWLLSRFQKPVLGLATSQELLASAS-EDFTVQLWPRQLLMRPHK-AEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC-WDVRTPKTP S_cerevisiae_YLR222C KLALAT-NSPSLRIIP-VPDLSGPE---------------------------------------------ASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIV-WRYNENSCK G_aculeatus_ENSGACP00000015863 HIVVAT-NSCQLKVFE-LLTNSC------------------------------------------------------QILYGHTDTVLSLDVFKKGFVFASCAKDRSVRV-WQMDSDSGR B_taurus_ENSBTAP00000027147 HVVVAS-NSPCLKVFD-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGRLFASCAKDQSIRV-WRMNK-SGE A_gambiae_AGAP009615-PA HIAMAT-NSSDFKVYD-VSTMNC------------------------------------------------------RLVKGHTDIVLSLCANDR--YLLSSSKDNSIRL-WSFTEEPFT D_rerio_ENSDARP00000023281 IAILSA-SGDTVKVWN-RSTLQV-------------------------------------------------------IRTMGCEYALCSIFVPGDRQIILGTKSGKIQI-FDLASGS-- T_rubripes_ENSTRUP00000017221 HIVVAT-NSCQLKVFE-LLTNSC------------------------------------------------------QILYGHTDTVLSLDVFRKGSLFASCAKDRSVCV-WQMD--SGH A_gambiae_AGAP004827-PA TMAAVA-SSRCVQIWQ-LNSPEL-----------------------------------------------------TSILEGHSATVTCVSFAPNCELVASGSEDKTVNV-WSLGLGT-- A_aegypti_AAEL001276-PA TTAAVA-SSRCIQIWQ-LNTPEL-----------------------------------------------------TAILEGHTGTVTCVSFAPNCEFVASGSEDKTVNV-WSLALGT-- M_mulatta_ENSMMUP00000021364 VLVSGA-EDGSLQGWA-LKECSLQSLWLLSRFQKPVLGLATSQELLASAS-EDFTVRLWPRQLLTLPHK-AEDFPGGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC-WDVRTPKAP P_pygmaeus_ENSPPYP00000006332 VLVSGA-EDGSLQGWA-LKECSLQSLWLLSRFQKPVLGLATSQELLASAS-EDFTVRLWPRQLLTRPHK-AEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLC-WDVRTPKTP O_anatinus_ENSOANP00000004860 IAVLSA-SAESVKIWNSRSTLQC-------------------------------------------------------IRTLACEYALCSLFVPGDRQVIVGTKKGKLQL-YDLASAS-- D_melanogaster_FBpp0085899 QQMAIA-SGRHVHLMR-INTPEY-----------------------------------------------------QCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHI-WNLALGE-- O_latipes_ENSORLP00000010395 LAVLSA-SGDTVKVWN-RSTLQV-------------------------------------------------------IRTMTCEYALCSLFVPGDRQIILGTKSGKLQI-FELASGS-- R_norvegicus_ENSRNOP00000012235 VLVSGA-EDGSLHGWM-LRRNSLQSLWLSSVCQKPVLGLAASQEFLASAS-EDFTVRLWPRQLLTQPHA-VEELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLC-WDVKVAQAP S_cerevisiae_YCR057C WLAFGSSKLGQLLVYE-WQSESY-----------------------------------------------------ILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV-WDITSGF-- G_gorilla_ENSGGOP00000009169 HVVVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSVRI-WRMNK-AGQ T_nigroviridis_ENSTNIP00000007980 LAVLSA-SGDTVKVWN-RATLQV-------------------------------------------------------IRTMACEYALCSLFVPGDRQIVLGSESGKLQI-FELASAA-- H_sapiens_ENSP00000331815 HVVVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSVRI-WRMNK-AGQ M_mulatta_ENSMMUP00000010429 HVIVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSVRI-WRMNK-AGQ X_tropicalis_ENSXETP00000035244 VLVTGT-SDSLVRVWK-ISSGQFTCQLMLKEHQRFVQALAVSSKLLASAS-GDVSVCLWSLNSLLNS---VSPPSPASVLQGHSAAVTCCSFSRNGKLLATGSQDRSVLC-WDVSLIP-P P_troglodytes_ENSPTRP00000001997 IAVLSA-AADSVKIWN-RSTLQC-------------------------------------------------------IRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL-YDLASGN-- P_pygmaeus_ENSPPYP00000007898 HVVVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSVRI-WRMNK-AGQ M_musculus_ENSMUSP00000046830 HIVVAS-NSPCLKVFE-LQTLAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSIRI-WKMNK-AGQ R_norvegicus_ENSRNOP00000018405 HIIVAS-NSPCLKVFE-LQTLAC------------------------------------------------------QILHGHT-IVLALDVFRKGWLFASCAKDQSIRI-WRMNK-AGQ A_aegypti_AAEL004526-PA FLGMAT-NSNDFKIYD-TTNMNC------------------------------------------------------QLVKGHTDIVLSLSANQN--YILSSSKDNSIRL-WRYDTAKFT P_pygmaeus_ENSPPYP00000001131 IAVLSA-AADSIKIWN-RSTLQC-------------------------------------------------------IRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL-YDLASGN-- P_troglodytes_ENSPTRP00000053800 HVVVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSVRI-WRMNK-AGQ M_mulatta_ENSMMUP00000011166 IAVLSA-AADSIKIWN-RSTLQC-------------------------------------------------------IRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL-YDLASGN-- R_norvegicus_ENSRNOP00000026726 IAVLSA-AAESVKIWN-RSTLQC-------------------------------------------------------IRTMPCEYALCSFFVPGDRQVVIGTKTGNMQL-YDLASGN-- O_anatinus_ENSOANP00000015573 HIVVAT-NSPQLKVFE-LATSSC------------------------------------------------------QILYGHTDTVLALDVFRKGRLFASCGKDHSVRL-WKLGK-AGA T_guttata_ENSTGUP00000013749 IAILSA-AAESVKIWN-RSTLQC-------------------------------------------------------IRTMECEYALCSLFVPGDRQVIIGTKTGKLQL-YDXXXXX-- C_familiaris_ENSCAFP00000028736 HIVVAS-NSPSLKVFE-LQTMTC------------------------------------------------------QILHGHTDIVLALDVFRKGRLFASCAKDQSICI-WRMNK-AGR X_tropicalis_ENSXETP00000015707 HIVVAT-NSPQLKVFD-LETSNC------------------------------------------------------QILYGHTETVLALDVFKKGLLFASCAKDRTIRV-WRMKKATGK E_caballus_ENSECAP00000009299 VLVSGA-EDGSLQGWA-LKESSLQSLWLLSRYQRPMLGLATSQELLASAS-EDFTVRLWPRQLLTLPQK-AEDFPCATELRGHEGPVSCCSFSTDGGSLATGGRDRNLLC-WDVRTPKAP M_domestica_ENSMODP00000006461 IAILSA-AADSVKIWN-RSTLQC-------------------------------------------------------IRTMACEYALCSLFVPGDRQVIIGTKTGKLQL-YDLASGN-- M_musculus_ENSMUSP00000006444 VLVSGA-EDGSLHGWM-FKGDSLHSLWLLSRYQKPVLGLAASRELMAAAS-EDFTVRLWPRQLLTQPHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLC-WDMKIAQAP H_sapiens_ENSP00000308179 IAVLSA-AADSIKIWN-RSTLQC-------------------------------------------------------IRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL-YDLASGN-- T_rubripes_ENSTRUP00000006345 LAVLSA-SGDTIKVWN-RATLQV-------------------------------------------------------IRTMACEYALCSLFVPGDRQIILGTKSGKLQI-FELASGS-- E_caballus_ENSECAP00000017445 HVVVAS-NSPCLKVFE-LQTSAC------------------------------------------------------QILHGHTDIVLALDVFRKGWLFASCAKDQSIRI-WRMNK-AGK 2410 2420 2430 2440 2450 2460 2470 2480 2490 2500 2510 2520 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ---YVFLQAHQETVKDFR----LLQDS----RLLSWSFDGTV-KVWNVITGRIER---------------------------------------------DFTCH-QG-TVLSCAISSDA E_caballus_ENSECAP00000022364 ---YVFLQAHQEAVKDFR----LLRNS----RLLSWSFDGTV-KVWNIITGRIEK---------------------------------------------DFVCH-QD-TVLSCDISPDA B_taurus_ENSBTAP00000028867 ---PFFLQAHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITRRIEK---------------------------------------------DFVCH-QD-TVLSCDISSDA P_troglodytes_ENSPTRP00000042795 ---CIFLRGHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITGNKEK---------------------------------------------DFVCH-QG-TVLSCDISHDA P_pygmaeus_ENSPPYP00000005543 ---YIFLRGHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITGNTEK---------------------------------------------DFVCH-QG-TVLSCDISHDA H_sapiens_ENSP00000353059 ---CIFLRGHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITGNKEK---------------------------------------------DFVCH-QG-TVLSCDISHDA R_norvegicus_ENSRNOP00000010869 ---YVFLQAHQETVKDFR----LLRDS----RCFPGSFDGTV-KVWNVITGRIER---------------------------------------------DFTCH-QG-TVLSCAISSDA M_mulatta_ENSMMUP00000038848 ---YVFLQAHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITGKIEK---------------------------------------------DFVCH-QG-TVLSCDISHDA C_familiaris_ENSCAFP00000009806 ---YVFLQAHQETVKDFK----LLKNS----KLLSWSFDGTVKKIWSIITGRIEK---------------------------------------------DFVCH-QD-TVLSCDISPDA O_anatinus_ENSOANP00000008896 ---YVFLQAHQESVKDFR----LLQNS----RLFSWSFDGTI-KVWNILTGKVEK---------------------------------------------DFFCH-QG-AVLSCNISPDA M_domestica_ENSMODP00000009538 ---FVFLKAHQEPVKDFR----LLQNS----RLLTWSFDGTV-KVWNILTGKVEK---------------------------------------------DFTCH-QG-TVLSCDVSPNA T_guttata_ENSTGUP00000009081 ---CVFLRGHNEAIKDFR----LLENS----KILSWSFDGTV-KVWNITTGNPER---------------------------------------------DFACH-RD-AVLSCAVSPDG G_gallus_ENSGALP00000037436 ---CVFLKGHKEAIKDFA----FLENS----KLLSWSFDGTV-KVWNITTGKTEK---------------------------------------------DFACH-RG-AVLSCAVSPDG A_carolinensis_ENSACAP00000012965 ---CILLKGHNERVKKFL----LLKDS----RLLSWSFDGTV-KLWNIVTGEIEK---------------------------------------------DVICH-EN-AILSCAISPDA X_tropicalis_ENSXETP00000014654 ---NLELCGHKEPVKFFK----ILQES----KVFSWSFDGTV-KVWNLLTGQLIK---------------------------------------------EFICH-SA-TVLACDISPDS G_gorilla_ENSGGOP00000008216 ---CIFLRGHQETVKDFR----LLKNS----RLLSWSFDGTV-KVWNIITGNKEK---------------------------------------------DFVCH-QG-TVLSCDISHDA D_rerio_ENSDARP00000008347 ---CMVLQGHMEPVRKFH----LLSSSSSP-RLFSWSFDGTV-KVWDLTRGQMLQ---------------------------------------------DLVCH-EG-AVLSCDVSSDG O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ---CKVLQGHREQVRCFT----LLSSSPSKMRLLSWSFDGTV-KMWDTESGEKLQ---------------------------------------------DVEAH-QG-AILSCHVSPDG T_nigroviridis_ENSTNIP00000013938 ---CKTLLGHREQVRHFS----LLSSSPSDTRLLSWSFDGTV-KMWDTESGEKLQ---------------------------------------------DMEAH-QG-AILSCHVSPDG G_aculeatus_ENSGACP00000026214 ---KGKAVLSFSPFLSFE----INNPTTGG---------GAF-CWLGGGVSSRMR---------------------------------------------AWGFH-EG-RLRQIRVGGGG O_latipes_ENSORLP00000019346 ---CKVLQGHKEQVRCFA----LLSPSSNDSRLLSWSFDGTV-KVWNTESGQKLQ---------------------------------------------DIDAH-GG-AILSCHVSPDG C_elegans_Y45F10B.10 --VVRELFMHSSEVLSIM----SLVHN----KMISCDIQGKM-VIWELFGDDDTPEMVATGVKPPIFVPPTGRIMVGHCSLSNKEMKIWAFPEEGPPVTRAKLSH-SD-EITCFATSPKG C_intestinalis_ENSCINP00000010464 --LLETIQAHEGAVSCVA----LFPNKR---GIVSGGPDKKI-KFWEFDLISDEN----YSVS-SKRV----------------------------SLTHTRTFELDD-QILDVEFTPNN M_domestica_ENSMODP00000008927 VVMHSLPACHRDWVTGCS----WTKDA----MLLSCSNDGSV-RLWDPVSGQQLG---------------------------------------------QFLGH-QS-AVSTVVAVEEH M_domestica_ENSMODP00000027702 VHCIAHGSGHTHSIGTIS----CSRLKET--FLVTGSQDCTI-KLWPLPEPITSKKMTKNPNCDPFPL----------------------------QAQATQRAH-DK-DINSVAVSPND T_nigroviridis_ENSTNIP00000004057 VRCVARGYSHTNAVGAVS----CSRMKAS--FVVSGSLDCTV-KVWDLPADLTAA------EDNIHQL----------------------------TPRATEKAH-DK-DVNSVTVSPND T_guttata_ENSTGUP00000006840 VTCVAHAQSRFPALGGLI----PLRLKES--FVVTSSQDCTI-KIWNIPESLTSKAKAAL-ISSPEPL----------------------------HARVTERGH-DK-DINSVAVSPND B_taurus_ENSBTAP00000001564 VLICSFSACHRDWVTGCA----WTKDS----LLVSCSSDGSV-ALWDPESRQQLG---------------------------------------------HFLGH-QH-AVSAVVAVEEH H_sapiens_ENSP00000262715 VLIHSFPACHRDWVTGCA----WTKDN----LLISCSSDGSV-GLWDPESGQRLG---------------------------------------------QFLGH-QS-AVSAVAAVEEH C_intestinalis_ENSCINP00000019387 VTCLVVGAGHTHDVGAVT----CCNNKME--FLVSGSQDQTL-KIWTINETF--------------QL----------------------------RVKHTVMAH-SK-NINSIVVSPND G_gallus_ENSGALP00000008904 VVCVAQGLGHAHGVGAVS----CSRLKES--FVVTSSQDCTI-KVWNIPESLTSKAKAAL-ISGPETL----------------------------HAQMTERGH-DK-DINSVAVSPND P_troglodytes_ENSPTRP00000010340 VLIHSFPACHRDWVTGCA----WTKDN----LLISCSSDGSV-GLWDPESGQRLG---------------------------------------------QFLGH-QS-AVSAVAAVEEH S_cerevisiae_YLR222C FDIYAKYIGHSAAVTAVGLPNIVSKGYPE--FLLTASNDLTI-KKWIIPKPTASM------DVQIIKV-----------------------------SEYTRHAH-EK-DINALSVSPND G_aculeatus_ENSGACP00000015863 VHCVAHGSNHANAVGSIT----CSRMKAS--FVVSGSQDCTL-KVWDLPADLSTT------GGDLHHL----------------------------TPRATEKAH-DK-DVNSVAVSPND B_taurus_ENSBTAP00000027147 VACVAQGSGHTHSVGTIC----CSRLKET--FLVTGSQDCTV-KLWPLPEALLSKGTGH--EGGPVFL----------------------------QAQATQRCH-DK-DINSVAVAPND A_gambiae_AGAP009615-PA ISCVAIGLKHTNTVGCVT----LSRQGGN--FCASVSQDRCL-KTWKIPKKFTTEE-----DGELPRL----------------------------QCSLTALAH-EK-DINCVTISPND D_rerio_ENSDARP00000023281 --LLETTDAHEGALWSMC----LSPDQR---GIVTGGADKTV-KFWDFELIKDED------SMINKRL----------------------------TVKHTRTLQLDE-DVLCVRFSPDQ T_rubripes_ENSTRUP00000017221 VRCVARGTSHTNAVGCIS----CSRMKAS--FVASGSLDCTV-KVWDLPADLTAA------EESIQQL----------------------------TLRTTEKAH-DK-DVNSVAVSPND A_gambiae_AGAP004827-PA --VTATFKGHCTSISSVT----FMMDAR---RIISADRDGLL-YVWISDSGMILQ-------------------------------------------------SVQG-PHKCLSVTNNM A_aegypti_AAEL001276-PA --IVTTFKGHNTFVTSVT----FLMDSR---RIISADRESCL-FVWMADSGTILQ-------------------------------------------------SVQG-PFKCLAVTNNM M_mulatta_ENSMMUP00000021364 ILIHSFPACHRDWVTGCA----WTKDN----LLISCSSDGSV-GLWDPESGQRLG---------------------------------------------QFLGH-QS-AVSAVAAVEEH P_pygmaeus_ENSPPYP00000006332 VLIHSFLACHRDWVTGCA----WTKDN----LLISCSSDGCV-GLWDPESGQRLG---------------------------------------------QFLGH-QS-ALSAVAAVEEH O_anatinus_ENSOANP00000004860 --LLETVEAHAGAVWSIS----LSPDQR---GFVTGGADKTV-RFWDFHLVKDAD------GP-QKRL----------------------------SVGEARTLQLDE-EVLCVRYGPDR D_melanogaster_FBpp0085899 --ICNSFKGHTAPVVKVV----VLMDSL---RVISTDRDSML-LVWMAHSGNLLQ-------------------------------------------------TIQG-PYKSLSVTNNM O_latipes_ENSORLP00000010395 --LLETSDAHDGAVWSLC----LAPDQR---GIVTGGADKTV-KFWEFELIKDQS------SA-QKRL----------------------------AVKHVRTLQLED-DVLCVRFSPDH R_norvegicus_ENSRNOP00000012235 LLIHTFSSCHRDWITGCT----WTKDN----ILISCSSDGSV-GLWNPEAGQQLG---------------------------------------------QFPGH-QS-AVSAVVAVEEH S_cerevisiae_YCR057C --CLATFEEHTSSVTAVQ----FAKRGQ---VMFSSSLDGTV-RAWDLIRYRNFR---------------------------------------------TFTGT-ERIQFNCLAVDPSG G_gorilla_ENSGGOP00000009169 VICVAQGSGHTHSVGTVC----CSRLKES--FLVTGSQDCTV-KLWPLPKALLSKNTAP--DNGPILL----------------------------QAQTTQRCH-DK-DINSVAIAPND T_nigroviridis_ENSTNIP00000007980 --LLESVDAHAGAVWALC----LAPDQR---GLVTGSADKTV-KFWDFELVKDQD------AG-HKRL----------------------------TVKHTRTLQLEE-DVLCVKLSPDH H_sapiens_ENSP00000331815 VMCVAQGSGHTHSVGTVC----CSRLKES--FLVTGSQDCTV-KLWPLPKALLSKNTAP--DNGPILL----------------------------QAQTTQRCH-DK-DINSVAIAPND M_mulatta_ENSMMUP00000010429 VICVAQGSGHTHSVGTVC----CSRLKES--FLVTGSQDCTV-KLWPLPKALLSKNTAP--DNGPILL----------------------------QAQTTQRCH-DK-DINSVAIAPND X_tropicalis_ENSXETP00000035244 SVVHALPSCHRDWVTACS----WTDAD----MLVSCSGDGSV-CLWDIQREERLL---------------------------------------------DFAGH-QS-AVSSAICMGER P_troglodytes_ENSPTRP00000001997 --LLETIDAHDGALWSMS----LSPDQR---GFVTGGADKSV-KFWDFELVKDEN------ST-QKRL----------------------------SVKQTRTLQLDE-DVLCVSYSPNQ P_pygmaeus_ENSPPYP00000007898 VICVAQGSGHTHSVGTVC----CSRLKES--FLVTGSQDCTV-KLWPLPKALLSKNTAP--DNGPILL----------------------------QARTTQRCH-DK-DINSVAIAPND M_musculus_ENSMUSP00000046830 VACVAQGSGHTHSVGTIC----CSRLKES--FLVTGSQDCTV-KLWPLPEALLAKSTAA--DSGPVLL----------------------------QAQTTRRCH-DK-DINSLAVSPND R_norvegicus_ENSRNOP00000018405 VACVAQGSGHTHSVGTIC----CSRLKES--FLVTGSQDCTV-KLWPLPEALPSKNTAS--DGDLIPL----------------------------QAQSTQRCH-DK-DINSLAVSPND A_aegypti_AAEL004526-PA VQCVAIGLKHTNAVGSIA----ISKVSGK--FCASVSQDKCL-KVWKIPKEFNETTD----EKELTRL----------------------------NCTLTELAH-EK-DINCVCISPND P_pygmaeus_ENSPPYP00000001131 --LLETIDAHDGALWSMS----LSPDQR---GFVTGGADKSV-KFWDFELVKDEN------ST-QKRL----------------------------SVKQTRTLQLD--DVLCVSYSPNQ P_troglodytes_ENSPTRP00000053800 VMCVAQGSGHTHSVGTIC----CSRLKES--FLVTGSQDCTV-KLWPLPKALLSKNTAP--DNGPILL----------------------------QAQTTQRCH-DK-DINSVAIAPND M_mulatta_ENSMMUP00000011166 --LLETIDAHDGALWSMS----LSPDQR---GFVTGGADKSV-KFWDFELVKDEN------ST-QKRL----------------------------SVKQTRTLQLDE-DVLCVSYSPNQ R_norvegicus_ENSRNOP00000026726 --LLETIAAHDGALWSMS----LSPDQR---GFVTGGADKAV-KFWDFELVTDKN------ST-QKRL----------------------------SVKQTRILQLDE-DVLYVCYSPDQ O_anatinus_ENSOANP00000015573 VSCVGVGTGHTHSVGTVS----CSRMQEN--FVVTGSQDCTV-KLWPL-AKISGS------GPGLLPL----------------------------QAQATQRVH-DK-DINSVAVSPNN T_guttata_ENSTGUP00000013749 --XXETLDAHDGAVWSIA----LSPDQH---GFVTGGADKCV-KFWEFELVKDES------SV-QKRL----------------------------SMKHVRVLQLDE-DVLCVRYSPNQ C_familiaris_ENSCAFP00000028736 VACVAQGSGHTHSVGTIC----CSRLKET--FLVTGSQDCTV-KLWPIPEALLSKGTAP--DSGPILL----------------------------QAQATQRCH-DK-DINSVAVAPND X_tropicalis_ENSXETP00000015707 VTCVAQGSGHTNGVGTIS----CSRMKEA--FLVSGSQDYTI-KLWKLPESLANKQSKGN-SGDLETL----------------------------LACATEKAH-DKRDTIKLWQHRDS E_caballus_ENSECAP00000009299 VLICSFSACHRDWVTGCA----WTKDN----LLVSCSSDGSV-GLWDPESGQQLG---------------------------------------------QFLGH-QS-AVSAVVAVEEH M_domestica_ENSMODP00000006461 --LLETVEAHDGALWSIS----LSPDQH---GFVTGGADQSV-KFWDFELVKDEN------CA-QKRL----------------------------SVKQTRILQLDE-EVLSVRYSPNQ M_musculus_ENSMUSP00000006444 LLIHTFSSCHRDWITGCA----WTKDN----ILVSCSSDGSV-GLWNPEAGQQLG---------------------------------------------QFSGH-QS-AVSAVVAVEEH H_sapiens_ENSP00000308179 --LLETIDAHDGALWSMS----LSPDQR---GFVTGGADKSV-KFWDFELVKDEN------ST-QKRL----------------------------SVKQTRTLQLDE-DVLCVSYSPNQ T_rubripes_ENSTRUP00000006345 --LLETVDAHDGALWSLC----LAPDQR---GLVTGSADKTV-KFWEFELIKDGE------MS-HKRL----------------------------TVKHKRTLQLEE-DVLCVKFSPDH E_caballus_ENSECAP00000017445 VACVAQGSGHTHGVGTIC----CSRLKET--FLVTGSQDCTV-KLWPLPEALLSKSTVP--DGGPVLL----------------------------QAQATQRCH-EK-DINSVAVAPND 2530 2540 2550 2560 2570 2580 2590 2600 2610 2620 2630 2640 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 -----TKFSSTSADK----TAKIWSFD---LLSPLH-ELKGHNGCVRCSAFSLD---------GILLATGDDN-GEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCF-SPDSKTL E_caballus_ENSECAP00000022364 -----TKFSSTSADK----TAKIWSFE---LLSPLH-ELRGHKGCVRCSVFSGD---------STLLATGDDN-GEIRIWSVSNGELLHLCAPISVEEGAATHGGWVTDLCF-SPDSKML B_taurus_ENSBTAP00000028867 -----TKFSSTSADK----TAKIWSFE---LLSPLH-ELRGHKGCVRCSSFSVN---------NTLLATGDDN-GEIRIWNVSNGELLHLCAPISVEEGAATHGGWVTDLCF-SPDTKML P_troglodytes_ENSPTRP00000042795 -----TKFSSTSADK----TAKIWSFD---LLLPLH-ELRGHNGCVRCSAFSVD---------STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCF-SPDGKML P_pygmaeus_ENSPPYP00000005543 -----TKFSSTSADK----TAKIWSFD---HLLPLH-ELRGHNGCVRCSAFSVD---------STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCF-SPDGKML H_sapiens_ENSP00000353059 -----TKFSSTSADK----TAKIWSFD---LLLPLH-ELRGHNGCVRCSAFSVD---------STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCF-SPDGKML R_norvegicus_ENSRNOP00000010869 -----TKFSSTSADK----TAKIWSFE---LPSPLH-ELKGHNSCVRCSAFSLD---------GILLATGDDN-GEIRIWNVSDGQLLHLCAPISIEEGTATHGGWVTDVCF-SPDRKML M_mulatta_ENSMMUP00000038848 -----TKFSSTSADK----TAKIWSFD---LLLPLH-ELRGHNGCVRCSAFSVD---------STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCF-SPDGKML C_familiaris_ENSCAFP00000009806 -----TKFSSTSADK----TAKIWSFE---LLSPLH-ELRGHKGCVRCSVFSVD---------STLLATGDDN-GEIRIWNVSNGELLHLCAPILVEEGAATHGGWVTDLCF-SPDSKML O_anatinus_ENSOANP00000008896 -----TKFSSTSADK----TAKIWSFE---NSSLLH-ELSGHEGCVRCSAFSDD---------SSLLATGDDN-GEIRIWDVSKGEILHLCAPGPVGE-ASTHGGWVTDLCF-SPDSKIL M_domestica_ENSMODP00000009538 -----TKFSSTSADK----TAKIWNFE---SSFPLH-ELRGHEGCVRCSVFSGD---------NALLATGDDN-GEIRIWSVSSGGLLHSCLPLTVEEGEATYGGWVTDLHF-SPDGRML T_guttata_ENSTGUP00000009081 -----SKFSSASADK----TAKIWSFE---SSSVLH-ELKDHEACVRCCTFSPN---------NKLLATGDDK-GEIRIWDVLTGTLLHFCSPVTVDEGEPTHGGWVTDLSF-SPDSKML G_gallus_ENSGALP00000037436 -----SRFSSTSADK----TAKIWSFE---SSSVLH-ELKGHEACVRCSAFSPS---------NKLLATGDDK-GDIRIWDILTGELLHFCSSVTVDEEEPTHGGWVTDLSF-SPDSKML A_carolinensis_ENSACAP00000012965 -----TMFSTTSSDK----TAKIWSFE---TSSMLH-KLNSHESCVRCCAFSLN---------NELLATGDDN-REIRVWDVSRGELLHLCSRASIDEGESAHEGWVTDLCF-SPDNKIL X_tropicalis_ENSXETP00000014654 -----TKFSSASTDK----SAKIWNLD---NCALLH-ELNKHQSCVRCCRFSWD---------NQYLATGDDS-GKIMIWSVQNGELLRECCDVSVNNENSLHDGWVTDLHF-SPDNKLI G_gorilla_ENSGGOP00000008216 -----TKFSSTSADK----TAKIWSFD---LLLPLH-ELRGHNGCVRCSAFSVD---------STLLATGDDN-GEIRIWNXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXX-XXXXXXX D_rerio_ENSDARP00000008347 -----RLFATTSANR----TAKVWSSA---SWKMIF-LLEGHKDCVRSCRFSWD---------NKRLATGDDN-GEIRLWSMLDGALLKICSRDTKDSMDSYHGGWVTDLHF-SPDNRVL O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 -----CLFATTSADR----TAKLWHCE---SWQCVH-ALKGHQECVRSCRFSWD---------SRRVATGDDN-GEIRLWSVSDGSLLKICSRDSKDGMDSLHGGWVTDLHF-SRDDSLL T_nigroviridis_ENSTNIP00000013938 -----CFFATTSADR----TAKLWHCE---SWQCVH-TLKGHQECVRSCRFSWD---------SRRVATGDDN-GEIRLWSAKDGSLLKICSREGKDGMDSLHGGWVTDLHF-SRDNTLL G_aculeatus_ENSGACP00000026214 GGGKERMERNRKTNE----GPKLWHCE---TWKCVH-TLSGHRDCVRSCRFSWD---------GRRLATGDDN-GEIRLWSVMEGTLLRICSRDGKDCMDSLHGGWVTDLHF-SPDNGLL O_latipes_ENSORLP00000019346 -----RLFATSSADR----TAKLWHCE---AWQCTF-TLTGHQECVRSCRFSWD---------SECLATGDDN-GEIRLWNVNDGSLLRICSREVKDSMDSFHGGWVTDLHF-SPDNSLL C_elegans_Y45F10B.10 ----GNFIATGSRDM----SLKIWQID---KGFLTQ-VLVGHENVVTCCCISFD---------ERLVVSGARD-EKIIVWNVQSGDMVCTV----------NTTAAITSLSM-TGDSTVV C_intestinalis_ENSCINP00000010464 -----RFIAASLLDC----SVKIFYVD---SLKFFL-SLYGHSLPPSCVSISSD---------STLIVSGSPD-RNVKIWGLDFGDCHRSL---------FAHDNDVTGLKF-VPDTHLF M_domestica_ENSMODP00000008927 -------VVSVDRDG----VLKVWNLR---GVELT--SIPAHSGPISHCVAIQEPRTAGQPGSELLVITVGLD-GATRLWHPLLVFQTHTL---------LGHSGPIISAAA-SETLGLL M_domestica_ENSMODP00000027702 -----KLLASGSQDR----TAKLWSLP---DFSLLG-VFSGHRRGVWCVQFSPM---------DQVLATASAD-GSLKLWGLQDFSCLKTF---------EGHDASVLRVTF-VSRGTQL T_nigroviridis_ENSTNIP00000004057 -----KLLASASQDR----TAKLWSLAGEGSLGLLG-VCRGHRRGVWAVCFSPV---------DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVIF-VSRGTQL T_guttata_ENSTGUP00000006840 -----KLLATGSQDR----LAKLWSCS---DCSLLG-VFSGHKRGIWCVQFSPV---------DQVLATSSAD-GTLKLWGLRDFSCLKTF---------EGHDASVLKIIF-VSRGAQL B_taurus_ENSBTAP00000001564 -------VVSVGRDG----TLKVWDHQ---GVEMT--SIPAHSGPISHCVAALEPRAAGQPGSELLVVTVGLD-GATRLWHPLLVFQTHTL---------LGHSGPVSAAAV-SETSGLL H_sapiens_ENSP00000262715 -------VVSVSRDG----TLKVWDHQ---GVELT--SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD-GATRLWHPLLVCQTHTL---------LGHSGPVRAAAV-SETSGLM C_intestinalis_ENSCINP00000019387 -----KLIASGSQDK----LAKLWKVS---DGSVVG-TFKGHKRGIWCVQFSPM---------DQVLATSSAD-GSIKLWSLSDFTCLKTL---------EGHDCSVLKVIF-IAKGTQM G_gallus_ENSGALP00000008904 -----KLIATGSQDR----LAKLWSCP---DCSLLG-VFTGHKRGIWCVQFSPV---------DQILATSSAD-GTLKLWGLQDFSCLKTF---------EGHDASVLKIIF-VSRGTQL P_troglodytes_ENSPTRP00000010340 -------VVSVSRDG----TLKVWDHQ---GVELT--SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTIGLD-GATRLWHPLLVCQTHTL---------LGHSGPVRAAAV-SETSGLM S_cerevisiae_YLR222C -----SIFATASYDK----TCKIWNLE---NGELEA-TLANHKRGLWDVSFCQY---------DKLLATSSGD-KTVKIWSLDTFSVMKTL---------EGHTNAVQRCSF-INKQKQL G_aculeatus_ENSGACP00000015863 -----KLLASGSQDR----TAKLWSLEAAGRVGMLG-VFRGHRRGVWAVCFSPI---------DQVLATSSAD-GAAKLWGLQDFSCLKTF---------EGHDASVLKVIF-VSRGTQL B_taurus_ENSBTAP00000027147 -----KLLATGSQDR----TAKLWALP---RCQLLG-TFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL A_gambiae_AGAP009615-PA -----RLIATASQDK----TAKLWDAS---DLSVVG-VFRGHTRGIWAVRFSPV---------DQILLTNAAD-CTIKLWSLEDMTCLKTL---------EGHDSSVLRVEF-LTNGMQL D_rerio_ENSDARP00000023281 -----RLLAVSLLDC----TVKIFYTD---TLKFFL-SLYGHKLPVLCLDISHD---------SALIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQF-VPKTHLF T_rubripes_ENSTRUP00000017221 -----KLLASASQDR----TAKLWSLAGEGNLGLLG-VFRGHRRGVWTVCFSPV---------DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVIF-VSRGTQL A_gambiae_AGAP004827-PA -----KFAVCTNGDS----SLRIWSLT---REDEK--YTVSHSDEITCFIITAD---------SLYVITGSRD-MSLKVWQATGGKLAQVL---------VGHTDAVTCVAVSVTNKSQV A_aegypti_AAEL001276-PA -----KFAVCTNGDT----SLRIWSLT---REDEK--FLVSHSGEITCFIITAD---------SLYLISGSKD-MSLKVWQASGGKLAQVL---------VGHTDAVTCVAVSVTNKSQV M_mulatta_ENSMMUP00000021364 -------VVSVGRDG----TLKVWDHQ---GVELT--SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTIGLD-GATRLWHPLLVSQTHTF---------LGHSGPVRAAAV-SETSGLL P_pygmaeus_ENSPPYP00000006332 -------VVSVGRDG----TLKVWDHQ---GVELT--SIPAHSGPISHCAAAMETRAAGQPGSELLVVTIGLD-GATRLWHPLLVCHTHTF---------LAHSGPVHAAAV-SETSGLM O_anatinus_ENSOANP00000004860 -----KLLAVSLLDC----TVKLFYVD---TLKFFL-SLYGHKLPVLCMDISSD---------GQLLATGSAD-RNVKIWGLDFGDCHRSL---------FAHADSVMFLQF-VPKTHLF D_melanogaster_FBpp0085899 -----RFAVSTNGDN----TLKIWSLT---QEDEK--YSVSHSDEITCFEISAD---------SVHIISGSRD-MSLKVWQATGGKLSQVL---------VGHSDAVTCVAVSVTNKTQV O_latipes_ENSORLP00000010395 -----RLLAASLLDC----TVKIFHSD---TLKFFL-SLYGHKLPVLCLDISHD---------STLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMFLQF-VPKTHLF R_norvegicus_ENSRNOP00000012235 -------IVSVSRDG----TLKVWDRQ---GVELT--SIPAHSGPISQCAAALEPRPAGQPGSELLVVTVGLD-GATKLWHPLLVCQIHTL---------QGHSGPVTAAAA-SEASGLL S_cerevisiae_YCR057C -----EVVCAGSLDN---FDIHVWSVQ---TGQLLD-ALSGHEGPVSCLSFSQE---------NSVLASASWD-KTIRIWSIFGRSQQVEP---------IEVYSDVLALSM-RPDGKEV G_gorilla_ENSGGOP00000009169 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL T_nigroviridis_ENSTNIP00000007980 -----RLLAVSLLDC----TVKLFYAD---TLKFFL-SLYGHKLPVLCLDICHD---------STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQF-VPKTHLF H_sapiens_ENSP00000331815 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL M_mulatta_ENSMMUP00000010429 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL X_tropicalis_ENSXETP00000035244 -------VITTSRDG----CLKVWNLA---GLEVA--NISAHQEQINQSAAFWMP-VDRQDDANLVVYVACSD-GSVLKWSPLQMDQIQTL---------YGHGGPVISSSSSSSNCKVI P_troglodytes_ENSPTRP00000001997 -----KLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVICMDISHD---------GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMDLQF-VPKSHLF P_pygmaeus_ENSPPYP00000007898 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL M_musculus_ENSMUSP00000046830 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFTGHRRGLWNVQFSPT---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGSQL R_norvegicus_ENSRNOP00000018405 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWNVQFSPT---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGAQL A_aegypti_AAEL004526-PA -----RLIATGSQDK----TAKLWDAS---NLSLVG-VFRGHRRGIWAVRFSPV---------DQILLTNAAD-CSIKLWSLTDMTCLKSL---------EGHESSVLRVEF-LSHGMQL P_pygmaeus_ENSPPYP00000001131 -----KLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVICMDISYD---------GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQF-VPKSHLF P_troglodytes_ENSPTRP00000053800 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL M_mulatta_ENSMMUP00000011166 -----KLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVICMDISYD---------GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQF-VPKSHLF R_norvegicus_ENSRNOP00000026726 -----RLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVICMDISHD---------GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMHLRF-VPKSHLF O_anatinus_ENSOANP00000015573 -----KLLATGSQDH----LAKLWTLP---DLTLLG-VLSGHRRGIWCVQFSPM---------DQVLATASAD-SCIKLWALQDLACLKTF---------EGHDASVLKVTF-VSRGTQL T_guttata_ENSTGUP00000013749 -----KLLAVSLLDC----TVKVFYVD---TLKFFL-SLYGHKLPVLCMDICYD---------GTLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLQF-VPKSHLF C_familiaris_ENSCAFP00000028736 -----KLLATGSQDR----TAKLWALP---HCQLLG-IFSGHRRGLWCVQFSPM---------DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVVF-VSRGTQL X_tropicalis_ENSXETP00000015707 -----PVLSTIQQEQPPKDTIKLWQHR---DSPVLSTILQEQPPKFAHSLYREI---------PQNYSSIEIPLDTIKIWHHRDSPVLSTI---------QQEQPP----NF-APVPSLL E_caballus_ENSECAP00000009299 -------VVSVGRDG----TLKVWDHQ---GVELT--SIPAHSGPISQCAAALEPRAAGQPGSELLVVTAGLD-GTTQLWHPLLVFQTHTL---------LGHSGPVSAAAV-SETSGLL M_domestica_ENSMODP00000006461 -----KLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVLCMDISSD---------GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHEDSVMYLQF-VPKSHLF M_musculus_ENSMUSP00000006444 -------IVSVSRDG----TLKVWDHQ---GVELT--SIPAHSGPISQCAAALEPRPGGQPGSELLVVTVGLD-GATKLWHPLLVCQIRTL---------QGHSGPVTAAAA-SEASGLL H_sapiens_ENSP00000308179 -----KLLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHKLPVICMDISHD---------GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQF-VPKSHLF T_rubripes_ENSTRUP00000006345 -----RLLAVSLLDC----TVKLFYTD---TLKFFL-SLYGHKLPVLCLDICHD---------STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQF-LPKTHLF E_caballus_ENSECAP00000017445 -----KLLATGSQDR----TAKLWALP---QCQLLG-VFLGHRRGLWCVQFSPM---------DQVLATASAD-GTVKLWALQDFSCLKTF---------EGHDASVLKVAF-VSRGTQL 2650 2660 2670 2680 2690 2700 2710 2720 2730 2740 2750 2760 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 V--S--AG--GYLK--WWNVATGDSSQTFYTNGTNLKK--------------------IHVSPDFRTYVTVDNLGILYILQVLE------------------------------------ E_caballus_ENSECAP00000022364 V--S--AE--GSLK--WWNAVTGESAQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQVLE------------------------------------ B_taurus_ENSBTAP00000028867 V--S--AG--GYLK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILKILE------------------------------------ P_troglodytes_ENSPTRP00000042795 I--S--AG--GYIK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQTLE------------------------------------ P_pygmaeus_ENSPPYP00000005543 I--S--AG--GYIK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQTLE------------------------------------ H_sapiens_ENSP00000353059 I--S--AG--GYIK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQTLE------------------------------------ R_norvegicus_ENSRNOP00000010869 V--S--AG--GYLK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFRTYVTVDNLGILYILQVLE------------------------------------ M_mulatta_ENSMMUP00000038848 I--S--AG--GYIK--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQTLE------------------------------------ C_familiaris_ENSCAFP00000009806 V--S--AG--GYLK--WWNVVTGESSQTFYTNGTCLKK--------------------IHVSSDFKTYVTVDNLGILYILQMLE------------------------------------ O_anatinus_ENSOANP00000008896 V--S--AG--GFLK--WWNMDTGESLQTFYTNGTNLKT--------------------IFVSPSFKSYVTVDNLGILYVLQMLE------------------------------------ M_domestica_ENSMODP00000009538 V--S--AG--GYLK--WWDVDTGESLQTFYTNGTNLKT--------------------IHVSPSFRAYVTVDNLGILYILQALE------------------------------------ T_guttata_ENSTGUP00000009081 V--S--SG--GYLK--WWNVTTGESLQTFYTNGTNLKS--------------------IHVSPNFKVYVTVDNLGILYVLQ--------------------------------------- G_gallus_ENSGALP00000037436 V--S--SG--GYLK--WWDVTTGESLQTFYTNGTNLKS--------------------IHVSPNFDVYVTVDNLGILYVLRKL------------------------------------- A_carolinensis_ENSACAP00000012965 V--S--SA--GYIK--WWNVDTGQPLQTFYTNGTDLKS--------------------LHVSPDFKVCVTVDNLGILYVLRIME------------------------------------ X_tropicalis_ENSXETP00000014654 V--S--SG--ANIK--WWEVDTGACKQTFYTIGTNLKS--------------------IHVCSIFRTFVTIDNLGILYVLQLIE------------------------------------ G_gorilla_ENSGGOP00000008216 X--X--XX--XXXX--WWNVVTGESSQTFYTNGTNLKK--------------------IHVSPDFKTYVTVDNLGILYILQTLE------------------------------------ D_rerio_ENSDARP00000008347 V--S--TG--GYIK--WWSVESGEALQTFYTMGGNLKK--------------------IHVSPDFSTFITVDSIGILYILKRLEGEGT-------------------------------- O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 V--S--TG--GYIK--WWDVAQGEALQTFHPTGSALKR--------------------IHVSADFSTFVTIDNIGILYVLQRVIASGC-------------------------------- T_nigroviridis_ENSTNIP00000013938 V--S--TG--GYIKKYWGSIPSLQSAHFF------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000026214 V--S--TG--GYIK--WWDVETGEALQTFFTTGTALKR--------------------IHVSSDFSTFVTIDSIGILYVLQRVVIDRGYGA----------------------------- O_latipes_ENSORLP00000019346 V--S--AG--GYIK---------------------------------------------------------------------------------------------------------- C_elegans_Y45F10B.10 F--S--TTEDGWVE--TWSTTKGRLLSTFNAHRPIKKL--------------------INSYESHRMLLLLENCAQLPILCLHNTPAVGVEATR-------------------------- C_intestinalis_ENSCINP00000010464 F--S--CGKDGLVK--QWDADNFTLIQVLQGHLGPVWS--------------------LCVSPDGDHVATCGNDRSLRLWNRSMEVVIPDEERE-------------------------- M_domestica_ENSMODP00000008927 L--T--ASKDGSVR--LWHVPKE-DDTGAGERPTAITA--------------------VAWAPDGSLAVSGSQAGELILWQDAKAVARAQVPGR------------------------VS M_domestica_ENSMODP00000027702 L--S--SGSDGLLK--LWTIKTNECVRTLDGHEDKVWG--------------------LHCNRQDEAVVTGASDARILLWKDVTETEQAEEQAR-------------------------- T_nigroviridis_ENSTNIP00000004057 L--T--SGSDGLVK--LWTIKTNECVKTLDAHQDKVWG--------------------LHGSRRDDKMVTGSADSNITVWEDVTEIEMAEEQAK-------------------------- T_guttata_ENSTGUP00000006840 L--S--SGSDGLLK--LWTIKTNECVKTLDGHEDKIWG--------------------LHSNKKDDMVVTASSDSCITLWQDVTEIEEKEAQAK-------------------------- B_taurus_ENSBTAP00000001564 L--T--TSEDGSLR--LWQVPKEADDTYRPRSPAAITA--------------------VAWAPDGSAAVSGNQAGELTLWQEAKAVVTVQAPGC------------------------IS H_sapiens_ENSP00000262715 L--T--ASEDGSVR--LWQVPKEADDTCIPRSSAAVTA--------------------VAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH------------------------IG C_intestinalis_ENSCINP00000019387 V--S--CGSDGLLK--LWTIKLSECIQTVEAHDEKAWA--------------------LCSDVEDTMIISGGADSIISFWKDVTDEQRREDIEA-------------------------- G_gallus_ENSGALP00000008904 L--S--GGSDGLLK--LWTIKTNECVKTLDGHEDKIWG--------------------LHTNKQDDMVVTASSDSSITLWKDVTEIEQEEAQAK-------------------------- P_troglodytes_ENSPTRP00000010340 L--T--ASEDGSVR--LWQVPKEADDTCIPRSSAAVTA--------------------VAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH------------------------IG S_cerevisiae_YLR222C I--S--CGADGLIK--IWDCSSGECLKTLDGHNNRLWA--------------------LSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEK-------------------------- G_aculeatus_ENSGACP00000015863 L--T--SGSDGLVK--LWTIKTNECVKTLDAHQDKVWG--------------------LHGSRKDDKMVTGSADSNITLWMDVTEVELAEEQAK-------------------------- B_taurus_ENSBTAP00000027147 L--S--SGSDGLLK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDRALTGASDSRVVLWKDVTEAEQAEEQAK-------------------------- A_gambiae_AGAP009615-PA L--S--AGADGLVK--LWSIKTSDCVQTLDKHDNRVWA--------------------LCVTRDESMFYSGGSDSQLIQWQDVTESKRQQELDQ-------------------------- D_rerio_ENSDARP00000023281 F--T--AGKDKKIK--QWDADKFEHIQTLEGHHREVWC--------------------LAISPNGDHIVSSSHDKSLRLWERTREPIILEEEKE-------------------------- T_rubripes_ENSTRUP00000017221 L--T--SGSDGLVK--LWTIKTNECVKTLDAHQDKVWG--------------------LHGNRRDNRMVTGSADSNITVWEDVTEMEVAEEQAK-------------------------- A_gambiae_AGAP004827-PA I--S--GSKDSNLI--IWDIHTGEEIHTLAGHLGPVTC--------------------VKVSADGTTAVSGSDDKTLIVWETKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDNSCLP A_aegypti_AAEL001276-PA I--S--GSKDSNLI--IWDIHTGEEIHTLAGHLGPVTC--------------------VKVSADGTTAVSGSDDKTLIVWEIKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDSSCLP M_mulatta_ENSMMUP00000021364 L--T--ASEDGSVR--LWQVPKEADDTCIPRSSAAITA--------------------MAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH------------------------IG P_pygmaeus_ENSPPYP00000006332 L--T--ASEDGSVR--LWQVPKEADDTCIPRSSAAVTA--------------------VAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGH------------------------IG O_anatinus_ENSOANP00000004860 F--T--AGKDNKIK--QWDADKFEHVQTLEGHHHEVWC--------------------LAVSPSGDHLVSASHDKSLRLWERTREPLVLEEERE-------------------------- D_melanogaster_FBpp0085899 L--S--GSKDMNLI--LWDLLTGEEVHTLAGHLGPVIG--------------------VKVSADGSTAVSGSDDKTLIVWETKRGLALTSLQMHVPFTHFDISLEVSRVLVQLVDSYNLP O_latipes_ENSORLP00000010395 F--T--AGKDRKIK--QWDADKFELVQTLEGHHREVWC--------------------LAISPNGDHLVSASHDKSLRLWERTREPIILEEERE-------------------------- R_norvegicus_ENSRNOP00000012235 L--T---SDNSSVR--LWQIPKEADDTCKPRSSAVITA--------------------VAWAPDGSLVVSGNEAGELTLWQKAQAVATARAPGR------------------------VS S_cerevisiae_YCR057C A--V--STLKGQIS--IFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMA---------------LNGTLEF G_gorilla_ENSGGOP00000009169 L--S--SGSDGLVK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDRTLTGASDSRVILWKDVTEAEQAEEQAR-------------------------- T_nigroviridis_ENSTNIP00000007980 F--T--AGKDKKIK--QWDADKFEHVQTLEGHHREVWC--------------------LAISPNGDHLVTASHDKSLRLWERTREPVILEEERE-------------------------- H_sapiens_ENSP00000331815 L--S--SGSDGLVK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQAR-------------------------- M_mulatta_ENSMMUP00000010429 L--S--SGSDGLVK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDRALTGASDSRVILWK---VAEQAEEQAR-------------------------- X_tropicalis_ENSXETP00000035244 A--T--ASLDGSVR--LWEEPSRDGHVMETRHVGRVSA--------------------IAYSPDSELVASGGENGDVILWSQQRVLLSLQVNKM-----------------------CIS P_troglodytes_ENSPTRP00000001997 F--T--AGKDHKIK--QWDADKFEHIQTLEGHHQEIWC--------------------LAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE-------------------------- P_pygmaeus_ENSPPYP00000007898 L--S--SGSDGLVK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQAR-------------------------- M_musculus_ENSMUSP00000046830 L--S--SGSDGLLK--LWTIKSNECVRTLDAHEDKVWG--------------------LHCSQLDDHAITGGSDSRIILWKDVTEAEQAEEQAK-------------------------- R_norvegicus_ENSRNOP00000018405 L--S--SGSDGLLK--LWTIKSNECVRTLDAHEDKVWG--------------------LHCSRLDDHAITGGSDSRIILWKDVTEAEQAEEQAK-------------------------- A_aegypti_AAEL004526-PA L--S--AGADGLLK--LWSIKTSECLQTLDKHESRIWA--------------------LCVTEDESVFYSGGSDSQLIKWKDVTDEKREREMNE-------------------------- P_pygmaeus_ENSPPYP00000001131 F--T--AGKDHKIK--QWDADKFEHIQTLEGHHQEVWC--------------------LAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE-------------------------- P_troglodytes_ENSPTRP00000053800 L--S--SGSDGLVK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDRALTGASDSRVILWKDVTEAEQAEEQAR-------------------------- M_mulatta_ENSMMUP00000011166 F--T--AGKDHKIK--QWDADKFEHIQTLEGHHQEIWC--------------------LAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE-------------------------- R_norvegicus_ENSRNOP00000026726 F--T--AGKDHKIK--QWDADKFEHIQTLEGHHQEIWC--------------------LAVSPSGDYVVSASHDKSLRLWERTREPLILEEERE-------------------------- O_anatinus_ENSOANP00000015573 L--S--SGSDGLLK--LWTIKTNECVQTLDAHEDKVWG--------------------LHCNRQDNQALSGAGDACVVLWEDVTETELAEKQAK-------------------------- T_guttata_ENSTGUP00000013749 F--T--AGKDSKIK--QWDADKFEHIQTLEGHHQEVWC--------------------LALSPNGDYVVSASHDKSLRLWERTREPLILEEERE-------------------------- C_familiaris_ENSCAFP00000028736 L--SRPSGSDGLVK--LWTIKNNECVKTLDAHEDKVWG--------------------LHCSRLDDRALTGASDSCVILWKDVTEEEQSEEQAR-------------------------- X_tropicalis_ENSXETP00000015707 LYPSPLSGSDGLLK--LWTIKTNECVKTLDTHEDKVWG--------------------LHCNREDDALVTGSADSAIILWKDVTETELAEEQAK-------------------------- E_caballus_ENSECAP00000009299 L--T--TSEDGSVR--LWQVPKEADDTYIPRSPTAITA--------------------VAWAPDGSLAVSGNQAGELTLWQEAKAVATAQAPGR------------------------IS M_domestica_ENSMODP00000006461 F--T--AGKDHKIK--QWDADRFEHIQTLEGHHQEVWC--------------------LAVSPNGDYIVSSSHDKSLRLWERTKEPLILEEEQE-------------------------- M_musculus_ENSMUSP00000006444 L--T---SDDSSVQ--LWQIPKEADDSYKPRSSVAITA--------------------VAWAPDGSMVVSGNEAGELTLWQQAKAVATAQAPGR------------------------VS H_sapiens_ENSP00000308179 F--T--AGKDHKIK--QWDADKFEHIQTLEGHHQEIWC--------------------LAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE-------------------------- T_rubripes_ENSTRUP00000006345 F--T--AGKDKKIK--QWDADKFEHIQTLEGHHREVWC--------------------LAVSPSGDHLVSASHDKSLRLWERTREPVILEEERE-------------------------- E_caballus_ENSECAP00000017445 L--S--SGSDGLLK--LWTIKNNECVRTLDAHEDKVWG--------------------LHCSRLDDHALTGASDSCVILWKDVTEVEQAEEQAK-------------------------- 2770 2780 2790 2800 2810 2820 2830 2840 2850 2860 2870 2880 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ---------------RRSARAQSVSSASNEPVASTSAGEIKKDPILSSNNGGNA--------QSAPRATAPKPTFDM------------------------------------------- C_intestinalis_ENSCINP00000010464 -------------HEREKEEEKLLAKNQDTTVSGKSRSCTFYNFLRKKRTTVESV-------RGAEKIMEAIELFNEEKVKEEEF-----KFINK--NKDVFYKSDHPILRAYGNITVS- M_domestica_ENSMODP00000008927 ALCWISPQTFFALISDKNLIKWQVK-KEGLLLDIFSLGHDLQLNQQDSHNLLSGM-------DLAPDRCSLILAKPLLGML-LKVDSTPSEFWHKLSLHSLTLFSTHEEHGVFSLDTLR- M_domestica_ENSMODP00000027702 -------------QEEQILKQQELSN------------------LLQEKQYLRAL-------GLAISLDRPHTVLTVIKAILKEV----------------------------------- T_nigroviridis_ENSTNIP00000004057 -------------QEEHILKQQELSN------------------LLQEKKYLKAL-------GLAISLDQPHTVLTVIKAIRQTE----------------------------------- T_guttata_ENSTGUP00000006840 -------------QEEQIMKEQELSN------------------LLHEKRYLKAL-------CLAISLDRPHTVLTVVKAILREP----------------------------------- B_taurus_ENSBTAP00000001564 ALLWYSAHTLIVVSANEKVSEWQVELQKGSTPRNVSLR--LNRVLQEDLGFLTSV-------GLAPDAHSLILAKADLQLLHMKPGDEPSVIWQSYSEDPMML-STHQDYGVFVLQSMKL H_sapiens_ENSP00000262715 ALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLH--LNRILQEDLGVLTSL-------DWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STHKEYGIFVLQPKDP C_intestinalis_ENSCINP00000019387 -------------KQKTMLHHQELQN------------------LLQEKKYEKAL-------HFAIKLSQPFTALNVIKELMWET----------------------------------- G_gallus_ENSGALP00000008904 -------------REEQIMKEQELSN------------------LLHEKRYLKAL-------GLAISLDRPHTVLTVIKAILKES----------------------------------- P_troglodytes_ENSPTRP00000010340 ALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLH--LNRILQEDLGVLTSL-------DWAPDGHFLILAKADLKLLCMKPGDAPSEIWSNYTENPMIL-STHKEYGIFVLQPKDP S_cerevisiae_YLR222C -------------AKLQVEQEQSLQN------------------YMSKGDWTNAF-------LLAMTLDHPMRLFNVLKRALGES------------------------------RSRQD G_aculeatus_ENSGACP00000015863 -------------QEDQILKQQELSN------------------LLHEKKYLKAL-------GLAISLDQPRTVLTVIKAIRQVQ----------------------------------- B_taurus_ENSBTAP00000027147 -------------REEQVVKQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- A_gambiae_AGAP009615-PA -------------RKDTLLQEQELSN------------------LLSERKLLKAL-------RLSLNLDRPLSTLKIVNEVIRTK----------------------------------- D_rerio_ENSDARP00000023281 -------------MEREAEFEESLAKGDDPVVPGETKG----EAEPAGRKTVETV-------KAAERIMEAIELYREESKNLEEH-----KAACEAAGKKLPPLKMNPILMAFGNISPSR T_rubripes_ENSTRUP00000017221 -------------QEEQILKQQELSN------------------LLQEKKYLKAL-------GLAISLDQPHTVLTVIKAIRQTE----------------------------------- A_gambiae_AGAP004827-PA IICLHNSPASYIKLPTYSAPARDVEDLRPAGPKRPARRLLKKEVSLDTYTWQKKYAHLTSSVMMAQVDERLKRRFSVSASMEEIS-----KLAEAKNVESQATLGPEQAALAQSQHFDQL A_aegypti_AAEL001276-PA IICLHNSPASYIKLPTYSAPARDVEDLRPAGPKRPARRLLKKEVSLDTYTWQKKYAHLTSSVMMAQVDERLKRRFSVSASMEEIS-----KLAESKTMESQQNLGPEQAALAQSQHFDQL M_mulatta_ENSMMUP00000021364 ALIWSSARTFFVLSADEKISEWQVKLRKGSAPGNFSLH--LNRILQEDLGVLTSL-------GWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STHKEYGVFVLQPKDP P_pygmaeus_ENSPPYP00000006332 ALIWSSARTFFVLSADEKISEWQVKLQKGSAPGNLSLH--LNRILQEDLGVLTSL-------GWAPDRHFLILAKADLRLLCMKPGDAPSEIWNSYTENPMIL-STHKEYGIFVLQPKDP O_anatinus_ENSOANP00000004860 -------------MQREAEYEDSVAKEDQPVVPGEAQG----EASLAGKKTIQTV-------KAAECIMEAVELFREETAKRAEH-----AAVCKAAGKEVPLPP-NPLLQALGNISPSD D_melanogaster_FBpp0085899 VICLHNTPAQYVKLPTYSGPSKDVEDLRPQGPKRQMKRLLKKEVSLDTYTWQKKYGHLTSSVMMAQVDERLKRRFSVSASMEEIS-----KIAETKTGASQANLGPEQAALAQSQHFDQL O_latipes_ENSORLP00000010395 -------------MEREAEFEESVAKGDAPVVPGEVEG----EAAPAAKKTVETV-------KAAERIMEALELHREELRKMEEH-----KYACEGAGKQLPPPKPNPVLVAFGNVSPAR R_norvegicus_ENSRNOP00000012235 DLIWCSANAFFVLSANENVSEWQVELRKGSTCTNFRLY--LKRVLQEDLGVLTGM-------ALAPDGQSLILMKEDVELLQMKPGSTPSSICRRYAVHSSIL-CTSKDYGLFYLQQGNS S_cerevisiae_YCR057C LNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLLIYSTNDTILFDPFDLDVDVTPHSTVEALREKQFLNALVMAFRLNEEY G_gorilla_ENSGGOP00000009169 -------------QEEQVVRQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- T_nigroviridis_ENSTNIP00000007980 -------------MEREAEFEESMAKGDVPVVPGETPG----EAAPAGKKTVETV-------KAAERIMEALELFREERRKLEDH-----EYACRAAGRQLPAPKPNPILVAYGNVTPSR H_sapiens_ENSP00000331815 -------------QEEQVVRQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- M_mulatta_ENSMMUP00000010429 -------------QEEQVVRQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- X_tropicalis_ENSXETP00000035244 HLLFTSQRTFCVISNDLKVSRW-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000001997 -------------MEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETV-------KAAERIMEAIELYREETAKMKEH-----KAICKAAGKEVPLPS-NPILMAYGSISPSA P_pygmaeus_ENSPPYP00000007898 -------------QEEQVVRQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- M_musculus_ENSMUSP00000046830 -------------REEQVIKQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- R_norvegicus_ENSRNOP00000018405 -------------REEQVIKQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- A_aegypti_AAEL004526-PA -------------RKEVLLQEQELNN------------------LLQDKKLLKAL-------RLALNLDRPLMTLKIITSVIKSQ----------------------------------- P_pygmaeus_ENSPPYP00000001131 -------------MEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETV-------KAAERIMEAIELYREETAKMKEH-----KAICKAAGKEVPLPS-NPILMAYGSISPSA P_troglodytes_ENSPTRP00000053800 -------------QEEQVVRQQELDN------------------LLHEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- M_mulatta_ENSMMUP00000011166 -------------MEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETV-------KAAERIMEAIELYREETAKMKEH-----TAICKAAGKEVPLPT-NPILMAYGSISPSA R_norvegicus_ENSRNOP00000026726 -------------LQREAEYEESVAKEEQPAVPGETQG----DNYFTGKKTIETV-------KAAERIMEAIELYREETAKMKEH-----RAICRAAGKEVPLPV-NPILMAHGNISPSA O_anatinus_ENSOANP00000015573 -------------QEEEILKQQELSN------------------LLHEKRYLQAL-------GLAISLDRPHTVLTVVTAILREA----------------------------------- T_guttata_ENSTGUP00000013749 -------------MQREAEYEESVAKEEQPVVPGERQG----ETGLAGKKTIETI-------KAAERIMEAIELYREETAKLKEH-----NAICKAAGKEVPFPV-NPILRAYGNITPSA C_familiaris_ENSCAFP00000028736 -------------REEEVVKQQELDN------------------LLYEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- X_tropicalis_ENSXETP00000015707 -------------EDEAILKQQELSN------------------LLHEKRFLKAL-------GLAISLDQPHTVLTVVKAILQEP----------------------------------- E_caballus_ENSECAP00000009299 SLVWYSAHTLIVLSADEKVSEWQVEWQKDSTPGNFSLH--LKQVLQEDLGFLTGM-------ALAPDGHSLILAKADLHLLRMKPGDAPSEIWTSFGEHPIML-STHQDYGVFILQPTAS M_domestica_ENSMODP00000006461 -------------MQREAEYEDSVAKEDQPVVPGEAQG----DSYFPGKKTVETV-------KAAERIMEAIELYREETAKMKEH-----EAICKAAGKEVPLPV-NPILMAYGNILPSA M_musculus_ENSMUSP00000006444 HLIWYSANSFFVLSANENVSEWQVGLRKGSTSTSSSLH--LKRVLQEDWGVLTGL-------GLAPDGQSLILMKEDVELLEMKPGSIPSSICRRYGVHSSIL-CTSKEYGLFYLQQGDS H_sapiens_ENSP00000308179 -------------MEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETV-------KAAERIMEAIELYREETAKMKEH-----KAICKAAGKEVPLPS-NPILMAYGSISPSA T_rubripes_ENSTRUP00000006345 -------------MEREAEFEESMSKGDIPVVPGEAPG----EAAPAGKKTIETV-------KAAERIMEALELFKDENRKMEEH-----KYVCEAAGKQLPPPNPNPILVAFGNISPSR E_caballus_ENSECAP00000017445 -------------REEQVVKQQELDN------------------LLQEKRYLRAL-------GLAISLDRPHTVLTVIQAIRRDP----------------------------------- 2890 2900 2910 2920 2930 2940 2950 2960 2970 2980 2990 3000 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 -------------LERSKSRTSLIEKDRTTTLTQSNAPPPQ--------------KSNMCTLL--------------------------------------------------------- C_intestinalis_ENSCINP00000010464 -VMFFYFRLRDIELEESLLVLPFSYVPDLLQLLGTFVARGR---------EVELACRCIFFLLRIHHGRIT------------------------------------------------T M_domestica_ENSMODP00000008927 NVLSIHQQTESSVLEHIKDFDLQLENPRGTPLWITQAKPESGFNSALGMADSAFLCASSEGVLWNMAECTPEGDWVT------------------------------------------D M_domestica_ENSMODP00000027702 --------EGPKKLEEKVLKLRKDQKEALLRFLVTWNTNSR---------HCHEAQAVLGVLLQHES----------------------------------------------------- T_nigroviridis_ENSTNIP00000004057 --------DNSELLEKTVLKLRVDQKEALLRFCVAWNTNAK---------NCQDAQVVLQVLLTHVP----------------------------------------------------- T_guttata_ENSTGUP00000006840 --------EGRRHLEENIVRLRKDQKEAVLAFLVTWNTNSR---------NCHEAQAVMETLLKHEA----------------------------------------------------- B_taurus_ENSBTAP00000001564 QVLPFSGQKELGEFEECLEFDLNLENPSNTLISVTQAKPGS---------ESSFLCASSDGMLWNLARCTDEGEWIT------------------------------------------D H_sapiens_ENSP00000262715 GVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGILWNLAKCSPEGEWTT------------------------------------------G C_intestinalis_ENSCINP00000019387 --------DGYDFLNKYLSILRLDQKSELLKFVVSWNTNSR---------NCHEAHAVLKALLSNTA----------------------------------------------------- G_gallus_ENSGALP00000008904 --------DGRKRLEENIARLRKDQKEAVLTFLVTWNTNSR---------NCHEAQAVIETLLKHEA----------------------------------------------------- P_troglodytes_ENSPTRP00000010340 GVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTT------------------------------------------G S_cerevisiae_YLR222C TEEGKIEVIFNEELDQAISILNDEQLILLMKRCRDWNTNAK---------THTIAQRTIRCILMHHN----------------------------------------------------- G_aculeatus_ENSGACP00000015863 --------DSHKLLEKTVLKLRVDQKESLLRYCAVWNTNAR---------NCQDAQAVLQVLLTHLP----------------------------------------------------- B_taurus_ENSBTAP00000027147 --------ESCEKLETTVLQLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRHEA----------------------------------------------------- A_gambiae_AGAP009615-PA ----------EQGLEDTVRKLSNDHKERLLRHAIEWNTNSK---------NCRPAQLALNVLLQETL----------------------------------------------------- D_rerio_ENSDARP00000023281 YVLEVMKKVRSSELEVSLLVLPFPYVPDLLKLFNAYVKEGL---------EVELVCRCLFFLLRVHFGQIT------------------------------------------------S T_rubripes_ENSTRUP00000017221 --------DSSELLEKTVLKLRVDQKEALLRYCGVWNTNAK---------NCQDAQVVLQVLLTHVP----------------------------------------------------- A_gambiae_AGAP004827-PA EALWNKRSPPRRRLNASLSRQSSLVEDRIDSSDEDEFQEERAGM--SKKLALFHASRPLSLSV--DAWNCSSLYSSTSSTNTQY---NQPNHHQQHHYYQHHHRH----------QPDLL A_aegypti_AAEL001276-PA EALWNKRSPPRRRVNASLSRQSSLVEDRIESSDEDEFLEERAGT--SKRHK-FISMRPVSLPV--DAWHYSSFFHSS------F---THHHHHNQNQSHQH---------------PDLL M_mulatta_ENSMMUP00000021364 GVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTT------------------------------------------G P_pygmaeus_ENSPPYP00000006332 GVLYLLTQNESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTT------------------------------------------G O_anatinus_ENSOANP00000004860 YVLEVLKKVKSSELEESLLVLPFSYVPDLLLLFNQFIQLGQ---------DVELLCRCLLFLLRVHFGQIT------------------------------------------------N D_melanogaster_FBpp0085899 EALWNKRSPPRRRHNAGLSRQTSLVEDRLESSDDDEYQDERAGMLSASYDNIHHLARLPGLRSLHDAWKTNSLRVPSRSARTKFYVSTPPPQNSQNSSSLRLDSHVPGQFTDGVVAPDLV O_latipes_ENSORLP00000010395 YVLDVIKAVRSSELEVSLLVLPFPYVPELLQLFSSYIHQGL---------EVELVCRCLFFLLKIHFGQIT------------------------------------------------S R_norvegicus_ENSRNOP00000012235 GSLSILEQEESGKFEKTLDFNLNLNNPNGSPVSITQAEPES---------GSSLLCATSDGMLWNLSECTPEGEWVV------------------------------------------D S_cerevisiae_YCR057C LINKVYEAIPIKEIPLVASNIPAIYLPRILKFIGDFAIESQ---------HIEFNLIWIKALLSASGGYINE-----------------------------------------------H G_gorilla_ENSGGOP00000009169 --------EACEKLEATMLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRREA----------------------------------------------------- T_nigroviridis_ENSTNIP00000007980 YVLDVIKKVRSSELEVSLLVLPFSYVPELLKLFNAYIQQGL---------EVELVCRCLFFLLRIHFGQIS------------------------------------------------S H_sapiens_ENSP00000331815 --------EACEKLEATMLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRREA----------------------------------------------------- M_mulatta_ENSMMUP00000010429 --------EACEKLEATMLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRREA----------------------------------------------------- X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001997 YVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------DVELICRCLFFLLRIHFGQIT------------------------------------------------S P_pygmaeus_ENSPPYP00000007898 --------EACEKLEATMLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRREA----------------------------------------------------- M_musculus_ENSMUSP00000046830 --------EACEKLEATVLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRHEA----------------------------------------------------- R_norvegicus_ENSRNOP00000018405 --------EACEKLEATVLRLRRDQKEALLRFCITWNTNSR---------HCHEAQAVLGVLLRHEA----------------------------------------------------- A_aegypti_AAEL004526-PA ----------EQGLPDTIQKLRNDHKETLLKHAIEWNTNSK---------NCRPAQLVLNILLQQML----------------------------------------------------- P_pygmaeus_ENSPPYP00000001131 YVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------DVELICRCLFFLLRIHFGQIT------------------------------------------------S P_troglodytes_ENSPTRP00000053800 --------EACEKLEATMLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRREA----------------------------------------------------- M_mulatta_ENSMMUP00000011166 YVLEIFKGIRSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------DVELICRCLFFLLRIHFGQIT------------------------------------------------S R_norvegicus_ENSRNOP00000026726 YVLETFKGIRSSELEEALLVLPFSYVPDILTLFNGFIQTGS---------DVELLCRCLFFLLRIHFGQIT------------------------------------------------S O_anatinus_ENSOANP00000015573 --------DGPKKLEENIMRLRQDQKGQGVAWWGRDTWTRV---------RGNVWRRGLGAMPGAIP----------------------------------------------------- T_guttata_ENSTGUP00000013749 YVLEVFKKVKSSELEESLLVLPFSYVPDLLRLFNEYIQQGS---------DVELLCRALLFLLKIHFGQIT------------------------------------------------G C_familiaris_ENSCAFP00000028736 --------EACKKLGATVLRLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRHEA----------------------------------------------------- X_tropicalis_ENSXETP00000015707 --------HGKDDLEKNIERLRQDQKESILRYCCVWNTNSR---------NCHEAQSVLSIILTHEP----------------------------------------------------- E_caballus_ENSECAP00000009299 GALSVLRQKESGEFEETLDFCVNLENPGGTLTLVTQAKPES---------ESSFLCASSDGMLWNLAKCTLEGQWTT------------------------------------------D M_domestica_ENSMODP00000006461 YVLEVFKGIKSSELEEALLVLPFSYVPDILKLFDEFFQLGS---------NIELLCRCLFFLLRIHFGQIS------------------------------------------------S M_musculus_ENSMUSP00000006444 GLLSILEQKESGEFEEILDFNLNLNNPNGSPVSITQAKPES---------ESSLLCATSDGMLWNLSECTSEGEWIV------------------------------------------D H_sapiens_ENSP00000308179 YVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------DVELICRCLFFLLRIHFGQIT------------------------------------------------S T_rubripes_ENSTRUP00000006345 YVLDVIRKVRSSELEVSLLVLPFSYVPELLKLFNGYIQQGL---------EVELVCRCLFFLLRIHFGQIS------------------------------------------------S E_caballus_ENSECAP00000017445 --------EACEKLEATVFQLRRDQKEALLRFCVTWNTNSR---------HCHEAQAVLGVLLRHEA----------------------------------------------------- 3010 3020 3030 3040 3050 3060 3070 3080 3090 3100 3110 3120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 NQTLVNV------------------------------LDDLRHNTETKIDQLRNTIGFNLAALGHIRRQFESKNDVTFFSDATQRANDKKKRRKRTTQRAVLTT---------------- M_domestica_ENSMODP00000008927 NIWQDTEE-----------------------------EFDFPKLKTQYSKKIHSGSVTALHVLPKVLLTASEDRDVKLWEKPNLQLRGLFRCEGAVSCVEPRPGPGPTLQLAVGDAQGHV M_domestica_ENSMODP00000027702 -----------------------------------------PEELLTYEGIQASLEALLPYTERHFQRIGRTLQAAMFLDFLWQTMKLPETSAIPT------------------------ T_nigroviridis_ENSTNIP00000004057 -----------------------------------------PEELLQYQGARTHLEALVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSS-DASVTRRVSARIQA-----KEGNRA T_guttata_ENSTGUP00000006840 -----------------------------------------PDSLLQFSGIKSAVESLLPYTERHFQRLSRLLQASTFIEFMWQNMRLA------------------------------- B_taurus_ENSBTAP00000001564 NIWQKKAEMPSTQSSETESCIC----------TNTYSWSTVTELKTQQRRKIHSGPVTALHVLPELLVTASKDRDVKLWERPSMRLLGLFQCEGAVSCLEPWLGPDSTLQLAVGDTQGNV H_sapiens_ENSP00000262715 NMWQKKANTPETQTPGTDPSTCRESDASMDSDASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNV C_intestinalis_ENSCINP00000019387 -----------------------------------------PEDFEQIENYQSVIESLLPYTERHFHRMNKISQQATFVDYTWQLIKMK------------------------------- G_gallus_ENSGALP00000008904 -----------------------------------------PDNLLQYSGIKSAVESLLPYTERHFQRLSRLLQASMFIDFMWQNMKLSDVSQQEDMIL--------------------- P_troglodytes_ENSPTRP00000010340 NIWQKKANTPETQTPGTDPSTCWESDASMDSHASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNV S_cerevisiae_YLR222C -----------------------------------------IAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDKLF------------------------------ G_aculeatus_ENSGACP00000015863 -----------------------------------------PEELLQYQGARTHLEGLIPYTERHMQRIGNLLQASMFLNYMWQKMRVAGAPSSMNRDEEMDTTPLAQPFLMIDKDEDPN B_taurus_ENSBTAP00000027147 -----------------------------------------PDELLTYDGVRASLEGLLPYTERHFQRLSRMLQAATFLDFLWHNMKLPALPTAPAAL---------------------- A_gambiae_AGAP009615-PA -----------------------------------------AGRF-QVSELNKHLEASLPYTERHFKRLTEYVKDLKFVEYSLRCMQPHAARMD-------------------------- D_rerio_ENSDARP00000023281 NQMLLSV------------------------------IDELRANTISKVREIRDVLGFNSAGLQFLQREIESREDVTFFADATDRFEEKRRKRRKRERVILTIT---------------- T_rubripes_ENSTRUP00000017221 -----------------------------------------PEELLQYQGARTHLEGLVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSSMDQDEEMDTSPLVQPFFTIDKDSEES A_gambiae_AGAP004827-PA REVLLLKKQHSVPTG-------GTSGYSGDPFGGQLKLSSTETDLQALFRHC-TFGTLSCHSRRR--QSSPENEQYHVRRRMSRSIDNLNHEVAVFNQQCRRN----------------- A_aegypti_AAEL001276-PA REVLLLKKQHSTPAPTLPHDDIGLTGSSVES-RRKLKMSSTETDLQSFFGNCTTFGSLYCNARRKHAQQSPECESRAYMRRQSRSIENLR-----YGDEARLR----------------- M_mulatta_ENSMMUP00000021364 NIWQKKANIPETQTPGADPSTCRESD------ASMDSEP-TSQLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNV P_pygmaeus_ENSPPYP00000006332 NIWQKKANTPETQIPGTDPSTCREPDASMNTDASMDSEP-TPHLKTRQRRKIHSGSVTALHVAPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGTDSTLQLAVGDVQGNV O_anatinus_ENSOANP00000004860 NQMLVPA------------------------------IEKLKETTVSKVGHVRDNIGFNIAGLEFLKREIEAREDVTFFADATDRVAERRRKRKKREKLVLAMT---------------- D_melanogaster_FBpp0085899 RDLLSVPPTVESPQR--------------ISLRQLLHWPSLKSRIWRRQRNC---QSLQPNIRLNPPERLRPTPIIVVENYDVRRVQQLRTDLILHPQTSRASVGHIEVAGSEHLLAKKA O_latipes_ENSORLP00000010395 NQMLLSV------------------------------IDDLHSVTVSKVCEIRDVMGFNSAALQFLQRQIESQENVTFFAEATGRQTMNNREQKITQRSTINRS---------------- R_norvegicus_ENSRNOP00000012235 NIWQKKSRNPKSRTPGTDSSPGL---------FCMDSWVEPTHLKARQCKKIHLGSVTALHVLPGLLVTASEDRDVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDAQGNL S_cerevisiae_YCR057C KYLFSTA------------------------------MRSIQRFIVRVAKEVVNTTTDNKYTYRFLVSTDGSMEDGAADDDEVLLKDDADEDNEENEENDVVMESDDEEGWIGFNGKDNK G_gorilla_ENSGGOP00000009169 -----------------------------------------PEELLAYEGVRAALEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLPVPAAAPTPWETHKGALP-------------- T_nigroviridis_ENSTNIP00000007980 NQMLLTV------------------------------MDQLRTNTLARVGQIRDVMGFNSAALQFLQRELESKEEVTFFAEATGKLKKVKLKGRRVEPRVSDLN---------------- H_sapiens_ENSP00000331815 -----------------------------------------PEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAFLDFLWHNMKLPVPAAAPTPWETHKGALP-------------- M_mulatta_ENSMMUP00000010429 -----------------------------------------PEELLAYEGVWAALEALLPYTERHFQRLSRTLQAAAFLDFLWHNMKLPVLAATPTPWETHKEALP-------------- X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001997 NQMLVPV------------------------------IEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT---------------- P_pygmaeus_ENSPPYP00000007898 -----------------------------------------PEELLTYEGVRAALEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLPVLATAPTPWETHKGALP-------------- M_musculus_ENSMUSP00000046830 -----------------------------------------PEELLAYDGVRGSLEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLSPCPAAAPPAL--------------------- R_norvegicus_ENSRNOP00000018405 -----------------------------------------PEELLAYDGVRGALEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLSPLPAAPPAL---------------------- A_aegypti_AAEL004526-PA -----------------------------------------SGEF-QVSELNKHLEAALPYTERHFKRMTEYAKDLKFIEYTLHCMQPHATTREANKTDKV------------------- P_pygmaeus_ENSPPYP00000001131 NQMLVPV------------------------------IEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT---------------- P_troglodytes_ENSPTRP00000053800 -----------------------------------------PEELLAYEGVRAALEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLPVPAAAPTPWETHKGALP-------------- M_mulatta_ENSMMUP00000011166 NQMLVPV------------------------------IEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT---------------- R_norvegicus_ENSRNOP00000026726 NQMLVPV------------------------------IEKLKETTISKVRQVQDVIGFNMAGLNYLKRECEAKSEVMFFAEATSHLEEKKRKRKNRRKMILTLT---------------- O_anatinus_ENSOANP00000015573 ---------------------------------------------------SMSLTDPSPSPDRHFQRLGRLLQAAMFVDFMWQNMRL-------------------------------- T_guttata_ENSTGUP00000013749 NQMLVTV------------------------------IENLKKTAISRVSEARDVLGFNMAGLQFLKREIEAKEEVTFFADATERFEEKKRKRKKKEKMVLAVL---------------- C_familiaris_ENSCAFP00000028736 -----------------------------------------PEELLAYPGVQASLEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLPTLPTAPSVAPSAL------------------ X_tropicalis_ENSXETP00000015707 -----------------------------------------PESLLQFSGIRGSLESLIPYTERHMQRMGRLLQASMFVDFMWQHMRLTDLPEEDKAPGSI------------------- E_caballus_ENSECAP00000009299 NIWQKEAKMPETQTPGTDPSID----------TDVDSWPRTTDLKTQQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGAVSCLEPWLGPDSTLQLAVGDMQGNV M_domestica_ENSMODP00000006461 NQMLVPV------------------------------IEKLKKTTISKVSEVRDIIGFNMAGLEFLKRECEAKSEVEFFSDATNSFEEKKRKRKKREKLIMTLA---------------- M_musculus_ENSMUSP00000006444 NIWQKKAKKPKTQTLETELSPHSELD------FSIDCWIDPTNLKAQQCKKIHLGSVTALHVLPGLLVTASKDRDVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDTQGNL H_sapiens_ENSP00000308179 NQMLVPV------------------------------IEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT---------------- T_rubripes_ENSTRUP00000006345 NQMLLTV------------------------------MDQLRTNTVAQVRQIRDVMGFNSAALQFLQREIESREEVTFFAEATGKLKERKRRRTKRERVVLTIA---------------- E_caballus_ENSECAP00000017445 -----------------------------------------PEELLAYEGVRASLEALLPYTERHFQRLSRTLQAATFLDFLWHNMKLPTLPAAPPPWATQECAQP-------------- 3130 3140 3150 3160 3170 3180 3190 =========+=========+=========+=========+=========+=========+=========+== M_musculus_ENSMUSP00000020157 ------------------------------------------------------------------------ E_caballus_ENSECAP00000022364 ------------------------------------------------------------------------ B_taurus_ENSBTAP00000028867 ------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000042795 ------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005543 ------------------------------------------------------------------------ H_sapiens_ENSP00000353059 ------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000010869 ------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038848 ------------------------------------------------------------------------ C_familiaris_ENSCAFP00000009806 ------------------------------------------------------------------------ O_anatinus_ENSOANP00000008896 ------------------------------------------------------------------------ M_domestica_ENSMODP00000009538 ------------------------------------------------------------------------ T_guttata_ENSTGUP00000009081 ------------------------------------------------------------------------ G_gallus_ENSGALP00000037436 ------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012965 ------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014654 ------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008216 ------------------------------------------------------------------------ D_rerio_ENSDARP00000008347 ------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010200 ------------------------------------------------------------------------ T_rubripes_ENSTRUP00000033561 ------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013938 ------------------------------------------------------------------------ G_aculeatus_ENSGACP00000026214 ------------------------------------------------------------------------ O_latipes_ENSORLP00000019346 ------------------------------------------------------------------------ C_elegans_Y45F10B.10 ------------------------------------------------------------------------ C_intestinalis_ENSCINP00000010464 ------------------------------------------------------------------------ M_domestica_ENSMODP00000008927 YFLSWE------------------------------------------------------------------ M_domestica_ENSMODP00000027702 ------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000004057 NSQQH------------------------------------------------------------------- T_guttata_ENSTGUP00000006840 ------------------------------------------------------------------------ B_taurus_ENSBTAP00000001564 YFLSWE------------------------------------------------------------------ H_sapiens_ENSP00000262715 YFLNWE------------------------------------------------------------------ C_intestinalis_ENSCINP00000019387 ------------------------------------------------------------------------ G_gallus_ENSGALP00000008904 ------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000010340 YFLNWE------------------------------------------------------------------ S_cerevisiae_YLR222C ------------------------------------------------------------------------ G_aculeatus_ENSGACP00000015863 DAVKEDEDDEEVSASNKASTNTGSVENGASPQTDGNHHCESEQSSEEEDPEEVNVMKCLPVPTALKCQTFAS B_taurus_ENSBTAP00000027147 ------------------------------------------------------------------------ A_gambiae_AGAP009615-PA ------------------------------------------------------------------------ D_rerio_ENSDARP00000023281 ------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017221 -SEEEDMDEEEEEAGKAAKRL--------------------------------------------------- A_gambiae_AGAP004827-PA --------------------PMSRS---------------------------CLMQ---------------- A_aegypti_AAEL001276-PA --------------------RKYRS---------------------------CLMQ---------------- M_mulatta_ENSMMUP00000021364 YFLNWE------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000006332 YFLNWE------------------------------------------------------------------ O_anatinus_ENSOANP00000004860 ------------------------------------------------------------------------ D_melanogaster_FBpp0085899 NYWQRRWHLLRHKAASTTTTTTSRSESSHPHRDSMNSHSNNSTPDPTANCNDCVAQ---------------- O_latipes_ENSORLP00000010395 ------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000012235 YFLSWE------------------------------------------------------------------ S_cerevisiae_YCR057C LPLSNENDSSDEEENEKELP---------------------------------------------------- G_gorilla_ENSGGOP00000009169 ------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007980 ------------------------------------------------------------------------ H_sapiens_ENSP00000331815 ------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010429 ------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035244 ------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001997 ------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007898 ------------------------------------------------------------------------ M_musculus_ENSMUSP00000046830 ------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018405 ------------------------------------------------------------------------ A_aegypti_AAEL004526-PA ------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001131 ------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000053800 ------------------------------------------------------------------------ M_mulatta_ENSMMUP00000011166 ------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026726 ------------------------------------------------------------------------ O_anatinus_ENSOANP00000015573 ------------------------------------------------------------------------ T_guttata_ENSTGUP00000013749 ------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028736 ------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015707 ------------------------------------------------------------------------ E_caballus_ENSECAP00000009299 YFLSWE------------------------------------------------------------------ M_domestica_ENSMODP00000006461 ------------------------------------------------------------------------ M_musculus_ENSMUSP00000006444 YFLSWE------------------------------------------------------------------ H_sapiens_ENSP00000308179 ------------------------------------------------------------------------ T_rubripes_ENSTRUP00000006345 ------------------------------------------------------------------------ E_caballus_ENSECAP00000017445 ------------------------------------------------------------------------