>M_musculus_ENSMUSP00000005488 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MESEMSDPQPLQE---------------------------------- ------------------------------------------------------------ ---------------------------ERYDMSGARLALTLCVT---------------- ---KAREGSEVDMEALERMFRYLKFESTM-KRDPTAQQFLEELDEFQQTIDNWEEPVSCA FVVLMAHGE-E-------GLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRG -------------EHR-DPGEELRGNEELGGDEEL-----GGD---------------E- VAVLKNNP-QSIPTYTDTLHIYSTVE--GY-------------------------LSYRH DEKGSGFIQTLTDVFI-------H----KKGSILELTEEITRLMANTEV-----MQEGKP RKVNPEVQS-----TLRKKLYLQ----------------------- >R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MDSETINPQPLQE---------------------------------- ------------------------------------------------------------ ---------------------------ERYDMSGARLALTLCVT---------------- ---KAREGSEVDMDALERMFQYLKFESTM-KRDPTAQQFLDDMDEFQQTIENWKEPVSCA FVVLMAHGE-E-------GFLKGEDGNMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRG -------------EHR-DPG------------EEL-----PGD---------------EL AVIKKKNP-PTIPTYTDMIHIYSTVE--GF-------------------------LSYRH DQKGSGFIQTLTDVFI-------H----KKGSITELLEEITRLMANTEV-----MQEGKP RKVNPEIQS-----TLRKKLYLQ----------------------- >H_sapiens_ENSP00000221740 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSNPRSLEE---------------------------------- ------------------------------------------------------------ ---------------------------EKYDMSGARLALILCVT---------------- ---KAREGSEEDLDALEHMFRQLRFESTM-KRDPTAEQFQEELEKFQQAIDSREDPVSCA FVVLMAHGR-E-------GFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRG -------------EQR-DPG------------ETV-----GGD---------------EI VMVIKDSP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRH DQKGSCFIQTLVDVFT-------K----RKGHILELLTEVTRRMAEAEL-----VQEGKA RKTNPEIQS-----TLRKRLYLQ----------------------- >C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MVDSEIRQAQLLAQ---------------------------------- ------------------------------------------------------------ ---------------------------EAYDMSGARLALTLCVT---------------- ---KAREGSEADLDALERMFQQLGFESTM-KRDPTAQQFQEELDKFQQAMDARDDFISCA FVVLMAHGL-E-------GRLKGEDGEMVELEDLFKVLNNKNCRALRAKPKVYIVQACRG -------------EQR-DPG------------ETV-----SGD---------------DI VMITKDNP-QTIPTYTDILHVYSTVE--GY-------------------------IAYRH DKEGSCFIQTLVDVFT-------E----RKGPILELLTEVTRRMAEAEL-----VQEGKP RKVNPEIQS-----TLRKRLYLQ----------------------- >B_taurus_ENSBTAP00000028116 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ESKEMSSPQPLEE---------------------------------- ------------------------------------------------------------ ---------------------------ETYDMSGARLALTLCVT---------------- ---KAREGSEADLDALERMFQQLGFESTM-KRDPTAQQFQEELEKFQQAIDAREDFVSCA FVVLMAHGL-E-------GRLKGKDEKMVELEDLFQALNNKNCRALRAKPKVYIVQACRG -------------EQR-DPG------------EPV-----TGG---------------HL VMITENTP-ETIPTYTDTLHVFSTIE--GY-------------------------IAYRH DQEGSYFIQTLVDVFI-------N----KKGPILELLTEVTRRMAEAEM-----VQEGEA KKVNPEIQS-----TLRKQLYLQ----------------------- >O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ERYDMSGARLALTLCVT---------------- ---KAREGSEADLDALERMFQQLGFESTV-KRDPTAQQFQEELEKFQQTIDAWKDPVSCA FVVLMAHGD-E-------GVLKGEDEEMVKLEDLFEVLNNKNCKALRAKPKVYIVQACRG -------------EHR-DLG------------ETV-----GED---------------QV MMITRDSP-QTIPTYTDTLHVYSTVE--GY-------------------------IAYRH DQEGSCFIQTLTDVFM-------N----RTGPILELLTEXXXXXXXXXX-----XQEGKA RKVNPEIQS-----TLRKRLYLQ----------------------- >M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSNLRSSEE---------------------------------- ------------------------------------------------------------ ---------------------------EKYDMSGARLALTLCVT---------------- ---KAREGFEEDLDALEYMFRQLRFESTM-KRDPTAQQFQEELEKFQQAIDSREDPISCA FVVLMAHGR-E-------GFLKGEDGEMVKLDNLFEALNNKNCQALRAKPKVYIIQACRG -------------EQK-DPG------------ETV-----GGD---------------EI VMVTKDSP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRH DQKGSCFIQTLVDVFT-------K----GKGHILELLTEVTRRMAEAEM-----VQEGQA KKTNPEIQS-----TLRKRLYLQ----------------------- >E_caballus_ENSECAP00000010379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------Q---------------------------------- ------------------------------------------------------------ ---------------------------EAYDMSGARLALTLCVT---------------- ---KAREGSEADLDALERMFQQLGFESTT-KRDPTAQQFQEELEKFQQAMDAREDLVSCA FVVLMAHGV-E-------GRLKGEDEQMVELESLFEVLNNKNCQALKARPKVYIVQACRG -------------EQR-DPG------------ETV-----GSD---------------DI MMIAKDSP-ETIPTYTDTLHIYSTVE--GY-------------------------IAYRH DKEGSCFIQTLVDVFT-------E----RRGPILELLTEVTRRMAEAEL-----VQEGRT RKVNPEIQS-----TLRKRLYLQ----------------------- >M_domestica_ENSMODP00000018104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DVYNMSDARLALTLCIT---------------- ---KNRAGSETDVQALEKMFKALNFKNTV-RRNIPAKGFWEELEKFRDDMDQMKDPVSCC FVVLMAHGE-E-------GILQGVDGNTIRLDELFCMLTNKNCRALRGKPKVFIVQACRG -------------DQK-DPG------------EVVKPTSSGGD----------------- VLLAKERP-PKLPTFSDSLHVYATVE--GY-------------------------IAYRH EEDGSFFIQTLVDVFT-------N----MKGNILDLLTEVTRRMADAEL-----MEEGKP RKVNPEVQS-----TLRKLLYL------------------------ >P_pygmaeus_ENSPPYP00000010831 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSNLRSLEE---------------------------------- ------------------------------------------------------------ ---------------------------EKYDMSGARLALTLCVT---------------- ---KAREGSEEDLDALEHMFQQLRFESTM-KRDPTAQQFQEELEKFQQAIDSREDPVSCA FVVLMAHGR-E-------GFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRG -------------EQR-DPG------------ETV-----GGD---------------EI VMVIKDSP-QTIPTYTDALHVYSTVE--GY-------------------------IAYRH DQK--------------------------------------------------------- ---------------------------------------------- >G_gorilla_ENSGGOP00000000424 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MSNPRSLEE---------------------------------- ------------------------------------------------------------ ---------------------------EKYDMSGARLALTLCVT---------------- ---KAREGSEEDMDALEHMFRQLRFESTM-KRDPTAQQFQEELEKFQQTIDSREDPVSCA FVVLMAHGR-E-------GFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRG -------------XXX-XXX------------XXX-----XXX---------------XX XXXXXXXX-XXXXXXXXXXXXXXXXX--XY-------------------------IAYRH DQKGSCFIQTLVDVFT-------K----RKGHILELLTEXXXXXXXXXX-----XXXXXX XXXXXXXXX-----XXXKRLYLQ----------------------- >O_anatinus_ENSOANP00000013840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LPHSSSSPQ---------------------------------- ------------------------------------------------------------ ---------------------------MVYDMSGARLALTLCIT---------------- ---KDREGAEPDIAALERMYQALRFESTV-RRDPPAKAFRDELVRFREEMEGRKDPVSCC FVVLMAHGK-E-------GHLLGADEQVVELEELYDVLTNKSCRALLGKPKVFILQACRG -------------DQK-DSG------------EML-----RTE---------------EV LTTMIQKV-PRIPTFTDTLHVYSTVE--GK-------------------------GSHCH ------------------------------------------------------------ ---------------------------------------------- >M_domestica_ENSMODP00000020556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LLLWLPQLSPIPQ---------------------------------- ------------------------------------------------------------ ---------------------------GVYDTSGAKVALVLCVT---------------- ---RDRPGAKQDLKALKRLFQTLGFKSIL-KMNPTAQDFRKELTRFRELLDARRTNVSCA LVALMAHGEPQ-------GRLLGADGQMVEVEEMVSELS--ACQVLQGKAKVVLLQGCRG -------------GNR-DPG------------MRP-----RA-----------LPWLGSW LQHWLQRP-STIPSHADILQVYANLQ--GY-------------------------VAYRN -ENGSDFIQTLVQVII-------AN---PDQDLLELLTEVNKRLCEMEV---RGPDCDEI RKMSVEIQS-----SLRKQLYLK----------------------- >E_caballus_ENSECAP00000006138 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ELAEEGGLGSGLPWGAGWLPGAAGCPWGPCGLCP SGL-APSGLLRQPQQLVQELSRCGALRGCPKVFLLLSSAPGAAPEPGAFLTSLGELCGRC PHWSLLQLLTEVFCRIAEEFSGATYCP--------------------------------V LRSSLRGALCLGDTEPWGLEPEPSPS---------------------------------- ------------------------------------------------------------ ---------------------------AQYDLSGARVALLLAVI---------------- ---RGRSGAQHDVEALWGLCQALGFETTL-MTDPTAQAFQEELAQFREWLDAHRGPVSCA LVALMAHGGPQ-------GQLLGADGQEVQPEALVRELS--CCRALRGRPKIFLLQACRG -------------GHR-DAGL--------------------------------GPTALSW FWRWLRAP-PATPSHADVLQVYADAQ--GSSSRGPTAGSSDQADILMVYAAAEGCVAYRD -ETGSDFIQTLVEVLR-------AD---PKGDLLELLTEVNRRVCELDV---LGPDSDER RKACLEIRS-----SLRRRLCLQA---------------------- >B_taurus_ENSBTAP00000045524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VEPWGPEPEPGPS---------------------------------- ------------------------------------------------------------ ---------------------------AQYDLSGARAALLLAVT---------------- ---QGRLGAQHDVEALEGLCQALGFETTL-RTDPTAQTFQEEMAQFRKRLDAHRGPVSCA LVALMAHGGPQ-------GQLLGADGQERQLEVLVQELS--HCGALRGRPKIFLLQACRG -------------GEQ-APG----------PPWRPASCCPSSP----HPALSLSGLVVHL LQRWLRAP-PATPSQADVLHVCTDVQ--GC-------------------------VAYRD -KKGSDFIQTLVEVLR-------AD---PKADLLELMTEVNRQVCELDV---LGPDCDDR RKACLEIRS-----SLRRRLCLQ----------------------- >M_mulatta_ENSMMUP00000027593 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------APGPN---------------------------------- ------------------------------------------------------------ ---------------------------TQYDLSKTRAALLLAVI---------------- ---QGRPGAQHDVEALGGLCRALGFETTV-RTDPTAQAFQEELAQFQKQLDTCRGPVSCV LVALMAHGGPQ-------GQLLGADRQEVQPEALMQELS--RCRVLWGRPKVFLLQACRG -------------GNR-DAGV--------------------------------GPTALPW YWSWLRAP-PSVPSHADVLQIYAEAQ--GY-------------------------VAYRD -DKGSDFIQTLVEVLR-------AN---PGRDLLELLTEVNRRMCEQDV---LGPDCDEL RKACLEIRS-----SLRRRLCLQP---------------------- >O_anatinus_ENSOANP00000019254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------IDSPMCHPSPGDENQ-------------------------------- ------------------------------------------------------------ ---------------------------KRYDMSKCREAFLMGVK---------------- ---KGRSGATEDIEKLRKHLAAFRFSVQE-CIDPDGKVILQDLREFRDKINGSPYEMSCC LVILMSHGV-N-------GFIKGKDEKVVDLEEIFKLFNNANCPNLREKPKIFIIQACRG GPNHRSRGIKSKIDRT-DGGV-----------EAF-----DNV---------------PE EMDDTSNV-KRLPTTSDFFIVYSTQK--GH-------------------------VSVRN PLMGSRMIEAMDDVFS-------RYG--KKWQLTDLFTKSLLKALPSLL-------EGGI VKVTLEMQS-----TLTRAVYLG----------------------- >C_familiaris_ENSCAFP00000007585 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MERSPGSGGRWEC SGPPAPPELTPDVAELQSRVQETLELLSPQDLRNFRLLLKTVDEEPRVSPVKLELEGRKK AGLARLVAQNYCEPA-ASRVLVKVLRQ--------------------------------L RRADLLRLW--QGAADRGGERIPRKILKRSYDCVDGEL---------------------- ------------------------------------------------------------ ---------------------------DRYDLSGSRKAFLMCVE---------------- ---KSRPGAHRDIELMKEWLGQCQFEHTA-CIDPNKMELLRKITLFRDGLNEIKGDVGCC LITLMSHGE-N-------GFIKMEDGEKVNLQDIFEMFNNKNCPALQEKPKIFIIQACRG --------VLQNTERR-DSGV-----ET--DDE-------------------------PM ESDDVSEK-RRLPTFSDYFIIYPTQA--DH-------------------------VALRH PRTGSVMIEAMSEVFK-------QYG--NKWHIADFFTRVNNRVVHTEFHL-----HEEP IKVSLVMES-----TLTKSVYF------------------------ >B_taurus_ENSBTAP00000012869 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MEGSLGSGRRSGS DGQPAPPKISPTTEELQSRLQETLDLLSSQELRSFRDHLKKV--EPPVSQVKLELEGHSP SGLAKLLAKHYYPAAVAKRVLVQVLEL--------------------------------L PRADLLPRW---QSAPTDCPVIPRKSLKRSYDCVDGEL---------------------- ------------------------------------------------------------ ---------------------------YRYDLSGRRKAFLMCVK---------------- ---KNRLGAHQDVQLMKDWLKECKFEPTL-CIDPDKMDLLGKITSFRDELNEIKDDIGCC LVTLMSHGE-E-------GFIKMKDGEKVSLEDIFEMFNNKNCPALQEKPKIFIIQACRG -------------ERR-DSGV-----ET--DDE-------------------------PM DLDDGSEK-KRLPTFSDYFIVYPTQA--DH-------------------------VALRD PRTGSVMIKEMTEVFK-------QYG--NKWHLADFFTIVNNRVVHRDFNL-----CNKP VKVSLVMES-----TLTKFVYF------------------------ >M_domestica_ENSMODP00000032734 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------M------------ --------LQPDMESFKAQVVSTLTKLSPEELRRFGIYLRNVGEEPRVSRHDLEM-ATKP EELADLLLKRYVMTG-TPRVLVQVLGQ--------------------------------V PRKDLALEWALRRRSPSRCKSMSRMNLKRPYEDDSSEL---------------------- ------------------------------------------------------------ ---------------------------DRYNMDRTRKAFVMCVK---------------- ---TGRPGAKQDISRIKNWLEKCKFEYTY-CDDPDEEELFEKLTQFRDGINGIKEEVSCC LVTLMAHGG-K-------GHIKTKSNERVNLSDIFEMFNNENCPALQEKPKIFVIQACRG -------------DKR-DGGV----VQA--DDE-------------------------PM EL-DLSEK-KRLPTSSDYYIIYATQD--DH-------------------------VAFRH PRDGSVMIQAIDEVFR-------QHG--KKWHIADFFTQVNNLVVHTDFYI-----NRNP AKVVLVMES-----TLTKAVYF------------------------ >O_cuniculus_ENSOCUP00000000197 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ELGEEGGLGPGLPPGASFVQEAAGCPPEPRGLCP CGPGAPRGQLRQPRQLVQELSCCEALQGCPKVVLLLSSGAGAALEPGAFLAGLRELCGRR PHWSLLQLLTELFCRVAEDSAGDIRCP--------------------------------V FQSSLRGALCLTSEEPWRPEAEPGPG---------------------------------- ------------------------------------------------------------ ---------------------------AQYDMSGARAALLLAVI---------------- ---RDRPGAERDVEALGGLCQALGFETTL-RTDPTAQAFWEKLGQFQEQLDTYRGPVSCA LVALMAHGGPQ-------GQLLGADGQEVQPEALVQELN--PCGALSGCPKVFLLQAWRG -------------GNR-DAGK--------------------------------GPKALPW YRRWLWVPQPALPSHADVLQVHADAQ--GSSCSGPAPGSSGQADVLTVYAAAEGCVAYRD -EMGSDFIQTLVDVLR-------AD---PGRDLLELLTEVNRRVCELDV---LGPDCDEP RKACLEIRS-----SLRRRLRLRV---------------------- >E_caballus_ENSECAP00000017996 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VK---------------- ---RNRPGAQHDVMLMKEWLGQCQFEHTS-CIDPDKMELLGKITSFRDGLNEIKDEIGCC LVTLMSHGE-N-------GFIKMKDDERVSLEDIFEMFNNKNCPALQEKPKIFIIQACRG -------------EKR-DSGV-----ET--DDE-------------------------PM DSDDISEK-RRLPTFSDYFIIYPTQA--DH-------------------------VALRH PRTGSVMIEAMAEVFK-------QHG--NRWHIADFFTRVNNRVVHTEFHL-----REEP IKVSLVMES-----TLTKSVYF------------------------ >A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DHYGMKKKRVAFMMCVT---------------- ---EGRAGAEEDIKKMKKWFRTFKFTLLGDCRNPGQETLMQQLRQFRDIINLSNEEISCC LITLMSHGKAN-------GYILDKDNREISLDGIFSLFNNKTCPKLQGKPKIFIIQACRG -------------EQR-DYGT----LVA--GGKPV------------------------- -EPDTWSR-PKLPTVSDYFIVYSSQR--DH-------------------------IAVRD ENTGSEMISAMDEVFS-------EHG--TQWHIGDLFTKVNSKMIQRDFHL---EGEEES VKVTIVMES-----TLTKALYL------------------------ >M_domestica_ENSMODP00000001598 --------------------------------------------------------RMLG VWGMEQEHQEALKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVGS--FSQNVEFLNLLPKRGPH AF----EAFCDALRETKQGHLEDLLHR-------TLYS--------FQ------------ --NLRPPLGCDYDSSFPLPVCDSC-----------------PPHKQLRLSV-ETMEH--- ----------------------------------------------------------SL DNGDGPPSLQ--VKPCTPEFYQTHQH-LAYRLQSRPRGLAMVLSNVHFN--GEK------ -DLEFRSGGDVDHSSLVTLFKLLDYDVHV-LRDQTAQKMQENLQRFAQLSA--HQSTDSC MVALLSHGI-E-------GGIYGVDGKLLQLQEVFRLFDNANCPNLQNKPKMFFIQACRG -------------DET-DRGV----DLR--DGKEHVASPGCEE-SDAGKE---------- ----KILK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALTQVFS-------ERA--RDMHVADML--VNALIKDREGY--APGTEFHR SKEMSEYSS-----TLCRHLYLFPGHPPT----------------- >A_carolinensis_ENSACAP00000006831 -------------------------------------------------------SRMLG VCGMQKCHQEALKKNRVSLAKQL------------------------------------- ------------------------------------------------------------ -----------VLKELMEHLIEKD-VITEEMMEMIQAKAGN--FSQNIEFLNLLPKRGPK AF----SAFCEALRETKQPHLEEMLLL-------NLID---------------------- --FLLFHHVIVPPQNAHLPLHTVCDLL--------------PFAYQLFISSAEPMEH--- ----------------------------------------------------------SL DDGDGPHYPQ--VMPCTPEFYRTHEQ-LAYKLKSQPRGLALILSNIHFN--KET------ -DLDFRSGGDVDNTALHMLFKHLGYQVVV-RQDRTAQEMKEELEIFSKHPA--HRNVDSC IVSLLSHGI-E-------GGIYGIDGKLLQLQEIFRLFDNANCPNLQNKPKMFFVQACRG -------------DET-DHGV----DQI--DGNDRASSPGCEE-TDANKK---------- ----ENPK-LRLPTCSDMICGYACLK--GT-------------------------AAMRN TKHGSWYVEALTSVFA-------EDS--GHMHVADMLVKVNRLIKLREGH--APGTEFHR CKEMSEYCS-----TLCQDLYLFPGYFPG----------------- >M_domestica_ENSMODP00000005556 -------------------------------------------------------MEDTG TTVDAKS----TKNS--------------------------------------------- ------------------------------------------------------------ ---------------------GVKLFHGSKSVES----GLS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------S-DSYKMDYPEMGLCIIINNKNFH--PNT------ -GMSFRSGTDVDAASLSDTFRSLKYEVRI-KNDLTCNEITELLNSVSKE-D--HSQRSSF ICVILSHGE-E-------GVIFGTDR-SVELKRLTCFFRGDKCRSLTGKPKLFIIQACRG -------------TEL-DCGV-----ET--D-SGT------------------------- --DEDIAC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQALCAVLK-------QHA--HKLEIMQILTRVNRKVATEFESY-SLDISFHA KKQVPCIMS-----MLTKELYF-S---H------------------ >O_anatinus_ENSOANP00000015596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AGTRRDQARQLVTDLETRGRR AL----SVFISCLRETDQHALAALLSE--------------------------------G -----CQAPQVTP-----VDIRPVEIIRPGGQGDVCKYSK------------IHPKCYSP PLPFQSTSPLRGKEQWTGSVKPFV--------------------PVPSTTKREQEATR-- PGE-----------------KQGMAI-KVYSLKSEPCGHCLIINNVDFS--LGS------ -GLSTRTGSDVDCEKMKRRFRLLHFEVAV-ERNLTAEEMVKALNKLAKK-D--HSALDCC VVVILSHGY-QASHIQFPGGIHGTDGESISVETIVNYFNGSRCPSLGGKPKLFFIQACGG -------------EKK-DPGF---EVNL--D-SPEDHPTGSDP-ESDAAPFQAAPEDY-- --DEPDAV-ASLPTPSDILVSYSTFP--GF-------------------------VSWRD TQSGSWYIETLDSVLD-------QWA--HTEDLLTLLLRVSNGVS-----------SKGK YKQIPGCFN-----FLRKRLFF-NT--K------------------ >X_tropicalis_ENSXETP00000015203 -----------------------------------------------------------M LGGMQKHHKDALQRLRVTLLHDM------------------------------------- ------------------------------------------------------------ -----------IIEELVEHLVSSG-ILTPIMHSTIMAHRSE--YKQNVTLLTQLPKRGPR AF----SEFCNALHATGQRHLAEQLEE-------EAQQQQ------ME------------ -----SVTPEVHERSFPLPVQEST-----------------PSRPRRQFCR-EYNEE--- ----------------------------------------------------------SI DDGDGPGT----VQLCSVDFYLSHHQ-QAYKMHSCPRGRALIISNVAFE---TQ------ -DLDHRYGGEVDVTSLEKLFSSLGFQVEV-RRNLNAQNMMSQLGAFSALPA--HSALDSC VVAVLSHGL-D-------GAVYGTDGKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQACRG -------------EEA-DRGV----DQR--DGREQSASPGCEQ-SDAGRE---------- -----DIK-VRLPTQSDMICAYACLK--GT-------------------------VSLRN TKRGSWFVQDLVSVFS-------QYS--KNTHVADMLVKVNALIKEREGH--APGTEFHR CKEMSEYCS-----TLCRDLYLFPG--------------------- >O_anatinus_ENSOANP00000000517 -------------------------------------------------------AASGE VMVDSKS----FHSS--------------------------------------------- ------------------------------------------------------------ ------------------QGYSSRKVPGKQFLGS----SAS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-DRYRMDYPNMGICLIINNKNFH--PDT------ -RMGCRSGTDVDAASLRDTFKKLKYEVRC-KNDLKRREILELLTSVAHE-D--HSKRSSF VCVLLSHGE-E-------GVIFGTDG-SLELKSLASLFRGDNCRSLVGKPKLFIVQACRG -------------TEL-DSGV-----EA--D-SSS------------------------- --ADDGSE-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SMNGSWFIQALCAMLK-------QHA--HTLELLHILTRVNRKVATEFESY-SLDATFNA KKQIPCIVS-----MLTKELYF-P---Y------------------ >A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FRYRMDYKKLGKCVIINNKNFA--KDT------ -GMRIRNGTDKDAGDLQKCFRGIGFDVSI-YNDLTCDNMEKILGEAALE-N--HDDAACF ACILLSHGE-E-------GLIYGTDG-CMAIKNLTGLFRGDKCQSLIGKPKLFFIQACRG -------------SEF-DAGI-----QT--D-SGS---SN-DN----------------- LEMDANPR-YKIPVEADFLYAYSTVP--GY-------------------------FSWRN PGKGSWFVQSLCSVLN-------DHG--KELEVLQILTMVNYKVARNYESQ-SDDPRFSQ KKQVPCVVS-----MLTKELYF------------------------ >O_anatinus_ENSOANP00000005545 ------------------------------------------------------------ ---MQPCHQEALKKNRVALAKQL------------------------------------- ------------------------------------------------------------ -----------MLSELLEHLLEKD-VITMEMRELIQAKAGS--FSQNVEFLNLLPKRGPK AF----DAFCAALRETKQGHLQDLLYR-------TLSN--------LSPPSTAVGALGTQ GEELAGRLGGRWRGLPSLPSVSVCPVVVCPFLMVLGNSRLQPALSVGDLLP-EEMEH--- ----------------------------------------------------------SL DNGDGPPCPQ--VKPCTPEFYRVHHH-LAYRLESRPRGLALVLSNMRFN--GEK------ -DLEFRSGGDVDHNALITLFKHLDYSVEF-LRDQTAQEMQEKLHNFAQSPR--HRFTDSC VVALLSHGV-E-------GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQR--DGKERAASPGCEE-SDAGKE---------- ----EMLK-VRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALTQVFA-------ESA--RDMHVADMLVKVS------------------- ---------------------------------------------- >T_guttata_ENSTGUP00000013612 ---------------------------------------------------------MLA ACGMQRCHQEALKKNRVMLAKQL------------------------------------- ------------------------------------------------------------ -----------VLNVLVEHMVEKD-IIPTEMVEMIQAKSGS--FDRNVEFLNLLPKRGPN AF----SAFCEALRETQQQHLETLILK-------TMSS--------LS------------ --QEIARLEHCHESDLPYPASESCNSK--------------RPRWL------EPMEH--- ----------------------------------------------------------SL DNRDGPSIPP--VKYCTPEFYHNHQH-LAYKLTSEPRGLALILSNVRFS--SEK------ -DLEYRAGGDVDCASLEMLFRHLGYRVTV-FCDQTAQDMQNALERFSKLQD--HRDVDSC IIALLSHGV-E-------GGVYGSDGKLLELQETFRLFDNANCPNLQNKPKMFFIQACRG -------------DEL-DRGV----DQR--DGKGRSDSPGCEE-SDANKE---------- ----ESLK-LRLPTCSDMICGYACLK--GT-------------------------AAMRN TKRGSWYVEALTSVFA-------EDS--QHTHVADMLVKVNRQIKQREGY--APGTEYHR CKEMSEYCS-----TLCRDLYLFPGYLPGK---------------- >G_gallus_ENSGALP00000029853 -----------------------------------------------------------G ACGMQRYHQEALKKNRVMLAREL------------------------------------- ------------------------------------------------------------ -----------VLKELMEHMIEKD-IITIEMVEMIQAKSGS--FSQNVEFLNLLPKRGPN AF----SAFCEALQETKQQHLAEMILK-------TESS--------LR------------ --HGIATLEQRYGSNLPLPLSESCNSK--------------RPRLIVFFCT-KPVEH--- ----------------------------------------------------------SL DSGDGPPIPP--VKHCTPEFYRDHQH-LAYKLISEPRGLALILSNIHFS--SEK------ -DLEYRSGGDVDCASLELLFKHLGYQVTV-FHDQSAEEMESALERFSKLPD--HQDVDSC IVALLSHGV-E-------GGVYGTDGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQACRG -------------DET-DRGV----DQR--DGKEWSDSPGCEE-SDANKE---------- ----ENLK-LRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALTTVFA-------EDS--RDTHVADMLVKVNRQIKQREGY--APGTEFHR CKEMSEYCS-----TLCRDLYLFPGYVPGK---------------- >T_rubripes_ENSTRUP00000022652 ----------------------------------------GSDAELGKTATDSSACTGDL METDAISG---------------------------------------------------- ------------------------------------------------------------ -----------------------------------SIGFLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EEYKMDNKRRGLALIFNQERFF--WRL------ -GLRDRHGTNADSYNLQRRLKELNFEVKV-FDNHTQAQVLEIITSAAKD-D--HSNVDCF LVVFLSHGE-N-------DHIYTFDD-KINVQDITSLFKGDKCKSLVGKPKIFILQACRG -------------DKH-DEPA----TAAAFD-DVD---SELKK-NEV------------- -EVDASAV-YTLPAGADFIMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCDLLR-------KYG--DSLEFTELLTLVNRKVSMRSVGY-CSDPNAIG KKQVPCFAS-----MLTKKLYF-R---PKK---------------- >D_rerio_ENSDARP00000072390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------A-FEPYKKHKNIGKCLIISNEHFP--VQF------ -SLNRKKGNSVDERRLSSTFKSLGFHVKV-ENNLSANQMIDALRTVSEE-D--HTDNSCF VCVLMSHGE-E-------GTILGSDERWIPVKTLTSLLTSDLCPSLRDKPKIFFLQACRG -------------VEY-DPGV-----EA--D-SVE---AS-E------------------ ---DFFGI-SDVP-ELDFLCCYSTVE--GY-------------------------FAWRN PETGSIFIRELCKTLM-------DC----RLEIIQILTRVNHLVAYYFQSY-TLELETNR KRQMPCFAS-----RLTKDFYL-----HV----------------- >G_gallus_ENSGALP00000013571 ----------------MSSDFRKLLFDISEALATEELAALKFLSLEHVPVRKQEDTEEPK AFFEVLKEKGMIEVEDLFFLKELLYRINRIDLLASHLGSSREEMERELQVPGKAKVSAYR ------------------------------------QLLYGIAEDLTPDDVRSIKFLLQE KLPKNKLQDNASMLKVLVEMERNG-IIKEDDLTMLKSILKA-FRADLKKKIDNYEEKT-- -----------------------------------------------------------K GWPWKSSCFPNKTQALSISENLAVSSLIDNKESQESQSEWYSAGIFPPH----------- ------------------------------------------------------------ --------------------VQILLV-ESYKMENNPHGYCVILNNYRFK--NPN------ ---ETRKGTVEDGKALKRVFKWLQFDTIE-YMDLEAKQIFAKVNEYSKK-D--HSNMDCF VCFILSHGE-K-------GKIKGVDNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQACQG -------------SVG-HPAV---TVKE--D-CSGHL----------------------- -ETDAIPA-LSIPDQADVLVGMATVE--DF-------------------------ECYRS IETGSVYIQCLCDKME-------LLCP-LRKDLITILTEVNKEVGRRVL---------NG WKQMPKITS-----TLRKQFIF-Q---IPQCQ-------------- >C_familiaris_ENSCAFP00000023986 ------------------------------------------------------------ ---MDEAERRALRRCRVRLVREL------------------------------------- ------------------------------------------------------------ -----------QVAALWDALLSRE-LFTAAMVEDLQHAGSGSRSDQARQLVIDLETRGSQ AL----PLFISCLEDTGQDALASCLTM--------------------------------S -----RQAVKQNP---E--ATRPLD-LMPVVLGPTRLTPEDLR----------GKDPSKL TPGKLAPVVLG-----PAELQPQVVR-------------PSVPRPTDNGSGRFSDVCE-- YQESGWW-------------VAGPIK-LAYALNADPCGYCLIINNVNFC--PES------ -RLTARGGSNIDCEKLQRRFCLLRFTVEV-KWDLTAKQMVQALVELARR-D--HSALDCC VVVVLSHGC-EASHRQFPGAVYGTDGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQACGG -------------EQK-DHGF---AVAS--A-SPEDRSPGSDS-EPDAVPFQEGPGPF-- --DQLDAV-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRN TKSGSWYVETLDGVFE-------QWA--HAEDLQTLLLRVANAVS-----------QKGV YKQIPGCFN-----FLRKKLYF-KM--------------------- >M_domestica_ENSMODP00000036247 ------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDAL VLFQTLEERGLLEEDNLFFLKELLFRINRIDLLNEPLNTKGPEMERELQVPNKARISPYR LHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLSEGVGPSELKSIKFMLSS KIPKCKIEDDMTLMDLFIEMEKRG-ILGEGNLDALKIVCDQ-IDKSLLKKIQEYEISKGR NN---------------------------------------------------------- -----LFLIYQNTQPQEVYDS--------------------------------------- ------------------------------------------------------------ ---------------------AGEKG-NVYKMSSRPRGYCLIINNFDFK--ISRKERPEN HYLTDRRGTNKDEEALKNIFKELHFDIQS-FQDLTAEGIQQVLKTFKDN-N--HESKDCF VCCLLSHGN-K-------GTIYGIDGKEVPIRDLTSYFSGSNCPSLAGKPKVFFIQACQG -------------KAT-QYGI---SLDT--D-SEQQRESLE------------------- -ADKSFQS-ECIPNEADFLLGMATVE--NY-------------------------VSYRD SARGTWYIQSLCKNLK-------EGCL-RGNDILTILTEVNSEVSQKTD-------PKNN GKQMPQPKI-----TLRKKLVF-PIS-------------------- >T_nigroviridis_ENSTNIP00000021186 -----------------------------------------------------------R METDAFYG---------------------------------------------------- ------------------------------------------------------------ -----------------------------------RNSIVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EEYKMDNKRRGLAIIFNQESFF--WRL------ -GLKDRHGTNADSYNLQRRLRELNFDVNV-YNNYKQQEVLDIINAAAKA-D--HSDVDCF LLVFLSHGE-N-------DHIYANDD-KISIQDITSLFKGDKCKSLVGKPKIFIWQACRG -------------DKH-DEPA----TAAAFD-DVD---SESKK-NEV------------- -EVDASAV-HTLPAGADFIMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCDLLL-------RYG--DSLEFTELLTLVNRKVSMRSVGY-CRDPNAIG KKQVPCFAS-----MLTKKLYF-R---PKKKSK------------- >M_mulatta_ENSMMUP00000016588 --------------------------------------------------------RILG VCGMHPHHQETLKKNRVMLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVGS--FSQNVELLNLLPKR-PQ AF----DAFCEALRETKQGHLEDIELK-------LRVS--------AL------------ --MKPTGLGSDYNDILGLMVKLNT------------------VFWFSVYTT-DTVEH--- ----------------------------------------------------------SL DNKDGPVCLQ--VKPCTPEFYQTHFQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -ELEFRSGGDVDHSTLVTLFKLLGYDVHV-LRDQTAQEMQEKLQNFARLPA--HRVTDSC IVALLSHGV-E-------GAIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAGSPGCEE-SDAGKE---------- ----KLPK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALAQVFS-------ERA--CDMHVADMLVKVNALIKDREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >M_musculus_ENSMUSP00000091238 -------------------------------------------------------MENNK TSVDSKS----INNF--------------------------------------------- ------------------------------------------------------------ ---------------------EVKTIHGSKSVDS----GIY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-SSYKMDYPEMGICIIINNKNFH--KST------ -GMSSRSGTDVDAANLRETFMGLKYQVRN-KNDLTREDILELMDSVSKE-D--HSKRSSF VCVILSHGD-E-------GVIYGTNG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGT------------------------- --DEEMAC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCSMLK-------LYA--HKLEFMHILTRVNRKVATEFESF-SLDSTFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >A_carolinensis_ENSACAP00000001629 --------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQ DIFQLLINRNLLSKEDTFIVAELLYRIKCHFLLQK-IGYTQQKVEHNL--FHIRNVSEYR ------------------------------------QMLYEISEGFTEENVKTAMFLLRE HLPK----KQSIAVKLLTSLEKQD-LLAEDKLAILEKICNK-VSPELRNKVDKFKERS-- ------------------------------------------------------------ ---------VFKAFVFSLCYENLYPSNFLAVFLLILQAS--------------------- ------------------------------------------------------------ ---------------------------TCYKMDGLNRGSCLIFNNVHFE----------- GGLSQRRGSQKDAEELESVFRWLGLDVIK-YNDTTSIEMENHLKQWQSFEN--WKDMDCL VCCILSHGE-S-------GKIYGTDGNLIPIRTIMSYFTAKQCPQLAKKPKLFFIQACQG -------------EKT-QQPV---YLET--D-DEYGS----------------------- -FPLQQMI-SSIPEEADFLLGMATVD--GY-------------------------LSFRH VHQGTWYIQALCDKLR-------TLVP-RGEDILSILTEVNADVSRRAD-------AQGQ KKQMPQPAY-----TLRKKLIF-P---IP----------------- >D_rerio_ENSDARP00000083664 ---------------------------------------------------------MLG ECGMTKWERLALRRNSVKMLQDL------------------------------------- ------------------------------------------------------------ -----------VVDDLLIQCLQQDGILTDSMAESIMAKPTS--QGRSHQLLFLLPKRGPR AF----STFCSALKETEQHHLCKLLMD-------FTEKDK------KN------------ -SQYKLSPEICKKKNKHTHTH-------------------------------KSMEM--- ----------------------------------------------------------CL D-ADSPVTTA--VLPCTPEFYQSHRP-QAYPMRSCPRGLALVLSNVRFD-SANT------ -DLDIRRGGEVDEETLRRLFTELDFKVSL-HRDLTAEAMRRCLEQFAQQQE--HAAYDCA VVCLLSHGV-E-------GSVYGTDGQLLELDWVFEVFDNARCPLLQNKPKMFFIQACRG -------------EEM-DNGV----DQL--DGQERTQSPGCEQ-RDAGREGERDNREKKE EKERERLR-VKLPQRSDMICGFATLK--GT-------------------------AAMRN TKKGSWFIQELNTAIR-------QRA--NNTHLSDILVQVNGQIKSREGY--APGSAHHR CKEMSEFTS-----SLCKDLYLFPKYYPSN---------------- >P_pygmaeus_ENSPPYP00000020323 --------------------------------MAAPTAGSWSTFEHKELMAADRGRRILG VCGMHPHHQETLKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQ AF----DAFCEALRETKQGHLEDMLLT-------TLSG--------LQ------------ --HVLPPLSCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEH--- ----------------------------------------------------------SL DNKDGPVCLQ--VKPCTPEFYQTHFQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -ELEFRSGGDVDHSTLVTLFKLLDYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAGSPGCEE-SDAGKE---------- ----KLPK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALAQVFS-------ERA--CDMHVADMLVKVNALIKDREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >G_gallus_ENSGALP00000014503 ------------------------------------------------------------ --------------------KKK------------------------------------- ------------------------------------------------------------ ------------------NGEEEQPKSSLSNQYR----IVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYNMNYKKVGKCIIINNKNFE--DKT------ -GMGTRNGTDKDAGDLSKSFRSLGFDVYT-YNDRSCEDMQTLLKQAAEE-N--HSDAACF ACILLSHGE-E-------GLIYGTDG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRG -------------SEF-DEGI-----QT--D-SGP---AN-DT----------------- LETDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQSLCSVLN-------EHG--KQLEIMQILTRVNYVVATNFESQ-SDDPRFSE KKQIPCVVS-----MLTKELYF------------------------ >H_sapiens_ENSP00000312664 --------------------------------MAAPSAGSWSTFQHKELMAADRGRRILG VCGMHPHHQETLKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQ AF----DAFCEALRETKQGHLEDMLLT-------TLSG--------LQ------------ --HVLPPLSCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEH--- ----------------------------------------------------------SL DNKDGPVCLQ--VKPCTPEFYQTHFQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -ELEFRSGGDVDHSTLVTLFKLLGYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAGSPGCEE-SDAGKE---------- ----KLPK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALAQVFS-------ERA--CDMHVADMLVKVNALIKDREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >P_troglodytes_ENSPTRP00000033921 --------------------------------MAAPSAGSWSTFQHKELMAADRGRRILG VCGMHPHHQETLKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVGS--FSQNVELLNLLPKRGPQ AF----DAFCEALRETKQGHLEDMLLT-------TLSG--------LQ------------ --HVLPPLSCDYDLSLPFPVCESC-----------------PLYKKLRLST-DTVEH--- ----------------------------------------------------------SL DNKDGPVCLQ--VKPCTPEFYQTHFQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -ELEFRSGGDVDHSTLVTLFKLLGYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAGSPGCEE-SDAGKE---------- ----KLPK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALAQVFS-------ERA--CDMHVADMLVKVNALIKDREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >R_norvegicus_ENSRNOP00000014096 -------------------------------------------------------MDNNE TSVDSKS----INNF--------------------------------------------- ------------------------------------------------------------ ---------------------ETKTIHGSKSMDS----GIY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-SSYKMDYPEMGLCIIINNKNFH--KST------ -GMSARNGTDVDAANLRETFMALKYEVRN-KNDLTREEIMELMDSVSKE-D--HSKRSSF VCVILSHGD-E-------GVIFGTNG-PVDLKKLTSFFRGDYCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGT------------------------- --DDDMAC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SRDGSWFIQSLCAMLK-------LYA--HKLEFMHILTRVNRKVATEFESF-SLDATFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >T_guttata_ENSTGUP00000011206 ------------------------------------------------------------ --------------------KKK------------------------------------- ------------------------------------------------------------ ------------------NGEEEQPKPSLSNQYR----IVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYNMDYKKVGKCIIINNKNFE--DKT------ -GMGTRNGTDKDAGDLAKSFKNLGFEVDI-HHDRSRDDMEKLLKKAAEE-N--HSDAACF ACILLSHGE-E-------GLIYGTDG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQACRG -------------SEF-DEGI-----QT--D-SGP---AN-DT----------------- LETDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQSLCSVLN-------EHG--KQLEIMQILTRVNYVVATNFESQ-SDDPRFSE KKQIPCVVS-----MLTKELYF------------------------ >G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MSPRNGTDVDAADAFRTFSKLGYKVTV-ANDQTVDQMIQLLVKVSKQ-D--HSNSASF VCVLLSHGD-E-------GVIYGTDG-FEKLDDLTKFFKGDRCRSLVGKPKLFFIQACRG -------------TEL-DEGS---QIEA--D-S--------------------------- --VGGQTS-DRIPVEADFLYAYSTAP--GY-------------------------YAWRN TQNGSWFMQSLCEMLR-------RFS--GQLELMQIMTRLNHRVALHFESS-SDTPGYSG KKQIPCIVS-----MLTKDFYF-P---K------------------ >T_guttata_ENSTGUP00000017449 ------------------------------------------------------------ ---MEERQRRALRRGRARLVAAL------------------------------------- ------------------------------------------------------------ -----------RVEPLWEPLEQRG-LFTRPMLEELQSA--GSRGEQARQLIIDLETRGKQ AF----PAFLSILRDTGQGHLAEMLMQ--------------------------------E -----CESRPVPP---QLPDLRPVEL---------------------------------- -------------ELQEANQRCAVVL-------------QTAAR--DVAAGIPLTVGK-- SPE-----------------VMSFII-LDYEMKADPCGHCLILNNVNFC--RDS------ -GLSTREGSDIDCEKLERRFKALCFTVLT-RRDLKAQEMVLELLKLSRQ-D--HSALDCC IVVILSHGC-QTSHIQFPGGVYGTDGKPIPIEKIVNYFNGSSCPSLRGKPKLFFIQACGG -------------EQR-DQGF---VVDC--D-SPKEEALGDSL-ESDAIPFRVPSDNV-- --DEPDAI-ASLPTPSDILVSYSTFP--GF-------------------------VSWRE KSSGSWYVETLDSVLE-------QYA--HSEDLLSMLVRVAHAVS-----------ARGR YKQIPGCFN-----FLRKKFFF-VC--R------------------ >A_gambiae_AGAP011952-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ENYDTSHRNRGTALIFNHVNFE----------- -SNAKREGSNKDRDEIKKELLQLGFDARV-FNDLKKQELLAKLDEVAKE-D--HTESDCF VLVMMTHGQ-D-------GSLYAADK-QYQIAELWEPFVGDACKTLIGKPKLFFVQACRG -------------TKF-DKGVKLTKIAT--D-TVDAL----------------------- -SSSSQRT-CVIPTMADVLVMYSAFD--GH-------------------------YSWRN PTHGSWFIQSLSIELN-------QHA--HRKELLQLLTSVSRRVAYLYESNVPGNEQMDG KKQMPCVVS-----MLTKALYF-P---RK----------------- >D_rerio_ENSDARP00000006831 -----------------------------M----------------------------NG DCVDAKRVDTTDASK--------------------------------------------- ------------------------------------------------------------ ------------------DGASAS---QPMQVDA---KPQS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H---A-FRYSLNYPNIGHCIIINNKNFD--RRT------ -GMNPRNGTDVDAGNVMNVFRKLGYIVKV-YNDQTVAQIMQVLTTVAHD-D--HSRCASL VCVLLSHGD-E-------GVFFGTDT-SVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRG -------------TEL-DPGV-----ET--D-HPD------------------------H PDIPD-GR-VRIPVEADFLYAYSTVP--GY-------------------------YSWRN TMTGSWFIQSLCEMMT-------KYG--SELELLQIMTRVNHKVALDFEST-SNMPGFDA KKQIPCIVS-----MLTKEMYF-T---P------------------ >M_musculus_ENSMUSP00000031895 --------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILA VCGMHPDHQETLKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKGGS--FSQNVELLNLLPKRGPQ AF----DAFCEALRETRQGHLEDLLLT-------TLSD--------IQ------------ --HVLPPLSCDYDTSLPFSVCESC-----------------PPHKQLRLST-DATEH--- ----------------------------------------------------------SL DNGDGPPCLL--VKPCTPEFYQAHYQ-LAYRLQSQPRGLALVLSNVHFT--GEK------ -DLEFRSGGDVDHTTLVTLFKLLGYNVHV-LHDQTAQEMQEKLQNFAQLPA--HRVTDSC VVALLSHGV-E-------GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHTQSPGCEE-SDAGKE---------- ----ELMK-MRLPTRSDMICGYACLK--GN-------------------------AAMRN TKRGSWYIEALTQVFS-------ERA--CDMHVADMLVKVNALIKEREGY--APGTEFHR CKEMSEYCS-----TLCQQLYLFPGYPPT----------------- >M_domestica_ENSMODP00000005560 -------------------------------------------------------MEDTG TTVDAKS----IKNS--------------------------------------------- ------------------------------------------------------------ ---------------------GVKSLHSSKSVES----GLS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------S-DSYKMDYPEMGLCVIINNTHFH--NDT------ -ELSPRTGSDKDAANLIDIFRSLKYEVRN-KNNLTRDKMIELLRQVSEE-D--HSQRSSF VCVILSHGE-E-------GVIFGTDD-SVELKELTYFFKGYKCKSLTGKPKLFIIQACQG -------------REF-DCGV-----ET--D-SGT------------------------- --DEDVAC-HKIPVEADFLYAYSTVP--GY-------------------------YSLRD PKDGSWFIQALCAVLK-------QHA--HKLEIMQILTRVNRKVATEFESY-SSKASLHA KKQMPCIMS-----MLTKELYF-S---H------------------ >E_caballus_ENSECAP00000019797 -------------------------------------------------------MENSK ISVDSKS----IKNS--------------------------------------------- ------------------------------------------------------------ ---------------------ETKILHGSKSMDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-SSYKMDYPEMGLCIIINNKNFH--KST------ -GMASRSGTDVDAANLRETFTNLKYEVRN-KNDLTGEEIVALMRSVSKE-D--HSKRSSF ICVLLSHGE-E-------GIIFGTNG-PIDLKKLTCFFKGDCCRSLAGKPKLFIIQACRG -------------TEL-DSGI-----ET--D-SGI------------------------- --EDDMAC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------LYA--HKLELMHILTRVNRKVAMEFESY-CLDPTFHG KKQIPCIVS-----MLTKELYF-Y---H------------------ >D_rerio_ENSDARP00000071815 ---------------------------------------------------MSDVKPKGV DTVDARQSDAK------------------------------------------------- ------------------------------------------------------------ ------------------ESSSVT-DPGLVQMDAKSHSDDN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------V---D-YQYKTNYPNLGQCLIINNKNFH--KRT------ -GMGVRNGTDEDAKKVFETFSQLGFKVGH-YNDLTVSQMMALLNKASQE-D--HSKSAMF ACVLLSHGD-D-------GLIYGTDN-SIELKRLFAHFRGDRCTSLVGKPKLFFIQACRG -------------TDL-DSGI-----EC--D-G--------------------------- --VGDEET-QRIPVEADFLYAYSTAP--GY-------------------------YAWRN VANGSWFISSLCDMLL-------KYG--KQLEIMQVMTRVNHKVALEFESS-SNLPGFDG KKQIPCIVS-----MLTKELYF-P---K------------------ >R_norvegicus_ENSRNOP00000022672 --------------------------------MAASSGRSQSSLHRKGLMAADRRSRILA VCGMHPDHQETLKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKGGS--FSQNVELLNLLPKRGPQ AF----DAFCEALRETRQGHLEDLLLT-------TLSD--------IQ------------ --HILPPLSCDYDSSLPFSVCESC-----------------PPHKQSRLST-DTMEH--- ----------------------------------------------------------SL DNGDGPPCLQ--VKPCTPEFYQAHYQ-LAYRLQSQPRGLALVMSNVHFT--GEK------ -DLEFRSGGDVDHTTLVTLFKLLGYNVHV-LYDQTAQEMQEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAQSPGCEE-SDAGKE---------- ----ELMK-MRLPTRSDMICGYACLK--GN-------------------------AAMRN TKRGSWYIEALTQVFS-------ERA--CDMHVADMLVKVNALIKEREGY--APGTEFHR CKEMSEYCS-----TLCQQLYLFPGYPPT----------------- >D_rerio_ENSDARP00000024255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EQYEMKGERRGVCLIINNYDFS--ACG------ --WLNREGTDIDHDSLRDVFEWLGFEILT-RRDCTGDQILQALMDLSTQ-D--HTQADCV VCCILSHGR-L-------NDIIGVDGKAVPFKELMETLSPFRCSSLYQKPKLFFIQACRG -------------TQN-QRAV---FPQT--F-TED------ED-VLA------------- -SDAGVPR-DSIPEMADYLMAMSTVP--WY-------------------------ASYRD KSKGTWFIQSLCDNLR-------LLVP-RGNDLLSILTKVNADVSKKSD-------KSGL KKQMPQPEF-----SLTRTVVF-P---PPGLP-------------- >T_nigroviridis_ENSTNIP00000001216 ---------------------------------------------------------SAY QLFLSLCDQDHLSEERPHLLSELLSIIQRTRLLRD-LDLRSSATSNL--------ISAY- -------------------------R----------KLLYSLSEDLTDDNLKEIKFLLTE TLPRRKLEDNVTTLEVFLELECMD-LLSKTNLGLLKSILQP-VCPVLAERIRQFEAQN-- ---------------------SCQPAA--------------------------------D -----WGFAVKKITDPLQVQ--------G-------GSDALPSLPEENQSSSRTEASVMS SANAVGIKPGTLMLGLSPPPVGSP-N---------------------------------- --------------------FPVQDL-GTYPMTTLPRGCCLIISNYDFQ--GSG------ --LGMRNGTRTDEECLKKVFEWLGFKVEI-HRDCTGKEILSLMQELADK-S--QQRWDCL VCCILSHGL-E-------GCVHGVDGDQVSIKKLIEPFLGTNCPAMAGKPKLFFIQACQG -------------KKQ-QGVV---HLES--D-GAE------HS-DVD------------- -TDAVRLS-NCIPSHADFLLGMATVP--DY-------------------------VSYRD RERGTWYIQSLCEYLV-------KMVP-RGFDLMSILTKVNEDVSKKND-------NTGD RKQMPQPVF-----TITKRIVF-P---VPSGPAPVLPHFPFVEDSP >G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D---K-YRYKMDYPCMGTCVIINNKTFD--PKT------ -GLSPRNGTDVDAAELEKTFSRLGYKVTV-ANDQTADQMVDLLADVSKQ-D--HRKSASF VCALLSHGD-E-------DGIYGTDG--TSLDDLTKFFKGDRCRSLVGKPKLFFIQACRG -------------TDT-DRGV---NFDA--D-S--------------------------- --TDGQML-QSIPLEADFLYAYSTPS--GY-------------------------YSWRN TQNGSCFMQSLCEILH-------SFS---QLELMQIMTRVNYEVALHFESS-SDKLGYSG KKQIPCIMS-----MLTKDFYF-P---K------------------ >P_troglodytes_ENSPTRP00000054330 -------------------------------------------------------MENTE NSVDSKS----IKNL--------------------------------------------- ------------------------------------------------------------ ---------------------EPKIIHGSQSMDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-NSYKMDYPEMGLCIIINNKNFH--KST------ -GMTSRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVSKE-D--HSKRSSF VCVLLSHGE-E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGV------------------------- --DDDMAC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------QYA--DKLEFMHILTRVNRKVATEFESF-SFDATFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >H_sapiens_ENSP00000311032 -------------------------------------------------------MENTE NSVDSKS----IKNL--------------------------------------------- ------------------------------------------------------------ ---------------------EPKIIHGSESMDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-NSYKMDYPEMGLCIIINNKNFH--KST------ -GMTSRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVSKE-D--HSKRSSF VCVLLSHGE-E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGV------------------------- --DDDMAC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------QYA--DKLEFMHILTRVNRKVATEFESF-SFDATFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------ ------------------STKKK------------------------------------- ------------------------------------------------------------ ------------------KTEDPEKPPQASDNVR----IVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-FQYKMNYGKVGRCIIINNKNFD--DIT------ -GMSPRNGTDIDARDLLRCFKGLGFDVTV-FNNKSCTEMETLLRSVAEQ-D--HKDSACF ACIFLSHGE-E-------GLIYGTDG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQACRG -------------CEF-DDGL-----ET--D-AGP---SN-DS----------------- LETDANPR-HKIPVEADFLYAYSTVP--GY-------------------------YSWRN PGRGSWFVQALCNVLN-------EHG--KELEVMQILTRVNYLVATQFESY-CDDPQFNK KKQIPCVVS-----MLTKELYF-K---PC----------------- >T_nigroviridis_ENSTNIP00000013855 ------------------------------------------------------------ ---MEERHKKILQRNRINLVSEL------------------------------------- ------------------------------------------------------------ -----------EPLNLYDGLIEKG-VFTHDMIDEIKCSG--ARRDQARQLVRDLETRGSR AF----PAFLECLKETGYHSLAELLQN--------------------------------G -----APTVQIQP-PTPIPVDRPVIQPLPISPPLV------------------------- -----------PP-------EEPVSP-------------VPKPSTPGRASPEVEYVTLK- -GR-----------------IRRDSL-QSYRMEANPLGHCLIINNVEFE--PKS------ -GLSNRNGSNVDCDRLERRFKALNFTVKV-KTNLKQRQIRQELSALSKV-D--HSQYDCC VVVILSHGT-EVSHSRFPGAVYGVDGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQACGG -------------DEK-DTGF---QVSP--D-EFEPPVVGADD-QTDAIPVSSSSDSLS- MSDEPDAR-ASLPTSSDILVSYSTFP--GY-------------------------VSWRD PKAGSWYVETLDRVLE-------ENA--ALHDLVVMLTMVNDEVSQNQ--------AKGL YKQMPGSFN-----FLRKRLYF-IA-QP------------------ >P_pygmaeus_ENSPPYP00000017020 -------------------------------------------------------MENTE NSVDSKS----IKNL--------------------------------------------- ------------------------------------------------------------ ---------------------EPKVIHGSKSMDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---D-NSYKMDYPEMGLCIIINNKNFH--KST------ -GMASRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVAKE-D--HSKRSSF VCVLLSHGE-E-------GIIFGTNG-PVDLRKITNFFRGDRCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGV------------------------- --DDDMAC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------QYA--DKLEFMHILTRVNRKVATEFESF-SLDATFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >D_rerio_ENSDARP00000075318 ------------------------------------------------------------ ------MADQLLENLRPDLIKGL------------------------------------- ------------------------------------------------------------ --------SERVINGLLDDLQQKK-VFGEEEIEDIQHRMKT-RADQARHVIDDVKRKGVK ASE--------------------------------------------------------- -----IMLASLKTRDPHLYDTLGIERLLVPVPETELTPSQLSETTGCSTD---------- ------------------------------------------------------------ ---------------------KTNTM-NEYEMKSNPRGLCLIFNNENFK--DPD------ ---MKRHGSQMDTASLKDLFEWLGFSVEI-KQDQTVSAMKRTLKEYSE--D--RKHGDCF VCCVLSHGN-E-------SGVLGSDEKICPVDDITSPFNGANCSSLAGKPKVFFIQACRG -------------HEI-QSKV----MVA--DGSGGSRT---------------------- -QKPGRVS-VSIPKDSDFLIARSTVE--GY-------------------------VSIRD RTSGTWFIQSLCENLK-------EGSK-RGHDILMILTKVNNDVSRKEGSL-KVKNEIVD AKVTPQPIF-----TLRKLLIFRPLKKTGRFS-------------- >G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MDKLYRDV---QSGE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D---K-YRYKMDYPCMGTCVIINIKNFD--LKT------ -GLETRNGTDVDAAELEKTFSKLGYKVTL-VHDQTADQIVDLLRDVSTQ-D--HSNSGSF VCVLLSRGD-E-------GGIYGTDGSFVNLDELTKFVDGNGCRSLVGKPKLLFIQAARG -------------NKL-DDGT---LSEG--D-S--------------------------- --MDGQTP-SRIPVEADFLYAYSTTP--GF-------------------------NAWRD TQNGSWFMQSLCEMLR-------RFS--GQLELMQIMTRVNNKVALEYKTT----PGRSG KRQMPCIVS-----LLTKEFYF-P---------------------- >D_rerio_ENSDARP00000063081 ------------------------------------------------------------ --MSKKESTQRILQHKVFLIDTL------------------------------------- ------------------------------------------------------------ ---------SVEASFILQNVQQAK-LITQRDYNNLSDVSER--ETKIIKLLDKLIGRGEE TC---------------------------------------------------------- -----QEFIDLLRQDCVLENFPVLEGHAIFAS---------------------------- ------------------------------------------------------------ ---------------------SVQKV-SQYKITQNPRGICVIINNVDFT----------- -SMGERRGSDEDQNYLAKVFRWLGFEVVA-HRNKTAAEMKNILQALGRTVD-----GDCF VCCVLSHGV-E-------EGVCGTDGSLVSVDEIRNPFTGVNCQKLVGKPKLFFIQACRG -------------QRK-QLRV---NAQA--D-GPGDGESEMEV----------------- --DGDDFD-ITIPSDTDFLIARSTTD--GH-------------------------VSYRK PDEGSWFIQSLCRNLE-------KHCP-LGADILTILLSVNNEVSIQGL----------H SKQMPVHEV-----AMRMKLILPPVNN------------------- >B_taurus_ENSBTAP00000024166 --------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLR GCGMHPDHQEALKKNRVVLAKEL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMREHIQAKTGS--FGQNVELLNLLPKRGPQ AF----DAFCVALRETKQSHLEELLLR-------TLSG--------LQ------------ --PVVPPLSCDYDLSLPFPVCESC-----------------TRHKRLHLSP-DAVEH--- ----------------------------------------------------------SL DHGDGPPCLQ--VKPCTPEFYQTHHH-LAYRLQSRPRGLALVLSNVHFT--GEK------ -DLEFRSGGDVDHSTLVTLFKLLGYKVHV-LLDQTAQEMQEKLQNFAQLPV--HRVTDSC IVALLSHGV-E-------GGVYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DLQ--DGKNHDRSPKCEE-SDASRE---------- ----ELLK-MRLPTRSDMICGYACLR--GT-------------------------AAMRN TKRGSWYVEALTQVFS-------ERA--CDMHVADMLVKVNALIKEREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >T_nigroviridis_ENSTNIP00000009934 --------------------------------------------------MSANGPASGE DFTDASK---GGEQP--------------------------------------------- ------------------------------------------------------------ ------------------SGSSSS---GKMTVDA---KSAR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Y---S-FRYSLDFPNLGHCIIINNKNFD--RRT------ -GMNTRNGTDVDAANAMKVFSNLGYRVRV-HNDQTVAQISQLLTSAAKE-D--HSRCASF VCILLSHGD-E-------GVLYGTDG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQACRG -------------NDL-DGGI-----ET--D-S--------------------------- --IEDNST-TKIPVEADFLYAFSTAP--GY-------------------------YSWRN TMSGSWFMQSLCDTIS-------KYG--KELELQHILTRVNHKVAVEFESD-SSLPGFNA KKQIPCIVS-----MLTKEMYF-S---------------------- >C_familiaris_ENSCAFP00000005409 --------------------------------MAAASAGRPAALQRKAPTAAGRGRRILG VCGMHPDHQEALKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMREHIQAKVGG--FSQNVELLNLLPKRGPQ AF----DAFCVALRETKQGHLEDLLLT-------TLSG--------LQ------------ --HGLPPLSCDYDLSLTFPMCESC-----------------PPQKQLRLSP-DTVEH--- ----------------------------------------------------------SL DNGDGPPCLQ--VKPCTPEFYQTHYQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -DLEFRSGGDVDHSTLVTLFKLLGYKVHV-LLDQTAQEMKEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GGIYGVDGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHTGSSECEE-SDASKE---------- ----ELLK-TRLPTRSDMICGYACLR--GT-------------------------AAMRN TKRGSWYIEALTQVFS-------ERA--CDTHVADMLVKVNALIKEREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >D_melanogaster_FBpp0084848 ------------------------------------MDATNNGESADQVGIRVGNPEQPN DHTDALGSVGSGGAGSSGLVAGS------------------------------------- ------------------------------------------------------------ --------SHPYGSGAIGQLANGY-SSPSSSYRKNVAKMVT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DRH-A-AEYNMRHKNRGMALIFNHEHFE--VPT------ --LKSRAGTNVDCENLTRVLKQLDFEVTV-YKDCRYKDILRTIEYAASQ-N--HSDSDCI LVAILSHGE-M-------GYIYAKDT-QYKLDNIWSFFTANHCPSLAGKPKLFFIQACQG -------------DRL-DGGV-----TM--Q-RSQ---TETDG----------------- ---DSSMS-YKIPVHADFLIAYSTVP--GF-------------------------YSWRN TTRGSWFMQSLCAELA-------ANG--KRLDILTLLTFVCQRVAVDFESCTPDTPEMHQ QKQIPCITT-----MLTRILRF-S---DKQLAPAGRV--------- >R_norvegicus_ENSRNOP00000022693 -----------------------------------------MTDDQDCAAELEMADSSTE DGVDAKPDRSTIISSLLW-KKKK------------------------------------- ------------------------------------------------------------ ------------------NASM-----CPVSTTR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YLYRMDFEKMGKCIIINNKNFD--KAT------ -GMDVRNGTDKDAEALFKCFRSLGFEVTV-YNDCSCAKMQDLLRRASEE-D--HSNSACF ACVLLSHGE-E-------NLIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGKGSWFVQALCSILN-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPRFNE KKQIPCMVS-----MLTKELYF-G---R------------------ >B_taurus_ENSBTAP00000021099 -------------------------------------------------------MENTE NSVDSKS----IKTS--------------------------------------------- ------------------------------------------------------------ ---------------------ETKILHGSKSMDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---E-ESYKMDYPEMGLCIIINNKNFH--ENT------ -GMCRRSPTDDSVAQXRETFMNLKYEVRI-KNDLTCKEMLELMSNVSKE-D--HSKRSSF ICVLLSHGE-E-------GIIFGTNG-PVNLKKLASFFRGDYCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGA------------------------- --EDDMAC-QKIPVEADFLYAYSTAP--GY-------------------------FSWRN AKNGSWFIQALCEMLK-------KHA--HRLELMHILTRVNRKVAIEYESF-STDSAFHA KKQIPCIMS-----MLTKELYF------------------------ >M_musculus_ENSMUSP00000030747 ------------------------------------------------------------ ---MDEADRQLLRRCRVRLVSEL------------------------------------- ------------------------------------------------------------ -----------QVAELWDALLSRE-LFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQ AL----PLFISCLEDTGQGTLASLLQS--------------------------------G -----RQAAKQDP---E--AVKPLDHLVPVVLGPMGLTAKEQRV--------VKLDPSQP AVGNLTPVVLGPEELWPARLKPEVLR-------------PETPRPVDIGSGGAHDVCV-- PGK-----------------IRGHAD-MAYTLDSDPCGHCLIINNVNFC--PSS------ -GLGTRTGSNLDRDKLEHRFRWLRFMVEV-KNDLTAKKMVTALMEMAHR-N--HRALDCF VVVILSHGC-QASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAC--T-SSQGRTLDSDS-EPDAVPYQEGPRPL-- --DQLDAV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRD KKSGSWYIETLDGILE-------QWA--RSEDLQSLLLRVANAVS-----------AKGT YKQIPGCFN-----FLRKKLFF-KT--S------------------ >B_taurus_ENSBTAP00000008706 ------------------------------------------------------------ -----------------S-KKKK------------------------------------- ------------------------------------------------------------ ------------------NDSG-----KSVNIPR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKVGKCIIINNKNFD--RIT------ -GMGVRNGTDKDAEALFKCFRSLGFDVSV-YNDCSCAKMQDLLKKASEE-D--HRNSACF ACILLSHGE-E-------NLIYGTDG-KTAIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGSGSWFVQALCSILN-------EHG--KSLEILQILTRVNDRVARHFESQ-SDDPRFHE KKQIPCVVS-----MLTKELYF------------------------ >E_caballus_ENSECAP00000003321 --------------------------------MAAPSAPSLPALQQKGLMAADRGRRILG VCGMHPDHQEALKKNRVVLAKQL------------------------------------- ------------------------------------------------------------ -----------LLSELLEHLLEKD-IITLEMRELIQAKVTS--FGQNVELLNLLPKRGPQ AF----EAFCVALRETKQGHLEDLLLT-------TLSG--------LQ------------ --HVLPPLSCDYDLSLPFPVCESC-----------------PPHKQLRLST-DTVEH--- ----------------------------------------------------------SL DNGDGPPCLQ--VKPCTPEFYQAHYQ-LAYRLQSRPRGLALVLSNVHFT--GEK------ -DLEFRSGGDVDHSTLVTLFKLLGYNVHV-LLDQTAKEMQEKLQNFAQLPA--HRVTDSC IVALLSHGV-E-------GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRG -------------DET-DRGV----DQQ--DGKNHAKSPECEE-SDAGKE---------- ----ELLK-MRLPTRSDMICGYACLK--GT-------------------------AAMRN TKRGSWYIEALTQVFS-------ERA--CDMHVADMLVKVNALIKEREGY--APGTEFHR CKEMSEYCS-----TLCRHLYLFPGHPPT----------------- >C_familiaris_ENSCAFP00000032189 ---------------------------MGEQRNTSSKELAAAEATGQSGKELEVSMENTE NSVDAKS----FKNA--------------------------------------------- ------------------------------------------------------------ ---------------------ETVIV---KILKD----KYL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------T---K-LHYKMDYPEMGLCIIINNKNFH--KST------ -GMAPRSGTDVDAANLRETFTNLKYEVRN-KNDLTCEEILELMNSVSKE-D--HSKRSSF VCVLLSHGD-E-------GIIFGTNG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGI------------------------- --EDDMAC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------LYA--HKLEFMHILTRVNRKVATEFESF-SLDSAFHG KKQIPCIVS-----MLTKELYL-Y---H------------------ >B_taurus_ENSBTAP00000003205 ------------------------------------------------------------ ---MNEADRLLLRRYRVRLVGEL------------------------------------- ------------------------------------------------------------ -----------QVASLWDALLSRE-LFTPDMIEDIQRAGSGSRRDQARQLILDLETRGSQ AL----PLFISCLEDTGQDTLASLLKT--------------------------------S -----RQAAKQ----------------------------------------------SKP SQGKLAPVVLGPEELWPAKLRPEVLR-------------PEVPRAVDAGSGGFTDVCP-- QDR-----------------AKGNAD-LAYVLNADPCGHCLIINNVNFC--RES------ -GLRARTGSNIDCERMRQRFHLLQFVVEV-KCDLTAKQMVQALMQLARQ-D--HSALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSVERIVNTFNGTGCPSLRGKPKLFFIQACGG -------------EQK-DHGF---EVES--T-SPEDKTPSSDP-EADATPFQEGPRSI-- --DEPDAV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRD PKSGSWYIETLDSIFE-------QWA--HCEDLQTLLLRVANAVS-----------VKGI YKQMPGCFN-----FLRKKLFF-KT--------------------- >C_intestinalis_ENSCINP00000007986 ------------------------------------------------------------ ---MLSTHKEKLRTNRHTLCKEL------------------------------------- ------------------------------------------------------------ -----------VVDELLQELIGEG-IFNDILADRVLSHQRD--FKKNVEFLTLLPGRGPN AF----NAFRIALINSDQSHLAELLDPAQGVSQPNESNANDGSGGPELSASIFRFESIAT ANSNLPGTSGTSAPLSRRRPMENTDQSSTSIASSQVIYANQGTPPKRNRESSSYIEQMDD APSPTDSLSNIRSTASVHSLFSRSDVRTQSNTAINHINTVQSPTSTKAATSYQINLHQGM DLFDGPTVSDLTVRKSTHQHLMQHTDCYQMTMRGRPKGAALIISVEKFH--PES------ -DLLNREGSEKDRVRLELVLQQIGFQCYV-LINGTAEQIVSTLQTFAELEE--HYDNSCS LVAAMSHGD-A-------GCFYGSDGVSVAIDTVVNFFSNQNCHSLQKKPKIFLFQACQG -------------DEY-DMGV----DEV--DGPVQAPVGDVDNTSTS------------- -SSNDHIR-NKLPQKSDMLIGQATMK--GF-------------------------AAMRN TKHGSWYIQAFVRVLA-------RHA--CDTDLLDMMTKVNNILKHKEGW--CPGSVYHR CKVMPEFKS-----SLSKKLYFFPGI-------------------- >E_caballus_ENSECAP00000015102 ------------------------------------------------------------ ---MNEADRQLLRRSRLRLVREL------------------------------------- ------------------------------------------------------------ -----------QVDSLWDALLTRE-LFTPDMIEDIQR--SGSRRDQARQLIIDLETRGSQ AL----LLFISCLEDTGQDTLASFLRT--------------------------------S -----SQAAKQNP---E--AIRPSD-LPPVVLGPVGLKPEELTA--------VKQDPSKL TPGKLTPVVLGPEELWLAKLRPEVLR-------------PEVPRPVDIGSGGFSDVRA-- QDR-----------------LRGNAD-LAYVLNADPCGHCLIINNVNFY--LAS------ -GLGRRVGSDIDCEKLRQRFSLLHFMVEV-KGDLTAKQMLRALGELARR-D--HGALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSIESIVNIFNGTGCPSLGGKPKLFFIQACGG -------------EQK-DPGC---KVDS--T-SPEDRTPGSDS-EPDAVPFQEGPGTF-- --DQPDAV-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRD PKSGSWYVETLDGVFE-------QWA--HSEDLQTLLLRVAHAVS-----------EKGV YKQIPGCFN-----FLRKKFFF-KT--Y------------------ >C_intestinalis_ENSCINP00000003204 -----------------------------MSLK----SAADVLMSGVPTPHTNENNNVGQ SEVDAL------------------------------------------------------ ------------------------------------------------------------ --------------------GSGE-TPRIYSLPDVTKMASS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E---V-ECYQMDRESRGLALIINNENFH--HAT------ -RMNKRSGTDVDARNLSRIFKKLGFDVQV-YKDLSCISMLEVINEVSTM-D--HTGNDCC FVAFLSHGD-D-------GCVYGTDG-IVQIKKIVDQFRGDVCPSLAGKPKIFLFQACRG -------------TLH-ETSV---QLSV--D-VVDGE----DQ-PCV------------- -EVDAAPV-PTLPSGSDYLFCYSVAE--GY-------------------------YSHRD TLYGSWFIQDFTDVMEQLVLNKGKQQ--DKVDFIDVLTVVNRKVSARRVER-SYSQQALG KKQMPCYLS-----MLTKKLYL-T---PKK---------------- >D_rerio_ENSDARP00000047019 ------------------------------------------------------------ ---MEQKHRQILQRHRLNLVKAL------------------------------------- ------------------------------------------------------------ -----------NPEDVCDKLLSKG-VFTQDMIDEIQSKA--TRRDQARQLVKDLETRGSL AF----PAFLDSLRETGHNDLAELLQS--------------------------------G DGVHRPPVISVQPSPIPLP-----VQNLNH-----TEKPDKPDI-----------ASP-- ---------RLVPL------RPESLP-------------VHK-----TYSPPSETVVR-- PTR-----------------PRRDSI-QCYKMDASPCGVCLIINNINFE--KAS------ -ELNDRKGSNIDCDKLEKRFKALNFEVTV-KRNLKSKRIRHEMASLAKK-D--HSTYDCC VVIILSHGT-EASHNRFPGAVHGVDGPAVPIQIITNYLNGQNCPSLQGKPKLFFIQACGG -------------GEK-DIGF---EVSP--D-DVQPSIGGIDD-EMDAIPMSSSSDSLST ASDELDAR-ASLPTPSDILVSYSTFP--GY-------------------------VSWRD TEAGSWYVENLDRVLE-------ENA--ITDDLVTMLMLVNDAVSQIS--------AKGL YKQMPGSFN-----FLRKLLYF-QSSQS------------------ >T_nigroviridis_ENSTNIP00000022078 ---MA-----------------------------------GEAAGIPELGGEAEGEHRCE DDVDAKPDRRGRFLLFKS-KKKN------------------------------------- ------------------------------------------------------------ ------------------DGQMREQDYCSESHYR----IVS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYRMSHQRVGKCIIINNKNFD--EKT------ -GMNVRNGTDRDAGELYKCFKSLGFDVFI-YNDQTCEKMEHLLREASEE-D--HSDSSCF ACILLSHGE-E-------GMIYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG -------------SEF-DDGI-----QT--D-SGP---PN-DT----------------- METDANPR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQALCNVLN-------EFG--KQLEIMQILTRVNYMVATSFESW-SEDPRFSE KKQIPCVVS-----MLTKELYF-K---PC----------------- >M_mulatta_ENSMMUP00000015808 -------------------------------------------------------MENTE NSVDSKS----IKSL--------------------------------------------- ------------------------------------------------------------ ---------------------EPKIIHGSKSVDS----GIS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------L---E-NSYKMDYPEMGLCIIINNKNFH--KST------ -GMASRSGTDVDAANLRETFINLKYEVRN-KNDLTREEIVELMRNVSKE-D--HSKRSSF VCVLLSHGE-E-------GIIFGTNG-PLDLKKITSFFRGDCCRSLTGKPKLFIIQACRG -------------TEL-DCGI-----ET--D-SGV------------------------- --EDDMAC-HKIPVEADFLYAYSTAP--GY-------------------------YSWRN SKDGSWFIQSLCAMLK-------QYA--DKLEFMHILTRVNRKVATEFESF-SLDATFHA KKQIPCIVS-----MLTKELYF-Y---H------------------ >G_aculeatus_ENSGACP00000008661 ------------------------------------QVNGARLTSAQDVA--AEEGGPTG DQTDAKPDRRGRFLLFGNIKKNK------------------------------------- ------------------------------------------------------------ ------------------DGQTREQDYSSESHYR----VVS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYKMSHQRVGKCIIINNKNFD--EKT------ -GMNVRNGTDRDAGELFKCFKSLGFDVFI-YNDQTCGKMESLLREASEE-D--HSDSSCF ACILLSHGE-E-------GMIYGTDA-AMPIKSMTSLFRGDMCKSLVGKPKLFFIQACRG -------------SEF-DDGI-----QT--D-SGP---PN-DT----------------- LETDANPR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQALCNVLN-------EFG--KQLEIMQILTRVNYMVATSFESW-SEDPRFSE KKQIPCVVS-----MLTKELYF-N---------------------- >G_aculeatus_ENSGACP00000022402 -----------------------------MSVNGP-----------------------GE DRTDAKT----EQSE--------------------------------------------- ------------------------------------------------------------ ------------------VSSSAS---APEEVDA---KPNV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H---S-FRYSLSFPSIGQCIIINNKNFD--RGT------ -GMNQRNGTDVDAANAMKVFGNLGYKVKV-YNDQSVAQIQHVLTSVSKQ-D--HSCSASF VCVLLSHGD-G-------DLFFGTDG-PVPLKSLTSLYRGDRCKSLVGKPKLFFIQACRG -------------TEL-DPGI-----EA--D-S--------------------------- --VKD-ET-TRIPVEADFLYAFSTAP--GY-------------------------YSWRN TTTGSWFMQSLCDMIS-------KYG--KELELQHIMVRVNHKVAVAFESV-SNSPDFNA RKQIPCVVS-----MLTKEMYF-S---P------------------ >G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------ -CGMQERDRLALRTRSTVLCKQL------------------------------------- ------------------------------------------------------------ -----------VVDELLIQSLQTDEILTEAMAENIMAEQTS--QKRSWRLLLLLPKRGPR AF----SSFCSALQETEQQHLYELLIQ-------SSEKDG------KE------------ -TPGMLMCGQFIDSSLPLPTQEVV-----------------AAK-RARTQA-ESMEF--- ----------------------------------------------------------SL D-ADSPINSP--VLPCTPDFYLSHCH-QSYRMNSSPRGFALVISNVTFDPCAAP------ -DLDPRKGGEVDDEVLRKVFTELDYVVKV-HRDLTAQDMRTCIEEFSRRPD--HRTMASC VVCLLSHGV-E-------GAIYGTDGQLLKLDWVFESFDNAHCPLLQNKPKMFFIQACRG -------------EEM-DCGV----EQI--DGPVRTCSPSCEQ-RDAGREGQGD-ASARQ RGDMG--R-IKLPQRSDMICGFASLK--GT-------------------------AAMRN TKRGSWFVQELNKRLR-------LHA--RDTHLADIMVQVNRHIKEREGY--APGTAHHR CKEMSEFTS-----SLCKDLYLFPKYQPQ----------------- >P_pygmaeus_ENSPPYP00000003106 --------MDCVGWPPGRRWHLEKNTSCSGSSGICASYVTQMADDQGCVEEQGLGDSANE DSVDAKPDRSSFVPFLFS-MKKK------------------------------------- ------------------------------------------------------------ ------------------NVSM-----QSIKTTR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKLGKCIIINNKNFD--KVT------ -GMGVRNGTDKDAEALFKCFRSLGFDVIV-YNDCSCAKMQDLLKKASEE-D--HTNAACF ACILLSHGE-E-------NLIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGRGSWFVQALCSILE-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPRFHE KKQIPCVVS-----MLTKELYF-S---Q------------------ >T_rubripes_ENSTRUP00000040691 ------------------------------------------------TNMSANGPSPGG DFTDAKK--GAGQQP--------------------------------------------- ------------------------------------------------------------ ------------------RSGSSS---GRVTVDA---KPAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Y---S-FRYSLDFPNMGHCIIINNKNFD--RRT------ -GMNTRNGTDVDAANAMKVFLSLGYKVKV-HNDQTVNQMKQLLVSAAEE-D--HSACASF VCVLLSHGD-E-------GVFFGTDG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQACRG -------------NDL-DGGI-----ET--D-S--------------------------- --AADSST-TKIPVEADFLYAFSTAP--GY-------------------------YSWRN TTSGSWFMQSLCDAIS-------KYG--KELELQHILTRVNHKVAVDFESV-SNLPGFDA KKQIPCIVS-----MLTKEMYF-S---------------------- >C_elegans_C48D1.2 ------------------------------------------------------------ --MMRQDRRSLLERNIMMFSSHL------------------------------------- ------------------------------------------------------------ -----------KVDEILEVLIAKQ-VLNSDNGDMINSCGTV--REKRREIVKAVQRRGDV AF----DAFYDALRSTGHEGLAEVLEP--------------------------------L ARSVDSNAVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSYQDIYSRARS RSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYI FHEEDMNFVDAPTISR-----VFDEK-TMYRNFSSPRGMCLIINNEHFE----------- -QMPTRNGTKADKDNLTNLFRCMGYTVIC-KDNLTGRGMLLTIRDFAKH----ESHGDSA ILVILSHGE-E-------NVIIGVDDIPISTHEIYDLLNAANAPRLANKPKIVFVQACRG -------------ERR-DNGF---PVL---D-SVDGVPAFLRR-GWDNRDGPLFNFLGCV RPQVQQVW-RKKPSQADILIAYATTA--QY-------------------------VSWRN SARGSWFIQAVCEVFS-------THA--KDMDVVELLTEVNKKVACGFQTS----QGSNI LKQMPEMTS-----RLLKKFYF-W---PEARNSAV----------- >G_gallus_ENSGALP00000017288 -----------------------------------------------MMTDIKDGPRSGE DVSDARS----FPGS--------------------------------------------- ------------------------------------------------------------ ---------------------KGMNLPASKSVDS----GIL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---D-DSYRMDYPEIGVCVIINNKNFH--RDT------ -GLSSRSGTDADAASVREVFMKLGYKVKL-NNDLSSRDIFKLLKNVSEE-D--HSKRSSF VCVLLSHGD-E-------GLFYGTDG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQACRG -------------TEL-DSGI-----EA--D-SGP------------------------- ---DETVC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN AAEGSWFIQSLCRMLK-------EHA--RKLELMQILTRVNRRVA-EYESC-STRQDFNA KKQIPCIVS-----MLTKEFYF-P---C------------------ >A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------ -----FR----------------------------------------------------- ------------------------------------------------------------ -----------------------------------RNHLFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-AEYKMSHKRRGLALIFNHEHFF--WHL------ -MLPERRGTQADKENLKRGLTDLGFEVKC-FDDLKAEEVLQNIYNVSTD-E--HDDADCF LCVFLSHGE-D-------DHVYAYDA-KIEIKSLTNMFKGDKCPSLVGKPKIFVIQACRG -------------DKH-DDPV----IAR--D-TVDSK-KELDI-NET------------- -EVDTAAV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TINGSWYIQDLCEMLK-------RHG--SSLEFTDLLTLVNRKVSHREVDV-CKDRKALG KKQIPCFAS-----MLTKKLYF-R---PKFK--------------- >G_gallus_ENSGALP00000002083 ------------------------------------------------------------ ---MEEAQRSALRRGRVRLVEGL------------------------------------- ------------------------------------------------------------ -----------RPEVLWGPLQARG-VFTSAMVEDMQST--GTRREQARQLVIDLETRGKQ AF----PIFLSILRDTGHGDLADMLDE--------------------------------G -----CGSPMSPP-----VDLRPVQLELPGERRDK------------------------- ----------------------------------------------SVSTAERLSIPV-- QPESERFRMPPAPAQACPTGLAGECS-EVYQLRADPCGHCLIFNNVSFS--RDS------ -DLSTRAGSDIDCEKLEKRFRSLCFHVRT-LRNLKAQEIDVELRKLARL-D--HSALDCC LVVILSHGC-QTSHIQFPGGIYGTDGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQACGG -------------EQK-DQGF---EVDC--E-SPQDETCRRSI-ESDAIPFQAPSGNE-- --DEPDAV-ASLPTPGDILVSYSTFP--GF-------------------------VSWRD KVSGSWYVETLDSVLE-------HYA--RSEDLLTMLLRVSDIVS-----------TKGR YKQIPGCFN-----FLRKKFFF-LC--K------------------ >G_aculeatus_ENSGACP00000016983 ------------------------------------------------------------ -----MSARGKVRSQKTAIHEAL------------------------------------- ------------------------------------------------------------ ---------CADYSLILNKVFEKG-LITPREYRNLKSINKESVEGHVIELVDKLLDKGED TCE--------------------------------------------------------- -----AFLSLLQTDDDIVKTYPALRTLQLDDRGTLHAPVQDTSVGHSDVRPPPSK----- ------------------------------------------------------------ ---------------------KLKKD-ERYELNSQPSGLCVIINNKNFS----------- ---KPRRGSDKDAESLGEVFTWLGFRALM-CKDQTKDQMERALNKFTALQEA-PRHGDAL ICCILSHGR-K-------GVVLGIDDQPLSIKQIIGTFLPPANTTLTGKPKVFLIQACQG -------------GQA-QHGV-FEELQA--D----------------------------- ----DSPS-PTIPKEADVLVAVATVE--DY-------------------------LAFRH ITDGSWFIQSVCEQLK-------DGCP-RGEDITTILQRVNWEVGKKEGCS-----APGA GKQMPEVRF-----TLRKKLVL-S---PHPNCFVAK---------- >G_gorilla_ENSGGOP00000007184 -----------------------------------------MADDQGCVXXXXXXXXXXX XXXXXXXXXXXXXXXXXX-XXXX------------------------------------- ------------------------------------------------------------ ------------------XXXX-----XXXXXXX----XXX------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------X---X-XXXXXXXXXXXXXXXXXXXXFD--KVT------ -GMGVRNGTDKDAEALFKCFRSLGFDVIV-YNDCSCAKMQDLLKKASEE-D--HTNAACF ACILLSHGE-E-------NVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGRGSWFVQALCSILE-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPRFHE KKQIPCVVS-----MLTKELYF-S---Q------------------ >T_rubripes_ENSTRUP00000031759 SMQMA-----------------------------------GEPTEISDLGGEVEEGGQSE DDVDAKPDRKGRFLLFKS-KKNK------------------------------------- ------------------------------------------------------------ ------------------DGQMREQDYCSESHYR----IVS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYKMSHQRVGKCIIINNKNFD--EKT------ -GMNVRNGTDRDAGELFKCFKTLGFDVFI-YNDQTCEKMERLLREASEE-D--HSDSSCF ACILLSHGE-E-------GMIYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG -------------SEF-DDGI-----QT--D-SGP---PN-DT----------------- METDANPR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQALCNVLS-------EFG--KQLEIMQILTRVNYMVATSFESW-SEDPRFSE KKQIPCVVS-----MLTKELYF-K---QC----------------- >O_anatinus_ENSOANP00000002508 -----------------------------------------MADDQAPTMHQKECD--FE DEVDAKPERLK-VAQLFS-KKKN------------------------------------- ------------------------------------------------------------ ------------------EAESQSGG-PLPVRNR----VVS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S---S-FIYNMKYENLGKCIIINNKNFA--SKT------ -GMSTRNGTDKDAGNLQKCFRSLGFDVSV-FNDFSCNQMKEILQKASEE-N--HENSACF ACILLSHGE-G-------DCIYGTDD-FIPIKELTILFRGDKCKSLLGKPKLFFIQSCRG -------------TEF-DDGI-----QT--D-STP---VT-D------------------ --SDANPG-CRIPVEADFLFAYSTVPVKGY-------------------------YSWRN VDRGSWFVQALCSVLH-------EHG--KELEIMQLLTRVNHQVAINFESQ-ASDPRYCQ KKQIPCLVS-----MLTKELYF------------------------ >X_tropicalis_ENSXETP00000003217 ------------------------------------------------MEESHNGVQYGE DTADAKT------------YFTN------------------------------------- ------------------------------------------------------------ ------------------QQISLQ---NCDIKDMEKKTKFA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H---L-HKYRTDYPEMGICLIINNKNFQ--SST------ -NMGVRNGTDVDARKLHETFTGLGYKVKV-CNDQKSNDIFTLLKKMSEE-D--HSKRSSF VCAILSHGE-D-------GLVYGVDG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQACRG -------------TDL-DSGI-----ET--D-SGS---EP-G------------------ -----EEI-QRIPVEADFLYAYSTVP--GY-------------------------YSWRN TMNGSWFIQSLCEMIK-------LYG--PHLELIQILTCVNHMVALEFESC-STQQAFHA KKQIPCVVS-----MLTKAFYF-L---K------------------ >P_troglodytes_ENSPTRP00000005216 --------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANE DSVDAKPDRSSFVPSLFS-KKKK------------------------------------- ------------------------------------------------------------ ------------------NVTM-----RSIKTTR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKLGKCIIINNKNFD--KVT------ -GMGVRNGTDKDAEALFKCFRSLGFDVIV-YNDCSCAKMQDLLKKASEE-D--HTNAACF ACILLSHGE-E-------NVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGRGSWFVQALCSILE-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPRFHE KKQIPCVVS-----MLTKELYF-S---Q------------------ >E_caballus_ENSECAP00000013731 -----------------------------------------MADDQDCVVEQGAGDSTST DAVDAKPDRSSFVPSLFS-KKKK------------------------------------- ------------------------------------------------------------ ------------------NGPE-----RSITTNR----NRE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKVGKCVIINNKNFD--RGT------ -GMGVRNGTDKDAEALFKCFRNLGFDVVV-YNDCSCAKMKSLLKQASEE-D--HRNSACF ACILLSHGE-E-------NLIYGTDG-MTPIKDLTGHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---INDD------------------ --TDANPR-YKVPVEADFLFAYSTVP--GY-------------------------YSWRN PGSGSWFVQALCSILN-------EHG--KSLEIIQILTRVNHRVARHFESH-SDDPRFHQ KKQIPCVVS-----MLTKELYF------------------------ >M_domestica_ENSMODP00000004412 ------------------------------------------------------------ ---MEESQRELFQKNRLRLVCEL------------------------------------- ------------------------------------------------------------ -----------QVEPLWDLMLDRE-LFTRDMIEDIQRA--GTRRDQARQLVTDLQTRGKR AL----PIFISCLEATGQWDLAALLSE--------------------------------S -----NTTLTQQP---DPIDIKPVEMIRSGGLRSTGRYTSMVSLH-------LLLLANSP FLYFIDAVLVSAHNLFPLELIKRQ---------------PTFSKVLSLLYKLRFPFCP-- ---------------------PPQVG-QVYTLNSDPCGYCLIINNVDFC--ASS------ -GLSSRKGSNIDCEKMHNRFQALHFAVEV-ERNLSAKGMGAALQQLAER-D--HSALDCC VVVILSHGC-QASHIQFPGAIHGTDGASISVERIVNIFSGSRCPSLGGKPKLFFIQACGG -------------DQR-DHGF---QVSS--N-IPEDKSPGSDP-ETDATPFQNN------ -FDQPDAV-ASLPTPSDILVSYSTFP--GF-------------------------VSWRD PKSGSWYIETLDRVLE-------EWA--DREDLLHMLLMVSNAVS-----------ARGT YKQIPGCFN-----FLRKRFFF-KT--K------------------ >O_cuniculus_ENSOCUP00000009498 -----------------------------------------MADDQAHAGELGAGDSESA DAVDAKPDRSSFVPALFS-KKKK------------------------------------- ------------------------------------------------------------ ------------------NGPK-----QSAKATR----DQV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---S-YQYNMNFDKMGKCIIINNKNFD--KVT------ -GMGVRNGTDKDAEALFKCFRSLGFDVMV-YNDCSCARMQDLLKRASEE-D--HTNSACF ACILLSHGE-E-------NLIYGKDG-VIPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-HKIPVEADFLFAYSTVP--GY-------------------------YSWKN PGRGSWFVQALCSILD-------EHG--KELEVMQILTRVNDRVARHFESQ-SDDPRFNE KKQIPCVVS-----MLTKELYF-C---R------------------ >H_sapiens_ENSP00000365051 ----------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSW LLAMDEADRRLLRRCRLRLVEEL------------------------------------- ------------------------------------------------------------ -----------QVDQLWDALLSRE-LFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQ AL----PLFISCLEDTGQDMLASFLRT--------------------------------N -----RQAAKL----------------------------------------------SKP TLENLTPVVL-----RPEIRKPEVLR-------------PETPRPVDIGSGGFGDVGA-- LES-----------------LRGNAD-LAYILSMEPCGHCLIINNVNFC--RES------ -GLRTRTGSNIDCEKLRRRFSSLHFMVEV-KGDLTAKKMVLALLELAQQ-D--HGALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAS--T-SPEDESPGSNP-EPDATPFQEGLRTF-- --DQLDAI-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRD PKSGSWYVETLDDIFE-------QWA--HSEDLQSLLLRVSAAFL-----------CKGE GRLLRGSVSSWGWGFGVSRAGP-NQ--G------------------ >A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------IPVSKSVDS----VIE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------A---D-ESYRMDHPEMGLCILVNNKNFH--PAT------ -GMSYRSGTDRDAAHVVDTFRTLGYMVKP-YNDLTCKQIVDVLHNVSKD-D--HHKRNSF VCVLLSHGE-D-------GLIYGTDG-HVELKMLTSFFRGDKCKSLAGKPKLFFIQACRG -------------TEL-DSGI-----ET--D-SAS------------------------- ---DESMC-QKIPVEADYLYAYSTAP--GY-------------------------YSWRN SSDGSWFIQSLCSMLK-------QYS--HKLELMQILTRVNRKVT-EFTSC-SNHPDFHG KKQIPCIMS-----MLTKDFYF-P---H------------------ >T_guttata_ENSTGUP00000014729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------F ACILLNHGE-E-------GLIYGTDG-PMAIKSLTALFRGDKCKSLIGKPKLFFIQACRG -------------SEF-DEGI-----QT--D-SGP---AN-DT----------------- LETDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQSLCSVLN-------EHG--KQLEIMQILTRVNYVVATNFESQ-SDDPRFSE KKQIPCVVS-----MLTKELYF------------------------ >O_latipes_ENSORLP00000010095 -----------------------------MASNRP-----------------------GE DSTDARK----DNGE--------------------------------------------- ------------------------------------------------------------ ------------------LAAGASPAPDRMDVDG---KPSS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H---S-FRYSLNFPTIGLCIIINNKNFD--RGT------ -GMNQRNGTDIDAASAMKVFSKLGYRVKI-YNDQTVKQIKQLLTDVSRM-D--HSDSASF VCILLSHGD-E-------GVFFGTDG-SIELKTLTSLFRGDHCKSLVGKPKLFFIQACRG -------------TEL-DDGI-----EA--D-S--------------------------- ---KE-DT-TKIPVEADFLYAFSTAP--GY-------------------------YSWRN TMTGSWFINSLCEMLS-------KYG--KELELLHIMTRVNHMVAVEFESI-STLPGFHA KKQIPCIVS-----MLTKEMYF-Y---P------------------ >M_musculus_ENSMUSP00000026062 -----------------------------------------MTDDQDCAAELEKVDSSSE DGVDAKPDRSSIISSILL-KKKR------------------------------------- ------------------------------------------------------------ ------------------NASA-----GPVRTGR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YLYRMDFQKMGKCIIINNKNFD--KAT------ -GMDVRNGTDKDAGALFKCFQNLGFEVTV-HNDCSCAKMQDLLRKASEE-D--HSNSACF ACVLLSHGE-E-------DLIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --IDANPR-NKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGKGSWFVQALCSILN-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPRFNE KKQIPCMVS-----MLTKELYF-S---R------------------ >D_rerio_ENSDARP00000019984 MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAMCRVDKEALTSEIEVLEEDQDSYGEE DVTDAKPDRKGRFRLFGN-FKKN------------------------------------- ------------------------------------------------------------ ------------------DGKLQEKG-ESESHYR----IVS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-FQYKMSHQRVGKCIIINNKNFD--EKT------ -GMNVRNGTDRDAGELFKCFKSLGFDVAV-YNDQTCRNMERLLKAVSEE-D--HSDSSCF ACILLSHGE-E-------GMIYGTDG-AMPIKTMTSLFKGDVCKSLVGKPKLFFIQACRG -------------SEF-DDGV-----QT--D-SGP---PN-DT----------------- IETDANPR-HKIPVEADFLFAYSTVP--GY-------------------------YSWRN PGRGSWFVQALCNVLS-------EFG--KQLEIMQILTRVNYMVATSFESW-SEDPRFSE KKQIPCVVS-----MLTKELYF-N---------------------- >R_norvegicus_ENSRNOP00000017972 ------------------------------------------------------------ ---MEEADRQLLRRCRVRLVREL------------------------------------- ------------------------------------------------------------ -----------QVAELWDALLSRE-LFTRDMIEDIQRAGSGSRRDQARQLVIDLETRGRQ AL----PRFISCLEDTGQGSLASFLQS--------------------------------S -----GQAAKQDP---E--AVTPLDHLVPVVLGPMGLKSKEQKV--------VKLDPSQP ALGNLTPVVLGPEELWPTRLRPEVLT-------------PETPRPVDIGSGRAHDVCT-- PGK-----------------IERHAD-MAYTLDSDPCGHCLIINNVNFC--PSS------ -GLSTRIGSHVDCEKLQHRFCWLRFMVEV-KNDLTAKKMVTALMEMAHR-D--HRALDCF VVVILSHGC-QASHLQFPGAVYGTDGCSVSIERIVNIFNGTGCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAF--T-SSQDKAFDSDS-EPDAVPYQEGPRTL-- --DQLDAV-SSLPTPSDILVSYSTFP--GF-------------------------VSWRD KKSGSWYIETLDGVLE-------QWA--RSEDLQSLLLRVANAVS-----------EKGV YKQIPGCFN-----FLRKKLFF-KL--H------------------ >P_pygmaeus_ENSPPYP00000002138 ------------------------------------------------------------ ---MDEADRRLLWRCRLRLVEEL------------------------------------- ------------------------------------------------------------ -----------QVDQLWDALLSRE-LFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQ AL----PLFISCLEDTGQDMLASFLRT--------------------------------N -----RQAAKL----------------------------------------------SKP TLENLTPVVLRPEIVRPEIRKPEVLR-------------PETPRPVDIGSGGFGDVGA-- LES-----------------MRGNAD-LAYILSMDPCGHCLIINNVNFC--RES------ -GLRTRTGSNIDSEKLRRRFSSLHFMVEV-KGDLTAKEMVLALLELAQQ-D--HGALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAS--T-SPEDESPGSNP-EPDATPFQEGLRTF-- --DQLDAI-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRD PKSGSWYVETLDDIFE-------QWA--HSEDLQSLLLRVANAVS-----------VKGI YKQMPGCFN-----FLRKKLFF-KT--S------------------ >O_latipes_ENSORLP00000010793 ---------------------------MDMAETAE--------------------ELSGK DQVDTKP----VISK--------------------------------------------- ------------------------------------------------------------ ------------------RSPANQ--PNPRSTDVCVIKQDA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D---P-YRYSMDYPKMGICLIINNKNFH--KDS------ -GMGPRNGTDNDAAAAWKSFMKLGYEIQM-YNDQTVDQMKKLFRQMSNQ-D--HSKFASF ACVILSHGE-E-------GVIYGTDG-PVSFNKLIECLKGRSCLSLVGKPKLFFIQACRG -------------TLF-DEGI-----EH--D-A--------------------------- ---KDDTS-EKIPLEADFLFAYSTVS--GY-------------------------YSWRS TANGSWFIQSLCEMLE-------KFS--KTLDLMQIMTRVNHKVATHFESS-SNAPGFSG KKQIPCIVS-----MLTKDFYF-PYESN------------------ >T_guttata_ENSTGUP00000006879 ------------------------------------------------MTDIGDGAHLGK DLADTKS----IPGF--------------------------------------------- ------------------------------------------------------------ ---------------------KGKNLPASKSMDS----GIL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---D-YSYRMDYPEMGECIIINNKNFH--RYT------ -GMSPRSGTDADAASVREVFMKLGYKIKI-NNDLSCEGIFNLLKNVSEE-D--HSKRSSF VCVLLSHGD-E-------GLIYGTDG-PLELKALTSLFRGDRCRSLAGKPKFFFIQACRG -------------TEL-DSGI-----ET--D-SGS------------------------- ---EETMC-QKIPVEADFLYAYSTAP--GY-------------------------YSWRN SAEGSWFIQSLCKMLK-------EHA--RKLELMQILTRVNRRVA-EYESC-STRQDFNA KKQIPCIVS-----MLTKEFYF-P---S------------------ >T_guttata_ENSTGUP00000004278 -----------------------------MSGSERRPPAGHVQLDSRPTLPT-TDGNENI TEVDALN----------------------------------------------------- ------------------------------------------------------------ -----------------------------------IRQSLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EEYKMNHQRRGLALIFNHERFY--WHL------ -RLQDRRGTWVDRNNLKSILTELGFEVRL-FDDLKKEDVQQRIYEASTA-D--HSNADCF VCVFLSHGE-D-------GHIFAYDD-KIEIQTITDMFRGDKCQSLVGKPKIFIIQACRG -------------DKH-DDAV----IAH--D-SADG--SESPG-NET------------- -DVDAAGV-YTLPAGADFIMCYSVAQ--GY-------------------------YSHRD TINGSWYIQDLCETLR-------KHG--SSLEFAELLTVVNRKVSCRRVGM-CKDINAIG KKQIPCFAS-----MLTKKLYF-H---PKSK--------------- >H_sapiens_ENSP00000358327 --------MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANE DSVDAKPDRSSFVPSLFS-KKKK------------------------------------- ------------------------------------------------------------ ------------------NVTM-----RSIKTTR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKLGKCIIINNKNFD--KVT------ -GMGVRNGTDKDAEALFKCFRSLGFDVIV-YNDCSCAKMQDLLKKASEE-D--HTNAACF ACILLSHGE-E-------NVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGRGSWFVQALCSILE-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPHFHE KKQIPCVVS-----MLTKELYF-S---Q------------------ >P_troglodytes_ENSPTRP00000056642 ----------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSW LLAMDEADRRLLRRCRLRLVEEL------------------------------------- ------------------------------------------------------------ -----------QVDQLWDALLSRE-LFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQ AL----PLFISCLEDTGQDMLASFLRT--------------------------------N -----RQAAKL----------------------------------------------SKP TLENLTPVVL-----RPEIRKPEVLR-------------PETPRPVDIGSGGFGDVGA-- LES-----------------LRGNAD-LAYILSMEPCGHCLIINNVNFC--RES------ -GLRTRTGSNIDCEKLRRRFSSLHFMVEV-KGDLTAKEMVLALLELARQ-D--HGALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAS--T-SPEDESPGSNP-EPDATPFQEGLRTF-- --DQLDAI-SSLPTPSDIFVSYSTFP--GF-------------------------VSWRD PKSGSWYVETLDDIFE-------QWA--HSEDLQSLLLRVSAAFL-----------CKGE GRLLRGSVSSWGWGFGVSRAGP-NQ--G------------------ >G_aculeatus_ENSGACP00000023055 ------------------------------MSDTTGDGRGGRVASPNKAATDRAACTENL TETDAL------------------------------------------------------ ------------------------------------------------------------ -----------------------------------IRSSLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EEYKMDNKRRGLALIFNQERFF--WRL------ -GLNDRHGTNADRYNLERRLSNLNFDVRA-YDNLKQEEVLNKINEAAEE-N--HSDSDCF LLVFLSHGE-N-------DQVYTYDG-KISVQDITSLFKGDKCKSLVGKPKIFILQACRG -------------DKH-DDPV----TAC--D-AVD---SELKT-NEV------------- -VVDASVL-HTLPAGADFIMCYSVAE--GY-------------------------YSHRE TINGSWYIQDLCELLQ-------RYG--DSHEFTEVLTLVNRKVSMRSVGN-SSDRSAIG KKQVPCFAS-----MLTKKLYF-R---PKQ---------------- >G_aculeatus_ENSGACP00000005791 ------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESAS GLFSRLRDQGFLSAEQPHLLTELLIIIQRVRLTRD-VDLPAEP---------SSLISPY- -------------------------R----------KMLYNLSEELTADDLKDMKFLLHS YLPRRKLEENVSTLEIWLEMEHKD-LMNEHNLHLLEILISK-VCPMLKDKINQLKAQQ-- -------------------ETPTSPAT--------------------------------Q -----ESGRQGSLSAPNAPNQVPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHL KIEVVETMPPPKNMSCSEPPTSQPSD---------------------------------- --------------------TNTEVL-GTYPMTSAKRGICLIVNNFDFT--KFK------ -NYQNREGTMKDEERLHKVFAWLGFEVEV-KHDCEGEQMLTALRELASR-N--HGQADCL VCCVLSHGD-E-------GCVYGVDGHTVAIKELKEPFNGLNCASLAGKPKLFFIQACQG -------------TGE-QKAV---NVVP--D-GPE------DS-AVC------------- -SDAFKAS-DAIPSEADFLLGMSTVP--SF-------------------------VSYRH RKNGSWFIESLCQNLV-------QMVP--------------------------------- ------------------KL-------------------------- >M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------ -----------------S-KKKK------------------------------------- ------------------------------------------------------------ ------------------NVSG-----QSIKTTR----DRV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKMGKCIIINNKNFD--KVT------ -GMGVRNGTDKDAEALFKCFQSLGFDVIV-HNDCSCAKMKDLLKKASEE-D--HTNAACF ACILLSHGE-E-------NLIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG -------------TEL-DDGI-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGRGSWFVQALCSILE-------EHG--KDLEIMQILTRVNDRVARHFESQ-SDDPCFHE KKQIPCVVS-----MLTKELYF-S---H------------------ >G_gallus_ENSGALP00000019870 -----------------------------MSGAERRPAAGRVQLDSKPTPTTTADGNQNI TEVDAFD----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KRQTFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-VQYKMNHQRRGVALIFNHEHFF--WHL------ -RLPDRRGTLADRNNLKRSLTDLGFEVRI-FDDLKAEDVLKKVFEASRD-D--YSNADCF VCVFLSHGE-N-------DHVYAYDA-QIKIETITNMFRGDKCQSLVGKPKIFIIQACRG -------------DKH-DDPV----LVQ--D-SVDSK-DETTV-NQT------------- -EVDAAGV-YTLPAGADFIMCYSVAQ--GY-------------------------FSHRE TVNGSWYIQDLCEALG-------KHG--SSLEFTELLTVVNRKVSHRKVDI-CRDINAIG KKQIPCFAS-----MLTKKLYF-H---PKSK--------------- >G_gallus_ENSGALP00000013506 LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAM DIFQLLIDEDYLNEEDTFLLAELLYRIKYHSLLSK-LGYTKEKVQECL--HEKGKVSPYR ------------------------------------QMLYELSENITNDMLQEIVFLLRN HLPKRR--RTISALELLILLEKQC-LLTENNVQILEEVFRN-VSPDLLETVKCYRMAKVA LPHQG------------------------------------------------------- -----NTLPIKESSPSYTVHVRLFNSPQGGSFILVLNESYCESLRNKKYSVTGASAACHA ISMPSTGVQNALANTTVCYS---------------------------------------- ---------------------SFLQV-SSYKMDGPRRGICLVINNVKFD----------- GVLQERKGSYKDACELERVFTWLGLDVRT-YTDQTSDQIKELMQAWQRSED--HKNRDCF VCCILSHGE-S-------GAVYGKDGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQACQG -------------KEV-QRPV---YVET--D-ARVPDFSSV------------------- -PQSTSPS-ESIPEEADFLLGMATID--GY-------------------------ASFRH VQEGTWYIQALCSKLQ-------LLVPSRGEDILSILTEVNEDVSKRVD-------RYGT RKQMPQPAY-----TLRRKLIF-P---IPRDPPPS----------- >E_caballus_ENSECAP00000013268 ------------------------------------------------------GEEQNM TEIDAFY----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KREMFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EKYKMDHKRRGIALIFNHERFF--WHL------ -TLPDRRGTSADRDNLMRRFSDLGFEVKC-FNDLKAEELLLKIYEVSTS-S--HADADCF VCVFLSHGE-G-------NHIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG -------------DQH-DVPV----TPL--D-VVDHGTDKLDA-NVT------------- -QVDAASV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TINGSWYIQDLCEMLA-------RFG--SSLEFTELLTLVNRKVSQRRVDF-CKDPSAIG KKQVPCFAS-----MLTKKLHF-F---PKSK--------------- >C_familiaris_ENSCAFP00000016420 -----------------------------------------MADDQDCGMEQAAGDSESP DAVDARPDRSSFVPSLFS-RKKK------------------------------------- ------------------------------------------------------------ ------------------NDSG-----RSIKTAQ----DQV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---T-YQYNMNFEKVGKCIIINNKNFD--KTT------ -GMGVRNGTDKDAEALFKCFRNLGFDVVI-YNDCSCAKMQDLLKKASEE-D--HRNSACF ACILLSHGE-E-------NLIYGTDG-MTAIKDLTAHFRGDRCRTLLEKPKLFFIQACRG -------------TEL-DDGV-----QA--D-SGP---IN-D------------------ --TDANPR-YKIPVEADFLFAYSTVP--GY-------------------------YSWRS PGSGSWFVQALCSTLN-------EHG--KSLEILHILTRVNNRVARHFESQ-SDDPHFHE KKQIPCVVS-----MLTKELYF------------------------ >O_latipes_ENSORLP00000015114 -------------------------------------------------------RSVTQ KCGMQKRDAEALRNCSVCLLKDL------------------------------------- ------------------------------------------------------------ -----------VVDELLIQALVKDGILTQNMAESIMVQKTS--HHRSFKLLLLLPKRGPR AF----KSFCSALKETEQEHLCDLLTQEEEGREVCLDTPL------IN------------ -----SEEQSEVSSSMSYPIHDSE-----------------GLQLEMRTNT-ESMES--- ----------------------------------------------------------SL D-ADSPINTP--VLACSADFYLSHCQ-QSYRMNSSPRGSVLVISNINFDPRAAP------ -ELDPRKGGEVDDEVLRKLFTELDYSVNF-HRDLTAQDMKMVIENFCRRPD--HQKVDSC VVCLLSHGV-D-------GAIYGTDGQQLALDWVFEAFDNAHCPLLQNKPKMFFIQACRG -------------DEM-DCGV----EQI--DGPARTFSPTCEQ-RDAGREEQGD-ADGRQ RASTGRQR-IKLPQRSDMICGFASLK--GT-------------------------AAMRN TKKGSWFIQELNTALR-------LNA--RDTHLADILVQVNKRIKEREGY--APGTAHHR CKEMSEFTS-----SLCKDLYLFPKYQPQC---------------- >O_anatinus_ENSOANP00000005531 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------YRMNRAHRGYCIIFNNYTFK----------- GKLNSRKGTQKDVAELERVFRWLGLDVET-FNDKSRQEMVATLEECSRRPD--HDVRDCL VCCVLSHGE-S-------GAVYSADEELIPIRQIMSYFTAKDCPSLAHKPKLFFIQACQG -------------KDI-QEAV---QIEP--D-ARNPDLDPQPE-PPP------------- -APRESPK-DSIPAEVDFLLGMATVD--GY-------------------------ASFRH VNQGTWYIQALCRQLA-------LLVP-RREDILSILTAVNDDVSQRAD-------HLGK KKQMPQPAF-----TLRRKLVF-P---------------------- >O_anatinus_ENSOANP00000006351 ------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDAL GLFRLLQEKGMLEEGKLFFLKELLFRIHRIDLLTSHLRTSQEDVARELEEPGRAQVSAYS R-----------------------------------VLLFTLSDNVTREELKSITFFLSN DLPRSRLDNKQTLMGIFIEMEKKG-ILGESNLDMLKKICDK-IDKTLLGKIDHYEERR-- ------------------------------------------------------------ -----ADCTLHSSEHLTVLDRDMYIIPIIYDEIILLPTESSFRGHSGGEAEQ-------- ------------------------------------------------------------ ------------------------NG-DFYKMNSNPRGYCLIINNYNFQ--QARAEVPKL KKMKNRDGTDKDAEALSQIFKALAFSPVV-FEDQTAEQILETLQSYQRM-D--HSAQDCF VCCILSHGD-R-------GVVYGTDGQQASIRSLTSYFTGSRCPTLAGKPKLFFIQACQG -------------DAY-HLAV---ALET--D-NGTDKGTAAAS-PAE------------- -PDAVFHE-RCIPDEADFLLGMATVS--NC-------------------------VSYRI PSKGTWYIQSLCHHLR-------NLCP-LGADILTILTKVNFEVSQKID-------LTNR GKQMPQPMF-----TLRKKLVL-PLL-------------------- >C_familiaris_ENSCAFP00000016791 -----------------------------SSAT------------CGLRRAYRTADEQNV TETDAFY----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KREMFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---E-EKYKMDHKRRGIALIFNHERFF--WHL------ -TLPDRRGTSADRDNLVRRFSELGFEVKC-FNDLKAEELLLKIHEASTS-S--HIDADCF LCVFLSHGE-G-------NHIYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRG -------------DQH-DVPV----LPL--D-VVDHRTDKLED-NVT------------- -EVDAASV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCEMLG-------KFG--SSLEFTELLTLVNRKVSQRRVDF-CKDPNAIG KKQVPCFAS-----MLTKKLHF-F---PKSK--------------- >T_guttata_ENSTGUP00000010625 -------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPK AFFEVLQEKDMIGAGNLFFLKELLYRIHRIDLLSTPLGCSREEMERELQLPGRAQVSAYR ------------------------------------QLLYGIAEDLTSEDVRSVKFLLQK QLPKNKLQENASMLQVFLEMEIKG-IIKEDNMTTLKDILQR-FRADIKKKIDAYEEKK-- ------------------------------------------------------------ -----KGLTGSAEVSLELPVSWIDSVDHIKQSTLGLPGEDRS------------------ ------------------------------------------------------------ --------------------LSFQLL-EAYKMTSRPCGVCLILNNHNFA--KAREGVLEH KHMKDRNGTDVDAAALRNVFSKLHFRVEE-YRDLTAEEIRETVNIFQSA-D--HEDKDCF VCCILSHGK-K-------GIIYGVDGQEVPIRELTTSFTAQNCSSLAGKPKVFFIQACQG -------------DAF-HKGV---AIET--D-SVEEDSSLE------------------- -RDARFQL-DCIPAEADFLLGMATLQ--DY-------------------------VSYRS PKEGTWYIQALCQHLE-------YSCP-RGEDVLTILTAVNQEVSKKTC-------ERDA KKQMPQPSF-----TLRKRLIF-PVN-------------------- >M_mulatta_ENSMMUP00000040583 ------------------------------------------------------------ ---MDEADRRLLRRCRLRLVEEL------------------------------------- ------------------------------------------------------------ -----------QVDQLWDALLSRE-LFKPHMIEDIQRAGSGSRRDQARQLITDLETRGSQ AL----PSFISCLVDTGQDMLASFLRT--------------------------------N -----RQAVKL----------------------------------------------SKP TLENLTPVVL-----RPEIRKPEVLR-------------PETPRPVDIGSGGCGDVGA-- PES-----------------LRGNAD-LAYVLSMEPCGHCLIINNVNFC--RES------ -GLSTRTGSSIDCEKLQRRFSLLHFMVEV-KHDLTAKEMVLALLELARR-D--HSALDCC VVVILSHGC-QASHLQFPGAVYGTDGCPVSVERIVNIFNGTSCPSLGGKPKLFFIQACGG -------------EQK-DHGF---EVAS--T-SPEDESSGSNP-EPDATPFQEDLRTF-- --DQLDAV-SSLPTPSDIFVSYSTFP--GF-------------------------VSLRD PKSGSWYIETLDNIFE-------QWA--HSEDLQSLLLRVADAVS-----------VKGI YKQMPGCFN-----FLRKKLFF-KT--S------------------ >T_rubripes_ENSTRUP00000044662 ----------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAG DLFSRLSDQDHLSEEQPHLLVELLGIIQRTKLLRD-HNLPRTGAQDL--------ISPYS CK----------------------SR----------KLLYSLSEELTADDLKDIKFLLNN KLPRGKLEE-VTTLEVFMELEHRA-LISDTDLGFLESIIQP-VCPVLLEKINQFNAQNCK MH----LILHIFDSYLNQIQLNTQLKA--------------------------------L -----W--LIKKF-DSFLVSFSSNESWIG-------GSGNRPT----NRCPLLTAASLLE QS-----------CSFNTLQVGCP-D---------------------------------- --------------------VSVQGV-ETYLMTAAKRGRCLIINNCNFR--VSR------ --LKKREGTMVDEASLDKVLKWLGFEVEI-QRDCTSKKMSSLIQELAKT-S--QRDWDCV MCCVLSHGL-E-------GGVYGVDGGTVEIRKLMEPFSGTNCPSLAGKPKIFFIQACQG -------------SRQ-QDIV---YTDA--G-TPG------HG-YVD------------- -NNAVQAK-ECIPSHADFLLGMATVP--SF-------------------------VSFRD GTHGTWYIQSLCQNLA-------DMVP-RGCDLISILTKVNADVSKKVAWI-----DSGH KTQMPQPAF-----TLTKKIVF-P---APNTPHPV----------- >A_gambiae_AGAP011951-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ECYDTSNARRGIALIINQVIFS----------- -SMAVRVGSSKDRTDISTVLQRIGFEVRV-MDDPNRKQLLSALKQLAGE-D--HSHSDCL VVVVMTHGKEN-------NLLYASDK-SYEANQLWEPFIGDACPSLIGKPKLFFVQACRG -------------KKL-DEGVIQATISI--D-SVDTQ----------------------- -SSPGSMR-YVIPAMADLLVMYSTYD--GH-------------------------YSWRN PSKGSWFIQSLCAELG-------ASA--HCKELLHILTAVSRRVAYHYQSNVPDNAKIDA KKQMPCMVS-----MLTKLLYL-R---PKK---------------- >T_rubripes_ENSTRUP00000045375 ------------------------------------------------------------ ---MEERHKKILQRNRTNLVGEL------------------------------------- ------------------------------------------------------------ -----------DPSSLYDGLIEKR-VFTHDMIDEIKSSG--TRRDQARQLIRDLETRGSR AF----PLFLECLQETGHHTLVELLQD--------------------------------G -----GPAVQIQP-PTPVPIDRPVIQPLPVCKSAIRSRVLRGTM---------------- ------TVKAAPPVDVVRRDKAPVIP-------------VPQPSTAPSPSPEREYMRLKP QGR-----------------IRRDSI-QSYKMDANPSGHCLIINNVDFE--PRS------ -ELNDRKGSNTDCDRLESRFKALNFIVKV-KTNLKQRQIKHELSALSKM-D--HSQYDCC VVVLLSHGT-EVSHSRFPGAVYGVDGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQACGG -------------DEK-DTGF---EVSP--D-EFEPPVVSAHD-QTDAIPMSSSSDSLS- MSDEPDAR-ASLPTPSDILVSYSTFP--GY-------------------------VSWRD TQSGSWYIETLDRILE-------ENA--ATDDLVTMLMMVNHEVSQNQ--------AKGL YKQMPGSFN-----FLRKLLYF-QS--------------------- >A_aegypti_AAEL003444-PA -----------------------------------------------------------M DTTDELDVLGFGSRT--------------------------------------------- ------------------------------------------------------------ -------------------------NESSKSIKEALVSRAA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LDEYYDTTNKRRGIALVFCHMNFS----------- -VMAKRNGADKDRDDICNTLYGLDFDVRV-FDDLSRKEVLDRLKDVSRE-D--HSDNDCL VVVMMSHGE-Q-------GVLYARDN-KYNVDSLWKNFVGNACPSLIGKPKMFFIQACRG -------------EQF-DEGV-----AY--A-AKSPKDMV-DS----------------- --RQEQVL-YSIPAMADLLVMYSTYD--GY-------------------------YSWRN PRQGSWFIQSLCTELD-------ENG--RVRDLLTLLTGVSRRTAYEFQSFVPHNAKMDA MKQIPCIVS-----MLTKTFYF-T---KKTRSRVVTDID------- >D_melanogaster_FBpp0071971 -------------------------------MTDECVTRNYGVGIRSPNGSENRGSFIMA DNTDAKGCTPE------------------------------------------------- ------------------------------------------------------------ -----------------SLVVGGATAASPLPANKFVARMPV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERY-A-SEYNMSHKHRGVALIFNHEFFD--IPS------ --LKSRTGTNVDAQELKKAFENLGFAVSV-HKDCKLRDILKHVGKAAEL-D--HTDNDCL AVAILSHGE-H-------GYLYAKDT-QYKLDNIWHYFTATFCPSLAGKPKLFFIQACQG -------------DRL-DGGI-----TL--E-KGV---TETDG----------------- ---ESSTS-YKIPIHADFLFSYSTIP--GY-------------------------FSWRN INNGSWYMQSLIRELN-------ANG--KKYDLLTLLTFVNQRVALDFESNVPATPMMDR QKQIPCLTS-----MLTRILRF-G---DKPNGNKAG---------- >T_rubripes_ENSTRUP00000024164 ------------------------------------------------------------ --VFLPKDMEAVRRNKTAIGTIF------------------------------------- ------------------------------------------------------------ ---------CADYGLILNKVDEKK-LITRRDYNNLKNINGEDIWGHVIALVDKIMNKGDA TCE--------------------------------------------------------- -----AFLNLLQTDDDIKSTYPELKDTHFNIFFFFYLQD--------------------- ------------------------------------------------------------ ---------------------------EQYELLSQPTGLCVIINNENFL----------- -DMKQRSGTNKDAQSLAEVFTWLGFRVLM-CKDQTKEKMDRALNCFASLVD--PKHGDAF ICCILSHGE-K-------SAVLGIDGEPLCIKQIIRTFKATRQSALVSKPKMFLIQACQG -------------KGT-HRGVLLKDLQT--D----------------------------- ----DCHT-LSIPEEADILVATATVE--DY-------------------------VSFRH KIDGSWFIQSLCQELK-------EGCL-RGEDMTTILHRVNSEVSQKEAFI-----HPGE QKQMPEVRF-----TLRKRLVLSPHTA------------------- >A_gambiae_AGAP011949-PA ------------------------------------------------------------ --MDSILEFEL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KSYDTTHPNRGIAVVINDS-------------- ---ERREGSEKDVQDVVATLEGLKFNVRT-FQDNTKKEIKKALYKVARE-D--HNENDCL VIVAMAHGK-K-------DHITLKKE-KLRIDKLWASFVGNKCPSLIGKPKLVFIQTCRG -------------DNV-DFGV-----AS--H-ETDSTPCSVD------------------ -----PAP-GIIPMYADLLVMYSSYD--RH-------------------------ISVRC KDKGSWFIQSLCQVLR-------ANI--AGKELISLLTQVSYIVSCQT----SITSDGET VKQIPSINS-----MLTKAFYF-V---PKQTQQIS----------- >A_gambiae_AGAP000830-PA ---------------------------MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQ DVNDALGTRKG------------------------------------------------- ------------------------------------------------------------ ---------------------------HDPTNHLVRARMPV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERY-A-CDYNMNHKRRGLALIFNHENFD--VPQ------ --LRSRAGTNVDCENLTASLKGLDFEVHV-FKDLKLRDLQKEVERVSQM-D--HSDADCL LVTILSHGE-L-------GYLYAKDC-QYKLDTIWTYFTANHCPSLAGKPKLFFIQACQG -------------DQL-DGGV-----VL--EAKDR---TETDS----------------- --SSSMLT-FKIPMYADFMIAYSTIP--GF-------------------------YSWRN TQKGSWFIQSLCHELN-------QNG--RKYDLMVLLTFVTQRVAYDFESNTPDIPMMHQ QKQIPCTTS-----MLTRLVYF-N---QKK---------------- >A_gambiae_AGAP004920-PA ------------------------------------------VCGRDILHCKTMNTSTLS TAFDEVDNNTR------------------------------------------------- ------------------------------------------------------------ ---------------VLSLVASVPEIISSSVIHELEPVDD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AHYNMSHNRRGVAAVFNHRKFL----------- -HASERKGTDADCDNIRQVLIYLQFEVRV-YDDLTRKEIKQVLDDLAEE-D--HKNSDCL LVVIMTHGD-D-------DVLHAKDG-TFNVDRLWENFIGDSCPSLLGKPKLFFIQACRG -------------SSF-DTGV-----HF--S-QCM---TQVAKTVVPYAMRELPQPSIVP GCPKSSIQ-YAIPSMADLLVMYSTYK--GH-------------------------YSWRN PSTGSWFIRALCDELR-------EHG--NSKELLQLLTSVSRRVAYEFQSNVPNNSQIDC QKQMPCIVS-----MLTRRIYF-S---KK----------------- >P_troglodytes_ENSPTRP00000028104 -----------------------------MSSA------------SGLRRGHPAGGEENM TETDAFY----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KREMFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EKYKMDHRRRGIALIFNHERFF--WHL------ -TLPERRGTCADRDNLTRRFSDLGFEVKC-FNDLKAEELLLKIHEASTV-S--HADADCF VCVFLSHGE-G-------NHIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG -------------NQH-DVPV----IPL--D-VVDNQTEKLDT-NIT------------- -EVDAASV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCEMLG-------KYG--SSLEFTELLTLVNRKVSQRRVDF-CKDPSAIG KKQVPCFAS-----MLTKKLHF-F---PKSN--------------- >H_sapiens_ENSP00000265164 -----------------------------MSSA------------SGLRRGHPAGGEENM TETDAFY----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KREMFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EKYKMDHRRRGIALIFNHERFF--WHL------ -TLPERRGTCADRDNLTRRFSDLGFEVKC-FNDLKAEELLLKIHEVSTV-S--HADADCF VCVFLSHGE-G-------NHIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG -------------NQH-DVPV----IPL--D-VVDNQTEKLDT-NIT------------- -EVDAASV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCEMLG-------KYG--SSLEFTELLTLVNRKVSQRRVDF-CKDPSAIG KKQVPCFAS-----MLTKKLHF-F---PKSN--------------- >G_aculeatus_ENSGACP00000007379 ------------------------------------------------------------ ---MEEIHKRILQRNRINLVRDL------------------------------------- ------------------------------------------------------------ -----------DPSSLYDGLLEKG-VFTQDMIDEIKSAG--TRRDQARKLVQDLETRGSR AF----AMLLLCLEETDQHGLAELLQR--------------------------------A -----APAVQIWP-AAP---NQPFVLMLNS-----REKTTSPSI-----------QYR-- ---------NPVPVHLTHCD-------------------------AHVTAPERENTLTRP PGR-----------------TRRDSI-QSYKMDASPCGHCLIINNVEFE--PDS------ -ELSNRKGSNIDCDKLEKRFKALNFIVEV-RTNLKQRQIKHALSALSKK-D--HSQCDCC VVIMLSHGT-EVSHNRFPGAVYGVDGQHVPVQLITNYLNGQHCPSLQGKPKLFFIQACGG -------------GER-DTGF---EVSP--D-EVEPSIGGADD-QTDAIPMSSSSDSLS- LSDEVDAR-ATLPTPSDILVSYSTFP--GY-------------------------VSWRD TQSGSWYVETLDQVLE-------QNA--ATDDLVTMLMMVNHEVSQNS--------AKGL YKQMPGSFN-----FLRKLLHF-QT-HA------------------ >T_rubripes_ENSTRUP00000037606 -------------------------------------------------------RSKML HCGMREQDARTLRRQSAVLCKQL------------------------------------- ------------------------------------------------------------ -----------VVDELLIQCLQADDILTESMAESIMAEQTS--QKRSWRLQLLLPKRGPK AF----SSFCSALRATDQQHLCDLLTQ-------TFETNG------NG------------ -----THVETCVDSSVPLPTQEAV-----------------PGVCVCVCET-ESLEV--- ----------------------------------------------------------SL D-ADSPINTP--VLPCTPDFYLSHFQ-QSYKMASSPRGFALVISNVTFNPCAAP------ -ELDPRKGGEVDDEVLRKVFTELEYSVTV-QRDLTAQGIKTCIQNFSGRPE--HRSVDSC VVCLLSHGV-E-------GAVYGIDGELLQLDWVFEAFDNAHCPLLQNKPKMFFIQACRG -------------DEM-DCGV----EQI--DGPSRTSSPSCEQ-RDAGRE---------- ----GRPR-IKLPQRSDMICGFASLK--GQDS-----------------------SHAEH QKRGSWFIQELNTALR-------LHA--RDRHLADILVQVNRRIKDREGY--APGTAHHR CKEMSEFTS-----SLCKDLFLFPKYQPQ----------------- >G_gallus_ENSGALP00000013591 ------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPK AFFQALQEKGMIEVGDLFFLKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPFR ------------------------------------YLLFQLSENITKDDMKCFKFLLGK ELPKCKLSPETTMPDVFIEMEKKG-ILKEDNLTVLKTICGK-VDKSLLKKIEDYE----- ------------------------------------------------------------ -------LNLLGEGEMLVTEGQRSSTGAPEDSAIWLASSVAPDSLGNCD----------- ------------------------------------------------------------ ---------------------QSSQL-EVYKMTSRPRGVCLILNNHNFA--KAREAVPEL RRMKDRNGTHVDADALRKVFSNLHFTVAE-YKDCTAEEIRNIVNNYRCM-D--HNNKDCF VCCILSHGK-K-------GIIYGVDGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQACQG -------------DAY-QKGV---TIET--D-SGEQDYSLE------------------- -TDARFQL-DCIPSEADFLLGMATLQ--DY-------------------------VSYRS PSQGTWYIQSLCQHLE-------SSCP-RGEDILTILTAVNQEVSSKID-------KQNA GKQMPQPSF-----TLRKKLIF-PVN-------------------- >O_latipes_ENSORLP00000003208 ------------------------------------------------------------ ---MEEKHKRILRRNRVHLVKEL------------------------------------- ------------------------------------------------------------ -----------DLSDLCDVLLRKD-VFTQSMINDIKRQNCETKRDQARKLVKDLETRGNE AF----SAFLEGLRVTGQQNLLELLQK--------------------------------S -----APRVHFQP-GKSTEAGYLLIQPHPVYIE--DAVPKKPRT-----------QPSPR KRERRGGGVKVPHNIFIDKVKSDIFD-------------SKSRFRNNDNTNVCTHLTRCS RGQ-----------------RSDHDG-TASRMDARPCGLCLIINNVEFE--PKT------ -ELSIRKGSNVDCDKLEKRFKSLNFVVEV-RTNLKQRQIKSELSALSRK-D--HSIYDCC VVVILSHGT-EVSHNRFPGAVYGVDGNHVSVQEITNYLNGQNCPSLQSKPKIFFIQACGG -------------GEK-DIGF---EVSP--D-EAKPSIGGDGD-QTDAIPFSSSSESLS- TSDETDAI-PTLPTPSDILVSYSTFP--GY-------------------------VSWRA TVSGSWYVEVLDNILE-------EHA--ATLDLTTMLTLVNDKVSQNS--------AKGL YKQMPGSFN-----FLRKHVYF-QT--S------------------ >X_tropicalis_ENSXETP00000008971 ------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQ ELFQQLMTEDLINEDNFFLLKELLYIINHHSLLRN-LGTNKEKVQKAL--PRQGRISPYR ------------------------------------QMLYQLSENIAGDDEKRVYFLLP- --LQKKHKENKTFLEVLCQLEREN-SITEDDVELLEDIFKK-VAPDLLKIIEKYKERGDK LHQTENHLIDPSAPPEDEHELINPPLS--------------------------------- --------IQVSSKDSELWDKGTESLIEHTGMIHEEAEKEDDKSGNINHQLSDLRLNSEM TP---------------------------------------------------------- ---------------------QANKE-EFYDMNHKHRGYCLIIDNSVFM----------- -KGNRREGSDKDAGALSDVFSWLGLEVDI-FENLMSEQIRDCLKRFKSR-D--HSERDCF VCCILTHGE-S-------GTVMGSDDKEVSIREIMSYFTAISCTSLVLKPKLFFIQACQG -------------KFT-HPSS---KVEA--D-AIVP------------------------ -EENKKYV-VNVPKDADFLLGMSTVD--GY-------------------------AAYRH TREGSWYIQALCKNLV-------ELVP-RGEDILAILTKVNKDVSLKEG-------QQGI LKQMPQPSY-----TLLKKLRF-P---VPDVPFRPKTCQENSP--- >P_pygmaeus_ENSPPYP00000016744 -----------------------------MSSV------------SGLRRGHPAGGEENM TETDAFY----------------------------------------------------- ------------------------------------------------------------ -----------------------------------KREMFD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P---A-EKYKMDHRRRGIALIFNHERFF--WHL------ -TLPERRGTCADRDNLTRRFSDLGFEVKC-FNDLKAEELLLKIHEVSTV-S--HADADCF VCVFLSHGE-G-------NHIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG -------------NQH-DVPV----IPL--D-VVDNQTDKLDT-NIT------------- -EVDAASV-YTLPAGADFLMCYSVAE--GY-------------------------YSHRE TVNGSWYIQDLCEMLG-------KYG--SSLEFTELLTLVNRKVSQRRVDF-CKDPSAIG KKQVPCFAS-----MLTKKLHF-F---PKSN--------------- >D_rerio_ENSDARP00000075650 ------------------------------------------------------------ --MDKKESVDKICENKIFLLETL------------------------------------- ------------------------------------------------------------ ---------SVDANFILQHVQQAK-LITLRDYNNLSDFPQR--ETKIINLLDKLMGKGEE TC---------------------------------------------------------- -----HQFIALLRQDCVLENFPMLKDHDIFDS---------------------------- ------------------------------------------------------------ ---------------------SVQEI-SPYRIIKNPRGICVIINNEIFS----------- SGMMSRRGSDKDREYLAKVFHWLGFEVVE-HNNKDTAEIRNILKDLGRTVD-----GDCF VCCILSHGR-R-------EGVCGTDGNYLSIDEIRDPFTGVKCQKLVGKPKLFFIQGCRG -------------ANSLQACV---KVEA--D----AGNSKAKV----------------- --EGDNLD-ITIPSDTDFLIARSTTN--GH-------------------------VSYRH VREGSWFIQSLCRNLE-------KHCP-RGADILTILLYVNNEVSSQKS----------I RKQMPIYEV-----ALTRKLFLRPVNP------------------- >A_gambiae_AGAP012544-PA -----------------------------------------------MDATIINNNHSSL EAMDSTLQLTL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HSYNMAHPKRGIAVVINNN-------------- ---RDRKGSEKDVKALQAVLSHLQFDVRL-LSDKTTVEIRHALKEVSKE-D--HTNNDCL AIIAMAHGY-N-------DRIKFDDD-YLHIDELWTNFVGNKCPSLIGKPKLVFIQSCRG -------------GKL-DYGA-----SI--A-TADARPGLEE------------------ -----PVD-VKIPMYADLLVMYSSFE--HH-------------------------SSIRC RNEGSWFIQSFCQVLG-------ANI--AKTELQALLCHVSYLVSIRSDQ--TIDPEGKV VKQIPMVTS-----MLTKAFYF-V---PK----------------- >C_intestinalis_ENSCINP00000024485 -------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSR--ELETAL DFMEYFEAKGWIQEGDLGFLAEVLYRINRHDLLKLLPGVKNRRDYEENFQAQQNNFTTYR ------------------------------------VVCFMLADELTEGDLKILKRLCAG KMSKANVRRSVDVLSWLTCMEEED-LLSEGDLDFIMSILQHLDNQKPYKLFQRVRMNDNT VTLPKNQQKSNAFQPNSHLPVASGFNS--------------------------------L SKQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEIKDTSTMGI-------------- ------------------------------------------------------------ -------------------------L-DKYPM--ERRGYCLIINNENFE--R-------- ---QDRTGSGNDTERLENLFKEFGFILDV-RKDLDQREMEKVIQEYTKK-D--HSDKDCF VCVVMSHGL-S-------GCVYGVDGLSLSTSKISKSFRPGMCSSLTGKPKIFFFQACQG -------------DRT-MDGH---SAPV--D----------DV-ESD------------- -GAASHGR-QVLPSESDFLIGHSTVP--GY-------------------------LSYRS RTDGSWFISTLVDSLE-------KYH--EKEDLLSIMINVNQEMASK------------P YKQMPMPIA-----TLRKKVFF-S---KQNSNSSSNQNCNTP----