10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -------M----EM-----------GR----------------------------------------------------------------------------------RIHLELRNRTP P_pygmaeus_ENSPPYP00000007477 -------------M-----------GR----------------------------------------------------------------------------------RIHLELRNRTP G_aculeatus_ENSGACP00000022373 -------M----EM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP C_familiaris_ENSCAFP00000025783 -------M----DM-----------DK----------------------------------------------------------------------------------RIHLELRNRTP P_troglodytes_ENSPTRP00000039448 -------------M-----------GR----------------------------------------------------------------------------------RIHLELRNRTP A_carolinensis_ENSACAP00000013586 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP G_gallus_ENSGALP00000013053 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP D_rerio_ENSDARP00000022360 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP X_tropicalis_ENSXETP00000017086 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP M_domestica_ENSMODP00000034651 -------P----SS-----------PH----------------------------------------------------------------------------------SPHFPSHGPFP H_sapiens_ENSP00000329250 -------M----EM-----------GR----------------------------------------------------------------------------------RIHSELRNRAP T_guttata_ENSTGUP00000010000 -------M----EM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP O_anatinus_ENSOANP00000021355 --------------------------------------------------------------------------------------------------------------YHMNLYFCLP B_taurus_ENSBTAP00000016410 -----------------------------------------------------------------------------------------------------------------------P E_caballus_ENSECAP00000002350 -----------------------------------------------------------------------------------------------------------------------P T_nigroviridis_ENSTNIP00000012431 -------M----DM-----------RK----------------------------------------------------------------------------------RIHLELRNRTP M_mulatta_ENSMMUP00000029913 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000082652 -------M----EM-----------DK----------------------------------------------------------------------------------RIYLELRNRTP G_gorilla_ENSGGOP00000015042 -------------M-----------GR----------------------------------------------------------------------------------RIHLELRNRTP T_rubripes_ENSTRUP00000042944 PGPRRSRM----LM-----------RR----------------------------------------------------------------------------------RIHLELRNRTP M_domestica_ENSMODP00000003980 -------V----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP O_latipes_ENSORLP00000002331 -------M----EM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP T_nigroviridis_ENSTNIP00000013976 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP G_gallus_ENSGALP00000002398 -------M----EM-----------KK----------------------------------------------------------------------------------RLTLELRNKKP X_tropicalis_ENSXETP00000022463 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP R_norvegicus_ENSRNOP00000020443 -------L----IL-----------TQ----------------------------------------------------------------------------------KQVKRVTNCRP O_latipes_ENSORLP00000008884 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP P_troglodytes_ENSPTRP00000028434 -------M----EM-----------GR----------------------------------------------------------------------------------RIHSELRNRAP A_carolinensis_ENSACAP00000004238 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP D_rerio_ENSDARP00000033105 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP O_cuniculus_ENSOCUP00000005024 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP A_carolinensis_ENSACAP00000007900 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRNRAP M_mulatta_ENSMMUP00000016055 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP H_sapiens_ENSP00000345848 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP P_pygmaeus_ENSPPYP00000021773 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP P_troglodytes_ENSPTRP00000036180 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP D_rerio_ENSDARP00000071527 -------M----EM-----------KK----------------------------------------------------------------------------------RISLELRNRTP T_rubripes_ENSTRUP00000019528 -------M----DM-----------NK----------------------------------------------------------------------------------RVNLELRHRPP O_anatinus_ENSOANP00000017079 -------F----IF-----------EK----------------------------------------------------------------------------------KLHLFLGTRTP G_aculeatus_ENSGACP00000024521 -------M----DM-----------KK----------------------------------------------------------------------------------RVSLELRHRSP B_taurus_ENSBTAP00000028486 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP O_anatinus_ENSOANP00000020934 -------E----EL-----------KA----------------------------------------------------------------------------------RIHPLIVTALC X_tropicalis_ENSXETP00000034315 -------M----EM-----------KK----------------------------------------------------------------------------------RISLELRNRNP R_norvegicus_ENSRNOP00000043155 -------M----EK-----------DK----------------------------------------------------------------------------------QIYLELQNRTP O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 -------M----DM-----------KK----------------------------------------------------------------------------------RIHLELRNRTP O_latipes_ENSORLP00000025080 -------M----DM-----------NK----------------------------------------------------------------------------------RVSLELRHRSP O_latipes_ENSORLP00000001658 -------M----DM-----------KK----------------------------------------------------------------------------------RITLELRNRSP M_domestica_ENSMODP00000004440 -------M----DI-----------KR----------------------------------------------------------------------------------RLTLELRNRKP E_caballus_ENSECAP00000006868 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRNRAP T_rubripes_ENSTRUP00000027152 -------M----EM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP G_gorilla_ENSGGOP00000011344 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP G_gallus_ENSGALP00000040136 -------M----EM-----------EK----------------------------------------------------------------------------------RINLELRNQAP C_familiaris_ENSCAFP00000003588 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028744 -------M----EM-----------KK----------------------------------------------------------------------------------KINMELKNRAP M_musculus_ENSMUSP00000015893 -------M----EM-----------KK----------------------------------------------------------------------------------KINMELKNRAP O_cuniculus_ENSOCUP00000005451 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRNRAP M_musculus_ENSMUSP00000083521 -------M----DM-----------KR----------------------------------------------------------------------------------RIHLELRNRTP X_tropicalis_ENSXETP00000021012 -------M----EM-----------KK----------------------------------------------------------------------------------RLMLELRNRKA G_aculeatus_ENSGACP00000013165 -------M----DM-----------KK----------------------------------------------------------------------------------RITLELRNRSP C_familiaris_ENSCAFP00000017286 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRNRAP H_sapiens_ENSP00000324074 -------M----EM-----------KK----------------------------------------------------------------------------------KINLELRNRSP P_troglodytes_ENSPTRP00000051813 -------M----EM-----------KK----------------------------------------------------------------------------------KINLELRNRSP B_taurus_ENSBTAP00000022237 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRDRAP T_rubripes_ENSTRUP00000010444 -------M----DM-----------KN----------------------------------------------------------------------------------RVRLELRNRSP O_latipes_ENSORLP00000025809 -------M----EM-----------KK----------------------------------------------------------------------------------RISLELRNRSP G_gorilla_ENSGGOP00000011594 -------M----EM-----------KK----------------------------------------------------------------------------------KINLELRNRSP P_pygmaeus_ENSPPYP00000005091 -------M----EM-----------GK----------------------------------------------------------------------------------QIHLELWNRTP G_aculeatus_ENSGACP00000004164 -------M----EM-----------KK----------------------------------------------------------------------------------RISLELRNRNP T_rubripes_ENSTRUP00000020657 -------M----EM-----------KK----------------------------------------------------------------------------------RISQELGNKNP T_nigroviridis_ENSTNIP00000008152 -------M----DM-----------KK----------------------------------------------------------------------------------RVVLELRNRPP M_domestica_ENSMODP00000023408 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004677 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007165 -------M----KM-----------GR----------------------------------------------------------------------------------RIHLD-RNRTP H_sapiens_ENSP00000266594 -------M----EM-----------GK----------------------------------------------------------------------------------WIHLELRNRTP E_caballus_ENSECAP00000010263 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000363 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005512 -------M----EM-----------KK----------------------------------------------------------------------------------RVSQKLGNKNP R_norvegicus_ENSRNOP00000056793 ------------DI-----------LI----------------------------------------------------------------------------------LLLYENENRLS T_nigroviridis_ENSTNIP00000007469 -------M----DM-----------KN----------------------------------------------------------------------------------RIRLELRNRSP O_cuniculus_ENSOCUP00000008041 -------M----KM-----------KK----------------------------------------------------------------------------------RSNLELRNRAP M_mulatta_ENSMMUP00000016400 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011938 -------M----EM-----------KK----------------------------------------------------------------------------------RINLELRNSAP O_anatinus_ENSOANP00000006726 ---------------------------------------------------------------------------------------------------------------------RAR M_domestica_ENSMODP00000019786 -------M----DI-----------KR----------------------------------------------------------------------------------WLTLELGNRKL O_cuniculus_ENSOCUP00000003696 -------M----EM-----------KK----------------------------------------------------------------------------------KIN-KLRNRAL C_intestinalis_ENSCINP00000018746 -------MSSAGEM-----------LK----------------------------------------------------------------------------------RIQLESRGRQP A_gambiae_AGAP005075-PB -------------M-----------EK----------------------------------------------------------------------------------RILLEKRGRPD A_aegypti_AAEL001605-PA -------------M-----------EK----------------------------------------------------------------------------------RIALEKRGLPD D_melanogaster_FBpp0112004 -------------M-----------EK----------------------------------------------------------------------------------RIELERRARKV G_gorilla_ENSGGOP00000000179 -------M----EM-----------KK----------------------------------------------------------------------------------KINLELRNRSP P_pygmaeus_ENSPPYP00000013309 -------V----NM-----------KR----------------------------------------------------------------------------------RLHLELKHQTP P_pygmaeus_ENSPPYP00000001060 -------M----EM-----------KK----------------------------------------------------------------------------------KINLELRNRSP C_elegans_F33H2.3 ----------MPSM-----------AE----------------------------------------------------------------------------------IYVKELRERDP C_elegans_T19H12.2 -------------M-----------EE----------------------------------------------------------------------------------VYASELRGREP A_aegypti_AAEL012656-PD -------M------------------V----------------------------------------------------------------------------------KLTPDLINQSM A_gambiae_AGAP007670-PB -------M------------------V----------------------------------------------------------------------------------KLTPDLINQSM A_aegypti_AAEL006840-PA -------M------------------V----------------------------------------------------------------------------------KLTPDLINQSM D_melanogaster_FBpp0088015 -------M------------------V----------------------------------------------------------------------------------KLTPELINQSM T_nigroviridis_ENSTNIP00000009472 -------M------------------V----------------------------------------------------------------------------------KLSAELIEQAA T_rubripes_ENSTRUP00000000150 -------M------------------V----------------------------------------------------------------------------------KLSAELIEQAA G_gallus_ENSGALP00000011598 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA A_carolinensis_ENSACAP00000003100 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA C_intestinalis_ENSCINP00000011422 VLTQKLISRGLSNIGTSACGTMHVFLKLNLQGIGLEDISALKSLQHIQELDLSHNNLTDLSALRNMRYLVKLNVSHNELTEVLDFEPPFGLREANFSHNNITKMPGLSTHGHLSILNLEH P_pygmaeus_ENSPPYP00000021193 -------M------------------G----------------------------------------------------------------------------------WITEDLIRRNA T_rubripes_ENSTRUP00000025664 VFFSGFAHMVGLSFFPNLRHLTIVGQE----------------------------------------------------------------------------------LTKIEALEGCP M_mulatta_ENSMMUP00000020530 -------M------------------G----------------------------------------------------------------------------------WITEDLIRRNA B_taurus_ENSBTAP00000018076 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA E_caballus_ENSECAP00000017313 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA O_anatinus_ENSOANP00000018632 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA M_domestica_ENSMODP00000015061 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA G_aculeatus_ENSGACP00000013527 -------------MESKRDKDQEADCE----------------------------------------------------------------------------------KITAVLLKSRT M_musculus_ENSMUSP00000032723 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA R_norvegicus_ENSRNOP00000016758 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA C_familiaris_ENSCAFP00000015542 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA H_sapiens_ENSP00000254193 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA M_mulatta_ENSMMUP00000015518 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA P_pygmaeus_ENSPPYP00000007744 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA P_troglodytes_ENSPTRP00000041754 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAA H_sapiens_ENSP00000250173 -------M------------------G----------------------------------------------------------------------------------WITEDLIRRNA P_troglodytes_ENSPTRP00000035210 -------M------------------G----------------------------------------------------------------------------------WITEDLIRRNA R_norvegicus_ENSRNOP00000037753 -------MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRPQNPP------------------------------------------------------SMWTKVSSQQP E_caballus_ENSECAP00000002990 -------M------------------G----------------------------------------------------------------------------------RITEDLIRRNA G_gorilla_ENSGGOP00000008764 -------M------------------V----------------------------------------------------------------------------------KLTAELIEQAX 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 --S-DVKELV-LDN-C---------RSIEGKIEG-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 --S-DVKELV-LDN-C---------RSYEGKIEG-------------------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 --A-DVKELV-LDN-C---------RSKEGKIEG-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 --L-QVKELV-LDN-C---------RSYDGKIEG-------------------------------------------------------------------------------------- H_sapiens_ENSP00000329250 --S-DVKELA-LDN-S---------RSNEGKLEA-------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010000 --S-DVKELV-LDN-C---------RSYEGKIVG-------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 LAR-RLKSFV-LDN-C---------RS-KGKIEG-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 --S-QVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 --F-QVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 -----VKELV-LDN-S---------RSNEGKLEG-------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 --S-DVKELV-LDN-C---------KSIEGKIEG-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 --S-DVKELV-LDN-S---------RSNEGKXEG-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 --S-DVQELV-LDN-C---------RSTEGKIVG-------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 --G-EVKELV-LDN-C---------RSDDGKIVG-------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 --S-DVRELV-LDN-C---------RAHEGKIEG-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 --F-KVKELV-LDN-C---------RSIEGKIEG-------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 --S-DVRELV-LDN-C---------RSIEGKIEG-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 --S-DVKELA-LDK-S---------RSNEGKLEA-------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 --P-DVQELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 --S-DVRELV-LDN-C---------RSNEGKIEG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 --E-KVTELV-LDN-C---------RSSNGEIEG-------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- H_sapiens_ENSP00000345848 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 --A-EVAELV-VDN-C---------RSSDGEIEG-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 --S-EVKELV-LDN-C---------RSDDGKIEG-------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 C-A-QVKELV-LDN-C---------RSDEGKIEG-------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 --T-EVQELV-LDN-C---------RSGEGKIEG-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028486 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 --P-QVKELV-LDN-C---------RSEDGRIVG-------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 --S-EVAELV-LDN-C---------RSVDGEIEG-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 --S-DVKELV-LDN-C---------QSTEGKMEG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 -----VKELV-LDN-C---------RSNEGKIEA-------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022955 --S-DVRELV-LDN-C---------RSVEGKIEG-------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025080 --S-EVHELV-LDN-C---------RSGDGKMEG-------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 --A-EIVELV-LDN-S---------RSADGEVEG-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 --G-EVKDLV-LDN-C---------SSEDGKIGG-------------------------------------------------------------------------------------- E_caballus_ENSECAP00000006868 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 --S-DVRELV-LDN-C---------RSTEGKIQG-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- G_gallus_ENSGALP00000040136 --RGDVTELV-LDN-C---------KSSNGEIEG-------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 -----VRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 --A-AVRELV-LDN-C---------KAMDGKIEG-------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 --A-DVKELV-LDN-C---------RSDDGKIIG-------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 --A-EIAELV-VDN-S---------RCADGEVDG-------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- H_sapiens_ENSP00000324074 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 --A-EVLELI-LDN-C---------RSTDGEIEG-------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 --T-EVGELV-VDN-C---------RSSDGEVEG-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 --S-DVKELV-LDN-S---------RSNEG------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 --A-DVVELV-VDN-C---------RSSDGEVEG-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 --A-EVVDLL-VDN-C---------QSGDGEVEG-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 --S-EVKELV-LDN-C---------RS-NGKVEG-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023408 ----QVTELV-LDN-C---------HSVNGEIEG-------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ----QVTELV-LDN-C---------RSSNGEIEG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 --S-DVKELV-LDN-S---------RLNEGKLEG-------------------------------------------------------------------------------------- H_sapiens_ENSP00000266594 --S-DVKELF-LDN-S---------QSNEGKLEG-------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010263 -----VRELV-LDN-C---------KSNDGKIEG-------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 ----QVKELV-LDN-C---------RTEDGKVVG-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 --A-EVVELL-VDN-C---------LSGDGEVEG-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 --S-AVQELV-LDN-C---------KANDGKIEG-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 --A-EVLELI-LDN-C---------RSADGDLEG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 ----QVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 --E-EVTELV-LDN-C---------LCVSEKIED-------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 --L-QVTELV-LDN-C---------HSVNGEIEG-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 --G-EVKDLL-LDN-C---------SSEDGKIGG-------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003696 --E-DVIQLV-LDN-C---------PCVNGEIEG-------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 --E-QIEDLI-LDN-C---------RSA-GEPEG-------------------------------------------------------------------------------------- A_gambiae_AGAP005075-PB --D-EITELI-LDN-C---------RST--YIDG-------------------------------------------------------------------------------------- A_aegypti_AAEL001605-PA --D-KITELI-LDN-C---------RST--SIEG-------------------------------------------------------------------------------------- D_melanogaster_FBpp0112004 --N-QITELN-LDN-C---------RST--SIVG-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000179 --E-EXXXXX-XXX-X---------XXXXXXXXX-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013309 --P-AVLKLV-LDN-C---------QSSDGEIEG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------------------------------------------------------------------- C_elegans_F33H2.3 --A-TVDTLF-LDN------------AEDGQIGG-------------------------------------------------------------------------------------- C_elegans_T19H12.2 --E-TVDTLF-LDN------------TQGGVIGG-------------------------------------------------------------------------------------- A_aegypti_AAEL012656-PD QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------------------------------------------------------------------- A_gambiae_AGAP007670-PB QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------------------------------------------------------------------- A_aegypti_AAEL006840-PA QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------------------------------------------------------------------- D_melanogaster_FBpp0088015 QYINPCRERE-LDL-R---------GYKIPQIEN-------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 QYTQ-VRDRE-LDLAR---------GYKIPVIEN-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 QYTNPVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- G_gallus_ENSGALP00000011598 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 --N-RIEEVEGLSN-CSYLQKLVLSRNLIQNISG-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 ----LLEELW-VAE-C---------RLT--EISG-------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000020530 EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018076 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017313 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000018632 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- M_domestica_ENSMODP00000015061 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 GEF-DLESILFLKL-----------RGLGIHDLG-------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- H_sapiens_ENSP00000254193 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- H_sapiens_ENSP00000250173 EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 IKL-AIRDLP-NDEITVTDKDP---PEASSEVEGEMLAPQDTVIIGEAAPSIAMEDTPNPPITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGRQRVKSYTPKPRGGR E_caballus_ENSECAP00000002990 EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------------------------------------------------------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 ---------------L---------------------TDEFEGLE--------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- H_sapiens_ENSP00000329250 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- T_guttata_ENSTGUP00000010000 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 ---------------L---------------------SDEFEELE--------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 ---------------L---------------------TEEFVNLE--------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 ---------------L---------------------SSDFENLE--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 ---------------L---------------------TEEFEELE--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 ---------------L---------------------SGEFVNLE--------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 ---------------L---------------------SDTFKELE--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- H_sapiens_ENSP00000345848 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 ---------------L---------------------TDDFKELE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 ---------------I---------------------TAEFSNLE--------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ---------------I---------------------TEEFSNLE--------------------------------------------------------------------------- B_taurus_ENSBTAP00000028486 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 ---------------L---------------------SSDFDSLE--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 ---------------L---------------------NDTYKELE--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 ---------------F---------------------MDEFEELK--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022955 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- O_latipes_ENSORLP00000025080 ---------------I---------------------TEEFSNLE--------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 ---------------L---------------------TDEFTELE--------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 ---------------L---------------------SSEFENLE--------------------------------------------------------------------------- E_caballus_ENSECAP00000006868 ---------------L---------------------NDAFKKLE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 ---------------L---------------------TEEFVNLE--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- G_gallus_ENSGALP00000040136 ---------------L---------------------NDSFKELE--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 ---------------L---------------------TDEFVNLE--------------------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 ---------------L---------------------TSEFENLE--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 ---------------L---------------------TEAFTGLE--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 ---------------L---------------------NDTFKKLE--------------------------------------------------------------------------- H_sapiens_ENSP00000324074 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 ---------------L---------------------NDTFKKLE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 ---------------L---------------------TNEFSELE--------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 ---------------L---------------------SEEFTELE--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 -------------------------------------------LE--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000004164 ---------------L---------------------SEEYVALE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 ---------------L---------------------TDEYTELE--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 ---------------I---------------------TAEFCNLE--------------------------------------------------------------------------- M_domestica_ENSMODP00000023408 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ---------------L---------------------NDSFKELQ--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ---------------L---------------------TDESEELE--------------------------------------------------------------------------- H_sapiens_ENSP00000266594 ---------------L---------------------TDEFEELE--------------------------------------------------------------------------- E_caballus_ENSECAP00000010263 ---------------L---------------------TAEFVNLE--------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 ---------------L---------------------SSDFENLE--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 ---------------L---------------------TDEYTGLE--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 ---------------L---------------------TDEFVNLE--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 ---------------L---------------------TSDFCELE--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 ---------------L---------------------KDTLKQLE--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 ---------------L---------------------NDTFKELG--------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 ---------------L---------------------SDTFKELE--------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 ---------------L---------------------TSEFENLE--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003696 ---------------L---------------------KDTFK-LA--------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 ---------------L---------------------TDEFTSLK--------------------------------------------------------------------------- A_gambiae_AGAP005075-PB ---------------L---------------------TDSFTALE--------------------------------------------------------------------------- A_aegypti_AAEL001605-PA ---------------L---------------------TDSFTALE--------------------------------------------------------------------------- D_melanogaster_FBpp0112004 ---------------L---------------------TDEYTALE--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000179 ---------------X---------------------XXXXXXXX--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013309 ---------------F---------------------TVEFLNLE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 ---------------L---------------------NDTFKELE--------------------------------------------------------------------------- C_elegans_F33H2.3 ---------------L---------------------TDQLINLE--------------------------------------------------------------------------- C_elegans_T19H12.2 ---------------I---------------------NEKLTKLE--------------------------------------------------------------------------- A_aegypti_AAEL012656-PD ---------------M---------------------GATLDQFD--------------------------------------------------------------------------- A_gambiae_AGAP007670-PB ---------------M---------------------GATLDQYD--------------------------------------------------------------------------- A_aegypti_AAEL006840-PA ---------------M---------------------GATLDQFD--------------------------------------------------------------------------- D_melanogaster_FBpp0088015 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- G_gallus_ENSGALP00000011598 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 ---------------F-----------------------ENLNLR--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 ---------------LEHI------------------DKWCRDLK--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 ---------------LDKCLQLKKLYLYDNQISEINNVEFLINLD--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000020530 ---------------LEHI------------------DKWCRDLK--------------------------------------------------------------------------- B_taurus_ENSBTAP00000018076 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- E_caballus_ENSECAP00000017313 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- O_anatinus_ENSOANP00000018632 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- M_domestica_ENSMODP00000015061 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ---------------C---------------------LGECMSLE--------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- H_sapiens_ENSP00000254193 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- H_sapiens_ENSP00000250173 ---------------LEHI------------------DKWCRDLK--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 ---------------LEHI------------------DKWCRDLK--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 KSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRMLEPRSERTAGKTSLKRMVPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTPLRAVLQPTPATSEEQVTA E_caballus_ENSECAP00000002990 ---------------LEHI------------------DKWCRDLK--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 ---------------L---------------------GATLDQFD--------------------------------------------------------------------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007477 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022373 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000025783 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000039448 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013586 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013053 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000022360 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017086 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034651 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329250 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010000 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021355 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016410 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002350 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012431 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029913 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000082652 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015042 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042944 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000003980 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000002331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013976 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002398 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000022463 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020443 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008884 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028434 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000004238 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000033105 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005024 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007900 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016055 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000345848 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021773 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036180 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071527 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019528 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017079 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020934 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000034315 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000043155 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000025080 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001658 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027152 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011344 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000040136 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003588 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028744 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000015893 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005451 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000083521 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000021012 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013165 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017286 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000324074 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000051813 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000022237 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010444 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000025809 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011594 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020657 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023408 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004677 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000363 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005512 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056793 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007469 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008041 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016400 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011938 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000006726 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018746 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005075-PB ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001605-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112004 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001060 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33H2.3 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T19H12.2 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012656-PD ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007670-PB ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006840-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0088015 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009472 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000150 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000011598 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003100 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011422 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021193 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000025664 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000020530 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018076 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017313 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018632 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000015061 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013527 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000032723 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000016758 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015542 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000254193 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015518 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000041754 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250173 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035210 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000037753 SIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDREKRPSTAHGTLVTPQVKAVLTTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPSALPPGWPNLHPKAEYPPDLFSV E_caballus_ENSECAP00000002990 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008764 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ---------------------------------------------------------------------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L P_pygmaeus_ENSPPYP00000007477 ---------------------------------------------------------------------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L G_aculeatus_ENSGACP00000022373 ---------------------------------------------------------------------FLSTINVGLTTVSH-------------------------LPRLNKLKK--L C_familiaris_ENSCAFP00000025783 ---------------------------------------------------------------------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L P_troglodytes_ENSPTRP00000039448 ---------------------------------------------------------------------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L A_carolinensis_ENSACAP00000013586 ---------------------------------------------------------------------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L G_gallus_ENSGALP00000013053 ---------------------------------------------------------------------FLSTINVGLASVAN-------------------------LPKLNKLKK--L D_rerio_ENSDARP00000022360 ---------------------------------------------------------------------FLSTINVGLTSVTN-------------------------LPKLNKLKK--L X_tropicalis_ENSXETP00000017086 ---------------------------------------------------------------------FLSTINVCLSSIAN-------------------------LPKLNKLKK--L M_domestica_ENSMODP00000034651 ---------------------------------------------------------------------FLSTINAGISSVAN-------------------------LPKLNKLKK--L H_sapiens_ENSP00000329250 ---------------------------------------------------------------------FLSKINGGLTSISD-------------------------LPKL-KLRK--L T_guttata_ENSTGUP00000010000 ---------------------------------------------------------------------YLSTINVGLTSVAN-------------------------LPKLNKLKK--L O_anatinus_ENSOANP00000021355 ---------------------------------------------------------------------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L B_taurus_ENSBTAP00000016410 ---------------------------------------------------------------------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L E_caballus_ENSECAP00000002350 ---------------------------------------------------------------------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L T_nigroviridis_ENSTNIP00000012431 ---------------------------------------------------------------------FLSTINVGLTTVAH-------------------------LPKLNKLKK--L M_mulatta_ENSMMUP00000029913 ---------------------------------------------------------------------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L M_musculus_ENSMUSP00000082652 ---------------------------------------------------------------------FLSTINVGLTSISN-------------------------LPKLNKLKK--L G_gorilla_ENSGGOP00000015042 ---------------------------------------------------------------------FLXTINVGLTSIAN-------------------------LPKLNKLKK--L T_rubripes_ENSTRUP00000042944 ---------------------------------------------------------------------FLSTINVGLTTVAH-------------------------LPKLNKLKK--L M_domestica_ENSMODP00000003980 ---------------------------------------------------------------------FLSLISVGLSTVSN-------------------------LPELPKLKK--L O_latipes_ENSORLP00000002331 ---------------------------------------------------------------------FLSTINVGLTTVAH-------------------------LPKLKKLKK--L T_nigroviridis_ENSTNIP00000013976 ---------------------------------------------------------------------FLSLINVGLTSVFN-------------------------LPKLEKLKK--L G_gallus_ENSGALP00000002398 ---------------------------------------------------------------------FLSMINVNLLSISN-------------------------LPKLNKLRK--L X_tropicalis_ENSXETP00000022463 ---------------------------------------------------------------------FLSLINVLLMSVSN-------------------------LPKLPKLKK--L R_norvegicus_ENSRNOP00000020443 ---------------------------------------------------------------------FLSTINVGLTSISN-------------------------LPKLNKLKK--L O_latipes_ENSORLP00000008884 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLAKLKK--L P_troglodytes_ENSPTRP00000028434 ---------------------------------------------------------------------FLSTINGGLTSISD-------------------------LTKL-KLRK--L A_carolinensis_ENSACAP00000004238 ---------------------------------------------------------------------FLSLINVGLASVLN-------------------------LPKLPKLKKDDL D_rerio_ENSDARP00000033105 ---------------------------------------------------------------------FLSLINVGLLSVSN-------------------------LPKLGKLKK--L O_cuniculus_ENSOCUP00000005024 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L A_carolinensis_ENSACAP00000007900 ---------------------------------------------------------------------FLSMANVELTSLAK-------------------------LPALNKLRK--L M_mulatta_ENSMMUP00000016055 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L H_sapiens_ENSP00000345848 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L P_pygmaeus_ENSPPYP00000021773 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L P_troglodytes_ENSPTRP00000036180 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L D_rerio_ENSDARP00000071527 ---------------------------------------------------------------------FLSMVNVGLTSLAK-------------------------LPSLPKLRK--L T_rubripes_ENSTRUP00000019528 ---------------------------------------------------------------------LLSLINVGLSSVAE-------------------------IPKLDKLKK--L O_anatinus_ENSOANP00000017079 ---------------------------------------------------------------------FLSLINVVLISVSN-------------------------LPKLPKLRK--L G_aculeatus_ENSGACP00000024521 ---------------------------------------------------------------------LLSLINVGLTSVAD-------------------------IPKLDKLKK--L B_taurus_ENSBTAP00000028486 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L O_anatinus_ENSOANP00000020934 ---------------------------------------------------------------------FLSMININLLSVSN-------------------------LPKLSRLRK--L X_tropicalis_ENSXETP00000034315 ---------------------------------------------------------------------FLSMANVELKSLSK-------------------------LPKLPKLRK--L R_norvegicus_ENSRNOP00000043155 ---------------------------------------------------------------------FLSTINVDLTSILN-------------------------LPKLSKLKK--L O_cuniculus_ENSOCUP00000000076 ---------------------------------------------------------------------FLSTINVGLVSVAN-------------------------LPKLNKLKK--L G_aculeatus_ENSGACP00000022955 ---------------------------------------------------------------------FLSLINVGLMSVSN-------------------------LPKLAKLKK--L O_latipes_ENSORLP00000025080 ---------------------------------------------------------------------VLSLINVGLTSMAG-------------------------IPKLDKLKK--L O_latipes_ENSORLP00000001658 ---------------------------------------------------------------------FLSMVNVGLSSLTK-------------------------LPPLPKLRK--L M_domestica_ENSMODP00000004440 ---------------------------------------------------------------------FLSMISINLVSLAN-------------------------LPKLPRLQK--L E_caballus_ENSECAP00000006868 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L T_rubripes_ENSTRUP00000027152 ---------------------------------------------------------------------FLSLINVGLVSVAN-------------------------LPKLAKLKK--L G_gorilla_ENSGGOP00000011344 ---------------------------------------------------------------------FLXXXXXXXXXXXX-------------------------XXXXXXXXX--L G_gallus_ENSGALP00000040136 ---------------------------------------------------------------------FLSMANVQLTSLAK-------------------------LPTLSKLRK--L C_familiaris_ENSCAFP00000003588 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L R_norvegicus_ENSRNOP00000028744 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L M_musculus_ENSMUSP00000015893 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L O_cuniculus_ENSOCUP00000005451 ---------------------------------------------------------------------FLSMANVELSSLAQ-------------------------LPSLNKLRK--L M_musculus_ENSMUSP00000083521 ---------------------------------------------------------------------FLSLISVGLFSVSD-------------------------LPKLPKLKK--L X_tropicalis_ENSXETP00000021012 ---------------------------------------------------------------------FLSMINVNLLSVAN-------------------------LPKLPKLKK--L G_aculeatus_ENSGACP00000013165 ---------------------------------------------------------------------FLSMVNVGLSSLAK-------------------------LPSLPKLHK--L C_familiaris_ENSCAFP00000017286 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L H_sapiens_ENSP00000324074 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L P_troglodytes_ENSPTRP00000051813 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L B_taurus_ENSBTAP00000022237 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L T_rubripes_ENSTRUP00000010444 ---------------------------------------------------------------------YLSLVNVGLGSLAK-------------------------VPSLPKLRK--L O_latipes_ENSORLP00000025809 ---------------------------------------------------------------------VLSMVNVGLSSLSK-------------------------MPLLPKLQK--L G_gorilla_ENSGGOP00000011594 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L P_pygmaeus_ENSPPYP00000005091 ---------------------------------------------------------------------FLSTINVGLTSITN-------------------------LPRANKLKK--L G_aculeatus_ENSGACP00000004164 ---------------------------------------------------------------------VLSMVNIGLSSLAK-------------------------LPSLPKLRK--L T_rubripes_ENSTRUP00000020657 ---------------------------------------------------------------------VLSMVNVGLKSLAK-------------------------LPSLPKLRK--L T_nigroviridis_ENSTNIP00000008152 ---------------------------------------------------------------------LLSLISVGLCSVAD-------------------------VPKLDKLKK--L M_domestica_ENSMODP00000023408 ---------------------------------------------------------------------FLSMVRVELTSLAQ-------------------------LPSLSKLRK--L T_guttata_ENSTGUP00000004677 ---------------------------------------------------------------------FLSMANVELTSLAK-------------------------LPTLSKLRK--L P_pygmaeus_ENSPPYP00000007165 ---------------------------------------------------------------------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L H_sapiens_ENSP00000266594 ---------------------------------------------------------------------LLNTINIGLTSIAN-------------------------LPKLNKLKK--L E_caballus_ENSECAP00000010263 ---------------------------------------------------------------------FLSLINVGLISVSN-------------------------LPKLPKLKK--L T_guttata_ENSTGUP00000000363 ---------------------------------------------------------------------FLSMININLLSVSN-------------------------LPKLNKLRK--L T_nigroviridis_ENSTNIP00000005512 ---------------------------------------------------------------------VLSMVNVGLKSLSK-------------------------LPPLPKLRK--L R_norvegicus_ENSRNOP00000056793 ---------------------------------------------------------------------FLSLINVGLFSVSD-------------------------LPKLPKLKK--L T_nigroviridis_ENSTNIP00000007469 ---------------------------------------------------------------------YLSLVNVGLASLAR-------------------------VPSLPRLRK--L O_cuniculus_ENSOCUP00000008041 ---------------------------------------------------------------------FLSMANVELRSLAQ-------------------------LPSLNKLQK--L M_mulatta_ENSMMUP00000016400 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--L O_cuniculus_ENSOCUP00000011938 ---------------------------------------------------------------------FLSMANVELSSLAQ-------------------------IPSLNKLRK--L O_anatinus_ENSOANP00000006726 ---------------------------------------------------------------------FLSLANVELTSLAR-------------------------LPSLSKLRK--L M_domestica_ENSMODP00000019786 ---------------------------------------------------------------------FLSMISIYLVSLVN-------------------------LPKLP------- O_cuniculus_ENSOCUP00000003696 ---------------------------------------------------------------------FLSMPNVELSYLAQ-------------------------LPILNKLQK--L C_intestinalis_ENSCINP00000018746 ---------------------------------------------------------------------KLSMINTGITSLKG-------------------------FPALPALKK--L A_gambiae_AGAP005075-PB ---------------------------------------------------------------------TLSLINVGLVSLKN-------------------------FPKLSNLRK--L A_aegypti_AAEL001605-PA ---------------------------------------------------------------------VLSLINVGLVSLKN-------------------------FPKLPALRK--L D_melanogaster_FBpp0112004 ---------------------------------------------------------------------SLSLINVGLTTLKG-------------------------FPKLPNLKK--L G_gorilla_ENSGGOP00000000179 ---------------------------------------------------------------------XXXXXXXXXXXXXX-------------------------XXXXXXXXX--L P_pygmaeus_ENSPPYP00000013309 ---------------------------------------------------------------------FLHLITVGLISFSN-------------------------L----------F P_pygmaeus_ENSPPYP00000001060 ---------------------------------------------------------------------FLSMANVELSSLAR-------------------------LPSLNKLRK--- C_elegans_F33H2.3 ---------------------------------------------------------------------MLSMVKCGLTTLAG-------------------------FPTLPALTY--L C_elegans_T19H12.2 ---------------------------------------------------------------------LLSMVKCGLTTLKG-------------------------MPVLPALNY--L A_aegypti_AAEL012656-PD ---------------------------------------------------------------------TIDFSDNDIRKLDG-------------------------FPHLPRLKC--L A_gambiae_AGAP007670-PB ---------------------------------------------------------------------TIDFSDNDIRKLDG-------------------------FPRLARLKC--L A_aegypti_AAEL006840-PA ---------------------------------------------------------------------TIDFSDNDIRKLDG-------------------------FPHLPRLKC--L D_melanogaster_FBpp0088015 ---------------------------------------------------------------------TIDLSDNDLRKLDN-------------------------LPHLPRLKC--L T_nigroviridis_ENSTNIP00000009472 ---------------------------------------------------------------------TIDFSDNEVRKLDG-------------------------FPLLRRLKT--L T_rubripes_ENSTRUP00000000150 ---------------------------------------------------------------------TLDFSDNEVRKLDG-------------------------FPLLRRLKT--L G_gallus_ENSGALP00000011598 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L A_carolinensis_ENSACAP00000003100 ---------------------------------------------------------------------SIDFSDNEIRKLDG-------------------------FPLLKRLKT--L C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------MPVLPALNY--L T_guttata_ENSTGUP00000009232 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L C_intestinalis_ENSCINP00000011422 ---------------------------------------------------------------------VLELAHNKLTQIEN-------------------------LETVQQLQE--L P_pygmaeus_ENSPPYP00000021193 ---------------------------------------------------------------------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L T_rubripes_ENSTRUP00000025664 ---------------------------------------------------------------------VLWLNSNSISRIQG-------------------------LNRLQNLLE--L M_mulatta_ENSMMUP00000020530 ---------------------------------------------------------------------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L B_taurus_ENSBTAP00000018076 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L E_caballus_ENSECAP00000017313 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L O_anatinus_ENSOANP00000018632 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L M_domestica_ENSMODP00000015061 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLKRLKT--L G_aculeatus_ENSGACP00000013527 ---------------------------------------------------------------------KLDLSANNITNLAP-------------------------LASLRLLSV--L M_musculus_ENSMUSP00000032723 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L R_norvegicus_ENSRNOP00000016758 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L C_familiaris_ENSCAFP00000015542 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L H_sapiens_ENSP00000254193 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L M_mulatta_ENSMMUP00000015518 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L P_pygmaeus_ENSPPYP00000007744 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L P_troglodytes_ENSPTRP00000041754 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L H_sapiens_ENSP00000250173 ---------------------------------------------------------------------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L P_troglodytes_ENSPTRP00000035210 ---------------------------------------------------------------------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L R_norvegicus_ENSRNOP00000037753 EDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYIL E_caballus_ENSECAP00000002990 ---------------------------------------------------------------------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L G_gorilla_ENSGGOP00000008764 ---------------------------------------------------------------------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--X 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ P_pygmaeus_ENSPPYP00000007477 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ G_aculeatus_ENSGACP00000022373 ELS-------DNRI--SGGLEVLAAKCPNLTHLNLSGNKIKDLSTIEPLKELATLKSLDL------FNCE-VTNLNEYRDNVFKLLPQLTYLDGY------DKD--DK------------ C_familiaris_ENSCAFP00000025783 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ P_troglodytes_ENSPTRP00000039448 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ A_carolinensis_ENSACAP00000013586 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLEKLENLKSLDL------FNCE-VTNLNDYRDNVFKLLPQLTYLDGY------DRD--DK------------ G_gallus_ENSGALP00000013053 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLGTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ D_rerio_ENSDARP00000022360 ELS-------DNRI--SGGLEVLAGKCPNLTHLNLSGNKIKDLSTIEPLKKLESLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DKE--DK------------ X_tropicalis_ENSXETP00000017086 ELS-------DNNI--SGGLEVLAEKCPNLTHLNLSGNRIKDLSTIEPLKKLEHLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ M_domestica_ENSMODP00000034651 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIDPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ H_sapiens_ENSP00000329250 EL----------RV--SGGLEVLAEKCPNLTHLYLSGNKIKDLSTIEPLKQLENLKSLDL------FNCE-VTNLNDYGENVFKLLLQLTYLDSC------YWD--HK------------ T_guttata_ENSTGUP00000010000 ELG-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKLKDLGTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ O_anatinus_ENSOANP00000021355 ELS-------DNRL--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ B_taurus_ENSBTAP00000016410 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ E_caballus_ENSECAP00000002350 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ T_nigroviridis_ENSTNIP00000012431 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKDLGTLKSLDL------FNCE-VTNLNEYRDSVFKLLPQLTYLDGY------DKD--DK------------ M_mulatta_ENSMMUP00000029913 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ M_musculus_ENSMUSP00000082652 ELS-------ENRI--SGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNAYRENVFKLLPQVMYLDGY------DRD--NK------------ G_gorilla_ENSGGOP00000015042 ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLXXLDL------FNCE-VTNLNDYREXVFKLLPQLTYLXGY------DRD--DK------------ T_rubripes_ENSTRUP00000042944 ELS-------DNRI--SGGLEVLVEKCPNLTHLNLSCNKIEDLSTIEPLKELGTLKSLDL------YNCE-VTNLSEYRDSVFKLLPQLTYLDGY------DKD--DK------------ M_domestica_ENSMODP00000003980 ELS-------DNRI--FGGLDVLAEKLPNLTHLNLSGNNLKDISTLEPLKKLEYLKSLDL------FNCE-VTNLNDYRESVFTLLPQLTYLDGY------DQE--DK------------ O_latipes_ENSORLP00000002331 ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIGPLKELGALKSLDL------FNCE-VTNLNEYRDNVFKLLPQLTYLDGY------DKD--DK------------ T_nigroviridis_ENSTNIP00000013976 ELS-------DNRI--SSGLDVLAVKLPNLRHLNLSGNKLKDISTLEPLKKLENLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DIE--DR------------ G_gallus_ENSGALP00000002398 ELS-------DNRI--SGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDL------FNCE-VTMLINYRESVFTLLPQLTYLDGF------DAD--EQ------------ X_tropicalis_ENSXETP00000022463 ELS-------DNRI--SGGLDVLAEKLSNLTHLNLSGNKIKDISTLEPLKKLESLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DK------------ R_norvegicus_ENSRNOP00000020443 ELS-------ENRI--SGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-VTNLNAYRENVFKLLPQVMYLDGY------DRD--NK------------ O_latipes_ENSORLP00000008884 ELS-------DNRI--SGGLDVLAEKLPHLTHLNLSGNKLKDLSTLEPLKKLDNLKSLDL------FNCE-VTNLNDYRDSVFKLLPQLTYLDGY------DIA--DR------------ P_troglodytes_ENSPTRP00000028434 EL----------RV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKQLENLKSLDL------FNCK-VTNLNDFRENVFKLLLQLTYLDSC------YWD--HK------------ A_carolinensis_ENSACAP00000004238 ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDIGTLEPLKKLDSLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DQE--DK------------ D_rerio_ENSDARP00000033105 ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDHLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DLD--DR------------ O_cuniculus_ENSOCUP00000005024 ELS-------DNRI--YGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDCLKSLDL------FNCE-VTNLNDYRESVFRLLPQLTYLDGY------DRE--DR------------ A_carolinensis_ENSACAP00000007900 ELS-------DNLI--SGGLEVLAERCPNLTYLNLSGNKIKDLSTVESLQNLKNLKSLDL------FNCE-ITKPKDYRESVFELLQQITYLDGF------DQD--DN------------ M_mulatta_ENSMMUP00000016055 ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ H_sapiens_ENSP00000345848 ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ P_pygmaeus_ENSPPYP00000021773 ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ P_troglodytes_ENSPTRP00000036180 ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ D_rerio_ENSDARP00000071527 ELS-------DNNI--SGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDL------FNCE-ITTLEDYRESIFELLPQVTYLDGF------DAE--DN------------ T_rubripes_ENSTRUP00000019528 ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL------FNCE-VTNLGDYRESIFKLLPQLTYLDGY------DID--DC------------ O_anatinus_ENSOANP00000017079 ELS-------DNRI--FGGLDVLAERLPNLTHLNLSGNKLKDISTLEPLKKLVFLKSLDL------FNCE-VTNLNDYRENVFSLLPQLTYLDGY------DRD--DR------------ G_aculeatus_ENSGACP00000024521 ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL------FNCE-VTNLADYRESIFKLLPQLTYLDGY------DID--DC------------ B_taurus_ENSBTAP00000028486 ELS-------DNRI--CGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DR------------ O_anatinus_ENSOANP00000020934 ELS-------DNRI--CGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLRSLDL------FNCE-VTMLINYRESMFGLLPQLTYLDGF------DAD--DQ------------ X_tropicalis_ENSXETP00000034315 ELS-------DNSI--SGGLDVLTERCPNITYLNLSGNKIKDLSTVESLANLKNLKSLDL------FNCE-ITNLEDYRENIFQRLSQITYLDGF------DQE--DN------------ R_norvegicus_ENSRNOP00000043155 ELS-------ENRI--SGDLEVLAEKCLNLKHLNLSGNKIKDPSAIEPLRKLENLKSLDL------FKCE-VTNLTAYQENEFKLLPEVMCLDGY------DRD--NK------------ O_cuniculus_ENSOCUP00000000076 ELS-------DNRI--SGGLDVLAEKCPTLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL------FNCE-MTNLNDYRENVFELLPQLTYLDSY------DRD--DK------------ G_aculeatus_ENSGACP00000022955 ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDNLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DTE--DR------------ O_latipes_ENSORLP00000025080 ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL------FNCE-VTNLADYRDSIFKLLPQLTYLDGY------DVN--DR------------ O_latipes_ENSORLP00000001658 ELS-------DNNL--SGSLETLAEKCPNLTYLNLSGNKIKELSTLEALQNLKSLQSLDL------FNCE-ITSLEDYRESVFELLPQVTYLDGF------DQE--DN------------ M_domestica_ENSMODP00000004440 ELS-------DNLI--SGGLEVL-ERTPSLVQLNLSRNKIKDINTLEPLKKLPNLKSLDL------FNCD-VTMLMSYRESVFGLLPQLTYLDGY------SAD--DK------------ E_caballus_ENSECAP00000006868 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ T_rubripes_ENSTRUP00000027152 ELS-------DNRI--SSGLDVLAEKLPNLRHLNLSGNKLKDMSTLEPLKKLENLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DIE--DR------------ G_gorilla_ENSGGOP00000011344 ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ G_gallus_ENSGALP00000040136 ELS-------DNII--SGGLEVLAERCPNLTYLNLSGNKIKDLGTVEALQNLKNLKSLDL------FNCE-ITNLEDYRDSIFDLLQQITYLDGF------DQE--DN------------ C_familiaris_ENSCAFP00000003588 ELS-------DNRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLEYLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DR------------ R_norvegicus_ENSRNOP00000028744 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ M_musculus_ENSMUSP00000015893 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ O_cuniculus_ENSOCUP00000005451 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRGSIFELLQQITYLDGF------DQE--DN------------ M_musculus_ENSMUSP00000083521 ELS-------ENRI--FGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDL------FGCE-VTNRSDYRETVFRLLPQLSYLDGY------DRE--DQEAPDSDVEVDSV X_tropicalis_ENSXETP00000021012 ELS-------DNRI--SGGLEVLAERTPNLTHLNLSGNKIKEINTLEPLKKLPHLMSLDL------FNCE-VTMLNNYRESVFELLPQLTFLDGF------DAD--DQ------------ G_aculeatus_ENSGACP00000013165 ELS-------DNNL--CGSLGTLSEKCPNLTYLNLSGNKIKELSNVEALQNLKSLQSLDL------FNCD-ITSLEDYRDSVFELLPQVTYLDGF------DQE--DN------------ C_familiaris_ENSCAFP00000017286 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ H_sapiens_ENSP00000324074 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ P_troglodytes_ENSPTRP00000051813 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ B_taurus_ENSBTAP00000022237 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ T_rubripes_ENSTRUP00000010444 DLS-------YNNL--SGSLEKLTEKCPNLTHLNLSGNKIQDLTHLETLQNLKNLRSLEL------LNCD-ITSVADYRDGVFQLLPQVTYLDGF------DCD--DN------------ O_latipes_ENSORLP00000025809 EVS-------ENSI--GGGLNTLVEKCPGLTHLNLSSNKLKELSSLEPLQSLKALKSLDL------YGCD-VSSLDDYRERVFQLLPQLTYLDGF------DQE--DN------------ G_gorilla_ENSGGOP00000011594 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGSKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ P_pygmaeus_ENSPPYP00000005091 ELS-------SNRA--SGGLEVLAEKCPNLIHLNLSGNKIKDLSTIEPLKKLENLESLDL------FNCE-VTNLNDY------------------------------------------ G_aculeatus_ENSGACP00000004164 EVS-------DNTI--TGNLEALAETCPNLAYLNLSGNKIKELSSIEPLKSLKNLKSLYL------YSCE-VSTLDDYTDAVFELLPQLTFLDGY------DHE--DN------------ T_rubripes_ENSTRUP00000020657 EVS-------DNII--AGGLDTLAEKCPNLTYLNLSGNKIKELKTLKVLQNLKNLRSLDL------YSCE-VSTLEDYRESVFELLPQLTYLDGF------DQE--DN------------ T_nigroviridis_ENSTNIP00000008152 ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL------FNCE-VTNLGDYRDSIFKLLPQLTYLRGC------ERGLLQR------------ M_domestica_ENSMODP00000023408 ELS-------DNFI--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKSLKSLDL------FNCE-ITHLQDYRESIFELLQQITYLDGY------DQE--DN------------ T_guttata_ENSTGUP00000004677 ELS-------DNVI--SGGLEVLAERCPNLTYLNLSGNKIKDLGTVEALQNLKNLKSLDL------FNCE-ITNLEDYRDSIFELLQQITYLDGF------DQE--DN------------ P_pygmaeus_ENSPPYP00000007165 ELS-------DNRV--SGGVEVLAEKCPNLMHLNLSGNKIKDLSTTEPLKKLENLKTLDL------FNCE-VTNLNDY------------------------------------------ H_sapiens_ENSP00000266594 ELS-------SNRA--SVGLEVLAEKCPNLIHLNLSGNKIKDLSTIEPLKKLENLESLDL------FTCE-VTNLNNY------------------------------------------ E_caballus_ENSECAP00000010263 ELS-------DNRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDCLKSLDL------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ T_guttata_ENSTGUP00000000363 ELS-------DNRI--SGGLEVLAEKTPNLTHLNLSGNKIKDINTLEPLQHLPNLRSLDL------STAR-WTMLINYRESVFALLPQLTY-DGF------DAK--KQ------------ T_nigroviridis_ENSTNIP00000005512 EVS-------DNVI--AGGLDALSEKCPNLTYLNLSGNKIKELDVLKVLQNLKNLKSLDL------YSCE-VSTLEDYRDSVFELLPQLTYLDGF------DQE--DN------------ R_norvegicus_ENSRNOP00000056793 ELS-------ENRI--FGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDL------FGCE-VTNRSDYRETVFRLLPQLSYLDGY------DRE--DQEAPDSDVEVDSV T_nigroviridis_ENSTNIP00000007469 DLS-------YNNL--SASLDKLAEKCPNLTHLNLSGNKIKELTHLETLQNLKNLRSLEL------LNCD-VTAVAGYRDGVFRLLPHVTYLDGF------DCD--DN------------ O_cuniculus_ENSOCUP00000008041 ELN-------DNII--SGGLEVLAEKCRNLTYLNLSGNKIKDLSTVEALQNLKNFKSLDL------FNCE-ITNLEDYRGSIFALLQQIMYLDWF------DQE--DN------------ M_mulatta_ENSMMUP00000016400 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ O_cuniculus_ENSOCUP00000011938 KLS-------DNII--SGGLEDLAEKCPNLTYLSLSGNKI--LSTVEALQNLKNLKS--L------FNCE-ITNLEDYRRSIFELLQQITYLVGF------DQG--DN------------ O_anatinus_ENSOANP00000006726 ELS-------DNII--SGGLEVLAEKCPNLTYLNL-GNKIKDLSTVEALQNLKSLKSLDL------FNCE-ITNLEDYRESVFELLQQITYLDGF------DQE--DN------------ M_domestica_ENSMODP00000019786 -------------------LEVLAEQTPSPVQLNLSRNKIKD--TLEPLKKLPHLKSLDP------FNCD-VTMLMSYRESAFGLLSQLTYLDGY------STN--EK------------ O_cuniculus_ENSOCUP00000003696 ELS-------DNII--SRGLGALEEKSPNFIYINLSGNKIKDLSTVEALQNLKNFKTLDL------FNCE-ITNLEDYRGSIFKLLQQITYLDGF------DQE--DN------------ C_intestinalis_ENSCINP00000018746 ELS-------DNRI--SGSLACL-KGCTSLTHLNLSGNKIKTIEALQPLSELPLLTLLDL------FNCE-VTKFPRYRENVFALLPNLKYLDGF------DAN--DT------------ A_gambiae_AGAP005075-PB ELS-------DNRI--SNGLNHLT-GSPKLTHLNLSGNRIKDFDELQPLKDLENLEVLDL------FNNQ-VTLIENYREKLFQLIPSLNYLDGF------DKE--YV------------ A_aegypti_AAEL001605-PA ELS-------DNRI--QNALSHLT-GSPKLTHLNLSGNRIKDFEELQPLKELENLEVLDL------FNNE-VTMTQNYRDKIFELIPSLKYLDGF------DRE--DA------------ D_melanogaster_FBpp0112004 ELS-------DNRI--SSGLNYLT-TSPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDL------FNND-ATQVDNYREKIFKMLPSLNFLDGF------DCN--DE------------ G_gorilla_ENSGGOP00000000179 ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ P_pygmaeus_ENSPPYP00000013309 WLP-------DNRD--FGDLDML-----KLTYLNLDGNTLKDIRTLEPLKKLEHPKSLDL------LNSE-VTSLNEDWESVFKLLPQLTYLDHY------DQE--DQ------------ P_pygmaeus_ENSPPYP00000001060 -------------------------------------------------QNLKNLKSLDL------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ C_elegans_F33H2.3 DIS-------DNQLGDNASFDVLVKNAPDLKKITLASNKL-SLDNLRCLKVLPNLFELDL------SNNPSLGLLEDYREKMFEMIPSLKILDGC------DVD--GE------------ C_elegans_T19H12.2 DLS-------DNELGDDASFDVLIKCAPEIKKITLSGNRL-TLDNVRTLKMLPNLMELDL------SNNSSLGLLDDYRVKMFEMIPSLKILDGC------DVD--GE------------ A_aegypti_AAEL012656-PD LLN-------NNRI--VRVSDTLHESLPNLESVVLTGNNVQELGDLEPLTKLPKLQSLSL------LTNP-VSTKQYYREYVAFRFPNLRLLDFR------KIK--LK------------ A_gambiae_AGAP007670-PB LLN-------NNRI--VRIGENLHESLPNLQSIILTGNNIQELGDLEPLTKLPNLETLSL------LTNP-VSTKQHYREYVAFRFPNLRLLDFR------KIR--QK------------ A_aegypti_AAEL006840-PA LLN-------NNRI--VRVSDTLHESLPNLESVVLTGNNVQELGDLEPLTKLPKLQSLSL------LTNP-VSTKQYYREYVAFRFPNLRLLDFR------KIK--LK------------ D_melanogaster_FBpp0088015 LLN-------NNRI--LRISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKLETICL------LINP-VSTKPNYREYMAYKFPQLRLLDFR------KIK--QK------------ T_nigroviridis_ENSTNIP00000009472 LMN-------SNRI--CRIGENLEQSLPNLRELVLTSNNIQELGDLDPLATVKTLSLLSL------LRNP-VTNKKHYRLYVINKLPQLHVLDFQ------KVK--LK------------ T_rubripes_ENSTRUP00000000150 LMN-------SNRI--CRIGENLEQALPNLRELILTSNNIQELGDLDPLATIKTLSLLSL------LRNP-VTNKKHYRLYVINKLPQLRVLDFQ------KVK--LK------------ G_gallus_ENSGALP00000011598 LMN-------NNRI--CRIGEGLEQALPSLTELVLTNNNISELGELDPLSSIKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ A_carolinensis_ENSACAP00000003100 LMN-------NNRL--SRIGEGLEQSLPNLKELILTNNNIMELGDLDPLATIKSLTYLSL------LRNP-VTNKKHYRLYVIYKAPQVRVLDFQ------KVK--LK------------ C_elegans_F43G6.3 DLS-------DNELGDDASFDVLISSAPKLKRLTLSGNPL-SLEKVRTLRMLPYLQELDL------TNIQALGAFDDYRSVVFEMIPSLIILNGV------TIV--GE------------ T_guttata_ENSTGUP00000009232 LMN-------NNRI--CRIGENLEQALPSLTELILTNNNIAELGELDPLSSIKSLTYLSV------LRNP-VTNKKHYRLYLIHKVPQVRVLDFQ------KVK--LK------------ C_intestinalis_ENSCINP00000011422 DLS-------GNNLFSLCGLEGMN----DLCLLNCEGNQLSDLAEIQYIESIQSIRTLNF------VNNP-MVEAEEYRKSVIFAMQQITELDGV------PVS--VE------------ P_pygmaeus_ENSPPYP00000021193 NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLQHNIHLKELFL------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ T_rubripes_ENSTRUP00000025664 NLA-------DNKI--EKIGQSL-DPNTNLQNLNLSGNKISSIKDLTKLAHLPQLRELMLNDPT-TTPNP-VCLLHNYATHVLYHMPQLQHLDTH------DIS--ST------------ M_mulatta_ENSMMUP00000020530 NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLKHNIHLKELFL------MGNP-CAFFDHYREFVVATLPQLKWLDGK------EIE--PS------------ B_taurus_ENSBTAP00000018076 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ E_caballus_ENSECAP00000017313 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ O_anatinus_ENSOANP00000018632 LVN-------NNRI--CRVGEGLDQALPSLRELILTNNSILELGDLDPLATLKSLTYLSI------LRNP-VTNKKHYRLYVIHKVPQVRVLDFQ------KVK--LK------------ M_domestica_ENSMODP00000015061 LVN-------NNRI--CRIGEGLDQALPSLRELILTNNSIVELGDLDPLATLKSLTYLSI------LRNP-VTNKKHYRLYVIHKVPQVRVLDFQ------KVK--LK------------ G_aculeatus_ENSGACP00000013527 GLS-------ANRI---SNLDPL-RSCDSLQHLNLAGNIISSIESLHCLQPLRKLENIRLKDNTYNYSNP-VCRNSAYRNTVLEMFPNIKVLDGE------RVVGRGS------------ M_musculus_ENSMUSP00000032723 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ R_norvegicus_ENSRNOP00000016758 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ C_familiaris_ENSCAFP00000015542 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ H_sapiens_ENSP00000254193 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ M_mulatta_ENSMMUP00000015518 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ P_pygmaeus_ENSPPYP00000007744 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ P_troglodytes_ENSPTRP00000041754 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ H_sapiens_ENSP00000250173 NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ P_troglodytes_ENSPTRP00000035210 NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLQHNIHLKELFL------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ R_norvegicus_ENSRNOP00000037753 DLSMLIVFFLDSLI--AWWESLLLLLAYALYVFTMKWNKQIERWVKEQLSRRPVAKVMAL------------GDLSKVRHEVLEHRGGAQGEEGTRDDYIERKK--DE------------ E_caballus_ENSECAP00000002990 NLA-------LNNI---EKVENL-EGCEGLTKLDLTINFIGELSSIKTLRHNIHLKELFL------MGNP-CADFDGYRQFVVATLQQLKWLDGK------EIE--RS------------ G_gorilla_ENSGGOP00000008764 LVN-------NNRI--CRIGEGLDQALPCLTELILTNNRLVELGDLDPLASLKSLTYLSI------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KMK--LK------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- G_aculeatus_ENSGACP00000022373 -EAP-----------------------------D--SDAE--VYA----------------E---------------------------------------------------------- C_familiaris_ENSCAFP00000025783 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 -EAP-----------------------------D--SDAE---YV----------------E---------------------------------------------------------- A_carolinensis_ENSACAP00000013586 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- G_gallus_ENSGALP00000013053 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- D_rerio_ENSDARP00000022360 -EAP-----------------------------D--SDAE--AYV----------------E---------------------------------------------------------- X_tropicalis_ENSXETP00000017086 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- M_domestica_ENSMODP00000034651 -EAP-----------------------------D--SDVE--AYV----------------E---------------------------------------------------------- H_sapiens_ENSP00000329250 -EAP-----------------------------Y--SDIE--DHV----------------E---------------------------------------------------------- T_guttata_ENSTGUP00000010000 -EAPDSDAEGYVEELDDKEEDEDVKDRDDKEAPD--SDAE--GYV----------------E---------------------------------------------------------- O_anatinus_ENSOANP00000021355 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- B_taurus_ENSBTAP00000016410 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- E_caballus_ENSECAP00000002350 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 -EAP-----------------------------D--SDAE--VYA----------------E---------------------------------------------------------- M_mulatta_ENSMMUP00000029913 -EAP-----------------------------D--SDAE--GYV----------------E---------------------------------------------------------- M_musculus_ENSMUSP00000082652 -EAP-----------------------------D--SDVE--GYV----------------E---------------------------------------------------------- G_gorilla_ENSGGOP00000015042 -EAP--------------------------------SDAE--GYV----------------E---------------------------------------------------------- T_rubripes_ENSTRUP00000042944 -EAP-----------------------------D--SDSE--VYA----------------E---------------------------------------------------------- M_domestica_ENSMODP00000003980 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- O_latipes_ENSORLP00000002331 -EAP-----------------------------D--SDGE--VYA----------------E---------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 -EAS-----------------------------D--SDGE--VDG----------------D---------------------------------------------------------- G_gallus_ENSGALP00000002398 -EAP-----------------------------D--SDPE--ADG----------------D---------------------------------------------------------- X_tropicalis_ENSXETP00000022463 -EAP-----------------------------D--SDAE--ADG----------------D---------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 -EAP-----------------------------D--SDVE--GYV----------------E---------------------------------------------------------- O_latipes_ENSORLP00000008884 -EAS-----------------------------D--SDGE--V------------------D---------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 -EAP-----------------------------D--SDIK--GYV----------------E---------------------------------------------------------- A_carolinensis_ENSACAP00000004238 -EAS-----------------------------D--SDAE--V------------------D---------------------------------------------------------- D_rerio_ENSDARP00000033105 -EAS-----------------------------D--SDGE--V------------------D---------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- A_carolinensis_ENSACAP00000007900 -EAP-----------------------------D--SEDE--DDE----------------D---------------------------------------------------------- M_mulatta_ENSMMUP00000016055 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- H_sapiens_ENSP00000345848 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- D_rerio_ENSDARP00000071527 -EAP-----------------------------D--SEAD--DDD--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 -EAS-----------------------------D--SDGE--G------------------D---------------------------------------------------------- O_anatinus_ENSOANP00000017079 -EAQ-----------------------------K--RRED--RGT----------------E---------------------------------------------------------- G_aculeatus_ENSGACP00000024521 -EAS-----------------------------D--S----------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028486 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- O_anatinus_ENSOANP00000020934 -EAP-----------------------------D--SDPE--VDG----------------E---------------------------------------------------------- X_tropicalis_ENSXETP00000034315 -EAP-----------------------------D--SEED--DDD----------------D---------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 -EAP-----------------------------D--SDVE--GYV----------------E---------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 -EAS-----------------------------D--SDAE--SYV----------------E---------------------------------------------------------- G_aculeatus_ENSGACP00000022955 -EAS-----------------------------D--SDGE--V------------------D---------------------------------------------------------- O_latipes_ENSORLP00000025080 -EAS-----------------------------D--SEGE--G------------------D---------------------------------------------------------- O_latipes_ENSORLP00000001658 -EAP-----------------------------D--SEAD--DED--------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 -EAP-----------------------------D--SDPE--ADR----------------E---------------------------------------------------------- E_caballus_ENSECAP00000006868 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- T_rubripes_ENSTRUP00000027152 -EAS-----------------------------D--SDGE--VDG----------------D---------------------------------------------------------- G_gorilla_ENSGGOP00000011344 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- G_gallus_ENSGALP00000040136 -EAP-----------------------------D--SEDD--DDE--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 -EAP-----------------------------D--SEEE-EEDE----------------D---------------------------------------------------------- M_musculus_ENSMUSP00000015893 -EAP-----------------------------D--SEEEDDDDE----------------D---------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- M_musculus_ENSMUSP00000083521 EEAP-----------------------------D--SDGE--V------------------D---------------------------------------------------------- X_tropicalis_ENSXETP00000021012 -EAP-----------------------------D--SDPE--AED----------------L---------------------------------------------------------- G_aculeatus_ENSGACP00000013165 -EAP-----------------------------D--SEAD--DEE--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- H_sapiens_ENSP00000324074 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- B_taurus_ENSBTAP00000022237 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- T_rubripes_ENSTRUP00000010444 -EAS-----------------------------N--SDDD--DDAYE--------------D---------------------------------------------------------- O_latipes_ENSORLP00000025809 -EAS-----------------------------D--NGEA--PSV----------------T---------------------------------------------------------- G_gorilla_ENSGGOP00000011594 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 -EAP-----------------------------D--SEAD--TDD--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 -EVP-----------------------------D--SEAD--GDGE------CLGMTATSHN---------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 -ESP-----------------------------S--EDED--GEV----------------N---------------------------------------------------------- M_domestica_ENSMODP00000023408 -EAP-----------------------------D--SEEE--EDDDE--------------E---------------------------------------------------------- T_guttata_ENSTGUP00000004677 -EAP-----------------------------D--SEDD--DDE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 -EAP-----------------------------D--SDAE--V------------------D---------------------------------------------------------- T_guttata_ENSTGUP00000000363 -KPH-----------------------------T--QTPE--TEG----------------M---------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 -EVP-----------------------------D--SEPD--GDGEATPPPQCLARRGPA------------------------------------------------------------ R_norvegicus_ENSRNOP00000056793 EEAP-----------------------------D--SDGE--V------------------D---------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 -EAS-----------------------------N--SDDD-------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 -EAP-----------------------------D--PEEE--DDE----------------D---------------------------------------------------------- M_mulatta_ENSMMUP00000016400 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 -EAP-----------------------------D--SEEE--DEE----------------D---------------------------------------------------------- O_anatinus_ENSOANP00000006726 -EAP-----------------------------D--SEEE--DDDG------R--------C---------------------------------------------------------- M_domestica_ENSMODP00000019786 -EAP-----------------------------D--SDPE--ADR----------------E---------------------------------------------------------- O_cuniculus_ENSOCUP00000003696 -KAQ-----------------------------D--SKED--DDEX------XXXXXXXXXX---------------------------------------------------------- C_intestinalis_ENSCINP00000018746 -EAV-----------------------------D--SDDE---------------------E---------------------------------------------------------- A_gambiae_AGAP005075-PB -EAP-----------------------------S--DEED--MAE----------------E---------------------------------------------------------- A_aegypti_AAEL001605-PA -EAP-----------------------------S--DEDD--EAN----------------G---------------------------------------------------------- D_melanogaster_FBpp0112004 -EVQ-----------------------------SDGDDDD--EVN----------------G---------------------------------------------------------- G_gorilla_ENSGGOP00000000179 -EAP-----------------------------D--SEEE--DDE--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013309 -EAH-----------------------------N--SDVE--G------------------D---------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 -EAP-----------------------------D--SEEE--DDE----------------D---------------------------------------------------------- C_elegans_F33H2.3 -EVE-----------------------------E-------------------------------------------------------------------------------------- C_elegans_T19H12.2 -EVE-----------------------------E-------------------------------------------------------------------------------------- A_aegypti_AAEL012656-PD -ERE-----------------------------A--AKELFKSK-----------------K---------------------------------------------------------- A_gambiae_AGAP007670-PB -ERE-----------------------------A--ANLLFKSK-----------------K---------------------------------------------------------- A_aegypti_AAEL006840-PA -ERE-----------------------------A--AKELFKSK-----------------K---------------------------------------------------------- D_melanogaster_FBpp0088015 -DRQ-----------------------------A--AQEFFRTK-----------------Q---------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 -ERL-----------------------------E--AEKMFRGK-----------------R---------------------------------------------------------- T_rubripes_ENSTRUP00000000150 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- G_gallus_ENSGALP00000011598 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- A_carolinensis_ENSACAP00000003100 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- C_elegans_F43G6.3 -DV--------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000009232 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- C_intestinalis_ENSCINP00000011422 -EKVMA-----------------------VNLFDPPPEVQAALDHITHTVYRFLQPSKIYESTLPSIEMPYPMLVLTGPQASGKRELAHRLAQEFPDYFGFGVSHTTRVMHPGETNGKEY P_pygmaeus_ENSPPYP00000021193 -ERI-----------------------------K--ALQDYSVIE--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 -EVK-----------------------------D--TAESIVMKKMMYYNMRVQTAQRKLRETRLSLLERKKIMLEPPEESLTRINHCLKSLEHELSKVSSACEMKDGTVEDSVQSRDPT M_mulatta_ENSMMUP00000020530 -ERI-----------------------------K--ALQEYSIIE--------------------------------------------------------------------------- B_taurus_ENSBTAP00000018076 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- E_caballus_ENSECAP00000017313 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- O_anatinus_ENSOANP00000018632 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- M_domestica_ENSMODP00000015061 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- G_aculeatus_ENSGACP00000013527 -DLY-----------------------------QLCKDIDDTIKA--------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- C_familiaris_ENSCAFP00000015542 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- H_sapiens_ENSP00000254193 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- M_mulatta_ENSMMUP00000015518 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- H_sapiens_ENSP00000250173 -ERI-----------------------------K--ALQDYSVIE--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 -ERI-----------------------------K--ALQDYSVIE--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 -EGETE-----------------------AERKEHGQEEETETKGKEKQEGETESEGKDEQE---------------------------------------------------------- E_caballus_ENSECAP00000002990 -ERI-----------------------------Q--ALQNFPVIE--------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 -ERQ-----------------------------E--AEKMFKGK-----------------R---------------------------------------------------------- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ---------------------------------------------------------------------------------------------------GLDD----------------- P_pygmaeus_ENSPPYP00000007477 ---------------------------------------------------------------------------------------------------GLDD----------------- G_aculeatus_ENSGACP00000022373 ---------------------------------------------------------------------------------------------------GLDD----------------- C_familiaris_ENSCAFP00000025783 ---------------------------------------------------------------------------------------------------GLDD----------------- P_troglodytes_ENSPTRP00000039448 ---------------------------------------------------------------------------------------------------GLDD----------------- A_carolinensis_ENSACAP00000013586 ---------------------------------------------------------------------------------------------------GLDD----------------- G_gallus_ENSGALP00000013053 ---------------------------------------------------------------------------------------------------GLDD----------------- D_rerio_ENSDARP00000022360 ---------------------------------------------------------------------------------------------------GLDD----------------- X_tropicalis_ENSXETP00000017086 ---------------------------------------------------------------------------------------------------GLDD----------------- M_domestica_ENSMODP00000034651 ---------------------------------------------------------------------------------------------------GLED----------------- H_sapiens_ENSP00000329250 ---------------------------------------------------------------------------------------------------GLDD----------------- T_guttata_ENSTGUP00000010000 ---------------------------------------------------------------------------------------------------GLDD----------------- O_anatinus_ENSOANP00000021355 ---------------------------------------------------------------------------------------------------GLDD----------------- B_taurus_ENSBTAP00000016410 ---------------------------------------------------------------------------------------------------GLDD----------------- E_caballus_ENSECAP00000002350 ---------------------------------------------------------------------------------------------------GLDD----------------- T_nigroviridis_ENSTNIP00000012431 ---------------------------------------------------------------------------------------------------GLDD----------------- M_mulatta_ENSMMUP00000029913 ---------------------------------------------------------------------------------------------------GLDD----------------- M_musculus_ENSMUSP00000082652 -----------------------------------------------------------------------------------------------------DD----------------- G_gorilla_ENSGGOP00000015042 ---------------------------------------------------------------------------------------------------GLDD----------------- T_rubripes_ENSTRUP00000042944 ---------------------------------------------------------------------------------------------------GLDD----------------- M_domestica_ENSMODP00000003980 ---------------------------------------------------------------------------------------------------GVDD----------------- O_latipes_ENSORLP00000002331 ---------------------------------------------------------------------------------------------------GLDD----------------- T_nigroviridis_ENSTNIP00000013976 ---------------------------------------------------------------------------------------------------GIYD----------------- G_gallus_ENSGALP00000002398 ---------------------------------------------------------------------------------------------------GLED----------------- X_tropicalis_ENSXETP00000022463 ---------------------------------------------------------------------------------------------------GVDE----------------- R_norvegicus_ENSRNOP00000020443 -----------------------------------------------------------------------------------------------------DD----------------- O_latipes_ENSORLP00000008884 ---------------------------------------------------------------------------------------------------GVDD----------------- P_troglodytes_ENSPTRP00000028434 ---------------------------------------------------------------------------------------------------GLDD----------------- A_carolinensis_ENSACAP00000004238 ---------------------------------------------------------------------------------------------------GVDE----------------- D_rerio_ENSDARP00000033105 ---------------------------------------------------------------------------------------------------GVDD----------------- O_cuniculus_ENSOCUP00000005024 ---------------------------------------------------------------------------------------------------GVDE----------------- A_carolinensis_ENSACAP00000007900 ---------------------------------------------------------------------------------------------------GDED----------------- M_mulatta_ENSMMUP00000016055 ---------------------------------------------------------------------------------------------------GVDE----------------- H_sapiens_ENSP00000345848 ---------------------------------------------------------------------------------------------------GVDE----------------- P_pygmaeus_ENSPPYP00000021773 ---------------------------------------------------------------------------------------------------GVDE----------------- P_troglodytes_ENSPTRP00000036180 ---------------------------------------------------------------------------------------------------GVDE----------------- D_rerio_ENSDARP00000071527 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019528 ---------------------------------------------------------------------------------------------------IVDD----------------- O_anatinus_ENSOANP00000017079 ---------------------------------------------------------------------------------------------------GIKN----------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ---------------------------------------------------------------------------------------------------GVDE----------------- O_anatinus_ENSOANP00000020934 ---------------------------------------------------------------------------------------------------GLDD----------------- X_tropicalis_ENSXETP00000034315 ---------------------------------------------------------------------------------------------------EYEY----------------- R_norvegicus_ENSRNOP00000043155 ---------------------------------------------------------------------------------------------------DEDN----------------- O_cuniculus_ENSOCUP00000000076 ---------------------------------------------------------------------------------------------------SLDD----------------- G_aculeatus_ENSGACP00000022955 ---------------------------------------------------------------------------------------------------GVDD----------------- O_latipes_ENSORLP00000025080 ---------------------------------------------------------------------------------------------------GVDD----------------- O_latipes_ENSORLP00000001658 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004440 ---------------------------------------------------------------------------------------------------GLDK----------------- E_caballus_ENSECAP00000006868 ---------------------------------------------------------------------------------------------------GDED----------------- T_rubripes_ENSTRUP00000027152 ---------------------------------------------------------------------------------------------------GTDD----------------- G_gorilla_ENSGGOP00000011344 ---------------------------------------------------------------------------------------------------GVDE----------------- G_gallus_ENSGALP00000040136 ---------------------------------------------------------------------------------------------------GDED----------------- C_familiaris_ENSCAFP00000003588 ---------------------------------------------------------------------------------------------------GVDE----------------- R_norvegicus_ENSRNOP00000028744 ---------------------------------------------------------------------------------------------------GDED----------------- M_musculus_ENSMUSP00000015893 ---------------------------------------------------------------------------------------------------GDED----------------- O_cuniculus_ENSOCUP00000005451 ---------------------------------------------------------------------------------------------------GDED----------------- M_musculus_ENSMUSP00000083521 ---------------------------------------------------------------------------------------------------GVDK----------------- X_tropicalis_ENSXETP00000021012 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013165 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017286 ---------------------------------------------------------------------------------------------------GDED----------------- H_sapiens_ENSP00000324074 ---------------------------------------------------------------------------------------------------GDED----------------- P_troglodytes_ENSPTRP00000051813 ---------------------------------------------------------------------------------------------------GDED----------------- B_taurus_ENSBTAP00000022237 ---------------------------------------------------------------------------------------------------GDED----------------- T_rubripes_ENSTRUP00000010444 ---------------------------------------------------------------------------------------------------WFCV----------------- O_latipes_ENSORLP00000025809 ---------------------------------------------------------------------------------------------------HTGS----------------- G_gorilla_ENSGGOP00000011594 ---------------------------------------------------------------------------------------------------GDED----------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020657 ---------------------------------------------------------------------------------------------------RQFV----------------- T_nigroviridis_ENSTNIP00000008152 ---------------------------------------------------------------------------------------------------GDLD----------------- M_domestica_ENSMODP00000023408 ---------------------------------------------------------------------------------------------------GGDD----------------- T_guttata_ENSTGUP00000004677 ---------------------------------------------------------------------------------------------------GDED----------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ---------------------------------------------------------------------------------------------------GVDE----------------- T_guttata_ENSTGUP00000000363 ---------------------------------------------------------------------------------------------------PL------------------- T_nigroviridis_ENSTNIP00000005512 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056793 ---------------------------------------------------------------------------------------------------GVDK----------------- T_nigroviridis_ENSTNIP00000007469 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008041 ---------------------------------------------------------------------------------------------------GDED----------------- M_mulatta_ENSMMUP00000016400 ---------------------------------------------------------------------------------------------------GDED----------------- O_cuniculus_ENSOCUP00000011938 ---------------------------------------------------------------------------------------------------GDED----------------- O_anatinus_ENSOANP00000006726 ---------------------------------------------------------------------------------------------------GWAD----------------- M_domestica_ENSMODP00000019786 ---------------------------------------------------------------------------------------------------GLDT----------------- O_cuniculus_ENSOCUP00000003696 ---------------------------------------------------------------------------------------------------XXXX----------------- C_intestinalis_ENSCINP00000018746 ---------------------------------------------------------------------------------------------------GSGD----------------- A_gambiae_AGAP005075-PB ---------------------------------------------------------------------------------------------------EEPE-------DSCE------ A_aegypti_AAEL001605-PA ---------------------------------------------------------------------------------------------------GTGEEDYDSDLDPSS------ D_melanogaster_FBpp0112004 ---------------------------------------------------------------------------------------------------NDSDEVG----DKCNAFCLNG G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ---------------------------------------------------------------------------------------------------DVDD----------------- P_pygmaeus_ENSPPYP00000001060 ---------------------------------------------------------------------------------------------------GDED----------------- C_elegans_F33H2.3 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T19H12.2 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012656-PD ---------------------------------------------------------------------------------------------------GKEL----------------- A_gambiae_AGAP007670-PB ---------------------------------------------------------------------------------------------------GKEM----------------- A_aegypti_AAEL006840-PA ---------------------------------------------------------------------------------------------------GKEL----------------- D_melanogaster_FBpp0088015 ---------------------------------------------------------------------------------------------------GKDV----------------- T_nigroviridis_ENSTNIP00000009472 ---------------------------------------------------------------------------------------------------GAQL----------------- T_rubripes_ENSTRUP00000000150 ---------------------------------------------------------------------------------------------------GAQL----------------- G_gallus_ENSGALP00000011598 ---------------------------------------------------------------------------------------------------GAQL----------------- A_carolinensis_ENSACAP00000003100 ---------------------------------------------------------------------------------------------------GAQL----------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ---------------------------------------------------------------------------------------------------GAQL----------------- C_intestinalis_ENSCINP00000011422 HFVTPNHFQALLSQGYFVQTYRHSGCLY-----------------------------------------------------------------------GLSLDAIESVAKEGLACVVHM P_pygmaeus_ENSPPYP00000021193 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000025664 HPSPDPSIKQKIISKMEALKKRQAYWTRRLVEIDAWFKKNLAQAAHMTDYTVQFLLMELESVGNIRLEEGCPADRWFTSCCDLLLSRFRQLDFEVHSISGIKVNRVIRISNSALRLRFED M_mulatta_ENSMMUP00000020530 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018076 ---------------------------------------------------------------------------------------------------GAQL----------------- E_caballus_ENSECAP00000017313 ---------------------------------------------------------------------------------------------------GAQL----------------- O_anatinus_ENSOANP00000018632 ---------------------------------------------------------------------------------------------------GAQL----------------- M_domestica_ENSMODP00000015061 ---------------------------------------------------------------------------------------------------GAQL----------------- G_aculeatus_ENSGACP00000013527 ---------------------------------------------------------------------------------------------------GLYK----------------- M_musculus_ENSMUSP00000032723 ---------------------------------------------------------------------------------------------------GAQL----------------- R_norvegicus_ENSRNOP00000016758 ---------------------------------------------------------------------------------------------------GAQL----------------- C_familiaris_ENSCAFP00000015542 ---------------------------------------------------------------------------------------------------GAQL----------------- H_sapiens_ENSP00000254193 ---------------------------------------------------------------------------------------------------GAQL----------------- M_mulatta_ENSMMUP00000015518 ---------------------------------------------------------------------------------------------------GAQL----------------- P_pygmaeus_ENSPPYP00000007744 ---------------------------------------------------------------------------------------------------GAQL----------------- P_troglodytes_ENSPTRP00000041754 ---------------------------------------------------------------------------------------------------GAQL----------------- H_sapiens_ENSP00000250173 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035210 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000037753 ---------------------------------------------------------------------------------------------------GETE----------------- E_caballus_ENSECAP00000002990 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008764 ---------------------------------------------------------------------------------------------------GSQL----------------- 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ---------------------------EEEDED---------------EEEYDEDAQ--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 ---------------------------EEEDED---------------EEEYDEDAQ--------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 ---------------------------DEDD-----------------DEDGDEEEE--------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 ---------------------------DEEDED---------------EEEYDEDAQ--------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 ---------------------------EEEDED---------------EEEYDEDAQ--------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 ---------------------------EEDEED---------------GESFPKDAM--------------------------------------------------------------- G_gallus_ENSGALP00000013053 ---------------------------EEEDED---------------EEEYDDDAQ--------------------------------------------------------------- D_rerio_ENSDARP00000022360 ---------------------------EDDEED------------EGEEEDYDEDAA--------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 ---------------------------DDDEED---------------EDDYDEDAP--------------------------------------------------------------- M_domestica_ENSMODP00000034651 ---------------------------DEEDED---------------EEEYDEDAQ--------------------------------------------------------------- H_sapiens_ENSP00000329250 ---------------------------EEEGEH---------------EEEYDEDAQ--------------------------------------------------------------- T_guttata_ENSTGUP00000010000 ---------------------------EEEDED---------------EEEYDDDAQ--------------------------------------------------------------- O_anatinus_ENSOANP00000021355 ---------------------------DDEEDE---------------DGAYPADQ---------------------------------------------------------------- B_taurus_ENSBTAP00000016410 ---------------------------DEEDED---------------EEEYDEDAQ--------------------------------------------------------------- E_caballus_ENSECAP00000002350 ---------------------------DEEDED---------------EEEYDEDAQ--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 ---------------------------EDDDED---------------GKVENKELE--------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 ---------------------------EEEDED---------------EEEYDEDAQ--------------------------------------------------------------- M_musculus_ENSMUSP00000082652 ---------------------------DEEDED---------------EEEYDEYAQ--------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 ---------------------------EEEDED---------------XXXXXXXXX--------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 ---------------------------EDDDED--------------DEEEYDEDAA--------------------------------------------------------------- M_domestica_ENSMODP00000003980 ---------------------------EGEFEN---------Y-----NEEEDEEDE--------------------------------------------------------------- O_latipes_ENSORLP00000002331 ---------------------------DEDDEE--------------DEEEYDEDAP--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 ---------------------------DED------------------EEGEEEEDE--------------------------------------------------------------- G_gallus_ENSGALP00000002398 ---------------------------EYENGE--------------GEEEEDDDEE--------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 ---------------------------EEEDEE---------G-----EDEEEDEEE--------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 ---------------------------DEEDED---------------EEEYDEYAQ--------------------------------------------------------------- O_latipes_ENSORLP00000008884 ---------------------------DEDYFK---------KIYGCFTDGEEEEDE--------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 ---------------------------EEEGED---------------EEEYDEDAQ--------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 ---------------------------EDEEGE---------A-----SEEEEEEEE--------------------------------------------------------------- D_rerio_ENSDARP00000033105 ---------------------------DDD------------------EEGEDED----------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 ---------------------------EDEED----------------EDKAGPPGE--------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- H_sapiens_ENSP00000345848 ---------------------------EEEDEE---------G-----EDEEDEDDE--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- D_rerio_ENSDARP00000071527 ---------------------------DDEDG----------------DEGAGQLGE--------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 ---------------------------EDDEG----------------EREAPSGGR--------------------------------------------------------------- O_anatinus_ENSOANP00000017079 ---------------------------EGSGESG--------------FLQDKQNKE--------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ---------------------------EEDDEE---------G-----EDEDKEEDE--------------------------------------------------------------- O_anatinus_ENSOANP00000020934 ---------------------------EYDENGEG-------------EELWDECVG--------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 ---------------------------D---------------------DEEPGPRG--------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 ---------------------------EENE-----------------DEENDEYAQ--------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ---------------------------EEEDED--------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022955 ---------------------------DED------------------EEGEEEEDE--------------------------------------------------------------- O_latipes_ENSORLP00000025080 ---------------------------EGEEG----------------EEGGAKTQR--------------------------------------------------------------- O_latipes_ENSORLP00000001658 -----------------------------DEG----------------EEGAGPTGE--------------------------------------------------------------- M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 ---------------------------DEDEE----------------EDEAGPPEG--------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 ---------------------------DEDEGK---------D-----PEGEEEDDE--------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 ---------------------------EEEDEX---------X-----XXXXXXXXX--------------------------------------------------------------- G_gallus_ENSGALP00000040136 ---------------------------DNDED----------------EDEAGPPGE--------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 ---------------------------EEDEE----------------EDEAGPPEG--------------------------------------------------------------- M_musculus_ENSMUSP00000015893 ---------------------------EEDED----------------EDEAGPPEG--------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 ---------------------------D-DEE----------------EDEAGPPEG--------------------------------------------------------------- M_musculus_ENSMUSP00000083521 ---------------------------EEEDEE---------G-----EDEEEEEDE--------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 ------------------------------------------------EENGEDGED--------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 ------------------------------------------------EDGAAPAGD--------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 ---------------------------D-EEE----------------EDEAGPPEE--------------------------------------------------------------- H_sapiens_ENSP00000324074 ---------------------------DEEEE----------------ENEAGPPEG--------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 ---------------------------DEEEE----------------ENEAGPPEG--------------------------------------------------------------- B_taurus_ENSBTAP00000022237 ---------------------------DE-EE----------------EDEAGPPEG--------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 ---------------------------SADES----------------EEGAELPAG--------------------------------------------------------------- O_latipes_ENSORLP00000025809 ---------------------------F-LDE----------------EEEAGPPGD--------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 ---------------------------DEEEE----------------ENEAGPPEG--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------DDVAGPHGE--------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 ---------------------------PPFED----------------EDEAGPVGD--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 ---------------------------SEEDED---------------EEDEDEDEV--------------------------------------------------------------- M_domestica_ENSMODP00000023408 ---------------------------EEEEG------------------------R--------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ---------------------------D-DDD----------------ENEAGPPGE--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ---------------------------EEEDEE---------G-----EDEEDEEDE--------------------------------------------------------------- T_guttata_ENSTGUP00000000363 -------------------------------------------------KMKRDDEE--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 ------------------------------------------------EQTANVFTE--------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 ---------------------------EEEDEE---------G-----EDEEEEEDE--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 -----------------------------DES----------------EEGAGLPGG--------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 ---------------------------D-DEK----------------EDEAGPPEG--------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 ---------------------------DEEEE----------------ENEAGPPEG--------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 ---------------------------D-DEE----------------EDQAGPPEG--------------------------------------------------------------- O_anatinus_ENSOANP00000006726 ---------------------------PRGEG----------------EPEAGRQTR--------------------------------------------------------------- M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 ---------------------------XXXXX----------------XXXXXXXXX--------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 ---------------------------EEENGIDGNHVENG-------EEEDDEDDE--------------------------------------------------------------- A_gambiae_AGAP005075-PB ---------------------------ESDEEE------VSL--AYLYNDNLEEDQE--------------------------------------------------------------- A_aegypti_AAEL001605-PA ---------------------------DYDEEEDEDGNLVSL--ADVYNENLEEDGS--------------------------------------------------------------- D_melanogaster_FBpp0112004 LEIDLDELEAFEKRVKAKKSLQDKPPPQSEDKE------VDELDEYLKELQLRESTD--------------------------------------------------------------- G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ---------------------------KEEDEEG--------------ENEENEEDK--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 ---------------------------DEEEE----------------ENEAGPPEG--------------------------------------------------------------- C_elegans_F33H2.3 ------------------------------------------------EF-AGEGGE--------------------------------------------------------------- C_elegans_T19H12.2 ------------------------------------------------EFAAGEGAE--------------------------------------------------------------- A_aegypti_AAEL012656-PD ------------------------------------------------QREIMRKAK--------------------------------------------------------------- A_gambiae_AGAP007670-PB ------------------------------------------------HKEIVRKAK--------------------------------------------------------------- A_aegypti_AAEL006840-PA ------------------------------------------------QREIMRKAK--------------------------------------------------------------- D_melanogaster_FBpp0088015 ------------------------------------------------LKEISRKSK--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 ------------------------------------------------AKDIAKRTK--------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 ------------------------------------------------AKDIAKRTK--------------------------------------------------------------- G_gallus_ENSGALP00000011598 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 ------------------------------------------------AKDIARRAK--------------------------------------------------------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ------------------------------------------------AKDIARRAK--------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 EINGVRTLKNTYFEPRYVLILPVSKN-EHKARMIERGLYTKDQVKHISEKQTAMYAE--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 KFDSLRTSNDGSVQYNRCQLEHLFYLSDPEKDEKREILGIIEEGFQRVEEREASQGEGFIPFSNSLFLTEQPRIAHALTQACKADSECNIDPIPFRHSQVIVSKVFVGQSVPLVVGSPLD M_mulatta_ENSMMUP00000020530 ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--------------------------------------------------------------- B_taurus_ENSBTAP00000018076 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- E_caballus_ENSECAP00000017313 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- O_anatinus_ENSOANP00000018632 ------------------------------------------------AKDIARRTK--------------------------------------------------------------- M_domestica_ENSMODP00000015061 ------------------------------------------------AKDIARRTK--------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ------------------------------------------------NGQLVEHSD--------------------------------------------------------------- M_musculus_ENSMUSP00000032723 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- H_sapiens_ENSP00000254193 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- H_sapiens_ENSP00000250173 ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 --------------------------AEGKEADHEGETEAEGKEVEHEGETEAEGTE--------------------------------------------------------------- E_caballus_ENSECAP00000002990 ---------------------------QQIREQEKAYCLKRAKDKEEAQRKLQEDAD--------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 ------------------------------------------------AKDIARRSK--------------------------------------------------------------- 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007477 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022373 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000025783 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000039448 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013586 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013053 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000022360 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017086 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034651 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329250 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010000 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021355 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000016410 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002350 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012431 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000029913 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000082652 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015042 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042944 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000003980 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000002331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013976 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002398 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000022463 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020443 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008884 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000028434 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000004238 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000033105 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005024 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000007900 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016055 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000345848 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021773 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000036180 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071527 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000019528 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017079 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020934 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000034315 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000043155 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000025080 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001658 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027152 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011344 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000040136 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003588 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000028744 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000015893 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000005451 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000083521 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000021012 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013165 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017286 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000324074 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000051813 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000022237 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010444 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000025809 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000011594 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020657 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023408 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004677 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000363 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005512 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056793 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007469 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000008041 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016400 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011938 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000006726 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000018746 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005075-PB ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001605-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112004 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001060 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33H2.3 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T19H12.2 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012656-PD ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP007670-PB ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006840-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0088015 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009472 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000150 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000011598 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003100 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011422 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021193 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000025664 QNHYPNAYSVYQNVENRFRTGGREEGTCSSPTHSVPECSLGQRRWFVFDPELVLPEYIIFFEYVFEVRCKTELPDLSRHREGAPSGSSVLDGEVLNMEPVLKPQPKLLSLDNNLLLNVAR M_mulatta_ENSMMUP00000020530 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000018076 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017313 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000018632 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000015061 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013527 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000032723 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000016758 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015542 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000254193 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015518 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000007744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000041754 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000250173 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035210 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000037753 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000002990 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008764 ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -------------------------------------------------------------------------------------VVEDEE----------------------------- P_pygmaeus_ENSPPYP00000007477 -------------------------------------------------------------------------------------VVEDEE----------------------------- G_aculeatus_ENSGACP00000022373 -------------------------------------------------------------------------------------EGEDDD----------------------------- C_familiaris_ENSCAFP00000025783 -------------------------------------------------------------------------------------VVEDEE----------------------------- P_troglodytes_ENSPTRP00000039448 -------------------------------------------------------------------------------------VVEDEE----------------------------- A_carolinensis_ENSACAP00000013586 -------------------------------------------------------------------------------------NFDEED----------------------------- G_gallus_ENSGALP00000013053 -------------------------------------------------------------------------------------VVEDEE----------------------------- D_rerio_ENSDARP00000022360 -------------------------------------------------------------------------------------PGEEDE----------------------------- X_tropicalis_ENSXETP00000017086 -------------------------------------------------------------------------------------PGEEGE----------------------------- M_domestica_ENSMODP00000034651 -------------------------------------------------------------------------------------VVLPLE----------------------------- H_sapiens_ENSP00000329250 -------------------------------------------------------------------------------------VVEDEE----------------------------- T_guttata_ENSTGUP00000010000 -------------------------------------------------------------------------------------VVEDEE----------------------------- O_anatinus_ENSOANP00000021355 ---------------------------------------------------------------------------------------GDQT----------------------------- B_taurus_ENSBTAP00000016410 -------------------------------------------------------------------------------------VVEDEE----------------------------- E_caballus_ENSECAP00000002350 -------------------------------------------------------------------------------------VVEDEE----------------------------- T_nigroviridis_ENSTNIP00000012431 -------------------------------------------------------------------------------------LCADVD----------------------------- M_mulatta_ENSMMUP00000029913 -------------------------------------------------------------------------------------VVEDEE----------------------------- M_musculus_ENSMUSP00000082652 -------------------------------------------------------------------------------------LVEDEE----------------------------- G_gorilla_ENSGGOP00000015042 -------------------------------------------------------------------------------------XXXXXX----------------------------- T_rubripes_ENSTRUP00000042944 -------------------------------------------------------------------------------------PGDEEE----------------------------- M_domestica_ENSMODP00000003980 -------------------------------------------------------------------------------------D-EEDE-F--------------------------- O_latipes_ENSORLP00000002331 -------------------------------------------------------------------------------------PGEEEEDD--------------------------- T_nigroviridis_ENSTNIP00000013976 -------------------------------------------------------------------------------------DGEEED-F--------------------------- G_gallus_ENSGALP00000002398 -------------------------------------------------------------------------------------DDLDEE----------------------------- X_tropicalis_ENSXETP00000022463 -------------------------------------------------------------------------------------EGEEEEDV--------------------------- R_norvegicus_ENSRNOP00000020443 -------------------------------------------------------------------------------------LVEDEE----------------------------- O_latipes_ENSORLP00000008884 -------------------------------------------------------------------------------------DGEEED-F--------------------------- P_troglodytes_ENSPTRP00000028434 -------------------------------------------------------------------------------------VVEDEE----------------------------- A_carolinensis_ENSACAP00000004238 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- D_rerio_ENSDARP00000033105 ---------------------------------------------------------------------------------------EEED-F--------------------------- O_cuniculus_ENSOCUP00000005024 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- A_carolinensis_ENSACAP00000007900 -------------------------------------------------------------------------------------YEEN------------------------------- M_mulatta_ENSMMUP00000016055 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- H_sapiens_ENSP00000345848 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- P_pygmaeus_ENSPPYP00000021773 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- P_troglodytes_ENSPTRP00000036180 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- D_rerio_ENSDARP00000071527 -------------------------------------------------------------------------------------YEEE------------------------------- T_rubripes_ENSTRUP00000019528 -------------------------------------------------------------------------------------NGESED-F--------------------------- O_anatinus_ENSOANP00000017079 -------------------------------------------------------------------------------------AGKDGI----------------------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- O_anatinus_ENSOANP00000020934 -------------------------------------------------------------------------------------LMDSGF----------------------------- X_tropicalis_ENSXETP00000034315 -------------------------------------------------------------------------------------YEEEE------------------------------ R_norvegicus_ENSRNOP00000043155 -------------------------------------------------------------------------------------LVLEEE----------------------------- O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 -------------------------------------------------------------------------------------DGEEED-F--------------------------- O_latipes_ENSORLP00000025080 -------------------------------------------------------------------------------------SA--------------------------------- O_latipes_ENSORLP00000001658 -------------------------------------------------------------------------------------YDDE------------------------------- M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- T_rubripes_ENSTRUP00000027152 -------------------------------------------------------------------------------------DGEEED-F--------------------------- G_gorilla_ENSGGOP00000011344 -------------------------------------------------------------------------------------XXXXXX-X--------------------------- G_gallus_ENSGALP00000040136 -------------------------------------------------------------------------------------YEEE------------------------------- C_familiaris_ENSCAFP00000003588 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- R_norvegicus_ENSRNOP00000028744 -------------------------------------------------------------------------------------Y---------------------------------- M_musculus_ENSMUSP00000015893 -------------------------------------------------------------------------------------YEEE------------------------------- O_cuniculus_ENSOCUP00000005451 -------------------------------------------------------------------------------------FEEEEEEE--------------------------- M_musculus_ENSMUSP00000083521 -------------------------------------------------------------------------------------DGEEEE-D--------------------------- X_tropicalis_ENSXETP00000021012 -------------------------------------------------------------------------------------DEEDEE----------------------------- G_aculeatus_ENSGACP00000013165 -------------------------------------------------------------------------------------YD--------------------------------- C_familiaris_ENSCAFP00000017286 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- H_sapiens_ENSP00000324074 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- P_troglodytes_ENSPTRP00000051813 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- B_taurus_ENSBTAP00000022237 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- T_rubripes_ENSTRUP00000010444 -------------------------------------------------------------------------------------YHDEDD----------------------------- O_latipes_ENSORLP00000025809 -------------------------------------------------------------------------------------DDEE------------------------------- G_gorilla_ENSGGOP00000011594 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020657 -------------------------------------------------------------------------------------DDDD------------------------------- T_nigroviridis_ENSTNIP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023408 -------------------------------------------------------------------------------------VHNELLKL--------------------------- T_guttata_ENSTGUP00000004677 -------------------------------------------------------------------------------------YEEE------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 -------------------------------------------------------------------------------------DGEEEE-F--------------------------- T_guttata_ENSTGUP00000000363 -------------------------------------------------------------------------------------DDLDEE----------------------------- T_nigroviridis_ENSTNIP00000005512 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000056793 -------------------------------------------------------------------------------------DGEEEE-D--------------------------- T_nigroviridis_ENSTNIP00000007469 -------------------------------------------------------------------------------------YHDEEE----------------------------- O_cuniculus_ENSOCUP00000008041 -------------------------------------------------------------------------------------FEEE------------------------------- M_mulatta_ENSMMUP00000016400 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- O_cuniculus_ENSOCUP00000011938 -------------------------------------------------------------------------------------FEEEVEEE--------------------------- O_anatinus_ENSOANP00000006726 -------------------------------------------------------------------------------------KQEP------------------------------- M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 -------------------------------------------------------------------------------------XXXE------------------------------- C_intestinalis_ENSCINP00000018746 -------------------------------------------------------------------------------------DQEDGEED--------------------------- A_gambiae_AGAP005075-PB -------------------------------------------------------------------------------------DWKSVESDYNN------------------------ A_aegypti_AAEL001605-PA -------------------------------------------------------------------------------------DWNEEDGE--------------------------- D_melanogaster_FBpp0112004 -------------------------------------------------------------------------------------ASTDEQSVINATPQPPSNSNLSFVILLYWFLAILN G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 -------------------------------------------------------------------------------------DSEEEE----------------------------- P_pygmaeus_ENSPPYP00000001060 -------------------------------------------------------------------------------------YEEEEEEE--------------------------- C_elegans_F33H2.3 -------------------------------------------------------------------------------------DSEEG------------------------------ C_elegans_T19H12.2 -------------------------------------------------------------------------------------DSDEG------------------------------ A_aegypti_AAEL012656-PD -------------------------------------------------------------------------------------LAMPAA----------------------------- A_gambiae_AGAP007670-PB -------------------------------------------------------------------------------------QALPAG----------------------------- A_aegypti_AAEL006840-PA -------------------------------------------------------------------------------------LAMPAA----------------------------- D_melanogaster_FBpp0088015 -------------------------------------------------------------------------------------MSAAAA----------------------------- T_nigroviridis_ENSTNIP00000009472 -------------------------------------------------------------------------------------TFTIGA----------------------------- T_rubripes_ENSTRUP00000000150 -------------------------------------------------------------------------------------TFTIGA----------------------------- G_gallus_ENSGALP00000011598 -------------------------------------------------------------------------------------TFNPGA----------------------------- A_carolinensis_ENSACAP00000003100 -------------------------------------------------------------------------------------TFNPGA----------------------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 -------------------------------------------------------------------------------------TFNPGA----------------------------- C_intestinalis_ENSCINP00000011422 -------------------------------------------------------------------------------------INQENPGFFDMVINSDKLGEAYDRLRQLVMDYLGT P_pygmaeus_ENSPPYP00000021193 -------------------------------------------------------------------------------------KNEDKRSNAGFDGRWYTDINATL------------ T_rubripes_ENSTRUP00000025664 ANFLSQITMLNLHGHSLNKIKAVSSLTALRHLNISFNAFTRLDDISHMPNLEFLDASYNHLITLEGLRDLERLKHLDVSWNKLTKSREEAAVLRKHTPTLLKLDTRHNPWKKPKSVRLTL M_mulatta_ENSMMUP00000020530 -------------------------------------------------------------------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA B_taurus_ENSBTAP00000018076 -------------------------------------------------------------------------------------TFNPGA----------------------------- E_caballus_ENSECAP00000017313 -------------------------------------------------------------------------------------TFNPGA----------------------------- O_anatinus_ENSOANP00000018632 -------------------------------------------------------------------------------------TFNPGA----------------------------- M_domestica_ENSMODP00000015061 -------------------------------------------------------------------------------------TFNPGA----------------------------- G_aculeatus_ENSGACP00000013527 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000032723 -------------------------------------------------------------------------------------TFNPGA----------------------------- R_norvegicus_ENSRNOP00000016758 -------------------------------------------------------------------------------------TFNPGA----------------------------- C_familiaris_ENSCAFP00000015542 -------------------------------------------------------------------------------------TFNPGA----------------------------- H_sapiens_ENSP00000254193 -------------------------------------------------------------------------------------TFNPGA----------------------------- M_mulatta_ENSMMUP00000015518 -------------------------------------------------------------------------------------TFNPGA----------------------------- P_pygmaeus_ENSPPYP00000007744 -------------------------------------------------------------------------------------TFNPGA----------------------------- P_troglodytes_ENSPTRP00000041754 -------------------------------------------------------------------------------------TFNPGA----------------------------- H_sapiens_ENSP00000250173 -------------------------------------------------------------------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA P_troglodytes_ENSPTRP00000035210 -------------------------------------------------------------------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA R_norvegicus_ENSRNOP00000037753 -------------------------------------------------------------------------------------DEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEA E_caballus_ENSECAP00000002990 -------------------------------------------------------------------------------------EGKKERSQPGFDGRWYTDIGAPLPSSVESKD-LQA G_gorilla_ENSGGOP00000008764 -------------------------------------------------------------------------------------TFNPGA----------------------------- 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -------------D-EDEEEEG-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 -------------D-EDEEEEG-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 -------------E-EENEEGE-------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 -------------D-EEEEEEG-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 -------------D-EDEEEEG-------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 -------------E-EDEEEEG-------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 -------------D-EEEEEEG-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 ----------EEGE-EDDEEEG-------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 -------------D-DEDEEEG-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 -------------R-RKFSSGK-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000329250 -------------G-EEEEEEG-------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010000 -------------DEEEEEEEG-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 -------------R-RGRASRT-------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 -------------D-EEEEEEG-------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 -------------D-EEEEEEG-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 -------------E-EEYDEDA-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 -------------D-EDEEEEG-------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 -------------E-EDEEEEG-------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 -------------X-XXXXXXX-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 -------------D-EGDEDEE-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 --------DEEDDDEE-DDVEG-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 -------LNDKEGD-DDDEEEG-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 -------DEEEDDEEDEEEVEG-------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 --------VIDEEDDEDDDLEG-------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 -------DEEEDDDEDEEEIGE-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 -------------E-EDEEEEG-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 -------DEEEEDEEDEEEVEG-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 -------------G-EDEEEEG-------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 -------DEE---DED-EEGEG-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 -------DEEEDEDDDEDEVEG-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 -------DEEEDEDED-EDVEG-------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 ---------------DEEDDDA-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 -------DEE--DDED-EDVEG-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000345848 -------DEE--DDED-EDVEG-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 -------DEE--DDED-EDVEG-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 -------DEE--DDED-EDVEG-------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 ---------------EEEDEEG-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 -------EDEEEEDDE-EVVAE-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 -----------SGDVEDILHKG-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 -------DDEEDDDED-EDVEG-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 ---------SLPLQDEDEDEDG-------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 ---------------DEDEEGA-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 -----------------DEEGG-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 -------DEEEDDEEDEEEVEG-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025080 -------------DDE-KCLSG-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 -------------EDEEDDEDG-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 -------E---EDEDEDEDEAG-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 -------DEEEDDEEDEEEVEG-------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 -------XXX--XXXX-XXXXX-------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000040136 ---------------DDEDDGG-------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 -------DDEEDEDED-EDVEG-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 -----------EDEDEDEDEAG-------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 -------------EDDDEDEAG-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 -------E---EDEDEDEDEAG-------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 -------EDEEDEDED-EDVEG-------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 -------EFEDELDDEEDDEEG-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 ---------------EDEDEDG-------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 -------E---EDEDEDEDEAG-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000324074 -------EEEDEDEDEDEDEAG-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 -------EEEDEDEDEDEDEAG-------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 -------E-----EDEDEDEAG-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 -----------EHKDEDDAEVG-------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 --------------DEDDEEHG-------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 -------EEXDEDEDEDEDEAG-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000020657 ---------------DDEDEED-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023408 -------IISESVKNFVINLNC-------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ---------------DDEDDGA-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 -------DDEEDEDED-EDGEG-------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 --------VIDDE-DEDDDLEG-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 ----------------DEDEAG-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 -------EDEEDEDED-EDVEG-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 -----------EHKDEEEAEVG-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 ---------------EDEDEAG-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 -------EDEDEDEDEDEDEAG-------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 -----------EDEDEGEDEAG-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 -------------ENQWLHRAG-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 ---------------DDEDEAG-------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 -------DDEEDGVPVNEDSRN-------------------------------------------------------------------------------------------------- A_gambiae_AGAP005075-PB -------ADEEFDSEEEEDEEG-------------------------------------------------------------------------------------------------- A_aegypti_AAEL001605-PA -------DDEDFDDPTDEDEDD-------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112004 LGSATYFSDEDDDSDDSDEEAN-------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 -------FDGDEDEDESEDVDC-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 -------EEEDEDDDEDEDEAG-------------------------------------------------------------------------------------------------- C_elegans_F33H2.3 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T19H12.2 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL012656-PD ------------DKPTVHN----------------------------------------------------------------------------------------------------- A_gambiae_AGAP007670-PB ------------ALGESSPEK--------------------------------------------------------------------------------------------------- A_aegypti_AAEL006840-PA ------------DKPTVHN----------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0088015 ------------IAAEAGNGKG-------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 ------------ATPLEKKKTG-------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 ------------AAPLEKKKTG-------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000011598 ------------GLPTDKKKAG-------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 ------------GLPTDKKKTG-------------------------------------------------------------------------------------------------- C_elegans_F43G6.3 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000009232 ------------GLPTDKKKTG-------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 TDLSGADAEVAVPRLSTTEHKE-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 ------------------------------------------------------------------------------IDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI T_rubripes_ENSTRUP00000025664 LGYLKTLTHLDGVTVAEEEAAEAVQMVAGSKINQASLLSHSRTNSERPHRLSLLPTAQLLCLLNPPPWGLTQDLGPDWAAKITTLDFNSQGIYKLTNLSGLVNLRWASFNDNDLSKVEGL M_mulatta_ENSMMUP00000020530 PDTEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKNQEKLSERKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLINVDVQPTYVRVMI B_taurus_ENSBTAP00000018076 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017313 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000018632 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000015061 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ------------CKPWVEDNYW-------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000254193 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250173 PDTEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI P_troglodytes_ENSPTRP00000035210 PDIEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKNQEKLSEKKKKVKPPRTLIAEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI R_norvegicus_ENSRNOP00000037753 ERKETNHEGETEAEGKEADHEG-------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002990 PEIQEGECNRKKVEDEEDDLEFWNKPSLFTPESRLETLRHMEKQRKAQEKLSDKKKKVKPARTLITEDGKALNVNEPKLDFSLKDDEKRKQIVLDLAVYRYLDTSLIDVDVRPTYVRVLV G_gorilla_ENSGGOP00000008764 ------------GLPTDKKKGG-------------------------------------------------------------------------------------------------- 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- P_pygmaeus_ENSPPYP00000007477 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- G_aculeatus_ENSGACP00000022373 -----------EEE-EV--SG----------------------------------------------------------------------------------------EKEE------- C_familiaris_ENSCAFP00000025783 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- P_troglodytes_ENSPTRP00000039448 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- A_carolinensis_ENSACAP00000013586 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- G_gallus_ENSGALP00000013053 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- D_rerio_ENSDARP00000022360 --------EEEEEE-DI--SG----------------------------------------------------------------------------------------EEE-------- X_tropicalis_ENSXETP00000017086 -----------EEE-EV--SG----------------------------------------------------------------------------------------EEEE------- M_domestica_ENSMODP00000034651 -----------RVL-EE--NI----------------------------------------------------------------------------------------GLEE------- H_sapiens_ENSP00000329250 -----------EEE-DV--SG----------------------------------------------------------------------------------------GDEE------- T_guttata_ENSTGUP00000010000 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- O_anatinus_ENSOANP00000021355 -----------LLA-EV--QK----------------------------------------------------------------------------------------DPRE------- B_taurus_ENSBTAP00000016410 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- E_caballus_ENSECAP00000002350 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- T_nigroviridis_ENSTNIP00000012431 -----------APG-DL--SG----------------------------------------------------------------------------------------EEE-------- M_mulatta_ENSMMUP00000029913 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- M_musculus_ENSMUSP00000082652 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- G_gorilla_ENSGGOP00000015042 -----------XXX-XX--XX----------------------------------------------------------------------------------------XXXX------- T_rubripes_ENSTRUP00000042944 -----------DED-DL--SG----------------------------------------------------------------------------------------EEE-------- M_domestica_ENSMODP00000003980 ----------DDYEYDV--SG----------------------------------------------------------------------------------------E---------- O_latipes_ENSORLP00000002331 -----------EQNAHV--RH----------------------------------------------------------------------------------------LELE------- T_nigroviridis_ENSTNIP00000013976 ----------EEDDDEV--SG----------------------------------------------------------------------------------------EDE-------- G_gallus_ENSGALP00000002398 ----------EEEEDGV--DD----------------------------------------------------------------------------------------E---------- X_tropicalis_ENSXETP00000022463 ----------EEDEEDA--SG----------------------------------------------------------------------------------------EEE-------- R_norvegicus_ENSRNOP00000020443 -----------EEE-DV--SG----------------------------------------------------------------------------------------EEEE------- O_latipes_ENSORLP00000008884 ----------EDDDEEV--SG----------------------------------------------------------------------------------------EDEVNFVSSK- P_troglodytes_ENSPTRP00000028434 -----------EEE-DV--SG----------------------------------------------------------------------------------------GEEE------- A_carolinensis_ENSACAP00000004238 ---------EEDEEDEI--SG----------------------------------------------------------------------------------------E---------- D_rerio_ENSDARP00000033105 ----------EEDDEDG--SG----------------------------------------------------------------------------------------EDE-------- O_cuniculus_ENSOCUP00000005024 ----------EEDEDEV--SG----------------------------------------------------------------------------------------E---------- A_carolinensis_ENSACAP00000007900 ---------SDLGEVEG--EE----------------------------------------------------------------------------------------EEEEVGLSYL- M_mulatta_ENSMMUP00000016055 ----------DEDDDEV--SE----------------------------------------------------------------------------------------E---------- H_sapiens_ENSP00000345848 ----------DEDDDEV--SE----------------------------------------------------------------------------------------E---------- P_pygmaeus_ENSPPYP00000021773 ----------DEDDDEV--SE----------------------------------------------------------------------------------------E---------- P_troglodytes_ENSPTRP00000036180 ----------DEDDDEV--SE----------------------------------------------------------------------------------------E---------- D_rerio_ENSDARP00000071527 ---------SEGG---------------------------------------------------------------------------------------------------EVGLSYL- T_rubripes_ENSTRUP00000019528 ----------EEEDESG--ED----------------------------------------------------------------------------------------EDG-------- O_anatinus_ENSOANP00000017079 ---------QIIFE-------------------------------------------------------------------------------------------------EPAGISEV- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ----------EEDEDEV--SG----------------------------------------------------------------------------------------E---------- O_anatinus_ENSOANP00000020934 ----------EDDEDE---------------------------------------------------------------------------------------------DGEEVGLSPF- X_tropicalis_ENSXETP00000034315 ---------SDLGDEEE--EE----------------------------------------------------------------------------------------EEEEVGLSYL- R_norvegicus_ENSRNOP00000043155 -----------EEE-NV--SG----------------------------------------------------------------------------------------EEEDE------ O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 ----------EDDD-EV--SG----------------------------------------------------------------------------------------EDE-------- O_latipes_ENSORLP00000025080 ----------FPVGRRG--QR----------------------------------------------------------------------------------------RCGQQP----- O_latipes_ENSORLP00000001658 ---------SEGGE---------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- T_rubripes_ENSTRUP00000027152 ----------EEDDDEV--SG----------------------------------------------------------------------------------------EDE-------- G_gorilla_ENSGGOP00000011344 ----------XXXXXXX--XX----------------------------------------------------------------------------------------X---------- G_gallus_ENSGALP00000040136 ---------SDLGE-----GE----------------------------------------------------------------------------------------EEEEVGLSYL- C_familiaris_ENSCAFP00000003588 ----------EEDEDEV--SG----------------------------------------------------------------------------------------EVGANVFAALF R_norvegicus_ENSRNOP00000028744 ---------SEVGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- M_musculus_ENSMUSP00000015893 ---------SEVGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- O_cuniculus_ENSOCUP00000005451 ---------SEVGE-----------------------------------------------------------------------------------------------G-EEVGLSFL- M_musculus_ENSMUSP00000083521 ----------EDDEDEV--SG----------------------------------------------------------------------------------------EVNTTVF---F X_tropicalis_ENSXETP00000021012 -------------------------------------------------------------------------------------------------------------EDE-------- G_aculeatus_ENSGACP00000013165 ---------SEGGG---------------------------------------------------------------------------------------------------AGPNRA- C_familiaris_ENSCAFP00000017286 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- H_sapiens_ENSP00000324074 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- P_troglodytes_ENSPTRP00000051813 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- B_taurus_ENSBTAP00000022237 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- T_rubripes_ENSTRUP00000010444 ---------HEGWSFHT--RP----------------------------------------------------------------------------------------GHEHIFLFF-- O_latipes_ENSORLP00000025809 ---------SE---------------------------------------------------------------------------------------------------EEEVGLSYL- G_gorilla_ENSGGOP00000011594 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSXL- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 -------------------------------------------------------------------------------------------------------------GEEEVGLSYL- T_rubripes_ENSTRUP00000020657 ---------EDGSD------G----------------------------------------------------------------------------------------DEDEVGLSYL- T_nigroviridis_ENSTNIP00000008152 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023408 ---------SNLGN--------------------------------------------------------------------------------------------------SIQLPFY- T_guttata_ENSTGUP00000004677 ---------SDLGE-----GE----------------------------------------------------------------------------------------EEEEVGLSYL- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ----------EEDEDEV--SG----------------------------------------------------------------------------------------E---------- T_guttata_ENSTGUP00000000363 ----------EEGEDGV--DD----------------------------------------------------------------------------------------E---------- T_nigroviridis_ENSTNIP00000005512 ---------PVGSE------G----------------------------------------------------------------------------------------EEDEVGLSYL- R_norvegicus_ENSRNOP00000056793 ----------EDDEDEV--SG----------------------------------------------------------------------------------------EVN-TLF---F T_nigroviridis_ENSTNIP00000007469 ---------HEGWSFHT--RP----------------------------------------------------------------------------------------GRE-------- O_cuniculus_ENSOCUP00000008041 ---------SELGE-----------------------------------------------------------------------------------------------G-EEVGLSYL- M_mulatta_ENSMMUP00000016400 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- O_cuniculus_ENSOCUP00000011938 ---------SEVGE-------------------------------------------------------------------------------------------------GEVGLSYL- O_anatinus_ENSOANP00000006726 ---------SDPGE------G----------------------------------------------------------------------------------------EEEEVGLSYL- M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVDLSYL- C_intestinalis_ENSCINP00000018746 ---------SVEDESDAGSDE----------------------------------------------------------------------------------------EEEEVGLAYL- A_gambiae_AGAP005075-PB ---------GGGGGGGGENEG----------------------------------------------------------------------------------------EDGGDSDGKG- A_aegypti_AAEL001605-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112004 ---------GEVSLSEVYNDD----------------------------------------------------------------------------------------LEEDNSDWEG- G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ----------EEGDDEK--EG----------------------------------------------------------------------------------------D---------- P_pygmaeus_ENSPPYP00000001060 ---------SELGE-----------------------------------------------------------------------------------------------GEEEVGLSYL- C_elegans_F33H2.3 -------------------SG----------------------------------------------------------------------------------------DEDGPGLSYL- C_elegans_T19H12.2 -------------------DS----------------------------------------------------------------------------------------DEDGPGLSYL- A_aegypti_AAEL012656-PD -----------------ATPA----------------------------------------------------------------------------------------DIQK------- A_gambiae_AGAP007670-PB ------------QAVQNASPA----------------------------------------------------------------------------------------DIQK------- A_aegypti_AAEL006840-PA -----------------ATSA----------------------------------------------------------------------------------------DIQK------- D_melanogaster_FBpp0088015 ---------RGSEGGRLANPQ----------------------------------------------------------------------------------------DMQR------- T_nigroviridis_ENSTNIP00000009472 -----------------PSQA----------------------------------------------------------------------------------------DVEA------- T_rubripes_ENSTRUP00000000150 -----------------PSQA----------------------------------------------------------------------------------------DVEA------- G_gallus_ENSGALP00000011598 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- A_carolinensis_ENSACAP00000003100 -----------------PTPG----------------------------------------------------------------------------------------DVEA------- C_elegans_F43G6.3 -----------------------------------------------------------------------------------------------------------------PNYSRI- T_guttata_ENSTGUP00000009232 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- C_intestinalis_ENSCINP00000011422 ----------ESGTHQTTLSGHMRRTWSRPSFHG---------------------------------------------------------------------------DSTNSNDPNS- P_pygmaeus_ENSPPYP00000021193 KGKPFQLVLPAEVKPDSSSAK----------------------------------------------------------------------------------------RSQTTGHLVIC T_rubripes_ENSTRUP00000025664 ECCVNLEELSLNNNNISTLSGLSKLQRLKKLSLNGNQLTSLDSSVLDQLPQLCFLSVEDNSIASLHGIRRARSLLEFYICNNCISMSKDIYCLKELANLIILDLSGNPVEKVENYRNYVL M_mulatta_ENSMMUP00000020530 KGKPFQLVLPAEVKPDSSSAK----------------------------------------------------------------------------------------RSQTTGHLVIC B_taurus_ENSBTAP00000018076 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- E_caballus_ENSECAP00000017313 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- O_anatinus_ENSOANP00000018632 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- M_domestica_ENSMODP00000015061 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- G_aculeatus_ENSGACP00000013527 -------------------------------------------------------------------------------------------------------------EIKRSNNAI-- M_musculus_ENSMUSP00000032723 -----------------PSAG----------------------------------------------------------------------------------------DVEA------- R_norvegicus_ENSRNOP00000016758 -----------------PSAG----------------------------------------------------------------------------------------DVEA------- C_familiaris_ENSCAFP00000015542 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- H_sapiens_ENSP00000254193 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- M_mulatta_ENSMMUP00000015518 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- P_pygmaeus_ENSPPYP00000007744 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- P_troglodytes_ENSPTRP00000041754 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- H_sapiens_ENSP00000250173 KGKPFQLVLPAEVKPDSSSAK----------------------------------------------------------------------------------------RSQTTGHLVIC P_troglodytes_ENSPTRP00000035210 KGKPFQLVLPAEVKPDSSSAK----------------------------------------------------------------------------------------RSQTTGHLVIC R_norvegicus_ENSRNOP00000037753 ---------ETEAEGNVEHQG----------------------------------------------------------------------------------------ETEAEGKVEHE E_caballus_ENSECAP00000002990 KGKPFQLVLPAEVKPDSSSAK----------------------------------------------------------------------------------------RSQTTGHLVIC G_gorilla_ENSGGOP00000008764 -----------------PSPG----------------------------------------------------------------------------------------DVEA------- 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------LG- P_pygmaeus_ENSPPYP00000007477 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------LG- G_aculeatus_ENSGACP00000022373 --------------EEEDLN-DKE----------ADDE-------------------------------------------DD------------------EGE-------------LK- C_familiaris_ENSCAFP00000025783 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EED-------------VG- P_troglodytes_ENSPTRP00000039448 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------LG- A_carolinensis_ENSACAP00000013586 --------------DEEGYN-DGE----------VDDE-------------------------------------------EE------------------EEE-----------A-AA- G_gallus_ENSGALP00000013053 --------------DEEGYN-DGD----------VDDD-------------------------------------------ED------------------EEE--------------P- D_rerio_ENSDARP00000022360 --------------EEEELN-DGE----------VDDE-------------------------------------------ED-----------------------------------F- X_tropicalis_ENSXETP00000017086 --------------DEDAYR-EGE-----------EDE-------------------------------------------AD------------------E------------------ M_domestica_ENSMODP00000034651 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EDE-------------VG- H_sapiens_ENSP00000329250 --------------DEEGYN-DGE----------VDGE-------------------------------------------ED------------------EEE-------------LG- T_guttata_ENSTGUP00000010000 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE--------------P- O_anatinus_ENSOANP00000021355 --------------DEEGYN-DGE----------VDDD-------------------------------------------ED------------------EEE-------------LG- B_taurus_ENSBTAP00000016410 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------LG- E_caballus_ENSECAP00000002350 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EED-------------LG- T_nigroviridis_ENSTNIP00000012431 --------------EEEDLN-DRE----------VDDE-------------------------------------------DE------------------EGE-------------VP- M_mulatta_ENSMMUP00000029913 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------LG- M_musculus_ENSMUSP00000082652 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EEE-------------AG- G_gorilla_ENSGGOP00000015042 --------------XXXXXX-XXX----------XXXX-------------------------------------------XX------------------XXX-------------XX- T_rubripes_ENSTRUP00000042944 --------------EEEDLN-DRE----------VDDE-------------------------------------------DE------------------E------------------ M_domestica_ENSMODP00000003980 --------------EEEFGH-DGE----------VDDD-------------------------------------------EE------------------DEE-------------DE- O_latipes_ENSORLP00000002331 --------------EERGQKRKRE----------LDEE-------------------------------------------GE------------------EDD-----------D-DL- T_nigroviridis_ENSTNIP00000013976 --------------EEEFGQ-DGE----------VDEE-------------------------------------------DE------------------DED--EDDD-------EA- G_gallus_ENSGALP00000002398 --------------EEDEEE-DGE----------DEED-------------------------------------------DE------------------ADD---------------- X_tropicalis_ENSXETP00000022463 --------------EEDFGH-DGE----------VDED-------------------------------------------DD------------------EED--DEED---E-E-EE- R_norvegicus_ENSRNOP00000020443 --------------DEEGYN-DGE----------VDDE-------------------------------------------ED------------------EED-------------AA- O_latipes_ENSORLP00000008884 --------------EEEFGQ-DGE----------VEDE-------------------------------------------DE------------------DED--EDEE---G-M-QA- P_troglodytes_ENSPTRP00000028434 --------------DEEGYN-DGE----------VDGE-------------------------------------------ED------------------EEE-------------LG- A_carolinensis_ENSACAP00000004238 --------------EEEFGR-DGE-------------E-------------------------------------------ED------------------EEE--EEED---E-D-EE- D_rerio_ENSDARP00000033105 --------------EEDFGQ-DGE----------VEDD-------------------------------------------EE------------------DDD--DDDD---E-E-EE- O_cuniculus_ENSOCUP00000005024 --------------EEEFGH-DGE-----------------------------------------------------------------------------DED--EDED---E-E-EE- A_carolinensis_ENSACAP00000007900 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EER--ENE-----EE-EA- M_mulatta_ENSMMUP00000016055 --------------EEEFGL-DEE-----------------------------------------------------------------------------DED--EDED---E-E-EE- H_sapiens_ENSP00000345848 --------------EEEFGL-DEE-----------------------------------------------------------------------------DED--EDED---E-E-EE- P_pygmaeus_ENSPPYP00000021773 --------------EEEFGL-DEE-----------------------------------------------------------------------------DED--EDED---E-E-EE- P_troglodytes_ENSPTRP00000036180 --------------EEEFGL-DEE-----------------------------------------------------------------------------DED--EDED---E-E-EE- D_rerio_ENSDARP00000071527 --------------MKEDIQ-DEE----------DDDD-------------------------------------------YV------------------EEE-EEEG-----GE-EE- T_rubripes_ENSTRUP00000019528 --------------EVNGDL-DSE----------DEED-------------------------------------------EE------------------EED--EDE----D-E-DS- O_anatinus_ENSOANP00000017079 --------------EEEDFE-HQSWETKPVINFGVDSD-------------------------------------------ED------------------DVD-------------EE- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 --------------GEKAGN-IGE----------RSDF-------------------------------------------NP------------------NEDLVKDQD---R-E-EE- O_anatinus_ENSOANP00000020934 --------------MSLPLP-------------------------------------------------------------------------------------------------AP- X_tropicalis_ENSXETP00000034315 --------------MKEEIR-DEE----------DDDD-------------------------------------------YV------------------EDGAEGEE-----EE-EED R_norvegicus_ENSRNOP00000043155 --------------EEEGYN-TG-----------LDDE-------------------------------------------ED------------------EDD--------AG-E-ET- O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 --------------EEDFAQ-DGE----------VDDE-------------------------------------------D-------------------DDD--EDEE---E-A-EA- O_latipes_ENSORLP00000025080 --------------EVQQEM-MSS----------GKEN--------------------------------------------L------------------IIF--PSA----D-E-DS- O_latipes_ENSORLP00000001658 -----------------EEY-NEE----------DDD---------------------------------------------------------------------AEE-----ED-DQ- M_domestica_ENSMODP00000004440 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- T_rubripes_ENSTRUP00000027152 --------------EEDFAQ-DGE----------VDEE-------------------------------------------DD------------------DDD--DEDDEEFH-K-EA- G_gorilla_ENSGGOP00000011344 --------------EEEFGL--EE-----------------------------------------------------------------------------DED--XDED---E------ G_gallus_ENSGALP00000040136 --------------MKEEIQ-DED----------DDDD-------------------------------------------YV------------------EEG--GDE-----EE-EA- C_familiaris_ENSCAFP00000003588 PICRRKQ-------EEEFGH-DGE----------VDED-------------------------------------------ED------------------DED--EDED---E-E-EE- R_norvegicus_ENSRNOP00000028744 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------DEG-EEEE-----EE-EE- M_musculus_ENSMUSP00000015893 --------------MKDEIQ-DEE----------DDDD-------------------------------------------YV------------------DEG-EEEE-----EE-EE- O_cuniculus_ENSOCUP00000005451 --------------MKDEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----DE-EE- M_musculus_ENSMUSP00000083521 PICVKTK-------EEEFGH-DGE----------VDED-------------------------------------------EE------------------DED--EDED---E-E-EE- X_tropicalis_ENSXETP00000021012 --------------EGEEEE-EGD----------EEDE---------------------------------------------------------------DDE---------------- G_aculeatus_ENSGACP00000013165 --------------DQPPLP-PQN----------SLSL-------------------------------------------------------------------SPAC-----PE-EQ- C_familiaris_ENSCAFP00000017286 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- H_sapiens_ENSP00000324074 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- P_troglodytes_ENSPTRP00000051813 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- B_taurus_ENSBTAP00000022237 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEGEEEEE-----EE-EE- T_rubripes_ENSTRUP00000010444 --------------PFNFYY--------------LEDE-------------------------------------------EN------------------DE------------E-EV- O_latipes_ENSORLP00000025809 --------------MKDGIQ-EYK----------LADY-------------------------------------------FC------------------WSGRDCKQISHVWDQ-YE- G_gorilla_ENSGGOP00000011594 --------------MKEDIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEXE-----EE-EE- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 --------------MKEGIQ-DEE----------DDGD-------------------------------------------YV------------------KSPFLTDV--------DG- T_rubripes_ENSTRUP00000020657 --------------MKEGIQ-DED----------DDGD-------------------------------------------YV------------------EEE-EEE---------ED- T_nigroviridis_ENSTNIP00000008152 ---------------------------------CAPDE-------------------------------------------------------------------------------DP- M_domestica_ENSMODP00000023408 --------------LKKLKF-TSE----------YVES-------------------------------------------FV------------------KKI-LNNNNNSTFIL-EE- T_guttata_ENSTGUP00000004677 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV-------------------EG--GDE-----EE-EA- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 --------------EEEFGH-DGE----------VDDD-------------------------------------------ED------------------DED--EDED---E-E-EE- T_guttata_ENSTGUP00000000363 --------------EEDEEE-DGE----------EDEE-------------------------------------------DE------------------AEE---------------- T_nigroviridis_ENSTNIP00000005512 --------------MKEGIQ-DED----------DDGD-------------------------------------------YM------------------WRR-------------RP- R_norvegicus_ENSRNOP00000056793 PVGVKAK-------EEEFGH-DGE----------VDED-------------------------------------------EE------------------DED--EDED---E-E-EE- T_nigroviridis_ENSTNIP00000007469 -----------------FLS--------------REDE-------------------------------------------DD------------------EEG------SSPSVE-EA- O_cuniculus_ENSOCUP00000008041 --------------MKDEIQ-D-E----------DDDD-------------------------------------------YV----------------------EEEE-----EE-DE- M_mulatta_ENSMMUP00000016400 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- O_cuniculus_ENSOCUP00000011938 --------------MKDEIQ-E-------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 --------------MKEEIQ-DED----------DDDD-------------------------------------------YV------------------DRX-EGRK-----LS-KE- M_domestica_ENSMODP00000019786 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 --------------MKDEIQ-DE------------DDD-------------------------------------------YV------------------GEG-EEEG-----DE-EE- C_intestinalis_ENSCINP00000018746 --------------DGDDIE-DED----------DDGD-------------------------------------------YD------------------GEEEEEEEEDDDIDE-EEQ A_gambiae_AGAP005075-PB --------------EDEEGEEEED----------GEDD-------------------------------------------ADGSEAAASSTAAVAAEADESKSTATEAAAATSST-TED A_aegypti_AAEL001605-PA --------------GEGEGEGEGE--------------------------------------------------------------------GEVAAENAGSDSEAGEE----------- D_melanogaster_FBpp0112004 --------------EDEAGEEDE------------EED-------------------------------------------SD---------------IDDADGDANESAASVNAK-DKD G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 --------------DESEDV-DCE----------EGDD-------------------------------------------ES------------------EDVDCEEGDDESEDV---- P_pygmaeus_ENSPPYP00000001060 --------------MKEEIQ-DEE----------DDDD-------------------------------------------YV------------------EEG-EEEE-----EE-EE- C_elegans_F33H2.3 --------------EKSQFS-DDETDD-----Y-APEG-------------------------------------------GD------------------------------------- C_elegans_T19H12.2 --------------NKSQFS-DDETDD-----YVVPEA-------------------------------------------GD------------------------------------- A_aegypti_AAEL012656-PD --------------IKEAIK---------------------------------------------------------------------------------RATNLHEVERLTRML-QS- A_gambiae_AGAP007670-PB --------------IKEAIK---------------------------------------------------------------------------------RATNLHEVERLNRML-QS- A_aegypti_AAEL006840-PA --------------IKEAIK---------------------------------------------------------------------------------RATNLHEVERLTRML-QS- D_melanogaster_FBpp0088015 --------------IREAIK---------------------------------------------------------------------------------RASSLAEVERLSQIL-QS- T_nigroviridis_ENSTNIP00000009472 --------------IKNAIA---------------------------------------------------------------------------------NASSLAEVERLKGML-QA- T_rubripes_ENSTRUP00000000150 --------------IKNAIA---------------------------------------------------------------------------------NASSLAEVERLKGML-QA- G_gallus_ENSGALP00000011598 --------------IKTAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QA- A_carolinensis_ENSACAP00000003100 --------------IKNAIA---------------------------------------------------------------------------------NATTLAEVERLKGLL-QA- C_elegans_F43G6.3 --------------PKSIRE-DAEKERQWIILWQLLSS-------------------------------------------PK------------------------------------- T_guttata_ENSTGUP00000009232 --------------IKAAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QA- C_intestinalis_ENSCINP00000011422 --------------AKNQIKLDSRKTPVEEASYRRRQNAAKEAVEGFSPSVYDELFRRPMVPMTAPGMLEGSPMAQAASLYQDPAFAASMYPNMSQVTIENGQNYISDKTKSDRISPDSS P_pygmaeus_ENSPPYP00000021193 MPKVGEVITGGQRAFKSMKTTSDR----------SREQ-------------------------------------------TN------------------TRSKHMEKLEVDPSK-HSF T_rubripes_ENSTRUP00000025664 FHLPELKALDGAAVEAPECESAKEMFGGRLIPDVLTERLGLTNCADITSLTLQSFSIRVVDLNPPELFSSLHTVRLDHNNLTSFSGLVHLPHIRDLSLNYNHIESVLPKQKIPNLT-NKQ M_mulatta_ENSMMUP00000020530 MPKVGEVITGGQRAFTSVKTTLDR----------SREH-------------------------------------------IN------------------TRSKHMEKLEVDPSK-HSF B_taurus_ENSBTAP00000018076 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- E_caballus_ENSECAP00000017313 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QA- O_anatinus_ENSOANP00000018632 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- M_domestica_ENSMODP00000015061 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- G_aculeatus_ENSGACP00000013527 --------------IEEAYK---------------------------------------------------------------------------------QFNDVLHECRLLNNRATHV M_musculus_ENSMUSP00000032723 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- R_norvegicus_ENSRNOP00000016758 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- C_familiaris_ENSCAFP00000015542 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- H_sapiens_ENSP00000254193 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- M_mulatta_ENSMMUP00000015518 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- P_pygmaeus_ENSPPYP00000007744 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- P_troglodytes_ENSPTRP00000041754 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- H_sapiens_ENSP00000250173 MPKVGEVITGGQRAFKSMKTTSDR----------SREQ-------------------------------------------TN------------------TRSKHMEKLEVDPSK-HSF P_troglodytes_ENSPTRP00000035210 MPKVGEVITGGRRAFKSMKTTSDR----------SREQ-------------------------------------------TN------------------TRSKHMEKLEVDPSK-HSF R_norvegicus_ENSRNOP00000037753 GETEAG--------EKDEHEGQSETQADDTEVKDGEGE---------------------------------------------------------------AEANAEDQCETAQGEKGAD E_caballus_ENSECAP00000002990 MPKVDEVITGCPPASKPVASTLDS----------SRER-------------------------------------------KT------------------ERSRHTEKLEVDPSK-RSF G_gorilla_ENSGGOP00000008764 --------------IKNAIA---------------------------------------------------------------------------------NASTLAEVERLKGLL-QS- 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 -------EVEQGQKRKRELDEE-G-E---------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 -------EEERGEKRKREADDE-G-D---------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 -------DEERGQKRKREPEDE-G-D---------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 -------EEERGLKRKRELDEE-G-E---------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 -------EAEHGQKRKREQDDD-G-E---------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 -------EEEKGQKRKREPEDG-G-D---------------------------------------------------------------------------------------------- H_sapiens_ENSP00000329250 -------EEERGQKRK-------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010000 -------EEERGQKRKREPEDE-G-D---------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 -------EEERGQKRKREPEDE-G-D---------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 -------EEERGQKRKRELDEE-G-E---------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 -------EEERGQKRKREPEDE-G-E---------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 -------EEEGSQKRKREPDDE-G-E---------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 -------XXXXXXKRKXEPEDE-G-E---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 -------EEERGQKRKRELDEE-G-E---------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 -------ETGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 -------DEERGQKRKRELDEE-G-E---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 -------EAGKGEKRKRDPEDE-D-D---------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 -------DLPRGEKRKRNLEDE-G-E---------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 -------ESGKGEKRKRETDDD-G-D---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 -------EEEGSQKRKREPDDE-G-E---------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 -------EAGKGEKRKRDPEDE-D-E---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 -------EEERGQKRK-------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 -------ESGKGEKRKREADDE-G-D---------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 -------QGAKGEKRKREADDE-D-D---------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 -------ESGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 -------EALRGEKRKRAAEDE-G-D---------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 -------EGGKGEKRKRETDDE-G-D---------------------------------------------------------------------------------------------- H_sapiens_ENSP00000345848 -------EGGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 -------EGGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 -------EGGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 -------ADVRGEKRKREAEDE-G-E---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 -------TAAKGEKRKRDVEDE-G-D---------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 -------ETGRGEKRKRESDDD-G-D---------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 -------ESGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 -------DHPQGEKRKRDLEDE-G-E---------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 EEDEAAAAADRGEKRKRDPEDD-G-D---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 -------ERERDRDRDRETERQ-R-D---------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 -------EAG-------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025080 -------SPVKGEKRKRDPEDE-D-E---------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 -------AGAPG------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004440 --------PQHGEKRKRATDDE-G------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006868 -------EGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 -------DAGKGEKRKRDPEDE-D-D---------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000040136 -------EGIRGEKRKRDPEDE-G-E---------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 -------ESGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 -------EGPRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 -------EGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 -------ECLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 -------ESGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 -------DVPQGEKRKRDLEDD-GDE---------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 -------PGVQREKRKRDVDDE-G-E---------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 -------EGLRGEKRKRDAEDD-G-D---------------------------------------------------------------------------------------------- H_sapiens_ENSP00000324074 -------GGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 -------GGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 -------EGLRGKR-GNEMLKM-M-E---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 -------ACTQGQKRKRSEDDE-N-N---------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 -------AAAQGEKRKRDAEDE-G-D---------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 -------GGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 -------ADVQGEKRKRDAEDD-G-D---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 -------GAFQGEKRKREAEDE-G-D---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 -------AAAKGEKRKRDVDDD-G-E---------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023408 -------ESVQGEKRKRDIEDE-G-E---------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 -------EGVRGEKRKREPEDE-G-E---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 -------ESGKGEKRKRETDDE-G-E---------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 -------DHPCGVKRKRSLEDE-G-E---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 -------QLFRVRREKRDVEDE-G-D---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 -------ESGKGEKRKRETDDE-A-K---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 -------ASTQGQKRKRSEDDE-N-E---------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 -------EYLLGEKRKRDAEDD-E-E---------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 -------EGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 -------ECPRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 -------EGTRGEKRKRDAADE-G-E---------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 ------------------TDEE-G------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003696 --------ECLGEKRK-DAEDD-G-V---------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 GAG----ESSRGVKRKHEEEEE-EGG---------------------------------------------------------------------------------------------- A_gambiae_AGAP005075-PB VAKEG-EPEARGKKRKFQGTDSDG------------------------------------------------------------------------------------------------ A_aegypti_AAEL001605-PA -------SEARGKKRKLEGNDG-------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112004 GEKEADESQVRGKKRKHD-----G------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 -------DCEEGDDESEDVDCE-EGD---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 -------GGLRGEKRKRDAEDD-G-E---------------------------------------------------------------------------------------------- C_elegans_F33H2.3 -------AEPRGTKRGASDNGE-EPD---------------------------------------------------------------------------------------------- C_elegans_T19H12.2 -------AETRGAKRAASADCD-EPE---------------------------------------------------------------------------------------------- A_aegypti_AAEL012656-PD -------GQITGE---------FNFN---------------------------------------------------------------------------------------------- A_gambiae_AGAP007670-PB -------GQITGD---------I-LN---------------------------------------------------------------------------------------------- A_aegypti_AAEL006840-PA -------GQITGE---------FNFN---------------------------------------------------------------------------------------------- D_melanogaster_FBpp0088015 -------GQLPDK---------F-QH---------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 -------GQIPGRDLRPDGNEMVEEE---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 -------GQIPGRDLRAGEADMVVEE---------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000011598 -------GQIPGRERKPGSAEDAEEE---------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 -------GQIPGRDRKAGPSDEAEEE---------------------------------------------------------------------------------------------- C_elegans_F43G6.3 -------SETR-------------PR---------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000009232 -------GQIPGRERKPGPSEDGEEE---------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 NSSNEDSTGLSGLSSARGFSDEESYSSRTATPLAPRIVDGL------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 PDVTNIVQEKKYTPRR-RPEPKIIPS---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 ILYNKVHSSGYGKQRSLKGKGEPGQSCGLEPLMDSLEVLHLSHNGISNMANLELSRLTSLKALFLEGNEIRHVDGLEGLHQLRELVLDKNRIKTLAEDSFISQNSLLELHLSENRIQDLG M_mulatta_ENSMMUP00000020530 PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018076 -------GQIPGRERRAGPTDDGEEE---------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017313 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000018632 -------GQIPGRERKSGPADDGEEE---------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000015061 -------GQIPGRERKSGPTDDGEEE---------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ISQTERSMSLKKQPKQYAI----------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 -------GQIPGRERRSGPSDEGEEE---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 -------GQIPGRERRSGPSDEGEEE---------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- H_sapiens_ENSP00000254193 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 -------GQIPGRERRSGPTDDGEEE---------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250173 PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 GGGGSDGGDSEEEEDEEDEEEEEEEE---------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002990 PDVANIVQEKKHTPRRVRSEPKITPT---------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 -------GQIPGRECRS------------------------------------------------------------------------------------------------------- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000386496 ------------DDD--------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 ------------DDD--------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 ------------EDEDD------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 ------------DDD--------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 ------------DDD--------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 ------------EED--------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 ------------EDD--------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 ------------EDDD-------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 ------------DDD--------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 ------------EDD--------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000329250 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010000 ------------EDD--------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 ------------EDD--------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 ------------DDD--------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 ------------DDD--------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 ------------EDE--------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 ------------DDD--------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 ------------EDD--------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 ------------DDD--------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 ------------EDEDD------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 ------------GE---------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 ------------EDDD-------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 ------------EDDDEDDD---------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 ------------EDPEDEEDDEDD------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000022463 ------------EEDD-------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 ------------EDD--------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 ------------DD---------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000004238 ------------ED---------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 ------------EDDEEDD----------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 ------------DD---------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 ------------EDDD-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 ------------DD---------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000345848 ------------DD---------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 ------------DD---------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 ------------DD---------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 ------------DDDEDDD----------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 ------------DDEE-------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 ------------EE---------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028486 ------------DD---------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 ------------EDP--------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 ------------EDED-------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 ------------T----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022955 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000025080 ------------EED--------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004440 ------------EDSEDEEED--------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000006868 ------------EEDD-------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 ------------ED---------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000040136 ------------EEDD-------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 ------------DDKTPNNLQRKNC----------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000028744 ------------EDDD-------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 ------------EDDD-------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 ------------EEDD-------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 ------------EPKNSSRDIPPSS----------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000021012 ------------EDDDDEEDDE-------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 ------------DDGDEDD----------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 ------------EEDD-------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000324074 ------------EEDD-------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 ------------EEDD-------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 ------------RKKM-------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 ------------ED---------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 ------------EDED-------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 ------------EEXD-------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004164 ------------DDDDE------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 ------------DDDD-------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 ------------DDED-------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023408 ------------EEDD-------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ------------EEED-------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000266594 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010263 ------------DD---------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 ------------EDAEDEEDDEDD------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005512 ------------DDDD-------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 ------------EPKNSSRDIPPSS----------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000007469 ------------D----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 ------------EEDD-------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 ------------EDD--------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 ------------DED--------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 ------------EEDD-------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 ------------EDIKEEEED--------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003696 ------------EEDD-------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 ------------ENE--------------------------------------------------------------------------------------------------------- A_gambiae_AGAP005075-PB ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL001605-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0112004 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000179 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000013309 ------------DE---------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 ------------EEDD-------------------------------------------------------------------------------------------------------- C_elegans_F33H2.3 ------------NKK--------------------------------------------------------------------------------------------------------- C_elegans_T19H12.2 ------------AKK--------------------------------------------------------------------------------------------------------- A_aegypti_AAEL012656-PD ------------GKLQPFVRLNLVS----------------------------------------------------------------------------------------------- A_gambiae_AGAP007670-PB ------------GNESH-------S----------------------------------------------------------------------------------------------- A_aegypti_AAEL006840-PA ------------GKLQPFVRLNLVS----------------------------------------------------------------------------------------------- D_melanogaster_FBpp0088015 ------------EMEAV-------A----------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 ------------EEEEA-------P----------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 ------------EEEEE-------G----------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000011598 ------------MEEDT-------V----------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 ------------MEEDS-------I----------------------------------------------------------------------------------------------- C_elegans_F43G6.3 ------------HKKYLLATSLLLS----------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000009232 ------------MEEDT-------V----------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 ------------EDWMESFDQPDKP----------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 ------------EEDPTFEDNPEVP----------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 HLGQLSKLRKLFLDSNRVQDITELE----------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000020530 ------------EEDPTFEDNPEVP----------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000018076 ------------MEEDT-------V----------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017313 ------------MEEDT-------V----------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000018632 ------------MEEDP-------V----------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000015061 ------------MEEDT-------V----------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000032723 ------------IEDDT-------V----------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 ------------MEDGT-------V----------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 ------------MEEDT-------V----------------------------------------------------------------------------------------------- H_sapiens_ENSP00000254193 ------------MEEDT-------V----------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 ------------MEEDT-------V----------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 ------------MEEDT-------V----------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 ------------MEEDT-------V----------------------------------------------------------------------------------------------- H_sapiens_ENSP00000250173 ------------EEDPTFEDNPEVP----------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 ------------EEDPTFEDNPEVP----------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 ------------EEEEEEESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQVRAVKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI E_caballus_ENSECAP00000002990 ------------EEDPDFEDNPEVP----------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 ------------------------------------------------------------------------------------------------------------------------ 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+======= H_sapiens_ENSP00000386496 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007477 ----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022373 ----------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000025783 ----------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000039448 ----------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000013586 ----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000013053 ----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000022360 ----------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017086 ----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000034651 ----------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000329250 ----------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010000 ----------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000021355 ----------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000016410 ----------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000002350 ----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012431 ----------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000029913 ----------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000082652 ----------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015042 ----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042944 ----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000003980 ----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000002331 ----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013976 ----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002398 ----------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000022463 ----------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000020443 ----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008884 ----------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000028434 ----------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000004238 ----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000033105 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005024 ----------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000007900 ----------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016055 ----------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000345848 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021773 ----------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000036180 ----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000071527 ----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000019528 ----------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000017079 ----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024521 ----------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028486 ----------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020934 ----------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000034315 ----------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000043155 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000076 ----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000022955 ----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025080 ----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001658 ----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000004440 ----------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000006868 ----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027152 ----------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011344 ----------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000040136 ----------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000003588 ----------------------------------------SPLLEIHHQAWGL-PHKIVSVVRFSCQTCCSV----------------------------------- R_norvegicus_ENSRNOP00000028744 ----------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000015893 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000005451 ----------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000083521 ----------------------------------------VSPLVIHHQAWGLRPNKIVNVVRFSCKTLAVS----------------------------------- X_tropicalis_ENSXETP00000021012 ----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013165 ----------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000017286 ----------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000324074 ----------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000051813 ----------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000022237 ----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010444 ----------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000025809 ----------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000011594 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005091 ----------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000004164 ----------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000020657 ----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000008152 ----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023408 ----------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004677 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007165 ----------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000266594 ----------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000010263 ----------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000363 ----------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005512 ----------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000056793 ----------------------------------------V-PLVIHHQAWGLRPNKIVSVVRFSCKTLAVS----------------------------------- T_nigroviridis_ENSTNIP00000007469 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000008041 ----------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016400 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011938 ----------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000006726 ----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019786 ----------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003696 ----------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000018746 ----------------------------------------------------------------------------------------------------------- A_gambiae_AGAP005075-PB ----------------------------------------------------------------------------------------------------------- A_aegypti_AAEL001605-PA ----------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0112004 ----------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000000179 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000013309 ----------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001060 ----------------------------------------------------------------------------------------------------------- C_elegans_F33H2.3 ----------------------------------------------------------AAGDDE------------------------------------------- C_elegans_T19H12.2 ----------------------------------------------------------SA---E------------------------------------------- A_aegypti_AAEL012656-PD ----------------------------------------VSFQTSEWIGLRQKVPTKRLISYSL------------------------------------------ A_gambiae_AGAP007670-PB ----------------------------------------INY---------------------------------------------------------------- A_aegypti_AAEL006840-PA ----------------------------------------VSFQTSEWIGLRQK----------------------------------------------------- D_melanogaster_FBpp0088015 ----------------------------------------QNGAGHNGSGAVAMEY--------------------------------------------------- T_nigroviridis_ENSTNIP00000009472 ----------------------------------------VDGA--------------------------------------------------------------- T_rubripes_ENSTRUP00000000150 ----------------------------------------AHMAGDLGEGMSERGGNVDEDIEDAVLVARNQEAMEASRRRMQEELDAKAVVFREKQKEKEEERRKE G_gallus_ENSGALP00000011598 ----------------------------------------PTGS--------------------------------------------------------------- A_carolinensis_ENSACAP00000003100 ----------------------------------------ANGS--------------------------------------------------------------- C_elegans_F43G6.3 ----------------------------------------SRIFDQLWRNFALDRCLTSRGTLY------------------------------------------- T_guttata_ENSTGUP00000009232 ----------------------------------------PNGS--------------------------------------------------------------- C_intestinalis_ENSCINP00000011422 ----------------------------------------GANIKPVLPPIPTGGR--------------------------------------------------- P_pygmaeus_ENSPPYP00000021193 ----------------------------------------PLI---------------------------------------------------------------- T_rubripes_ENSTRUP00000025664 ----------------------------------------KLQFLTSLSELSLIDNPVDSSSLYRPSVLLRLPLLKVLDGERVTLEDRARVELLNVEETVRTALN-- M_mulatta_ENSMMUP00000020530 ----------------------------------------PLI---------------------------------------------------------------- B_taurus_ENSBTAP00000018076 ----------------------------------------ANGS--------------------------------------------------------------- E_caballus_ENSECAP00000017313 ----------------------------------------TNGS--------------------------------------------------------------- O_anatinus_ENSOANP00000018632 ----------------------------------------TNGS--------------------------------------------------------------- M_domestica_ENSMODP00000015061 ----------------------------------------ANGS--------------------------------------------------------------- G_aculeatus_ENSGACP00000013527 ----------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000032723 ----------------------------------------TNGS--------------------------------------------------------------- R_norvegicus_ENSRNOP00000016758 ----------------------------------------TNGS--------------------------------------------------------------- C_familiaris_ENSCAFP00000015542 ----------------------------------------TNGS--------------------------------------------------------------- H_sapiens_ENSP00000254193 ----------------------------------------TNGS--------------------------------------------------------------- M_mulatta_ENSMMUP00000015518 ----------------------------------------TNGS--------------------------------------------------------------- P_pygmaeus_ENSPPYP00000007744 ----------------------------------------TNGS--------------------------------------------------------------- P_troglodytes_ENSPTRP00000041754 ----------------------------------------TNGS--------------------------------------------------------------- H_sapiens_ENSP00000250173 ----------------------------------------PLI---------------------------------------------------------------- P_troglodytes_ENSPTRP00000035210 ----------------------------------------PLI---------------------------------------------------------------- R_norvegicus_ENSRNOP00000037753 VARKGLGDMAVSSSVGRDGVEWGWSLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV E_caballus_ENSECAP00000002990 ----------------------------------------PLI---------------------------------------------------------------- G_gorilla_ENSGGOP00000008764 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