>H_sapiens_ENSP00000386496 -------M----EM-----------GR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000007477 -------------M-----------GR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_aculeatus_ENSGACP00000022373 -------M----EM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTTVSH-------------------------LPRLNKLKK--L ELS-------DNRI--SGGLEVLAAKCPNLTHLNLSGNKIKDLSTIEPLKELATLKSLDL ------FNCE-VTNLNEYRDNVFKLLPQLTYLDGY------DKD--DK------------ -EAP-----------------------------D--SDAE--VYA--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DEDD-----------------DEDGDEEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EGEDDD----------------------------- -------------E-EENEEGE-------------------------------------- ------------------------------------------------------------ -----------EEE-EV--SG--------------------------------------- -------------------------------------------------EKEE------- --------------EEEDLN-DKE----------ADDE---------------------- ---------------------DD------------------EGE-------------LK- -------EVEQGQKRKRELDEE-G-E---------------------------------- ------------------------------------------------------------ ------------EDEDD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >C_familiaris_ENSCAFP00000025783 -------M----DM-----------DK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSIEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EED-------------VG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_troglodytes_ENSPTRP00000039448 -------------M-----------GR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-S---------RSNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE---YV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >A_carolinensis_ENSACAP00000013586 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLEKLENLKSLDL ------FNCE-VTNLNDYRDNVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEDEED---------------GESFPKDAM--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------NFDEED----------------------------- -------------E-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------EE------------------EEE-----------A-AA- -------EEERGEKRKREADDE-G-D---------------------------------- ------------------------------------------------------------ ------------EED--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gallus_ENSGALP00000013053 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSYEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLASVAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLGTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDDDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGD----------VDDD---------------------- ---------------------ED------------------EEE--------------P- -------DEERGQKRKREPEDE-G-D---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >D_rerio_ENSDARP00000022360 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVTN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAGKCPNLTHLNLSGNKIKDLSTIEPLKKLESLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DKE--DK------------ -EAP-----------------------------D--SDAE--AYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EDDEED------------EGEEEDYDEDAA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PGEEDE----------------------------- ----------EEGE-EDDEEEG-------------------------------------- ------------------------------------------------------------ --------EEEEEE-DI--SG--------------------------------------- -------------------------------------------------EEE-------- --------------EEEELN-DGE----------VDDE---------------------- ---------------------ED-----------------------------------F- -------EEERGLKRKRELDEE-G-E---------------------------------- ------------------------------------------------------------ ------------EDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >X_tropicalis_ENSXETP00000017086 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --A-DVKELV-LDN-C---------RSKEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEGLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVCLSSIAN-------------------------LPKLNKLKK--L ELS-------DNNI--SGGLEVLAEKCPNLTHLNLSGNRIKDLSTIEPLKKLEHLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DDDEED---------------EDDYDEDAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PGEEGE----------------------------- -------------D-DEDEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-EV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEDAYR-EGE-----------EDE---------------------- ---------------------AD------------------E------------------ -------EAEHGQKRKREQDDD-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_domestica_ENSMODP00000034651 -------P----SS-----------PH--------------------------------- -------------------------------------------------SPHFPSHGPFP --L-QVKELV-LDN-C---------RSYDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINAGISSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIDPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDVE--AYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLED----------------- ---------------------------DEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVLPLE----------------------------- -------------R-RKFSSGK-------------------------------------- ------------------------------------------------------------ -----------RVL-EE--NI--------------------------------------- -------------------------------------------------GLEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EDE-------------VG- -------EEEKGQKRKREPEDG-G-D---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >H_sapiens_ENSP00000329250 -------M----EM-----------GR--------------------------------- -------------------------------------------------RIHSELRNRAP --S-DVKELA-LDN-S---------RSNEGKLEA-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSKINGGLTSISD-------------------------LPKL-KLRK--L EL----------RV--SGGLEVLAEKCPNLTHLYLSGNKIKDLSTIEPLKQLENLKSLDL ------FNCE-VTNLNDYGENVFKLLLQLTYLDSC------YWD--HK------------ -EAP-----------------------------Y--SDIE--DHV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEGEH---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------G-EEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------GDEE------- --------------DEEGYN-DGE----------VDGE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_guttata_ENSTGUP00000010000 -------M----EM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSYEGKIVG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------YLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELG-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKLKDLGTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAPDSDAEGYVEELDDKEEDEDVKDRDDKEAPD--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDDDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------DEEEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE--------------P- -------EEERGQKRKREPEDE-G-D---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_anatinus_ENSOANP00000021355 ------------------------------------------------------------ --------------------------------------------------YHMNLYFCLP LAR-RLKSFV-LDN-C---------RS-KGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELS-------DNRL--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DDEEDE---------------DGAYPADQ---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GDQT----------------------------- -------------R-RGRASRT-------------------------------------- ------------------------------------------------------------ -----------LLA-EV--QK--------------------------------------- -------------------------------------------------DPRE------- --------------DEEGYN-DGE----------VDDD---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-D---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >B_taurus_ENSBTAP00000016410 ------------------------------------------------------------ -----------------------------------------------------------P --S-QVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >E_caballus_ENSECAP00000002350 ------------------------------------------------------------ -----------------------------------------------------------P --F-QVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EEEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EED-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_nigroviridis_ENSTNIP00000012431 -------M----DM-----------RK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTTVAH-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKDLGTLKSLDL ------FNCE-VTNLNEYRDSVFKLLPQLTYLDGY------DKD--DK------------ -EAP-----------------------------D--SDAE--VYA--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EDDDED---------------GKVENKELE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LCADVD----------------------------- -------------E-EEYDEDA-------------------------------------- ------------------------------------------------------------ -----------APG-DL--SG--------------------------------------- -------------------------------------------------EEE-------- --------------EEEDLN-DRE----------VDDE---------------------- ---------------------DE------------------EGE-------------VP- -------EEERGQKRKRELDEE-G-E---------------------------------- ------------------------------------------------------------ ------------EDE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_mulatta_ENSMMUP00000029913 ------------------------------------------------------------ ------------------------------------------------------------ -----VKELV-LDN-S---------RSNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNDYRENVFKLLPQLTYLDGY------DRD--DK------------ -EAP-----------------------------D--SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------D-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_musculus_ENSMUSP00000082652 -------M----EM-----------DK--------------------------------- -------------------------------------------------RIYLELRNRTP --S-DVKELV-LDN-C---------KSIEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSISN-------------------------LPKLNKLKK--L ELS-------ENRI--SGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNAYRENVFKLLPQVMYLDGY------DRD--NK------------ -EAP-----------------------------D--SDVE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------DD----------------- ---------------------------DEEDED---------------EEEYDEYAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LVEDEE----------------------------- -------------E-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EEE-------------AG- -------EEEGSQKRKREPDDE-G-E---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gorilla_ENSGGOP00000015042 -------------M-----------GR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-S---------RSNEGKXEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLXTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLXXLDL ------FNCE-VTNLNDYREXVFKLLPQLTYLXGY------DRD--DK------------ -EAP--------------------------------SDAE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEDED---------------XXXXXXXXX--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------XXXXXX----------------------------- -------------X-XXXXXXX-------------------------------------- ------------------------------------------------------------ -----------XXX-XX--XX--------------------------------------- -------------------------------------------------XXXX------- --------------XXXXXX-XXX----------XXXX---------------------- ---------------------XX------------------XXX-------------XX- -------XXXXXXKRKXEPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_rubripes_ENSTRUP00000042944 PGPRRSRM----LM-----------RR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTTVAH-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLEVLVEKCPNLTHLNLSCNKIEDLSTIEPLKELGTLKSLDL ------YNCE-VTNLSEYRDSVFKLLPQLTYLDGY------DKD--DK------------ -EAP-----------------------------D--SDSE--VYA--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EDDDED--------------DEEEYDEDAA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PGDEEE----------------------------- -------------D-EGDEDEE-------------------------------------- ------------------------------------------------------------ -----------DED-DL--SG--------------------------------------- -------------------------------------------------EEE-------- --------------EEEDLN-DRE----------VDDE---------------------- ---------------------DE------------------E------------------ -------EEERGQKRKRELDEE-G-E---------------------------------- ------------------------------------------------------------ ------------EDEDD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_domestica_ENSMODP00000003980 -------V----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLISVGLSTVSN-------------------------LPELPKLKK--L ELS-------DNRI--FGGLDVLAEKLPNLTHLNLSGNNLKDISTLEPLKKLEYLKSLDL ------FNCE-VTNLNDYRESVFTLLPQLTYLDGY------DQE--DK------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDD----------------- ---------------------------EGEFEN---------Y-----NEEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------D-EEDE-F--------------------------- --------DEEDDDEE-DDVEG-------------------------------------- ------------------------------------------------------------ ----------DDYEYDV--SG--------------------------------------- -------------------------------------------------E---------- --------------EEEFGH-DGE----------VDDD---------------------- ---------------------EE------------------DEE-------------DE- -------ETGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------GE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_latipes_ENSORLP00000002331 -------M----EM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVKELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTTVAH-------------------------LPKLKKLKK--L ELS-------DNRI--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIGPLKELGALKSLDL ------FNCE-VTNLNEYRDNVFKLLPQLTYLDGY------DKD--DK------------ -EAP-----------------------------D--SDGE--VYA--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------DEDDEE--------------DEEEYDEDAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PGEEEEDD--------------------------- -------LNDKEGD-DDDEEEG-------------------------------------- ------------------------------------------------------------ -----------EQNAHV--RH--------------------------------------- -------------------------------------------------LELE------- --------------EERGQKRKRE----------LDEE---------------------- ---------------------GE------------------EDD-----------D-DL- -------DEERGQKRKRELDEE-G-E---------------------------------- ------------------------------------------------------------ ------------EDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_nigroviridis_ENSTNIP00000013976 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVQELV-LDN-C---------RSTEGKIVG-------------------------- ------------------------------------------------------------ ---------------L---------------------TEEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLTSVFN-------------------------LPKLEKLKK--L ELS-------DNRI--SSGLDVLAVKLPNLRHLNLSGNKLKDISTLEPLKKLENLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DIE--DR------------ -EAS-----------------------------D--SDGE--VDG--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GIYD----------------- ---------------------------DED------------------EEGEEEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEED-F--------------------------- -------DEEEDDEEDEEEVEG-------------------------------------- ------------------------------------------------------------ ----------EEDDDEV--SG--------------------------------------- -------------------------------------------------EDE-------- --------------EEEFGQ-DGE----------VDEE---------------------- ---------------------DE------------------DED--EDDD-------EA- -------EAGKGEKRKRDPEDE-D-D---------------------------------- ------------------------------------------------------------ ------------EDDDEDDD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gallus_ENSGALP00000002398 -------M----EM-----------KK--------------------------------- -------------------------------------------------RLTLELRNKKP --G-EVKELV-LDN-C---------RSDDGKIVG-------------------------- ------------------------------------------------------------ ---------------L---------------------SSDFENLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMINVNLLSISN-------------------------LPKLNKLRK--L ELS-------DNRI--SGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDL ------FNCE-VTMLINYRESVFTLLPQLTYLDGF------DAD--EQ------------ -EAP-----------------------------D--SDPE--ADG--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLED----------------- ---------------------------EYENGE--------------GEEEEDDDEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DDLDEE----------------------------- --------VIDEEDDEDDDLEG-------------------------------------- ------------------------------------------------------------ ----------EEEEDGV--DD--------------------------------------- -------------------------------------------------E---------- --------------EEDEEE-DGE----------DEED---------------------- ---------------------DE------------------ADD---------------- -------DLPRGEKRKRNLEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EDPEDEEDDEDD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >X_tropicalis_ENSXETP00000022463 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVRELV-LDN-C---------RAHEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVLLMSVSN-------------------------LPKLPKLKK--L ELS-------DNRI--SGGLDVLAEKLSNLTHLNLSGNKIKDISTLEPLKKLESLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DK------------ -EAP-----------------------------D--SDAE--ADG--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEEDEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EGEEEEDV--------------------------- -------DEEEDDDEDEEEIGE-------------------------------------- ------------------------------------------------------------ ----------EEDEEDA--SG--------------------------------------- -------------------------------------------------EEE-------- --------------EEDFGH-DGE----------VDED---------------------- ---------------------DD------------------EED--DEED---E-E-EE- -------ESGKGEKRKRETDDD-G-D---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >R_norvegicus_ENSRNOP00000020443 -------L----IL-----------TQ--------------------------------- -------------------------------------------------KQVKRVTNCRP --F-KVKELV-LDN-C---------RSIEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSISN-------------------------LPKLNKLKK--L ELS-------ENRI--SGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-VTNLNAYRENVFKLLPQVMYLDGY------DRD--NK------------ -EAP-----------------------------D--SDVE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------DD----------------- ---------------------------DEEDED---------------EEEYDEYAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LVEDEE----------------------------- -------------E-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------EEEE------- --------------DEEGYN-DGE----------VDDE---------------------- ---------------------ED------------------EED-------------AA- -------EEEGSQKRKREPDDE-G-E---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_latipes_ENSORLP00000008884 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVRELV-LDN-C---------RSIEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLAKLKK--L ELS-------DNRI--SGGLDVLAEKLPHLTHLNLSGNKLKDLSTLEPLKKLDNLKSLDL ------FNCE-VTNLNDYRDSVFKLLPQLTYLDGY------DIA--DR------------ -EAS-----------------------------D--SDGE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDD----------------- ---------------------------DEDYFK---------KIYGCFTDGEEEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEED-F--------------------------- -------DEEEEDEEDEEEVEG-------------------------------------- ------------------------------------------------------------ ----------EDDDEEV--SG--------------------------------------- -------------------------------------------------EDEVNFVSSK- --------------EEEFGQ-DGE----------VEDE---------------------- ---------------------DE------------------DED--EDEE---G-M-QA- -------EAGKGEKRKRDPEDE-D-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_troglodytes_ENSPTRP00000028434 -------M----EM-----------GR--------------------------------- -------------------------------------------------RIHSELRNRAP --S-DVKELA-LDK-S---------RSNEGKLEA-------------------------- ------------------------------------------------------------ ---------------L---------------------TEEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINGGLTSISD-------------------------LTKL-KLRK--L EL----------RV--SGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKQLENLKSLDL ------FNCK-VTNLNDFRENVFKLLLQLTYLDSC------YWD--HK------------ -EAP-----------------------------D--SDIK--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EEEGED---------------EEEYDEDAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VVEDEE----------------------------- -------------G-EDEEEEG-------------------------------------- ------------------------------------------------------------ -----------EEE-DV--SG--------------------------------------- -------------------------------------------------GEEE------- --------------DEEGYN-DGE----------VDGE---------------------- ---------------------ED------------------EEE-------------LG- -------EEERGQKRK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >A_carolinensis_ENSACAP00000004238 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --P-DVQELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SGEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLASVLN-------------------------LPKLPKLKKDDL ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDIGTLEPLKKLDSLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DQE--DK------------ -EAS-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EDEEGE---------A-----SEEEEEEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEE---DED-EEGEG-------------------------------------- ------------------------------------------------------------ ---------EEDEEDEI--SG--------------------------------------- -------------------------------------------------E---------- --------------EEEFGR-DGE-------------E---------------------- ---------------------ED------------------EEE--EEED---E-D-EE- -------ESGKGEKRKREADDE-G-D---------------------------------- ------------------------------------------------------------ ------------ED---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >D_rerio_ENSDARP00000033105 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVRELV-LDN-C---------RSNEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLLSVSN-------------------------LPKLGKLKK--L ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDHLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DLD--DR------------ -EAS-----------------------------D--SDGE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDD----------------- ---------------------------DDD------------------EEGEDED----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EEED-F--------------------------- -------DEEEDEDDDEDEVEG-------------------------------------- ------------------------------------------------------------ ----------EEDDEDG--SG--------------------------------------- -------------------------------------------------EDE-------- --------------EEDFGQ-DGE----------VEDD---------------------- ---------------------EE------------------DDD--DDDD---E-E-EE- -------QGAKGEKRKREADDE-D-D---------------------------------- ------------------------------------------------------------ ------------EDDEEDD----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000005024 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------DNRI--YGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDCLKSLDL ------FNCE-VTNLNDYRESVFRLLPQLTYLDGY------DRE--DR------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEEEDEDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------EEDEDEV--SG--------------------------------------- -------------------------------------------------E---------- --------------EEEFGH-DGE------------------------------------ -----------------------------------------DED--EDED---E-E-EE- -------ESGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >A_carolinensis_ENSACAP00000007900 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRNRAP --E-KVTELV-LDN-C---------RSSNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELTSLAK-------------------------LPALNKLRK--L ELS-------DNLI--SGGLEVLAERCPNLTYLNLSGNKIKDLSTVESLQNLKNLKSLDL ------FNCE-ITKPKDYRESVFELLQQITYLDGF------DQD--DN------------ -EAP-----------------------------D--SEDE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------EDEED----------------EDKAGPPGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEN------------------------------- ---------------DEEDDDA-------------------------------------- ------------------------------------------------------------ ---------SDLGEVEG--EE--------------------------------------- -------------------------------------------------EEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EER--ENE-----EE-EA- -------EALRGEKRKRAAEDE-G-D---------------------------------- ------------------------------------------------------------ ------------EDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_mulatta_ENSMMUP00000016055 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEE--DDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------DEDDDEV--SE--------------------------------------- -------------------------------------------------E---------- --------------EEEFGL-DEE------------------------------------ -----------------------------------------DED--EDED---E-E-EE- -------EGGKGEKRKRETDDE-G-D---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >H_sapiens_ENSP00000345848 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEDDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEE--DDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------DEDDDEV--SE--------------------------------------- -------------------------------------------------E---------- --------------EEEFGL-DEE------------------------------------ -----------------------------------------DED--EDED---E-E-EE- -------EGGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000021773 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEE--DDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------DEDDDEV--SE--------------------------------------- -------------------------------------------------E---------- --------------EEEFGL-DEE------------------------------------ -----------------------------------------DED--EDED---E-E-EE- -------EGGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_troglodytes_ENSPTRP00000036180 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DEE--DDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------DEDDDEV--SE--------------------------------------- -------------------------------------------------E---------- --------------EEEFGL-DEE------------------------------------ -----------------------------------------DED--EDED---E-E-EE- -------EGGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >D_rerio_ENSDARP00000071527 -------M----EM-----------KK--------------------------------- -------------------------------------------------RISLELRNRTP --A-EVAELV-VDN-C---------RSSDGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDDFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMVNVGLTSLAK-------------------------LPSLPKLRK--L ELS-------DNNI--SGTLETLAEKCANLTYLNLSGNKIKELSTLEALQNLKNLKSLDL ------FNCE-ITTLEDYRESIFELLPQVTYLDGF------DAE--DN------------ -EAP-----------------------------D--SEAD--DDD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DDEDG----------------DEGAGQLGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEE------------------------------- ---------------EEEDEEG-------------------------------------- ------------------------------------------------------------ ---------SEGG----------------------------------------------- ----------------------------------------------------EVGLSYL- --------------MKEDIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEE-EEEG-----GE-EE- -------ADVRGEKRKREAEDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDDEDDD----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_rubripes_ENSTRUP00000019528 -------M----DM-----------NK--------------------------------- -------------------------------------------------RVNLELRHRPP --S-EVKELV-LDN-C---------RSDDGKIEG-------------------------- ------------------------------------------------------------ ---------------I---------------------TAEFSNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LLSLINVGLSSVAE-------------------------IPKLDKLKK--L ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL ------FNCE-VTNLGDYRESIFKLLPQLTYLDGY------DID--DC------------ -EAS-----------------------------D--SDGE--G----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------IVDD----------------- ---------------------------EDDEG----------------EREAPSGGR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------NGESED-F--------------------------- -------EDEEEEDDE-EVVAE-------------------------------------- ------------------------------------------------------------ ----------EEEDESG--ED--------------------------------------- -------------------------------------------------EDG-------- --------------EVNGDL-DSE----------DEED---------------------- ---------------------EE------------------EED--EDE----D-E-DS- -------TAAKGEKRKRDVEDE-G-D---------------------------------- ------------------------------------------------------------ ------------DDEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_anatinus_ENSOANP00000017079 -------F----IF-----------EK--------------------------------- -------------------------------------------------KLHLFLGTRTP C-A-QVKELV-LDN-C---------RSDEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVVLISVSN-------------------------LPKLPKLRK--L ELS-------DNRI--FGGLDVLAERLPNLTHLNLSGNKLKDISTLEPLKKLVFLKSLDL ------FNCE-VTNLNDYRENVFSLLPQLTYLDGY------DRD--DR------------ -EAQ-----------------------------K--RRED--RGT--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GIKN----------------- ---------------------------EGSGESG--------------FLQDKQNKE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AGKDGI----------------------------- -----------SGDVEDILHKG-------------------------------------- ------------------------------------------------------------ ---------QIIFE---------------------------------------------- ---------------------------------------------------EPAGISEV- --------------EEEDFE-HQSWETKPVINFGVDSD---------------------- ---------------------ED------------------DVD-------------EE- -------ETGRGEKRKRESDDD-G-D---------------------------------- ------------------------------------------------------------ ------------EE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_aculeatus_ENSGACP00000024521 -------M----DM-----------KK--------------------------------- -------------------------------------------------RVSLELRHRSP --T-EVQELV-LDN-C---------RSGEGKIEG-------------------------- ------------------------------------------------------------ ---------------I---------------------TEEFSNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LLSLINVGLTSVAD-------------------------IPKLDKLKK--L ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL ------FNCE-VTNLADYRESIFKLLPQLTYLDGY------DID--DC------------ -EAS-----------------------------D--S----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >B_taurus_ENSBTAP00000028486 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------DNRI--CGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DR------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEDDEE---------G-----EDEDKEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DDEEDDDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------EEDEDEV--SG--------------------------------------- -------------------------------------------------E---------- --------------GEKAGN-IGE----------RSDF---------------------- ---------------------NP------------------NEDLVKDQD---R-E-EE- -------ESGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_anatinus_ENSOANP00000020934 -------E----EL-----------KA--------------------------------- -------------------------------------------------RIHPLIVTALC --P-QVKELV-LDN-C---------RSEDGRIVG-------------------------- ------------------------------------------------------------ ---------------L---------------------SSDFDSLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMININLLSVSN-------------------------LPKLSRLRK--L ELS-------DNRI--CGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLRSLDL ------FNCE-VTMLINYRESMFGLLPQLTYLDGF------DAD--DQ------------ -EAP-----------------------------D--SDPE--VDG--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDD----------------- ---------------------------EYDENGEG-------------EELWDECVG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LMDSGF----------------------------- ---------SLPLQDEDEDEDG-------------------------------------- ------------------------------------------------------------ ----------EDDEDE-------------------------------------------- -------------------------------------------------DGEEVGLSPF- --------------MSLPLP---------------------------------------- ---------------------------------------------------------AP- -------DHPQGEKRKRDLEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EDP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >X_tropicalis_ENSXETP00000034315 -------M----EM-----------KK--------------------------------- -------------------------------------------------RISLELRNRNP --S-EVAELV-LDN-C---------RSVDGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTYKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELKSLSK-------------------------LPKLPKLRK--L ELS-------DNSI--SGGLDVLTERCPNITYLNLSGNKIKDLSTVESLANLKNLKSLDL ------FNCE-ITNLEDYRENIFQRLSQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEED--DDD--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------EYEY----------------- ---------------------------D---------------------DEEPGPRG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEE------------------------------ ---------------DEDEEGA-------------------------------------- ------------------------------------------------------------ ---------SDLGDEEE--EE--------------------------------------- -------------------------------------------------EEEEVGLSYL- --------------MKEEIR-DEE----------DDDD---------------------- ---------------------YV------------------EDGAEGEE-----EE-EED EEDEAAAAADRGEKRKRDPEDD-G-D---------------------------------- ------------------------------------------------------------ ------------EDED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >R_norvegicus_ENSRNOP00000043155 -------M----EK-----------DK--------------------------------- -------------------------------------------------QIYLELQNRTP --S-DVKELV-LDN-C---------QSTEGKMEG-------------------------- ------------------------------------------------------------ ---------------F---------------------MDEFEELK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVDLTSILN-------------------------LPKLSKLKK--L ELS-------ENRI--SGDLEVLAEKCLNLKHLNLSGNKIKDPSAIEPLRKLENLKSLDL ------FKCE-VTNLTAYQENEFKLLPEVMCLDGY------DRD--NK------------ -EAP-----------------------------D--SDVE--GYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------DEDN----------------- ---------------------------EENE-----------------DEENDEYAQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LVLEEE----------------------------- -----------------DEEGG-------------------------------------- ------------------------------------------------------------ -----------EEE-NV--SG--------------------------------------- -------------------------------------------------EEEDE------ --------------EEEGYN-TG-----------LDDE---------------------- ---------------------ED------------------EDD--------AG-E-ET- -------ERERDRDRDRETERQ-R-D---------------------------------- ------------------------------------------------------------ ------------T----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000000076 ------------------------------------------------------------ ------------------------------------------------------------ -----VKELV-LDN-C---------RSNEGKIEA-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLVSVAN-------------------------LPKLNKLKK--L ELS-------DNRI--SGGLDVLAEKCPTLTHLNLSGNKIKDLSTIEPLKKLENLKSLDL ------FNCE-MTNLNDYRENVFELLPQLTYLDSY------DRD--DK------------ -EAS-----------------------------D--SDAE--SYV--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------SLDD----------------- ---------------------------EEEDED--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_aculeatus_ENSGACP00000022955 -------M----DM-----------KK--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVRELV-LDN-C---------RSVEGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLMSVSN-------------------------LPKLAKLKK--L ELS-------DNRI--SGGLDVLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDNLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DTE--DR------------ -EAS-----------------------------D--SDGE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDD----------------- ---------------------------DED------------------EEGEEEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEED-F--------------------------- -------DEEEDDEEDEEEVEG-------------------------------------- ------------------------------------------------------------ ----------EDDD-EV--SG--------------------------------------- -------------------------------------------------EDE-------- --------------EEDFAQ-DGE----------VDDE---------------------- ---------------------D-------------------DDD--EDEE---E-A-EA- -------EAG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_latipes_ENSORLP00000025080 -------M----DM-----------NK--------------------------------- -------------------------------------------------RVSLELRHRSP --S-EVHELV-LDN-C---------RSGDGKMEG-------------------------- ------------------------------------------------------------ ---------------I---------------------TEEFSNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSLINVGLTSMAG-------------------------IPKLDKLKK--L ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL ------FNCE-VTNLADYRDSIFKLLPQLTYLDGY------DVN--DR------------ -EAS-----------------------------D--SEGE--G----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDD----------------- ---------------------------EGEEG----------------EEGGAKTQR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SA--------------------------------- -------------DDE-KCLSG-------------------------------------- ------------------------------------------------------------ ----------FPVGRRG--QR--------------------------------------- -------------------------------------------------RCGQQP----- --------------EVQQEM-MSS----------GKEN---------------------- ----------------------L------------------IIF--PSA----D-E-DS- -------SPVKGEKRKRDPEDE-D-E---------------------------------- ------------------------------------------------------------ ------------EED--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_latipes_ENSORLP00000001658 -------M----DM-----------KK--------------------------------- -------------------------------------------------RITLELRNRSP --A-EIVELV-LDN-S---------RSADGEVEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFTELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMVNVGLSSLTK-------------------------LPPLPKLRK--L ELS-------DNNL--SGSLETLAEKCPNLTYLNLSGNKIKELSTLEALQNLKSLQSLDL ------FNCE-ITSLEDYRESVFELLPQVTYLDGF------DQE--DN------------ -EAP-----------------------------D--SEAD--DED--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------DEG----------------EEGAGPTGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YDDE------------------------------- -------------EDEEDDEDG-------------------------------------- ------------------------------------------------------------ ---------SEGGE---------------------------------------------- ------------------------------------------------------------ -----------------EEY-NEE----------DDD----------------------- ----------------------------------------------AEE-----ED-DQ- -------AGAPG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_domestica_ENSMODP00000004440 -------M----DI-----------KR--------------------------------- -------------------------------------------------RLTLELRNRKP --G-EVKDLV-LDN-C---------SSEDGKIGG-------------------------- ------------------------------------------------------------ ---------------L---------------------SSEFENLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMISINLVSLAN-------------------------LPKLPRLQK--L ELS-------DNLI--SGGLEVL-ERTPSLVQLNLSRNKIKDINTLEPLKKLPNLKSLDL ------FNCD-VTMLMSYRESVFGLLPQLTYLDGY------SAD--DK------------ -EAP-----------------------------D--SDPE--ADR--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDK----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------PQHGEKRKRATDDE-G------------------------------------ ------------------------------------------------------------ ------------EDSEDEEED--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >E_caballus_ENSECAP00000006868 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDAFKKLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEDEE----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------E---EDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------EGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_rubripes_ENSTRUP00000027152 -------M----EM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --S-DVRELV-LDN-C---------RSTEGKIQG-------------------------- ------------------------------------------------------------ ---------------L---------------------TEEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLVSVAN-------------------------LPKLAKLKK--L ELS-------DNRI--SSGLDVLAEKLPNLRHLNLSGNKLKDMSTLEPLKKLENLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DIE--DR------------ -EAS-----------------------------D--SDGE--VDG--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GTDD----------------- ---------------------------DEDEGK---------D-----PEGEEEDDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEED-F--------------------------- -------DEEEDDEEDEEEVEG-------------------------------------- ------------------------------------------------------------ ----------EEDDDEV--SG--------------------------------------- -------------------------------------------------EDE-------- --------------EEDFAQ-DGE----------VDEE---------------------- ---------------------DD------------------DDD--DEDDEEFH-K-EA- -------DAGKGEKRKRDPEDE-D-D---------------------------------- ------------------------------------------------------------ ------------ED---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gorilla_ENSGGOP00000011344 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLXXXXXXXXXXXX-------------------------XXXXXXXXX--L ELS-------ENRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEX---------X-----XXXXXXXXX--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------XXXXXX-X--------------------------- -------XXX--XXXX-XXXXX-------------------------------------- ------------------------------------------------------------ ----------XXXXXXX--XX--------------------------------------- -------------------------------------------------X---------- --------------EEEFGL--EE------------------------------------ -----------------------------------------DED--XDED---E------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gallus_ENSGALP00000040136 -------M----EM-----------EK--------------------------------- -------------------------------------------------RINLELRNQAP --RGDVTELV-LDN-C---------KSSNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDSFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVQLTSLAK-------------------------LPTLSKLRK--L ELS-------DNII--SGGLEVLAERCPNLTYLNLSGNKIKDLGTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRDSIFDLLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEDD--DDE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DNDED----------------EDEAGPPGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEE------------------------------- ---------------DDEDDGG-------------------------------------- ------------------------------------------------------------ ---------SDLGE-----GE--------------------------------------- -------------------------------------------------EEEEVGLSYL- --------------MKEEIQ-DED----------DDDD---------------------- ---------------------YV------------------EEG--GDE-----EE-EA- -------EGIRGEKRKRDPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >C_familiaris_ENSCAFP00000003588 ------------------------------------------------------------ ------------------------------------------------------------ -----VRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------DNRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLEYLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DR------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DDEEDEDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------EEDEDEV--SG--------------------------------------- -------------------------------------------------EVGANVFAALF PICRRKQ-------EEEFGH-DGE----------VDED---------------------- ---------------------ED------------------DED--EDED---E-E-EE- -------ESGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDKTPNNLQRKNC----------------------------------- ------------------------------------------------------------ ----------------------------------------SPLLEIHHQAWGL-PHKIVS VVRFSCQTCCSV----------------------------------- >R_norvegicus_ENSRNOP00000028744 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINMELKNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE-EEDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------EEDEE----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------Y---------------------------------- -----------EDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SEVGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------DEG-EEEE-----EE-EE- -------EGPRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_musculus_ENSMUSP00000015893 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINMELKNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEEDDDDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------EEDED----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEE------------------------------- -------------EDDDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SEVGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKDEIQ-DEE----------DDDD---------------------- ---------------------YV------------------DEG-EEEE-----EE-EE- -------EGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000005451 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAQ-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRGSIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------D-DEE----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FEEEEEEE--------------------------- -------E---EDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SEVGE---------------------------------------------- -------------------------------------------------G-EEVGLSFL- --------------MKDEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----DE-EE- -------ECLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_musculus_ENSMUSP00000083521 -------M----DM-----------KR--------------------------------- -------------------------------------------------RIHLELRNRTP --A-AVRELV-LDN-C---------KAMDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLISVGLFSVSD-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDL ------FGCE-VTNRSDYRETVFRLLPQLSYLDGY------DRE--DQEAPDSDVEVDSV EEAP-----------------------------D--SDGE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDK----------------- ---------------------------EEEDEE---------G-----EDEEEEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-D--------------------------- -------EDEEDEDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------EDDEDEV--SG--------------------------------------- -------------------------------------------------EVNTTVF---F PICVKTK-------EEEFGH-DGE----------VDED---------------------- ---------------------EE------------------DED--EDED---E-E-EE- -------ESGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------EPKNSSRDIPPSS----------------------------------- ------------------------------------------------------------ ----------------------------------------VSPLVIHHQAWGLRPNKIVN VVRFSCKTLAVS----------------------------------- >X_tropicalis_ENSXETP00000021012 -------M----EM-----------KK--------------------------------- -------------------------------------------------RLMLELRNRKA --A-DVKELV-LDN-C---------RSDDGKIIG-------------------------- ------------------------------------------------------------ ---------------L---------------------TSEFENLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMINVNLLSVAN-------------------------LPKLPKLKK--L ELS-------DNRI--SGGLEVLAERTPNLTHLNLSGNKIKEINTLEPLKKLPHLMSLDL ------FNCE-VTMLNNYRESVFELLPQLTFLDGF------DAD--DQ------------ -EAP-----------------------------D--SDPE--AED--------------- -L---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EENGEDGED--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DEEDEE----------------------------- -------EFEDELDDEEDDEEG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EDE-------- --------------EGEEEE-EGD----------EEDE---------------------- -----------------------------------------DDE---------------- -------DVPQGEKRKRDLEDD-GDE---------------------------------- ------------------------------------------------------------ ------------EDDDDEEDDE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_aculeatus_ENSGACP00000013165 -------M----DM-----------KK--------------------------------- -------------------------------------------------RITLELRNRSP --A-EIAELV-VDN-S---------RCADGEVDG-------------------------- ------------------------------------------------------------ ---------------L---------------------TEAFTGLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMVNVGLSSLAK-------------------------LPSLPKLHK--L ELS-------DNNL--CGSLGTLSEKCPNLTYLNLSGNKIKELSNVEALQNLKSLQSLDL ------FNCD-ITSLEDYRDSVFELLPQVTYLDGF------DQE--DN------------ -EAP-----------------------------D--SEAD--DEE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EDGAAPAGD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YD--------------------------------- ---------------EDEDEDG-------------------------------------- ------------------------------------------------------------ ---------SEGGG---------------------------------------------- -----------------------------------------------------AGPNRA- --------------DQPPLP-PQN----------SLSL---------------------- ---------------------------------------------SPAC-----PE-EQ- -------PGVQREKRKRDVDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DDGDEDD----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >C_familiaris_ENSCAFP00000017286 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKKLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------D-EEE----------------EDEAGPPEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------E---EDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------EGLRGEKRKRDAEDD-G-D---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >H_sapiens_ENSP00000324074 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINLELRNRSP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEEEE----------------ENEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------EEEDEDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------GGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_troglodytes_ENSPTRP00000051813 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINLELRNRSP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEEEE----------------ENEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------EEEDEDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------GGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >B_taurus_ENSBTAP00000022237 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRDRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKKLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DE-EE----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------E-----EDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEGEEEEE-----EE-EE- -------EGLRGKR-GNEMLKM-M-E---------------------------------- ------------------------------------------------------------ ------------RKKM-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_rubripes_ENSTRUP00000010444 -------M----DM-----------KN--------------------------------- -------------------------------------------------RVRLELRNRSP --A-EVLELI-LDN-C---------RSTDGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TNEFSELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------YLSLVNVGLGSLAK-------------------------VPSLPKLRK--L DLS-------YNNL--SGSLEKLTEKCPNLTHLNLSGNKIQDLTHLETLQNLKNLRSLEL ------LNCD-ITSVADYRDGVFQLLPQVTYLDGF------DCD--DN------------ -EAS-----------------------------N--SDDD--DDAYE------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------WFCV----------------- ---------------------------SADES----------------EEGAELPAG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YHDEDD----------------------------- -----------EHKDEDDAEVG-------------------------------------- ------------------------------------------------------------ ---------HEGWSFHT--RP--------------------------------------- -------------------------------------------------GHEHIFLFF-- --------------PFNFYY--------------LEDE---------------------- ---------------------EN------------------DE------------E-EV- -------ACTQGQKRKRSEDDE-N-N---------------------------------- ------------------------------------------------------------ ------------ED---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_latipes_ENSORLP00000025809 -------M----EM-----------KK--------------------------------- -------------------------------------------------RISLELRNRSP --T-EVGELV-VDN-C---------RSSDGEVEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SEEFTELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSMVNVGLSSLSK-------------------------MPLLPKLQK--L EVS-------ENSI--GGGLNTLVEKCPGLTHLNLSSNKLKELSSLEPLQSLKALKSLDL ------YGCD-VSSLDDYRERVFQLLPQLTYLDGF------DQE--DN------------ -EAS-----------------------------D--NGEA--PSV--------------- -T---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------HTGS----------------- ---------------------------F-LDE----------------EEEAGPPGD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DDEE------------------------------- --------------DEDDEEHG-------------------------------------- ------------------------------------------------------------ ---------SE------------------------------------------------- --------------------------------------------------EEEVGLSYL- --------------MKDGIQ-EYK----------LADY---------------------- ---------------------FC------------------WSGRDCKQISHVWDQ-YE- -------AAAQGEKRKRDAEDE-G-D---------------------------------- ------------------------------------------------------------ ------------EDED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gorilla_ENSGGOP00000011594 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINLELRNRSP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGSKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEEEE----------------ENEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------EEXDEDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSXL- --------------MKEDIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEXE-----EE-EE- -------GGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEXD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000005091 -------M----EM-----------GK--------------------------------- -------------------------------------------------QIHLELWNRTP --S-DVKELV-LDN-S---------RSNEG------------------------------ ------------------------------------------------------------ -------------------------------------------LE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSITN-------------------------LPRANKLKK--L ELS-------SNRA--SGGLEVLAEKCPNLIHLNLSGNKIKDLSTIEPLKKLENLESLDL ------FNCE-VTNLNDY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_aculeatus_ENSGACP00000004164 -------M----EM-----------KK--------------------------------- -------------------------------------------------RISLELRNRNP --A-DVVELV-VDN-C---------RSSDGEVEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SEEYVALE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSMVNIGLSSLAK-------------------------LPSLPKLRK--L EVS-------DNTI--TGNLEALAETCPNLAYLNLSGNKIKELSSIEPLKSLKNLKSLYL ------YSCE-VSTLDDYTDAVFELLPQLTFLDGY------DHE--DN------------ -EAP-----------------------------D--SEAD--TDD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DDVAGPHGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GEEEVGLSYL- --------------MKEGIQ-DEE----------DDGD---------------------- ---------------------YV------------------KSPFLTDV--------DG- -------ADVQGEKRKRDAEDD-G-D---------------------------------- ------------------------------------------------------------ ------------DDDDE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_rubripes_ENSTRUP00000020657 -------M----EM-----------KK--------------------------------- -------------------------------------------------RISQELGNKNP --A-EVVDLL-VDN-C---------QSGDGEVEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEYTELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSMVNVGLKSLAK-------------------------LPSLPKLRK--L EVS-------DNII--AGGLDTLAEKCPNLTYLNLSGNKIKELKTLKVLQNLKNLRSLDL ------YSCE-VSTLEDYRESVFELLPQLTYLDGF------DQE--DN------------ -EVP-----------------------------D--SEAD--GDGE------CLGMTATS HN---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------RQFV----------------- ---------------------------PPFED----------------EDEAGPVGD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DDDD------------------------------- ---------------DDEDEED-------------------------------------- ------------------------------------------------------------ ---------EDGSD------G--------------------------------------- -------------------------------------------------DEDEVGLSYL- --------------MKEGIQ-DED----------DDGD---------------------- ---------------------YV------------------EEE-EEE---------ED- -------GAFQGEKRKREAEDE-G-D---------------------------------- ------------------------------------------------------------ ------------DDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_nigroviridis_ENSTNIP00000008152 -------M----DM-----------KK--------------------------------- -------------------------------------------------RVVLELRNRPP --S-EVKELV-LDN-C---------RS-NGKVEG-------------------------- ------------------------------------------------------------ ---------------I---------------------TAEFCNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LLSLISVGLCSVAD-------------------------VPKLDKLKK--L ELS-------DNRI--SGGLEVLAERLVNLTHLNLSGNKFKDISTLEPLKKLPQLKSLDL ------FNCE-VTNLGDYRDSIFKLLPQLTYLRGC------ERGLLQR------------ -ESP-----------------------------S--EDED--GEV--------------- -N---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDLD----------------- ---------------------------SEEDED---------------EEDEDEDEV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CAPDE---------------------- ---------------------------------------------------------DP- -------AAAKGEKRKRDVDDD-G-E---------------------------------- ------------------------------------------------------------ ------------DDED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_domestica_ENSMODP00000023408 ------------------------------------------------------------ ------------------------------------------------------------ ----QVTELV-LDN-C---------HSVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMVRVELTSLAQ-------------------------LPSLSKLRK--L ELS-------DNFI--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKSLKSLDL ------FNCE-ITHLQDYRESIFELLQQITYLDGY------DQE--DN------------ -EAP-----------------------------D--SEEE--EDDDE------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GGDD----------------- ---------------------------EEEEG------------------------R--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VHNELLKL--------------------------- -------IISESVKNFVINLNC-------------------------------------- ------------------------------------------------------------ ---------SNLGN---------------------------------------------- ----------------------------------------------------SIQLPFY- --------------LKKLKF-TSE----------YVES---------------------- ---------------------FV------------------KKI-LNNNNNSTFIL-EE- -------ESVQGEKRKRDIEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_guttata_ENSTGUP00000004677 ------------------------------------------------------------ ------------------------------------------------------------ ----QVTELV-LDN-C---------RSSNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDSFKELQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELTSLAK-------------------------LPTLSKLRK--L ELS-------DNVI--SGGLEVLAERCPNLTYLNLSGNKIKDLGTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRDSIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEDD--DDE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------D-DDD----------------ENEAGPPGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEE------------------------------- ---------------DDEDDGA-------------------------------------- ------------------------------------------------------------ ---------SDLGE-----GE--------------------------------------- -------------------------------------------------EEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV-------------------EG--GDE-----EE-EA- -------EGVRGEKRKREPEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EEED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000007165 -------M----KM-----------GR--------------------------------- -------------------------------------------------RIHLD-RNRTP --S-DVKELV-LDN-S---------RLNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDESEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSTINVGLTSIAN-------------------------LPKLNKLKK--L ELS-------DNRV--SGGVEVLAEKCPNLMHLNLSGNKIKDLSTTEPLKKLENLKTLDL ------FNCE-VTNLNDY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >H_sapiens_ENSP00000266594 -------M----EM-----------GK--------------------------------- -------------------------------------------------WIHLELRNRTP --S-DVKELF-LDN-S---------QSNEGKLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFEELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LLNTINIGLTSIAN-------------------------LPKLNKLKK--L ELS-------SNRA--SVGLEVLAEKCPNLIHLNLSGNKIKDLSTIEPLKKLENLESLDL ------FTCE-VTNLNNY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >E_caballus_ENSECAP00000010263 ------------------------------------------------------------ ------------------------------------------------------------ -----VRELV-LDN-C---------KSNDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TAEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLISVSN-------------------------LPKLPKLKK--L ELS-------DNRI--FGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLDCLKSLDL ------FNCE-VTNLNDYRESVFKLLPQLTYLDGY------DRE--DQ------------ -EAP-----------------------------D--SDAE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDE----------------- ---------------------------EEEDEE---------G-----EDEEDEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-F--------------------------- -------DDEEDEDED-EDGEG-------------------------------------- ------------------------------------------------------------ ----------EEDEDEV--SG--------------------------------------- -------------------------------------------------E---------- --------------EEEFGH-DGE----------VDDD---------------------- ---------------------ED------------------DED--EDED---E-E-EE- -------ESGKGEKRKRETDDE-G-E---------------------------------- ------------------------------------------------------------ ------------DD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_guttata_ENSTGUP00000000363 ------------------------------------------------------------ ------------------------------------------------------------ ----QVKELV-LDN-C---------RTEDGKVVG-------------------------- ------------------------------------------------------------ ---------------L---------------------SSDFENLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMININLLSVSN-------------------------LPKLNKLRK--L ELS-------DNRI--SGGLEVLAEKTPNLTHLNLSGNKIKDINTLEPLQHLPNLRSLDL ------STAR-WTMLINYRESVFALLPQLTY-DGF------DAK--KQ------------ -KPH-----------------------------T--QTPE--TEG--------------- -M---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------PL------------------- -------------------------------------------------KMKRDDEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DDLDEE----------------------------- --------VIDDE-DEDDDLEG-------------------------------------- ------------------------------------------------------------ ----------EEGEDGV--DD--------------------------------------- -------------------------------------------------E---------- --------------EEDEEE-DGE----------EDEE---------------------- ---------------------DE------------------AEE---------------- -------DHPCGVKRKRSLEDE-G-E---------------------------------- ------------------------------------------------------------ ------------EDAEDEEDDEDD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >T_nigroviridis_ENSTNIP00000005512 -------M----EM-----------KK--------------------------------- -------------------------------------------------RVSQKLGNKNP --A-EVVELL-VDN-C---------LSGDGEVEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEYTGLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSMVNVGLKSLSK-------------------------LPPLPKLRK--L EVS-------DNVI--AGGLDALSEKCPNLTYLNLSGNKIKELDVLKVLQNLKNLKSLDL ------YSCE-VSTLEDYRDSVFELLPQLTYLDGF------DQE--DN------------ -EVP-----------------------------D--SEPD--GDGEATPPPQCLARRGPA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EQTANVFTE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------DEDEAG-------------------------------------- ------------------------------------------------------------ ---------PVGSE------G--------------------------------------- -------------------------------------------------EEDEVGLSYL- --------------MKEGIQ-DED----------DDGD---------------------- ---------------------YM------------------WRR-------------RP- -------QLFRVRREKRDVEDE-G-D---------------------------------- ------------------------------------------------------------ ------------DDDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >R_norvegicus_ENSRNOP00000056793 ------------DI-----------LI--------------------------------- -------------------------------------------------LLLYENENRLS --S-AVQELV-LDN-C---------KANDGKIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFVNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLINVGLFSVSD-------------------------LPKLPKLKK--L ELS-------ENRI--FGGLDRLAEELPSLTHLNLSGNNLKDISTLEPLKRLDCLKSLDL ------FGCE-VTNRSDYRETVFRLLPQLSYLDGY------DRE--DQEAPDSDVEVDSV EEAP-----------------------------D--SDGE--V----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GVDK----------------- ---------------------------EEEDEE---------G-----EDEEEEEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DGEEEE-D--------------------------- -------EDEEDEDED-EDVEG-------------------------------------- ------------------------------------------------------------ ----------EDDEDEV--SG--------------------------------------- -------------------------------------------------EVN-TLF---F PVGVKAK-------EEEFGH-DGE----------VDED---------------------- ---------------------EE------------------DED--EDED---E-E-EE- -------ESGKGEKRKRETDDE-A-K---------------------------------- ------------------------------------------------------------ ------------EPKNSSRDIPPSS----------------------------------- ------------------------------------------------------------ ----------------------------------------V-PLVIHHQAWGLRPNKIVS VVRFSCKTLAVS----------------------------------- >T_nigroviridis_ENSTNIP00000007469 -------M----DM-----------KN--------------------------------- -------------------------------------------------RIRLELRNRSP --A-EVLELI-LDN-C---------RSADGDLEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TSDFCELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------YLSLVNVGLASLAR-------------------------VPSLPRLRK--L DLS-------YNNL--SASLDKLAEKCPNLTHLNLSGNKIKELTHLETLQNLKNLRSLEL ------LNCD-VTAVAGYRDGVFRLLPHVTYLDGF------DCD--DN------------ -EAS-----------------------------N--SDDD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------DES----------------EEGAGLPGG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YHDEEE----------------------------- -----------EHKDEEEAEVG-------------------------------------- ------------------------------------------------------------ ---------HEGWSFHT--RP--------------------------------------- -------------------------------------------------GRE-------- -----------------FLS--------------REDE---------------------- ---------------------DD------------------EEG------SSPSVE-EA- -------ASTQGQKRKRSEDDE-N-E---------------------------------- ------------------------------------------------------------ ------------D----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000008041 -------M----KM-----------KK--------------------------------- -------------------------------------------------RSNLELRNRAP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------KDTLKQLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELRSLAQ-------------------------LPSLNKLQK--L ELN-------DNII--SGGLEVLAEKCRNLTYLNLSGNKIKDLSTVEALQNLKNFKSLDL ------FNCE-ITNLEDYRGSIFALLQQIMYLDWF------DQE--DN------------ -EAP-----------------------------D--PEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------D-DEK----------------EDEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FEEE------------------------------- ---------------EDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------G-EEVGLSYL- --------------MKDEIQ-D-E----------DDDD---------------------- ---------------------YV----------------------EEEE-----EE-DE- -------EYLLGEKRKRDAEDD-E-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_mulatta_ENSMMUP00000016400 ------------------------------------------------------------ ------------------------------------------------------------ ----QVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEEEE----------------ENEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------EDEDEDEDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------EGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000011938 -------M----EM-----------KK--------------------------------- -------------------------------------------------RINLELRNSAP --E-EVTELV-LDN-C---------LCVSEKIED-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAQ-------------------------IPSLNKLRK--L KLS-------DNII--SGGLEDLAEKCPNLTYLSLSGNKI--LSTVEALQNLKNLKS--L ------FNCE-ITNLEDYRRSIFELLQQITYLVGF------DQG--DN------------ -EAP-----------------------------D--SEEE--DEE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------D-DEE----------------EDQAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FEEEVEEE--------------------------- -----------EDEDEGEDEAG-------------------------------------- ------------------------------------------------------------ ---------SEVGE---------------------------------------------- ---------------------------------------------------GEVGLSYL- --------------MKDEIQ-E-------------------------------------- ------------------------------------------------------------ -------ECPRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------DED--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_anatinus_ENSOANP00000006726 ------------------------------------------------------------ ---------------------------------------------------------RAR --L-QVTELV-LDN-C---------HSVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------SDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSLANVELTSLAR-------------------------LPSLSKLRK--L ELS-------DNII--SGGLEVLAEKCPNLTYLNL-GNKIKDLSTVEALQNLKSLKSLDL ------FNCE-ITNLEDYRESVFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDDG------R------- -C---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GWAD----------------- ---------------------------PRGEG----------------EPEAGRQTR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KQEP------------------------------- -------------ENQWLHRAG-------------------------------------- ------------------------------------------------------------ ---------SDPGE------G--------------------------------------- -------------------------------------------------EEEEVGLSYL- --------------MKEEIQ-DED----------DDDD---------------------- ---------------------YV------------------DRX-EGRK-----LS-KE- -------EGTRGEKRKRDAADE-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_domestica_ENSMODP00000019786 -------M----DI-----------KR--------------------------------- -------------------------------------------------WLTLELGNRKL --G-EVKDLL-LDN-C---------SSEDGKIGG-------------------------- ------------------------------------------------------------ ---------------L---------------------TSEFENLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMISIYLVSLVN-------------------------LPKLP------- -------------------LEVLAEQTPSPVQLNLSRNKIKD--TLEPLKKLPHLKSLDP ------FNCD-VTMLMSYRESAFGLLSQLTYLDGY------STN--EK------------ -EAP-----------------------------D--SDPE--ADR--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GLDT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TDEE-G------------------------------------ ------------------------------------------------------------ ------------EDIKEEEED--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >O_cuniculus_ENSOCUP00000003696 -------M----EM-----------KK--------------------------------- -------------------------------------------------KIN-KLRNRAL --E-DVIQLV-LDN-C---------PCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------KDTFK-LA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMPNVELSYLAQ-------------------------LPILNKLQK--L ELS-------DNII--SRGLGALEEKSPNFIYINLSGNKIKDLSTVEALQNLKNFKTLDL ------FNCE-ITNLEDYRGSIFKLLQQITYLDGF------DQE--DN------------ -KAQ-----------------------------D--SKED--DDEX------XXXXXXXX XX---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------XXXX----------------- ---------------------------XXXXX----------------XXXXXXXXX--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------XXXE------------------------------- ---------------DDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVDLSYL- --------------MKDEIQ-DE------------DDD---------------------- ---------------------YV------------------GEG-EEEG-----DE-EE- --------ECLGEKRK-DAEDD-G-V---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >C_intestinalis_ENSCINP00000018746 -------MSSAGEM-----------LK--------------------------------- -------------------------------------------------RIQLESRGRQP --E-QIEDLI-LDN-C---------RSA-GEPEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEFTSLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KLSMINTGITSLKG-------------------------FPALPALKK--L ELS-------DNRI--SGSLACL-KGCTSLTHLNLSGNKIKTIEALQPLSELPLLTLLDL ------FNCE-VTKFPRYRENVFALLPNLKYLDGF------DAN--DT------------ -EAV-----------------------------D--SDDE-------------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GSGD----------------- ---------------------------EEENGIDGNHVENG-------EEEDDEDDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DQEDGEED--------------------------- -------DDEEDGVPVNEDSRN-------------------------------------- ------------------------------------------------------------ ---------SVEDESDAGSDE--------------------------------------- -------------------------------------------------EEEEVGLAYL- --------------DGDDIE-DED----------DDGD---------------------- ---------------------YD------------------GEEEEEEEEDDDIDE-EEQ GAG----ESSRGVKRKHEEEEE-EGG---------------------------------- ------------------------------------------------------------ ------------ENE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >A_gambiae_AGAP005075-PB -------------M-----------EK--------------------------------- -------------------------------------------------RILLEKRGRPD --D-EITELI-LDN-C---------RST--YIDG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDSFTALE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TLSLINVGLVSLKN-------------------------FPKLSNLRK--L ELS-------DNRI--SNGLNHLT-GSPKLTHLNLSGNRIKDFDELQPLKDLENLEVLDL ------FNNQ-VTLIENYREKLFQLIPSLNYLDGF------DKE--YV------------ -EAP-----------------------------S--DEED--MAE--------------- -E---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------EEPE-------DSCE------ ---------------------------ESDEEE------VSL--AYLYNDNLEEDQE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DWKSVESDYNN------------------------ -------ADEEFDSEEEEDEEG-------------------------------------- ------------------------------------------------------------ ---------GGGGGGGGENEG--------------------------------------- -------------------------------------------------EDGGDSDGKG- --------------EDEEGEEEED----------GEDD---------------------- ---------------------ADGSEAAASSTAAVAAEADESKSTATEAAAATSST-TED VAKEG-EPEARGKKRKFQGTDSDG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >A_aegypti_AAEL001605-PA -------------M-----------EK--------------------------------- -------------------------------------------------RIALEKRGLPD --D-KITELI-LDN-C---------RST--SIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDSFTALE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLSLINVGLVSLKN-------------------------FPKLPALRK--L ELS-------DNRI--QNALSHLT-GSPKLTHLNLSGNRIKDFEELQPLKELENLEVLDL ------FNNE-VTMTQNYRDKIFELIPSLKYLDGF------DRE--DA------------ -EAP-----------------------------S--DEDD--EAN--------------- -G---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GTGEEDYDSDLDPSS------ ---------------------------DYDEEEDEDGNLVSL--ADVYNENLEEDGS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DWNEEDGE--------------------------- -------DDEDFDDPTDEDEDD-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GEGEGEGEGE------------------------------------ --------------------------------GEVAAENAGSDSEAGEE----------- -------SEARGKKRKLEGNDG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >D_melanogaster_FBpp0112004 -------------M-----------EK--------------------------------- -------------------------------------------------RIELERRARKV --N-QITELN-LDN-C---------RST--SIVG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDEYTALE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SLSLINVGLTTLKG-------------------------FPKLPNLKK--L ELS-------DNRI--SSGLNYLT-TSPKLQYLNLSGNKIKDLETLKPLEEFKNLVVLDL ------FNND-ATQVDNYREKIFKMLPSLNFLDGF------DCN--DE------------ -EVQ-----------------------------SDGDDDD--EVN--------------- -G---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------NDSDEVG----DKCNAFCLNG LEIDLDELEAFEKRVKAKKSLQDKPPPQSEDKE------VDELDEYLKELQLRESTD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ASTDEQSVINATPQPPSNSNLSFVILLYWFLAILN LGSATYFSDEDDDSDDSDEEAN-------------------------------------- ------------------------------------------------------------ ---------GEVSLSEVYNDD--------------------------------------- -------------------------------------------------LEEDNSDWEG- --------------EDEAGEEDE------------EED---------------------- ---------------------SD---------------IDDADGDANESAASVNAK-DKD GEKEADESQVRGKKRKHD-----G------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >G_gorilla_ENSGGOP00000000179 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINLELRNRSP --E-EXXXXX-XXX-X---------XXXXXXXXX-------------------------- ------------------------------------------------------------ ---------------X---------------------XXXXXXXX--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------XXXXXXXXXXXXXX-------------------------XXXXXXXXX--L ELS-------DNII--SGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000013309 -------V----NM-----------KR--------------------------------- -------------------------------------------------RLHLELKHQTP --P-AVLKLV-LDN-C---------QSSDGEIEG-------------------------- ------------------------------------------------------------ ---------------F---------------------TVEFLNLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLHLITVGLISFSN-------------------------L----------F WLP-------DNRD--FGDLDML-----KLTYLNLDGNTLKDIRTLEPLKKLEHPKSLDL ------LNSE-VTSLNEDWESVFKLLPQLTYLDHY------DQE--DQ------------ -EAH-----------------------------N--SDVE--G----------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------DVDD----------------- ---------------------------KEEDEEG--------------ENEENEEDK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DSEEEE----------------------------- -------FDGDEDEDESEDVDC-------------------------------------- ------------------------------------------------------------ ----------EEGDDEK--EG--------------------------------------- -------------------------------------------------D---------- --------------DESEDV-DCE----------EGDD---------------------- ---------------------ES------------------EDVDCEEGDDESEDV---- -------DCEEGDDESEDVDCE-EGD---------------------------------- ------------------------------------------------------------ ------------DE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >P_pygmaeus_ENSPPYP00000001060 -------M----EM-----------KK--------------------------------- -------------------------------------------------KINLELRNRSP --E-EVTELV-LDN-C---------LCVNGEIEG-------------------------- ------------------------------------------------------------ ---------------L---------------------NDTFKELE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FLSMANVELSSLAR-------------------------LPSLNKLRK--- -------------------------------------------------QNLKNLKSLDL ------FNCE-ITNLEDYRESIFELLQQITYLDGF------DQE--DN------------ -EAP-----------------------------D--SEEE--DDE--------------- -D---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GDED----------------- ---------------------------DEEEE----------------ENEAGPPEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------YEEEEEEE--------------------------- -------EEEDEDDDEDEDEAG-------------------------------------- ------------------------------------------------------------ ---------SELGE---------------------------------------------- -------------------------------------------------GEEEVGLSYL- --------------MKEEIQ-DEE----------DDDD---------------------- ---------------------YV------------------EEG-EEEE-----EE-EE- -------GGLRGEKRKRDAEDD-G-E---------------------------------- ------------------------------------------------------------ ------------EEDD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >C_elegans_F33H2.3 ----------MPSM-----------AE--------------------------------- -------------------------------------------------IYVKELRERDP --A-TVDTLF-LDN------------AEDGQIGG-------------------------- ------------------------------------------------------------ ---------------L---------------------TDQLINLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MLSMVKCGLTTLAG-------------------------FPTLPALTY--L DIS-------DNQLGDNASFDVLVKNAPDLKKITLASNKL-SLDNLRCLKVLPNLFELDL ------SNNPSLGLLEDYREKMFEMIPSLKILDGC------DVD--GE------------ -EVE-----------------------------E-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EF-AGEGGE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DSEEG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SG--------------------------------------- -------------------------------------------------DEDGPGLSYL- --------------EKSQFS-DDETDD-----Y-APEG---------------------- ---------------------GD------------------------------------- -------AEPRGTKRGASDNGE-EPD---------------------------------- ------------------------------------------------------------ ------------NKK--------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------AA GDDE------------------------------------------- >C_elegans_T19H12.2 -------------M-----------EE--------------------------------- -------------------------------------------------VYASELRGREP --E-TVDTLF-LDN------------TQGGVIGG-------------------------- ------------------------------------------------------------ ---------------I---------------------NEKLTKLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LLSMVKCGLTTLKG-------------------------MPVLPALNY--L DLS-------DNELGDDASFDVLIKCAPEIKKITLSGNRL-TLDNVRTLKMLPNLMELDL ------SNNSSLGLLDDYRVKMFEMIPSLKILDGC------DVD--GE------------ -EVE-----------------------------E-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EFAAGEGAE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DSDEG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DS--------------------------------------- -------------------------------------------------DEDGPGLSYL- --------------NKSQFS-DDETDD-----YVVPEA---------------------- ---------------------GD------------------------------------- -------AETRGAKRAASADCD-EPE---------------------------------- ------------------------------------------------------------ ------------AKK--------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------SA ---E------------------------------------------- >A_aegypti_AAEL012656-PD -------M------------------V--------------------------------- -------------------------------------------------KLTPDLINQSM QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------- ------------------------------------------------------------ ---------------M---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TIDFSDNDIRKLDG-------------------------FPHLPRLKC--L LLN-------NNRI--VRVSDTLHESLPNLESVVLTGNNVQELGDLEPLTKLPKLQSLSL ------LTNP-VSTKQYYREYVAFRFPNLRLLDFR------KIK--LK------------ -ERE-----------------------------A--AKELFKSK---------------- -K---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GKEL----------------- ------------------------------------------------QREIMRKAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LAMPAA----------------------------- ------------DKPTVHN----------------------------------------- ------------------------------------------------------------ -----------------ATPA--------------------------------------- -------------------------------------------------DIQK------- --------------IKEAIK---------------------------------------- -----------------------------------------RATNLHEVERLTRML-QS- -------GQITGE---------FNFN---------------------------------- ------------------------------------------------------------ ------------GKLQPFVRLNLVS----------------------------------- ------------------------------------------------------------ ----------------------------------------VSFQTSEWIGLRQKVPTKRL ISYSL------------------------------------------ >A_gambiae_AGAP007670-PB -------M------------------V--------------------------------- -------------------------------------------------KLTPDLINQSM QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------- ------------------------------------------------------------ ---------------M---------------------GATLDQYD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TIDFSDNDIRKLDG-------------------------FPRLARLKC--L LLN-------NNRI--VRIGENLHESLPNLQSIILTGNNIQELGDLEPLTKLPNLETLSL ------LTNP-VSTKQHYREYVAFRFPNLRLLDFR------KIR--QK------------ -ERE-----------------------------A--ANLLFKSK---------------- -K---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GKEM----------------- ------------------------------------------------HKEIVRKAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------QALPAG----------------------------- ------------ALGESSPEK--------------------------------------- ------------------------------------------------------------ ------------QAVQNASPA--------------------------------------- -------------------------------------------------DIQK------- --------------IKEAIK---------------------------------------- -----------------------------------------RATNLHEVERLNRML-QS- -------GQITGD---------I-LN---------------------------------- ------------------------------------------------------------ ------------GNESH-------S----------------------------------- ------------------------------------------------------------ ----------------------------------------INY----------------- ----------------------------------------------- >A_aegypti_AAEL006840-PA -------M------------------V--------------------------------- -------------------------------------------------KLTPDLINQSM QYMNPCRDRE-LDL-R---------GYKIPQIEN-------------------------- ------------------------------------------------------------ ---------------M---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TIDFSDNDIRKLDG-------------------------FPHLPRLKC--L LLN-------NNRI--VRVSDTLHESLPNLESVVLTGNNVQELGDLEPLTKLPKLQSLSL ------LTNP-VSTKQYYREYVAFRFPNLRLLDFR------KIK--LK------------ -ERE-----------------------------A--AKELFKSK---------------- -K---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GKEL----------------- ------------------------------------------------QREIMRKAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LAMPAA----------------------------- ------------DKPTVHN----------------------------------------- ------------------------------------------------------------ -----------------ATSA--------------------------------------- -------------------------------------------------DIQK------- --------------IKEAIK---------------------------------------- -----------------------------------------RATNLHEVERLTRML-QS- -------GQITGE---------FNFN---------------------------------- ------------------------------------------------------------ ------------GKLQPFVRLNLVS----------------------------------- ------------------------------------------------------------ ----------------------------------------VSFQTSEWIGLRQK------ ----------------------------------------------- >D_melanogaster_FBpp0088015 -------M------------------V--------------------------------- -------------------------------------------------KLTPELINQSM QYINPCRERE-LDL-R---------GYKIPQIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TIDLSDNDLRKLDN-------------------------LPHLPRLKC--L LLN-------NNRI--LRISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKLETICL ------LINP-VSTKPNYREYMAYKFPQLRLLDFR------KIK--QK------------ -DRQ-----------------------------A--AQEFFRTK---------------- -Q---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GKDV----------------- ------------------------------------------------LKEISRKSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MSAAAA----------------------------- ------------IAAEAGNGKG-------------------------------------- ------------------------------------------------------------ ---------RGSEGGRLANPQ--------------------------------------- -------------------------------------------------DMQR------- --------------IREAIK---------------------------------------- -----------------------------------------RASSLAEVERLSQIL-QS- -------GQLPDK---------F-QH---------------------------------- ------------------------------------------------------------ ------------EMEAV-------A----------------------------------- ------------------------------------------------------------ ----------------------------------------QNGAGHNGSGAVAMEY---- ----------------------------------------------- >T_nigroviridis_ENSTNIP00000009472 -------M------------------V--------------------------------- -------------------------------------------------KLSAELIEQAA QYTQ-VRDRE-LDLAR---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TIDFSDNEVRKLDG-------------------------FPLLRRLKT--L LMN-------SNRI--CRIGENLEQSLPNLRELVLTSNNIQELGDLDPLATVKTLSLLSL ------LRNP-VTNKKHYRLYVINKLPQLHVLDFQ------KVK--LK------------ -ERL-----------------------------E--AEKMFRGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIAKRTK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFTIGA----------------------------- ------------ATPLEKKKTG-------------------------------------- ------------------------------------------------------------ -----------------PSQA--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASSLAEVERLKGML-QA- -------GQIPGRDLRPDGNEMVEEE---------------------------------- ------------------------------------------------------------ ------------EEEEA-------P----------------------------------- ------------------------------------------------------------ ----------------------------------------VDGA---------------- ----------------------------------------------- >T_rubripes_ENSTRUP00000000150 -------M------------------V--------------------------------- -------------------------------------------------KLSAELIEQAA QYTNPVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TLDFSDNEVRKLDG-------------------------FPLLRRLKT--L LMN-------SNRI--CRIGENLEQALPNLRELILTSNNIQELGDLDPLATIKTLSLLSL ------LRNP-VTNKKHYRLYVINKLPQLRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIAKRTK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFTIGA----------------------------- ------------AAPLEKKKTG-------------------------------------- ------------------------------------------------------------ -----------------PSQA--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASSLAEVERLKGML-QA- -------GQIPGRDLRAGEADMVVEE---------------------------------- ------------------------------------------------------------ ------------EEEEE-------G----------------------------------- ------------------------------------------------------------ ----------------------------------------AHMAGDLGEGMSERGGNVDE DIEDAVLVARNQEAMEASRRRMQEELDAKAVVFREKQKEKEEERRKE >G_gallus_ENSGALP00000011598 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LMN-------NNRI--CRIGEGLEQALPSLTELVLTNNNISELGELDPLSSIKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKAG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKTAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QA- -------GQIPGRERKPGSAEDAEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------PTGS---------------- ----------------------------------------------- >A_carolinensis_ENSACAP00000003100 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SIDFSDNEIRKLDG-------------------------FPLLKRLKT--L LMN-------NNRL--SRIGEGLEQSLPNLKELILTNNNIMELGDLDPLATIKSLTYLSL ------LRNP-VTNKKHYRLYVIYKAPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKTG-------------------------------------- ------------------------------------------------------------ -----------------PTPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NATTLAEVERLKGLL-QA- -------GQIPGRDRKAGPSDEAEEE---------------------------------- ------------------------------------------------------------ ------------MEEDS-------I----------------------------------- ------------------------------------------------------------ ----------------------------------------ANGS---------------- ----------------------------------------------- >C_elegans_F43G6.3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MPVLPALNY--L DLS-------DNELGDDASFDVLISSAPKLKRLTLSGNPL-SLEKVRTLRMLPYLQELDL ------TNIQALGAFDDYRSVVFEMIPSLIILNGV------TIV--GE------------ -DV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PNYSRI- --------------PKSIRE-DAEKERQWIILWQLLSS---------------------- ---------------------PK------------------------------------- -------SETR-------------PR---------------------------------- ------------------------------------------------------------ ------------HKKYLLATSLLLS----------------------------------- ------------------------------------------------------------ ----------------------------------------SRIFDQLWRNFALDRCLTSR GTLY------------------------------------------- >T_guttata_ENSTGUP00000009232 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LMN-------NNRI--CRIGENLEQALPSLTELILTNNNIAELGELDPLSSIKSLTYLSV ------LRNP-VTNKKHYRLYLIHKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKTG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKAAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QA- -------GQIPGRERKPGPSEDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------PNGS---------------- ----------------------------------------------- >C_intestinalis_ENSCINP00000011422 VLTQKLISRGLSNIGTSACGTMHVFLKLNLQGIGLEDISALKSLQHIQELDLSHNNLTDL SALRNMRYLVKLNVSHNELTEVLDFEPPFGLREANFSHNNITKMPGLSTHGHLSILNLEH --N-RIEEVEGLSN-CSYLQKLVLSRNLIQNISG-------------------------- ------------------------------------------------------------ ---------------F-----------------------ENLNLR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLELAHNKLTQIEN-------------------------LETVQQLQE--L DLS-------GNNLFSLCGLEGMN----DLCLLNCEGNQLSDLAEIQYIESIQSIRTLNF ------VNNP-MVEAEEYRKSVIFAMQQITELDGV------PVS--VE------------ -EKVMA-----------------------VNLFDPPPEVQAALDHITHTVYRFLQPSKIY ESTLPSIEMPYPMLVLTGPQASGKRELAHRLAQEFPDYFGFGVSHTTRVMHPGETNGKEY HFVTPNHFQALLSQGYFVQTYRHSGCLY-------------------------------- ---------------------------------------GLSLDAIESVAKEGLACVVHM EINGVRTLKNTYFEPRYVLILPVSKN-EHKARMIERGLYTKDQVKHISEKQTAMYAE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------INQENPGFFDMVINSDKLGEAYDRLRQLVMDYLGT TDLSGADAEVAVPRLSTTEHKE-------------------------------------- ------------------------------------------------------------ ----------ESGTHQTTLSGHMRRTWSRPSFHG-------------------------- -------------------------------------------------DSTNSNDPNS- --------------AKNQIKLDSRKTPVEEASYRRRQNAAKEAVEGFSPSVYDELFRRPM VPMTAPGMLEGSPMAQAASLYQDPAFAASMYPNMSQVTIENGQNYISDKTKSDRISPDSS NSSNEDSTGLSGLSSARGFSDEESYSSRTATPLAPRIVDGL------------------- ------------------------------------------------------------ ------------EDWMESFDQPDKP----------------------------------- ------------------------------------------------------------ ----------------------------------------GANIKPVLPPIPTGGR---- ----------------------------------------------- >P_pygmaeus_ENSPPYP00000021193 -------M------------------G--------------------------------- -------------------------------------------------WITEDLIRRNA EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------- ------------------------------------------------------------ ---------------LEHI------------------DKWCRDLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLQHNIHLKELFL ------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ -ERI-----------------------------K--ALQDYSVIE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KNEDKRSNAGFDGRWYTDINATL------------ ------------------------------------------------------------ ------------------IDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI KGKPFQLVLPAEVKPDSSSAK--------------------------------------- -------------------------------------------------RSQTTGHLVIC MPKVGEVITGGQRAFKSMKTTSDR----------SREQ---------------------- ---------------------TN------------------TRSKHMEKLEVDPSK-HSF PDVTNIVQEKKYTPRR-RPEPKIIPS---------------------------------- ------------------------------------------------------------ ------------EEDPTFEDNPEVP----------------------------------- ------------------------------------------------------------ ----------------------------------------PLI----------------- ----------------------------------------------- >T_rubripes_ENSTRUP00000025664 VFFSGFAHMVGLSFFPNLRHLTIVGQE--------------------------------- -------------------------------------------------LTKIEALEGCP ----LLEELW-VAE-C---------RLT--EISG-------------------------- ------------------------------------------------------------ ---------------LDKCLQLKKLYLYDNQISEINNVEFLINLD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VLWLNSNSISRIQG-------------------------LNRLQNLLE--L NLA-------DNKI--EKIGQSL-DPNTNLQNLNLSGNKISSIKDLTKLAHLPQLRELML NDPT-TTPNP-VCLLHNYATHVLYHMPQLQHLDTH------DIS--ST------------ -EVK-----------------------------D--TAESIVMKKMMYYNMRVQTAQRKL RETRLSLLERKKIMLEPPEESLTRINHCLKSLEHELSKVSSACEMKDGTVEDSVQSRDPT HPSPDPSIKQKIISKMEALKKRQAYWTRRLVEIDAWFKKNLAQAAHMTDYTVQFLLMELE SVGNIRLEEGCPADRWFTSCCDLLLSRFRQLDFEVHSISGIKVNRVIRISNSALRLRFED KFDSLRTSNDGSVQYNRCQLEHLFYLSDPEKDEKREILGIIEEGFQRVEEREASQGEGFI PFSNSLFLTEQPRIAHALTQACKADSECNIDPIPFRHSQVIVSKVFVGQSVPLVVGSPLD QNHYPNAYSVYQNVENRFRTGGREEGTCSSPTHSVPECSLGQRRWFVFDPELVLPEYIIF FEYVFEVRCKTELPDLSRHREGAPSGSSVLDGEVLNMEPVLKPQPKLLSLDNNLLLNVAR ANFLSQITMLNLHGHSLNKIKAVSSLTALRHLNISFNAFTRLDDISHMPNLEFLDASYNH LITLEGLRDLERLKHLDVSWNKLTKSREEAAVLRKHTPTLLKLDTRHNPWKKPKSVRLTL LGYLKTLTHLDGVTVAEEEAAEAVQMVAGSKINQASLLSHSRTNSERPHRLSLLPTAQLL CLLNPPPWGLTQDLGPDWAAKITTLDFNSQGIYKLTNLSGLVNLRWASFNDNDLSKVEGL ECCVNLEELSLNNNNISTLSGLSKLQRLKKLSLNGNQLTSLDSSVLDQLPQLCFLSVEDN SIASLHGIRRARSLLEFYICNNCISMSKDIYCLKELANLIILDLSGNPVEKVENYRNYVL FHLPELKALDGAAVEAPECESAKEMFGGRLIPDVLTERLGLTNCADITSLTLQSFSIRVV DLNPPELFSSLHTVRLDHNNLTSFSGLVHLPHIRDLSLNYNHIESVLPKQKIPNLT-NKQ ILYNKVHSSGYGKQRSLKGKGEPGQSCGLEPLMDSLEVLHLSHNGISNMANLELSRLTSL KALFLEGNEIRHVDGLEGLHQLRELVLDKNRIKTLAEDSFISQNSLLELHLSENRIQDLG HLGQLSKLRKLFLDSNRVQDITELE----------------------------------- ------------------------------------------------------------ ----------------------------------------KLQFLTSLSELSLIDNPVDS SSLYRPSVLLRLPLLKVLDGERVTLEDRARVELLNVEETVRTALN-- >M_mulatta_ENSMMUP00000020530 -------M------------------G--------------------------------- -------------------------------------------------WITEDLIRRNA EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------- ------------------------------------------------------------ ---------------LEHI------------------DKWCRDLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLKHNIHLKELFL ------MGNP-CAFFDHYREFVVATLPQLKWLDGK------EIE--PS------------ -ERI-----------------------------K--ALQEYSIIE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA PDTEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKNQEKLSERKKKVKP PRTLITEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLINVDVQPTYVRVMI KGKPFQLVLPAEVKPDSSSAK--------------------------------------- -------------------------------------------------RSQTTGHLVIC MPKVGEVITGGQRAFTSVKTTLDR----------SREH---------------------- ---------------------IN------------------TRSKHMEKLEVDPSK-HSF PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------- ------------------------------------------------------------ ------------EEDPTFEDNPEVP----------------------------------- ------------------------------------------------------------ ----------------------------------------PLI----------------- ----------------------------------------------- >B_taurus_ENSBTAP00000018076 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRAGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------ANGS---------------- ----------------------------------------------- >E_caballus_ENSECAP00000017313 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QA- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >O_anatinus_ENSOANP00000018632 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRVGEGLDQALPSLRELILTNNSILELGDLDPLATLKSLTYLSI ------LRNP-VTNKKHYRLYVIHKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRTK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERKSGPADDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDP-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >M_domestica_ENSMODP00000015061 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLKRLKT--L LVN-------NNRI--CRIGEGLDQALPSLRELILTNNSIVELGDLDPLATLKSLTYLSI ------LRNP-VTNKKHYRLYVIHKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRTK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERKSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------ANGS---------------- ----------------------------------------------- >G_aculeatus_ENSGACP00000013527 -------------MESKRDKDQEADCE--------------------------------- -------------------------------------------------KITAVLLKSRT GEF-DLESILFLKL-----------RGLGIHDLG-------------------------- ------------------------------------------------------------ ---------------C---------------------LGECMSLE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KLDLSANNITNLAP-------------------------LASLRLLSV--L GLS-------ANRI---SNLDPL-RSCDSLQHLNLAGNIISSIESLHCLQPLRKLENIRL KDNTYNYSNP-VCRNSAYRNTVLEMFPNIKVLDGE------RVVGRGS------------ -DLY-----------------------------QLCKDIDDTIKA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GLYK----------------- ------------------------------------------------NGQLVEHSD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CKPWVEDNYW-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EIKRSNNAI-- --------------IEEAYK---------------------------------------- -----------------------------------------QFNDVLHECRLLNNRATHV ISQTERSMSLKKQPKQYAI----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >M_musculus_ENSMUSP00000032723 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSAG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPSDEGEEE---------------------------------- ------------------------------------------------------------ ------------IEDDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >R_norvegicus_ENSRNOP00000016758 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSAG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPSDEGEEE---------------------------------- ------------------------------------------------------------ ------------MEDGT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >C_familiaris_ENSCAFP00000015542 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >H_sapiens_ENSP00000254193 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >M_mulatta_ENSMMUP00000015518 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >P_pygmaeus_ENSPPYP00000007744 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >P_troglodytes_ENSPTRP00000041754 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAA QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--L LVN-------NNRI--CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KVK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GAQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRERRSGPTDDGEEE---------------------------------- ------------------------------------------------------------ ------------MEEDT-------V----------------------------------- ------------------------------------------------------------ ----------------------------------------TNGS---------------- ----------------------------------------------- >H_sapiens_ENSP00000250173 -------M------------------G--------------------------------- -------------------------------------------------WITEDLIRRNA EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------- ------------------------------------------------------------ ---------------LEHI------------------DKWCRDLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL ------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ -ERI-----------------------------K--ALQDYSVIE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA PDTEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKP PRTLITEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI KGKPFQLVLPAEVKPDSSSAK--------------------------------------- -------------------------------------------------RSQTTGHLVIC MPKVGEVITGGQRAFKSMKTTSDR----------SREQ---------------------- ---------------------TN------------------TRSKHMEKLEVDPSK-HSF PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------- ------------------------------------------------------------ ------------EEDPTFEDNPEVP----------------------------------- ------------------------------------------------------------ ----------------------------------------PLI----------------- ----------------------------------------------- >P_troglodytes_ENSPTRP00000035210 -------M------------------G--------------------------------- -------------------------------------------------WITEDLIRRNA EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------- ------------------------------------------------------------ ---------------LEHI------------------DKWCRDLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L NLA-------LNNI---EKIENL-EGCEELAKLDLTVNFIGELSSIKTLQHNIHLKELFL ------MGNP-CASFDHYREFVVATLPQLKWLDGK------EIE--PS------------ -ERI-----------------------------K--ALQDYSVIE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PQIREQEKDHCLKRAKLKEEAQRKHQEE-D--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KNEDKRSNAGFDGRWYTDINATL-SSLESKDHLQA PDIEEH--NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKNQEKLSEKKKKVKP PRTLIAEDGKALNVNEPKIDFSLKDNE--KQIILDLAVYRYMDTSLIDVDVQPTYVRVMI KGKPFQLVLPAEVKPDSSSAK--------------------------------------- -------------------------------------------------RSQTTGHLVIC MPKVGEVITGGRRAFKSMKTTSDR----------SREQ---------------------- ---------------------TN------------------TRSKHMEKLEVDPSK-HSF PDVTNIVQEKKHTPRR-RPEPKIIPS---------------------------------- ------------------------------------------------------------ ------------EEDPTFEDNPEVP----------------------------------- ------------------------------------------------------------ ----------------------------------------PLI----------------- ----------------------------------------------- >R_norvegicus_ENSRNOP00000037753 -------MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRPQNPP----- -------------------------------------------------SMWTKVSSQQP IKL-AIRDLP-NDEITVTDKDP---PEASSEVEGEMLAPQDTVIIGEAAPSIAMEDTPNP PITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGRQRVKSYTPKPRGGR KSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRMLEPRSERTAGKTSLKRM VPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTPLRAVLQPTPATSEEQVTA SIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDREKRPSTAHGTLVTPQVKAVL TTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPSALPPGWPNLHPKAEYPPDLFSV EDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAP ELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYIL DLSMLIVFFLDSLI--AWWESLLLLLAYALYVFTMKWNKQIERWVKEQLSRRPVAKVMAL ------------GDLSKVRHEVLEHRGGAQGEEGTRDDYIERKK--DE------------ -EGETE-----------------------AERKEHGQEEETETKGKEKQEGETESEGKDE QE---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GETE----------------- --------------------------AEGKEADHEGETEAEGKEVEHEGETEAEGTE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEA ERKETNHEGETEAEGKEADHEG-------------------------------------- ------------------------------------------------------------ ---------ETEAEGNVEHQG--------------------------------------- -------------------------------------------------ETEAEGKVEHE GETEAG--------EKDEHEGQSETQADDTEVKDGEGE---------------------- -----------------------------------------AEANAEDQCETAQGEKGAD GGGGSDGGDSEEEEDEEDEEEEEEEE---------------------------------- ------------------------------------------------------------ ------------EEEEEEESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQVR AVKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVI VARKGLGDMAVSSSVGRDGVEWGWSLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLML LFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV >E_caballus_ENSECAP00000002990 -------M------------------G--------------------------------- -------------------------------------------------RITEDLIRRNA EHN-DCVIFS-LEE-L---------SLHQQEIER-------------------------- ------------------------------------------------------------ ---------------LEHI------------------DKWCRDLK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ILYLQNNLIGKIEN-------------------------VSKLKKLEY--L NLA-------LNNI---EKVENL-EGCEGLTKLDLTINFIGELSSIKTLRHNIHLKELFL ------MGNP-CADFDGYRQFVVATLQQLKWLDGK------EIE--RS------------ -ERI-----------------------------Q--ALQNFPVIE--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QQIREQEKAYCLKRAKDKEEAQRKLQEDAD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EGKKERSQPGFDGRWYTDIGAPLPSSVESKD-LQA PEIQEGECNRKKVEDEEDDLEFWNKPSLFTPESRLETLRHMEKQRKAQEKLSDKKKKVKP ARTLITEDGKALNVNEPKLDFSLKDDEKRKQIVLDLAVYRYLDTSLIDVDVRPTYVRVLV KGKPFQLVLPAEVKPDSSSAK--------------------------------------- -------------------------------------------------RSQTTGHLVIC MPKVDEVITGCPPASKPVASTLDS----------SRER---------------------- ---------------------KT------------------ERSRHTEKLEVDPSK-RSF PDVANIVQEKKHTPRRVRSEPKITPT---------------------------------- ------------------------------------------------------------ ------------EEDPDFEDNPEVP----------------------------------- ------------------------------------------------------------ ----------------------------------------PLI----------------- ----------------------------------------------- >G_gorilla_ENSGGOP00000008764 -------M------------------V--------------------------------- -------------------------------------------------KLTAELIEQAX QYTNAVRDRE-LDL-R---------GYKIPVIEN-------------------------- ------------------------------------------------------------ ---------------L---------------------GATLDQFD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AIDFSDNEIRKLDG-------------------------FPLLRRLKT--X LVN-------NNRI--CRIGEGLDQALPCLTELILTNNRLVELGDLDPLASLKSLTYLSI ------LRNP-VTNKKHYRLYVIYKVPQVRVLDFQ------KMK--LK------------ -ERQ-----------------------------E--AEKMFKGK---------------- -R---------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GSQL----------------- ------------------------------------------------AKDIARRSK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TFNPGA----------------------------- ------------GLPTDKKKGG-------------------------------------- ------------------------------------------------------------ -----------------PSPG--------------------------------------- -------------------------------------------------DVEA------- --------------IKNAIA---------------------------------------- -----------------------------------------NASTLAEVERLKGLL-QS- -------GQIPGRECRS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------