>H_sapiens_ENSP00000385749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPPACPSEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQLHGIQQVLKDC--------------IVHLCISKPERPMKFLR EHFEKLEK----EENRQILAR--------------------------------------- ----------------------QKSN-SQSDSHDEEVSP-TPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--NEGDNFY--VV-DQ--GEVDVYV-NG--E----WVTNISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGEPGDDFYIITEGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000026973 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPSCFHSEDEDSLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEMYVQKHGIQQVLKEC--------------IVHLCVAKPDRPLRFLR EHFEKLEK----EENRQILAR--------------------------------------- ----------------------QKSN-SQCDSHDEEISP-TPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFSHL-DDNE-RSDIFDAMF PVTHI----GGETVIQQG--NEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTNISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGEPGDDFYIITEGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000016544 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMASQSSYQVEEDESLKE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHGVQQVLKDC--------------IVHLCISKPDRPMTFLR EHFEKLEK----EENRQIQSQ--------------------------------------- ----------------------QK-----SDSHDEEVSP-TPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGTASVLQRRSP------NEEYMEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000000612 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMATSSSCNLEDDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQQILKEC--------------IVNLCIAKPDRPMKFLR EHFEKLEK----EECKQILAC--------------------------------------- ----------------------QKSN-SQSDSHDDEISP-PPPN---------------- ----------PAVKAR-HRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGEIVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEKFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGQPGDDFFIITEGTASVLQRRSD------KEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000010661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASSSSYNLEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQQLLKEC--------------IVNLCISKPDRPMKFLR EHFEKLEK----EECKQILAR--------------------------------------- ----------------------QKLS-SQSDSHDDEISP-PPPN---------------- ----------PVVKAR-CRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVILQG--DEGDNFY--VI-DQ--GEVDVYV-NM--E----WVTNIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALETAQFED GEKIVVQGQPGDDFFIITEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000005814 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAAASSCSVEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQQILKEC--------------IVNLCIAKPDRPMKFLR EHFEKLEK----EECKQILAR--------------------------------------- ----------------------QKSS-SQSDSHDDEISP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000008775 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAAAASCNVEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQQILKEC--------------IVNLCIAKPDRPMKFLR EHFEKLEK----EECKQILAR--------------------------------------- ----------------------QKSS-SQSDSHDDEISP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000015074 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MATSSSTLEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEIFVQKHNIQQILKEC--------------IVNLCIAKPERPMKFLR EHFEKLEK----EECKQIMAR--------------------------------------- ----------------------QKSN-SQSDSHDDEVSP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000010584 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KMATSSSTLEEDESLKS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEIFVQKHNIQQILKEC--------------IVNLCIAKPERPMKFLR EHFEKLEK----EECKHIMAR--------------------------------------- ----------------------QKSN-SQSDSHDDEVSP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----LVTNIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000007339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MATSSSTIDEDDSLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEIFVRKHNIQQILKEC--------------IVNLCITKPERPMKFLR EHFEKLEK----EECKQIMAR--------------------------------------- ----------------------QKSN-SQSDSHDDEVSP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALARAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----LVTNIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSILAESLDKWERLTVADALEPVQFED GEKIVVQGAPGNDFFIITEGIASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRIRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gorilla_ENSGGOP00000011641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASPPACPSEEDESLKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQLHGIQQVLKDC--------------IVHLCISKPERPMKFLR EHFEKLEK----EENRQILAR--------------------------------------- ----------------------QKSN-SQSDSHDEEVSP-TPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RXXXXXXXX XXXXX----XXXXXXXXX--NEGDNFY--VI-DQ--GEVDVYV-XG--E----WVTNISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-XX XXXXXXXXXXXXXX--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGEPGDDFYIITEGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000031475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MAGPARRPARRRRGTGCAAGSAHPGHPPALGRRTAA ADPPRPPPPPGPG----SRRSLPAPGPLPRRGPRGGVAHLSSETPHVGPPGRGGGWGRKG REKRQRRRGRRGGEGPRREAENSAEVDYRFMGLSDLPKCLRTMASGSTATSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAS-SRADSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000033202 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MSPQIM--C--------------VSVCGEGMGWDPVEISQ SHAEGCAQTTGLEENRQILAR--------------------------------------- ----------------------QKSN-SQCDSHDEEISP-TPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFSHL-DDNE-RSDIFDAMF PVTHI----DGETVIQQG--NEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTNISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGEPGDDFYIITEGTASVLQRRSP------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000011371 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMASGTT-ASEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFEKLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-SRADSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000013014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TMAASGSSSSEEDRSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKDC--------------IVQLCTVRPERPMVFLR EHFEKLEK----EETKQFLTQ--------------------------------------- ----------------------QK---SRTDSREDEISPPPPMN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF PVTYI----AGETVIQQGK--EGNNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGTAAVLQRRSE------HEEFVEVGRLAPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000020932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MTGPSPEPRVLRGSTQDARSVHQ--EHLSIRLRSAV VDPLGPPPLPTAGISLSAQRPVTPSPSLPSHSTQGGVAHLSPNRPTWVCGRR-----VEG REKRQRRGGRQTQEPPRNRGE--AEISEQLNNLEDPPPHLRTMASGSMATSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTTRPERPMAFLR EYFERLEK----EEARQIQCL--------------------------------------- ----------------------QKTG-IRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGTAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000024266 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASGSVSSEEEKSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEVYVQKHNVQQLLKDC--------------IVQLCTSRPDRPMAFLR EYFERLEK----EESKQLLNQ--------------------------------------- ----------------------QKAS-SRSDSREDEVS--PPMN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVTYI----AGEIVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED SQKIVVQGEPGDEFFIILEGCAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000000501 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGST---EEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRADSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_cuniculus_ENSOCUP00000014966 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MASGSTAASEEERSLQE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIRALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKQDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000042610 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VMASGSTSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKDC--------------IVQLCTSRPDRPMAFLR EYFERLEK----EEVKQIQNQ--------------------------------------- ----------------------QKASNSRSDSRDEEVS--PPMN---------------- ----------PVVKGR-RRR-GA--FSAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVTYI----AGETVILQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WVTSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLRK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000002929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAT----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF SVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GETDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000351410 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF SVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GETDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000006731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MATSSSSSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQQLLKDC--------------IVQLCTVRPDRPMGFLR EYFERLEK----EETKQLLNQ--------------------------------------- ----------------------QKSG-SRSDSREDEISPPPPMN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF PVTYI----AGETVIQQGKCDEGDNFY--VV-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILMASGSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGTAAVLQRRSE------NEEFVEVGRLAPSDYF-G-EIALL M--NRPRAATVVA--RGL-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000012860 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASGSTSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKDC--------------IVQLCTSRPDRPMAFLR EYFERLEK----EEAKQIQNQ--------------------------------------- ----------------------QKAGSSRSDSRDEEVS--PPMN---------------- ----------PVVKGR-RRR-GA--FSAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PVTYI----AGETVILQG--DEGDNFY--VI-DQ--GEMDVYV-NN--D----WVTSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLRK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-GSEIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000004221 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MAASSSSSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYIQKHNIQQLLKDC--------------IVQLCTVRPERPMGFIR EYFERLEK----EETKQLLNQ--------------------------------------- ----------------------LKSG-SRSDSREDEISPPPPLN---------------- ----------PVVKYR-SRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFTHL-DDNE-RSDIFDAMF PVTYI----AGETVIQQGKSDEGDNFY--VV-DQ--GEMDVYV-NS--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GNTLRKRNMYEKFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGTAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000015837 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASGSTSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKDC--------------IVQLCTSRPDRPMAFLR EYFERLEK----EEAKQIQNQ--------------------------------------- ----------------------QKASNSRSDSRDEEVS--PPMN---------------- ----------PVVKGR-RRR-GA---SAEVYTEE---DAA----TYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF PVTYI----AGETVILQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WVTSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLRK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYFAG-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000045750 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF SVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GETDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFI---GSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000021027 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASSSTSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CERYVQKHNIQQLLKDC--------------IVQLCTARPERPMAYLR DYFEKLEL----EEAKQMVSQ--------------------------------------- ----------------------QKSS-SRSDSREDEVS--PPMN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAT----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF SVTYI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WVTSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALETVQFED GQKIVVQGQPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLAPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_pygmaeus_ENSPPYP00000010056 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MESGSTAASEEARSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTARPERPMAFLR EYFERLEK----EEAKQIQNL--------------------------------------- ----------------------QKAG-TRTDSREDEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF SVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GETDVRF-TN-------IKNIVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000006172 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASSSTSSEEERSLQE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKEC--------------IIQLCTARPDRPMNFLR DHFERLQK----EEAQQIAAQ--------------------------------------- ----------------------QRSG-SRSDSREEEVS--PPMN---------------- ----------PVVRGR-TRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAMEKNVLFAHL-DDNE-RSDIFDAMF SVNYI----AGETVIQQG--DEGDNFY--VI-DV--GEMDVYV-NN--E----LVTSIGE GGSFGELALIYGTPRAATV--R-------------------------------AKSN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEIVPFVD RQKIVVQGEPGDEFFIILEGTAAVLQRRSE------DEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--CGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------EQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000011151 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KCLLITT--------------LTQILNPAPKNPVKAGR KYFEGLQ-----EECKQILAR--------------------------------------- ----------------------QKSN-SQSDSHDDEISP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALAKAISKNVLFAHL-DDNE-RSWIFFSLV PHFWVNFALAYILCLVLG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000012829 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASGSSSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEHYVQKHNIQALLKDC--------------IVQLCTSRPERPMAFLR EIFEKLEK----EEAKQLQNL--------------------------------------- ----------------------QKAS-SRSDSREDEISPPPPMN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF PVTYI----AGETVIQQG--DEGDNFY--VV-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFER----PGSLLGHPQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AKHP--------------------------------------- AVQQLRLA---------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------VRLKRRSPA RSRLHQ------------------------------------------------------ --------------------RRLLSLLHS >O_latipes_ENSORLP00000004817 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MASGSTSSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEQYVQKHNIQQLLKDC--------------IVQLCTSRPDRPMAFLR EYFERLEK----EEAKQIQNQ--------------------------------------- ----------------------QKAGSSRSDSRDEEVS--PPMN---------------- ----------PVVKGR-RRR-GA--FSAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF PVTYI----AGETVILQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLRK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------HEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFE---GP-GPLLGHTQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQHP--------------------------------------- TVQQLCVA---------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------VRLRERLSS PSLLPS------------------------------------------------------ --------------------PLTLRPLRP >T_nigroviridis_ENSTNIP00000021133 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------Q----EECKQIMAR--------------------------------------- ----------------------QKSN-SQSDSHDDEVSP-PPPN---------------- ----------PVVKAR-RRR-GG--VSAEVYTEE---DAV----SYVR------------ -------------------KVIPKDYKTMTALARAISKNVLFAHL-DDNE-RSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----LVTNIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGAPGNDFFIITEGIASVLQRRSD------NEEYVEVGRLGPSDYFAG-EIALL L--NRPRAATVVA--RGP-LKCVKLDRIRFERVLGLCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000005486 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------IMATSGASSEEERSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTVRPDRPMAFLR EYFERLEK----EESKQLQALALPV----------------------------------- ----------------------QKAV-ILAETREEEISP-PPPN---------------- ----------PVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF PASFI----AGETVIQQG--DEGDNFY--VI-DQ--GEMDVYV-NN--E----WATSVGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFER----PRPLLRHPQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQHP--------------------------------------- AVQQLCVT---------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------ICLKFGSLA ------------------------------------------------------------ ----------------------------- >D_melanogaster_FBpp0099624 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSYMMAKTLEEQSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEHYIQTHGIQRVLKDC--------------IVQLCVCRPENPVQFLR QYFQKLER----EQVKLDASR--------------------------------------- ----------------------QVIS----PDDCEDLS--PMPQ---------------- ----------TAAPPV-RRR-GG--ISAEPVTEE---DAT----NYVK------------ -------------------KVVPKDYKTMNALSKAIAKNVLFAHL-DESE-RSDIFDAMF PVNHI----AGENIIQQG--DEGDNFY--VI-DV--GEVDVFV-NS--E----LVTTISE GGSFGELALIYGTPRAATV--R-------------------------------AKTD-VK LWGIDRDSYRRILM--GSTIRKRKMYEEFLSR-VSIL-ESLDKWERLTVADSLETCSFDD GETIVKQGAAGDDFYIILEGCAVVLQQRSE------GEDPAEVGRLGSSDYF-G-EIALL L--DRPRAATVVA--RGP-LKCVKLDRARFERVLGPCADILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_gambiae_AGAP006448-PB ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------MSNAQEEEQHLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CESYIQTHCIQRLLKDC--------------IVQLCVSRPENPIVFLR QYFQKLER----EQAKLDASK--------------------------------------- ----------------------QAVT----PDDLDDLS--PMPQ---------------- ----------TAVPPV-RRR-GG--ISAEPVTEE---DAT----SYVK------------ -------------------KVVPKDYKTMAALSKAIAKNVLFSHL-DENE-RSDIFDAMF PCNFL----PGEPIIQQG--DEGDNFY--VI-DI--GEVEVFV-NN--E----QVTTISE GGSFGELALIYGTPRAATV--R-------------------------------AKTD-VK LWGIDRDSYRRILM--GSTIRKRKMYEEFLSR-VSIL-ESLDKWERLTVADALEPVSFED GETIVRQGEPGNDFYIIVEGCATVMQKRGD------SEEAAEVGRLGPSDYF-G-EIALL L--DRPRAATVIA--RGP-LKCVKLDRARFERVLGLCADILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_intestinalis_ENSCINP00000005337 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ICDITMAGEEEQGLKE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CEAYVHEHKIQQTLKDC--------------IVQLCIHKPEKPMKFLR EHFEALEK----EEAAPPSPS--------------------------------------- ----------------------STNEKSNQESGEEEPAVTPPTK---------------- ------------LFQT-QRR-GA--VSAEVYTDD---DQS----PKSNSHLNNVKLIFPP IKLSFYKQPQQLCPKPQSFQVITKDYKTMASLSKAIEKNVLFAHL-DDNE-RSDIFDAMF PVQHI----AGEYIIKQG--DDGDNFY--VM-DQ--GEVDIII-NN--N----YITTLGD GASFGELALIYGTPRAADV--R-------------------------------AKTD-LK LWAIDRDSYRRILM--GSTLKKRKMYDEFLSK-VSIL-ESLDKWERLTVADALEPAQFES GQEVVVQGDSGSDFYIIVEGTAAVLQRRSD------NEEYTQVGTLGASDYF-G-EIALL L--DRPRAATVVA--RSV-LKCVKLDRPRFERVLGECSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SYVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_aegypti_AAEL002277-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MFDQLKK--------------------------------K VYRRQQKL----EQAKLDASK--------------------------------------- ----------------------QAAS----PDDLDDLS--PMPQ---------------- ----------TTAPPV-RRR-GG--ISAEPVSEE---DAT----SYVK------------ -------------------KVVPKDYKTMAALSKAIAKNVLFAHL-DENE-RSDIFDAMF PCTFL----PGESIIQQG--DEGDNFY--VI-DI--GEVEVFV-NN--E----LVTTISE GGSFGELALIYGTPRAATV--R-------------------------------AKTD-VK LWGIDRDSYRRILM--GSTIRKRKMYEEFLSR-VSIL-ESLDKWERLTVADALEPVSFED GETIVRQGEPGNDFYIIVEGCATVRQKRDE------NEEPAEVGRLGPSDYF-G-EIALL L--DRPRAATVIA--RGP-LKCVKLDRARFERVLGLCADILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000095574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NEASQVGTQKSLLSLHC-INNDFSSDIFDAMF PVTHI----AGETVIQQG--DEGDNFY--VI-DQ--GEVDVYV-NG--E----WVTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIIIEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000002916 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SDIFDAMF PVNHI----AGETVIQQG--DEGDNFY--VI-DQ--GEADVYV-NG--E----WVTNIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GEKIVVQGEPGDDFFIITEGTASVLQRRSD------NEEYVEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000003303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MF PVTHI----AGETVIQQG--DEGDNFY--VM-DQ--GEVDVYV-NG--E----WVTSISE GGSFGELALIYGTPRAATV--K-------------------------------AKTD-LK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLEKWERLTVADALEPVQFED GEKIVVQGQPGDDFFIITEGTASVLQRRSP------NEEYMEVGRLGPSDYF-G-EIALL L--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSEILKRSI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QRYN--------------------------------------- SFISLTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_elegans_R07E4.6c MN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NYSGDIVFMSGGNEEDQLAQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CQAYVQRHNIQQLVKEA--------------IVVLCIHKPDNPVLFLK DHFEKLNE----QRAQEGGNP--------------------------------------- ------------------------------DAADDDDIIVEPPK---------------- -------------RSG-GRR-TG--ISAEPIKED---DT-----EYKK------------ -------------------VVIPKDDATRRSLESAMRKNLLFAHL-EEDE-QKTMYDAMF PVEKS----AGETIIEQG--EEGDNFY--VI-DK--GTVDVYV-NH--E----YVLTINE GGSFGELALIYGTPRAATV--I-------------------------------AKTD-VK LWAIDRLTYRRILM--GSVTKKRKMYDEFLSK-VQIL-ADLDQWERANVADALERCDFEP GTHVVEQGQPGDEFFIILEGEANVLQKRSD------DAPFDVVGHLGMSDYF-G-EIALL L--DRPRAATVVA--KTH-LKCIKLDRNRFERVMGPVREILKRDV--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SNYN--------------------------------------- SYVKLMT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000024459 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------QVIPKDYKTMAALAKAIEKNVLFAHL-AGNS-H-DIFDAMF SVTYI----AGETVIQQG--DEGDNFY--VV-DQ--GEMDVYV-NN--D----WMTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL-ESLDKWERLTVADALEPVQFED GQKIVVQGEPGDEFFIILEGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-E---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000039632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LPQ----EEARQTLNQ--------------------------------------- ----------------------QKSG-SRSDSREDEISPPPHMN---------------- ----------SVVKGR-RRR-GA--ISAEVYTEE---DAA----SYVR------------ -------------------KVIPKDYKTMAALAKAIEKNVLFAHL-DDNE-RSDIFDAMF SVTYI----AGETVIQQG--DEGDNFY--VV-DQ--GEMDVYV-NN--D----WMTSIGE GGSFGELALIYGTPRAATV--K-------------------------------AKTN-VK LWGIDRDSYRRILM--GSTLRKRKMYEEFLSK-VSIL----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gorilla_ENSGGOP00000016110 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------RSLRE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------CELYVQKHNIQALLKDS--------------IVQLCTAXPERPMAFLR EYFERLEK----XXXXXXXXX--------------------------------------- ----------------------XXXX-XXXXXXXXXXXX-XXXX---------------- ----------XXXXXX-XXX-XX--XXXXXXXXX---XXX----XXXX------------ -------------------XVIPKDYKTMAALAKAIEKNVLFSHL-DDNE-RSDIFDAMF SVSFI----AGETVIQQG--DEGDNFY--VI-DQ--GETDVYV-NX--X----XXXXXXX XXXXXXXXXXXXXXXXXXX--X-------------------------------XXXX-XX XXXXXXXXXXXXXX--XXXXXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXGSAAVLQRRSE------NEEFVEVGRLGPSDYF-G-EIALL M--NRPRAATVVA--RGP-LKCVKLDRPRFERVLGPCSDILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QQYN--------------------------------------- SFVSLSV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_melanogaster_FBpp0087524 MSSDSSRRIQVP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EELKEVLLQF--------------SISFLVEQPPDVIDYAV EYFTKLQS----ERPSVSHTDQST------------------------------------ ---------------------DDQLSVNS---------QDADAE---------------- ----------PPVMAS-SRR-KS--VFAEAYDPEAD-DDD----DGAT------------ -------------------AVFPKTDEQRARLVESVKNVLLFRSL-EKEQ-MNQVLDAMF ERKVQ----PGDFIIRQG--DDGDNFY--VI-ES--GVYKVYI-ND--K----HINTYNH TGLFGELALLYNMPRAATV--Q-------------------------------AETS-GL LWAMDRQTFRRILL--KSAFRKRKMYEELLNS-VPML-KALQNYERMNLADALVSKSYDN GERIIKQGDAADGMYFIEEGTVSVRMDQ--------DDAEVEISQLGKGQYF-G-ELALV T--HRPRAASVYA--TGGVVKLAFLDVKAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------DDYE--------------------------------------- SQLVKIF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSKNN ITDTR------------------------------------------------------- ----------------------------- >C_familiaris_ENSCAFP00000005888 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLDFAL QHFTRLQQ----ENERRGAARFGHEARTWGDAGA-AA------GGGTPSKGVNFAEEPAR ------------TDSEDA----EEEEEAA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-EDGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000047706 --------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGTARFGHEGRTWGDLGA-AA------GGGTPSKGVNFAEEPMH ------------SDSEDG---EEEEAAPA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----DGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEFSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000265717 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGTARFGHEGRTWGDLGA-AA------GGGTPSKGVNFAEEPMQ ------------SDSEDG---EEEEAAPA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----DGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEFSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000012415 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGAARFGHEGRTWGDAGA-AA------GGGTPSKGVNFAEEPMR ------------SDSENG-----EEEEAA---------EAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVRITMKRKGKSDIE-ENGAVEIARCLRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000003079 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGAARFGHEGRTWGDAGA-AA------GGGIPSKGVNFAEEPMR ------------SDSENG-----EEEEAA---------EAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYND GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCFRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000019916 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQE----ENERKGAARFGHEGRTWGDAGA-AS------GGGTPSKGVNFAEEPRH ------------SDSENG---EEEEEEAA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYND GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000020202 -X------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGTARFGHEGRTWGDAGA-SAAA---VGGGTPSKGVNFAEEPMH ------------SDSEDG---EEEEAAPA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----DGEHVIDQG--DDGDNFY--VI-DR--GTYDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEFSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000005022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------DGHM--EPEKGQRR---------LPRMME---------------- ---------SPVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRTRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRRMYENFIES-LPFL-KSLDVSERLKVVDVIGTKIYKD GEQIIAQGDLADSFFIVESGEVKITMKRKNKQEVE-ENDSVEIARYSRGQYF-G-ELALV T--NKPRAASAYA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IADP-------------------------------------------------------- ----------------------------- >M_domestica_ENSMODP00000020466 -S------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQSF--------------TVEVLRHQPGDLLEFAL QHFTRLQQ----ENRYKG----GHGAVDRASAGAGAV------GGGTPSRGVNFADEPVQ ------------TESENG---EEEDDDEE---------QQSGDT---------------- ---------APVLNRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTYDIYV-KC--DGVGKCIGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRRMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYKD GEQIIAQGDSADSFFIIESGEVKISMKRKNKQEVE-ENGAIEIARYSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD I----------------------------------------------------------- ----------------------------- >M_domestica_ENSMODP00000016745 -------HIEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRNHPEDLVDFAV DYFTRLRE----NRRLGEDGEKDEGRGD---------------EEDEHAGPSSHPDLPFP --------------LHSSEPGKPASL------------CQFFLS---------------- ---------APVINRY-NRR-VS--VCAESFNPDE--EDD----TEPK------------ -------------------VIHPKSDEQRSRLQEACKDILLFKNL-DQEQ-LSEVLDAMF ERIVV----SEEHVIDQG--DDGDNFY--VI-ER--GKYDILV-TK--ENQSFRVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------AITE-GS LWGLDRITFRRIIL--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKNYKD GEQIIAQGDKAESFYIVESGEVKILIKSKTNKD---TEDEVEIARCQKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SNYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LSDPGN------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000003190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------FAEEAML ------------TDSESGE--FEQPSPPP---------PPQQFP---------------- ---------APAVNRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKMVE----GGEHVIDQG--DDGDNFY--VI-DK--GTYDIYV-KC--DGVGRCVGTYDN RGCFGELALMYNTPRAATI--I-------------------------------ATSP-GS IWGLDRVTFRRIIV--KNNAKKRRMYESFIES-LPFL-KSLEMSERLKVVDVIGTKVYKD GEQIIAQGDLADSFFIVESGEVRIIMTRKGKQDLE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAFA--LGT-VKCLVMDVQAFERLLGPCMEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IADTSA------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000023083 MS-----KFEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLKELLQGY--------------TVEVLRRRPANLAQFAV QHFTQVLE----SQRNEQAAESHSTGP----------------------AEEEEDDDAFE ------------TASNPSISDEDEE-------------EERNIV---------------- ---------KAKADRC-SRR-VA--VCAETYNPDEDEDND----TEPQ------------ -------------------VVHPKTDEQRQRLQDACKDILLFKTL-AKEQ-FSEVLDAMF EVLVK----PEEHIIDQG--DDGDNFY--VI-EK--GVFDIYV-QK--DGLNVCVGKYNN KGSFGELALMYNTPRAATI--V-------------------------------AKQD-GA LWALDRATFHRLIV--KNNAKKRRMYEAFIEC-VPLL-KSLELSERMKIVDVLGVRTFSD GERIITQGDKADCFFIVESGEVKIMIKSK-KAGQP-DGVEVEVARCSRGQYF-G-ELALV T--NKPRAATAYA--VGD-TKCLVIDIQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SQYK--------------------------------------- DQLMALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------G---- ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000014732 MS------ISVP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EGLTELLQGF--------------TVEVLRSQPGDLLDFAL QYFGRLKA----EEEENGEADVGRLHA--ASPGT-PR------GKQAPRGGVNFAEEPMQ ------------TDSESG---EGDED--G---------EAEGFP---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----ADSK------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKSVE----GGEHVIDQG--DDGDNFY--VI-DW--GTYDIYV-KC--EGVGRCVGTYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA VWGLDRVTFRRIIV--KNNAKKRRMYESFIES-LPFL-KSLELSERLKVVDVIGTKIYKD GEQIIAQGDMADCFFIIESGEVKITMKRKGKQDVD-ENEAVEITRYTRGQYF-G-ELALV T--NKPRAASAFA--LGT-VKCLVRDVPAFER-LGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IADPSA------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000009806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVN----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEVSERLKVVDVIGTKVYSD GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEAE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >A_gambiae_AGAP004940-PA MSSQQKHRIQVP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DGLRDVLLEF--------------SIAYLLEQPGDVIDYAV TFFTKLQE----DRKTTMITSAEPT----------------------------------- ---------------------SPDESIMS---------HDEGRY---------------- ---------KPLVNRYASRR-KS--VFAETYDPEND-DED----EGAR------------ -------------------AIFPKTDEQRARLCDSVKNILLFRSL-DKEQ-MNEVLDAMF EKIVQ----AKDYIIKQG--DDGDNFY--VI-ES--GIYNAYV-GE--D--QKHIHTYDN RGSFGELALLYNMPRAATI--Q-------------------------------AETD-GK LWAMDRQTFRRILL--KSAFRKRKMYEALLDA-VPML-KTLQNYERMNLADALIPQTYAK GDRIIKQGDAADGMYFIEDGKVSIRIQQ--------DAGEVEISNLEKGGYF-G-ELALV T--HRPRAASAYA--VDN-VKVAFLDVDAFERLLGPCMNIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GDYE--------------------------------------- TQLVKIF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSKNN ITDIR------------------------------------------------------- ----------------------------- >C_familiaris_ENSCAFP00000017836 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVDFAV DYFTRLRE----ARLQASSPPAAPPSGS-----------------------QGLEPSPGL ---------------VADAKADSESE------------DDEDLD---------------- ---------VPIPSRF-DRR-VSDLVCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDQQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERTVK----VDEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRRMFESFIES-VPLL-KSLEMSERMKIVDVIGEKAYKD GERIITQGEKADSFYIIESGEVSILIRSKTKANKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LIDPGQ------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000018886 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQRPPDLVDFAV DYFTRLRE----ARSRASTPPAAPPSGS-----------------------QDFDPGAGL ---------------VADAVADSESE------------DEEDLD---------------- ---------VPIPGRF-DRR-VS--VCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDQQRCRLQEACKDILLFKNL-DPEQ-LSQVLDAMF ERTVK----VDEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN HGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKVYKD GERIITQGEKADSFYIIESGEVSILIKSKTKVNKDGENQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LIDPGQ------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000019115 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EGLTELLQSF--------------TVEVLRNQPRDLLQFAL QYFTQLKE----AESKEAPFGNDQN------------------SAPRSGKAVNFIDEAMQ ------------IDSENGEDPNISPSEPWW--------KRGANS---------------- ---------APVINRF-SRR-AS--VCAEAFNPDED-EEE----KEPL------------ -------------------VTHPKTDEQRQRLQEACRDILLFKNL-DPEE-MSQVLDAMF EKFCT----EGEHIIDQD--DDGDNFY--VI-ES--GTFSIFV-KT--DSTEKLVGCYDN RGSFGELALMYNTPRAATI--I-------------------------------ATST-GA LWCLDRLTFRRIIV--KNNAKKRKMYESFIET-LPLL-TSLELSERMKVVDVISSKVFSD SQQIIVQGDLADCFYIVESGQVRITIKRGRTKKDP-EEEEVDIATLSRGQYF-G-ELALV T--NKPRAASAYA--VGS-VKCLVMDVKAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVTLF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSTA IEQRSQ------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000265563 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVEFAV EYFTRLRE----ARAPASVLPAATPRQS--------------------LGHPPPEPGPDR ---------------VADAKGDSESE------------EDEDLE---------------- ---------VPVPSRF-NRR-VS--VCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERIVK----ADEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKIYKD GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LGNLGQ------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000023587 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGLTELLQGF--------------TVEVLRQRPSDLVDFAV QYFTRLRD----TKSQDGSG-----------------------AAGKTGKGVMFDGEPMQ ------------TESNGEDDED----------------DDSDFELLKSLHRPRNDEKKHK KLPCSYTFRAPPPSRF-NRR-VS--VCAEAFNPDED-DED----SEPR------------ -------------------VVHPKTDVQRCRLQEACRDILLFKTL-DQEQ-FSQVLDAMF ESRVQ----AQEHVIDQG--DDGDNFY--VI-ER--GVFDIVV-S------GNCVGQYNN KGSFGELALMYNTPRAATI--I-------------------------------ATQE-GA LWGLDRATFRRLIV--KNNAKKRRMYETFIES-VPLL-KSLEVTERMKLVDVLGAKQFSD SERIITQGDKADCFYIVESGEVKIMMKSKTKAGHA-DNAEVEITRCSRGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVVDVQAFERLLGSCKEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AHYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LRD--------------------------------------------------------- ----------------------------- >G_gallus_ENSGALP00000013072 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EAYNPDEE-EDD----AETR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVE----GGEHVIDQG--DDGDNFY--VI-DR--GTYDIYV-KC--DGVGRCVGTYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA IWGLDRVTFRRIIV--KNNAKKRRMYENFIES-LPFL-KSLEVSERLKVVDVIGTKVYKD GEQIIAQGDMADSFFIVESGEVRIIMTK--------ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAFA--LGT-VKCLVMDVQAFERLLGPCMEILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IADTS------------------------------------------------------- ----------------------------- >R_norvegicus_ENSRNOP00000027552 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVDFAV EYFTRLRE----ARRQESDSFIAPPTTF-----------------------HAQESSGVP ---------------VIEEDGESESDS-----------DDEDLE---------------- ---------VPIPSKF-TRR-VS--VCAETFNPD-E-EED----NDPR------------ -------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF EKIVK----TDEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSD-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLF-KSLEMSERMKIVDVIGEKIYKD GERIITQGEKADSFYIIESGEVSILIRSKTKTNKNGGNQEVEIAHCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSNLD LLDPGQ------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000035220 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGY--------------TVEVLRQQPPDLVDFAV EYFTRLRE----ARRQESDTFIVSPTTF-----------------------HTQESSAVP ---------------VIEEDGESDSDS-----------EDADLE---------------- ---------VPVPSKF-TRR-VS--VCAETFNPDEE-EED----NDPR------------ -------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF EKIVK----TDEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLF-KSLEMSERMKIVDVIGEKIYKD GERIIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSNLD LMDPGQ------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000003826 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGLTELLQGY--------------TVEVLRQRPSDLVEFAV QYFTRLRD----SRARQNAILISSPQRFHIKES----------TGGRISIEWDLNSKQKY --------------------------------------ETKNQN---------------- ---------APPPSRF-NRR-VS--VCAEAFNPDDD-DED----TEPR------------ -------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQEQ-FSQVLDAMF ELKVQ----PQEHVIDQG--HDGDNFY--VI-ER--GIYDIVV-S------GKCVGQYNN KGSFGELALMYNTPRAATI--I-------------------------------ATQE-GA LWGLDRATFRRLIV--KNNAKKRRMYETFIES-VPLL-KTLEPNERMKIVDVLGMKQFLD GERIIAQGEKAECFYIVESGEVKIMMKSKTKADHA-DNAEVEITRCSRGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVIDVQAFERLLGSCKEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LRD--------------------------------------------------------- ----------------------------- >D_rerio_ENSDARP00000048675 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DLFL--- ------------------------------------------------------------ --------------------------------------SVFLST---------------- ---------APPPSRF-NRR-VS--VCAEAFNPDDD-EED----SEPR------------ -------------------VVHPKTDEQRCRLQEACKDILLFKAL-DQEQ-FSEVLDAMF EVLVQ----PQDHVIDQG--DDGDNFY--VI-ER--GVYDIVV-QK--DGVGCCVGQYNN KGSFGELALMYNTPRAATI--I-------------------------------AKDE-GA LWGLDRATFRRLIV--KNNAKKRRMYECFIES-IPLL-KSLELSERMKIVDVLGVKTFQD GERIIMQGDKADCFYIVESGEVKIMMKSKTKADRQ-DNAEVEIARCSRGQYF-G-ELALV T--NKPRAASAYA--IGD-VKCLVIDIQAFERLLGPCKEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AHYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LRD--------------------------------------------------------- ----------------------------- >T_guttata_ENSTGUP00000009429 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRHRPSDLLGFAA EYFARLRD----ARDQEAGGGR---------------------------RGRFPAGQGGQ RAGIEWGRGSAGSRSPAPPLPGRCRSAPGAPHA-----PSLGPE---------------- ---------SPVVNRY-NRR-VS--VCAEAFNPDEE-EED----TEQR------------ -------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERKVK----PQEHVIDQG--DDGDNFY--VV-ER--GVYDIVV-AK--DNQSRCVGRYDN HGSFGELALMYNTPRAATI--V-------------------------------ATTE-GA LWGLDRVTFRRIIL--KNNAKKRKTYELFIES-VPLL-KSLEPSERMKIVDVIGEKVYQD GERIISQGDKADCFYIVESGEVKILIKSKGNSVKE-ANQEVEIARCHRGQYF-G-ELALV T--NKPRAASAYA--VGE-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------THYE--------------------------------------- EQLVAMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LMDPGN------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000011344 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRHRPADLVGFAA DYFTRLRD----AREQEATGDGR--------------------------RVISFDGEPMQ ------------TESNGEEEPERGDEE-----------SDSDFE---------------- ---------PPVINRY-NRR-VS--VCAEAFNPDEE-EED----TEQR------------ -------------------IVHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERKVK----PHEHVIDQG--DDGDNFY--VI-EE--GLYDIVV-AK--DNQARCVGRYDN HGSFGELALMYNTPRAATI--V-------------------------------ATTE-GA LWGLDRVTFRRIIL--KNNAKKRKTYELFIES-VPLL-KSLEASERMKIVDVIGEKVYQD GERIISQGDKADCFYIVESGEVKIMIKSKTMMSKE-ANQEVEIARCHRGQYF-G-ELALV T--NKPRAASAYA--VGE-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------THYE--------------------------------------- EQLVAMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LMDPGN------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000007645 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGLTELLQGY--------------TVEVLRQRPSDLVDFAV QYFSRLRD----TRSQDGDT-----------------------AGGKTAKDSDFERGAFL ------------TVKNCSADGEVRD-------------GPQVDR---------------- ---------APPPSRF-SRR-VS--VCAEAFNPDDD-DED----TEPR------------ -------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQEQ-FSEVLDAMF ELRVQ----PLEHVIDQG--DDGDNFY--VI-ER--GVYDIMV-------MGTTVGQYNN KGSFGELALMYNTPRAATI--A-------------------------------ATEE-GA LWGLDRATFRRLIV--KNNAKKRRVYEAFIES-VPLL-KSLEANERMKIVDVLGSKQFPD GERIITQGDKAECFYIVESGEVKIMMKSKTKADHA-DNAEVEITRCSRGHYF-G-ELALV T--NKPRAASAYA--VGD-VKCVVIDIQAFERLLGSCKEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AHYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LRD--------------------------------------------------------- ----------------------------- >X_tropicalis_ENSXETP00000020557 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTDLLQGY--------------TVEVLRQKPPDLVEFAI QYFTRLKE----KQLQDGAGAGSLR---------------------PHARVVNFDGEPMQ ------------TESNGDEEEDEEDD------------DDSDFE---------------- ---------PPVINRY-SRR-VS--VCAEAYNPDEE-DED----TEPR------------ -------------------VVRPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF EMRVK----PQEHVIDQG--DDGDNFY--VV-ER--GQYDIFV-ER--DGQSRCVGRYDN HGSFGELALMYNTPRAATI--V-------------------------------ATSE-GA LWGLDRVTFRRIIL--KNNAKKRKTYEIFIES-VPVL-KFLELSERMKIVDVIAARVYKD GDRIIAQGDKADCFFIVESGEVKIMMKSKTKTGQE-SNQEVEIARCKSGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLIMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------THYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LRDPGK------------------------------------------------------ ----------------------------- >C_intestinalis_ENSCINP00000014963 MG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SATNQDDEEMVASDNDDYMDEAEEMAMM---------------- ----------ARRTNV-SRR-KS--VSAEGFDPDAD-DDD----DEEK------------ -------------------VIHPKTDEQRDRLSKVISKMLIFSSL-DIEQ-TQQVLDAMF EKSVK----AGDHVIDEG--DDGDNFY--VI-EK--GDFDIFI-NDPVTKVPDHKGTYKG SGAFGELALMYNCPRLATI--I-------------------------------ATTD-GS LWGMDRTTFRRIIV--KNAAKKRKQYEDFLAT-VPLL-STLTVEERMKVADAMVTKNYED EDCILKQGDPADYFYIVIDGQVVVKRRGDDPSN---ANHEVVLKKYTNGEYF-G-ELALI Q--NQPRAASAFA--EGP-CKCAVLDVQAFERLLGPCKELLMRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------PLYE--------------------------------------- QQLSEIY----------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------QDMS MSE--------------------------------------------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000020060 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGTARFGHEGRIWGDVGA-AA------GGGTPSKGVNFAEEPMH ------------SDSEDG---EEEEAAPA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ ------------------------------------------------EQ-MSQVLDAMF EKLVK----DGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLDRVTFRRIIV--KNNAKKRKMYESFIES-LPFL-KSLEFSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLAMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD IVEPTA------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000011863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VCAEAYNPDEE-DED----TEPR------------ -------------------VVHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERKVQ----PQEHVIDQG--DDGDNFY--VI-ER--GLYDIFV-AR--DGQTRCVGRYDN HGSFGELALMYNTPRAATI--V-------------------------------ATTE-GA LWGLDRVTFRRIIL--KNNAKKRKTYELFVES-VPLL-KSLEPSERMKIVDVIGEKVFQD GERIICQGDKADSFYIVECGEVKILIKSKTITGKD-ANQEIEIARCQKGQYF-G-ELALV T--NKPRAASAYA--VGE-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------THYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LTNPGN------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000000105 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVEFAV DYFTRLRE----ARAPASVLPAATPRQS--------------------PGHPPPEPGPDR ---------------VADAKGDSESE------------EDEDLE---------------- ---------GAIPSRF-VLK-CS--VCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERIVK----ADEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKIYKD GERIITQGEKADSFYIIESGEVSILIRSKTKSNKDGGNQEVEIARCH-GQYF-G-ELALV T--NNPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD LGNLGQ------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000013024 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EGLTELLQSF--------------TVEVLRKQPEDLLEFAL QYFTQLKQ----SKSQGGPLSHGMELPF------------------RLTKGVIFAEEPMQ ------------TDSENGEEEEDDDE------------EDFVGV---------------- ---------RPFVPAF-HMQ--G--IGFSTLFSQAV-TEL----KLPA------------ -------------------VIYPKTDDQRNRLQEACKDILLFKSL-DQEQ-MSQVLDAMF EKLVK----CGEHVIDQG--DDGDNFY--VI-DR--GTYDIFV-KS--DGVVRCVGAYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSV-GS IWGLDRATFRRIIV--KNNAKKKRMYENFIES-LPFL-KSLEFSERLKVVDVIGTKTYYD GEQIIAQGDGADSFYIVESGEVRINMKSKSKPDAE-TNEAVEIARYTRGQYF-G-ELALV T--NKPRAASAYA--VGN-VKCLVMDVQAFERLLGPCMEIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GTNMD ITDPST------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000043508 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------APVINRF-CRR-AS--VCAEAFNPDED-EEE----KEPL------------ -------------------VTYPKTDEQRQRLQEACRDILLFKNL-DPEE-MSQVLDAMF EKFCT----EGEHIIDQD--DEGNNFY--VI-ES--GTFSIFV-KT--DSTEKLVGCYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA LWCLDRLTFRRIIV--KNNAKKRKMYESFIET-LPLL-TSLELSERMKVVDVISSKVFND SQQIIAQGDLADCFYIVESGQVRITIKRSRTKKDP-EEEEVDIAALSRGQYF-G-ELALV T--NKPRAASAYA--VGS-VKCLVMDVKAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVTLF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSTE I----------------------------------------------------------- ----------------------------- >E_caballus_ENSECAP00000017462 MA-----DQVKPISPLKNLLAGGFGGMCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGT FDCFRKTLIREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKCPEDVLSYPQLFA AGMLSGVFTTGIMTPGERIKCLL------------------------------------- ------------------------------------------------------------ ------------------------------------------QIQASSGDTKYTGPLDC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AKKVYQESGIRGIYKGT--------------VLTLMRDVPASGMYFMT --YEWLKN----IFTPEGKSVNELSVPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG ----------------------------KYPNGFKDVLRELIRD---------------- ---------EGVTSLY-KGF-NA--VMIRAFPANAV-TPP----KVPY------------ -------------------SDF-------------------------PEQ-LSQVLDAMF ERTVK----VDEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN HGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKSYKD GERIITQGEKADSFYIIESGEVSILIKSKTKANKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSLD LIDPGQ------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000046625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------NDDD-----------DDNNYY---------------- ---------APVINRF-VRR-AS--VCAEAYNPDED-EEE----REPR------------ -------------------VTYPKTDEQRQRLQEACKDILLFKNL-DQEQ-MSQVLDAMF EKVVV----SGEHIIDQD--DDGDNFY--VI-ER--GMFEILL-KA--DGTTRTVGSYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA LWCLDRLTFRRIIV--KNNAKKRKMYEAFIGT-LPLL-TSLEVSERMKVVDVLSTKVYNG GEQIIAQGDLADCFYIVESGHVRITMKRSKSKNDT-EDEEVEIATCSRGQYF-G-ELALV T--NKPRAASAYA--MDS-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLITLF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSQIA IEEPNA------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000005487 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EGLTELLQSF--------------TVEVLRNQPRDLLEFAL QYFTQLKD----NETKEAAFGNDQN------------------SAPRSGKAVNFIDEAMQ ------------IDSENGEEEEDDDDD-----------DDEEFI---------------- ---------APVINRF-IRR-AS--VCAEAFNPDED-EED----KEPR------------ -------------------VTYPKTDEQRQRLQEACRDILLFKNL-DPEE-ISQVLDAMF EKFCT----EGEHIIDQD--DDGDNFY--VI-ES--GTFNIFV-KV--DGIEKLVGCYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA LWCLDRLTFRRIIV--KNNAKKRRLYEAFIET-LPLL-TSLETSERMKVVDVLSTRVYND SQQIIAQGDLADCFYIVESGQVRITMKRSRTKKDQ-EEEEVEIATCTRGQYF-G-ELALV T--NKPRAASAYA--VGS-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLQSLF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSPE IEQPSA------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000025724 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVEFAV EYFTRLRE----ARAPASVLPAATPRQS--------------------LGHPPPEPGPDR ---------------VADTKGDSESE------------EDEDLE---------------- ---------VPVPSRF-NRR-VS--VCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERIVK----ADEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DDQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKIYKD GERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCL--------RLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LGNLGQ------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000028483 MS-----KQQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVRLQTQPKPKPGETLLYKGT FDCFKKTLAKEGLKGLYKGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPDDILTYPQLFA AGMLSGVFTTAIMTPGERIKCLL------------------------------------- ------------------------------------------------------------ ------------------------------------------QIQASTGNVKYNGPMDC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VKQLYRESGIRGIYKGT--------------ALTLMRDVPASGMYFMT --YEWLKT----LLTPPGKSHNELSIPSILFAGGMAGIFNWAVAIPPDVLKSRFQTAPEG ----------------------------KYPNGFRDVLRELIRE---------------- ---------EGVASLY-KGF-NA--VMLRAFPANAA-APV----TQRC------------ -------------------CSL-------------------------QEQ-FSEILDAMF EVLVK----PQQHIIDQG--DDGDNFY--VI-ET--GTFDIFV-KK--DGANLCVGKYDN KGSFGELALMYNTPRAATI--V-------------------------------ATQD-GA LWALDRATFHRLIV--KNNAKKRRMYEAFIES-VALL-KSLELSERMKIVDALAARGFKD GERIITQGDDADCFYIVESGQVRIMIKSKTKVSEQ-NNVEVEVARCSRGHYF-G-ELALV T--NKPRAASVYA--VGE-TKCLVIDIQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SLYE--------------------------------------- DQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSDD L----------------------------------------------------------- ----------------------------- >G_aculeatus_ENSGACP00000001531 MS-----SVEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLKELLQGY--------------TVEVLRREPPDLVEFAV QHFTRILE----GQKKNRGAKKRST--------------------RPARKGVTFDTVSNK --------------PSKVDDDEEEEDTISDKNHTKDKEKLSSQK---------------- ---------QSTTSKY-NRR-VS--VCAEAYNPDDDEDDD----AELR------------ -------------------IVYPKTDVQRRRLQDACRDILLFKTL-EQEQ-FSEVLDGMF EVLVK----PQEHIIDQG--ADGDNFY--VI-EK--GVYDILV-QK--GGVSVCVGKYDN KGSFGELALMYNTPRAATI--I-------------------------------ATQE-GA LWGLDRATFHRLIV--RNNAKKRRTYEAFIEC-VPLL-KSLELSERMKIVDVVGARVFKD GERLITQGEEADCFYVVESGEVKIMITSQAKAG---QQDEVEVARCSRGQYF-G-ELALV T--NKPRAASVYA--VGE-TKCLVIDIQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SQYE--------------------------------------- EQRVALM----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000013289 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EGLTELLQSF--------------TVEVLRNQPRDLLEFAL QYFTQLKE----RETTQASFGNDQN------------------SAPRPVKAVNFIDEAMQ ------------MDSENGEELVDIYT--------------YASA---------------- ---------APVINRF-IRR-AS--VCAEAFNPDDD-DED----KEPW------------ -------------------VIHPKTDDQRQRLQEACWDILLFKNL-DPEE-MSQVLDAMF EKFCT----EGEHIIDQD--DDGDNFY--VI-ES--GTFKIFV-KV--DGTDKLVGCYDN RGSFGELALMYNTPRAATI--I-------------------------------ATSP-GA LWCLDRLTFRRIIV--KNNAKKRRVYEAFIET-LPLL-TSLELSERMKVVDVISTKTYSD SQQIIAQGDLADCFYIVESGQVRITMKRSRTKKDQ-EDEEMDIATCMRGQYF-G-ELALV T--NKPRAASAYA--VGS-VKCLAMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ANYE--------------------------------------- EQLVTLF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSTG MEQQSA------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000006288 MS------VPVP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLPELLRGF--------------TLEVLRRQPADLLEFSV RYFTGLRD----TRSSTRSASSRS----------------------PVTRGEAFDRDSAH ------TDSSVEEEEKPEEEEEEEEKPEEEDEEEDDFPDDFTFK---------------- ---------APPPSKC-NRR-VS--VCAEPYNPDED-DDDGDEGSQLT------------ -------------------VLHQKTDEQRQRLQDACKHILLFKTL-EEDQ-LAEVLDSMF EVLVK----PGECIINQG--DDGDNFY--VI-ER--GVYEIVI-QQ--DGLQHSVGRYDH KGSFGELALMYNTPRAATI--R-------------------------------ALQE-GA LWALDRATFHRLIV--KNNAKKRRMYESFIEC-VPLL-KSLQLSERMKIVDVLGMRSFSD GERIIQQGDSADCFYIVESGEVRIMIRSKTRACQL-LQEEVEVARCSRGQYF-G-ELALV T--KRPRAASVYA--VGD-TRCLVIDVQAFERLLGSCKQILKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------THYE--------------------------------------- QQLVAVF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LKH--------------------------------------------------------- ----------------------------- >A_aegypti_AAEL009216-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------EPLVNRYASRR-KS--VFAETYDPEAD-DDD----DGAR------------ -------------------AIFPKTDEQRARLCDSVKNILLFR-L-MNTI-MNEVLDAMF EKKVK----AKDYIIKQG--DDGDNFY--VI-ES--GIYKAYV-GE--D--QKHIHTYDN SGSFGELALLYNMPRAATI--Q-------------------------------AETD-GQ LWAMDRQTFRRILL--KSAFRKRKMYEALLDA-VPML-KTLQSYERMNLADALIPKTFAK GERIIKQGDAADGMYFIEEGKVSIRIQQ--------DAGEVEISNLEKGQYF-G-ELALV T--HRPRAASAYA--VDN-VKVAFLQTDCFERLLGKVLDVMLRGM--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------KHYR--------------------------------------- YVDQSVWK---------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------MILEACREE NSQVR------------------------------------------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000015541 MS-----HIQIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PGLTELLQGY--------------TVEVLRQQPPDLVEFAV DYFTRLRE----ARAPASVLPAATPRQS--------------------LRHSTLEPGPDR ---------------VADAKGDSESE------------EDEDLE---------------- ---------VPVPSRF-NRR-VS--VCAETYNPDEE-EED----TDPR------------ -------------------VIHPKTDEQRCRLQEACKDILLFKNL-DQEQ-LSQVLDAMF ERIVK----ADEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSERMKIVDVIGEKIYKD GERIITQ----------------------TKSNKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VKCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LGNLGQ------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000017695 MS-----KQQKPISPLKNFFAGGFGGVCLVFAGHPLDTIKVRLQTQPKAKPGETLLYRGT FDCFKKTLAKEGVRGLYKGMAAPIIGVTPMFAVCFFGFGLGKKLQQKSPDDVLTYPQLFA AGMLSGVFTTAIMTPGERIKCLLQ------------------------------------ ------------------------------------------------------------ ------------------------------------------QIQASTGKVKFNGPIDC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VKQLYRESGIRGIYKGT--------------ALTLMRDVPASGMYFMS --YEWLKN----DLTPPGKSHNELSVPSILFAGGMAGIFNWAVAIPPDVLKSRFQTAPEG ----------------------------KYPNGFRDVLRELVRE---------------- ---------EGVASLY-KGF-NA--VMLRAFPANAS-PPP----ANPT------------ -------------------AEF-------------------------PEQ-FSEILDAMF EVLVK----PQQHIIDQG--DDGDNFY--VI-EK--GTFDIFV-QK--DGASLCVGKYDN KGSFGELALMYNTPRAATI--V-------------------------------ATQE-GA LWALDRATFHRLIV--KNNAKKRRMYEAFIES-VPLL-KSLELSERMKIVDVLAARSFKD EERIITQGDEADCFYIVESGQVKIKIKSKTKVSEQ-NNGEVEVARCVRGQYF-G-ELALV T--NKPRAASVYA--VGE-TKCLVIDIQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SLYE--------------------------------------- DQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSED L----------------------------------------------------------- ----------------------------- >T_nigroviridis_ENSTNIP00000014986 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VGLTELLQGF--------------TVEVLRQRPSDLVDFAV HYFTRLRD----TKSQDGAG-----------------------AGGKMGKGVMFDGEPMQ ------------TESNGEDDED----------------DDSDFE---------------- ---------PPPPSRF-NRR-VS--VCAEAFNPDED-DED----SEPR------------ -------------------VVHPKTDEQRCRLQEACRDILLFKTL-DQEQ-FSQVLDAMF ESRVQ----PQEHVIDQG--DDGDNFY--VI-ER--GVFDIVV-S------GNCVGQYNN KGSFGELALMYNTPRAATI--V-------------------------------ATQE-GA LWGLDRATFRRLIV--KNNAKKRRMYETFIES-VPLL-KSLEATERMKLVDVLGAKQFSD SERIITQ----------------------TKADHA-DNAEVEIARCSRGQYF-G-ELALV T--NKPRAA-AYA--VGD-VKCLVIDVQAFERLLGSCKEIIKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AHYE--------------------------------------- EQLVALF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSMD L----------------------------------------------------------- ----------------------------- >S_cerevisiae_YIL033C MV------SSLP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KESQAELQLF--------------QNEINAANPSDFLQFSA NYFNKRLEQ---QRAFLKAREPEFKAKNIVLFPEPEESFSRPQSAQSQSRSRSSVMFKSP FVNEDPHSNVFKSGFNLDPHEQDTHQQAQEEQQHTREKTSTPPL---------------- ----------PMHFNA-QRR-TS--VSGETLQPNN--FDD----WTPD------------ -------------------HYKEKSEQQLQRLEKSIRNNFLFNKL-DSDS-KRLVINCLE EKSVP----KGATIIKQG--DQGDYFY--VV-EK--GTVDFYV-ND--N----KVNSSGP GSSFGELALMYNSPRAATV--V-------------------------------ATSD-CL LWALDRLTFRKILL--GSSFKKRLMYDDLLKS-MPVL-KSLTTYDRAKLADALDTKIYQP GETIIREGDQGENFYLIEYGAVDVSKKGQG-----------VINKLKDHDYF-G-EVALL N--DLPRQATVTA--TKR-TKVATLGKSGFQRLLGPAVDVLKLND--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------PTRH--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gorilla_ENSGGOP00000008988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PVPSRF-NRR-VS--VCAETYNPDEE-EED----TDPR------------ -------------------XXXXXXXXXXXXXXXXXXXXXXXXXX-XQEQ-LSQVLDAMF ERIVK----ADEHVIDQG--DDGDNFY--VI-ER--GTYDILV-TK--DNQTRSVGQYDN RGSFGELALMYNTPRAATI--V-------------------------------ATSE-GS LWGLDRVTFRRIIV--KNNAKKRKMFESFIES-VPLL-KSLEVSEXMKIVDVIGEKIYKD GERIITQXXXADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYF-G-ELALV T--NKPRAASAYA--VGD-VTCLVMDVQAFERLLGPCMDIMKRNI--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SHYE--------------------------------------- EQLVKMF----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GSSVD LGNLGQ------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000014875 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------DNGEEDREITPPS---------------- ----------PSWRRY-QRR-AS--VQAEAINPGEG-SSVSSPAGVRW------------ -------------------AQHPKSAEQMKRLKETCETLLPFREL-EEEL-LTQIFSAMF ERKVE----AQEHVVEQG--EDGDYFYAIAI-ES--GMYDLLV-AR--NKQDCRIGRYED RGAFGELALMYSYPRPATI--V-------------------------------ALTA-GV LWGLDRKTFRTITV--TFQAERRKKFESLINS-VPFF-RSLEKSEKMKLLDMIESKTYRH GDCIFAQGEMADKFYIVESGEVKMLTEMP-------TGKEVGIVKLNPGEYF-G-EGALV G--NKPRTSSAYA--VGD-AKCIVMNVEALERLLGPCLDILKRDM--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------AQFK--------------------------------------- -DLIALH----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------DSSVD LSEEHK------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000000553 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GGSTRAGVPSEGLSFQE ------------ERKEGGAPDGGGK----------------------------------- -------------------------------EEADPAGAGVAGA---------------- ----------VVRGRY-QRR-SS--IPAEAFGPSEGEEELMEETTVVW------------ -------------------AIYPKSEEQVRKLKEACKDLLPFRGL-EDEL-LLQIFSAMF EKKVL----PQEHVVEQG--EDGDHFY--VI-ED--GIFDVIV-QN--NSQHNIIGQYKH MGAFGELALMYSYPRPATI--V-------------------------------AITE-GS LWGLDRPTFRTITV--TFQLEKKKKIQMLLSN-VPFF-KSLEDTESVKILDVVEENNYQS GECIFPKGQTSDKFYIVESGEVKIVGEKL-------GSKEAEIVRHHEEDFF-G-ESALI S--NKPRTTSAYA--VGK-VKCIVMDVQALERVLGPYMDILKRDM--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SQYE--------------------------------------- -ELIKLL----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GPQID TKA--------------------------------------------------------- ----------------------------- >T_rubripes_ENSTRUP00000047709 T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQL AL----------QLKIEELRQRDALIDEL--------------ELELDTKDD-------- -LIRQLQI-------ELDRYRSSSQQALS-------SQ---------------------- -----------ETANT-------------------GAAVQTVFA---------------- ----------SDEP-LRIKR-QA--ISAEPSGL--D-PAKLTDVTL-------------- -------------------TSYLKTKESGELIQKALMNNDFMKHL-EHGQ-ILTIMDCMY PTTLS----KGCCVIQEG--DDGSTVY--VL-EE--GMVEVTK-QG--K----TLCTIGP GKVFGELAILYNCTRTASV--T-------------------------------ALTD-IK LWAIDRQNFQTIMM--RSGVIKHSQYMDFLRS-IPSF-QSLPEDGLSKLADVLEETHYGD SDYIIRQGATGDTFFIISEGQVKVSQQNSP------SDEQVTVTTLSKGDWF-G-EQALK G--EDVRTASYTA--VGD-VTCLVIDRESFKQLIGGLDEVKKKQC--------------- ----E----------NNEVKEK---------------------LQAEA-DFFSSVSLNDF N-----------------------------------------------------TI---- -CTLGMGGFSRVEL---VQLK-NETNRSFALKVLKKRHIVDTSQQGHILSERHIMMEAHS PFIVRLYR--------TFKDSKFLYMLLEACLGGELWTLLRDKGSFDDSTTRFYTGCVIE ALAFLHTRGIIYRDLKPENIILDNRGYAKLVDFGFAKKVGLGKKTWTFCGTPEYVAPEII LNKGHDSSADCWSLGILIFELLSGSPPFSGSDPMMTYNIILRGIDMIEFP-KKITKSAAT LIKRLC-RLSIVHIRINQKNGVKDIQKHKWFEGFNWEGLRQGNIDPPYTPTVDGPQDNSN FDYFPLDTDGPPPD------EESGWDLEF >T_rubripes_ENSTRUP00000026640 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ---------DL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DEDF AK----------ILLLKEERIRD-----L--------------ERRLADRED-------- -EIQELKR-------KLHKCQSVL-PSAQ------------------------------- ------------LI---------------------------------------------- -------------G-PRTRRAQG--ISAEPQTH-----QDLSRQTF-------------- -------------------RKYAKSDWSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-ES--L----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLTN-VK LWAIDRQCFQTIMM--RTGLIKQTEYMEFLKS-VPTF-QGLQEDILSKLADVLEETHYED GEYIIRQGARGDTFFIISKGKVNVTREDSP------SGEPVYLRSLGKGDWF-G-EKALQ G--EDIRTANVIA--AEA-VTCLVIDRDSFKHLIGGLEEVSSKGH--------------- ----E----------DADAKAK---------------------YEAEN-AFFFNLNLADF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKITKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPTVTSAVDISN FDNFPEDKEDPPPD------DNSGWDVDF >O_cuniculus_ENSOCUP00000010967 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGAARFGHEGRTWGDAGA-AA------GGGTPSKGVNFAEEPAH ------------SDSENGEEEEEEEEEAA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------XXXXKTDDPRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----EGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLXXXXXXXXXX--XXXXXXXXXXXXXXXX-XXXX-XXXXVSERLKVVDVIGTKVYND GEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCLATLLQAFERIY-PYMEIMHRKK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ATYQ--------------------------------------- EQLGAVL----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GEVMD IVEDHA------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000016594 T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQL AL----------QLKIEELRQRDALIDEL--------------ELELDTKDD-------- -LIRQLQI-------ELDRYRSSSQQALS-------SQ---------------------- -----------ETANT-------------------GAVVQAAPA---------------- ----------FDEP-LRIKR-QA--ISAEPSAL--D-PSKLTDVML-------------- -------------------TSYLKTKESGELIQKALMNNDFMKHL-EHGQ-ILTIMDCMY PTSLS----KGCCVIQEG--DDGSTVY--VL-EE--GMVEVTK-QG--K----KLCTIGP GKVFGELAILYNCTRTASV--T-------------------------------ALTD-IK LWAIDRQNFQTIMM--RSGVIKHSQYMDFLRS-VPSF-QSLPEDVLSKLADVLEETHYGD SDYIIRQGATGDTFFIISEGQVKVSQQGSP------SDEQVAVTLLSKGDWF-G-EQALK G--EDVRTASYTA--VGD-VTCLVIDRESFKQLIGGLDDVKNKQC--------------- ----E----------SNEVKAK---------------------LQAEA-DFFSSVSLKDF N-----------------------------------------------------II---- -CTLGMGGFSRVEL---VQLK-NETNRSFALKVLKKRHIVDTSQQGHILSERQIMMEAHS PFIVRLYR--------TFRDPKYLYMLLEACLGGELWTLLRDRGSFDDSTTRFYTGCVIE ALAFLHSGGIIYRDLKPENIILDNRGYAKLVDFGFAKKVGLGKKTWTFCGTPEYVAPEII LNKGHDSSADCWSLGILIFELLSGSPPFSGSDPMMTYNIILRGIDMIEFP-KKITKSAAT LIKRLC-RDNPSERLGNQKNGVKDIQKHKWFEGFNWEGLRQGSIDPPYTPTVDGPLDNSN FDYFPEDTDS-PPD------EESGWDLEF >G_gorilla_ENSGGOP00000003850 MS------IEIP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGLTELLQGF--------------TVEVLRHQPADLLEFAL QHFTRLQQ----ENERKGTARFGHEGRTWGDVGA-AA------GGGTPSKGVNFAEEPMH ------------SDSEDG---EEEEAAPA---------DAGAFN---------------- ---------APVINRF-TRR-AS--VCAEAYNPDEE-EDD----AESR------------ -------------------IIHPKTDDQRNRLQEACKDILLFKNL-DPEQ-MSQVLDAMF EKLVK----DGEHVIDQG--DDGDNFY--VI-DR--GTFDIYV-KC--DGVGRCVGNYDN RGSFGELALMYNTPRAATI--T-------------------------------ATSP-GA LWGLXXXXXXXXXX--XXXXXXXXXXXXXXXX-XXXX-XXXXFSERLKVVDVIGTKVYND GEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVE-ENGAVEIARCSRGQYF-G-ELALV T--NKPRAASAHA--IGT-VKCL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000014212 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------LQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ G--EDVRTANVIA--AEA-VTCLVIDRDSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAK---------------------YEAEA-AFFANLKLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC--DNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN FDSFPEDNDEPPPD------DNSGWDIDF >H_sapiens_ENSP00000363092 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------LQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ G--EDVRTANVIA--AEA-VTCLVIDRDSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAK---------------------YEAEA-AFFANLKLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN FDSFPEDNDEPPPD------DNSGWDIDF >P_troglodytes_ENSPTRP00000004326 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------LQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ G--EDVRTANVIA--AEA-VTCLVIDRDSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAK---------------------YEAEA-AFFANLKLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN FDSFPEDNDEPPPD------DNSGWDIDF >T_nigroviridis_ENSTNIP00000011460 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQRLQN-------ELDKYRSVIKPATQ------------------------------- ------------QVHK-----------------------Q--TE---------------- ----------LQEH-QRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-ES--L----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLTN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QGLQEDILSKLADVLEETHYED GEYIIRQGARGDTFFIISKGKVNVTREDSP------NGEPVYLRSLGKGDWF-G-EKALQ G--EDIRTANVIA--AEA-VTCLVIDRDSFKHLIGGLEDVSSKGH--------------- ----E----------DADAKAKRDR------------------YEAEN-AFFFNLNLADF N-----------------------------------------------------II---- -NTLGVGGFGRVEL---VQLK-SDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKITKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSAIDTSN FDSFPEDNEDPPLD------DNSGWDVDF >G_gallus_ENSGALP00000006027 L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDD-------- -LIPKLQN-------KL-VYRSVIRPAAR------------------------------- ------------QAQQ-----------------------QSARS---------------- ----------LQGE-QRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKELIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYES GEYIIRQGARGDTFFIISKGKVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ W--EDVRTANVIA--AEA-VTCLVIDRDSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAK---------------------YEAEA-AFFANLKLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN FDSFPEDNDEPPPD------DNSGWDIDF >D_rerio_ENSDARP00000071397 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSMKLNPLKQVSGSA----------------KSKNNGES SLVPQVLRVRV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EELET HL----------KKKDEDLNAKELQIKHL--------------EEQLAQQKQ-------- -TLSEISDTLRSKCLQLNKLQDALKSQGELG----------------------------- ------------LLPSPLK------------EKVSQGLTGLLRE---------------- ----------TLNR-RKGAK-AG--VSAEPSSRTYD-SSGIPKFYFES------------ -------------------ARVWKEQSVKKLLTDALNKNQYLRRL-EVQQ-VKDMVECMY ERTYQ----QGEYVIKQG--EPGNHLF--VL-AD--GKLDVYQ-HN--K----LLTSIAV WTTFGELAILYNCTRTASV--K-------------------------------AASN-VK TWALDREVFHNIMR--MTAEARHEQYRNFLRS-VSLL-ASLPGDKLTKIVDCLEVEYYNK GDYIIREGEEGNTFYIIANGKIKVTQSTQD------HEEPQIINTLGKGDYF-G-EKALI S--DDVRSANIIAE-EDG-VECLVIDRETFSQTVGTFDELKKYLQ--------------- ----S--YVDSLARDDKKRNAKRSG--SCTPPNTPVSHDMIELKERES-SFASTIPFTCL E-----------------------------------------------------AI---- -ATLGVGGFGRVEL---VKLK-N-ENVTFALKCIKKRHIVDNRQEEHIYSERRILLETNC PFIVKMYR--------TYKDNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTE AFDYLHNNGIIYRDLKPENLMLDTDGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEII LNKGHGLSVDFWSLGILIFELLTGSPPFTGSDQMIIYTFILKGIEKMDFP-KKITKRPGD LIRKLC-RQNPSERLGNLKNGITDIKKHRWFTGFSWSGLKARNLISPLKREVKGPTDHSY FDSYPPE-EEIPPD------EMSGWDTDF >M_musculus_ENSMUSP00000073268 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------LQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPDEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGQVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ G--EDVRTANVIA--AEA-VTCLVIDRDSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAK---------------------YEAEA-AFFANLKLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN FDSFPEDSDEPPPD------DNSGWDIDF >G_aculeatus_ENSGACP00000012095 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQRLQT-------ELDKYRSVIKPATQ------------------------------- ------------VV-K-----------------------Q--ND---------------- ----------LHEQ-QRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-ES--L----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLTN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-HGLQEDILSKLADVLEETHYGD GEYIIRQGARGDTFFIISKGKVNVTREDLP------NIEPVYLRSLGKGDWF-G-EKALQ G--EDIRTANVIA--AEA-VTCLVIDRDSFKHLIGGLEEVSSKGH--------------- ----E----------DADAKAK---------------------YEAEN-AFFFNLNLADF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKITKNAGN LIKKLCSRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIVPNVTSAVDTSN FDSFPEDNEDPPPD------DNSGWDVDF >G_aculeatus_ENSGACP00000013490 L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EELKQ QL----------QKQCMINQELQRQNKDL--------------EQRLQEKER-------- -LLQELNGQYDELGVP-SQSGNVVEPEI-------------------------------- ------------------------------------------------------------ ---------------RKSRA-AV--IASEPLPETLEIR---------------------- -------------------KRVKKVASETSLIVKAIQKNDFLSRL-DDEQ-TAMMVDLLA VSSYK----PNDDVIKEG--TEGDSMY--IV-AA--GELLVTQ-AG--Q----TLRSLTT GDVFGELAILYNCRRTATV--K-------------------------------AKTA-VR LWCMERQTYRTIIT--NKSKKKREQLLGFLKT-SRTL-KELNDVQLSKIIDSMEEVKYQD KDVIVREGAEANAFYIILKGEVLVTKNVNG------HQ--KQIRRMGKGEHF-G-EQALI R--EVLRTATCSA--EGP-VTCLSIDKEVFEETI----PIEH------------------ ----------------LELFDD----------------------PGSTLRFKDLVPVLYQ E-----------------------------------------------------GRYQGD PVTLGVGGFGRVEL---VT-T-VNHEEYYAMKRVSKKHIVAKRQEEHMLFEKKILKATQC NFIVSLHA--------AFKDTRYIYMVMEFCVGGEIWTKLKEVGRFDEPIAMFCTACVVE AYAYLHKKNIMYRDLKPENLMLDIKGYVKLVDFGFSKEMVHGDKTYSFVGTPEYMAPEII KNQGHDFAVDFWSLGVLIYELLVGSPPFSSSEPQKIYAKILDGV--LKYP-PYMSEAARS IISKMC-RPRPGQRLGNTKNGIRDVRNHRWFSSMNWHKLRVGQLDAPTVRLIRKGPCYIN FDRFPLD-QTKAEE------EFSGWDRDF >G_gorilla_ENSGGOP00000007258 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------LQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGTVNVTREDSP------SEDPVFLRTLGKGDWF-G-EKALQ G--EDVRTANVIA--AEA-VTCLVIDRXXXXXXXXXXXXXXXXXX--------------- ----X----------XXXXXXX---------------------XXXXX-XXXXXXXXXXX X-----------------------------------------------------XX---- -XXXXXXXXXXXXX---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVASPTDTSN FDSFPEDNDEPPPD------DNSGWDIDF >A_aegypti_AAEL015314-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PLVNRYASRR-KS--VFAETYDPEAD-DDD----DGAR------------ -------------------AIFPKTDEQRARLCDSVKNILLFRSL-DKEQ-MNEVLDAMF EKKVK----AKDYIIKQG--DDGDNFY--VI-ES--GIYKAYV-GE--D--QKHIHTYDN SGSFGELALLYNMPRAATI--Q-------------------------------AETD-GQ LWAMDRQTFRRILL--KSAFRKRKMYEALLDA-VPML-KTLQSYERMNLADALIPKTFAK GERIIKQG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000007952 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQRLQN-------ELDKYRSVIKPATQ------------------------------- ------------QVHK-----------------------Q--NE---------------- ----------LHEQ-QRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKEAILDNDFMKNL-ELSQ-IQEIVDCMY PVEYG----KDSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EN--L----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLTN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMDFLKS-VPTF-HDLQEDILSKLADVLEETHYAG GEYIIRQGARGDTFFIISKGKVNVTREDLP------NGEPVYLRSLGKGDWF-G-EKALQ G--EDIRTASVIA--AEA-VTCLVIDRDSFKHLIGGLEDVSSKGH--------------- ----D----------DADAKAK---------------------YEAEN-AFFFSLNLADF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKITKNAGN LIKKLC-RDNPCERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPIIPNVTSPVDTSN FDSFPEDNEDPPPD------DNSGWDVDF >T_nigroviridis_ENSTNIP00000006171 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QLKIEELRQRDTLIDEL--------------ELELDQKDE-------- -LIQRLQN-------ELDKYRSVLRPATA-------QQ---------------------- -----------VQAQQ-----------------------QSLVL---------------- ----------QPDQ-HRSKR-QA--ISAEPTAC--D-ISDLSHVTL-------------- -------------------PFYPKSPESKDMIREAILDNDFMKNL-ELSQ-IHEIVDCMY PVEYG----KDACIIEEG--DVGSLVY--VM-EE--GKVEVTK-EG--M----KLCTMGP GKVFGELAILYNCTRTATV--R-------------------------------TLVP-VK LWAIDRQCFQTIMM--RTGLIKHAEYMDFLKS-VPTF-KGLPEETLSKLADVMEETHYED GDYIIRQGARGDTFFIISNGKVNVTQEDSS------NQEPVHLRELTRGDWF-G-ERALQ G--EDVRTANVIA--ADA-VTCLVIDRDSFKHLIGGLEEVSNRGY--------------- ----E----------DLEAKAK---------------------YEAEN-AFFSSLKLNDF N-----------------------------------------------------IV---- -DTLGVGGFGRVEL---VQLK-KEEAKTFAMKILKKRHIVDTRQQEHIRSEKQIMSEAHC DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTGCVVE AFAYLHAKGIIYRDLKPENLILDSYGYAKLVDFGFAKKISICKKTWTFCGTPEYVAPEII LNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMVEFP-KKVTKNASN LIKKLC-RDNPSERLGNQKNGVKDIQKHKWFEGFNWEGLRKGTLTPPITPDVSSPTDTSN FDSFPEDTDEPPPD------DNSGWDYDF >A_aegypti_AAEL007826-PA MSSPKPAMAGGSK----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------NGTSSHSGGRNNGKLQSDSGNGRSIEDTVL----------------- -------------------------------SLRRELREVYETLREKNEQLVQLEKDVRD RDIS---------IRYLKNEFKKLKDYYSCSKSDLSIPPSFNLNGNGKSAGDGG------ ---------SL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EDL-- -L----------QKVQKECKEKDLQIRELNQKVIRLSNNLIYVQKESLSKDD-------- -RIDELQN-------EIDKFRQVVRPITKAMIEKRCSE---------------------- -----------ETYDSFS----------------PGIENTRVLP---------------- ----------VNHE-PRMKR-QA--ISAEPLSS-----LAGMQGDL-------------- -------------------IKIPKSSLSREIIKSAILDNDFMKNL-EMTQ-IREIVDCMY PVQYG----AGSLIIKEG--DVGSIVY--VM-EE--GRVEVSR-EG--K----YLSTLSG AKVLGELAILYHCQRTATI--T-------------------------------AATD-CK LWAVERQCFQTIMM--RTGLIRQAEYSDFLKS-VPIF-KNLPEDTLGKISDVLEECYYQK GDYIIRQGARGDTFFIISKGQVRVTIRQPD------TQEEKFIRTLGKGDFF-G-EKALQ G--DDLRTANIICDSPEG-VTCLVIDRDTFNQLISNLDEIKNRYN--------------- ----D----------DAVSEKK---------------------KIYEE---FRDVRLTDL R-----------------------------------------------------VI---- -ATLGVGGFGRVEL---VQLA-QDKARSFALKQMKKSQIVETRQQQHIMSEKEIMSEANS DFIVKLFK--------TFKDRKYLYMLMESCLGGELWTILRDRGHFDDGTTRFYTACVVE AFDYLHSRNIIYRDLKPENLLLDVSGYVKLVDFGFAKKLQSGRKTWTFCGTPEYVAPEVI LNRGHDISADYWSLGVLMFELLTGTPPFTGADPMRTYNIILKGIDAIEFP-RNITRNASV LIKKLC-RDNPTERLGYQRGGISEIQKHKWFDGFYWEGLRNRSLPPPILPKVQSVVDTAN FDDYPADPDGPPPD------DLSGWDEDF >D_rerio_ENSDARP00000090593 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QV-------------------------QTRSE---------------- ----------LPEH-QRTKR-QA--ISAEPA----N-IQQLSHVTL-------------- -------------------PNVPKSAKSKDLIKSAILDNDFMKNL-EMSQ-IQEIVDCMY PVDYD----KNSCIIKEG--DVGSLVY--VM-ED--GKVEVTK-EG--L----KLCTMGP GKVFGELAILYNCTRTATV--R-------------------------------TVSS-VK LWAIDRQCFQTIMM--RTGLIKHAEYMELLKS-VLTF-RGLPEEILSKLADVLEETHYED GNYIIRQGARGDTFFIISKGKVTMTREDCP------GQEPVYLRSMGRGDSF-G-EKALQ G--EDIRTANVIA--AET-VTCLVIDRDSYKHLIGGLEDVSNKGC--------------- ----E----------DAEAKAK---------------------YEAEN-AFFSNLNLSDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-SDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHS DFIVRLYR--------TFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKITKNAAN LIKKLC-RDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNVTSSTDTSN FDSFPEDNEDPPPD------DNSGWDIDF >T_rubripes_ENSTRUP00000002807 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QLKIEELRQRDTLIDEL--------------ELELDQKDE-------- -LIQRLQN-------ELDKYRSVLRPATA-------QQ---------------------- -----------VQAQQ-----------------------QSLVL---------------- ----------QPDQ-HRSKR-QA--ISAEPTAC--D-ISDLSHVTL-------------- -------------------PFYPKSPQSKEMIREAILDNDFMKNL-ELSQ-IHEIVDCMY PVEYG----KDACIIEEG--DVGSLVY--VM-EE--GKVEVTK-EG--M----KLCTMGP GKVFGELAILYNCTRTATV--R-------------------------------TLVH-VK LWAIDRQCYQTIMM--RTGLIKHAEYMDFLKS-VPTF-KGLPEETLSKLADVMEETHYED GDYIIRQGARGDTFFIISNGKVNVTQEDPD------NQGPVHLRELTRGDWF-G-ERALQ G--EDVRTANVMA--ADA-VTCLVIDRDSFKHLIGGLEEVSNRGY--------------- ----E----------DVEAKAK---------------------YEAEN-AFFSGLKLNDF N-----------------------------------------------------IV---- -DTLGVGGFGRVEL---VQLK-KEEAKTFAMKILKKRYIVDTRQQEHIRSEKQIMSEAHC DFIVRLYR--------TFKDRKYLYMLLEACLGGELWTLLRDRGSFDDTTTRFYTGCVVE AFAYLHAKGIIYRDLKPENLLLDSHGYAKLVDFGFAKKIGLCKKTWTFCGTPEYVAPEII LNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMVEFP-KKVTKNATN LIKKLC-RDNPSERLGNQKSGVKDIQKHKWFEGFNWEGLRKGTLTPPIRPDVSSPTDTSN FDSFPEDTDEPPPD------DNSGWDYDF >C_intestinalis_ENSCINP00000007393 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------C------ ---------SL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RELQF AF----------RRSLSEIKEKEEVIKAL--------------EADLGEKIS-------- -IIQCLHC-------QLDKYRSIVRSRKE------------------------------- ------------QTPK----------------------ITSPMH---------------- ----------DPGQ-KRLKR-NA--ISAEPSSL--N-AVGQADFDKSH------------ -------------------RLVPKLPQTKTLIRQAILENDFMKHL-EDCQ-IEEIVDCMY PVEYS----NGSCIIKEG--DVGSLVY--VL-EGGYGKVAVTK-AG--A----HLCNMGE GKVFGELAILYNCTRTATV--KGKQQLVRAISTDYRISRLKTPIVEETGGLNAPTTN-VR LWAIDRHCFQAIMM--RTGLLKHTEYLEFLTS-VPTF-SKLDEDLLRRIVDVMEECHFEY GDYIIRQGAIGDTFYIISKGNVQVTKRKSA------SSEPVVIRKLAKGDWF-G-ERALQ G--EDMRTANVVVDDTEG-VTCLVIDRQSFTQLIGDLDSVKQKKY--------------- ----D----------EVPVQKY---------------------VSSKSDGFYVGLTLEDF T-----------------------------------------------------AI---- -DTLGVGGFGRVEL---VELK-NDITKTYAMKVLKKRHIVDTRQQEHIKNEKAIMMECQS DFIVKMYR--------TFRDTKYIYMLLECCLGGELWTVLRDKGHFDDSAARFYTGCVVE AFTYMHSRGIIYRDLKPENLLLDTRGYAKLVDFGFAKRIGFSRKTWTFCGTPEYVAPEII LNKGHDLSADYWSLGILMYELMTGSPPFSGSDPMKTYNQILKGIDMIEFP-KKISKNAQS LIRKLC-RDNPSERLGNQRNGIKDIQKHKWFDGFHWVGLRKGSMSPPIKPQVSSSSDSSN FDKFPEDEEEPPPD------DLSGWDVDF >T_guttata_ENSTGUP00000002960 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNRLVKPKHLRQPNRHM--------------ANLAIG---- ---SDVLCSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LELEK EL----------KRKDQQLQESQHHVAEL--------------QEQLAMQTK-------- -VIAELSNELQSKCIQLNKLQDVISTQGEHS----------------------------- ------------LQPSPFK-V--------------------------------------- ----------SADR-RRGAK-EG--VSAEPTTALCD-LSRQTMFSLEK------------ -------------------ATVQKDSSEKKLITDALNRNQFLKRL-EPHQ-TRDMVECMY ERTFQ----QGSYVIRQG--EPGNHIF--VL-KE--GSLEVFQ-QN--K----LLSSIPV WTAFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--VTAQTRQEQYRKFLRS-VSLL-KNLPEDKLTKIMDCLEVEYYDK GDYVIREGEEGNTFFIIAKGKVIVTQSTTD------HSQPQVIKNLHKGDYF-G-EKALI S--DDTRSANVIAD-EYN-VECLVIDRETFNQTVGTYEELQTYLE--------------- ----G--YVANLAQADEKRHAKGRS--FCGQLTKEVSLEMIELKEKVA-QF-PPSPFQNL E-----------------------------------------------------VV---- -TTLGVGGFGRVEL---VKVK-N-ENMAFAMKCIKKKHVVDTKQQEHIYSEKKILEQICS PFVVKLYR--------TFKDNKYVYMLLEACLGGELWSLLRDRGSFDEFTTKFCVGCVTE AFDYLHQIGIIYRDLKPENLILDAEGYIKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LSKGHDFSVDFWSLGILVYELLTGSPPFSGADQMMTYNLILKGIEKLDFP-KVITRRPED LIRRLC-RQNPTERLGNLRNGINDIKKHRWLSGFNWDSLKVRKLTSPLKRELSGPTDYSY FDSYPPE-VGSPPD------ELSGWDKDF >O_latipes_ENSORLP00000000450 P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------SL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQL AL----------QLKVEELRQRDALIDEL--------------ELELDSKDD-------- -LIRQLQV-------ELDRYRSTARRGGQ------------------------------- -----------DVAYA-------------------QKKAYATLY---------------- ----------AIET-RRTKR-HA--FSAEAPPL--D-SAQLAAVSI-------------- -------------------TSYRKSKESRDLIQKALLDNDYMKHL-EREQ-IASIVDSMY PTSLD----KGSCVTQEG--DVGSTLY--VL-EE--GRVEVTK-QG--R----KRSNISG GKVFGELAVLQRCACTATV--T-------------------------------ALTN-VR LWAMDRQGFQTVTM--RAGLLRRSRHTDLLRR-VPWF-QSLPDGVLCRLAEALEETVYSD GDFIIRQGAPGDTFFIVSEGQVKASQQASA------DGERETEWTLSEGDWF-G-EHALK G--EDVRAASVMA--VGG-ATCLVIDRESFKRVVGGPDGGPDGAP--------------- ----DGGDVGSDGGAEVEFRQR---------------------VES---DFISGLSLGHF R-----------------------------------------------------II---- -STLGRGGCSRVDL---VQLE-KYPNRSFALKVLQRSRILQTGQQNRVRSERRILMEAHN PFIVRLYR--------TFRDSRRLYMLLEACLGGDLWSLLQDRGPFDDGATRFYAGCVTE ALVYLHHKGIIYRNLKPETILLDLRGYAKLVDFGFAKYVGVGKKTWTFCGTPEYVAPEIL LNKGHDGSVDCWALGVLLFELLCGSPPFLASDPLDIYNIILRGIDMIQFP-RKITKSAAN LIKGLC-RDRPSERLGNQKNGLRDVQKHKWFDGFDWDGLQQGSIRPPFAPPADGPLVHSD FDSFTEDTDEPPPD------DGSGWDAEF >D_rerio_ENSDARP00000085704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TKKLINEALMKNDFLKKL-EPQH-TREMVDCMY EKIYG----AEQLVIQEG--EPGNFLY--VL-AE--GLLEVIQ-NG--K----FLGQMRP GTAFGELAILYNCKRTATV--K-------------------------------AVSQ-SH IWALDRQTFQTIMM--RSTQARHEEYFSFLRS-VSLL-KDLPEEKLAKIIDCLEIDYFDK GEYIIREGEEGNTFFIIAKGEVSVTQTTEG------FTEPQEIKTLRVGDYF-G-EKALI S--EDVRSANIIAK-END-TQCLVVDRDNFNEMVGTYEELQER----------------- ---------------------------------SPEAAELRRLKEKAT-ALSSTSFLKEL Q-----------------------------------------------------VV---- -ATLGMGGFGRVEL---VKLK-DSEDTAFALKCIKKKHIVDTRQQEHIYSEKIILQQTNS NFIVRLFR--------TFRDDKFVYMLLEVCLGGELWSLLRDMSCFDEPTARFCTGCVLE AFDYLHGKGIVYRDLKPENLLLDAEGYVKMADFGFAKKIGLGKKTWTFCGTPEYVAPEVI MNKGHDFGADCWSLGILIFELLIGSPPFTGSDPIRIYTMVLHGIEKVDIP-KRISKRPED LIRRLC-KLNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLMSPLRRELKGPLDHSY FDMFPPE-LEEPPD------EFSGWDKDF >D_melanogaster_FBpp0088350 MRFCFDRLCFATKRPAQNSNSNAPHSSTTVDAPPRPADVDVATVPVATPAPPPQQPVSNL FYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIEPVEEQRQIHTQIQSPAEIQ IQIPPTPPAPSIQIQIQQRYRRHSSAEDRNLNTRRNDSNITEALRKAASMQQEPNANYQF PTDLGLVSIVNNNNNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGLIGLEHTASGL RLIPAPPTHSDVLTHTLIYGTPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQAQTQG LYTSQGSPVLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSGT GGSATPSPVGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VDPNF IVSNYVAASPQEERFIQIIQAKELKIQEM--------------QRALQFKDN-------- -EIAELKS-------HLDKFQSVFPFSRG--SAAGCAG---------------------- -----------TGGASGSG-------AGGSGGSGPGTATGATRK---------------- ----------SGQNFQRQRA-LG--ISAEPQSE--S-SLLLEHVSF-------------- -------------------PKYDKDERSRELIKAAILDNDFMKNL-DLTQ-IREIVDCMY PVKYP----AKNLIIKEG--DVGSIVY--VM-ED--GRVEVSR-EG--K----YLSTLSG AKVLGELAILYNCQRTATI--T-------------------------------AITE-CN LWAIERQCFQTIMM--RTGLIRQAEYSDFLKS-VPIF-KDLAEDTLIKISDVLEETHYQR GDYIVRQGARGDTFFIISKGKVRVTIKQQD------TQEEKFIRMLGKGDFF-G-EKALQ G--DDLRTANIICESADG-VSCLVIDRETFNQLISNLDEIKHRYD--------------- ----D----------EGAMERR---------------------KINEE---FRDINLTDL R-----------------------------------------------------VI---- -ATLGVGGFGRVEL---VQTN-GDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANC QFIVKLFK--------TFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVE AFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVI LNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFP-RNITRNASN LIKKLC-RDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTN FDDYPPDPEGPPPD------DVTGWDKDF >G_gallus_ENSGALP00000017721 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNASMKHKHLRQPDRHV--------------ANLALG---- -----CASHRV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LELEK EL----------KRKDEELQEGQSLVAEL--------------QEQLSVQTK-------- -VIAELTKELQSKCIQLNKLQDVINTQGEHS----------------------------- ------------LQPSPFR-V---------------TPKNQI------------------ ----------SADR-RKGAK-EG--VSAEPTTQLYD-SSKQARFSFEK------------ -------------------SRVRKDSSEKKLITDALNKNQFLKRL-EPQQ-IREMVECMY ERTFQ----QGSYVIRQG--EPGNHIF--VL-KE--GRLEVFQ-QN--K----LLSSIPV WTAFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--VTAQTRQEQYRNFLRS-VSLL-KNLPEDKLTKIMDCLEVEYYNK GDYVIREGEEGNTFFIIAKGKVKVTQSTAD------HSQPQLIKNLHKGDYF-G-EKALI S--DDVRSANVIAD-EYD-VECLVIDRDTFNQTVGTYEELQTYLE--------------- ----G--YVANLARADEKRHAKRRS--FCGQSTKEVSLEMIQLKEKVA-QF-PSSPFQNL E-----------------------------------------------------VV---- -TTLGVGGFGRVEL---VKVK-N-ENVAFAMKCIKKKHVVDTKQQEHIYSEKKILEQICS PFIVKLYR--------TFKDSKYVYMLLEACLGGELWSLLRDRGCFDEPTTKFCVGCVTE ALDYLHHIGIVYRDLKPENLILDAEGYIKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LSKGHDFSVDFWSLGILVYELLTGSPPFSGADQMTTYNLILKGIEKLDFP-RTITRRPED LIRRLC-RQNPTERLGNLRNGINDIKKHRWLNGFNWDGLKLRKLASPLKRELSGPTDYSY FDSYPPE-EGMPPD------ELSGWDKDF >A_carolinensis_ENSACAP00000010068 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKHKYLKRQEGHA--------------GNCP-P---- ---RYILRSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------WELER EL----------KRQEEELHERNYHILEL--------------QDQLAKQTR-------- -TIADLTEELKCKCIQLNKLQDVVDTQGTNP----------------------------- ------------FLFSPLKEVP--------------KVSPVP------------------ ----------CSNR-RKGAK-EG--VSAEPTSRTYD-LTEQPRFSFEK------------ -------------------ARVRKASSEKKLITEALSRNQFLKRL-DPQQ-IRDMVECMY GRTYQ----QGSYIIKQG--EPGNHIF--VL-AE--GKVEVFQ-QN--K----LLSSIPV WTAFGELAILYNCTRTASV--K-------------------------------AVTI-VK TWALDREVFQNIMR--RTAQARHDQYRNFLRS-VSLL-KNLPEDKLSKIVDCLEVEYYDK GDYIIREGEEGNTFFVIAKGKVKVTQTTDG------QPQTQLIKTLQKGDYF-G-ERALI S--DDVRSANIIAD-END-VECLVVDRETFNQTVGTFEELQAYLA--------------- ----G--YVATLARDDEKRNAQVSS--L-ERLPSDVSLEMIQLKEKVA-QFPSSCPFQNL E-----------------------------------------------------IV---- -ATLGVGGFGRVEL---VKLK-N-ESIAFAMKCIKKKHIVDTKQQEHIHSEKRILEEACS PFIVRLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDETTTKFCVGCVTE AIEYLHCISVIYRDLKPENLILDAHGYIKLVDFGFAKKIAIGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGADQMTTYNLILKGVERLDFP-RIVSKRPED LIRRLC-RQNPTERLGNLKNGIHDIKRHRWLNGFNWEGLKARKLSSPLKRELSGPMDYSY FDRYPPD-QGIPPD------ELSGWDKDF >T_rubripes_ENSTRUP00000032043 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EELKQ QL----------EKQCLINKELQRQNKDL--------------EKRLQEKEK-------- -LLQNLQSQYHDLVFQISLLSPLMRLTP-------------------------------- ------------------------------------------------------------ ---------------RSGRA-VR--LSSPPSPSTRRWRLLAPGS---------------- -------------------RKIPALTSEANLIVKAIQKNDFLSRL-DDEQ-TAMMVELLA VSSFK----PGDHVIKEG--TEGDSMY--IV-AG--GELRVTQ-AG--R----DLRTLTT GDVFGELAILYNCKRTATV--T-------------------------------AKTA-VR LWCMERQTYRTIIT--NKSKKRREQLMGFLKM-SRTL-KDLNDVQLSKIIDSMEEVKYQD KDVIVREGAEANTFYIILKGEVLVTKNVNG------HQ--KQIRRMGKGEHF-G-EQALI R--EVLRTATCSA--DGP-VTCLSIDKERA--------HISF------------------ ----------------CLFAPSSKVLQEAQAPPKS----------SKEIVFEETIPVEHL E-----------------------------------------------------VF---- -DELGVGGFGRVELHSKMT-T-VNHGMYYAMKRVSKKHIVAKRQEEHMLFEKKVLKAIQC DFIVRLHA--------TFKDTCYVYMIMEFCGGGEIWTKLKEVGRFDEPTAVFCTACVVE AFAYLHKKSVMYRDLKPENLMLDVKGYVKLVDFGFAKEMVRGEKTYSFVGTPEYMAPEII KNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIYAKILDGV--LKYP-PYLSEASKS IISKLC-RPRPGQRLGNTKNGIKDVRHHRWFSSINWHKLRMSQLDAPTVRLIRKGPCYIN FDRFPVD-HTKAEE------DFSGWDREF >T_rubripes_ENSTRUP00000001539 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNASMKSKRYKNADGSVTASNSWSHRDGRRLKNAS------ ---LESLRVRV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EELER EG----------KRRNEELQAKEQQIRSL--------------QEQLARQTR-------- -VLAELSEELQTKCIQLSKLQDVMKSQGGAG----------------------------- ------------TASRPTS--------VRKAGKSSPNLSVRIKE---------------- ----------TLNR-RKGAK-AG--VSAEPTS------SSLPKFCFEK------------ -------------------ARVAKDNSVKKLLTDALNKNQYLRRL-ELQQ-IKDIVECMY ERTYQ----RGEYVVKQG--EPGNHLF--VLAAD--GTLDVFQ-HN--K----LLTSITV WTTFGELAILYNCTRTASV--R-------------------------------AVND-VR TWALDREVFQNIMR--RTAEMRHEQYRNFLRS-VSLL-ANLPEDKLSKMVDCLEVEYYDK GEFIIREGEEGSTFYIIAQGKVKVTQTTEA------HTFPQVINTLQKGDYF-G-EKALV S--DDVRSASILAE-ENG-VECLVIDRETFDQTVGTFSELQKHLQ--------------- ----G--YVATLDRDDRKRHARKKS--VSRHQSQPLSSDAICLKEMVS-TFSASRPFDHL E-----------------------------------------------------VV---- -ATLGVGGFGRVEL---VKMQ-D-KDVAFALKIIKKKHVVDNRQEEHIHSERKILAEARS PFIVKLYR--------TFKDNKYVYMLLEACLGGEVWSLLRDRGNFEEPTAKFCVGCVTE AFDYLHRKGILYRDLKPENLLLDAEGYIKLVDFGFAKKIRCGQKTWTFCGTPEYVAPEII LNKGHNFSVDFWSLGILVFELLTGSPPFSGSDQMMTYTFILKGIEKMDFP-KKITKRPED LIRKLC-RQNPAERLGNLKNGITDIKKHRWFNGFSWEGLKAKTLPSPLKRALTGPTDHSY FDSYPPD-EDSPPD------ELSGWDVDF >O_latipes_ENSORLP00000021688 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LIIKAIQKNDFLSRL-DEEQ-IAMMVDLLR ASNFK----PGEEVIIEG--CEGDSMY--IV-AA--GELIVTQ-AG--Q----DLRTLSI GDVFGELAILYNCKRTATV--K-------------------------------AKTQ-VR LWCMERQTYRTIIT--NKSKKRRGQLMGFLKT-SRTL-KNLNDVQLSKIIDSMEEVKYQD KEVIVREGAEANSFYIILKGEVLVTKNVNG------YQ--KQIRRMGKGEHF-G-EQALI R--EVLRTATCTA--DGP-VTCLSIDKDSFCVLL-------------------------- ----------------LLTPADSKVMQEAETPAKS--------LPSSTLRFKDLVPVLYQ E-----------------------------------------------------GRFQGD PVTLGVGGFGRVEL---VNLA-FHHGKYYAMKRVSKKQIVAKRQEEHMLFEKKILKAIQC DFIVRLYS--------TFKDTRYIYMVMDFCSGGEIWTKLKEVGRFDEPIAVFCTACVVE AYAYLHKKNIMYRDLKPENLMLDQRGYIKLVDFGFAKELMRGDKTYSFVGTPEYMAPEII KNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIYAKILDGE--LKYP-PYMNEAAKS IISKLC-RPRPGQRLGNTKNGIKEVRHHRWFGNMNWHKLRLGQLEAPTVRLIRKGPCYIN FDRFPVD-HTKADE------DFSGWDRDF >A_aegypti_AAEL005754-PA MATIKNENIQISDN----------------GGPKTNTTPASVTKGMMVTSPSVATAAALI HPLAPLATVPLEVRDETSQNEKSVHSQPSQTSKRQPGLRAWFRKSNTCGSLYVKCSCSNG VPSGGSPQAGSEAVKGTEEGSQRHSHHH----------NTRPISTSEKDFRKIKVL---H AFAHPDTTTVFTDQN---KYANNLSESPTRALITSAQS--GEFEIVHSTHSKRLSTPNFK ADYAFHPEFVLKKLIPKSNGLSQDGKTPSISIPSPRRPVLK----------KSSRSYPGL SPSGSSVDSIERSLVHNHSASSSVDEVTEEEEQGTRRSSEEFTSSQDSYISFSANTELQR DSFSNTNIQKLSLKYAAIKAVSDHEVQEESLTKQQEEIQLEDNSSIQDTVIQCCS----- ------DSACDS-----DNSSNTCNSSDSSPKSPPSVLQHFSRVLSSPTPGSPITSPQTP T-LDRSAQEFFIQSGILGPMGNGSSVLGRKTSKIVPNVDGPVKERCEDACGLTVSCLVLL LAAAHKIRKNSKLLFGKRTIPLSNGDRRKSIPPEHNCDSFQSYGSTPTLGSGTKSKTLED EI----------HFLRQQLKARDEEISKL--------------KREIDKLKS-------- -VLQQTTTS------SLDRSQNAGSGAGGT-VAPMSSP--KVLQAVEGDLLSSIQANYVM AGQQLPMSELYGITGKGFKLAHSSQLAGIGANDGSFRQNK-------------------- -----------GATLMAMKK-QG--VSGESCEL--T-GSPS-DIKI-------------- -------------------PKYEKDYSAKQLIKDAILENDFFKNI-DSLQ-IREIVDSMY SREFR----SGEYVIHEG--QAGSHLY--VS-AA--GEFEVLK-DG--K----FLGLMGP GKAFGELAILYNCTRTASI--R-------------------------------VLSD-SR VWVLDRRVFQQIMM--RTGLQRIEENVNFLRS-VPLL-KNLSNDVLTKIADVLEVEFYPA GAYIIRQGAAGDSFFLISQGTVKVTQRLPG------CAVEEEIRILGRGEYF-G-EKALI K--EDKRTANIIAM-SPG-VECLTLDRESFSKHIGDLCELHEKDY--------------- ----G----------DEQRVLAFRNLENNNLPSS---------LDAVK-PELMDVELMDL N-----------------------------------------------------VV---- -GTLGVGGFGRVEL---VKLERNGVVQVFALKCMKKKHIVDTKQQEHVFSERKIMLSCHS PFITRLYR--------TYRDDKFVYMLLEACLGGEVWTILRDRSYFEDSTAKFIVGCVLK AFEFLHARGIVYRDLKPENLLLDSRGYVKLVDFGFAKFIGYSSKTWTFCGTPEYVAPEIV LNKGHDRSVDYWALGVLIHELLTGIPPFAAADPMKTYNIILKGIDMVNFP-KHMSRAAVS LIKRLC-RDVPTERLGYQRGGIQDIKKHKWFQGFDWEGLANQTLKSPLQPKLKGPLDMSN FDVFPAD-GHIPPD------EVSGWDEGF >O_latipes_ENSORLP00000001301 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKAPRAEENSCLP-----------------SIHADAP HLDSDILRVRI------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TYLET EL----------ARRNQEFQTQELQLRRL------------------------------- ------QKELETKVSQIEKLQDAIHSHQTVG----------------------------- ------------LSPTALC-----HHSCRHFSAINQGRFHKVAV---------------- ----------EVHR-RLRAK-EG--VSAEPPSADNF-LWRYRPSSVSTART--------- -------------------VHKNSDPSTKRLINEAILSNDFLKKL-EPQH-MREMVDCMY EKVYS----EGQLVIQEG--DAGNYLY--VL-AE--GLLEVIQ-NG--K----LLGEMHP GTAFGELAILYNCKRTATV--K-------------------------------AVLQ-SH IWTLERQTFQTIMM--QTTQARHQEYFTFLRS-VSLL-KQLPEEKLGRIVDCLEVEYFEK GEYIIREGEEGNTFFIIAKGQVTVTQSSEG------FTQPQEIKTLGVGDYF-G-ERALI S--EDVRSANIICN-END-TQCLVVDRDNFNQMVGTYEELQTYLK--------------- ----E--YVGELSKSDERRHFLLSLRPHSQQSDSPEAQELSRLRERTA-RIPANQPFQEL E-----------------------------------------------------VI---- -ATLGMGGFGRVEL---VKLK-D-EESTFALKCIKKKHVVDTRQQQHIYSEKKILQQTNS SFIIRLFR--------TFRDNKYIYMLLEVCLGGELWTVLRDMSCFEEQTARFCIGCVLE AFDYLHSMGIIYRDLKPENLLLDADGYVKMADFGFAKQIGIGRKTWTFCGTPEYVAPEVI MNKGHDFGADCWSLGILVFELLTGNPPFSGSDPIKIYTMVLHGIDRVDFP-KRIGKRPDD LIRRLC-KLNPVERIGNKKNGIMDIKKHKWFQGFNWEGLQGRKLPSPLKRELRGPMDHSN FDMFPPN-SEEAPD------ELSGWDKDF >D_rerio_ENSDARP00000092292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------IVKAIGKNDFLRRL-DEEQ-ISMMVDLMK VLDCR----AGDEIIKEG--TEGDSMY--IV-AA--GELKVTQ-AG--R----DLRILSP GDMFGELAILYNCKRTASV--K-------------------------------AISA-VK LWCIERQTYRSIMT--NKSKMKREQLMGFLKT-ARTL-KALNDVQLSKIIDSMEEVRFQD NEVIVREGAEGNTFYIILKGEVLVTKKVNG------QQ--KTIRKMGEGEHF-G-ELALI R--EILRTATCTA--VGV-VICFSIDKDHYTSGVEGLLEIRHTES--------------- ---------------SCQAQVQVHVIYDAKNSAS---------HSQNKLHFK-------- ---------------------------------------------------------IGD PVTLGIGGFGKVEL---VT-T-LEHRKYFAMKRISKQHVVAKKQEAHILLEKKILQAIRC DFIVRLHA--------AFKDSRYVYMIMEFCPGGEIWTKLKEAGRFEEKIAVFITACVVE AYAYLHNKGILYRDLKPENLMLDSKGYVKLVDFGFAKELSRGEKTYSFCGTPEYISPEII QNQGHDIAADFWSLGVLIYELLVGSPPFSSSEPQKIYAKILDGV--LNFP-SYMGEGAKS IISKLC-RLRPGQRLGNTKNGIKDVRHHRWFNSINWHKLRMGQLEAPTVRLIRKGPCYIN FDRFPYD-KTQAEE------EFSGWDCDF >C_intestinalis_ENSCINP00000010398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PKTGTQVAQIKRALNSNVFLKGL-DANQ-VEQLMDCMS LQTVS----AGSEIIAEG--EYGTHMY--VL-DK--GQVKCRSGER--S----HVIDLNP GTVFGELAILYNCKRTAYV--E-------------------------------AKTD-VT IWSIDRQLFQTVVK--KSGQSKRDEYVRLLRT-VDRL-KSLSENKLLRIADCLEQTTFRM GDYIIRQGDSGDTFYVIQEGSVKVTQNKTGFFNKMKSREEDFLCNMEKGEYF-G-ERALL T--EDKRAANVIAD-SDV-VTLLMLDRQAFSSLIGSLAEVGKTPSVPQLPLESEDPSHLD ETDGRLRELAVVPEEDEEHVLS------EGNHLAPKVTIVTRLSGATE-SVLKRTKLEDL KVRLHILLSYTVAQFFIGYSVGQFVLQGCILLFLVRKFIDTAFSAQYAVNRLNAVI---- -RILGQGGFGCVKL---VQVP-GLSNCAFALKAIRQAKIVKTGQQQHVLAEKNIMLAAKS PFIARLYRYTSSAHDTTYKDSSRIYMLMDAYLGGEMYGVLKRMGSLDEIAARFCAGCVLE ALSYLHERGIVYRDLKPENLMLDHRGYVKLVDFGFAKRVRFGFKTWTFCGTPEYFPPEIL SNAGHDFSADYWSYGILIYELLTRTTPFFAGDDMTVYEGILGGIEGVKFS-KRVKRSAEL LIRNLC-KLEPRDRLGYQKGGVNDIRKHRWFHGFDWQGLRTTSIKSPFKVHIKNAVDTNN FEPCLEELADETDDAEVLRDANMVWAESF >D_melanogaster_FBpp0077706 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------AAGMLTDRER EAIV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SNLTK DV----------QALREMVRSRESELVKL--------------HREIHKLKS-------- -VLQQTTN-------NLNVTRNEKAKKKLYSLPEQCGE-----------QESRNQNPHLC SSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVR---------------- ----------PKAMPAAIKK-QG--VSAESCVQS---MQQSYSIPI-------------- -------------------PKYEKDFSDKQQIKDAIMDNDFLKNI-DASQ-VRELVDSMY SKSIA----AGEFVIREG--EVGAHLY--VS-AA--GEFAVMQ-QG--K----VLDKMGA GKAFGELAILYNCTRTASI--R-------------------------------VLSEAAR VWVLDRRVFQQIMM--CTGLQRIENSVNFLRS-VPLL-MNLSEELLAKIADVLELEFYAA GTYIIRQGTAGDSFFLISQGNVRVTQKLTPT-----SPEETELRTLSRGDYF-G-EQALI N--EDKRTANIIAL-SPG-VECLTLDRDSFKRLIGDLCELKEKDY--------------- ----G----------DESRKLAMKQAQESCRDEP---------KEQLQ-QEFPDLKLTDL E-----------------------------------------------------VV---- -STLGIGGFGRVEL---VKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRS PFICRLYR--------TFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQ AFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEII LNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFP-KHISRWAVQ LIKRLC-RDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRY FDRFPCD-LNEPPD------ELSGWDADF >T_nigroviridis_ENSTNIP00000019469 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PETLEITR--------------------- -------------------ARVKKNSSEANLIVKAIQKNDFLSRL-DDEQ-TAMMVDLLA VSNFK----PGSHVIKEG--SEGDSMY--IV-AG--GQLQVTQ-AG--R----DLRTLTT GDVFGELAILYNCKRTATVTDS-------------------------------AKTA-VR LWCMERQTYRTIIT--NKSKKRREQLMGFLKM-SQTL-KDLNNVQLSKIIDSMEEVKYQD KDVIVREGAEANTFYIILKGEVLVTKNVNG------HQ--KQIRRMGKGEHF-G-EQALI R--EVLRTATCTA--DGP-VTCFTIDKEVFEETI----PVEH------------------ ----------------LELFDDSKVLQEARAPAKSSKQFCLSTSPSSTLRFKDLVPVLYQ E-----------------------------------------------------GRYQGD PVTLGVGGFGRVEL---MT-T-VNHGMYYAMKRVSKKHIVAKRQEEHMLFEKKILKAIQC DFIVRLHA--------TFKDTRYVYMIMEFCGGGEIWTKLKEVGRFDEPMAVFCAACVVE AFAYLHKKSIMYRDLKPENLMLDAKGYVKLVDFGFAKEMVRAEKTYSFVGTPEYMAPEII KNQGHDFAVDFWSLGILIFELLAGSPPFSSSEPQKIYAKILDGV--LKYP-PYLSEASKS IISKLC-RPRPGQRLGNTKNGIKDVRHHRWFSSINWHKLRMSQLDAPTVRLIRKGPCYIN FDRFPVD-HTKVEE------EFSGWDQDF >M_domestica_ENSMODP00000025995 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKQSKIPDGHA--------------GKLSGT---- ---IDALRSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------KKKDDELQQREYHLREL--------------QEKLSKQTI-------- -ALAEITEELQNKCIQLNKLQDVVNIQGGNS----------------------------- ------------LLFSPYK-VP---------LQVNRRTSGLV------------------ ----------SLHS-RRGAK-EG--VSAEPTTRTF------AEFSFEK------------ -------------------ARVRKDSSDKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYP----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVFQ-GN--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AISN-VK TWALDREVFQNIMR--RTAQARDEQYRQFLRS-VCLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGVVKVTQSTEG------YDQPQLIKTLKKGDYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFSQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SGWRQTKALSLEMIQLKEKVA-KFSSSSPFQNL E-----------------------------------------------------IV---- -TTLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHIYSEKKILEEMCS PFIVKFYR--------TFKDRKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKIDFP-KKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKRHRWLNGFNWEGLKARSLPSPLKRELSGPIDHSY FDNYPPE-KGIPPD------ELSGWDKDF >X_tropicalis_ENSXETP00000046551 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSMKSKPLKQPDGQR--------------VNFSISSCNK LRNADTVKNKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------WELEI EL----------KKKDEKLKNKEQIFQEL--------------QEQIKKQNQ-------- -VIEEMAEELQNKCVQLNKLQVVVQTQNGISTTPDLHK---------------------- -----------MLQPSPTK-TLHALPTKSLKGSPLKTFSGLFS----------------- ----------NSNK-RKGAK-EG--VSAEPTSR-YD-GGDHPRFSFEK------------ -------------------ARVRKNTSEKILISDALNKNQFMKRM-DHHQ-IQDMVECMY ERIYL----QGEFIIRQG--EPGSQIF--VL-AD--GKAEVFQ-EN--K----LLTSIPV WTTFGELAILYNCTRTASV--K-------------------------------AITG-VR TWALDREVFQNIMR--KTAQSKHEEYLSFLRAIVPLL-KELPEHKLMKIADCLELEFYEM DDYIIREGEEGSTFFIISKGKVKVTQSTEG------YKEPQYIKFLEKGDYF-G-EKALI S--DDVRSANILAY-GDR-VECLVMDRETFNKTVGTYEELMKCLE--------------- ----G--YVANLTLDDERRHAKSPV--NERHL-RAVSMELNKMKQTLA-RFPSASPFENL E-----------------------------------------------------IV---- -TTLGVGGFGRVEL---VKVK-N-ENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACS PFIVKLYC--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTE AFEYLHQKGVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVI LNKGHSFSVDFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFY-KNITKRPED LIRRLC-RENPAERLGNMKNGIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSY FDSYPPD-EEIPPD------EVSGWDQDF >G_aculeatus_ENSGACP00000013540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RSKEMIKDAILDNDFMKNL-ELSQ-IQEVVDCMY PVDYG----KDACIIKEG--DVGSLVY--VM-EE--GKVEVTK-EG--K----KLCTMGP GKVFGELAILYNCTRTATV--M-------------------------------TLMH-VK LWAIDRQCFQTIMM--RTGLIKHAEYMDFLKS-VPTF-QGLPEETLTKLADVMEETHYEE GEFIIRQGARGDTFFIISMGKVNVTQEDSA------NQEPAHLRVLSRGSWF-G-EKALQ GHSEDVRTANVIA--AEA-VSCLVIDRDSFNHLLGGLEDVSVRGH--------------- ----E----------DAEAKAR---------------------YEAEN-TFFSSLKLKDF N-----------------------------------------------------II---- -DTLGVGGFGRVEL---VQLK-NEEAKTFAMKILKKRHIVDTRQQEHIRSEKHIMTEAHS DFVVRLYR--------TFKDTKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTGCVVL AFAYLHAKGIIYRDLKPENLILDSRGYAKLVDFGFAKKIGFCKKTWTFCGTPEYVAPEII LNKGHDVSADYWSLGILMYELLTGSPPFSGPDPMKTYNVILRGIDMIEFP-KKIPKNAAS LIKKLCRRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLKKGTLTPPITPNVSSPTDTGN FDNFPEDADEPPPD------DTSGWDYDF >M_mulatta_ENSMMUP00000026112 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGHS--------------GNLT------ ---TDALRNKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYNLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVVHMQGGSP----------------------------- ------------LQASPDK-VP---------LEVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SNWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELNGPIDHSY FDKYPPE-KGMPPD------ELSGWDKDF >H_sapiens_ENSP00000264399 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGHS--------------GNLT------ ---TDALRNKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYHLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVVHMQGGSP----------------------------- ------------LQASPDK-VP---------LEVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SNWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY FDKYPPE-KGMPPD------ELSGWDKDF >P_troglodytes_ENSPTRP00000027855 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGHS--------------GNLT------ ---TDALRNKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYHLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVVHMQGGSP----------------------------- ------------LQASPDK-VP---------LEVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SNWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSY FDKYPPE-KGMPPD------ELSGWDKDF >E_caballus_ENSECAP00000022043 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGHS--------------GNLT------ ---TDALQSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYHLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVLHMQGGSP----------------------------- ------------LQASPDK-VP---------LEVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GQLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--EDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SNWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKRHRWLNGFNWEGLKARNLPSPLQRELSGPTDHSY FDKYPPE-KGVPPD------ELSGWDKDF >M_musculus_ENSMUSP00000031277 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHAKHPDGHS--------------GNLS------ ---NEALRSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LELER EL----------RRKDAELQEREYHLKEL--------------REQLAKQTV-------- -AIAELTEELQSKCIQLNKLQDVIHVQGGSP----------------------------- ------------LQASPDK-VP---------LDVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYVIKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEEYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFDELQKYLE--------------- ----G--YVATLNRDDEKRHAKRSM--SSWKLSKALSLEMIQLKEKVA-RFSSTSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSY FDKYPPE-KGVPPD------EMSGWDKDF >P_pygmaeus_ENSPPYP00000016617 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGHS--------------GNLT------ ---TDALRNKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYHLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVVHMQGGSL----------------------------- ------------LQASPDK-VP---------LEVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SNWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELNGPIDHSY FDKYPPE-KGMPPD------ELSGWDKDF >R_norvegicus_ENSRNOP00000003237 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKHPDGQS--------------GNLS------ ---NEALRSKV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AELER EV----------KRKDAELQEREYHLKEL--------------REQLAKQTV-------- -AIAELTEELQSKCIQLNKLQDVIHVQGGSP----------------------------- ------------LQASPDK-VP---------LDVHRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTSRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIVKQG--EPGNHIF--VL-AE--GRLEVFQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEEYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--DDVRSANIIAE-END-VACLVIDRETFNQTVGTFDELQKYLE--------------- ----G--YVATLNRDDEKRHAKRSM--SSWKLSKALSLEMIQLKEKVA-RFSSTSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENIAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSY FDKYPPE-KGVPPD------EMSGWDKDF >B_taurus_ENSBTAP00000003877 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GNGSVKPKHSKNPDGHP--------------GNLT------ ---ASALRSRV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TELER EL----------RRKDAEIQEREYHLKEL--------------REQLSKQTV-------- -AIAELTEELQNKCIQLNKLQDVVHLQGGSL----------------------------- ------------PRASPDK-VP---------LEVQRKTSGLV------------------ ----------SLHS-RRGAK-AG--VSAEPTTRTYD-LNKPPEFSFEK------------ -------------------ARVRKDSSEKKLITDALNKNQFLKRL-DPQQ-IKDMVECMY GRNYQ----QGSYIIKQG--EPGNHIF--VL-AE--GRLEVSQ-GE--K----LLSSIPM WTTFGELAILYNCTRTASV--K-------------------------------AITN-VK TWALDREVFQNIMR--RTAQARDEQYRNFLRS-VSLL-KNLPEDKLTKIIDCLEVEYYDK GDYIIREGEEGSTFFILAKGKVKVTQSTEG------HDQPQLIKTLQKGEYF-G-EKALI S--EDVRSANIIAE-END-VACLVIDRETFNQTVGTFEELQKYLE--------------- ----G--YVANLNRDDEKRHAKRSM--SSWKLSKALSLEMIQLKEKVA-RFSSSSPFQNL E-----------------------------------------------------II---- -ATLGVGGFGRVEL---VKVK-N-ENVAFAMKCIRKKHIVDTKQQEHVYSEKKILEELCS PFIVKLYR--------TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE AFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI LNKGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFP-RKITRRPED LIRRLC-RQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARNLPSPLQRELSGPTDHSY FDKYPPE-RGVPPD------ELSGWDKDF >O_cuniculus_ENSOCUP00000009871 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ---------TL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RDLQY AL----------QEKIEELRQRDALIDEL--------------ELELDQKDE-------- -LIQKLQN-------ELDKYRSVIRPATQ------------------------------- ------------QAQK-----------------------QSAST---------------- ----------VQGE-PRTKR-QA--ISAEPTAF--D-IQDLSHVTL-------------- -------------------PFYPKSPQSKDLIKGG---XDFM-NL-ELSQ-IQEIVDCMY PVEYG----KDSCIFKEG--DVGSLVY--VM-ED--GKVEVTK-EG--V----KLCTMGP GKVFGELAILYNCTRTATV--K-------------------------------TLVN-VK LWAIDRQCFQTIMM--RTGLIKHTEYMEFLKS-VPTF-QSLPEEILSKLADVLEETHYEN GEYIIRQGARGDTFFIISKGKVNVTREDSP------SEDPIFLRTLGKGDWF-G-EKALQ X--XXXXXXXXXX--XXX-XXXXXXXXXSFKHLIGGLDDVSNKAY--------------- ----E----------DAEAKAX---------------------XXXXX-XXXXXXXXXXX X-----------------------------------------------------XX---- -XXXXXXXXXXXXX---VQLK-SEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS DFIVRLYR--------TFKDSK-LYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFP-KKIAKNAAN LIKKLC-RDN-SERLG-LKNGVKDIQKHKWFEGFNWEGLRKGTLTLPIIPS--------- ----------------------------- >A_gambiae_AGAP008585-PA METIKRENIQLGDNRKLVATMGGPLPPSAIGATASSSTVVVRSSPTQPTPPQSVAEASVV NPVTSLCEV---VDQRQAPGEKSVHPQSPTSH------RAWFRKSNTCGSLYVQCGCTVE PGDGTQP-----------NDQQRHSDPAWSSSPPRPPVPTRPISLSDKDIRRIRPRTDKP PFIHPDSPTTVYSGAAVPHDASVRKSHPNRALVPTAQTANGDYEILHTAHSKRYSTPTIG TGYAFHPEFVLQKLGPIGD---EAGGAAQIQSPSPQSEPVRGGAAKVVFKQRSCTSYPGL AEGSEPFGA-------SFSNASSVEEVGSAVVRGQ-------DAEIGALPTLGSFEDLER RQSVSSPPLPQQQQHQPAVTVNDTGGTLDT-TGHCRGVLIESNSNSAGKVSSACAIPARK GRQLFVDSGSDQLSVSLDTGREAHRRSEAAHHQPGAVASCISAENSPPSPPSLLLSPVIP SKFDCSAKEYLIQSGILGPMGNGSSLLMRKTSKIVPNIDTPVKERVSASGSL--ACASGL LVNGLLIRKNSVKFWGK----VLTEDRRKSLTGQ--CDSLQSYGSSMTI-SGTEPNSLEE EL----------VGLRRLLRARDDEIDKL--------------RREIDKLKS-------- -VLQQKAIN------SLEQTSIPSGQQRLTLTSPAGTPSHKGQHVAEGELLSSIQANYAM AGQ--PLSELFGISGNSFKLHQMKSVKGI------------------------------- -------------TLQAMKK-QG--VSGESCDL--M-GSQSSDIKI-------------- -------------------PKYKKDFSAKQLIKDAIMENDFFKNI-DSLQ-IREIVDSMY SREFR----KGEYVIHEG--EAGSHLY--VS-AA--GEFEVIK-DS--K----VLGVMGP GRAFGELAILYNCTRTASI--R-------------------------------VLCD-SR VWVLDRRVFQQIMM--RTGMQRIEENVNFLKS-VPLL-KHLSNDVLTKIADVLEVEFYPA GAFIIRQGAAGDTFFLISQGTVKVTQRLPG------RSVEEEIRILVRGEYF-G-EQALI R--EDKRTANIIAM-SPG-VECLTLDRESFTKHIGDLCELQEKNY--------------- ----G----------DEERVLAFRNLENTH--PS---------LGSCQ-PELMDVNLTDL E-----------------------------------------------------VV---- -GTLGVGGFGRVEL---VKLERNGDTKVYALKCMKKRHIVDTRQQEHMYSERKIMLACQS PFICRLYR--------TYKDAKFVYMLLEACMGGEVWTILRDRVTFEDSTAKFIVACVLQ AFDFLHARGIVYRDLKPENLLLDARGYAKLVDFGFSKFIGYSSKTWTFCGTPEYVAPEII LNKGHDRSVDYWALGILIHELLTGIPPFTAADPMKTYNIILKGIDMVNFP-KHMSRAAVS LIKRLC-RDVPSERLGYQRGGVQDIKKHKWFQGFDWDGLIALTLKSPLQPNLLGPLDMSN FDIFPKD-LDIPPD------ELSGWDADF >C_elegans_F55A8.2a.1 MSSGSRPSSGGGGGGGGASGGAGGGAPGGGGGGIR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GFFSKLRKPSDQPNGN------------------QVQVGTR TFEAHELQKLI------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PQLEE AI----------SRKDAQLRQQQTIVEGH--------------IKRISELEG-------- -EVTTLQR-------ECDKLRSVLEQKAQSAASPGGQP---------------------- ------------PSPSPRT-----------DQLGNDLQQKAVLP---------------- ----------ADGV-QRAKK-IA--VSAEPTNF------ENKPATL-------------- -------------------QHYNKTVGAKQMIRDAVQKNDFLKQL-AKEQ-IIELVNCMY EMRAR----AGQWVIQEG--EPGDRLF--VV-AE--GELQVSR-EG--A----LLGKMRA GTVMGELAILYNCTRTASV--Q-------------------------------ALTD-VQ LWVLDRSVFQMITQ--RLGMERHSQLMNFLTK-VSIF-QNLSEDRISKMADVMDQDYYDG GHYIIRQGEKGDAFFVINSGQVKVTQQIEG------ETEPREIRVLNQGDFF-G-ERALL G--EEVRTANIIAQ-APG-VEVLTLDRESFGKLIGDLESLKK-DY--------------- ----G----------DKERLAQ-----VVREPPSPVKI-----VDDFR-EEFAQVTLKNV K-----------------------------------------------------RL---- -ATLGVGGFGRVEL---VCVN-GDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETST DWIVKLYK--------TFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLE GLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEII LNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATA LVKKLC-RDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTN FDNYPPD-NDVPPD------EFSGWDEGF >A_aegypti_AAEL013214-PA M----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------HLIDRLVPGSYIVAHWFDPVRL SRRIYEQEFNPIANGTSRTVGKFSPKGTERESGLGSLDERLNLPNGTPWEARPVSVPQPQ FERKTPLPTVKDRISASSQEPDRNVNFELLKEIQQTKILLQLALESKLREHPNNDDRHQL VKLEKEIKELQNRISKSTIVPEPVQESVIVRQNAHPTARASPQPSHGPPRPNLPPPKSSL SRQISTIPTQAWEASETSDDYDTIPPSK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SKVQS VP----------EVTSSEEEDEDEEIPDT--------------QDDTSQDEEPTPPKLPP PRVPSMVDDMISLSVPLSMVSNEIEKAQQAPPVPSGPP---------------------- -----PKRMPPPTPEKEVTLGTPTQRDSEDSLPPPKIEELNSSR---------------- ----------TAGILKKVRK-EG--VLSDKTEV-----KGSREIVI-------------- -------------------PSHPKRTDDELLIRKAITANEFLNNLMDEER-LKAVTDAMS PMTFP----PNSYIIKEG--DIGAHFF--VS-AD--GTYEVVA-EN--K----VIKSFGR GVVFGELAILYKAKRFASI--R-------------------------------VTTE-AK VWMLERKVFQKIMM--KSGRKEREENVKFLST-VSIL-KDLQTEKLHKISDLLKREFYAT GSTIIQQGDPGDKFYIIRGGSVNVIKT-DR------HGVDKLVGTLQRGAYF-G-EQALL H--EDRRLASIIAN-PPG-TECLTLNRIAFNEFLGGLEQLREIKL--------------- ----S----------DDLPRIS---------------------GDKNTSSEYDHIQLHDL T-----------------------------------------------------YI---- -GTLGIGGFGRVEL---VRYQ---KQKTFALKYLKKIEMVRQQQQEHAYSEKDIMLSCNS PFIVRLYK--------TYRDKKYLYFLMEACLGGDVWTILQKSKHFDERTARFMAGCVVE AFEYLHSRNMIYRDLKPENLMLDEQGYIKLVDFGFAKRIGANQKTWTFAGTPEYVSPEII LNKGHDRAVDYWALGVFIHELLVGKPPFRGKNHMKTYNAILRGIDIIELP-SRIPKKAQV LIKRLC-RQIPAERLGYGKNGIADIKNHPWFSGFEWQRLKERTLPAPLVRPIQSDTDLSN FDEYPKD-QDEPPD------ETSGWDINF