>M_mulatta_ENSMMUP00000001339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPGTEPAAPVSSTS-SLPLAALNMRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY ILKQQQEEAEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000379625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPGAGSAAPVSSTS-SLPLAALNMRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETQADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY ILKQQQEEAEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000003761 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPGAGSAAPVSSTS-SLPLAALNMRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY ILKQQQEEAEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000001633 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPGVGSAPHIPSAS-SLPLAALNVRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETHTDPTGSLLDDWQGR-----PGASVGRLLELL---AKLGRDDVLVELGPSIEEDCQKY ILKQQQQESEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GQM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000025449 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPAAGSAAPISSTS-SLPLAALNMRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY ILKQQQEEAEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000015673 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MRPDRAEAPGQTAMAAGGPGAGSAAPVSSTS-SLPLAALNMRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETHADPTGRLLDAWQGR-----PGASVGRLLELL---TKLGRDDVLLELGPSIEEDCQKY ILKQQQEEAEKPL---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GHM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000007386 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TRRRRCGPRRPAMAAEGSRAGSASPVCPKA-SLPLAALNVRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWTALAEEMGFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RHL EMHADPTGKLLDDWQGR-----PGASVGRLLELL---TKLGRDDVLVELGPSIEEDCQKY ILKQQQEESEKPL---------------------------------------QVPAVDSS DPRTPE------------------------------------------------------ ------------------------------------------------------------ -------RGGITMLDDPS------GQM-------PERFDAFICY--CP---------SD- --IQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSRECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000002088 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAAGGPDLSSEPPARSAS-SLPLAALNVRV RRRLALFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVAADWSALAEEMGFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RQL ETRPDPTGSLLDAWQSR-----PGASVGRLLELL---EALGRDDVLAELRPSIEEDCQKY IWKQQQEESEKPL---------------------------------------QVAVVGSS VPRTPE------------------------------------------------------ ------------------------------------------------------------ -------LAGITTLDDPL------GQV-------PERFDAFICY--CP---------SD- --MQFVQE-MIRQLE-Q---TNYRLKLCVSDRDVLPGACVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKAMKK--------EFPS ILRFI-TVCDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000000735 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MAEGVPRAGSALPAASLS-SLPLAALNVRV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NVRA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PVAADWTVLAEAMDFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------QQL EKYADPTSRLLDDWQRR-----PGASVGRLLELL---AKLGRDDVLMELGPSIEEDCQKY ILKQQQEASEKPL---------------------------------------QVDSIDSS ITRIND------------------------------------------------------ ------------------------------------------------------------ -------MAGITIRDDPL------GQK-------PECFDAFICY--CP---------SD- --IEFVHE-MIRQLE-Q---TNYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDEYL-QSKECDFQTKFALSLSPGAHQKRLIP-IKYKPMKK--------EFPS ILRFI-TVCDYTNPCT----QNWFWTRLAKALSMP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000018341 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSAGGPRVGSVSVDSYLF-SLPLVALNVGV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TAAADWTSLAEEMGFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------REF ETRPDPTRSLLDAWQGR-----SGSSVGRLLELL---ALLDREDILYELKDRIEEDCQKY IRNQQKQESEKPL---------------------------------------QVARVESS VPQTKE------------------------------------------------------ ------------------------------------------------------------ -------LGGITTLDDPL------GQT-------PELFDAFICY--CP---------SD- --IEFVQE-MIRQLE-Q---TDYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGVQQKRLIP-IKYKAMKK--------DFPS ILRFI-TICDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000035092 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MSAGDPRVGSGSLDSFMF-SIPLVALNVGV RRRLSLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PVAADWTLLAEEMGFEYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------REL ETRPDPTRSLLDAWQGR-----SGASVGRLLELL---ALLDREDILKELKSRIEEDCQKY LGKQQNQESEKPL---------------------------------------QVARVESS VPQTKE------------------------------------------------------ ------------------------------------------------------------ -------LGGITTLDDPL------GQT-------PELFDAFICY--CP---------ND- --IEFVQE-MIRQLE-Q---TDYRLKLCVSDRDVLPGTCVWSI-------AS-ELIEKRC RRMVVVVSDDYL-QSKECDFQTKFALSLSPGVQQKRLIP-IKYKAMKK--------DFPS ILRFI-TICDYTNPCT----KSWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000009820 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PLVALNYAL RRRLSLLL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPGA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AVAADWASLAEALGYEFLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RAF EAHADPTAQLLHDWQRRAS---PPATAGALLDAL---RRLHRHDVLADLAPAIEEDCKKY LQRKREEQAERPV---------------------------------------QVPAVDSS FPRMSE------------------------------------------------------ ------------------------------------------------------------ -------LRGITTQDDPM------GQF-------PEMFDAFICY--CQ---------SD- --LPFVQE-MIQELE-H---TDHKVKLCVFDRDVLPGTCVWSI-------TS-ELIERRC RKMVVVISDDYL-ESEECDFQTKFALSLSPGARQKRLIP-VKCKTMKK--------EFPS ILRFI-TLCDYTNPAT----KKWFWMRLAKSLLLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_latipes_ENSORLP00000012280 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MAGCSSDVDLW-TVPLVALNVTV RRKLGLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPKN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TVAADWMTVAEEMGFTYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNY EASKNPTKTVLEDWQARS----KDASVGKLLSIL---TEVERKDVVEDLRPQIDEDVRKY LES-LQRKSEPPL---------------------------------------QVAEVDSC VPRTPE------------------------------------------------------ ------------------------------------------------------------ -------RFGITVEDDPD------GS--------PEMFDAFICY--CQ---------DD- --FHFVCE-MIRELE-Q---TDHKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRC KRMVVVISDEYL-ESDACDFQTKFALSLCPGARNKRLIP-VIYKTMKK--------PFPT ILRFL-TVCDYTKPCT----QAWFWIRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_nigroviridis_ENSTNIP00000015721 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MACCESKTDLF-KIPLVALNMSF RKKLGLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AVAADWMALAEAMGFTYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNY ETSVNPTVMVLEAWQARS----TEATVGKLLSVL---SGVERNDVLEDLQPILDEDVRKY QEK-VQRDAEHPV---------------------------------------QVDEVDSC YPRTLE------------------------------------------------------ ------------------------------------------------------------ -------RVGLTLDDDPE------GT--------PELFDAFICY--CP---------SD- --FEFVHV-MIRELE-Q---TDFKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRC KRMVVVISDEYL-DSEACDFQTKFALSLSPGARNKRLIP-VKYKSMTK--------PFPS ILRFL-TLCDYTRPCT----QTWFWKRLATALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000020711 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MASKLSIDHE-AIPVTALNCSF RKKLGLFL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPTN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TVAADWRTVAELMDFTYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNF EKRECPFEKVLTDWETR-----PDATVANLLSIL---EKAERKDVISELKEILDDDCRKY MER-QQR---KPL---------------------------------------QVPVVDSC GPRTQE------------------------------------------------------ ------------------------------------------------------------ -------REGITLYDDPQ------GLT-------PETFDAFICY--CQ---------SD- --IQFVHE-MIKQLE-H---TEYNLKLCVFDRDVLPGTCVWTI-------AS-ELIEKRC KRMVVVISDDYL-DSDACDFQTKFALSLCPGARTKRLIP-VVYKSMKR--------PFPS ILRFL-TICDYSKPCT----QVWFWTRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000000429 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MATAPSQPAASPGPGPLPDLQ-AVPMVALNYGV RRRLGLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAADWTALAEALGCSFLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RRL ERLPDPTAALLEEWPGRCP---GGATVGQLLAVL---RRLGRHDVLSDLAGSVEEDCKKY LQR-KQEEANQPL---------------------------------------QVPAVDSS VPKTSE------------------------------------------------------ ------------------------------------------------------------ -------LMGITIRDDPY------GSG-------TEIFDAFICY--CQ---------KD- --LQFVQE-MIRELE-Q---TEFKLKLCVFDRDVLPGACVWSI-------SG-ELIERRC RRMVVVVSDDYL-ESDECDFQTKFALSLSPGARHKRLIP-VKYKSMKN--------EFPS ILRFI-TICDYTNPCT----KKWFWTRLAKSLMLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000039929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MACGSSLRSVDMN-SIPLVALNYNV RHRLSLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPNA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VVAAGWTQLAEEMGYDYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNF ERFPDCTMKLLEDWEKKC----FRATVGGLLEML---KKMERNDILTDLGPLIEADCMKH LEK---KNAPLPL---------------------------------------QDDKVDS- ----SE------------------------------------------------------ ------------------------------------------------------------ -------QYRITKSDDPS------GSL-------PETFDAFICY--CA---------QD- --ISFVQE-MISRLE-Q---TDYKLKLCVFDRDVLPGTCLWSI-------TS-ELIEHRC RKMVVIISDDYL-DSSECDFQTKFALSLGPGAREKRLIP-VKYKPMKR--------PFPS ILRFI-TLCDYTNPCT----KGWFWERLAKALSR-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_rubripes_ENSTRUP00000044800 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VSTRHVCAASGDVTSALS-RVPLLALNMGF RKKVGLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AVAADWMALAEALGFTFLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNY ESAINPTVKVLEDWQARS----TDATVGKLLSIL---SEVERNDVLEDLQPMIDEDVRRY CER-LNRNPEPPV---------------------------------------QVNQVDSC FHRTLE------------------------------------------------------ ------------------------------------------------------------ -------RVGLTLHDDPE------GT--------PELFDAFICY--CQ---------RD- --FEFVQE-MIRQLE-E---TDFKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRC KRMVVVISDEYL-DSEACDFQTKFALSLSPGARNKRLIP-VKYKSMSK--------PFPS ILRFL-TLCDYTRPCT----QAWFWKRLAKALSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000009551 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EKLGHDYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RRL EALPDPTAALLEEWQSRCP---GGATVGQLLELL---RQLGRHDVLLELGGSVEEDCKKY LRR-KQQEAEQPL---------------------------------------QVPAVDSS VPKTSE------------------------------------------------------ ------------------------------------------------------------ -------LMGITTRDDPY------GHG-------TEMFDAFICY--CQ---------KD- --LQFVQE-MIRELE-Q---TEFKLKLCVFDRDVLPGTCVWSI-------SG-ELIERRC RRMVVVISDDYL-ESDECDFQTKFALSLSPGARLKRLIP-VKCKTMKN--------EFPS ILRFI-TICDYTNPCT----KMVLDKTGKISLAAVMQSFESFFSICPGCAFGPRCSYSIS LQNVDPRSQRLEPAAGSKEFSVALFHNLEGEIEQLCGCSYLIQRAIASSTW--------- ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000004643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MACVDSEVDLW-VVPLVALNMSV RKKLGLYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NPRN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AVAADWMAVAEEMGFNYLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KNY EGTKSPTESVLEDWQARC----TDATVGKLLSIL---EEVERRDIVEDLRPLMDEDVRKY CEN-QKKNAKPPL---------------------------------------QVPEVDSC VPRPTE------------------------------------------------------ ------------------------------------------------------------ -------RIGITLQDDPE------GA--------PELFDAFICY--CQ---------KD- --FAFVRE-MIRELE-Q---TEYKLKLCVFDRDVLPGSCVWTI-------TS-ELIEKRC KRMVVVISDEYL-DSDACDFQTKFALSLCPGAQSKRLIP-VMYKPMTK--------PFPS ILRFL-TICDYTRPCT----QAWFWVRLAKALSQPHKDQASSCV---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000001873 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------LSDLGPSIEEDCQKF LLK-QQEEAEKPV---------------------------------------QVAAVDSS VPRTAE------------------------------------------------------ ------------------------------------------------------------ -------LSGITTRDDPL------GQL-------PELFDAFICY--CP---------SD- --IQFVHE-MIRQLE-Q---TEFGLKLCVSDRDVLPGTCVWSI-------TS-ELIEKRC RRMVVVISDDYL-QSNECDFQTKFALSLCPGARQKRLIP-VKYKAMKR--------DFPS ILRFI-TVCDYTNPCT----KAWFWPRLAKALALP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000020077 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MSAPLSLQDQE KEFNKLAHEQERARLESGESLHGGCDKLAAELDKKPENEGACGGASCLFPPPSYMQQSHA SADPNPLGEI---------------SAKEDERNNVISYAVGMPRSDFC-STKLRHLRFDS RRQLGLHL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------DPER--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATVQNWKSLADLMGFSNLEI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LNF ENERHRTRCVLEEYEVRQ----PSATIGNLCMML---DAIGRQDVLTDMEPWFARDSNMA VEQSHSSMSSNFDLSPSRLLSSP------------------------TSLPIQQNAVTSS WNFGST------------------------------------------------------ ------------------------------------------------------------ ----------FLAQEKPPIDQGTADIQ-------NKSYDAFLLY--DA---------AD- --SKFIREEFLPKVE-----TDAKIKLFVPDRDLDAGVQAFQS-------QL-EFMLRRC SKLVVILSDEFL-KNPDSQWSLNVGVSLDPGSKGKKIIP-VIYKKITE----------PN LLAGI-NPCNRTRVLE----DSWFWNSVIRSLGGVQDNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL007768-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MVNSTPVEVSLNECVDLS-KVPLGALNYKT YELLSALL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NRKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I FKSEDGYYRDWRGLFQVLKLDNYLV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AEL ENHNNPTKRVLDLWENSL----KGANLKDLQNVL---GLIDRWDVLDDSNKLFYDDAEKF LSKTAKQVSTDQL-------------------------------------------EETS IGADED------------------------------------------------------ ------------------------------------------------------------ ----------IITKDDTR-------QN-------KQFYDAFILF--AD---------AD- --IEFATK-IMERME------ERKLKICIKDRDLLAGITFEHE-------AIIKLISERC RRLVVVISREFL-KSPLNNFFVMYAQALQIEQKKRKIIP-CVYERL----------ELPA NLKFY-FILDYKRSNK----LYNFWDKLEDAIKVRTDSPVTEIKNQS-----------KA IETVSIPKITVEDANESSADKVDRTQTKPEQLTTGTSHSVSQPIKKSLSSWDVSNALNRV L-----TSKSKNASSSTSELPTGAENSDQELKKVKWYSKLGLSSSKSSLDGTGEKSEKKK TKWYKTSKKIATAM----------- >A_gambiae_AGAP005252-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MLDNPVK---PTEVSVKNRIDLA-VVPLEALSSRT RELVAELL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NHKR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I FTSEDGYFRDWRGVFDVIGIPKSFL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PLV STNPNPTRCLLDLWQSETHQCKREPNLAELQCVL---GCIDRWDILDDTSKMFERDAEQF LLREQKRAAQRGR---------------------------------------ETEATESK VSADSD------------------------------------------------------ ------------------------------------------------------------ ----------IITRDDTS-------DH-------KQQYDAFILF--AD---------AD- --IEFASK-MVDKLE------ARGLQLCLRDRDILGGSNFEHE-------VISRLISERC RRVVVIISKAFL-ASPLNDFTVTFAQALQIEQKARKVIP-CVYDRC----------ELPP HLRYT-CRLDYQRSQN----LYNFWDKLAESIRDTPRKVGLEVSGRELPAPQKPPVHSKP VELIGPPQPLPKVVVEQPPLVVKLPRAAEQDSRTGS-------LKKSHSFWDIFSNFGHK KDKLNGSTSQLNLNEMATPLPSPKKVGSSPLALIRRDKKQPSAASASSAPSACPLDLPPV IKPVKSKKKWYKPGSRKLASAV--- >D_melanogaster_FBpp0087679 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MRPRFVCHQQH SVAHS------------------------------HYQPHSHFHHHTHRHPNPPHHHHIY GATDVSYRRYRTAGM----------VVAEGVMDSGSGSGTGTGLGHFN-ETPLSALGIET RTQLSRML---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------NRKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V LRSEEGYQRDWRGISELAKQKGFVD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ENANNPMDLVLISWSQRSP---QTAKVGHLEHFL---GIIDRWDVCDDIQENLAKDTQRF IMKQEQRQTALVE------ACPPPPSDCF------------------ETNNNYSSSNNIT VGQSVQ------------------------------------------------------ ------------------------------------------------------------ ----------ILSDEDQR--CVQMGQP-------LPRYNACVLY--AE---------AD- --IDHATE-IMNNLE-S---ERYNLRLFLRHRDMLMGVPFEHV-------QLSHFMATRC NHLIVVLTEEFL-RSPENTYLVNFTQKIQIENHTRKIIP-ILYKT---------DMHIPQ TLGIY-THIKYAGDSK----LFNFWDKLARSLHDLDAFSIYSTRQVQTPSPVEESAPRVT TPSIRIQINDKDVTDMPNYNSCKVPEAETTIVSVSGDTGSPLPEHKPKKKDRFLRRITHS FGKTARSDGASGKTLRHAHSVSTINVTERERTLSASSSNISTTSESKKSFIKWQPNILKK ALFSRSSSKLQTPG----------- >A_gambiae_AGAP010636-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CP------ -------------------------------------------------LPVGNQSLVEL LSVFLNR----------TQLSSIR---------------------------SIAFDDNAK HSNKVTLDPHLF-SGLQNLQ----------------LLKINNL-TTNAFDNPHLFKHFLH LNNLI--ITSNKCIPGKCSHQLKQL----------E---TFSIEDSEISIIPIELVSNLT HLQSLSFRNN---------------SLKQ-VE--RFAMLSSLTHLNFG-YNQLVSLHNDV FYGLPKLEGLDLSSNKLTRL--SAELFGKNKNLMDFLADNQHSSGL-------------- -----------------------------------VLEDKLFAGLIMLQKVSVSN-CNIT VLPEKLFAGATE--IQIIN-LSNN-K-LRSL----------------------PENL--- -FRNLSNLVELNLQKNKLKSMLPDTL-----------------------LADAAQLQTLN LCHN------------------------KLTTVNKHLLQSL------------------G NLSKLQLSHNLLYLIDVDAFKSQSK----------------------------------- ------------------------------------------------------------ --------------------------------------------------SLTSLKLDH- -------------------------------------------NRLTLHAKN-------- -------NGATFGN---TEINS--SSWVL--------FSTLH-KVRRLDLSYNAIDHLFV PFQN-FMESLHTLILSHNL----ITHIGYAE------------------------LSF-L F-NLEGVNLKSNKIAH-LDFNLTSI---PSHHLFNGP----IQLNDNPFNCDCMSYPLVT YLKAESYSS----KSDMLEGLQCAQPLKLLGLQLQDVQ--LEDLICAI-----------D -ASSG---FCPAECKCYKRAVDQ---CAIVNCTAS--NLTR-VPV--IHSPSI------- ------------------IECNF--IE---------------LHLAQNNIR------YLS NEG-----EGWNSVRWLNVSNNRLIAL-SAESLP---KNLELLDVSGNQLTEIDAVFIQK LKSST-LLNITLS--SNPWKCDC-ANPLLTFAVDNAAR-I---TDYVVLQC-IDGQ---P INSATL------------------------------------------------------ -----------KELCAWLTLF-------RLYIVSAAVAVAFIGCILTIWLYVKYNLEIKV WLFKHNLLQWFAT-EEQI-------DM-------NKRYDAFISY--SH---------KD- --EEFVTKELLPKLE-S---EELNFKICWHVRDFMPGEMIANE-------IT-KAVE-ES RRTIIILSLNYL-ESVWGQIEFSTAYLQSLADKCNRVIP-IIYQDIGD--IEQLDPQLQA YLKTN-TYVRW-----D---DPWFWEKLHYAMPHKRRL-KGVQG----TDNMCMES---- ---------------VDKRNPLKTPTTTTL-------------------PINVVEKDDAN SVGTG---------------------------------------------I--------- --------------SVISSERE--- >A_gambiae_AGAP000999-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MIK------ELS NVG-----EGWNTIRRLNIANNSFTTL-PGDSLP---EQLELLDVSGNQLTEVDAAFIIK LNHTA-LRNISLS--ANPWDCHC-ENPLLAFAVDNAAR-I---TGYSTLQC-SDGQ---P INSATL------------------------------------------------------ -----------NDLCAWPTTL-------KFYI-SAAVSLVLAACLLAIWLYMKYSLEIKV WLFKHNLLQWLVT-EEQI-------DM-------DKRYDAFISY--SH---------KD- --EEFVTDQLLPRLE-S---EELNFKICWHVRDFMPGEMIATQ-------IT-KAVE-DS RRTIIILSLNYL-ESVWGQMEFNTAYLQSLEDKRNRVIP-IIYQDIGD--IDQLDPELRA YLKTN-TYVRW-----D---DPWFWDKLHYAMPHKRRP-KGVQA----TDNMRMAS---- ---------------VDKLNLLKAPAIMTPAS----SETT--------PPVEHAEKGIAH DGPLGCYGD--------------------------------PSKPSTMPPF--------- --------------IISNGMSN--- >M_musculus_ENSMUSP00000045770 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMPPWLLARTLIMA------------------------------------ -------------L-FFSCL----------------TPGSLN-PCIEVVPNITYQCMDQK LSKVP---DDIP-----------------------SSTKNIDLSFNPLKILKSYSFSNFS ELQWLDLSRC---------------EIET-IEDKAWHGLHHLSNLILT-GNPIQSFSPGS FSGLTSLENLVAVETKLASL--ESFPIGQLITLKKLNVAHNFIHS--------------- -----------------------------------CKLPAYFSNLTNLVHVDLSY-NYIQ TITVNDLQFLRENPQVNLS-LDMSLNPIDFI----------------------QDQA--- -FQGI-KLHELTLRGNFNSSNIMKTC-----------------------LQNLAGLHVHR LILG-----EFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDF-SDDIVK-FHCLANVS AMSLAGVSIKYLEDVPKHF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------KWQSLSIIR- ------------------------------------------------------------ -----------CQL---KQFPTLD---LP--------------FLKSLTLTMNKGSISFK K-V--ALPSLSYLDLSRNA----LSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFM-G LEELQHLDFQHSTLKRVTEFSAFLS----------LEKLLYLDISYTNT----------- ------------------------------------------------------------ --------KIDFDGIFLGLTSLN-----TLKMAGN--SFKDNTLSN-VFANTT------- --------------------------------------NLTFLDLSKCQLE------QIS WGV----FDTLHRLQLLNMSHNNLLFLDSSHYNQ-L-YSLSTLDCSFNRIETSKGI-LQH F--PKSLAFFNLT--NNSVACICEHQKFLQWVKEQKQF-L---VN-VEQMTCATPV---E MNTSLV------------------------------------------------------ -----------LDFNNSTCYM-------YKTI-ISVSVVSVIVVSTVAFLIYHFYF---- --HL----ILIAGCKKYS-------RG-------ESIYDAFVIY--SS---------QN- --EDWVRNELVKNLE-E---GVPRFHLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVVSRHFI-QSRWCIFEYEIAQTWQFLSSRSGIIF-IVLEKVEK-SLLRQQVELYR LLSRN-TYLEWEDNPLG---RHIFWRRLKNALLDGKASNPEQTAEEEQ----ETATWT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000014020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMPLLHLAGTLIMA------------------------------------ -------------L-FLSCL----------------RPGSLN-PCIEVLPNITYQCMDQN LSKIP---HDIP-----------------------YSTKNLDLSFNPLKILRSYSFSNFS QLQWLDLSRC---------------EIET-IEDKAWHGLNQLSTLVLT-GNPIKSFSPGS FSGLTNLENLVAVETKMTSL--EGFHIGQLISLKKLNVAHNLIHS--------------- -----------------------------------FKLPEYFSNLTNLEHVDLSY-NYIQ TISVKDLQFLRENPQVNLS-LDLSLNPIDSI----------------------QAQA--- -FQGI-RLHELTLRSNFNSSNVLKMC-----------------------LQNMTGLHVHR LILG-----EFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHF-SDDIYN-LNCLANIS AMSFTGVHIKHIADVPRHF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------KWQSLSIIR- ------------------------------------------------------------ -----------CHL---KPFPKLS---LP--------------FLKSWTLTTNREDISFG Q-L--ALPSLRYLDLSRNA----MSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFM-G LEELEYLDFQHSTLKKVTEFSVFLS----------LEKLLYLDISYTNT----------- ------------------------------------------------------------ --------KIDFDGIFLGLISLN-----TLKMAGN--SFKDNTLSN-VFTNTT------- --------------------------------------NLTFLDLSKCQLE------QIS RGV----FDTLYRLQLLNMSHNNLLFLDPSHYKQ-L-YSLRTLDCSFNRIETSKGI-LQH F--PKSLAVFNLT--NNSVACICEYQNFLQWVKDQKMF-L---VN-VEQMKCASPI---D MKASLV------------------------------------------------------ -----------LDFTNSTCYI-------YKTI-ISVSVVSVLVVATVAFLIYHFYF---- --HL----ILIAGCKKYS-------RG-------ESIYDAFVIY--SS---------QN- --EDWVRNELVKNLE-E---GVPRFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVVSRHFI-QSRWCIFEYEIAQTWQFLSSRSGIIF-IVLEKVEK-SLLRQQVELYR LLSRN-TYLEWEDNALG---RHIFWRRLKKALLDGKALNPDETSEEEQ----EATTLT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000024473 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVPW--MVMALIMA------------------------------------ -------------TTFFSCP----------------DPGSCH-SCLEVFPSIEYQCMDQN FSKVP---MDIP-----------------------ASTQKLDLSFNPLRSLAPRSFSRIT ELRILDLSRC---------------DIQK-IEDDTYEGLHNLSTLILT-GNPIQSLGIRA FYGLPKLQKLVVVETNLMSL--EDFPIGHIITLQELHLGHNSISS--------------- -----------------------------------LQLPSYFASFSSMKHLDLHL-NQIK NISDGDLEPVKLNP--NLT-LDLSENPIQYI----------------------HPGA--- -FKGI-HLSGLKLRSSFHNSTIMEAC-----------------------IKGMTGLKVGK LVLG-----NYKNDIQMTSFESSILDGLCEVDIGEFRMVQPSQF-PSDGNGVFKCLVNVS VLFLVNTDIDQLTNLPIFP----------------------------------------- ------------------------------------------------------------ --------------------------------------------------KLFSLSLTD- ------------------------------------------------------------ -----------CNFDIMPDLPSIS---LP--------------SLKELKVTHHKDLTTLS D-L--ALPNLQILDLSKNS----LNVLSCCSDKTFNTPNLKYLNLSYNAHISLSKNFM-G LENLESLDLQHTILKDHDKYPAFYS----------LINLRYLDISYTNT----------- ------------------------------------------------------------ --------HVKFKNIFTGMSNLK-----HLKMAGS--SFQDNILHD-IFKNLT------- --------------------------------------KLVSLNISYCQLE------RVS QET----MSPLHQLQVLDLSHNKLQTFDPFICMP-L-LNLQVLNCSSNSITALNGENLQE L--SRTLISIDLS--DNPFDCVCDHQIFFQWVKEHTHL-L---NR-SKPMTCQTPS---H MKDISV------------------------------------------------------ -----------QLFDDSTCHM-------KKTV-IAVSLLGIIVILLVLALVYKFYF---- --HL----MLLAGCKNIG-------GG-------ESIYDAFVIY--SS---------QD- --EDWVRKELVKNLE-E---GVPSFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVISEHFI-QSRWCKFEYEIAQTWQFLSSQAGIIF-IILQKVEK-SLLRQQMELYR LLNRN-TYLEWEDTNLG---RHVFWRRLRKALLDGRTKNPKGAAEEEFSQP-VSPT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP001002-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TLPTELITDLP SLGSLTLYHN---------------MLER-IE--QFADLPNLTSLDLT-YNELDTLQEDV FDKLPNLTQLFLNSNKLTSL--PSGLLKRNTKLTVFRADNQRGSGL-------------- -----------------------------------VLGDELFAGLTMLEDVSVSN-CKLT TLSAGLFTVASK--LTKLN-LSDN-K-LQSL----------------------PENL--- -LRHSSNLKELYLQNNELMNKLPDTL-----------------------LQ--------- -------------------------------------ISNL------------------P KLETLYLDKNKLKHVSQ------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------FTTLP-NLMYLNISSNQLVKLQE NVFS-RLPKLKILDLSSNK----LKRLA-TD------------------------LFM-E NNHLEILDLSSNKLT-----------------RLATD----LLSENNHLEV--------- -FKAD------------------------------------------------------- ---NQ---KCSELCKCYKRPVDQ---AAIINCTAA--NLTL-VPV--TKIPSI------- ------------------INCTF--IE---------------LHLEQNKLN------ALS NGS-----EGWNTIRRLYISNNSFTTL-PGDRLP---EQLELLDVSGNQLTEVDAAFIIK LNHTA-LRNISLS--ANPWDCHC-ENPLLAFAVDNAAR-I---TDFSTLQC-SNGQ---P INSATL------------------------------------------------------ -----------NELCAWTTTL-------SFYI-SSAVSLLLIVCLLAIWLYMKYSLEIKV WLFKHNLLQWLVT-EEQI-------DM-------DKRYDAFISY--SH---------KD- --EEFVTDQMLPRLE-S---EELNFKICWHVRDFMPGEMIASQ-------IT-KAVE-DS RRTIIILSHNYL-ESVWGQMEFSTAYLQSLEDKRNRVIP-IIYQDIGD--IDQLDPELQA YLKTN-TYVRW------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000009600 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------AAERCDDWGVDTMK QIQIYDGEPA---------------KIKCPLFETFLK-----YNYSTA-HSAGLTLIWYR IAQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -YRL--PDNHISKDKDTL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFWPALLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVPKDQHSCVS HSIK-PTEEMFYLEHANQK----ITCPDIDGF---------------------------Y PPSVTPTVKWYLDCNSVDGFYERYP---------QGPKLVIGIVRSAY------------ ------------------------------------------------------------ --------KGNYTCIVTFKDHGR-----TYNLTRT------------------------- ------------------------------------------IKMKVV--G------SPN KALP-PQFISPNEKVVYELEAGDDLILPCEVFFT------FLKDSRTEVWWTIDGRNTVD IT-DPKIKVTQSY--VDFEDKTLVRTLTVAKATAEELK---------RNYTCHARN---A KGEERS------------------------------------------------------ -----------QAVVRMKVVAPK----YTVEL-ACGLGATILLVVVLIVIYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDVYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTTEA-------VF-DFIQ-RS RRMIVVLSPDYLTEKSISLLEFKLGIMCQNAIAT-KLIV-VEYRPLQC--TH--PSIL-Q LKESV-SFVTWKGEKSK-RSGSQFWKALRLALPLRSLSAS-AGWNESCSSQSDISLDPIQ RRRSRLKGQPDPRGATPVTLTPGRTASASASKAKQRAKHFLTCRCCGTPCDGSSGHKQRA VAE----PRWDGHLCTPGSGRAPAPALQGRGRAEPPPAQGPALALCHYSDLSNNNDFYVL ------------------------- >A_aegypti_AAEL000057-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MDLSDNYF-QGFRDLT----------------TLRLDFG-IENL--PTSLFKELTM LERLT--LTAQL--KKLPIDLLINQ----------NQLVELILKNNRIEEIPFDFFRHQN NLIHLDLSAN---------------RLQS-IAEITFANLTSLIHLDMS-HNAIQSVHANA F----------------------------------------------------------- ------------------------------------------HNMQKLKYLSLKS-NELT HVPPTLLKGLTL--LANLD-LSAN-Q-LRLL----------------------PPDL--- -LRNHTQLFRSDLSKNDI-ETLPEML-----------------------FETNAALQYVN ISHN------------------------SLITLPSKLFHTL------------------Q KLISLDLSNNQLSSLDPDIF-EQSP----------------------------------- ------------------------------------------------------------ --------------------------------------------------YVIFLYLQN- -------------------------------------------NHLWFAGS--------- -----------LYR---NEHDLEESSFSP--------FWPIRMQLRELNLRNNSIDRVDI AW-I-ESPELKKLDLSYNK----LSKFDNDD------------------------FKF-R SNE-MVVDLEFNQIAMLSLMAMDAT---KGS-----DGFNLFKLNHNPLNCDCQVTSFVQ FLQM--TGHVYRRWRFTVDHLRCVEPDLNRGINVVKVN--VANLLCKI-----------D -E------HCPERCSCFVRKSNE---SVLVNCEQK--NLTK-LPN--L---TN------- ------------------VSLNFNDVE---------------LYLKNNSIK------SFD LPT----SCGYEKVKKFDASYNQFQNL--SSDLL---LGVKILDISNNNLSSFIELT-NL LNNSRQLSSVKLS--SNPWQCDCPSIDHLRVIQTTSDR-I---EDSKYMRC-SDGR---D LNLLTV------------------------------------------------------ -----------SDVCHVDVIT-------TIII-SMCLVI--ILILLITFVAYAYQIEIKI WLFTNNLCLRLVT-EEEI-------DK-------DKLYDAFVSY--CH---------QD- --EEFVSSTLVPRLE-T---APMNLKVCWHMRDWNPGEVITTQ-------IV-HSIE-NS RRTIVVLSRDFL-ESSWGQLEFRTAHVSSMAEKRVRVII-IIYGDLGD--EDRIDSEMKA YLKTN-TYIKW-----G---DPWFWQKLRYAMPHPARV-KGVRWYR---------E---- ---------------RNRVDIAPTVEVN-------------------------------- ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0084432 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSRLKAASELALLVIILQLLQWPGSEASFGRDACS----EMSIDGLCQ CAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQM RRCMLPGHTPIASILDYLGIVSPT---------------------------TLIFES--- DNLGMNITRQHL-DRLHGLK----------------RFRFTTRRLTHI--PANLLTDMRN LSHLE--LRANI--EEMPSHLFDDL----------ENLESIEFGSNKLRQMPRGIFGKMP KLKQLNLWSN---------------QLHN-LTKHDFEGATSVLGIDIH-DNGIEQLPHDV FAHLTNVTDINLSANLFRSL--PQGLFDHNKHLNEVRLMNNRVPLA-------------- -----------------------------------TLPSRLFANQPELQILRL-R-AELQ SLPGDLFEHSTQ--ITNIS-LGDN-L-LKTL----------------------PATL--- -LEHQVNLLSLDLSNNRL-THLPDSL-----------------------FAHTTNLTDLR LEDN------------------------LLTGISGDIFSNL------------------G NLVTLVMSRNRLRTIDSRAF-VSTN----------------------------------- ------------------------------------------------------------ --------------------------------------------------GLRHLHLDH- -------------------------------------------NDIDLQQPL-------- -----------------LDIMLQTQINSP--------FGYMH-GLLTLNLRNNSIIFVYN DWKN-TMLQLRELDLSYNN----ISSLGYED------------------------LAF-L SQNRLHVNMTHNKIRRIALPEDVHL------GEGYNNNLVHVDLNDNPLVCDCTILWFIQ LVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE--PQTLICPL-----------D FSDDPRERKCPRGCNCHVRTYDK---ALVINCHSG--NLTH-VPR--LP---N------- ------------------LHKNMQLME---------------LHLENNTLL------RLP SAN----TPGYESVTSLHLAGNNLTSI-DVDQLP---TNLTHLDISWNHLQMLNATVLGF LNRTMKWRSVKLS--GNPWMCDCTAKPLLLFTQDNFER-I---GDRNEMMC-VNAEMPTR MVELST------------------------------------------------------ -----------NDICPAEKGV-------FIAL-AVVIALTGLLAGFTAALYYKFQTEIKI WLYAHNLLLWFVT-EEDL-------DK-------DKKFDAFISY--SH---------KD- --QSFIEDYLVPQLE-H---GPQKFQLCVHERDWLVGGHIPEN-------IM-RSVA-DS RRTIIVLSQNFI-KSEWARLEFRAAHRSALNEGRSRIIV-IIYSDIGD--VEKLDEELKA YLKMN-TYLKW-----G---DPWFWDKLRFALPHRRPV-GNIGNGALIKTALKGST---- ---------------DDKLELIKPSPVTPPLT----TPPAEATKNPLVAQLNGVTPHQAI MIANGKNGLTNLYTPNG----------KSHGNGHINGAFIINTN---------------- ----------------AKQSDV--- >P_pygmaeus_ENSPPYP00000021907 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMSASRLAGTLIPA------------------------------------ -------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFP ELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQNLALGA FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------- -----------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ SIYCKDLQVLHQMPLLNLS-LDLSLNAMNFI----------------------QPGA--- -FKEI-RLHKLTLRNSFDSLNVMKTC-----------------------IQGLAGLEVHH LVLG-----EFRNEKNLEKFDTSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLANVS SFSLVSVTIKSVKDFSYNF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------GWQHLELVN- ------------------------------------------------------------ -----------CKF---GQFPTLE---LK--------------SLKRLTFTANKGGNAFS E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNDVITMGSNFL-G LEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- ------------------------------------------------------------ --------RVAFNGIFNGLSSLK-----VLKMAGN--SFQENFLPD-IFTELR------- --------------------------------------NLTFLDLSQCQLE------QLS PTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---D KQGMPV------------------------------------------------------ -----------LSL-NITCQM-------NKTI-IGVSVFSVLVVSVVAVLVYKFYF---- --HL----MLLAGCIKYG-------RG-------ENTYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPTFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR LLSRN-TYLEWEDSVLG---RHL-WRRLRKALLDGKSWNPEGTVGTG-NWQ--EATSI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP010634-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------M-------NKRYDAFISY--AH---------KD- --EEFVTKELLPRFE-S---EELNFKICWHVRDFMPGEMIANE-------TT-KAVE-ES RRTIIILSLNYL-ESVWGQIEFSTAYLQSLADKCNRVIP-IIYQDIGD--IEQLDPQLQA YLKTN-TYIRW-----D---DPWF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP010669-PA MYCVCLTVLLVADTSTGNDCTITNR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SRVCWIVE CPGSNVHLSINVKNRKLNVTCSDKPNFELLRDQPNLRSLTFDQLIYQ----DCP------ -------------------------------------------------LPVGYQSLLEL LSAFLDH----------TQLSYIV---------------------------ELILINNAD LSANVTLDPPLF-AGLHKLQ----------------TLVIDNY-AV-SFDKP------LP LQQLP--SGVNR-FSGSILHQLQQK----------QHRHSIAEGDWEMNIMPSGLVSIVP NLQMLTLHRH---------------NFKQ-IE--HFAKLPSLTYFNIS-SNQLMSLHDDM FYGLPNLTFIDLSSNKLTRL--SAKLFLMNKNLNNFIADNQNGSGL-------------- -----------------------------------VLEDKLFADLRRLIKVSVSN-CKIT ALPECLFAGATG--ITFID-FSSN-K-LQSL----------------------PEHL--- -FRGLSNLRWLYLQDNELMRMLPDTL-----------------------LQDAINLRVLH LCYN------------------------KLTMLNKHLLKSL------------------R HLEKLHLEHNQLHMIDVDAFTSQTE----------------------------------- ------------------------------------------------------------ --------------------------------------------------SLITLNLSR- -------------------------------------------NSITLNEDN-------- -------RDVFYSN---EEINI--TSGII--------FSTLN-KVKYLDLSFNAIVKILD PFKN-FMKGLRTLDLSHNL----ITHVGYKD------------------------LLF-P SPNIDLVNLESNKITH-LDFDRSRI---ETRHRLPKE----ILLANNPLNCDCMSYPLVT YLKAEPDSS----KSFLLKGLQCAHPSKLFGLQPQDVQ--LEDLVCEI-----------D -TFSE---FCPAECKCYKRAVDQ---CAIVNCNAA--NLTR-VPI--IHSPSN------- ------------------IGRNF--IE---------------LHLAQNKLH------YLS NAG-----EGWNFVRWLNVSNNSLGSL-SAESLP---EMLELLDVSGNQLTEIDAALIVK LNQST-LHNISLA--LNPWDCYC-ENQLLTFVVNNVAR-I---TDYYTLQC-IDGK---P INLATL------------------------------------------------------ -----------KELCGTIILS-------RLYI-SVAVSMASVGCLLCIWLYAKFNLAIKV WLFRHNLLQWLVT-EEHT-------DM-------NKRYDAFISY--SH---------KD- --EDFVTKELLPRLE-S---EELNFKICWHVRDFVPGEMIANELLYYSFQIA-KAVE-ES RRTIIILSLNYF-ESMWGQMEFSAAYLQSLVDKHNRVIP-IIYQDIGD--IDQLDPQLRA YLKTN-TYVRW-----D---DPWFWDKLHYAMPRKRRP-KDVQT----TDNMRMAS---- ---------------GDK---LNLPIIMTP-------------------PIK-------- ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000008190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMARARLAAALIPA------------------------------------ -------------TAILSCL----------------RTESWD-PCVQVVPNISYQCMELN LYKIP---DNIP-----------------------ISTKMLDLSFNYLRHLGSHNFSSFP ELQVLDLSRC---------------EIKI-IEDDTFQGLNHLSTLILT-GNPIQSLAWGA FSGLSSLQKLVAVETNLVSL--NDFPIGHLKNLKELNVAHNFIHS--------------- -----------------------------------FKLPEYFSNLPNLEHLDLSN-NKIQ NIYYEDVKVLHQMPLLNLS-LDLSLNPLDFI----------------------EPGT--- -FKEI-KLNGLTLRSNFNSSHVMKTC-----------------------IQGLAGLKTNR LVLG-----EFKNERKLQRFDRSFLEGLCNLTIEQFRIAYLDKF-SGDDTDLFNCLANVS VISLLSISLGSLQALLKDF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------RWQHLEIIN- ------------------------------------------------------------ -----------CDF---DKFPALK---LS--------------SLKKFVFTDNKDISTFT E-F--QLPSLQYLDLKRNH----LSFKGCCSHTDFGTTNLKHLDLSFNDVITLGSNFM-G LEQLEHLDFQHSTLKQINAFSAFLS----------LRNLRYLDISYTNI----------- ------------------------------------------------------------ --------RIVFHGIFTGLVSLQ-----TLKMAGN--SFQNNLLPD-IFTELT------- --------------------------------------NLTVLDLSKCQLE------QVA QTA----FHSLSSLQVLNMSHNKLLSLDTFLYEP-L-HSLRILDCSFNRIMASKEQELQN L--PRSLTWLNLT--QNAFACVCEHQSFLQWVKDQRQL-L---VG-AEQMMCAEPL---D MEDMPV------------------------------------------------------ -----------LSFRNATCQL-------SKTI-ISVSVVTVLLVSVVGVLVYKFYF---- --HL----MLLAGCKKYG-------RG-------ESTYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKLEK-SLLRQQVELYR LLSRN-TYLEWEDSVLG---RHVFWRRLRKALLAGKPQSPEGTADAETNPQ-EATTST-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000001909 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMPRLRLAGTLVPA------------------------------------ -------------MAFLSYL----------------RPEIWE-PCVEVVPNITYQCMEKN LYKIP---DNIP-----------------------FSTKNLDLSFNLLEHLGSHSFLHVS ELHFLDLSRC---------------KIHT-IEDDAYQGLKNLSPLILT--NPIQSLSPQA FSGLSNLQKLVAVETHLTSL--GDFPIGHLKTLKELNVAHNLIHS--------------- -----------------------------------FSIPDYFSNLSSLEHLDLSN-NKIQ SIYHKDLRVLHQMPLGTLS-LDLSLNPIDFI----------------------QPGA--- -FEAI-RLHELILKSNFKSTNIMKIC-----------------------IQGLSGLEVHR LVLG-----EFKNERNMKNFDKSALEGLCNLAIEEFRLAYIDDL-EGNITDLFDCLENVS VMALVHMYIDNQEIFPKDF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------SWKSLEFIN- ------------------------------------------------------------ -----------CEFS--ENIFFLK---LS--------------SLRRLIFTANKGVRTFP E-L--NTPSLEFLDISNNG----LSLQSCCSVNSLRLTQLKHLNLSFNGVITMTSNFV-G LEQLEHLYFQHSNLRNINEFSIFLS----------LNNLLYLDISYTHI----------- ------------------------------------------------------------ --------RVAFRGIFDGLYSLR-----VLKMAGN--AFQDNRLLN-IFTEMT------- --------------------------------------SLTTLDLSSCQLE------QVY QGA----FESLPRLESLNMSHNNLLVLDTLTYKC-L-YSLQVLDLSFNHIGNITEPGQQH F--PSNLTLLHLT--KNAFVCDCEHQIFMQWIKDQRRL-L---VE-VEQMVCITP----- -PNMPV------------------------------------------------------ -----------LSFTNATCQI-------SKTI-ISVSVFSVLVVSFAVVLVYKFYF---- --PL----MLLVGRRKYG-------RG-------ESVYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFRLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSHAGIIF-IVLQKVEK-SLLRQRVELYR LLSRN-TYLEWEDTVLG---RHIFWRRLRKALLDGKTLSPEGMARAENNQQ-EAMTLI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000018871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SERCDDWGLDPMR QIQVYEGEPA---------------HIQCPLFEHFLK-----FNYSTA-HSAGLTLIWYW TGQDQDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PDNRISKEKDLI------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVIQKS--SCFS SRMK-VPREYMYMEHTLQS----LRCPNIEGF---------------------------F PSSVQPKVVWYMICEVVNNYYKVDV---------NGPELIFTYVLTSN------------ ------------------------------------------------------------ --------SANYTCVVTYPENGR-----MFNLTRT------------------------- ------------------------------------------VEVKVV--A------SPI YATA-PDIFSPNDHITYDKEPGEELELPCKVRFP------FLKDSRDEIWWTVDGRKPDE TM-NITINQSETV--EIVGDKTITRILSIKKVTSDDLK---------RNYTCHARN---D KGESVK------------------------------------------------------ -----------QAIVKQIVVPPR----YTVEL-ACGFAVTIVLIIILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYLTEKSISLLEFKLGVLCQNSIAT-QLVV-VEYRPLEQ--PH--PSIL-Q LKDSV-SFVSWEGERSK-RSGSKFWKALRLALPLRSLSAG-SGWNESCSSQSDISLDHIQ RRRGRLKVPQEFLSSRRAA---GAGPPTPGAVAKHQGKPSVACRCCVTYCKGEKPLRNKN RAEAPIQPQWETHLCKPVPQQVATHWVQNGSRLSTPAPQISALALHHFTDLSNNNDFYVL ------------------------- >T_guttata_ENSTGUP00000003444 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------WDLPLLQVTPNTTFRCTGLN ISGVP---DGVP-----------------------NTTQNLDLSFSNLKSLGSNYFASVP ELQILDLSRC---------------HLHT-IEDNSFMDLPRLSTLVLT-ANSLQHLGKAA FYGLTSLKKLVLVETNRTSL--SELPIGHLHTLQELNLGHNSITS--------------- -----------------------------------LKLPKYFTNMTSLRLLSFSS-NKIT SISRGDLDALREGNRLNLT-LVLSLNNIKSI----------------------EPGA--- -FAGI-HLAELALRSAFEKPT-MQTA-----------------------LQGLAGLQVSR LIVG-----EFRNIERLQDFEGRLLDGLCQVQMEEFVLICLRGF-KDDTDTLFNCIGNVS TIRLVDLGLKEISQVPVWS----------------------------------------- ------------------------------------------------------------ --------------------------------------------------KVRQLECKK- ------------------------------------------------------------ -----------CHF---EDVPAQKLSLFK--------------ELRMLRINDNRNLKTFE HKFK-GLSNLEVIDLSENR----LTFSSCCSPQFQNCPNLKHLNLSFNSNIRLTGDFT-N VKNLLYLDLQHTTLFGPGSYPVFLS----------LQRLIYLDISHTKT----------- ------------------------------------------------------------ --------EVKSQCTFCGLNSLQ-----VLKMAGN--SFADNKLAN-NFKNLS------- --------------------------------------HLHTLDISSCKLE------HVD QST----FDALSELKELNISNNKLMTFDPVVYQP-L-QALRVLDFSRNQLAVLLDPAREI L--PDSLVLLDIS--QNLFDCSCVYLDFLKWVKEKQEL-L---QN-EELMLCHTPS---Y VANVSL------------------------------------------------------ -----------PSFDLSSCHI-------SAGQ-VASPVVVLFCVVVFLFLVYRYYF---- --QLYYSMVLLSGCKHYA-------ER-------GDTYDAFVIH--SS---------KD- --QEWVMKELVEPLE-G---GTPRFRLCLYYRDFLPGVPIVTN-------IIEEGFL-SS RNVIAVISADFL-QSKWCSFEFDIAQSWQLVEGKAGLIM-IVLEDVNK-ALLRQRLGLSR YLRRN-TYLEWKNKEIS---KHIFWRQLIGVLLEGKNWNH-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_rerio_ENSDARP00000055005 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MRL ----------------VGTMTAII------------------------------------ -------------LIMFILA----------------QGLECSQTCKCD-QMYFCNCSSNN LHQVP---T-VP-----------------------SDVLGLDLSFNQIESINMTDLSSYN ELIILNLHKN---------------KLRH-IHRDAFKSQHNLEVLDLS-LNNLNNLSPSW FHKLKSLQQLNLVGNPYST----------------------------------------- -----------------------------------VGPAPIFKSLVNLRTLHLGS-PSLR ELHKNGLDVLTH--LDEMT-FF-GSN-LRSY----------------------ENGS--- -LKAARPIGSVSLSLQNLFESDPELVSKV--------------------LQDVSH-PETL LIIK-----DVT--MKTNTST-EPFKMVKEGGTKSLTFQNS-STTDQALTSFLEFMDG-S PLSFIGLEDIQFVGIGEW-QKAK---YTHHD----------------------------- ------------------------------------------------------------ --------------------------------------------------SLRTAYLRN- ------------------------------------------------------------ -----------IEI---EGFFGFSSMIEL--------GFLLKH-FHNVSVINATVFVIPK ETTF-LLKNLEYMDLSQNL----LTDLTIQP------------------TLYTGS--G-A YQNLNMLNVSQNVLKSLGLMSRLVT---------NLKKLKYLDLSYNSFV---------- ------------------------------------------------------------ --------SMPEK--CSWPVTLR-----FLNLSST--KL-STLTPC-LPSSLT------- -----------------------------------------VLDLSENDLK------AFK Q--------RFPHLTTLILTGNRLMKLPDGKLF----PSLNTLLIQRNALRMFNQ---SS LRSFKTLLYLEAG--ANNFVCSCKFVSFFKKDVEDLIT-L---QDGRQNYVCNTPF---T LRGNAI------------------------------------------------------ -----------DSVRLSVFECYM-----IPAV-SVLCFGIITALGLVVLTCHKLHV---I W-YLQMTKAWIQAKRKPA---VGRLPE-------ELRYDAFVSY--SQ---------HD- --AEWVEEILVAELE-D---TQPSFSLCLHKRDFRPGRWIVDN-------II-DSIE-KS YRTLFVLSEHFV-SSEWCRYELDFSHFRIMDEHNDSAVL-VLLEPIKKETIPKRFCKLRK IMNSR-TYLEWPEDEDK---RDEFWSNLRAALQRDEC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000020856 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------LQVVANITYQCMELD LSEVP---AEIP-----------------------SSAQNLDLSFNPLGTLVPKGFSMLP DLRMLDLTRC---------------QIQV-IEDDAFRGLCNLSTLILT-GNPVQRLGASA FSGLKMLQKLVAVEMQVVSL--EDLPLGHLTALRELNLGHNFIRS--------------- -----------------------------------SKLPSYFAHLVSLQYLNLYK-NKIS MILLEDLNVLKQRQQPLLT-LVLSLNNILNI----------------------ELGS--- -FEGL-HLQALEMRGCFNDVNVTKTC-----------------------INALAGLQVHQ LVLG-----DFRENHNDMPEDFGVFDGLCKVDIEEFRIVYYKGL-IYNTNIFSNCLLNVS VLRVVSTSLNEVANLPAAT----------------------------------------- ------------------------------------------------------------ --------------------------------------------------RWQTLHFNR- ------------------------------------------------------------ -----------CGF---SEVPAKSLRPLT--------------QLKELQITENDELKEFE QDF--CLPNLESLDLSRNR----LNFKSCCSETLFGTPRLKHLNLSFNFHIDITVNFM-G LVELQYLDLQHSKLNGPGHFSAFVL----------LTKLIYLDISYTNT----------- ------------------------------------------------------------ --------HIDSAGTFYGLESLQ-----VLKMAGN--TFHNRFLKD-NFRNVT------- --------------------------------------RLLYLDISNCQLE------QVS HQA----FTSLHQLQELNISHNKLLTF-PVACAP-L-QSLKVLDCSFNLIAAPEEEALRS L--SQTLVRLDLS--QNPLDCFCDHLGFLQWVKDHRKQ-L---WK-PERMTCARPS---D LANTLV------------------------------------------------------ -----------LDFKPSVCEV-------KRIL-MWVSVVGVLAIAFIVVLVYKFYF---- --HL----MLLSGCKRYG-------PG-------GNTYDAFVIY--SS---------QD- --EEWVRNELVKNLE-E---GVPPFQLCLHYRDFMPGVAITSN-------IIQEGFH-KS RKVIVVVSKHFM-ESRWCSFEFEIAQTWQFLESQAGIIL-IVLQKVDK-SQLQRRMGLSR YLHRN-TYLEWEDNKIS---RHIFWRRLRNALLDGSV--PSGIREKVGGIN-ESITGI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000005321 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MSI Q---AKHKSRMTNTWRVLAIYVIL------------------------------------ -------------AASLSEQ----------------QALKQ-ACPSCD-GSQLCNCSSMG LDFIP---PGVT-----------------------AIITVLNLAHNGIKRIQSQDLQQAV NLRALLLQSN---------------KISS-IDEDSFWSLEKLELLDLS-NNSLAHLSPVW FGHLFSLQHLHLEGNSYRD----------------------------------------- -----------------------------------LGQSSPFSSLKNLSSLHLGN-PQFS VIRHGNFEGIEL--LHKLW-ID-GSN-LSQY----------------------EQGS--- -LKSIKQINHMILNLRN-----GYIFSEI--------------------VRDLLH-SVTW LEVT-----EIK--LPVERKS-LVQNSTRPFRIQKLTFKEA-FFTDETISRTIVSLKEIT SLKELEAINCVLEGKGIW--NTKEIARSGQS----------------------------- ------------------------------------------------------------ --------------------------------------------------FVETVTVTK- ------------------------------------------------------------ -----------IMI---QNFHLFFDLEGM--------ESQINK-LKRLSIASSNVFMVPC KLAR-HFSSLLYLDFHDNL----LVNKRLDE------------------T--ICE--H-S WPSLQTLNLSQNSLKSLEQTAKYIS---------RLPKLNNLDISQNNFG---------- ------------------------------------------------------------ --------EIPDV--CDWPKSLK-----YLNLSST--QI-PRVTTC-IPQTLE------- -----------------------------------------VLDVSGNNLK------EFG L--------RLPLLKELYLTRNQLKTLPGAAPI----PNLVSLSVSRNKLNSFSK---EE FESFRRMKLLDAS--GNNFICSCEFLSFIHHEAGISQV-L---VGWPDKYVCDSPL---A VRGAQV------------------------------------------------------ -----------GAVHLSLMECHR-----SLVV-SLICVLVFLVILLLVAVGYKYHM---V W-YLRMTWAWLQAKRKPK---RAP-PK-------DVCYDAFVSY--SE---------ND- --SDWVENTMVRELE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KS RKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIQSKAIPKRFCKLRK IMNTK-TYLEWPAGEEQ---QQVFWENLKGALKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000036398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMSASRLAGTLIPA------------------------------------ -------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFP ELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------- -----------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ SIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----------------------QPGA--- -FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVHR LVLG-----EFRNEGNLEKFDKSALEGLCNLTMEEFRLAYLDYY-LDDIIDLFNCLTNVS SFSLVSVTIKSVKDFSYNF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------GWQHLELVN- ------------------------------------------------------------ -----------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFL-G LEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- ------------------------------------------------------------ --------RVAFNGIFNGLSSLE-----VLKMAGN--SFQENFLPD-IFTELR------- --------------------------------------NLTFLDLSQCQLE------QLS PTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---D KQGMPV------------------------------------------------------ -----------LSL-NITCQM-------NKTI-IGVSVLSVLVVSVVAVLVYKFYF---- --HL----MLLAGCIKYG-------RG-------ENIYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRRQVELYR LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >D_melanogaster_FBpp0075360 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MLATTHMLYVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDITL VCHLRTINS------ELENTNFSVIQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRD LTIEYCKLGNLTDG-SFRGLQELR-------------------------NLTIRTHNGDW STMSLEMASNSF-VEFRQLE----------------RLDLSLNNIWLI--PDGMVCPLKS LQHLN--ASYNK-IQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALG RLTHLNMAKN---------------SMSF-LADRAFEGLLSLRVVDLS-ANRLTSLPPEL FAETKQLQEIYLRNNSINVL--APGIFGELAELLVLDLASNELNSQWINAATFVGLKRLM MLDLSANKISRLEAHIFR-PLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSR-NRIS VIEQRTLQGLKN--LLVLS-LDFN-R-ISRM----------------------DQRS--- -LVNCSQLQDLHLNDNKL-QAVPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLR MTEN------------------------SLTHIRRGVFDRM------------------S SLQILNLSQNKLKSIEAGSL-QRNS----------------------------------- ------------------------------------------------------------ --------------------------------------------------QLQAIRLDG- -------------------------------------------NQLKSIAGL-------- -------------F---TELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGN YFEIESELSLSTFDASYNL----LTEITASS---IPNSVEVLYLNDNQISKIQPYTFF-K KPNLTRVDLVRNRLTTLEPNALRLS------PIAEDREIPEFYIGHNAYECDCN----LD WLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCD FQACDCKMECPDRCSCYHDQSWT---SNVVDCSRA--SYEQTLPSH-IPMDSTQLYLDGN NFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLK------ALN GNE----FQGLDNLQELYLQHNAIATI-DTLTFT-HLYHLKILRLDHNAITSFA----VW NFLPSYLNELRLA--SNPWTCSCEFIDKLRDYINRHEY-V---VDKLKMKCD-VISGNST QQMVIYPGSGEPAS-------------------------LPVVQCSQTLPLG---LDNNF NYAEQAGGENASNATSTKMILNQPPKLDYIPI-LVAILTAFIFVMICISLVFIFRQEMRV WCHSRFGVRLFYNAQKDV-------DKN----EREKLFDAFVSY--SS---------KD- --ELFVNEELAPMLE-M---GEHRYKLCLHQRDFPVGGYLPET-------IV-QAID-SS RRTIMVVSENFI-KSEWCRFEFKSAHQSVLRDRRRRLIV-IVLGEVPQ---KELDPDLRL YLKTN-TYLQW-----G---DKLFWQKLRFALPDVSSS-QRSNVAGQSCHVPINHASYHH HHHV------------------HQQAM-PLPH----SVHHHQQ--QFMLPPP-------P QQPGSFRRQPSLHQQQQQQQQIRGNNNTTQQQQQQQAALLMGGGSVGGPAPQMIPLAGGI QQQSLPLPPNQQPTPASRNLHM--- >G_gorilla_ENSGGOP00000007772 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VVPNITYQCMELN FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFP ELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------- -----------------------------------FKLPEYFSNLTNLEYLDLSS-NKIQ SIYCTDLRVLHQMPLLNLS-LDLSLNPMTFI----------------------QPGA--- -FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVRR LVLG-----EFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLTNVS SFSLVSVTIERVKDFSYNF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------GWQHLELVN- ------------------------------------------------------------ -----------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS E-V--DLPSLEFLDLSXXX----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X XXXXXXXXXXXXXXXXXXXXXXXXX----------XXXXXXXXXXXXXX----------- ------------------------------------------------------------ --------XXXXXXXXXXXXXXX-----XXXXXXX--XXXXXXXXX-XXXXXX------- --------------------------------------XXXXXXXXXXXXX------XXX XXX----XXXXXXXXXXXXXXXXXXXXXXXXXXX-X-XXXXXXXXXXXXXXXXXXXXXXX X--XXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXX-X---XX-XXXXXXXXXX---X XXXXXX------------------------------------------------------ -----------XXX-XXXXXX-------XXXX-XXXXXXXXXXXXXXXXXXXXXXX---- --XX----XXLAGCIKYG-------RG-------ENVYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000363089 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMSASRLAGTLIPA------------------------------------ -------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELN FYKIP---DNLP-----------------------FSTKNLDLSFNPLRHLGSYSFFSFP ELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------- -----------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ SIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----------------------QPGA--- -FKEI-RLHKLTLRNNFDSLNVMKTC-----------------------IQGLAGLEVHR LVLG-----EFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY-LDDIIDLFNCLTNVS SFSLVSVTIERVKDFSYNF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------GWQHLELVN- ------------------------------------------------------------ -----------CKF---GQFPTLK---LK--------------SLKRLTFTSNKGGNAFS E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFL-G LEQLEHLDFQHSNLKQMSEFSVFLS----------LRNLIYLDISHTHT----------- ------------------------------------------------------------ --------RVAFNGIFNGLSSLE-----VLKMAGN--SFQENFLPD-IFTELR------- --------------------------------------NLTFLDLSQCQLE------QLS PTA----FNSLSSLQVLNMSHNNFFSLDTFPYKC-L-NSLQVLDYSLNHIMTSKKQELQH F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-VERMECATPS---D KQGMPV------------------------------------------------------ -----------LSL-NITCQM-------NKTI-IGVSVLSVLVVSVVAVLVYKFYF---- --HL----MLLAGCIKYG-------RG-------ENIYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKSWNPEGTVGTGCNWQ--EATSI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000031395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMSPTRLVGILIPA------------------------------------ -------------MAFLSCL----------------RPESWD-PCMQVVANTTYQCMELN LSKIP---NNIP-----------------------TSTEKLDLSFNPLRHLGSHCFSNFP KLQVLDLSRC---------------EIQV-IEDDAYQGLNHLSILILT-GNPIQRLFPRA FSGLSSLKTLVAKETKLTSL--EDFPIGHLKTLKELNVAHNLIHS--------------- -----------------------------------FKLPAYFSNMPNLENVDLSN-NKIQ NIYREDLQVLHHMPLLNLS-LDLSLNPLYFI----------------------QPGS--- -FKEI-KLHKLTLRSNFNSTDVMKTF-----------------------IQGLAGLKINQ LVLG-----EFKNERKLESFDNSLLEGLCNLTIEKFRIAYFDSF-SKDTTNLFNQLVNIS AISLAHLYLDTPKYLPKNL----------------------------------------- ------------------------------------------------------------ --------------------------------------------------RWQRLEIVN- ------------------------------------------------------------ -----------CNL---EQFPAWE---LD--------------SLKEFVLTSNKGMNTFA D-M--KMESLEFLDLSRNR----LSFKTCCSHSDFGTTRLKHLDLSFNEIITMSSNFL-G LEQLEYLDLQHSSLKQASDFSVFLS----------LRNLRYLDISYTRT----------- ------------------------------------------------------------ --------EVAFQGIFDGLVSLE-----VLKMADN--SFPDNSLPN-IFKGLT------- --------------------------------------NLTILDLSRCHLE------RVS QES----FVSLPKLQEINMSHNSLLSLDTLAYEP-L-LSLQILDCSFNRIVAFKEQGQQH F--PSNLVSLNLT--RNNFACDCEHQSFLQWVKDHRQL-L---VE-VEQMVCAKPL---D MKDMPL------------------------------------------------------ -----------LSFRNATCQR-------SKTI-ISVSVFTVLMVSLVAVLAYKFYF---- --HL----MLLAGCKRYN-------RG-------ESTYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFY-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-SLLRQQVELYR LLSRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKPWSPEGTEDAPQNLQVDASTKS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000008292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MMPPTRLAGTLIPA------------------------------------ -------------MAFLSCL----------------RPESWD-PCVQVVPNTTYQCMDLN LYKIP---ENIP-----------------------TSTKELDLSFNPLKELGSHSFSNFP ELQVLDLSRC---------------EIEM-IEDDAYQGLNHLSTLILT-GNPIRSLALGA FSGLSSLQTLVAVETKLSSL--EKFPIGHLKTLKELNVAHNLIHS--------------- -----------------------------------FKLPEYFSKMPNLEHLDLSN-NKIQ NISHEDLRVLHQMPLLNLS-LDLSLNPLEFI----------------------QPDA--- -FKEI-KLHKLTLRSNFDSIDVMKSC-----------------------IQGLAGLKVNR LVLG-----EFKNERKLERFDTSALRGLHNLTIEEFRLAYIDNYSSKDSIDLLNCLANIS KISLVSLDLGNLQDFPKGF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------GWQDFELVN- ------------------------------------------------------------ -----------CRI---EGFPTLE---LT--------------SLKRLVFTSNKDMKSFN E-V--KLPSLEFLDLSRNR----LSFKSCCSEADLKTTRLKHLDLSFNDVISMSSNFM-G LEQLEHLDFQHSTLKQASDFPVFLS----------LKNLRYLDISYTNT----------- ------------------------------------------------------------ --------RVVFHGIFDGLVSLQ-----VLKMAGN--SFKDNFLPN-IFREMT------- --------------------------------------NLTTLDLSKCNLE------QVS QEA----FCLLPRLRVLNMSHNNLLFLDMLPYKP-L-HSLQILDCSFNRIVAFKWQELQH F--PSSLASLNLT--QNDFACVCEYQSFLQWVKDQRQL-L---VE-VEHLVCAIPL---Q MRGMPV------------------------------------------------------ -----------LGFNNATCQI-------SKTI-VGGSVFSILMVSVIAVLVYKFYF---- --HL----MLLAGCKKYG-------RG-------ESIYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIQEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLHKLEK-SLLRQQVELYR LLNRN-TYLEWEDSVLG---RHIFWRRLRKALLDGKPWSPAGTADAAESRQHDAETST-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL007619-PA MKVFGSSVKVQPYIRKFVFCNNCHRFGHKEESCKSNKRCGKCSRIHEEVEEQCPNEVKCL HCRKSDHRTTDPNCPSRQREISIKTMMSKKNLTYVEARELIAPLTTQYDVLADIAEFPAL PNTFAKMTAGRFTMRNNHQQQRNDILTNRSDERPLGAVKKPANSTPVGAKKMRIDDERQQ LIKDRNVEGSSKGAGLENRHVVSERESWDNIIRKANADAQETANRNVRGELANFYTALIQ CPGVTEELQETIKDTHRSIALLVISAIILLVRTQDVTSTSGKRFTCP----EESEAPNCS CEEFPSKTHFYCP--DFNPTLYVDVEDRMRVDFKCY-DEPHDFKSLP-NLAIGSVKLLTV VDCALDEDRPILESFKFLEVANVR---------------------------SFVYNN--- HENGIHYNARYF-EGLEQLE----------------NLTLARG-VVSI--DKDTFSGFLN LKRLT--IEHNK--LNLQPGTFEAL----------SNLTYLGLVYNGIDEIQPGLFDGLE SLEALSLSYN---------------DIKS-LSAGSFNGLSSLRMLNLR-VNKIESFDANT FASLKELSRLEITLNPFVSL--PRGLFSENKKLKTLILTNNR-KLV-------------- -----------------------------------TLPEELLANLKELTVVNLSH-NGVG NLPESLLSGSLG--IIELN-LGYN-R-LNSL----------------------PEEL--- -LSDQLQLQVLNLDHNQL-ESIPDYF-----------------------LERNVELQTLY LSHN------------------------RLRSLSEKAFTKL------------------K NLKELHLENNQLQTIPQFLF-SGTP----------------------------------- ------------------------------------------------------------ --------------------------------------------------KLEEIYMQN- -------------------------------------------NQLALHANS-------- -----------FIN---QELSIADNDNTP--------FQVLQ-KLRILHLRNNSISTIFQ DWYI-NNLELQSLDLSFNK----LPGLSYTQ------------------------LQF-Q SN--ITLNLSNNEISQVLLIDDLDL---QPYQRI--N----VDLNHNPLNCNCNALKFIQ LIQSKPEHG----LQFNVDQLRCSEPPNLLDVTMDQLQ--TKDLLCDF-----------E -SAND----CPKDCQCAMRLVDY---TVIVNCSGR--GLTE-FPD--LPIPSQ------- ------------------LHEDFNALE---------------VHVENNRLT------KLP NLT-----KH-NEITQLYARNNSIQNL-LPHNIP---SKLRIIDLSQNLLEMIDDSTLAQ INRSSHLETIRLS--QNQWLCDCPASSFLIFVQQNSRL-I---SDMSAVRCHPSGK---S LDSITV------------------------------------------------------ -----------NELCFEDYTT-------KIVI-CFAIAVFGLLVGLISLLFFRYQTEVKV WLFTHNLFLSLIT-EEEL-------DK-------DKLYDAFISY--SH---------LD- --EEFIVDELIPKLE-N---DPMNFKTCWHVRDFMPGEMIMTQ-------IV-KSIE-AS RRTVIVLSKNFL-ESSWAKQEFRQAHVQSMEDNRVRVIV-VIYEDIGD--IDSLDGELKA YLKTN-TYVKW-----G---DPWFWQKLRYAMPHPLKV-KGIKS-----------A---- ---------------VSEIHLQQVTTKATPTA----V----------------------- ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000020672 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LGLS---- -SYVM------------------------------KRKFYLLLLSAATKRCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PDNRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SSMK-LPLHRLYIEYGVQK----ITCPNVDGF---------------------------F PPTVKPTITWYMGCKKIKNFNNVIP---------EGMNLSFLIALVSN------------ ------------------------------------------------------------ --------NGDYTCVVTYPENGR-----IFHLTRT------------------------- ------------------------------------------LTVKVVETG------SPK DALP-PQIYSPNDLVVYEKEPGEELLIPCTVYFT------FLKDARNEVWWTIDGKKPDD TSIDVTVNESVSL--TATEDEMRTQILNIKKVSAEDLK---------RNYVCHARN---A KGEVDK------------------------------------------------------ -----------AAKVKQKVIAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYVTEKSISMLEFKLGIMCQNSIST-KLIV-VEYRPLEH--PH--PSIL-Q LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQ RRRSRLKEPPELQGTERVA---GTS-AAPDTMSKHRGKPSAACRCCVTYCEGESHLRSKS RAEIHTQPQWETHLCKPVPQESETQWIQNGTRLEPPASQISALALHHFTDLSNNNDFYIL ------------------------- >M_mulatta_ENSMMUP00000039787 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MTSALRLAGTLIPA------------------------------------ -------------MAFLSCV----------------RPESWE-PCVEVVPNITYQCMELK FYKIP---DNIP-----------------------FSTKNLDLSFNPLRHLGSYSFLRFP ELQVLDLSRC---------------EIQT-IEDGAYQSLSHLSTLILT-GNPIQSLALGA FSGLSSLQKLVAVETNLASL--ENFPIGHLKTLKELNVAHNLIQS--------------- -----------------------------------FKLPEYFSNLTNLEHLDLSS-NKIQ NIYCKDLQVLHQMPLSNLS-LDLSLNPINFI----------------------QPGA--- -FKEI-RLHKLTLRSNFDDLNVMKTC-----------------------IQGLAGLEVHR LVLG-----EFRNERNLEEFDKSSLEGLCNLTIEEFRLTYLDYY-LDNIIDLFNCLANVS SFSLVSVSIKRVEDFSYNF----------------------------------------- ------------------------------------------------------------ --------------------------------------------------RWQHLELVN- ------------------------------------------------------------ -----------CKF---EQFPTLE---LE--------------SLKRLTFTANKGGNAFS E-V--DLPSLEFLDLSRNG----LSFKGCCSQSDFGTTSLKYLDLSFNDVITMSSNFL-G LEKLEHLDFQHSNLKQMSQFSVFLS----------LRNLIYLDISHTHT----------- ------------------------------------------------------------ --------RVAFNGIFDGLLSLK-----VLKMAGN--SFQENFLPD-IFTDLK------- --------------------------------------NLTFLDLSQCQLE------QLS PTA----FDTLNKLQVLNMSHNNFFSLDTFPYKC-L-PSLQVLDYSLNHIMTSNNQELQH F--PSSLAFLNLT--QNDFACTCEHQSFLQWIKDQRQL-L---VE-AERMECATPS---D KQGMPV------------------------------------------------------ -----------LSL-NITCQM-------NKTI-IGVSVFSVLVVSVVAVLVYKFYF---- --HL----MLLAGCINYG-------RG-------ENIYDAFVIY--SS---------QD- --EDWVRNELVKNLE-E---GVPPFQLCLHYRDFIPGVAIAAN-------IIHEGFH-KS RKVIVVVSQHFI-QSRWCIFEYEIAQTWQFLSSRAGIIF-IVLQKVEK-TLLRQQVELYR LLSRN-TYLEWEDSVLG---QHIFWRRLRKALLDGRSWNPE-TVGTGCN----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000004036 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------MSHRMGLL---- -WCVM------------------------------SLYFYGILQSHASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKE--TCFN SSMK-LPVQKLYLEYGIQK----ITCPNVDGF---------------------------F PPSVKPTVTWYMGCRKIEDFHNVVP---------EGMNLSFLIALVSN------------ ------------------------------------------------------------ --------NGDYTCVVTYPENGR-----TFHLSRT------------------------- ------------------------------------------LTVKVV--G------SPK DALP-PQIHSPNDLVDYEKEPGEELLIPCKVFFT------FLKDSRNEIWWTIDGKKPDD TTLDVTVNESVSQ--TLTEDEWRTQILSIKKVTAEDLK---------RNYVCHARN---A KGEVDK------------------------------------------------------ -----------PAKVKQKVIAPR----YTVEL-ACGFGATVLLVVILIVIYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEH--PH--PSIL-Q LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHAQ RRRSRLKDPPELQSSGRAA---GAS-PAPGTMSKHRGKSSAACRCCVTYCEGESHLRSKS RAEIHTQPQWETHLCKPVSQESETQWIQNGTRLEPPAPQISALALHHFTDLSNNNDFYIL ------------------------- >D_melanogaster_FBpp0080080 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MLTYLPVVWLFFALLVLRSATGQIIPLPTF----CLGLSPQCT CAAEGNVVRFHCP--DEYAMLLEVSEPG--ASLYMSYYASTELQWLP-RFNISSLVKIEF DAYIFWPEKFLSDLLKTLGVQTVK---------------------------TIIFRDRTL ETVVTRDVLNSG-NGY-----------------------METSQPENI--TTWHFGSVPG LKKFK--FFSHV--PELQESIFHGF----------DTLRDLHLSVN-------------- ---VTTLPGN---------------MLST-VN-------GTLKTLTIE-SPGIVSFGNPL LRELQQLRNLSLA------L--IHPFHERDKQLQ-------------------------- --------------------------------------PHFFGSMTNLEEVRL-A-SATS SVNRSMFKGTNK--LQLIK-MNGNDD-LMEL----------------------PGEI--- -FLDQVNLKTLDLSCNAI-VTLHEDV-----------------------FKGLGNLTLLD LSKN------------------------RLTNLSSTIFAPL------------------T SLNVLRLNKNSLTAMSPSVF-QDVV----------------------------------- ------------------------------------------------------------ --------------------------------------------------SLNYIEMVN- -------------------------------------------TQFYGAT---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LLMNYEAVVC--------- ----------------------------------------TNDEACQY-----------K ----SAEWQCDPRCICWVQRSVG---SLIVDCRGT--SLEE-LPD--LPRTTL------- ------------------LS-----TV---------------LKVGNNSLT------SLP TVS---EHSGYANVSGLFLSDNNLTSLGSGDQLP---DNLTHLDVRGNQIQSLSDEFLLF LQEPNNTMTLSLS--GNPITCGCESLSLLFFVRTNPQR-V---RDIADIVCTKQKK---S FQQMEA------------------------------------------------------ -----------FELCPS---Y-------VLLI-SCVVGGLVIVICLLTVFYLMFQQELKI WLYNNNLCLWWVS-EEEL-------DK-------DKTYDAFISY--SH---------KD- --EELISK-LLPKLE-S---GPHPFRLCLHDRDWLVGDCIPEQ-------IV-RTVD-DS KRVIIVLSQHFI-DSVWARMEFRIAYQATLQDKRKRIII-ILYRELEH--MNGIDSELRA YLKLN-TYLKW-----G---DPLFWSKLYYAMPHNRRVLKGQKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------HAGPLI--- >C_familiaris_ENSCAFP00000015327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSFPAPRSRSRKPVGKVADWF RQVLSK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TSKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LSDSTESTSSDVSQPRSKDN----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PPPLGLSSAVSPNSPSTYVGA-------SSSSGSSGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQE-LVSYLE-G---SAASLRCFLQLRDSTPGGAIVSE-------LC-HALS-SS HCRVLLITPGFL-QDPWCKYQMLQALSEAPGAEGRTI---PLMSGLTR-------AAYPA ELRFM-YFVDGRGPDGG-------FHQVKEAVMRCKLLEGERKSGSATAADLL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >T_guttata_ENSTGUP00000005325 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SCD-GSQLCNCSSMG LDFIP---PGVT-----------------------AKITVLNLAHNRIKRIQSQDLQQAV NLRALLLQSN---------------KISS-IDEDSFWSLEKLELLDLS-NNSLAHLSPVW FGHLFSLQHLHLEGNSYRD----------------------------------------- -----------------------------------LGQSSPFSSLKNLSSLHLGN-PQFS VIRHGNFEGIEL--LHKLW-ID-GSN-LSQY----------------------EQGS--- -LKSIKQINHMILNLRN-----GYIFSEI--------------------VRDLLH-SVTW LEVR-----RIA--FSIAAEM-QVLRVMSSSFAKKISFRQT-LLTDATVPEIVSILEDMP QLVELELVDCRLLGTGQW--KMEIQAKKSQT----------------------------- ------------------------------------------------------------ ---------------------------------------------------LRILTIKK- ------------------------------------------------------------ -----------LSI---EEFYLFTDLHSV--------EGLLSL-LTRVTVQNTKVFLVPC RISQ-NLLSLVYLDLSANL----LGDLSLEH------------------S--ACQ--G-G WPSLQALNLSQNSLSDLERTSKSLS---------HLGNLIVLDISQNNFG---------- ------------------------------------------------------------ --------EIPDV--CDWPKSLK-----YLNLSST--QI-PKVTTC-IPQTLE------- -----------------------------------------VLDVSGNNLK------EFG L--------RLPLLKELYLTRNQLKTLPGAAPI----PNLVSLSVSRNKLNSFSK---EE FESFRRMKLLDAS--GNNFICSCEFLSFIHHEAGISQV-L---VGWPDKYVCDSPL---A VRGAQV------------------------------------------------------ -----------GAVHLSLMECHR-----SLVV-SLICVLVFLVILLLVAVGYKYHM---V W-YLRMTWAWLQAKRKPK---RAP-PK-------DVCYDAFVSY--SE---------ND- --SDWVENTMVRELE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KS RKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIQSKAIPKRFCKLRK IMNTK-TYLEWPLEEEQ---QQMFWFNLKIALRS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000010774 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPRSRPKKPLGKMADWF RQALQK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPAK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MPGSPESAPSDSPRTPSQAG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PAPSGLSASTSPAPPAAHEGA------CSDSGTGSGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SRDYDVCVCH--SE---------ED- --LAAAQE-LVSYLE-G---SAASLRCFLQLRDAAPGGAIVSE-------LC-QALS-SS HCRVLLITPGFL-RDPWCRYQMLQALSEAPGAEGRTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGPDGG-------FRQVREAVLHYLRTLG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000029040 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QQLDLSKNSIRHVGKTDLQNCV NLKALMLQAN---------------QIGT-IDEDAFLSLGILELLDLS-KNRLSSLSPSW FQSLSSLLSLNLL----------------------------------------------- ------------------------------------------------------------ ------------------------------Y----------------------QPHS--- -LQSTQNINHLLLNVTK-----SDIVLKI--------------------LSDLTS-S--- -KPR-----NI-----------SMSIPVASPQLKRIELRHV-EMTDSWRLEDSRHL---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QLKR-SFELLEYLDLSGNI----LFDELLKN------------------S--ACD--G-A WPSLQTLNLSQNSLRYVDQTGASLS---------TLKKLINLDISQN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------NNNNLK------DFI L--------NLPRLKELYLSKNKLKTLPEGRLY----PNLLVMRISKNALNVFSR---KE FESFQKLKALEVG--GNNFICSCVFLTFLQDQQAIASV-L---TDWPENYICDSPS---H VRGQRV------------------------------------------------------ -----------QDTHLPLFECHR-----ALLV-SVICCILFLIIILTVALCHHFHG---I W-YMKMTWAWLQAKRKPR---KTQ-NK-------EIYFDAFVSY--SE---------ED- --SYWVENLMVQELE-H---SNPPFRLCLHKRDFVPGKWIIDN-------II-DSIE-KS HKTLFVLSENFV-KSEWCKYELDFSHFRLFDENNDSAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLKWPSDETE---RETFWLNLKSAIKTEHFIEDSRIAKESA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000051260 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSSGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMR-LPVHRLYIEQGIHN----ITCPNVDGY---------------------------F PSSVKPSVTWYKGCTEIVNFHNVQP---------KGMNLSFFIPLVSN------------ ------------------------------------------------------------ --------NGNYTCVVTYLENGR-----LFHLTRT------------------------- ------------------------------------------MTVKVV--G------SPK DAVP-PHIYSPNDRVVYEKEPGEELVIPCKVYFS------FIMDSHNEIWWTIDGKKPDD VPVDITINESVSY--SSTEDETRTQILSIKKVTPEDLK---------RNYVCHARN---A EGEAEQ------------------------------------------------------ -----------AAKVKQKVIPPR----YTVEL-ACGFGATVFLVVVLIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEQ--PH--PGIM-Q LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQ -RRSRLKEPPELQSSERVS---GAA-PAPGTISKHRGKPSAACRCCVTYCEGESHLRSKS RAEMHTHPQWETHLCKPDLQESESQWIQNGTRPE-PAPQISALALRHFTDLSNNNDFYIL ------------------------- >E_caballus_ENSECAP00000015544 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------ALWTVWVLGAVI------------------------------------ -------------S--LSKE----------------GVPDQPSSLSCD-PTGVCDGRSRS LNSIP---SGLT-----------------------AAVKSLDLSNNKIASVGNSDLWKCV NLKALRLGSN---------------DINT-IEEDSFSSLRSLEHLDLS-NNHLSNLSSSW FRPLSSLKFLNLLGSTYKT----------------------------------------- -----------------------------------LGETSLFSHLTNLRILKVGNIH-FT EIQGKDFAGLTF--LEELE-ID-ATN-LQRY----------------------EPKS--- -FKSIQNISHLILRMKQ-----PVLLPEI--------------------ILDTLS-SLEY LELR-----DTY--LNTFHFA-EVSDPETNTLIKKFTFRNV-KITDESFDEIVKLLNYIS GVSEAEFDECTLDGLGEF-RTPDIDKIKVIG----------------------------- ------------------------------------------------------------ --------------------------------------------------KLETLTIRR- ------------------------------------------------------------ -----------LRI---PQFYLFRDLSSI--------YSLTER-VKRITIENSKVFLVPC SLSR-HLKSLEYLDLSDNL----MVEEYLKN------------------S--ACE--R-A WPSLQTLILRQNHLTSLGKTGETLL---------TLKNLTKLDISKNSFH---------- ------------------------------------------------------------ --------SMPET--CQWPEKMK-----YLNLSSI--RI-DRLTQC-IPQTLE------- -----------------------------------------VLDISNNNLN------SFS L--------ILPQVKELYISRNKLKTLPDASFL----PMLLVMRISRNTINTFSK---EQ LDSFQKLKTLEAG--GNNFICSCEFLSFTQEEQALDQI-L---IDWPENYLCDSPS---H VRGQRV------------------------------------------------------ -----------QDTRLSVSECHR-----TALV-SAVCCALFLSILLTGVLCHHFHG---L W-YMKMMWAWLQAKRKPR---TAP-QR-------DICYDAFVSY--SE---------RD- --SYWVENLMVQELE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIDKKAIPQRFCKLRK IMNTK-TYLEWPTDEAQ---QEGFWLNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000015503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SKA FSMVP---PDLT-----------------------GNVLRLDLSFNRIEQVREADLKSAV NLRMLLLQSN---------------LIQT-IEEDAFHTLTRLEHLDLS-RNKLTHLSSSW FGSLSSLLTLNIKGNCYSE----------------------------------------- -----------------------------------LGENPLFSGLKSLRSLYLGNDDHFS ALRTHDLEGISV--LEELE-LV-GPK-LKQY----------------------EPRS--- -LPSTVLINNLILNDPS-----RITLLML--------------------MRDVRD-NVIS LELR-----NIQ---NVGQLH-HLSLD--DIPAQKLVFRNI-TVSDHDVVLFIRFLATVS RLHHLEVLDSHLQGHGIF-SGIQ----DISN----------------------------- ------------------------------------------------------------ --------------------------------------------------TLDVIVIRN- ------------------------------------------------------------ -----------VLI---KEFYMFSDMSSV--------LHFLEN-VTSLTIENVKVYMVNC ILGR-HCRSMQYLDLTNNL----LLDTTLIN------------------S--FCQ--D-A WPKLQTLNVSQNALKQIEIVSRSTA---------SIINLSNLDISRNTYE---------- ------------------------------------------------------------ --------AMPDF--CEWPKKLK-----YLNISSS--KV-SKVTNC-IPQSLE------- -----------------------------------------VLDVSNNNLQ------DFR L--------SLPHLQELYIQNNKLTALPPPAFS----PSIRVMNIRGNKIFGFSE---QE LETFANLEMLDAR--YNSFQCTCEFLSFMQSQSEIPHI-F---IDWPNNYICDAPE---Y VRGKEV------------------------------------------------------ -----------GIAHLYLIDCHS-----TSVV-SLICILLLLIILMVAILCYKLHA---I W-YMNMIWAWLQAKRKPR---RAR-VR-------KIDYDAFVSY--SV---------QN- --SEWVENVMVRELE-Q---AHPPFKLCLHKRDFLPGKWIVDN-------II-DSIE-RS SKTLFVLSQHFV-QSEWCKYELDFSHFRLFDENNDSAIL-ILLEPIPAETVPRRFCKLRK LMNTK-TYLEWPSDEDQ---KSIFWFNLKTAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000260010 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------TLWMVWVLGVII------------------------------------ -------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCV NLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW FKPLSSLTFLNLLGNPYKT----------------------------------------- -----------------------------------LGETSLFSHLTKLQILRVGNMDTFT KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS--- -LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDVTS-SVEC LELR-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQIS GLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETLTIRR- ------------------------------------------------------------ -----------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC LLSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-A WPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNIDISKNSFH---------- ------------------------------------------------------------ --------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- -----------------------------------------ILDVSNNNLN------LFS L--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNAITTFSK---EQ LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---H VRGQQV------------------------------------------------------ -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000003012 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------TLWMVWVLGVII------------------------------------ -------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCV NLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW FKPLSSLTFLNLLGNPYKT----------------------------------------- -----------------------------------LGETSLFSHLTKLQILRVGNMDTFT KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS--- -LKSIQNVSHLILHMKQ-----HXLLLEI--------------------FVDVTS-SVEC LELX-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQIS GLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETLTIRR- ------------------------------------------------------------ -----------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC LLSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-A WPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNVDISKNSFH---------- ------------------------------------------------------------ --------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- -----------------------------------------ILDVSNNNLN------LFS L--------NLPQLKELYISRNKLMTLPDASLL----PXLLVLKISRNAITTFSK---EQ LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---H VRGQQV------------------------------------------------------ -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000016910 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------TLWMVWVLGVII------------------------------------ -------------S--LSKE----------------ESSSQ--ALSCD-RNGICKGSSGS LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCV NLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW FKTLSSLTFLNLLGNPYKT----------------------------------------- -----------------------------------LGETSLFSHLTKLRMLRVGNMDTFT KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS--- -LKSIQNVSHLILHMKQ-----HTLLLEI--------------------FVDVTS-SVEC LELQ-----DTD--LDTFHFS-ELSTGETNSLIKKFTFRNV-KITDEGLFQVMKLLNQIS GLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETLTIRR- ------------------------------------------------------------ -----------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC SLSR-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-A WPSLRTLILRQNHLASLEKTGETLL---------TLKNLTNLDISKNSFH---------- ------------------------------------------------------------ --------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- -----------------------------------------ILDVSNNNLN------LFS L--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNTITTFSK---EQ LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---H VHGQRV------------------------------------------------------ -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-SR-------DICYDAFVSY--SE---------RD- --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000028379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------TLWMVWVLGVII------------------------------------ -------------S--LSKE----------------ESSNQ-ASLSCD-RNGICKGSSGS LNSIP---SGLT-----------------------EAVKSLDLSNNRITYISNSDLQRCV NLQALVLTSN---------------GINT-IEEDSFSSLGSLEHLDLS-YNYLSNLSSSW FKPLSSLTFLNLLGNPYKT----------------------------------------- -----------------------------------LGETSLFSHLTKLQILRVGNMDTFT KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------ESKS--- -LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDVTS-SVEC LELR-----DTD--LDTFRFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLNQIS GLLELEFDDCTLNGVGNF-RASDNDRVIDPG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETLTIRR- ------------------------------------------------------------ -----------LHI---PRFYLFYDLSTL--------YSLTER-VKRITVENSKVFLVPC LLSQ-HLKSLEYLDLSENL----IVEEYLKN------------------S--ACE--D-A WPSLQTLILRQNHLASLEKTGETLL---------TLKNLTNVDISKNSFH---------- ------------------------------------------------------------ --------SMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- -----------------------------------------ILDVSNNNLN------LFS L--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNAITTFSK---EQ LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---IDWPANYLCDSPS---H VRGQQV------------------------------------------------------ -----------QDVRLSVSECHR-----TALV-SGMCCALFLLILLTGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-SR-------NICYDAFVSY--SE---------RD- --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPMDEAQ---REGFWVNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000093843 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MGLL---- -WYLM------------------------------SLSFYGILQSHASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----YNYSTA-HSSGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SAMR-FPVHKMYIEHGIHK----ITCPNVDGY---------------------------F PSSVKPSVTWYKGCTEIVDFHNVLP---------EGMNLSFFIPLVSN------------ ------------------------------------------------------------ --------NGNYTCVVTYPENGR-----LFHLTRT------------------------- ------------------------------------------VTVKVV--G------SPK DALP-PQIYSPNDRVVYEKEPGEELVIPCKVYFS------FIMDSHNEVWWTIDGKKPDD VTVDITINESVSY--SSTEDETRTQILSIKKVTPEDLR---------RNYVCHARN---T KGEAEQ------------------------------------------------------ -----------AAKVKQKVIPPR----YTVEL-ACGFGATVFLVVVLIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNV---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-KLIV-VEYRPLEQ--PH--PGIM-Q LKESV-SFVSWKGEKSK-HSGSKFWKALRLALPLRSLSAS-SGWNESCSSQSDISLDHVQ -RRSRLKEPPELRSSERVS---GAE-PAPGTMSKHRGKPSAACRCCVTYCEGESHLRSKS RAEMHTHPQWETHLCKPPLQESESQWIQNGTRPE-PAPQISALALRHFTDLSNNNDFYIL ------------------------- >M_mulatta_ENSMMUP00000020834 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPH ------------TLWMVWVLGVII------------------------------------ -------------S--LSKE----------------ESSNQ-ASLSCD-HNGICKGSSGS LNSIP---SVLT-----------------------EAVKCLDLSNNRITYISNSDLQRYV NLQALVLTSN---------------GINT-IEEDSFSSLGRLEHLDLS-YNYLSNLSSSW FKPLSSLKFLNLLGNPYKT----------------------------------------- -----------------------------------LGETSLFSHLTKLRILRVGNMDTFT KIQRKDFAGLTF--LEELE-ID-ASD-LQSY----------------------EPKS--- -LKSIQNVSHLILHMKQ-----HILLLEI--------------------FVDLTS-SVEC LELR-----DTD--LNTFHFS-ELSTGETNSLIKKFTFRNV-KITDESLFQVMKLLSQIS GLLELEFDDCTLNGVGDF-RGSDNDRVIDPG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETLTIRR- ------------------------------------------------------------ -----------LHI---PQFYSFNDLSTL--------YPLTER-VKRITVENSKVFLVPC LLSR-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--D-A WPSLQTLILRQNHLASLGKTGETLL---------TLKNLTNLDISKNTFH---------- ------------------------------------------------------------ --------YMPET--CQWPEKMK-----YLNLSST--RI-HSVTGC-IPKTLE------- -----------------------------------------ILDISNNNLN------LFS L--------NLPQLKELYISRNKLMTLPDASLL----PMLLVLKISRNTITTFSK---EQ LDSFHTLKTLEAG--GNNFICSCEFLSFTQEQQALAKV-L---ADWPANYLCDSPS---H VRGQRV------------------------------------------------------ -----------QDVRLSVSECHR-----AALV-SGMCCALFLLILLMGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-NR-------DICYDAFVSY--SE---------RD- --AYWVENLMVQELE-N---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPMDEAR---QEGFWVNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP001004-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MKASRGP RPLVLTAALTLALLAHTGHAFLAGYRSGLGLDGFGICPAEMRNCSCR----SYT------ ----GAETEIDCP--EADSTVHLRIEPHQYAEMRCQRNRRYDFEQIP-QLSIGDTNRLTI DDCPFPHHQSILQLVSFLGTTQVK---------------------------VLWLKNNAN HEQSASLVRHHF-AGLDQLD----------------RLAISNAKLSDI--GPDLFEHLPN LTWLD--MRDNI--FRLPATIFDAL----------PKLRVLELSFNSLEELDPRLLRHLP NLRLLTLWHN---------------KLRT-LSRAAFAGVPELERLDLS-SNQLESVPGDL FADLPHLTELAMGVNNFRTL--PDGLFRANRELRKVKLASQRVELE-------------- -----------------------------------TLPHDLLQMLPALDQVSLER-VGLV SLPGTLLFGSAN--LTQLN-LANN-R-LHQL----------------------PEDL--- -LRDQKALQVLQLQHNQL-TGLPAGL-----------------------LRNTVELHTLR LSHN------------------------QIGELSAVALQAL------------------T KLQELYLDHNQLYTIELHAF-KQTT----------------------------------- ------------------------------------------------------------ --------------------------------------------------ALHTLHLQV- -------------------------------------------NQLAFETLNTLPATAPD TGDQEQLTDHIPAP---DEFSLLAQDGTP--------FQHLH-QLRELDLSSNWLTAVPR DLLL-NTHELQRLNLTRNN----ITSLTYAN------------------------LQF-L APA-ITVDLRHNSIFEIDLADMERLVLLEPRNFDEQTGRARVLLNDNPLHCNCIAYAFAQ YIQNRLATAVYDRFELVANELTCHGPEHLEGALIKDVP--TRELLCEL-----------D -TPSTAIRHCPAPCRCYIRPEDT---GVIIDCSGQ--ALTE-VPE--LPRPTT------- ------------------FGYRF--IE---------------LHLENNNIS------ALP DSTTASGSSGWAEVRELYASNNSIAAL-AADQLP---RSLRLLDLSRNRLTTLDGPLAES LTASTTLTTVRLA--HNDWTCQCETTQLLTFAHANQRR-I---EDFGRLRC-SDGR---P LEQMTL------------------------------------------------------ -----------SDLCVDRTHM-------IVLT-CVIVSVVACLVAALSLVYYTYKLELKV WLFKHGLCLWLVA-EEEL-------DR-------DKLYDAFVSY--SH---------KD- --EAFITEHLVPTLE-R---DPMNFKLCWHVRDWTPGEMISSQ-------IS-SSVE-QS RRTIIVLSSSFL-ESLWGQLEFRTAHLQSMAERRNRLII-IIYGDIGN--IYDLEPELRA YLHTN-TYVRW-----G---DPWFWDKLRFAMPHPPKV-RGASG----TASTVVKSGVST AGGLFMKQLQGAAPVDDRLELIKPQVTPATPP----ALTT--------PPTEPISSATPA PGPFVISGNGGGVGGAGAQLLHQQLSNAYRASGHINGAFVINSN---------------- ----------------AKQSDV--- >M_musculus_ENSMUSP00000029623 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MLR ------------ALWLFWILVAIT------------------------------------ -------------V--LFSK----------------RCSAQ-ESLSCD-ASGVCDGRSRS FTSIP---SGLT-----------------------AAMKSLDLSFNKITYIGHGDLRACA NLQVLMLKSS---------------RINT-IEGDAFYSLGSLEHLDLS-DNHLSSLSSSW FGPLSSLKYLNLMGNPYQT----------------------------------------- -----------------------------------LGVTSLFPNLTNLQTLRIGNVETFS EIRRIDFAGLTS--LNELE-IK-ALS-LRNY----------------------QSQS--- -LKSIRDIHHLTLHLSE-----SAFLLEI--------------------FADILS-SVRY LELR-----DTN--LARFQFS-PLPVDEVSSPMKKLAFRGS-VLTDESFNELLKLLRYIL ELSEVEFDDCTLNGLGDF-NPSESDVVSELG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETVTIRR- ------------------------------------------------------------ -----------LHI---PQFYLFYDLSTV--------YSLLEK-VKRITVENSKVFLVPC SFSQ-HLKSLEFLDLSENL----MVEEYLKN------------------S--ACK--G-A WPSLQTLVLSQNHLRSMQKTGEILL---------TLKNLTSLDISRNTFH---------- ------------------------------------------------------------ --------PMPDS--CQWPEKMR-----FLNLSST--GI-RVVKTC-IPQTLE------- -----------------------------------------VLDVSNNNLD------SFS L--------FLPRLQELYISRNKLKTLPDASLF----PVLLVMKIRENAVSTFSK---DQ LGSFPKLETLEAG--DNHFVCSCELLSFTMETPALAQI-L---VDWPDSYLCDSPP---R LHGHRL------------------------------------------------------ -----------QDARPSVLECHQ-----AALV-SGVCCALLLLILLVGALCHHFHG---L W-YLRMMWAWLQAKRKPK---KAP-CR-------DVCYDAFVSY--SE---------QD- --SHWVENLMVQQLE-N---SDPPFKLCLHKRDFVPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-RSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIERKAIPQRFCKLRK IMNTK-TYLEWPLDEGQ---QEVFWVNLRTAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000013025 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MLQ ------------ALWLFWILMAVI------------------------------------ -------------G--LSRE----------------GHSAQ-ASLSCD-AAGVCDGSSRS FTSIP---SGLT-----------------------ANTKKLDLSFNKITYIGHGDLRACV NLRVLTLESS---------------GINT-IEGDAFYSLGSLEHLDLS-NNHLSSLSSSW FRPLSSLKYLNLMGNPYRT----------------------------------------- -----------------------------------LGETSLFSNLTNLQNLRVGNVDTFS EIRRIDFAGLTS--LNELE-IQ-VLS-LGNY----------------------ESRS--- -LQSIRDIYHLTLHLSE-----SAFLLGI--------------------FADILS-SVRY LELR-----DTN--LARFQFS-ELSVDEINSPMKKLAFRNA-DLTDKSFNELLKLLRYIL ELMEVEFDHCTLNGVGNF-NPSESDVVRELG----------------------------- ------------------------------------------------------------ --------------------------------------------------KVETVTIRS- ------------------------------------------------------------ -----------LHI---PQFYLFYDLSTV--------YSLLEK-VKRITVENSKVFLVPC SFSQ-HLKSLEFLDLSENL----MVEEYLKN------------------S--ACE--G-G WPSLQSLVLSQNHLRSIRKTAEILL---------TLKNLTALDISKNSFQ---------- ------------------------------------------------------------ --------PMPDS--CQWPGKMR-----FLNLSST--GI-QAVKTC-IPQTLE------- -----------------------------------------VLDVSNNNLD------SFS L--------FLPRLQELYISRNKLKTLPEASLF----PVLQVMKIRENAISTFSK---DQ LGSFPKLETLEAG--DNHFICSCELLSFILERPALVHV-L---VDWPDSYLCDSPP---R LHGQRL------------------------------------------------------ -----------QDARPSVLECHQ-----AALV-SGVCCALLLLILLLGALCYHFHG---L W-YLRMMWAWLRAKRKPK---KAP-CR-------DLCYDAFVSY--SE---------QD- --SYWVENLMVQQLE-N---SDPPFKLCLHKRDFVPGKWIIDN-------II-DSIE-KS HKTVFVLSENFV-RSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPLDEGQ---REVFWANLRTAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_aegypti_AAEL007613-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MARALPLLALLLTHNLASSFP QHHYTDYVLGGELVSGGGAGGTTTGIGSSGTGGTGTGAGEQRFTCPE----PTTTTSDCT CMYASSDYEIQCP--VINPEITVKIKPGIYAQIQCY--EKQEFSDLP-TLNVGNTTQVKI IHCPLPQRQSIKQFIKFLGVNHVK---------------------------DFWYQNYG- KDFGVRLIRQHF-EGMHDLE----------------KLFLSSG-IEDI--QPDLFADLPN LKWLI--LRSNH--VKLLHNVFDNL----------TNLIILELGANQITELEPGLFKNQR KLRHLNLWRN---------------QLRN-ISKESFRGAETLQELDLS-VNAIETLNSDV FTLLPDLTVLNLGFNRFTVL--PDNLLSENRKLREFKFINNQAPLQ-------------- -----------------------------------TLPEAFLGNLPQLKSVILNR-CSFT HLPASLFRGSSE--ITHMD-LSYN-Q-LGSV----------------------PELL--- -LRDQLRLQDLNLAYNEL-ESLPEHL-----------------------LENTRELLTLR LSYN------------------------RLYNLSANIFASL------------------D KLTELHLNDNFLHAIDRLTF-SNTK----------------------------------- ------------------------------------------------------------ --------------------------------------------------ALGKLYMQN- -------------------------------------------NHLSFHDFS-------- -----------FVL---QEQDIADTDGTP--------FQYLE-NLQILNLRNNSITTIFR DWNY-NNLHLRELDLSYNN----ISTLSYLS------------------------LQF-L SQD-VRVNLTHNRISEIDLKDMEPI---ITSQRSQDDSKIYVYVNDNPLNCNCVIFSFVQ YLLNELDSAVYRRIQFVADDLRCSEPQNLEGVHVSKLQ--TKDLLCQL-----------D -QPGTEIKHCPANCSCHVRPLDR---GVIVNCTRQ--GLTE-IPA--LPQPTM------- ------------------FGYNF--IE---------------LHVEDNNIT------ELP TEN----LTGYGKVAELYARNNAIVEL-LPENLP---SSLRILDVTQNKFVMLNQSVVES LNSSKVLESLHLS--GNKWRCDCSSAQFMNFVQQNHKK-I---ADLGQITC-ETGE---E FSLITV------------------------------------------------------ -----------NSLCNESVTT-------VITI-SVILSILGLLIGLFTVLYFVYHMEIKV WLFTHNMCLWWVS-EEEL-------DK-------DKLYDAFISY--SH---------KD- --EEFITEHLVPTLE-K---EPMNFKTCWHVRDWMPGELIPTQ-------IA-KSVE-DS RRTIVVLSTNFL-ESVWGRMEFRTAHLTSMEEKRARVIV-IIYGDIGS--IEDLDPELKA YLKMN-TYVKW-----G---DQWFWDKLRYAMPHPPTV-KGLKGKGLIKNHLKSSV---- ---------------DDKLELIKPVPVTPPPL----TTPP--------AEMNGHARSPPF TISNGKVVNGNGYHINGHVM-------NGHVNGHINGAFVINSN---------------- ----------------AKQSDV--- >D_melanogaster_FBpp0079369 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MEHSKLWDLRPEVRERRFKWTSDGQQQQQQQLGWCNNKDDPPNSHQK SKSNNDARNLNSRVRVRARVRVVPGEMRMGDINCSNGLGNIREDYCEIYLDELGENGTCS IANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKICNETDYELVI-------ISVLGI RSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMVTFKYLYDSTVN SVITNNYIRKTM-NNTEKIK----------------IYYHNTFEKTTLTMEKNIFHGKNK MSALI--FNGLK-IKGLTNNTFENL----------TSLNTLIFDNVFLKDL--SFLRSST LQSSLTYCIM---------------KVDNMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFI CEPYKSHCKFTLGINEVACP--LKCNCSYNRDKSQLEIDCWQKNLT-------------- -----------------------------------TIPS-LPVPKKGSSALVFQS-NLLA ELPDNSLEGYHN--LKSLD-VSYN-Q-LTSL----------------------SVSQ--- -LPES--LHYLDIRHNKI-TTLSPQV-----------------------VEYLYSVNVFN QYGN-----KWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQ NIDQLYLEANEDEIIDAFGPSDKYF----------------------------------- ------------------------------------------------------------ --------------------------------------------------NLKLMEALN- -------------------------------------------HAIWLFSGE-------- -----------------FDEIILHHLNSPCPYRCSCCFEWHT-GEFLINCRNLSLD-IYP RLPN-SIPYKTTLYLDRNE----IRKLTNTESLVVAGHASIHKLHMSQNLLRELPLHL-L PENITYLDVRNNLLKYLDDGVIAFL--------EYRENITKIELSGNPWECNCKAKAFLS FLRR-------------------HEPMEYETVLRRVEI--TDD----------------- --------KCPEDCICCVDTSNSDSLAYVVDCSGK--ELSE-IPQ--LPTPT-------- ----------------------YGQTT---------------LVFERNSLK------KWP SSL----LPGYSSVTRFYLAHNRLSDI---DQLP---DKLEYLDISNNNFSALDDRVRGF LQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKN-I---ANASAIQCIDTGR---S LIEVEE------------------------------------------------------ -----------TDICPSVLIY-------YTSL-AVSL----LIIALSINVFICFRQPIMI WFYEHEICLSLAA-RREL-------DE-------DKKYDAFLSF--TH---------KD- --EDLI-EEFVDRLE-N---GRHKFRLCFYLRDWLVGESIPDC-------IN-QSVK-GS RRIIILMTKNFL-KSTWGRLEFRLALHATSRDRCKRLIV-VLYPDVEH--FDDLDSELRA YMVLN-TYLDR-----N---NPNFWNKLMYSMPHASHL-KRSRS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------DAETKV--- >D_rerio_ENSDARP00000015475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MLV P---------------LVLILSLQ------------------------------------ -------------AVLHIKH----------------AKAKQSCTIAF--DKLSADCKGLR LDSVP--TTQLP-----------------------DSLEELDLSFNTIHVIRKQDFVKLT YLRVLKLNFN---------------NISL-VLDDAFQGNLLLEELNLF-NNSLTEIPFKA LEPLTNLKVLEMSNNLYSQ----------------------------------------- -----------------------------------ASLGAAFLNFNQLKVLSIGG-PLVS SLGSRDIYVLKNISLDKFA-VKTGTG-FRDY----------------------EPGY--- -FKSL-STKHLWFDIAF--DKNPDLLPKM--------------------LKDLANKTFDV LRFR-----NLFEFQYYTGKR-DIFYGLQYVNAQTLTFYRG-KFNEEVMRMALKNVEI-S PIKALELLLIDFARSQ---NRTQGSS-VKNL----------------------------- ------------------------------------------------------------ --------------------------------------------------SLDRLVLSD- ------------------------------------------------------------ -----------ISN---PDIMRF---DWS--------FTWLNH-VRKFIVWNVNFNSVPC DSWP-EMKSVELLDISNNQ----LLDSYIYN------------------P--LCDTRN-T LHKLDTFNVSHNRLTSLSDLASLTK---------DFVKLTTIDMSHNQLQ---------- ------------------------------------------------------------ --------YLGNGA-CDWRKTIT-----KVIGNHN--SLTSDSFKC-LPTSVN------- -----------------------------------------FLDLSYSSLD------QLD MDY----FNKASELTELLLSGNKIKFIPSGWKN----RYLRTLALDGNSFGLVSM---KS FKDMLSLRVLTAG--NNPYHCTCDLYTFIQETTSKGKVTI---TDWPNNYKCYHPE---R LLNTMV------------------------------------------------------ -----------SKYSPGHLACDI-----TLVI-IISVSTTAAVVLVIMLLCYIFHV---P W-YVKATYQIIRAKYRAHKE-GLGQGV-------DYAFHAFISY--SH---------SD- --ADWVRNHLLPCLE-N---VKPPYRLCIHERDFIPGKWIIDN-------II-ENIE-NS RKVIFVLSHNFV-NSEWCNYELYFAQQRAIGKTFSDVIL-VVKEPIDPTSLPSKFCKLKR MLNTK-TYLEWPQQPTE---QNFFWIQLRSVLGKPNSIRPRTISRHSRLSSARSVSLIEA PQIQDPEGPDEEDHQNSPQPSNKCQLTCIEVA---------------------------- ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000007049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MGIR---- -WKLT------------------------------NIVSYFSLM--VQERCEDWGLDTMT KIQVYDGEPA---------------CIKCPLFEQFLK-----YNYSTA-HSAGLTLIWYW IGQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PDNRISKEKDIL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVRKDPGKCVS PLVK-PLVKLLYEEEDLQF----INCPNIDGF---------------------------Y PVNLKPVVHWFKGCKEVNNFHSVFP---------NGTSLDFTTARSSI------------ ------------------------------------------------------------ --------NGIYTCIVNYLDGGR-----TFSLTRS------------------------- ------------------------------------------VEVKVV--G------HPD KALP-PQMLSPMDQVVYEKEPGEELLLPCEVIFT------FLKDSPKEIWWTIDGKKTDD IP-DITVNQSIIT--SQIEDITIKKTLNIKKVSSDDLK---------RNYTCHARN---A KGKVEK------------------------------------------------------ -----------QAKVKQKVLVPR----YTVEL-ACGFGATVFLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGNTVEA-------VF-DFIQ-RS RRMIVVLSPDYVTEKSISMLEFKLGVMCQNSIAT-QLIV-VEYQPLQH--PH--PGVL-Q LKESV-PFISWKGEKSN-KPGSQFWKALRLALPLRSLNAG-SGWNDSCSSQSDLSLDHIQ RRRSRLKAPSERQDSKSGL---STV-PTPMARAKHRAKPSSACRCCVTYCGGQSQLRSKS RAEVQVQPQWETHLCKPVPRHSETHWIQNGNKAEVPAPQISSLALHHFTDLSNNNDFYVL ------------------------- >A_aegypti_AAEL003507-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MQGLE----------------KLFLSAG-IDYI--QQDLFADLRN LKWLV--LQGNN--LTRLGNVFDSL----------IDLVILELGANQISDLQAGFLQKQS KLRHLNLWHN---------------EIRK-VSKDMFRGAESLEELDLS-VNLIKYLEPDV FDELPLLSTLNLGFNQLQNI--PKGLLSSNHLMKEFRMINNQGQMD-------------- -----------------------------------VLPDELFGNLPNLITLILSR-NKFS EIPSSLFIGSSA--IQHID-FSYN-N-LRHL----------------------PEQL--- -LRDQHWLQHLNVANNRL-EVIPDEL-----------------------LENTSELTFLD FSFN------------------------RLQNISAKAFASL------------------D KLIELHLENNGILEIDLFAF-SAAG----------------------------------- ------------------------------------------------------------ --------------------------------------------------NLQSLFLQN- -------------------------------------------NHLQYED---------- -----------------------STDKSP--------FQYLN-NLRVLNLKNNSISAILH DWNY-NALQLHELDLSNNK----FTRLTYLN------------------------LHF-I SRD-IRIDLTHNGISRVDMSGFRIP---SASKQPRKTGKIWVNLNANPLDCSCSALSFVQ YIQD--PSSSIRRIQFSTRELHCLTPENLNGTKVSIVP--LADLTCQL-----------D -QP-----RCPKECHCFQRPIDL---TVVVNCTSR--GLIR-IPQ--LPYPET------- ------------------FGYSS--IE---------------LHIDNNSIN------ELP TEG----LSA---VSMLFARNNFISQL---HNLP---SNLRVLDVSQNRLTTLDAITIQA LNGSLPLERLLLG--SNPWQCDCSSAPFLDFVQQTYQL-I---ADTIHITC-PNGQ---R LVAISV------------------------------------------------------ -----------VELCKERWIM-------VVAV-SLSILVLGLFVGISTAVCFAYHNEIKI WLFKRNLLMCWVT-EQEV-------DK-------DKQFDAFISY--SH---------HD- --EDFVANHLVPTLE-Q---PPMNFRTCWHVRDWTPGELITEQ-------MT-RSIS-ES RRTIVVLSKGFL-ESVWARMEFRTAHLNSIAERRSRVIV-ILYEHFGD--IEQLDADLKA YLRTN-TYIRW-----G---DPWFWDRLQYAMPHAPRI-RGVKELRCARSYELGML---- ---------------EDQMEMSKSQIIAYDAF-------------------RGYL-NPTL SRSIGRSLE----EFDG--------------DGNFEGVDTLDSRCFDELII--------- --------------IITKESEV--- >G_gallus_ENSGALP00000015018 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MFN Q---SKQKPTMKLMWQAWLIYTAL------------------------------------ -------------AAHLPEE----------------QALRQ-ACLSCD-ATQSCNCSFMG LDFIP---PGLT-----------------------GKITVLNLAHNRIKLIRTHDLQKAV NLRTLLLQSN---------------QISS-IDEDSFGSQGKLELLDLS-NNSLAHLSPVW FGPLFSLQHLRIQGNSYSD----------------------------------------- -----------------------------------LGESSPFSSLRNLSSLHLGN-PQFS IIRQGNFEGIVF--LNTLR-ID-GDN-LSQY----------------------EPGS--- -LKSIRKINHMIISIRR-----IDVFSAV--------------------IRDLLH-SAIW LEVR-----EIK--LDIENEK-LVQNSTLPLTIQKLTFTGA-SFTDKYISQIAVLLKEIR SLRELEAIDCVLEGKGAW-DMTEIARSKQSS----------------------------- ------------------------------------------------------------ ---------------------------------------------------IETLSITN- ------------------------------------------------------------ -----------MTI---LDFYLFFDLEGI--------ETQVGK-LKRLSIASSKVFMVPC RLAR-YFSSLLYLDFHDNL----LVNNRLGE------------------T--ICE--D-A WPSLQTLNLSKNSLKSLKQAARYIS---------NLHKLINLDISENNFG---------- ------------------------------------------------------------ --------EIPDM--CEWPENLK-----YLNLSST--QI-PKLTTC-IPSTLE------- -----------------------------------------VLDVSANNLQ------DFG L--------QLPFLKELYLTKNHLKTLPEATDI----PNLVAMSISRNKLNSFSK---EE FESFKQMELLDAS--ANNFICSCEFLSFIHHEAGIAQV-L---VGWPESYICDSPL---T VRGAQV------------------------------------------------------ -----------GSVQLSLMECHR-----SLLV-SLICTLVFLFILILVVVGYKYHA---V W-YMRMTWAWLQAKRKPK---RAP-TK-------DICYDAFVSY--SE---------ND- --SNWVENIMVQQLE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KS HKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDVAIL-ILLEPIQSQAIPKRFCKLRK IMNTK-TYLEWPPDEEQ---QQMFWENLKAALKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >C_familiaris_ENSCAFP00000012269 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MSR ------------VLWTLWVLGAVT------------------------------------ -------------N--LSKE----------------EAPDQSSSLSCD-PTGVCDGRSRS LNSMP---SGLT-----------------------AAVRSLDLSNNEITYIGNSDLRDCV NLKALRLESN---------------GINT-IEEESFFSLWSLEHLDLS-YNLLSNLSSSW FRPLSSLKFLNLLGNPYKS----------------------------------------- -----------------------------------LGETPLFSQLTNLRILKVGNIYSFT EIQDKDFAGLTF--LEELE-ID-ASN-LQRY----------------------EPKS--- -LKSIQNISYLALRMKQ-----PVLLVEI--------------------FVDLSS-SLKH LELR-----DTH--LDTFHFS-EASINETHTLVKKWTFRNV-KVTDRSFTEVVRLLNYVS GVLEVEFEDCTLYGLGDF-DIPDVDKIKNIG----------------------------- ------------------------------------------------------------ --------------------------------------------------QIETLTVRR- ------------------------------------------------------------ -----------LHI---PHFYSFYDMSSI--------YSLTED-VKRITVESSKVFLVPC SLSQ-HLKSLEYLDLSDNL----MVEEYLRN------------------S--ACQ--H-A WPLLQTLILRQNRLKSLEKTGETLL---------TLKNLVNLDISKNNYL---------- ------------------------------------------------------------ --------SMPET--CQWPEKLK-----CLNLSDT--RM-QSITRC-IPQTLE------- -----------------------------------------ILDVSNNNLE------SFS L--------ILPQLKELSISRNKLKTLPDASFL----PTLQIMRISRNTINAFSK---EQ LDSFHRLQTLEAG--GNNFLCSCEFLSFTQEQQALAGL-L---VGWPEDYLCHSPS---Y VRGQRV------------------------------------------------------ -----------GTARLPASECHR-----TALV-AAVCCVLLLLVLLTAGACHHFHG---L W-YLRMLWAWLQAKRKPR---KAP-SR-------DVCYDAFVSY--SE---------HD- --SYWVENLLVQKLE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIEKKAIPQRFCKLRK IMNTK-TYLEWPTDDAQ---QEGFWLNLRTAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000015020 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MHT --------------WKMWAICTAL------------------------------------ -------------AAYLPEE----------------QALRQ-ACLSCD-ATQSCNCSFMG LDFIP---PGLT-----------------------GKITVLNLAHNRIKVIRTHDLQKAV NLRTLLLQSN---------------QISS-IDEDSFGSQGKLELLDLS-NNSLAHLSPVW FGPLFSLQHLRIQGNSYSD----------------------------------------- -----------------------------------LGESSPFSSLRNLSSLHLGN-PQFS IIRQGNFEGIVF--LNTLR-ID-GDN-LSQY----------------------EPGS--- -LKSIRKINHMIISIRR-----IDVFSAV--------------------IRDLLH-SAIW LDVR-----KLA--FSVPEKI-QLLRIMSSSFAKKISLKQC-LFTDATVPEIVSILEGMP KLMEVEMKDCTLLGTGKW--YKQIHANQSQS----------------------------- ------------------------------------------------------------ ---------------------------------------------------LRILTIEN- ------------------------------------------------------------ -----------LSI---EEFYLFTDLQSV--------LDLLSL-FRKVTVENTKVFLVPC KLSQ-HLLSLEYLDLSANL----LGDQSLEH------------------S--ACQ--G-A WPSLQTLNLSQNSLSDLKMTGKSLF---------HLRNLNLLDISENNFG---------- ------------------------------------------------------------ --------EIPDM--CEWPENLK-----YLNLSST--QI-PKLTTC-IPSTLE------- -----------------------------------------VLDVSANNLQ------DFG L--------QLPFLKELYLTKNHLKTLPEATDI----PNLVAMSISRNKLNSFSK---EE ------------------------------------------------------PL---T VRGAQV------------------------------------------------------ -----------GSVQLSLMECHR-----SLXV-SLICTLVFLFILILVVVGYKYHA---V W-YMRMTWAWLQAKRKPK---RAP-TK-------DICYDAFVSY--SE---------ND- --SNWVENIMVQQLE-Q---ACPPFRLCLHKRDFVPGKWIVDN-------II-DSIE-KS HKTLFVLSEHFV-QSEWCKYELDFSHFRLFDENNDVAIL-ILLEPIQSQAIPKRFCKLRK IMNTK-TYLEWPPDEEQ---QQMFWENLKAALKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000010530 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPR ------------ALWTAWVW-AVI------------------------------------ -------------I--LSTE----------------GASDQASSLSCD-PTGVCDGHSRS LNSIP---SGLT-----------------------AGVKSLDLSNNEITYVGNRDLQRCV NLKTLRLGAN---------------EIHT-VEEDSFFHLRNLEYLDLS-YNRLSNLSSSW FRSLYVLKFLNLLGNLYKT----------------------------------------- -----------------------------------LGETSLFSHLPNLRTLKVGNSNSFT EIHEKDFTGLTF--LEELE-IS-AQN-LQIY----------------------VPKS--- -LKSIQNISHLILHLKQ-----PILLVDI--------------------LVDIVS-SLDC FELR-----DTN--LHTFHFS-EASISEMSTSVKKLIFRNV-QFTDESFVEVVKLFNYVS GILEVEFDDCTHDGIGDF-RALSLDRIRHLG----------------------------- ------------------------------------------------------------ --------------------------------------------------NVETLTIRK- ------------------------------------------------------------ -----------LHI---PQFFLFHDLSSI--------YPLTGR-VKRVTIENSKVFLVPC LLSQ-HLKSLEYLDLSENL----MSEETLKN------------------S--ACK--D-A WPFLQTLVLRQNRLKSLEKTGELLL---------TLENLNNLDISKNNFL---------- ------------------------------------------------------------ --------SMPET--CQWPGKMK-----QLNLSST--RI-HSLTQC-LPQTLE------- -----------------------------------------ILDVSNNNLD------SFS L--------ILPQLKELYISRNKLKTLPDASFL----PVLSVMRISRNIINTFSK---EQ LDSFQQLKTLEAG--GNNFICSCDFLSFTQGQQALGRV-L---VDWPDDYRCDSPS---H VRGQRV------------------------------------------------------ -----------QDARLSLSECHR-----AAVV-SAACCALFLLLLLTGVLCHRFHG---L W-YMKMMWAWLQAKRKPR---KAP-RR-------DICYDAFVSY--SE---------RD- --SYWVENLMVQELE-H---FNPPFKLCLHKRDFIPGKWIIDN-------II-DSIE-KS HKTIFVLSENFV-KSEWCKYELDFSHFRLFDENNDAAIL-ILLEPIDKKAIPQRFCKLRK IMNTK-TYLEWPVDETQ---QEGFWLNLRAAIRS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000048303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KYT E-----KECSGHTISCTPILYC-------------------------------------- ----------------LRET----------------LWHPLTICINTNIQRRYANCQGQD LVEVP---QDLP-----------------------VTLQSLDLSYNRLFHIRYEDFSSYT NLRALNLSFN---------------NIST-IECGSFASNTLLRNLTLF-NNSLTEMPSTL FEPLLLLEFLDVSNNLYNY----------------------------------------- -----------------------------------STLGKVFENLVNLQNLAIGG-PLVS KVLKDDFAPIKNRSLKKFS-LKTMSK-LGFY----------------------EPGA--- -LEVL-NTRVLWLDISL--DTNAQALPLI--------------------LKDLAGKTIDS LRFR-----RLFESSYYTDTM-DLFCGLVDINIRELIFFRG-MFTENLLHQALHSIQK-S TIQDLLLLSVKFDRSL---NTNNTHILFDRL----------------------------- ------------------------------------------------------------ --------------------------------------------------YLNSLVIRD- ------------------------------------------------------------ -----------IAG---PHIFKY---DWT--------FTWFSK-VRNLQLSRVHLGSLPC IAWR-QMGNIECLDVSDNR----LIGSNLYN------------------P--SCWD-G-G LPKLDTFIAANNNLQSLRLISLLTA---------KWPKLTKLDLSSNDLG---------- ------------------------------------------------------------ --------VYNEV--CTWIPNIT-----TLILKGN--TLKMCVFQC-LPTSVE------- -----------------------------------------LLDLSYSQLE------QLD LNY----FNRATNLKELVLSHNKLNFISSDWRS----PNLQVLHLEGNSISLIDK---GT FKDLPSLRRLTAG--NNPYDCTCDLYAFFSTLQNNDEMLL---ADWPYDYQCFHPQ---H LRDTDV------------------------------------------------------ -----------EDYTPWRVECDV-----SLVI-TISVSTTAAIIILCMLVCWRFDV---P W-YLRMTWRIVKSKYRSK---KSNKSR-------EYNYHAFISY--SY---------SD- --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-ENIE-NS RKIIFVLSSNFI-NSEWCNYELYFAHQRAIGHSLEDIIL-VVKEKVTMEDLPKRFHKLRK MLRTK-TYLEWPSEPSK---QHFFWIQLKSIL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >B_taurus_ENSBTAP00000028660 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSSPAPGSRSKKPLGKMADWF RQALAR------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPTK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MPVSPESALSDVSHPSSPDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PPSLGSSSEVSPIPAPSHGSADGGGGSGNSGNSSGGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LAAAQE-LVSYLE-G---GAASLRCFLQLRDATPGGAIVSE-------LC-HALS-SS HCRVLLITPGFL-RDPWCRYQMLQALSEAPGAEGRTI---PLMSGLSR-------AAYPA ELRYM-YFVDGRGPEGG-------FRQVKEAVMRYLQTLG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000002918 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MPP ------------ALWTVWALGAIV------------------------------------ -------------S--LPTE----------------GAPDL-PSLSCD-PAGICDGRSRS FQSIP---SGLM-----------------------ATVKSLDLSNNEITYIRDSDLHRCV HLRALMLMSN---------------GIDT-IDEDSFSSLGSLEHLDLS-NNHLSHLSAAW FRPLSSLKFLNLLENPYRT----------------------------------------- -----------------------------------LGETSLFSHLPHLRILKVGSLYAFV NIRRMDFAGVRS--LEELE-ID-GSN-LQSY----------------------EPRG--- -LGSIPNVSRLVLHLRQ-----PTLLLKL--------------------FPDLLS-SVEC LELR-----ETD--LEDFRFS-GLSVTEPNPRITRFIFRSK-KITDESCNEILKLLAYPP HL-DLEXXXXXXXXXXXX-XXXXXXXXXXXX----------------------------- ------------------------------------------------------------ --------------------------------------------------XXXXXXXXX- ------------------------------------------------------------ -----------XXX---XXFYLFYDLSTL--------IARSER-VKRVTVENSKVFLVPC SFSQ-HLKSLEYLDLSENL----MVEEYLKN------------------S--ACE--K-A WPSLQTLILRQNHLTSLEKTGETLL---------TLKNLTDLDISKNTFH---------- ------------------------------------------------------------ --------AMPDT--CQWPERLR-----RLNLSST--RI-HSLTYC-IPQTLE------- -----------------------------------------ILDVSNNNLN------VFS L--------TLPRLKELYISRNMLKTLPGASLL----PMLLVMKISRNSINTFSK---EQ LESFQKVTALEAG--GNNFICSCDFLSLTQEQPALTRV-L---PDWPESYLCDSPS---H VRGQQV------------------------------------------------------ -----------QDARLSVSECHR-----AAVV-SGVCCALLLLTLLAVVLCRHFHG---L W-YLKMTWAWLQAKRKPR---KAA-CR-------DVCYDAFVSY--SE---------HD- --SYWVENLLVQELE-N---SDPPFRLCLHKRDFVPGKWIIDN-------II-DCIE-KS RKTVFVLSQNFV-KSEWCKYELDFSHFRLFDENNDAAIL-VLLEPIEKKAIPQRFCKLRK IMNTR-TYLEWPTEEAE---HAGFWGNLRAAIKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gorilla_ENSGGOP00000013642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPGSRPKKPLGKMADWF RQTLLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RPNSPESASSDASQPTSQDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLPPSLSSVTSPSLPPTH-----------TSDSGSSRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SS HCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQVLKHLLYPGTPEVGVKLETENPC RASDSHRCDKRYRE---------------------------------------------- ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000010425 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPGSRPKKPLGKMADWF RQTLLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RPDSPESTSSNTSQPASQDR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LSPSLSLVTSPSLPPTH-----------ASDSGSSRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQN-LVSYLE-G---SSTSLRCFLQLRDATPGGAIVSE-------LC-QALN-NS HCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGRTI---PLLSGLSR-------DAYPP ELRFM-YYVDGRGPDGG-------FRQVKEAVMRYLQTLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_carolinensis_ENSACAP00000007258 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PDLPVHVFTTG-IIMAIFFSFAAVFMVILYVVFRFELVL L------YREITGKDETL-------GD-------GKLYDAFVSYLKDS----VPIYGEE- --RKFALEVLPKILE-----DNFGYKLCIFERDISPGAAVIDD-------VQ-SFID-RS RRLIIILSKNYI--SDQVMFELEIGLHKALVERKIKVIL-IEYMPVTN--FDFLPMSL-Q LLSSK-QVVKWNKEKSL-PLNSRFWKKLRYAMPAK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000038393 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LFL SGLEDVKNMEMFRRYNEPVFYCFL------------------------------------ -------------LLALTKG----------------IWSQNSCQVDE--KQKYANCQGQN LNDVP---KDLP-----------------------VTLEVLDLSCNWISQIRVDDFSSYT NLQALNLSFN---------------NIST-IDNSSFASNTQLRNLTLF-NNGLTEMPSTL LEPLLLLEVLDLSDNLYNY----------------------------------------- -----------------------------------STLGKVFKTLANLRSLSIGG-PFVS KVLRGDFVPIKNISLQKFE-LKTRSS-LRFY----------------------QTGA--- -FSVL-NTDVLVLVMTL--DTNPKVLPMI--------------------LKDLAGKSLDI LSFG-----NLF---------------LPDINVRELIFNRG-KVNQKLLQLILETIQT-S SIQDLSLLSVDFDYSD---VRTTVDVKMDNL----------------------------- ------------------------------------------------------------ --------------------------------------------------FLRSLVIKD- ------------------------------------------------------------ -----------ATN---PDILTF---DQT--------FTWFSK-VSNLYIINVNFNFAQC DTWS-QMKNVERLDIRNNL----LLSSDLYN------------------P--SCKY-G-E LPKLHTFTAANNNLQILKPISLLTA---------NWPKLSSLDLSSNYIG---------- ------------------------------------------------------------ --------SEDEN--CSWTPNIT-----TFILKNN--LLTPGVFTC-LPTTVR------- -----------------------------------------YLDLSNSRLE------SLD MDY----FSNATNLKTLVLSYNKLTSISSNWSN----PFLQVLFLDNNIISIIDK---GS FNNLPQLRTLTAG--NNPYHCTCDLYSFFSDVLGKNKITI---SDWPQSYCCYHPQ---Q LRNTRV------------------------------------------------------ -----------DIYTPGSIECNV-----GLLV-AITVSTTAVVVIACMIMCWRLDA---P W-YFRMMCHIVKSKYRSK---KANDSR-------EYNYHAFISY--SY---------SD- --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-DNIE-TS RKTIFVLSHNFV-NSEWCNYELYFAHQRAIGHSFEDVIL-VVKENVTLKDLPKRFHKLRK MLRKK-TYLEWPSEPSK---QHFFWIQLK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000002903 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LYSSWEEECVERS FITALEGEPF------------------------------HLKCCLSA-RRHHKNKTFTW TKRYGRNSTMKLS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------SNENIIINGSVI------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EFWPIKMND- ------------------------------------------------------------ -----------------NGIYSCIAGNEN--------------KSWTISVTKKNRHGCFH P------NHLITIEADVGK----SLSINCIDD---------------------------Y YQKKDHRISLFKNCSPIPGNYRSSI---------------LKNAELKD------------ ------------------------------------------------------------ --------EGNYTCIFFLSNKYG-----SFNVTKT------------------------- ------------------------------------------FRVKV----------KDN ISRVPKLFGNMTNY--VEAELGKKKTLNCTAILD---------GTDGRLYWDYMEE--ND TNININKINSRCD---SNAMTRVSSLLEIKIVKEENLN---------MWYNCTLSS---P SITETI------------------------------------------------------ -----------AYFLKKKEGPADISRHI-----FIIALVSSAAVIFLVIMCVIYRVDILL C------YRDFLRRDETL-------LD-------GKEYDAFVSYLKDC----QSENGEE- --HKFALEILPEALE-----KHFGYKLCIFERDIIPGGAIVDD-------IH-SLIN-KS RRLIIVLSENYM--SSKVKYELESGLHEALVERKIKIIL-IEFTPIRD--FTFLPQSL-K LLKSH-RILKWKADKSL-PYNSRFWKNLRYLMPAKNTKNVFSSDPLGNELLPVVSKF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_gallus_ENSGALP00000026726 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MTN LSEVAAHRKMVHHARTSNALLFVLLFLFPMLLSGRWFPKTLPCDVEAFESTVRVDCSDRR LKEVPRGIPGNATNLTLTINHIPRISPASFTQLENLVEIDFRCNCVPPRLGPKDNVCVTP PSIENGSFAALTRLKSLYLDANQL--------------------SKIPRGLPATLRLLSL EANNIFSIKKNTFSELRNIELLYLGQNCYYRNPCNVSFEIEETAFLNLKNLTVLSLKSNN LTFIP---PNLS-----------------------STLKELYIYNNRIQEVQEHDLSNLY NLEILDLSGNCPRCYNAPYPCTPCPNISIKIHSKAFYSLKKLRILRLH-SNSLQSIPSSW FKNIKNLKNLDLSQNFLIKEIGDAEFLKLIPSLVELDLSFNFELQMYSPF---------- -----------------------------------LNLSKTFSCLSNLETLRIKG-YVFK ELREENLDPLLN--LRNLTVLDLGTNFIKIA----------------------DLRV--- -FKKFRSLKIIDLSMNKISPSSGEGN-----------------------FYGFCSDHRIT VE----------------QYSRHVLQEMHYFRYDEYGRSCKSKDKEADSYQPLVNGDCMS YGETLDLSRNNIFFVNSIDFQDLS------------------------------------ ------------------------------------------------------------ --------------------------------------------------FLKCLNLSG- ------------------------------------------------------------ ------------------NAISQTLNGSE--------FYYLS-GLKYLDFSNNRIDLLYS TAFK-ELKFLEILDLSNNKHYFLAEGVSHVLSFMKNLAYLKKLMMNENEISTSISTGM-E SQSLQTLEFRGNRLDIFWSDGKKEY----LSFFKNLTNLEQLDISSNMLN---------- ------------------------------------------------------------ --------FLPPDVFEAMPPELK-----ILNLTSN--RLHTFNWGK-LHLLTK------- ---------------------------------------LITLDLSNNLLT------TVP RKL----SNCTSTLQELILRNNRITRITKYFLRG-A-IQLTYLDLSSNKIQIIKKSSFPE -NIINNLRMLLLH--NNPFKCNCDAVWFVGWINQTQVA-I---PLLATDVTCAGPG---A HKGRSL------------------------------------------------------ -----------VFLDLNTCELDT-----SYFI-MYALSTSAVLCLMMFAVMSHLYF-WDV WYSYHYCTAKLKGYRRIP-------LP-------DACYDAFIAY--DN---------TDL AVNEWVMTELVEKLEDQ---KARQFNLCLEERDWLPGQPVFDN-------LS-QSIQ-LS KKTIFVLTNKYI-KSGTFKTTFYMAHQRLLDEKIDVIIL-IFLEKVLQ---KSRYVQLRK RLCRS-SVLEWPTNPRS---QPYFWQRLKNAIAMNNTLSYNKLLQETV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000004627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPGSRPKKPLGKMADWF RQTLLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RPNSPESASSDASQPTSQDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLPPSLSSVTSPSLPPTH-----------ASDSSSSRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQD-LVSYLE-D---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SS HCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGPDGG-------FRQVKEAVMRYLQTLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >G_aculeatus_ENSGACP00000002280 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------L-- ------------------------------------------------------------ --------------------------------------------------GRAADCTGGQ LERVP--WRQFP-----------------------STLEDLDLSFNELQAVHADDFHHLA QLRVLKLQYN---------------NISH-IDSEAFKNNGLLEHLDVF-NNSLAEIPASA LTPLLNLKVLNMSNNLYKH----------------------------------------- -----------------------------------ATLAKSFSRLVSLKVLSMGG-PLVM GLKKADFQPLKNIRLQGFA-IKCSTN-LKYY----------------------EPGS--- -LEVI-QTNQMGFDMAI--DQQPSALPHM--------------------LRDLANKTFSA IQFR-----NLFEFMYYMGEE-DIFQGLKYITAHQLIFHRG-KFNENLLRMALINLQV-T PIKSLRLQYIDFARSPTFVDSGASSS-ITDL----------------------------- ------------------------------------------------------------ --------------------------------------------------ALDKLDIWY- ------------------------------------------------------------ -----------VSN---PDVLRF---DWR--------FTWFNK-IKKLSIQHVDFNSSPC DSWV-EMEGVEHLDISNNR----LKNEFIFN------------------Q--RCNYQG-A MPNLRTFQINTNELTSLKVVSLLTK---------EFQQLQVLDLSNNQLG---------- ------------------------------------------------------------ --------SAGNSRDCVWHKSIT-----RLVAHHN--PFESEALRC-LPTTLQ------- -----------------------------------------YLDLSYCELD------QLD MGY----FKRATSLKELLLSGNKIKFIPSMWKS----SSLQSLALDGNSFGLISR---AS FQDMPQLSQLKAG--NNPYHCTCELHSFVQDTMNKAKVNL---TDWPWNYRCYHPE---S LRNTVI------------------------------------------------------ -----------SKFLPSQVACDI-----RLVV-IISVTTTAVVILTLMLICYIFDL---P W-YTKATYQIVRAKYRAHKEKAAGEGG-------AFTYHAFISY--SH---------SD- --ADWVRNQLLPCLE-S---NGNSYRLCIHERDFMPGRWIIDN-------II-DNIE-SS RKVIFVLSRHFV-NSEWCNYELYFAQQRAVGKTFSDVIL-VVKEPMDPNSLPSKYLKLKK MLRTK-TYLEWPQQVNQ---QAFFWTQLKGVLGKPTATQKRTHSVKS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_anatinus_ENSOANP00000002290 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TTVRLLLAFNHIRTVNATSFPLLE KLELLELGNQ---------------TAALTIHRDAFRNLPNLKVLDLG-YNPKLFLDPDA FRGLSNLLELRLFYCGLSESVLRDGHLRDLRSLIRLDLSANRIQS--------------- -----------------------------------LPLHASFQELRSLETLDLSK-NQIS SVCERDLQSLRGKHLSLLNLADNQLFSCRPV----------------------DWGACGN PFRNI-FLDTLDVSGNGWSANITQDF-----------------------CAAINGTRVSS LVLRHHVMGSGFGFENLKEPNSDTFSGLERSSAVQLDLSHGFIFSLGT-----RLFWALK RLKVLSLTHNKINKFEKGAFY--------------------------------------- ------------------------------------------------------------ --------------------------------------------------GLDTLQILN- ------------------------------------------------------------ -----------LSYNLLGELYNSNFDGLP--------KLKGLISLQILNLNSNRLTSLSH SDLP---ANLEKLDLSRNQ---------LLSPDPKLFHALKVLDLTHNSIITVNATSFPL LEKLELLELGNQTAALAIHRDAFRN----------LPNLKVLDLGYNPK----------- ------------------------------------------------------------ --------LFLDPDAFRGLSNLL-----ELRLFYC--GLSESVLRDRLFWALK------- --------------------------------------KLKVLSLTHNKIN------RFE KGA----FYGLDTLQVLNLSYNLLGELYNSNFDG-L-PNLKYIDLQQNHIGAIQDQTFTH L--KESLQVLDIT--HNRYICECELRDFLGWLNQSNVT-F---LGSPKDMYCVYPD---S FSGVSL------------------------------------------------------ -----------YSVSLEDCDEEEVLRPLKFSL-FLFFTVTLLLIIISVIVYTQFRG---- -----FCFIGIKTVTRLV-----LGDR-------PKRYDAYLCF--SG---------KD- --FEWVQRAFLMHLD-SQYNDNNRFNLCFEERDFLPGEDHISN-------IR-DAIW-NS RKTICVVTRQFL-KDGWCIEAFNFAQSRYFSDLKDRLIM-VVAGSLSQYQL-MKYQPIRV FIQRQ-HYLKWPENLQD---IGWFLDKLSQSVLKEKDVKKKAN----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_domestica_ENSMODP00000002923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MFSLHHIFLWLVIRAGVKGDSELSGCPTKSSW RYLARSGEKF---------------FLFCDVPRRGRISKKDICGKTRC-HDISCSSDVRW YKHPQNGS---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------QPYA--- ---ILNEHSHITWENHLL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QFSPVGIND- ------------------------------------------------------------ -----------------AGFYICTFKYEP--------KGITCFLNITLEVQPKEKTPCLD SVKN----ELFLLIGSTDR----VPCPGIN-----------------------------C ERDIQSEVTWYKNGTLCPRWTSTHI--------------EFTEIFYRD------------ ------------------------------------------------------------ --------RGVYVCDYKKSINST-----WWIVRAV------------------------- ------------------------------------------VDVIAV---------VKN TSSKPTILYPTVDMLTLEVELGKPLTLDCKAQFE------FERNFNPVIKWFVDDPGLNR KELREGNKSIE----NDVEQKTIHFIAHLKEVTKKDLR---------RNFICFAQN---S VGNTTL------------------------------------------------------ -----------TIKLKQKKGV------LFTYI-LFGTTITLVAILMTSALTYRYWIEIVL L------YRTYQAKDETL-------GD-------KKEFDAFVSYARDSFGDLDSSSLNE- --ESFALDLLPQVLE-----NKYGYTLCLFERDVIPGGAYTED-------IV-KIIK-QS RRVICVLSSSYV--NNPSVFELQAAVNLALEDQTLKLIL-IKFSPFKE--PDSLPQRVRK ALSVL-PTITWKNSKSA-PPNSRFWSRIRYHMPVKNCRKLGSQGFHFFPRIF-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_mulatta_ENSMMUP00000029702 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MTLL---- -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------F PSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIAFISN------------ ------------------------------------------------------------ --------NGNYTCVVTYPENGR-----TFHLTRT------------------------- ------------------------------------------LTVKVV--G------SPK NAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD IPIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---A KGEVAK------------------------------------------------------ -----------AATVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KS RRLLVVLSPNYVLQGTQALLELKAGLENMASQGNINVIL-VQYKAVKE--TK--VKEL-K RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----- ------------------------------------------------------------ ----------------------------------------------------------NV ------------------------- >P_troglodytes_ENSPTRP00000059752 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPGSRPKKPLGKMADWF RQTLLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RPNSPESTSSDASQPTSQDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLPPSLSSVTSPSLPPTH-----------ASDSGSSRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SS HCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQLLKHLLYHGTPEIGVKLETENPC RASDSHKCDKRYRE---------------------------------------------- ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000279992 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSTSLPAPGSRPKKPLGKMADWF RQTLLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RPNSPESTSSDASQPTSQDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLPPSLSSVTSPSLPPTH-----------ASDSGSSRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LVAAQD-LVSYLE-G---STASLRCFLQLRDATPGGAIVSE-------LC-QALS-SS HCRVLLITPGFL-QDPWCKYQMLQALTEAPGAEGCTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGPDGG-------FRQVKEAVMRSNQVLKHLLYHGTPEIGVKLETENPC RASDSHKCDKRYRE---------------------------------------------- ------------------------------------------------------------ ------------------------- >C_intestinalis_ENSCINP00000024401 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MECDCSMQSLSLW---YIQAETTYH YTSIQRYL---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPLC--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VEPPNRRNQRITTIFG AYYY-EYNCIPRVCTHRQG----------------------------------------- -----NLDCSYTTQQSINRTRFNVL----------------------------------- ------------------------------------------------------------ --------PTIPRNTYWLTLDLS-----NLQLENEKISLTQ------------------- ------------------------------------LTRLTTLNLTGNKLT------SIP LQG------LPRSIENINLSRNKISTLPATTLITYYLPNLKQLDLRNNSFSTIQT---QE VSIFLAVTSVLLR--GNPLECNCKLRPLITWIQTNEKNEQNLSTHDLKDLICFTPK---R FEGRYI------------------------------------------------------ -----------INLSESEYCPVVN----LSLIGGLVGGFTALLIIIIIIVNIYLYKKRKK Q-ERRDIVQGFKDLLEKEAMNEGDPETGVGVAPVTYEYDAFVSYVSDS---------DD- --VEFVYK-MLEEME-----EKRERKMCIHERDFTPGRGIADN-------IV-ECIS-TS RRMVLVVSRKYA-SSAWCQYEVQIALTELHAKRRGRLLVPILLEDVTR--DEQYAGSVTT ILSAI-TAIQAPKAQDNDRTWTNFWNKLDKTLT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >E_caballus_ENSECAP00000010139 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSSSFPAPRSRSRKPLGKMADWF RQALSK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPK---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VPVSPESTPSDVSQPSSQDS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------NPPQCLSSVVSPTPPPTNTGT-------SSSSSSSGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------QD- --LVAAQE-LVSYLE-D---SPAGLRCFLQLRDATPGGAIVSE-------LC-QALS-NS HCCVLLITPGFL-QDPWCKYQMLQALTQSPGAEGCTI---PLLSGLTR-------AAYPA ELRFM-YFVDGQGPDHG-------FRQVKQAVMRYLQTLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >R_norvegicus_ENSRNOP00000032224 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSSSVPASSTQSKKPRDKIADWF RQALLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MPISQESHLSDGSQTATQDG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LSP SSGSSPRSHSSSQSQSSTPSCSSGMSPTSPPTHV--------DSSSSSSSGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LEVAQE-LVSYLE-G---SKASLRCFLQFRDAAPGGAIVSE-------LC-QALS-GS HCRVLLITPGFL-RDPWCKYQMLQALTEAPGSEGCTI---PLLSGLTR-------AAYPP ELRFM-YYVDGRGQDGG-------FYQVKEAVIHLLDSMT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >H_sapiens_ENSP00000072516 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MTLL---- -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------F PSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ ------------------------------------------------------------ --------NGNYTCVVTYPENGR-----TFHLTRT------------------------- ------------------------------------------LTVKVV--G------SPK NAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---A KGEVAK------------------------------------------------------ -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KS RRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----- ------------------------------------------------------------ ----------------------------------------------------------NV ------------------------- >P_troglodytes_ENSPTRP00000027076 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MTLL---- -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------F PSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ ------------------------------------------------------------ --------NGNYTCVVTYPENGR-----TFHLTRT------------------------- ------------------------------------------LTVKVV--G------SPK NAVP-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---A KGEVAK------------------------------------------------------ -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KS RRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----- ------------------------------------------------------------ ----------------------------------------------------------NV ------------------------- >X_tropicalis_ENSXETP00000032922 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------LVMPILILSYVI CSCVT------------------------------KSIKTLGWFCSSLERCDDWGVDTMK LIQAYEGEPA---------------RIRCPLFQDFLK-----HNYSTA-HSAGLTLMWYW TGQGKDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPVN--- -IRL--PNNRIIKDKDTL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPAIIND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------F--CSRVAFPLEVVRKDADSCVS QAVK-PEVVELPLEH-TER----LPCPDTDGF---------------------------F PVNVTPSVTWYKDCIS-ENFYERLP---------QGLNLTFIVVRSNY------------ ------------------------------------------------------------ --------QGNYTCIVTYEDSGK-----IYNLTRT------------------------- ------------------------------------------SEVKVV--G------LLP SVCPLPLFPFYIQLFILFVSSGEEMLLSCEVFCP------FVRNSRNDVWWTVDGKKLEE ILKGLLL---------LXGNCNKSKALNYTLLSDKVII---------VH--CYSHI---S HLVISG------------------------------------------------------ -----------LA-LYHSLCSPRQIIWYITEL-ACGLGATLFLVVCLIIVYHVYWLEMVL F------YRAHFGTDETI-------GD-------GKEYDVYVSYARNA---------EE- --EEFVLVTLRGVLE-----NEFGYKLCIFDRDSLPGGTVTDE-------TL-TFIK-KS RRLLVVISPSYILKGTQALLELKAGLENMATQGNIRIIL-VQYKAIKS--REK-VKEL-K LAESVLGVIKWKGDKSK-FPNGRFWKQLHVAMPVKKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000009956 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KCITR RNCWGQKKECWSNTCPIAALMTLI------------------------------------ -------------LQPISFI----------------ECYGYRKCSLEGIHTEYANCVGQS VVTLADAIQDLP-----------------------YQTRVLNISENEISKIDGYTFSHLP KLQELVLRKN---------------KVNG-VDTWAFHNLNDLLILDLS-YNLIQSLDTVD LTDLKHLQIFDLSHNRIHTI--QMGTLGPLGALQELDLSFNNVSDFRSVANAVSQLPDFL RLSLSSNFITDLKSEQSVTVLSSLQSLNLRNNSI-SVLDFTFYSMPSLIELNVTR-NNLS AVNKSSFSNLPM--LAKVT-FDENSLNISQLLGLVLPNLTEFHWSSMRPALQHELVSACQ VFQTFPKLQLLDIKHSKIAVTNLSIIGRCTNLTSLILSTSPLPRLQEKDLQDFKYLEVLY LDKCKLRRIANSSWRGLNNLHTLILERNQLSDLEDKLFSPL------------------T SLQYLDLSKNYLTHLNEKAFSGLR------------------------------------ ------------------------------------------------------------ --------------------------------------------------RLNYLSLKG- ------------------------------------------------------------ -----------------CKITAATRNN----------FRYFS-NLRVLDLQDNSISLIKS NAHI-YLRKLETLLLSGNK------ILTIQKNGLKGLVSLKELSLANNNIYKITDNTFKF VKSLRSLDLSRNQLWPLHKFQSPTP-------FLNLTQLEYLDASYQAEGN--------- ------------------------------------------------------------ --------IYIPASLFQGLQSLK-----VLRLQGNPSAFFRNVSFE-FLLNLT------- -----------------------------------------ELDISATVYTMTDPPISFE KEL----FKKLGQLRNLTLDNNGIQFLPEDVFTN-V-PMLEHISLRYNRLTNISE---DI LKNVPNLNYFDMY--MNTLSCSCDNYWFQNWSKCNTEV-Q---IPFIQSYKCFGLEANEM LFENQD------------------------------------------------------ -----------FSFCTNTGYYFFLG---SFII-TFSLLTVNLLVVKLKWTVRYMYCMLEV W---------FRWKLETT-------DK-------VHKYDAYISY--CE---------DD- --EIWVVEKLLHMLEEQ---GQRKFKLCFKPRDFVPGIYHLDN-------IQ-DAIS-NS RKTLCVVSRKYL-ESEWCREEMQLACSWAFSYKEDVLLM-VFLEEIPEYRL-SAYHKLRK LIKQN-TYIDWPEDPRG---EEVFWLKLRQALDGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_pygmaeus_ENSPPYP00000016111 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MTLL---- -WCVV------------------------------SLYFYGILQSDASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----FNYSTA-HSAGLTLIWYW TRQDRDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PENRISKEKDVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPTLLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMK-LPVHKLYIEYGIQR----ITCPNVDGY---------------------------F PSSVKPTITWYMGCYKIQNFNNVIP---------EGMNLSFLIALISN------------ ------------------------------------------------------------ --------NGNYTCVVTYPENGR-----TFHLTRT------------------------- ------------------------------------------LTVKVV--E------ALQ KCSA-PVIHSPNDHVVYEKEPGEELLIPCTVYFS------FLMDSRNEVWWTIDGKKPDD ITIDVTINESISH--SRTEDETRTQILSIKKVTSEDLK---------RSYVCHARS---A KGEVAK------------------------------------------------------ -----------AAKVKQKVPAPR----YTVEL-ACGFGATVLLVVILIVVYHVYWLEMVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KS RRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-SSSDEQGLSYSSLK----- ------------------------------------------------------------ ----------------------------------------------------------NV ------------------------- >A_aegypti_AAEL000633-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MRPSPALLSVLFGT-IFGVFGASLSKSLLSQAPDECRWSGYSEDDLTL VCRLRTINS------ELENTNFSVLHPENTVRLRLQCNDGLFFQSSISPGSFRQLSELRS LSIEYCKIANLSDG-SFRGLKELM-------------------------NLTLRTHNTDW SSVSLEIAPHVFNSELSKLE----------------QLDLSQNNMWSI--PDGMICPLTK LQYLN--LTQNR-LRDLSVFHFSASLSTRLSKKCGGSITILDLSHNNIDNLPPAIFSGLG KLTELRLQNN---------------GLNF-IADRALEGLLSLSKLDIS-LNRLSNLPPEL FSEAKHIKEIYLQNNSINVL--APGIFSELQQLLVLDISNNELTSEWINPATFKGLSRLI LLDLANNKISKLEPSIFR-DLFSLQILRLQDNFIETIHEGTFSELTALHTLVISN-NRLS NIEYFSFQGLSR--LTLLS-LDYN-R-ISRI----------------------DRVA--- -FRNLSTLHDLHLNGNKL-LQVPDALYDVPLLRTLDLGENHISNIDNASFKEMFHMYGLR LTEN------------------------NVETIRKGTFDAM------------------K SLQILNLSKNRLKKVDAACF-DNNT----------------------------------- ------------------------------------------------------------ --------------------------------------------------NLQAIRLDG- -------------------------------------------NYLTDISGL-------- -------------F---TKLPNLVWLNISDNHLEVFDYALIPTGLQWLDIHANKIAELGN YFEIESQLALSTIDASSNQ----LTEITGSA---IPNSVELLYLNDNLISKVQSYTFF-K KPNLTRVDLFGNKITTLDPNALRIS------AVPDDRALPEFYIGGNPYQCDCN----LN WLQKNNVDSRTQPKLMDLDSIYCKLLYNRGRTYVPLVEALPNQFLCKYETHCFALCHCCD FYACDCKMECPARCTCYHDQSWT---SNVVDCSRA--GYEEQLPEQ-IPMDSTQIYLDGN NFRTLSSHAFLGRKKLKVLFLNNSNVEMISNRTFYGLKELEILQLDHNQIT------GLN GFE----FVGLDRLKELLLQFNKISTI-ANHSFD-HLPNLRVLRLDHNRIVEFN----MW -HLPKQLTDLRLA--SNPWSCDCEYVEKFREYLKTYDF-V---RDKVKVRCSATITSGND TAMIVGGAVNGSATGASAVIPKGVPDGSGESNGVGVGGFLIYLDNSTTLCSGAVPLDNII N----------GNLTSRKTVLSPPPIEGYIPL-LVAALCGFTVIIIMTLIMFVFRQEMRV WFHSRFGVRLFYR-NADM-------DKN----ERDKLFDAFVSY--SS---------KD- --EAFVAEELAPMLE-N---GDPSYKLCLHYRDFPVGAYIADT-------IV-QAVE-SS RRTIMVLSENFI-KSEWCRFEFKSAHHQVLRDRRRRLIV-ILLGEVPQ---KDLDPDIRL YLKTN-TYLQW-----G---DKLFWEKLRFALPDVPNN-QRRR---QQQSINMTHSNFRN NYQLTR-TPNNRNNTSNQLIMLQQQPPQPDPRLRQQQQQEHSSLQQQPLPLPGLAQQPQP PQLLQHQRQQQQQQQEQQQR---------------------------------------- -------GAGNAS-PRTVGIHI--- >G_gallus_ENSGALP00000001610 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AGWF RRLLQ------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------KPKQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SSIH ASSSSHSTTSHSLSSSPSSFSSSSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AWSSSSSSSTSTAQPSRPA-------PVDISSSSSARW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VKSYDVCICH--SE---------VD- --LEFVEE-LVSYLE-S---QPQSLRCFLQLRDSVAGSAVMTE-------LC-EAVQ-NS HCWVMLITPSFL-QDPWCRYQMHQALAEAPMANGRTI---PVLKDIDR-------KDYPR ELRNL-YYIYVALKENS-------FRQIRDTVLRYLEELCRSSTSGMQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >O_cuniculus_ENSOCUP00000004210 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MRLL---- -WCVM------------------------------SLYFYGIPQSDASERCDDWGLDTMR QIQVFEDEPA---------------RIKCPLFEHFLK-----FNYXXX-XXXXXXXXXXX XXXXXXXX---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------XXXX--- -XXX--XXXXXXXXXXXX------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------XXXXXXXXX- ------------------------------------------------------------ -----------------XXXXXXXXXNTT--------Y--CSKVAFPLEVVQKD--SCFN SPMK-LPVHRLYIEYGIQK----ITCPNVDGF---------------------------F PSTVKPIITWYMXXXXXXXXXXXXX---------XXXXXXXXXXXXXX------------ ------------------------------------------------------------ --------XXXXXXXXXXXXXXX-----XXXXXXX------------------------- ------------------------------------------XXXXXX--X------XXX XXXX-XXXXXXXXXXXXXXXXXEELLIPCEVYFT------FLMDSRNEVWWTIDGKKPDD ISIDVTINESLSY--SKTEDETRTHVLSIKKVTPEDLK---------RNYVCHARN---A KGEVDK------------------------------------------------------ -----------AAKVKQKXXXXX----XXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX X------XXXXXXXXXXX-------XX-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-SFIQ-KS RRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVIL-VQYKAVKE--TK--VKEL-K RAKTVLTVIKWKGEKSK-YPQGRFWKQLQVAMPVKKSPRR-CSSDEQGLSYSSLK----- ------------------------------------------------------------ ----------------------------------------------------------NV ------------------------- >X_tropicalis_ENSXETP00000057557 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KKCIFYIYICVY------------------------------------ -------------MHVFSKT----------------THNKVHN------KEGILNMLWHL KKK-----KKIH-----------------------IHTYIYDFTKENITHLKTSDFNCFL QLRLLNLSHN---------------LIGE-LDCSVFKFNPSLEYLDIS-NNRLHTIKCHS LQYIKNIKRMDLSYNNFKT----------------------------------------- -----------------------------------MDFCSEFTALSQLKHLGLSS----K KIQKDSFINIASMDLDFVF-LG-IEN-EIEY----------------------ENGS--- -LQFL-NTNKLHINLQP---NLSLASSYL--------------------LSDALD-TSMT LEVS-----GAQCDVHCDYFTKSFFTINKNSKVVNLIISNS-TMPGNEMLKIIPPIWD-S SVEHLHIKMFRLIKEFKYVKMDFTHH---------------------------------- ------------------------------------------------------------ --------------------------------------------------SIKSFTLEY- ------------------------------------------------------------ ------------FT---NDVFFFQGTHPF--------NIFAEMLVENVTFSNAGMIHFFC PPVP-SI--VRFLNLPSNR----ITDEIFLN------------------C-------S-S LNELELLNLQNNKLEQMSKISSMTL---------KMKNLKHLDLSKNGLH---------- ------------------------------------------------------------ --------IDNEKQ-CNWMDSLV-----FLNLSES--GLTNSVFGC-LPINLQ------- -----------------------------------------ILDLSKNQIS------SIP I-E----VKNFVSLKELHLASNRLTDIPDCHNIG---NNLGVLKVDENFINLPPK---EF LQNCEYVQYLSAG--QNPFQCNCDLREFVKMGVMFPKR-L---VGWPESYKCADPE---N VKGIFL------------------------------------------------------ -----------QDFHLSEISCNT-----SLFL-GVVLGTIFVVSIIVVSACFYFDV---P W-YIRMLFRWFRTKHRLRNVNQQDIQN-------DKLFHAFISY--SQ---------ED- --SDWVKNMLLPNLE-R---KDGSIKICHHERHFIPGKAIIEN-------II-DCIE-KS FKSIFVLSPNFI-QSDWCHYELYFAQHTLFGKNSNNLIL-ILLDPIPQYSIPNKYNKLRS IMKHR-TYLEWPKEKGK---HALFWANLREAIHVNLSIKEEDMADPEITIT--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >A_gambiae_AGAP012385-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MRPSPALLTVLFGT-IFGVFGASLSKSLVSQAPDECRWDGYTEDDLTL LCRLRTINS------ELENTNFSVLHPENTVRLRLQCNDGLFFQSSLSPGSFKQLTKLHA LSIEYCKIANLSEG-SFQGLKQLV-------------------------NLTLRTHNTDW SSISLDIAPQVFTSELAKLQ----------------RLDLSQNNMWSV--PDGFICPLAR LSYIN--LTQNR-LRDLSVFHFSASLSTRLSKKCGSSIVTLDLSHNTIDNLPPAIFSGLG KLTDLRLQSN---------------GLNY-IADRAFEGLVSLSRLELS-LNRLTNLPPEL FSEAKHIKEIYLQNNSLNVL--APGIFSDLKQLLVLDLSNNELTSEWINPATFGVVQAHP TRSFKQQNNEARAHDLPRSDQRAGVALRKTSS---KASAKTFLGLGALHTVILSN-NRLC TVDHFTFSGLNS--LALLS-LDYN-R-ISRI----------------------DRQA--- -LRNHSALQELHLNGNKL-LQVPDALYDVPLLRTLDLGENHISNIDNASFRHMAHLYGLR LTEN------------------------NIEIIRRGTFEAM------------------K SLHILNLSQNRLKTVEQASF-DNNT----------------------------------- ------------------------------------------------------------ --------------------------------------------------KLQAIRLDG- -------------------------------------------NYLTDIAGL-------- -------------F---TKLPNLLWLNISDNHLEVFDYALIPTGLQWLDIHANKITELGN YFEIESQLALSTIDASSNQ----LTEITGSA---IPNSVELLYLNDNLISKVQSYTFF-K KPNLTRVDLFGNKITTLDPNALRIS------AVPDDRPLPEFYIGGNPYQCDCN----LN WLQKSNIDSRTQPRLMDLDSIYCKLLYNRGRTYVPLVEALPNQFLCKYDTHCFALCHCCD FYACDCKMECPKQCTCYHDQSWS---SNVVDCSRA--GYDDRLPDQ-IPMDSTQIYLDGN NFRSLSSHAFLGRKRLKILFLNGSNVETVSNRTFYGLKELEILQLDHNLLT------ALN GFE----FEGLDSLKELFLQYNRIASI-ANHTFD-HLHGLKILRLDHNRLVEFN----VW -LLPKQLNDIRLA--FNAWSCECDYVTRFQEYLKTYDF-V---RDRHKIRCASYVSSNAT IAPATQPADASQASPAEEPLP----------DGAGTGDFLVYYDNSSTLCTGAIPLENVI N----------GNLTSRKTILSPQPIEGYIPL-LVTGLFGFSLVIILTLVLFVFRQEMRV WFHSKFGVRLFYR-NADI-------DKN----ERDKLFDAFISY--SS---------KD- --EAFVAEELAPMLE-N---EDPSYKLCLHYRDFPVGAYIADN-------IL-QAVE-SS RRTIMVLSENFI-KSEWCRFEFKSAHHQVLRDRRRRLIV-ILLGEVPQ---KDLDPDIRL YLKTN-TYLQW-----G---DKLFWEKLRFALPDVPNN-QRRQ---HQPNISLTHSNVRN SYQLTRVAPSNRTN--NQLTAQHQDPRGPQGR----STDYHAT--QQPLPLPGLASEMQP QQLHSSQQQQQQQQQQQQQQQQQQQQQQQQQQQHQPPS---------------------T QAQLRPSAPLNTP-PNSWHSHLKAH >A_carolinensis_ENSACAP00000000788 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERCDDWGVDTMK HKPVYNGEPA---------------RIKCPLFEAFLK-----YNYSTA-HSAGLTLIWYW IGRGQDLE---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EPIN--- -FRL--PDNHISKEKDTL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------WFRPALLND- ------------------------------------------------------------ -----------------TGNYTCMLRNTT--------Y--CSKVAFPLEVVNKDPGSCVS QAVK-PEEVLLYLSYTNIN----LTCPDVEGF---------------------------S PANVQPKFNWFMNCNLVHNFYERRT---------HGINLTFIIVREMY------------ ------------------------------------------------------------ --------AADYSCVATYRENGR-----DFNLTRT------------------------- ------------------------------------------FRVKVV--A------APY RSTV-PQIITPDSRVIYEFKPGVDMSLVCEVHFT------FLKDSPQEVWWTIDGRTTDE VT-DLKFNEP-----LTVGDVKVTKTLFVSKVTEKDLR---------RNYTCFAHN---N NGTSQM------------------------------------------------------ -----------QALVRMKAVVPR----YTLEL-ACGLGATVLLVVALTVIYHAYWLELVL F------YRAHFGTDETI-------LD-------GKEYDIYVSYARNA---------EE- --EEFVLLTLRGVLE-----NEFGYKLCIFDRDSLPGGIVTDE-------TL-GFIQ-RS RRLLVVLSPNYVLQGTQALLELKAGLEDMASRGTIKVIL-VQYRAIKK--SK--VKELRQ AKAAL-SVIKWKGEKSS-YPRGRFWKQLLVEMPIKNRPKSTAAADRRTSSFSSLKEV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >X_tropicalis_ENSXETP00000054706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------L-- ------------------------------------------------------------ --------------------------------------------VDE--SRRFVSCSGRN LVEIP---KNFS-----------------------VTLEELDMSFNRIFQIKSDDFSAYT NLRALNLSYN---------------QIAT-IENGSFNSNTQLRSLTLF-NNSLTEMPSAL LEPLHLLEFLDMSNNFYNK----------------------------------------- -----------------------------------STLGDVFQTLVNLQTLSIGG-PLVS KVQKDDFVPIRNIGLQKFA-LKTMSS-LTLY----------------------EEGA--- -FSVL-NTHVLWFDIAL--DTNPQALLLI--------------------LKDLK------ ---------------------------LPSISTRELVFYRG-KFNENLLWIMLENIQR-S SILDLSLLSVDFSRSH---SANKTNTTVEFLDLSHSQLEQLDMDYFNKATNLKQLILSHN KIKFISSEWKSPNLQVLALEDNSFGVINVGSFKDLPKLRNLTAGDNPYGCTCDLYRFFSQ IRELRALNLSYNNISAIETGSFASNVLLTNLTLFNNSLTEMPSALFEPLRFLQFLDISNN FYNCATLGAEFSMLENLRNLSIGGPLVSKVLKGDFAPIKNISLQRFSLKTMSSLWLYEKG AFSDLNTQSLCVTN---PDILRF---DWT--------FTWFNK-VSHLDIINVNFNFVPC DAWS-QMVNVERLDISNNR----LLASNLYN------------------L--LCQY-S-E LPNLHTFIASDNNMRSLYTLSLLTL---------TWPKLATLDLTSNYLG---------- ------------------------------------------------------------ --------ALDEV--CTWTPQIT-----KLILKDN--T---------------------- ------------------------------------------------------------ ------------------LNQNKLKFISRDWKC----PNLQVLGLEGNSFSVIDK---GS FKDLPELRRLTAG--DNPYHCTCDLYAFFTETLTERRVSL---ADWPEEYNCYHPP---H LLDTKV------------------------------------------------------ -----------EFYNPGRVECDV-----RLVV-AISVSTTAVVVMLCMLLCWRFDV---P W-YLRTTCSIVQSKYRSR---SFHDSR-------DYNYHAFISY--SH---------SD- --ADWVRGELLYRLE-S---CSPPYRVCIHERDFLPGRWIIDN-------II-ENIE-SS RKIIFVLSRNFV-NSEWCNYELYFAHQRAIGHAFEDVIL-VVKEKVTMEDLPKRFQKLRK MMRTK-TYLEWPSEQNR---QHFFWIQLKSILGSPTGTSSSSSLCSWNQVSDSYP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >P_troglodytes_ENSPTRP00000021076 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SCTSRP HITVVEGEPF------------------------------YLKHCSCSLAHEIETTTKSW YKSSGSQEHVEL------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------NPRS--- -------SSRIALHDCVL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EFWPVELND- ------------------------------------------------------------ -----------------TGSYFFQMENYT--------------QKWKLNVIRRNKHSCFT E------RQVTSKIVEVKK----FLQITCENS---------------------------Y YQTLVNGTSLYKNCKKLPLENNKNP-------------TIKKNAEFED------------ ------------------------------------------------------------ --------QGYYSCVHFLHHNGK-----LFNITKT------------------------- ------------------------------------------FNITIV---------EDR SNIVPVLLGPKLNH--VAVELGKNVRLNCSALLN----------EEDVIYWMFGEENGSD PNIHEEKEIRIMT---PEGKWHASKVLRIENIGESNLN---------VLYNCTVAS---T GGTDTK------------------------------------------------------ -----------SFILVRKADMADIPGHVFTRG-MIIAVLILVAVVCLVTVCVIYRVDLVL F------YRHLMRRDETL-------TD-------GKTYDAFVSYLKEC----RPENGEE- --HTFAVEILPRVLE-----KHFGYKLCIFERDVVPGGAVADE-------IH-SLIE-KS RRLIIVLSKSYM--SNEVRYELESGLHEALVERKIKIIL-IEFTPVTD--FTFLPQSL-K LLKSH-RVLKWKADKSL-SYNSRFWKNLLYLMPAKTVKPGRDESEVLPVLSES------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------- >M_musculus_ENSMUSP00000091395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MASSSSVPASSTPSKKPRDKIADWF RQALLK------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KPKK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MPISQESHLYDGSQTATQDG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LSP SSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHV---------DSSSSSSGRW------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SKDYDVCVCH--SE---------ED- --LEAAQE-LVSYLE-G---SQASLRCFLQLRDAAPGGAIVSE-------LC-QALS-RS HCRVLLITPGFL-RDPWCKYQMLQALTEAPASEGCTI---PLLSGLSR-------AAYPP ELRFM-YYVDGRGKDGG-------FYQVKEAVIHYLETLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------