10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000364878 ---------------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI-- P_troglodytes_ENSPTRP00000047678 ---------------------------------------------------------------------------MADEKPSNGVLVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI-- P_pygmaeus_ENSPPYP00000004372 ---------------------------------------------------------------------------FTDEKPSNGVPVHMVKLLIRTFLDG--IFDDLMENNVLNTDEI-- M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000006810 ---------------------------------------------------------------------------LAGRGPEKEDPVNLMKSIARNMFEG--FLDDL-ENNVLSRDDL-- G_gorilla_ENSGGOP00000011776 ---------------------------------------------------------------------------MADEKPSNGVPVHMVKLLIKTFLDG--IFDDLMENNVLNTDEI-- C_familiaris_ENSCAFP00000021904 ---------------------------------------------------------------------------VLTGKRQSQDPVNAIKVVASTMLNS--FLEDLKEKNVLNKQEL-- M_musculus_ENSMUSP00000027009 ---------------------------------------------------------------------------MAARRTHERDPIYKIKGLAKDMLDG--VFDDLVEKNVLNGDEL-- R_norvegicus_ENSRNOP00000029448 ---------------------------------------------------------------------------FTAKRTHERDPIYKIKGLAKDMLDG--VFDDLMDKNVLNGDEL-- P_pygmaeus_ENSPPYP00000004373 ----------------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQNVLNWKEE-- P_troglodytes_ENSPTRP00000041705 ----------------------------------------------------------------------------MAEGNHRKKPLKMLESLGKDFLTG--VLDNLVEQNVLNWKEE-- B_taurus_ENSBTAP00000027820 ----------------------------------------------------------------------------MAEDKHNKNPLKMLESLGKELISG--LLDDFVEKNVLKLEEE-- C_familiaris_ENSCAFP00000031565 -------------------------------------MYSSRQQHGLSLEHILKNGEIARDGKTYVVPIVEGVFVFLTEDKHDKNPFKILETVGKELITG--VLHGLLEKDILKLEDA-- H_sapiens_ENSP00000347741 ----------------------------------------------------------------------------MAEGNHRKKPLKVLESLGKDFLTG--VLDNLVEQNVLNWKEE-- M_mulatta_ENSMMUP00000012893 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010831 ----------------------------------------------------------------------------MAEDRQERNLLKTLESVGKELITG--LSVGLVEKDVLKLKEE-- M_domestica_ENSMODP00000034020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034022 ----------------------------------------------------------------------------LTDKVLMEKRRLFVESVDRGVMNG--LLDDLLEVQVLNLEEM-- M_mulatta_ENSMMUP00000012894 ------------------------------------------------------------------------------------------------MLHG--VFNHLAKHDVLTLNEE-- P_troglodytes_ENSPTRP00000007279 -------AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNLVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE-- H_sapiens_ENSP00000376849 -------AVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE-- E_caballus_ENSECAP00000021890 -----------------------------------------------------------------------------TGNVLKEKRRLFIRSVGTGTVNS--LLDELLEKRVLNQEEM-- H_sapiens_ENSP00000260309 ----------------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTRVLNKEEM-- P_troglodytes_ENSPTRP00000059619 ----------------------------------------------------------------------------MADKFLKEKRKLFIRSMGEGTING--LLDELLQTRVLNQEEM-- P_pygmaeus_ENSPPYP00000004374 -------AVPIVEGVFIFLIEDSCKKKRRKNFEAVFKCILQSGLDNLVINHMLKNNVAGQTSIQTL-PNTDQKSTSVKKDNHKKKTIKMLEYLGKDVLHG--VFNHLAKHDVVTLKEE-- M_domestica_ENSMODP00000034033 ----------------------------------------------------------------------------LTDKVLKEKRRLFVESVDRGVING--LLDDLLELQVLNLEEM-- G_gorilla_ENSGGOP00000015374 -------------------------------------------------------------------------------DNHKKKTVKMLEYLGKDVLHG--VFNYLAKHDVLTLKEE-- P_pygmaeus_ENSPPYP00000004377 ----------------------------------------------------------------------------MADKVLKEKRKLFIRSMGEGTING--LLDELLQTRVLNKEET-- B_taurus_ENSBTAP00000027821 -----------------------------------------------------------------------------------EKRKLFVHSVSKGTING--LLDELLEKRVLNQEEM-- M_musculus_ENSMUSP00000027012 ----------------------------------------------------------------------------MAENKHPDKPLKVLEQLGKEVLTE--YLEKLVQSNVLKLKEE-- R_norvegicus_ENSRNOP00000009993 ----------------------------------------------------------------------------MADKILRAKRKQFINSVSVGTING--LLDELLEKRVLNQEEM-- M_musculus_ENSMUSP00000027015 ----------------------------------------------------------------------------MADKILRAKRKQFINSVSIGTING--LLDELLEKRVLNQEEM-- O_anatinus_ENSOANP00000016591 ----------------------------------------------------------------------------PPAQLLKDRWCLIIESLTHGMISG--LLDDLLQMQVINQEEM-- O_cuniculus_ENSOCUP00000000956 ----------------------------------------------------------------------------MADRILKDRRKRFINSVGTGTING--LLDELLEKRVLNQEEM-- R_norvegicus_ENSRNOP00000058685 ----------------------------------------------------------------------------LTENNHPDKPLKVLEELGKEFLTE--YLEKLVQSNVLKLKEE-- M_mulatta_ENSMMUP00000012901 -----------------------------------------------------------------------------TDKVLKEKRKLFIHSMGEASL---------------------- G_gallus_ENSGALP00000001569 ---------------------------------------------------------------------------------LLRVRADFVSRVRKAVVSN--LLDELLAHRVLNQAEV-- X_tropicalis_ENSXETP00000017024 -----------------------------------------------------------------------------LAAQLKKVRKLFIDGCNAAIINN--LLDDLLDKSVLTDSEV-- G_aculeatus_ENSGACP00000013201 ----------------------------------------------------------------------------YFSDKLKKVRTKFVEKASMSLIKQ--LLDDLLDNGILNDGQK-- A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006490 ----------------------------------------------------------------------------------YKDVLKEMESAGKAIAGS--FMDNLVKKKVIKLEKA-- D_rerio_ENSDARP00000034228 --------------------------------------------------------------------------------MAKSIKDHLQDALSNIGADN--LRRFQSRLGDRKQEPRVR T_rubripes_ENSTRUP00000019853 ----------------------------------------------------------------------------LP-DQLASIRPMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK-- T_rubripes_ENSTRUP00000035020 ----------------------------------------------------------------------------ME-DKLTSIRLMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK-- O_latipes_ENSORLP00000007938 ---------------------------------------------------------------------------------------------------------MLLQDKVLNDEER-- T_rubripes_ENSTRUP00000013027 ----------------------------------------------------------------------------MAICQLDSIRLMFVEKVSTQMINQ--LLDDIFMDGIVSEMEK-- D_rerio_ENSDARP00000059407 --------------------------------------------------------------------------------KMEDITKLITDVLEELVESE--LKEFKRQLWMGVKKGV-- D_rerio_ENSDARP00000068268 ---------------------------------------------------------------------------------MEDITQLLSDVLEDLVESE--LKQFTRQLWIGVKPGV-- D_rerio_ENSDARP00000008601 -------------------------------------------------------------------------------------MTEEVNWDEDLEVDA--VVQNLNLYKTVMRNDKNS C_elegans_C48D1.2 ---------------------------------------------------------------------------MMRQDRRSLLERNIMMFSSHLKVDE--ILEVLIAKQ-VLNSDNGD G_gallus_ENSGALP00000029853 ------------------------------------------------------------------------GACGMQRYHQEALKKNRVMLARELVLKE--LMEHMIEKD-IITIEMVE A_carolinensis_ENSACAP00000006831 --------------------------------------------------------------------SRMLGVCGMQKCHQEALKKNRVSLAKQLVLKE--LMEHLIEKD-VITEEMME D_rerio_ENSDARP00000075318 ----------------------------------------------------------------------------MADQLLENLRPDLIKGLSERVING--LLDDLQQKKVFGEEEI-- X_tropicalis_ENSXETP00000015203 ----------------------------------------------------------------------MLG--GMQKHHKDALQRLRVTLLHDMIIEE--LVEHLVSSG-ILTPIMHS M_musculus_ENSMUSP00000031895 ---------------------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE R_norvegicus_ENSRNOP00000022672 ---------------------------------------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE E_caballus_ENSECAP00000003321 ---------------------------------------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE B_taurus_ENSBTAP00000024166 ---------------------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVLAKELLLSE--LLEHLLEKD-IITLEMRE O_anatinus_ENSOANP00000005545 ----------------------------------------------------------------------------MQPCHQEALKKNRVALAKQLMLSE--LLEHLLEKD-VITMEMRE H_sapiens_ENSP00000312664 ---------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE P_troglodytes_ENSPTRP00000033921 ---------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016588 ---------------------------------------------------------------------RILGVCGMHPHHQETLKKNRVMLAKQLLLSE--LLEHLLEKD-IITLEMRE O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000037606 --------------------------------------------------------------------RSKMLHCGMREQDARTLRRQSAVLCKQLVVDE--LLIQCLQADDILTESMAE C_familiaris_ENSCAFP00000005409 ---------------------------------------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013612 ----------------------------------------------------------------------MLAACGMQRCHQEALKKNRVMLAKQLVLNV--LVEHMVEKD-IIPTEMVE P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020323 ---------------------------------------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015114 --------------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCLLKDLVVDE--LLIQALVKDGILTQNMAE G_aculeatus_ENSGACP00000013740 --------------------------------------------------------------------------CGMQERDRLALRTRSTVLCKQLVVDE--LLIQSLQTDEILTEAMAE O_cuniculus_ENSOCUP00000001859 ---------------------------------------------MAAPSAGSRASLQQKGLLAADRGRRITAVCGMHPDHQETLKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE M_domestica_ENSMODP00000001598 ---------------------------------------------------------------------RMLGVWGMEQEHQEALKKNRVVLAKQLLLSE--LLEHLLEKD-IITLEMRE T_nigroviridis_ENSTNIP00000009934 -----------------------------------------------------------------------------------------------------------------------M T_rubripes_ENSTRUP00000040691 ---------------------------------------------------------------------------------------------------------------------TNM T_nigroviridis_ENSTNIP00000010874 -----------------------------------------------------------------------MLQCGMVERDAQALKKQSAVLFKQLVVDE--LLIQFLQADDILTDSMAE T_guttata_ENSTGUP00000006879 ---------------------------------------------------------------------------------------------------------------------MTD D_rerio_ENSDARP00000083664 ----------------------------------------------------------------------MLGECGMTKWERLALRRNSVKMLQDLVVDD--LLIQCLQQDGILTDSMAE G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 ----------------------------------------------------------------------------MEESQRELFQKNRLRLVCELQVEP--LWDLMLDRE-LFTRDMIE G_gallus_ENSGALP00000017288 --------------------------------------------------------------------------------------------------------------------MMTD E_caballus_ENSECAP00000015102 ----------------------------------------------------------------------------MNEADRQLLRRSRLRLVRELQVDS--LWDALLTRE-LFTPDMIE E_caballus_ENSECAP00000013731 -------------------------------------------------------------------------------------------------------------MA-DDQDCVVE C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------MGEQRNTSSKELAAAEATGQSGKE C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002138 ----------------------------------------------------------------------------MDEADRRLLWRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 ----------------------------------------------------------------------------MEERQRRALRRGRARLVAALRVEP--LWEPLEQRG-LFTRPMLE R_norvegicus_ENSRNOP00000017972 ----------------------------------------------------------------------------MEEADRQLLRRCRVRLVRELQVAE--LWDALLSRE-LFTRDMIE B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 ----------------------------------------------------------------------------MEEAQRSALRRGRVRLVEGLRPEV--LWGPLQARG-VFTSAMVE M_musculus_ENSMUSP00000030747 ----------------------------------------------------------------------------MDEADRQLLRRCRVRLVSELQVAE--LWDALLSRE-LFTRDMIE M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003205 ----------------------------------------------------------------------------MNEADRLLLRRYRVRLVGELQVAS--LWDALLSRE-LFTPDMIE C_intestinalis_ENSCINP00000002956 ---------------------------------------------------------------------------AMKKRHRNTLIKNRVKLAKCLHLDE--VLQYLVQCG-ILTDVTVE T_nigroviridis_ENSTNIP00000022078 ----------------------------------------------------------------------------------------------------------MAGEA-AGIPELGG G_aculeatus_ENSGACP00000005791 -----------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG--RNLSSVESASGLFSRLRDQGFLSAEQPHLLTELLIIIQRVRLTRDVDLPA--EPSSLISP--------YR B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 -----------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 -------------------------------------------------------------------------------------------------------SMQMAGEP-TEISDLGG M_mulatta_ENSMMUP00000040583 ----------------------------------------------------------------------------MDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFKPHMIE H_sapiens_ENSP00000365051 -----------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRLVEELQVDQ--LWDALLSRE-LFRPHMIE C_familiaris_ENSCAFP00000023986 ----------------------------------------------------------------------------MDEAERRALRRCRVRLVRELQVAA--LWDALLSRE-LFTAAMVE M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007585 --------------------------------------------------------MERSPGSGGRWECSGPPAPPELTPDVAELQSRVQETLELLSPQD--LRNFRLLLKTVDEEPRVS G_aculeatus_ENSGACP00000008661 -------------------------------------------------------------------------------------------------------QVNGA-RL-TSAQDVA- M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000024485 ------------------EFRLLLHQICEGLTGENVSMMKFLCKDAIPRSRELETALDFMEYFEAKGWIQEGDLGFLAEVLYRINRHDLLKLLPGVKNRR--DYEENFQAQ-QNNFTTYR C_familiaris_ENSCAFP00000016420 -------------------------------------------------------------------------------------------------------------MA-DDQDCGME G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010793 --------------------------------------------------------------------------------------------------------------------MDMA X_tropicalis_ENSXETP00000003217 ---------------------------------------------------------------------------------------------------------------------MEE D_rerio_ENSDARP00000063081 ---------------------------------------------------------------------------MSKKESTQRILQHKVFLIDTLSVEASFILQNVQQAKLITQRDY-- D_rerio_ENSDARP00000075650 ---------------------------------------------------------------------------MDKKESVDKICENKIFLLETLSVDANFILQHVQQAKLITLRDY-- A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 ----------------------------------------------------------------------------MLSTHKEKLRTNRHTLCKELVVDE--LLQELIGEG-IFNDILAD T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044662 ---------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILG--CNPAAVQSAGDLFSRLSDQDHLSEEQPHLLVELLGIIQRTKLLRDHNLPR--TGAQDLISP-YSCKS--R A_gambiae_AGAP004920-PA -----------------------------------------------------------------------------------------------------------VCGRDILHCKTMN D_rerio_ENSDARP00000019984 -----------------------------------------------------------------MDKEALTSENEVSGDDQENYGKGDVTDAKPDPKAM--CRVDKE-AL-TSEIEVLE M_domestica_ENSMODP00000032734 ----------------------------------------------------------------------------MLQPDMESFKAQVVSTLTKLSPEE--LRRFGIYLRNVGEEPRVS B_taurus_ENSBTAP00000012869 --------------------------------------------------------MEGSLGSGRRSGSDGQPAPPKISPTTEELQSRLQETLDLLSSQE--LRSFRDHLKKV--EPPVS E_caballus_ENSECAP00000021726 MTSQGQNLNSSSDDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSH-KKLEKSSSALEIFNHLLAEDLLREEDSFFLAELLYIIKQKSLLCHLCYTK--EQVESLLPA-RRRVSLFR B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 -------------------------------------------------------------------------------------------------------------MT-DDQDCAAE D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 -------------------------------------------------------------------------------------------------------------MT-DDQDCAAE A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000364878 HLIGKCLKFVVSNAENLVDDITETAQTAGKIFREHLWNSK-----KQLSS---------------------------------------------------------------------- P_troglodytes_ENSPTRP00000047678 HLIGKCLKFVVSNAENLVDDITETAQIAGKIFREHLWNSK-----KQLSS---------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000004372 HLIGTCLKFVVSNAENLVDDITQTAQIAGKIFREHLWNSK-----KQLSS---------------------------------------------------------------------- M_mulatta_ENSMMUP00000021744 ------------------------------------------------------------------------------------------------------------L----------- E_caballus_ENSECAP00000006810 RKLGKRVNRIVNGTENLVEDLSEKTEVAGKIFLKHLLKPK-----KQMNLKS-------LADYEDDESE-DT-----ESPFSSTESACEGEDEETEENAGLSQASVPPM----------- G_gorilla_ENSGGOP00000011776 HLIGKCLKFVLSNAENLVDDITETAQIAGKIFREHLWNSK-----KQLSS---------------------------------------------------------------------- C_familiaris_ENSCAFP00000021904 QTMGQTVNVITKKTENLVGDLTEKTQVVGKIFKDHFLNSG-----SLLSLSW-------SSTSATKPSGSCR-----PSYLTQARSRKKEEVPKILVFVIFLYKMVFL------------ M_musculus_ENSMUSP00000027009 LKIGESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQ-----EQLS-LQ-------FSNDEDDGPQ-KI-----CTPSSPSESKRKVEDDEMEVNAGLAHESHLML----------- R_norvegicus_ENSRNOP00000029448 LKIGEGASLILSKAENLVESFFEKTEMAGKIFAGHIANSD-----KQLSLLQ-------ADRNQITGPSFQI-----LVFNSLSESRGKVEDEEMEVNVGVAHASHLML----------- P_pygmaeus_ENSPPYP00000004373 EKKKYYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN--------------------------------------------------------- P_troglodytes_ENSPTRP00000041705 EKKKYYDAKTEDKVRVMADSIQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN--------------------------------------------------------- B_taurus_ENSBTAP00000027820 EKKKIYDAKLQDKARVLVDSIRQKNQEAGQVFVQTFLNID-----KNSTSIK-------APEE--------------------------------------------------------- C_familiaris_ENSCAFP00000031565 EKKTFYDAKPEDKPWVILNSVRQKRQEAGQALVHTFINTD-----KYSTSVE-------AFVE--------------------------------------------------------- H_sapiens_ENSP00000347741 EKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNID-----QISPNKK-------AHPN--------------------------------------------------------- M_mulatta_ENSMMUP00000012893 ----------------MADSIQEKQRMAGQMLLQTFFNID-----QISPSKK-------AHLN--------------------------------------------------------- E_caballus_ENSECAP00000010831 ERKKFYEAKPGDKPWVLVDSVRDRRHEAGQILWQALFNID-----RSVISRK-------ALEE--------------------------------------------------------- M_domestica_ENSMODP00000034020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034022 EIVREESKTNRDKARVLIDAVISKGPKASQCFTKSICERD-----GHLAEKL-------GLSSELNSNQSHI-----SLCREQAPRPINICILRNDN----------------------- M_mulatta_ENSMMUP00000012894 EKENYYNVKIEDKALILVDSVR-KNRVAHQRFTQTLLNMD-----QRITSVK-------SLLQ--------------------------------------------------------- P_troglodytes_ENSPTRP00000007279 EKKKYYDAKIEDKALILVDSLR-KNRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ--------------------------------------------------------- H_sapiens_ENSP00000376849 EKKKYYDTKIEDKALILVDSLR-KNRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ--------------------------------------------------------- E_caballus_ENSECAP00000021890 EKVRDENATVMDKARALIDAVIRKGPQACQIFIGHICEDD-----PHLAETL-------RLSSGPQSGNFLK-----TQDSQAVVHSSPALQAMP------------------------- H_sapiens_ENSP00000260309 EKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEED-----SYLAGTL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ------------------------- P_troglodytes_ENSPTRP00000059619 EKVKRENATAMDKTRALIDSVIPKGAQACQICITYICEED-----NYLAGTL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ------------------------- P_pygmaeus_ENSPPYP00000004374 EKKKYYNAKIEDKALILVDSVR-KNRVAHQIFIQTLLDMD-----QKITSVK-------PLLQ--------------------------------------------------------- M_domestica_ENSMODP00000034033 EILKEESRTIRDKARVLIDAIISKGPKASQCFTKSIWERD-----GHLAEKL-------GLSSGKRKYL--------LGKADHSIHGEKLKTKQRHT----------------------- G_gorilla_ENSGGOP00000015374 EKKKYYDAKIEDKALILVDSXR-KKRVAHQMFTQTLLNMD-----QKITSVK-------PLLQ--------------------------------------------------------- P_pygmaeus_ENSPPYP00000004377 EKVKRENATVMDKTRALLDSLIPKGARACEICITYICEED-----SYLAETL-------GLSADQTSGNYLN-----MQDSQGVLSSFPAPQAVQ------------------------- B_taurus_ENSBTAP00000027821 EKIRDENDTAMDRARVLIDTVIRKGPQACQICISHICEED-----SHLAGIL-------GLTSGSQSENYLR------QKPQAVVPPFPAPQAML------------------------- M_musculus_ENSMUSP00000027012 DKQKFNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVD-----PGSHHGE-------------------------------------------------------------------- R_norvegicus_ENSRNOP00000009993 DTIKLANITVMEKARDLCDHVTKKGPRASQMFITYICNED-----CYLAEIL-------ELQSGPSAETVFV-----TEDSKG-GHPFSSETKEK------------------------- M_musculus_ENSMUSP00000027015 DKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNED-----CYLAGIL-------ELQSAPSAETFVA-----TEDSKG-GHPSSSETKEE------------------------- O_anatinus_ENSOANP00000016591 DTVREEHHRPAEKTRALLNSVIPKGDLASQIFIDSLCKKN-----PFVAAKL-------GLSAGGQGQSGNTQFVGQSQMIPAVATSCSVPQALQAP----------------------- O_cuniculus_ENSOCUP00000000956 EKVRVENATVMDKARALLDCVIRKGPQACQICINHICEDD-----CHLAGLL-------GLSSGPQSENHFN-----AQDSLEAFSSFSAPQTTQ------------------------- R_norvegicus_ENSRNOP00000058685 EKQKFNNAERSDKRWVFVDVLKRKHNQVGKMLLQTFLNVD-----SGSHHGE-------------------------------------------------------------------- M_mulatta_ENSMMUP00000012901 --------------------------------------------------------------------------------------------AMQ------------------------- G_gallus_ENSGALP00000001569 DEVQEGNPVTTDKARSLIDTVRLKGPRASAIFIDSLRKHD-----CNLAEQL-------RLCAHAEPPGAPLAAPSTVGFSDP------------------------------------- X_tropicalis_ENSXETP00000017024 EYINECNAITKDRCRRMIDNIKNKGDYSSNILLQCLVENH-----KTLAKNM-------GLD-----------------VSEPAIAPQPIQ----------------------------- G_aculeatus_ENSGACP00000013201 DSILEENGTKADRARNLIDVVKAKGNKASEILIASLESRD-----SSLFSEL-------GLS-----------------SAQTAPPAISGVSNIFKL----------------------- A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006490 KREKFYDAKTHKKAQILVDSLREKCHEEDQKLTETFLNID-----QNSTGMQ-------XXXX--------------------------------------------------------- D_rerio_ENSDARP00000034228 KSTIEKLKDEIDLVDLLVNTFTSDAVSVTVDILRGIKCNAVA---EELLENT-------GQVYSIF----------KLCKKNSHYTKPPIIITDVFMFCFLGGVSQPEPPVP-------- T_rubripes_ENSTRUP00000019853 ESITEESNIRSDKARRLIDSVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPP--------GELRDDTLFQTDRIVSFRF------- T_rubripes_ENSTRUP00000035020 ESITEESNIRSDKARRLIDSVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPPVFNRRAPDGRSR-------VIFNSPINRC----- O_latipes_ENSORLP00000007938 ESICEEKS-RADMARSLIDTVRKKGSTASKMMINHFEQKD-----PILFSEL-------GLS-----------------CPEPAQT---------------------------------- T_rubripes_ENSTRUP00000013027 ESITEESNIRSDKARRLIDLVRKKGERACKKMISHIQSRD-----PELSAVL-------GLS-----------------CGHPAPP--------GELR-------GQLESPAF------- D_rerio_ENSDARP00000059407 EAIPRGKLENKDRQDVVDYMVQHYSMDAGKIAVQALRSIKQNERANRLESKL-------LEAVSSS----------DLFQPQAQENEQNPEDPQSIN----------------------- D_rerio_ENSDARP00000068268 EPIPRGKLENKDRQDVVDSMVQQYSEDAGTITVQTLRKIKQNERAKRLESNL-------LKV-----------------QSQGQENKQNSEEPQPIPQIISQPIQQIISQPINNAGSE-- D_rerio_ENSDARP00000008601 NSEVQLSNELVDFAVELTCGHRMPVDYVVAWFKCYLKQKETDFSCPHFIVDQ-------GKTCGAK----------LSYQEICQLIPLSDKQREFLEENLAAIVARRLFDFKSCPGCQSH C_elegans_C48D1.2 MINS--CGTVREKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEV-LEPL-------ARSVDSN----------AVEFECPMSPASHRRSRALSPAGYTSPTRVHRDSVSSVSSFTSY G_gallus_ENSGALP00000029853 MIQA--KSGSFSQNVEFLNLLPKRGPNAFSAFCEALQETKQQHLAEMILKTE-------SS--LRH----------G----IAT-----------------LEQR----YGSNLPLP-LS A_carolinensis_ENSACAP00000006831 MIQA--KAGNFSQNIEFLNLLPKRGPKAFSAFCEALRETKQPHLEEMLLLNL-------IDFLLFH----------HVI--VPP-------------------------QNAHLPLHTVC D_rerio_ENSDARP00000075318 EDIQHRMKTRADQARHVIDDVKRKGVKASEIMLASLKTRDPHLYDTLGIERL-------LVPVPET----------ELTPSQLSETTGCST----------------------------- X_tropicalis_ENSXETP00000015203 TIMA--HRSEYKQNVTLLTQLPKRGPRAFSEFCNALHATGQRHLAEQLEEEA-------QQQQMES----------V----TPE--------------------V----HERSFPLP-VQ M_musculus_ENSMUSP00000031895 LIQA--KGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTL-------SD--IQH----------V----LPP-----------------LSCD----YDTSLPFS-VC R_norvegicus_ENSRNOP00000022672 LIQA--KGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTL-------SD--IQH----------I----LPP-----------------LSCD----YDSSLPFS-VC E_caballus_ENSECAP00000003321 LIQA--KVTSFGQNVELLNLLPKRGPQAFEAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC B_taurus_ENSBTAP00000024166 HIQA--KTGSFGQNVELLNLLPKRGPQAFDAFCVALRETKQSHLEELLLRTL-------SG--LQP----------V----VPP-----------------LSCD----YDLSLPFP-VC O_anatinus_ENSOANP00000005545 LIQA--KAGSFSQNVEFLNLLPKRGPKAFDAFCAALRETKQGHLQDLLYRTL-------SN--LS-----------------PPSTAVGALGTQGEELAGRLGGR----WRGLPSLP-SV H_sapiens_ENSP00000312664 LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC P_troglodytes_ENSPTRP00000033921 LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC P_pygmaeus_ENSPPYP00000017020 ----MENTENSVDSKS----IKNLE---PKVIHGSKSMDS-------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000016588 LIQA--KVGSFSQNVELLNLLPKR-PQAFDAFCEALRETKQGHLEDIELKLR-------VS--ALM----------K----PTG-----------------LGSD----YNDILGLM-VK O_anatinus_ENSOANP00000000517 ----AASGEVMVDSKS----FHSSQGYSSRKVPGKQFLGS-------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000037606 SIMA--EQTSQKRSWRLQLLLPKRGPKAFSSFCSALRATDQQHLCDLLTQTF-------ET--NGN------------------------------------GTHVETCVDSSVPLP-TQ C_familiaris_ENSCAFP00000005409 HIQA--KVGGFSQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------G----LPP-----------------LSCD----YDLSLTFP-MC E_caballus_ENSECAP00000019797 ----MENSKISVDSKS----IKNSE---TKILHGSKSMDS-------------------------------------------------------------------------------- T_guttata_ENSTGUP00000013612 MIQA--KSGSFDRNVEFLNLLPKRGPNAFSAFCEALRETQQQHLETLILKTM-------SS--LSQ----------E----IAR-----------------LEHC----HESDLPYP-AS P_troglodytes_ENSPTRP00000054330 ----MENTENSVDSKS----IKNLE---PKIIHGSQSMDS-------------------------------------------------------------------------------- H_sapiens_ENSP00000311032 ----MENTENSVDSKS----IKNLE---PKIIHGSESMDS-------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000020323 LIQA--KVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC E_caballus_ENSECAP00000010379 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ----MENTENSVDSKS----IKSLE---PKIIHGSKSVDS-------------------------------------------------------------------------------- O_latipes_ENSORLP00000015114 SIMV--QKTSHHRSFKLLLLLPKRGPRAFKSFCSALKETEQEHLCDLLTQ---------EE--EGR----------EVCLDTPL-----------------INSEEQSEVSSSMSYP-IH G_aculeatus_ENSGACP00000013740 NIMA--EQTSQKRSWRLLLLLPKRGPRAFSSFCSALQETEQQHLYELLIQSS-------EK--DGK----------E----TPG-----------------MLMCGQF-IDSSLPLP-TQ O_cuniculus_ENSOCUP00000001859 LIQA--RVGSFSQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTL-------SG--LQH----------V----LPP-----------------LSCD----YDLSLPFP-VC M_domestica_ENSMODP00000001598 LIQA--KVGSFSQNVEFLNLLPKRGPHAFEAFCDALRETKQGHLEDLLHRTL-------YS--FQN----------L----RPP-----------------LGCD----YDSSFPLP-VC T_nigroviridis_ENSTNIP00000009934 SANGPASGEDFTDASK---GGEQPSGSSSS---GKMTVDA-------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000040691 SANGPSPGGDFTDAKK--GAGQQPRSGSSS---GRVTVDA-------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000010874 SILA--EQTSHKRCWKLLHLLPKRGPKAFSSFCSALRETDQKHLCDLLARTS-------QE--NGN------------------------------------GTHLETCVDSSVPLP-TQ T_guttata_ENSTGUP00000006879 IGDGAHLGKDLADTKS----IPGFK---GKNLPASKSMDS-------------------------------------------------------------------------------- D_rerio_ENSDARP00000083664 SIMA--KPTSQGRSHQLLFLLPKRGPRAFSTFCSALKETEQHHLCKLLMDFT-------EK--DKK----------N----SQY-----------------KL---------------SP G_aculeatus_ENSGACP00000024809 --------------------------------MDKLYRDV-------------------------------------------------------------------------------- M_domestica_ENSMODP00000004412 DIQR--AGTRRDQARQLVTDLQTRGKRALPIFISCLEATGQWDLAALLSESN-------TTLTQQP----------DPIDIKPVEMIRSGGLRSTGRYTSMVSLH-------LLLLANSP G_gallus_ENSGALP00000017288 IKDGPRSGEDVSDARS----FPGSK---GMNLPASKSVDS-------------------------------------------------------------------------------- E_caballus_ENSECAP00000015102 DIQR--SGSRRDQARQLIIDLETRGSQALLLFISCLEDTGQDTLASFLRTSS-------QAAKQNP------------EAIRPSD-LPPVVLGPVGLKPEELTAV--------KQDPSKL E_caballus_ENSECAP00000013731 QGAGDSTSTDAVDAKP----DRSSFVPSLFS-KKKKNGPE--------RSIT--------TN---------------------------------------------------------- C_familiaris_ENSCAFP00000032189 LEVSMENTENSVDAKS----FKNAE---TVIV---KILKD-------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ----MDNNETSVDSKS----INNFE---TKTIHGSKSMDS-------------------------------------------------------------------------------- M_domestica_ENSMODP00000005556 ----MEDTGTTVDAKS----TKNSG---VKLFHGSKSVES-------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 -MASNRPGEDSTDARK----DNGELAAGASPAPDRMDVDG-------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000002138 DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 -MSVNGPGEDRTDAKT----EQSEVSSSAS---APEEVDA-------------------------------------------------------------------------------- T_guttata_ENSTGUP00000017449 ELQS--AGSRGEQARQLIIDLETRGKQAFPAFLSILRDTGQGHLAEMLMQEC-------ESRPVPP----------QLPDLRPVEL---------------------------------- R_norvegicus_ENSRNOP00000017972 DIQRAGSGSRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSSG-------QAAKQDP------------EAVTPLDHLVPVVLGPMGLKSKEQKVV--------KLDPSQP B_taurus_ENSBTAP00000028116 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 DMQS--TGTRREQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEGC-------GSPMSPP------------VDLRPVQLELPGERRD-------------------------- M_musculus_ENSMUSP00000030747 DIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGR-------QAAKQDP------------EAVKPLDHLVPVVLGPMGLTAKEQRVV--------KLDPSQP M_musculus_ENSMUSP00000091238 ----MENNKTSVDSKS----INNFE---VKTIHGSKSVDS-------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000035938 -------------------------------STKKKKTEDPE---KPPQASD--------NV---------------------------------------------------------- O_anatinus_ENSOANP00000015596 ------AGTRRDQARQLVTDLETRGRRALSVFISCLRETDQHALAALLSEGC-------QAPQVTP------------VDIRPVEIIRPGGQGDVCKYSKIHPKC------------YSP B_taurus_ENSBTAP00000003205 DIQRAGSGSRRDQARQLILDLETRGSQALPLFISCLEDTGQDTLASLLKTSR-------QAAKQ-----------------------------------------------------SKP C_intestinalis_ENSCINP00000002956 RITS--KPTRFSQNVAFLTCLPTRGPRAYGTFLEALRISSQEHLVDILEKVD-------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022078 EAEGEHRCEDDVDAKP----DRRGRFLLFKS-KKKNDGQMRE---QDYCSES--------HY---------------------------------------------------------- G_aculeatus_ENSGACP00000005791 KMLYNLSEELTADDLKDMKFLLHSYLPRRKLEENVSTLEIWL---EMEHKDL-------MNEHNLH----------LLEILISKVCPMLKDKINQLKAQQETPTSPATQESGRQGSLSA- B_taurus_ENSBTAP00000021099 ----MENTENSVDSKS----IKTSE---TKILHGSKSMDS-------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000056642 DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP D_rerio_ENSDARP00000006831 ------MNGDCVDAKRVDTTDASKDGASAS---QPMQVDA-------------------------------------------------------------------------------- H_sapiens_ENSP00000221740 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 MSDVKPKGVDTVDARQ----SDAKESSSVTD-PGLVQMDA-------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000031759 EVEEGGQSEDDVDAKP----DRKGRFLLFKS-KKNKDGQMRE---QDYCSES--------HY---------------------------------------------------------- M_mulatta_ENSMMUP00000040583 DIQRAGSGSRRDQARQLITDLETRGSQALPSFISCLVDTGQDMLASFLRTNR-------QAVKL-----------------------------------------------------SKP H_sapiens_ENSP00000365051 DIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNR-------QAAKL-----------------------------------------------------SKP C_familiaris_ENSCAFP00000023986 DLQHAGSGSRSDQARQLVIDLETRGSQALPLFISCLEDTGQDALASCLTMSR-------QAVKQNP------------EATRPLD-LMPVVLGPTRLTPEDLR----------GKDPSKL M_mulatta_ENSMMUP00000024183 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007585 PVKLELEGRKKAGLARLVAQNYCEPA-ASRVLVKVLRQLRRADLLRLW--QG-------AADRGGE----------RIPRKILK------------------------------------ G_aculeatus_ENSGACP00000008661 -AEEGGPTGDQTDAKP----DRRGRFLLFGNIKKNKDGQTRE---QDYSSES--------HY---------------------------------------------------------- M_domestica_ENSMODP00000018104 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005560 ----MEDTGTTVDAKS----IKNSG---VKSLHSSKSVES-------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000024485 VVCFMLADELTEGDLKILKRLCAGKMSKANVRRSVDVLSWLT---CMEEEDL-------LSEGDLD----------FIMSILQHLDNQKPYKLFQRVRMNDNTVTLPKNQQKSNAFQPNS C_familiaris_ENSCAFP00000016420 QAAGDSESPDAVDARP----DRSSFVPSLFS-RKKKNDSG--------RSIK--------TA---------------------------------------------------------- G_gallus_ENSGALP00000014503 ---------------------------------KKKNGEEEQ---PKSSLSN--------QY---------------------------------------------------------- R_norvegicus_ENSRNOP00000009643 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ---------------------------------KKKNGEEEQ---PKPSLSN--------QY---------------------------------------------------------- O_latipes_ENSORLP00000010793 ETAEELSGKDQVDTKP----VISKRSPANQ--PNPRSTDV-------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003217 SHNGVQYGEDTADAKT----YFTNQQISLQNCDIKDMEKK-------------------------------------------------------------------------------- D_rerio_ENSDARP00000063081 -NNLSDVSERETKIIKLLDKLIGRGEETCQEFIDLLRQDCVLENFPVLEGHA-------IFA---------------------------------------------------------- D_rerio_ENSDARP00000075650 -NNLSDFPQRETKIINLLDKLMGKGEETCHQFIALLRQDCVLENFPMLKDHD-------IFD---------------------------------------------------------- A_carolinensis_ENSACAP00000002670 -------------------------------IPVSKSVDS-------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000023055 ------MSDTTGDGRGGRVASPNKAATDRAACTENLTETD-------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000007986 RVLS--HQRDFKKNVEFLTLLPGRGPNAFNAFRIALINSDQSHLAELLDPAQGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGTSAPLSRRRPMENTDQSSTSIASSQVI T_guttata_ENSTGUP00000004278 ------MSGSERRPPAGHVQLDSRPTLPTTDGNENITEVDA------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000044662 KLLYSLSEELTADDLKDIKFLLNNKLPRGKLEE-VTTLEVFM---ELEHRAL-------ISDTDLG----------FLESIIQPVCPVLLEKINQFNA----------QNCKMHLILHIF A_gambiae_AGAP004920-PA TSTLSTAFDEVDNNTRVLSLVASVPEIISSSVIHELEPV--------------------------------------------------------------------------------- D_rerio_ENSDARP00000019984 EDQDSYGEEDVTDAKP----DRKGRFRLFGN-FKKNDGKLQE---KG-ESES--------HY---------------------------------------------------------- M_domestica_ENSMODP00000032734 RHDLEM-ATKPEELADLLLKRYVMTG-TPRVLVQVLGQVPRKDLALEWALRR-------RSPSRCK----------SMSRMNLK------------------------------------ B_taurus_ENSBTAP00000012869 QVKLELEGHSPSGLAKLLAKHYYPAAVAKRVLVQVLELLPRADLLPRW---Q-------SAPTDCP----------VIPRKSLK------------------------------------ E_caballus_ENSECAP00000021726 NLLYELSEGMDSDNLNSMMFLLKDSIPKTQ----MTSLSLLA---HLEKQAR-------IDEDNLT----------LLEMLCKNVVPNLMRKIEKYKR----------EKAAQVVTAPVD B_taurus_ENSBTAP00000008706 ------------------------------S-KKKKNDSG--------KSVN--------IP---------------------------------------------------------- M_musculus_ENSMUSP00000026062 LEKVDSSSEDGVDAKP----DRSSIISSILL-KKKRNASA--------GPVR--------TG---------------------------------------------------------- D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013788 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005488 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 LEMADSSTEDGVDAKP----DRSTIISSLLW-KKKKNASM--------CPVS--------TT---------------------------------------------------------- A_gambiae_AGAP011949-PA ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000364878 --------------------------------------------------------------------------------------------------------------DISSD-GER- P_troglodytes_ENSPTRP00000047678 --------------------------------------------------------------------------------------------------------------DISSD-GER- P_pygmaeus_ENSPPYP00000004372 --------------------------------------------------------------------------------------------------------------DISSD-GER- M_mulatta_ENSMMUP00000021744 --------------------------------------------------------SAPLE--IQGAQPSGRLK----------------LCPHAH----FRELKTKRADEIYPV-MEKE E_caballus_ENSECAP00000006810 --------------------------------------------------------TDPQE--TQVSQPKDKLK----------------PCSHDH----FRKLKTTKAEEMYPV-MEKK G_gorilla_ENSGGOP00000011776 --------------------------------------------------------------------------------------------------------------DISSD-GER- C_familiaris_ENSCAFP00000021904 --------------------------------------------------------LQVLQ--EIQASQVKVRK----------------LCPCDH----SHEPKITNVHEIYPV-MEKE M_musculus_ENSMUSP00000027009 --------------------------------------------------------TAPHG--LQSSEVQDTLK----------------LCPRDQ----FCKIKTERAKEIYPV-MEKE R_norvegicus_ENSRNOP00000029448 --------------------------------------------------------TVPQG--IQSTEVQDSLK----------------LCSRDW----FCTMKTERAEEIYPV-MEKE P_pygmaeus_ENSPPYP00000004373 --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN P_troglodytes_ENSPTRP00000041705 --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN B_taurus_ENSBTAP00000027820 --------------------------------------------------------TVAGP--DESVGSAATLK----------------LCPHEE----FLKLCKERAGEIYPI-KERK C_familiaris_ENSCAFP00000031565 --------------------------------------------------------NMPGPTIPDSEESTDTLK----------------LCPPET----FVKMYKEKAEEIYPI-KERK H_sapiens_ENSP00000347741 --------------------------------------------------------MEAGP--PESGESTDALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN M_mulatta_ENSMMUP00000012893 --------------------------------------------------------MEARP--PESGESADALK----------------LCPHEE----FLRLCKERAEEIYPI-KERN E_caballus_ENSECAP00000010831 --------------------------------------------------------IAAGP--AESAEPTDTLK----------------LCPHEE----YLRLCKERAEEIYPI-KDKK M_domestica_ENSMODP00000034020 ---------------------------------------------------------LIAS--TAQTGSSGKLK----------------VCSREE----FLMQRRLRVEEIYPV-MEKG M_domestica_ENSMODP00000034022 --------------------------------------------------------IERT---TMNPGYLDTLK----------------LCSYED----FQQKRKEMEGQIYPV-MEKG M_mulatta_ENSMMUP00000012894 --------------------------------------------------------IEAGP--PESAESTNTLI----------------LCPHEE----FLRRCKENHDEIYPI-KKRE P_troglodytes_ENSPTRP00000007279 --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE H_sapiens_ENSP00000376849 --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE E_caballus_ENSECAP00000021890 --------------------------------------------------------DDLAK--LALSGPKVSLK----------------LCSPEV----VERIWKEKSAEMYPI-MGKS H_sapiens_ENSP00000260309 --------------------------------------------------------DNPAM--PTSSGSEGNVK----------------LCSLEE----AQRIWKQKSAEIYPI-MDKS P_troglodytes_ENSPTRP00000059619 --------------------------------------------------------DNPAM--PTSSGSEGNVK----------------LCSLEE----AQRIWKEKSAEIYPI-MDKS P_pygmaeus_ENSPPYP00000004374 --------------------------------------------------------IEAGP--PESAESTNTLK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE M_domestica_ENSMODP00000034033 --------------------------------------------------------IGKWK--VIHDDAIDTLK----------------LCSYAD----FQRIKKEKEGQIYPV-MEKG G_gorilla_ENSGGOP00000015374 --------------------------------------------------------IEAGP--PESAESTNILK----------------LCPREE----FLRLCKKNHDEIYPI-KKRE P_pygmaeus_ENSPPYP00000004377 --------------------------------------------------------DNPAM--PTSSGSKGNVK----------------LCSLKE----AQKIWKEKPAEIYPI-MDKS B_taurus_ENSBTAP00000027821 --------------------------------------------------------DNPVK--LASSGPGGNLK----------------LCPPET----AQRIRKEKSGEIYPI-MERS M_musculus_ENSMUSP00000027012 --------------------------------------------------------ANLEM--EEPEESLNTLK----------------LCSPEE----FTRLCREKTQEIYPI-KEAN R_norvegicus_ENSRNOP00000009993 --------------------------------------------------------LNKEG--GAFPGPSGSLK----------------FCPLEI----AQKLWKENHSEIYPI-MKTP M_musculus_ENSMUSP00000027015 --------------------------------------------------------QNKED--GTFPGLTGTLK----------------FCPLEK----AQKLWKENPSEIYPI-MNTT O_anatinus_ENSOANP00000016591 --------------------------------------------------------KTLTE--SHPDGSGEILK----------------LCPSEE----REKLQKENEGEIYPV-LVKA O_cuniculus_ENSOCUP00000000956 --------------------------------------------------------DNQVV--FTFSGP--SLK----------------LCPLET----AQRIWKEKSEEIYPIKMQSS R_norvegicus_ENSRNOP00000058685 --------------------------------------------------------ANLEM--EEPEESVDTLK----------------LCSSEE----FTRLCREKKQEIYPI-KETN M_mulatta_ENSMMUP00000012901 --------------------------------------------------------DNPAM--PTSSGSKGNVK----------------LCSQEE----AQRIWKEKPAEIYPI-MVKS G_gallus_ENSGALP00000001569 ---------------------------------------------------------------PVSSQDLQWIQ----------------QCPLSE----YQRIKEAEGDQIYDIYQPRE X_tropicalis_ENSXETP00000017024 --------------------------------------------------------EQNKK--TNENTEISSVI----------------HCSDKD----FKEIHDTQGDKIYEM-RKRE G_aculeatus_ENSGACP00000013201 ------------------------------------------------------------------------------------------VSPHRD----RKLTPLKSVFQIYPA-SKNS A_carolinensis_ENSACAP00000013361 ------------------------------------------------------------------------------------------------------------AMQIYPI-GDRR O_cuniculus_ENSOCUP00000006490 --------------------------------------------------------XXXXX--XXXXXXXXXXX----------------XXXXXX----XXXXXXXXXXXIYPI-KDKK D_rerio_ENSDARP00000034228 --------------------------------------------------------EPIPK--DPAQLKELKVT----------------PCSQQF----KNKILREKGQETYEI-KDKS T_rubripes_ENSTRUP00000019853 -----------------------------------------------------------QP--QSPRWKVKGHL----------------QLPHQS----MCSGRRNRATKVYPG-TREA T_rubripes_ENSTRUP00000035020 --------------------------------------------------------VLEGE--TERQRRERALK----------------ISP-GN----HSLLLQSFQ--VYPG-TREA O_latipes_ENSORLP00000007938 ------------------------------------------------------------N--SHSQRDEPATT----------------VLTAED-----FWKKTQNDPNVYPV-TKAS T_rubripes_ENSTRUP00000013027 -----------------------------------------------------------ST--AEPQMEGQGSS----------------STP-PS----IDVFWKEKQSDVYPG-TREA D_rerio_ENSDARP00000059407 -------------------------------------------------------------------------T----------------SGFQEF----KTRLLYANRDDIYTP-VSRT D_rerio_ENSDARP00000068268 --------------------------------------------------------DLQPI--QADWQRPRQII----------------PCSQET----KNTLLKAHGDDIYTP-RSGT D_rerio_ENSDARP00000008601 VERRNRNNLCVKCTICTANMTQTYYFCWKCRREWKGVTNNAECC------------GNTGC--GQSVTEPDPLK----------------PCTPEF----KAEKLMTEGKCIYPV-KDKS C_elegans_C48D1.2 QDIYSRARSRSRSRALHSSDRHNYSSPPVNAFPSQPSSANSSFTGCSSLGYSSS--RNRSF--SKASGPTQYIF----------------HEEDMNFVDAPTISRVFDEKTMYRN---FS G_gallus_ENSGALP00000029853 ESCN------------SKRPRLIV--FFCTKPV-----------------------EHSLD--SGDGPPIPPVK----------------HCTPEF----YRDHQ----HLAYKL---IS A_carolinensis_ENSACAP00000006831 DLLP------------FAYQLFIS----SAEPM-----------------------EHSLD--DGDGPHYPQVM----------------PCTPEF----YRTHE----QLAYKL---KS D_rerio_ENSDARP00000075318 ----------------------------------------------------------------------------------------------------DKTNT---M-NEYEM---KS X_tropicalis_ENSXETP00000015203 ESTP------------SRPRRQFC-----REYN-----------------------EESID--DGDGPGTVQL------------------CSVDF----YLSHH----QQAYKM---HS M_musculus_ENSMUSP00000031895 ESCP------------PHKQLRLS-----TDAT-----------------------EHSLD--NGDGPPCLLVK----------------PCTPEF----YQAHY----QLAYRL---QS R_norvegicus_ENSRNOP00000022672 ESCP------------PHKQSRLS-----TDTM-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQAHY----QLAYRL---QS E_caballus_ENSECAP00000003321 ESCP------------PHKQLRLS-----TDTV-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQAHY----QLAYRL---QS B_taurus_ENSBTAP00000024166 ESCT------------RHKRLHLS-----PDAV-----------------------EHSLD--HGDGPPCLQVK----------------PCTPEF----YQTHH----HLAYRL---QS O_anatinus_ENSOANP00000005545 SVCPVVVCPFLMVLGNSRLQPALSVGDLLPEEM-----------------------EHSLD--NGDGPPCPQVK----------------PCTPEF----YRVHH----HLAYRL---ES H_sapiens_ENSP00000312664 ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS P_troglodytes_ENSPTRP00000033921 ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS P_pygmaeus_ENSPPYP00000017020 -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY M_mulatta_ENSMMUP00000016588 LNT-------------VFWFSVYT-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS O_anatinus_ENSOANP00000000517 -----------------------------------------------------------------------------------------------------SASL---D-DRYRM---DY T_rubripes_ENSTRUP00000037606 EAVP------------GVCVCVCE-----TESL-----------------------EVSLD---ADSPINTPVL----------------PCTPDF----YLSHF----QQSYKM---AS C_familiaris_ENSCAFP00000005409 ESCP------------PQKQLRLS-----PDTV-----------------------EHSLD--NGDGPPCLQVK----------------PCTPEF----YQTHY----QLAYRL---QS E_caballus_ENSECAP00000019797 -----------------------------------------------------------------------------------------------------GISL---D-SSYKM---DY T_guttata_ENSTGUP00000013612 ESCN------------SKRPRWL-------EPM-----------------------EHSLD--NRDGPSIPPVK----------------YCTPEF----YHNHQ----HLAYKL---TS P_troglodytes_ENSPTRP00000054330 -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY H_sapiens_ENSP00000311032 -----------------------------------------------------------------------------------------------------GISL---D-NSYKM---DY P_pygmaeus_ENSPPYP00000020323 ESCP------------LYKKLRLS-----TDTV-----------------------EHSLD--NKDGPVCLQVK----------------PCTPEF----YQTHF----QLAYRL---QS E_caballus_ENSECAP00000010379 -------------------------------------------------------------------------------------------------------------QEAYDM---SG M_mulatta_ENSMMUP00000015808 -----------------------------------------------------------------------------------------------------GISL---E-NSYKM---DY O_latipes_ENSORLP00000015114 DSEG------------LQLEMRTN-----TESM-----------------------ESSLD---ADSPINTPVL----------------ACSADF----YLSHC----QQSYRM---NS G_aculeatus_ENSGACP00000013740 EVVA------------AKRART-Q-----AESM-----------------------EFSLD---ADSPINSPVL----------------PCTPDF----YLSHC----HQSYRM---NS O_cuniculus_ENSOCUP00000001859 ESCS------------PHKQPRLS-----TETE-----------------------ERSLD--NGDGPPCLQVK----------------PCTPEF----YQTHY----QLAYRL---QS M_domestica_ENSMODP00000001598 DSCP------------PHKQLRLS-----VETM-----------------------EHSLD--NGDGPPSLQVK----------------PCTPEF----YQTHQ----HLAYRL---QS T_nigroviridis_ENSTNIP00000009934 ----------------------------------------------------------------------------------------------------KSARY---S-FRYSL---DF T_rubripes_ENSTRUP00000040691 ----------------------------------------------------------------------------------------------------KPAAY---S-FRYSL---DF T_nigroviridis_ENSTNIP00000010874 EAVP------------AKRART-------QESM-----------------------EISLD---ADSPINTPVC----------------PCTPDF----YHSHS----QQSYKM---TS T_guttata_ENSTGUP00000006879 -----------------------------------------------------------------------------------------------------GILP---D-YSYRM---DY D_rerio_ENSDARP00000083664 EICK------------KKNKHTHT-----HKSM-----------------------EMCLD---ADSPVTTAVL----------------PCTPEF----YQSHR----PQAYPM---RS G_aculeatus_ENSGACP00000024809 ----------------------------------------------------------------------------------------------------QSGED---K-YRYKM---DY M_domestica_ENSMODP00000004412 FLYFIDAVLVSAHNLFPLELIKR--QPTFSKVLSLLYKLRFPF------------------------------------------------CPPPQ------------VGQVYTL---NS G_gallus_ENSGALP00000017288 -----------------------------------------------------------------------------------------------------GILP---D-DSYRM---DY E_caballus_ENSECAP00000015102 TPGKLTPVVLGPEELWLAKLRPEVLRPEVPRPVDIGSGGFSDV------------------------------------------------RAQDR----LRGNA----DLAYVL---NA E_caballus_ENSECAP00000013731 ----------------------------------------------------------------------------------------------------RNREP---T-YQYNM---NF C_familiaris_ENSCAFP00000032189 -----------------------------------------------------------------------------------------------------KYLT---K-LHYKM---DY C_familiaris_ENSCAFP00000023821 ------------------------------------------------------------------------------------------------MVDSEIRQAQLLAQEAYDM---SG R_norvegicus_ENSRNOP00000014096 -----------------------------------------------------------------------------------------------------GIYL---D-SSYKM---DY M_domestica_ENSMODP00000005556 -----------------------------------------------------------------------------------------------------GLS----S-DSYKM---DY G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------DKYRYKM---DY O_latipes_ENSORLP00000010095 ----------------------------------------------------------------------------------------------------KPSSH---S-FRYSL---NF P_pygmaeus_ENSPPYP00000002138 TLENLTPVVLRPEIVRPEIRKPEVLRPETPRPVDIGSGGFGDV------------------------------------------------GALES----MRGNA----DLAYIL---SM G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002346 --------------------------------------------------------------------------------------------------------------ERYDM---SG G_aculeatus_ENSGACP00000022402 ----------------------------------------------------------------------------------------------------KPNVH---S-FRYSL---SF T_guttata_ENSTGUP00000017449 -------------ELQEANQRCAVVLQTAAR--DVAAGIPLTV------------------------------------------------GKSPE----VMSFI----ILDYEM---KA R_norvegicus_ENSRNOP00000017972 ALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDV------------------------------------------------CTPGK----IERHA----DMAYTL---DS B_taurus_ENSBTAP00000028116 -------------------------------------------------------------------------------------------------ESKEMSSPQPLEEETYDM---SG G_gallus_ENSGALP00000002083 -------------KSVSTAERLSIPVQPESERFRMPP------------------------------------------------------APAQACPTGLAGEC----SEVYQL---RA M_musculus_ENSMUSP00000030747 AVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDV------------------------------------------------CVPGK----IRGHA----DMAYTL---DS M_musculus_ENSMUSP00000091238 -----------------------------------------------------------------------------------------------------GIYL---D-SSYKM---DY X_tropicalis_ENSXETP00000035938 ----------------------------------------------------------------------------------------------------RIVTP---A-FQYKM---NY O_anatinus_ENSOANP00000015596 PLPFQSTSPLRGKEQWTGSVKPFVPVPSTTKREQEA-------------------------------------------------------TRPGE----KQGMA----IKVYSL---KS B_taurus_ENSBTAP00000003205 SQGKLAPVVLGPEELWPAKLRPEVLRPEVPRAVDAGSGGFTDV------------------------------------------------CPQDR----AKGNA----DLAYVL---NA C_intestinalis_ENSCINP00000002956 ---------------ISNAIPNNKPITPTTLHATITSNVHSEFVCARRQPMEIGKCEDKND--AKDGHNRLRVQ----------------NSTVAF----FNETY----NSGYKM---TT T_nigroviridis_ENSTNIP00000022078 ----------------------------------------------------------------------------------------------------RIVSP---T-FQYRM---SH G_aculeatus_ENSGACP00000005791 PNAPNQVPQSLGAEGTGLFEMQDSPSGFNGGGDCAALSLGLSGHLKIEV-------VETMP--PPKNMSCSEPP----------------TSQPSD----TNTEV---L-GTYPM---TS B_taurus_ENSBTAP00000021099 -----------------------------------------------------------------------------------------------------GISL---E-ESYKM---DY P_troglodytes_ENSPTRP00000056642 TLENLTPVVL-----RPEIRKPEVLRPETPRPVDIGSGGFGDV------------------------------------------------GALES----LRGNA----DLAYIL---SM D_rerio_ENSDARP00000006831 ----------------------------------------------------------------------------------------------------KPQSH---A-FRYSL---NY H_sapiens_ENSP00000221740 -----------------------------------------------------------------------------------------------------MSNPRSLEEEKYDM---SG D_rerio_ENSDARP00000071815 ----------------------------------------------------------------------------------------------------KSHSDDNVD-YQYKT---NY T_rubripes_ENSTRUP00000031759 ----------------------------------------------------------------------------------------------------RIVSP---T-FQYKM---SH M_mulatta_ENSMMUP00000040583 TLENLTPVVL-----RPEIRKPEVLRPETPRPVDIGSGGCGDV------------------------------------------------GAPES----LRGNA----DLAYVL---SM H_sapiens_ENSP00000365051 TLENLTPVVL-----RPEIRKPEVLRPETPRPVDIGSGGFGDV------------------------------------------------GALES----LRGNA----DLAYIL---SM C_familiaris_ENSCAFP00000023986 TPGKLAPVVLG-----PAELQPQVVRPSVPRPTDNGSGRFSDV------------------------------------------------CEYQESGWWVAGPI----KLAYAL---NA M_mulatta_ENSMMUP00000024183 -----------------------------------------------------------------------------------------------------MSNLRSSEEEKYDM---SG C_familiaris_ENSCAFP00000007585 ----------------------------------------------------------------------------------------------------RSYDCVDGELDRYDL---SG G_aculeatus_ENSGACP00000008661 ----------------------------------------------------------------------------------------------------RVVSP---T-FQYKM---SH M_domestica_ENSMODP00000018104 --------------------------------------------------------------------------------------------------------------DVYNM---SD M_domestica_ENSMODP00000005560 -----------------------------------------------------------------------------------------------------GLS----S-DSYKM---DY C_intestinalis_ENSCINP00000024485 HLPVASGFNSLSKQEYNHTSKLEPQYVSMENHRAFNGGYNQYNNYQSEI---------------------------------------------------KDTSTMGIL-DKYPM----- C_familiaris_ENSCAFP00000016420 ----------------------------------------------------------------------------------------------------QDQVP---T-YQYNM---NF G_gallus_ENSGALP00000014503 ----------------------------------------------------------------------------------------------------RIVTP---T-FQYNM---NY R_norvegicus_ENSRNOP00000009643 -------------------------------------------------------------------------------------------------MDSETINPQPLQEERYDM---SG T_guttata_ENSTGUP00000011206 ----------------------------------------------------------------------------------------------------RIVTP---T-FQYNM---DY O_latipes_ENSORLP00000010793 -------------------------------------------------------------------------------------------------CVIKQDAD---P-YRYSM---DY X_tropicalis_ENSXETP00000003217 ----------------------------------------------------------------------------------------------------TKFAH---L-HKYRT---DY D_rerio_ENSDARP00000063081 ----------------------------------------------------------------------------------------------------SSVQKV----SQYKI---TQ D_rerio_ENSDARP00000075650 ----------------------------------------------------------------------------------------------------SSVQEI----SPYRI---IK A_carolinensis_ENSACAP00000002670 -----------------------------------------------------------------------------------------------------VIEA---D-ESYRM---DH A_carolinensis_ENSACAP00000009923 --------------------------------------------------------------------------------------------------------P---T-FRYRM---DY G_aculeatus_ENSGACP00000023055 ----------------------------------------------------------------------------------------------------ALIRSSLDPAEEYKM---DN C_intestinalis_ENSCINP00000007986 YANQGTPPKRNRESSSYIEQMDDAPSPTDSLSNIRSTASVHSLFSRSDVRTQSNTAINHIN--TVQSPTSTKAATSYQINLHQGMDLFDGPTVSDLTVRKSTHQHLMQHTDCYQM-TMRG T_guttata_ENSTGUP00000004278 ----------------------------------------------------------------------------------------------------LNIRQSLDPAEEYKM---NH T_rubripes_ENSTRUP00000044662 DSYLNQIQLNTQLKALWLIKKFDSFLVSFSSNESWIGGSGNRPTNRCPLLTAA-SLLEQSC--SFNTLQVGCP----------------------D----VSVQG---V-ETYLM---TA A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------DDAHYNM---SH D_rerio_ENSDARP00000019984 ----------------------------------------------------------------------------------------------------RIVSP---T-FQYKM---SH M_domestica_ENSMODP00000032734 ----------------------------------------------------------------------------------------------------RPYEDDSSELDRYNM---DR B_taurus_ENSBTAP00000012869 ----------------------------------------------------------------------------------------------------RSYDCVDGELYRYDL---SG E_caballus_ENSECAP00000021726 KETESLHHGEEELFSRSDIKKFSRALPQPWEHTHAGLGSLPLGNSRVSKGWSS-ALASGIG--S-------------------------------I----SSSKE---T-PLYRM---DR B_taurus_ENSBTAP00000008706 ----------------------------------------------------------------------------------------------------RDRVP---T-YQYNM---NF M_musculus_ENSMUSP00000026062 ----------------------------------------------------------------------------------------------------RDRVP---T-YLYRM---DF D_rerio_ENSDARP00000024255 --------------------------------------------------------------------------------------------------------------EQYEM---KG A_carolinensis_ENSACAP00000013788 --------------------------------------------------------------------------------------------------------------DHYGM---KK M_musculus_ENSMUSP00000005488 -------------------------------------------------------------------------------------------------MESEMSDPQPLQEERYDM---SG R_norvegicus_ENSRNOP00000022693 ----------------------------------------------------------------------------------------------------RDRVP---T-YLYRM---DF A_gambiae_AGAP011949-PA -----------------------------------------------------------------------------------------------------MDSILEFELKSYDT---TH 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000364878 -EANMPGLNIRNKEFN-----YLHNRNGSELDLLGMRDLLENLGYSVVI-KENLTAQEMETALRQFAAHPE--HQSSDSTFLVFMSHSIL-------NGICGTKHWD--------QEPDV P_troglodytes_ENSPTRP00000047678 -GANMPGLNICNKEFN-----YLHNRNGSELDLLGMRDLLENLGYSVVI-KENLTAQEMETALRQFAAHPE--HQSSDSTFLVFMSHGIL-------NGICGTKHWD--------QEPDV P_pygmaeus_ENSPPYP00000004372 -GPNTPGLIICNKEFN-----YLHNRNGSELDLLGMQDLLENLGYSVVI-KENLTAQEMETALRQFAARPE--HQTSDSTFLVFMSHGIL-------NGICGTKHWD--------QEPDV M_mulatta_ENSMMUP00000021744 -GRTRLALIICNKEFH-----YLLNRNGSELDLLGMQDLLENLGYSVVI-EENLTAQEMETALRQFAARPE--HQSSDSTFLVFMSHGIL-------NGICGTEHWD--------QEPDV E_caballus_ENSECAP00000006810 -GRTRLALIICNKKFD-----YLSDRNGSEVDLVGMQDLLGNLGYSVVV-EENLTALEMETALRHFAARQE--HRSSDSTFLVFMSHGDL-------DGICGTKHNE--------EEPDI G_gorilla_ENSGGOP00000011776 -EANTSGLNICNKEFN-----YLHNRNGSELDLLGMRDLLENLGYSVVI-KENLTAQXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX-------XXXXXXXXXX--------XXXXX C_familiaris_ENSCAFP00000021904 -GRTRLALIICNSEFD-----YLSKRQGSEIDILGMQDLLENLGYSVVV-KENLSALEMKTELKNFAARQE--HKFSDSTFLVFMSHGTL-------DGICGTKHRN--------EEPDI M_musculus_ENSMUSP00000027009 -GRTRLALIICNKKFD-----YLFDRDNADTDILNMQELLENLGYSVVL-KENLTAQEMETELMQFAGRPE--HQSSDSTFLVFMSHGIL-------EGICGVKHRN--------KKPDV R_norvegicus_ENSRNOP00000029448 -GRTRLALIICNKKFD-----YLFDRDDAETDILNMKELLQNLGYSVVI-KENLTAQEMETELMKFAGRPE--HQSSDSTFLVFMSHGIL-------EGICGVKHRN--------KKPDV P_pygmaeus_ENSPPYP00000004373 -NRTRLALIICNTEFD-----HLPPRNGADFDITGMKELLEGLDYSVDV-EENLTARDMESALRAFAARPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDV P_troglodytes_ENSPTRP00000041705 -NRTRLALIICNTEFD-----HLPPRNGADFDITGMKELLEGLDYSVDV-EENLTARDMESALRAFATRPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDV B_taurus_ENSBTAP00000027820 -DRTRLALIICNTEFD-----HMPPRNGAALDILGMKQLLEGLGYTVEV-EEKLTARDMESVLWKFAAREE--HKSSDSTFLVFMSHGIL-------DGICGTMHSE--------EEPDV C_familiaris_ENSCAFP00000031565 -DRTRLALIICNIEFD-----HLSTRDGAELDIAGMESLLEGLGYSVVV-KRKLTAKGMESVLREFAARPE--HKSSDSTFLVLMSHGIL-------NGICGTAHSV--------ENPDV H_sapiens_ENSP00000347741 -NRTRLALIICNTEFD-----HLPPRNGADFDITGMKELLEGLDYSVDV-EENLTARDMESALRAFATRPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDV M_mulatta_ENSMMUP00000012893 -DRTRLALIICNTEFD-----HLPPRNGADFDITGMKELLEGLDYSVDV-EENLTAKDMESALRAFAARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHDE--------KNPDV E_caballus_ENSECAP00000010831 -DRTRRALIICNTEFD-----HLPFRTGADFDLSGMKRLLEDLGYSVDV-KEQLTATDMESVLREFAAHQD--HRSSDSTFLVFMSHGIL-------DGICGTTHSD--------EKPDV M_domestica_ENSMODP00000034020 -SRTRLALIICNKKFE-----NISERHGAEIDTIGMKTLLEDLDYNVYV-KENLTSLEMESALKEFASHPD--HQLSDSTFVVLMSHGVR-------HGICGIKHKN--------EDPDV M_domestica_ENSMODP00000034022 -FRTRLALIICNKEFD-----ELPRRNGAENDVTGMQNLLEGLGYRVHV-KENLTALEMESALKQFASYPE--HRTSDSTFLVLMSHGVP-------GGICGKDYTD--------KVPQI M_mulatta_ENSMMUP00000012894 -DRKRLALIICNTKFD-----HLPPRTGADFDILGMKGLLQGLGYNVVD-KTKLTAREMESELRAFARRPE--HKSSDSTFIVLMSHGIL-------EGICGTAHDE--------KNPDV P_troglodytes_ENSPTRP00000007279 -DRRRLALIICNTKFD-----HLPARNGAHFDILGMKRLLQGLGYTVID-EKNLTARDMESALRAFAARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHKK--------KKPDV H_sapiens_ENSP00000376849 -DRRRLALIICNTKFD-----HLPARNGAHYDIVGMKRLLQGLGYTVVD-EKNLTARDMESVLRAFAARPE--HKSSDSTFLVLMSHGIL-------EGICGTAHKK--------KKPDV E_caballus_ENSECAP00000021890 MTRTRLALIICNTEFD-----NLSRRAGAEVDIASMKVLLEGLGYSVEV-KENLTALDMTTELKAFAARPE--HRSSDSTFLVFMSHGIR-------EGICGKKFSE--------KVPDV H_sapiens_ENSP00000260309 -SRTRLALIICNEEFD-----SIPRRTGAEVDITGMTMLLQNLGYSVDV-KKNLTASDMTTELEAFAHRPE--HKTSDSTFLVFMSHGIR-------EGICGKKHSE--------QVPDI P_troglodytes_ENSPTRP00000059619 -SRTRLALIICNEEFD-----TIPRRTGAEVDITGMTMLLQNLGYSVDV-KKNLTASDMTTELKAFAHRPE--HKTSDSTFLVFMSHGIR-------EGICGKKYSE--------QVPDV P_pygmaeus_ENSPPYP00000004374 -DRTRLALIICNTEFD-----HLPARDGAQFDILGMKELLQGLDYTVVE-ENNLTASDMESVLRAFAARPE--HKSSDSTFLVLMSHGIL-------EGICGTVHDE--------KKPDV M_domestica_ENSMODP00000034033 -FRTRLALIICNKEFD-----ELPRRNGAENDVTGMQNLLEGLGYRVHV-KENLTALEMESALKQFASYPE--HRTSDSTFLVLMSHGVP-------GGICGKDYRE--------KDPQI G_gorilla_ENSGGOP00000015374 -DRRRLALIICNTKFD-----HLPARNGAHFDIXGMKRLLQGLGYTVVD-EKNLTARDMESXLRAFAXRPE--HKSSDSTFLVLMSHGIL-------EGICGTKHKK--------KKPDV P_pygmaeus_ENSPPYP00000004377 -SRTRLALIICNEEFD-----SIPRRTGAEVDITGMTMLLQNLGYSVDV-KKNLTASDMTTELKAFAHRPE--HKTSDSTFLVFMSHGIR-------EGICGKKHSE--------QVPDV B_taurus_ENSBTAP00000027821 -NRTRLALIICNTEFE-----NLTRRDGADVDTRNMKVLLEGLGYKVDV-KENLTASEMILELKAFAAHSE--HRTSDSTFLVFMSHGIR-------AGICGKKYSE--------EVPDI M_musculus_ENSMUSP00000027012 -GRTRKALIICNTEFK-----HLSLRYGANFDIIGMKGLLEDLGYDVVV-KEELTAEGMESEMKDFAALSE--HQTSDSTFLVLMSHGTL-------HGICGTMHSE--------KTPDV R_norvegicus_ENSRNOP00000009993 -TRTRLALIICNTDFQ-----HLSRRVGADVDLREMKLLLQDLGYTVKV-KENLTALEMTKELKEFAACPE--HKTSDSTFLVFMSHGLQ-------EGICGITYSN--------EVADI M_musculus_ENSMUSP00000027015 -TRTRLALIICNTEFQ-----HLSPRVGAQVDLREMKLLLEDLGYTVKV-KENLTALEMVKEVKEFAACPE--HKTSDSTFLVFMSHGIQ-------EGICGTTYSN--------EVSDI O_anatinus_ENSOANP00000016591 -GRQRQALIICNIKFE-----ELCERVGAELDIKGMKKLLEDLDYTVQV-ERNLSATEMESKLKMFAGRPE--HKFSDSTFLVFMSHGIL-------EGICGTKYKK--------QEPDV O_cuniculus_ENSOCUP00000000956 -GRTRLALIICNTEFD-----SLPRRTGADVDIRDMKMLLIGLGYSVDV-KENLNALDMATELKAFADRPE--HWTSDSTFLVFMSHGTR-------DGICGKNYSE--------QYSDI R_norvegicus_ENSRNOP00000058685 -GRTRKALIICNTEFK-----HLSLRYGANIDISGMKGLLEELGYDVVV-KEELTAEGMESEMKDFAALSE--HQTSDSTFLVLMSHGTL-------QGLCGTMHSE--------ATPDV M_mulatta_ENSMMUP00000012901 -GRTRLALIICNEEFD-----TLPRRTGAEVDITGMTMLLQNLGYSVDV-RKNLMASEMTTELEAFAHRPE--HKTSDSAFLVFMSHGIR-------EGICGKKYSE--------QVPDV G_gallus_ENSGALP00000001569 -RRTRRALLICNTKFK-----HLRQRDGAEVDVKEMTKLLEGLGYNVEC-HEDKTSQEMTTVMKKFADHKD--HLTSDSTFLVFMSHGMS-------TGICGTKSN---------GTTDI X_tropicalis_ENSXETP00000017024 -GRKRFALIICNEKFE-----TLTERQGAKVDLDGMTKLLNELGYQVLQ-ETNLAKEEMLKVLKEFAAREE--HVDSDSTFIVLMSHGDK-------PGVCGTDSKKIEHEKGQCQVTNL G_aculeatus_ENSGACP00000013201 -ISNRVALLITNIKFT----YEIPNRNGAEKDEENMEILMKGLGYEVVK-HRNLTAKAIDEALKEFAKHPK--LKKTDSVLVVLMSH-------------CGVDWKRE-------RKADE A_carolinensis_ENSACAP00000013361 -SRTRLALIICNITFA-----HLNKREGAEVDLRGMTLLLEDLGYRVEI-KINLTAKEMSTCLKDFAAREE--HKTSDSTFLVLMSHGVR-------DGLCGVQSRD--------KDSDV O_cuniculus_ENSOCUP00000006490 -DRTRLALIICNIEFQ-----HLPLRNGAQFDISGMKRLLEDLGYSVVV-KVKLTAKAMESVLQEFAARPE--HNSSDSTFVVLMSHGIL-------DGICGIMHSD--------KTQDV D_rerio_ENSDARP00000034228 -VRKRLALLINNVDFD----DKAMKRSGSEKDEENMEKLLKELDYQVVK-RPNLSAKEMDEAIRDFAQREE--HKYSDSAFVVIMSHGKR-------DAIMGVHYHRTN------NPSDS T_rubripes_ENSTRUP00000019853 -ISNRVALVITNITFF----HQCLNRKGAEKDEENMETLLKGLGYEVVK-YRNLTGRAIEEAIIDFSKRPK--LKDTDSVVVVIMSHGRM-------GVVAGVSTLSKT------FEDDL T_rubripes_ENSTRUP00000035020 -INNRVALVITNITFF----HQCLNRKGAEKDEENMETLLKGLGYEVVK-YRNLTGRAIEDAVIDFSKRPK--LKDTDSVVVVIMSHGRL-------GVVAGVSTQSPT------FEDDL O_latipes_ENSORLP00000007938 -YKSRVALMITNIKFS----NEKLNRAGAEKDEENMDRLLSKLGYEVVK-HKSLTGKAINEAFIEFTKHPK--LKETDSVIVVLMSHGKL-------GAVLGVEWKHDD------ENPDE T_rubripes_ENSTRUP00000013027 -INNRVALVITNITFF----------QGAEKDEENMETLLKGLGYEVVK-YRNLTGRAIEDAVIDFSKRPK--LKDTDSVVVVIMSHGRL-------GVVAGVSTQSPT------FEDDH D_rerio_ENSDARP00000059407 -QRKGLALLITNILFA----NKQDDRAGAERDEENMEWLLKNLNFMVIK-YRNLTGNEISRAVQDFSRRHE--HQDADSTFVVIMSHGDR---IQNKDAILGVNYNWLQ------NRNDV D_rerio_ENSDARP00000068268 -QRKGLALLITNIQFA----NTQHNRNGADRDEENAEWLLRSLGFAVIK-YRNLSGKDIRRAVENFSKRRE--HEDADSTFIVIMSHGTR---IDNKDAIVGVS-------------DDV D_rerio_ENSDARP00000008601 PQRKRLALLINNVDFK------DNVRTGADKDELSMERLLKGLGYSVVT-LRDLSAQGMSTAMRDFSQRKE--HADSDSCFVVLMSHGDE-------SGICGIFDSS--------SQDDV C_elegans_C48D1.2 -SPRGMCLIINNEHFE-----QMPTRNGTKADKDNLTNLFRCMGYTVIC-KDNLTGRGMLLTIRDFAKH----ESHGDSAILVILSHGEE-------NVIIGVD-------------DIP G_gallus_ENSGALP00000029853 -EPRGLALILSNIHFS--SEKDLEYRSGGDVDCASLELLFKHLGYQVTV-FHDQSAEEMESALERFSKLPD--HQDVDSCIVALLSHGVE-------GGVYGTD-------------GKL A_carolinensis_ENSACAP00000006831 -QPRGLALILSNIHFN--KETDLDFRSGGDVDNTALHMLFKHLGYQVVV-RQDRTAQEMKEELEIFSKHPA--HRNVDSCIVSLLSHGIE-------GGIYGID-------------GKL D_rerio_ENSDARP00000075318 -NPRGLCLIFNNENFK----DPDMKRHGSQMDTASLKDLFEWLGFSVEI-KQDQTVSAMKRTLKEYSED----RKHGDCFVCCVLSHGNE-------SGVLGSD-------------EKI X_tropicalis_ENSXETP00000015203 -CPRGRALIISNVAFE---TQDLDHRYGGEVDVTSLEKLFSSLGFQVEV-RRNLNAQNMMSQLGAFSALPA--HSALDSCVVAVLSHGLD-------GAVYGTD-------------GKL M_musculus_ENSMUSP00000031895 -QPRGLALVLSNVHFT--GEKDLEFRSGGDVDHTTLVTLFKLLGYNVHV-LHDQTAQEMQEKLQNFAQLPA--HRVTDSCVVALLSHGVE-------GGIYGVD-------------GKL R_norvegicus_ENSRNOP00000022672 -QPRGLALVMSNVHFT--GEKDLEFRSGGDVDHTTLVTLFKLLGYNVHV-LYDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKL E_caballus_ENSECAP00000003321 -RPRGLALVLSNVHFT--GEKDLEFRSGGDVDHSTLVTLFKLLGYNVHV-LLDQTAKEMQEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKL B_taurus_ENSBTAP00000024166 -RPRGLALVLSNVHFT--GEKDLEFRSGGDVDHSTLVTLFKLLGYKVHV-LLDQTAQEMQEKLQNFAQLPV--HRVTDSCIVALLSHGVE-------GGVYGVD-------------GKL O_anatinus_ENSOANP00000005545 -RPRGLALVLSNMRFN--GEKDLEFRSGGDVDHNALITLFKHLDYSVEF-LRDQTAQEMQEKLHNFAQSPR--HRFTDSCVVALLSHGVE-------GGIYGVD-------------GKL H_sapiens_ENSP00000312664 -RPRGLALVLSNVHFT--GEKELEFRSGGDVDHSTLVTLFKLLGYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKL P_troglodytes_ENSPTRP00000033921 -RPRGLALVLSNVHFT--GEKELEFRSGGDVDHSTLVTLFKLLGYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKL P_pygmaeus_ENSPPYP00000017020 -PEMGLCIIINNKNFH--KSTGMASRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVAKE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------G-P M_mulatta_ENSMMUP00000016588 -RPRGLALVLSNVHFT--GEKELEFRSGGDVDHSTLVTLFKLLGYDVHV-LRDQTAQEMQEKLQNFARLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKL O_anatinus_ENSOANP00000000517 -PNMGICLIINNKNFH--PDTRMGCRSGTDVDAASLRDTFKKLKYEVRC-KNDLKRREILELLTSVAHE-D--HSKRSSFVCVLLSHGEE-------GVIFGTD-------------G-S T_rubripes_ENSTRUP00000037606 -SPRGFALVISNVTFNPCAAPELDPRKGGEVDDEVLRKVFTELEYSVTV-QRDLTAQGIKTCIQNFSGRPE--HRSVDSCVVCLLSHGVE-------GAVYGID-------------GEL C_familiaris_ENSCAFP00000005409 -RPRGLALVLSNVHFT--GEKDLEFRSGGDVDHSTLVTLFKLLGYKVHV-LLDQTAQEMKEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GGIYGVD-------------GKL E_caballus_ENSECAP00000019797 -PEMGLCIIINNKNFH--KSTGMASRSGTDVDAANLRETFTNLKYEVRN-KNDLTGEEIVALMRSVSKE-D--HSKRSSFICVLLSHGEE-------GIIFGTN-------------G-P T_guttata_ENSTGUP00000013612 -EPRGLALILSNVRFS--SEKDLEYRAGGDVDCASLEMLFRHLGYRVTV-FCDQTAQDMQNALERFSKLQD--HRDVDSCIIALLSHGVE-------GGVYGSD-------------GKL P_troglodytes_ENSPTRP00000054330 -PEMGLCIIINNKNFH--KSTGMTSRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVSKE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------G-P H_sapiens_ENSP00000311032 -PEMGLCIIINNKNFH--KSTGMTSRSGTDVDAANLRETFRNLKYEVRN-KNDLTREEIVELMRDVSKE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------G-P P_pygmaeus_ENSPPYP00000020323 -RPRGLALVLSNVHFT--GEKELEFRSGGDVDHSTLVTLFKLLDYDVHV-LCDQTAQEMQEKLQNFAQLPA--HRVTDSCIVALLSHGVE-------GAIYGVD-------------GKL E_caballus_ENSECAP00000010379 -ARLALTLCVT------------KAREGSEADLDALERMFQQLGFESTT-KRDPTAQQFQEELEKFQQAMDAREDLVSCAFVVLMAHGVE-------GRLKGED-------------EQM M_mulatta_ENSMMUP00000015808 -PEMGLCIIINNKNFH--KSTGMASRSGTDVDAANLRETFINLKYEVRN-KNDLTREEIVELMRNVSKE-D--HSKRSSFVCVLLSHGEE-------GIIFGTN-------------G-P O_latipes_ENSORLP00000015114 -SPRGSVLVISNINFDPRAAPELDPRKGGEVDDEVLRKLFTELDYSVNF-HRDLTAQDMKMVIENFCRRPD--HQKVDSCVVCLLSHGVD-------GAIYGTD-------------GQQ G_aculeatus_ENSGACP00000013740 -SPRGFALVISNVTFDPCAAPDLDPRKGGEVDDEVLRKVFTELDYVVKV-HRDLTAQDMRTCIEEFSRRPD--HRTMASCVVCLLSHGVE-------GAIYGTD-------------GQL O_cuniculus_ENSOCUP00000001859 -RPRGLALVLSNVRFT--GEKDLEFRSGGDVDHSTLIALFKLLGYNVHV-LHDQTAQEMREKLQNFAQLPA--HRVMDSCIVALLSHGVE-------GGIYGVD-------------GKL M_domestica_ENSMODP00000001598 -RPRGLAMVLSNVHFN--GEKDLEFRSGGDVDHSSLVTLFKLLDYDVHV-LRDQTAQKMQENLQRFAQLSA--HQSTDSCMVALLSHGIE-------GGIYGVD-------------GKL T_nigroviridis_ENSTNIP00000009934 -PNLGHCIIINNKNFD--RRTGMNTRNGTDVDAANAMKVFSNLGYRVRV-HNDQTVAQISQLLTSAAKE-D--HSRCASFVCILLSHGDE-------GVLYGTD-------------G-P T_rubripes_ENSTRUP00000040691 -PNMGHCIIINNKNFD--RRTGMNTRNGTDVDAANAMKVFLSLGYKVKV-HNDQTVNQMKQLLVSAAEE-D--HSACASFVCVLLSHGDE-------GVFFGTD-------------G-S T_nigroviridis_ENSTNIP00000010874 -SPRGLALVISNVRFSPFAAPDLDPRQGGEVDDEVLRKVFTELDYLVTV-QRDLTAQGIKTCIENFSRRPE--HQSVDSCVVCLLSHGVE-------GAVYGVD-------------GKL T_guttata_ENSTGUP00000006879 -PEMGECIIINNKNFH--RYTGMSPRSGTDADAASVREVFMKLGYKIKI-NNDLSCEGIFNLLKNVSEE-D--HSKRSSFVCVLLSHGDE-------GLIYGTD-------------G-P D_rerio_ENSDARP00000083664 -CPRGLALVLSNVRFD-SANTDLDIRRGGEVDEETLRRLFTELDFKVSL-HRDLTAEAMRRCLEQFAQQQE--HAAYDCAVVCLLSHGVE-------GSVYGTD-------------GQL G_aculeatus_ENSGACP00000024809 -PCMGTCVIINIKNFD--LKTGLETRNGTDVDAAELEKTFSKLGYKVTL-VHDQTADQIVDLLRDVSTQ-D--HSNSGSFVCVLLSRGDE-------GGIYGTD-------------GSF M_domestica_ENSMODP00000004412 -DPCGYCLIINNVDFC--ASSGLSSRKGSNIDCEKMHNRFQALHFAVEV-ERNLSAKGMGAALQQLAER-D--HSALDCCVVVILSHGCQASHIQFPGAIHGTD-------------GAS G_gallus_ENSGALP00000017288 -PEIGVCVIINNKNFH--RDTGLSSRSGTDADAASVREVFMKLGYKVKL-NNDLSSRDIFKLLKNVSEE-D--HSKRSSFVCVLLSHGDE-------GLFYGTD-------------G-P E_caballus_ENSECAP00000015102 -DPCGHCLIINNVNFY--LASGLGRRVGSDIDCEKLRQRFSLLHFMVEV-KGDLTAKQMLRALGELARR-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP E_caballus_ENSECAP00000013731 -EKVGKCVIINNKNFD--RGTGMGVRNGTDKDAEALFKCFRNLGFDVVV-YNDCSCAKMKSLLKQASEE-D--HRNSACFACILLSHGEE-------NLIYGTD-------------G-M C_familiaris_ENSCAFP00000032189 -PEMGLCIIINNKNFH--KSTGMAPRSGTDVDAANLRETFTNLKYEVRN-KNDLTCEEILELMNSVSKE-D--HSKRSSFVCVLLSHGDE-------GIIFGTN-------------G-P C_familiaris_ENSCAFP00000023821 -ARLALTLCVT------------KAREGSEADLDALERMFQQLGFESTM-KRDPTAQQFQEELDKFQQAMDARDDFISCAFVVLMAHGLE-------GRLKGED-------------GEM R_norvegicus_ENSRNOP00000014096 -PEMGLCIIINNKNFH--KSTGMSARNGTDVDAANLRETFMALKYEVRN-KNDLTREEIMELMDSVSKE-D--HSKRSSFVCVILSHGDE-------GVIFGTN-------------G-P M_domestica_ENSMODP00000005556 -PEMGLCIIINNKNFH--PNTGMSFRSGTDVDAASLSDTFRSLKYEVRI-KNDLTCNEITELLNSVSKE-D--HSQRSSFICVILSHGEE-------GVIFGTD-------------R-S G_aculeatus_ENSGACP00000024812 -PCMGTCVIINNKTFD--PKTGLSPRNGTDVDAAELEKTFSRLGYKVTV-ANDQTADQMVDLLADVSKQ-D--HRKSASFVCALLSHGDE-------DGIYGTD-------------G-- O_latipes_ENSORLP00000010095 -PTIGLCIIINNKNFD--RGTGMNQRNGTDIDAASAMKVFSKLGYRVKI-YNDQTVKQIKQLLTDVSRM-D--HSDSASFVCILLSHGDE-------GVFFGTD-------------G-S P_pygmaeus_ENSPPYP00000002138 -DPCGHCLIINNVNFC--RESGLRTRTGSNIDSEKLRRRFSSLHFMVEV-KGDLTAKEMVLALLELAQQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP G_aculeatus_ENSGACP00000024816 ----------------------MSPRNGTDVDAADAFRTFSKLGYKVTV-ANDQTVDQMIQLLVKVSKQ-D--HSNSASFVCVLLSHGDE-------GVIYGTD-------------G-F O_cuniculus_ENSOCUP00000002346 -ARLALTLCVT------------KAREGSEADLDALERMFQQLGFESTV-KRDPTAQQFQEELEKFQQTIDAWKDPVSCAFVVLMAHGDE-------GVLKGED-------------EEM G_aculeatus_ENSGACP00000022402 -PSIGQCIIINNKNFD--RGTGMNQRNGTDVDAANAMKVFGNLGYKVKV-YNDQSVAQIQHVLTSVSKQ-D--HSCSASFVCVLLSHGDG-------DLFFGTD-------------G-P T_guttata_ENSTGUP00000017449 -DPCGHCLILNNVNFC--RDSGLSTREGSDIDCEKLERRFKALCFTVLT-RRDLKAQEMVLELLKLSRQ-D--HSALDCCIVVILSHGCQTSHIQFPGGVYGTD-------------GKP R_norvegicus_ENSRNOP00000017972 -DPCGHCLIINNVNFC--PSSGLSTRIGSHVDCEKLQHRFCWLRFMVEV-KNDLTAKKMVTALMEMAHR-D--HRALDCFVVVILSHGCQASHLQFPGAVYGTD-------------GCS B_taurus_ENSBTAP00000028116 -ARLALTLCVT------------KAREGSEADLDALERMFQQLGFESTM-KRDPTAQQFQEELEKFQQAIDAREDFVSCAFVVLMAHGLE-------GRLKGKD-------------EKM G_gallus_ENSGALP00000002083 -DPCGHCLIFNNVSFS--RDSDLSTRAGSDIDCEKLEKRFRSLCFHVRT-LRNLKAQEIDVELRKLARL-D--HSALDCCLVVILSHGCQTSHIQFPGGIYGTD-------------GKI M_musculus_ENSMUSP00000030747 -DPCGHCLIINNVNFC--PSSGLGTRTGSNLDRDKLEHRFRWLRFMVEV-KNDLTAKKMVTALMEMAHR-N--HRALDCFVVVILSHGCQASHLQFPGAVYGTD-------------GCS M_musculus_ENSMUSP00000091238 -PEMGICIIINNKNFH--KSTGMSSRSGTDVDAANLRETFMGLKYQVRN-KNDLTREDILELMDSVSKE-D--HSKRSSFVCVILSHGDE-------GVIYGTN-------------G-P X_tropicalis_ENSXETP00000035938 -GKVGRCIIINNKNFD--DITGMSPRNGTDIDARDLLRCFKGLGFDVTV-FNNKSCTEMETLLRSVAEQ-D--HKDSACFACIFLSHGEE-------GLIYGTD-------------G-A O_anatinus_ENSOANP00000015596 -EPCGHCLIINNVDFS--LGSGLSTRTGSDVDCEKMKRRFRLLHFEVAV-ERNLTAEEMVKALNKLAKK-D--HSALDCCVVVILSHGYQASHIQFPGGIHGTD-------------GES B_taurus_ENSBTAP00000003205 -DPCGHCLIINNVNFC--RESGLRARTGSNIDCERMRQRFHLLQFVVEV-KCDLTAKQMVQALMQLARQ-D--HSALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP C_intestinalis_ENSCINP00000002956 -KSRGYALIVCIGRFN--AGVRLPDRQGTDADKKNLLAIFEQINYKTIL-VENCNKFEMERRVKQFAQMEE--HRKCDSCAVAILSHGSK-------TDIYASD-------------GRS T_nigroviridis_ENSTNIP00000022078 -QRVGKCIIINNKNFD--EKTGMNVRNGTDRDAGELYKCFKSLGFDVFI-YNDQTCEKMEHLLREASEE-D--HSDSSCFACILLSHGEE-------GMIYGTD-------------G-A G_aculeatus_ENSGACP00000005791 -AKRGICLIVNNFDFT--KFKNYQNREGTMKDEERLHKVFAWLGFEVEV-KHDCEGEQMLTALRELASR-N--HGQADCLVCCVLSHGDE-------GCVYGVD-------------GHT B_taurus_ENSBTAP00000021099 -PEMGLCIIINNKNFH--ENTGMCRRSPTDDSVAQXRETFMNLKYEVRI-KNDLTCKEMLELMSNVSKE-D--HSKRSSFICVLLSHGEE-------GIIFGTN-------------G-P P_troglodytes_ENSPTRP00000056642 -EPCGHCLIINNVNFC--RESGLRTRTGSNIDCEKLRRRFSSLHFMVEV-KGDLTAKEMVLALLELARQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP D_rerio_ENSDARP00000006831 -PNIGHCIIINNKNFD--RRTGMNPRNGTDVDAGNVMNVFRKLGYIVKV-YNDQTVAQIMQVLTTVAHD-D--HSRCASLVCVLLSHGDE-------GVFFGTD-------------T-S H_sapiens_ENSP00000221740 -ARLALILCVT------------KAREGSEEDLDALEHMFRQLRFESTM-KRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGRE-------GFLKGED-------------GEM D_rerio_ENSDARP00000071815 -PNLGQCLIINNKNFH--KRTGMGVRNGTDEDAKKVFETFSQLGFKVGH-YNDLTVSQMMALLNKASQE-D--HSKSAMFACVLLSHGDD-------GLIYGTD-------------N-S T_rubripes_ENSTRUP00000031759 -QRVGKCIIINNKNFD--EKTGMNVRNGTDRDAGELFKCFKTLGFDVFI-YNDQTCEKMERLLREASEE-D--HSDSSCFACILLSHGEE-------GMIYGTD-------------G-A M_mulatta_ENSMMUP00000040583 -EPCGHCLIINNVNFC--RESGLSTRTGSSIDCEKLQRRFSLLHFMVEV-KHDLTAKEMVLALLELARR-D--HSALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP H_sapiens_ENSP00000365051 -EPCGHCLIINNVNFC--RESGLRTRTGSNIDCEKLRRRFSSLHFMVEV-KGDLTAKKMVLALLELAQQ-D--HGALDCCVVVILSHGCQASHLQFPGAVYGTD-------------GCP C_familiaris_ENSCAFP00000023986 -DPCGYCLIINNVNFC--PESRLTARGGSNIDCEKLQRRFCLLRFTVEV-KWDLTAKQMVQALVELARR-D--HSALDCCVVVVLSHGCEASHRQFPGAVYGTD-------------GCP M_mulatta_ENSMMUP00000024183 -ARLALTLCVT------------KAREGFEEDLDALEYMFRQLRFESTM-KRDPTAQQFQEELEKFQQAIDSREDPISCAFVVLMAHGRE-------GFLKGED-------------GEM C_familiaris_ENSCAFP00000007585 -SRKAFLMCVE------------KSRPGAHRDIELMKEWLGQCQFEHTA-CIDPNKMELLRKITLFRDGLNEIKGDVGCCLITLMSHGEN-------GFIKMED-------------GEK G_aculeatus_ENSGACP00000008661 -QRVGKCIIINNKNFD--EKTGMNVRNGTDRDAGELFKCFKSLGFDVFI-YNDQTCGKMESLLREASEE-D--HSDSSCFACILLSHGEE-------GMIYGTD-------------A-A M_domestica_ENSMODP00000018104 -ARLALTLCIT------------KNRAGSETDVQALEKMFKALNFKNTV-RRNIPAKGFWEELEKFRDDMDQMKDPVSCCFVVLMAHGEE-------GILQGVD-------------GNT M_domestica_ENSMODP00000005560 -PEMGLCVIINNTHFH--NDTELSPRTGSDKDAANLIDIFRSLKYEVRN-KNNLTRDKMIELLRQVSEE-D--HSQRSSFVCVILSHGEE-------GVIFGTD-------------D-S C_intestinalis_ENSCINP00000024485 -ERRGYCLIINNENFE--R----QDRTGSGNDTERLENLFKEFGFILDV-RKDLDQREMEKVIQEYTKK-D--HSDKDCFVCVVMSHGLS-------GCVYGVD-------------GLS C_familiaris_ENSCAFP00000016420 -EKVGKCIIINNKNFD--KTTGMGVRNGTDKDAEALFKCFRNLGFDVVI-YNDCSCAKMQDLLKKASEE-D--HRNSACFACILLSHGEE-------NLIYGTD-------------G-M G_gallus_ENSGALP00000014503 -KKVGKCIIINNKNFE--DKTGMGTRNGTDKDAGDLSKSFRSLGFDVYT-YNDRSCEDMQTLLKQAAEE-N--HSDAACFACILLSHGEE-------GLIYGTD-------------G-P R_norvegicus_ENSRNOP00000009643 -ARLALTLCVT------------KAREGSEVDMDALERMFQYLKFESTM-KRDPTAQQFLDDMDEFQQTIENWKEPVSCAFVVLMAHGEE-------GFLKGED-------------GNM T_guttata_ENSTGUP00000011206 -KKVGKCIIINNKNFE--DKTGMGTRNGTDKDAGDLAKSFKNLGFEVDI-HHDRSRDDMEKLLKKAAEE-N--HSDAACFACILLSHGEE-------GLIYGTD-------------G-P O_latipes_ENSORLP00000010793 -PKMGICLIINNKNFH--KDSGMGPRNGTDNDAAAAWKSFMKLGYEIQM-YNDQTVDQMKKLFRQMSNQ-D--HSKFASFACVILSHGEE-------GVIYGTD-------------G-P X_tropicalis_ENSXETP00000003217 -PEMGICLIINNKNFQ--SSTNMGVRNGTDVDARKLHETFTGLGYKVKV-CNDQKSNDIFTLLKKMSEE-D--HSKRSSFVCAILSHGED-------GLVYGVD-------------G-P D_rerio_ENSDARP00000063081 -NPRGICVIINNVDF-----TSMGERRGSDEDQNYLAKVFRWLGFEVVA-HRNKTAAEMKNILQALGRTVD-----GDCFVCCVLSHGVE-------EGVCGTD-------------GSL D_rerio_ENSDARP00000075650 -NPRGICVIINNEIFS----SGMMSRRGSDKDREYLAKVFHWLGFEVVE-HNNKDTAEIRNILKDLGRTVD-----GDCFVCCILSHGRR-------EGVCGTD-------------GNY A_carolinensis_ENSACAP00000002670 -PEMGLCILVNNKNFH--PATGMSYRSGTDRDAAHVVDTFRTLGYMVKP-YNDLTCKQIVDVLHNVSKD-D--HHKRNSFVCVLLSHGED-------GLIYGTD-------------G-H A_carolinensis_ENSACAP00000009923 -KKLGKCVIINNKNFA--KDTGMRIRNGTDKDAGDLQKCFRGIGFDVSI-YNDLTCDNMEKILGEAALE-N--HDDAACFACILLSHGEE-------GLIYGTD-------------G-C G_aculeatus_ENSGACP00000023055 -KRRGLALIFNQERFF--WRLGLNDRHGTNADRYNLERRLSNLNFDVRA-YDNLKQEEVLNKINEAAEE-N--HSDSDCFLLVFLSHGEN-------DQVYTYD-------------G-K C_intestinalis_ENSCINP00000007986 -RPKGAALIISVEKFH--PESDLLNREGSEKDRVRLELVLQQIGFQCYV-LINGTAEQIVSTLQTFAELEE--HYDNSCSLVAAMSHGDA-------GCFYGSD-------------GVS T_guttata_ENSTGUP00000004278 -QRRGLALIFNHERFY--WHLRLQDRRGTWVDRNNLKSILTELGFEVRL-FDDLKKEDVQQRIYEASTA-D--HSNADCFVCVFLSHGED-------GHIFAYD-------------D-K T_rubripes_ENSTRUP00000044662 -AKRGRCLIINNCNF---RVSRLKKREGTMVDEASLDKVLKWLGFEVEI-QRDCTSKKMSSLIQELAKT-S--QRDWDCVMCCVLSHGLE-------GGVYGVD-------------GGT A_gambiae_AGAP004920-PA -NRRGVAAVFNHRKFL-----HASERKGTDADCDNIRQVLIYLQFEVRV-YDDLTRKEIKQVLDDLAEE-D--HKNSDCLLVVIMTHGDD-------DVLHAKD-------------G-T D_rerio_ENSDARP00000019984 -QRVGKCIIINNKNFD--EKTGMNVRNGTDRDAGELFKCFKSLGFDVAV-YNDQTCRNMERLLKAVSEE-D--HSDSSCFACILLSHGEE-------GMIYGTD-------------G-A M_domestica_ENSMODP00000032734 -TRKAFVMCVK------------TGRPGAKQDISRIKNWLEKCKFEYTY-CDDPDEEELFEKLTQFRDGINGIKEEVSCCLVTLMAHGGK-------GHIKTKS-------------NER B_taurus_ENSBTAP00000012869 -RRKAFLMCVK------------KNRLGAHQDVQLMKDWLKECKFEPTL-CIDPDKMDLLGKITSFRDELNEIKDDIGCCLVTLMSHGEE-------GFIKMKD-------------GEK E_caballus_ENSECAP00000021726 -THRGHCVVVNNHTF-----TSLADRPGTDKDAECLKSVFQWLGFSVHR-YDNVTKEGLEKVLQEYRNHPG--HASGDCFVFCVLTHGKF-------GAVYSSD-------------GIL B_taurus_ENSBTAP00000008706 -EKVGKCIIINNKNFD--RITGMGVRNGTDKDAEALFKCFRSLGFDVSV-YNDCSCAKMQDLLKKASEE-D--HRNSACFACILLSHGEE-------NLIYGTD-------------G-K M_musculus_ENSMUSP00000026062 -QKMGKCIIINNKNFD--KATGMDVRNGTDKDAGALFKCFQNLGFEVTV-HNDCSCAKMQDLLRKASEE-D--HSNSACFACVLLSHGEE-------DLIYGKD-------------G-V D_rerio_ENSDARP00000024255 -ERRGVCLIINNYDFS---ACGWLNREGTDIDHDSLRDVFEWLGFEILT-RRDCTGDQILQALMDLSTQ-D--HTQADCVVCCILSHGRL-------NDIIGVD-------------GKA A_carolinensis_ENSACAP00000013788 -KRVAFMMCVT------------EGRAGAEEDIKKMKKWFRTFKFTLLGDCRNPGQETLMQQLRQFRDIINLSNEEISCCLITLMSHGKA------NGYILDKD-------------NRE M_musculus_ENSMUSP00000005488 -ARLALTLCVT------------KAREGSEVDMEALERMFRYLKFESTM-KRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEE-------GLLKGED-------------EKM R_norvegicus_ENSRNOP00000022693 -EKMGKCIIINNKNFD--KATGMDVRNGTDKDAEALFKCFRSLGFEVTV-YNDCSCAKMQDLLRRASEE-D--HSNSACFACVLLSHGEE-------NLIYGKD-------------G-V A_gambiae_AGAP011949-PA -PNRGIAVVINDS----------ERREGSEKDVQDVVATLEGLKFNVRT-FQDNTKKEIKKALYKVARE-D--HNENDCLVIVAMAHGKK-------DHITLKK--------------EK 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000364878 LHDDTIFEIFNNRNCQSLKDKPKVIIMQACRG-----NGAGIVWFTTDSGK-A-----GADTHGRLLQGNI---------CN--------------DAVTKAHVEKDFIA---FKSSTPH P_troglodytes_ENSPTRP00000047678 LHDDTIFEIFNNRNCQSLKDKPKVVIMQACRG-----NGAGIVWFTTDSGK-A-----SADTHGRLLQGNI---------CN--------------DAVTKAHVEKDFIA---FKSSTPH P_pygmaeus_ENSPPYP00000004372 LHDDTIFEIFNNRNCRSLKDKPKVIIMQACRG-----NGAGIVWFTIDSGK-A-----SADTHGRLLQGNI---------CN--------------DAVTKAHVEKDFIA---FKSSTPH M_mulatta_ENSMMUP00000021744 LHDDTIFEIFNNRNCRSLRDKPKVIIMQACRG-----SGAGIVWFTTDSGK-A-----SAETHGQLLQSSI---------CN--------------DAVTKAHVEKDFIA---FKSSTPH E_caballus_ENSECAP00000006810 LHDDTIFQIFNNRNCRSLRDKPKIIIIQACRG-----RGDGSVW-VTDTGV-A-----SAYSSDQPFQGYI---------WN--------------DAVTKTHVEKDFIA---FKSSTPH G_gorilla_ENSGGOP00000011776 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XGAGIVWFTTDSGK-A-----SADTHGRLLQGNI---------CN--------------DAVTKAHVEKDFIA---FKSSTPX C_familiaris_ENSCAFP00000021904 LHDDTIFQIFNNRNCRSLKDKPKVIIMQACRG-----RGDGAVW-VTDVGE-A-----SAWTCDQPLQCYI---------FN--------------DAIEKTHVEKDFIA---FKSSTPH M_musculus_ENSMUSP00000027009 LHDDTIFKIFNNSNCRSLRNKPKILIMQACRG-----RYNGTIW-VSTNKGIA-----TADTDEERVLSCK---------WN--------------NSITKAHVETDFIA---FKSSTPH R_norvegicus_ENSRNOP00000029448 LHDDTIFTIFNNSNCPSLRNKPKILIMQACRG-----RHTGTIW-VSTSKGIA-----TADTDEECVLSHR---------WN--------------NSITKAHVETDFIA---FKSSTPH P_pygmaeus_ENSPPYP00000004373 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-----ANRGELW-VRDSPA-S-----LEVASSQSPE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH P_troglodytes_ENSPTRP00000041705 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-----ANHGELW-VRDSPA-S-----LEVASSQSSE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH B_taurus_ENSBTAP00000027820 LPYDTIFRTFNNRNCLSLKDKPKVIIVQACRG-----ANRGELW-VSDSPP-A-----LADSFSQSSE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH C_familiaris_ENSCAFP00000031565 LAYDTIFQIFNNRHCLNLKDKPKVIIIQACRG-----ENPGELW-VSDSPK-A-----STDSWTHQPL-ML---------KS--------------DAIHKVHVEKDFIA---FCSSTPH H_sapiens_ENSP00000347741 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-----ANRGELW-VRDSPA-S-----LEVASSQSSE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH M_mulatta_ENSMMUP00000012893 LLYDTVFQIFNNRNCLSLKDKPKVIIVQACRG-----ANRGELW-VRDSPA-S-----LEVASSQSPE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH E_caballus_ENSECAP00000010831 LPYDTIFRLFNNRNCPSLKDKPKVIIVQACRG-----ANRGELW-IRDCLA-A-----LA------PE-NL---------EE--------------DAVYKTHVEKDFIA---FCSSTPH M_domestica_ENSMODP00000034020 FLYETMYEILNTRNCPNLKDKPKIIIVQACRG-----DNYGEVW-VNDSSA-S-----CAD-SPKELQ-VF---------DH--------------DAVSRAHSEKDFIA---FHSSTPN M_domestica_ENSMODP00000034022 LDVNKIFQIFNTSNCPTLKDKPKIIILQACRG-----ENDGVVW-VNDSSK-S-----SQQRCSQNLP-IF---------ED--------------DAVRRAHVEKDFIA---FCSSTPD M_mulatta_ENSMMUP00000012894 LLYDTVFQIFNNRNCLNLKDKPKVIIVQACRG-----KGRGEHW-VRDSPA-S-----LAVISSQSPE-NL---------EE--------------DSVCRVHVEKDFIA---FCSSTPH P_troglodytes_ENSPTRP00000007279 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-----EKLGELW-VRDSPA-S-----LAVISSQSSE-NL---------EA--------------DSVCKIHEEKDFIA---FCSSTPH H_sapiens_ENSP00000376849 LLYDTIFQIFNNRNCLSLKDKPKVIIVQACRG-----EKHGELW-VRDSPA-S-----LALISSQSSE-NL---------EA--------------DSVCKIHEEKDFIA---FCSSTPH E_caballus_ENSECAP00000021890 LEVNTIFQIFNTRNCPNLRDKPKVIIIQACRG-----ENQGVVW-LKDSTG-T-----SGSSSSLAPD-DF---------ED--------------DAIKKAHVEKDFIA---FCSSTPD H_sapiens_ENSP00000260309 LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG-----DSPGVVW-FKDSVG-V-----SGNLSLPTTE-EF---------ED--------------DAIKKAHIEKDFIA---FCSSTPD P_troglodytes_ENSPTRP00000059619 LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRG-----DSPGVVW-FKDSVG-V-----SGNLSLPTTE-EF---------ED--------------DAIKKAHIEKDFIA---FCSSTPD P_pygmaeus_ENSPPYP00000004374 LLYDTIFQIFNSHNCVSLKDKPKVIIVQACRG-----EKHGELW-VRDSPA-S-----LAVISSQSSE-NL---------EA--------------DSVRKIHKEKDFIA---FCSSTPH M_domestica_ENSMODP00000034033 LDVNKIFQIFNTSNCPNLKDKPKILILQACRG-----ENDGAVL-VNDSSD-S-----SEHRCIQNLP-IF---------ED--------------DAVRRAHVEKDFIA---FCSSTPD G_gorilla_ENSGGOP00000015374 LLYDTIFXIFNSRNCXSLKDKPKVIIVQACRG-----EKHGELW-VRDSPA-S-----LAVISSQSSE-NL---------EX--------------DXVCKIHEEKDFIA---FXSSTPH P_pygmaeus_ENSPPYP00000004377 LQLNEIFKMLNTKNCPSLKDKPKVIIIQACRG-----DSHGVVW-LKDSVG-V-----SRNISLPTTE-EF---------ED--------------DAIKKAHIEKDFIA---FCSSTPD B_taurus_ENSBTAP00000027821 LKVDDIFHILNTGNCPALKDKPKVIIIQACRG-----EKQGMVW-VNDSVA-A-----SGNCSLVAPE-DF---------ES--------------DAIKKAHIEKDFIA---FCSSTPD M_musculus_ENSMUSP00000027012 LQYDTIYQIFNNCHCPGLRDKPKVIIVQACRG-----GNSGEMW-IRESSK-P-----QLCRGVDLPR-NM---------EA--------------DAVKLSHVEKDFIA---FYSTTPH R_norvegicus_ENSRNOP00000009993 LKVDTIFQMMNTLKCPSLKDKPKVIIIQACRG-----EKQGVVL-LKDSVG-N-----S-EEGFLTDA-IF---------ED--------------DGIKKAHIEKDFIA---FCSSTPD M_musculus_ENSMUSP00000027015 LKVDTIFQMMNTLKCPSLKDKPKVIIIQACRG-----EKQGVVL-LKDSVR-D-----S-EEDFLTDA-IF---------ED--------------DGIKKAHIEKDFIA---FCSSTPD O_anatinus_ENSOANP00000016591 LSYSTIFRVFNNINCPGLKDKPKIIIVQACRG-----ENEGMAW-VSDSLG-P-----SAT-SSQEPE-DL---------EN--------------DAIHRTHVEKDLIA---FCSSTPD O_cuniculus_ENSOCUP00000000956 LNVNTIFEMLNTKNCQSLKDKPKVIIIQACRG-----ENQGIVW-LKDSIG-D-----SGNTSLLNPD-DF---------EY--------------DASRIAHIEKDFIA---FCSSTPD R_norvegicus_ENSRNOP00000058685 LLYDTIYQIFNNCHCPGLRDKPKVIIVQACRG-----GNPGEVW-IRESSG-A-----HSYRAVDLPR-NM---------EA--------------DAVRMSHVEKDFIA---LYSTTPH M_mulatta_ENSMMUP00000012901 LQLNVIFEMLNTRNCPSLKDKPKVIIIQACRG---------------------------------------------------------------------------------------D G_gallus_ENSGALP00000001569 LSFNTIYENFNNKHCRALMGKPKVVIIQCCRG-----DNIGSVQ-IRDSID-P---EMPTSTSDGWRCVEL---------QG--------------SKTREAHLESDFAT---LYSSTPD X_tropicalis_ENSXETP00000017024 LQTDEIFSIFNNIHCPKLRDKPKVIIIQACRG-----EERGQKL-VCDAVA-L------------PPEEQL---------ED--------------DALHRVQRETDFIC---FCSSTPD G_aculeatus_ENSGACP00000013201 FPIDNIYKHLGPENCPALLDKPKIIIIQACRG-----GDEGAVV-VRDGDG-P------ALACDDAGEEDI---------ED--------------DNLRLVNKEKDFSS---LLSCTPD A_carolinensis_ENSACAP00000013361 LPIDDVFSIFNNNNCRALYEKPKVVIIQACRG-----TNKGVTY-VSDSVV-P---VVPSADSASSSA-NY---------EE--------------DAVRMVHLESDFIC---LYSTT-- O_cuniculus_ENSOCUP00000006490 LPYDTVFRTLNNRNCISLRDKPKVIIVQACRG-----XXXXXXX-XXXXXX-X-----XXXXXXXXXX-XX---------XX--------------XXXXXXXXXXXXXX---XXXXXXX D_rerio_ENSDARP00000034228 FPVDNVYRRLNSENCPALRDKPKVILIQACRG-----GEHGRVW-ASDGEP-DE-PI-----------------------EI--------------EDDDFVHKEKDFIS---LMSCTPD T_rubripes_ENSTRUP00000019853 FSLDKIYRLLGPEHCPALLNKPKIIIIQACRG-----DEGGEII-CNDQHP-P-------ENPPVSDDANI---------QE--------------DAIRIEHTEKDSIC---FFSCTPN T_rubripes_ENSTRUP00000035020 FSLDKIYRHLGPEHCPALLNKPKIIIIQACRG-----DERGEII-FNDQHP-P-------ENPPVSDDANI---------QE--------------DAIRIEHKEKDFIW---LLSCTPD O_latipes_ENSORLP00000007938 FPVNSIYEHLGPEKCPALLDKPKIIIIQACRG-----DQTGSVC-ISDSGN-Q-----AEEFLHPAAAGDL---------LE--------------DNLRFVHKEKDFIS---LLSCTPD T_rubripes_ENSTRUP00000013027 FSLDKMYRLLGPEHCPALLNKPKIIIIQACRG-----DERGEII-FNDQHP-P-------ENPPVSDDANI---------QE--------------DAIRIEHKEKDFVS---LLSCTPD D_rerio_ENSDARP00000059407 YFVEDTFSHLNSVNCPALIDKPKVILIQACRG-----GQLGGVP-VKDCVP---------------------------------------------ESDSWVHKEKDFVC---FMSTMPD D_rerio_ENSDARP00000068268 YFIEETFSHLNSVNCPALIDKPKVILIQACRG-----GQSSGVL-AQDSVF---------------------------------------------ASDSWVHMEKDFVC---FMSTMPN D_rerio_ENSDARP00000008601 FPPDEIFKYLNTPNCAGLRDKPKIILIQSCRG-----GKPGNVD-VPDSVP-I-------------------------------------------RGTRREHKEKDFCC---FRSSTPV C_elegans_C48D1.2 ISTHEIYDLLNAANAPRLANKPKIVFVQACRG-----ERRDNGF-PVLDSV-DGVPAFLRRGWDNRDGPLFNFLGCVRPQVQ--------------QVWRKKPSQADILI---AYATTAQ G_gallus_ENSGALP00000029853 LQLQEAFRLFDNANCPNLQNKPKMFFIQACRG-----DETDRGV-DQRDGK-E---WSDSPGCEESDANK----------EE--------------NLKLRLPTRSDMIC---GYACLKG A_carolinensis_ENSACAP00000006831 LQLQEIFRLFDNANCPNLQNKPKMFFVQACRG-----DETDHGV-DQIDGN-D---RASSPGCEETDANK----------KE--------------NPKLRLPTCSDMIC---GYACLKG D_rerio_ENSDARP00000075318 CPVDDITSPFNGANCSSLAGKPKVFFIQACRG-----HEIQSKV-MVADGS-GG-SRTQKPG----------------------------------RVSVSIPKDSDFLI---ARSTVEG X_tropicalis_ENSXETP00000015203 VQLQDVFTAMDNAHCPQLQNKPKMFFIQACRG-----EEADRGV-DQRDGR-E---QSASPGCEQSDAGR----------ED---------------IKVRLPTQSDMIC---AYACLKG M_musculus_ENSMUSP00000031895 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HTQSPGCEESDAGK----------EE--------------LMKMRLPTRSDMIC---GYACLKG R_norvegicus_ENSRNOP00000022672 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAQSPGCEESDAGK----------EE--------------LMKMRLPTRSDMIC---GYACLKG E_caballus_ENSECAP00000003321 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAKSPECEESDAGK----------EE--------------LLKMRLPTRSDMIC---GYACLKG B_taurus_ENSBTAP00000024166 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DLQDGK-N---HDRSPKCEESDASR----------EE--------------LLKMRLPTRSDMIC---GYACLRG O_anatinus_ENSOANP00000005545 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQRDGK-E---RAASPGCEESDAGK----------EE--------------MLKVRLPTRSDMIC---GYACLKG H_sapiens_ENSP00000312664 LQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAGSPGCEESDAGK----------EK--------------LPKMRLPTRSDMIC---GYACLKG P_troglodytes_ENSPTRP00000033921 LQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAGSPGCEESDAGK----------EK--------------LPKMRLPTRSDMIC---GYACLKG P_pygmaeus_ENSPPYP00000017020 VDLRKITNFFRGDRCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGV-D---------------------------DD--------------MACHKIPVEADFLY---AYSTAPG M_mulatta_ENSMMUP00000016588 LQLQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAGSPGCEESDAGK----------EK--------------LPKMRLPTRSDMIC---GYACLKG O_anatinus_ENSOANP00000000517 LELKSLASLFRGDNCRSLVGKPKLFIVQACRG-----TELDSGV-EADSSS-A---------------------------DD--------------GSEQKIPVEADFLY---AYSTAPG T_rubripes_ENSTRUP00000037606 LQLDWVFEAFDNAHCPLLQNKPKMFFIQACRG-----DEMDCGV-EQIDGP-S---RTSSPSCEQRDAGR----------EG--------------RPRIKLPQRSDMIC---GFASLKG C_familiaris_ENSCAFP00000005409 LQLQEVFRLFDNASCPNLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HTGSSECEESDASK----------EE--------------LLKTRLPTRSDMIC---GYACLRG E_caballus_ENSECAP00000019797 IDLKKLTCFFKGDCCRSLAGKPKLFIIQACRG-----TELDSGI-ETDSGI-E---------------------------DD--------------MACQKIPVEADFLY---AYSTAPG T_guttata_ENSTGUP00000013612 LELQETFRLFDNANCPNLQNKPKMFFIQACRG-----DELDRGV-DQRDGK-G---RSDSPGCEESDANK----------EE--------------SLKLRLPTCSDMIC---GYACLKG P_troglodytes_ENSPTRP00000054330 VDLKKITNFFRGDRCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGV-D---------------------------DD--------------MACHKIPVEADFLY---AYSTAPG H_sapiens_ENSP00000311032 VDLKKITNFFRGDRCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGV-D---------------------------DD--------------MACHKIPVEADFLY---AYSTAPG P_pygmaeus_ENSPPYP00000020323 LQLQEVFQLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---HAGSPGCEESDAGK----------EK--------------LPKMRLPTRSDMIC---GYACLKG E_caballus_ENSECAP00000010379 VELESLFEVLNNKNCQALKARPKVYIVQACRG-----EQRDPGE-TV--------------GSDDIMMI-----------AK--------------DSPETIPTYTDTLH---IYSTVEG M_mulatta_ENSMMUP00000015808 LDLKKITSFFRGDCCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGV-E---------------------------DD--------------MACHKIPVEADFLY---AYSTAPG O_latipes_ENSORLP00000015114 LALDWVFEAFDNAHCPLLQNKPKMFFIQACRG-----DEMDCGV-EQIDGP-A---RTFSPTCEQRDAGR----------EEQGD-ADGRQRASTGRQRIKLPQRSDMIC---GFASLKG G_aculeatus_ENSGACP00000013740 LKLDWVFESFDNAHCPLLQNKPKMFFIQACRG-----EEMDCGV-EQIDGP-V---RTCSPSCEQRDAGR----------EGQGD-ASARQRGD--MGRIKLPQRSDMIC---GFASLKG O_cuniculus_ENSOCUP00000001859 LELQEVFRLFDNANCPSLQNKPKMFFIQACRG-----DETDRGV-DQQDGK-N---QAGSPGCEESDAGK----------EP---------------LKMRLPTRSDMIC---GYACLK- M_domestica_ENSMODP00000001598 LQLQEVFRLFDNANCPNLQNKPKMFFIQACRG-----DETDRGV-DLRDGK-E---HVASPGCEESDAGK----------EK--------------ILKMRLPTRSDMIC---GYACLKG T_nigroviridis_ENSTNIP00000009934 MEIKSLTSLFRGDRCRSLVGKPKLFFIQACRG-----NDLDGGI-ETDSI------------------------------ED--------------NSTTKIPVEADFLY---AFSTAPG T_rubripes_ENSTRUP00000040691 VELKYLTSLFRGDRCKSLVGKPKLFFIQACRG-----NDLDGGI-ETDSA------------------------------AD--------------SSTTKIPVEADFLY---AFSTAPG T_nigroviridis_ENSTNIP00000010874 LQLDWVFTAFDNAHCPLLQNKPKMFFIQACRG--GSVDEMDCGV-EQIDGP-S---RTGSPSCEQRDAGR----------EGE-------------RPRIKLPQRSDMILRSPRSKSPSG T_guttata_ENSTGUP00000006879 LELKALTSLFRGDRCRSLAGKPKFFFIQACRG-----TELDSGI-ETDSGS-----------------------------EE--------------TMCQKIPVEADFLY---AYSTAPG D_rerio_ENSDARP00000083664 LELDWVFEVFDNARCPLLQNKPKMFFIQACRG-----EEMDNGV-DQLDGQ-E---RTQSPGCEQRDAGR----------EGERDNREKKEEKERERLRVKLPQRSDMIC---GFATLKG G_aculeatus_ENSGACP00000024809 VNLDELTKFVDGNGCRSLVGKPKLLFIQAARG-----NKLDDGT-LSEGDS-M---------------------------DG--------------QTPSRIPVEADFLY---AYSTTPG M_domestica_ENSMODP00000004412 ISVERIVNIFSGSRCPSLGGKPKLFFIQACGG-----DQRDHGF-QVSSNI-P---EDKSPGSDPETDATPFQ---NNFDQP--------------DAVASLPTPSDILV---SYSTFPG G_gallus_ENSGALP00000017288 LELKVLTSLFRGDKCRSLAGKPKLFFIQACRG-----TELDSGI-EADSGP-----------------------------DE--------------TVCQKIPVEADFLY---AYSTAPG E_caballus_ENSECAP00000015102 VSIESIVNIFNGTGCPSLGGKPKLFFIQACGG-----EQKDPGC-KVDSTS-P---EDRTPGSDSEPDAVPFQEGPGTFDQP--------------DAVSSLPTPSDIFV---SYSTFPG E_caballus_ENSECAP00000013731 TPIKDLTGHFRGDRCKTLLEKPKLFFIQACRG-----TELDDGI-QADSGP-I---NDD---T-----------------DA--------------NPRYKVPVEADFLF---AYSTVPG C_familiaris_ENSCAFP00000032189 VDLRKVTGFFRGDYCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGI-E---------------------------DD--------------MACQKIPVEADFLY---AYSTAPG C_familiaris_ENSCAFP00000023821 VELEDLFKVLNNKNCRALRAKPKVYIVQACRG-----EQRDPGE-TV--------------SGDDIVMI-----------TK--------------DNPQTIPTYTDILH---VYSTVEG R_norvegicus_ENSRNOP00000014096 VDLKKLTSFFRGDYCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGT-D---------------------------DD--------------MACQKIPVEADFLY---AYSTAPG M_domestica_ENSMODP00000005556 VELKRLTCFFRGDKCRSLTGKPKLFIIQACRG-----TELDCGV-ETDSGT-D---------------------------ED--------------IACQKIPVEADFLY---AYSTAPG G_aculeatus_ENSGACP00000024812 TSLDDLTKFFKGDRCRSLVGKPKLFFIQACRG-----TDTDRGV-NFDADS-T---------------------------DG--------------QMLQSIPLEADFLY---AYSTPSG O_latipes_ENSORLP00000010095 IELKTLTSLFRGDHCKSLVGKPKLFFIQACRG-----TELDDGI-EADSK----------------------------------------------EDTTKIPVEADFLY---AFSTAPG P_pygmaeus_ENSPPYP00000002138 VSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-----EQKDHGF-EVASTS-P---EDESPGSNPEPDATPFQEGLRTFDQL--------------DAISSLPTPSDIFV---SYSTFPG G_aculeatus_ENSGACP00000024816 EKLDDLTKFFKGDRCRSLVGKPKLFFIQACRG-----TELDEGS-QIEADS-V---------------------------GG--------------QTSDRIPVEADFLY---AYSTAPG O_cuniculus_ENSOCUP00000002346 VKLEDLFEVLNNKNCKALRAKPKVYIVQACRG-----EHRDLGE-TV--------------GEDQVMMI-----------TR--------------DSPQTIPTYTDTLH---VYSTVEG G_aculeatus_ENSGACP00000022402 VPLKSLTSLYRGDRCKSLVGKPKLFFIQACRG-----TELDPGI-EADSVK---------------------------------------------DETTRIPVEADFLY---AFSTAPG T_guttata_ENSTGUP00000017449 IPIEKIVNYFNGSSCPSLRGKPKLFFIQACGG-----EQRDQGF-VVDCDS-P---KEEALGDSLESDAIPFRVPSDNVDEP--------------DAIASLPTPSDILV---SYSTFPG R_norvegicus_ENSRNOP00000017972 VSIERIVNIFNGTGCPSLGGKPKLFFIQACGG-----EQKDHGF-EVAFTS-S---QDKAFDSDSEPDAVPYQEGPRTLDQL--------------DAVSSLPTPSDILV---SYSTFPG B_taurus_ENSBTAP00000028116 VELEDLFQALNNKNCRALRAKPKVYIVQACRG-----EQRDPGE-PV--------------TGGHLVMI-----------TE--------------NTPETIPTYTDTLH---VFSTIEG G_gallus_ENSGALP00000002083 IPIERIVNYFNGSQCPSLRGKPKLFFIQACGG-----EQKDQGF-EVDCES-P---QDETCRRSIESDAIPFQAPSGNEDEP--------------DAVASLPTPGDILV---SYSTFPG M_musculus_ENSMUSP00000030747 VSIEKIVNIFNGSGCPSLGGKPKLFFIQACGG-----EQKDHGF-EVACTS-S---QGRTLDSDSEPDAVPYQEGPRPLDQL--------------DAVSSLPTPSDILV---SYSTFPG M_musculus_ENSMUSP00000091238 VELKKLTSFFRGDYCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGT-D---------------------------EE--------------MACQKIPVEADFLY---AYSTAPG X_tropicalis_ENSXETP00000035938 MPIKVLTTLFRGDKCRSLVGKPKLFFIQACRG-----CEFDDGL-ETDAGP-S---N-DSLET-----------------DA--------------NPRHKIPVEADFLY---AYSTVPG O_anatinus_ENSOANP00000015596 ISVETIVNYFNGSRCPSLGGKPKLFFIQACGG-----EKKDPGF-EVNLDS-P---EDHPTGSDPESDAAPFQAAPEDYDEP--------------DAVASLPTPSDILV---SYSTFPG B_taurus_ENSBTAP00000003205 VSVERIVNTFNGTGCPSLRGKPKLFFIQACGG-----EQKDHGF-EVESTS-P---EDKTPSSDPEADATPFQEGPRSIDEP--------------DAVSSLPTPSDILV---SYSTFPG C_intestinalis_ENSCINP00000002956 IPIESLIKMFDNVNCPPLRNKPKIFFIQCCRG-----NNMDQGI-DATDGP-P---TLNSETSDSYN-----------------------------STTHNITTDVDIIS-----TASKR T_nigroviridis_ENSTNIP00000022078 MPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG-----SEFDDGI-QTDSGP-P---N-DTMET-----------------DA--------------NPRHKIPVEADFLF---AYSTVPG G_aculeatus_ENSGACP00000005791 VAIKELKEPFNGLNCASLAGKPKLFFIQACQG-----TGEQKAV-NVVPDG-P---EDSAVCSD----------------AF--------------KASDAIPSEADFLL---GMSTVPS B_taurus_ENSBTAP00000021099 VNLKKLASFFRGDYCRSLTGKPKLFIIQACRG-----TELDCGI-ETDSGA-E---------------------------DD--------------MACQKIPVEADFLY---AYSTAPG P_troglodytes_ENSPTRP00000056642 VSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-----EQKDHGF-EVASTS-P---EDESPGSNPEPDATPFQEGLRTFDQL--------------DAISSLPTPSDIFV---SYSTFPG D_rerio_ENSDARP00000006831 VDLKSLTSLFRGDRCPSLVGKPKLFFIQACRG-----TELDPGV-ETDHPD-H---------------------------PD------------IPDGRVRIPVEADFLY---AYSTVPG H_sapiens_ENSP00000221740 VKLENLFEALNNKNCQALRAKPKVYIIQACRG-----EQRDPGE-TV--------------GGDEIVMV-----------IK--------------DSPQTIPTYTDALH---VYSTVEG D_rerio_ENSDARP00000071815 IELKRLFAHFRGDRCTSLVGKPKLFFIQACRG-----TDLDSGI-ECDGV------------------------------GD--------------EETQRIPVEADFLY---AYSTAPG T_rubripes_ENSTRUP00000031759 MPIKTMTSMFRGDMCKSLVGKPKLFFIQACRG-----SEFDDGI-QTDSGP-P---N-DTMET-----------------DA--------------NPRHKIPVEADFLF---AYSTVPG M_mulatta_ENSMMUP00000040583 VSVERIVNIFNGTSCPSLGGKPKLFFIQACGG-----EQKDHGF-EVASTS-P---EDESSGSNPEPDATPFQEDLRTFDQL--------------DAVSSLPTPSDIFV---SYSTFPG H_sapiens_ENSP00000365051 VSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG-----EQKDHGF-EVASTS-P---EDESPGSNPEPDATPFQEGLRTFDQL--------------DAISSLPTPSDIFV---SYSTFPG C_familiaris_ENSCAFP00000023986 VSIEKIVNIFNGTGCPSLGGKPKLFFIQACGG-----EQKDHGF-AVASAS-P---EDRSPGSDSEPDAVPFQEGPGPFDQL--------------DAVSSLPTPSDIFV---SYSTFPG M_mulatta_ENSMMUP00000024183 VKLDNLFEALNNKNCQALRAKPKVYIIQACRG-----EQKDPGE-TV--------------GGDEIVMV-----------TK--------------DSPQTIPTYTDALH---VYSTVEG C_familiaris_ENSCAFP00000007585 VNLQDIFEMFNNKNCPALQEKPKIFIIQACRGVLQNTERRDSGV-ET-DDE-PM-ESD----------------------DV--------------SEKRRLPTFSDYFI---IYPTQAD G_aculeatus_ENSGACP00000008661 MPIKSMTSLFRGDMCKSLVGKPKLFFIQACRG-----SEFDDGI-QTDSGP-P---N-DTLET-----------------DA--------------NPRHKIPVEADFLF---AYSTVPG M_domestica_ENSMODP00000018104 IRLDELFCMLTNKNCRALRGKPKVFIVQACRG-----DQKDPGE-VVKPTS-S--------GGD--VLL-----------AK--------------ERPPKLPTFSDSLH---VYATVEG M_domestica_ENSMODP00000005560 VELKELTYFFKGYKCKSLTGKPKLFIIQACQG-----REFDCGV-ETDSGT-D---------------------------ED--------------VACHKIPVEADFLY---AYSTVPG C_intestinalis_ENSCINP00000024485 LSTSKISKSFRPGMCSSLTGKPKIFFFQACQG-----DRTMDGH-SAPVDD-V---ESDGA-------------------AS--------------HGRQVLPSESDFLI---GHSTVPG C_familiaris_ENSCAFP00000016420 TAIKDLTAHFRGDRCRTLLEKPKLFFIQACRG-----TELDDGV-QADSGP-I---N-D---T-----------------DA--------------NPRYKIPVEADFLF---AYSTVPG G_gallus_ENSGALP00000014503 MAIKHLTTLFRGDKCKTLIGKPKLFFIQACRG-----SEFDEGI-QTDSGP-A---N-DTLET-----------------DA--------------NPRYKIPVEADFLF---AYSTVPG R_norvegicus_ENSRNOP00000009643 VRLEDLFEVLNNKNCKALRGKPKVYIIQACRG-----EHRDPGE-EL--------------PGDELAVI-----------KK--------------KNPPTIPTYTDMIH---IYSTVEG T_guttata_ENSTGUP00000011206 MAIKSLTALFRGDKCKSLIGKPKLFFIQACRG-----SEFDEGI-QTDSGP-A---N-DTLET-----------------DA--------------NPRYKIPVEADFLF---AYSTVPG O_latipes_ENSORLP00000010793 VSFNKLIECLKGRSCLSLVGKPKLFFIQACRG-----TLFDEGI-EHDAKD---------------------------------------------DTSEKIPLEADFLF---AYSTVSG X_tropicalis_ENSXETP00000003217 IQIKNLTDLFRGDRCKTLVGKPKLFFIQACRG-----TDLDSGI-ETDSGS-E---------------------------PG--------------EEIQRIPVEADFLY---AYSTVPG D_rerio_ENSDARP00000063081 VSVDEIRNPFTGVNCQKLVGKPKLFFIQACRG-----QRKQLRV-NAQADG-PG-DGESEMEVD----------------GD--------------DFDITIPSDTDFLI---ARSTTDG D_rerio_ENSDARP00000075650 LSIDEIRDPFTGVKCQKLVGKPKLFFIQGCRG-----ANSLQACVKVEADA-----GNSKAKVE----------------GD--------------NLDITIPSDTDFLI---ARSTTNG A_carolinensis_ENSACAP00000002670 VELKMLTSFFRGDKCKSLAGKPKLFFIQACRG-----TELDSGI-ETDSAS-----------------------------DE--------------SMCQKIPVEADYLY---AYSTAPG A_carolinensis_ENSACAP00000009923 MAIKNLTGLFRGDKCQSLIGKPKLFFIQACRG-----SEFDAGI-QTDSGS-S---N-DNLEM-----------------DA--------------NPRYKIPVEADFLY---AYSTVPG G_aculeatus_ENSGACP00000023055 ISVQDITSLFKGDKCKSLVGKPKIFILQACRG-----DKHDDPV-TACDAV-----DSELKTNEVVV-------------DA--------------SVLHTLPAGADFIM---CYSVAEG C_intestinalis_ENSCINP00000007986 VAIDTVVNFFSNQNCHSLQKKPKIFLFQACQG-----DEYDMGV-DEVDGP-V---QAPVGDVDNTSTSSS---------ND--------------HIRNKLPQKSDMLI---GQATMKG T_guttata_ENSTGUP00000004278 IEIQTITDMFRGDKCQSLVGKPKIFIIQACRG-----DKHDDAV-IAHDSA-D---GSESPGNETDV-------------DA--------------AGVYTLPAGADFIM---CYSVAQG T_rubripes_ENSTRUP00000044662 VEIRKLMEPFSGTNCPSLAGKPKIFFIQACQG-----SRQQDIV-YTDAGT-P---GHGYVDNN----------------AV--------------QAKECIPSHADFLL---GMATVPS A_gambiae_AGAP004920-PA FNVDRLWENFIGDSCPSLLGKPKLFFIQACRG-----SSFDTGV-HFSQCM-T---QVAKTVVPYAMRELPQPSIVPGCPKS--------------SIQYAIPSMADLLV---MYSTYKG D_rerio_ENSDARP00000019984 MPIKTMTSLFKGDVCKSLVGKPKLFFIQACRG-----SEFDDGV-QTDSGP-P---N-DTIET-----------------DA--------------NPRHKIPVEADFLF---AYSTVPG M_domestica_ENSMODP00000032734 VNLSDIFEMFNNENCPALQEKPKIFVIQACRG-----DKRDGGV-VQADDE-PM-EL-----------------------DL--------------SEKKRLPTSSDYYI---IYATQDD B_taurus_ENSBTAP00000012869 VSLEDIFEMFNNKNCPALQEKPKIFIIQACRG-----ERRDSGV-ET-DDE-PM-DLD----------------------DG--------------SEKKRLPTFSDYFI---VYPTQAD E_caballus_ENSECAP00000021726 IPIREIMSHFTAQRCPALAHKPKLFFIQACQG-----EEVQPSV-SIEADA-V---NPENVTP---------------------------------SLEDSVPVEADFLL---GLATVPG B_taurus_ENSBTAP00000008706 TAIKDLTAHFRGDRCKTLLEKPKLFFIQACRG-----TELDDGI-QADSGP-I---N-D---T-----------------DA--------------NPRYKIPVEADFLF---AYSTVPG M_musculus_ENSMUSP00000026062 TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG-----TELDDGI-QADSGP-I---N-D---I-----------------DA--------------NPRNKIPVEADFLF---AYSTVPG D_rerio_ENSDARP00000024255 VPFKELMETLSPFRCSSLYQKPKLFFIQACRG-----TQNQRAV-FPQTFT-E---DEDVLASD----------------AG--------------VPRDSIPEMADYLM---AMSTVPW A_carolinensis_ENSACAP00000013788 ISLDGIFSLFNNKTCPKLQGKPKIFIIQACRG-----EQRDYGT-LVAGGK-PV-EP-----------------------DT--------------WSRPKLPTVSDYFI---VYSSQRD M_musculus_ENSMUSP00000005488 VRLEDLFEVLNNKNCKALRGKPKVYIIQACRG-----EHRDPGE-ELRGNE-EL-GGDEELGGDEVAVL------------K--------------NNPQSIPTYTDTLH---IYSTVEG R_norvegicus_ENSRNOP00000022693 TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRG-----TELDDGI-QADSGP-I---N-D---T-----------------DA--------------NPRYKIPVEADFLF---AYSTVPG A_gambiae_AGAP011949-PA LRIDKLWASFVGNKCPSLIGKPKLVFIQTCRG-----DNVDFGV-ASHETD-STPCS-----------------------VD--------------PAPGIIPMYADLLV---MYSSYDR 610 620 630 640 650 660 670 680 690 700 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+= H_sapiens_ENSP00000364878 --NVSWRHETNGSVFISQIIYYFREYS-WSHHLE--EIFQKVQHSFETP-----------NILTQLPTIERL----SMTRYFYLFPGN------------- P_troglodytes_ENSPTRP00000047678 --NVSWRHETNGSVFISQIIYYFKEYS-WSHHLE--EIFRKVQHSFETL-----------NILTQLPTIERL----SMTRYFYLFPGN------------- P_pygmaeus_ENSPPYP00000004372 --NVSWRHEINGSVFISQIIYYFKEYS-WSHHLE--EIFRKVQHSFENP-----------SILTQLPTIERL----SMTRYFYLFPGN------------- M_mulatta_ENSMMUP00000021744 --NVSWRHEISGSVFISQIIYYFKEYS-WSHHLE--EIFRKFERSFETP-----------NVVTQLPTIMLI----SIFIYFILF---------------- E_caballus_ENSECAP00000006810 --NISWRTDKTGSIFISKLIYNFRKYS-CCHHLE--EIFRKVQRSFEIP-----------SVVIQMPTIERV----SMTRYFYLFPGN------------- G_gorilla_ENSGGOP00000011776 --XXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX--XXXXXVQHSFETP-----------NVLTQLPTIERL----SMTRYFYLFPGN------------- C_familiaris_ENSCAFP00000021904 --NVSWRLNTDGSLFISHLIHYFREFS-CCHHLE--EIFRKVQNSFETP-----------NTMIQMPTIERV----SMTRYFYLFPGN------------- M_musculus_ENSMUSP00000027009 --NISWKVGKTGSLFISKLIDCFKKYC-WCYHLE--EIFRKVQHSFEVP-----------GELTQMPTIERV----SMTRYFYLFPGN------------- R_norvegicus_ENSRNOP00000029448 --NISWKVGKSGSLFISKLIDCFKKYC-WCYHLE--EIFRKVQYSFEVP-----------GELTQMPTIERV----SMTRYFYLFPGN------------- P_pygmaeus_ENSPPYP00000004373 --NVSWRDSTMGSIFITQLITCFQKYS-WCCHLE--EVFRKVQQSFETP-----------RAKAQMPTIERL----SMTRYFYLFPGN------------- P_troglodytes_ENSPTRP00000041705 --NVSWRDSTMGSIFITQLITCFQKYS-WCCHLE--EVFRKVQQSFETP-----------RAKAQMPTIERL----SMTRYFYLFPGN------------- B_taurus_ENSBTAP00000027820 --NVSWRDIKKGSLFITRLITCFQKYA-WCCHLE--EVFRKVQQSFEKP-----------NVKAQMPTVERL----SMTRYFYLFPGN------------- C_familiaris_ENSCAFP00000031565 --NVSWRHITKGSLFIAQLITCFQKYS-WCCHLE--GVFRKVQQSFEKP-----------DVKAQMPTIERV----SMTRYFYLFPGN------------- H_sapiens_ENSP00000347741 --NVSWRDSTMGSIFITQLITCFQKYS-WCCHLE--EVFRKVQQSFETP-----------RAKAQMPTIERL----SMTRYFYLFPGN------------- M_mulatta_ENSMMUP00000012893 --NVSWRDSTMGSVFITQLITCFQKYS-WCCHLE--EVFRKVQQSFETP-----------RAKAQMPTIERL----SMTRYFYLFPGN------------- E_caballus_ENSECAP00000010831 --NVSWRDITKGSLFITQLITCFQRHS-WCCHVE--EVFRKVQQSFEKP-----------SIKTQMPTTERQ----SMTRYFYLFPGN------------- M_domestica_ENSMODP00000034020 --NVSWRHPRNGSVFITKLIHYFQQYC-WCYHIE--EIFRKVQNAFETP-----------EYKFQMPTIERL----SMTRYFYLFPGN------------- M_domestica_ENSMODP00000034022 --NISWRNIYKGSLFIIQLILYIKKFA-WCYHLY--EIFCKVQHSFETP-----------AEKLQMPTIERA----TLTKYFYLFPGN------------- M_mulatta_ENSMMUP00000012894 --NMSWRDRTKGSIFITELITCFQKYS-WCYHLM--KIFQKVQKSFEIP-----------MAKAQMPTIERV----SLTRDFYLFPGN------------- P_troglodytes_ENSPTRP00000007279 --NVSWRDCTRGSIFITELITCFQKYS-CCCHLM--EIFRKVQKSFEVP-----------QAKAQMPTIERA----TLTRDFYLFPGN------------- H_sapiens_ENSP00000376849 --NVSWRDRTRGSIFITELITCFQKYS-CCCHLM--EIFRKVQKSFEVP-----------QAKAQMPTIERA----TLTRDFYLFPGN------------- E_caballus_ENSECAP00000021890 --TVSWRSPTTGSVFIEKLIENLQEYA-WSCDLE--EIFRKVRLSFELP-----------DARAQMPTAERV----TLTRRFYLFPGY------------- H_sapiens_ENSP00000260309 --NVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVE--EIFRKVRFSFEQP-----------DGRAQMPTTERV----TLTRCFYLFPGH------------- P_troglodytes_ENSPTRP00000059619 --NVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVE--EIFRKVRFSFEQP-----------DGRAQMPTTERV----TLTRCFYLFPGH------------- P_pygmaeus_ENSPPYP00000004374 --NVSWRDRTRGSIFIMELITCFQKYS-CCCHLM--EIFRKVQKSFEVP-----------QAKAQMPTIERA----TLTRDFYLFPGN------------- M_domestica_ENSMODP00000034033 --NVSWRNIYKGSLFIIQLILYIKKFA-WCYHLY--EIFCKVQHSFENR-----------EEKLQMPTIERA----TLTKYFYLFPGN------------- G_gorilla_ENSGGOP00000015374 --XVSWRDRTRGSIFITELITCFQKYS-CCCHLM--EIFRKVQKSFEVP-----------QAKAQMPTIERA----TLTRDFYLFP--------------- P_pygmaeus_ENSPPYP00000004377 --NVSWRHPTMGSVFIMRLIQHMQEYA-CSCDVE--EIFRKVRFSFEQP-----------DGRAQMPTTERV----TLTRCFYLFPGH------------- B_taurus_ENSBTAP00000027821 --NVSWRHPIFGSLFIIKLIETFQEYA-WSCDLE--EIFRKVRFSFELP-----------DGKVQMPTAERV----TLTRCFYLFPGY------------- M_musculus_ENSMUSP00000027012 --HLSYRDKTGGSYFITRLISCFRKHA-CSCHLF--DIFLKVQQSFEKA-----------SIHSQMPTIDRA----TLTRYFYLFPGN------------- R_norvegicus_ENSRNOP00000009993 --NVSWRHPVQGSLFIESLIKHMKEYA-WSCDLE--DIFRKVRFSFEQP-----------DSRLQMPTTERV----TLTKRFYLFPGH------------- M_musculus_ENSMUSP00000027015 --NVSWRHPVRGSLFIESLIKHMKEYA-WSCDLE--DIFRKVRFSFEQP-----------EFRLQMPTADRV----TLTKRFYLFPGH------------- O_anatinus_ENSOANP00000016591 --HVSWRDPKTGSLFIVQLIKCFQNHA-WNCDLE--SLFLKVQRHFETP-----------KQKLQMPTRERA----TLTKRFFLFPGH------------- O_cuniculus_ENSOCUP00000000956 --NVSWRHPKQGSLFIMRLIKTMQEYA-WSCDVE--EIFRKVRFSFELP-----------EGRTQMPTTERV------MRRFYLFP-H------------- R_norvegicus_ENSRNOP00000058685 --HYSYTDWPRGSYXSSKCIFCLRMXT-XTVYLY--ELHNNVQQSFEKA-----------SINSQMPTIDRA----TLTRYFYLFPGN------------- M_mulatta_ENSMMUP00000012901 --NVSWRHPTKGSVFIIRLIEHIQEYA-CSCDVE--EIFRKVRLSFEQP-----------SGRVQMPTTERV----TLTRCFYLFPGH------------- G_gallus_ENSGALP00000001569 --TVSWRSPTEGSVFIQRLVEQFRNHA-FNSDLQ--EMFRKVQRSFE-------------NFPRQLPTQERT----TMLKKFYLFPGL------------- X_tropicalis_ENSXETP00000017024 --TVSWRHPTMGSLFITGLIKKMNELA-HCQPLM--DIFLEVQSSFKGQ--------------RQMPTQERS----TLTKKFYLFPGH------------- G_aculeatus_ENSGACP00000013201 --TVSYRHPVNGSFLIQYVVEVFNTFA-REDHVE--ELFRKVMQRFEDFPI---------QREKQMPTKDRC----TLTKHFYFFPGL------------- A_carolinensis_ENSACAP00000013361 ----------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000006490 --NLS------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000034228 --TKSYRHVQNGTFYVQTLVDVFIKCA-HEDHIE--ELFRKVLRRFEHPNMI--------GNFKQMACKDRA----TLPKLFYLFPGL------------- T_rubripes_ENSTRUP00000019853 --TVSYRSPAKGSFLVQFLVDVFNASA-ERDDLE--ELFRKVQRRFEDYSIGD-------RSLRQMPAKDRG----TMTKRFYFYPGL------------- T_rubripes_ENSTRUP00000035020 --TVSYRALAKGSFLVQVLVDVFNASA-ERDDLE--ELFRKVQHRFEDFPIGN-------R--RQMPTRDRC----TLTKRFYFYPGL------------- O_latipes_ENSORLP00000007938 --TKAFRCRARGSHLIQYIVEIFNTDA-DTLYIQ--ELFRKVMLRFESFAF---------KHNRQMATIERC----TLLKQFYFYPGLGDTNHS------- T_rubripes_ENSTRUP00000013027 --TVSYRALAKGSFLVQVLVDVFNASV-ERDDLE--ELFRKVQHRFEDFPIGN-------R--RQMPTKDRC----TLTKRFYFYPGL------------- D_rerio_ENSDARP00000059407 --VVAYRDEVKGSYFISYIVDVFCSSA-CKDHIM--ELFRKVAARMEKDERFR-------RQAKLLPCIERT----SLVKKFYLFPGQ------------- D_rerio_ENSDARP00000068268 --TFAYRNPIEGSFFISYIVDVFCSSA-HRDDIM--ELFRKVTLRMEKDQRFQ-------GQAKLLPCIERT----SISKRFYLFPGL------------- D_rerio_ENSDARP00000008601 --TVS-------------------------------DPLLQGK---------------------------------------------------------- C_elegans_C48D1.2 --YVSWRNSARGSWFIQAVCEVFSTHA-KDMDVV--ELLTEVNKKVACGFQTS----QGSNILKQMPEMTS-----RLLKKFYFWPEARNSAV-------- G_gallus_ENSGALP00000029853 --TAAMRNTKRGSWYIEALTTVFAEDS-RDTHVA--DMLVKVNRQIKQREGYA--PGTEFHRCKEMSEYCS-----TLCRDLYLFPGYVPGK--------- A_carolinensis_ENSACAP00000006831 --TAAMRNTKHGSWYVEALTSVFAEDS-GHMHVA--DMLVKVNRLIKLREGHA--PGTEFHRCKEMSEYCS-----TLCQDLYLFPGYFPG---------- D_rerio_ENSDARP00000075318 --YVSIRDRTSGTWFIQSLCENLKEGSKRGHDIL--MILTKVNNDVSRKEGSL-KVKNEIVDAKVTPQPIF-----TLRKLLIFRPLKKTGRFS------- X_tropicalis_ENSXETP00000015203 --TVSLRNTKRGSWFVQDLVSVFSQYS-KNTHVA--DMLVKVNALIKEREGHA--PGTEFHRCKEMSEYCS-----TLCRDLYLFPG-------------- M_musculus_ENSMUSP00000031895 --NAAMRNTKRGSWYIEALTQVFSERA-CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCQQLYLFPGYPPT---------- R_norvegicus_ENSRNOP00000022672 --NAAMRNTKRGSWYIEALTQVFSERA-CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCQQLYLFPGYPPT---------- E_caballus_ENSECAP00000003321 --TAAMRNTKRGSWYIEALTQVFSERA-CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- B_taurus_ENSBTAP00000024166 --TAAMRNTKRGSWYVEALTQVFSERA-CDMHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- O_anatinus_ENSOANP00000005545 --TAAMRNTKRGSWYIEALTQVFAESA-RDMHVA--DMLVKVS---------------------------------------------------------- H_sapiens_ENSP00000312664 --TAAMRNTKRGSWYIEALAQVFSERA-CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- P_troglodytes_ENSPTRP00000033921 --TAAMRNTKRGSWYIEALAQVFSERA-CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- P_pygmaeus_ENSPPYP00000017020 --YYSWRNSKDGSWFIQSLCAMLKQYA-DKLEFM--HILTRVNRKVATEFESF-SLDATFHAKKQIPCIVS-----MLTKELYF-Y---H----------- M_mulatta_ENSMMUP00000016588 --TAAMRNTKRGSWYIEALAQVFSERA-CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- O_anatinus_ENSOANP00000000517 --YYSWRNSMNGSWFIQALCAMLKQHA-HTLELL--HILTRVNRKVATEFESY-SLDATFNAKKQIPCIVS-----MLTKELYF-P---Y----------- T_rubripes_ENSTRUP00000037606 QDSSHAEHQKRGSWFIQELNTALRLHA-RDRHLA--DILVQVNRRIKDREGYA--PGTAHHRCKEMSEFTS-----SLCKDLFLFPKYQPQ---------- C_familiaris_ENSCAFP00000005409 --TAAMRNTKRGSWYIEALTQVFSERA-CDTHVA--DMLVKVNALIKEREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- E_caballus_ENSECAP00000019797 --YYSWRNSKDGSWFIQSLCAMLKLYA-HKLELM--HILTRVNRKVAMEFESY-CLDPTFHGKKQIPCIVS-----MLTKELYF-Y---H----------- T_guttata_ENSTGUP00000013612 --TAAMRNTKRGSWYVEALTSVFAEDS-QHTHVA--DMLVKVNRQIKQREGYA--PGTEYHRCKEMSEYCS-----TLCRDLYLFPGYLPGK--------- P_troglodytes_ENSPTRP00000054330 --YYSWRNSKDGSWFIQSLCAMLKQYA-DKLEFM--HILTRVNRKVATEFESF-SFDATFHAKKQIPCIVS-----MLTKELYF-Y---H----------- H_sapiens_ENSP00000311032 --YYSWRNSKDGSWFIQSLCAMLKQYA-DKLEFM--HILTRVNRKVATEFESF-SFDATFHAKKQIPCIVS-----MLTKELYF-Y---H----------- P_pygmaeus_ENSPPYP00000020323 --TAAMRNTKRGSWYIEALAQVFSERA-CDMHVA--DMLVKVNALIKDREGYA--PGTEFHRCKEMSEYCS-----TLCRHLYLFPGHPPT---------- E_caballus_ENSECAP00000010379 --YIAYRHDKEGSCFIQTLVDVFTE---RRGPIL--ELLTEVTRRMAEAELVQ-----EGRTRKVNPEIQS-----TLRKRLYLQ---------------- M_mulatta_ENSMMUP00000015808 --YYSWRNSKDGSWFIQSLCAMLKQYA-DKLEFM--HILTRVNRKVATEFESF-SLDATFHAKKQIPCIVS-----MLTKELYF-Y---H----------- O_latipes_ENSORLP00000015114 --TAAMRNTKKGSWFIQELNTALRLNA-RDTHLA--DILVQVNKRIKEREGYA--PGTAHHRCKEMSEFTS-----SLCKDLYLFPKYQPQC--------- G_aculeatus_ENSGACP00000013740 --TAAMRNTKRGSWFVQELNKRLRLHA-RDTHLA--DIMVQVNRHIKEREGYA--PGTAHHRCKEMSEFTS-----SLCKDLYLFPKYQPQ---------- O_cuniculus_ENSOCUP00000001859 ----------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000001598 --TAAMRNTKRGSWYIEALTQVFSERA-RDMHVA--DML--VNALIKDREGYA--PGTEFHRSKEMSEYSS-----TLCRHLYLFPGHPPT---------- T_nigroviridis_ENSTNIP00000009934 --YYSWRNTMSGSWFMQSLCDTISKYG-KELELQ--HILTRVNHKVAVEFESD-SSLPGFNAKKQIPCIVS-----MLTKEMYF-S--------------- T_rubripes_ENSTRUP00000040691 --YYSWRNTTSGSWFMQSLCDAISKYG-KELELQ--HILTRVNHKVAVDFESV-SNLPGFDAKKQIPCIVS-----MLTKEMYF-S--------------- T_nigroviridis_ENSTNIP00000010874 --TAAMRNTKRGSWFIQELNKALRLHA-RDKHLCRHSGAGKVNSRIKEREGHA--PGTAHHRCKEMSEYTS-----SLCKDLFLFPKYQPQY--------- T_guttata_ENSTGUP00000006879 --YYSWRNSAEGSWFIQSLCKMLKEHA-RKLELM--QILTRVNRRVA-EYESC-STRQDFNAKKQIPCIVS-----MLTKEFYF-PS-------------- D_rerio_ENSDARP00000083664 --TAAMRNTKKGSWFIQELNTAIRQRA-NNTHLS--DILVQVNGQIKSREGYA--PGSAHHRCKEMSEFTS-----SLCKDLYLFPKYYPSN--------- G_aculeatus_ENSGACP00000024809 --FNAWRDTQNGSWFMQSLCEMLRRFS-GQLELM--QIMTRVNNKVALEYKTT----PGRSGKRQMPCIVS-----LLTKEFYF-P--------------- M_domestica_ENSMODP00000004412 --FVSWRDPKSGSWYIETLDRVLEEWA-DREDLL--HMLLMVSNAVSAR-----------GTYKQIPGCFN-----FLRKRFFF-KTK------------- G_gallus_ENSGALP00000017288 --YYSWRNAAEGSWFIQSLCRMLKEHA-RKLELM--QILTRVNRRVA-EYESC-STRQDFNAKKQIPCIVS-----MLTKEFYF-PC-------------- E_caballus_ENSECAP00000015102 --FVSWRDPKSGSWYVETLDGVFEQWA-HSEDLQ--TLLLRVAHAVSEK-----------GVYKQIPGCFN-----FLRKKFFF-KTY------------- E_caballus_ENSECAP00000013731 --YYSWRNPGSGSWFVQALCSILNEHG-KSLEII--QILTRVNHRVARHFESH-SDDPRFHQKKQIPCVVS-----MLTKELYF----------------- C_familiaris_ENSCAFP00000032189 --YYSWRNSKDGSWFIQSLCAMLKLYA-HKLEFM--HILTRVNRKVATEFESF-SLDSAFHGKKQIPCIVS-----MLTKELYL-Y---H----------- C_familiaris_ENSCAFP00000023821 --YIAYRHDKEGSCFIQTLVDVFTE---RKGPIL--ELLTEVTRRMAEAELVQ-----EGKPRKVNPEIQS-----TLRKRLYLQ---------------- R_norvegicus_ENSRNOP00000014096 --YYSWRNSRDGSWFIQSLCAMLKLYA-HKLEFM--HILTRVNRKVATEFESF-SLDATFHAKKQIPCIVS-----MLTKELYF-Y---H----------- M_domestica_ENSMODP00000005556 --YYSWRNSKDGSWFIQALCAVLKQHA-HKLEIM--QILTRVNRKVATEFESY-SLDISFHAKKQVPCIMS-----MLTKELYF-S---H----------- G_aculeatus_ENSGACP00000024812 --YYSWRNTQNGSCFMQSLCEILHSFS--QLELM--QIMTRVNYEVALHFESS-SDKLGYSGKKQIPCIMS-----MLTKDFYF-P---K----------- O_latipes_ENSORLP00000010095 --YYSWRNTMTGSWFINSLCEMLSKYG-KELELL--HIMTRVNHMVAVEFESI-STLPGFHAKKQIPCIVS-----MLTKEMYFYP--------------- P_pygmaeus_ENSPPYP00000002138 --FVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQ--SLLLRVANAVSVK-----------GIYKQMPGCFN-----FLRKKLFF-KTS------------- G_aculeatus_ENSGACP00000024816 --YYAWRNTQNGSWFMQSLCEMLRRFS-GQLELM--QIMTRLNHRVALHFESS-SDTPGYSGKKQIPCIVS-----MLTKDFYF-P---K----------- O_cuniculus_ENSOCUP00000002346 --YIAYRHDQEGSCFIQTLTDVFMN---RTGPIL--ELLTEXXXXXXXXXXXQ-----EGKARKVNPEIQS-----TLRKRLYLQ---------------- G_aculeatus_ENSGACP00000022402 --YYSWRNTTTGSWFMQSLCDMISKYG-KELELQ--HIMVRVNHKVAVAFESV-SNSPDFNARKQIPCVVS-----MLTKEMYFSP--------------- T_guttata_ENSTGUP00000017449 --FVSWREKSSGSWYVETLDSVLEQYA-HSEDLL--SMLVRVAHAVSAR-----------GRYKQIPGCFN-----FLRKKFFF-VCR------------- R_norvegicus_ENSRNOP00000017972 --FVSWRDKKSGSWYIETLDGVLEQWA-RSEDLQ--SLLLRVANAVSEK-----------GVYKQIPGCFN-----FLRKKLFF-KLH------------- B_taurus_ENSBTAP00000028116 --YIAYRHDQEGSYFIQTLVDVFIN---KKGPIL--ELLTEVTRRMAEAEMVQ-----EGEAKKVNPEIQS-----TLRKQLYLQ---------------- G_gallus_ENSGALP00000002083 --FVSWRDKVSGSWYVETLDSVLEHYA-RSEDLL--TMLLRVSDIVSTK-----------GRYKQIPGCFN-----FLRKKFFF-LCK------------- M_musculus_ENSMUSP00000030747 --FVSWRDKKSGSWYIETLDGILEQWA-RSEDLQ--SLLLRVANAVSAK-----------GTYKQIPGCFN-----FLRKKLFF-KTS------------- M_musculus_ENSMUSP00000091238 --YYSWRNSKDGSWFIQSLCSMLKLYA-HKLEFM--HILTRVNRKVATEFESF-SLDSTFHAKKQIPCIVS-----MLTKELYF-Y---H----------- X_tropicalis_ENSXETP00000035938 --YYSWRNPGRGSWFVQALCNVLNEHG-KELEVM--QILTRVNYLVATQFESY-CDDPQFNKKKQIPCVVS-----MLTKELYF-K--PC----------- O_anatinus_ENSOANP00000015596 --FVSWRDTQSGSWYIETLDSVLDQWA-HTEDLL--TLLLRVSNGVSSK-----------GKYKQIPGCFN-----FLRKRLFF-NTK------------- B_taurus_ENSBTAP00000003205 --FVSWRDPKSGSWYIETLDSIFEQWA-HCEDLQ--TLLLRVANAVSVK-----------GIYKQMPGCFN-----FLRKKLFF-KT-------------- C_intestinalis_ENSCINP00000002956 --NAALRNTRHGSWYIQVLVKTIAQHA-HEMDLL--EILTLVNSAIKSKEGHS--TDFDSQGVKEMSEFHS-----TLCKKLFFYPGIVQTE--------- T_nigroviridis_ENSTNIP00000022078 --YYSWRNPGRGSWFVQALCNVLNEFG-KQLEIM--QILTRVNYMVATSFESW-SEDPRFSEKKQIPCVVS-----MLTKELYF-K--PC----------- G_aculeatus_ENSGACP00000005791 --FVSYRHRKNGSWFIESLCQNLVQMV---------------------------------------PKL-------------------------------- B_taurus_ENSBTAP00000021099 --YFSWRNAKNGSWFIQALCEMLKKHA-HRLELM--HILTRVNRKVAIEYESF-STDSAFHAKKQIPCIMS-----MLTKELYF----------------- P_troglodytes_ENSPTRP00000056642 --FVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQ--SLLLRVSAAFLCK-----------GEGRLLRGSVSSWGWGFGVSRAGP-NQG------------- D_rerio_ENSDARP00000006831 --YYSWRNTMTGSWFIQSLCEMMTKYG-SELELL--QIMTRVNHKVALDFEST-SNMPGFDAKKQIPCIVS-----MLTKEMYFTP--------------- H_sapiens_ENSP00000221740 --YIAYRHDQKGSCFIQTLVDVFTK---RKGHIL--ELLTEVTRRMAEAELVQ-----EGKARKTNPEIQS-----TLRKRLYLQ---------------- D_rerio_ENSDARP00000071815 --YYAWRNVANGSWFISSLCDMLLKYG-KQLEIM--QVMTRVNHKVALEFESS-SNLPGFDGKKQIPCIVS-----MLTKELYF-P---K----------- T_rubripes_ENSTRUP00000031759 --YYSWRNPGRGSWFVQALCNVLSEFG-KQLEIM--QILTRVNYMVATSFESW-SEDPRFSEKKQIPCVVS-----MLTKELYF-K--QC----------- M_mulatta_ENSMMUP00000040583 --FVSLRDPKSGSWYIETLDNIFEQWA-HSEDLQ--SLLLRVADAVSVK-----------GIYKQMPGCFN-----FLRKKLFF-KTS------------- H_sapiens_ENSP00000365051 --FVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQ--SLLLRVSAAFLCK-----------GEGRLLRGSVSSWGWGFGVSRAGP-NQG------------- C_familiaris_ENSCAFP00000023986 --FVSWRNTKSGSWYVETLDGVFEQWA-HAEDLQ--TLLLRVANAVSQK-----------GVYKQIPGCFN-----FLRKKLYF-KM-------------- M_mulatta_ENSMMUP00000024183 --YIAYRHDQKGSCFIQTLVDVFTK---GKGHIL--ELLTEVTRRMAEAEMVQ-----EGQAKKTNPEIQS-----TLRKRLYLQ---------------- C_familiaris_ENSCAFP00000007585 --HVALRHPRTGSVMIEAMSEVFKQYG-NKWHIA--DFFTRVNNRVVHTEFHL-----HEEPIKVSLVMES-----TLTKSVYF----------------- G_aculeatus_ENSGACP00000008661 --YYSWRNPGRGSWFVQALCNVLNEFG-KQLEIM--QILTRVNYMVATSFESW-SEDPRFSEKKQIPCVVS-----MLTKELYF-N--------------- M_domestica_ENSMODP00000018104 --YIAYRHEEDGSFFIQTLVDVFTN---MKGNIL--DLLTEVTRRMADAELME-----EGKPRKVNPEVQS-----TLRKLLYL----------------- M_domestica_ENSMODP00000005560 --YYSLRDPKDGSWFIQALCAVLKQHA-HKLEIM--QILTRVNRKVATEFESY-SSKASLHAKKQMPCIMS-----MLTKELYF-S---H----------- C_intestinalis_ENSCINP00000024485 --YLSYRSRTDGSWFISTLVDSLEKYH-EKEDLL--SIMINVNQEMASK------------PYKQMPMPIA-----TLRKKVFF-SKQNSNSSSNQNCNTP C_familiaris_ENSCAFP00000016420 --YYSWRSPGSGSWFVQALCSTLNEHG-KSLEIL--HILTRVNNRVARHFESQ-SDDPHFHEKKQIPCVVS-----MLTKELYF----------------- G_gallus_ENSGALP00000014503 --YYSWRNPGRGSWFVQSLCSVLNEHG-KQLEIM--QILTRVNYVVATNFESQ-SDDPRFSEKKQIPCVVS-----MLTKELYF----------------- R_norvegicus_ENSRNOP00000009643 --FLSYRHDQKGSGFIQTLTDVFIH---KKGSIT--ELLEEITRLMANTEVMQ-----EGKPRKVNPEIQS-----TLRKKLYLQ---------------- T_guttata_ENSTGUP00000011206 --YYSWRNPGRGSWFVQSLCSVLNEHG-KQLEIM--QILTRVNYVVATNFESQ-SDDPRFSEKKQIPCVVS-----MLTKELYF----------------- O_latipes_ENSORLP00000010793 --YYSWRSTANGSWFIQSLCEMLEKFS-KTLDLM--QIMTRVNHKVATHFESS-SNAPGFSGKKQIPCIVS-----MLTKDFYF-PYESN----------- X_tropicalis_ENSXETP00000003217 --YYSWRNTMNGSWFIQSLCEMIKLYG-PHLELI--QILTCVNHMVALEFESC-STQQAFHAKKQIPCVVS-----MLTKAFYFLK--------------- D_rerio_ENSDARP00000063081 --HVSYRKPDEGSWFIQSLCRNLEKHCPLGADIL--TILLSVNNEVSIQ----------GLHSKQMPVHEV-----AMRMKLILPPVNN------------ D_rerio_ENSDARP00000075650 --HVSYRHVREGSWFIQSLCRNLEKHCPRGADIL--TILLYVNNEVSSQ----------KSIRKQMPIYEV-----ALTRKLFLRPVNP------------ A_carolinensis_ENSACAP00000002670 --YYSWRNSSDGSWFIQSLCSMLKQYS-HKLELM--QILTRVNRKVT-EFTSC-SNHPDFHGKKQIPCIMS-----MLTKDFYF-P---H----------- A_carolinensis_ENSACAP00000009923 --YFSWRNPGKGSWFVQSLCSVLNDHG-KELEVL--QILTMVNYKVARNYESQ-SDDPRFSQKKQVPCVVS-----MLTKELYF----------------- G_aculeatus_ENSGACP00000023055 --YYSHRETINGSWYIQDLCELLQRYG-DSHEFT--EVLTLVNRKVSMRSVGN-SSDRSAIGKKQVPCFAS-----MLTKKLYFRPKQ------------- C_intestinalis_ENSCINP00000007986 --FAAMRNTKHGSWYIQAFVRVLARHA-CDTDLL--DMMTKVNNILKHKEGWC--PGSVYHRCKVMPEFKS-----SLSKKLYFFPGI------------- T_guttata_ENSTGUP00000004278 --YYSHRDTINGSWYIQDLCETLRKHG-SSLEFA--ELLTVVNRKVSCRRVGM-CKDINAIGKKQIPCFAS-----MLTKKLYFHPKSK------------ T_rubripes_ENSTRUP00000044662 --FVSFRDGTHGTWYIQSLCQNLADMVPRGCDLI--SILTKVNADVSKKVAWI-----DSGHKTQMPQPAF-----TLTKKIVF-PAPNTPHPV------- A_gambiae_AGAP004920-PA --HYSWRNPSTGSWFIRALCDELREHG-NSKELL--QLLTSVSRRVAYEFQSNVPNNSQIDCQKQMPCIVS-----MLTRRIYFSKK-------------- D_rerio_ENSDARP00000019984 --YYSWRNPGRGSWFVQALCNVLSEFG-KQLEIM--QILTRVNYMVATSFESW-SEDPRFSEKKQIPCVVS-----MLTKELYF-N--------------- M_domestica_ENSMODP00000032734 --HVAFRHPRDGSVMIQAIDEVFRQHG-KKWHIA--DFFTQVNNLVVHTDFYI-----NRNPAKVVLVMES-----TLTKAVYF----------------- B_taurus_ENSBTAP00000012869 --HVALRDPRTGSVMIKEMTEVFKQYG-NKWHLA--DFFTIVNNRVVHRDFNL-----CNKPVKVSLVMES-----TLTKFVYF----------------- E_caballus_ENSECAP00000021726 --YVSFRHVKEGSWYIQSLYNNLKDLVPRREDIL--SILTAVNDDVSRQVD-------IYGKKKQMPQPAF-----TLRKKLVF-PVP------------- B_taurus_ENSBTAP00000008706 --YYSWRNPGSGSWFVQALCSILNEHG-KSLEIL--QILTRVNDRVARHFESQ-SDDPRFHEKKQIPCVVS-----MLTKELYF----------------- M_musculus_ENSMUSP00000026062 --YYSWRNPGKGSWFVQALCSILNEHG-KDLEIM--QILTRVNDRVARHFESQ-SDDPRFNEKKQIPCMVS-----MLTKELYFSR--------------- D_rerio_ENSDARP00000024255 --YASYRDKSKGTWFIQSLCDNLRLLVPRGNDLL--SILTKVNADVSKKSD-------KSGLKKQMPQPEF-----SLTRTVVFPPPGLP----------- A_carolinensis_ENSACAP00000013788 --HIAVRDENTGSEMISAMDEVFSEHG-TQWHIG--DLFTKVNSKMIQRDFHL---EGEEESVKVTIVMES-----TLTKALYL----------------- M_musculus_ENSMUSP00000005488 --YLSYRHDEKGSGFIQTLTDVFIH---KKGSIL--ELTEEITRLMANTEVMQ-----EGKPRKVNPEVQS-----TLRKKLYLQ---------------- R_norvegicus_ENSRNOP00000022693 --YYSWRNPGKGSWFVQALCSILNEHG-KDLEIM--QILTRVNDRVARHFESQ-SDDPRFNEKKQIPCMVS-----MLTKELYFGR--------------- A_gambiae_AGAP011949-PA --HISVRCKDKGSWFIQSLCQVLRANI-AGKELI--SLLTQVSYIVSCQTSIT----SDGETVKQIPSINS-----MLTKAFYFVPKQTQQIS--------