>H_sapiens_ENSP00000360242 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLK---------TFANFPSGSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY-KV----- ---------------ENYLGSRDHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MYSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GIGDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLN----------------------IRSES DAVSSDRNFPNST----------------------------------------------- --------------------------------------NLPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIFTF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-EECLVRTTEKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TRRIDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKIME------------------------------- ------------------------------------------------------EK--IQ ISGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------VADLVN--AQKDSMQD-ESSQTSL-- -QKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAIVFVP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >P_pygmaeus_ENSPPYP00000023167 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLK---------TFANFPSGSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY-KV----- ---------------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MYSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GIGDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLN----------------------IRSES DAVSSDRNFPNST----------------------------------------------- --------------------------------------NLPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIFTF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPTEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-EECLVRTTEKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TRRIDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKIME------------------------------- ------------------------------------------------------EK--IQ ISGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------IADLVN--AQKDSTQD-ESSQTSL-- -QKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAIVFVP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >P_troglodytes_ENSPTRP00000038304 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLK---------TFANFPSGSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY-KV----- ---------------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MYSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GIGDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLN----------------------IRSES DAVSSDRNFPNST----------------------------------------------- --------------------------------------NLPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIFTF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYISNIHLTHSL-EECLVRTTEKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TRRIDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKIME------------------------------- ------------------------------------------------------EK--IQ ISGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RLEVL----------------VADLVN--AQIKGMQD-ESSQTS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAIVFVP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >O_cuniculus_ENSOCUP00000008505 ----------------------------------MTFNSFEGSKTCVPADINKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFENSAAQSTNPGVQNGQY-KG----- ---------------ENYLGNRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MCSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GIDDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVN----------------------IRSES DVVSSDRNFPNST----------------------------------------------- --------------------------------------NPPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIISF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPNEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-EESLARTAENTPSQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKRIDDTIF QSPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFREIKKIME------------------------------- ------------------------------------------------------EK--VQ MCGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------VADLVN--AQKSSTQD-ESSQTSL-- -QKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >E_caballus_ENSECAP00000017630 ----------------------------------MTFNSFEGSKTCVPADIDKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVQC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFENNAAQPTNPGVQNGQY-KV----- ---------------ENYLGNRNHF-VLGRPSETHAEYLLRTGQVVDISDT--IYPRNPA MCSEEARLKSFQN-------WPDYA--HLTPGELASAGLY---YT----GIDDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVN----------------------IRSES DVVSSDRNFSNST----------------------------------------------- --------------------------------------NLPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIITF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYISNIHLTCSL-EESLVRTAEKT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TERIDDTIF RNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFRDIKKIME------------------------------- ------------------------------------------------------EK--IH TSGSNYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEIL----------------VADLVN--AQKDNTQD-ESSQTSL-- -QQE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISA--EEQ----- ------------------------------------------------------------ -------------------LRLLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCNTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >R_norvegicus_ENSRNOP00000009358 ----------------------------------MTFNSFEGSRTVVPADTNKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVQC FSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQY-KS----- ---------------ENCVGNRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MCSEEARLKTFQN-------WPDYA--HLSPRELASAGLY---YT----GIDDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVN----------------------VRSES G-VSSDRNFPNST----------------------------------------------- --------------------------------------NSPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AEYDA RIVTF------------------------------------------------------- ---------------------------G---TW---LYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLDE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-GESVVRTAEKTPSV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKKIDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFNFKDIKKTME------------------------------- ------------------------------------------------------EK--LQ TSGSNYL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------IADLVS--AQKDNSQD-ESSQTSL-- -QKD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAIVFVP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCCTVITF---KQFLCL-------- -----NPAPQ-------------------------------------------------- ----------- >M_musculus_ENSMUSP00000110746 ----------------------------------MTFNSFEGTRTFVLADTNKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVQC FSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFENGAAQSTNPGIQNGQY-KS----- ---------------ENCVGNRNPF-APDRPPETHADYLLRTGQVVDISDT--IYPRNPA MCSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GADDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVN----------------------VRSES G-VSSDRNFPNST----------------------------------------------- --------------------------------------NSPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AEYEA RIVTF------------------------------------------------------- ---------------------------G---TW---TSSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLDE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-EESLGRTAEKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKKIDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKTME------------------------------- ------------------------------------------------------EK--IQ TSGSSYL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------IADLVS--AQKDNTED-ESSQTSL-- -QKD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAIVFVP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >B_taurus_ENSBTAP00000053449 ----------------------------------MTFNSFEGSKTCVPADIDKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAIGRHRRVSPNCRFINGFYFENNAAQPTYSGVQNGQY-KA----- ---------------ENYLGNRNHF-VLERPSETHAHYLLRTGQVVDLSDT--VYPRNPV MCSEEARLKSFHN-------WPDYA--HLTPRELARAGLY---YT----GIDDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNIN----------------------MQSES SVVSSDRNFPNST----------------------------------------------- --------------------------------------NAPI---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIITF------------------------------------------------------- ---------------------------G---TW---MYSVNKEQLARAGFYA-LGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLND------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EEYVNNIHLTHSI-EESLVSHILNTPSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------IFISDDTIF QNPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKTME------------------------------- ------------------------------------------------------GK--IQ TSGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEVL----------------VADLVN--AQKDNTQD-ESSQTSL-- -QKD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRLLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTAITL---RQKIFM-------- ---------S-------------------------------------------------- ----------- >C_familiaris_ENSCAFP00000034255 ----------------------------------MTFNSFEGAKTCVPAGINKDEEFVEE FNRLK---------TFANFPSSSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHASIDRWQYGDSAVGRHRKVSPNCRFINGFYFENTAAQPTNPGIQNGQY-NA----- ---------------ENYLRNRDHF-VLDRPSETHADYLLRTGQVVDISDT--TYPENPA MYSEEARLNSFQN-------WPDYV--HLTPRELASAGFY---YT----GIDDQVQCFCC GGKLKNWEPCDNAWSEHRRHFPNCFFVLGRNVN----------------------IRSES DVASTDRNVPNST----------------------------------------------- --------------------------------------SIPE---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIVTF------------------------------------------------------- ---------------------------R---MW---MCSINKEQLARAGFYS-LGDGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPSEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSVVSHILLRTAERTRSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TERIEDAIF QNPML---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFSFKDIKKIME------------------------------- ------------------------------------------------------EK--IQ TSGSNYV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLEAL----------------VSDLVS--AQKDHTQD-ESSQTSL-- -QKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISA--EEQ----- ------------------------------------------------------------ -------------------LRLLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RNIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDKCPMCYTVITF---KQKIFM-------- ---------S-------------------------------------------------- ----------- >M_domestica_ENSMODP00000018715 ----------------------------------MTFKSFEDSKTCVPPDINKDEDFVEE FNRLK---------TFANFPSSSPIS-ASTLARAGFL-------------YTGEGDTVKC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYFEKNATRFPNPIIQNCQY-RV----- ---------------ENCSRNRNHF-ALERPSETHGEYLLRTGQVIDMSDT--IYPRNPS MCSEEARLRSFQN-------WPDYA--HLTPQELASAGLY---YM----GFEDQVQCFCC GGKLKNWEPCDRAMSEHKRHFPKCFFVLGRDVGN---------------------TRIET D-VSCDRSCPNPT----------------------------------------------- --------------------------------------HLPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RLITF------------------------------------------------------- ---------------------------A---TW---IYSVNKEQLAKAGFYA-LGDHD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVLCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPNEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYVSSIHLVHPF-NSSMVKSRKMASSV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TQEIDDSVL QNPLV---Q--------------------------------------------------- ------------------------------------------------------------ ------------DAIRMGFNFLEIKKIMR------------------------------- ------------------------------------------------------EK--IQ SSGNNYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SLELL----------------VADLVS--AQKESSQDGESSPTLS-- -EKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------ENIAVVFIP-----------------CGHLV----- -SCQLC------------------------------------------------------ ---------------------------AEAIDKCPMCYTVITF---KQKIFI-------- ----RKPSPN-------------------------------------------------- ----------- >G_gorilla_ENSGGOP00000008442 ----------------------------------MTFNSFEGSKTCVPADINKEEEFVEE FNRLK---------TFANFPSGSPVS-ASTLARAGFL-------------YTGEGDTVRC FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY-KV----- ---------------ENYLGSRNHF-ALDRPSETHADYLLRTGQVVDISDT--IYPRNPA MYSEEARLKSFQN-------WPDYA--HLTPRELASAGLY---YT----GIGDQVQCFCC GGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLN----------------------IRSES DAVSSDRNFPNST----------------------------------------------- --------------------------------------NLPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYEA RIFTF------------------------------------------------------- ---------------------------G---TW---IYSVNKEQLARAGFYA-LGEGX-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPXEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYINNIHLTHSL-EECL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_anatinus_ENSOANP00000006435 ----------------------------------MTCNSPEELRTSNPSEVNKDEEFAEE HNRLR---------TFANFPSTSPVS-SSTLARAGFL-------------YTGEEDVVRC FSCHVAVDRWQYGDSAIGRHRKISPNCRFVNGCHFKNCALPLANASLQNGELGQV----- ---------------EECPGNPSHH-ALERSSETHSDYLLRTRQVVDLSDT--VFPKNPA MCSEEARLETFQN-------WPEYT--LLSPGQLARAGLY---YS----GIDDQVECFCC GGKLKNWEPCDRPWSEHKRHFPKCLFVLGRDVGN---------------------IEIES DSIASQRSYSNST----------------------------------------------- --------------------------------------HFPR---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AEFEA RIHTF------------------------------------------------------- ---------------------------E---TW---TYSIDKELLARAGFYT-LGEQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVICFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLTD------------------- ------------------------------------------------------------ -----------------------------------------------------WKPNEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---KYLVEQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFINNVHLTQSL-EDSVLEADETPPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKAITIIVF QNLVVGQLA--------------------------------------------------- ------------------------------------------------------------ ------------EARAMLYKFYHAHTSIC------------------------------- ------------------------------------------------------KV--VT IRKLVYS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PLEML----------------TKSVSK--GREANSNP-KSTHYFLFF PSVE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISP--EEE----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------KNIAVVFLP-----------------CGHLV----- -ACKEC------------------------------------------------------ ---------------------------GEAMGKCPVCCTLINY---RQKIFM-------- ---------S-------------------------------------------------- ----------- >G_gallus_ENSGALP00000038337 ----------------------------------MTCNGPDSSESGATPATDGDQEWTQE HYRLG---------TFVEFPHDCPVS-ASALARAGFV-------------YTGEGDKVKC FSCHVTVEGWEPGDSAIDRHKNLSPDCRFITGSAFLENNVHPLVQSHQHRT--------- ---------------ENGSSNLALPSALEDLSDVEADYLLRTRQVVDMSDT--LYPKNPA MCSEEARLKSFHN-------WPPYG--LLTPKELASAGLY---YT----GVGDQVACFCC GGKLKNWEPGDRAWSEHKRHFPKCFFVLGRDVGN---------------------VSTDS ICAELGRSCLNNE----------------------------------------------- --------------------------------------QHPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AEYER RIQTF------------------------------------------------------- ---------------------------L---AW---IYPVNKEHLAEAGFYS-TGNGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HVVCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLQE------------------- ------------------------------------------------------------ -----------------------------------------------------WKENEDP WDQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---KFLRDE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LEFINNVHLRDGC-RDSTIEAAEVTILP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KDDLL QNQLV---Q--------------------------------------------------- ------------------------------------------------------------ ------------NAIHMGFSLSEIRSIME------------------------------- ------------------------------------------------------KK--LH LSGESYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVEDL----------------VADLIS--AQKENIKGEPPKESPL-- -EQD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LSI--EEK----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMA------------------------- ------------------------KDISVVLIP-----------------CGHLV----- -ACKEC------------------------------------------------------ ---------------------------AEAVNKCPLCCTNIIK---RQKIFM-------- ---------Y-------------------------------------------------- ----------- >T_guttata_ENSTGUP00000003825 ------------------------------------------------ADTDGAREWAQE RERQG---------TFVGFPQGCPVS-VLALAQAGFV-------------YTGEGDKVKC FSCNTTIEGWVPGDSALERHKKLAPTCKFITESAFLKSDMDPVAQNYQNRT--------- ---------------ENGTSNSALP-CALDDPDVEADYLLRTRQVVDMSDS--LYPKNPA MCSEETRLKSFHN-------WPLND--RLTPQELANAGFY---YT----GVGDQVACFCC GGKLKNWEPSDRAWSEHKRHFPKCLFVQGRDIGN---------------------VSSES IPSELGISGLNNA----------------------------------------------- --------------------------------------QHPR---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TKYGK RLQTF------------------------------------------------------- ---------------------------L---SW---IYPVAKERLAEAGFYS-VGNGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HVVCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLQE------------------- ------------------------------------------------------------ -----------------------------------------------------WKENEDP WDQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---RFVSNE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IEFINNVHLKDGC-RDSTVSVLLINHFV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EIAKINIVLY ENPWV---Q--------------------------------------------------- ------------------------------------------------------------ ------------SAIAMGFSLSEIRNTME------------------------------- ------------------------------------------------------KR--LQ MTGESHT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVEDL----------------VADLS---AHTENTREEEPNEIPV-- -EQDEL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHT--EEK----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMA------------------------- ------------------------KDVSVVFIP-----------------CGHLV----- -ACKEC------------------------------------------------------ ---------------------------AQLLNECPLCRSDIMK---IQEIFM-------- ---------Y-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000035327 ---------------------------LAEFVLKEEMTCQCPKMSDGAYDMDVDQNYFEE EVRLA---------SFANFPSSYPVS-APALARAGFY-------------YTGDGDRVKC FSCLAMVEGWQHGDTAIGKHRKISPNCKFINGFNNLRSDCILTQVPVM------------ --------------QNGFQNSAEDL-AERSSSEIMADYLLRTGRVVDMSTP--KYPRHME MCSEEARLQTFQN-------WPAYS--PLTPKELANAGLF---YT----GINDQVKCFCC GGKLMNWEPSDKAWTEHKKHFPECYFVLGRDVGN---------------------VATEA NTHGGRRRG--------------------------------------------------- --------------------------------------SELA---CPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NDYNA RLETF------------------------------------------------------- ---------------------------S---SW---SFPIDKETLAKAGFYS-IGDGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ATKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGVLNC------------------- ------------------------------------------------------------ -----------------------------------------------------WSATDDP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KA---------------------- -----------YP--GC---KFLIDE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QHFINHAQLKRPI-LHKANSADASPALP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------KDSNLL KSPLV---T--------------------------------------------------- ------------------------------------------------------------ ------------NAQQMGFPLEEIKKVMG------------------------------- ------------------------------------------------------QK--LK TTGKNYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CVEEF----------------VSDLC---AQKETVLEKPKEIE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISL--EEK----- ------------------------------------------------------------ -------------------LRQLE------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------IC-------------------------------- ------------------------------KVCMD------------------------- ------------------------RRISIVFIP-----------------CGHLV----- -ACAVC------------------------------------------------------ ---------------------------ADVLDKCPICCTIVER---RQKIFM-------- ---------S-------------------------------------------------- ----------- >H_sapiens_ENSP00000321377 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TGYEA RLITF------------------------------------------------------- ---------------------------G---TW---MYSVNKEQLARAGFYA-IGQED-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLAN------------------- ------------------------------------------------------------ -----------------------------------------------------WKPKEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HEYINNIHLTRSL-EGALVQTTKKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKRISDTIF PNPML---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFDFKDVKKIME------------------------------- ------------------------------------------------------ER--IQ TSGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLEVL----------------VADLVS--AQKDTTEN-ELNQTSL-- -QRE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISP--EEP----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RHIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDRCPMCSAVIDF---KQRVFM-------- ---------S-------------------------------------------------- ----------- >P_troglodytes_ENSPTRP00000019640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TGYEA RLITF------------------------------------------------------- ---------------------------G---TW---MYFVNKEQLARAGFYA-IGQED-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLAN------------------- ------------------------------------------------------------ -----------------------------------------------------WKPKEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KYLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HEYINNIHLTRSL-EGALVQTTKKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKRINDTIF PNPML---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFDFKDVKKIME------------------------------- ------------------------------------------------------ER--IQ TSGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLEVL----------------VADLVS--AQKDTTEN-ESNQTSL-- -QRE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISP--EEP----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------DE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RHIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDRCPMCSAVIDF---KQRVFM-------- ---------S-------------------------------------------------- ----------- >A_carolinensis_ENSACAP00000011315 -----------------------------------------------------------E LSRQQ---------TFASFPSDCPVS-SAALAQAGFF-------------YTGERDQVKC FSCHTMVEGWQEGDSAIERHRTIFPECRFINDIDIGRNNTYSLLNCQHASEN-------- ---------------GSASTSQQQP-SLDESSDLDADYLLRTGQVVDLSGS--LYPRNPA MCSEEARLRTFHN-------WPPYA--PVTPQDLAHAGLY---YT----GIGDQVECFCC GGKLKNWEPSDQAWSEHRRHFPRCFFVLGHDLNR-------------------------- ---------SNNV----------------------------------------------- --------------------------------------VLPQ---NPCM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ADYET RLKTF------------------------------------------------------- ---------------------------V---AW---HYLVSKEQLARAGFYS-IGNGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SVACFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLQE------------------- ------------------------------------------------------------ -----------------------------------------------------WKAYEDA WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---KYVLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDFVNRV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gorilla_ENSGGOP00000007398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TGYEA WLITF------------------------------------------------------- ---------------------------G---TW---MYSVNKEQLARAGFYA-IGQED-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KIQCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLAN------------------- ------------------------------------------------------------ -----------------------------------------------------WKPKEDP WXQXA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--GC---KXLLEE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HEYINNIHLTRSL-EGALVQTTKKTPSL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TKRISDTIF PNPML---Q--------------------------------------------------- ------------------------------------------------------------ ------------EAIRMGFDFKDIKKIME------------------------------- ------------------------------------------------------EK--IQ TSGSNYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLEVL----------------XADLVS--XQKDTTEN-ESNQTSL-- -QRE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISP--XEP----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RHIAVVFIP-----------------CGHLV----- -TCKQC------------------------------------------------------ ---------------------------AEAVDRCPMCNAVIDF---KQRVFM-------- ---------S-------------------------------------------------- ----------- >D_rerio_ENSDARP00000013586 -----------------------FPP--QRNLVTTNMA--HSTHNGELESDNVAADWSVM KNRVN---------SFQRFPYSEDIS-AQRLARAGFY-------------FTGEGDRVQC FSCSATVQNWNRGDTPLERHQLASPDCRFLSCAHGMRNS--------------------- ---------------NSI-----QS-PDYDEEAENREFLLRTGEVVDES----MYPVVPH MKSEEARLSTFNN-------WPADS--PVRPEDLAEAGMY---YI----GIDDNVQCFCC GGGLSGWEQGDDPWSEHAKYYSNCFFFLGHNVGN---------------------VPL-- ------T--------------------------TPRP----------------------- --------------------------------------RANV---H-PT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DTFEG RLDSF------------------------------------------------------- ---------------------------K---GR---QHPIDPERLARAGFYS-TGEQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVMCFRC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGVKA------------------- ------------------------------------------------------------ -----------------------------------------------------WMPDEDP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RH---------------------- -----------YP--GC---SFLLAE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EEYVSSVQLRYPK-RPTQNGFSSHESGSSAQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALIHGSS------------------------------- ------------------------------------------------------DM--FE KA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DDP--MTE----- ------------------------------------------------------------ -------------------LEKLQ------------------------------------ ----------------------------------------------------------RE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KVCMD------------------------- ------------------------SDISIVFIP-----------------CGHLV----- -TCQKC------------------------------------------------------ ---------------------------SASLDKCPICCATITQ---KIKTYN-------- ---------A-------------------------------------------------- ----------- >G_aculeatus_ENSGACP00000024474 -----------------------VPP--SSILSSSIMC--ALRQDNQLESDH-MADFSEI NNRLD---------SFRGSSLAQQVP-AERLARAGFY-------------YTGNADRVCC FSCEKTVENWCRGDTPLERHKEVSPSCIFLSCTQRTNFN--------------------- ---------------LSCENRLTNG-FSYNEEEEDLEYRLRRGEVVDES----TYPMAPH MKSEEARLQTLST-------WPSSS--PVRPRDLAQAGLY---YL----GQSDRVQCFCC GGMLAGWEVGDTAWEEHNKHFPNCFFMLGHDVGN---------------------IPLHR GGVEEEN--------------------------SGRQ----------------------- --------------------------------------HASA---CVPM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSFEK RLGSF------------------------------------------------------- ---------------------------A---GV---LHPIDHERLARAGFYS-AGTGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVLCFRC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLKG------------------- ------------------------------------------------------------ -----------------------------------------------------WQPEEDP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KH---------------------- -----------YP--GC---SFLLTE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYVNSIQLQDPR-RNRTNGFSGHGNGKKGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AVGHGSE------------------------------- ------------------------------------------------------GR--WD DV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------DP--LEK----- ------------------------------------------------------------ -------------------LRELQ------------------------------------ ----------------------------------------------------------RE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------RDIGIVFIP-----------------CGHLV----- -TCTKC------------------------------------------------------ ---------------------------SESLIKCPICCGAITQ---KIQTYI-------- ---------A-------------------------------------------------- ----------- >O_anatinus_ENSOANP00000016616 -----VHKTTSRGETRPVSPATPTEYFVMNVVAN-SMFLSNLMNGNS-GYEL-KYDFSCE LFRMS---------TYSTFPTNVPVS-ERSLARAGFY-------------YTGASDKVKC FSCGLMLDNWKPGDSAIEKHKQLYPSCSFIQNLLQT--HNPGASSYSAFCPPPLGS---- --------LSPTAT-ISPSLEPSGY-FSGSFSS-FPLDPVTSRAIEDLSQPR-PHVDNSA MSSEEARICTFQS-------WPLT---FLSPSALAKAGFY---YT----GPGDRVACFTC GGKLSNWEPKDDAMSEHRRHFPGCPFLERQTRDA---------------------SR--- ------------------------------------------------------------ --------------------------------------FNVS---NASM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RVKTF------------------------------------------------------- ---------------------------L---NWPA-RIPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WIEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYMIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVNQIQARYPH-LLEQ--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VDESADPP--IIHFGPGENPAED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M SNPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRRLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDL----------------VSDLLN--AEDETR----EEEKER-- -QNEEMAS--DDLSLIRKNR---MALFQHLTC-VLPI----------------------- -----------------------LDSLLSAGVISEQERDVIKQKTQTSLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNCLKEDDCILYKNLFVEKNMKYIPTEDV--SG--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >T_guttata_ENSTGUP00000013125 ----------------------------LNTVED-SPFLTSIMRQSALCDEL-KYDLSCE LYRMS---------TFSTFPMNTPVS-ERSLARAGFY-------------YTGVQDKVKC FSCGLTLDNWQPGDNAMEKHKQLYPRCSFVQRMLSD--NNVGLSSRSAFSPSIANS---- -----LPPSLHSIA-LSPSLEQVGY-FSGSFSS-FPQDPVTTRAAEDLSFLS-PKLHNNS MRTEDARLCTFQS-------WPLT---FLSPTDLAKAGFY---YL----GTADKVACFTC GGQLYNWEPKDNAVSEHRRHYPNCPFVENLIRDQ---------------------QS--- ------------------------------------------------------------ --------------------------------------FNVS---NVSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHEA RVKTF------------------------------------------------------- ---------------------------L---NWPT-RIPVQPEQLADAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WIEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLRV-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ REFVDQIQARFPH-LLEQ--LLSTSDPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VNENLDPP--IIHFEPGESHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRRLIKQTVQ------------------------------- ------------------------------------------------------SK--IL VTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDL----------------VSDLLM--AEDETI----QEEKEK-- -QLEEVAS--DDLYLIQKNR---MALFQRLTC-VLPI----------------------- -----------------------LGSLLSAKVITELEHDVIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNEAASIFRNCLRDCDPVLYKDLFVEKTIKYVPTEDV--SG--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >G_gallus_ENSGALP00000035646 ----------------------------MNIMDS-SPLLASVMKQNAHCGEL-KYDLSCE LYRMS---------TFSTFPVNVPVS-ERRLARAGFY-------------YTGVQDKVKC FSCGLVLDNWQPGDNAMEKHKQVYPSCSFVQNMLSL--NNLGLSTHSAFSPLVASN---- -----LSPSLRSMT-LSPSFEQVGY-FSGSFSS-FPQDPVTTRAAEDLSHLR-SKLHNPS MSTEEARLRTFHA-------WPLM---FLSPAELAKAGLY---YL----GTADKVACFTC GGQLSNWEPKDNAMSEHRRHFPNCPFVENLMRDQ---------------------PS--- ------------------------------------------------------------ --------------------------------------FNVS---NVTM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHEA RVKTF------------------------------------------------------- ---------------------------I---NWPT-RIPVQPEQLADAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WIEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLRV-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GEFVSQVQARFPH-LLEQ--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VDENMD-P--IIHFEPGESPSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRRLIKQTVQ------------------------------- ------------------------------------------------------SK--IL ATEENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDL----------------VSDLLT--AEDEKR----EEEKER-- -QFEEVAS--DDLSLIRKNR---MALFQRLTS-VLPI----------------------- -----------------------LGSLLSAKVITELEHDVIKQKTQTPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAASIFRNCLKDCDPVLYKDLFVEKSMKYVPTEDV--SG--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >T_rubripes_ENSTRUP00000010298 -----------------------MNPFDNMQLKKEITMEDQQHDSGTLETDS-AEDFSLI TSRLE---------SFRGSNLVQLVP-AERLARAGFH-------------FIGPSDRVRC FSCHKTVENWCTGDRPVERHKEVSPFCKFLSCIYRTSSN--------------------- ---------------PIPGTSLTNG-SAYNEEAEDMEYRLRTGQVVDES----IYPVVPH MRSEESRLHTFST-------WPLTA--PVSPCDLAQAGLY---YL----GQCDQVQCFCC GGTLADWEIGDSAWAEHSKHFPFCFFILGHDVGN---------------------IPFQG SIEEEG---------------------------SGRL----------------------- --------------------------------------HTSA---AVHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GTFEE RLRSF------------------------------------------------------- ---------------------------A---GV---NHPLNIERLARAGFYS-NGTED-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MVLCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLKG------------------- ------------------------------------------------------------ -----------------------------------------------------WQPEEDP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RH---------------------- -----------YP--GC---RFLLAE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVNHIQLQMPR-QKKANGFSAATNGTDTQTI--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------IHFLRNAIGQALE------------------------------- ------------------------------------------------------SS--IR TVLIARH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TVNLLLVQKSSPRVTAAMNRQY---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DDP--LEK----- ------------------------------------------------------------ -------------------LQKLQ------------------------------------ ----------------------------------------------------------RE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICMD------------------------- ------------------------KDIDIVFIP-----------------CGHLV----- -TCNEC------------------------------------------------------ ---------------------------SVSLIKCPICCGDIRQ---KVKTYI-------- ---------T-------------------------------------------------- ----------- >A_carolinensis_ENSACAP00000012475 ----------------------------LIIMNTFDTFAAKLKNVPD-VGQL-KYDLSCE LFRMS---------TFSTFPLHVPVS-ERSLARAGFY-------------YTGVKDKVKC YSCGLMLDNWKKGDNPLDKHKQLYPSCSVVQNLTSL--NNLGSSFYSAFSPPSLSV---- -----GHSSSHSPQ-QTPNLDQVGY-FSGSFSS-VPQEL--PKLTEGISHVR-PKVANSA MSSEEARLLTFKT-------WPLT---FLSPSSLAKAGFY---YI----GPADKVACFVC GGHLGNWEPKDNAMSEHRRHFPTCPFVE-QTQSQ---------------------PG--- ------------------------------------------------------------ --------------------------------------FTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTYRA RVGTF------------------------------------------------------- ---------------------------E---NWPM-TVPVLPQRLADAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIHR-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVRCVQARFPH-LLEQ--LLSTSDIP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VDENTSPP--IIRFEPGENGSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EV--------I-M KTPVV---E--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFRRRLVKQIVQ------------------------------- ------------------------------------------------------SK--IL RTGESYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SINDL----------------VSDLIA--ADDEKR----DDEKEP-- -QMEESTS---DLSLIRKNR---VALFQRLTC-VLPI----------------------- -----------------------LECLLASKAISSLEYQVIKQKTQTPLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNKAANIFRNCIQESDPVLYQDLFVEKNMTYIPA-DV--SG--LSM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >P_troglodytes_ENSPTRP00000007250 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQPTFPSSVTNS---- -----------THS-LLPGTENSGY-FGGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA MNNENARLLTFQT-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFAC GGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFKTF------------------------------------------------------- ---------------------------F---NWPS-SVLVNPEQLASAGFYY-VGNSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFIRQVQASYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RDENTESS--IIHFEPGEDHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---N--------------------------------------------------- ------------------------------------------------------------ ------------AAVEMGFSRSLVKQTVQ------------------------------- ------------------------------------------------------RK--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LVNDL----------------VLDLLN--AEDEIR----EEERER-- -ATEEKES--NDLLLIRKNR---MALFQHLTC-VIPI----------------------- -----------------------LDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNIAATVFRNSLQEADAVLYEHLFVQQDIKYIPTEDV--SD--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRSTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_mulatta_ENSMMUP00000004536 ----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKM-KYDFSCE LYRMS---------TYSTFPTGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKLGDSPIEKHKQLYPSCSFIQNLVS---ATLGSTSKNT-SPMRNSF---- -----------AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDLSPSR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RMRTF------------------------------------------------------- ---------------------------M---YWPS-SVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQGRYPH-LLEQ--LLSTSDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENADPP--IIHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFSRDLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKER-- -QAEEMAS--DDLSLIRKNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >H_sapiens_ENSP00000227758 ----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKM-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKNT-SPMRNSF---- -----------AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RMRTF------------------------------------------------------- ---------------------------M---YWPS-SVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQGRYPH-LLEQ--LLSTSDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--IIHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFNRDLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKEK-- -QAEEMAS--DDLSLIRKNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSVVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >P_troglodytes_ENSPTRP00000007251 ----------MHKTASQRLFPGPSYQNIKSIMED-STILSDWTNSNK--QKM-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKNT-SPMRNSF---- -----------AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDISSSR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RMRTF------------------------------------------------------- ---------------------------M---YWPS-SVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQGRYPH-LLEQ--LLSTSDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--IIHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFNRDLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKEK-- -QAEEMAS--DDLSLIRKNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNSAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSVVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >D_rerio_ENSDARP00000065554 IYMRTHTQGMTIKPFSLLAIPFPISLSQMEILQN-SAFLRGLCRTSG-PADL-QYDNSSE LFRIS---------TYAKFPTTAAVT-ERSLARAGFY-------------YTGLGDRVQC FRCNVTADNWQSGDCPAERHKQLSPNCSFIQSLPAT--ANLLSSSHSAFSPLRNVAVLQL SAPATAAPSTTAPSTSGQTEEQVGY-LNMGFTNLAPSSPISSRGVEDMSHQRPPACHNPG MRREQERLDTFQN-------WTLA---TVTPAELAKAGLY---YL----GQGDRVACFSC GGQLGSWEPGDRAVSEHQRHYPNCRFVRGDRADNIPLSGG---------------GL--- ------------------------------------------------------------ --------------------------------------SNVS---NSAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQCEE RLLTF------------------------------------------------------- ---------------------------V---NWPS-RIPVRPDQLAKAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP-SRC---EYLLQE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVHQIQARFPR-LFEQ--LLTNGDSN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SREFVDPP--VVHLGPGEDRSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NNPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFERGLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TSGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVQEL----------------VSDLLS--AEDEKR----EEEREL-- -LAEEMAS--DGFTFLKKHH---AALSQRLKS-VQSL----------------------- -----------------------MDHLLEENVISQKEYDSIRNCTSVKQQTGQLIDLV-- ------------------------------------------------------------ ------------------------------------------------------------ -LSKGNAAAEVFRNWIKKNDVYLLRELMAQTNEAASPSQDL--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVNIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGMVKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >T_nigroviridis_ENSTNIP00000012883 --L----PALFEGLLPFILLCFDTKMETLVQLKN-NPFLMGLCRNCP-PPDL-QYDNSSE LYRIS---------TFARFP-SSGVT-ERSLARAGWF-------------YTGVGDRVQC FKCNVTAEGWQAGDCPTEKHRQLSPSCTFIQSLPST--SNLLSSSHSAFSPLRIAPAIPL SG---AGPAVPNPS-ANPGEEPVGY-LNMGFSAPPPSSPLGSRGVEDMSHQR-PTCHNPN MRREQDRLDSFHS-------WTLT---IITPAELAKAGFY---YL----SQGDRVACFSC GGQLNNWEPGDRAMSEHQRHYPNCRFVRGDRADNISLAGA-VPGGLTSQLSGGVPTL--- ------------------------------------------------------------ --------------------------------------SNVS---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQSEE RLLTF------------------------------------------------------- ---------------------------V---NWPS-RIPVRPDQLARAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLQE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDFVHQIQARFPR-LFEQQKLLTNGDTS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SREFVDPP--VVHLGPGEERSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFERSLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TSGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVQEL----------------VSDLLS--AEDQKR----EEEREM-- -LAEAMAS--DGFTFVKRHQ---AALIQRLKS-VEPV----------------------- -----------------------LEHLREQNVLSHEEYSGLKAQTSAQQQTARLIELI-- ------------------------------------------------------------ ------------------------------------------------------------ -LTKGNAAAEVFRNWIQKNDVHLLRDLMAQSSEASSPSQDL--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVNIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGLVKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >H_sapiens_ENSP00000376897 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSV--NNLEATSQPTFPSSVTNS---- -----------THS-LLPGTENSGY-FRGSYSN-SPSNPVNSRANQDFSALM-RSSYHCA MNNENARLLTFQT-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFAC GGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFKTF------------------------------------------------------- ---------------------------F---NWPS-SVLVNPEQLASAGFYY-VGNSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFIRQVQASYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENAESS--IIHFEPGEDHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVI---N--------------------------------------------------- ------------------------------------------------------------ ------------AAVEMGFSRSLVKQTVQ------------------------------- ------------------------------------------------------RK--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LVNDL----------------VLDLLN--AEDEIR----EEERER-- -ATEEKES--NDLLLIRKNR---MALFQHLTC-VIPI----------------------- -----------------------LDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDV--SD--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRSTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >P_pygmaeus_ENSPPYP00000004357 ----------MHKTASQRLFPGPSYQN-KSIMED-STILSDWTNSNK--QKM-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVS---ASLGSTSKNT-SPMRNSF---- -----------AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAVEDFSSSR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RMRTF------------------------------------------------------- ---------------------------M---YWPS-SVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQGRYPH-LLEQ--LLSTSDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--IIHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFNRDLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKEK-- -QAEEMAS--DDLSLIRKNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_mulatta_ENSMMUP00000004533 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMS---------TYSAFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKRGDSPVEKHKKLYPSCRFVQSLNSV--NNSEATSQPAFPSSVTNS---- -----------THS-LLPGTENSGY-FSGSYSS-FPSNPVNSRANQDFSALM-RSSYHCA MNNEKARLLTFQT-------WPLT---FLSPTDLAKAGFY---YV----GPGDRVACFAC GGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFKTF------------------------------------------------------- ---------------------------F---NWPS-SVLVNPEQLASAGFYY-VGNSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFIRQVQASYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENAESS--IIRFEPGEDHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---N--------------------------------------------------- ------------------------------------------------------------ ------------AAVEMGFSRSLVKYTVQ------------------------------- ------------------------------------------------------RK--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LISDL----------------VLDLLN--AEDEMR----EEERER-- -ATEEKES--NDLLLIRKNR---MALFQHLTC-VIPI----------------------- -----------------------LDSLLTARIINEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNIAATVFRNSLQEADAVLYERLFVQQDIKYIPTEDV--SD--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRSTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >T_rubripes_ENSTRUP00000043752 --LLSPDPPLGGPTFTLILLCFHTKMETLVQLKN-NPFLMGLCRNCP-PPDL-QYDNSSE LYRIS---------TFARFP-TSGVT-ERSLARAGWF-------------YTGVGDRVQC FKCNVTAEGWQAGDCPTEKHRQLSPSCSFIQSLPST--SNLLSSSHSAFSPLRIAPAIPL SG---AGPAVPNPS-ANQGEEPVGY-LNMGFSAPPPSSPLISRGVEDMSHQR-PTCHNPN MRREQDRLESFHS-------WTLT---IITPAELAKAGFY---YL----SQGDRVACFSC GGQLSNWEPGDRAMSEHQRHYPNCRFVRGDRADNISLAGA-APGGL-------------- ------------------------------------------------------------ --------------------------------------TNVS---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQSEE RLLTF------------------------------------------------------- ---------------------------V---NWPS-RIPVRPDQLAKAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLQE-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDFVHQIQARFPR-LFEQ--LLTNGDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SREFVDPP--VVHLGPGEERSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFERSLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TSGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVQEL----------------VSDLLS--AEDQKR----EEEKEM-- -LAEAMASALDGFTFVKRHQ---AALIQRLKS-VEPV----------------------- -----------------------LEHLREQNVLSHEEYSGLKAQTSAQQQTARLIELV-- ------------------------------------------------------------ ------------------------------------------------------------ -LTKGNAAAEVFRNWIQKNDVHLLRDLMAQSSEASSPSQDL--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVNIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGLVKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_musculus_ENSMUSP00000091422 ----------MDKTVSQRLGQGTLHQKLKRIMEK-STILSNWTKESE--EKM-KFDFSCE LYRMS---------TYSAFPRGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQTLLS---ASLQSPSKNM-SPVKSRF---- -----------AHS---SPLER-----GGIHSN-LCSSPLNSRAVEDFS-SR-MDPCSYA MSTEEARFLTYSM-------WPLS---FLSPAELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPHCPFLENTS-ET---------------------QR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHSA RLRTF------------------------------------------------------- ---------------------------L---YWPP-SVPVQPEQLASAGFYY-VDRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WIEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQARYPH-LLEQ--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPTETVVHFGPGES-SED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VV--------M-M STPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVRQTVQ------------------------------- ------------------------------------------------------RQ--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSVLLN--AEDERR----EEEKER-- -QTEEMAS--GDLSLIRKNR---MALFQQLTH-VLPI----------------------- -----------------------LDNLLEASVITKQEHDIIRQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNSLKEIDSTLYENLFVEKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------REVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000048002 --------------------------MANEILDR-RPDLAKRLKSNPSMCKI-TLEFSCE LYRLS---------TFSTFPSNTHVS-ERNLAKAGFY-------------YTGQDDKVKC FTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV---NLGASLYSAFSPPASNS---- -----TP----MHA-ASAENDKVEA-ITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY--- MYTEEARLNSFQE-------WSNM---FLTPAELAKAGFY---FV----GPGDKVACFTC DGKLNNWEPNDNAMSEHRRHFPNCPFVKSSTRVS---------------------SR--- ------------------------------------------------------------ --------------------------------------FSVS---NVSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QASSA RLKTF------------------------------------------------------- ---------------------------A---SWPP-RIPISPTRLAEAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLHI-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDYVQEVQERYPH-LLDQ--LLSSSENQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------NEAKNIP--IIRLG-TENSQED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EI--------M-M STPMV---Q--------------------------------------------------- ------------------------------------------------------------ ------------TALEIGFNRRLVKRTIQ------------------------------- ------------------------------------------------------SK--ML TSGENYS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------QLDDL----------------ISDLLI--AQEEQT----EEERNR-- -QAEENSL--DDISVIRKSR---MALSQHIASRSIPI----------------------- -----------------------LDYLLSSNDITAAEYEAIKLKTQPILQAQEMIETI-- ------------------------------------------------------------ ------------------------------------------------------------ -ITKGKTAVQTLKNCLQKHDPNLFRQLFTEQSLKCISLDDY--SD--LSM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KICMD------------------------- ------------------------QEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >P_pygmaeus_ENSPPYP00000004355 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQPTFPSSVTNS---- -----------THS-LLPGTENSGY-FSGSYSS-FPSNPVNSRVNQDFSALM-RSSYHCA MNNENARLLTFQT-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFAC GGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFKTF------------------------------------------------------- ---------------------------F---NWPS-SVLVNPEQLASAGFYY-VGNSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFIRQVQASYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENAESS--IIRFEPGEDHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---N--------------------------------------------------- ------------------------------------------------------------ ------------AAVEMGFSRSLVKQTVQ------------------------------- ------------------------------------------------------RK--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LVNDL----------------VLDLLN--AEDEIR----EEERER-- -ATEEKES--NDLLLIRKNR---MALFQHLTC-VIPI----------------------- -----------------------LDSLLTARIINEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNIAATVFRNSLQEADAVLYEHLFVQQDIKYIPTEDV--SD--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRSTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >E_caballus_ENSECAP00000010270 ----------------------------MNIVEN-SVFLSNLMKSAN-MFEL-KYDFSCE LYRIS---------TYSTFPPGVPVS-ERSLARAGFY-------------YTGINDRVKC FCCGLMLDNWKQGDNPTEKHKKLYPSCSFVQNLNSV--NISGATSQLAFSSSVTNS---- -----------THS-LLPSLENSGY-FSGSYSS-FPSNPVNSGPNHDFSALR-TSPYHCA MNTEKARLLTFQM-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHLRHFPNCPFVENQFEDT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFRTF------------------------------------------------------- ---------------------------C---NWPS-SVQVPPEQLASAGFYY-MGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFISRVQANYPH-LLEQ--LLSTSDNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENAESP--IIHFGPGENHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRRLIKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TISDL----------------VLELLN--AEDEMR----EEEKER-- -ATEEKES--GDLSLIRKNR---MALFRHLTC-VLPI----------------------- -----------------------LDSLLTARVINEQEYDVIKQKTQTSLQSRELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNFAATIFKNSLQEIEPTLYKHLFVQQDIKYIPTEDV--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >R_norvegicus_ENSRNOP00000014560 ------------------------------IMEN-STVLSNWTKENK--EKM-KYDFSCE LYRMS---------TYSAFPRGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLS---GGLQSAAKNT-SPAKSRF---- -----------AHS---LPLEQ-----GGIHSS-LPSNPLNSRAVEDFS-LR-MNPCSYA MSTEEARFLSYSM-------WPLS---FLSPAELAKAGFY---YT----GPGDRVACFAC GGKLSNWEPNDDPLSEHRRHFPHCPFLENTS-ET---------------------QR--- ------------------------------------------------------------ --------------------------------------FSVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHSA RMRTF------------------------------------------------------- ---------------------------L---YWPS-SVLVQPEQLASAGFYY-VDHND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WIEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQARYPH-LLEQ--LLSTSDTS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EEENADPPERVVHLGPGEN-WED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALDMGFSRSLVRQTVQ------------------------------- ------------------------------------------------------RQ--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVSDI----------------VSALLN--AEDERR----EEEKER-- -QSEETAS--GDLSLIRKNR---MALFQQLTC-VIPI----------------------- -----------------------LDDLLEASVLTKEEHDIIRQKTQIPLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAASVFKNSLKEVDSTLYEHLFVEKTMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------REVSIVFIP-----------------CGHLV----- -VCREC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >C_familiaris_ENSCAFP00000022277 ----------MHKTTSQRLVPG-SYQRIKRTMED-STILRNQTIGNK--QKI-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKPGDNPVEKHKQLYPSCSFIHSLVSL--TSRDSTSKNI-SAMRNSF---- -----------THS-ISPTLEH-GS-FSGSHSN-LAANPVSSRAGEDFSPLS-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSDLARAGFY---YI----GPGDKVACFAC GGTLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RLRTF------------------------------------------------------- ---------------------------V---YWPS-SVPVRPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQARYPH-LLEQ--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENADPPNSFVHFGPGENHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRILVRQTVQ------------------------------- ------------------------------------------------------SK--IL STGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNEI----------------VLALLN--AEDETR----EEEKER-- -QTEEMAS--DDLSLIRRNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNSAANIFKSCLKEIDSTLYKNLFVDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >E_caballus_ENSECAP00000000598 -------------------------------MED-STILSSWTVGNK--QKM-KYDFSCE LYRMS---------TYSTFPTGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVSV--TSLESTSKNTSSPMRNSF---- -----------THS-LSPTLEHSGS-FSGSYSN-LSPNLVNSRAVEDFSPLR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGTLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RLRTF------------------------------------------------------- ---------------------------M---YWPP-RVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLISM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQARYPH-LLEQ--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENADPP--IVHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKER-- -QTEEMAS--DDLSLIRRNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAANIFKNCLKEIDSTLYENLFVEKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APALRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_domestica_ENSMODP00000000728 -----THKTTSQRKT---CPLLFPKYSIMSVVED-GVLLSHLMSSDT--HEM-KYDLSCE LYRMS---------TYSAFPVNVPIS-ERSLARAGFY-------------YTGVNDRVKC FCCGLMLDNWKQGDNAIDKHKQLYPSCAFIQNLISV--N--LGSSQSTFSSSVNNA---- -----------TRS-LSLSSEQSGY-FSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS MSTEEARILTYQA-------WPLT---FLSPLDLARAGFY---YI----GPGDMVACFAC GGKLSNWEPKDDAMSEHRRHFPHCPFLESQIQET---------------------SR--- ------------------------------------------------------------ --------------------------------------FNVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RVKTF------------------------------------------------------- ---------------------------V---TWPP-QIPVHPEQLANAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--R----QYLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDQVQARYPH-LLEQ--LLSTSDIP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENAELP--IIHFGPGENNSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVKQIVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNEV----------------VSDLLN--AEDEKR----KEEKER-- -QTEEMAS--DDLTLIRKNR---MALFQHLTC-VLPI----------------------- -----------------------LDSLLTSGVINEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNAAASVFKNCLREIGSVLYNNLFVEKNMKYIPTEDV--SG--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >T_nigroviridis_ENSTNIP00000018867 -------------------------------------MEDQRHDNSNLETDS-AEDFSLI KSRLE---------SFRGSSLVQRVP-AERLARAGFY-------------LVGPSDRVRC FSCQKTVENWSREDRPVERHKEVSPVCQFLSCIYGTRPH--------------------- ---------------QLIDASLANN-SAYNEE-----------AVVDES----IYPVAPH MKSEKSRLQTFSS-------WPSAV--PVRPQDLAQAGLY---YL----GQNDQVQCFCC GGILANWDAGDSAWGEHNKHFPSCFFILGHDVGN---------------------IPLQG SGEEEKRV-------------------------VPPA----------------------- --------------------------------------GAGA---GVHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GTFEE RLRSF------------------------------------------------------- ---------------------------A---NV---QHPVNTERLARAGFYS-KGT-D-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AVLCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLKG------------------- ------------------------------------------------------------ -----------------------------------------------------WRPEEDP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RH---------------------- -----------YP--GC---RFLLTE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVNSIQLRVSG-RNTA----VSQAVQDIQVFK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIATVHFRVQVIRMDFQ------------------------------- ------------------------------------------------------QQQWVH THTKVHT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DSSRQFFFKCETAAGQQNNRIFDI-- -GVCPSCPPE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DDP--KKL----- ------------------------------------------------------------ -------------------LQKLQ------------------------------------ ----------------------------------------------------------CE K----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KICLA------------------------- ------------------------KDICIVFIP-----------------CGHLI----- -ACEEC------------------------------------------------------ ---------------------------SESLVSCPVCCGGITQ---KVKTFL-------- ---------TYPAKQ--------------------------------------------- ----------- >C_familiaris_ENSCAFP00000022282 ----------------------------MNIVQN-SIFLSNLLRSSP-VFEL-KYDHSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGAKDRVRC FCCGLMLDNWKAGDSPTGKHRNLYPSCSFIQNLSAV--STVGAASQPPAPLSEARS---- -----------THA-QSPGLERSSY-FSASYSS-FPVDPVDFRPSPAMSPWR-AGPSCVT MKSEEDRLCTFQG-------WPLA---FPLPSALARAGFY---YV----GPGDRVACFAC GGKLSNWEPDDDALSEHLRHFPDCPFVEGQLQAT---------------------VR--- ------------------------------------------------------------ --------------------------------------YTAS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTLAA RSRTF------------------------------------------------------- ---------------------------C---NWPP-RAPVHPEQLASAGFYY-MGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFISQIQASYPH-LLEQ--LLSTSDNT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENTESP--IVHFGPGEYHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---M--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVRQTVQ------------------------------- ------------------------------------------------------SK--IL STGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNEI----------------VSDLLH--VEDEIR----EEEKER-- -AAENRES--DDVSLIRKNK---MVLFQHLTY-VLPI----------------------- -----------------------LDSLLMAGVLNEQEHSSIKQKARTSLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGSSAVTIFKNSLQEIDPMLYKRFFVQQDRKYIPTEDI--SD--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCRDC------------------------------------------------------ ---------------------------APSLRKCPICRGTVRG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >R_norvegicus_ENSRNOP00000007702 ----------------------------MNMVQG-SAFLAKLMKSAD-TFEL-KYDFSCE LYRLS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FSCGLMLDNWKQGDSPIEKHRKLYPSCSFVQTLNPA--NSLEASPQPPLPSTATST---- -----------MPS-GFAASESTGY-FSGSYSS-FPSDPVNFRANQDCPAFS-TSPYHFA MNTEKARLLTYQT-------WPLS---FLSPAELAKAGFY---YT----GPGDRVACFAC GGKLSNWDRKDDPLSEHRRHFPSCPFLKDVGQFT---------------------SQ--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RVRTF------------------------------------------------------- ---------------------------S---TWPS-SALVHPQELASAGFYY-TGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVGQVQAGYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDETGEAA--IVHLGPGEN-WED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALDMGFSRSLVRQTVQ------------------------------- ------------------------------------------------------RQ--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVSDL----------------VIGLLD--AEDEMR----EEQTEQ-- -EAEEEES--DDLTLIRKNK---MVLLQHLTP-VTPI----------------------- -----------------------LDCLLSARVITEQEYDAVKQKPHT-LQARTLIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LAKGNTAATSFRNSLQEIDPGLYRDIFVRQNIRSLPTDDI--AA--LPM--EEQ----- ------------------------------------------------------------ -------------------LRKLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------REVSLVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >O_latipes_ENSORLP00000006992 ----------------------------LVQLKN-SKFLMGLCRNGP-PSDL-QYDNSSE LFRFS---------TFARFP-TSVVT-ERSLARAGWF-------------YTGVGDRVQC FRCNVTAEGWLAGDCPTEKHRQLSPTCPFIQSLPST--TNLLSSSHSAFSPLRIAQAMPV SSERRQGPAASNPS-GGQSEEAVGY-LNMAFSAPPPSSPLASRGVEDLSHQR-PTCHNPS MRREQDRLDSFQP-------WAIS---IITPAELAKAGFY---YL----GQNDRVACFSC GGQLSNWEPGDRAVSEHQRHYPNCRFVRGDRADNVPLVAG--ATALSAAASSGALAL--- ------------------------------------------------------------ --------------------------------------TSVS---NPSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQSED RRLTF------------------------------------------------------- ---------------------------V---NWPS-RIPVRPEQLAKAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLQE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDFVHQIQARFPR-LFEQ--LLTNGENS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SREFVDPP--VVHLGPGEDRSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFERSLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TSGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVQEL----------------VSDLLS--AEDQKR----EEEREM-- -LAEAMAS--DGFTFVKRHQ---AALIQRLKS-VEPV----------------------- -----------------------LEHLREQNVLSAEEYGSLLAQTSAQQQTARLIELV-- ------------------------------------------------------------ ------------------------------------------------------------ -LNKGNAAAEVFRNWIQKNDVHLLRDLMAQSNEASSPSQDL--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVNIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGLVKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >B_taurus_ENSBTAP00000034604 ----------------------------MNIVEN-SVFLSNLMKSAN-MFEL-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVKDKVKC FCCGLMLDNWKQGDNPIEKHKKLYPSCSFVQNLNSI--NVSGASSQPTFHYSLTNS---- -----------THS-LLPSLENSGY-FSGSYSS-FPSNLLNSGPNQDFSALR-ISSYPCA MNTEKARLLTFQM-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFAC GGTLSNWEPKDDAMSEHLRHFPNCPFLGNQLQGT---------------------SR--- ------------------------------------------------------------ --------------------------------------YTAS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTYAA RIKTF------------------------------------------------------- ---------------------------C---SWPS-SVPVHPEQLASAGFYY-VGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIQI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFISRVQASYPH-LLEQ--LLSTSDNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENTESP--RIERNANQNHYED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MV--------Q-L SHPYM---T--------------------------------------------------- ------------------------------------------------------------ ------------TGKTIGLTRRTFVGTVI------------------------------- ------------------------------------------------------CH--IL TTGLNYL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TICQL----------------LFKLPN--PDRSFV----QQEVNK-- -DTSENEK--DDLSLIRKNR---MALFQHLTC-VLPI----------------------- -----------------------LDSLLTARVISEQEHDVIKQKTQTSLQARELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNFAATIFKNSLQEIDPMLYKRLFVQQDIKYIPTENV--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_musculus_ENSMUSP00000013949 ----------------------------MNMVQD-SAFLAKLMKSAD-TFEL-KYDFSCE LYRLS---------TYSAFPRGVPVS-ERSLARAGFY-------------YTGANDKVKC FCCGLMLDNWKQGDSPMEKHRKLYPSCNFVQTLNPA--NSLEASPRPSLPSTAMST---- -----------MPL-SFASSENTGY-FSGSYSS-FPSDPVNFRANQDCPALS-TSPYHFA MNTEKARLLTYET-------WPLS---FLSPAKLAKAGFY---YI----GPGDRVACFAC DGKLSNWERKDDAMSEHQRHFPSCPFLKDLGQSA---------------------SR--- ------------------------------------------------------------ --------------------------------------YTVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RIRTF------------------------------------------------------- ---------------------------S---NWPS-SALVHSQELASAGFYY-TGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLLRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVSQVQAGYPH-LLEQ--LLSTSDSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENADAA--IVHFGPGES-SED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VV--------M-M STPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVRQTVQ------------------------------- ------------------------------------------------------WQ--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVSDL----------------VIGLLD--AEDEMR----EEQMEQ-- -AAEEEES--DDLALIRKNK---MVLFQHLTC-VTPM----------------------- -----------------------LYCLLSARAITEQECNAVKQKPHT-LQASTLIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LAKGNTAATSFRNSLREIDPALYRDIFVQQDIRSLPTDDI--AA--LPM--EEQ----- ------------------------------------------------------------ -------------------LRKLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KVCMD------------------------- ------------------------REVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRGTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >G_aculeatus_ENSGACP00000027283 --------------------------------KN-NPFLMGLCRNGP-PPDL-QYDNSSE LFRIS---------TFARFP-ASGVT-ERSLARAGWF-------------YIGVGDRVQC FRCNVTAEGWQAGDCPTEKHRQLSPTCSFIQSLPST--TNLLSSSHSAFSPLRIAPAV-- ------------PA-VSQGEEPVGY-LNMGFSAPPPSSPLSSRGVEDMSHQR-PTCHNPS KRKEQDRLDSFHP-------WTLS---IITPSELAKAGFY---YL----GQGDRVACFSC GGQLSNWEPGDRAVSEHQRHYPNCRFLSS-----------------------GAAAL--- ------------------------------------------------------------ --------------------------------------NNVS---NPAM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQSDE RLLTF------------------------------------------------------- ---------------------------V---NWPA-RIPVRPDQLAKAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIQE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVHQIQARFPR-LFEQ--LLANGDNN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SREFIDPP--VVHLGPGEERSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVI---K--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFERGLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TSGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVQEL----------------VLDLLS--AEDQKR----EEEREM-- -VAEAMAS--DGFTFVKRHQ---ATLIQRLKS-VEPV----------------------- -----------------------LEHLREQNVLSPDEYGGLKAQTSAQLQNGKLIELV-- ------------------------------------------------------------ ------------------------------------------------------------ -LTKGNAAAEVFRNWIQKNDVHLLRDLMAQSNEAASPSQDL--SD--LPM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVNIVFIP-----------------CGHLV----- -VCKEC------------------------------------------------------ ---------------------------APSLRKCPICRGLVKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >O_latipes_ENSORLP00000010149 ------------------------------------------------------------ ------------------------VS-PLQLAEAGFL-------------FTGVSDRVRC FSCQKTVENWSQEDQPVDRHIQVSPSCTFLRCTHFNRFK--------------------- ---------------SNPHMPLSNG-GLHDGTEGYIDYQLRTRAIVDET----PYPRNRN MKSEEARLETFSS-------WPRSA--PVRPRDLAQAGLF---YL----GKEDKVECFSC GGKLSGWKPGDTPWNEHEKHFSHCFYILGHDVGN---------------------VPLER DGGENEET-------------------------GSRN----------------------- --------------------------------------QHRT---PVNL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ENLDE RLGTF------------------------------------------------------- ---------------------------A---RV---QHPIDHELLAKAGFYSKVGEGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVICFRC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLKD------------------- ------------------------------------------------------------ -----------------------------------------------------WDPEDNP WEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KY---------------------- -----------YP--GC---SFLLSE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVNTIQLQEPK-YSQQVRHIISPHLR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------NLFLKLLHFPSFCRNTKK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VYFVLCLAYSLLKSWWG------------------------------- ------------------------------------------------------STFLMS SDKRIYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KLQNI----------------KMDFLKRRKLAEPFEKENLSQGSA-- -TFSTCRANQLWIFHRNKT----------------------------------------- -----------------------VIKINLFEIVRTFNRGLHDFLSSLYLSARNLMKNI-- ------------------------------------------------------------ ------------------------------------------------------------ ---------LVFFNMRATKSFVGVKLKVKKHYLLQFYINYIRTGLTIENP--LEE----- ------------------------------------------------------------ -------------------LEKLR------------------------------------ ----------------------------------------------------------QE K----------------------------------------------------------- --------------------------RC-------------------------------- ------------------------------KICLD------------------------- ------------------------ENACIVFIP-----------------CGHLA----- -SCKAC------------------------------------------------------ ---------------------------SNKLNQCPICCAAIAQ---KIRTFI-------- ---------A-------------------------------------------------- ----------- >G_aculeatus_ENSGACP00000003419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MTDDRGTAPRAPEAPR MRGEGERLRTFGR-------WPADA--PVTSGELAGAGFF---YL----GPGDEVQCFCC GGVLKCWARGDRPAAEHRRHFPDCGFALGRPAGN---VPLPAGSSDSVDGQLLSQLQRMT MDEQGTP----------------------------------------------------- --------------------------------------GQAV---HPQL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EAEDT RVTTF------------------------------------------------------- ---------------------------H---NWPA-EASVQPDVLARAGFFY-TGHGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIQE-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDYISNVQDSHFH-LDDT--VSGSQSSA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GRDAGSRN-------DVVGGLAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SS--------A-M LSPVV---Q--------------------------------------------------- ------------------------------------------------------------ ------------TVLQMGFEAALVESLVR------------------------------- ------------------------------------------------------TR--FL LTGQHYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSNL----------------VSDVLQ--AEQEDQ----RGSRSA-- -GNTE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RSEFPRTA---------TD--PSP--EEL----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KLVSIVFIP-----------------CGHLV----- -VCADC------------------------------------------------------ ---------------------------AASLRHCPICRAVIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >O_cuniculus_ENSOCUP00000011948 -----------HKTTSPRVVPG-TVYRTQNMMED-STILXXXXXXXX--XXX-XXXXXXX XXXXX---------XXXXSPNGVPVS-ERSLARAGFY-------------YTRVNDKVKC FCCGLMLDNWKQGDNPIEKHKQLYPSCSFIQNLVS---ASLDSTIKNT-SPVRSSF---- -----------AHS-LSPTVEPGGS-FSGSYSS-LSANPLNSRTVEDFSPLR-TNPYSYS MSSEEARFLTYHM-------WPLS---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPKCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAS RMRTF------------------------------------------------------- ---------------------------M---YWPS-SAPVGPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--XX---XXXXXX-XX------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ XXXXXXXXXXXXX-XXXX--LLSTSDPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--IVHFGPGESSSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSKSLVKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKR----EEEKER-- -QAEEVAS--DDLSLIRKNR---MALFQQLTC-VLPI----------------------- -----------------------LDHLLKANVINKQEHDIIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNVAANIFKNCLKEIDSTLYENLFVEKNMKYIPTEDA--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQGC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >M_domestica_ENSMODP00000000705 ----------------------------MNLVEN-IMFLSNMNISNL--YEL-KYDFSCE LYRIS---------TYSAFPVNVPVS-ERSLARAGFY-------------YTGVNDRVKC FCCGLMLDNWKQGDNAIDKHKQLFPSCAFIQNLTSV--NNLESNSQSALSSSLNSA---- -----------SCS-LSPSSEQSGY-FSGSYSS-FPLEPVTSRGVEDLSPLN-TSPYSYS MSTEEARILTYQA-------WPLT---FLSPLDLARAGFY---YI----GPGDMVACFAC GGKLSNWEPKDDAMSEHRRHFPHCPFLESQIQET---------------------SR--- ------------------------------------------------------------ --------------------------------------FNVS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RVKTF------------------------------------------------------- ---------------------------V---TWPP-QIPVHPEQLANAGFYY-VGCND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIEM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QQFINQIQASYPH-LLEQ--LLSTSDVP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VDENAGLP--IIHFGLGENHAED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTSAV---R--------------------------------------------------- ------------------------------------------------------------ ------------SALEMGFQRRLIKQTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVSDL----------------VSDLLK--AEDETR----EEDE---- -QAEEIES--DDLSLIQKNR---MALFQHLTC-VLPV----------------------- -----------------------LNCLLTASVINEQEYDVIKQKTQISLQVRELIDTI-- ------------------------------------------------------------ ------------------------------------------------------------ -IVKGNIAANIFKKCLRDFDPVLYENLFVEKNMKYIPTEDV--SG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------KIL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >T_rubripes_ENSTRUP00000011958 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MLEEPR MRREGDRIRTFQE-------WPADA--AVAPADLARAGFF---FL----GPGDAVQCFCC GGILRCWMQGDTPGDEHRRHFPTCCFVLGKAVGN---IPLQAGFSDSVDGQLLSQLQRMT MDDQGTV----------------------------------------------------- --------------------------------------GQAV---YPEM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EAEDS RLTTF------------------------------------------------------- ---------------------------H---NWPT-EASVQPDVLARAGFFY-TGHGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NVKCYYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIQT-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYISNIQDTHFH-LGDT--VGGSQSSS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SRDIGPRN--ASHLPDMV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------R--------A-M LSPVV---Q--------------------------------------------------- ------------------------------------------------------------ ------------TVLQMGFEAGLVESLVQ------------------------------- ------------------------------------------------------TK--YL LTGRQYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSDL----------------VSDVLQ--AEQEDR----ARAPQS-- -TVPS---------------------------RSR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ASAHFSP-----------------PPTV---------NE--PSP--EEL----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KLVSIVFIP-----------------CGHLV----- -VCSDC------------------------------------------------------ ---------------------------AASLRHCPICRAVIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000029187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VPPN MRSEAERQRSFRA-------WPHTC-RTVSPAELARSGFY---YL----GPGDRVQCFSC GGVLRSWEPGDRPDTEHRKFFPSCPFLQVRRGPP--------GGTDSVDGQILGQLSGEE PDRT-------------------------------------------------------- --------------------------------------WEPV---CPQM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AGEGD RLGSF------------------------------------------------------- ---------------------------S---TWPR-YANGDPQQLAGAGFFY-TGHRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HVKCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEQGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--MC---DFLLQV-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EAFIRSVQESFFS-SPETSPESVGSYEGSP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VSSPGSPPVCPFL STSVA---Q--------------------------------------------------- ------------------------------------------------------------ ------------GALQVGFKRNRVSSLMI------------------------------- ------------------------------------------------------NR--FI LTGSCYG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSEL----------------VTDLIR--AEEIHG----TESVSV-- -PRAP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TQRERPEPPKEPA--PP--LST--EEQ----- ------------------------------------------------------------ -------------------LRQLK------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KVCMD------------------------- ------------------------NDVSMVFVP-----------------CGHLV----- -VCTEC------------------------------------------------------ ---------------------------APNLRHCPICRAAIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >O_cuniculus_ENSOCUP00000008710 ----------------------------MNIVEN-SIFLANLMKSAN-TFEL-KYDFSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKQGDKPIEKHRKLYPSCSFVQSLNSV--NNWEANSRSTFPSSVTNS---- -----------THS-FLPSWEHSGY-YSGSYSS-LPSNPVNSRANQDFSAFR-VSPYHSA MSTEKARLLTFQS-------WPLT---FLSPMDLAKAGFY---YV----GPGDRVACFAC GGKLSNWEPKDDAMSEHLRHFPNCPFVENQLQDA---------------------SR--- ------------------------------------------------------------ --------------------------------------YTIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RFKTF------------------------------------------------------- ---------------------------F---NWPS-SLLVHPEQLASAGFYY-VGHSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WELGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFISXXXXXXXX-XXXX--LLSTSDTP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EDENAEPP--XXXXXXXXXXXXX--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------XX--------X-X XXXXX---X--------------------------------------------------- ------------------------------------------------------------ ------------XXXXXXXXXXXXXXXXX------------------------------- ------------------------------------------------------XX--XX XXXXXXX----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------XXXXX----------------XXXXXX--XXXXXX----XXXXXX-- -XXXXXXX--XDLSLIRRNR---MALFQHLTC-VIPI----------------------- -----------------------LDSLLTSGVINEQEHAVIKQKTQTSLQARELIDII-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNYPATVFQDCLPGFDPVFSMYLF-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >D_melanogaster_FBpp0086432 ---------------------------------------------------MTELGMELE SVRLA---------TFGEWPLNAPVS-AEDLVANGFF-------------ATGNWLEAEC HFCHVRIDRWEYGDQVAERHRRSSPICSMVLAPNHCGNVPRSQESDN------------- ----------------------------------------EGNSVVDSP----ESCSCPD LLLEANRLVTFKD-------WPNP---NITPQALAKAGFY---YL----NRLDHVKCVWC NGVIAKWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNLDELGIQPT----------- ------------------------------------------------------------ --------------------------------------TLPL---RPKY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ACVDA RLRTF------------------------------------------------------- ---------------------------T---DWPI-SNIQPASALAQAGLYY-QKIGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QVRCFHC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NIGLRS------------------- ------------------------------------------------------------ -----------------------------------------------------WQKEDEP WFEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------SP--KC---QFVLLA-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PAYVSEVLATTAA-NASSQPATAPAPTL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------QADVLM DEAPA------------------------------------------------------- ------------------------------------------------------------ -----------KEALALGIDGGVVRNAIQ------------------------------- ------------------------------------------------------RK--LL SSGCAFS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLDEL----------------LHDIFDDAGAGAALEVREPPEPSAPF IEPCQAT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -TSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSL--EEE----- ------------------------------------------------------------ -------------------NRQLK------------------------------------ ----------------------------------------------------------DA R----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KVCLD------------------------- ------------------------EEVGVVFLP-----------------CGHLA----- -TCNQC------------------------------------------------------ ---------------------------APSVANCPMCRADIKG---FVRTFL-------- ---------S-------------------------------------------------- ----------- >D_rerio_ENSDARP00000075338 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G MRSEEERLQTFHN-------WPSDA--AVSPEELARAGFH---YL----GYGDTVQCFCC EGILRHWVDGDTPRGEHERHFPTCGLMRGRDVGN---VP--RGSSDSVDDS--------- ------------------------------------------------------------ -----------------------------------------------EM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ETEDN RRSTF------------------------------------------------------- ---------------------------H---NWPT-GAAVQPDTLARAGFFY-TGHGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NVKCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--QC---EYLLQS-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYVRNVQQSFFN-MNGR--GVRKNDAP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QQQFMLSQPTFHPGTEVLGGQRS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VA--------APM LSPVV---Q--------------------------------------------------- ------------------------------------------------------------ ------------AVLQMGFQHSLVESLVQ------------------------------- ------------------------------------------------------SR--FL LTGAHYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSDL----------------VTDVLQ--AEEEEE----RQTGDT-- -RSGVAHPLFANTLLYQNKIKLYYVCLKKKINMLKHF----------------------- -----------------------KSNLLNNYINKINNNNYSHNNFFYFTKKSLKMIFI-- ------------------------------------------------------------ ------------------------------------------------------------ -IIKMQLTRIIYFHWFNINDVCLLRDCGDAENTKNDKNKNAVRSD--LSP--EEQ----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KLVSMVFIP-----------------CGHLV----- -VCSDC------------------------------------------------------ ---------------------------AASLRHCPICRAVIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >T_nigroviridis_ENSTNIP00000006583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MRREKDRIRTFRE-------WPADA--AVAPADLAKAGFF---FL----GPRDAVQCFCC GGILRCWVQGDSPGDEHRRHFPTCCFILGRAVGN---IPLQAGSSDSVD----------- ------------------------------------------------------------ -----------------------------------------------EM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EAEDS RLTTF------------------------------------------------------- ---------------------------H---NWPT-EASVQPDVLARAGFFY-TGHGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NVKCYYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIQT-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEYISNIQDAHFH-LGDT--LSSSSRDI-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GPRN--ASPLPDMIGGLAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SS--------A-L LSPVV---Q--------------------------------------------------- ------------------------------------------------------------ ------------TVLQMGFDSSLVESLVQ------------------------------- ------------------------------------------------------TK--YL LTGRQYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSNL----------------VSDVLQ--AEQEDR----ETAPQS-- -RVSKSGGCLRWCSYCVCSCCDYLVCAFQSQRRGR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -APVLLASEHIWPLEKKLSHLSFLREPALIPLTV---------NE--PSP--EEL----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KLVSIVFIP-----------------CGHLV----- -VCSDC------------------------------------------------------ ---------------------------ATSLRHCPICRAVIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000000045 ----------------------------------------------------------ME SYRLS---------TFMKYPQDTPVN-PRHLAAAGFH-------------YTGYKDRVKC FCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG---NQPIGSQNISVQQTARPV--- -PAGMIMKS-----GPSEFRFTFVI--LTFLTLYSTR--PKVELATIASPYHEQLVRSLD LRKESDRFKTYEN-------WPAQN-RTVYASDLARSGFF---YL----GNLDRVQCFSC GGVLRNWNYGDNITAEHRRHFPHCRFVRKKTVYQ-TAN---------------------- ----VLRG---------------------------------------------------- --------------------------------------GFFTNQFIPYM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RNEES RFETF------------------------------------------------------- --------------------------DH---RWPASNVRASPRQIAKAGFFF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDPDDEP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TH--REVVGKY-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PDFVHRMVSLYPN-LPRP--IL---RGPFDVPPRVPG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ANQRAPSPPPPIIDHKVAKQQEQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VN--------KFM LGDLV---K--------------------------------------------------- ------------------------------------------------------------ ------------SATEMGFETSVIRRVVT------------------------------- ------------------------------------------------------RR--LT SGGNLYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVADL----------------VDDITA--NENEPN----SDDDDE-- -TNASQPSQTTTVKTPGDYDVINVTIVLRYIL-DRPI----------------------- -----------------------IHCKQEQTKWRPV-------KQKQQLEELFDRHFI-- ------------------------------------------------------------ ------------------------------------------------------------ -KFFRNKVGIKSLKIITNIVWWWLRYVT-------------------PSM--EAR----- ------------------------------------------------------------ -------------------IRELQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------KC-------------------------------- ------------------------------KICLD------------------------- ------------------------KVADIVFVP-----------------CGHLC----- -TCTEC------------------------------------------------------ ---------------------------AEALRKCPICRSKIRERDQNLHIYV-------- ---------GW------------------------------------------------- ----------- >T_guttata_ENSTGUP00000007779 ------------------------------------------------------------ ------------------------------------------------------------ -----------MGDAAPAQQPEPRAAR--------------------------------- -----------------------------------------------------RRLFEAS MRSVARRLRTFQQ-------WPRTA--PVSARDLVEAGFF---YL----GPGDEVQCFCC GGILKDWRPGDCPMIEHLHFFPSCKYLSGEDVGNQEMLSL-QEIFDTVDGQFLSVLQGIV SEETAQP----------------------------------------------------- --------------------------------------NEPE---YPEM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VTEEM RLSTF------------------------------------------------------- ---------------------------E---NWPQ-NSSMHPEQLARAGFFY-TGRGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVRCFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGVRS------------------- ------------------------------------------------------------ -----------------------------------------------------WSFGDDP WREHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--EC---EFLLHS-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ REFVNSVQATFSI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GKDESQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LST--EEQ----- ------------------------------------------------------------ -------------------LRRLR------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KDVSVVFVP-----------------CGHLV----- -ACEEC------------------------------------------------------ ---------------------------ALNLRLCPICRAGIQG---RVRAFM-------- ---------S-------------------------------------------------- ----------- >G_gallus_ENSGALP00000009239 ------------------------------------------------------------ ------------------------------------------------------------ -----------MADTAPVEGTHLRATC--------------------------------- -----------------------------------------------------CHLFNYS MRDEARRLRTFSQ-------WPRSS--PVSAWDLAKAGFF---FV----GPGDQVQCFSC GGILKDWEPGDCPIVEHLKFFPFCKFIYHGAVWNQQ-VPL-QGVFDSVDGQILSLLQRID SEETALP----------------------------------------------------- --------------------------------------NQPE---YPEM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VTEEM RLSTF------------------------------------------------------- ---------------------------Q---NWPQ-YTEMRPEQLARAGFFY-TGQGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVRCFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGMRN------------------- ------------------------------------------------------------ -----------------------------------------------------WAFGDDP WREHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------YP--RC---EFLLRS-MG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ REFVSSIFTDECL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SKEESP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LST--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KVCMD------------------------- ------------------------RDVSVVFVP-----------------CGHLV----- -ACGEC------------------------------------------------------ ---------------------------ALNLRLCPICRAVIQG---SVRTFM-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000005161 -------------------------------------------------------DSAME SYRLS---------TFMKYPQDTPVN-PRHLATAGLY-------------FTGYKDRVKC FCCGLATEQWQFGDD-EKSPRWHRSNCEFIQGHDCG---NIPIGLHCVVKYKLLMELTIP IFLGSWGWI-----RPDNTARENFM-NVTYLNLGEKNFFQRIELATISSVYHEQVLRSLD LKKEGERMKSFEN-------WPTQN-RTVNPSDLARSGFF---YL----GNLDRVQCFSC GGVLRNWNYGDNITAEHRRHFPHCRMTQGTESNN-------------------------- ----RELE-------------------------MMFPC---------------------- --------------------------------------QHPV---NSHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RHLDS RIVTF------------------------------------------------------- --------------------------DS---RWPKNKTQATIQQIAKAGFFY-LGERD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDPDDEP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TC---EFLIRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PDFVHHMVSLYPN-LPRP--ILQTAQGA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------NGSQSSGTSSAPIIIDPQKRKLREK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LNLEM DRDIV---K--------------------------------------------------- ------------------------------------------------------------ ------------CVNDMGFELKHIRLCVK------------------------------- ------------------------------------------------------RK--LE KENIGFS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SAQQL----------------IDEILKLNLDEEEE----EELDLE-- -TDPKEPAAMETEGGKLYHEVKPSNFKRYLDQRCT------------------------- -----------------------INIRLKLDLTTIVMHRFINQRFIPYVNTVRLETTN-- ------------------------------------------------------------ ------------------------------------------------------------ -RSKNDLYYFKYLKQNWLTNGACMVDLT-------------------MSM--QDR----- ------------------------------------------------------------ -------------------LLELQ------------------------------------ ----------------------------------------------------------NE R----------------------------------------------------------- --------------------------KC-------------------------------- ------------------------------KICVD------------------------- ------------------------KLSDIVFVP-----------------CGHLC----- -VCQAC------------------------------------------------------ ---------------------------KSKVARCPICKSKVEK---SIRTYM-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000009820 -------------------------------------------------------DAAME SYRLS---------TFMKYPQDTPVN-PRHLAAAGFH-------------YTGYKDRVKC FCCGLCVENWVSGDE-IKSKKWHRNNCELVNGNGSG---NQPIAGDDF--KSTISPLCEC KALSMVLKT-----PKIQGCRKFSM-PLSFFV--------RIELATIASPYHEQLVRSLD LRKESDRSKTYEN-------WPAQN-RTVYASDLARSGFF---YL----GNLDRVQCFSC GGVLRNWNYGDNITAEHTRHFPHCSLF--------YAQ---------------------- ----LELS-------------------------EMFPC---------------------- --------------------------------------QYPV---NPHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RNQDM RLATF------------------------------------------------------- --------------------------DQ---RWQQRALQAKPAQISKAGFFF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDPNDEP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TC---EFLIRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PDFVHAMVSKYPN-LPRP--IL---RGPFDVPPSIRR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------NSE--STAPPPIMDHKMAEMKTK--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VK--------KHM ESEEA---K--------------------------------------------------- ------------------------------------------------------------ ------------SVLEMGFGRKELEKVIK------------------------------- ------------------------------------------------------KK--LK KDGKMFK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVVSI----------------IDAM------NDGT----DSSDDE-- -MEADEPQTQTPMSI-SDLGRKGLF----------PC----------------------- -----------------------IGCILKIV----I-------RFKNHINTKYKTNYH-- ------------------------------------------------------------ ------------------------------------------------------------ -KVHTPQIKIK----------YYPTDLS-------------------PSM--LAR----- ------------------------------------------------------------ -------------------VAELE------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------KC-------------------------------- ------------------------------KVCLD------------------------- ------------------------KMADIVFIP-----------------CGHLC----- -TCIEC------------------------------------------------------ ---------------------------ASALNKCPICRKRIEK---SIRTYL-------- ---------N-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000002256 ----------------------------------------------------------ME SYRLS---------TFMKYPQDTPVN-PRHLAAAGFH-------------YTGYKDRVKC FCCGLCVESWCVGDD-VKSPRWHRSNCEFILGQDCG---NQPI-DHMVWLQVVCSAT--- -LCDHLVQL-----GQG------------------------------------------- ---------------------------GIYSETLA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GYVT---CPYM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RNEES RFETF------------------------------------------------------- --------------------------DH---RWPASNVRASPRQIAKAGFFF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDPDDEP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TC---EFLLQR-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PDFVHRMVSLYPN-LPRP--IL---RGPFDVPPRA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVAKQQEQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VN--------KFM LGDLV---K--------------------------------------------------- ------------------------------------------------------------ ------------SATEMGFETSVIRRVVT------------------------------- ------------------------------------------------------RR--LT SGGNLYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVADL----------------VDDITA--NENEPN----SDDDDE-- -TNASQPSQTTTVKTPD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VT-------------------PSM--EAR----- ------------------------------------------------------------ -------------------IRELQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------KC-------------------------------- ------------------------------KICLD------------------------- ------------------------KVADIVFVP-----------------CGHLC----- -TCTEC------------------------------------------------------ ---------------------------AEALRKCPICRSKIER---GIKTYM-------- ---------S-------------------------------------------------- ----------- >O_latipes_ENSORLP00000012199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------M----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RRERE RLQTF------------------------------------------------------- ---------------------------Q---NWPD-EAPVTSEDLAKAGFYF-LGSED-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVKCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPGDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIHS-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDYINNIQDAHFH-LGNS--GEKLLYLH-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FKLADMVGGLGA--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SS--------A-M LSPVV---Q--------------------------------------------------- ------------------------------------------------------------ ------------TVLQMGFEDSLVQSLVQ------------------------------- ------------------------------------------------------TK--YL LTGQHYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVSDL----------------VTDVLQ--AEEEER----QRGANS-- -RGSAV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KE--ASP--EEL----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KLVSIVFIP-----------------CGHLV----- -VCGDC------------------------------------------------------ ---------------------------AASLRHCPICRAVIRG---SVRAFM-------- ---------S-------------------------------------------------- ----------- >G_gorilla_ENSGGOP00000008137 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RNSF---- -----------AHS-LSPTLEHSSL-FSGSYSS-LSPNPLNSRAIEDISSSR-TNPYSYA MSTEEARFLTYHM-------WPLT---FLSPSELARAGFY---YI----GPGDRVACFAC GGKLSNWEPKDDAMSEHRRHFPNCPFLENSL-ET---------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NLSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QTHAA RMRTF------------------------------------------------------- ---------------------------M---YWPS-SVPVQPEQLASAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DVKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRC------------------- ------------------------------------------------------------ -----------------------------------------------------WESGDDP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVDEIQGRYPH-LLEQ--LLSTSDTT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--XXXXXXXXXXXXX--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------XX--------X-X XXXXX---X--------------------------------------------------- ------------------------------------------------------------ ------------XXXXXXXXXXXXXXXXX------------------------------- ------------------------------------------------------XX--XX XXXXXXX----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------XXXXX----------------XXXXXX--XXXXXX----XXXXXX-- -XXXXXXX--XXXXXXXXXX---XXXXXXXXX-XXXX----------------------- -----------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-- ------------------------------------------------------------ ------------------------------------------------------------ -XXXXXXXXXXXXXXXXXXXXXXXXXXXXDKNMKYIPTEDV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSVVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >A_aegypti_AAEL006633-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E LKREEHRLATYVN-------WPIS---HISPSSLAKAGFY---YT----YNADQVKCAWC EGVIGQWELGDDPFVEHQKFFPNCAKVISNGISSNPILDPTIGIQPV------------- ------------------------------------------------------------ --------------------------------------KTPY---APQF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SSLDS RIRSF------------------------------------------------------- ---------------------------E---NWTT-GHIQDPERLAQAGFYY-LGRAD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVHCFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRF------------------- ------------------------------------------------------------ -----------------------------------------------------WLADDDP WFEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RC---------------------- -----------FP--KC---QFVQLV-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QLFIENVQSQIKS-TSSNQQQQMQASGP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TMSLDEAL ATEPV---Q--------------------------------------------------- ------------------------------------------------------------ ------------LALSMGLNAGRIRAVTK------------------------------- ------------------------------------------------------RQ--LD STGHPYA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DSQAL----------------IEAVLDGQIQDEELEPSTSSRMDR-- -RIESEVSRLLWTAISSTAGPNLSSFSSTFSTPSPSF----------------------- -----------------------DSAPTSDGDVIVSSDPLSSPSTSSIANNASTSSAV-- ------------------------------------------------------------ ------------------------------------------------------------ -KCNNVPESLAQMAAAARPTETAEVDKT-------------------LRL--EEE----- ------------------------------------------------------------ -------------------NKRLK------------------------------------ ----------------------------------------------------------DA R----------------------------------------------------------- --------------------------EC-------------------------------- ------------------------------KICMA------------------------- ------------------------DEVGVVFCP-----------------CGHLV----- -SCVQC------------------------------------------------------ ---------------------------APAVTNCPVCRAVIKG---RVRTFL-------- ---------S-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000030727 ----------------------------NEILDR-RPDLAKRLKSNPSMCKI-TLEFSCE LYRLS---------TFSSFPSNTHVS-ERNLAKAGFY-------------YTGQDDKVKC FTCGLMLDNWKKGDNAFEKHKKLYPSCSFIQNVPSV---NLGASLYSAFSPPASNS---- -----TP----MHA-ASAENDKVEA-ITLKYSS-IPQDPVTLRGIEDLSHVR-ISEY--- MYTEEARLNSFQE-------WSNM---FLTPAELAKAGFY---FV----GPGDKVACFTC DGKLNNWEPNDNAMSEHRRHFPNCPFVKSSTRVS---------------------SR--- ------------------------------------------------------------ --------------------------------------FSVS---NVSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QASSA RLKTF------------------------------------------------------- ---------------------------A---SWPP-RIPISPTRLAEAGFYY-VGRND-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_domestica_ENSMODP00000021022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------V----GPQDRVQCFCC GGMLDNWMAGDSPILEHQRFFPKCQFALSKHTGNIPA----QDTSDSVDGQILSQLQRIS EEGEGEGNEDTVT----------------------------------------------- --------------------------------------TRPV---YPDM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GVEQI RLASF------------------------------------------------------- ---------------------------H---NWPS-AAVVCPQQLARAGFFY-TGQHD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------HVKCYYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGGLRN------------------- ------------------------------------------------------------ -----------------------------------------------------WDRGDDP WREHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLLQS-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RAYVNSIQDSSS--LLDSWGHGEDPQEV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--TS TPASVPM----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ASESTP--PRRESQ----PEQITE-- -TDPLSVFLYLCSLTLSTGP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LST--EQQ----- ------------------------------------------------------------ -------------------LQQLK------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMY------------------------- ------------------------QVVSIVFVP-----------------CGHL------ -VCSEC------------------------------------------------------ ---------------------------APNLQQCPICRAAIHG---SIRTFL-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000000466 ------------------------------------------------------------ ----------------------------MELANNLFS----------------------- ------------------------------------------------------------ ---------------------------------DIETDGMKVNTTSEPSDKRCVYITPGQ KEREDYRITTFNK-------FPSNK--PVDKMKLSSNGFL---YT----GFKDRVKCFRC GQCVEGLNGTEN-MGLPGWHKPDCEFANGTDTTNVPLLRHKIQQNLPSLQNASFVQSIPN QDQTTLSAGELLKFGNIDQTTNQVVTPRNLPVQQSSNQFGQMYQTATIHKPHLQVPFSVL QSTRATEPAPRCAENSQFPC------------------SNPR---NPHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------KSERV RLQTF------------------------------------------------------- --------------------------MNNLGKWSSHGIVTTPEQMADAGLFY-LSDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RTKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPNDDP WYEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--EC---EFVLQQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ELYVHRIARQFPN-LNRP--RISNPYQL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------FGRSNNDVPPPQPQPQSPGPVIIDPQEEQRKL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------KSKIDEEME SSAVV------------------------------------------------------- ------------------------------------------------------------ -----------DGAKQMGFEEKEIKRAIT------------------------------- ------------------------------------------------------KN--MK ENGKSFS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLLSL----------------VDAILADSDDDNTSSEEQSEAPTA-- -PETTLTFNTDQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QST--ASE----- ------------------------------------------------------------ -------------------LQRLE------------------------------------ ----------------------------------------------------------MA R----------------------------------------------------------- --------------------------FC-------------------------------- ------------------------------KICRQ------------------------- ------------------------KEAVVVLLP-----------------CGHLS----- -CCDTC------------------------------------------------------ ---------------------------GKKITKCPTCKLAVTD---KVHSFI-------- ---------A-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000021651 --------------------------MLVDSFCSNLKYQTMFHNIDRVSQHAAAMDYSSK SNRIQ---------SLENFP-SAPVN-PIQLAIHGFY-------------FTGVEDCVVC FSCENSVRNWKLGDKEGDK-KWHKPDCVFFNSLSQTVNDTNISTPNHQ------------ ----------------------------------DMNHFVNTNPTEVVFET--MLLKRLT HKSIKLNIRTFDY-------WPHQL-REVNTAALAKYGFY---YL----GISDMVECFCC SNVLGNWNVDDNPKNRHLERFPNCRWVADVEVHQHPHL---------------------- ------------------------------------------------------------ --------------------------------------LHPH---NAHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RSLEQ RRSSF------------------------------------------------------- --------------------------RG---FSPRHHLRATIDEIAEAGFYF-LGPGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GNKLKN------------------- ------------------------------------------------------------ -----------------------------------------------------FDVEDEP WMEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--QLSIPEFLLQN-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HAFVANIQTSYPR-NVHVVNLPSVESGP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TFL PSPIQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------NHETLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------HEKVDNI--SSG----- ------------------------------------------------------------ -------------------QSNSN------------------------------------ ----------------------------------------------------------SQ L----------------------------------------------------------- --------------------------CC-------------------------------- ------------------------------KVCLN------------------------- ------------------------RDATIAFNP-----------------CGHLC----- -VCQSC------------------------------------------------------ ---------------------------SPRLNACPICRRSIQQ---KIRIYF-------- ---------P-------------------------------------------------- ----------- >B_taurus_ENSBTAP00000004317 MATQEKAPEERISQFDYALLPEMSAFLGVNALQFVKEIEEKEHRDREKMQKGFNSQMRSE AKRLK---------TFVTYNTFRSWT-SQEMAEAGFY-------------LTGTKSGIQC FCCSLILFGTSLQNTPMEHHKKFHPDCEFLLGKDVGNIAKYDVRVQKPENTL-------- -----------------------------------------------------RRDDKAR YQEEKARLESFKN-------WPFYA-QGTSPRELSAAGFV---FT----GKHDTVQCFSC GGCLGNWEDDDDPWKEHAKWFPKCEFLQSKKSLEEITQYIQSYKGFVDVTGEHFLNSWVK RDLSVAS----------------------------------------------------- --------------------------------------VCCNGSNSSSF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VNEEL LLQSF------------------------------------------------------- ---------------------------K---SWHP-SYPVGAAALAKAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCYSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGYLHD------------------- ------------------------------------------------------------ -----------------------------------------------------WKEGDDP LEEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--NC---QFLQSV-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEAIPDLQSHDE-LSELTETTNEGNLEESTAVSSIVP---------------------- ----------------------EVAQGEAQWFQEAESLSEHLRKVYTSAPFCHMSLLEIS SCLATD-QWLDCDLSFALKHITNPVQEPVVLPEVFANLNSVMCVEGEAGSGKTILLKKIA HLWASGRCPLLNRFRLVFCLSLGSTRPEQGLASVIRDQLLETKLS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTEMGLRNIIQQL KNQVLFLLDDYKEMCSVPQVIARMIQKKHLSRTCLVITVRTNRAKNIRRYLDTIIEIKAF PFYNTISILRKLFPGDLTRLRKLMVDFGMNQTWQGIQKTPLFVAAVRASWLQNRFHR-SF DSVAVFESYMECLFLKHKTEADLLKATVSSCGDLALKGFFSSCFEFSDEDLIEAGIGEEE DLAMYLMSKFTAQRLRPVYQFLNPAFQEFLAGMRLTELLDSDRQEDQDLGLHYLKR--IN STLMVIY----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PYANFLNCVSRHPSTKAGPKIVSHLLLLVDNKETLENISENDDYL-- -KHHPEISEVMQ-FFRLIWQLSPQNYLSLASKHLLAL----------------------- -----------------------AIRIAYQSNTVAACSPFILQFLRGRTLCLDVLKLQ-- ----YFFDHPESLLLLRSIQVSINGNRLF-KTD-TPLERIFDKSQAPTIEQDYASAFELE SEWKQSLDEKHEIIQNFQNMRLNAPPAINTGYWNLPSKQYKIPLLEVHVTNTHAVDQEML RFLTEVFSAAQHIELHLNHSRGFIENIRPALEQFRASFTKCCISQCELSAIEQEL----- ------------------------------------------------------------ -------------------LLTLTSLESLEVSETTHPQDQLFLSLDKFLCLKELSVNLQ- -QDVFSAISEEFLNLHHMEKLLI-QISSKCSPSKLVRLVQNSPNLQVFHLECNSFSDFES LV---------------------------------------------------------- ----------------------TALASR-------------------------------- ------------------------------KKLEEIKFSGQFFQANPFVIVLPNFTSLKI LKLGIQYIPDKETAEKFAYALGSLNNLEELILP-----------------TGDGIHQMAK LIIQQCQHLQCLQVLQFFKTLDDDSVVEIAKVAIN-GGFQKLKHLDFSMNHKITEEGYRN FFQTLDNLPSLQELTISRHFKECIKVQAATVKSLSQCVLRLPS---LLRLNMLSWLLDAE DITLLTATIKKHPQSKHFILS----------------------------------WKWIL PFSPIIQEPIS >M_musculus_ENSMUSP00000058611 MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSE AKRLK---------TFETYDTFRSWT-PQEMAAAGFY-------------HTGVRLGVQC FCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKRPEKML-------- ------------------------------------------------------RGGKAR YHEEEARLESFED-------WPFYA-HGTSPRVLSAAGFV---FT----GKRDTVQCFSC GGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQSYEGFVHVTGEHFVKSWVR RELPMVS----------------------------------------------------- --------------------------------------AYC---NDSVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ANEEL RMDMF------------------------------------------------------- ---------------------------K---DWPQ-ESPVGVEALVRAGFFY-TGKKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVRCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCLEK------------------- ------------------------------------------------------------ -----------------------------------------------------WAEGDDP MEDHI------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--EC---VFLQTL-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPTLQSQYA-LPEATETTRESNHGDAAAVHSTVV---------------------- ----------------------DLGRSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVC SSLGTD-HLLSCDVSIISKHISQPVQEALTIPEVFSNLNSVMCVEGETGSGKTTFLKRIA FLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLGAGGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISEVCLSSSIQQL QHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEF PFYNTVSVLRKFFSHDIICVEKLIIYFIDNKDLQGVYKTPLFVAAVCTDWIQNASAQDKF QDVTLFQSYMQYLSLKYKATAEPLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDE KLTTLLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQ--ID SPLKAIN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESLENMSENEDYM-- -KLHPQTFLWFQ-FVRGLWLVSPESSSSFVSEHLLRL----------------------- -----------------------ALIFAYESNTVAECSPFILQFLRGKTLALRVLNLQ-- ----YFRDHPESLLLLRSLKVSINGNKMSSYVDYS-FKTYFENLQPPAIDEEYTSAFEHI SEWRRNFAQDEEIIKNYENIRPRALPDISEGYWKLSPKPCKIPKLEVQVNNTDAADQALL QVLMEVFSASQSIEFRLFNSSGFLESICPALELSKASVTKCSMSRLELSRAEQEL----- ------------------------------------------------------------ -------------------LLTLPALQSLEVSETNQLPEQLFHNLHKFLGLKELCVRLDG KPNVLSVLPREFPNLLHMEKLSI-QTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSNCES LM---------------------------------------------------------- ----------------------AVLASC-------------------------------- ------------------------------KKLREIEFSGRCFEAMTFVNILPNFVSLKI LNLKDQQFPDKETSEKFAQALGSLRNLEELLVP-----------------TGDGIHQVAK LIVRQCLQLPCLRVLTFHDILDDDSVIEIARAATS-GGFQKLENLDISMNHKITEEGYRN FFQALDNLPNLQELNICRNIPGRIQVQATTVKALGQCVSRLPS---LIRLHMLSWLLDEE DMKVINDVKERHPQSKRLIIF----------------------------------WKLIV PFSPVILE--- >R_norvegicus_ENSRNOP00000024483 MAEHGEASEDQVSEFDGECLPELSALLGVDAVQLVKSQEEEENKERMKMKKGFNAQMRSE AKRLK---------TFVTYDAFKSWT-PQEMAAAGFY-------------YTGVRHGVQC FCCSLILFGTSLRKVPIESHRKLRPQCEFLSGKDVGNIGKYDIRVKNPETLP-------- ------------------------------------------------------RGGRAR YHEEEARLESFED-------WPFYA-HGTSPRVLSAAGFV---FT----GKRDTVQCFSC GGCLGNWEEGDDPWKEHAKWFPKCEFLQSKKSTEEINQYIQSYTGFLHVAGEHFVNSWVR RELPVVS----------------------------------------------------- --------------------------------------AYS---NDSVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ANEGL RMDTF------------------------------------------------------- ---------------------------K---DWPH-ESSVAVEALVKAGLFY-TGKKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCMEN------------------- ------------------------------------------------------------ -----------------------------------------------------WKEGDDP IEDHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--NC---VFLQTL-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPALQSHCA-CPEAMETTSESNHEDPVAVHSSVA---------------------- ----------------------GLGQSEAQWCQEARSLSEQLRGTYTKASFRHMNLPEAY SSLGTD-HLLGCEVFLISKHVSRPVQVALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIA FLWASGCCPLLNRFQLVFYLSLRSIRADQGLADIICAQLLEAGGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISEVSLSSGIQHL QHQVLFLLDDYSGMDSLPQALDTLITKNYLSRTCLLMAVHTNRVRDIRPYLETVLQIKEF PFYNTISVLRKFFSHNTTRLLEFMVYFGRNEDLQGVHKTPLFVAAVCTDWFQNPSDQ-PF QDVTIFKSYMQYLFLKHKATAGPLQATVSSCGHLALTGLFSSSFEFSSDDLIEAGVDEDE ELSTCLMSKFTAQRLRPVYRFLSPLFQEFLAAMRLSELLGSDSQEDQDLGLYYLRQ--IN SPLKAIN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SYGIFLKYVSDHCSSKAGPKVVSHLLQLVDEKESLENMSENEDYM-- -KLHPETFLWLH-FLRGLWLNSPESFSSLLSERLLNI----------------------- -----------------------ALNFAYQSSTVAACSPVILQFLRGRTLALGVLNSQ-- ----YFWDHPESLLLLGSLKVSINGNEISSHVDYS-FKTYFENLQPPAIDKEYTSAFEHI SEWKRNFAEDEKIIKHYQNIWPRVLPDISEGYWKLSPKPYKIPRLEVGVNNMGPADQALL HVLMEVFSASQSIEFQLFNSSGFLESIRPALELNKTSVTKCSMSRLELSRAEQEL----- ------------------------------------------------------------ -------------------LLTLPALQSLEVSETNQIPDQLFHNLDKFLGLKELSVRLDG TQDVLSVLPGEFPNLHHMEKLSI-HTFTESDLSKLVKLIQNSPNLHDIHLKCDFLSNCES LM---------------------------------------------------------- ----------------------AALASC-------------------------------- ------------------------------EKLREIEFSGRCFEAMPFVTLLPNFVFLKI LNLKGQQFPDKETSEMFAQALGSLRKLEELHLP-----------------KGDGIHQVAK LIVQQCLQLPCLRVLAFHHVLDDDSVTEVARVATS-RGFQKLENLDLSMNHKITEEGYRN FFQALDNLPNLQELNICRHIRECIQVQASTVKALGQCVSRLPS---LTRLRMLSWLLDEE DMKVINDVKERHPQSKRLTVF----------------------------------WKWIV PFSPVVQE--- >M_musculus_ENSMUSP00000112867 MAEHGESSEDRISEIDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSE AKRLK---------TFESYDTFRSWT-PQEMAAAGFY-------------HTGVKLGVQC FCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKML-------- ------------------------------------------------------RGGKAR YHEEEARLESFED-------WPFYA-HGTSPRALSAAGFV---FT----GKRDTVQCFSC GGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQDYEGFVHVTGEHFVKSWVR RELPMVS----------------------------------------------------- --------------------------------------AYC---NDSVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TNEEL RMDMF------------------------------------------------------- ---------------------------K---DWPQ-ESPVGFEALVRAGFFY-TGKKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVRCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCLEK------------------- ------------------------------------------------------------ -----------------------------------------------------WAEGDDP MEDHI------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--EC---VFLQTL-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPTLQSQYA-LPEATETTRESNHDDAAAVHSTVV---------------------- ----------------------DLGRSEAQWFQEARSLSEQLRDTYTKTSFCHMNLPEVC SSLGTD-HLLGCDVSIISKHVSQPVQGALTIPEVFSNLSSVMCVEGEAGSGKTTFLKRIA FLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICTQLLGAGGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISEVCLSSSIQQL QHQVLFLLDDYSGLASLPQALHTLITKNYLFRTCLLIAVHTNRVRDIRPYLGTSLEIQEF PFYNTVFVLRKFFSHDIICVEKLIIYFSENKDLQGVYKTPLFVAAVCNDWNQNASAQDDF QDVTLFHSYMQYLSLKYKATAESLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDV KLTTFLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQ--ID SPLKAIN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESLENMSENEDYM-- -KLHPQTFLWFQ-FVRGLWLVSPESFSSFVSEHLLRL----------------------- -----------------------ALIFAYESNTVAECSPFILQFLRGRTLALRVLNLE-- ----YFWDHPESLLLLRSLKVSINGNKMSSYVDYS-FKTYFENLQPPAINEEYTSAFEHV SEWRRNFAQDEEIIKNYENIWPRALPDISEGYWNLSPKPCKIPKLEVQVNNMGPADQALL QVLMEVFSASQSIEFHLFNSSGFLESIRPALELSKASVTKCSMSRLELSRAEQEL----- ------------------------------------------------------------ -------------------LLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCVRLDG KPDVLSVLPEEFLNLHHMEKLSI-RTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSNCES LM---------------------------------------------------------- ----------------------TALASC-------------------------------- ------------------------------KKLREIEFSGQCFEAMTFVNILPNFVSLKI LSLKGQQFADKETSEKFAQALGSLRNLEELLVP-----------------TGDGIHQVAK LIVRQCLQLPCLRVLAFHDILDDESVIEIARAATS-GSFQKLENLDISMNHKITEEGYRN FFQALDNLPNLQMLNICRNIPGRIQVQATTVKALGHCVSRLPS---LTRLGMLSWLLDEE DMKVINDVKERHPQSKRLTIF----------------------------------WKWIV PFSPVVLE--- >D_melanogaster_FBpp0075254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MASVVA-DLPSYGPIAFDQVDNNTNATQLFKNNINKTRMND LNREETRLKTFTD-------WPLD---WLDKRQLAQTGMY---FT----HAGDKVKCFFC GVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGANDST LEMREHAY-------------------------AEGVIPMSQLIQSIGMNAVNAAGSVTG TAA-PQPRVTVATHASTATQATGDVQPETCRPSAASGNYFPQ---YPEY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AIETA RLRTF------------------------------------------------------- ---------------------------E---AWPR-NLKQKPHQLAEAGFFY-TGVGD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVRCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLMD------------------- ------------------------------------------------------------ -----------------------------------------------------WNDNDEP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LW---------------------- -----------LS--QC---RFVKLM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QLYIDTVAAKPVL-AEEKEESSSIGGVA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VASTQASEEEQQTSLSSEEAV-- -SGDVAPSVAPTAATRIFNKIVEATAVATP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------STN--SSG----- ------------------------------------------------------------ -------------------STSIP------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- --------------------------LC-------------------------------- ------------------------------KICYG------------------------- ------------------------AEYNTAFLP-----------------CGHVV----- -ACAKC------------------------------------------------------ ---------------------------ASSVTKCPLCRKPFTD---VMRVYF-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000000487 ----------------------------------------------------------M- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SIE LFKEENRRETFKT-------WSAAF-NDEFVKELARSGFF---YL----GNLDRTQCFSC SGVLRNWRASDDVNVEHFRHFPHCKMGSNSESKN-----VPLPLDHPIDVDDIPEPPDPS PKEQENLV-------------------------KMFTL---------------------- --------------------------------------GAPM---NPHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RSLDA RVATF------------------------------------------------------- --------------------------DR---RWPARKVKASATHIAKAGFYF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RAKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDANDEP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---EFVLRN-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAFVHEIYTNNPN-LNRP--EIQNARSEYLTSPKKNGG---------------------- ------------------------------------------------------------ ---------------------------------------VMISQ---------------- ------------TATITAGDVLANYLPPPPPDGVERSPETGSATD--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VD--------AMM KNEVV---S--------------------------------------------------- ------------------------------------------------------------ ------------VVTSMGFGHDLIRKAVE------------------------------- ------------------------------------------------------KH--IS NNGSNPP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TTEGL----------------LELILQ--LDENDD----VIADDV-- -INGDVMQDDIGA----------------------------------------------- -----------------------------------IGGIVISQGEGVETKSSLKRNND-- ------------------------------------------------------------ ------------------------------------------------------------ -KAEQDSDQKP----------MKQQKFD-------------------TNA--FEE----- ------------------------------------------------------------ -------------------LESLE------------------------------------ ----------------------------------------------------------ME R----------------------------------------------------------- --------------------------RC-------------------------------- ------------------------------RACRN------------------------- ------------------------HVADTVVMP-----------------CGHLC----- -FCSSC------------------------------------------------------ ---------------------------SSSSKRCGLCREKIQS---VMKVYL-------- ---------S-------------------------------------------------- ----------- >M_musculus_ENSMUSP00000022142 MAEHGESSEDRISEIDYEFLPELSALLGVDAVQLAKSQEEEEHKERMKMKKGFNSQMRSE AKRLK---------TFETYDTFRSWT-PQEMAAAGFY-------------HTGVKLGVQC FCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKML-------- ------------------------------------------------------RGGKAR YHEEEARLESFED-------WPFYA-HGTSPRVLSAAGFV---FT----GKRDTVQCFSC GGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQGYEGFVHVTGEHFVNSWVR RELPMVS----------------------------------------------------- --------------------------------------AYC---NDSVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ANEEL RMDTF------------------------------------------------------- ---------------------------K---DWPH-ESPVAVDALVRAGLFY-TGKKG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCMEK------------------- ------------------------------------------------------------ -----------------------------------------------------CTEGDDP IQEHN------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--NC---VFLQTP-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPALQSHCA-LPEAMETTSESNHDDPAAVHSTVV---------------------- ----------------------GLGRSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVC SSLGTD-HLIGCDVSIISKHISQPVQGALTIPEVFSNLSSVMCVEGETGSGKTTFLKRIA FLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLGAGGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISEVCLSSIIQQL QHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNRVRGIRSYLDTSLEIKEF PLSNTVYILKKFFSHNIKRLLEFMVYFGQNEDLQGIHKTPLFVAAVCTDWFENPSDQ-PF QDMALFKSYMQYLSLKHKGAAKPLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDE ELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAMRLTELLSSDRQEDQDLGLYYLRQ--IN SPLKALT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TYNNFLKYVFSHPSSKAGPTVVSHLLHLVDETELLENTYKNEDYV-- -NHPPGTSRIMK-GLKELWLLSPEYYSSFVSEHLLRI----------------------- -----------------------ALNFAYESNTVAECSPFILQFLRGRTLALKVLNLQ-- ----YFRDHPESLLLVKSLEVSINGNKVPKVVDYSVMEKSFETLQPPTIDQDYASAFEQM KEHEKNLSENEETIKSIKNIFPLQPPKISSGYWKLSPKPCKIPRLEVGVTNMGPADQALL QVLMEVFSASQSIEFRLSDSSGFLESIRPALELSKASVTKCSMSRLELSRAEQEL----- ------------------------------------------------------------ -------------------LLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCVRLDG KPDVLSVLPGEFPNLLHMEKLSI-RTSMESDLSKLVKLIQNSPNLHVFHLKCDFLSNCDS LM---------------------------------------------------------- ----------------------AVLASC-------------------------------- ------------------------------KKLREIEFSGRCFEAMPFVNILPNFISLKI LNLISQQFPDKETSEKFAQALGSLRNLEELLVP-----------------TGDGIHQVAK LIVRQCLQLPCLRVLAFHYILDNDSVIEIARVATS-GGFQKLEKLDLSMNHKITEEGYRN FFQALDNLPNLQNLNICRHIPECIQVQATTVKALGQCVSRLPS---LTRLHMLSWLLDEE DMKVINDVKERHPQSKRLIIF----------------------------------WKWIV PFSPVVLE--- >X_tropicalis_ENSXETP00000016315 ------------------------------------------------------------ --------------------KHFPYQTSDKLAWAGFF-------------YVGPGDRVRC FSCGGEVDNWEPGDVPLTRHQLFFPHCSYVQGLSIRHSYFM------------------- ---------------------------------------EEGVGPGFLDTN--ILGKEGD MSDEYSRIQSYQA-------VKEHF-PNQTPIKLAWAGFY---YV----GPKEKVRCFSC GGEMDEWWSREDPLTEHHRRFPQCHFILGRKEGN--------------PPGKG------- ------------------------------------------------------------ --------------------------------------SLPS---PRIF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LCPRK CLEAQ------------------------------------------------------- ---------------------------L---DFPCLLHHQTPIKLAWAGFYY-VGPKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGEMDK------------------- ------------------------------------------------------------ -----------------------------------------------------WWSREDP LTEHH------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RR---------------------- -----------FP--QC---HFILGR-KA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VSNDPYTMTE-MLKGLNNQQSQPT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000113890 MAAQGEAVEEIICEFDDDLVSELSTLLRVDALSVLKRQQEEDHKTRMKMKKGFNSQMRSE AKRLK---------TFETYDKFRSWT-PQEMAAAGFY-------------HTGVKLGVQC FCCSLILFSTRLRKLPIENHKKLRPECEFLLGKDVGNIGKYDIRVKSPEKML-------- ------------------------------------------------------RGDKAR YHEEEARLESFED-------WPFYA-HGTSPRVLSAAGFV---FT----GKRDTVQCFSC GGCLGNWEEGDDPWKEHAKWFPKCEFLQSKKSPEEITQYVQSYEGFLHVTGEHFVNSWVR RELPMVS----------------------------------------------------- --------------------------------------AYC---NDSVF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ANEEL RMDTF------------------------------------------------------- ---------------------------K---DWPH-ESPGAVEALVKAGLFY-TGKRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCMEK------------------- ------------------------------------------------------------ -----------------------------------------------------WAEGDNP IEDHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KF---------------------- -----------FP--NC---VFLQTL-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPALQSHCA-LPEAMETTSESNHDDAAAVHSTVVDVSPSEAQELEPASSLVSVLCR DQDHSEAQGRGCASSGTYLPSTDLGQSEAQWLQEARSLSEQLRDTYTKATFRHMNLPEVY SSLGTD-HLLSCDVSIISKHISQPVQGSLTIPEVFSNLNSVMCVEGEAGSGKTTFLKRIA FLWASGCCPLLYRFQLVFYLSLSSITPGQELAKIICAQLLGAGGC--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ISEVCLSSIIQQL QHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNKVRGIRPYLDTSLEIKEF PFYNTVSVLRKLFSHDIMRVRKFINYFGFHEELQGIHKTPLFVAAVCTDWFKNPSDQ-PF QDVALFKAYMQYLSLKHKGAAKPLQATVSSCGQLALTGLFSSCFEFNSDNLAEAGVDEDE ELTTCLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQ--IN SPLKAMS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------IYHTFLKYVSSHPSSKAAPTVVSHLLQLVDEKESLENMSENEDYM-- -KLHPEALLWIE-CLRGLWQLSPESFSLFISENLLRI----------------------- -----------------------CLNFAHESNTVAACSPVILQFLRGRTLDLKVLSLQ-- ----YFWDHPETLLLLKSIKISLNGNNWVQRIDFSLIEKSFEKVQPPTIDQDYAIAFQPI NEVQKNLSEKKHIIKKYEDMKHQIPLNISTGYWKLSPKPYKIPKLEVQVTNTGPADQALL QVLMEVFSASQSIEFRLSDSSGFLESIRPALELSKASVTKCSMSRLELSREDQKL----- ------------------------------------------------------------ -------------------LLTLPTLQSLEVSETNQLPDQLFHNLHKFLGLKELCVRLDS KPDVLSVLPGEFPNLHHMEKLSI-RTSTESDLSKLVKLIQNSPNLHVFHLKCNFLSNCEP LM---------------------------------------------------------- ----------------------TVLASC-------------------------------- ------------------------------KKLREIEFSGRCFEAMTFVNILPNFVFLKI LNLRDQQFPDKETSEKFAQALGSLRNLEKLFVP-----------------TGDGIHQVAK LIVRQCLQLPCLRVLVFAETLDDDSVLEIAKGATR-GGFQKLENLDLTLNHKITEEGYRN FFQVLDNLPNLKNLDISRHIPECIQIQAITVKALGQCVSRLPS---LTRLGMLSWLLDEE DIKVINDVKERHPQSKRLTVH----------------------------------WRWVV PFSPVIQK--- >C_intestinalis_ENSCINP00000011648 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MAAAGLFY-IGQTD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WLPNDDP WFEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TC---EYVLQQ-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PEYVHNVCMQFPN-LRRPDLPLRNLPSV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------VSGPSHQTPGGGLLYHQSPQIIDPREETRRR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------KAKIDREMI ASPLV---N--------------------------------------------------- ------------------------------------------------------------ ------------QARQLGFSNNQIRSAFT------------------------------- ------------------------------------------------------KS--FE VSDKTCE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NMDEL----------------IDIISNLPNDDHDQARGSNEQTTS-- -YQYSSTAT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LSR--AEE----- ------------------------------------------------------------ -------------------IRAIE------------------------------------ ----------------------------------------------------------ES K----------------------------------------------------------- --------------------------IC-------------------------------- ------------------------------KVCRN------------------------- ------------------------ANACIVLLP-----------------CGHLS----- -VCQGC------------------------------------------------------ ---------------------------SVNIERCPICRTFTRE---KLLTYL-------- ---------V-------------------------------------------------- ----------- >G_gorilla_ENSGGOP00000008152 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------M----GPKDSAKCLHR GPQPSHWAAGDGPTQERGGPRSLGSPVLGLDTCR---------AWDHVDGQILGQLRPLT EEEEEEGAGATLS----------------------------------------------- --------------------------------------RGPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------Y---DWPL-TAEVPPELLAAAGFFH-TGHQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WKRGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--SC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSVQETHSQ-LLGSWDPWEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--VA PSVPASG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------YPELPT--PRREVQ----SESAQE-- -PGGVSPAQAQRAWWVLEPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--RDV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSIVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APSLQLCPICRAPVRS---RVRTFL-------- ---------S-------------------------------------------------- ----------- >P_pygmaeus_ENSPPYP00000012543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------M----GPKDSAKCLHC GPQPSHWAAGDGPAQEHCGPRSLGSPVLGLDTCR---------AWDHVDGQILGQLRPLA EEEEEEGAGATLS----------------------------------------------- --------------------------------------RGPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------Y---DWPL-TAEVPPELLAAAGFFH-TGQQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WKRGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--SC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSVQETHSL-LLGSWDPWEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--AA PSVPASG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DPELPT--HRREVQ----SESAQE-- -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--RDV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------RC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSIVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APSLQLCPICRAPVRS---RVRTFL-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000010449 ------------------------------------------------------------ --------------------------------------------------MQARMMDIRC DGLRVVHNDGRLVPSATNSERE-------------------------------------- -----------------------------------------------------LYTRPGD PYYESYRLATFTN-------YPNQ---NINVRQVARAGFY---FI----SYQDQVKCFSC GQICEDLQQYDD-MSLPQWHLPDCEHLHSLQPNRNNHANTPVQSGLSRPNENATFRSLPT RRPAHSNV-------------------------HSSSSLPRQPTTITINQPRIRSTFTIH EHSNIDLFPC----------------------------NRPE---SPHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RSVEQ RLQTF------------------------------------------------------- -------------------------TRS---NWPAHRVRASILDISRAGLFY-LGNSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RTKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPNDDP WYEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--EC---EFLLQQ-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IEYVYRVSSQFPN-LQRPVIVRSQPQPS-------------------------------- ------------------------------------------------------------ ------------------------------------------VTIHINRPGRTTMPTAST THTTSSTTRISAPRSTVVSGPQFLPPMIPGPSINIIDPREQPRSR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EEELNRYIT TSPYI------------------------------------------------------- ------------------------------------------------------------ -----------AVARGMGFDDEAIRSTLR------------------------------- ------------------------------------------------------RQ--HE QSQRFFS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SAEEL----------------VDALLNQSNITSAPQIPSSSTAGA-- -TGGP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ITP--LEE----- ------------------------------------------------------------ -------------------LRQLE------------------------------------ ----------------------------------------------------------QS R----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KVCHR------------------------- ------------------------NQANMVLLP-----------------CGHVA----- -CCTTC------------------------------------------------------ ---------------------------GNDVTNCPVCLADITD---RVRSYI-------- ---------G-------------------------------------------------- ----------- >P_pygmaeus_ENSPPYP00000017359 MATQQKASDERISQFDHDLLPELSALLGLDAVQFVKEIEEEEQKERAKMQKGYNSQMRSE AKRLK---------TFVTYEPYSSWI-PQEMAAAGFY-------------FTGVKSGIQC FCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-------- ------------------------------------------------------RGGKMR YQEEEARLASFKN-------WPFYV-QGIPPCVLSEAGFV---FT----GKQDTVQCFSC GGCLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEITQYIQSYQGFVDITGEHFVNSWVQ RELPMAS----------------------------------------------------- --------------------------------------AYC---NDSIF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AYEEL RLDSF------------------------------------------------------- ---------------------------K---DWPR-ESAVGVAALAKAGLFY-TGIKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IFQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCLEK------------------- ------------------------------------------------------------ -----------------------------------------------------WQEGDDP LDNHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RC---------------------- -----------FP--NC---PFLQNM-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVIPDLQSHGE-LCELLETTSESNPEDSIAVDPIVP---------------------- ----------------------EMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDIS SDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIA FLWASGCCPLLNRFQLVFYLSFSSTRPDQGLASIICDQLLEKEGS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTEMCMRNILQQL KNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRACLLIAVRTDKARDIRRYLETILEIKAF PFYNTVFILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SF DDVAVFKSYMERLFLRNKATAELLKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDE DLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLESDRQEHQDLGLYHLKQ--IN SPMMTVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYL-- -KHQPEISLKMQ-LLRGLWQICPQAYFSMVSEHLLVL----------------------- -----------------------ALKIAYQSNTVAVCSPFVLQFLQGRTLTLGALNLQ-- ----YFFDHPESLSLLRSIHFSIQGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPM NEWERNLAEKEDDVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLKVNVNDIDAVDHEML EILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQEL----- ------------------------------------------------------------ -------------------LLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEG KINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFES LM---------------------------------------------------------- ----------------------TILASC-------------------------------- ------------------------------KKLTEIKFLDSFFQPVPFVAILPNFISLKI LNLEGQQFPDDETSEKFAYILGSLSNLEELILP-----------------TGDGIYRVAK LIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAIN-GGFQKLENLKLSINHKITEEGYRN FFQALDNMPNLQELDISRHFTEVIKTHATTVKSLSQCVLRLPR---LIRLNMLSWLLDAD DIALLNVMKERHPQSKYLNIL----------------------------------QKWIL PFSPIIQK--- >H_sapiens_ENSP00000194097 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE AKRLK---------TFVTYEPYSSWI-PQEMAAAGFY-------------FTGVKSGIQC FCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-------- ------------------------------------------------------RGGKMR YQEEEARLASFRN-------WPFYV-QGISPCVLSEAGFV---FT----GKQDTVQCFSC GGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQ RELPMAS----------------------------------------------------- --------------------------------------AYC---NDSIF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AYEEL RLDSF------------------------------------------------------- ---------------------------K---DWPR-ESAVGVAALAKAGLFY-TGIKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCLEK------------------- ------------------------------------------------------------ -----------------------------------------------------WQEGDDP LDDHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RC---------------------- -----------FP--NC---PFLQNM-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAEVTPDLQSRGE-LCELLETTSESNLEDSIAVGPIVP---------------------- ----------------------EMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMSLLDIS SDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIA FLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTEMCVRNIIQQL KNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIKAF PFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SF DDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDE DLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQ--IN SPMMTVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYL-- -KHQPEISLQMQ-LLRGLWQICPQAYFSMVSEHLLVL----------------------- -----------------------ALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNLQ-- ----YFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPM NEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDML EILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQEL----- ------------------------------------------------------------ -------------------LLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEG NINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGS LM---------------------------------------------------------- ----------------------TMLVSC-------------------------------- ------------------------------KKLTEIKFSDSFFQAVPFVASLPNFISLKI LNLEGQQFPDEETSEKFAYILGSLSNLEELILP-----------------TGDGIYRVAK LIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAIS-GGFQKLENLKLSINHKITEEGYRN FFQALDNMPNLQELDISRHFTECIKAQATTVKSLSQCVLRLPR---LIRLNMLSWLLDAD DIALLNVMKERHPQSKYLTIL----------------------------------QKWIL PFSPIIQK--- >P_troglodytes_ENSPTRP00000048273 MATQQKASDERISQFDHNLLPELSALLGLDAGQLAKELEEKEQKERAKMQKGYNSQMRSE AKRLK---------TFVTYEPYSSWI-PQEMAASGFY-------------FTGVKSGIQC FCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRL-------- ------------------------------------------------------RGGKMR YQEEEARLASFRN-------WPFYV-QGISPCVLSEAGFV---FT----GKQDTVQCFSC GGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVH RELPMAS----------------------------------------------------- --------------------------------------AYC---NDSIF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AYEEL RLDSF------------------------------------------------------- ---------------------------K---DWPR-ESAVGVAALAKAGLFY-TGIKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGCLEK------------------- ------------------------------------------------------------ -----------------------------------------------------WQEGDDP LDDHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RW---------------------- -----------FP--NC---PFLQNM-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SVEVTPDLQSRGE-PCELLETTSESNLEDSIAVDHIVP---------------------- ----------------------EMAQGEARWFQEAKNLNEQLRAAYTSASFRHMSLLDIS SDLATD-HLLGCDLSIASKHISKPVQEPLVLPEVFANLNSVMCVEGEAGSGKTVLLKKIA FLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTEMCMRNIIQQL KNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTDRARDIRRYLETILEIKAF PFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDP-SF DDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDE DLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQ--IN SPMMTVS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYL-- -KHQPEISLQMQ-LLRGLWQICPQAYFSMVSEHLLVL----------------------- -----------------------ALKIAYQSNTVAACSPFVLQFLQGRTLTLGVLNLQ-- ----YFFDHPESLSLLRSIHFSIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPM NEWERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVNVNDIDVVGQDML EILMTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQEL----- ------------------------------------------------------------ -------------------LLTLPSLESLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEG NINVFSVIPEEFPNFHHMEKLLI-QISAEYDPSKLVKLIQNSPNLHVFHLKCNFFSDFES LM---------------------------------------------------------- ----------------------TMLVSC-------------------------------- ------------------------------KKLTEIKFLDSFFQAVPFVASLPNFISLKI LNLEGQQFPDEETSEKFAYILGSLSNLEELILP-----------------TGDGIYRVAK LIIQQCQQLHCLRVLSFFKTLNDDSVVEIAKVAIS-GGFQKLENLKLSINHKITEEGYRN FFQALDNMPNLKELDISRHFTECIKAQATTVKSLSQCVLRLPR---LIRLNMLSWLLDAD DIALLNVMKERHPQSKYLTIL----------------------------------QKWIL PFSPIIQK--- >H_sapiens_ENSP00000217169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------M----GPKDSAKCLHR GPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCR---------AWDHVDGQILGQLRPLT EEEEEEGAGATLS----------------------------------------------- --------------------------------------RGPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------Y---DWPL-TAEVPPELLAAAGFFH-TGHQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WKRGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--SC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSVQETHSQ-LLGSWDPWEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--VA PSVPASG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------YPELPT--PRREVQ----SESAQE-- -PGGVSPAEAQRAWWVLEPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--RDV--EAQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSIVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APGLQLCPICRAPVRS---RVRTFL-------- ---------S-------------------------------------------------- ----------- >M_mulatta_ENSMMUP00000012096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------M----GPEDSAKCPRH GPQLCRWAAGDGPARERCGPRSLGSPALGLDSCR---------AWDHVDGQILGQLRPLA EEEEEEGAGAMSP----------------------------------------------- --------------------------------------RGPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------Y---DWPL-TAGVPPELLAAAGFFH-TGQQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WKRGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--SC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSVQETHSQ-LLGSWDPWEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--VA PSVPAPG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DPELPT--PRREVQ----SESAQE-- -PGGASPAQAQSGWWVLEPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--RDV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSIVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APSLQLCPICRAPVRS---RVRTFL-------- ---------S-------------------------------------------------- ----------- >P_troglodytes_ENSPTRP00000023641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LGLDTCR---------AWDHVDGQILGQLRPLT EEEEEEGAGATLS----------------------------------------------- --------------------------------------RGPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------Y---DWPL-TAEVPPELLAAAGFFH-TGHQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------HGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WKRGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--SC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSVQETHSQ-LLGSWDPWEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--VA PSVPASG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------YPELPT--PRREVQ----SESAQE-- -PGGVSPAQAQRAWWVLEPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--GDV--EAQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------HAVSIVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APGLQLCPICRAPVRS---HVRTFL-------- ---------S-------------------------------------------------- ----------- >E_caballus_ENSECAP00000002314 MATEEKAPAGRDSRFDHALLQELSALLGIDAVQYAKEMEEEEQREREKMQQGFNSRMRSE AKRLK---------TFATYEAYSSWT-PQEMAAAGFH-------------FTGVRAGVQC FCCGLILFGASLHKRPLDDHKRLRPDCGFLLGEDVGNVAKYEVRVRKPPGTL-------- ------------------------------------------------------RGDAAR YREEEARLKSFKD-------WPFYA-QATAPRELSAAGFV---FT----GSRDAAQCFSC GGCLGNWEDGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQSYEGFVGVTGEHFLNSWVK RVVPMVS----------------------------------------------------- --------------------------------------AYS---SDSIF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ANGEL RLDSF------------------------------------------------------- ---------------------------K---NWPP-ASPVGAAALAKAGLFY-TGVKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GVCLEN------------------- ------------------------------------------------------------ -----------------------------------------------------WKEGDDP VEDHT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KY---------------------- -----------SP--NC---QFLQNM-KS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SAGATPDLQSRDV-IPSPTKSTCESNLADSAAVSSPAP---------------------- ----------------------EMAQGEAQWFQEAKGLSERLRKAYTSARFCNTSLLEVA PCLATD-QLLGCDLSLASKRIGSHVQEPVVLPEVFATLNSVMCVEGEAGSGKTVLLKRIA LLWASGGCPLLNRFQLVFYVSLSSARPDQGLASILCDQLLETEDS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTEMSLRPIIQQL KNQVLFLLDDFREMCSVPRVIEKLIQRNHSSRTCLLIGVRRSRARAIHRHLHTILEIKAF PFYNSIYILRKLFSHNMIRLRNFMIHFGKNKNLQGIQKTPLFVVAVCAHWFRHPLDQ-SF DDVAVFKSYMECLFLKYKTTADLLRATVSSCGELALKGFFSSCFEFRDDDLVEAGVDQDE DLAMCLMSKSTAQRLRPVYQFLSPAFQEFLAGMRLTELLDSDRQEDRELGLHYLRE--VN SSLMAVI----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PYSNFFNYVSCHASTKAGPKVVSHLLRLVDKKESLENILESDDYL-- -KHRPEISVHME-YFRVLWQLSPKYYFSQVSEHLLAL----------------------- -----------------------AIKIAYQSNALAACSPFILRFLQGRTLTFNMLKSQ-- ----YFFDHPESLLLLRSIQFSIKGRKSS-RLDLSVLETCLDKSQAPTIDQDYASAFEPA KEWEQNLAEKEENVKSFLDMQLNAPPDISTGYWKLSPKPYKIPLLEVHVTDIDAVDQEML RVLTAVFSASQHIELHLNDSRGFLESVRPALEQYKASFTKCSISRFELSAADQEL----- ------------------------------------------------------------ -------------------LLTLTSLESLEVSGTTWLRDQLFPNLDKFLCLKELSVDLDD KQNVFSVIPEDFVNLHHMEKLLI-RIAAEHGPSKLVRLIQNSPDLQVFHLQCNFFSDFES LM---------------------------------------------------------- ----------------------TVLASC-------------------------------- ------------------------------KKLKEIKFSGRFFKAIPFVIVLPNFTSLKM LNLGHQEFPDRETAEKFAYTLGSLDNLEELILP-----------------TGDAVHQVAK LIVQQCEHLRGLRVLSFYQTLNDDSLMEIVRALTSGGGFQKLENLNLSINHKITEEGYRN FFQALDSLPRLQELTISRHFTECIKAQAATVKSLSQCVSRLPS---LIRLNMLSWLLDAE DVTLLTAMKERHPQSKHLTFH----------------------------------WKWIL PFSPIIQK--- >A_aegypti_AAEL009074-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MAG-VMMAQVLSTPRDFTDNKVKEDNAYGHTATSVPIS YHTEVARLESFRG-------WMVS---FISKTELARYGFY---YV----GPNDMVKCYFC RVEIGLWEPNDNVLSEHLRWSPYCPLLRKRQTNNVPIDASFLDQLPEPSYDTCGIRIREN SVAENAYSSSDRSSS------------------GSLTSPPSSLTSESSMASNGPVVQQLS APVLPQQ-------------------------------KLPE---YPNY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AIEAK RLESY------------------------------------------------------- ---------------------------E---DWPK-FMKQKPKELSDAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLKD------------------- ------------------------------------------------------------ -----------------------------------------------------WEAEDEP WEQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MW---------------------- -----------YS--NC---EYLKLM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EAYIAHCLAKKES-SSEENGSDVGPSNS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PQ PSTSGVV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SAATSSLQSSQSSSLSVSAEEDNT-- -AMVGCS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SDE--DEP----- ------------------------------------------------------------ -------------------NRKLD------------------------------------ ----------------------------------------------------------TS R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KICYV------------------------- ------------------------NEYNTAFSP-----------------CGHVV----- -ACAKC------------------------------------------------------ ---------------------------ASSVTKCPLCRKPFTN---VMRIYL-------- ---------M-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000000510 ----------------------------------------------------------M- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SIE LFKEENRRETFKT-------WSAAF-NDEFVKELARSGFF---YL----GNLDRTQCFSC SGVLRNWRASDDVNVEHFRHFPHCKMGSNSESKN-----VPLPLDHPIDVDDIPVPPDPS PKEQEDLV-------------------------KMFTL---------------------- --------------------------------------GAPM---NPHM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RSLDA RVATF------------------------------------------------------- --------------------------DR---RWPARKVKASATHIAKAGFYF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RAKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDANDEP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--GC---EFVLRN-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ISFVHEIYTNNPN-LNRP--EIQNARSEYLTSPKKNGG---------------------- ------------------------------------------------------------ ---------------------------------------VMISQ---------------- ------------TATITAGEVLANYLPPPPPDGVERSPETGSATD--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VD--------AMM KNEVV---S--------------------------------------------------- ------------------------------------------------------------ ------------VVTSMGFGHDLIRKAVE------------------------------- ------------------------------------------------------KH--IS NNGSNPP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TTEGL----------------LELILQ--LDENHD----VIADDV-- -INGDVMQDDIGA----------------------------------------------- -----------------------------------IGGIVISQGEGVETKSSLKRNND-- ------------------------------------------------------------ ------------------------------------------------------------ -KAEQDSDQKP----------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >A_gambiae_AGAP007294-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------M-AHALSLPAPPIDLPDNKHKDDDL----ACMSPEY FHIEENRLRSFTSR------WPVT---FISPNVLARYGFY---YV----GTDDTVKCYFC RVEIGLWEPQDDVIQEHLRWSPYCPLLKKRPTNNVPLNANYLDAVPEPSFDTCGISVRHN SLM--------------------------------------------------------- --------------------------------------RRPE---YPNY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AIEAD RLKSY------------------------------------------------------- ---------------------------E---DWPT-SLKQKPQQLSDAGFFY-TGMSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGLKD------------------- ------------------------------------------------------------ -----------------------------------------------------WEQEDDP WQQHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------IW---------------------- -----------YS--NC---HYLQLM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ REFIQKCNELKEA-ASASS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------AASTSSAMSSASSQPSTDEGEDDA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GGD----- ------------------------------------------------------------ -------------------RRVPS------------------------------------ ----------------------------------------------------------DG K----------------------------------------------------------- --------------------------IC-------------------------------- ------------------------------KICFV------------------------- ------------------------NEYNTAFMP-----------------CGHVV----- -ACAKC------------------------------------------------------ ---------------------------ASSVSKCPLCQQPFIN---VLRLYL-------- ---------S-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000034890 ------------------------------------------------------------ --------------------KHFPYMKEWDLAQAGFY-------------YVGPGDRVRC ISCNAELEKWEKWDEPLTRHQHSFPDCAYVQEQRAQTTGTQDQSQVCPM----------- ----------------------------------PIKEGESGIPARYSGSHNPGEKPLGD MNDEYSRLETYRG-------HSQYF-PMANQRRLAQAGFS---YV----GPGDQVRCFSC GGELEKWERWDVPLTRHQHSFPHCHYIYGRKTGY-------IGIPLLRPLGEV------- ------------------------------------------------------------ --------------------------------------SETQ------L----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LYGRR SWTGF------------------------------------------------------- ---------------------------S---GHQHPREDQTPIKLAWAGFYY-VGPKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGEMDE------------------- ------------------------------------------------------------ -----------------------------------------------------WWSREDP LTEHH------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RK---------------------- -----------FP--QC---HFILGR-KA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VSNDPYTMTE-MLKGLNNQQSQPT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >X_tropicalis_ENSXETP00000016312 ------------------------------------------YSGSQNPGEKPLGDMNDE YSRLE---------TYRGHSQYFPMANQRKLAQAGFS-------------YVGPGDRVRC ISCGGELEKWERWDVPLTRHQHSFPHCPYMQKLRDEGDGKENQSKVCAG----------- ----------------------------------PIKEGESGTTVPLSSSSNLEKKPCGY MSDEYSRLESYRGHGQHFNYWNQQRLAKQTSDELAWAGFF---YV----GPGDRVRCFSC GGEVDNWEPGDVPLTGHQLFFPHCSYVQGLSIRHSYFMEEGVGPGFLDT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NILGN RIQSY------------------------------------------------------- ---------------------------Q---AVKEHFPNQTPIKLAWAGFYY-VGPKD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGEMDK------------------- ------------------------------------------------------------ -----------------------------------------------------WWSREDP LTEHH------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RR---------------------- -----------FP--QC---HFILGR-KA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VSNDPYTMTE-MLKGLNNQQSQPT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >G_gorilla_ENSGGOP00000005705 ----------------------------MNIVEN-SIFLSNLMKSAN-TFEL-KYDLSCE LYRMS---------TYSTFPAGVPVS-ERSLARAGFY-------------YTGVNDKVKC FCCGLMLDNWKRGDSPIEKHKKLYPSCRFVQSLNSV--NNLEATSQPTFPSSVTNS---- -----------THS-LLPGTENSGY-FSGSXSN-SPSNPVNSRANQDFSALM-RSSYHCA MNNENARLLTFQT-------WPLT---FLSPTDLAKAGFY---YI----GPGDRVACFXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------XX--- ------------------------------------------------------------ --------------------------------------XXXX---XXXX----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------XXXXX XXXXX------------------------------------------------------- ---------------------------X---XXXX-XXXXXXXXXXXXXXXX-XXXXX-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------XXXXXXX--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------XXXXXX------------------- ------------------------------------------------------------ -----------------------------------------------------XXXXXXX XXXXX------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------XX---------------------- -----------XX--XC---EYLIRI-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFIRQVQASYPH-LLEQ--XXXXXXXX-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------XXXXXXXX--XIHFEPGEDHSED--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AI--------M-M NTPVV---N--------------------------------------------------- ------------------------------------------------------------ ------------AAVEMGFSRSLVKQTVQ------------------------------- ------------------------------------------------------RK--IL ATGENYR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LVNDL----------------VLDLLN--AEDEIR----EEERER-- -AXXXXXX--XXXXXXXXXX---XXXXXXXXX-XXXX----------------------- -----------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-- ------------------------------------------------------------ ------------------------------------------------------------ -XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XX--LPV--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCKDC------------------------------------------------------ ---------------------------APSLRKCPICRSTIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >A_carolinensis_ENSACAP00000005440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------QPE---YPDL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AMERD RLRTY------------------------------------------------------- ---------------------------D---SWPS-DAQVSPEELAGAGFFY-TGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------YVLCFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGALRN------------------- ------------------------------------------------------------ -----------------------------------------------------WERGDDP WMEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RW---------------------- -----------FP--RC---EFLLQS-RG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFINSIQDSYFS-TLVSKVVLKDPFPK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------TG--MT EKQNPCG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------NVEIIP--CSREVE----TEQPNQ-- -PDST------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LST--EEK----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------MC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KDVSIVLVP-----------------CGHLV----- -VCSEC------------------------------------------------------ ---------------------------APNL----------------------------- ------------------------------------------------------------ ----------- >M_musculus_ENSMUSP00000104503 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MFSPADLFRAAVF---SM----GPESRARDSVR GPELSHREDGSGRTQEQDKPHCPCNHVLGQ---------------DCLDGQILGQLRPLS EEEESSGAAFL------------------------------------------------- --------------------------------------GEPA---FPEM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DSEDL RLASF------------------------------------------------------- ---------------------------Y---DWPS-TAGIQPEPLAAAGFFH-TGQQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WERGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RW---------------------- -----------FP--RC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVERIQTYTP--LLGSWDQREEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------VS--AT PSAPAHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SPELLR--SRRETQ----PEDVSE-- -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--KDV--QEQ----- ------------------------------------------------------------ -------------------LRQLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------RC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSIVFVP-----------------CGHF------ -VCTEC------------------------------------------------------ ---------------------------APNLQLCPICRVPICS---CVRTFL-------- ---------S-------------------------------------------------- ----------- >C_familiaris_ENSCAFP00000018803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------M----GPEDRAKCWCR GPELGRGRLSPCGHTEGRDGRC-ARCWGGR---------------DRVDGQILGQLRPLA EEEEAGEPRAGP------------------------------------------------ --------------------------------------PRPA---FPGM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEQL RLASF------------------------------------------------------- ---------------------------S---AWPL-TAVVQPELLAAAGFFH-TGQQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WEQGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLLQT-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVCSVQEACCH-LLGSWDPSEEPEDT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--AT PSAPVHM----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SPELPT--PRREVQ----SEGARE-- -PGKGVEPRPRGCCWVLEPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--RDA--EEQ----- ------------------------------------------------------------ -------------------LQRLR------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------VC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RTVCTVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APALQLCPVCRAPIRS---CVRTFL-------- ---------P-------------------------------------------------- ----------- >A_carolinensis_ENSACAP00000009897 ------------------------------------------------------------ ----------------------STWA-PLEMAAAGFY-------------HTGTKTAIQC FCCGLVLLARSIKRSPYVEHKKYWSQCAFILGKEVGNIPKYEIRVLYPR----------- -----------------------------------------------------RRYSGVT YKHLESRLQSFAD-------WPSYA-REAQPDLLAKAGFF---FT----GIKDTVQCFAC SGCLGNWEDGDDPWKEHAKWFPECEFLQKEKTRDEIKEYIQNYCAFVGLTVSFFAFTLLI YLVPKGD----------------------------------------------------- --------------------------------------LELA---INIY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EDEGC RLDSF------------------------------------------------------- ---------------------------Q---TWPA-EARVDATSLAKAGFFY-TGKMD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVQCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AGCLAE------------------- ------------------------------------------------------------ -----------------------------------------------------WKGDDDP WEGHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KA---------------------- -----------FPQEEC---DFMQNL---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -AKITSMPFQDMK-LCQHSSSFHHISHIFLLSLLTDVA---------------------- -------------------------------FEEHKLLQEQLRRAYDDIHFRKMFPFGDS AHFAIDLKTLFGDLAIVSKNISNLPLQQLTLPEVLENFQFITVVEGEAGSGKTALLRKIA ILWASGCCPILSRYKLVFYLSLNSQNRDLSLVDIICNEVVGLRGV--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LTQEFLETLCKHL KNEILFLLDDYDEMNAVPYDIEDLIQKNYLNKHCLVIAVRTNRIGKIRQYAKTILGITDF PMTSTFYLLRKLFSHNTALVEDFFIQLRVEEAMHSMFKTPLFVVALGTYWTQNPNGS-KF LDLVILKAYMLYTSLKYPQACDRMKATVSACGELALRGLFTSLFEFSEEDLSEVGVSGDD ALWFGLLSKFTAQRLWPIYKFFHLSFQEYFAGLRMNELLSSDVQEDVDRGLQYLQQ--IN TFVKISG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RYQYILRY-ACVEASKAVPQIVTHLLSLPSCEKSFESQIKNDLYL-- -QQTPELKLRQQELLSVTLTLFPEVYLSTFSDFVLEL----------------------- -----------------------VTELAYQSNMTPACAPIISQFLAGKEFSLDHFSSKGG FIRRFFLDYPDTLFLPSRFVMKTIGKEEN--LDMSVEETVYSNLGVPVVDQEYASGFRLF SDVSKQIKEDEDNINKFRTYFPRRFPNSRIVPFLCKRGQEKIPHLQFSAKCINAFQTHDL ENLAVLFSVFSHIDLKLQNCKGLLENIKPAIEQNLEYFKVCSIHNTALNLVEENL----- ------------------------------------------------------------ -------------------LLSMSSLESLEITGKASIPESLFLNLDKYTFLKELSVDLPN CQNLFDIIPEGFKNLHDMEKFIICNIQFGSSSPRLAEFIRNFKKLSVFHLKHCSFSDLGS LM---------------------------------------------------------- ----------------------DAMSSC-------------------------------- ------------------------------KMLTELEIIELPFTDEDHSAALPNFAALKI LNLNGLNFTSKEIGIALGEALAPLENLEELSLP-----------------VGNGMSHAAK LIIQQCSHFPNLRKLEFNQYLSGEGLLEIAKVATD-GGFQKLEVLTLLVNHSITEEFWRR FFESLPQLPKLHDANFGRIFTHPIKCQAATVKSFVQCVSRQQN---LKVINMTGWLFDEK DLQMFDIMKEQHPQSKNLSLF----------------------------------WKWML PVSPIINK--- >E_caballus_ENSECAP00000017749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SM----GPEDKAKCWCR GLELSHQAAGGSPMQGHHRPHCLALSWGGR---------------DHVDGQILGQLHPLA EEEEEGAGAVAAPS---------------------------------------------- --------------------------------------TRPA---FPRM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GSEEL RLASF------------------------------------------------------- ---------------------------C---HWPL-TAVVRPELLAAAGFFH-TGWQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------HGGLQS------------------- ------------------------------------------------------------ -----------------------------------------------------WERGDDP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---EFLLQT-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVCRVQESCCH-QLSSWDQLEEPEDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--SV PSTPVHR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GPDPPM--PRREAQ-----SGARE-- -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GA--QNV--EEQ----- ------------------------------------------------------------ -------------------LQRLR------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------RAVSVVFVP-----------------CGHL------ -VCAEC------------------------------------------------------ ---------------------------APNLQLCPICRAPIDS---CVRTFL-------- ---------S-------------------------------------------------- ----------- >A_gambiae_AGAP007292-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MESHDNTERQERTGLCNELN YNQEINRLRTYFPL------WTVP---YIYPEELARWGFF---YT----GYRDCVRCYFC HIELGGWDEHDVVIEEHLKWSPDCRLMTKRPTDNVPVDANFLDQL-----DTAGTGIPIQ LGTAASRY-------------------------NGPCNRYQPTSSHDNPEWHRQTVLNVS APV-----------------------------------YEPT---IPHY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------EIGDN RLASF------------------------------------------------------- ---------------------------Q---EWPK-CMKQTPEQMADAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVICFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGQLRD------------------- ------------------------------------------------------------ -----------------------------------------------------WLPEYNP WVEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KN---------------------- -----------FS--GC---PYLKLV-KT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PGFIAECQAKWYT-NDVLIGRPEYPGHD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VTK--RKE----- ------------------------------------------------------------ -------------------QHEVA------------------------------------ ----------------------------------------------------------DE N----------------------------------------------------------- --------------------------CC-------------------------------- ------------------------------KICYT------------------------- ------------------------RPFDTVFIP-----------------CGHVV----- -ACGRC------------------------------------------------------ ---------------------------AASTLNCPVCNKWYTS---VQRILF-------- ---------T-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000020067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MAEIDRQDITGLA------SP-----SLTQHKEAKTQILPGRNC----CASNSVTAFDC ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KHPY---TKNM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ENFRE RIRTF------------------------------------------------------- ---------------------------I---SWPRGVTKATPVEIAKAGFFY-LKERD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RAKCFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WEPNDEP WFEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--NC---DFLLRE-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IEFVQNVAGRFPN-LNRP--LLNDQATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KPSTSNLQLPAPATSKQTEVPQNSAS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------HIEITRPTLEEAM ESELV---L--------------------------------------------------- ------------------------------------------------------------ ------------AVSGFGFERELVQLVVE------------------------------- ------------------------------------------------------RL--LQ ETGNVNC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TIMEL----------------VTATQQ--LEQKQM----EENAME-- -VVESFNVN--------------------------------------------------- -------------------------------------------QEKPEMACAQINLST-- ------------------------------------------------------------ ------------------------------------------------------------ -SPTDSFPMQTPGNFTEQQVPGSKKMMYVKQKEVSVPELS---EQSLAQQ--RSQ----- ------------------------------------------------------------ -------------------LQNLK------------------------------------ ----------------------------------------------------------DE M----------------------------------------------------------- --------------------------RC-------------------------------- ------------------------------KICLD------------------------- ------------------------NPMDCILLE-----------------CGHVC----- -TCLEC------------------------------------------------------ ---------------------------SQGIRTCPICRQKITK---IMKIYR-------- ---------NY------------------------------------------------- ----------- >A_gambiae_AGAP007293-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASAVVSCICREIAEYRVTHDTPEEC LNYEVNRLRTFPL-------WTVP---YIYPEELARWGFF---YT----GYRDCVRCYFC RIELGGWDEHDVVIEEHLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSA WSAAATAA-------------------------VAVAMESNRLNRQNELERQSQRTQNDT IPF-----------------------------------YRQK---YPEY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RIGGD RLATF------------------------------------------------------- ---------------------------K---EWPK-SIPQTPTQMADAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVACYYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGNLRD------------------- ------------------------------------------------------------ -----------------------------------------------------WLAEDDP WVEHV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RN---------------------- -----------FS--EC---PYVKLV-KT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PEFIAECRGEKVT-NSALIASSERSGHG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NVSK--DKE----- ------------------------------------------------------------ -------------------QDEVS------------------------------------ ----------------------------------------------------------DE K----------------------------------------------------------- --------------------------CC-------------------------------- ------------------------------KICYI------------------------- ------------------------RPFDTVFIP-----------------CGHVV----- -ACGKC------------------------------------------------------ ---------------------------AASTTKCPMCNESYTS---VQRIFL-------- ---------S-------------------------------------------------- ----------- >X_tropicalis_ENSXETP00000057704 ------------------------------------------------------------ ---------------------------QNKLANAGFY-------------YVGPEDRVRC FSCGGQFEMWEEWDFPLTRHQQTFPECPYLQELKAKGEWKDCHYEPGLGSNILMEK---- --------------PLGDLSDERRR-LETFRGHSGLFPYNRVKFLAIQSPNILGKKSHYD MTNMYSRADTYRG-------HHKHFLPYMKEWDLAQAGFY---YV----GPGDRVRCISC GGELEKWERWDVPLTRHQHSFPHCPYMQKLRDEGDG------------------------ ------------------------------------------------------------ --------------------------------------GTVS---ILYI----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GTNRA WLRQV------------------------------------------------------- --------------------------ST---MWGP-RTGSRENKLANAGFYY-VGPRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVRCFSC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGQLEM------------------- ------------------------------------------------------------ -----------------------------------------------------WEEWDFP LTRHQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QT---------------------- -----------FP--EC---PYLQEL-KA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KGEWQLIMMAQAG-F--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >O_cuniculus_ENSOCUP00000014265 -----MHKTASQRVV------PGTSYRIKSMMED-STISSNTNDQNQ---KM-KYDFSYK I-RVP---------TYSGLPIRVPLS-EWSLAPAGLY-------------YIGMN-KVKC FCCDLMLDNWKQEYNLIEKHKQLYPSCSFSQNLISV---SLESPLRSSF----------- -----------AHP-LFPTQGPCVS-FSGSYPS-LSANPPNLTSV-DFSPLR-TS-LGYS MSTEEAR---FYY-------KPFS---FLLPSEFARAGFS---NV----APGDAVAGFAC DRKQSNWK-KDDAMLE-WRHVPN-PFLEI--------------------------LR--- ------------------------------------------------------------ --------------------------------------FSIS---NWSM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QAH-A QMSTN------------------------------------------------------- ---------------------------M---YWPS-SDPVCPEQLATVDFYY-VALSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DIKCFCC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DGALR-------------------- ------------------------------------------------------------ -----------------------------------------------------FECGDDA -VEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KL---------------------- -----------FA--RC---EFLMGV-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -EFVDEIQDRFPH-LHQQ--LL-TSDPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GEENADPP--IFHFGPGSS-SDD--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------KG--------M-M NTLVV---K--------------------------------------------------- ------------------------------------------------------------ ------------SVLEMSFNISFAKETVH------------------------------- ------------------------------------------------------SK--TL PTRENHK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------ASTLLN--AEDEKR----GEE--R-- -QAEE-----------RANS---MTLFQQLVC-VLPI----------------------- -----------------------LNHLLKVNVINK-ENDIIRQK-QKPLQAIELVDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LLKGIVAANTFKNCLKDIDSMLYKN-FEKKNTKYFPTEDI--SC--PSL--GDQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ -----------------------------------------------------------E V----------------------------------------------------------- --------------------------TF-------------------------------- ------------------------------KMCID------------------------- ------------------------KEVSILFIP-----------------SSNLV----- -VCQAC------------------------------------------------------ ---------------------------AHSLRKYPICRGIIKG---TVCTFL-------- ---------SK------------------------------------------------- ----------- >A_gambiae_AGAP011326-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MSSASGSEVQPA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EMPY---MPEF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AVLDA RIRSF------------------------------------------------------- ---------------------------E---SWRF-GHMQNPTRLAVAGFYY-TGTDD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVRCFQC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DAGLRD------------------- ------------------------------------------------------------ -----------------------------------------------------WLVTDDP WQEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RC---------------------- -----------FA--EC---TFLRLV-FG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ADTVDEVLRNGIA-GFKNGANTATTPSA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TVSGPIDETSSELA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QRL--REE----- ------------------------------------------------------------ -------------------NKRMK------------------------------------ ----------------------------------------------------------QE R----------------------------------------------------------- --------------------------EC-------------------------------- ------------------------------KICLT------------------------- ------------------------QEAEVVFMP-----------------CAHLL----- -SCVQC------------------------------------------------------ ---------------------------STGVDNCPVCRAVITH---RFRAFI-------- ---------C-------------------------------------------------- ----------- >A_gambiae_AGAP007291-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MASTVVSCICREIAEYRVTHIVPEEC LNYEINRLRTYDLL------WTVP---YIYPEELARWGFF---YT----GHRDCVRCYFC RIELGGWDEHDVVIEEHLKWSPHCRLMTKRPTNNVPIDPDFLDQLGEIVPDTTGTGSTSA WSAAATAA-------------------------AA---ESNRLNRQNELE----RTQNDT IPF-----------------------------------YRQK---YPQY----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RIEGD RLATF------------------------------------------------------- ---------------------------K---EWPK-SMPQTPERMADAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVACFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGNLRD------------------- ------------------------------------------------------------ -----------------------------------------------------WLAEDDP WVEHV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RN---------------------- -----------FS--EC---PYVKLV-KT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PEFIAECRGEKVT-NSALTAGPEHSGHG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NVSK--DKE----- ------------------------------------------------------------ -------------------QDEVS------------------------------------ ----------------------------------------------------------DE K----------------------------------------------------------- --------------------------CC-------------------------------- ------------------------------KICFT------------------------- ------------------------RPFDTVFMP-----------------CGHVV----- -ACGRC------------------------------------------------------ ---------------------------AATTTKCPMCNEPYTS---VQRIYF-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000002312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MFRC ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QYPV---SPYM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RNEES RFETF------------------------------------------------------- --------------------------DH---RWPASNVRASPRQIAIAGFFF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ -----------------------------------------------------WDPDDEP WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--TN------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IIN------------------------------- ------------------------------------------------------RR--LT SGGNLYT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SVADL----------------VDDITA--NENEPN----SDDDDE-- -TNTSQPSQTTTVKT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TE R----------------------------------------------------------- --------------------------KC-------------------------------- ------------------------------KICLD------------------------- ------------------------KVADIVFVP-----------------CGHLC----- -TCTEC------------------------------------------------------ ---------------------------AKALRKCPICRSKFER---GIKTYM-------- ---------S-------------------------------------------------- ----------- >C_intestinalis_ENSCINP00000000047 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MQTARVVEPT---------------------------------- ---------------------------------KPASQYQRVELATIASPYHEKLVRSLD LRKESDRFKTYEN-------WPAQN-RTVYASDLARSGFF---YL----GNLDRVQCFSC GGVLRNWNYGDNITAEHRRHFPHCRMVQGTETRN-VASAVPPPQPIPPRGPGIQEPPDPN ETEMRDLM-------------------------NMFRC---------------------- --------------------------------------QYPV---SPYM----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RNEES RFETF------------------------------------------------------- --------------------------DH---RWPASNVRASPRQIAKAGFFF-LGDRD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RVKCWYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGGLQN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------- >B_taurus_ENSBTAP00000046955 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RC---EFLIRM-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEFVSEIQARYPH-LLEQ--LLSTANTS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GDENADPP--IVHFGPGESSSDD--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AV--------M-M NTPVV---K--------------------------------------------------- ------------------------------------------------------------ ------------AALEMGFSRSLVKRTVQ------------------------------- ------------------------------------------------------SK--IL TTGENYK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TVNDI----------------VSALLN--AEDEKREEEKEEEKER-- -QTEETAS--DDLSLLRRNR---MALFQQLTC-VLPI----------------------- -----------------------LDNLLKANVINKQEHDIIKQKTQIPLQARELIDTV-- ------------------------------------------------------------ ------------------------------------------------------------ -LVKGNSAASIFKNCLKEIDPTLYKNLFVEKNMKYIPT-DV--SG--LSL--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCMD------------------------- ------------------------KEVSIVFIP-----------------CGHLV----- -VCQEC------------------------------------------------------ ---------------------------APSLRKCPICRGIIKG---TVRTFL-------- ---------S-------------------------------------------------- ----------- >O_cuniculus_ENSOCUP00000002871 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QQD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KMRCFFC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------YGGLQS------------------- ------------------------------------------------------------ ------------------------------------------------------ERGDD- WTEHA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KW---------------------- -----------FP--RC---QFLLRS-KG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RDFVHSIQESGSQ-LLGPWDLWEEPEDT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AP--AS PSGPVHQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------APELLT--PRTEPW----LESARE-- -PGGTRAR--LRVQRVLGPP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GAGAVAM--EEQ----- ------------------------------------------------------------ -------------------LRRLQ------------------------------------ ----------------------------------------------------------EE R----------------------------------------------------------- --------------------------TC-------------------------------- ------------------------------KVCLD------------------------- ------------------------QAVSVVFVP-----------------CGHL------ -VCTQC------------------------------------------------------ ---------------------------APNLHLCPICRAPVRS---CVRTFL-------- ---------S-------------------------------------------------- ----------- >A_gambiae_AGAP012677-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MPQTPERMADAGFFY-TGKSD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VVACFYC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGNLRD------------------- ------------------------------------------------------------ -----------------------------------------------------WLAEDDP WVEHV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RN---------------------- -----------FS--EC---PYVKLV-KT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PEFIAECRGEKVT-NSALTAGPEHSGHG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NVSK--DKE----- ------------------------------------------------------------ -------------------QDEVS------------------------------------ ----------------------------------------------------------DE K----------------------------------------------------------- --------------------------CC-------------------------------- ------------------------------KICFT------------------------- ------------------------RPFDTVFMP-----------------CGHVV----- -ACGRC------------------------------------------------------ ---------------------------AATTTKCPMCNEPYTS---VQRIYF-------- ---------S-------------------------------------------------- ----------- >A_gambiae_AGAP002651-PA ---MASSSSSDDQWLKEDGYLNVDAESRSITYHPYLNVILVVGSNGEVKLLDVNSGVILQ SYRISGTDLNTVRCRYLPQQDKMLIWNGRNICMRGDYNGVLLLDTILQAPVTSTDDRVRL ELLLSEALLFLQCLQNLEEHGLENMSDVTNELTQKIGEAQAHSKRGIKAQKWETVCLELP HSSLRMVASGVVMQLRRLDQHIPAM-AIASAINERLTDLLRGARVTESA----KSVQRFQ MYSEAARRQTFEA-------WPHMDYKWVLPDQMAQAGFY---HQPGENGNKDRAMCFTC TVCLVCWEKTDEPWSEHERHSPECPFVKGEFTQNVPLSVTYATSPAIATGGFSLISSGDR GVVFCTGN-------------------------PSGDVTVWNIERQLTKVHEFQVKLHPD ILTTTTISPTATVNSIELSALAAYFVRTPPGMILMPRRASLS--LKPKMLGTKIVAGVRV NSTEPFDEDMDAYKHEPETTLLLIVYNIEDPLLEDILHGVPMAVANGMPMAMANLPPGAT VTLNAGVGANAKKTSLFTIMESTEDDAVKLLSERTNLLMDELKSAKHKLITQKSNKAKKK QYADVSENDSSDVSALAPADTMPHTTLPSTSMNIKEAIYCIPLQYIELPPILIDSYDHYY ISDTVPSSDNKYLLVVVKYDASTAAKDAPTAKESGVPTANAADEADEQQKQTTDGAESAG PRWYAILFLYFLNEDGLVRLDDPLTTCLKQEQVPLEITMLPKCDGTGRHFGGPETEQGIF VMTCADGKLRIVSLKTLGIISEASVKDDRFVSVTYCKSLERLCGCTAKGCLHFYSFYDLD ADSSDERDEEIVVPSPAAIDATDVPCGGTARADGVQSMDDIDNVTAASTAGAEEKQTNAG STGTAQRTQTQQQQQQQQQQSQHHPDGDIGNVNNLKMLHTFTLFSELLTPYSAEVPACWN ELEQAQKQRRNPQHLRPGDDTHLTKTWRLHNDASTWDEHLIELNLPKCTSLGHIDFKFSL YQPCANSPAIQVTLLKQKSMGLCTRRKTQSINRVDESINFNIGAGEGKHFVENPVLSEEY LQARNAEIVVGPIELASCMDLSEQGGCVTLTSPKLLKSKGRNYLLHIKTMTDLSKDGQGK TRGKQTNGTGVGKSWLRRTTLGVFFPPIRSCLVFIKMLKARERKCFNEMELFLHSLFLRP GCDWLNEISITVRATRQLYKVEQERAQRLAMLDSNMLLENLLGLLHQSTAETAELVDDGS GQENGTISPGENTIIMQQNLAIDILIWIVTIRMMRYRYPKNPFAKRAAPTELRKVASTDL NIQQTECVQIIEKHLEQTIRHCIVLANRSIAHKCVKFISLALEGAQNMVDKNVCNAFEQT LNDAIIKCLPDVVNCNNAGALRWFALLISGTTLAENHLSIADHCLTLLKSVAEELQKRNN PYTALLRTRFGLHGSPFDSEVFDAQLMDGRVAFGGGVAYPFGAGGTLGSSVLSGPSSIDL RLMCFADGADLKCLFDQLRNRSIGSHFVGLLEVEPLHYSCCATSDATRLENENLADGMMN NVKNVLVDKIFFSALQKHKLKSAGNSSADTIGFPTYLQQTSTDSHAKPHAIN-IGSSDSE MAKELETFDDMYVDDLSCDMFNPTLIITDTAAAESAAAHGTASNSVADGPRSSKGVSFTA NDANLDLQQGPLTSLLDNKIQEYFEDKSAEAEYAADQSGGLPWHKLLASPPKQTIVVERM HSSAIRYVTLDFGAPIMLTDVIIPAHSDLASLSIDVWCFEEEADSVRLVVSQDIHSRTLV LSDLQPPPICRYLKITITGRYGMTATRCRIPMGSFYGHIVILDREAYADPVMKFLQKRKT NVQTQIKILKALYEDVHCRYCLASSKLMDLLVPYFNSDASNIAHMQAFLNRMKDTSFGGA LGSDGVPAECAKVTAAYEECIGFQHQLNVIRRVIDRIRPSVDLKHPTLAQLMLPTQPTPL KPGDDLSSIYTDKLRIMSECLIEVVLQLVTTYGSMPVQHISQDMCNLLFDTMVIAGDAHT QLATCSMLVRMCCLESCRTTVIDAILRSLATLLAPLATSGASGMSIWCSTDLNLIGWILL FLSVCLDDGTEGRKDQNNMRWDFMSGETDMVKARMNINNSGLRTLTRSFKKRLIQTKQYS SLTGGEIGNSIMVPSSLSKNETAGQDGSSAMSSSSGGGMHATSSTASNMTQLLSSGSKGV GKFVNIGGERTIRDTSSDTVMGHGMSASKGAGDTADGETPFDAGLKSMKIGKIIVVIRGL IGLLLSMDFTCNMDLFLITCKIVARLVLACRPALQLSKIITTNQLLQLIRIAVWENQQQP WAVHAITCLLQDVLEADKSFKDDENDTSDSPNDDGAAVPYKQQHPMQSTAHHVSCDLSYA DVAKSQLPSVVECDDPEMEEILIIDEIFSAREKRFHRRDIGAFASFSSKYSITNKPVSVA MDARLEMGLDTNVEIVLRRLTTRSAFNLITSLPHVAMMPELLGIGASAGQPSDSLPPWPD TITDVWSGPEYLQGMETNVMLTEVFDNILSDLHQLDSWLNLEKILQLWLTLNGETLENIP GSCSTGLNPYSFP--RI---PFGDRAVKGLLKALASHPNIKLRAWCLGFHCLILACKPHF EADCLDNMASSSDNHFRRMGTMIVQDENFEKMLLRFFSGADQSLISMDGGSSRYAGPTVC KLVVELFIWLEIRCNVGEELKQTLLRVTLHLVQFGGAIANQQGPIDAQSQMIKELLNVPF NKSDLGIAMSIIECVSHLVYNNVVNVEKLYCQKTVESNNSGGMLGGGMRFSSLFATVFNA ESNRACKTATDSSLLVDLLKLASILVNTKNPHVSTGADGGSTAEDTASATSGSGETRPKV PCFADTVLQHSPT-MNRLLSTLSHCSHSSLTMLVASTVSYGNGADSGSVKNLRNTYPELC TVADAVFQLLLYLSRTASQNELIVKPLFEYINNASNARHAMPKLHLSEPFLWFILKVLGT PSSVAIFTELGGIQVLCESLVRSNRALINTQPSLVSMIMQRLSKSSVGLHGTGGVGGSGM AGGNGGGSSSKKSTPIVTTPRNEEGLINFAPYSTITSDNQSVQAADVLIQTPIASHRRAR NPAWSYLFYPNESNVDLTITLPTAVLLKEVQLQPHLATLATCPSAVAIEVTRDSILGPIP ITQPISTVGMTCIRLRFAQPEIATSVIIRLYRPRDSMNIGLTQISILGTTTFGELTQPGP SGFGGSPMQNWPSCPMVAFNGASGSGARTSLGWLRVLTQCFGVTIYYADQQLANRVIDAA NEVTGFMEACCALLNIAPNSPNDTLQNLETVLLKLGLHSREMGLRLINTLLRQSIPQTFQ LSNDSISDLLYQLCTMQNEHTRDRLQAMLEWVLTLYERYRQSMAAGGTSTINQHRLALHA TNPYSGFVRCLAAILWQAFATDLIPELLDMVSRELFDVLFSWVQELEQHEGGAGAGPLKK AIDALLCSVCCIRPEFFTMLLRRMGVLVPNLSTDLTASISDDRKDGERRTDDSKQE--ES DTTEWYSHLVIEDIASLDLSSSQLATIAMASQSPLAIQQLIDSGLPKLLNSVILEFCRRA TNYVERMRRGTVRAAASCTSQSGAAASSAGAGSTEGACLTDADKWSGSESTESAKLHPMV NIHKVTEILAFFTEMCSEGHMRDWLGSHEGAIFWEPLLLLLCNSQLANVTRDITTQSCLE LEECFIKFLSRATTCHPKNQEVLTINLISVIRKSDPTEEAMHGGPTDGAAPPTTSAPPLL RSCISGFTRRLVLQILLESEKIMVAVRSDLPLLQSKEVSGTGAGGLYNSIANHPSKRPNA HLMLFQLSTNAKCQDILDQCAAAVYQPILPSAVPAATSVATASQPAGSSSSAQGCRDSEL WELGIGLEFLSVAAGVTAKDKRLKEAKNQATTMRRKDLLSMFKMKMDDAKLSVPDGLFLT HSAVPEVIITSDTTISQLLTMLKSAGISLSIPCINLNLVTTDAPSSGESSSMSSSSGP-- -GSSAYMRATEFLPLPSPLQIFSSRGGLSLLAHYLPTVYPEMPKTSAYYMDKDRSPSGAA GVGSAGAGNEWVKLEQMDEIYEDLDDIVAESSPKAQAITAIPQHSLAAFALFLKLPAYSE VLLNDTVRAQCLLRLILGVTSDGEGNEIYSLPLSSTLPTLPFEVFRQLLESSPLTTDDGV LLRRMVIEVGAIHLVLNCLSIFTHHNGSGCSVRTAGAASGQAGTSAATRISTGTGTNKSS STMTGNATANNTEDQLNADDKGHMYWAKGTGFGTGSTQQSWNVEQALMRQKSEEEHVTVL LQVLSSYINPGCNSYVISSGTEELHNFKDSFESVGELPPIFLDLIQQSCLIPALSSYLRN DSVLDITRHIPLYRAILQLLRAISVSNQLAMLLVNKSASEGKLSIAGLLSNMKACVDTYA SRLKVNKKSNLKGQTQKIIVSLDDGDDEGLALMMHDIQLTSLLVQNATNIDITNAAEEEE KQLIPRPITKSVEDKYLEIMKALQFDTYEMIAESENGYRFTISHHFETNVRMAGDRGHPG RVKRLAQETVTLSTSLPLSYSSSVFVRCDTDRLDIMKVLITGPAETPYANGCFEFDVYFP PDYPNSPMMINLETTGRNTVRFNPNLYNDGKVCLS------------------------V LNTWHGRPEEKWNAHTSSFLQVLVSIQSLILVPEPYFNEPGFERSRGTPTGTHSSREYNS NIYQACVRYAML------------------------------------------------ ---------------------------EQLRHPCPCFQDVIHAHFWLKRNEICNQIEEWI AELSHPLQHERTGRTISFNAMVLRRQYRQLREELAKLTPPEGLEEADFPFNAGSNVTPTT PSTAATSTTTA >A_aegypti_AAEL000590-PA ------------------------------------------MWCLINLPNGTTSGVQCD PKKNS---------QECLEKVCNDLGIICETDYFGLI-------------PVRDGDGAEV DECSA--KQWINLRNPLSLHANDRHPILLSLRVKFWVPAHLILQD--------------- -----------------------------------------------------SVKKLFY MQARQELLDGHISA------ASWENAAHISALLLQADGYI---Y--------DPNKVFAN LTGLERGSPLNTVDRRQLRR-PSKRKCSETDVKR-------------------------- ------------------------------------------------------------ --------------------------------------GSIASTVTVDD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AVSET EPKNI------------------------------------------------------- --------------------------YQTYIVRPK-FEDVEPEPMPENFIQM-IAKEH-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SKIKM------------------- ------------------------------------------------------------ -----------------------------------------------------TASSAQY WVLEE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ISSLNG-YG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EEVFEGITINEPS-VRCKIGVSPHGLTI-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AKDDEKYNVPFTAVKAAKSIKRSFR--------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LTYMNEEHEETHI ELKLPNHRTAACLYRA-------------------------------------------- ----------------------------------------------------------IT EKHVFYSCETVRPVVTTQFIRDLKGTIVS------------------------------- ------------------------------------------------------MF--NE DTELGKR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YVFDIQRTCREVYDNARRVLHARGMEISKVQKECPQAQASKLDQQ-- -LADE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AEE--SNK----- ------------------------------------------------------------ -------------------LERLV------------------------------------ ----------------------------------------------------------EE RL---------------------------------------------------------- ----------------------TEALTC-------------------------------- ------------------------------IICAD------------------------- ------------------------NMIDTMFLP-----------------CGHIT----- -ACRQC------------------------------------------------------ ---------------------------AEQCDRCPLCRANIEC---VNKAFLPPVMRTRS QTAAANASAQSIEAH--------------------------------------------- -----------