10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 SSMFRRRKKTHKPEISAPLNFQHRVHTSFDAASGHFVGLPPQWQSVI------DTLQRPRPLVDPSRI--TEIQLHKTIVR---------------GSFIGHGAYISHIIAEMSRLSVIS R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038069 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022839 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA --MAGRE--------------QYQV-----KDRDDTMGL-----TIVFDSGII------------------------------------------------------------------- G_aculeatus_ENSGACP00000018211 --MFQRRKRKRRPKISAPQDFRHRVHTSYDVATGRYVGLPPQWQSVI------DTLRRPRPLVDPSRT--TEVQPRKTIVR---------------GSFIGHGDYISQVISEMSHLSVTA G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA --MFSKKKK--KPQISFPSNFEHRVHTGFDKREGRYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTEILDLKTIVRPHGPQGGPPAAGVSGGPAVAAPDQQGKLILPKTS-NVAR 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 SNSLRRSSQ------------SSRKRAQSMGQLGELREDESY--------EY-KTPTGAAASKTGSSPYWRDSIQRAHSNSVGPKK----------------------KGALQRTKSSCE R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005164 ----------------------------------------------------M----------------------------------------------AAHKELSSGQHSGTPTA---- T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000043572 ----------------------------------------------------M----------------------------------------------AAHKELSFGQHTGTPTA---- P_troglodytes_ENSPTRP00000022091 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003153 -----------------------------------------------------------------------------------------------CGRQGGLLAPPAPAAAAAARAAAAA M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 -----------------------------------------------------------------------------------------------CGRQGGLLAPPAPAAAAAARAAAAA P_troglodytes_ENSPTRP00000005279 -----------------------------------------------------------------------------------------------CGRQGGLLAPPAPAAAAAARAAAAA O_cuniculus_ENSOCUP00000001738 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038069 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022839 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014351 ----------------------------------------------------M----------------------------------------------AAQKEVPCAQCTGTATA---- T_guttata_ENSTGUP00000006845 ----------------------------------------------------M----------------------------------------------AGHTEVPCSQGSGTATA---- C_elegans_ZK909.2c ----------------------------------------------------MEEEEWRRRLSAAIRREDEGSLEEDEEDEGFILHPLCRTGPLQMTVKASNSTTTLTPSSTTTTSPSMP M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ----------------------------------------------------M----------------------------------------------AAQKELQGNPSTGTANA---- A_aegypti_AAEL007931-PA --------------------------------------CHPYPG------QYPGSLQGHPQHGTGPPPLHSKPNFSSSPLGQGPST---------------VPPSHTNHVHHQGMHGPSV G_aculeatus_ENSGACP00000018211 SNSLRRYSP------------SARQRARSLGLLGDLADEESY--------QYERLGCRSNGMKTSLSTYWQDRIQQVCSD-----R----------------------GASLQRAKSTCE G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA SNSLRSSSPPRHFVFIFRSQKSSPTGSDGMQRPGGYPNAAPYPGPMQAGNSFPGMAQG-AGGGGPPPPLHSKPQGQNHPGQQQPQQQDPHGHLGDANNGNHLPPGHHHHHHHHQMMGV-- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036490 ------------------------------------MSEEAGPSGESQSQTQSQTQSQPASSSSSAPTSSSQGSSSGSGTLSSVDTVPVQELQSIPEDEEEVQPQVWGRIIPLKQGFSVL O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.12 ----------------------------MVRGTKRRRSSAEKPIVVVPVTRDDTMPVDEDLVVGESQCAASKPFAKLVGVRRGISSIDLADDHFVCGRGSDDAPTNFNFSQVAKDVGLYR C_elegans_T08D2.7 ----------------------------MVRETKRRRSSAEKPI-VVPVTRDDTMPVDEDLVVEESQCAALKPFAKLVGVRRGISSIDLADDHFVCGRGSHDAPTNFNFSTVAEDVGLYK R_norvegicus_ENSRNOP00000020214 ---------------------MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVAEYEVTPDEKRK O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------AEYEVTPDEKLG T_rubripes_ENSTRUP00000010568 VSAPPEATPTVTTVGHYREAQ-----------YQQKPNSCHTD--ARTGKTHSCEQPPDLLSSPCQPDGLQTNHMVTVINPGSRTPVINSDVPVFFQRHPPSSALYLPPPNST------- R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003153 AAAPQALTAPPAGSLADRRLSMELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLG M_mulatta_ENSMMUP00000006107 ----------------------------------------------------------------------DRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLG H_sapiens_ENSP00000358104 AAAPQALTAPPAGSVADRRLSMELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLG P_troglodytes_ENSPTRP00000005279 AAAPQALTAPPAGSVADRRLSMELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLG O_cuniculus_ENSOCUP00000001738 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038069 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017912 ---------------------MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLG E_caballus_ENSECAP00000008449 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000053464 ---------------------MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCIAFLDGVAEYEVTPDEKRK M_musculus_ENSMUSP00000084430 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022839 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c SSPSDSPSDDFSDDTNTSGVFPLTTALSFPVAPLSPRNTTSSITTGLVKKRRSSSSPEDICREKIPHILLKTSSGVVVPLASRGQRAPAITLQNPPPSAAIRTVPPPSFSTFSVRSLPFK M_musculus_ENSMUSP00000001115 ---------------------MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELTRCTAFLDGVSEYEVTPDEKRK B_taurus_ENSBTAP00000001970 --------------------------------------GGINKKSGRSKKWREMLRLPPVSQCSELRQSVEKDYSSLCDKQPIGRLLFRQFCDTKGDLKRRIEFLDAVAEYEVAADEDRR A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA TGQSGMATPQLDLGPSNPVPH----------HHHHHPNHMGGAPGAASSHQHQPQQQQHLPPHNQQQHAMPPGSNGPMNGPGQ-----------FPGHHQPTIHHKMPSPASITGSTAEP G_aculeatus_ENSGACP00000018211 VGSSSVATPPMPASPQTTGANGAGASTGGRVGQRQRPASCYNP--LQTGKNSR----PHLRPRPAHLPDLLSSARETPRRPHSS---YNLNVYLLPQLSPYAS----PPPIST------- G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA --QGGNTGPQASGSQLSPSGL----------HHHHQHAHHHGA------QQQQQQQQQQMQPTPLQ-----------MGGNNQ-----------MPNHHH---HH--------------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF P_troglodytes_ENSPTRP00000055512 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF M_mulatta_ENSMMUP00000024306 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF C_familiaris_ENSCAFP00000014093 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF B_taurus_ENSBTAP00000009985 ------------------------------------------------------RNSGGASGRSPSRPMER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF P_pygmaeus_ENSPPYP00000002975 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF R_norvegicus_ENSRNOP00000034134 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF M_musculus_ENSMUSP00000026217 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------WEMRERLGTGGF G_gallus_ENSGALP00000005196 ------------------------------------------------------MERGAERGPPPAPGGVA-----------LRG-------------QPAGG--CGPWEMRDRLGTGGF O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ----------------------------------------------------------------------------------------------------------GPWEMRDRLGTGGF A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 --------------------------------------------------------------------MEK-----------PPV-------------QHGAV--CGPWDMKDRLGTGGF T_rubripes_ENSTRUP00000022821 --------------------------------------------------------------------MEK-----------PPF-------------RQNQN--CGDWELKERLGMGGF D_rerio_ENSDARP00000013115 --------------------------------------------------------------------MEK-----------PPF-------------RQNQV--CGSWVMKERLGTGGF T_nigroviridis_ENSTNIP00000014802 --------------------------------------------------------------------MEK-----------PPF-------------RQNQN--CGDWELKERLGMGGF O_latipes_ENSORLP00000016017 --------------------------------------------------------------------MEK-----------PPF-------------RQNVN--CGDWEMKERLGMGGF G_aculeatus_ENSGACP00000005520 --------------------------------------------------------------------MEK-----------PPF-------------RQNQN--CGDWELKERLGMGGF G_aculeatus_ENSGACP00000008884 --------------------------------------------------------------------MER-----------TPL-------------RHNQM--CGSWEMKERLGTGGF T_rubripes_ENSTRUP00000036336 --------------------------------------------------------------------MER-----------FAL-------------KQSQL--CGSWEMKERLGMGGF G_gorilla_ENSGGOP00000008804 --------------------------------------------------------------------MER-----------PPG-------------LRPGA--GGPWEMRERLGTGGF O_latipes_ENSORLP00000011761 --------------------------------------------------------------------MER-----------SAL-------------KQGQL--FGSWETKERLGMGGF T_nigroviridis_ENSTNIP00000019642 --------------------------------------------------------------------MER-----------FAL-------------KQSQL--CGSWEMKERLGMGGF M_mulatta_ENSMMUP00000010949 --------------------------------------------------------------------MSW-----------SPS-------------LTTQT--CGAWEMKERLGTGGF H_sapiens_ENSP00000339151 --------------------------------------------------------------------MSW-----------SPS-------------LTTQT--CGAWEMKERLGTGGF M_musculus_ENSMUSP00000033939 --------------------------------------------------------------------MSW-----------SPS-------------LPTQT--CGAWEMKERLGTGGF C_familiaris_ENSCAFP00000008270 --------------------------------------------------------------------MSW-----------SPS-------------LPTQT--CGAWEMKERLGTGGF A_carolinensis_ENSACAP00000012680 ---------------------------------------------------------------------AP-----------PPL-------------QPLAS--CGAWEMRERLGTGGF R_norvegicus_ENSRNOP00000025851 --------------------------------------------------------------------MSW-----------SPS-------------LPTQT--CGAWEMKERLGTGGF G_gallus_ENSGALP00000005924 --------------------------------------------------------------------MSR-----------PPA-------------LQAQT--CGPWEMKERLGTGGF O_anatinus_ENSOANP00000001111 --------------------------------------------------------------------MSW-----------PPS-------------LQTQT--CGVWEMKERLGTGGF P_troglodytes_ENSPTRP00000034602 --------------------------------------------------------------------MSW-----------SPS-------------LTTQT--CGAWEMKERLGTGGF O_latipes_ENSORLP00000003067 --------------------------------------------------------------------MNR-----------VPL-------------QQPQT--CGPWELKERLGTGGF B_taurus_ENSBTAP00000049055 --------------------------------------------------------------------MSW-----------SPS-------------LPTQT--CGAWEMKERLGTGGF M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 --------------------------------------------------------------------MTHQDASPGRAGWAPPP-------------SHTQI--CGPWEMKERLGTGGF P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 --------------------------------------------------------------------MNR-----------VTL--------------QQQS--CGSWELKERLGTGGF T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 --------------------------------------------------------------------MNR-----------VPL-----------QQQQQQC--CGLWELRERLGNGGF E_caballus_ENSECAP00000003662 --------------------------------------------------------------------MSW-----------SPS-------------LPTQT--CGAWEMKERLGTGGF T_rubripes_ENSTRUP00000041917 --------------------------------------------------------------------MNR-----------VPL-------------QQQQS--CGLWELKERLGTGGF G_gorilla_ENSGGOP00000006628 --------------------------------------------------------------------MSW-----------SPS-------------LTTQT--CGAWEMKERLGTGGF O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 --------------------------------------------------------------------MSR-----------PPA-------------LQALT--CGPWEMRERLGTGGF A_aegypti_AAEL003245-PA --------------------------------------------------------------------MMA------------QS-------------EDPPF--IGDWHREKRLGSGGF A_gambiae_AGAP009166-PA --------------------------------------------------------------------MIK------------PF-------------EDPPQ--IGEWCREKRLGNGGF A_aegypti_AAEL010548-PA ---------------------------------------------------------------------MA------------QS-------------EDPPF--IGDWHREKRLGSGGF D_melanogaster_FBpp0082690 --------------------------------------------------------------------MITVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGGF A_aegypti_AAEL005359-PA ----------------------------------------------------------------------------------------------MNSFLRGST--NYVWCTTSVLGKGAT A_gambiae_AGAP009565-PA ----------------------------------------------------------------------------------------------MNSFLRGSM--NYVWCTTSVLGKGST A_carolinensis_ENSACAP00000012863 --------------------------------------------------------------------------------------------------MQSTL--NYLWKTDDVLGQGAT C_intestinalis_ENSCINP00000011687 -------------------------------------------------------------------------MTRFGHDVNNNFGTMNPHPAHNSSPIRSTL--NYVWSTTEILGQGAT D_rerio_ENSDARP00000014302 --------------------------------------------------------------------------------------------------MTSTA--NYLWSQEDILGQGAT D_rerio_ENSDARP00000074566 --------------------------------------------------------------------------------------------------MTSTA--NYLWSQEDILGQGAT D_melanogaster_FBpp0080920 -----------------------------------------------------------------------------------------------MSFLRGSV--SYVWCTTSVLGKGAT D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 --------------------------------------------------------------------------------------------------MQSTT--NYLWLISDLLGQGAT H_sapiens_ENSP00000356087 --------------------------------------------------------------------------------------------------MQSTA--NYLWHTDDLLGQGAT P_pygmaeus_ENSPPYP00000000308 --------------------------------------------------------------------------------------------------MQSTA--NYLWHTDDLLGQGAT G_aculeatus_ENSGACP00000000783 --------------------------------------------------------------------------------------------------MQSTT--NYLWLISDLLGQGAT T_rubripes_ENSTRUP00000005087 --------------------------------------------------------------------------------------------------MASTP--NYLWSLQDVLGQGAT M_mulatta_ENSMMUP00000038190 --------------------------------------------------------------------------------------------------MQSTA--NYLWHTDDLLGQGAT O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT P_pygmaeus_ENSPPYP00000005386 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT M_mulatta_ENSMMUP00000010063 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT P_troglodytes_ENSPTRP00000008798 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT E_caballus_ENSECAP00000018587 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT B_taurus_ENSBTAP00000046540 --------------------------------------------------------------------------------------------------MQSTV--NYLWHTDDLLGQGAT H_sapiens_ENSP00000329967 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT C_familiaris_ENSCAFP00000000505 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT R_norvegicus_ENSRNOP00000009260 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT M_musculus_ENSMUSP00000020316 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT A_carolinensis_ENSACAP00000003243 --------------------------------------------------------------------------------------------------MQSTS--NYLWLLSDILGQGAT E_caballus_ENSECAP00000000587 --------------------------------------------------------------------------------------------------MQSTV--NYLWHTDDLLGQGAT T_guttata_ENSTGUP00000006693 --------------------------------------------------------------------------------------------------MQSTS--NYLWLLSDILGQGAT X_tropicalis_ENSXETP00000015947 --------------------------------------------------------------------------------------------------MQSTA--NHLWLLSDILGQGAT M_domestica_ENSMODP00000002458 --------------------------------------------------------------------------------------------------MQSTA--NYLWHTDDLLGQGAT B_taurus_ENSBTAP00000023134 --------------------------------------------------------------------------------------------------MQSTS--NHLWLLSDILGQGAT G_gallus_ENSGALP00000021757 --------------------------------------------------------------------------------------------------MQSTP--NYLWSTDDLLGQGAT G_gallus_ENSGALP00000015982 --------------------------------------------------------------------------------------------------MQSTS--NYLWLLSDILGQGAT R_norvegicus_ENSRNOP00000030127 --------------------------------------------------------------------------------------------------MQSTT--NYLWHTDDLLGQGAT X_tropicalis_ENSXETP00000017637 -------------------------------------------------------------------------------------------------VQQSSRTSIEDYDLKSLLGTGGF M_musculus_ENSMUSP00000054126 --------------------------------------------------------------------------------------------------MQSTT--NYLWHTDDLLGQGAT D_rerio_ENSDARP00000036490 NCTENQYSFGRDKRCDYSFSNSILKKSPYFNTYSKKHFRIFRDENLVYLEDLSGNGTWVDDEKLGNGKQSLLSNNSVIALAEQKHQVFMFIDKMADDQANLPLEFSKKYHIARKIGTGVC O_anatinus_ENSOANP00000008566 --------------------------------------------------------------------------------------------------MQSTA--NYLWHTDDILGQGAT C_elegans_Y60A3A.12 FISKIQFSIDRDTETRRIYLHDHSRNGTLVNQ-----------------EMIGKGLSRELMNGDLISIGIPALIIFVYESADADH------------HPEELT--KKYHVTSHSLGKGGF C_elegans_T08D2.7 FISKIQFSIDRDTETRRIYLHDHSRNGTLVNH-----------------EMIGKGLSRELMNGDLISIAIPALIIFVYERADDNH------------HPEELT--NKYHVTSHLLGKGGF R_norvegicus_ENSRNOP00000020214 ACGRRLMQNFLSHT-GPDLIPEVPRQLVSNCA-----------------QRLEQGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF O_latipes_ENSORLP00000008832 ------------------------------------------------------------------AAIFTHNMFLFAVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGSF B_taurus_ENSBTAP00000010492 EKGKEIMTKYLTPK-SPVFITQVGRDLVSQTE-----------------EKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF T_rubripes_ENSTRUP00000010568 SSPLITVRGLLPHSSHPPSSSHIR---LRSTS-----------------IPGI----TKPHPSQLQDPPTTCPSATHLLLPDGRINVTHDQFKAALQSVVDAGDPRTMLENFVKIGEGST R_norvegicus_ENSRNOP00000024227 ----------------------------------------------------------------------------------------------MLLLKKQTEDISSVYEIREKLGSGAF M_musculus_ENSMUSP00000110117 ----------------------------------------------------------------------------------------------MLLLKKQTEDISSVYEIREKLGSGAF M_mulatta_ENSMMUP00000008885 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF M_musculus_ENSMUSP00000005164 -----------LQKLEGFASRLFHRHSRGTAQ-----------------------EHRAALEDDGLRASEHTASWDKSMKEFLAKAKEDFLRKWENPPPSNAG--LEDFERKKTLGTGSF T_nigroviridis_ENSTNIP00000012244 ----------------------------------------------------------------------------------------------------SGT--EKIYHFGSKLGQGGF P_pygmaeus_ENSPPYP00000014729 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF T_nigroviridis_ENSTNIP00000013350 ---------------------------------------------------------------MGNTPTTKKGNEMESVKEFLAKAKEDFLKKWENPAQQTAA--LDHFDRLKTLGTGSF H_sapiens_ENSP00000295709 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF R_norvegicus_ENSRNOP00000043572 -----------LQKLEGFASRLFHRHSKGTAQ-----------------------DQKAALEEEGLQASEHTASWDKPMKEFLAKAKEDFLRKWENPPPSNAG--LEDFERKKTLGTGSF P_troglodytes_ENSPTRP00000022091 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF P_pygmaeus_ENSPPYP00000003153 EKGKEIMTKYLTPK-SPVFIAQVGQDLVSQTE-----------------EKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMYFDRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF M_mulatta_ENSMMUP00000006107 EKGKEIMTKYLTPK-SPVFIAQVGRDLVSQTE-----------------EKLLQKPCKELFSACAQK-HLLLRA-----YSESWHRETSVQCGTLLSSRQPVT--KNTFRQYRVLGKGGF H_sapiens_ENSP00000358104 EKGKEIMTKYLTPK-SPVFIAQVGQDLVSQTE-----------------EKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF P_troglodytes_ENSPTRP00000005279 EKGKEIMTKYLTPK-SPVFIAQVGQDLVSQTE-----------------EKLLQKPCKELFSACAQ---------------------------------QPVT--KNTFRQYRVLGKGGF O_cuniculus_ENSOCUP00000001738 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF B_taurus_ENSBTAP00000038069 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF C_familiaris_ENSCAFP00000017912 EKGKEIMTKYLTPK-SPVFVAQVGQDLVSQTE-----------------KKLLQRPSKELFSACAQSVHDYLKGEPFHEYLDSMYFDRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF E_caballus_ENSECAP00000008449 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF B_taurus_ENSBTAP00000053464 ACGLRLMQNFLSHT-GPDLIPEVPRQLVTNCA-----------------QRLEEGPCKDLFQELTRLTHEYLSMAPFADYLDSIYFNRFLQWKWL--ERQPVT--KNTFR-YRVLGKGGF M_musculus_ENSMUSP00000084430 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF R_norvegicus_ENSRNOP00000022839 ---------------------------------------------------------------------------------------------------------MEKYHVLEMIGEGSF G_gallus_ENSGALP00000014351 -----------LQRLEGFANRLFHRHSKGGAH-----------------------DLRVPLENESHHVSELAVLWDKSMKEFLAKAKEDFLRKWESPPQNTAG--LDDFERQKTLGTGSF T_guttata_ENSTGUP00000006845 -----------LQRLEGFANRLFHRHSKNGAH-----------------------EQRAALEGESQQCSEFTVQWDKSMKEFLAKAKEDFLRKWESPPQNTAG--LDDFERQKTLGTGSF C_elegans_ZK909.2c TPNCGSKDDTDAENMEGLDDDYLRQPTTSTSA-----------------PVSPIDHRQVRRGGRGVVVESQVPNFTAEIFWLKTQLSDHWSMKWL--FQNTAC--LDDFDRIKTLGTGSF M_musculus_ENSMUSP00000001115 ACGRRLMQNFLSHT-GPDLIPEVPRQLVSNCA-----------------QRLEQGPCKDLFQELTRLTHEYLSTAPFADYLDSIYFNRFLQWKWL--ERQPVT--KNTFRQYRVLGKGGF B_taurus_ENSBTAP00000001970 HCGLLVLGTCFSLKGSPAPLPEIPEHVVLKCR-----------------QRLWEDPSKDIFEECTRIVHDHLSEEAFEEYQESAYFSRFLQWKWL--ERQPVT--KSTFRHYRVLGKGGF A_carolinensis_ENSACAP00000005713 -----------LQRLEGFANRLFHRHSKGSSS-----------------------ELKAAQENESPHFSELAALWERSMKEFLAKAKEDFLRKWESPPQNTAG--LEDFERLKTLGTGSF A_aegypti_AAEL007931-PA NVNSMNNNNPSTKANSRASSSSGGNISVAHST-----------------TSSVQTGGASQQGGSGST--------------KAEQRLTHEQFRAALQMVVSAGDPRENLENFTKIGEGST G_aculeatus_ENSGACP00000018211 SSPVIA--GPPQRLLRPSSTFNIG---LPAKT-----------------PPPLIETRSSPHPSSLSPYPEQ-------LAPDASVKVTHKQFKEALQMVVDPGDPRNTLENFVKIGEGST G_aculeatus_ENSGACP00000000485 -------------------------------------------------------------------------------------------------MTASTA--NYLWSLQDVLGQGAT M_domestica_ENSMODP00000006295 ----------------------------------------------------------------------------------------MPREVDGASWKKHADDIRDIYEFRDVLGTGAF A_gambiae_AGAP010874-PA NHNAMVHNH--QKMPSPSSSSSTG---APTST-----------------ASTTQSGQSQQQ---PPV--------------KTEQRLTHEQFRAALQMVVSAGDPRENLENYTKIGEGST 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES P_troglodytes_ENSPTRP00000055512 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES M_mulatta_ENSMMUP00000024306 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES C_familiaris_ENSCAFP00000014093 GNVCLYQHR--ELDVKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES B_taurus_ENSBTAP00000009985 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES P_pygmaeus_ENSPPYP00000002975 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES R_norvegicus_ENSRNOP00000034134 GNVSLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES M_musculus_ENSMUSP00000026217 GNVSLYQHR--ELDLKIAIKSC-----RL-ELSSKNRERWCHEIQIM-K---KLDHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES E_caballus_ENSECAP00000005937 -----------ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES M_domestica_ENSMODP00000013213 GNVCLYQHR--ELGNKIAIKSC-----RL-ELSAKNKDRWCHEIQIM-K---KLNHPSVVKAC----DVP-----EEMNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES G_gallus_ENSGALP00000005196 GNVCLYQHQ--DTGARVAIKSC-----RL-ELSVKNKDRWCHEIDIM-K---KLNHPNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES O_anatinus_ENSOANP00000003934 --------Q--DLGDKIAIKAC-----RQ-ELSAKNKDRWCHEIQIM-K---KLQSDSLVKACIRTSNIS-----EEQFSI--VSFKHPQLSREYCSGGLIERLILLNKTE-NCCGLKES T_guttata_ENSTGUP00000004836 GNVCLYQHQ--DSGDRVAIKSC-----RL-ELSVKNKDRWCHEIDIM-K---KLNHPNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES A_carolinensis_ENSACAP00000011973 ---------------KLAIKSC-----RL-ELSVKNKDRWCHEIQIM-K---KLNHPNIVKAC----DVP-----EEMNFL--VN-DVPLLAMEYCSKGDLRK--LLNLPE-NCCGLKES X_tropicalis_ENSXETP00000038296 GNVCLYQNR--ETGELKAIKSC-----RL-ELSMKNKERWCQEIQIM-K---RLNHPNVVKAC----EVP-----PEMDFL--VN-DVPHLAMEYCAGGDLRK--LLNKPE-NCCGLKES T_rubripes_ENSTRUP00000022821 AHVYLYQHR--ETNEKLAVKMC-----RL-ELTPRNKDRWSREIQIM-K---KLNHINVVTAR----DVP-----EEVTHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPE-NCCGLKES D_rerio_ENSDARP00000013115 GHVYLYQNQ--ETSEKIAVKLC-----RL-ELNSKNKDRWSREIQIM-K---KLKHLNVVTAK----DVP-----EEMMHI-ALN-DLPLLAMEYCSKGDLRK--LLSKPE-NCCGLKES T_nigroviridis_ENSTNIP00000014802 GHVYLYQHR--ETNEKLAVKMC-----RL-DLTPKNKDRWSREIQIM-K---KLNHINVVTAR----DVP-----EEMKHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPE-NCCGLKES O_latipes_ENSORLP00000016017 AHVYLYQHC--ATNEKLAVKMC-----RL-ELTPRNRDRWSREIQIM-K---KLNHINVVTAQ----DVP-----EEMKRI-ALN-DLPLLAMEYCSRGDLRK--VLSKPE-NCCGLKES G_aculeatus_ENSGACP00000005520 GHVYLYQHH--KTNEKLAVKMC-----RL-ELTPRNKDRWSREIQIM-K---KLNHINVVSAQ----DVP-----EEMRHI-ALN-DLPLLAMEYCSRGDLRK--ILSKPE-NCCGLKES G_aculeatus_ENSGACP00000008884 GHVYLYQHL--ESGEKIAVKLC-----RL-ELNSKNKDRWGREIQIM-K---KLNHGNVVQAR----EIP-----EELHSI-ALN-DLPLLAMEYCSRGDLRK--VLNKPE-NCCGLKES T_rubripes_ENSTRUP00000036336 GHVYLYQHLDQESGEKMAVKLC-----RL-ELNSKNKERWSREIQIM-K---KLKHGNVVQAR----EVP-----EELTSI-SLN-DLPLLAMEYCSRGDLRK--LLNKPE-NCCGLKES G_gorilla_ENSGGOP00000008804 GNVCLYQHR--ELDLKIAIKSC-----RL-ELSTKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES O_latipes_ENSORLP00000011761 GHVYLYQHV--ETGVKIAVKHC-----RL-DLSAKNKERWSREIQIM-S---KLNHLNVVQAR----EVP-----EELHAI-ALN-DLPLLAMEYCSRGDLRK--VLHKPE-NCCGLKES T_nigroviridis_ENSTNIP00000019642 GHVYLYQHL--ESGEKMAVKLC-----RL-ELNSKNRERWSREIQIM-K---KLKHTNVVQAR----EVP-----EELTSI-SIN-DLPLLAMEYCSRGDLRK--ILNKPE-NCCGLKES M_mulatta_ENSMMUP00000010949 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLTHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG H_sapiens_ENSP00000339151 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLTHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG M_musculus_ENSMUSP00000033939 GNVIRWHNQ--ATGEQIAIKQC-----RQ-ELSPKNRDRWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFE-NCCGLREG C_familiaris_ENSCAFP00000008270 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG A_carolinensis_ENSACAP00000012680 GNVIRWQHR--ETGEQIAIKQC-----RQ-ELSLRNRERWCLEIQIM-K---RLNHPNVVAAR----DVP-----EGMQSL-ALN-DLPLLAMEYCQGGDLRR--HLNQLE-NCCGVRER R_norvegicus_ENSRNOP00000025851 GNVIRWHNQ--VTGEQIAIKQC-----RQ-ELSPKNRDRWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFE-NCCGLREG G_gallus_ENSGALP00000005924 GNVIRWHNK--ETGEQVAIKQC-----RQ-ELSPRNRDRWALEIQIM-K---RLNHPNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLE-NCCGLREE O_anatinus_ENSOANP00000001111 GNVIRWHNK--ETGEQIAIKQC-----RQ-ELSTRNRERWCLEIQIM-R---RLNHPNVVAAR----EVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--FLNQFE-NCCGLREG P_troglodytes_ENSPTRP00000034602 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLTHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG O_latipes_ENSORLP00000003067 GNVTRWQNK--DTEEQIAIKQC-----RQ-ELSERNKERWKLEIQIM-K---RLNHVNVVAAR----DVP-----AGMQKLVTAN-DLPLLAMEYCQGGDLRK--YLNVLD-NCCGMREG B_taurus_ENSBTAP00000049055 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQSL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG M_domestica_ENSMODP00000012792 --------Q--ETGEQIAIKQC-----RQ-ELSLRNRERWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREE X_tropicalis_ENSXETP00000036619 GYVLRWIHQ--DTGEQVAIKQC-----RQ-ELSPKNRERWCLEIQIM-K---KLNHPNVVSAR----EVP-----DGLQKL-APN-DLPLLAMEYCEGGDLRK--YLNQFE-NCCGLKEG P_pygmaeus_ENSPPYP00000020804 ------------------------------------------SVFLL-P---RLTHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG O_cuniculus_ENSOCUP00000011297 -----------ELDLKIAIKSC-----RL-ELSSKNRERWCHEIQIM-K---KLNHANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPE-NCCGLKES G_aculeatus_ENSGACP00000005440 GNVTRWQNK--DTEEQISIKQC-----RQ-ELSERNKERWVLEIQIM-K---RLDHINVVAAR----EVP-----EGMQEMITTN-DLPLLAMEYCQGGDLRK--HLNLLE-NCCGMREG T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 GNVTRWQNK--ETEEQIAIKQC-----RQ-ELSERNKERWCLEIEII-K---RLDHVNVVAAR----EVP-----EGMQKLMAIN-DLPLLAMEYCQGGDLRK--YLNLLE-NCCGMREG E_caballus_ENSECAP00000003662 GNVIRWHNQD-QNGSSVASVQC-----RQADISIRSFQPWTFDSRAL-V---LLNHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG T_rubripes_ENSTRUP00000041917 GNVTRWQNK--ETEEQIAIKQC-----RQ-ELSERNKERWCLEIQII-K---RLDHVNVVAAR----EVP-----EGMQKLMVTN-DLPLLAMEYCQGGDLRK--YLNLLE-NCCGMREG G_gorilla_ENSGGOP00000006628 GNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLTHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFE-NCCGLREG O_cuniculus_ENSOCUP00000006175 -----------ETGEQIAIKQC-----RQ-ELSPRNRERWCLEIQIM-R---RLNHPNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--XXXXXX-XXXXXXXX T_guttata_ENSTGUP00000005662 GNVIRWHNK--ETGEQVAIKQC-----RQ-ELSPRNRDRWALEIQIM-K---RLNHPNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLE-NCCGLREE A_aegypti_AAEL003245-PA GFVTLWKNH--KTNEMVAIKKCHILLDKS-EMTDKNCERWCNEVSLMMN---KVRNENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVS-SCSGLKEL A_gambiae_AGAP009166-PA GVVTLWRNK--QTQQAVAIKKFHILQDRS-EITDKHCERWRNEVKLMTE---TVQNDHIVRTV----DVQPRAFIEELLRS-SAN-GLPVLCMEYCEGGDLRR--VLNRVE-NCSGLREQ A_aegypti_AAEL010548-PA GFVTLWKNH--KTNEM-----CHILLDKS-EMTDKNCERWCNEVSLMMN---KVRNENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVS-SCSGLKEL D_melanogaster_FBpp0082690 GLVIHWRNR--TTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQ---FKNFPHIVAGV----DIEDPDFLEYLNGM-FSA-KLPVIVLEYCNGGDVRK--RLQSPE-NANGLTEF A_aegypti_AAEL005359-PA GAVFQGVNK--HNGEPVAVKTFNQLSHM------RPPDVQMREFEVL-R---KVKHDNIVKLL----DIE-----DD-----QEG-RGKVIVMELCTGGSLFN--ILDDPE-NTYGLPQR A_gambiae_AGAP009565-PA GAVFQGVNK--HNGEPVAVKTFNQLSHM------RPQDVQMREFEVL-R---KVNHNNIVKLL----DIE-----DD-----QEG-RGKVIVMELCTGGSLFN--ILDDPE-NTYGLPQK A_carolinensis_ENSACAP00000012863 ASVYKARNK--ISGELVAVKVFNSVSYL------RPQEVQIREFEVL-R---KLNHQNIVKLF----SVE-----EI-----EIS-KQKVLVMEYCSGGSLLS--LLEEPE-NAFGLSES C_intestinalis_ENSCINP00000011687 GFVFKGREK--KTGQEYAIKVFNSLNYMA-----RSLEARRREFEVL-R---KVDHKNVVRLF----SVE-----EE-----LTT-KHDVIIMELCPNGSLYS--MLDDPE-NLYGLPES D_rerio_ENSDARP00000014302 ANVYKARNK--KTGELVAVKVFNLVSYN------RPYEVQMREFEVL-Q---LLNHVNIVKLF----AVE-----EI-----ISNPKQKILVMEYCSGGSLLN--MLEQPE-HAFGLPES D_rerio_ENSDARP00000074566 ANVYKARNK--KTGELVAVKVFNLVSYN------RPYEVQMREFEVL-Q---LLNHVNIVKLF----AVE-----EI-----ISNPKQKILVMEYCSGGSLLN--MLEQPE-HAFGLPES D_melanogaster_FBpp0080920 GSVFQGVNK--ITGESVAVKTFNPYSHM------RPADVQMREFEAL-K---KVNHENIVKLL----AIE-----ED-----QEG-RGKVIVMELCTGGSLFN--ILDDPE-NSYGLPEH D_rerio_ENSDARP00000087779 --------Q--KTGDLYAVKVFNNLSFL------RPLDVQMREFEVL-K---KLNHKNIVKLF----AVE-----EE-----SNT-RHKVLVMEYCPCGSLYT--VLEEPT-NAYGLPED T_nigroviridis_ENSTNIP00000005945 ANVYRGRHK--KTGDLYAVKVFNNLSFL------RPLDVQMREFEVL-K---KLNHKNIVKLF----AVE-----EE-----SNT-RHKVLVMEYCPCGSLYT--VLEESS-NAYGLPED H_sapiens_ENSP00000356087 ASVYKARNK--KSGELVAVKVFNTTSYL------RPREVQVREFEVL-R---KLNHQNIVKLF----AVE-----ET-----GGS-RQKVLVMEYCSSGSLLS--VLESPE-NAFGLPED P_pygmaeus_ENSPPYP00000000308 ASVYKARNK--KSGELVAVKVFNTTSYL------RPREVQVREFEVL-R---KLNHQNIVKLF----AVE-----ET-----GGS-RQKVLVMEYCSSGSLLS--VLESPE-NAFGLPED G_aculeatus_ENSGACP00000000783 ANVYRGRHK--KTGDLYAVKVFNNLSFL------RPLDVQMREFEVL-K---KLNHKNIVKLF----AVE-----EE-----SNT-RHKVLVMEYCPCGSLYT--VLEESS-NAYGLPED T_rubripes_ENSTRUP00000005087 ASVYKARNK--KSGELVAVKVFNTMSYN------RPHDVQMREFEML-R---KLNHSNIVRLY----AVE-----EL-----PS--KQKILVMEYCSGGSLLT--VLEEPE-NAFGLPET M_mulatta_ENSMMUP00000038190 ASVYKARNK--KSGELVAVKVFNTTSYL------RPREVQVREFEVL-R---KLNHQNIIKLF----AVE-----ET-----GGS-RQKVLVMEYCSSGSLLS--VLESPE-NAFGLPED O_latipes_ENSORLP00000019746 -----------RSGELVAVKVFNVLSYN------RPHDVQMREFEML-R---KLNHSNIVRLL----AVE-----EL-----PS--RHKVLVMEFCSGGSLLN--LLEEPE-NAFGLPET O_cuniculus_ENSOCUP00000010441 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES P_pygmaeus_ENSPPYP00000005386 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES M_mulatta_ENSMMUP00000010063 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES P_troglodytes_ENSPTRP00000008798 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES E_caballus_ENSECAP00000018587 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLVMEFCPCGSLYT--VLEEPS-NAYGLPES B_taurus_ENSBTAP00000046540 ASVYKARNK--KSGELVAVKVFNTASYL------RPREVQVREFEVL-R---KLNHQNIIKLF----AVE-----ET-----GAG-RQKVLVMEYCSSGSLLS--VLESPE-NAFGLPED H_sapiens_ENSP00000329967 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES C_familiaris_ENSCAFP00000000505 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES R_norvegicus_ENSRNOP00000009260 ANVFRGRHK--KTGDLYAVKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES M_musculus_ENSMUSP00000020316 ANVFRGRHK--KTGDLYAVKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES A_carolinensis_ENSACAP00000003243 ANVFRGRHK--KTGDLYAVKVFNNFSFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTS-RHKVLVMEFCPCGSLYT--VLEEPS-NAYGLPET E_caballus_ENSECAP00000000587 ASVYKARNK--KSGELVAVKVFNTASYM------RPREVQVREFEVL-R---KLNHQNIVKLF----AVE-----ET-----GGS-RQKVLVMEYCSSGSLLS--VLESPE-NAFGLPED T_guttata_ENSTGUP00000006693 ANVFRGRQK--KTGDLYAVKVFNSISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLVMEFCPCGSLYT--VLEEPS-NAFGLPES X_tropicalis_ENSXETP00000015947 ANVYRGRNK--KTGDLYAVKVFNNLSFL------RPADVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----MSS-RHKVLVMEFCPCASLYS--VLEEPA-NAYGLPES M_domestica_ENSMODP00000002458 ASVYRARNK--KSGELVAVKVFNNASYL------RPREVQVREFEVL-R---KLKHENIVKLF----AVE-----ET-----GSN-KQKVLVMEYCSSGSLLS--VLESPE-NAFGLSEA B_taurus_ENSBTAP00000023134 ANVFRGRHK--KTGDLFAIKVFNNISFL------RPVDVQMREFEVL-K---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLIMEFCPCGSLYT--VLEEPS-NAYGLPES G_gallus_ENSGALP00000021757 ACVYKARSK--KSGELVAVKVFNKASYL------RPQEVQMREFEML-R---KLNHKNIVKLF----AVE-----ET-----GSS-KQKVLVMEYCSSGSLLS--ILEDPA-NAFGLAEP G_gallus_ENSGALP00000015982 ANVFRGRHK--KTGDLYAVKVFNSISFL------RPVDVQMREFEVL-T---KLNHKNIVKLF----AIE-----EE-----TTT-RHKVLVMEFCPCGSLYT--VLEEPS-NAFGLPES R_norvegicus_ENSRNOP00000030127 ANVYKARNK--KSGEVVAVKVFNSASYR------RPPEVQVREFEVL-R---RLDHENIVKLF----AVE-----ET-----GGS-RQKVLVMEYCSSGSLLS--VLEDPE-NTFGLPEE X_tropicalis_ENSXETP00000017637 AKVYLAKHK--HTKETVAIKALKKEGITST----LDAERIHLEKNIL-ELATREQNPFLVGLF----ASF------------QTE-HHLCLAIDYCAGGDLYK--QVEEGP-----FPQE M_musculus_ENSMUSP00000054126 ASVYKARNK--KSGEVVAVKVFNSASYR------RPPEVQVREFEVL-R---RLNHQNIVKLF----AVE-----ET-----GGS-RQKVLIMEYCSSGSLLS--VLEDPE-NTFGLSEE D_rerio_ENSDARP00000036490 GEVKLAIEK--ETFKKVALKTINKHDFPSIG---TATRNAEREIEIL-K---KIDHPCLIKTE----DFY------------QTE-DSYYIVLEYIEGGELFG--RIKAKK-K---LEED O_anatinus_ENSOANP00000008566 ASVYKARNK--KSGELVAVKVFNNASYH------RPPEVQVREFEVL-R---KLKHQNIIKLF----AVE-----ET-----GNS-KQKVLVMEYCARGSLLT--VLEEPE-NAFGLPEE C_elegans_Y60A3A.12 GKVLLGYKK--SDRSVVAIKQLNTQFSTRCSRAIAKTRDIRNEVEVM-K---KLSHPNIVAIY----DWI------------TVA-KYSYMVIEYVGGGEFFS--KVVDSKYNRMGLGES C_elegans_T08D2.7 GKVLLGYKK--SDRSVVAIKQLNTQFSTRCSRAIAKTRDIQNEVEVM-K---KLSHPNIVAIY----DCI------------TVA-KYSYMVIEYVGGGEFFS--KLVDSKYNQMGLGES R_norvegicus_ENSRNOP00000020214 GEVCACQVR--ATGKMYACKKLEKKRIKKR----KGEAMALNEKQIL-E---KVNSRFVVSLA----YAY------------ETK-DALCLVLTLMNGGDLKF--HIYHMG-Q-AGFPEA O_latipes_ENSORLP00000008832 GRVMLVKHK--ETGQHFAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVSFPFLVQLE----HSF------------KDT-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP B_taurus_ENSBTAP00000010492 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSRFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFEEE T_rubripes_ENSTRUP00000010568 GIVCIAEER--ESGRQVAVKMMDLRKQQ-------RRELLFNEVVIM-R---DYHHQNVVQMY----RSA------------LVG-EELWVIMEYLQGGALTH--IICQTR-----LNEE R_norvegicus_ENSRNOP00000024227 SEVMLAQER--GSAHLVALKCIPKKALR------GKEALVENEIAVL-R---RISHPNIVALE----DVH------------ESP-SHLYLAMELVTGGELFD--RIMERG----SYTEK M_musculus_ENSMUSP00000110117 SEVMLAQER--GSAHLVALKCIPKKALR------GKEALVENEIAVL-R---RISHPNIVALE----DVH------------ESP-SHLYLAMELVTGGELFD--RIMERG----SYTEK M_mulatta_ENSMMUP00000008885 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED M_musculus_ENSMUSP00000005164 GRVMLVKHK--ATEQYYAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVEFPFLVRLE----YSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP T_nigroviridis_ENSTNIP00000012244 GVVYEATHI--ETQTKWAIKEICRPEAGS-----WKVKMVEHEIDIL-R---HVNHAHIIHLQ----EVY------------HTS-KMIYLVTELCVGGELKQ--LLLQKK-F---FSED P_pygmaeus_ENSPPYP00000014729 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED T_nigroviridis_ENSTNIP00000013350 GRVMLVKHK--ETGQHFAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVNFPFLVCLE----HSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP H_sapiens_ENSP00000295709 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED R_norvegicus_ENSRNOP00000043572 GRVMLVKHK--ATEQYYAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVEFPFLVRLE----YSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP P_troglodytes_ENSPTRP00000022091 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED P_pygmaeus_ENSPPYP00000003153 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSQFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFEEE M_mulatta_ENSMMUP00000006107 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSQFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFEEE H_sapiens_ENSP00000358104 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSQFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFEEE P_troglodytes_ENSPTRP00000005279 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSQFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFEEE O_cuniculus_ENSOCUP00000001738 GRVYKGRKK--YSAQVVALKFIPKLGRSE-----KELKNLQREMEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED B_taurus_ENSBTAP00000038069 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED C_familiaris_ENSCAFP00000017912 GEVCACQVR--ATGKMYACKRLEKKRIKKR----KGESMALNEKQIL-E---KVNSQFVVNLA----YAY------------ETK-DALCLVLTIMNGGDLKF--HIYNMG-N-PGFDEE E_caballus_ENSECAP00000008449 GRVYKGRRK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLRHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED B_taurus_ENSBTAP00000053464 GEVCACQVR--ATGKMYACKKLEKKRIKKR----KGEAMALNEKQIL-E---KVNSRFVVSLA----YAY------------ETK-DALCLVLTLMNGGDLKF--HIYHMG-Q-AGFPEA M_musculus_ENSMUSP00000084430 GRVYKGRKK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLWHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPED R_norvegicus_ENSRNOP00000022839 GRVYKGRKK--YSAQVVALKFIPKLGRSE-----KELRNLQREIEIM-R---GLWHPNIVHML----DSF------------ETD-KEVVVVTDYAE-GELFQ--ILEDDG-K---LPEE G_gallus_ENSGALP00000014351 GRVMMVKHK--ATEQYYAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVNFPFLVKLE----YSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP T_guttata_ENSTGUP00000006845 GRVMMVKHK--STEQYYAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVNFPFLVKLE----YSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP C_elegans_ZK909.2c GRVMLVKHK--QSGNYYAMKILDKQKVVKL----KQVEHTLNEKRIL-Q---AIDFPFLVNMT----FSF------------KDN-SNLYMVLEFISGGEMFS--HLRRIG-R---FSEP M_musculus_ENSMUSP00000001115 GEVCACQVR--ATGKMYACKKLEKKRIKKR----KGEAMALNEKQIL-E---KVNSRFVVSLA----YAY------------ETK-DALCLVLTLMNGGDLKF--HIYHMG-Q-AGFPEA B_taurus_ENSBTAP00000001970 GEVCACQVR--ATGKMYACKKLEKKRIKRR----KGEAMALSEKRIL-E---KVHSRFVVSLC----YTY------------QTK-KSLCLVLTIMNGGDLKF--HIHNLG-D-PGFEEQ A_carolinensis_ENSACAP00000005713 GRVMLVKHK--ATEQYYAMKILDKQKVVKL----KQIEHTLNEKRIL-Q---AVNFPFLVRLE----YSF------------KDN-SNLYMVMEYVPGGEMFS--HLRRIG-R---FSEP A_aegypti_AAEL007931-PA GTVCIATDK--STGRQVAVKKMDLRKQQ-------RRELLFNEVVIM-R---DYHHPNIVETY----SSF------------LVN-DELWVVMEYLEGGALTD--IVTHSR-----MDEE G_aculeatus_ENSGACP00000018211 GVVCIARER--SSGRQVAVKMMDVRRQQ-------RRELLFNEVVIM-R---EYRHHNVVEMF----GSA------------LVE-EELWVIMEYLQGGALTH--IVSKTR-----LEEE G_aculeatus_ENSGACP00000000485 ASVYKARNK--RLGELVAVKVFNSVSYN------RPHEVQMREFEML-R---RLKHSNIVRLY----AVE-----EL-----PS--KQNVLVMEYCSGGSLLS--LLEESE-NAFGLPET M_domestica_ENSMODP00000006295 SEVILAEEK--TTHKLVAIKCIAKKALE------GKESSIENEIAVL-H---KIKHPNIVALD----DIY------------ECG-GHLYLIMQLVSGGELFD--RIVEKG----FYTER A_gambiae_AGAP010874-PA GTVCIATDK--STGRQVAVKQMDLRKQQ-------RRELLFNEVVIM-R---DYHHPNIVETY----SSF------------LVN-DELWVVMEFLEGGALTD--IVTHSR-----MDEE 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA P_troglodytes_ENSPTRP00000055512 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA M_mulatta_ENSMMUP00000024306 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA C_familiaris_ENSCAFP00000014093 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIMHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA B_taurus_ENSBTAP00000009985 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIMHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA P_pygmaeus_ENSPPYP00000002975 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA R_norvegicus_ENSRNOP00000034134 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIMHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA M_musculus_ENSMUSP00000026217 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKTIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA E_caballus_ENSECAP00000005937 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIMHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA M_domestica_ENSMODP00000013213 QILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDV----GGKVIHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIV G_gallus_ENSGALP00000005196 QILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE----GGKIIHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKS--YSVTVDYWSFGTMVFECIA O_anatinus_ENSOANP00000003934 QILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQNV----DGKVIHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFEGIV T_guttata_ENSTGUP00000004836 QILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE----GGKIVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKS--YSVTVDYWSFGTMVFECIA A_carolinensis_ENSACAP00000011973 QILNLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE----GGKIIHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFD--------NKP--YTASVDFWSFGTVVFECIT X_tropicalis_ENSXETP00000038296 QVLNLMSDI--GSGIQYLHEK-RII--HRDLKPENIVLQEC----NGKTVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YSVTVDYWSFGTMVFECIA T_rubripes_ENSTRUP00000022821 EVLSLINDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI----SGKLVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTVTVDYWSFGTMLFECSC D_rerio_ENSDARP00000013115 EVLSLLNDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI----NGKLVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------GKS--YTVTVDFWSFGTMIFECCC T_nigroviridis_ENSTNIP00000014802 EVLSLLNDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI----SGKLVHKIIDLGYAKD---LD-QGSLCTSFVGTVQYLAPELFE--------NKP--YTVTVDYWSFGTMLFECSC O_latipes_ENSORLP00000016017 EVLSLLSDV--GSGIQYLHEN-KII--HRDLKPENIVLQ---------LVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTVTVDYWSFGTMIFECSC G_aculeatus_ENSGACP00000005520 EVLSLLNDV--GSGIQYLHEN-KII--HRDLKPENIVLQDI----NGKLVHKIIDLGYAKD---LD-QDSLCTSFVGTLQYLAPELFE--------NHP--YTVTVDYWSFGTMMFECIC G_aculeatus_ENSGACP00000008884 EVLSLLSDIDAGSGIQYLHEN-KII--HRDLKPENIVLQEI----GGKLIHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------SKP--YTVTVDYWSFGTVIFECTC T_rubripes_ENSTRUP00000036336 EVFSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEV----DGKLVHKLIDLGYAKD---LD-QGSLCTSFVGTIQYLAPELFE--------NKP--YTVTVDYWSFGTVIFECIC G_gorilla_ENSGGOP00000008804 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKIIHKIIDLGYAKD---VD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTATVDYWSFGTMVFECIA O_latipes_ENSORLP00000011761 EVLSLLKDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI----DGKLVHKIIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------SKP--YTVSVDYWSLGTVLFECIC T_nigroviridis_ENSTNIP00000019642 EVLSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEN----DGKLVHKLIDLGYAKD---LD-QGSLCTSFVGTLQYLAPELFE--------NKP--YTVTVDYWSFGTVIFECIC M_mulatta_ENSMMUP00000010949 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT H_sapiens_ENSP00000339151 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT M_musculus_ENSMUSP00000033939 AVLTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT C_familiaris_ENSCAFP00000008270 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT A_carolinensis_ENSACAP00000012680 AILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EERLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT R_norvegicus_ENSRNOP00000025851 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT G_gallus_ENSGALP00000005924 AILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT O_anatinus_ENSOANP00000001111 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----QQRLIHKIIDLGYAKE---LD-QSSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT P_troglodytes_ENSPTRP00000034602 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT O_latipes_ENSORLP00000003067 SVLILLRDI--SSALTYLHNK-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKE---LD-QSSLCTSFVGTLQYLAPELIE--------RMQ--YTVTVDYWSFGTLVFECIT B_taurus_ENSBTAP00000049055 AILTLLSDI--ASALRYLHEN-NHIVNHPKMQESDNLSEVG----EFKLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT M_domestica_ENSMODP00000012792 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT X_tropicalis_ENSXETP00000036619 PILTLLSDI--SSALRYLHEN-RII--HRDLKPENIVLQPG----PQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QKK--YTVTVDYWSFGTLAFECIT P_pygmaeus_ENSPPYP00000020804 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT O_cuniculus_ENSOCUP00000011297 QILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV----GGKXXXXXXXXXXXXX---XX-XXXXXXXXXXXXXXXXXXXXX--------XXX--XXXXXXXXXXXXXXXXXXX G_aculeatus_ENSGACP00000005440 SVLILLRDI--SSALTYLHKK-RII--HRDLKPENIVLQHG----EKRLIHKIIDLGYAKE---LD-QSSLCTSFVGTLQYLAPELIE--------REK--YTVTVDYWSFGTLVFECIT T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 SVLILLCDI--SSALSYLHKK-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKQ---LD-HSSLCVSFVGTLQYLAPELIE--------RQK--YTVTVDYWSFGTLVFECIT E_caballus_ENSECAP00000003662 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT T_rubripes_ENSTRUP00000041917 SVLILLCDI--SSALTYLHKK-RII--HRDLKPENIVLQQG----EKRLIHKIIDLGYAKQ---LD-QSSLCTSFVGTLQYLAPELIE--------RQM--YTVTVDYWSFGTLVFECIT G_gorilla_ENSGGOP00000006628 AILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT O_cuniculus_ENSOCUP00000006175 XXXXXXXXX--XSALRYLHEN-RII--HRDLKPENIVLQQG----EQRXXXXXXXXXXXXX---XX-XXXXXXXXXXXXXXXAPELLE--------QQK--YTVTVDYWSFGTLAFECIT T_guttata_ENSTGUP00000005662 AILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG----EQRLIHKIIDLGYAKE---LD-QGSLCTSFVGTLQYLAPELLE--------QQK--YTVTVDYWSFGTLAFECIT A_aegypti_AAEL003245-PA EVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM----GDRMVYKLTDLGYAKA---LD-KQSLNASLVGTVEYIAPDLIY--------CDR--YNCSVDYWSMGIIAFEIIC A_gambiae_AGAP009166-PA DVRDVLRSL--RSAIAYLHSL-KIT--HRDIKPENLVLKQH----GDRFIYKLTDLGYAKA---LD-KQSLNASLVGTVEYIAPDLIY--------CDR--YNCSVDYWSMGVIGFEIVT A_aegypti_AAEL010548-PA EVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM----GDRMVYKLTDLGYAKA---LD-KQSLNASLVGTVEYIAPDLIY--------CDR--YNCSVDYWSMGIIAFEIIC D_melanogaster_FBpp0082690 EVRQILGAL--RKALHFLHSQCGIC--HRDLKPDNIVIQRG---VDGKKIYKLTDFGLARG---TP-DQTMVQSVVGTRHYYAPEVVE--------NGF--YNSTVDLWSFGVIAYELVT A_aegypti_AAEL005359-PA EFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYIS---EDGKTIYKLTDFGAARE---LE-ENQQFVSLYGTEEYLHPDMYERAVLRKSINRS--FTANVDLWSIGVTLYHVAT A_gambiae_AGAP009565-PA EFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYIS---EDGQTVYKLTDFGAARE---LG-ENQQFASLYGTEEYLHPDMYERAVLRKSINRS--FTANVDLWSIGVTLYHVAT A_carolinensis_ENSACAP00000012863 EFLIVLHCV--VSGMNHLREN-GIV--HRDIKPGNIMRLTS---EDRQSIYKLSDFGAARE---LD-DDEKFESVYGTEEYLHPDIYKRAVLKKPQQKA--YGVTVDLWSIGVTFYHAAT C_intestinalis_ENSCINP00000011687 EFHRVLSHI--TAGMKHLHDK-GIV--HRDLKPGNIMRSLD---DDGTAVYKLTDFGAARE---LG-DDEQFMSLYGTEEYLHPDIYERAVLRKHAGKM--FSATVDLWSLGVTLYHVAT D_rerio_ENSDARP00000014302 EFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVG---EDGRSVYKLADFGAARE---LE-DDEKFVSIYGTEEYLHPHMYERAVLRIPQQKA--YGVSVDLWSIGVTIYHMAT D_rerio_ENSDARP00000074566 EFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVG---EDGRSVYKLADFGAARE---LE-DDEKFVSIYGTEEYLHPHMYERAVLRSPQQKA--YGVSVDLWSIGVTIYHMAT D_melanogaster_FBpp0080920 EFLLVLEHL--CAGMKHLRDN-KLV--HRDLKPGNIMKFIS---EDGQTIYKLTDFGAARE---LE-DNQPFASLYGTEEYLHPDLYERAVLRKSIQRS--FTANVDLWSIGVTLYHVAT D_rerio_ENSDARP00000087779 EFLIVLQDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIG---DDGFSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT T_nigroviridis_ENSTNIP00000005945 EFLIVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIG---EDGRSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT H_sapiens_ENSP00000356087 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVG---EEGQSIYKLTDFGAARE---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT P_pygmaeus_ENSPPYP00000000308 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVG---EEGQSIYKLTDFGAARE---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT G_aculeatus_ENSGACP00000000783 EFLLVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIG---EDGRSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT T_rubripes_ENSTRUP00000005087 EFLTVLQCV--VRGMNHLREN-GVV--HRDIKPGNIMRQAG---EDGKSVYKLTDFGAARE---LE-DDEKFISIYGTEEYLHPDMYERAVLRKPHQKS--YGVSVDLWSIGVTFYHAAT M_mulatta_ENSMMUP00000038190 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVG---EEGQSIYKLTDFGAARE---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT O_latipes_ENSORLP00000019746 EFLTVLQCI--VQGMNHLREN-GVV--HRDIKPGNILRQVG---EDGKSIYKLTDFGAARE---LE-DDEKFVSIYGTEEYLHPDMYERAVLRKHHQKT--YGVSVDLWSIGVTLYHSAT O_cuniculus_ENSOCUP00000010441 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT P_pygmaeus_ENSPPYP00000005386 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT M_mulatta_ENSMMUP00000010063 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT P_troglodytes_ENSPTRP00000008798 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT E_caballus_ENSECAP00000018587 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT B_taurus_ENSBTAP00000046540 EFLVVLRCV--AAGMNHLREN-GIV--HRDIKPGNIMRLLG---EEGQSIYKLTDFGAARE---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT H_sapiens_ENSP00000329967 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT C_familiaris_ENSCAFP00000000505 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT R_norvegicus_ENSRNOP00000009260 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSVGVTFYHAAT M_musculus_ENSMUSP00000020316 EFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSVGVTFYHAAT A_carolinensis_ENSACAP00000003243 EFLIVLKDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LD-DDEQFVSLYGTEEYLHPDMYERAVLRKEHQKK--YGATVDLWSIGVTFYHAAT E_caballus_ENSECAP00000000587 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLG---EEGQSIYKLTDFGAARE---LD-DDEKFISVYGTEEYLHPDMYERAVLRKPQQKA--FGVAVDLWSIGVTLYHAAT T_guttata_ENSTGUP00000006693 EFLIVLRDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKEHQKK--YGATVDLWSIGVTFYHAAT X_tropicalis_ENSXETP00000015947 EFLIVSRDV--VAGMNHLREN-GII--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LD-DDEQFVSLYGTEEYLHPDMYERAVLRKEHQKK--YGATVDLWSIGVTFYHAAT M_domestica_ENSMODP00000002458 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLG---EDGQSIYKLTDFGAARE---LE-DDEKFVSVYGTEEYLHPDVYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT B_taurus_ENSBTAP00000023134 EFLIVLRDV-EVGGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT G_gallus_ENSGALP00000021757 EFLVVLQCV--VAGMNHLREN-GVV--HRDIKPGNIMRLVG---EDGQSIYKLTDFGAARE---LE-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--YGVTVDLWSIGVTFYHAAT G_gallus_ENSGALP00000015982 EFLIVLRDVVKVAGMNHLREN-GIV--HRDIKPGNIMRVIG---EDGQSVYKLTDFGAARE---LE-DDEQFVSLYGTEEYLHPDMYERAVLRKEHQKK--YGATVDLWSIGVTFYHAAT R_norvegicus_ENSRNOP00000030127 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVG---KEGQSIYKLSDFGAARK---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT X_tropicalis_ENSXETP00000017637 KAVFYAGCI--VLGLQFLHKN-NII--HRDIKPENILIAS-------DGYTKITDFGLAKK---TETYGGITNTFCGTRYYMAPEIVK--------KDC--HTKSVDWWALGIVIYEMIR M_musculus_ENSMUSP00000054126 EFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVG---EEGQSIYKLSDFGAARK---LD-DDEKFVSVYGTEEYLHPDMYERAVLRKPQQKA--FGVTVDLWSIGVTLYHAAT D_rerio_ENSDARP00000036490 IAKLYFYQM--LKAVEYLHNN-GII--HRDLKPENVLLASH----DDICLIKITDFNQSKI---LE-ESSLMKTLCGTPTYVAPEVFTHAS-----TVG--YTKAVDYWSLGVLLFICLG O_anatinus_ENSOANP00000008566 EFLVVLQCV--VAGINHLREN-GIV--HRDIKPGNIMRLVG---EAGQSIYKLTDFGAARE---LA-DDEKFVSVYGTEEYLHPDVYERAVLKKPQQKA--FGVTVDLWSIGVTFYHAAT C_elegans_Y60A3A.12 LGKYFAFQL--IDAILYLHSV-GIC--HRDIKPENILCSDK----AERCILKLTDFGMAKN------SVNRMKTRCGTPSYNAPEIVA--------NEGVEYTPKVDIWSLGCVLFITFS C_elegans_T08D2.7 LGKYFAFQL--IDAVLYLHSV-GIC--HRDIKPENILCSNK----AERCILKLTDFGMAKN------SVNRMKTHCGTPSYCAPEIVA--------NQGVEYTPKVDIWSLGCVLFITFS R_norvegicus_ENSRNOP00000020214 RAVFYAAEI--CCGLEDLHRE-RIV--YRDLKPENILLDD-------HGHIRISDLGLAVH---VP-EGQTIKGRVGTVGYMAPEVVK--------NER--YTFSPDWWALGCLLYEMIA O_latipes_ENSORLP00000008832 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDQ-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA B_taurus_ENSBTAP00000010492 RALFYAAEI--LCGLEDLHHE-NIV--YRDLKPENILLDD-------YGHIRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE T_rubripes_ENSTRUP00000010568 QIATVCEGV--LQALTYLHSQ-GVI--HRDIKSDSILLTL-------DGRIKLSDFGFCAQ---ISKDVPKRKSLVGTPYWMAPEVIA--------KSP--YGPEVDIWSLGIMVVEMVD R_norvegicus_ENSRNOP00000024227 DASHLVGQV--LGAVSYLHSL-GIV--HRDLKPENLLYATP----FEDSKIMVSDFGLSK----IQ-AGNMLGTACGTPGYVAPELLE--------QKP--YGKAVDVWALGVISYILLC M_musculus_ENSMUSP00000110117 DASHLVGQV--LGAVSYLHSL-GIV--HRDLKPENLLYATP----FEDSKIMVSDFGLSK----IQ-AGNMLGTACGTPGYVAPELLE--------QKP--YGKAVDVWALGVISYILLC M_mulatta_ENSMMUP00000008885 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV M_musculus_ENSMUSP00000005164 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDH-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA T_nigroviridis_ENSTNIP00000012244 ETKHIICCL--ADAVDYLYKR-NIV--HRDLKLENILVKNAIVDNNDKIIIKVTDFGLSVQTYGLG-IDHILTESCGTLTYMAPEIMS--------GRG--YSHWCDMWSMGVIIYIMLC P_pygmaeus_ENSPPYP00000014729 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV T_nigroviridis_ENSTNIP00000013350 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDQ-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA H_sapiens_ENSP00000295709 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV R_norvegicus_ENSRNOP00000043572 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDH-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA P_troglodytes_ENSPTRP00000022091 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV P_pygmaeus_ENSPPYP00000003153 RALFYAAEI--LCGLEDLHRE-NTV--YRDLKPENILLDD-------YGHIRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE M_mulatta_ENSMMUP00000006107 RALFYAAEI--LCGLEDLHRE-NTV--YRDLKPENILLDD-------YGHIRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE H_sapiens_ENSP00000358104 RALFYAAEI--LCGLEDLHRE-NTV--YRDLKPENILLDD-------YGHIRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE P_troglodytes_ENSPTRP00000005279 RALFYAAEI--LCGLEDLHRE-NTV--YRDLKPENILLDD-------YGHIRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE O_cuniculus_ENSOCUP00000001738 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV B_taurus_ENSBTAP00000038069 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV C_familiaris_ENSCAFP00000017912 RALFYAAEI--LCGLEDLHRE-NTV--YRDLKPENILLDD-------YGKLRISDLGLAVK---IP-EGDLIRGRVGTVGYMAPEVLN--------NQR--YGLSPDYWGLGCLIYEMIE E_caballus_ENSECAP00000008449 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV B_taurus_ENSBTAP00000053464 RAVFYAAEI--CCGLEDLHRE-RIV--YRDLKPENILLDD-------HGHIRISDLGLAVH---VP-EGQTIKGRVGTVGYMAPEVVK--------NER--YTFSPDWWALGCLLYEMIA M_musculus_ENSMUSP00000084430 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV R_norvegicus_ENSRNOP00000022839 QVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLAK-------GGGIKLCDFGFARA---MSTNTMVLTSIKGTPLYMSPELVE--------ERP--YDHTADLWSVGCILYELAV G_gallus_ENSGALP00000014351 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDQ-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA T_guttata_ENSTGUP00000006845 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDQ-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA C_elegans_ZK909.2c HSRFYAAQI--VLAFEYLHSL-DLI--YRDLKPENLLIDS-------TGYLKITDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA M_musculus_ENSMUSP00000001115 RAVFYAAEI--CCGLEDLHRE-RIV--YRDLKPENILLDD-------HGHIRISDLGLAVH---VP-EGQTIKGRVGTVGYMAPEVVR--------NER--YTFSPDWWALGCLLYEMIA B_taurus_ENSBTAP00000001970 RAIFYAAEL--CCGLEDLQRE-RIV--YRDLKPENILLDD-------YGHIRISDLGLALE---IP-EGAKISGRVGTLGYMAPEVIN--------SES--YTFSPDWWGLGCLIYEMIE A_carolinensis_ENSACAP00000005713 HARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLIDQ-------QGYIQVTDFGFAKR---VK---GRTWTLCGTPEYLAPEIIL--------SKG--YNKAVDWWALGVLIYEMAA A_aegypti_AAEL007931-PA QIATVCKQC--LKALSYLHSQ-GVI--HRDIKSDSILLAS-------DGRVKLSDFGFCAQ---VSQELPKRKSLVGTPYWMSPEVIS--------RLP--YGPEVDIWSLGIMVIEMID G_aculeatus_ENSGACP00000018211 QTATVCHSV--LEALSYLHSQ-GVV--HRDIKSDSILLSV-------DGTIKLSDFGFCAQ---ISREVPKRRSLVGTPYWMAPEVIS--------KTP--YGTEVDIWSLGIMVVEMVD G_aculeatus_ENSGACP00000000485 EFLIVLQCV--VQGMNHLREN-GVV--HRDIKPGNIMRQVG---EDGKSVYKLTDFGAARV---LE-DDEKFMSIYGTEEYLHPDMYERAVLRKPHQKS--YGVSVDLWSIGVTFYHAAT M_domestica_ENSMODP00000006295 DASRLICQV--LDAVKYLHDM-GIV--HRDLKPENLLYYSL----EEDSKIMISDFGLSK----MEGSGSVLSTACGTPGYVAPEVLA--------QKP--YSKAVDCWSIGVIAYILLC A_gambiae_AGAP010874-PA QIATVCKQC--LKALSYLHSQ-GVI--HRDIKSDSILLAS-------DGRVKLSDFGFCAQ---VSQELPKRKSLVGTPYWMSPEVIS--------RLP--YGPEVDIWSLGIMVIEMID 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMSGEVRFSSH--LPQPNSL----CSLVVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R P_troglodytes_ENSPTRP00000055512 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMSGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDFTLKQP----R M_mulatta_ENSMMUP00000024306 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMSGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R C_familiaris_ENSCAFP00000014093 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R B_taurus_ENSBTAP00000009985 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R P_pygmaeus_ENSPPYP00000002975 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMSGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R R_norvegicus_ENSRNOP00000034134 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNNL----CSLIVEPMESWLQLMLNWDPQQRGG-----------------PIDPPLKQP----K M_musculus_ENSMUSP00000026217 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNSL----CSLIVEPMESWLQLMLNWDPQQRGG-----------------PIDLTLKQP----R E_caballus_ENSECAP00000005937 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNSL----CSLIVEPMEHWLQLMLNWDPQQRGG-----------------PVDLTLKQP----R M_domestica_ENSMODP00000013213 GYRPFLHHLQ--PF---TWHE---KIKKKDPKHIF--AFEEMTGEVRFSSH--LPQPNSL----SSFIVQPMEQWLQLMLTWDPQQRGG-----------------SLDLPHKQP----A G_gallus_ENSGALP00000005196 GFRPFLHNLQ--PF---TWHE---KIKKKDPKHIF--ASEEMNGEVRFSTH--LPQPHSI----CSLIVEPMESWLQLMLNWDPEQRGG-----------------GLDPETNSP----K O_anatinus_ENSOANP00000003934 GYRPFLHHLQ--PF---MWHE---KIKKKDPKHIF--ASEEMSGEVRFSSH--LPQPNSL----CRLIVEPMENWLQLMLNWDPQQRGG-----------------GIDSSTKQP----R T_guttata_ENSTGUP00000004836 GFRPFLHNLQ--PF---AWHE---KIKKKDPKHIF--ASEEMNGEVRFSTH--LPQPHSL----CGLIVEPMENWLQLMLNWDPQQRGG-----------------GSDAETGRP----R A_carolinensis_ENSACAP00000011973 GFRPFLHNQQ--PF---TWHD---KIKKKDPKCIF--AWEEMTGEVRFSAH--LPNPNSL----CSIIVELMESWLQLMLNWDPQQRGG-----------------GRDPETGNF----R X_tropicalis_ENSXETP00000038296 GFRPFLHNMQ--PF---TWHE---KIKKKDHKHIY--AYEEMSGEIRFSSY--LPQPNNL----CSIIVDKIETWLQLLLNWDPIQRGG-----------------GMD--CGRP----Q T_rubripes_ENSTRUP00000022821 GFRPFLHNLQ--PV---QWAS---KVRNKGPKDIM--AVEELNGEVKFSTQ--LPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG-----------------RVSPESKKP----L D_rerio_ENSDARP00000013115 GFRPFLHNLQ--PV---QWTS---KVRNKGPKDIM--AVEDMNGEVRFSTH--LPYPNNL----SRTLLEPLEGLLQLMLKWDPVQRGL-----------------GLNTDSKQP----Q T_nigroviridis_ENSTNIP00000014802 GFRPFLHNLQTSAV---LRAS---KVRNKGPKDIM--AVEELNGEVKFSTQ--LPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG-----------------RVNPETKKP----L O_latipes_ENSORLP00000016017 GFRPFLHNLQ--PV---QWAS---KVKNKGPKDIM--AVEELNGEVRFSTH--LPYPNNL----SRTLLEPMETLLQLMLKWDPVQRGG-----------------RVNSDTKKP----M G_aculeatus_ENSGACP00000005520 GFRPFLHNLQ--PV---QWAT---KVKNKGPRDIT--AVEEPNGEVTFSTH--LPYPNNL----SSTMLGPIEKLLQLMLRWDPFHRGG-----------------PVNRETKRP----S G_aculeatus_ENSGACP00000008884 GFRPFLHHMQ--PV---QWTS---KVKNKGPKDIV--AVEDMNGEVRFSTH--LPYPNNV----SRPLLEPVESLLQMLLLWDAAARGG-----------------GLDPDTNKP----H T_rubripes_ENSTRUP00000036336 GFRPFLHHMQ--PV---QWTS---KVKNKGPKDIM--ATEDMNGEVRFSAH--LHYPNNL----SRPLLEPVESLLQMLLLWDPAARGG-----------------TVDADTNKP----Y G_gorilla_ENSGGOP00000008804 GYRPFLHHLQ--PF---TWHE---KIKKKDPKCIF--ACEEMSGEVRFSSH--LPQPNSL----CXXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXX----X O_latipes_ENSORLP00000011761 GFRPFLHHMQ--PV---QWTS---KVKNKGPKDIM--AVEDMNGEVRFSAH--LPYPNNL----SSPLLEPIESLLQMLLLWDPSTRGG-----------------GLDPETNKP----Y T_nigroviridis_ENSTNIP00000019642 GFRPFLHHMQ--PV---QWTS---KVKNKGPKDIM--ATEDMNGDVRFSAH--LHYPNNL----SRPLLEPLESLLQMLLLWDPVARGG-----------------MLDTDTNKP----H M_mulatta_ENSMMUP00000010949 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPKYGPN----G H_sapiens_ENSP00000339151 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G M_musculus_ENSMUSP00000033939 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGAVKFSSS--LPFPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPQYGPN----G C_familiaris_ENSCAFP00000008270 GFRPFLPNWQ--PV---QWHS---KVRQKSEMDIV--VSEDLNGAVKFSSS--LPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----G A_carolinensis_ENSACAP00000012680 GFRPFLPNWQ--PV---QWHT---KVRQKSELDIV--VYEDLNGEVKFSSK--LPHPNNL----NSVLADRLEKWLQLMLKWHPRQRG-------------------TDPTYGTN----G R_norvegicus_ENSRNOP00000025851 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPFPNNL----NSVLAERLEKWLQLMLTWQPRQRG-------------------VDPQYGPN----G G_gallus_ENSGALP00000005924 GFRPFLPNWQ--PV---QWHT---KVRQKSELDIV--VSEDLSGEVKFSSS--LPCPNNL----NSVLAGKLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----G O_anatinus_ENSOANP00000001111 GFRPFLPNWQ--PV---QWHS---TVRQKSELDIV--VSEDLTGEVKFSSR--LPYPNNL----NRVLALRLEKWLQLMLMWQPRQRG-------------------TDHIYGPN----G P_troglodytes_ENSPTRP00000034602 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G O_latipes_ENSORLP00000003067 GFRPFLPTWQ--PV---PWHN---KVRLKENDHIV--VYEDLSGEVQFSKH--LPQPNNL----NSLLLEKMERWLQLMLMWSPQNRG-------------------KDPNATPT----D B_taurus_ENSBTAP00000049055 GFRPFLPNWQ--PV---QWHS---KVRQKSEMDIV--VSEDLNGAVKFSSS--LPHPNNL----NSVLAQRLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----G M_domestica_ENSMODP00000012792 GFRPFLPNWQ--PV---QWHS---KVRQKSELDIV--VSEDLSGGVKFSSC--LPYPNNL----NSILAQRLEKWLQLMLMWQARQRG-------------------TDPTYGPN----G X_tropicalis_ENSXETP00000036619 GFRPFLPNWQ--PV---QWHG---KVREKSNEHIV--VYEDLMGAVKFSSV--LPTPNHL----NSKLAGKLEHWLQCMLMWHQRQRG-------------------TDPQNPNV----G P_pygmaeus_ENSPPYP00000020804 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G O_cuniculus_ENSOCUP00000011297 XXXXXXXXXX--XX---XXHE---KIKKKDPKCIF--ACEEMTGEVRFSSH--LPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----K G_aculeatus_ENSGACP00000005440 GFRPFLPTWQ--PI---PWHN---KLRTKQKDDIV--VYEDLTGEVHFSKH--LPQPNDL----NSLLSERLERWLQLMLKWCPQERG-------------------KDPNATPS----D T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 GFRPFLPSWQ--PV---PWHH---KVRLKGNNDIV--VYEDLTGEVHYCKH--LPQPNNL----NSLLSGKLERWLQLMLKWSPQERG-------------------KDPEAAPN----D E_caballus_ENSECAP00000003662 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSRMGSRLCVGLECM---NCGTRA-------------------AFPKLGPC----F T_rubripes_ENSTRUP00000041917 GFRPFLPSWQ--PV---PWHN---KVMLKGDNDIV--VYENLTREVHFSKH--LPQPNNL----NSLLSLKLERWLQLMLKWSPQERG-------------------KDPGATPS----D G_gorilla_ENSGGOP00000006628 GFRPFLPNWQ--PV---QWHS---KVRQKSEVDIV--VSEDLNGTVKFSSS--LPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G O_cuniculus_ENSOCUP00000006175 GFRPFLPNWQ--PV---QWHS---KVRQKSEMDIV--VSEDLNGAVKFSSS--LPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G T_guttata_ENSTGUP00000005662 GFRPFLPNWQ--PV---QWHT---KVRQKSELDIV--VSEDLSGEVKFSSC--LPCPNNL----NSVLSGRLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----G A_aegypti_AAEL003245-PA GIRPFSPHSI--VA---KWMM---LVQQKKSSHIA--ITEDNRENYTYHSE--LFSENHI----SSVLKTYLEKWLTLALEWNPKQRGHV-FQIGDKEVTEQQLKSAKEPSNGQPVQVLK A_gambiae_AGAP009166-PA GVRPFIPHAP--IT---RWMM---HVQQKKSADIA--ITEDNRENYTYHTE--IFAENHI----STCLRKQLERWLMLALEWNPKQRGYVPYSATVAEGTPPKSVTFAEDSRPGGSTVLK A_aegypti_AAEL010548-PA GIRPFSPHSI--VA---KWMM---LVQQKKSNHIA--SLKITGR--IYHSE--LFPENHI----SSVLKTYLEKWLTLALEWNPKQRGH--------------------PSNGQPVQVLK D_melanogaster_FBpp0082690 GELPFIPHQT--LK---NIIL---NLIKKPAKCIA--ITEDPEDNTRFVNQFELPQTHHL----SRPWAAQFTKWLASPLNSNYKERG-------------------QLAANNVP----V A_aegypti_AAEL005359-PA GNLPFRPFGG---RKNKETMH---HITTKKAPGVISGTQTSENGPIEWSRH--LPPHCQL----KAGLKFLVTPLLAGLLEESQKRMWSFD----------------------------R A_gambiae_AGAP009565-PA GNLPFRPYGG---RKNKETMY---HITTKKAPGVISGTQTSENGPIEWSKH--LPAHCQL----KEGLKQLVTPLMAGLLEESQGRMWSFD----------------------------K A_carolinensis_ENSACAP00000012863 GSLPFIPFGG--PRRNKEIMY---KITTEKPTGAIAGVQEQENGAIIWTDE--LPISCQL----SLGLKRPLVPILANILEADQEECWSFD----------------------------Q C_intestinalis_ENSCINP00000011687 GMLPFRPYGG--ARRNKDVMY---RITTEKPSGVISGVQHSERGSIEWSRE--LPKTCRL----SHGFKKIFTVVLSGILECNPHKIWTFD----------------------------R D_rerio_ENSDARP00000014302 GSLPFRPFGG--PRKNKQMMH---KITTEKPAGTIAGVQKEEDGPIEWRDK--LPLSCQL----SEGLKTQLVPVLANILLADDEKCWKFP----------------------------Q D_rerio_ENSDARP00000074566 GSLPFRPFGG--PRKNKQMMH---KITTEKPAGTIAGVQKEEDGPIEWRDK--LPLSCQL----SEGLKTQLVPVLANILLADDEKCWKFP----------------------------Q D_melanogaster_FBpp0080920 GNLPFRPFGG---RKNRETMH---QITTKKASGVISGTQLSENGPIEWSTT--LPPHAHL----SQGLKTLVTPLLAGLLEENREKTWSFD----------------------------R D_rerio_ENSDARP00000087779 GSLPFRPFEG--PRRNKEVMY---KIITEKPPGAISGHQKFENGKIEWSSE--MPISCSLVCAYSRGLQSLLTPVLANILEADQEKCWGFD----------------------------Q T_nigroviridis_ENSTNIP00000005945 GSLPFRPFEG--PRRNKEVMY---KIITEKPPGTISGHQKCENGKIEWSSE--MPVSCSL----SKGLQSLLTPVLANILEADQEKCWGFD----------------------------Q H_sapiens_ENSP00000356087 GSLPFIPFGG--PRRNKEIMY---RITTEKPAGAIAGAQRRENGPLEWSYT--LPITCQL----SLGLQSQLVPILANILEVEQAKCWGFD----------------------------Q P_pygmaeus_ENSPPYP00000000308 GSLPFIPFGG--PRRNKEIMH---RITTEKPAGAIAGAQRRENGPLEWSYT--LPITCQL----SLGLQSQLVPILANILEVEQAKCWGFD----------------------------Q G_aculeatus_ENSGACP00000000783 GSLPFRPFEG--PRRNKEVMY---KIITEKPSGTISGHQKCENGKIEWSTE--MPVSCSL----SKGLQSLLTPVLANILEADQEKCWGFD----------------------------Q T_rubripes_ENSTRUP00000005087 GSLPFIPYGG--PRKNKLTMF---KITTEKPTGAISGLQRVADGSIEWSYS--LPHSCQL----SQGLKVLLVPVLAGIMEADQEKCWGFD----------------------------Q M_mulatta_ENSMMUP00000038190 GSLPFIPFGG--PRRNKEIMY---RITTEKPAGAIAGAQRRENGPLEWSYT--LPITCQL----SLGLQSQLVPILANILEVEQAKCWGFD----------------------------Q O_latipes_ENSORLP00000019746 GSLPFTPFEG--PRKNKPVMH---KITREKPIHAIAGVQRVEGGPIEWSYH--LPHSCQL----SRGLKVLLVPVLAGIMEADQERCWVFD----------------------------Q O_cuniculus_ENSOCUP00000010441 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSAD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q P_pygmaeus_ENSPPYP00000005386 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q M_mulatta_ENSMMUP00000010063 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q P_troglodytes_ENSPTRP00000008798 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q E_caballus_ENSECAP00000018587 GSLPFRPFEG--PRRNKEVMY---KILTGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q B_taurus_ENSBTAP00000046540 GSLPFVPFGG--PRRNKEIMY---RITTEKPAGAIAGTQRRENGPLEWSYT--LPITCQL----SMGLQSQLVPILANILEVEQAKCWGFD----------------------------Q H_sapiens_ENSP00000329967 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q C_familiaris_ENSCAFP00000000505 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSRD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q R_norvegicus_ENSRNOP00000009260 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPLSCSL----SQGLQALLTPVLANILEADQEKCWGFD----------------------------Q M_musculus_ENSMUSP00000020316 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPLSCSL----SQGLQALLTPVLANILEADQEKCWGFD----------------------------Q A_carolinensis_ENSACAP00000003243 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIEWSRE--MPVSCSL----SKGLQVLLTPVLANILEADQEKCWGFD----------------------------Q E_caballus_ENSECAP00000000587 GSLPFVPFGG--PRRNKEIMY---RITTEKPAGAIAGTQRRENGPLEWSYS--LPITCRL----SSGLQSQLVPILANILEVEQAKCWGFD----------------------------Q T_guttata_ENSTGUP00000006693 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGIQKAENGPIEWSWE--MPVSCSL----SKGLQVLLTPVLANILEADQEKCWGFD----------------------------Q X_tropicalis_ENSXETP00000015947 GSLPFRPFEG--PRRNKEVMY---KIIAGKPSGAISGVQRAENGPIEWSGE--LPVTCNL----SMGLQTLFTPVLANILEADQEKCWGFE----------------------------Q M_domestica_ENSMODP00000002458 GSLPFVPFGG--PRRNKEIMYARDQGGKERLAAVCPGTQKRENGPLEWSYK--LPITCRL----SLGLQAQLVPILASILEVDQEKCWGFD----------------------------Q B_taurus_ENSBTAP00000023134 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGVQKAENGPIDWSGD--MPVSCSL----SRGLQVLLTPVLANILEADQEKCWGFD----------------------------Q G_gallus_ENSGALP00000021757 GRLPFVPFGG--PRRNKETMY---KITTEKPPGAIAGVQRQENGSIEWSYE--LPLTCQL----SVGLKDQLVPILANILEVDQEKCWGFD----------------------------Q G_gallus_ENSGALP00000015982 GSLPFRPFEG--PRRNKEVMY---KIITGKPSGAISGIQKAANGPIEWSWE--MPISCSL----SKGLQVLLTPVLANILEADQEKCWGFD----------------------------Q R_norvegicus_ENSRNOP00000030127 GSLPFIPFGG--PRRNKEIMY---RITTEKPAGAISGTQKQENGPLEWSYS--LPITCRL----SVGLQSQLVPILANILEAEQAKCWGFD----------------------------Q X_tropicalis_ENSXETP00000017637 GVPPFLGQKQ-------IVLE---KIKNEE-----------------------PPY--------PSVLSVVAVSLIQGLLKKDPMERLG------------------------------A M_musculus_ENSMUSP00000054126 GSLPFIPFGG--PRRNKEIMY---RITTEKPAGAISGTQKQENGPLEWSYS--LPITCRL----SMGLQNQLVPILANILEVEEDKCWGFD----------------------------Q D_rerio_ENSDARP00000036490 GYPPFNTECT--TM---SVRE---QIINGE-----------------------YRFIPSQ----WKNVSNEAKDLVKKLLVVDPQKRLS------------------------------- O_anatinus_ENSOANP00000008566 GSLPFVPFGG--PRRNKEIMF---RMTSEKPAGAIAGVQKRESGPLEWSYD--LPTTCQL----SGGLRAQLVPILANVLEVDQEKCWGFN----------------------------Q C_elegans_Y60A3A.12 GYPPFSEEYT--DM---TMDE---QVLTGR-----------------------LIFHAQ-----WRRITVETQNMIKWMLTVEPSNRPS------------------------------- C_elegans_T08D2.7 GYPPFSEEYT--DL---KMDE---QVLTGR-----------------------LFFHEQ-----WHRITDETQNMIQWMLTVEPLIRPS------------------------------- R_norvegicus_ENSRNOP00000020214 GQSPFQQRKK--KIKREEVER---LVKEVA-----------------------EEY--------TDRFSPQARSLCSQLLNKDPAERLG------------------------------C O_latipes_ENSORLP00000008832 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRFG------------------------------N B_taurus_ENSBTAP00000010492 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------EVY--------SHKFSEEAKSICKMLLTKDAKQRLG------------------------------C T_rubripes_ENSTRUP00000010568 GEPPYFNQ-T--PI---SAMK---RLRDEA-----------------------PPNDFTL----TLQVSPVLKDFLGCMLTRDTKQRLT------------------------------- R_norvegicus_ENSRNOP00000024227 GYPPFYDESD--P----ELFS---QILRAS-----------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT------------------------------- M_musculus_ENSMUSP00000110117 GYPPFYDESD--P----ELFS---QILRAS-----------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT------------------------------- M_mulatta_ENSMMUP00000008885 GTPPFYAT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISPCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGPDLGTPFTS M_musculus_ENSMUSP00000005164 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRFG------------------------------N T_nigroviridis_ENSTNIP00000012244 GEPPFVSK-T--KS---KLLE---EITEKG-----------------------VTFTQSV----WATVSDAAKKVLTCLLNVDPSYRMS------------------------------- P_pygmaeus_ENSPPYP00000014729 GTPPFYAT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITETAGPDLGTPFTS T_nigroviridis_ENSTNIP00000013350 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRFG------------------------------N H_sapiens_ENSP00000295709 GTPPFYAT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTS R_norvegicus_ENSRNOP00000043572 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRFG------------------------------N P_troglodytes_ENSPTRP00000022091 GTPPFYAT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITESAGPDLGTPFTS P_pygmaeus_ENSPPYP00000003153 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------EVY--------SHKFSEEATSICKMLLTKDAKQRLG------------------------------C M_mulatta_ENSMMUP00000006107 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------EVY--------SRKFSEEAESICKMLLTKDAKQRLG------------------------------C H_sapiens_ENSP00000358104 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------EVY--------SHKFSEEAKSICKMLLTKDAKQRLG------------------------------C P_troglodytes_ENSPTRP00000005279 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------EVY--------SHKFSEEAKSICKMLLTKDAKQRLG------------------------------C O_cuniculus_ENSOCUP00000001738 GTPPFYTT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISPCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIVTEPAGPDLGTPFTS B_taurus_ENSBTAP00000038069 GTPPFYTT-S--IF---QLVS---LILKDP-----------------------VRWP--------PTISPCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTILTEPAGPDFGTPFTS C_familiaris_ENSCAFP00000017912 GQSPFRGRKE--KVKREEVDR---RVLETE-----------------------ETY--------SQKFSEEAKSICKMLLTKDAKQRLG------------------------------C E_caballus_ENSECAP00000008449 GTPPFYTT-S--IF---QLVS---LILKDP-----------------------VRWP--------PTISPCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGHVTIITEPAGSDLGTPFTS B_taurus_ENSBTAP00000053464 GQSPFQQRKK--KIKREEVER---LVKEVP-----------------------EEY--------SEHFSPQARSLCTQLLCKDPSERLG------------------------------C M_musculus_ENSMUSP00000084430 GTPPFYTT-S--IF---QLVS---LILKDP-----------------------VRWP--------STISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSDLGTPFTS R_norvegicus_ENSRNOP00000022839 GTPPFYTT-S--IF---QLVS---LILKDP-----------------------VRWP--------STITSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSNLGTPFTS G_gallus_ENSGALP00000014351 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRYG------------------------------N T_guttata_ENSTGUP00000006845 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRYG------------------------------N C_elegans_ZK909.2c GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VKF--------PSHFSNELKDLLKNLLQVDLTKRYG------------------------------N M_musculus_ENSMUSP00000001115 GQSPFQQRKK--KIKREEVER---LVKEVA-----------------------EEY--------TDRFSSQARSLCSQLLSKDPAERLG------------------------------C B_taurus_ENSBTAP00000001970 GHSPFKKYKE--KVKREEVER---RVNKEA-----------------------EQY--------SEKFSEDARSICSMLLTKDPKQRLG------------------------------C A_carolinensis_ENSACAP00000005713 GYPPFFAD-Q--PI---QIYE---KIVSGK-----------------------VRF--------PSHFSSDLKDLLRNLLQVDLTKRYG------------------------------N A_aegypti_AAEL007931-PA GEPPFFNE-P--PL---QAMR---RIRDMP-----------------------PPKLKNS----H-KVSSRLQNFLDRMLVRDPVQRAT------------------------------- G_aculeatus_ENSGACP00000018211 GEPPYFSD-T--PI---TAMK---KLRDEA-----------------------APTVKNI----H-RMSPVLKDFLSCMLTRDTQQRSS------------------------------- G_aculeatus_ENSGACP00000000485 GSLPFAPFGG--PRKNKPTMY---KITTEKPMGAIAGIQRVEGGQIEWSYH--LPHSCQL----SQGLAMHLVPILAGILEADQERCWGFD----------------------------Q M_domestica_ENSMODP00000006295 GYPPFYDEND--A----KLFE---QILKAE-----------------------YEFDPPY----WDDISDSAKDFIRHLMEKDPEKRFT------------------------------- A_gambiae_AGAP010874-PA GEPPFFNE-P--PL---QAMR---RIRDMP-----------------------PPKLKNS----H-KVSSRLQNFLDRMLVRDPVQRAT------------------------------- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- P_troglodytes_ENSPTRP00000055512 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- M_mulatta_ENSMMUP00000024306 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- C_familiaris_ENSCAFP00000014093 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- B_taurus_ENSBTAP00000009985 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- P_pygmaeus_ENSPPYP00000002975 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- R_norvegicus_ENSRNOP00000034134 CFVLMDNILNLKIVHIL--------NMTSAKIISFLLPYDESLHSLQSRIERETG----------------------------------------------------------------- M_musculus_ENSMUSP00000026217 CFALMDHILNLKIVHIL--------NMTSAKIISFLLPCDESLHSLQSRIERETG----------------------------------------------------------------- E_caballus_ENSECAP00000005937 CFVLMDHILNLKIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- M_domestica_ENSMODP00000013213 CFGQMEQILNLKIAHIL--------NMTSAKIISFLLFPEESLHSLQSRIEHETG----------------------------------------------------------------- G_gallus_ENSGALP00000005196 CFLLMDHILNLKIVHIL--------NMTSAKIVSFLLHPEESLHFLQNRIESETG----------------------------------------------------------------- O_anatinus_ENSOANP00000003934 CFLLMDQILHLKIVHIL--------NMTSAKIISFLLLPDESLHSLQSRIEQETG----------------------------------------------------------------- T_guttata_ENSTGUP00000004836 CFLMMDHILNLKIVHIL--------NMTSAKIVSFLLHPEESLHSLQNRIEFETG----------------------------------------------------------------- A_carolinensis_ENSACAP00000011973 CFQLMDHLLNLKIVHIL--------NMTSAKILSFSLHPEESLHSLQSRIESETG----------------------------------------------------------------- X_tropicalis_ENSXETP00000038296 CFVLMDQILNLKIVHIL--------NMTSAKIHSFHLQ-EESLHTLQSRIETETG----------------------------------------------------------------- T_rubripes_ENSTRUP00000022821 CFEVLEQILSMKVVHIL--------NMTTAQVHSFQLTADENLHSLQKRIEAETK----------------------------------------------------------------- D_rerio_ENSDARP00000013115 CFVLLDQILSMKVVHIL--------NMTTTQVHSFLLSPDEGLHSLQQRIENETK----------------------------------------------------------------- T_nigroviridis_ENSTNIP00000014802 CFEVLEQILSMKVVHIL--------NMTTAQVHSFQLAADENLHSLQKRIEAETK----------------------------------------------------------------- O_latipes_ENSORLP00000016017 CFEVLEQILSMRVVHIL--------NMTTAQVHSFQLSPDESLHSLQKRIEGETK----------------------------------------------------------------- G_aculeatus_ENSGACP00000005520 CFEQLELILSMKVVHIL--------NMTTAQVHSFQLDPEESLHSLQKRIEAETR----------------------------------------------------------------- G_aculeatus_ENSGACP00000008884 CYTALQNILSLKVIHVL--------DMTSAQLHSLILGAEESLHSLQLRLETHTQTH--------------------------------------------------------------- T_rubripes_ENSTRUP00000036336 CNTALQNILNLKVIHVL--------DMTSAQLHSLILGAEENLQSLHLRLEAQTQSH--------------------------------------------------------------- G_gorilla_ENSGGOP00000008804 XXXXXXXXXXXXIVHIL--------NMTSAKIISFLLPPDESLHSLQSRIERETG----------------------------------------------------------------- O_latipes_ENSORLP00000011761 FYSVLHNILSMKVIHVL--------DMTSAQLHSLDLGTDESLLSLQLRLEAQTQAH--------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019642 CNTALQNILNMKVIHVL--------DMTSAQLHSLVLGAEENLQKKRWSL---------------------------------------------------------------------- M_mulatta_ENSMMUP00000010949 CFKALDDILNLKLVHIL--------NMVTGTIHTYPVTEDESLQSLKARIQQDTG----------------------------------------------------------------- H_sapiens_ENSP00000339151 CFKALDDILNLKLVHIL--------NMVTGTIHTYPVTEDESLQSLKARIQQDTG----------------------------------------------------------------- M_musculus_ENSMUSP00000033939 CFRALDDILNLKLVHVL--------NMVTGTVHTYPVTEDESLQSLKTRIQEDTG----------------------------------------------------------------- C_familiaris_ENSCAFP00000008270 CFKALDDILNLKLVHIL--------NMVTGIIHTYPVTEDESLQNLKARIQHDTG----------------------------------------------------------------- A_carolinensis_ENSACAP00000012680 CFKALDDILNLKLVHIL--------NMVTGIVHVYPLAEEETLQSIKAKVEAETG----------------------------------------------------------------- R_norvegicus_ENSRNOP00000025851 CFRALDDILNLKLVHIL--------NMVTGTIHTYPVMEDESLQSLKTRIREDTG----------------------------------------------------------------- G_gallus_ENSGALP00000005924 CFKALDDILNLKLLHVL--------NMVTGTVHTYPVTEEETLQTVKARIQSDTG----------------------------------------------------------------- O_anatinus_ENSOANP00000001111 CFKALDDILNLKLIHVL--------NMVTGTMHTYPVTEEESLQSMKARIQADTK----------------------------------------------------------------- P_troglodytes_ENSPTRP00000034602 CFKALDDILNLKLVHIL--------NMVTGTIHTYPVTEDESLQSLKARIQQDTG----------------------------------------------------------------- O_latipes_ENSORLP00000003067 CFSQLELILKLKLVHIL--------NMMSAKILTYSVADDETVADLQLRIEKDTG----------------------------------------------------------------- B_taurus_ENSBTAP00000049055 CFKALDDILNLKLLHVL--------NMVTGTLHTYPVTEDESLQSLKARIRQDTG----------------------------------------------------------------- M_domestica_ENSMODP00000012792 CFKALDDILNLKLVHIL--------NMVTGTVHTYPIMEKESLQSLKARIQADTG----------------------------------------------------------------- X_tropicalis_ENSXETP00000036619 CFQALDSILSLKLLSVL--------NMVSGKVHTYPVSENENLQNLKSRLEQDTG----------------------------------------------------------------- P_pygmaeus_ENSPPYP00000020804 CFKALDDILNLKLVHIL--------NMVTGTIHTYPVTEDESLQSLKARIQQDTG----------------------------------------------------------------- O_cuniculus_ENSOCUP00000011297 CFILMDHILNLKXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------------------------------------------------------- G_aculeatus_ENSGACP00000005440 CFSQLEVILQLKLVHVL--------NMISAKILTYSVSEEETVADLQLRIEKDSN----------------------------------------------------------------- T_guttata_ENSTGUP00000016868 -------VLFLQIVHIL--------NMTSAKIVSFLLHPEESLHSLQNRIEFETG----------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019003 CFSQLRLILQLKLVHVL--------NMMSAKILSYSVSEDETVADLQLRIEADTN----------------------------------------------------------------- E_caballus_ENSECAP00000003662 LWLGINIWVVLQLVHIL--------NMVTGTIHTYPVTEDESLQSLKARIQQDTG----------------------------------------------------------------- T_rubripes_ENSTRUP00000041917 CFSQLEVILQLKLVHVL--------NMMSAKILSYSVSDDETVADLQLRIEKDTE----------------------------------------------------------------- G_gorilla_ENSGGOP00000006628 CFKALDDILNLKLVHIL--------NMVTGTIHTYPVTEDESLQSLXXXXXXXXX----------------------------------------------------------------- O_cuniculus_ENSOCUP00000006175 CFKALDDILNLKLVHIL--------NMVTGTVHSYPVSEDESLQSLKARIQSDTG----------------------------------------------------------------- T_guttata_ENSTGUP00000005662 CFKALDDILNLKV----------------------------------------------------------------------------------------------------------- A_aegypti_AAEL003245-PA IFSMLDSILSKKILTMF--------CLYDFRFLSIEIDETTDLKTLCSAITSQTG----------------------------------------------------------------- A_gambiae_AGAP009166-PA IFSLLDQILEKRILVLF--------SLHDCRWIDLEVTPDTSMAAVREHVYQLTG----------------------------------------------------------------- A_aegypti_AAEL010548-PA IFSMLDSILSKKILTMF--------CLYDFRFLSIEIDETTDLETLCSAITSQTG----------------------------------------------------------------- D_melanogaster_FBpp0082690 VFADLDKILNMNVLTIF--------AVNNCERLEYAVSAEMTMKDLIALIVLDTG----------------------------------------------------------------- A_aegypti_AAEL005359-PA FFYEVQHILNKKVLHIF--------YTNQATSIEVYMDPEESFFNLKEHVMVQTK----------------------------------------------------------------- A_gambiae_AGAP009565-PA FFLEVQNILNKTVLHIF--------YVNRATSIEVYLEPEQTLVHLLEHILAQTD----------------------------------------------------------------- A_carolinensis_ENSACAP00000012863 FFAEANDILHRTIIHVF--------SLSQAVMLHVYIHPYNTAIKFLEEVFRQTS----------------------------------------------------------------- C_intestinalis_ENSCINP00000011687 YFAEVEDILSKKVINVF--------SVPNAMLHKVYISPEKTLVSFQEAVAELTE----------------------------------------------------------------- D_rerio_ENSDARP00000014302 FFSATNDILNRITIYIF--------SLQQATTYSIYIQFHNTVSIFFEDVQAQTG----------------------------------------------------------------- D_rerio_ENSDARP00000074566 FFSATNDILNRITIYIF--------SLQQATTYSIYIQFHNTVSIFFEDVQAQTG----------------------------------------------------------------- D_melanogaster_FBpp0080920 FFHEVTLILRKRVIHVF--------FTNRTSSVEVFLEPDEQIDNFRERIFLQTE----------------------------------------------------------------- D_rerio_ENSDARP00000087779 FFAETSDILHRIVVYVF--------SLQQATLHHVYIHTYNTANLFQELLFRRTN----------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005945 FFAETNDILHRTVVYVF--------SLQQATLHHVYIQEYNTAVLFQELLSRRTS----------------------------------------------------------------- H_sapiens_ENSP00000356087 FFAETSDILQRVVVHVF--------SLSQAVLHHIYIHAHNTIAIFQEAVHKQTS----------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000308 FFAETSDILQRVVVHVF--------SLSQAVLHHIYIHAHNTIAIFQEAVHKQTS----------------------------------------------------------------- G_aculeatus_ENSGACP00000000783 FFAETNDILHRTVVYVF--------SLQQATLHHIYIHEYNTAALFQELLSRRTS----------------------------------------------------------------- T_rubripes_ENSTRUP00000005087 FFTATTDILKRQPVHLF--------SLQQAMAHCIYIHHYDTVATFFEEVASQTG----------------------------------------------------------------- M_mulatta_ENSMMUP00000038190 FFAETSDILQRVVIHVF--------SLSQSVLHHVYIHAHNTIAIFQEAVHKQTS----------------------------------------------------------------- O_latipes_ENSORLP00000019746 FFTATTDILQRQPVHVF--------SLQQATAHSIYMHHYKTVMVFFEEVASQTG----------------------------------------------------------------- O_cuniculus_ENSOCUP00000010441 FFAETSDILHRMIIHVF--------SLQQMTAHKIYIHSYNTATVFHELVYKQTK----------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005386 FFAETSDILHRMIIHVF--------SLQQMTAHKIYIHSYNTATVFHELVYKQTK----------------------------------------------------------------- M_mulatta_ENSMMUP00000010063 FFAETSDILHRMIIHVF--------SLQQMTAHKIYVHSYNTATIFHELVYKQTK----------------------------------------------------------------- P_troglodytes_ENSPTRP00000008798 FFAETSDILHRMVIHIF--------SLQQMTAHKIYIHSYNTATIFHELVYKQTK----------------------------------------------------------------- E_caballus_ENSECAP00000018587 FFAETSDILHRMIIHVF--------SLQQMTAHKIYIHSYNTAAVFHELVYKQTK----------------------------------------------------------------- B_taurus_ENSBTAP00000046540 FFAETSDILQRGVIHVF--------SLPQAVLHR-YVHAHNTIAIFLEAVYEQTG----------------------------------------------------------------- H_sapiens_ENSP00000329967 FFAETSDILHRMVIHVF--------SLQQMTAHKIYIHSYNTATIFHELVYKQTK----------------------------------------------------------------- C_familiaris_ENSCAFP00000000505 FFAETSDILHRMIIHVF--------SLQQMTAHKIYIHGYNTATVFHELVYKQTK----------------------------------------------------------------- R_norvegicus_ENSRNOP00000009260 FFAETSDVLHRMVIHVF--------SLQHMTALKIYIHSYNTAAVFHELVYKQTK----------------------------------------------------------------- M_musculus_ENSMUSP00000020316 FFAETSDVLHRMVIHVF--------SLQHMTAHKIYIHSYNTAAVFHELVYKQTK----------------------------------------------------------------- A_carolinensis_ENSACAP00000003243 FFAESSDILHRIIIHVF--------SLQQMTLHKIYIHMHNDAVMFHELVYKQTM----------------------------------------------------------------- E_caballus_ENSECAP00000000587 FFAETSDILQRVIVHVF--------SLSEAVLHHVYIHGHNTIAIFLEAVYEQTN----------------------------------------------------------------- T_guttata_ENSTGUP00000006693 FFAETSDILHRIIIHIF--------SLQQMTLHKVYIHNYNTAAIFHELVYKQTK----------------------------------------------------------------- X_tropicalis_ENSXETP00000015947 FFAVTNDVFNRIVIHVF--------SLQQMTPHKIYINTYDKVPDFHDLVYKQTK----------------------------------------------------------------- M_domestica_ENSMODP00000002458 FFAETSDILQRIVVHVF--------SLPQAVLHHVYVHAHNTIGIFLEAVYKQTS----------------------------------------------------------------- B_taurus_ENSBTAP00000023134 FFAETSDILHRMIVHVF--------SLQQMTAHKVYIHGYNTATVFHELVYKQTK----------------------------------------------------------------- G_gallus_ENSGALP00000021757 FLAETNDILHRIVVDVF--------SLQQASSHRIYIHSYNTTSKFLDAVFKQTD----------------------------------------------------------------- G_gallus_ENSGALP00000015982 FFAETSDILHRIIIHIF--------SLQQMTLHKVYIHSYNTAAIFHELVYKQTK----------------------------------------------------------------- R_norvegicus_ENSRNOP00000030127 FFAETSDILQRTVIHVF--------SLPQAVLHHIYIHAHNTIAIFLEAVYEQTN----------------------------------------------------------------- X_tropicalis_ENSXETP00000017637 SDRDAEEVMESSFFKKL--------DFDALSEKKVTPPFIPQNK---------------------------------------------------------------------------- M_musculus_ENSMUSP00000054126 FFAETSDILQRTVIHVF--------SLPQAVLHHVYIHAHNTIAIFLEAVYEQTN----------------------------------------------------------------- D_rerio_ENSDARP00000036490 ----VEEALEHPWLKDD--------RMRQNANQLMNPGAANQPMRPEATRKRKAQ----------------------------------------------------------------- O_anatinus_ENSOANP00000008566 FFAETSDTLHRVVVHVF--------SLPQAVLHHVYVHAHNTTAVFLESVFKQTN----------------------------------------------------------------- C_elegans_Y60A3A.12 ----AVELMSTQWMKCA--------DCRTAKQDILKSIKPISAAAPAALQTTQAGPVKKAKM---------------------------------------------------------- C_elegans_T08D2.7 ----AVELMSTQWMKCA--------DCLSAKQDILKSIQPIS-AAPAALQTTQAGPV--------------------------------------------------------------- R_norvegicus_ENSRNOP00000020214 RGGGAREVKEHPLFKKL--------NFKRLGAGMLEPPFKPDPQAIYCKDVLDIE----------------------------------------------------------------- O_latipes_ENSORLP00000008832 LRNGVNDIKGHKWFATT--------DWIAIYQRKVEAPFIPKCKGPGDTSNFDDY----------------------------------------------------------------- B_taurus_ENSBTAP00000010492 QEEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFVPDPRAVYCKDVLDIE----------------------------------------------------------------- T_rubripes_ENSTRUP00000010568 ----SADLLEHPFLLQA--------DSPGCLMPLVQKHCKRMSLC--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000024227 ----CQQALQHLWISGDAALDR---DILGSVSEQIQKNFARTHWKRAFNATSFLR----------------------------------------------------------------- M_musculus_ENSMUSP00000110117 ----CQQALQHLWISGDAAFDR---DILGSVSEQIQKNFARTHWKRAFNATSFLR----------------------------------------------------------------- M_mulatta_ENSMMUP00000008885 RLPPELQVLKDEQAHRL--------APKGNQSRILTQAYKRMAEEAKQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASEMKSSWVESETGEAPPAPRENWTTPDC M_musculus_ENSMUSP00000005164 LKNGVSDIKTHKWFATT--------DWIAIYQRKVEAPFIPKFRGSGDTSNFDDY----------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012244 ----PSQLLENPWITGDTSVPATPCNVLEMMRQDLEEKDSKTISLFSEEFTEKMS----------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 RLPPELQVLKDKQAHRL--------SPKGNQSRILTQAYERMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAESGTGEAPSAPRENRTTPDC T_nigroviridis_ENSTNIP00000013350 LRNGVNDIKGHKWFATT--------DWIAIYQRKVEAPFIPKCKGPGDTSNFDDY----------------------------------------------------------------- H_sapiens_ENSP00000295709 RLPPELQVLKDEQAHRL--------APKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDC R_norvegicus_ENSRNOP00000043572 LKNGVSDIKTHKWFATT--------DWIAIYQRKVEAPFIPKFRGSGDTSNFDDY----------------------------------------------------------------- P_troglodytes_ENSPTRP00000022091 RLPPELQVLKDEQAHRL--------APKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAESGTGEVPSAPRENRTTPDC P_pygmaeus_ENSPPYP00000003153 QEEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFVPDPRAVYCKDVLDIE----------------------------------------------------------------- M_mulatta_ENSMMUP00000006107 QEEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFVPDPRAVYCKDVLDIE----------------------------------------------------------------- H_sapiens_ENSP00000358104 QEEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFVPDPRAVYCKDVLDIE----------------------------------------------------------------- P_troglodytes_ENSPTRP00000005279 QEEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFVPD------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 RLPPELQVLKDEQAHRL--------APKGSQSRILRQAYKRMAEAAKQKKHQSTGRAPEQEDRTSQAAADTAPLPRPRGTPQEASLLAGILASEMKSSWAEWGPGEAPPAPRENRSTADG B_taurus_ENSBTAP00000038069 RLPPELQVLKDQQAHRL--------APKGNRSHILRQACKRMAEEAKQKKHQNTEPPLEQEDRTSKVAPGTAPLPKLKDTPQEPGLLTGVVASEMKSSWAEWGAGEAPPAPRENWITQDC C_familiaris_ENSCAFP00000017912 REEGAAEVKRHPFFRNM--------NFKRLEAGMLDPPFIPDPRAVYCKDVLDIE----------------------------------------------------------------- E_caballus_ENSECAP00000008449 RLPPELQVLKDQQAHRL--------VPKGNQFRILRQACKRMAEELKQKRHQNTGPALEQEDRTSKVASGTASPPRLRATPQESGLLAGILASEMKSSWAECGAGEDPPAPRENWTTQDC B_taurus_ENSBTAP00000053464 GGGGAQEVKEHPLFKKL--------NFKRLGAGMLEPPFKPDPQAIYCKDVLDIE----------------------------------------------------------------- M_musculus_ENSMUSP00000084430 RLPPELQVLKDEQAHRL--------APKGNQSRILRQACKLMAEEAKQKEDQNAGSALEQEDGLCKVTPSTAPVPGLKATPQESSLLAGILASEMKNNWEDWGAGEAPRTSRENHINLEC R_norvegicus_ENSRNOP00000022839 RLPPELQVLKDEQAHRL--------APKGNQSRILRQACKRMAEEAKQKEDQNTGSTLDQEARLSKVTPSTAPVPGLKATPQESSLLAGLLASEMKNNWEDWGAGEAPPTPRENHITLEC G_gallus_ENSGALP00000014351 LKNGVNDIKNHKWFATT--------DWIAIYQRKVEAPFIPKCRGPGDTSNFDDY----------------------------------------------------------------- T_guttata_ENSTGUP00000006845 LKNGVNDIKNHKWFATT--------DWIAIYQRKVEAPFIPKCRGPGDTSNFDDY----------------------------------------------------------------- C_elegans_ZK909.2c LKNGVADIKNHKWFGST--------DWIAIYQKKVSSYPI-------------------------------------------------------------------------------- M_musculus_ENSMUSP00000001115 RGGGAREVKEHPLFKKL--------NFKRLGAGMLEPPFKPDPQAIYCKDVLDIE----------------------------------------------------------------- B_taurus_ENSBTAP00000001970 RGEGAAEVKGHPVFRDI--------NFRRLEAHMLDPPFHPDPQAVYCKDILDIE----------------------------------------------------------------- A_carolinensis_ENSACAP00000005713 LKNGVNDIKNHKWFATT--------DWIAIYQRKVEAPFIPKCRGPGDTSNFDDY----------------------------------------------------------------- A_aegypti_AAEL007931-PA ----AAELLAHPFLRQA--------GPPSLLVPLMRGARH--SNC--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000018211 ----ATDLLEHPFLLQA--------SSPRCLVPLVEQHRKHMSLC--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000485 FFKATTDVLQRQPVHLF--------SLHQAMAHCVYIHHYNTVLMFLEEVASQTG----------------------------------------------------------------- M_domestica_ENSMODP00000006295 ----CEQALQHPWIAGDTALDK---NIHQSVSEQIKKNFAKSKWKQAFNATAVVR----------------------------------------------------------------- A_gambiae_AGAP010874-PA ----AAELLAHPFLRQA--------GPPSLLVPLMRGARH--SNC--------------------------------------------------------------------------- 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- P_troglodytes_ENSPTRP00000055512 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- M_mulatta_ENSMMUP00000024306 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- C_familiaris_ENSCAFP00000014093 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- B_taurus_ENSBTAP00000009985 -------------------INT--GSQELLSEMGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- P_pygmaeus_ENSPPYP00000002975 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- R_norvegicus_ENSRNOP00000034134 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- M_musculus_ENSMUSP00000026217 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- E_caballus_ENSECAP00000005937 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- M_domestica_ENSMODP00000013213 -------------------INT--ASQELLLEMGISLDPRKPASQCVLDGV-----RGCDS------------YMVYLFD---------------------------------------- G_gallus_ENSGALP00000005196 -------------------IST--GNQELLLETGICLDPRKPASQCVIDGV-----RGWDS------------YMVYLFD---------------------------------------- O_anatinus_ENSOANP00000003934 -------------------IST--GTQELLLEMGISLDPRKPASQCVIDGV-----RGWDS------------YMVYLFD---------------------------------------- T_guttata_ENSTGUP00000004836 -------------------IST--GNQELLLETGICLDPRKPASQCVIDGV-----RGWDS------------YMVYLFD---------------------------------------- A_carolinensis_ENSACAP00000011973 -------------------IST--GNQDLLLEMGICLDPRKPASQCVIDGI-----RGWDS------------YMVYLFD---------------------------------------- X_tropicalis_ENSXETP00000038296 -------------------IST--CNQELLLEMGVSLDPRKPASQCVIDGV-----KGWDS------------YMVYLFD---------------------------------------- T_rubripes_ENSTRUP00000022821 -------------------IDV--ANQELLQETGVSLDPRKPAAQCVLDGVLNE-HRGWDS------------YIVYLFD---------------------------------------- D_rerio_ENSDARP00000013115 -------------------IEL--LNQDLLQETGVMLDPRKPAAQCVLDGV-----RGWDS------------YIVYLFD---------------------------------------- T_nigroviridis_ENSTNIP00000014802 -------------------IEV--ANQELLQETGVSLDPRKPAAQCVLDGV-----RGWDS------------YIVYLFD---------------------------------------- O_latipes_ENSORLP00000016017 -------------------IEV--VNQELLHETGVSLDPRKPAAQCALDGVKKSLKRGWDS------------YVVYLFD---------------------------------------- G_aculeatus_ENSGACP00000005520 -------------------IEV--VNQELLQETGVSLDPRKPAAQCVLDGV-----RGWDS------------YIVYLFD---------------------------------------- G_aculeatus_ENSGACP00000008884 -------------------VSP--LSQELLLETGISLDPRRPPAHCLPEGL-----RGWDS------------SLVFLFD---------------------------------------- T_rubripes_ENSTRUP00000036336 -------------------IPP--LSQELLLETGVSLDPRRPPSQCLPDGL-----QGCDS------------CIVFLFD---------------------------------------- G_gorilla_ENSGGOP00000008804 -------------------INT--GSQELLSETGISLDPRKPASQCVLDGV-----XXXXX------------XXXXXXX---------------------------------------- O_latipes_ENSORLP00000011761 -------------------ISP--QSQELLLETGNSLDPRRPPIQFLPEGL-----RGWDN------------SIVFLFH---------------------------------------- T_nigroviridis_ENSTNIP00000019642 ------------------------LFSPLL-------------------TL-----RGCDS------------STVFLFD---------------------------------------- M_mulatta_ENSMMUP00000010949 -------------------IPE--EDQELLQEAGLALIPDKPATQCISDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- H_sapiens_ENSP00000339151 -------------------IPE--EDQELLQEAGLALIPDKPATQCISDGKLNEG-HTLDM------------DLVFLFD---------------------------------------- M_musculus_ENSMUSP00000033939 -------------------ILE--TDQELLQEAGLVLLPDKPATQCISDSKTNEG-LTLDM------------DLVFLFD---------------------------------------- C_familiaris_ENSCAFP00000008270 -------------------IPE--KDQELLQEAGLALIPDKPAAQCISDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- A_carolinensis_ENSACAP00000012680 -------------------IPE--QDQELLQEGGLALFPEKPDIQYTADIKLNDA-TAADI------------GLLFLFD---------------------------------------- R_norvegicus_ENSRNOP00000025851 -------------------ILE--TDQELLQEAGLVLLPDKPATQCISDSKTNEG-LTLDM------------DLVFLFD---------------------------------------- G_gallus_ENSGALP00000005924 -------------------IPE--QDQELLQEAGLALFTQKHT----ADSKVNDA-VVADT------------DLLFLFD---------------------------------------- O_anatinus_ENSOANP00000001111 -------------------IPE--EDQELLQEAGLALFSDKPDTQGITDGKLNDG-RIWDM------------DLLFLFD---------------------------------------- P_troglodytes_ENSPTRP00000034602 -------------------IPE--EDQELLQEAGLALIPDKPATQCISDGKLNEG-HTLDM------------DLVFLFD---------------------------------------- O_latipes_ENSORLP00000003067 -------------------ITA--ASQELLLEAGLALEPHVPASQCAVDYSEVDG-RRRDL------------PLVFLFD---------------------------------------- B_taurus_ENSBTAP00000049055 -------------------ILE--EDQELLQEAGLALIPDKPAAQCLSDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- M_domestica_ENSMODP00000012792 -------------------IPE--EDQELLQEAGLALFSDKPATQCIVDSKLNDD-RILDM------------DLIFLFD---------------------------------------- X_tropicalis_ENSXETP00000036619 -------------------IPE--EEQELLQASGLALNPAQPLTQFVVDCTVNDG-RQGEG------------DLIFLFD---------------------------------------- P_pygmaeus_ENSPPYP00000020804 -------------------IPE--EDQELLQEAGLALIPDKPATQCVSDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- O_cuniculus_ENSOCUP00000011297 -------------------XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXX-----RGCDS------------YMVYLFD---------------------------------------- G_aculeatus_ENSGACP00000005440 -------------------IPA--TNQELLLEAGLALEPHGLATQCAVDYTEIDG-RRTDS------------PLVFLFD---------------------------------------- T_guttata_ENSTGUP00000016868 -------------------IST--GNQEMLLETGICLDPRKPASQCVIDGV-----RGWDS------------YMVYLFD---------------------------------------- T_nigroviridis_ENSTNIP00000019003 -------------------IPV--AKQELLLEAGLALEPQAPATQCAINYSEIDG-RRTDS------------PLVFLFV---------------------------------------- E_caballus_ENSECAP00000003662 -------------------IPE--EDQELLQEAGLALIPDKPATQCISDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- T_rubripes_ENSTRUP00000041917 -------------------IPV--VDQELLLEAGLALEPQALAMQCAIDYSQIDG-RRTDL------------PLVFLFV---------------------------------------- G_gorilla_ENSGGOP00000006628 -------------------XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXLNEG-RTLDM------------DLVFLFD---------------------------------------- O_cuniculus_ENSOCUP00000006175 -------------------ISE--QDQELLQEAGLALIPDKPATQCISDGKLNEG-RTLDM------------DLVFLFD---------------------------------------- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA -------------------IVR--EAIEFVLPLDQKLDRVTATT------------KPIDL------------YLDGFHD---------------------------------------- A_gambiae_AGAP009166-PA -------------------IPV--DEIEFILPLEQKQPRVGSDT------------RPYDL------------YLPELQS---------------------------------------- A_aegypti_AAEL010548-PA -------------------I---------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0082690 -------------------MDE--KELYFVLPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWT--KRSNPPVMLYIFQ---------------------------------------- A_aegypti_AAEL005359-PA -------------------VPH--VAQLLLLDSERFEQKVGVNSSGMYTSLKNIMRNTNPVMLFN--IENNNVTLPGELE---------------------------------------- A_gambiae_AGAP009565-PA -------------------VPQ--ASQLLLLDNELFATKVDANTSARGYPPTD---PSNPVMLFN--IENYNVILPTEWD---------------------------------------- A_carolinensis_ENSACAP00000012863 -------------------TAP--CHQEYLFEGHSYE--LEPNLQVCHFPKTT---ETCPFILMS--TDPEDPVGLRYRD---------------------------------------- C_intestinalis_ENSCINP00000011687 -------------------VRS--SKQLLLFDGEQFE--MEQFVPVKSYPHTT---PEHPLILFS--SDINDFQAITIPH---------------------------------------- D_rerio_ENSDARP00000014302 -------------------IEP--AAQQYLFQGHPLI--LDPSMKVVNIPHTS---SDKPMILIS--RRLERIIGYPFEE---------------------------------------- D_rerio_ENSDARP00000074566 -------------------IEP--AAQQYLFQGHPLI--LDPSMKVVNIPHTS---SDKPMILIS--RRLERIIGYPFEE---------------------------------------- D_melanogaster_FBpp0080920 -------------------VPL--EKQILLFNNEHLEKKVTPRTIAKAFPATT---TDQPIFLYS--NDDNNVQLPQQLD---------------------------------------- D_rerio_ENSDARP00000087779 -------------------ITP--SHQELLYEGRRLV--LDPNRQAQTFPKTS---RDNPIMLLC--RDPVNTVGLLFED---------------------------------------- T_nigroviridis_ENSTNIP00000005945 -------------------IPP--HNQELLYEGRRLS--LDSNRQAKTFPQTS---RDNPIMLVS--RESVTTVGLIFED---------------------------------------- H_sapiens_ENSP00000356087 -------------------VAP--RHQEYLFEGHLCV--LEPSVSAQHIAHTT---ASSPLTLFS--TA--IPKGLAFRD---------------------------------------- P_pygmaeus_ENSPPYP00000000308 -------------------VAP--RHQEYLFEGHLCV--LEPSVSAQHIAHTT---ASSPLTLFS--TA--IPKGLAFRD---------------------------------------- G_aculeatus_ENSGACP00000000783 -------------------IPL--HNQELLYEGRRLV--LDPNRQAKMFPKSS---RDNPIMLVS--RESVATVGLIFED---------------------------------------- T_rubripes_ENSTRUP00000005087 -------------------IGV--EQQHLLYLGHALP--LEGSMKAVNLPHTS---PTQPLTLLS--YGFEPNPSLPFRE---------------------------------------- M_mulatta_ENSMMUP00000038190 -------------------VAP--RHQEYLFEGHLCV--LEPSISAQHIAHTT---ASSPLTLFS--TA--IPKGLAFRD---------------------------------------- O_latipes_ENSORLP00000019746 -------------------ISI--QQQHLMYLGHDLP--LEGNMKVVNLPCTS---PSQPLILLS--NSAEASTGLFFRE---------------------------------------- O_cuniculus_ENSOCUP00000010441 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHFPKTT---EENPIFVVS--REPLSTIGLIYEK---------------------------------------- P_pygmaeus_ENSPPYP00000005386 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHFPKTT---EENPIFVVS--REPLNTIGLIYEK---------------------------------------- M_mulatta_ENSMMUP00000010063 -------------------ILS--SNQELIYEGRRLV--LEPGRLAQHFPKTT---EENPIFVVS--REPLNTIGLIYEK---------------------------------------- P_troglodytes_ENSPTRP00000008798 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHFPKTT---EENPIFVVS--REPLNTIGLIYEK---------------------------------------- E_caballus_ENSECAP00000018587 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHLPKTT---EDNPIFVVS--QEPLSAVGLIYEK---------------------------------------- B_taurus_ENSBTAP00000046540 -------------------VAP--QHQEYLFEGHLCV--LEPGLSAQHIAHTT---ASSPLTLFS--TASEPPKGLAFRD---------------------------------------- H_sapiens_ENSP00000329967 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHFPKTT---EENPIFVVS--REPLNTIGLIYEK---------------------------------------- C_familiaris_ENSCAFP00000000505 -------------------IIS--SNQELIYEGRRLI--IEPGRLAQHFPKTT---EENPIFVVS--QEPLSTIGLIYEK---------------------------------------- R_norvegicus_ENSRNOP00000009260 -------------------IIS--SNQELIYEGRRLV--LELGRLAQHFPKTT---EENPIFVTS--REQLNSIGLRYEK---------------------------------------- M_musculus_ENSMUSP00000020316 -------------------IVS--SNQELIYEGRRLV--LELGRLAQHFPKTT---EENPIFVTS--REQLNTVGLRYEK---------------------------------------- A_carolinensis_ENSACAP00000003243 -------------------IPA--NNQELIYEGRRLV--IEPSRLAQAFPRTT---EDNPIIVVS--REAMDIIGLLYEE---------------------------------------- E_caballus_ENSECAP00000000587 -------------------VAP--QHQEYLFEGHLCV--LEPNLSAQHIAHTT---ASSPLTLFS--MASETPKGLAFRD---------------------------------------- T_guttata_ENSTGUP00000006693 -------------------IPS--QNQELIYEGRRLI--LEPGRLAQHFPRTT---EENPIFVVS--REAVNIVGLIYEE---------------------------------------- X_tropicalis_ENSXETP00000015947 -------------------IPA--QNQELLFEGRRLV--LEQGRLAQHFPITT---EENPIFVLT--REMVSVIGLRFDE---------------------------------------- M_domestica_ENSMODP00000002458 -------------------VEP--SHQEYLFEGHPCL--LEPSLPAQFLAQTT---EDSPLTLLN--EDSDNPTGLAFRN---------------------------------------- B_taurus_ENSBTAP00000023134 -------------------IIS--SNQELIYEGRRLV--LEPGRLAQHFPKTS---EENPIFVVS--REPLSTIGLIYEK---------------------------------------- G_gallus_ENSGALP00000021757 -------------------IVP--HHQEYFFEGHPYE--LDPNLQAHNFCRTA---RHNPLTLLSCAEQPEDVVGVRYRD---------------------------------------- G_gallus_ENSGALP00000015982 -------------------IPS--QNQELIYEGRRLI--LEPGRLAQHFPRTT---EENPIFVVS--REAVNIVGLVYEE---------------------------------------- R_norvegicus_ENSRNOP00000030127 -------------------VAP--KHQEYFFEGHPCV--LEPSLSAQHIAHTA---ASSPLTLFS--MASDTPKGLAFRD---------------------------------------- X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 -------------------VTP--KHQEYLFEGHPCV--LEPSLSAQHIAHTA---ASSPLTLFS--MSSDTPKGLAFRD---------------------------------------- D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 -------------------IAP--DHQEYLFEGHPCL--LEPSLPAQHLVKTS---ASSPLTLLS--VEPKSPLGLTFRD---------------------------------------- C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 GQAFPEERPEVLGQRGTDAVDLENEEPDSDNEWQHLLETTEPVPVQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLPLS M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 ERAFPEERPEVLGQRSTDAVDLEDEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLS T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 ERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLS R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 ERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLS P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 GQGFAEPRPEAVSPRSISAVKPENEEPDSDEEWQHLLETLEPVPIQLKAPLTLLCNPDFCQHIQTQLHASGAQILKGSLEGASHILPALRVLSSLLSSCSDSAPLYSFCREAGLPGLLLS B_taurus_ENSBTAP00000038069 EQVFPELRPEVKGQQSLDAVDLENEEQDSDDEWQYLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGEQILKGALEGAPCILPALRVLSSLLSSCSDSVPLYSFCREAGLPGLLLS C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 ERAFPELRPEVMGQQSIDAVDLENEEPDSDDEWKHLLETSKPMPIQLKAPLTLLCNPDFCQRIQAQLHEAAGQILKGMLEGASQILPALRVLSSLLSSCSDSVPLYSFCREAGLPGLLLS B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 EQGFPEPRPEAMGRQSTDVVDPENEEPDSDDEWQRLLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLPELPLS R_norvegicus_ENSRNOP00000022839 EQAFPELRPETMGRRSTDAVDPENEEPDSDDEWQRLLETMEPVPVQLKSPLTLLCNPDFCQHIQSQLRGTGEQILKGVLDGASHLLPALRILSSLLSSCSDSVLLYSFCQEVGLPELPLS G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 -------------------IAV--QLQHLLYLGHKLP--LEGNMKVANLPHTS---HDRPLILLS---GPDTNGSFPFRE---------------------------------------- M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 LLRHSQESNSLQQQSWYGTFLRDLMAVIQAYFACTFNLERSQTGDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGL M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 LLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTKQVVLDGLLHGL T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 LLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGL R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 LLRHSQESNSLQQQSWYGTFLRDLMAVIQAYFACTFNLERSQTNDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGL P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 LLRHSQESSSIQTQPWYGAFVRDLMAAMQAYFACTFNLDRSQTGDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCFTVLCEAMDGNSQAISKAFYSSLLTTQRVVLDGLLHGL B_taurus_ENSBTAP00000038069 LLKHSQESNSIQQQCWYGAFVQDLVAVIQAYFACTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQPDDSEQALRRDILMCFTVLCEAMDGNSWTVSKAFYSSLLTTHRAVLDGLLYGL C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 LLRHSQENNSIQQQCWCGTFLQDLMAVIQAYFACTFNLERSQTGDSLQVFQEAANHFLDLLGKLLAQPDDSEQNLWRDSLMCFIVLCEAMDGNSWTVAKAFYCSLLTTQRAVLDGLLHGL B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 LLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGL R_norvegicus_ENSRNOP00000022839 LLRYSQESSSIQQQPWYGAFLRELVAVVQAYFSCTFNLERSQTGDSLQVFEEAASLFLDLLGKLLAQPDDSEPTFRRDSLMCFAVLCEAVDGNSRAISKAFYASLLTTQRAVLDGLLHGL G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- P_troglodytes_ENSPTRP00000055512 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- M_mulatta_ENSMMUP00000024306 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIVQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- C_familiaris_ENSCAFP00000014093 --KSKTVYEGPFASRS----------LSDCVNYIVRD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- B_taurus_ENSBTAP00000009985 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- P_pygmaeus_ENSPPYP00000002975 --KSKTVYEGPFASRS----------LSDCVNYIVQD----RQNTSFQLYRLRKV-------------------------------WAEAVHYVSGTKKNYSRLFQGQKGLGLSL--L-- R_norvegicus_ENSRNOP00000034134 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPVTQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- M_musculus_ENSMUSP00000026217 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- E_caballus_ENSECAP00000005937 --KSKTVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPIIQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- M_domestica_ENSMODP00000013213 --KSKIVYEGPFASRS----------LSECVNYIVKD----SK-IQLPVMQLRRV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- G_gallus_ENSGALP00000005196 --KSKTVYDGPFASRS----------LSECVNYIVQD----SK-IQLPIPQLRKV-------------------------------WAEAVHYVIGLKEDYSRLFQGQRAAMLSL--L-- O_anatinus_ENSOANP00000003934 --KSKIVYEGPFASRS----------LSDCVNYIVQD----SK-IQLPITQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- T_guttata_ENSTGUP00000004836 --KSKTVYDGPFASRS----------LSDCVNYIVQD----SK-IQLPIPQLRKV-------------------------------WAEAVHYVIGLKEDYSRLFQGQRAAMLSL--L-- A_carolinensis_ENSACAP00000011973 --KSKTIYEGPFASRS----------LSDCVNYIVQD----SK-IQLPILQLRKI-------------------------------WAEAVYYVIGLKEDYSRLFQGQRAAMLSL--L-- X_tropicalis_ENSXETP00000038296 --KSKTVYEGPFQSRS----------LSECLNYIVQD----SK-VQLPIPQLRKV-------------------------------WAEAVHYVSGLKEDYSRLFQGQRAAMLSL--L-- T_rubripes_ENSTRUP00000022821 --KSITTYSGPFSARQ----------LSDKVHTIVQD----AK-KQLPLVVLKKI-------------------------------WGEAVSYICGLKEDYSRLFQGQRAAMLSL--L-- D_rerio_ENSDARP00000013115 --KSLTKYMGPLTART----------LPESVNFIVRE----TK-TQLPLSTLKKV-------------------------------WGEAVSYICGLREDYSRLFQGQRAAMLSL--L-- T_nigroviridis_ENSTNIP00000014802 --KSITTYSGPFSARQ----------LSDKVHTIVQE----AK-KQLPLEVLKKI-------------------------------WGEAVSYICGLKEDYSRLFQGQRAAMLSL--L-- O_latipes_ENSORLP00000016017 --KSLTKYSGPFSARR----------LPEKVNTIVQE----PK-TQLPLVVLKKV-------------------------------WGEAVSYICGLKEDYCRLFQGQRAAMLSL--L-- G_aculeatus_ENSGACP00000005520 --KSINKYSGPLSARK----------LPDKVNMIVQE----AK-TELPLVALKMV-------------------------------WGEAVSYICGLKDDYSRLFQGQRAAMVSL--P-- G_aculeatus_ENSGACP00000008884 --KSLTKYSGPLTARP----------LPDSVNFIVRE----TK-TQLPLSALRKV-------------------------------WGEAVSYICGLKEDYIRLYQGQRAAMLSL--L-- T_rubripes_ENSTRUP00000036336 --KSLNKYSGPLTARP----------LPDSVNFIVRE----TK-TQLPLTALRKV-------------------------------WGEAVSYICGLKEDYIRLYRGQRAAILSL--L-- G_gorilla_ENSGGOP00000008804 --XXXXXXXXXXXXXX----------XXXXXXXXXXX----XX-XXXXXXXXXXX-------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX--X-- O_latipes_ENSORLP00000011761 --TSLNKYSGPLTARP----------LPESVNFIVRE----TK-TQLPLSTLRKV-------------------------------WAEAVSYVCGLKEDYFRLYQGQRTAMLSL--L-- T_nigroviridis_ENSTNIP00000019642 --KSLNKYSGPLTARP----------LPDSVNFIVRE----TK-TQLPLTALRKV-------------------------------WGEAVSYICGLKEDYIRLYSGQRAAILSL--L-- M_mulatta_ENSMMUP00000010949 --NSKITYETQISPRP----------QPESVSCILQE----PK-RNLAFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- H_sapiens_ENSP00000339151 --NSKITYETQISPRP----------QPESVSCILQE----PK-RNLAFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- M_musculus_ENSMUSP00000033939 --NSKINYETQITPRP----------QPESVSCILQE----PK-RNLSFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMSL--L-- C_familiaris_ENSCAFP00000008270 --NSKIAYETQISPRP----------QPESVSCILQE----PK-RNLSFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- A_carolinensis_ENSACAP00000012680 --NRKVTYESQISPRP----------HPDSINCILQD----PK-KTLAFFQLRKV-------------------------------WGQVWHSIRRLNEDFNQLQNGQRAAMRNL--L-- R_norvegicus_ENSRNOP00000025851 --NSKMSYETQITPRP----------QPESVSCVLQE----PK-RNLSFFQMRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- G_gallus_ENSGALP00000005924 --NQKVAYEAQVALRP----------HPESVDYILQD----PK-KNLHFFQLRKV-------------------------------WGQIWHTIRMLKEDCNRLQQGQRAAMMNL--L-- O_anatinus_ENSOANP00000001111 --NSKVTYETQISPRS----------HPESVSCILQE----PK-KNLAFFQLRKV-------------------------------WGQVWHTIRTLKEDCNRLQQGQRAAMMNL--L-- P_troglodytes_ENSPTRP00000034602 --NSKITYETQISPRP----------QPESVSCILQE----PK-RNLAFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- O_latipes_ENSORLP00000003067 --RSSCTYQPQFAPRT----------LPENIRFVQMD----PK-HVLPYSPLRRT-------------------------------CGQAWHTIRSLKEDWQRLQQGQKAAIMSL--L-- B_taurus_ENSBTAP00000049055 --NSRVTYESQVSPQP----------QPESVSCILQE----PK-RNLPFFQLRKV-------------------------------WGQVWHSIQALKEDCSRLQQGQRAAMMNL--L-- M_domestica_ENSMODP00000012792 --NRKITYETQISPRP----------PPESVSCILQE----PK-RNLPFFQLRKV-------------------------------WGQVWHTIRTLKEDCSQLQQGQRAAMMNL--L-- X_tropicalis_ENSXETP00000036619 --NRKTVYEPQISLPA----------HPESVTVILQD----PK-RPLTYTHLRRV-------------------------------WGQTWQTIRAMKEDCARLLHGQRTFMVNL--L-- P_pygmaeus_ENSPPYP00000020804 --NSKITYETQISPRP----------QPESVSCILQE----PK-RNLAFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- O_cuniculus_ENSOCUP00000011297 --KSKTVYEGPFASRS----------LSDCVNYISED------------------------------------------------------HYVWGLKEDYRKLFLGLRAAMLSL--L-- G_aculeatus_ENSGACP00000005440 --RSSCSYEPQFAPRT----------LPENIRFIQTC----HK-PILAYSPLRRT-------------------------------CGQAWHTIRSLKDDWQRLQQGQKAAIMSL--L-- T_guttata_ENSTGUP00000016868 --KSKTVYDGPFASRS----------LSDCVNYIVQD----SK-IQLPIPQLRKV-------------------------------WAEAVHYVIGLKEDYSRLFQGQRAAMLSL--L-- T_nigroviridis_ENSTNIP00000019003 --RPPCSYEPQFAPRV----------LPENIRFVQSD----PK-HVLAYSPLRRT-------------------------------CGQAWHTIRSLKEDWQRLQQGQKAAIMSL--L-- E_caballus_ENSECAP00000003662 --NSKIAYETQISPRP----------QPESVSCILQE----PK-RSLSFFQLRKV-------------------------------WGQVWHSIQTLKEDCSRLQQGQRAAMMNL--L-- T_rubripes_ENSTRUP00000041917 --RSTCSYEPQFAPRT----------LPENISYVQSD----PK-IVLAYRPLRRT-------------------------------CGQAWHTIRSLKEDWQRLQQGQKAAIMSL--L-- G_gorilla_ENSGGOP00000006628 --NSKITYETQISPRP----------QPESVSCIXXX----XX-XXXXXXXXXXX-------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXMNL--L-- O_cuniculus_ENSOCUP00000006175 --NSKVAYETQISPRP----------QPESVSCILQE----PK-RNLPFFQLRKV-------------------------------WGQVWHSIQTLKEDCNRLQQGQRAAMMNL--L-- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ---KPMLFIIKQG---AIIQADLKPQIPKSVTDVFQN----IK-VKLKPHMLRQF-------------------------------VSNAWYFVTNEQRIYGTALDGIKNYGLML----- A_gambiae_AGAP009166-PA --GKPMVYVAHRASRESIVQRDLKPRIPKSITDVFQN----IK-VKLKPHMLRQF-------------------------------IANAYYFIANEQRLYVLLLDGVRNYGLTL----- A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 -VKKECDYK-----------------IPEPILSILSRKFIANKFKTKERWLQKRV-------------------------------VLDMLYVLTKEQARYEMLVSGINERALSL--EDE A_aegypti_AAEL005359-PA -LP----KFPSFPSGVS---------------------------VENDASLAQ-A-------------------------------CSVGHECKRRVENFSMLDTLMNKAVEQFA--GLL A_gambiae_AGAP009565-PA -LP----KFPTFPNGIS---------------------------VENDASLAKVA-------------------------------CSVGHECKRRVESLSLLDTLMNKSVHQFS--GFL A_carolinensis_ENSACAP00000012863 --P--TLEFPRFLPKVD---------------------------VIADCSTAKGV-------------------------------LSATHQTLRISQSFLKDQELILRGLYWLR--YVL C_intestinalis_ENSCINP00000011687 --T---CKPPKVKPSLS---------------------------LDNDSSLAKVC-------------------------------SSTLFDIRKSVSYLLLVQILIRLSVKWFV--CYL D_rerio_ENSDARP00000014302 --P----ESPPMPGKFD---------------------------VVADFVFTKTI-------------------------------VKVIHQYLRIAYSLQEYRQFILQGFNSYI--EQT D_rerio_ENSDARP00000074566 --P----ESPPMPGKFD---------------------------VVADFVFTKTI-------------------------------VKVIHQYLRIAYSLQEYRQFILQGFNSYI--EQT D_melanogaster_FBpp0080920 -LP----KFPVFPPNVS---------------------------VENDASLAKSA-------------------------------CSVGHECKRRVDIFTSMDILIKKGVEHFI--EML D_rerio_ENSDARP00000087779 --P----SPPKVQPRYD---------------------------LDLDASYAKTF-------------------------------AGDVGYLWKTSDSLLLYQELVRKGVRGLN--ELI T_nigroviridis_ENSTNIP00000005945 --P----SPPKVQPRYD---------------------------LDLDASYAKTF-------------------------------AGDVGHLWKTSESLLVYQKLVRKGVRGLI--ELI H_sapiens_ENSP00000356087 --P--ALDVPKFVPKVD---------------------------LQADYNTAKGV-------------------------------LGAGYQALRLARALLDGQELMFRGLHWVM--EVL P_pygmaeus_ENSPPYP00000000308 --P--ALDIPKFVPKVD---------------------------LQADYNTAKGV-------------------------------LGAGYQALRLARALLDGQELMLRGLHWVM--EVL G_aculeatus_ENSGACP00000000783 --P----SPPKVQPRYD---------------------------LDLDASYAKTF-------------------------------AGDVGHLWKTSESLLVYQELVRKGVRGLI--ELM T_rubripes_ENSTRUP00000005087 --P----ETPVIPPKFD---------------------------VLADYNFTKVI-------------------------------VGAVHQYLMVTQLLRTHRELLLQGFYSYM--MKL M_mulatta_ENSMMUP00000038190 --P--ALDVPKFVPKVD---------------------------LQADYNTAKGV-------------------------------LGAGYQALRLSRVLLDGQELMLRGLHWVM--EVL O_latipes_ENSORLP00000019746 --P----ESPIIPSKFD---------------------------VLADYNFSRII-------------------------------VGVVHQYLRIVHLLHTHRQLLLQGYYTYM--MKL O_cuniculus_ENSOCUP00000010441 --IHISVSLPKVHPRYD---------------------------LDGDASMAKTI-------------------------------TGVVCYACRIAGTLLLYQELMRKGIRWLX--XXX P_pygmaeus_ENSPPYP00000005386 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACRIASTLLLYQELMRKGIRWLI--ELI M_mulatta_ENSMMUP00000010063 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACRIASTLLLYQELMRKGIRWLI--ELI P_troglodytes_ENSPTRP00000008798 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACRIASTLLLYQELMRKGIRWLI--ELI E_caballus_ENSECAP00000018587 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACRVTSTLLLYQELMRKGIRWLI--ELV B_taurus_ENSBTAP00000046540 --P--ALDVPKFVPKVD---------------------------LQADYSTAKGI-------------------------------LGAGYQACGWHR-LCCGAGADGSGLHWFV--EML H_sapiens_ENSP00000329967 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACRIASTLLLYQELMRKGIRWLI--ELI C_familiaris_ENSCAFP00000000505 --I----SLPKVHPRYD---------------------------LDGDASMAKAI-------------------------------TGVVCYACKIASTLQLYQELMRKGIRWLI--ELV R_norvegicus_ENSRNOP00000009260 --I----SLPKIHPRYD---------------------------LDGDASMAKAV-------------------------------TGVVCYACRTAGTLLLYQELMRKGVRWLI--ELV M_musculus_ENSMUSP00000020316 --I----SLPKIHPRYD---------------------------LDGDASMAKAV-------------------------------TGVVCYACRTASTLLLYQELMRKGVRWLV--ELV A_carolinensis_ENSACAP00000003243 --I----LLPKVHQRYD---------------------------LDSDASMAKTV-------------------------------TGVVCYACRVARALLLYQELMRKGIRWLI--EII E_caballus_ENSECAP00000000587 --P--ALDIPKFVPKVD---------------------------LQADYNTAKGV-------------------------------LGAGYQALRLAQALLAGQELMLRGLHWFV--EIL T_guttata_ENSTGUP00000006693 --V----LLPKVHQRYD---------------------------LDGDASMAKAV-------------------------------TGIVCYACRVASSLLLYQELMRKGIRWLI--EII X_tropicalis_ENSXETP00000015947 --I----VIPKLHSHYD---------------------------LDVDANMAKAV-------------------------------TGVACYYCRIAASLLLVLELMRKGIRWLS--EIL M_domestica_ENSMODP00000002458 --P--SLDVPKFVPKVD---------------------------LQADYNTAKGV-------------------------------LSMGHQVLRISRALQDGQEMMLRGLHWVV--EVL B_taurus_ENSBTAP00000023134 --I----SLPKVHPRYD---------------------------LDGDASMAKAM-------------------------------TGVVCYACRIASTLLLYQELVRKGIRWLI--ELV G_gallus_ENSGALP00000021757 --P--ALDFPKFVPKVD---------------------------VVADCSAAKSA-------------------------------VGAVHQALRIAQELRQCQELTVRGLHWVMIYTAL G_gallus_ENSGALP00000015982 --V----LLPKVHQRYD---------------------------LDGDASMAKEV-------------------------------TRIVCYACRVANSLLLYQELMRRGIRWLI--EII R_norvegicus_ENSRNOP00000030127 --P--ALDVPKFVPKVD---------------------------LQADYSTAKGV-------------------------------LGAGYQALWLARVLLDGQALMLRGLHWVL--VVL X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 --P--ALDVPKFVPKVD---------------------------LQADYSTAKGV-------------------------------LGAGYQALWLARVLLDGQALMLRGLHWVL--EVL D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 --P--ALDIPKFVPKVD---------------------------LLADYNTAKGG-------------------------------LGPGGGSLIWGGGGTRRWELMLRGLTWLV--EML C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 TVPQLPVHTPPGAPQVSQPLREQSEDLPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLALESL--FVL M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 --------------------------------------------------VVEGVT---------------------------------------------------------------- P_pygmaeus_ENSPPYP00000014729 TVPQLPVHTPPGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDGKEQVCWHLANQLTEDSSQLRPSLVSGLQHPILCLHLLKVLYSCCLVSERLCRLLGQEPLALESL--FML T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 TVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESL--FML R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 TVPQLPVHTPPGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESL--FML P_pygmaeus_ENSPPYP00000003153 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- M_mulatta_ENSMMUP00000006107 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- H_sapiens_ENSP00000358104 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 TMPQLPFHTPPGAPQASQPLRDLSEDLPGAVSSALAAVCTAPVGLPSCWEAKEQVSWHLATQLIEDSSQLRPSLVSGLQHPILCLSLLKVLYSCCHVSERLCRLLGQEPLALESL--SLV B_taurus_ENSBTAP00000038069 TAPQLPFHSPPGAPQVSQPLREQSEDLPGAISSVLAAMCTAPVGLPGCWEAKEQIAQHLADQLTKDSNHLRSSLISALQHPILCLPLLKVLYSCCHVSERLCHLLGQEPLALESL--LNL C_familiaris_ENSCAFP00000017912 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- E_caballus_ENSECAP00000008449 TVLQLPVHSPPGAPQVSQPLREQSADLPGALSSALAAICTTPVGLPGCWKAKEQITRHLANQLIEDSTQLRPSIISGLKHPILCLHLLKILYSCCHISEHLCHLLVQEPLALESL--LML B_taurus_ENSBTAP00000053464 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- M_musculus_ENSMUSP00000084430 TVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLALESL--LML R_norvegicus_ENSRNOP00000022839 TVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHILCLHLLKVLYSCCYISERLCHILGQEPLALESL--LML G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 -----------------------------------------------QFSTVKGV----------------------------------------------------------------- B_taurus_ENSBTAP00000001970 -----------------------------------------------QFSTVRGI----------------------------------------------------------------- A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 --P----DTPVIPSRFD---------------------------VIADYNFSKVI-------------------------------VGVVHQYLRLVQSLHTHSGLLLQGYYSYM--MMF M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHAEIMELQKSPYGR--- P_troglodytes_ENSPTRP00000055512 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHAEIMELQKSPYGR--- M_mulatta_ENSMMUP00000024306 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHAEIMELQKSPYGR--- C_familiaris_ENSCAFP00000014093 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHTEIMELQKSPYGR--- B_taurus_ENSBTAP00000009985 -----------RYNTNLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHTEIMELQKSPYGR--- P_pygmaeus_ENSPPYP00000002975 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGICQKKMLKAWKEMEEKAIH-YAE---VGVIGYLEDQIMSLHAEIMELQKEPLWK--- R_norvegicus_ENSRNOP00000034134 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YSE---VGVIGYLEDQIMSLHTEIMELQKSPYGR--- M_musculus_ENSMUSP00000026217 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YSE---VGVIGYLEDQIMSLHTEIMELQKSPYGR--- E_caballus_ENSECAP00000005937 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIH-YAE---VGVIGNLEEQIMSLHTEIMELQKSPYGR--- M_domestica_ENSMODP00000013213 -----------RYNANLTKMKNTMISASQ-------QLKAKLQFFHQSIQLDLDRYSDQMTYGISSEKMLKAWKEMEEKAIQ-CAQ---AGDIGYLDEQIMSLHTEIVELQRSPSAR--- G_gallus_ENSGALP00000005196 -----------RYNANLIKMKNNMVSASQ-------QLKAKLEFFHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKASH-CAQ---AEDIGYLDEQIMALHTEIVELQKSPYAR--- O_anatinus_ENSOANP00000003934 -----------RYNANLTKMKNTMISASQ-------QLKAKLQFFHQSIQLDLDKYSDQMAYGISSEKMLKAWKEMEEKAIH-CAQ---AGDIGYLDEQIMTLHTEIVELQRSPYAR--- T_guttata_ENSTGUP00000004836 -----------RYNANLIKMKNNMVSASQ-------QLKAKLEFFHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKASQ-CAQ---AEDIGYLDEQIMALHTEIVELQKSPYAR--- A_carolinensis_ENSACAP00000011973 -----------RYNANLTKMKNNMVSASQ-------QLRAKLKFFQQSIHLDLERYSDQMTYGISSEKMLKAWKEMEEKALL-CEQ---AGDIGYLDEQIMALHTEIVELQRSPHAR--- X_tropicalis_ENSXETP00000038296 -----------RFNTNLTKMKNTMVSASQ-------QLGAKLQFFKRSIEIDLERYSDQMAYGISSEKMLRAWKEMEDKAVC-FGK---AGKIHFLDETIMGLHTEIVELQKSPCAR--- T_rubripes_ENSTRUP00000022821 -----------RYNTNLTRCKNNMFGFSQ-------QLKAKLDFFKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERAAA-FAQ---VAEVNHLDDEILALHSEIVELQRSPYAR--- D_rerio_ENSDARP00000013115 -----------RFNTNLTRYKNMMFSFSQ-------QLKAKLDFFKTSIQYDLEKYSDQMQYGISSEKMLKAWHENEERAAA-FAQ---VAEIGHLDEEIMALHSEIVELQRSPYAR--- T_nigroviridis_ENSTNIP00000014802 -----------RYNTNLTRCKNNMFGFSQ-------QLKAKLDFFKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERAAA-FAQ---VAEVNHLDDEILALHSEIVELQRSPYAR--- O_latipes_ENSORLP00000016017 -----------RYNTNLTRCKNSMFGFSQ-------QLKAKLDFFKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERAAA-FAQ---VAEVSHLDDEIMALHSEIVELQRSPYAR--- G_aculeatus_ENSGACP00000005520 -----------RYNTNLNRCKNSMFGFSQ-------QLKAKLDFFKSSLPYDLEKYSDQMHYGISSEKMLKAWQENEERAAA-FAQ---VAEVSHLDDEIMALHSEIVELQRSPYAR--- G_aculeatus_ENSGACP00000008884 -----------RYNTNLTRYKNLLFSQSQ-------QLRAKLAIFKTSIQNDLEQYTRQRHVGISSEKMLRTWQENEEKADG-FSK---VAEVGYLDEEIVALHSEIVELQRSPFAR--- T_rubripes_ENSTRUP00000036336 -----------RYNTNLTRYKNLLFSHSQ-------QLQAKLAFFKTSIQQDLEQYSKQRQTGISSEKLLKTWQENQEKADE-FMKVGLVADVAHLDEEIVAVHFEIVELQRSPFAR--- G_gorilla_ENSGGOP00000008804 -----------XXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXGR--- O_latipes_ENSORLP00000011761 -----------RYNTTLTKYKNELFSESH-------KLQAKLAFFKTSIQYDLEQYANQMKNGISSEKMWKTWQESREKVDL-LTKK--AADVGFLDKEILGLHNEIVELQRSPYAR--- T_nigroviridis_ENSTNIP00000019642 -----------RYNTNLTRYKNLLFSCSQ-------QLRAKLAFFKTSIQQDLEQYSKQSQSGISSEKLLRTWQENQEKVDE-FMK---VADVVHLDEEIVAVHFEIVELQRSPFAR--- M_mulatta_ENSMMUP00000010949 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKLLVERMMALQTDIVDLQRSPMGR--- H_sapiens_ENSP00000339151 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKLLVERMMALQTDIVDLQRSPMGR--- M_musculus_ENSMUSP00000033939 -----------RNNSCLSKMKNAMASTAQ-------QLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQ-CGR---ENDVKHLVERMMALQTDIVDLQRSPMGR--- C_familiaris_ENSCAFP00000008270 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKHLVERMMALQTDIVDLQRSPMGR--- A_carolinensis_ENSACAP00000012680 -----------RHNSTLSKMKNNMASLSQ-------QLKAKLDFFKASIQIDLEKYNEQIQFGITSEKLLLAWKEMEQAIEL-RGR---EEDVDQLVKKTMALQTDIVDLQRIPQGR--- R_norvegicus_ENSRNOP00000025851 -----------RNNSCLSKMKNAMASTAQ-------QLKAKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVEQ-CGR---ENDVKVLVERMMALQTDIVDLQRSPMGR--- G_gallus_ENSGALP00000005924 -----------RYNSTLSKMKNSMASLSQ-------QLKAKLDFFKTSIQIDLEKYKEQIEFGITSEKLLFAWKEMEQAVEL-CGR---EDDVDQLVKRMMALQTDIVDLQRSPLGR--- O_anatinus_ENSOANP00000001111 -----------RYNSSLSKMKNSMASMSQ-------QLKAKLDFFKTSVQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---EAEVEQLVGRMMALQTDIVDLQRSPMGR--- P_troglodytes_ENSPTRP00000034602 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKLLVERMMALQTDIV------------ O_latipes_ENSORLP00000003067 -----------RHNSSLSKQKNEMVSMHQ-------RLTAKLEFFTTSLHIDMDKYQEQTATGIASEKLMSVWREMEQTAVSQCGH---QAKVSELEDEMMQLQPDIVDVQRQPW----- B_taurus_ENSBTAP00000049055 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKHLVERMMALQTDIVDLQRSPMGR--- M_domestica_ENSMODP00000012792 -----------RNNSSLSKMKNLMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ESDVKLLVEQMMALQTDIVDLQRSPMSR--- X_tropicalis_ENSXETP00000036619 -----------RYNTELSKKKNLMTSEFE-------QLKAKLDFFRNSIQIDLEKYSEQMEFGITSEKLLSAWRETEQTVEL-CGR---EREVQALVDKMMALQTDSVDLQRNPLGR--- P_pygmaeus_ENSPPYP00000020804 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKLLVERMMALQTDIVDLQRSPMGR--- O_cuniculus_ENSOCUP00000011297 -----------RYNANLTKMKNTLISASQ-------QLKAKLEFFHKSIQLDLERYSEQMTYGIXXXXXXXXXXXXXXXXXX-XXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXX--- G_aculeatus_ENSGACP00000005440 -----------RYNSSLSKQKNEMVSMHQ-------RLMAKLDFFTTSLHIDVDKYQEQTATGIASEKLMGVWREMEQTAVS-CG----QAKVSELEEEMMQLQPDIVDVQRQPW----- T_guttata_ENSTGUP00000016868 -----------RYNANVIKMKNNMVSASQ-------QLKAKLEFFHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKASQ-CAQ---AEDIGYLDEQIMALHTEIVELQKSPYAR--- T_nigroviridis_ENSTNIP00000019003 -----------RHNSSLSKQKNDMVSMYQ-------RLMAKLDFFTTSLHIDMDKYQEQTSTGIVSEKFLGTWRSMEQTAVS-CS----QAKVKELDEEMMQLQPEIVDVQRQPW----- E_caballus_ENSECAP00000003662 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVRHLVERMMALQTDIVDLQRSPMGR--- T_rubripes_ENSTRUP00000041917 -----------RHNSSLSKQKNDMVSMYQ-------RLMAKLDFFTTSLHIDMDKYQEQTSTGIVYEKFLGMWRSMEQTAVT-CS----QARVSELEEEMMQLQPDIVDVQRQPW----- G_gorilla_ENSGGOP00000006628 -----------RNNSCLSKMKNSMASMSQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---ENEVKLLVERMMALQTDIVDLQRSPMGR--- O_cuniculus_ENSOCUP00000006175 -----------RNNSCLSKMKNSMASISQ-------QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVEL-CGR---EDEVKHLVERMMALQTDIVDLQRSPMGR--- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA -------------NDQIVKGRDDVSKLNK----VSYGISGGLEYHKLSLIQAKEMAKVNQ---LPPGTIQQCFSVLEERCTRMEAT---IGKLAEVADKITTRYESVLKRSREAVAHQLL A_gambiae_AGAP009166-PA -------------NDAIARRKEEIGRMNK----VVYGIVGGVEYHKLTVSHTRDALNAGKR--IPSASFETASHQWEEKCSRVETN---VRKLAEMADKISKRYESVLKRSRDALRHALL A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 MMENSFIDSIDKQRIIISFAYDQLTSLLK-------EAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEAC------------LREAKDMVKTTNQLRKEVCEKDLFDCAR--- A_aegypti_AAEL005359-PA KNQLAK----------LCERVKHQEDIGS----STREISDLVQIA------VMN--SYQD-----KASTIHTEMN-SLKAAF-QLVSDPVQQLHNRFVMEESLSREWITAYRELRSPNKN A_gambiae_AGAP009565-PA AGFLVK----------LLKRTRHLEDIEG----LISELTKMFEVA------ASNHETYQK-----LGATILASYE-TQKSDF-QRVSEPIQQLYARFVKEESLVREWNSGYRALRTPNKN A_carolinensis_ENSACAP00000012863 QVCNKI----------SL--IPVSFTFPD----SLFTTS-FVSAF------EKWLTVYSIN----GLLWTLSVLA-QISEEI-SRCSHSISEQQAALQ---GILSEVGKKQNQMKED--- C_intestinalis_ENSCINP00000011687 KSRVVKLKLLRSNLQCKVDCLRTALEIFE----EHYQRETSLLTV-ITNLVTSPPEVNELKLYFTQITEKAKILR-QIRTEF-DQLNESTNQFDKLIIQE-EIPSSIFVDEGSQTND--- D_rerio_ENSDARP00000014302 SSEVID----------VTHRISKVKMKLH----SSISTEKTLHVF-------TQTFAHEFP----DFIDSKKKFP-LIEAELQQMCGRGIREFQNILQ---YLRVTLSKHSETLAND--- D_rerio_ENSDARP00000074566 SSEVID----------VTHRISKVKMKLH----SSISTEKTLHVF-------TQTFAHEFP----DFIDSKKKFP-LIEAELQQMCGRGIREFQNILQ---YLRVTLSKHSETLAND--- D_melanogaster_FBpp0080920 VTTITL----------LLKKTESFDNLLS----TVIDYADVVHSM------ARVTKGDQ------EIKTLLTALE-NVKSDF-DGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKT D_rerio_ENSDARP00000087779 RDEYSE----------TMHKKTEVFHLCS----HCSQTLERSHPA-IHPYVQSFICSSVHP----SIHPSFHLF------------------ICSFIHPSIHLFIHSSVHSSIHSF---- T_nigroviridis_ENSTNIP00000005945 KEDYSE----------ILQKKSEVFHLCN----YCTQILERTEQLWLEVLMQANTMSSEYD----EISDMHKKIV-RISSSL-EPLERTSQDIKTKFLPGGLLTDSWTQQVGTHPED--- H_sapiens_ENSP00000356087 QATCRR----------TLEVARTSLLYLS----SSLGTE-RFSSV------AGTPEIQELK----AAAELRSRLR-TLAEVL-SRCSQNITETQESLS---SLNRELVKSRDQVHED--- P_pygmaeus_ENSPPYP00000000308 QATCRR----------TLEVARTSLLYLS----SSLGTE-RFSSV------AGTPEIQELK----AAAELRSRLR-TLAEVL-SRCSQNITETQESLS---SLSRELVKSRDQVHED--- G_aculeatus_ENSGACP00000000783 KEDYSE----------ILHKKSEVFHLCN----FCTQILEKTEQL-FEALMQANVMSSEYD----EICDMHKKVL-RISGSL-EPIERTTQDIKSKFTSGGLLTDGWTQQVGTHPED--- T_rubripes_ENSTRUP00000005087 QKECGE----------VMHSIAMITIRLQ----SCLNLDHRIHTL------FRGHYASGNQ----SPADNSQKLK-SVHEHL-PIYAACIQEFQSRLD---HLQIEQAKLAEVLASD--- M_mulatta_ENSMMUP00000038190 QATCRQ----------TLEVARTSLLYLS----SSLGTE-RWVSV------AGMPEIQELK----VAAELRSRLR-TLAEVL-SRCSQNITETQESLS---SLSQELVKSRDQVHED--- O_latipes_ENSORLP00000019746 RADCSE----------ALHSLSLITLRFQ----SCFNAHNRIHKL------TRLFFVSPRL----PSFQPSSQLSPQVRERL-PLYTAGIKDCQNQME---HLLIEQAKLTETLASD--- O_cuniculus_ENSOCUP00000010441 XXXXXX----------XXXXXXXXXXXXX----XXXXXXXXXXXX-YEKLMKINLEAAELG----EISDIHTKLL-RXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--- P_pygmaeus_ENSPPYP00000005386 KDDYNE----------TVHKKTEVVITLD----FCVRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKD--- M_mulatta_ENSMMUP00000010063 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKD--- P_troglodytes_ENSPTRP00000008798 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIDSRLSPGGSLADGWAHQEGTHPKD--- E_caballus_ENSECAP00000018587 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTMKV-YEKLIEINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIESKLSPSGLLTDAWAHQEGTHPKD--- B_taurus_ENSBTAP00000046540 QATCRR----------TLELARMALLFLS----SSLGPE-RFSGL------AGVPELQDLK----RTAELRSRLR-NLAEVL-SRCSHNITETQKTLS---DLCSELVKNRDQVHED--- H_sapiens_ENSP00000329967 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKD--- C_familiaris_ENSCAFP00000000505 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIESKLSPGGLLSDTWAHQEGTHPKD--- R_norvegicus_ENSRNOP00000009260 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKVSLDAAELG----EISDIHTKLL-RLSSSQ-GTIESSLQDINSRLSPGGSLADTWAHQEGTHPRD--- M_musculus_ENSMUSP00000020316 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKVNLEAAELG----EISDIHTKLL-RLSSSQ-GTIESSLQDISSRLSPGGLLADTWAHQEGTHPRD--- A_carolinensis_ENSACAP00000003243 KEDYTE----------TLHKKTEVVLKLE----FCNRSIEKAVEI-YQNMLQNNLAPSEVD----EISDIHSKVL-RLSSSR-VTIETSLQEIKNKLSPSGLLSDSWTNQEGTHSKD--- E_caballus_ENSECAP00000000587 QATCRR----------TLEVTRMALLFLS----SSLGTD-RFSNG------AGTPEIQELK----RATELRSQLR-TLAGVL-SRCSHNITETQMSLS---SLSSELVKNRDQVHED--- T_guttata_ENSTGUP00000006693 KDDYNE----------IVHKKAEIVIRLD----FCSRNIEKAEKI-YENLMQINLEASEVD----EISEIHTKLL-RLSSSQ-GTIETSLQDIKTKLSPGGLLTDTWANQEGMHPKD--- X_tropicalis_ENSXETP00000015947 KEEYNE----------NVHRNTEVSLKLS----FCNRTIEKDLKT-YEQLIQTSVEP--------EVYVIHGKLL-NLSSTQ-ESLKSSLQEIKNKLTPGGVLMDSWINAEGTHSAD--- M_domestica_ENSMODP00000002458 KATCGR----------TLETTRTALLFLS----PSLGTD-GFASM------TGESEVPELK----EAGELRSKLQ-TINEVL-SRCSQNIVETQTSLI---SLSSELVKTWDQVHED--- B_taurus_ENSBTAP00000023134 KDDYNE----------TVHKKTEVVITLD----FCIRNIEKTVKV-YEKLMKINLEAAELG----EISDIHTKLL-RLSSSQ-GTIETSLQDIESKLSPGGLLADTWTHQEGTHPKD--- G_gallus_ENSGALP00000021757 AASPAR----------DDHSCSSLDIQDG----SHLASH-RYEAI------PGGSALPALK----DVAAVRIRLQ-RVAEEL-SQCSHSIFDFQGALD---GMVSELVQYGQQAHED--- G_gallus_ENSGALP00000015982 KDDYNE----------MVHKKTEVVIRLD----FCSRNIEKAEKI-YENLMQINLESSEVD----EISEINTKLL-RLSSSQ-GTIETSLQDIKTKLSPGGLLADTWANQEGTHPRD--- R_norvegicus_ENSRNOP00000030127 QNTCQQ----------TLEITRTALLFLS----SSLGTE-RLSSG------AGMLDIQELK----EATELRSRLQ-TFSEVL-SKCSHNVTETQRSLS---CLVGELLKSRDQIHEDN-- X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 QDTCQQ----------TLEVTRTALLYLS----SSLGTE-RFSSG------AGMPDVQERK----EATELRTRLQ-TLSEIL-SKCSHNVTETQRSLS---CLGEELLKNRDQIHEDN-- D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 KSSCGH----------SLEKTRMALLFLN---HSGQGQD-RPQLT------SGSCEEPERR----VVGELRARLQ-TISEIL-SGWPQSIQDTWSRLG---SMAAELAKSREQVHEDR-- C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ----------------------------------------------------DLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAP-PKKGLLQRLF O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ----------------------------------------------------NLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLN-RSHPPEP-PKKGLLQRLF T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 -----------------------------------------------------------------HIRKLGQSPEGEEASRQGMTRHSHPGLGTSQSPKW-------------------- M_musculus_ENSMUSP00000110117 -----------------------------------------------------------------HIRKLGQSPEGEEASRQCMTRHSHPGLGTSQSPKW-------------------- M_mulatta_ENSMMUP00000008885 VQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQ-- M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 VQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQ-- T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 IQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQ-- R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 IQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQ-- P_pygmaeus_ENSPPYP00000003153 ----------------------------------------------------NLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLSPDLN-RNHPPEP-PKKGLLQRIF M_mulatta_ENSMMUP00000006107 ----------------------------------------------------NLDHTDDDFYSKFSTGSVSIPWQNE-IETECFKELNVFGPDGTLSPDLN-RNHPPEP-PKKGLLQRIF H_sapiens_ENSP00000358104 ----------------------------------------------------NLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-RNHPPEP-PKKGLLQRLF P_troglodytes_ENSPTRP00000005279 ---------------------------------------------------------------KFSTGSVSIPCSNEMIETECFKELNVFGPNGTLSPDLN-RNHPPEP-PKKGLLQRLF O_cuniculus_ENSOCUP00000001738 VQGKVKAADQEESTEVALYLLALLVFRLQDLPCGMEKLGGEVATLFTHSHVVSVVSAAACLLGQLGQQGVAFELQPAEWMAAATHALSAPAEXXXXXXXXXXXXXXXXXXXXXXXXXQ-- B_taurus_ENSBTAP00000038069 AQGKVKVVDREESTEVTLYLLSLLVLRLQDLPCGMEKLGSEIATVFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPGEWIAAATHALSAPAEVRLTPPGGCGFYDGLLILLLQLLTQQ-- C_familiaris_ENSCAFP00000017912 ----------------------------------------------------NLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPNGTLSPDLN-RSHPPEP-PKKGLLQRIF E_caballus_ENSECAP00000008449 VRGKVKVVDWEESAEVTLYLLSLLVLRLQDLPSGMEKLGGEIATVFTRSHVVSLVSAAACLLGQLGQQGVPFDLQPVEWIAAATHALSAPAEVRLTPPDGCGFYDGLFILLLQLLSQE-- B_taurus_ENSBTAP00000053464 ----------------------------------------------------ELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAP-PKKGLLQRLF M_musculus_ENSMUSP00000084430 VQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHVVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPYSCGFYDGLLILLLQLLMQVQ- R_norvegicus_ENSRNOP00000022839 VQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHIVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPCSCGFYDGLLVLLLQLLTQVQM G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ----------------------------------------------------DLEPTDQDFYQKFATGSVSIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPTAP-PKKGLLQRLF B_taurus_ENSBTAP00000001970 ----------------------------------------------------QLDSTDSCFYSEFVTGCVSIPWQNEMIESECFKDINESENEPVVVLEPDEKTDQQVPRQKRGFFYRLF A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 RGECEE----------AVHTIAMITIRLQ----CCLTTEQRTHTL--------ACYDAENK----GSTESRQRLH-LVREHL-PIYSAGIHEFHSRLN---HLQIEQAKLAETLAND--- M_domestica_ENSMODP00000006295 -----------------------------------------------------------------HMRRL-----------QLGTSQDGPGPGQATSHGELLAPETSGDPHVGCCRDCCA A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D P_troglodytes_ENSPTRP00000055512 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D M_mulatta_ENSMMUP00000024306 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D C_familiaris_ENSCAFP00000014093 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D B_taurus_ENSBTAP00000009985 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D P_pygmaeus_ENSPPYP00000002975 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D R_norvegicus_ENSRNOP00000034134 -RQGDLMESLEQRAID-LYKQLKHR----PTDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D M_musculus_ENSMUSP00000026217 -RQGDLMESLEQRAID-LYKQLKHR----PPDHLYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D E_caballus_ENSECAP00000005937 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D M_domestica_ENSMODP00000013213 -RQEDVMESLEQKAID-LYKQLKPR----SPDHSYSDSSEMVK----------IIVLT----------VQNQDRVLKE--LFGHLSKLLGCKQK----II-------------------D G_gallus_ENSGALP00000005196 -RQGEVMESLEQRAID-LYKQLKTR----PPDHAYSDSTDMVK----------IIVQT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D O_anatinus_ENSOANP00000003934 -RQGDVMETLEQKAID-LYKQLKHR----SPDHSYSDSTEMVK----------IIVQT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D T_guttata_ENSTGUP00000004836 -RQGEVMESLEQRAID-LYKQLKAR----PPDHAYSDSTDMVK----------IIVQT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D A_carolinensis_ENSACAP00000011973 -RQGDLMENLEQRAIE-LYKQLKRR----PPDHSYSDSTEMVK----------IIVQT----------VQSQDWVLKE--LFRHLSKLLDCKQK----II-------------------D X_tropicalis_ENSXETP00000038296 -RQGDVMEHLEQRAME-LYKQLKPR----SPDKAYSDSTEMVK----------ILVQT----------VQGQDRVLKE--LFGHLSKLLGCKQK----II-------------------D T_rubripes_ENSTRUP00000022821 -RQGDKMEQLEEKAIE-LYKQLKMKCKTPETDMS-TDSTEMVK----------AIIQT----------VQNQDKVLKD--LYTHLSKILISKQK----II-------------------D D_rerio_ENSDARP00000013115 -RQGDVMEQLQEKAIE-LYKQLKAKCKMPDPQHGYSDSSEMVK----------VIVQT----------VQNQDRVLRD--LYAHLSKILLSKQK----II-------------------D T_nigroviridis_ENSTNIP00000014802 -RQGDKMEQLEEKAIE-LYKQLKMRCKTPETDTS-TDSTEMVK----------AIIQT----------VQNQDKVLKD--LYTHLSKILISKQK----II-------------------D O_latipes_ENSORLP00000016017 -RQGDKMEQLEEKAIE-LYRQLKMKCKIPDSDVS-SDSSEMVK----------AIIQT----------VQNQDKVLKD--LYTHLSKILISKQK----II-------------------D G_aculeatus_ENSGACP00000005520 -RQGDKMEQLEEKAIE-LYKQMKMKCKTPEPDVS-SDSSQMVM----------AIIQT----------VQNQDKVLKD--LYTHLSKILISKQK----II-------------------D G_aculeatus_ENSGACP00000008884 -RQGDVMEQLEEKAIE-LYKQLKG----PDPPHGYSDSSDMVR----------MILQT----------VQNQDRVLKD--LYTHLSTILVCKQR----IV-------------------D T_rubripes_ENSTRUP00000036336 -RQVDVMEQLEEKAIE-LYKQLKAKC--PDPPHGYSDSSDMLK----------VILQM----------VQNQDRVVKD--LYTHLSTILVCKRR----IV-------------------D G_gorilla_ENSGGOP00000008804 -RQGDLMESLEQRAID-LYKQLKHR----PSDHSYSDSTEMVK----------IIVHT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D O_latipes_ENSORLP00000011761 -RQGDVMEQLEKKAIE-LYRQLKAKCKSPDPPHGYSDSSDMVK----------TILQT----------VQNQDRVLKD--LYTHLSTILVCKQH----IV-------------------D T_nigroviridis_ENSTNIP00000019642 -KQVDVMEQLEEKAIE-LYKQLKG----PDPPHGYSDSSDMLK----------IILQM----------VQNQDRVVKD--LYTHLSTILVCKRR----IV-------------------D M_mulatta_ENSMMUP00000010949 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E H_sapiens_ENSP00000339151 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E M_musculus_ENSMUSP00000033939 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E C_familiaris_ENSCAFP00000008270 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTDGDSQEMVR----------LLLQA----------IQGFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E A_carolinensis_ENSACAP00000012680 -KQGSSLDDLEEQARD-LYRKLREK---PRDQRTSGDSQEVVR----------LLLQA----------IQTFEKKVRL--LYVQLSNTVVCKQK----AL-------------------E R_norvegicus_ENSRNOP00000025851 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQDMVR----------LLLQA----------IQSFEKKVRV--IYSQLSKTVVCKQK----AL-------------------E G_gallus_ENSGALP00000005924 -KQGGTLEDLEEQARE-LYRRLREK---PRDQRTSGDSQEIVR----------LLLQA----------IQTFEKKVRV--IYAQLSKTVVCKQK----AL-------------------E O_anatinus_ENSOANP00000001111 -KQGGNLDDLEEQARE-LYRKLREK---PRDQRTSGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYNQLSKTVVCKQK----AL-------------------E P_troglodytes_ENSPTRP00000034602 ----------EEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVICKQK----AL-------------------E O_latipes_ENSORLP00000003067 -RCGEALDTLEGKAME-LFRKLREK---PRDQRCAGDGQEVMR----------LVLQA----------VQVYERKLKD--FYTHLSKTAVCRQR----VM-------------------E B_taurus_ENSBTAP00000049055 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTDGDSQEMVR----------LLLQA----------IQGFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E M_domestica_ENSMODP00000012792 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTDGDSQEMVR----------LLLQA----------IQSFEKKVRA--IYMQLSKTMVCKQK----AL-------------------E X_tropicalis_ENSXETP00000036619 -KHRGTLDDLEEQAKD-LYRRLRER---PRDQRTAGDSNEMVR----------LLIQA----------IQSFEKRVIL--IYDQLSKTVACKHK----AL-------------------E P_pygmaeus_ENSPPYP00000020804 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E O_cuniculus_ENSOCUP00000011297 -XXXXXXXXXXXXXXX-XXXXXXXX----XXXXXXXXXXXXXX----------XXXXX----------XXXXXXXXXX--XXXXXXXXXXXXXX----XX-------------------X G_aculeatus_ENSGACP00000005440 -RSGEALDTLEGKAME-LFRKLREK---PRDQRLPGDSQEVVR----------LVLQA----------VQFYERKLRD--FYTHLSKTAVCRQR----VM-------------------E T_guttata_ENSTGUP00000016868 -RQGEVMESLEQRAID-LYKQLKAR----PPDHAYSDSTDMVK----------IIVQT----------VQSQDRVLKE--LFGHLSKLLGCKQK----II-------------------D T_nigroviridis_ENSTNIP00000019003 -RSGEALDTLEGKAME-LFRKLREK---PRDQRCSGDSQEVVR----------LVVQA----------VQFYEKKLRD--FYTHLSKTAACRQR----VM-------------------E E_caballus_ENSECAP00000003662 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTDGDSQEMVR----------LLLQA----------IQGFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E T_rubripes_ENSTRUP00000041917 -RSGEALDTLEGKAME-LFRKLREK---PRDQRCSGDSQEVVR----------LVVQA----------VHFYERKLRD--FYTHLSKTALCRQR----VM-------------------E G_gorilla_ENSGGOP00000006628 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTEGDSQEMVR----------LLLQA----------IQSFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E O_cuniculus_ENSOCUP00000006175 -KQGGTLDDLEEQARE-LYRRLREK---PRDQRTDGDSQEMVR----------LLLQA----------IQGFEKKVRV--IYTQLSKTVVCKQK----AL-------------------E T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA -RGYDQHDPFNLKSLDNRYEIARVQ--ILEKNTHEKSHIDMLQ----------AVYEC----------LKKRDILLRDYSFKELQQQLIDIRRE----MQ-------------------E A_gambiae_AGAP009166-PA -QEYEQQDYFGLKTVEGRYEQTRAR--ILEKITNEKSHMDMSQ----------AVYEC----------LKRRDVLLRDAGFLELQRQLLDVRHE----MQ-------------------E A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 -----------------FYKKYLCNGAIISPSELNNDAEEFAK----------SRFKL----------YNEGEAR--------HLPKSID------------------------------ A_aegypti_AAEL005359-PA -RVNEKAKYLVDRLRD-SWQHLLRDRATRSLTHNDEQFHALEK----------IKITE----------TGKRVKTLLNDDVRPAVEQEAESLAD----WY------------KKAQ---T A_gambiae_AGAP009565-PA -RDSEKAKSLVDRLRD-SWQHMLRDRATRSLTYNDEQFHVLEK----------VKIAE----------TGKRLKTLLNDGVRQAVEQEAECLAD----WY------------KKAQ---T A_carolinensis_ENSACAP00000012863 -RSIQKMEACLDKMQL-IYAQFKKARKCPRLGYNEQQIHKLDK----------LNLGH----------SAKKVILVFQDNSEHQYRAALSGHGT----RM------------R------- C_intestinalis_ENSCINP00000011687 -RLEERMKVASEKSRE-ISRLFKTHKKIRRLSHSDDQLHKFEK----------QRLAE----------VCEASVTLFTDKSVPGCKRLHKESIN----WF------------SNMN---E D_rerio_ENSDARP00000014302 -KSIQKMEVLLSQIVD-VHFQYFRDRQTRKLGYNDEQIHKFEK----------LNLSS----------YLKKFKSLFKDDCFQKYLDVLNTTDR----CS------------RALY---D D_rerio_ENSDARP00000074566 -KSIQKMEVLLSQIVD-VHFQYFRDRQTRKLGYNDEQIHKFEK----------LNLSS----------YLKKFKSLFKDDCFQKYLDVLNTTDT----CS------------RALY---D D_melanogaster_FBpp0080920 -RASAQAKYLVERLRD-SWQHLLRDRATRTLTYNDEQFHALEK----------IKVDH----------NGKRIKALLLDNVNPTVAQIAECLAD----WY------------KLAQ---T D_rerio_ENSDARP00000087779 -----ICSFIHPSICS-FIHSF-------IYLFIHSSVHSFIH----------SSIHLLIYLFIHSSVHPSIHPSVQSFICSSVHPSIHPSIHPSFHLFI------------CSFI---H T_nigroviridis_ENSTNIP00000005945 -RNVEKIKVLLDAITA-IYQQFKKDKAERRLPYNEEQIHKFDK----------QKLVL----------HASKARSLFTEECAMKYRLFISKSEE----WL------------RKVH---H H_sapiens_ENSP00000356087 -RSIQQIQCCLDKMNF-IYKQFKKSRMRPGLGYNEEQIHKLDK----------VNFSH----------LAKRLLQVFQEECVQKYQASLVTHGK----RM------------RVVH---E P_pygmaeus_ENSPPYP00000000308 -RSIQQIQCCLDKMNF-IYKQFKKSRMRPGLGYNEEQIHKLDK----------VNFSH----------LAKRLLQVFQEECVQKYQASLVTHGK----RM------------RVVH---E G_aculeatus_ENSGACP00000000783 -RNVEKIKVLLDAITA-IYQQFKKDKAERRLPYNEEQIHKFDK----------QKLVL----------HATKARSLFTEECAMKYRLFISKSEE----WL------------KKVH---H T_rubripes_ENSTRUP00000005087 -KSCQKMQVLLQKITA-IHQHYRKDRLNGKLAYNDEQIHKFEK----------IHLSN----------HIKRVKSLFREDSVLRYKELLASTQI----WSRSEPVPSLTPGTCSLV---G M_mulatta_ENSMMUP00000038190 -RSIQQIQCCLDKMNF-IYKQFKKSRMRPGLGYNEEQIHKLDK----------MNFSH----------LAKRLLQVFQEECVQKYQASLVTHGK----RM------------RVVH---E O_latipes_ENSORLP00000019746 -KSCQKMEMLLQKIVA-IHQQYRKDRLIGKLAYNDEQIHKFEK----------LHLLS----------HIKRVKSVFREECVQRYKELLGSTKT----WS------------RALQ---E O_cuniculus_ENSOCUP00000010441 -XXXXXXXXXXXXXXX-XXXXXXXXXXXXXLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFSDECVKKYEAFLDKSEE----WM------------RKML---H P_pygmaeus_ENSPPYP00000005386 -RNVEKLQVLLNCMTE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEAFLNKSEE----WI------------RKML---H M_mulatta_ENSMMUP00000010063 -RNVEKLQVLLNCMTE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEAFLSKSEE----WM------------RKML---H P_troglodytes_ENSPTRP00000008798 -RNVEKLQVLLNCMTE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEAFLNKSEE----WI------------RKML---H E_caballus_ENSECAP00000018587 -RHVEKLQVLLSCITE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEVFLDKSEE----WM------------RKML---H B_taurus_ENSBTAP00000046540 -RSIQQIQCCLDKMYL-TYKQFKKSRMRPGLGYNEEQIHKLDK----------APAER----------EAVLEEQKPQQSCVQKPPLWGLRWGH----VA------------WLVD---E H_sapiens_ENSP00000329967 -RNVEKLQVLLNCMTE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEAFLNKSEE----WI------------RKML---H C_familiaris_ENSCAFP00000000505 -RHVEKLQVLLNCITE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYETFLDKSEE----WM------------RKML---H R_norvegicus_ENSRNOP00000009260 -RNVEKLQVLLNCITE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVRKYEAFKDTSEE----WM------------RKML---H M_musculus_ENSMUSP00000020316 -RNVEKLQVLLNCITE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMSHFSEECVRKYEAFKDKSEE----WM------------RKML---H A_carolinensis_ENSACAP00000003243 -RNPERLQVLLGSITD-IYHQFKKDKAERRLLYNEEQIHKFDK----------QKLFL----------HATKAMTLFKEECVSKYEAFLDKAED----WT------------RQDPFMHH E_caballus_ENSECAP00000000587 -RSTQKIQCCLDKMYL-IYKQFKKSRVRPGLGYNEEQIHKLDK----------VNFSH----------LAKRLLQVFQEECVQKYQTSLVTHGK----HM------------RVVH---E T_guttata_ENSTGUP00000006693 -RNPERLQALLSSITD-IYYQFKKDKAERRLPYNEEQIHKFDK----------QKLYL----------HATKAIALFKDECVSKYDAFLDKAED----WT------------RQAIDFFN X_tropicalis_ENSXETP00000015947 -RNVEKLQVLLSLITE-IYCQFKKDKAQRRLLYNEEQIHKFDK----------QKMCI----------HSTKAYSLFKDECVGKYEGFRSKALD----WM------------RKMI---H M_domestica_ENSMODP00000002458 -RSTQQIQCCLDKMNL-IYKQFKKARMRPGLGYNEEQIHKLDK----------VNFGH----------LAKRLLVLFQEDCVQKYQAALLTHGK----RM------------RTVH---E B_taurus_ENSBTAP00000023134 -RHVEKLQVLLNCITE-IYYQFKKDKAERRLAYNEEQIHKFDK----------QKLYY----------HATKAMTHFTDECVKKYEAFLDKSEE----WM------------RKML---H G_gallus_ENSGALP00000021757 -K---------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000015982 -RNSERLQTLLSAITD-IYYQFKKDKQERRLAYNEEQIHKFDK----------QKLYL----------HATKAIALFKDECVSKYDAFLDKAED----WT------------RKML---H R_norvegicus_ENSRNOP00000030127 -RSIQKIQCCLDKMHF-IYKQFKKSRMRPGLSYNEEQIHKLDK----------VNFSH----------LAKRLLQVFQEECAQTYQVSLVTHGK----RM------------RQVQ---K X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 -KSIQKIQCCLDKMHF-IYKQFKKSRMRPGLSYNEEQIHKLDK----------VNFSH----------LAKRLLQVFQEECVQTYQVSLVTHGK----RM------------RQVQ---R D_rerio_ENSDARP00000036490 --EGEGEPASKRKPGP-------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000008566 -SSIQQIECCLDKMQL-IYKQFKKARMRPGLGYNEEQIHKLDK----------VNFVH----------LAKRLLRIFQDDCVHKYQEALTMHGQ----RM------------REVH---E C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 SRQQLIAVGTAATVKK------SSPPASSPQAEAPTGGWR-------------------------------------------------------------------------------- O_latipes_ENSORLP00000008832 -EEEEIRVSFSEKCAKEFAEF--------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000010492 KRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 GKAGLIRDVASSEMWTVLWHRFSTVLRLPKEASAQEGELLLSNPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRHAPHGSEFLPVVVLS M_musculus_ENSMUSP00000005164 -EEEEIRVSITEKCGKEFCEF--------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 GKASLIRDMSSSEMWTVLWHRFSMVLRLPKEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFAQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLS T_nigroviridis_ENSTNIP00000013350 -DEEEIRVSFTEKCAKEFAEF--------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000295709 GKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLS R_norvegicus_ENSRNOP00000043572 -EEEEIRVSITEKCGKEFCEF--------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000022091 GKASLIRDMCSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLS P_pygmaeus_ENSPPYP00000003153 KRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000006107 KRQHQNNSKSSPSSKTNFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- H_sapiens_ENSP00000358104 KRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000005279 KRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000001738 GKARLIRDVAGSELWTILWHRFSMALRLPEEVPTLEEELLLSVPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSHLSQRGNILMSTLKHLLSPNFLHHLGQAPHGPEFLPVVVLS B_taurus_ENSBTAP00000038069 GKGNPIRDMASSEMWTVLWHRFFMALRLPEEASTQEEEVSLSSPQSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHHLGQAPQGSEFLPVVVLS C_familiaris_ENSCAFP00000017912 KRQHQNNSKSSPNPKTSFNHHINSNHVSSNSTGS-----S-------------------------------------------------------------------------------- E_caballus_ENSECAP00000008449 GKGSLIREVASSEMWTVLWQRFSMALRLPEEVSAQEEELSLCSPQSPGPDWTLISPQGMAALLSLAVASFTQEPQLCLSHLSQRGSILMSTLKHLLSPSFLHQLGQAPHGSEFLPVMVLS B_taurus_ENSBTAP00000053464 SRQR-TAVETAATVRKSFPPASSSPPASSPQPGAPPGGWR-------------------------------------------------------------------------------- M_musculus_ENSMUSP00000084430 GKPGLIRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLLSSPSSLEPDWTLISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQGPEFLPVVVLS R_norvegicus_ENSRNOP00000022839 GKPGLIRDVAGSEVWTILWHRFSMALRLSEEVSAQEDDLSLSSPPSLEPDWTLISPQGMAALLSLAMAIFTQEPQLCLSHLSQHGSVLMLTLKHLLSPSFLHRLSQAPQGSEFLPVVVLS G_gallus_ENSGALP00000014351 -EEEDIRASLTEKCAKEFADF--------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006845 -EEEDIRASLTEKCAKEFADF--------------------------------------------------------------------------------------------------- C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 SRQR-IAVGTAATVRK------SSPPASSPQAEAPTGGWR-------------------------------------------------------------------------------- B_taurus_ENSBTAP00000001970 SRGGCFNAGSSKKKLVSSRR---------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000005713 -EEEDIRVSLTEKCAKEFADF--------------------------------------------------------------------------------------------------- A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 -QSCQKMEMLKQRITT-IHQHYRKDRQTGKLAYNDEQIHKFEK----------IHLSS----------HIKRVKSLLREDCVLRYKELLATTKK----WS------------SVLL---E M_domestica_ENSMODP00000006295 ESAPELPATRPPQL---------------------------------------------------------------------------------------------------------- A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 LLPKVEMALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 LLPKVEMALSNIKEADSTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 LLPKVEMALSNIREADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 LLPKIEVALNSIKEADNMVMLMQGKRQR-------EI-WHLL------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 LLPKIEVALNNIKEADNSVMQMQGKRQR-------EI-WHLL------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 LLPKVEVALNNIKEADNTVMLMQGKRQR-------EI-WHLL------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 LLPEIEVALNNIKEADNSVMQMQGKRQR-------EI-WHLL------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 LLPKIEVALNNIKEADNSVMQMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 LLPQIEMTVNNIKEADSSLMQMQAKRQR-------EI-WHLL------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 LFPRIEKTLENIKDADTTVMQMQIKRQR-------EF-WHLL------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 LFPKIERTLECIKEADTTVMQMQIKRQR-------EF-WHLL------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 LFPRIEKALENIKDADTTVMQMQTKRQR-------EF-WHLL------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 LFPRIEKTLENIKDADNTVMQMQIKRQR-------EF-WHLL------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 LFPRIEKTLESIKDADNTVMQMQIKRQR-------EF-WHLL------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 LFPKLERAVENIKTAEAAVMQMQMKRQK-------EF-WYLL------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 LFPKLETAVTDIKNAEAGVVQMQMKRQK-------EF-WFLL------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 LLPKVEVALSNIKEADNTVMFMQGKRQK-------EI-WHLL------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 LFPHLEKALGDIKATENTVIQMQKRRQK-------EF-WYLL------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 LFPKLETAVTDIKSAETGVMQMQMKRQK-------EF-WFLL------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ H_sapiens_ENSP00000339151 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 LLPKVEEVVSLMNEDERTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 LFPKVDEVMSLMKEDEKTVVGLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 LLPKVEEVVRLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 LFPRVEKVMNLMNEDEETVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 LFPKVEEVMSLMNEDEKTVVQLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 LLPKVEGVVQKMAESEQILMSLQERRQK-------EL-WNLL------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 LLPKVEEVVSLMSEDEKMVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 LLPQVEEVVSLMNEDEKTVVQLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 LSPKVKEVMNLMREDEKMVVKRQEKRQQ-------EL-WNLL------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 LLPKVEELVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 XXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XX-XXXX------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 LLPKVEGMVQSMVESEQVLMSLQERRQR-------EL-WNLL------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 LLPEIEVALNNIKEADNSVMQMQGKRQR-------EI-WHLL------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 LLPKVEGVVQKMAESEQVLMHLQEKRQR-------EL-WNLL------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 LLPKVEGVVQKMAESEQVLIRLQEKRQR-------EL-WNLL------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 LLPKVEEVVSLMNEDEKTVVRLQEKRQK-------EL-WNLL------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA IRKALDKAQEHAEKFKKDLAKMIVEHNN-------SV-WSLL------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA IEKVLEKVVELTEKYKRELARLTLEHQD-------EV-WKML------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ---HMHYLYFKTKESIPVLLQQFCDIKK-------EI-FQI------------------------------------------------------------------------------- A_aegypti_AAEL005359-PA IFLQTKFLFKDVGSHEDTLYDIRVRLVQ-------IK-EDLK------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA IFLQTQFLTKDVGAYVDALYELREQLKQ-------HR-EDLK------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 YQKKLWNCETRIMRLSDRCQEQEESIRTLQRVYRDKL--SLV------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 MQTHLDKFRDTLLQRIQDLKAHEILQNK-------VL-ERVV------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 MQTHLDKFRDTLLQRIQDLKAHEILQNK-------VL-ERVV------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 VYLKTQILEKDVRDCERKLNGIRDELYH-------VK-SELK------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 PSIHLFIHSSVHSSIHSFICSFIHLIYL-------FI-HSFI------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 VRKQLLTLSAQLIGIEKEVAMLMERGIK-------LQ-EQLP------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 TRNHLRLVGCSVAACNTEAQGVQESLSK-------LL-EELS------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 TRNHLRLVGCSVAACNTEAQGVQESLSK-------LL-EELS------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 VKKQLLGLSGQLISIEKEVTMLMERAIK-------LQ-EHLP------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 CKSKFKN-----ADPAAGVQLFLHRLVG-------RLGDEIL------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 TRNHLRLVSCSVAACNTEAQGVQESLSK-------IL-EELS------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 MENRLLGFGSLSTGLLTDLEMDEMHYNK-------IM-DNIL------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 LRKQLLSLTNQCFDIEEEVSKYQDYTN--------LQ-ETL------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005386 LRKQLLSLTNQCFDIEEEVSKYQEYTNE-------LQ-ETLP------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 LRKQLLSLTNQCFDIEEEVSKYQDYTNE-------LQ-ETLP------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 LRKQLLSLTNQCFDIEEEVSKYQEYTNE-------LQ-ETLP------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 LRKQLLALTNQCFDIEEEVSKYQDYTSE-------LQ-ETLP------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 TRSHLRLVGCSVAACNTEAQGAQESLSK-------IL-DRLS------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 LRKQLLSLTNQCFDIEEEVSKYQEYTNE-------LQ-ETLP------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 LRKQLLSLTNQCFDIEEEVSKYQDYTNE-------LQ-ETLP------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 LRKQLLSLTNQCFDIEEEVSKYQDYTNE-------LQ-ETLP------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 LRKQLLSLTNQCFDIEEEVSKYQDYTNE-------LQ-ETLP------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 LRKQLMTLRKLCFDIEKEVSKYQDYVDK-------LQ-ENLP------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 TRNHLRLVGCSVAACNTEAQGAQESLSK-------LL-DRLS------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 IWKQLLALTNQCFGIEEEVSKYQDYINE-------LQ-DALP------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 VRKQLFSLKSQCFEIEEEVSKCQHYINQ-------YQ-EKMS------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 TRKHLRLVSSSVTACKAEAQEAQGQLSKKRISSSQAL-DRLS------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 LRKQLLSLTNQCFDIEEEVSKYQEYTNE-------LQ-ETLP------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 TRKQLLALTNQCFDIEEEVSKYQDYINE-------LQ-DALP------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 AQNHLHLIGHSVATCNSEARGAQESLAK-------MF-D--------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 AQNHLHLIGHSVATCNSEARGAQESLNK-------IF-D--------------------------------------------------------------------------------- D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 IRKHLQLVNSTVAACSSEAQGTQECLRE-------VM-SFWG------------------------------------------------------------------------------ C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 VCQLLCFPFALDVDADLLIDILADLRDSEVAAHLLQVCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSYLSFIQEL M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 VCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLTQVELPISLLTRLALTDPTSLNQFVNTVAASPRTIISFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQEL T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 VCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQEL R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 VCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQEL P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 VCQLLCFPFSLDVDADLLVGILADLRDSEVAAHLLQVCCHRLPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX B_taurus_ENSBTAP00000038069 VCQLLCFPFALDVDADLLEGVLADLTDSEVTAHLLQVCCHHLPLTQVELPISLLTRLALSDPAFLNQFVNTVVASPRTTVSFLSTALLGDQPLLTSDLLSLLAHTARLLSPSHLSFIHEL C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 VCQLLCFPFALDVDADLLVGVLADLTNSEVTAHLLQVCCHHLPLPQVELPISLLTHLALMDSTSLNQFVNTVAASPRSMISFLSIALLGDQPLLTSDLLSLLAHTVRVLSPSHLSFIQEL B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 VCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMISDLLSLLTHTARILSPSHLSFIQEL R_norvegicus_ENSRNOP00000022839 VCKLLCFPFALDVDADLLGGILADLRASEVAVYLLQVCCHHLPLFQAELPIGLLTRLALMDPTSLKQFVNTVATSSRAIISFLSVVLLCDQPLMVSDLLSLLTHTTRILSPSHLSFIQEL G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 MKTRLQDFSSFSTDLLAEVEMNEHHLNK-------AL-DRIL------------------------------------------------------------------------------ M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 ----------------------------------------------------------------------------------------------------------------------K- P_troglodytes_ENSPTRP00000055512 ----------------------------------------------------------------------------------------------------------------------K- M_mulatta_ENSMMUP00000024306 ----------------------------------------------------------------------------------------------------------------------K- C_familiaris_ENSCAFP00000014093 ----------------------------------------------------------------------------------------------------------------------K- B_taurus_ENSBTAP00000009985 ----------------------------------------------------------------------------------------------------------------------K- P_pygmaeus_ENSPPYP00000002975 ----------------------------------------------------------------------------------------------------------------------K- R_norvegicus_ENSRNOP00000034134 ----------------------------------------------------------------------------------------------------------------------K- M_musculus_ENSMUSP00000026217 ----------------------------------------------------------------------------------------------------------------------K- E_caballus_ENSECAP00000005937 ----------------------------------------------------------------------------------------------------------------------K- M_domestica_ENSMODP00000013213 ----------------------------------------------------------------------------------------------------------------------K- G_gallus_ENSGALP00000005196 ----------------------------------------------------------------------------------------------------------------------K- O_anatinus_ENSOANP00000003934 ----------------------------------------------------------------------------------------------------------------------K- T_guttata_ENSTGUP00000004836 ----------------------------------------------------------------------------------------------------------------------K- A_carolinensis_ENSACAP00000011973 ----------------------------------------------------------------------------------------------------------------------K- X_tropicalis_ENSXETP00000038296 ----------------------------------------------------------------------------------------------------------------------K- T_rubripes_ENSTRUP00000022821 ----------------------------------------------------------------------------------------------------------------------K- D_rerio_ENSDARP00000013115 ----------------------------------------------------------------------------------------------------------------------K- T_nigroviridis_ENSTNIP00000014802 ----------------------------------------------------------------------------------------------------------------------K- O_latipes_ENSORLP00000016017 ----------------------------------------------------------------------------------------------------------------------K- G_aculeatus_ENSGACP00000005520 ----------------------------------------------------------------------------------------------------------------------K- G_aculeatus_ENSGACP00000008884 ----------------------------------------------------------------------------------------------------------------------K- T_rubripes_ENSTRUP00000036336 ----------------------------------------------------------------------------------------------------------------------K- G_gorilla_ENSGGOP00000008804 ----------------------------------------------------------------------------------------------------------------------K- O_latipes_ENSORLP00000011761 ----------------------------------------------------------------------------------------------------------------------K- T_nigroviridis_ENSTNIP00000019642 ----------------------------------------------------------------------------------------------------------------------K- M_mulatta_ENSMMUP00000010949 ----------------------------------------------------------------------------------------------------------------------K- H_sapiens_ENSP00000339151 ----------------------------------------------------------------------------------------------------------------------K- M_musculus_ENSMUSP00000033939 ----------------------------------------------------------------------------------------------------------------------K- C_familiaris_ENSCAFP00000008270 ----------------------------------------------------------------------------------------------------------------------K- A_carolinensis_ENSACAP00000012680 ----------------------------------------------------------------------------------------------------------------------K- R_norvegicus_ENSRNOP00000025851 ----------------------------------------------------------------------------------------------------------------------K- G_gallus_ENSGALP00000005924 ----------------------------------------------------------------------------------------------------------------------K- O_anatinus_ENSOANP00000001111 ----------------------------------------------------------------------------------------------------------------------K- P_troglodytes_ENSPTRP00000034602 ----------------------------------------------------------------------------------------------------------------------K- O_latipes_ENSORLP00000003067 ----------------------------------------------------------------------------------------------------------------------K- B_taurus_ENSBTAP00000049055 ----------------------------------------------------------------------------------------------------------------------K- M_domestica_ENSMODP00000012792 ----------------------------------------------------------------------------------------------------------------------K- X_tropicalis_ENSXETP00000036619 ----------------------------------------------------------------------------------------------------------------------K- P_pygmaeus_ENSPPYP00000020804 ----------------------------------------------------------------------------------------------------------------------K- O_cuniculus_ENSOCUP00000011297 ----------------------------------------------------------------------------------------------------------------------X- G_aculeatus_ENSGACP00000005440 ----------------------------------------------------------------------------------------------------------------------K- T_guttata_ENSTGUP00000016868 ----------------------------------------------------------------------------------------------------------------------K- T_nigroviridis_ENSTNIP00000019003 ----------------------------------------------------------------------------------------------------------------------K- E_caballus_ENSECAP00000003662 ----------------------------------------------------------------------------------------------------------------------K- T_rubripes_ENSTRUP00000041917 ----------------------------------------------------------------------------------------------------------------------K- G_gorilla_ENSGGOP00000006628 ----------------------------------------------------------------------------------------------------------------------K- O_cuniculus_ENSOCUP00000006175 ----------------------------------------------------------------------------------------------------------------------K- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ----------------------------------------------------------------------------------------------------------------------N- A_gambiae_AGAP009166-PA ----------------------------------------------------------------------------------------------------------------------SS A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ----------------------------------------------------------------------------------------------------------------------ED A_gambiae_AGAP009565-PA ----------------------------------------------------------------------------------------------------------------------EE A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ----------------------------------------------------------------------------------------------------------------------ES D_rerio_ENSDARP00000014302 ----------------------------------------------------------------------------------------------------------------------HR D_rerio_ENSDARP00000074566 ----------------------------------------------------------------------------------------------------------------------HR D_melanogaster_FBpp0080920 ----------------------------------------------------------------------------------------------------------------------LD D_rerio_ENSDARP00000087779 ----------------------------------------------------------------------------------------------------------------------HL T_nigroviridis_ENSTNIP00000005945 ----------------------------------------------------------------------------------------------------------------------QK H_sapiens_ENSP00000356087 ----------------------------------------------------------------------------------------------------------------------HQ P_pygmaeus_ENSPPYP00000000308 ----------------------------------------------------------------------------------------------------------------------HQ G_aculeatus_ENSGACP00000000783 ----------------------------------------------------------------------------------------------------------------------QK T_rubripes_ENSTRUP00000005087 ----------------------------------------------------------------------------------------------------------------------YS M_mulatta_ENSMMUP00000038190 ----------------------------------------------------------------------------------------------------------------------HQ O_latipes_ENSORLP00000019746 ----------------------------------------------------------------------------------------------------------------------ST O_cuniculus_ENSOCUP00000010441 ----------------------------------------------------------------------------------------------------------------------QK P_pygmaeus_ENSPPYP00000005386 ----------------------------------------------------------------------------------------------------------------------QK M_mulatta_ENSMMUP00000010063 ----------------------------------------------------------------------------------------------------------------------QK P_troglodytes_ENSPTRP00000008798 ----------------------------------------------------------------------------------------------------------------------QK E_caballus_ENSECAP00000018587 ----------------------------------------------------------------------------------------------------------------------QK B_taurus_ENSBTAP00000046540 ----------------------------------------------------------------------------------------------------------------------HQ H_sapiens_ENSP00000329967 ----------------------------------------------------------------------------------------------------------------------QK C_familiaris_ENSCAFP00000000505 ----------------------------------------------------------------------------------------------------------------------QK R_norvegicus_ENSRNOP00000009260 ----------------------------------------------------------------------------------------------------------------------QK M_musculus_ENSMUSP00000020316 ----------------------------------------------------------------------------------------------------------------------QK A_carolinensis_ENSACAP00000003243 ----------------------------------------------------------------------------------------------------------------------HK E_caballus_ENSECAP00000000587 ----------------------------------------------------------------------------------------------------------------------QQ T_guttata_ENSTGUP00000006693 ----------------------------------------------------------------------------------------------------------------------QK X_tropicalis_ENSXETP00000015947 ----------------------------------------------------------------------------------------------------------------------PK M_domestica_ENSMODP00000002458 ----------------------------------------------------------------------------------------------------------------------RR B_taurus_ENSBTAP00000023134 ----------------------------------------------------------------------------------------------------------------------QK G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ----------------------------------------------------------------------------------------------------------------------QK R_norvegicus_ENSRNOP00000030127 -----------------------------------------------------------------------------------------------------------------------Q X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 -----------------------------------------------------------------------------------------------------------------------Q D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ----------------------------------------------------------------------------------------------------------------------CS C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 LAGSDESYRPLRSFLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNATYQAGPLGPALAVAVPSMTQLLGDPQAGIRRNVASALGNLGPEG M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 LAGSDESYQSLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 LAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 LAGSDESYRPLRSLMGHPENSVRAHTHR-VGHLLQHSMALR-----------------GDKDPFVRCSASFAVGNAAYQAGLLRPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEG P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX B_taurus_ENSBTAP00000038069 LAGSDESYRPLRSLLSHPETSVRARTYGLLGHLLQHSMALRGALQSQAGLLNLLLLGLGDKDPAVRRGASFAVGNAAYQAGPLGPALAAAVPGMTQLLEDPQAGIRRNAVSALGNLGPEG C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 LAGSDESYRPLRSW-AHPENSVRARTYGLLGHLLQHSMALRGALQ-QTGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPGMTQLLGDPQAGIRRNAASALGNLGPEG B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 LSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPEG R_norvegicus_ENSRNOP00000022839 LSGSDESYRPLRSLLGHSENAVRVRTYRLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDAIRRNAASALGNLGPEG G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ----------------------------------------------------------------------------------------------------------------------CT M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000359424 -----IAC-TQSSARSLVGSSL--EGAVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHLSTIIHEANEE-QGN----SMMNL-DWSWLTE------- P_troglodytes_ENSPTRP00000055512 -----IAC-TQSSARSLVGSSL--EGAVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHLSTIIHEANEE-QGS----SMMNL-DWSWLTE------- M_mulatta_ENSMMUP00000024306 -----IAC-TQSSARSLVGSSL--EGAVTPQTSVWLPPT-SA--EHDHSLSCVVT----PQDG--DTSAQMIEENLNCLGHLSTIIHEANEE-QGN----SMMNL-DWSWLTE------- C_familiaris_ENSCAFP00000014093 -----IAC-TQSSARSLVGSSL--EGAVTPQASAWLPPN-SA--EREHPLSCVVT----PQDG--ETIVQMIEENLNCLGHLSTIIHEANEE-QGS----RMMNL-DWSWLTE------- B_taurus_ENSBTAP00000009985 -----IAC-TQSSARSLVGSSL--EG-VTPQ----LPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHLSTIIHEANEK-QGN----NMMSL-DWSWLTE------- P_pygmaeus_ENSPPYP00000002975 -----IAC-TQSSARSLVGSSL--EGAVTPQASAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIAENLNCLGHLSTIIHEANEE-QGS----SMMNL-DWSWLTE------- R_norvegicus_ENSRNOP00000034134 -----IAC-TQSSARSLVGSSL--EGTVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHLSTIIREANED-QSS----SMMSL-DWSWLAE------- M_musculus_ENSMUSP00000026217 -----IAC-TQSSARSLVGYSL--EGTVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHLSTIIREANED-QSS----SLMSL-DWSWLAE------- E_caballus_ENSECAP00000005937 -----IAC-TQSSARSLVGSSL--EGAVTPQASAWLPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHLGTIIREANEE-QGS----RMMNL-DWSWLTE------- M_domestica_ENSMODP00000013213 -----IAC-TQSSARSLVGTSL--EGAATSPPSAGLPSALTA--PMPRSLSCVLS----AQDG--ETFTQIVEENLNYLGCLSTVIREATEE-QGK----NLMSL-DWSWLK-------- G_gallus_ENSGALP00000005196 -----IAC-TQSSSRSLVSSSL--EGTASTPAATWVPQS-SS-EYAPHPLSSMAT----PGDG--ENFVDVIEENLNYLDRFSSMLQEAREE-QNN----SLTNF-DWSWL-K------- O_anatinus_ENSOANP00000003934 -----IAC-TQSSARSLVGSSL--EGAVPPPTPAWLPASATE--TVPHPFSSLVT----PKDG--ENFTQMIEENLNYLGCFSTIIREAKEE-QGN----SMMSL-DWSWLNQ------- T_guttata_ENSTGUP00000004836 -----IAC-TQSSSRSLVSSSL--EGTASSPAATWLPQS-SS------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 -----IAC-TQSSAKSPVSSN----GEVTSSVPACLSQTPSG--NVLQPLSSMET----SRNL--VPFAHLIEENLSYLHSFSTVIQEATHG-QSS----SLKSL-DWSWL--------- X_tropicalis_ENSXETP00000038296 -----IAC-TQSSARSLGPASV--ETPITPRTSAWPDQS-SS-----QALFSMLT----TKDKSREILRHTIDKNSDYQKLLSSLILQTQTTMEQN----SLMSL-DFSWLNK------- T_rubripes_ENSTRUP00000022821 -----IAC-AQNSSRSSMAASP--ESSTMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQLTSLMQEAADE-QSK----SIVDQ-DWSWTKYETLTDKL D_rerio_ENSDARP00000013115 -----IAC-AQNTTRSSVSQSG--EMPSSL--STWNQTQAQC--SSRLPM-SLQV----PHEG--DSVNHLLEENQRYLTQLTSLLQETTEE-KSE----SIMAQ-DWSWTKYESLVAKS T_nigroviridis_ENSTNIP00000014802 -----IAC-AQNSSRSSIAASP--ESSTMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQLTSLMQEGCGR-TVQKGVSSFKDQ-DWSWTKYETLSTKL O_latipes_ENSORLP00000016017 -----IAC-AQNSSRNSIAVSP--ESSNLLQVSQWSQSAQPV--SSPHPLVSLPG----PNDS--DAAPRLLQENQKYLSQLTSLMQEAADD-QAK----SIVDQ-DWSWTKYESLSTKL G_aculeatus_ENSGACP00000005520 -----IAC-AQNLTRNSIAASP--ESSNLLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENERYLCQLTSLMQEATDE-QTK----SIVEQ-DWSWTKYETLTTKL G_aculeatus_ENSGACP00000008884 -----IAC-NNTPTQSLMQQPT--YCAYSRPEIVW-RLNTYA--NTKRPYTVHTG----ACGI--ETVSQLLDENQRYLSQLTSLVQDATQE-MEH----SIMDQ-DWGWTKYGAAKAKP T_rubripes_ENSTRUP00000036336 -----IAC-TVKMTRALVKRVA--NTA---TICVF-RLIPVL--RHSHSHNNHVT----G-----ESVHQLLEENENYLSQLTSLLQETTRD-PEY----SIMEQ-DWSWTQC------- G_gorilla_ENSGGOP00000008804 -----IAC-XXXXXXXXXXXXX--XXXXXXXXXXXXXXX-XX--XXXXXXXXXXX----XXXX--ETSAQMIEENLNCLGHLSTIIHEANEE-QGS----SMM----------------- O_latipes_ENSORLP00000011761 -----VAC-VSNTICGCVFRNR-----TTLQCRHNIPLIGKI--SSKR-----------------ETVGQLLNENQRYLSHLTSLMQDAAQS-MEH----SVMDQ-DWSWTQSGAVKVQS T_nigroviridis_ENSTNIP00000019642 -----IAC-VSTQKCLVGNAVS--HTP------------------NIHSDGSEMTFFFFS-----MSVHQLLEENENYLSQLTSMLQETTKE-TEH----TVVEQ-DWSWTQY------- M_mulatta_ENSMMUP00000010949 -----IAC---SKVRGPVSGSP--DSMNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLLENAIQDTVRE-QDQ----SFTAL-DWSWLQTEEEE-HS H_sapiens_ENSP00000339151 -----IAC---SKVRGPVSGSP--DSMNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLLENAIQDTVRE-QDQ----SFTAL-DWSWLQTEEEE-HS M_musculus_ENSMUSP00000033939 -----IAC---SKVRGPVSGSP--DSMNVSR----LSHPGQL-MSQPSSACDSLP-----ESD--KKSEELVAEAHALCSRLESALQDTVKE-QDR----SFTTL-DWSWLQMEDEE-RC C_familiaris_ENSCAFP00000008270 -----IAC---SKVRGPVSGSP--DSMNASR----LSHSGQL-LAQPSPAPSSLP-----EAI--KKSEELVAEAHTLCTQLENAMQDTIKE-QDQ----SLRSL-DWSWLQTEEEQ-NS A_carolinensis_ENSACAP00000012680 -----IAC---NKVRGPVSGSP--DSMNPSR----LSSPGQL-PLQVTAPQSNAG-----DAG--IKSEELLTESQTLCSQLENVMLDTMKD-QEH----SFMAL-DWSWLKLRAEE-KE R_norvegicus_ENSRNOP00000025851 -----IAC---SKVRGPVSGSP--DSMNVSR----LSHPGHL-MSQPSSACDSLP-----DSD--KKSEELVAEAHALCSRLESALQDTVKQ-QDR----SFTTL-DWSWLQMEDEE-RC G_gallus_ENSGALP00000005924 -----IAC---SKVRGPVSGSP--ESMNMSR----LNSPGQL-LLQVPSGTYALS-----ESV--RKSEELLLESQKLCSQLENVMHDTMKD-QEQ----SFMAL-DWSWLQLHVEE-RS O_anatinus_ENSOANP00000001111 -----IAC---SKVRGPVSGSP--DSMNTSR----LSNSNQL-LSQPPAVPCSLP-----EPI--RKSEDLVVEAQNLCTQLENAMQDTMKE-QDR----SFMAL-DWSWLQIDDEE-RN P_troglodytes_ENSPTRP00000034602 -----IAC---SKVRGPVSGSP--DSMNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLLENAIQDTVRE-QDQ----SFTAL-DWSWLQMEEEE-HS O_latipes_ENSORLP00000003067 -----VAC---SKVRSPVSGSP--DGLRTPSSVPPLLTPRDS-LQQIINPSSD------------KSDESLLEESRTFESRLQSLLHTTIQE-SES----SMEMLREWTWLSGEESDFRC B_taurus_ENSBTAP00000049055 -----IAC---SKVRGPVSGSP--DSMNASR----LSHPCQL-MSQPCTAPDSLP-----EAA--EKSEDLVAEAHTLCTQLENALQDTMKE-QDQ----SLRSL-DWSWLQSEEEE-QQ M_domestica_ENSMODP00000012792 -----IAC---SKVRGPVSGSP--DSMNASR----LSNPSQL-LSQPPTAPYSLP-----DSI--KKSEELVTETQSLCTQLQSMMEDAMKK-QDQ----SFMTL-DWSWLHSEDGE-DE X_tropicalis_ENSXETP00000036619 -----IAC---SKVRGPVSGSP--DSLGTSR----MPGPSQL-LSQPPALSASLA----QEYV--KKSEDLLSESLKLCRQMETSMMGFMKE-QDS----SLMSL-DWSWLSQQEEA-SG P_pygmaeus_ENSPPYP00000020804 -----IAC---SKVRGPVSGSP--DSMNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLLENAIQDTVRE-QHQ----SFTAL-DWSWLQTEEEE-HS O_cuniculus_ENSOCUP00000011297 -----XXX-TQSSARSLVGSSL--EGTVTPQASAWLPPT-SA--QREHPLSCVVT----PQDG--DTFAQMIEENLNCLGHLSTIIREANEE-QGN----SMMNL-DWSWLTG------- G_aculeatus_ENSGACP00000005440 -----VAC---SKVRSPVSGSP--DGLPTPSSVPPLLTPRHS-LQQF--------------------DESLVEESRTFEGRLQSLLHDTIQD-SQS----SMEVLREWTWLHSSQN---- T_guttata_ENSTGUP00000016868 -----IAC-TQSSSRSLVSSSL--EGTASSPAATWLPQS-SSGNAAPHPLSSLAA----PEDG--ENFADMIQENVNYLELFSSILQEVRQE-QNS----MMVS---------------- T_nigroviridis_ENSTNIP00000019003 -----VAC---SKVRSPVSGSS--D-------VSPLLTPTHS-LQQLALITFNNGFGCV------CSDESLVEESRTFESRLQSLLHDTIQE-STS----SMEMLSEWTWLR-------- E_caballus_ENSECAP00000003662 -----IAC---SKVRGPVSGSP--DSMNASR----LSHSGQL-VSQPSTTPDSLP-----ESA--KKSEELVAEAHSLCTQLENAIQDTMKD-QDQ----SLRSL-DWSWLQTEDNE-QH T_rubripes_ENSTRUP00000041917 -----VAC---SKVRSPVSGSS--D----------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006628 -----IAC---SKVRGPVSGSP--DSMNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKXXXXXXXXXXXXXXXXXXXXXXXXX-XXX----XXXAL-DWSWLQTEEEE-HS O_cuniculus_ENSOCUP00000006175 -----IAC---XXXXXXXXXXX--XXXXXXX----XXXXXXX-XXXXXXXXXXXX-----XXX--XXXEDLVAEAHSLCTQLESAMQDTVKE-QDQ----SFMTL-DWSWLQPEEEE-EQ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA -----QGS-TSN--TSNPAVSTYNGNAAIIPDIDRIMGSSSG-----------------------TANGDLPGAPKFVVGGTVTTLQNSLGGEPISKSLLCYGEGPDVESLLTANQSLIM A_gambiae_AGAP009166-PA VDANGQAV-TTNGTLSNGGGTPHGPCIADIDDMVPVFASAKT-----------------------RSIASSNGTPKFLLGGPMTPLPSTVTNGSIEGHHR-EEEGPNVDELIAANETLIM A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ---------NLQMLMSASSTPP--PKLELSAAMDRLAISSGS--PSSDPFDS-------------LRTINAIEEAERINNILVNEM--------------KIDHY--------------- A_aegypti_AAEL005359-PA I----------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009565-PA IST--------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ILKENAKPLSAASLPGPNLNVVQPSIAVPSSWPNSIDNPRSSRQRQLK----QLRQGLIEAKNSLNEVRCEVQTGSEILKKLSSLTANRNCASPETPSRPCVPMRTND------------ D_rerio_ENSDARP00000014302 AVQQPV------------------------------KAEVVDGKKKEE----HMILKMTRLKSEMEAVAWELQKNNNMIESLSVVTPTMPVEKKNPQTNRP------------------- D_rerio_ENSDARP00000074566 AVQQPV------------------------------KAEVVDGKKKEE----HMILKMTRLKSEMEAVAWELQKNNNMIESLSVVTPTMPVEKKNPQTNRP------------------- D_melanogaster_FBpp0080920 VDTKTI-------------------------------------NNNNQLAKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNGSLESS------------------------- D_rerio_ENSDARP00000087779 LIHSFA---SGI---------------------------INKSQNRMLYFMNMMIFAMKKLKEEMEGVVKELAENNLFLERFGSLTVDGGMRTVE----RM------------------- T_nigroviridis_ENSTNIP00000005945 VLPLVS---SGMK------------------------SQAYLSQNTLV----EMTLGMKKLKEEMEGVVKELAENNHFLERFGTLTLDGGLR---------------------------- H_sapiens_ENSP00000356087 LLQDRA--KGAQA---------------------SPPPIAPYPSPTRK----DLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV----------------------------- P_pygmaeus_ENSPPYP00000000308 LLQDRA--KGAQA---------------------SPPPIAPYPSPTRK----DLLLHMQELCEGMKLLASDLLDNNRIIERLNTVPAPPDV----------------------------- G_aculeatus_ENSGACP00000000783 VLPLVS---SGMK------------------------PQAYLSQNTLV----EMTLGMKKLKEEMDEVSKELAENNHFLERFGSLTLDGGLR---------------------------- T_rubripes_ENSTRUP00000005087 LQSNQE------------------------------PQQPGLEPTDKQ----HMVLRMHHLKEEMEILVRELKCNNSIIERHRLMTCPPHL----------------------------- M_mulatta_ENSMMUP00000038190 LLQDRA--KGAQA---------------------SPPPIAPYPSPTPK----DLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAAPDV----------------------------- O_latipes_ENSORLP00000019746 PPHQRG------------------------------EQQQGITPSEKD----QMVSRMHHLREEMELLVRELQCNNTIIERLCSLGVVDSAAAREASPARP------------------- O_cuniculus_ENSOCUP00000010441 MFA-AS----GIK---------------------HTMT---------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005386 MFT-AS---SGIK---------------------HTMTPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- M_mulatta_ENSMMUP00000010063 MFA-AS---SGIK---------------------HTMTPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- P_troglodytes_ENSPTRP00000008798 MFT-AS---SGIK---------------------HTMTPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTVDGGLRNVD----CL------------------- E_caballus_ENSECAP00000018587 MFA-AS---SGMK---------------------HAMTPVYPCSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGALTMDGGLRNVD----CL------------------- B_taurus_ENSBTAP00000046540 LLQERT--QGAQA---------------------SPPLTAPYPSSVLK----DLVLHMQELHGEMKVLASDLQDNNRIIEGLSRIPLAPDI----------------------------- H_sapiens_ENSP00000329967 MFT-AS---SGIK---------------------HTMTPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- C_familiaris_ENSCAFP00000000505 MFA-AS---SGIK---------------------HTMTPIYPCSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- R_norvegicus_ENSRNOP00000009260 MLA-AS---SGIK---------------------HTVAPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- M_musculus_ENSMUSP00000020316 MLA-AS---GGVK---------------------HAMAPIYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- A_carolinensis_ENSACAP00000003243 MLA-AS---GGIK---------------------HAVNPVYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHLLERFGALTMDGGPRNVD----CI------------------- E_caballus_ENSECAP00000000587 LLQDRA--KGAQA---------------------SPPPTAPYPSPALK----DLVLHMQELYEEMKLLAFDLQDNNRIIEGLSRVPSTPGV----------------------------- T_guttata_ENSTGUP00000006693 MFA-AS---NGMK---------------------HTMNTVYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGALTMDGGLRNVD----CM------------------- X_tropicalis_ENSXETP00000015947 MFA-AP---GGIK---------------------SAVNPIYSSPNTLV----EMTLGMRKLKEDMEGVVKELEENNHILERFGALTIDGGFRNVD----CI------------------- M_domestica_ENSMODP00000002458 LWQGRM--KAAQD---------------------SSLPLAAYSRSMPK----DLVLHIQELREEMKLLAFDLQHNNQIIERLSGVPAAPRS----------------------------- B_taurus_ENSBTAP00000023134 MFA-AS---SGIK---------------------HTMTPIYPCSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD----CL------------------- G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 MFA-AS---TGMK---------------------HTMNTVYPSSNTLV----EMTLGMKKLKEEMEGVVKELAENNHILERFGALTADGGLRNVD----CI------------------- R_norvegicus_ENSRNOP00000030127 LLLDRASKQGAEV---------------------SPQPMATHPGPDPK----DLVFHMQELCNDMKLLAFDLQDNNRLIERLHRVPPTPEV----------------------------- X_tropicalis_ENSXETP00000017637 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 LLLDRASEQGAEV---------------------SPQPMAPHPGPDPK----DLVFHMQELCNDMKLLAFDLQDNNRLIERLHRVPSAPDV----------------------------- D_rerio_ENSDARP00000036490 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 RCPGST--EGKAA---------------------RPPRPSPLFKYCYQ----ENSMDMRELQEEMKSVTFDLQHNNSIIESLGRVPPFPFF----------------------------- C_elegans_Y60A3A.12 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T08D2.7 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000020214 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000010492 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000010568 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000024227 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000110117 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000008885 LEEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLALLSLGNQSLPHSSPRPASAKHCRKLIHLLRPTHSM---------------------------- M_musculus_ENSMUSP00000005164 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000012244 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014729 LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIRQVLVSLGASEKLALLSLGNQLLPHSSPRPASAKHCRKLIHLLRPAHSM---------------------------- T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000295709 LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM---------------------------- R_norvegicus_ENSRNOP00000043572 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000022091 LGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM---------------------------- P_pygmaeus_ENSPPYP00000003153 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000006107 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358104 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005279 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001738 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVLVSLRASDKLALLSLGNQ-LPHSSARPASARHCRKLIQLLRPTHDT---------------------------- B_taurus_ENSBTAP00000038069 LGEELLQCQVPQRLLEMACGDPQPNVKEAALVALRSLRQEPCIHQVLVSLGASEKLALLSLGNQLLPHSSPRPASAKHCRKLIHLLRPTHST---------------------------- C_familiaris_ENSCAFP00000017912 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000008449 LGEELLQCQVPQRLLEMACGDPQPNVKEAALIALRSLRQEPCIHQVLVSLGASEKLALLSLGNPSLPHSSPRPASAKHCRKLIHLLRPTHST---------------------------- B_taurus_ENSBTAP00000053464 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000084430 LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPNSSNRPASVRHCRKLIQLLRPTHST---------------------------- R_norvegicus_ENSRNOP00000022839 LGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLRQEPCIHQVLVSLGASEKLTLLSLGHQLLPSSNSRPTSARHCRKLIHLLRPTHST---------------------------- G_gallus_ENSGALP00000014351 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006845 ------------------------------------------------------------------------------------------------------------------------ C_elegans_ZK909.2c ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000001115 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000001970 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000005713 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018211 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 LQSKQT----------------------------------GQQPEIKD----QMVSRMHHLKEEMEMLVRELQCNNSIIESLGTVSPAEALEPNLARPSTL------------------- M_domestica_ENSMODP00000006295 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010874-PA ------------------------------------------------------------------------------------------------------------------------ 1930 =========+=== H_sapiens_ENSP00000359424 ------------- P_troglodytes_ENSPTRP00000055512 ------------- M_mulatta_ENSMMUP00000024306 ------------- C_familiaris_ENSCAFP00000014093 ------------- B_taurus_ENSBTAP00000009985 ------------- P_pygmaeus_ENSPPYP00000002975 ------------- R_norvegicus_ENSRNOP00000034134 ------------- M_musculus_ENSMUSP00000026217 ------------- E_caballus_ENSECAP00000005937 ------------- M_domestica_ENSMODP00000013213 ------------- G_gallus_ENSGALP00000005196 ------------- O_anatinus_ENSOANP00000003934 ------------- T_guttata_ENSTGUP00000004836 ------------- A_carolinensis_ENSACAP00000011973 ------------- X_tropicalis_ENSXETP00000038296 ------------- T_rubripes_ENSTRUP00000022821 KKRNA-------- D_rerio_ENSDARP00000013115 PRL---------- T_nigroviridis_ENSTNIP00000014802 KKR---------- O_latipes_ENSORLP00000016017 KKQNA-------- G_aculeatus_ENSGACP00000005520 KKRNP-------- G_aculeatus_ENSGACP00000008884 NNL---------- T_rubripes_ENSTRUP00000036336 ------------- G_gorilla_ENSGGOP00000008804 ------------- O_latipes_ENSORLP00000011761 QKP---------- T_nigroviridis_ENSTNIP00000019642 ------------- M_mulatta_ENSMMUP00000010949 CLEQA-S------ H_sapiens_ENSP00000339151 CLEQA-S------ M_musculus_ENSMUSP00000033939 SLEQACD------ C_familiaris_ENSCAFP00000008270 -LEQA-S------ A_carolinensis_ENSACAP00000012680 NLEQT-Q------ R_norvegicus_ENSRNOP00000025851 GLEQACD------ G_gallus_ENSGALP00000005924 SPEQTHM------ O_anatinus_ENSOANP00000001111 SLEQTQI------ P_troglodytes_ENSPTRP00000034602 CLEQA-S------ O_latipes_ENSORLP00000003067 SFSHKID------ B_taurus_ENSBTAP00000049055 SLERA-S------ M_domestica_ENSMODP00000012792 GVEQTQI------ X_tropicalis_ENSXETP00000036619 TSPITTT------ P_pygmaeus_ENSPPYP00000020804 CLEQA-S------ O_cuniculus_ENSOCUP00000011297 ------------- G_aculeatus_ENSGACP00000005440 -FSSDLS------ T_guttata_ENSTGUP00000016868 ------------- T_nigroviridis_ENSTNIP00000019003 ------------- E_caballus_ENSECAP00000003662 SLEQA-S------ T_rubripes_ENSTRUP00000041917 ------------- G_gorilla_ENSGGOP00000006628 CLEQA-S------ O_cuniculus_ENSOCUP00000006175 A------------ T_guttata_ENSTGUP00000005662 ------------- A_aegypti_AAEL003245-PA TYGSRIDSAKDVE A_gambiae_AGAP009166-PA T------------ A_aegypti_AAEL010548-PA ------------- D_melanogaster_FBpp0082690 ------------- A_aegypti_AAEL005359-PA ------------- A_gambiae_AGAP009565-PA ------------- A_carolinensis_ENSACAP00000012863 ------------- C_intestinalis_ENSCINP00000011687 ------------- D_rerio_ENSDARP00000014302 ------------- D_rerio_ENSDARP00000074566 ------------- D_melanogaster_FBpp0080920 ------------- D_rerio_ENSDARP00000087779 ------------- T_nigroviridis_ENSTNIP00000005945 ------------- H_sapiens_ENSP00000356087 ------------- P_pygmaeus_ENSPPYP00000000308 ------------- G_aculeatus_ENSGACP00000000783 ------------- T_rubripes_ENSTRUP00000005087 ------------- M_mulatta_ENSMMUP00000038190 ------------- O_latipes_ENSORLP00000019746 ------------- O_cuniculus_ENSOCUP00000010441 ------------- P_pygmaeus_ENSPPYP00000005386 ------------- M_mulatta_ENSMMUP00000010063 ------------- P_troglodytes_ENSPTRP00000008798 ------------- E_caballus_ENSECAP00000018587 ------------- B_taurus_ENSBTAP00000046540 ------------- H_sapiens_ENSP00000329967 ------------- C_familiaris_ENSCAFP00000000505 ------------- R_norvegicus_ENSRNOP00000009260 ------------- M_musculus_ENSMUSP00000020316 ------------- A_carolinensis_ENSACAP00000003243 ------------- E_caballus_ENSECAP00000000587 ------------- T_guttata_ENSTGUP00000006693 ------------- X_tropicalis_ENSXETP00000015947 ------------- M_domestica_ENSMODP00000002458 ------------- B_taurus_ENSBTAP00000023134 ------------- G_gallus_ENSGALP00000021757 ------------- G_gallus_ENSGALP00000015982 ------------- R_norvegicus_ENSRNOP00000030127 ------------- X_tropicalis_ENSXETP00000017637 ------------- M_musculus_ENSMUSP00000054126 ------------- D_rerio_ENSDARP00000036490 ------------- O_anatinus_ENSOANP00000008566 ------------- C_elegans_Y60A3A.12 ------------- C_elegans_T08D2.7 ------------- R_norvegicus_ENSRNOP00000020214 ------------- O_latipes_ENSORLP00000008832 ------------- B_taurus_ENSBTAP00000010492 ------------- T_rubripes_ENSTRUP00000010568 ------------- R_norvegicus_ENSRNOP00000024227 ------------- M_musculus_ENSMUSP00000110117 ------------- M_mulatta_ENSMMUP00000008885 ------------- M_musculus_ENSMUSP00000005164 ------------- T_nigroviridis_ENSTNIP00000012244 ------------- P_pygmaeus_ENSPPYP00000014729 ------------- T_nigroviridis_ENSTNIP00000013350 ------------- H_sapiens_ENSP00000295709 ------------- R_norvegicus_ENSRNOP00000043572 ------------- P_troglodytes_ENSPTRP00000022091 ------------- P_pygmaeus_ENSPPYP00000003153 ------------- M_mulatta_ENSMMUP00000006107 ------------- H_sapiens_ENSP00000358104 ------------- P_troglodytes_ENSPTRP00000005279 ------------- O_cuniculus_ENSOCUP00000001738 ------------- B_taurus_ENSBTAP00000038069 ------------- C_familiaris_ENSCAFP00000017912 ------------- E_caballus_ENSECAP00000008449 ------------- B_taurus_ENSBTAP00000053464 ------------- M_musculus_ENSMUSP00000084430 ------------- R_norvegicus_ENSRNOP00000022839 ------------- G_gallus_ENSGALP00000014351 ------------- T_guttata_ENSTGUP00000006845 ------------- C_elegans_ZK909.2c ------------- M_musculus_ENSMUSP00000001115 ------------- B_taurus_ENSBTAP00000001970 ------------- A_carolinensis_ENSACAP00000005713 ------------- A_aegypti_AAEL007931-PA ------------- G_aculeatus_ENSGACP00000018211 ------------- G_aculeatus_ENSGACP00000000485 ------------- M_domestica_ENSMODP00000006295 ------------- A_gambiae_AGAP010874-PA -------------