10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000357625 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGG--------------------------------------- P_troglodytes_ENSPTRP00000005394 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGG--------------------------------------- G_gorilla_ENSGGOP00000014167 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- M_mulatta_ENSMMUP00000029538 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- C_familiaris_ENSCAFP00000033658 GHCRLSTALSPGAPRGRAPRVKAVLIPEQKQNRPVPGRGRRAPAQRRPSDAMSHSGTPGLQEENLQGSWVELHFSNNGNGS--------------------------------------- P_pygmaeus_ENSPPYP00000003236 ---------------------------------------------------MSQNGAPGMQEESLQGSWVELHFSNNGNGS--------------------------------------- E_caballus_ENSECAP00000015204 ------------------------------------------------------------------GSWVELHFSNNGNGS--------------------------------------- M_domestica_ENSMODP00000024552 ----------------------------------------------------HGQRGSSSLILHAAGSWVELHFSSNGGGP--------------------------------------- R_norvegicus_ENSRNOP00000023477 ---------------------------------------------------MSQSG-----EENLQGSWVELHFS-NGNGS--------------------------------------- M_musculus_ENSMUSP00000101718 ---------------------------------------------------MSQSG-----EENLQGSWVELHFS-NGNGS--------------------------------------- B_taurus_ENSBTAP00000023684 ---------------------------------------------------MQESEKPGPQAESPSGSWVELHFGSNGNGS--------------------------------------- R_norvegicus_ENSRNOP00000016874 ---------------------------------------------------MSQSG-----EENLQGSWVEQHFS-NGNGS--------------------------------------- O_cuniculus_ENSOCUP00000002192 -------------------------------------------------------------------SWVELHFSNNGNGN--------------------------------------- X_tropicalis_ENSXETP00000053966 ---------------------------------------------------MSENEGPNLQDEHLQGSWVELHFSNNGNFP-----------------------------------TTQL G_gallus_ENSGALP00000017040 ------------------------------------------------------------------GSWVELHFSSNGNGN---------------------------------GNSVAA D_rerio_ENSDARP00000096193 ---------------------------------------------------YKNHNKTRMLFGFSSGSWVELHFNNGGGST------------------------------------SKA G_aculeatus_ENSGACP00000012570 ----------------------------------------------------FLKHGTMSSDESLQGSWIELHFSGNGSQS----------------------------------ASLPL O_latipes_ENSORLP00000007433 ----------------------------------VSHLYSLTPSIHPSSNRKAQETIGLPPSLFCSCSWVELHFSGNGSQG----------------------------------TCHRG A_carolinensis_ENSACAP00000007888 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014798 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------G-NGNGKN G_aculeatus_ENSGACP00000024002 --------------------------------------------MSAAADAANVSPADRAGDSGLNGSWVELEMNRGTAGSAQSPSA---------------APGLLPLPQ-VEEEEAMV T_nigroviridis_ENSTNIP00000007933 --------------------------------------------MSEAAN----TTSDNNGDAGLNGSWVELEMNKGAPGSVQSTSTT------------GPAAGLLPLPQ-VDEEEAMV T_rubripes_ENSTRUP00000017630 --------------------------------------------MSEAAN----STTDNNGDAGLNGSWVELEMNRGAAGSVQSTSTT------------GPAAVLLPLPQ-VEEEEAMV T_guttata_ENSTGUP00000004349 ----------------------------------------------------------SFPPPALNSSWVELQMNGNGNSN-------------------------------D-NSNGKN E_caballus_ENSECAP00000004553 ----------------------MSS-----HLVEQPPPLHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN D_rerio_ENSDARP00000038022 --------------------------------------------MSDAA-----APADNNGEPGLNGSWVELEMNRNAASLSSSSASV-----------------PPPLAQVVEEDDGMV A_carolinensis_ENSACAP00000006002 ---------------------------------------HNN------NNN--PPPEGTPAEAGLNSSWVELQMNGNGNGN-------------------------------D-NGNTKN T_rubripes_ENSTRUP00000001438 -------------------------------------------NMSTAA-----APRNNNDEPGLHGSWVELELNGNTGSQDVQAGLLITPAADQINANAGTSHTFQTLQVASEGDEAVA X_tropicalis_ENSXETP00000022422 ----------------------MS---------------ENN------NNN--------GEEAALHGSWVELQMNGNGNNN-------------------------------D---SNRN C_familiaris_ENSCAFP00000034684 ----------------------------WICFEARQNSYQNSPHSHLHMTEFGSAVVNLSYLTCPTGSWVELPMN-SSNGN-------------------------------D-NGNGKN G_aculeatus_ENSGACP00000015037 -------------------------------------------NMSTAA-----AQQNNNEEPGLHGSWVELKLNGNTGNPGVQTSLPETSAADQINANAGMSQTLQTLEDVPESDETLI M_mulatta_ENSMMUP00000032171 ----------------------MSS-----HLVEPPPPLHNN------NNNCEESGQSLPQPAGLNSSWVELPMS-NSNGN-------------------------------D-NGNGKN M_musculus_ENSMUSP00000022634 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQPLPPPAGLNSSWVELPMN-SSNGN-------------------------------E-NGNGKN B_taurus_ENSBTAP00000033770 ----------------------MSS-----HLVEQPPPPHNN------NNNCEEGEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN T_nigroviridis_ENSTNIP00000016323 --------------------------------------------------------MSFQTDDGFQESWVELHFGGTASQS-----------------------------------TSHH M_musculus_ENSMUSP00000099113 ----------------------M-S-----HLVEPPPPLHNN------NNNCEEGEQPLPPPAGLNSSWVELPMN-SSNGN-------------------------------E-NGNGKN O_latipes_ENSORLP00000015175 --------------------------------------------MSTVA-----APENNNEEPGLQGSWVELELNGNTGVQGEPISLSLTPAADQINANSSINQSLQTLE-VAESAESLI O_cuniculus_ENSOCUP00000009082 ----------------------MSS-----HLVEPPPPLHNN------NNNCEDGDQHLPPPTGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN P_pygmaeus_ENSPPYP00000020684 ----------------------MSS-----HLVEPPPPLHNN------NNNCEESDQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN H_sapiens_ENSP00000370003 ----------------------MSS-----HLVEPPPPLHNN------NNNCEENEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN P_troglodytes_ENSPTRP00000034406 ----------------------MSS-----HLVEPPPPLHNN------NNNCEENEQSLPPPAGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN M_domestica_ENSMODP00000027977 ----------------------MSS-----PLVEQPPPLPNN------NNN-NEGEQPLAPPAGLNSSWVELQMNGNGNGN-------------------------------DGNGNGKN D_rerio_ENSDARP00000036535 --------------------------------------------MSTTA----AAQLNNNEEPGLNGSWVELEMNGNTQHQSPSLPSLLG------NGNQGEPQTSQALEAVQEEEEVLT T_rubripes_ENSTRUP00000015895 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011996 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000000309 ----------------------MSS-----P---QEPPHHNN------NNN--PPAEGTQTEPGLNSSWVELQMNGNGNSN-------------------------------D-NGNGKN R_norvegicus_ENSRNOP00000055295 ----------------------MSHLVKLLPLNNNNNNNNNNDNDNNNDNNCEEGEQPLPLPSGLNSCWEELPMN-SSNGN-------------------------------D-NENSKN G_aculeatus_ENSGACP00000021335 ----------------------------------------------------MSLPGPQAPEDGLHGSWVELEELITAVSR----------------------------------RESPA T_rubripes_ENSTRUP00000046089 ----------------------------------------------------MSLSGSHTPEDGLYGSWVELEELIAAVSR----------------------------------RESLT O_latipes_ENSORLP00000006124 ----------------------------------------------------MSLSGSQTPEDGLYGSWVELEELMAAVSR----------------------------------RESLT T_nigroviridis_ENSTNIP00000017287 ----------------------------------------------------MSVSGSHTPEDGLYGSWVELEELIAAVSR----------------------------------RESLT R_norvegicus_ENSRNOP00000049965 ----------------------LGM-----WLQSPPPPHHHHHHHHHRNNNCKEGEQPLPPPSGLNSSWVELPMN-SSNGN-------------------------------D-NGNGKN D_rerio_ENSDARP00000037307 ----------------------------------------------------MALSGSQSPDDALHGSWVELEGLVASANQ----------------------------------TEGES O_anatinus_ENSOANP00000025117 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015347 --------------------------------------------MSDAAN--TASTDNNGGDSGLNGSWVELEMNRAHQAQASLTG--------------GLAPGLLPLPQ-VEEEEAIV D_rerio_ENSDARP00000032168 ----------------------------------------------------MSTQKVIPKEESLHDSWVELHFDSSSEHS--------------------------------------- O_anatinus_ENSOANP00000019225 -------------------------------------------------------------------SWVELQMNDNGNGN-------------------------------D-NGNGKS R_norvegicus_ENSRNOP00000041876 -------------------------------------TMSNLVEQSLPLHNNCEEGYPLPPPAGLNGSLVELLMNSSKGND---------------------------------SGNGKN A_aegypti_AAEL006711-PA ----------------------------------------MFKSINLTSEPNKMSATPRSSEDLLGESWIELSSSTNTCPK--------------------------------------- A_gambiae_AGAP001411-PA ---------------------------------------------------------GGSSNNFVPTGTTMLAGAVGT--K--------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000357625 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRASETDTHSI-GEKNSSQSEE---D----DIERR---KEVESILKKNSDWIWD P_troglodytes_ENSPTRP00000005394 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRASETDTHSI-GEKNSSQSEE---D----DIERR---KEVESILKKNSDWIWD G_gorilla_ENSGGOP00000014167 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRASETDTHSI-GEKNSSQSEE---D----DIERR---KEVESILKKNSDWIWD M_mulatta_ENSMMUP00000029538 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRASETDTHSI-GEKNSSQSEE---D----DIERR---KEVESILKKNSDWIWD C_familiaris_ENSCAFP00000033658 ----SVPASASIYNGD-LEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTTRASEVDTHSI-GEKNSSQSEE---D----YIERR---KEVESILKKNSDWIWD P_pygmaeus_ENSPPYP00000003236 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQT--DTNRASETDTHSI-GE-NSSQSEE---D----DIERR---KEVESILKKNSDWIWD E_caballus_ENSECAP00000015204 ----SVPASVSIYNGE-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRAFETDTHSI-GEKNSSQSEE---D----YIERR---KEVESILKKNSDWIWD M_domestica_ENSMODP00000024552 --SPVAPASISAYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTARMSEADTHSI-GEKNSSQSEE---D----YMERR---KEVESILKKNSDWIWD R_norvegicus_ENSRNOP00000023477 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRA-EIDTHSF-GEKNSTLSEE---D----YIERR---REVESILKKNSDWIWD M_musculus_ENSMUSP00000101718 ----SVPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRA-EIDSHSF-GEKNSTLSEE---D----YIERR---REVESILKKNSDWIWD B_taurus_ENSBTAP00000023684 ----SVPDSVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRASETDTHSL-GEKNSSQSEE---D----YMERR---KEVESILKKNSDWIWD R_norvegicus_ENSRNOP00000016874 ----SIPASVSIYNGD-MEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTNRA-EIDTHSF-GEKNSTLSEE---D----YIERR---REVESILKKNSDWIWD O_cuniculus_ENSOCUP00000002192 ----SVPASVSIYNGD-LEKILLDAQH-ESGRSS---SK-SSHCD----------SPPRSQTPQDTTRASETDTHST-GEKTSSQSEE---D----FIERR---KEVESILKKNSDWIWD X_tropicalis_ENSXETP00000053966 MGQDQGPASISIHNGD-MEKILLDAQH-ESGRSS---SRESSHCD----------SPPRSQTP-SIQRCSESDTSGS-KEKSSSQSEE---D----YIERR---KELENLLKKNSDWIWD G_gallus_ENSGALP00000017040 TSQEQVPASISIHNGD-MEKILLDAQH-ESGRSS---SRESSHCD----------SPPRSQTPLDSHRALEIESHSS-GEKNSFQSEE---D----FLERR---REVERLLKKNADWIWD D_rerio_ENSDARP00000096193 ATDEQ--SASTAPSGD-LEKMLLDAQH-ESGRSS---SRGSLPCD----------SPPRSQTPLHLCRGSE--VHSS-GEKNSSQSEE---D----YLERR---KEVEILMKKNADWIWD G_aculeatus_ENSGACP00000012570 GGQEQIP--TGVPQGD-VEEMLLDAQH-ESGRNS---SKGSSQCN----------SPLRAQTPLLVWRG---------SEANSSQSDE---D----FQERR---REVENMMKKNADWIWD O_latipes_ENSORLP00000007433 GQEEQIS--TSSQEGDAVERMLLEAQH-ESGRSS---SRGSSHCN----------SPLRSQTPLLVWRG---------SEGNSSQSDE---D----FQERK---REVENLMKKNADWIWD A_carolinensis_ENSACAP00000007888 -------------------------------------------------------SPPRSQTPQDIHRTSEVESRGS-GEKNSFQSEE---D----FLERR---KEIERLLKKNSDWMWD R_norvegicus_ENSRNOP00000014798 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVDGE---KEVEAL-KKSADWVSD G_aculeatus_ENSGACP00000024002 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCD----------SPPRPHSP-QDDGQIIFDVDLSGRRD--SLSEE---D----GLDKE---RDMDIL-MKDADWVAD T_nigroviridis_ENSTNIP00000007933 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCD----------SPPRPHSP-QDEGQLIFNVDVAGRRD--SQSEE---E----VLDKE---RDMDIL-MKDSDWVAD T_rubripes_ENSTRUP00000017630 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCD----------SPPRPHSP-QDEGQLIFHVDVAGRRD--SQSEE---E----VVDKE---RDMDIL-MKDADWVAD T_guttata_ENSTGUP00000004349 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QDDGQITFDVEMHTSKDNTSQSEE---E----AVEGE---KELEVM-KKSADWVSD E_caballus_ENSECAP00000004553 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRASSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KDVDAL-KKSVDWVSN D_rerio_ENSDARP00000038022 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCD----------SPPRPHSP-QDEGQIIFDVD--TRRD----SQE---E----VMEKI---RDDDIL-MKDSDRMAD A_carolinensis_ENSACAP00000006002 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSKDNSSQSEE---E----PAEGE---KEVDVL-KKSADWVSD T_rubripes_ENSTRUP00000001438 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SSSSSSCD----------SPRRPQSPDQDEGQITFDVEMCSPRH--SQSGG---D----SPEPS---REDEAPLNKEADWVAD X_tropicalis_ENSXETP00000022422 GGLEHVPSSSSIHDGD-MEKILLDAQH-ESGQSS---SRSSSQCD----------SP----SP--EDGQITFDVEMHTSKD-SLQSEE---E----APEEE---KEVDAL-KKSADWVSD C_familiaris_ENSCAFP00000034684 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRASSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----AAEGE---KEVDAL-KKSVDWVSD G_aculeatus_ENSGACP00000015037 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SQSSSSCN----------SPHRPPSPDQDEGQITFDVEMPSPRD--SQSED---D----SAEKY---REEDILMNKEVDWVAD M_mulatta_ENSMMUP00000032171 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD M_musculus_ENSMUSP00000022634 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD B_taurus_ENSBTAP00000033770 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSKDHSSQSEE---E----VAEGE---KEVDAL-KKSVDWVSD T_nigroviridis_ENSTNIP00000016323 GSQEQIP--TTAQEGD-VEKLLLEAQR-ESGRTS---SRGSSQSN----------SPLRARTPLLLWRG---------SDGNSSQSDE---D----FQERR---CEVENLIKKNADWIWD M_musculus_ENSMUSP00000099113 GGLEHVPSSSSIRNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD O_latipes_ENSORLP00000015175 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SPSSSSCD----------SPHRPPSPERDDEQITFDVEMSSLRG--SQSEE---D----ITEKE---REDDILMNREVDWVTD O_cuniculus_ENSOCUP00000009082 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD P_pygmaeus_ENSPPYP00000020684 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQITFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD H_sapiens_ENSP00000370003 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD P_troglodytes_ENSPTRP00000034406 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVEMHTSRDHSSQSEE---E----VVEGE---KEVEAL-KKSADWVSD M_domestica_ENSMODP00000027977 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQIMFDVDMHTSRDHSSQSEE---E----AAEGE---KEVEAL-QKSVDWVSD D_rerio_ENSDARP00000036535 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SPSSSSCN----------SPPRPHSPDQDEGQIMFDVEMPSERD--CQSED---D----SMEKD---KEDDILMNKGESWVAD T_rubripes_ENSTRUP00000015895 -------------------------------------------------------------------------------------SDE---D----FQERR---CEVENLMKRNADWIWD T_guttata_ENSTGUP00000011996 ---------------------------------------------------------------------------------------E---D----FLERR---REVERLLRKNADWIWD G_gallus_ENSGALP00000000309 GGLEHVPSSSSIHNGD-MEKILLDAQH-ESGQSS---SRGSSHCD----------SP----SP-QEDGQITFDVEMHTSKDSSSQSEE---E----AVEGE---KELEVL-KKSADWVSD R_norvegicus_ENSRNOP00000055295 GGLEH-PCSASIHSED-MEKILLDTWH-ELGQSS---SRESSHCD----------SP----SA-QEDG-IMFAVEMHTSRDQSYQSEE---------GEGE---KEVEAL-KKIADWVSN G_aculeatus_ENSGACP00000021335 GSQE---SISSALQGE-LERILLEAQL-ECERS----------KD----------SPTREGTPQSTG-----------SPRPTSDQDS---D----CITIQ---QEEAER-RVDTDWVWD T_rubripes_ENSTRUP00000046089 GPED---SITSTLQGE-LERILLEAQV-ECERN----------RD----------SPPQAGTPQSTG-----------SQRPASDQDS---D----CVPI----QEEADR-RGDADWVWD O_latipes_ENSORLP00000006124 GPQD---SISSALQGE-LERILLEAQL-ECERN----------KD----------SPPQVATPQSTS-----------SPKSTSEHDS---D----CVPIQ---NEEAER-RADTEWVWD T_nigroviridis_ENSTNIP00000017287 GPED---SISSSLQGE-LERILLEAQL-ECERS----------RE----------SPPQAGTPQSTG-----------SQRPASDQDS---D----CVPIQDVIQEEADR-RGDTDWVWD R_norvegicus_ENSRNOP00000049965 GGLEHVSSSSSIHNGD-MEKILLDTQR-ESGQSS---SRGSSHCD----------SP----SR-QEDRQMTFDVEMHSGRDRSSQS-----E----AVEGE---KEVEAL-KKSAEWVSD D_rerio_ENSDARP00000037307 GAQG---TTASVLQGE-LERILLEAQL-ECERS--------AQTD----------SPPQVVTPRTSG-----------SPKPGSEGSSSSTD----CVTIQ---SDENDR-RVSAEWVWD O_anatinus_ENSOANP00000025117 ----------------------------------------SSSSG----------SPPRSQTPQDVNRASETDTHSS-GEKNSSQVRA---DPPAAALRAR---YGLGKYDRTKARMKLR O_latipes_ENSORLP00000015347 GGLEHVPSSSSIHNGD-MEKILLDAQH-ES-------SRSNSSCD----------SPPRPHSP-QDEGQIIFDVDMAARRD--SQSEE---E----VSDKE---RDMDIL-MKDADWVAD D_rerio_ENSDARP00000032168 ---EDTPALSDIM--D-LEKMLLEAQR-ESSSS----SRTSSHCSSGFCDLFPPPSPRRVQTPPLINTAV--------FNTHTIAQGE---V----VLESK---QEAEAVAR-----ISD O_anatinus_ENSOANP00000019225 GGLEHVPSTSYNHNRY-MQNIHLDAAP-EPININ---VPYPPNID----------SP----SP-QEDGQIMFDVEMHPSRDPSSQSEE---E----TIEGE---KDVEVL-KKSVDWVSD R_norvegicus_ENSRNOP00000041876 WGLEHVPSWPSSHSGD-ME------------QSS---LRGSSHSD----------CS----SP-QEDGQVMFNVEMLTSKDHNSQLEE---E----VVEGE---KEVETL-KKSADWVSD A_aegypti_AAEL006711-PA -SPDRTTPLPFTSVEE-YLRLLREAQR-ESKESSRVASLTSSRRD----------SPRG--SPKSPPNSP--NTELATTEEELRGVYI---N----YLNRE---GAATSA-QKDTDWVWE A_gambiae_AGAP001411-PA -SPDRTTPLAFASVEE-YIRLLREAQRDESKESSRVASLTSTRKN----------SPRG--SPKSPPNSP--NTELAATEEDLRNVYI---N----YVNKD---G---DI-VKDTDWVWD 250 260 270 280 290 300 310 320 330 340 350 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+= H_sapiens_ENSP00000357625 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- P_troglodytes_ENSPTRP00000005394 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- G_gorilla_ENSGGOP00000014167 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- M_mulatta_ENSMMUP00000029538 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- C_familiaris_ENSCAFP00000033658 WSSRPENIPP-KEL-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- P_pygmaeus_ENSPPYP00000003236 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- E_caballus_ENSECAP00000015204 WSSRPENVPP-KEF-LFRH-PKR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- M_domestica_ENSMODP00000024552 WSSRPENVPP-KEF-LFKH-PKR---------SATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---FL-AIGLGIYIGRRLTSSAS----------T--F-------- R_norvegicus_ENSRNOP00000023477 WSSRPENVPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- M_musculus_ENSMUSP00000101718 WSSRPENIPP-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- B_taurus_ENSBTAP00000023684 WSSRPENVPPAKEFLLFKH-PKR---------TPTLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- R_norvegicus_ENSRNOP00000016874 WSSRPENVPH-KEF-LFKH-PKR---------TATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTSTS----------T--F-------- O_cuniculus_ENSOCUP00000002192 WSSRPENVPP-KQL-LFRH-PRR---------AAALSMRNTSVMRKGGVFSADVLKVFLPSLLLSH---LL-AIGL----------------------------------- X_tropicalis_ENSXETP00000053966 WSSRPENIPP-KEF-LFKH-PKR---------SSALSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGVYIGRRLTTSTG----------T--F-------- G_gallus_ENSGALP00000017040 WSSRPENIPP-KEF-LFKH-PRR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SSSF-------- D_rerio_ENSDARP00000096193 WSSRPENLPP-KEF-LLRH-PKR---------SSTLSMRNTSVMKKGGIFSAEFLKVFLPSLVLSH---IL-AVGLGVYIGRRFTASGT-------------F-------- G_aculeatus_ENSGACP00000012570 WSSRPENNPP-KEF-LLKN-PKR---------STSLSIRNTSVMKKGGVLSADFLKLFLPSLIISH---IL-AVGLGIYIGKRLTSHNT-------------Y-------- O_latipes_ENSORLP00000007433 WSSRPENSPP-KEF-LLKR-PKR---------ASSLSIRNSSVMKKGGILSADFLKLFLPSLIISH---IL-AVGLGIYIGKRLTSHHT-------------Y-------- A_carolinensis_ENSACAP00000007888 WSSRPENIPP-KEF-LFKH-PKR---------TSALSMRNTSMMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SS---------- R_norvegicus_ENSRNOP00000014798 WSSRPENIPP-KEF-LFRH-PKR---------AASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- G_aculeatus_ENSGACP00000024002 WSSRPENIPP-KEF-HFRH-PRR---------SVTLSMRKTGAMKKGGIFSADFLKVFIPSLLLSH---IL-AVGLGVYIGKRLSAPAA----------SS-F-------- T_nigroviridis_ENSTNIP00000007933 WSSRPENIPP-KEF-HFRH-PRR---------SVMLSMRKTGAMKKGGIFSAEFLKVFIPSLLLSH---IL-ALGLGVYIGKRLTTPPA----------SS-F-------- T_rubripes_ENSTRUP00000017630 WSSRPENIPP-KEF-NFRH-PRR---------SVMLSMRKTGAMKKGGIFSAEFLKVFIPSLVLSH---IL-ALGLGVYIGKRLTTPPA----------SS-F-------- T_guttata_ENSTGUP00000004349 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTTPSA----------ST-Y-------- E_caballus_ENSECAP00000004553 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- D_rerio_ENSDARP00000038022 WSSRPENIPP-KEF-HFRH-PRR---------SVTLSMRKTGAMKKGGIFSAEFLKVFIPSLLLSH---IL-VLGLGVYIGKRLTTPPA----------SS-I-------- A_carolinensis_ENSACAP00000006002 WSSRPENIPP-KEF-HFRH-PKR---------AVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTTPSA----------ST-Y-------- T_rubripes_ENSTRUP00000001438 WSSRPENVPP-KEF-HFRH-PRR---------SVSLSMRRSGVMKKGGIFSADFLKVLIPSLLISH---LL-ALGLGVYIGKRIAAAPT----------SS-Y-------- X_tropicalis_ENSXETP00000022422 WSSRPENIPP-KEF-HFHH-PKR---------SVSLSMRKTGAMKKGGVFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLTLSSA----------SS-Y-------- C_familiaris_ENSCAFP00000034684 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- G_aculeatus_ENSGACP00000015037 WSSRPENVPP-KEF-HFRH-PRR---------SVSLSMRKTGVMKKGGIFSTEFLKVFIPSLLISH---IL-ALGLGVYIGKRIATAST----------SS-Y-------- M_mulatta_ENSMMUP00000032171 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPCQHLLRERKSPWKC-V-------- M_musculus_ENSMUSP00000022634 WSSRPENIPP-KEF-HFRH-PKR---------AASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- B_taurus_ENSBTAP00000033770 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- T_nigroviridis_ENSTNIP00000016323 WSSRPENNPP-KEF-LLKY-PKR---------STPLSIRNTSVMKKGGVLSADFLKLFLPSLILSH---IL-AVGLG----------------------DLHR-------- M_musculus_ENSMUSP00000099113 WSSRPENIPP-KEF-HFRH-PKR---------AASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- O_latipes_ENSORLP00000015175 WSSRPENVPP-KEF-HFRH-PRR---------SVSLSMRKSGVMKRGGIFSSEFLKVFIPSLLISH---IL-ALGIGVYIGKRIATAST----------SS-Y-------- O_cuniculus_ENSOCUP00000009082 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSAPCQHLLRGAK-PWTR-V-------- P_pygmaeus_ENSPPYP00000020684 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- H_sapiens_ENSP00000370003 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- P_troglodytes_ENSPTRP00000034406 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSH---VL-ALGLGIYIGKRLSTPSA----------ST-Y-------- M_domestica_ENSMODP00000027977 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFISH---VL-ALGLGIYIGKRLSSPSA----------ST-YGRGEPWTC D_rerio_ENSDARP00000036535 WSSRPENVPP-KEF-HFRH-PKRSG-------SVSLSMRKSGAMKKGGVFSAEFLKVFMPSLLLTH---IL-ALGIGVYIGKRLSTPPS----------ST-F-------- T_rubripes_ENSTRUP00000015895 WSSRPENNPP-KEF-LLKH-PKR---------ATSLSIRNTSVMKKGGVLSADFLKLFLPSLIVSH---IL-AIGLGIFIGRRLTS------------------------- T_guttata_ENSTGUP00000011996 WSSRPENIPP-KEF-LFKH-PRR---------TATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTTTAS----------SSTF-------- G_gallus_ENSGALP00000000309 WSSRPENIPP-KEF-HFRH-PKR---------SVSLSMRKSGAMKKGGIFSAEFLGFHSISVHIS-----C-FGGLGIYIGKRLTTPSA----------ST-Y-------- R_norvegicus_ENSRNOP00000055295 CSSRPENIPC-KEF-HFRH-PKH---------AMFLSMRESGAMKKRGIFSAEFLKVFILSLFFSH---VLAALGLGIYIGKQLSTHSA----------ST-Y-------- G_aculeatus_ENSGACP00000021335 WSSRPENMPP-KEF-VFQH-PKQ---------QSSLSVRKTEVMKR-GIFSSDVFLILVPSLLASH---LL-TLGVGIYIGKRLAASTT----------ST-L-------- T_rubripes_ENSTRUP00000046089 WSSRPENIPP-KEF-VFQH-PKQ---------QRSLSIRKTEVMKR-GLFSSDVLLVLGPSLLASH---LL-TLGVGIYIGKRLAASTS----------ST-L-------- O_latipes_ENSORLP00000006124 WSSRPENMPP-KEF-VFQH-PKQ---------QSSLSVRKTEVMKR-GIFSSDVLLILVPSLLASH---LL-TLGVGIYIGKRLAASTT----------ST-L-------- T_nigroviridis_ENSTNIP00000017287 WSSRPENIPP-KEF-VFQH-PKQ---------QSSLSIRKTEVMKR-GLFSSDVLLVLGPSLLASH---LL-TLGVGIYIGKRLAASST----------ST-L-------- R_norvegicus_ENSRNOP00000049965 WSSRPENIPP-KEF-HFRH-PKR---------AVSLSMRKSGATNKGDIFSVVFLKVFTPSLFLSH---LL-LLGLGIYIKMTEHTFCQHLLRETRAPGNT-C-------- D_rerio_ENSDARP00000037307 WSSRPENLPP-KEF-VFHH-PKQ---------SGSLSVRKTEVMKR-GLFSSDVLLILLPSLLASH---AL-TLGLGIYIGKRLASSST----------ST-L-------- O_anatinus_ENSOANP00000025117 WCGLAVR----GEF-LFRH-PRRP--------AAALSMRNTSVMKKGGIFSAEFLKVFLPSLLLSH---LL-AIGLGIYIGRRLTPSTS----------S--Y-------- O_latipes_ENSORLP00000015347 WSSRPENIPP-NLF-EQEK-KER---------VLSLSMQQLLIASFSVLSSCQ-----TPQLLCKHSFNIF-LSPLSVYIGKRLTTPPT----------SS-F-------- D_rerio_ENSDARP00000032168 WSSRPENIPP-TAF-IIKR-PKR---------N---RICNTNTDKDDKEIDRDLLKLLLPSLVLTH---IL-MLGLGICIGRRLSTQCS----------TI---------- O_anatinus_ENSOANP00000019225 WSSRPENIPP-NLW-YLEAFPGRA--------SPPLGNDFSRALKEGGHKQGVSCKVMMVVILEEQ---IL-QTGFYIYIGKRLSTPSA----------ST-Y-------- R_norvegicus_ENSRNOP00000041876 WSSRP-NIPP-KKF-HFRH-PKR---------NVSLSMRKSGTMKKGVIVFAKFL-LHPFSLPFSQ---V--DFGAGLN-GKEQSTPSA----------ST-Y-------- A_aegypti_AAEL006711-PA WSSRPDQLPP-KDW-KFEH-PKQDV----RRMQQGYSMRLTRV-GKNSLFSREVLYSLVLTNVLSL---LL-GAGIGAWLHKRGLLFTR----------ISIE-------- A_gambiae_AGAP001411-PA WSSRPDQQPP-KDW-KFEH-PNQTQEERNKPIHAGYSIRQVRV-GKNSLFSREFLYSIVLTNVLSL---LL-GAGIGAWLQKRGLLLTR----------VSIE--------