10        20        30        40        50        60        70        80        90       100       110       120
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000355231                 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE
P_troglodytes_ENSPTRP00000046569          MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE
M_mulatta_ENSMMUP00000034400              MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE
M_musculus_ENSMUSP00000040094             MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------EANSGEE
C_familiaris_ENSCAFP00000021764           MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQVK---------------------PGETQEE--------------------------------EANSGEE
B_taurus_ENSBTAP00000026531               MEGSKTS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQLK---------------------PGETQEE--------------------------------EANSGEE
R_norvegicus_ENSRNOP00000027868           MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGESQEE--------------------------------EANSGEE
E_caballus_ENSECAP00000016069             MEGSKTS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQVK---------------------PGETQEE--------------------------------EANSGEE
M_domestica_ENSMODP00000018835            MEGSKSS-SSTMQVSFVCQRCSQPLKLDTSFKILDQVTIRELTAPLLTTAQTK---------------------PGETQEE--------------------------------ETNSGEE
P_pygmaeus_ENSPPYP00000009414             MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE
G_gallus_ENSGALP00000004697               MEGGRAP-ACTTQVSFVCQRCSQPLKLDTSFKILDRLTIQELTAPLLTAAPAR---------------------PGDAQEE---------------------------------SALSEE
A_carolinensis_ENSACAP00000013592         MDGSKSP-ACTMQVSFVCQRCSQPLKLDTSFKVLDKVTIQELTAPLLTTTPAK---------------------LGDAQEE--------------------------------ETTLTEE
X_tropicalis_ENSXETP00000027611           METSK---SSTMQVSFVCQRCSQPLKLDTSFKILDKVTMQELTAPLVTTAAVK---------------------PGDIQEV--------------------------------DSNI-EE
T_guttata_ENSTGUP00000002874              ----------------------QSIKLDTSLKVLGHLTIQEVPAPLGSAAPAR---------------------PGDPHEE--------------------------------ESALSEE
G_aculeatus_ENSGACP00000008498            MEGSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTIQDLIAPLVTVTPSK---------------------QADRNVG--------------------------------ET-APEE
G_gorilla_ENSGGOP00000001565              --------------------------------------------PLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE
T_nigroviridis_ENSTNIP00000014523         MEVSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTVQELTAPLVTVTPSR---------------------QAESSAG--------------------------------ET-APEE
T_rubripes_ENSTRUP00000034988             MEVSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTVHELTAPLVTVTPSK---------------------QAESSEG--------------------------------ET-APEE
O_cuniculus_ENSOCUP00000013727            VEGSKMP-TSTIQVSFVC-RCSQPLKLDXXXXXXXXXXXXXXXXPLLATAQVK---------------------PGDPQEE--------------------------------EANSGEE
O_latipes_ENSORLP00000005780              -----------------------------------------------------------------------------------------------------------------------E
O_anatinus_ENSOANP00000019267             -------------------------------------------APLLSAAQAK---------------------PTEAHEE--------------------------------EPRAGEE
M_mulatta_ENSMMUP00000002276              ---AGVSPSAMTSIRFLCQRCHQALRLSCSSESGSL-----PAAAAPTSGQAG---------------------PGDTPEP--------------------------------GATTSEV
A_aegypti_AAEL010427-PA                   ------MNDAKVSVGFSCQRCLQPIHIDDSFAALGEHTLAELALPINSHMEVD-------------------------------------------------------------------
P_troglodytes_ENSPTRP00000056655          MRGSGTEGGSMSSIRFLCQRCHQALKLSCSSESRSL-----PATPAPTSGQAE---------------------PGDTREP--------------------------------GVTTREV
P_pygmaeus_ENSPPYP00000000063             MRGSGTEGGSMSSIRFLCQRCHQALKLSCSSESGSL-----PAAPAPTSGQAE---------------------PGDTREP--------------------------------GATTREV
A_gambiae_AGAP003858-PA                   ------MNDAKVSVSFSCQRCMQPIHVDDTFASLGEHTLAELALPINSHLEVD-------------------------------------------------------------------
C_intestinalis_ENSCINP00000019537         --------MTDESICFMCARCKQVIKLDRSFDSIDKQTLQELTSSSRTSTPSEETVAKIDDESQQQLQASSSSDENPPQEQ--------------------------------EVSSSGS
E_caballus_ENSECAP00000015556             --HGESQPSAMSSIHFMCWRCDQPLKLNQSTETPGLDATQASAASALASAEGA---------------------PRETQEG--------------------------------GPTSREE
D_melanogaster_FBpp0083975                -----MSEAEKQAVSFACQRCLQPIVLDEQLEKISVHAMAELSLPIYGDNGNT-------------------------------------------------------------------
O_cuniculus_ENSOCUP00000015004            -PKVKVKTSAMSPI-FICQRCSQPLKLSEPLEML-------------ASTQGE---------------------QGESQET--------------------------------GTSSEKM
G_gorilla_ENSGGOP00000007989              MRGSGTEGGXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXX---------------------XXXXXXX--------------------------------XXXXXXX
C_familiaris_ENSCAFP00000023183           -IRVRAEAFTMSSIRFICQGCRQPMRLSQSTGTLGLETTQRPAASTFTSAQQE---------------------PRETLVR--------------------------------GPTSKVE
R_norvegicus_ENSRNOP00000054742           ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YPL120W                      ---------------MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATN-----ENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANIT
C_elegans_T19E7.3.1                       ---------MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALT--------------------------------------------------------------------

                                                  130       140       150       160       170       180       190       200       210       220       230       240
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000355231                 PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
P_troglodytes_ENSPTRP00000046569          PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
M_mulatta_ENSMMUP00000034400              PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
M_musculus_ENSMUSP00000040094             PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
C_familiaris_ENSCAFP00000021764           PFLET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
B_taurus_ENSBTAP00000026531               PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
R_norvegicus_ENSRNOP00000027868           PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
E_caballus_ENSECAP00000016069             PFIET-CQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
M_domestica_ENSMODP00000018835            PFAET-RQDG-VSRRYIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKASLPIEGVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
P_pygmaeus_ENSPPYP00000009414             PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
G_gallus_ENSGALP00000004697               AFTEG-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
A_carolinensis_ENSACAP00000013592         IFVEN-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------ASCDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
X_tropicalis_ENSXETP00000027611           TFAEN-RTDG-VSRRLIPPARMM--STESATSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
T_guttata_ENSTGUP00000002874              AFVEH-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAI-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
G_aculeatus_ENSGACP00000008498            TFVEN-KQDG-VSRKYIPPARVM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL
G_gorilla_ENSGGOP00000001565              TFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL
T_nigroviridis_ENSTNIP00000014523         AFVEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL
T_rubripes_ENSTRUP00000034988             AFVEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-EASDCG----------NMEHLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL
O_cuniculus_ENSOCUP00000013727            AFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLHVTENECQNYKRCL
O_latipes_ENSORLP00000005780              TFEEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-DASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL
O_anatinus_ENSOANP00000019267             AFTET-RQDG-VSRRFIPPARRD--SSLATSAQLQAGARAGQRN----------PVLPLSSALL-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL
M_mulatta_ENSMMUP00000002276              TDAEE-PQDG-ASSRPLPGDGSV--SKDQANVFTLLG-ELG-------------AMQTLSSIQK-------AAGDIFDIVSGQEDVDHPLCEECTDSLLEQLDIQLALTEAESQNYQRCL
A_aegypti_AAEL010427-PA                   ---IE-SQSA-SMDHFVPPFRFAECSGTDTNGFMLLS-DGP-------------DRDLLSQNLR-------VKAELFDTLSNNSEIDHPLCDECTDTLLELMDKQLKMAEDEWNDYNNYL
P_troglodytes_ENSPTRP00000056655          TDAEE-QQDG-ASSRPLPGDGSV--SKDHANIFTLLG-ELG-------------AMHMLSSIQK-------AAGDIFDMVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCL
P_pygmaeus_ENSPPYP00000000063             TDAGE-QQDG-ASSRSLPGDGSV--SKDHANIFTLLG-ELG-------------AMHMLGSIQK-------AAGDIFDIVSGQEVVDHPLCEECTDSLLEHLDIQLALTEAESQNYQRCL
A_gambiae_AGAP003858-PA                   ---LE-SQSV-SFDHFVPPFRVTD-STNDTNGFMLLS-DGQ-------------NKESLGHSLR-------VKAELFDALSNNSEIDHPLCDECTDTLLELMDKQLKIAEDEWNDYNNYL
C_intestinalis_ENSCINP00000019537         DNPND-VEDS-IYSQNAASSGNE--VHESTNSFTFIG-DT--------------SMENLSHKMK-------VIVRLFDLMSDNSDLEHPLCEECTEALLGELNKELKSTETEATLYKNYL
E_caballus_ENSECAP00000015556             TDSDE-LQDG-ASCRTLPGDGRM--SGDSSNYFILLG-KLS-------------SVRTLNSIQK-------AARDIFDILSSEKAVNQPLCEDCTDNLLLQLDSQLVLTASESENYQRFL
D_melanogaster_FBpp0083975                ---LD-PQDASSFDHFVPPYRLT--DSINGTGFMLVS-DGR-------------DNKKMSAAFK-------LKAELFDCLSSNSEIDHPLCEECADSMLEIMDRELRIAEDEWDVYKAYL
O_cuniculus_ENSOCUP00000015004            RGSEK-LQVG-ASGGALPEDSNT---SEDSGGFTLLG-DVC-------------SVGTLSSLQE-------ATVQIFDILSGQKDVEHPLCEECTDNLLEQLDSQLTLVELDTQNYKRCL
G_gorilla_ENSGGOP00000007989              XXXXX-XXXX-XXXXXXXXXXXX--XXXXXXXXXXXX-XXX-------------XMHMLSSIQK-------AAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCL
C_familiaris_ENSCAFP00000023183           IDTEK-LPD--ASCSTLPGDGKM--FGDSPKNFILLG-KFD-------------SARTLSNIQN-------TTRDIFDILTGEKYVDHPLCEDCTDKLLEVLDTQLIIVDSENEHYKYWR
R_norvegicus_ENSRNOP00000054742           -------------------------------TFTLLG-ESV-------------SVRTLHTVQN-------TTIEIFEILSEQKVVDHPLCVDCTDNLLVQLDDQLTLVASDNQSYQGFL
S_cerevisiae_YPL120W                      SNSREDQRYGNANGNDNKKANSD--TSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVN-------AMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFL
C_elegans_T19E7.3.1                       --------------------------GHSRNLMKLIS-------------------------------------------DAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYI

                                                  250       260       270       280       290       300       310       320       330       340       350       360
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000355231                 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATF
P_troglodytes_ENSPTRP00000046569          EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKTVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATF
M_mulatta_ENSMMUP00000034400              EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQIQLDKLKKTNVFNATF
M_musculus_ENSMUSP00000040094             EILE-QMNEDDS--EQLQ-------RELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATF
C_familiaris_ENSCAFP00000021764           EILE-QMNEDDS--EQLQ-------MELRELALEEERLIQELEEVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF
B_taurus_ENSBTAP00000026531               EILE-QMNEDDS--EQLG-------LELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF
R_norvegicus_ENSRNOP00000027868           EMLE-QMNEGDS--EQLQ-------RELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF
E_caballus_ENSECAP00000016069             EILE-QMNEDDS--EQLQ-------MELEELALEEERLIRELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF
M_domestica_ENSMODP00000018835            EILE-QMNEDDE--EKLK-------MELKELALEEERLIQELEDVEKNRKIVAEDLEKVQAETERLD--QEEAQYQREYSEFKRQQLELDDELKSVDNQMRYAQIQLDKLKKTNVFNATF
P_pygmaeus_ENSPPYP00000009414             EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMQWEMSKVLSNPYISPHLSAF
G_gallus_ENSGALP00000004697               EILE-KMNEDDK--EKLQ-------TELKELALEEEQLIQELEDVEKNRKIVAEDFERVRAEAERLE--QEEAQYQKEYCEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF
A_carolinensis_ENSACAP00000013592         EILE-QMNEDDK--ERLQ-------LELKEFALEEERLIEELEEVEQKRKAMAEDFDKVRAEAERLD--QEEAEYQKEYSEFKRQQLELDDDLKSVDNQMRYAQMQLDKLKKTNVFNATF
X_tropicalis_ENSXETP00000027611           EILE-RMNEDDK--EKLE-------AKLKELAEDEDRLIQELEEVERNRELVAKDIEKVREEAERLE--QEEARYQKEYSEFKRQQLELDDDLKSVENQMRYAQIQLDKLKKTNVFNATF
T_guttata_ENSTGUP00000002874              EILE-QMNEDDK--EKLQ-------TELKELALEEEQLIQELEDVEKNRKIVAEDFERVRAEAERLE--QEEAQYQKEYCEFKRQQLELDDELKSVDNQMRYAQMQLDKLKKTNVFNATF
G_aculeatus_ENSGACP00000008498            ELLS-HLQVEGE--ETLL-------AELRQLNEEEEALVQELEAVEEQRAAVSQDLNQSRVHSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF
G_gorilla_ENSGGOP00000001565              EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAXXXXXXXXXXXXXXXXXXXXXXXENQMRYAQMQLDKLKKTNVFNATF
T_nigroviridis_ENSTNIP00000014523         ELLS-NLPVEDE--ETLL-------AELQQLKEEEAALVEELEAVEEQRAAVAEDLAQCRGPLRETDWMQRRLQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF
T_rubripes_ENSTRUP00000034988             ELLS-NLQVEDE--ETLL-------AELQQLKEEEAALVEELETVEEQRAAVADDLAQCRVHSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF
O_cuniculus_ENSOCUP00000013727            EILE-QMNEDDS--EQLQ-------KELRELALEEERLVQELEDVEKNRRTVAESLEKVQAEAERLD--QEEAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
O_latipes_ENSORLP00000005780              ELLS-NLQAEDE--KTLL-------AELQELKDEEASLVQELEAVEEQRAAVAQDLAQSRIQSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF
O_anatinus_ENSOANP00000019267             EILE-QMNEEDK--EKLQ-------MELKELMLEEERLIQELEAVEQSRQAVAENFEKVQAEAERLD--HEEAQYQKEYSEFKRQQLELDDELKSVDNQMRYAQMQLDKLKKTNVFNATF
M_mulatta_ENSMMUP00000002276              ETGMLATSEDQT--AALR-------AELRDLELEEARLVQELEDVDRSNARAATDLEAAQAEAAELD--QQERRYYREYSALKWQQLELLDQLGNVENQLQYARVQMDRLKEINCFTATF
A_aegypti_AAEL010427-PA                   KKLELTDDVPNV--DLLE-------KELNDLKGEEERLLQELSELSREEDAIKLAVKEQEVEKQRLG--NEEEKYWREYTKHRRDVITTEDEFRSLECQLSYAQLQLDKLKKTNVFNVTF
P_troglodytes_ENSPTRP00000056655          ETGELATSEDET--AALR-------AELRDLELEEARLVQELEDVDRNNARAAAHLEAAQAEAAELD--QQERQHYRDYSALKWQQLELLDQLGHVENQLQYARVQMDRLKEINCFTATF
P_pygmaeus_ENSPPYP00000000063             ETGELATSEDEP--AALW-------AELRDLKLEEARLVQELEDVDRNNARAAADLEAAQAEAAELD--QQERQYYRDYSALKWQQLELLDQLGNVENQLQYARVQMDRLEEINCFTATF
A_gambiae_AGAP003858-PA                   KKLEMTDDVPNI--DELE-------QELAGLKEDETRLLEELSSLSREEQSIRQAVEEQEKEKQRLE--REENKYWREYTKHRRDVITTEDEFRSLECQMAYAQSQLEKLKKTNVFNATF
C_intestinalis_ENSCINP00000019537         SVLE-EDKCDHELVAKLT-------QDLDNLKVEENEILAQLSETEKEREVVKKELEETQKQQEALQ--REEEKHLQEYSELRVQQIELEEEQCSADLQLMHTDQHLTKLRKTNVFNSTF
E_caballus_ENSECAP00000015556             ETRE-RMSEDER--ETLQ-------EELKGLELEEARLVQELEEVDKNRERAAADLKAAQAETEMLD--QHDRQFWRDYSQLKWQQLELHDELRSVENRLRHAQTQLDWLEKINVFSVTF
D_melanogaster_FBpp0083975                DELEQQRVAPNV--EALD-------KELDELKRSEQQLLSELKELKKEEQSLNDAIAEEEQEREELH--EQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLDKLRDTNIFNITF
O_cuniculus_ENSOCUP00000015004            ESGE-LQVEPET--ESLQ-------AELRALELEEARLARELEDVDKGCARVAAALQEAEAETQELE--QRERQSHREYSALKWQQLELCDQLGSIENQLWYAQAQLHWLNKTSIFQVTF
G_gorilla_ENSGGOP00000007989              ETGELATGEDET--AALR-------AELRDLELEEARLVQELEDVDRNNARAAADLEAAQAEAAELD--QQKRQHYRDYSALKWQQLELLDQLGNVENQLQYARVQMDRLKEINCFTATF
C_familiaris_ENSCAFP00000023183           G----RICEEEM--KTLQ-------EELEGLELEEARLVQELKEVENKQERVAEDLEAAQAETEMLE--QQDKQYWKDYSNLKWQQLELQDELKSMERQLRHAQIQWGRLKKTSVFSATF
R_norvegicus_ENSRNOP00000054742           ERQS-LVSEEET--EALH---AELRAELSGLEQEEARLVQELEDLDGHHARVAAELRAAQAESKELY--QQNEEHRASYSVLKMEQLELTDQLSSVENQLQYALGQLCHLRKTSIFDATF
S_cerevisiae_YPL120W                      SKLESQNKEISE--SNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLE--NEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATF
C_elegans_T19E7.3.1                       NYLKENHPTTSI--PDLK-------AKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAAS--EKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCF

                                                  370       380       390       400       410       420       430       440       450       460       470       480
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000355231                 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
P_troglodytes_ENSPTRP00000046569          HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
M_mulatta_ENSMMUP00000034400              HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
M_musculus_ENSMUSP00000040094             HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
C_familiaris_ENSCAFP00000021764           HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
B_taurus_ENSBTAP00000026531               HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
R_norvegicus_ENSRNOP00000027868           HIWHSGQFGTINNFRLGRLPSAPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
E_caballus_ENSECAP00000016069             HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
M_domestica_ENSMODP00000018835            HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
P_pygmaeus_ENSPPYP00000009414             LCRHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
G_gallus_ENSGALP00000004697               HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
A_carolinensis_ENSACAP00000013592         HIWHSGQFGTINNFRLGRLPCVPVEWNEINAAWGQTVLLLHALANKMGLTFQRYRLIPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
X_tropicalis_ENSXETP00000027611           HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLQFQRYRLMPFGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
T_guttata_ENSTGUP00000002874              HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
G_aculeatus_ENSGACP00000008498            HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
G_gorilla_ENSGGOP00000001565              HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
T_nigroviridis_ENSTNIP00000014523         HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFKRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
T_rubripes_ENSTRUP00000034988             HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFKRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
O_cuniculus_ENSOCUP00000013727            XXXHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GXRFFW--D-KFDHAMVAFLD
O_latipes_ENSORLP00000005780              HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLCFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
O_anatinus_ENSOANP00000019267             HIWHSGQFGTINTFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD
M_mulatta_ENSMMUP00000002276              EIWVEGSLGVINNFRLGCLPTVPVGWNEINAAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDEGTE--------------LPLFSYG----GQDVFL--NNKFDRAMVALLD
A_aegypti_AAEL010427-PA                   HIWHSGHFGTINNFRLGRLPSSPVDWAEINAAWGQTCLLLSALARTMNLTFKNYRLVPYGNHSHIEVLSD-GKE--------------LPLYGSG----GFRFFW--DTKFDAAMVAFLD
P_troglodytes_ENSPTRP00000056655          EIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRAE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD
P_pygmaeus_ENSPPYP00000000063             EICVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRTE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD
A_gambiae_AGAP003858-PA                   HIWHSGHFGTINNFRLGRLPSAPVDWSEINAAWGQTCLLLSALARKMNFSFKQYRLVPYGNHSYIEVLGE-GKE--------------LPLYGNG----GFRFLW--DSKYDAAMVAFLD
C_intestinalis_ENSCINP00000019537         HIWHQGHFGTINGFRLGRLPGVHVEWTEINAAWGQVVLLLSSLAKKMGLKMKRYKLVPFGNHSYIESLDDKAKD--------------LPLYGSG----GLRFLW--DTKFDQAMVAFLD
E_caballus_ENSECAP00000015556             EIGHSGPVGVINNFRLGCLPSVPVCWEEINAAWGQTALLLLALSNTIGLQFQRYRLVPCGDHSYLKSVRDDSIE--------------LPLFCTG----RQGAF---ERQFDRAMVAFLD
D_melanogaster_FBpp0083975                HIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFERYRVVPFGNHSYVEVLGE-NRE--------------LPLYGSG----GFKFFW--DTKFDAAMVAFLD
O_cuniculus_ENSOCUP00000015004            EIREEGSVGIINNLRLGCLPIGPVDWNEINAAWGQVALLLLALSNTIGLEFQRYQLIPCADHSYLKPLTGNSAL--------------LPLFSDG----SQNVFL--SNKFDRAMIAFLD
G_gorilla_ENSGGOP00000007989              EIWVEGPLGVINNFRLGRLPTVSVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRTE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD
C_familiaris_ENSCAFP00000023183           EIRYDGPVGIINSFRLGCLPTVPVSWKEINMAWGQTALLLLALSNKIGLEFRRYQLIPCGNRSYLKSLTNDPVE--------------LPLFCIM----RQSTCL--DLKFDQAMMAFLD
R_norvegicus_ENSRNOP00000054742           TISDDGPLGMINNFRLGCLPAVRVGWTEINAAWGQTALLLFSLSKMAGLQFQRYQLVPLGDHSYLKSLTADEV---------------LPLFSDG----NHSVFL--NNTFDCAMKAFLD
S_cerevisiae_YPL120W                      KISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRK--ETKFDKSLETTLE
C_elegans_T19E7.3.1                       HIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIK-LRRNGID--------------METYALY----GQGTPLSGSSGIDPGIRRFLQ

                                                  490       500       510       520       530       540       550       560       570       580       590       600
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000355231                 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
P_troglodytes_ENSPTRP00000046569          CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
M_mulatta_ENSMMUP00000034400              CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
M_musculus_ENSMUSP00000040094             CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
C_familiaris_ENSCAFP00000021764           CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
B_taurus_ENSBTAP00000026531               CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
R_norvegicus_ENSRNOP00000027868           CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
E_caballus_ENSECAP00000016069             CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
M_domestica_ENSMODP00000018835            CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
P_pygmaeus_ENSPPYP00000009414             CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
G_gallus_ENSGALP00000004697               CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
A_carolinensis_ENSACAP00000013592         CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
X_tropicalis_ENSXETP00000027611           CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
T_guttata_ENSTGUP00000002874              CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
G_aculeatus_ENSGACP00000008498            CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R----------
G_gorilla_ENSGGOP00000001565              CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
T_nigroviridis_ENSTNIP00000014523         CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R----------
T_rubripes_ENSTRUP00000034988             CVQQFKEE---------------------------VEKGDTGFCLPYSIRMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R----------
O_cuniculus_ENSOCUP00000013727            CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
O_latipes_ENSORLP00000005780              CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R----------
O_anatinus_ENSOANP00000019267             CVQQFKEE---------------------------VEKGNPELCLCD--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K----------
M_mulatta_ENSMMUP00000002276              CMQQFKEE---------------------------AEKGELGLCLPY--RIQVETGLMEDAGGRGECYSIRTHLNTQE-LWTKALKFLLINLKWSLIWVASRYQK---------------
A_aegypti_AAEL010427-PA                   CLQQFKEE---------------------------VVKKDPDFCLPY--RM--EKGKIEDS-ATGNSYSIKIQFNSEE-QWTKALKFLLTNLKWGLTWVSSQFTEEKPSA----------
P_troglodytes_ENSPTRP00000056655          CMQQFKEE---------------------------AEKGELGLSLPY--GIQVETGLMEDVGGRGECYSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK---------------
P_pygmaeus_ENSPPYP00000000063             CMQQFKEE---------------------------AEKGELGLCLPY--RIQVGTGLMEDVGGRGECYSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK---------------
A_gambiae_AGAP003858-PA                   CLQQFKEE---------------------------IVRRDPDFCLPY--LM--EKGKIEDA-STGSSFSIKIQFNSEE-QWTKALKYLLTNLKWVLTWVSSQFTEDK-QR----------
C_intestinalis_ENSCINP00000019537         CLQQFKEA---------------------------VE-GNSGFSLPY--RM--EKGKIEDTGGSGASYSIKMQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFTP----S----------
E_caballus_ENSECAP00000015556             CLQHFNKE---------------------------AKKGESGLCLPH--RIHVSKGLMEDPGGGGAFYSIRTHFNTEE-RWTKALKLMLVNFKWSLAWVSLRYRQ----K----------
D_melanogaster_FBpp0083975                CLTQFQKE---------------------------VEKRDTEFLLPY--KM--EKGKIIDP-STGNSYSIKIQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFVS----P----------
O_cuniculus_ENSOCUP00000015004            CLQQFKEK---------------------------AEKGKQGLRLPY--RIRVEEGLLEDSTGSGECCALRSHLNTRE-QWTRALKFMLVNLKCSLAWASLRYQK---------------
G_gorilla_ENSGGOP00000007989              CMQQFKEE---------------------------AEKGELGLSLPY--GIQVETGLMEDVDGRGECCSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK---------------
C_familiaris_ENSCAFP00000023183           CMQQFKEE---------------------------AEKGKWGLCLPC--RIHVKNGLMEDSGSTGEFYSIRTYLNTEE-QWTKALKLMLINLKCSLTWVSLRYQE---------------
R_norvegicus_ENSRNOP00000054742           CLQQFVEE---------------------------TEKDERYPCLPY--RIHPLEGVMEDIGDSGDCCPIRTHLNTEE-EWSRALKFMLADLKLIVAWAS--------------------
S_cerevisiae_YPL120W                      IISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPY--IM--NKDKI-------NGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTI
C_elegans_T19E7.3.1                       LLEFLLKE---------------------------LKDRNKNFKPPY--QIHADS--LVD---NGVKYNAVMTLNTDV-RWTRAMALMLTDLKAACAQCDALRSP----I----------

                                                  610
                                          ===
H_sapiens_ENSP00000355231                 ---
P_troglodytes_ENSPTRP00000046569          ---
M_mulatta_ENSMMUP00000034400              ---
M_musculus_ENSMUSP00000040094             ---
C_familiaris_ENSCAFP00000021764           ---
B_taurus_ENSBTAP00000026531               ---
R_norvegicus_ENSRNOP00000027868           ---
E_caballus_ENSECAP00000016069             ---
M_domestica_ENSMODP00000018835            ---
P_pygmaeus_ENSPPYP00000009414             ---
G_gallus_ENSGALP00000004697               ---
A_carolinensis_ENSACAP00000013592         ---
X_tropicalis_ENSXETP00000027611           ---
T_guttata_ENSTGUP00000002874              ---
G_aculeatus_ENSGACP00000008498            ---
G_gorilla_ENSGGOP00000001565              ---
T_nigroviridis_ENSTNIP00000014523         ---
T_rubripes_ENSTRUP00000034988             ---
O_cuniculus_ENSOCUP00000013727            ---
O_latipes_ENSORLP00000005780              ---
O_anatinus_ENSOANP00000019267             ---
M_mulatta_ENSMMUP00000002276              ---
A_aegypti_AAEL010427-PA                   ---
P_troglodytes_ENSPTRP00000056655          ---
P_pygmaeus_ENSPPYP00000000063             ---
A_gambiae_AGAP003858-PA                   ---
C_intestinalis_ENSCINP00000019537         ---
E_caballus_ENSECAP00000015556             ---
D_melanogaster_FBpp0083975                ---
O_cuniculus_ENSOCUP00000015004            ---
G_gorilla_ENSGGOP00000007989              ---
C_familiaris_ENSCAFP00000023183           ---
R_norvegicus_ENSRNOP00000054742           ---
S_cerevisiae_YPL120W                      SGN
C_elegans_T19E7.3.1                       ---