10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000355231 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE P_troglodytes_ENSPTRP00000046569 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE M_mulatta_ENSMMUP00000034400 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE M_musculus_ENSMUSP00000040094 MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------EANSGEE C_familiaris_ENSCAFP00000021764 MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQVK---------------------PGETQEE--------------------------------EANSGEE B_taurus_ENSBTAP00000026531 MEGSKTS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQLK---------------------PGETQEE--------------------------------EANSGEE R_norvegicus_ENSRNOP00000027868 MEGSKAS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGESQEE--------------------------------EANSGEE E_caballus_ENSECAP00000016069 MEGSKTS-SSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLATAQVK---------------------PGETQEE--------------------------------EANSGEE M_domestica_ENSMODP00000018835 MEGSKSS-SSTMQVSFVCQRCSQPLKLDTSFKILDQVTIRELTAPLLTTAQTK---------------------PGETQEE--------------------------------ETNSGEE P_pygmaeus_ENSPPYP00000009414 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE G_gallus_ENSGALP00000004697 MEGGRAP-ACTTQVSFVCQRCSQPLKLDTSFKILDRLTIQELTAPLLTAAPAR---------------------PGDAQEE---------------------------------SALSEE A_carolinensis_ENSACAP00000013592 MDGSKSP-ACTMQVSFVCQRCSQPLKLDTSFKVLDKVTIQELTAPLLTTTPAK---------------------LGDAQEE--------------------------------ETTLTEE X_tropicalis_ENSXETP00000027611 METSK---SSTMQVSFVCQRCSQPLKLDTSFKILDKVTMQELTAPLVTTAAVK---------------------PGDIQEV--------------------------------DSNI-EE T_guttata_ENSTGUP00000002874 ----------------------QSIKLDTSLKVLGHLTIQEVPAPLGSAAPAR---------------------PGDPHEE--------------------------------ESALSEE G_aculeatus_ENSGACP00000008498 MEGSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTIQDLIAPLVTVTPSK---------------------QADRNVG--------------------------------ET-APEE G_gorilla_ENSGGOP00000001565 --------------------------------------------PLLTTAQAK---------------------PGETQEE--------------------------------ETNSGEE T_nigroviridis_ENSTNIP00000014523 MEVSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTVQELTAPLVTVTPSR---------------------QAESSAG--------------------------------ET-APEE T_rubripes_ENSTRUP00000034988 MEVSKSS-STTMQVSFVCQRCCQPLKLDTSFNVLDRVTVHELTAPLVTVTPSK---------------------QAESSEG--------------------------------ET-APEE O_cuniculus_ENSOCUP00000013727 VEGSKMP-TSTIQVSFVC-RCSQPLKLDXXXXXXXXXXXXXXXXPLLATAQVK---------------------PGDPQEE--------------------------------EANSGEE O_latipes_ENSORLP00000005780 -----------------------------------------------------------------------------------------------------------------------E O_anatinus_ENSOANP00000019267 -------------------------------------------APLLSAAQAK---------------------PTEAHEE--------------------------------EPRAGEE M_mulatta_ENSMMUP00000002276 ---AGVSPSAMTSIRFLCQRCHQALRLSCSSESGSL-----PAAAAPTSGQAG---------------------PGDTPEP--------------------------------GATTSEV A_aegypti_AAEL010427-PA ------MNDAKVSVGFSCQRCLQPIHIDDSFAALGEHTLAELALPINSHMEVD------------------------------------------------------------------- P_troglodytes_ENSPTRP00000056655 MRGSGTEGGSMSSIRFLCQRCHQALKLSCSSESRSL-----PATPAPTSGQAE---------------------PGDTREP--------------------------------GVTTREV P_pygmaeus_ENSPPYP00000000063 MRGSGTEGGSMSSIRFLCQRCHQALKLSCSSESGSL-----PAAPAPTSGQAE---------------------PGDTREP--------------------------------GATTREV A_gambiae_AGAP003858-PA ------MNDAKVSVSFSCQRCMQPIHVDDTFASLGEHTLAELALPINSHLEVD------------------------------------------------------------------- C_intestinalis_ENSCINP00000019537 --------MTDESICFMCARCKQVIKLDRSFDSIDKQTLQELTSSSRTSTPSEETVAKIDDESQQQLQASSSSDENPPQEQ--------------------------------EVSSSGS E_caballus_ENSECAP00000015556 --HGESQPSAMSSIHFMCWRCDQPLKLNQSTETPGLDATQASAASALASAEGA---------------------PRETQEG--------------------------------GPTSREE D_melanogaster_FBpp0083975 -----MSEAEKQAVSFACQRCLQPIVLDEQLEKISVHAMAELSLPIYGDNGNT------------------------------------------------------------------- O_cuniculus_ENSOCUP00000015004 -PKVKVKTSAMSPI-FICQRCSQPLKLSEPLEML-------------ASTQGE---------------------QGESQET--------------------------------GTSSEKM G_gorilla_ENSGGOP00000007989 MRGSGTEGGXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXX---------------------XXXXXXX--------------------------------XXXXXXX C_familiaris_ENSCAFP00000023183 -IRVRAEAFTMSSIRFICQGCRQPMRLSQSTGTLGLETTQRPAASTFTSAQQE---------------------PRETLVR--------------------------------GPTSKVE R_norvegicus_ENSRNOP00000054742 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YPL120W ---------------MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATN-----ENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANIT C_elegans_T19E7.3.1 ---------MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALT-------------------------------------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000355231 PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL P_troglodytes_ENSPTRP00000046569 PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL M_mulatta_ENSMMUP00000034400 PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL M_musculus_ENSMUSP00000040094 PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL C_familiaris_ENSCAFP00000021764 PFLET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL B_taurus_ENSBTAP00000026531 PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL R_norvegicus_ENSRNOP00000027868 PFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL E_caballus_ENSECAP00000016069 PFIET-CQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL M_domestica_ENSMODP00000018835 PFAET-RQDG-VSRRYIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKASLPIEGVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL P_pygmaeus_ENSPPYP00000009414 PFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL G_gallus_ENSGALP00000004697 AFTEG-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL A_carolinensis_ENSACAP00000013592 IFVEN-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------ASCDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL X_tropicalis_ENSXETP00000027611 TFAEN-RTDG-VSRRLIPPARMM--STESATSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL T_guttata_ENSTGUP00000002874 AFVEH-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAI-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL G_aculeatus_ENSGACP00000008498 TFVEN-KQDG-VSRKYIPPARVM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL G_gorilla_ENSGGOP00000001565 TFIETPRQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCL T_nigroviridis_ENSTNIP00000014523 AFVEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL T_rubripes_ENSTRUP00000034988 AFVEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-EASDCG----------NMEHLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL O_cuniculus_ENSOCUP00000013727 AFIET-RQDG-VSRRFIPPARMM--STESANSFTLIG-EASDGG----------TMENLSRRLKAT-----VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLHVTENECQNYKRCL O_latipes_ENSORLP00000005780 TFEEN-KQDG-VSRKYIPPARMM--STESANSFTLIG-DASDGG----------TMENLSRRLK-------VTSDLFDIMSGQTDVDHPLCEECTDTLLDHLDTQLNITENECQNYKQCL O_anatinus_ENSOANP00000019267 AFTET-RQDG-VSRRFIPPARRD--SSLATSAQLQAGARAGQRN----------PVLPLSSALL-------VTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNITENECQNYKRCL M_mulatta_ENSMMUP00000002276 TDAEE-PQDG-ASSRPLPGDGSV--SKDQANVFTLLG-ELG-------------AMQTLSSIQK-------AAGDIFDIVSGQEDVDHPLCEECTDSLLEQLDIQLALTEAESQNYQRCL A_aegypti_AAEL010427-PA ---IE-SQSA-SMDHFVPPFRFAECSGTDTNGFMLLS-DGP-------------DRDLLSQNLR-------VKAELFDTLSNNSEIDHPLCDECTDTLLELMDKQLKMAEDEWNDYNNYL P_troglodytes_ENSPTRP00000056655 TDAEE-QQDG-ASSRPLPGDGSV--SKDHANIFTLLG-ELG-------------AMHMLSSIQK-------AAGDIFDMVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCL P_pygmaeus_ENSPPYP00000000063 TDAGE-QQDG-ASSRSLPGDGSV--SKDHANIFTLLG-ELG-------------AMHMLGSIQK-------AAGDIFDIVSGQEVVDHPLCEECTDSLLEHLDIQLALTEAESQNYQRCL A_gambiae_AGAP003858-PA ---LE-SQSV-SFDHFVPPFRVTD-STNDTNGFMLLS-DGQ-------------NKESLGHSLR-------VKAELFDALSNNSEIDHPLCDECTDTLLELMDKQLKIAEDEWNDYNNYL C_intestinalis_ENSCINP00000019537 DNPND-VEDS-IYSQNAASSGNE--VHESTNSFTFIG-DT--------------SMENLSHKMK-------VIVRLFDLMSDNSDLEHPLCEECTEALLGELNKELKSTETEATLYKNYL E_caballus_ENSECAP00000015556 TDSDE-LQDG-ASCRTLPGDGRM--SGDSSNYFILLG-KLS-------------SVRTLNSIQK-------AARDIFDILSSEKAVNQPLCEDCTDNLLLQLDSQLVLTASESENYQRFL D_melanogaster_FBpp0083975 ---LD-PQDASSFDHFVPPYRLT--DSINGTGFMLVS-DGR-------------DNKKMSAAFK-------LKAELFDCLSSNSEIDHPLCEECADSMLEIMDRELRIAEDEWDVYKAYL O_cuniculus_ENSOCUP00000015004 RGSEK-LQVG-ASGGALPEDSNT---SEDSGGFTLLG-DVC-------------SVGTLSSLQE-------ATVQIFDILSGQKDVEHPLCEECTDNLLEQLDSQLTLVELDTQNYKRCL G_gorilla_ENSGGOP00000007989 XXXXX-XXXX-XXXXXXXXXXXX--XXXXXXXXXXXX-XXX-------------XMHMLSSIQK-------AAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCL C_familiaris_ENSCAFP00000023183 IDTEK-LPD--ASCSTLPGDGKM--FGDSPKNFILLG-KFD-------------SARTLSNIQN-------TTRDIFDILTGEKYVDHPLCEDCTDKLLEVLDTQLIIVDSENEHYKYWR R_norvegicus_ENSRNOP00000054742 -------------------------------TFTLLG-ESV-------------SVRTLHTVQN-------TTIEIFEILSEQKVVDHPLCVDCTDNLLVQLDDQLTLVASDNQSYQGFL S_cerevisiae_YPL120W SNSREDQRYGNANGNDNKKANSD--TSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVN-------AMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFL C_elegans_T19E7.3.1 --------------------------GHSRNLMKLIS-------------------------------------------DAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYI 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000355231 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATF P_troglodytes_ENSPTRP00000046569 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKTVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNATF M_mulatta_ENSMMUP00000034400 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQIQLDKLKKTNVFNATF M_musculus_ENSMUSP00000040094 EILE-QMNEDDS--EQLQ-------RELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATF C_familiaris_ENSCAFP00000021764 EILE-QMNEDDS--EQLQ-------MELRELALEEERLIQELEEVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF B_taurus_ENSBTAP00000026531 EILE-QMNEDDS--EQLG-------LELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF R_norvegicus_ENSRNOP00000027868 EMLE-QMNEGDS--EQLQ-------RELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF E_caballus_ENSECAP00000016069 EILE-QMNEDDS--EQLQ-------MELEELALEEERLIRELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF M_domestica_ENSMODP00000018835 EILE-QMNEDDE--EKLK-------MELKELALEEERLIQELEDVEKNRKIVAEDLEKVQAETERLD--QEEAQYQREYSEFKRQQLELDDELKSVDNQMRYAQIQLDKLKKTNVFNATF P_pygmaeus_ENSPPYP00000009414 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAQYQREYSEFKRQQLELDDELKSVENQMQWEMSKVLSNPYISPHLSAF G_gallus_ENSGALP00000004697 EILE-KMNEDDK--EKLQ-------TELKELALEEEQLIQELEDVEKNRKIVAEDFERVRAEAERLE--QEEAQYQKEYCEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATF A_carolinensis_ENSACAP00000013592 EILE-QMNEDDK--ERLQ-------LELKEFALEEERLIEELEEVEQKRKAMAEDFDKVRAEAERLD--QEEAEYQKEYSEFKRQQLELDDDLKSVDNQMRYAQMQLDKLKKTNVFNATF X_tropicalis_ENSXETP00000027611 EILE-RMNEDDK--EKLE-------AKLKELAEDEDRLIQELEEVERNRELVAKDIEKVREEAERLE--QEEARYQKEYSEFKRQQLELDDDLKSVENQMRYAQIQLDKLKKTNVFNATF T_guttata_ENSTGUP00000002874 EILE-QMNEDDK--EKLQ-------TELKELALEEEQLIQELEDVEKNRKIVAEDFERVRAEAERLE--QEEAQYQKEYCEFKRQQLELDDELKSVDNQMRYAQMQLDKLKKTNVFNATF G_aculeatus_ENSGACP00000008498 ELLS-HLQVEGE--ETLL-------AELRQLNEEEEALVQELEAVEEQRAAVSQDLNQSRVHSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF G_gorilla_ENSGGOP00000001565 EILE-QMNEDDS--EQLQ-------MELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLD--QEEAXXXXXXXXXXXXXXXXXXXXXXXENQMRYAQMQLDKLKKTNVFNATF T_nigroviridis_ENSTNIP00000014523 ELLS-NLPVEDE--ETLL-------AELQQLKEEEAALVEELEAVEEQRAAVAEDLAQCRGPLRETDWMQRRLQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF T_rubripes_ENSTRUP00000034988 ELLS-NLQVEDE--ETLL-------AELQQLKEEEAALVEELETVEEQRAAVADDLAQCRVHSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF O_cuniculus_ENSOCUP00000013727 EILE-QMNEDDS--EQLQ-------KELRELALEEERLVQELEDVEKNRRTVAESLEKVQAEAERLD--QEEAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX O_latipes_ENSORLP00000005780 ELLS-NLQAEDE--KTLL-------AELQELKDEEASLVQELEAVEEQRAAVAQDLAQSRIQSQQLD--TEELQYQKEYSEFKRQQLELDDELKSVDNQMRYCQIQLDRLKKTNVFNATF O_anatinus_ENSOANP00000019267 EILE-QMNEEDK--EKLQ-------MELKELMLEEERLIQELEAVEQSRQAVAENFEKVQAEAERLD--HEEAQYQKEYSEFKRQQLELDDELKSVDNQMRYAQMQLDKLKKTNVFNATF M_mulatta_ENSMMUP00000002276 ETGMLATSEDQT--AALR-------AELRDLELEEARLVQELEDVDRSNARAATDLEAAQAEAAELD--QQERRYYREYSALKWQQLELLDQLGNVENQLQYARVQMDRLKEINCFTATF A_aegypti_AAEL010427-PA KKLELTDDVPNV--DLLE-------KELNDLKGEEERLLQELSELSREEDAIKLAVKEQEVEKQRLG--NEEEKYWREYTKHRRDVITTEDEFRSLECQLSYAQLQLDKLKKTNVFNVTF P_troglodytes_ENSPTRP00000056655 ETGELATSEDET--AALR-------AELRDLELEEARLVQELEDVDRNNARAAAHLEAAQAEAAELD--QQERQHYRDYSALKWQQLELLDQLGHVENQLQYARVQMDRLKEINCFTATF P_pygmaeus_ENSPPYP00000000063 ETGELATSEDEP--AALW-------AELRDLKLEEARLVQELEDVDRNNARAAADLEAAQAEAAELD--QQERQYYRDYSALKWQQLELLDQLGNVENQLQYARVQMDRLEEINCFTATF A_gambiae_AGAP003858-PA KKLEMTDDVPNI--DELE-------QELAGLKEDETRLLEELSSLSREEQSIRQAVEEQEKEKQRLE--REENKYWREYTKHRRDVITTEDEFRSLECQMAYAQSQLEKLKKTNVFNATF C_intestinalis_ENSCINP00000019537 SVLE-EDKCDHELVAKLT-------QDLDNLKVEENEILAQLSETEKEREVVKKELEETQKQQEALQ--REEEKHLQEYSELRVQQIELEEEQCSADLQLMHTDQHLTKLRKTNVFNSTF E_caballus_ENSECAP00000015556 ETRE-RMSEDER--ETLQ-------EELKGLELEEARLVQELEEVDKNRERAAADLKAAQAETEMLD--QHDRQFWRDYSQLKWQQLELHDELRSVENRLRHAQTQLDWLEKINVFSVTF D_melanogaster_FBpp0083975 DELEQQRVAPNV--EALD-------KELDELKRSEQQLLSELKELKKEEQSLNDAIAEEEQEREELH--EQEESYWREYTKHRRELMLTEDDKRSLECQIAYSKQQLDKLRDTNIFNITF O_cuniculus_ENSOCUP00000015004 ESGE-LQVEPET--ESLQ-------AELRALELEEARLARELEDVDKGCARVAAALQEAEAETQELE--QRERQSHREYSALKWQQLELCDQLGSIENQLWYAQAQLHWLNKTSIFQVTF G_gorilla_ENSGGOP00000007989 ETGELATGEDET--AALR-------AELRDLELEEARLVQELEDVDRNNARAAADLEAAQAEAAELD--QQKRQHYRDYSALKWQQLELLDQLGNVENQLQYARVQMDRLKEINCFTATF C_familiaris_ENSCAFP00000023183 G----RICEEEM--KTLQ-------EELEGLELEEARLVQELKEVENKQERVAEDLEAAQAETEMLE--QQDKQYWKDYSNLKWQQLELQDELKSMERQLRHAQIQWGRLKKTSVFSATF R_norvegicus_ENSRNOP00000054742 ERQS-LVSEEET--EALH---AELRAELSGLEQEEARLVQELEDLDGHHARVAAELRAAQAESKELY--QQNEEHRASYSVLKMEQLELTDQLSSVENQLQYALGQLCHLRKTSIFDATF S_cerevisiae_YPL120W SKLESQNKEISE--SNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLE--NEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATF C_elegans_T19E7.3.1 NYLKENHPTTSI--PDLK-------AKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAAS--EKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCF 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000355231 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD P_troglodytes_ENSPTRP00000046569 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD M_mulatta_ENSMMUP00000034400 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD M_musculus_ENSMUSP00000040094 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD C_familiaris_ENSCAFP00000021764 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD B_taurus_ENSBTAP00000026531 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD R_norvegicus_ENSRNOP00000027868 HIWHSGQFGTINNFRLGRLPSAPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD E_caballus_ENSECAP00000016069 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD M_domestica_ENSMODP00000018835 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD P_pygmaeus_ENSPPYP00000009414 LCRHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD G_gallus_ENSGALP00000004697 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD A_carolinensis_ENSACAP00000013592 HIWHSGQFGTINNFRLGRLPCVPVEWNEINAAWGQTVLLLHALANKMGLTFQRYRLIPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD X_tropicalis_ENSXETP00000027611 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLQFQRYRLMPFGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD T_guttata_ENSTGUP00000002874 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD G_aculeatus_ENSGACP00000008498 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD G_gorilla_ENSGGOP00000001565 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD T_nigroviridis_ENSTNIP00000014523 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFKRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD T_rubripes_ENSTRUP00000034988 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFKRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD O_cuniculus_ENSOCUP00000013727 XXXHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GXRFFW--D-KFDHAMVAFLD O_latipes_ENSORLP00000005780 HIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLCFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD O_anatinus_ENSOANP00000019267 HIWHSGQFGTINTFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLRFQRYRLVPYGNHSYLESLTDKSKE--------------LPLYCSG----GLRFFW--DNKFDHAMVAFLD M_mulatta_ENSMMUP00000002276 EIWVEGSLGVINNFRLGCLPTVPVGWNEINAAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDEGTE--------------LPLFSYG----GQDVFL--NNKFDRAMVALLD A_aegypti_AAEL010427-PA HIWHSGHFGTINNFRLGRLPSSPVDWAEINAAWGQTCLLLSALARTMNLTFKNYRLVPYGNHSHIEVLSD-GKE--------------LPLYGSG----GFRFFW--DTKFDAAMVAFLD P_troglodytes_ENSPTRP00000056655 EIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRAE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD P_pygmaeus_ENSPPYP00000000063 EICVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRTE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD A_gambiae_AGAP003858-PA HIWHSGHFGTINNFRLGRLPSAPVDWSEINAAWGQTCLLLSALARKMNFSFKQYRLVPYGNHSYIEVLGE-GKE--------------LPLYGNG----GFRFLW--DSKYDAAMVAFLD C_intestinalis_ENSCINP00000019537 HIWHQGHFGTINGFRLGRLPGVHVEWTEINAAWGQVVLLLSSLAKKMGLKMKRYKLVPFGNHSYIESLDDKAKD--------------LPLYGSG----GLRFLW--DTKFDQAMVAFLD E_caballus_ENSECAP00000015556 EIGHSGPVGVINNFRLGCLPSVPVCWEEINAAWGQTALLLLALSNTIGLQFQRYRLVPCGDHSYLKSVRDDSIE--------------LPLFCTG----RQGAF---ERQFDRAMVAFLD D_melanogaster_FBpp0083975 HIWHAGHFGTINNFRLGRLPSVSVDWSEINAAWGQTVLLLSALARKIGLTFERYRVVPFGNHSYVEVLGE-NRE--------------LPLYGSG----GFKFFW--DTKFDAAMVAFLD O_cuniculus_ENSOCUP00000015004 EIREEGSVGIINNLRLGCLPIGPVDWNEINAAWGQVALLLLALSNTIGLEFQRYQLIPCADHSYLKPLTGNSAL--------------LPLFSDG----SQNVFL--SNKFDRAMIAFLD G_gorilla_ENSGGOP00000007989 EIWVEGPLGVINNFRLGRLPTVSVGWNEINTAWGQAALLLLALANTIGLQFQRYRLIPCGNHSYLKSLTDDRTE--------------LPLFCYG----GQDVFL--DNKYDRAMVAFLD C_familiaris_ENSCAFP00000023183 EIRYDGPVGIINSFRLGCLPTVPVSWKEINMAWGQTALLLLALSNKIGLEFRRYQLIPCGNRSYLKSLTNDPVE--------------LPLFCIM----RQSTCL--DLKFDQAMMAFLD R_norvegicus_ENSRNOP00000054742 TISDDGPLGMINNFRLGCLPAVRVGWTEINAAWGQTALLLFSLSKMAGLQFQRYQLVPLGDHSYLKSLTADEV---------------LPLFSDG----NHSVFL--NNTFDCAMKAFLD S_cerevisiae_YPL120W KISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRK--ETKFDKSLETTLE C_elegans_T19E7.3.1 HIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIK-LRRNGID--------------METYALY----GQGTPLSGSSGIDPGIRRFLQ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000355231 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- P_troglodytes_ENSPTRP00000046569 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- M_mulatta_ENSMMUP00000034400 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- M_musculus_ENSMUSP00000040094 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- C_familiaris_ENSCAFP00000021764 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- B_taurus_ENSBTAP00000026531 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- R_norvegicus_ENSRNOP00000027868 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- E_caballus_ENSECAP00000016069 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- M_domestica_ENSMODP00000018835 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- P_pygmaeus_ENSPPYP00000009414 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- G_gallus_ENSGALP00000004697 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- A_carolinensis_ENSACAP00000013592 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- X_tropicalis_ENSXETP00000027611 CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- T_guttata_ENSTGUP00000002874 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- G_aculeatus_ENSGACP00000008498 CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R---------- G_gorilla_ENSGGOP00000001565 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- T_nigroviridis_ENSTNIP00000014523 CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R---------- T_rubripes_ENSTRUP00000034988 CVQQFKEE---------------------------VEKGDTGFCLPYSIRMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R---------- O_cuniculus_ENSOCUP00000013727 CVQQFKEE---------------------------VEKGETRFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- O_latipes_ENSORLP00000005780 CVQQFKEE---------------------------VEKGDTGFCLPY--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVTSQFYN----R---------- O_anatinus_ENSOANP00000019267 CVQQFKEE---------------------------VEKGNPELCLCD--RMDVEKGKIEDTGGSGGSYSIKTQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFYN----K---------- M_mulatta_ENSMMUP00000002276 CMQQFKEE---------------------------AEKGELGLCLPY--RIQVETGLMEDAGGRGECYSIRTHLNTQE-LWTKALKFLLINLKWSLIWVASRYQK--------------- A_aegypti_AAEL010427-PA CLQQFKEE---------------------------VVKKDPDFCLPY--RM--EKGKIEDS-ATGNSYSIKIQFNSEE-QWTKALKFLLTNLKWGLTWVSSQFTEEKPSA---------- P_troglodytes_ENSPTRP00000056655 CMQQFKEE---------------------------AEKGELGLSLPY--GIQVETGLMEDVGGRGECYSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK--------------- P_pygmaeus_ENSPPYP00000000063 CMQQFKEE---------------------------AEKGELGLCLPY--RIQVGTGLMEDVGGRGECYSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK--------------- A_gambiae_AGAP003858-PA CLQQFKEE---------------------------IVRRDPDFCLPY--LM--EKGKIEDA-STGSSFSIKIQFNSEE-QWTKALKYLLTNLKWVLTWVSSQFTEDK-QR---------- C_intestinalis_ENSCINP00000019537 CLQQFKEA---------------------------VE-GNSGFSLPY--RM--EKGKIEDTGGSGASYSIKMQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFTP----S---------- E_caballus_ENSECAP00000015556 CLQHFNKE---------------------------AKKGESGLCLPH--RIHVSKGLMEDPGGGGAFYSIRTHFNTEE-RWTKALKLMLVNFKWSLAWVSLRYRQ----K---------- D_melanogaster_FBpp0083975 CLTQFQKE---------------------------VEKRDTEFLLPY--KM--EKGKIIDP-STGNSYSIKIQFNSEE-QWTKALKFMLTNLKWGLAWVSSQFVS----P---------- O_cuniculus_ENSOCUP00000015004 CLQQFKEK---------------------------AEKGKQGLRLPY--RIRVEEGLLEDSTGSGECCALRSHLNTRE-QWTRALKFMLVNLKCSLAWASLRYQK--------------- G_gorilla_ENSGGOP00000007989 CMQQFKEE---------------------------AEKGELGLSLPY--GIQVETGLMEDVDGRGECCSIRTHLNTQE-LWTKALKFMLINFKWSLIWVASRYQK--------------- C_familiaris_ENSCAFP00000023183 CMQQFKEE---------------------------AEKGKWGLCLPC--RIHVKNGLMEDSGSTGEFYSIRTYLNTEE-QWTKALKLMLINLKCSLTWVSLRYQE--------------- R_norvegicus_ENSRNOP00000054742 CLQQFVEE---------------------------TEKDERYPCLPY--RIHPLEGVMEDIGDSGDCCPIRTHLNTEE-EWSRALKFMLADLKLIVAWAS-------------------- S_cerevisiae_YPL120W IISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPY--IM--NKDKI-------NGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTI C_elegans_T19E7.3.1 LLEFLLKE---------------------------LKDRNKNFKPPY--QIHADS--LVD---NGVKYNAVMTLNTDV-RWTRAMALMLTDLKAACAQCDALRSP----I---------- 610 === H_sapiens_ENSP00000355231 --- P_troglodytes_ENSPTRP00000046569 --- M_mulatta_ENSMMUP00000034400 --- M_musculus_ENSMUSP00000040094 --- C_familiaris_ENSCAFP00000021764 --- B_taurus_ENSBTAP00000026531 --- R_norvegicus_ENSRNOP00000027868 --- E_caballus_ENSECAP00000016069 --- M_domestica_ENSMODP00000018835 --- P_pygmaeus_ENSPPYP00000009414 --- G_gallus_ENSGALP00000004697 --- A_carolinensis_ENSACAP00000013592 --- X_tropicalis_ENSXETP00000027611 --- T_guttata_ENSTGUP00000002874 --- G_aculeatus_ENSGACP00000008498 --- G_gorilla_ENSGGOP00000001565 --- T_nigroviridis_ENSTNIP00000014523 --- T_rubripes_ENSTRUP00000034988 --- O_cuniculus_ENSOCUP00000013727 --- O_latipes_ENSORLP00000005780 --- O_anatinus_ENSOANP00000019267 --- M_mulatta_ENSMMUP00000002276 --- A_aegypti_AAEL010427-PA --- P_troglodytes_ENSPTRP00000056655 --- P_pygmaeus_ENSPPYP00000000063 --- A_gambiae_AGAP003858-PA --- C_intestinalis_ENSCINP00000019537 --- E_caballus_ENSECAP00000015556 --- D_melanogaster_FBpp0083975 --- O_cuniculus_ENSOCUP00000015004 --- G_gorilla_ENSGGOP00000007989 --- C_familiaris_ENSCAFP00000023183 --- R_norvegicus_ENSRNOP00000054742 --- S_cerevisiae_YPL120W SGN C_elegans_T19E7.3.1 ---