10        20        30        40        50        60        70        80        90       100       110       120
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            ----------------------------------------------------------------------------------------IETMKSKGLEPSGQPGVLSLKNPILTQSTDLQ
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 -MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLSSLK
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          -MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKTMEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           -MEKLCGYVPVHPDILSLKNRCLTMLSDIQPLEKIHGQRSVNPDILSLENRCLTLLPDLQPMEKIHGQRSVHPDILSSENRCLTLLPDLQSLEKLCGHMSSHPDVLSLENRCLATLPTVK
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              --KKPHGHVSAHPDILSLEKRCLAMLPDLQPMKKLHQHISAHSDILSLKNQCLATLPDLKTVEKPHGYVSAHPDILSLENRCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLK
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             -------------------------LPDLKTMEKPHGHVSAHPNILSLENRCLSTLPDLKTVEKPHGHVSSHPNVLSLENRCLATLPDLKTVEKPHGHVSAHPNVLSLENRCLATLPILK
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               MLEKPPGHVSTHSDILSLENRCLATLPDLKTLEKPPGHMSAHSDILSSENRCLATLPDLKTLEKPPGHVSAHSDILSLENRCLATLPDLKTLEKPPGHVSAHSDILSLENRCLATLTILK
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  130       140       150       160       170       180       190       200       210       220       230       240
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            STVSASHLLQPFQPSPLIEASLKGMDTSNHLLLEPAARKAQDFTLGHFTKWPKRTLKAKLAKRKSVRGSWMAQWIEEEEEE----EEQVEEAIPLYNLSLR-KEKE-SEELMLELVSRDS
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 STVSASPLFQSLQISHMTQADLYRVNNSNCLLSEPPSWRAQHFSKGLDLSTCPIALKS-ISATETAQEATLGRWFDSEEKK------GAETQMPSYSLSLG-EEEE-VEDLAVKLTSGDS
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          STVSASPLFQSLQISHMTQADLYRVNNSNCLLSQPPSWRAQHFSKGLDLSTCPIALKS-ISATETAQEATLGRWFDSEEKK------GAETQMPSYSLSLG-EEEE-VEDLAVKLTSGDS
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           RTVSSGPLLQCLHRSHTAQADLRDPNFRNCLFPEPPTIEAPCFLKELDLPTGPRALKS-MSATARVQEVALGQRCVSEGKELQEEKESAEVPMPLYSLSLGGEEEEVVGAPVLKLTSGDS
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              STVSASRLFQSLQISHMTQADLYCVNNSNCLLSEPPSWSAQHFSKGLDLSTCPTALKS-LSATGTVQEATLGRWFDSEEKK------GAETQMPSYSLSLGEEEEE-VEDLALKLTSGDS
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             STVSASALLQRLQTFHPVQADLCSLNTSNHLLSEPPTWRAQYLSEGLGLLTFPGALQS-ISATETVQEAAVGHWSSSEEKR-PGAEEWAEAPMPFYSLSLG-EEEE-VEELALKLTSGES
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               STVSISPLLQNLQISHLAQADLCSLNSSNHLLSEHPASRVQYLSEGRGLLTCPRVSKT-ISAPERVQEAVLGRWSSSGEKK-PEEKEWAEAQMPFYRLSLG-EEEE-VEELALKLTPGDS
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  250       260       270       280       290       300       310       320       330       340       350       360
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            DAQPENTDQVLQDKKMLLITKLCCALSSRANLLEAKDPTRNFLLQLCTDLALLEPEFILKASLYARQQLNIRDMAIMVLAIAAYLPACRPYLRRYFCAIVQLPSDWMQVAQYFQNLAESP
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 ESHPEPTDHVLQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          ESHPEPTDRVLQEKKMALLSLLCSTLVSEVNVNNTSDPTLAAIFEICRELALLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           DSHPETTDQILQEKKMALLTLLCSAMASSVNVKDASDPTRASIHEVCSALAPLEPEFILKASLYARQQLNLRDIANIVLAVAALLPACRPHVRRYYSAIVHLPSDWIQVAEFYQSLAEGD
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              ESHPEPTDQVLQEKKMALLSLLCSTLVSEVNMKDASDPTLAAIFENCRELAPLEPEFILKASLYARQQLNVRNVANKILAIAAFLPACRPHLRRYFCAIVQLPSDWIQVAELYQSLAEGD
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           --------HILQ---MELVSAVCCSLVRGPKFSDSCDETRVKLLALCEELSNLDPEFILKVALYTRQELNIRSTANFMLAVSAFLPACRPHLRRYFCASVQLPADWMEIPRLYQSLA-GQ
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             ESCPEPTDRALQEKKMTLMSLLCSTRASNVNMKDAADPTAASLFEICSELAPLEPEFILKASLYTRQQLNVRDVANRVLAIAAFLPVCRPYLRRYFCAIVQLPSDWIQVAEFYQSLAEGE
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               ESHPEPTEQVLQEVKMVLMSFLCSSLVANVNRNDAAYSTQAFLLKVCSEVARFEPEFVLKASLYTRQQLNVRDVANKVLAIAAFLPLCRPYLRRYFCAIVQLPSDWIQVARFYELLCREQ
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  370       380       390       400       410       420       430       440       450       460       470       480
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            DKKLVPMPACLRAAMTEKFTQFDEYQLAKYNLREHRAKKRRRRYRRPVSDFFPVS-SHRSNPLYL-GTKRAKQNRKFMRAYHEEPVKKKPSDFTLKKLIKRLHIRDPVQNVKALLGCRYP
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 KNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPGMEPPFS--HRCFPRYI-GFLREEQ-RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYP
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          KNKLVPLPACLRTAMTDKFAQFDEYQLAKYNPRKHRAKRHPHRPPRSPRMEPPFS--HRRFPRHI-GFLREEQ-RKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHKPAQHVQALLGYRYP
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           EKKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRSKTRSRQPPRPQRTKPPFSESGKCFPKSV-WPLKNEQ-ISFEAAYNAVSEKKRLPRFTLKKLVEQLHIHEPAQHVQALLGYRYP
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              ENKLVPLPACLRAAMTDKFAQFDEYQLAKYNPRKHRAKRHPRRPPRSPRMEPPFS--RRPFPRYI-VFLRDEQ-KKFEKAYDTVSEKKNPPRFTLKKLVQRLHIHEPAQHVQALLGYRYP
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           GEKLAPLPSCLRRVLTVKFQKFTEYQLAKYNTRRQRGKHSIRKPKLSRFLNFLFF---HIFPLVVDKGLKLLQ-KKFSTP--PTPKMKTKDRFSMKSLIQRLHISKPTHHVMGILGCKYP
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             ENKLVPLPSCLRAAMTDKFAQFDEYQLAKYNPRKHRAKSRPRRRPHPPKTEHPFSERQRYLPKCL-APLMDEQ-KKFEASYNVVPEKKKQPRFTLKKLVQRLHIKEPAQHVQALLGYRYP
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               EDCLAPLPACLRAAMRDKFSQFDEYQLAKYNPRKHRAKRRPRRPPRPPK-EHTFSETQTYLPRFI-WHIRGEQ-RMFETTYGSVSEKKTEQRFTLKKLVRRLHIHEPAQLVQALLGCRYP
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  490       500       510       520       530       540       550       560       570       580       590       600
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            SDLQSFSRSRLPGPWDSSRAGTRMKLPQPETWERVLSQQGNTASVWEGLIDSGKLPYMAMLRNLCSLLRVGISAKHHERILQLLERKESVIRSRQLPFRFLSAHTSISDLERQLKNSG-P
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNQALP
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDAIDALEAQLRNHALP
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           STLELFSRSHLPGPWDSSRAGQRMKLQRPETWERELSLRGNRASVWEELIDNGKLPFMAMLRNLCNLLRTGISAHHHELVLQRLQHEKSVIHSRQFPFRFLNAHDSLDRLEAQLRSKASP
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              SNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVWEELIENGKLPFMAMLRNLCNLLRVGISARHHELILQRLQHAKSVIHSRQFPFRFLNAHDSIDALEAQLRNQALP
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           KDLYSFSKSGLEGPWQSDLSGQKMKLKQPQTWDRELSLKGNTGLVWEKLLDSDQVPFMALLRNLRNMIRAGISRQHHNQVTSRLSSERAVIKSRMFPFRFLSAYKVIQDLENQCHVSGKP
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             SNLQAFSRSRLPGPWDSSRAGKRMKLSQPETWERELSLRGNKASVWEELIDNGKLPFMAMLRNLCNLLRVGISPRHHELVLQRLQHAKSVIHSRQFPFRFLNAHDSINDLEAQLKSKALP
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               SNLQAFSRSRLPGPWDSSRAGKRMKLARPETWERELSLRGNKATVWEELIDSGKLPFMAMLRNLRNLLRVGISARHHELVLQRLQHAKTVIHSRQFPFRFLNAHDSINDLEAQLEKKELP
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  610       620       630       640       650       660       670       680       690       700       710       720
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            VPCNVVIMRQLLERLEKKKKLPKPERKL---TNWDLRFAMMVPVLYEHFKREKQRLIQISHWKRDWEMMKRYQQALETAMNLSVQHNLPPLPGRTLIICSPYESQDKKKVKKNQN--PLT
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 FPSNITLMRRILTRNEKNRPRRRF---LCHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQGPPLN
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          FPSNITLMRRILTRNEKNRPRRRF---LYHLSRQQLRMAMRIPVLYEQLKREKLRVHKARQWKYDGEMLNRYRQALETAMNLSVKHSLPLLPGRTVLVYLIDANADRLCPKSNPQGPPLN
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           FPSNTTLMKRIMIRNSKKIKRPANPRYLCTLTQRQLRAAMAIPVMYEHLKREKLRLHKARQWTCDLELLERYRQALETAVNISVKHNLPPLPGRTLLVYLTDANANRLCPKSHLQGPPLN
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              FPSNTTLMRRILTRSDKNRPRRRF---LCHLSCQQLRTVMRVPVMYEKLKREKLRVHKARQWKYDGEMLNRYRQALETAVNLSVKHSLPLLPGRTILVYLTDANADRLCPKSNPQGPPLN
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           FPVNVRLIKNIVTSEAASI----PELKRYTWSRRQLRGCLAVPAIRQLLKRKKEALRKLRACKMDQAILQKYKKALESAVKISARYNITPLPGRTVILFYVSESMDKPCHGAK----DLK
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             FPSNTKLMRQIMIRNSKNIKRHAYQKKLCNPSRRELRAAMMVPLMYEQLKREKLKIHKSRQCKYDSETLARYRQALETAVNLSVKHSLPPLPGRTLLVYMTDAEADKLCPKNNPQGPPLN
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               FPSNTQLIKQIIIKNTKYGKKHAYSWQFRQPSRRELRTAMMIPVIYEQLKRKKMKIHKARQWKCDREMLARYRQALETAVNLSVKHSLPPLPGRTLLVYLTDASADRILPKSNPQGPPLN
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  730       740       750       760       770       780       790       800       810       820       830       840
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            HVLLLVAMLMARAEQAELLLCKRGTLKKAVTNPEEGILKTATELETQIQAF--HGEISESGHHPFVTYLLDMVTRRVLMDTVIFVGNTMKDFEFMTAKQFFWQRVNPKCLFVGVDLMGMD
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 YALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEF--DEN-DGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQ
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          YALLLIGMMITRAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKLQAQVQEF--DEN-DGWSLNTFGKYLLSLAGQRVPVDRVILLGQSMDDGMINVAKQLYWQRVNSKCLFVGILLRRVQ
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           YVLLLIGMMMARAEQTTVWLCGTGTVKTPVLTADEGILKTAIKLQAQVQEL--EEN-DEWPLETFEKYLLSLAVRRTPIDRVILFGQRMDTELLNVAKQIIWQHVNSKCLFVSVLLRKMQ
D_melanogaster_FBpp0085899                ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              YALLLIGMMITRAEQVDVMLCGGDTLKTAVLKAEEGILKTAIRLQAQVQEF--DEN-GEWSLNTFGKYLLSLAGQRVPADRVILFGQSMDEGMINVAKQLYWQHVNSKCLFVGVLLRRVQ
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           VGLLLSGMVRDTSESAQVVLFNDQTYILAEFNS-SSLLHNVSHLKKQAEDLKSQGRYSSRNKNVAKKYLMELLANRTKVDTLLLFRLSPPSAEFKSVLKQYRREVNTDCLCVTVVPENLQ
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             YVLLLIGMMIARAEHADLLLCGSGTLKTAVLKAEEGILKTAIELHAQVQEL--DGNYYEFSRDTFGKYLLSLAAQRVPVDRVILFGHIMNGSLINEAKQLFWQHVNSKCLFVGVCLRRIC
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               YVLLLIAMMMVRTEQVELLLCGGGIVKTAVIKAEEGILKTATELQAQVQKS--DES-CEQSLTTLGKHLLSLATQRVPVDRVIVFGQTTNEKLINAAKQLFWQHVNPKCLFVGVLL-RAS
A_aegypti_AAEL001276-PA                   ------------------------------------------------------------------------------------------------------------------------

                                                  850       860       870       880       890       900       910       920       930       940       950       960
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      --------------------------------------------MFRGKGQQQVSSTDNIKAMMTAAIGNKLEKRLPLVSTIFVVGNDEEEFNIERRTLWQDVLPDLQNLAFQSNFDLEF
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            SCSL--STNPNDVILTGCTDGILKFISERGMSRLLEHVGQMDKIFKIPPPRGEAQTLPDRPLEEREPSPLTPAPQHSWRSVRIFISSTFRDMHGERDLLLRSVLPALQAQAAPHHISVRG
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 YLST--DLNPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          YLST--DLNPNDVTLSGCTDAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLASISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           YIDPYFLSAPAKVSIGSCSCMSLLFIAEHGASRLLEHVGQLDKIFKIPPPPGKTKVSPLRPLEENNPGPFVPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQARAFPHRISLHA
D_melanogaster_FBpp0085899                ----------------------------------------------------MAAPIDESVLNALRGVTSAHTRLPKPLLIKIYVASLKQEFNQERRMLLELVGPELQSLYDDRQIELEF
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              YLSP--DLNPNDVTLSGCTDGILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPISQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHG
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           REES--FDQCNDVVLHGFTEQVLRYVSERGTVRLLDHVAKVNERFQVPEDPDSVK-RSHDFGHEVIPSPIT----QRWRSIRIFISSTFRDMHSERNLIIGQVIPELRSRAACHYLSVEE
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             YTFS--DSNPNDVTLLGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGAPSLRPLEENTPSPLASISQSRWRKIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHA
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   ----------------------------------------------------MATAIEEAVFNALRGHHNEHTKLPSPRIIKIYIASLKDDFKEERRLLLEIIGPDLQALYDDRQLEIEI
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               YLCT--DLNPNDVTLSGCTDGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEENTPSPLAPVSQLGWRSIRLFISSTFRDMHGERDLLLRSLLPALQARVAPYRISLHA
A_aegypti_AAEL001276-PA                   ----------------------------------------------------MAAIIEEAVFNALRGHHNEKTKLPSPRIIKIYVASLKEDFKEERRLLLEVIGPDLQSVYDDRQIEVEI

                                                  970       980       990      1000      1010      1020      1030      1040      1050      1060      1070      1080
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH
P_troglodytes_ENSPTRP00000042795          --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH
P_pygmaeus_ENSPPYP00000005543             --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH
M_mulatta_ENSMMUP00000038848              --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMNH
E_caballus_ENSECAP00000022364             -------------------------------------------------------------------------------------------RMDAKARNCLLQHREALEKDIKTSYIMDY
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------GKMDAKARNCLLQHREALERDIKTSYIMDH
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------GRMDAKARNCLLQYREALEKDIKTSYIMDR
M_musculus_ENSMUSP00000020157             --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------GRMDARARNCLLKHMEALEKDIKTSYIMDH
M_domestica_ENSMODP00000009538            -------------------------------------------------------------------------------------------RMDAKARNCLLQHKEALERDIKTSYLMDH
R_norvegicus_ENSRNOP00000010869           --------------------------------------------------------------------------------------------MDAKARNCLLQHKEALEKDIKTSYIMDH
T_guttata_ENSTGUP00000009081              -------------------------------------------------------------------------------------------NMDVKSRNYLLMNRQALENDIKTSYIMDR
G_gallus_ENSGALP00000037436               --------------------------------------------------------------------------------------------MDENSRMCLITNRQALEKDIKTSYIMDH
A_carolinensis_ENSACAP00000012965         -------------------------------------------------------------------------------------------TMDLTARSHLLQNREALERDIKTSYVIDH
G_gorilla_ENSGGOP00000008216              --------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDH
X_tropicalis_ENSXETP00000014654           --------------------------------------------------------------------------------------------MDEKARSLLLQNRTALVRDIRTAYIMDH
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                --------------------------------------------------------------------------------------------MEERARSRLLRSKATLEQDIKASYLMDH
T_rubripes_ENSTRUP00000033561             --------------------------------------------------------------------------------------------LEEGARSSLLRFRHQLEQDIKPSYLMDH
T_nigroviridis_ENSTNIP00000013938         --------------------------------------------------------------------------------------------LEERARSCLLRFRHQLEQDIKPSYLMDH
G_aculeatus_ENSGACP00000026214            --------------------------------------------------------------------------------------------LEEGARSCLMRFRHRLEDDIKPPYLMDH
O_latipes_ENSORLP00000019346              --------------------------------------------------------------------------------------------LDERARACLLKSRHKLEEIMKPAYLMDH
C_elegans_Y45F10B.10                      CDVPLENGELTNSVAEHVLQMWKD-----------NPRSWIVLLLGNRYGNVSVPTSLRKEEYESIRSSIFEENGNVRVFEKAYTINRNGAVEEYRLVPSAIKDKKQLAEIIKALQAGAK
C_intestinalis_ENSCINP00000010464         -----------------------------------------------------------------------------------------------------MGITKQYLRYLSVAQF---
O_latipes_ENSORLP00000010395              -----------------------------------------------------------------------------------------------------MGLTKQYLRYAPSAVF---
T_nigroviridis_ENSTNIP00000007980         -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
T_guttata_ENSTGUP00000006840              -------------------------------------------------------------------------------------------------------FPSSYAATRKIEPF---
T_nigroviridis_ENSTNIP00000004057         -----------------------------------------------------------------------------------------------NMASSHLHFKTNYAVSSKIEPF---
M_domestica_ENSMODP00000008927            IDLRWGVTEEEIQKDRQLELCLGE----------VENSQLFVGILGSRYGYVPPNSNLPDHPHFHW----------------VKDYPPGRSVTEMEVMQFLNRGSHQQGVSPALIYLRDS
D_rerio_ENSDARP00000023281                -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
G_gallus_ENSGALP00000008904               --------------------------------------------------------------------------------------------MAATAAGSVVRFKSNYAVSRRIEPF---
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------MANTNLQFKTNYAVESKIEPF---
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------MKKNEYEVQNQYKAF---
M_musculus_ENSMUSP00000060613             -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
H_sapiens_ENSP00000262715                 IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYIPPSYNLPDHPHFHW----------------AQQYPSGRSVTEMEVMQFLNRNQRLQPSAQALIYFRDS
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------MANPHLHFKTNYAVSSKIEPF---
C_intestinalis_ENSCINP00000019387         -----------------------------------------------------------------------------------------------------LQLRTKYDLIKKWEPF---
G_gallus_ENSGALP00000023833               -----------------------------------------------------------------------------------------------------MGLTRQYLRYAPAALF---
P_troglodytes_ENSPTRP00000010340          IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYVPPSYNLPDHPHFHW----------------AQQYPSGRSVTEMEVMQFLNRNQCLQPSAQALIYFRDS
T_guttata_ENSTGUP00000013749              -----------------------------------------------------------------------------------------------------MGLTRQYLRYEPAALF---
T_rubripes_ENSTRUP00000006345             -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
H_sapiens_ENSP00000308179                 -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
R_norvegicus_ENSRNOP00000012235           IDLRWGITEEETRRNRQLEVCLGE----------VENSQLFVGILGSRYGYTPPSYDLPDHPHFHW----------------TQRYPSGRSVTEMEVMQFLNRGQRSEPSDQALIYFRDP
D_melanogaster_FBpp0085899                VDMHFGTGDLEVHQLERDPYLIHDYLHEIDTCHAHTKSVFFMVLVGDGIGRQLLPTKIDEDIFSAVLADQQTSADHEAMLVKWYERDASQTQRQLKQDYRLMNVDAWLAESQRMQSFLEQ
P_troglodytes_ENSPTRP00000001997          -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
M_mulatta_ENSMMUP00000011166              -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
M_domestica_ENSMODP00000006461            -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
P_pygmaeus_ENSPPYP00000001131             -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
M_mulatta_ENSMMUP00000021364              IDLRWGVTEEETRRNRQLEVCLGE----------VENAQLFVGILGSRYGYIPPSYNLPDHPHFHW----------------AQQYPSGRSVTEMEVMQFLNRSQRLQPSAQALIYFRDS
B_taurus_ENSBTAP00000026561               -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
R_norvegicus_ENSRNOP00000026726           -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
A_gambiae_AGAP009615-PA                   --------------------------------------------------------------------------------------------------SPLICGSRRYEVKQQYKAF---
B_taurus_ENSBTAP00000027147               ---------------------------------------------------------------------GDAISASPRCGMAPGSPSRGGTGDMAEVAAGVGRFKSNYAVERKIEPF---
X_tropicalis_ENSXETP00000035244           VDLRWGITEEETRKDRQLHLCLSE----------VCRSQIFIGILGERYGHVPKTYSLPLLSEYEW----------------EGTLASNEDEEELAQEGFQERQTSLSCARRYLLYL---
A_aegypti_AAEL004364-PA                   -----------------------------------------------------------------------------------------------------MGLTKQYLAFKPVANF---
O_anatinus_ENSOANP00000004860             -----------------------------------------------------------------------------------------------------MGLTRQYLRYVAGAVF---
E_caballus_ENSECAP00000005446             -----------------------------------------------------------------------------------------------------MGLTKQYLRYVASAVF---
S_cerevisiae_YLR222C                      -----------------------------------------------------------------------------------------------------MDLKTSY-KGISLNPI---
E_caballus_ENSECAP00000009299             IDLRWGVTEEETRRNRQLEVCLGE----------VENSELFVGILGSRYGYIPPNYNLPDHPHFRW----------------AQQYPSGRSVTEMEVMQFLDRSLRLQPSAQALIYFRDS
X_tropicalis_ENSXETP00000021860           -----------------------------------------------------------------------------------------------------MGLTKQYLRYAASAVF---
A_gambiae_AGAP004827-PA                   VDIHFGTGSDGLTIVDLDPYVLDDHLEEIETCHCVSKSVFLIVLLGSRLGNFLLPTKLDSSIFTAI--SKLSTDDEVQCLRKWYSTTCPKTNIHQTEDTQTLDRAEWVTEAQQLRELLER
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------ADLDQADRGILSGWGWSHGQGPGDGAGTVEQGAEVGWASNVYAVQRRIEPF---
X_tropicalis_ENSXETP00000015707           --------------------------------------------------------------------------------------------YPDPCFG--LFAFSSYAVTRKIEAF---
M_mulatta_ENSMMUP00000010429              ---------------------------------------------------------------------------------------------MAETAAGVGRFKANYAVERKIEPF---
B_taurus_ENSBTAP00000001564               IDLRWGITEEETRQNRQLEVCLGE----------VENSQLFVGILGSRYGYVPPNYSLPDHPHFCW----------------AQQYPAGRSVTEMEVMQFLNRGLRLQPSAQPLLYFRDS
A_aegypti_AAEL001276-PA                   VDIHFGTGS-GCTVVDLDPYVLEDHLYEIETCHRVSKSVFLIVLLGSRLGNFLLPTKLDSEIFTAI--NKRSTADECECLRKWYQEDAAAGCYVLRTQFRTKERQEWITESRQLSDILEN

                                                 1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 MISDGFLTISEEEK---------------------------------------------VRNEPT-------------------------------QQQRAAMLIKMILKKDN-------
P_troglodytes_ENSPTRP00000042795          MISDGFLTISEEEK---------------------------------------------VRNEPT-------------------------------QQQRAAMLIKMILKKDN-------
P_pygmaeus_ENSPPYP00000005543             MISDGFLTISEEEK---------------------------------------------VRNEPT-------------------------------QQQRAAMLIKMILKKDN-------
M_mulatta_ENSMMUP00000038848              MIRDGFLTISEKEK---------------------------------------------VKNEPT-------------------------------HHQRAAMLIKMILKKDN-------
E_caballus_ENSECAP00000022364             MISDGVLTVSEEEK---------------------------------------------VKNEPT-------------------------------RQQKAAMLIKMILKKDN-------
B_taurus_ENSBTAP00000028867               MISNGVLTVSEEEK---------------------------------------------VKNEPT-------------------------------QRQRAAMLIKMILKKDN-------
C_familiaris_ENSCAFP00000009806           MINDGVLTISEEEK---------------------------------------------VKNEPT-------------------------------QQQRAALLIKTILKKDN-------
M_musculus_ENSMUSP00000020157             MISNGVLSVIEEEK---------------------------------------------VKSQAT-------------------------------QYQRAAALIKMILNKDN-------
O_anatinus_ENSOANP00000008896             MISDRTLTLSEEEK---------------------------------------------VRNQGT-------------------------------QEERAAMLIKLILEKDN-------
M_domestica_ENSMODP00000009538            MISDQVLSLSEEEK---------------------------------------------IRNEPT-------------------------------QKKRAALLITVLLGKDN-------
R_norvegicus_ENSRNOP00000010869           MISNGVLTVVEEEK---------------------------------------------VKSQAT-------------------------------QYQRAAALIKMILNKDN-------
T_guttata_ENSTGUP00000009081              MISDEVLTLQEEER---------------------------------------------VKQQNT-------------------------------QKERAAMLINIILTKDN-------
G_gallus_ENSGALP00000037436               MVADQVLTLQEEEK---------------------------------------------VKQQNT-------------------------------QKERAAMLINTLLTKDN-------
A_carolinensis_ENSACAP00000012965         MIADGALTPQEEAE---------------------------------------------VKAVTT-------------------------------QRDRAAKLIKTILKKDD-------
G_gorilla_ENSGGOP00000008216              MISDGFLTISEEEK---------------------------------------------VRNEPT-------------------------------QQQRAAMLIKMILKKDN-------
X_tropicalis_ENSXETP00000014654           MISDQVITPEEEAQ---------------------------------------------VKSQRT-------------------------------QMDKANFLINLILGKSN-------
O_cuniculus_ENSOCUP00000010200            ------------EE---------------------------------------------V-NECT-------------------------------QRQRAAMLIKMILKKDN-------
D_rerio_ENSDARP00000008347                MISDGVLTNDEEAK---------------------------------------------VLSKAT-------------------------------RKEQAVALLETLLRKDN-------
T_rubripes_ENSTRUP00000033561             MISDGVLSVDEEEK---------------------------------------------IRTLAT-------------------------------RKDQAVALLDLLLRKDN-------
T_nigroviridis_ENSTNIP00000013938         MVSDGVLSIDEEDR---------------------------------------------IRTLPT-------------------------------RRDQAVALLELLLKKDN-------
G_aculeatus_ENSGACP00000026214            MVTDGVLTGDEEER---------------------------------------------IKNQPS-------------------------------RKDQAAALLALLLMKDN-------
O_latipes_ENSORLP00000019346              MISDEAITVEEEDM---------------------------------------------IANQNT-------------------------------KREQAAALVDLLLKKDN-------
C_elegans_Y45F10B.10                      AAHEEGSINQVHEQRQNRFFSSPLETFVRSILQVSPCRCLFLLRKFDQLVADPNSPNAFLETNDQ-------------------------------NSRKIEDLKNEITLKMNDRVMTHV
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            SFLSSVPDGWKIDF---------------------------------------------ASESDE-------------------------------AAERISDLKSYLDKQEGVTCHRYS
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 SFLSSVPDAWKSDF---------------------------------------------VSESEE-------------------------------AARRISELKSYLSRQKGITCRRYP
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          SFLSSVPDAWKSDF---------------------------------------------VSESEE-------------------------------AACRISELKSYLSRQKGITCRRYP
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           GFLSSVPDVWKPDF---------------------------------------------ISESEE-------------------------------AAHRVSELKRFLQEQKEVTCRRYS
D_melanogaster_FBpp0085899                AFQSLLQGSGASGRS---------------------PDFMERVQLLRRTQIEREVSQAMALTSEKILAVFRERAAQCSKGDVEAAE----------RLRKIKDELTMNLSTDNHTTLVVP
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              SFLSSVPDAWKSDF---------------------------------------------VSESEE-------------------------------AACRISELKSCLSRQKGITCRRYP
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           -LFSSIPSKWVSDF---------------------------------------------GAESAE-------------------------------AEMKMSSLKSRLTEHSSAATYRYS
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             SFLRSVPDAWKSDF---------------------------------------------TSESEE-------------------------------AAHRISELKSSLNRQKGITCRRYA
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   KIDEVLRAAETKETSAGDG--------------LDGEQFCDNLKRLKTRAIAREIEKGLACSSGRILTLFRHWKNQPENDSTELEEDGHLGSNTGTEVKQVETNLIEALPASNHQTLTVD
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               SFLSSVPDAWKSDF---------------------------------------------ISESEE-------------------------------AAHRISELKSYLSRQEGITCRRYR
A_aegypti_AAEL001276-PA                   KINEILKTFPDGGEEGGGGGGSEEVVGAGGISLIDRKRFCDNLKRLKIRALELEIQKGLACSKENMLAIFRQWDAENGN-----------GPSNESRVEQIKSSLQESLPAENLETLTAP

                                                 1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM
P_troglodytes_ENSPTRP00000042795          ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM
P_pygmaeus_ENSPPYP00000005543             ---------D---SY--ISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM
M_mulatta_ENSMMUP00000038848              ---------D---SY--ISFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM
E_caballus_ENSECAP00000022364             ---------Y---CY--ISFYKALLQEGYKDLAALLHGGIPV--LSSSN-GKDSLVGVTSY-------------VKTVLCEGGVPQRPVVFVTRKKLVHAIRQKLLKLDGEPGWVTIYGM
B_taurus_ENSBTAP00000028867               ---------H---SY--ISFYNALLHEGYKDLAALLHGGIPV--ISSSD-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLNGEPGWVTIYGM
C_familiaris_ENSCAFP00000009806           ---------Y---SY--ISFYNALIHEGYKDLAALLHSGIPV--ISSSNGGKDSVGGITSH-------------VKTVLCEGGVPQRPVVFVTRKKLVNAIRQNLFKLSDEPGWVVIYGM
M_musculus_ENSMUSP00000020157             ---------C---AY--ISFYNALLHEGYKDLAALLQSGLPL--VSSSS-GKDTDGGITSF-------------VRTVLCEGGVPQRPVIFVTRKKLVHAIQQKLWKLNGEPGWVTIYGM
O_anatinus_ENSOANP00000008896             ---------F---SY--ISFYNALLHEGYRDLAALLQDGIPF--TASPK-GNDSLDGVTSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNEIQQKLYRLNDEPGWVTVYGM
M_domestica_ENSMODP00000009538            ---------N---SY--ISFYNALLHEGYKDLAFLLQKGLPL---SSYN-GKDPVDGVTSY-------------VKTVLCEGGVPQRPVVFVTRKKLVKSIQEKLYKLNDEPGWVTVYGM
R_norvegicus_ENSRNOP00000010869           ---------Y---AY--ISFYNALLHEGYKDLAGLLHSGLPL--VSSSS-GKDTDGGNTSF-------------VRTVLCEGGVPQRPVIFVTRKKLVSAIQQKLWKLNGEPGWVTIYGM
T_guttata_ENSTGUP00000009081              ---------N---SY--RSFYNALLHEGYRDLAALLQDGIPA--VSSGN-RKSSMDGMTSY-------------VKTILCEGGVPQRPVVFVTRPKLVDAIKKKLYCLGSDPGWVTVYGM
G_gallus_ENSGALP00000037436               ---------N---AY--RSFYNALLHEGYRDLAALLQDGIPA--FSSKN-GKNAMDERTSY-------------VKTALCEGGVPQRPVVFVSRPKLVDDIKQKLRSLGSDPGWVTVYGM
A_carolinensis_ENSACAP00000012965         ---------H---AY--ISFYNALVHEGYKDLAALLQDGIPI--ISPRN-GNKSTDGVTSY-------------VKTILCEGGVPQRPVVFATRPELTKRIQRKLYKLKSDPGWVVIYGM
G_gorilla_ENSGGOP00000008216              ---------D---SY--VSFYNALLHEGYKDLAALLHDGIPV--VSSSS-GKDSVSGITSY-------------VRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGM
X_tropicalis_ENSXETP00000014654           ---------Q---AY--VSFYNALLHEGYKDLAVLLKEAANA--ELSDS-TKSSSNGITSY-------------VKTVLCEGAVPQRPVVFVTRLKLVSKIQQSLYKLSVESGWVTVYGM
O_cuniculus_ENSOCUP00000010200            ---------N---SY--ISFYNALLYEGYKDLAALLHGGIPV--VSGSS-GKDSVGGITSY-------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
D_rerio_ENSDARP00000008347                ---------R---AY--ISFYNALIRESYGDLASLLHSDLPL--LSPEG-EKSFADGVSPS-------------VQAILSVGGVPQRPVVFVSRPPLLNLIREMLYRLRDTPGWVTVFGM
T_rubripes_ENSTRUP00000033561             ---------R---TY--ISFYNSLVKETYDDLATLLHEYLPR--LSPGA-TKNASDGCTPY-------------VQTVLSEGGVPQRPVVFVSRPELVNQIREKLYRLQKEPGWVTVFGM
T_nigroviridis_ENSTNIP00000013938         ---------R---AY--ISFYNSLVKVAYNDLATLLFEALPR----------SASDGCTPYGNRLITSFAVCPTVQTVLSEGGVPQRPVVFVGRPELVNQIREKLYRLQKGSGWVTVFGM
G_aculeatus_ENSGACP00000026214            ---------R---AY--ISFYNAMVQEGYNDLANLLHRDLPL--GLPEG-LKRSTDCCTPY-------------VQTVLSEGGVPQRPVVFVSRPELVNRVREKLYRLQKEPGWVTVFGM
O_latipes_ENSORLP00000019346              ---------Y---SF--RSFYNALLKEEYDELANLLKEDLPLTQFTSSS-QCPGEKCLGAV-------------VQTVLSEGGVPPRPEAFVHRPKEENEIREKLYKLQKQPGWVTVFGM
C_elegans_Y45F10B.10                      LRPESTDINYFFNSRDGDKYREKIARQFNEKLKNHLADINPPVRPEPPKSPMVLA-------------------ANEARTHQEFLENQLALGNLKRDYDKRLDELASVKVNRGVFLIQGT
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            CAWGGVAAGR---PY--VKGLEEFGQMVLQHVWELLQRLYVQPESSLEKTESAQNDDT----------------VQSAFQQLQHPPSPARPSLLKDIVQQLQQR------SGSLCLVTGE
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSPARPRLLQDTVQRLMLP------HGRLSLVTGQ
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSPARPRLLQDTVQQLMLH------HGRLSLVTGQ
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           CEWGGVAAGR---PY--TGGLEEFGQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDL----------------IQASFQQLKSPPSPARPRLLQDTVQQLMLP------HGRLSLVIGQ
D_melanogaster_FBpp0085899                GSAASEAIDPDNEDH--ESYLSKFKNKVTDKLRLLIEAHITNDPDVIKGRKKTVQEIFHEH------------ATHLRILREHTDSDALVESRVPQQLRQNLMANFRNGSRHAPYFLCGA
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNTIQKLYLQPGALLEQPVSIPDDDL----------------VQATFQQLQKPPSTARPRLLQDTVQQLMLH------HGRLSLVTGQ
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           CQWGGELQGK---PH--LTRLQNFGIRVLEDIWQAIERDYIKEGTLASNE---DEEEL----------------AQEGFQERQTSLSCARSKLVLSTCSQIQERTHASPTNGRLFLVCGD
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWNMIQKLYLQPEAQLEQPVSVPDDDL----------------VQATFQQLRKPLSSARPRLLQDMVQQLMLH------RGRLSLVTGQ
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   --WAENGIDPELECH--DLYLTSFKNKIFEMMKASIDQDLAKDPNGGKGRKKTVQEIFHEH------------STHLMYLNEHLSANKYISSKVPERIKQNVQMNFRSGSRHPPYFIHGG
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               CEWGGVAAGR---PY--VGGLEEFGQLVLQDVWSMIQKLYLQPGAQPEQPVPIPDDDL----------------VQATFQQLKKPRSPARPRLLQDTVRQLMQH------QGRLSLVTGQ
A_aegypti_AAEL001276-PA                   --WTEGGIDPELDSH--ESYLNDFKELMYDKLKNAIDQSLAKDPNGGKGRKKTVQEIFYEH------------STHLMYLNEHLNASKYISSKIPDRIRQNVQQNYRSGSRHPPYFIYGG

                                                 1330      1340      1350      1360      1370      1380      1390      1400      1410      1420      1430      1440
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDSQCQILLTTRDK
P_troglodytes_ENSPTRP00000042795          AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK
P_pygmaeus_ENSPPYP00000005543             AGCGKSVLAAEAVRDHSLLE-GCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK
M_mulatta_ENSMMUP00000038848              AGCGKSVLAAEAVRDHSLLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDSWVLKAFDNQCQILLTTRDK
E_caballus_ENSECAP00000022364             AGCGKSVLAAEAVRDHTLLE-GCFPGGVHW-LSVGKQDKSGLLMKLQNLCTRLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDR
B_taurus_ENSBTAP00000028867               AGCGKSVLAAEAVRDHSFLE-DCFPGGVHW-VSVGKQDKSGLLMKLQNLCARLDQ--DESFSQRLP-LNIEEAKDRLRILMLRKH-P--RSLLILDDIWDPWVLKAFDNQCQILLTTRDK
C_familiaris_ENSCAFP00000009806           AGCGKSVLAAEAVRDHFFLDVGCFPGGVHW-VSVGKQDKAGLLMKLQNLCTRLDQ--DENFSQRPP-LNIEEAKDRLRLLMLRKH-PRIRSLLILDDIWDSWILKAFDNQCQILLTTRDK
M_musculus_ENSMUSP00000020157             AGCGKSVLAAEAVRDHSLLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCMRLDQ--EESFSQRLP-LNIEEAKDRLRVLMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK
O_anatinus_ENSOANP00000008896             AGCGKSVLAAEALRDHRLLV-DCFPGGVHW-ISIGKQDKAGLLMKLQNLCMRFDQ--GSNFSQRPP-LNIEEAKDRLRVLMLRKY-P--RSLLILDDVWDSWVLKAFDIQCQVLLTSRDK
M_domestica_ENSMODP00000009538            AGCGKSVLAAEAVRDHNLLK-TCFPEGVHW-VSVGQQDKSGLLMKLQNLCTRLDQ--DGAFSQRLP-LNLEEAKDRLRFLMLRKY-P--RSLLILDDIWDSWVLKAFDSHHQILLTSRDK
R_norvegicus_ENSRNOP00000010869           AGCGKSVLAAEAVRDHALLE-GCFSGGVHW-VSIGKQDKSGLLMKLQNLCTRLGQ--EESFSQRLP-LNIEEAKDRLRVLMLRKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK
T_guttata_ENSTGUP00000009081              AGCGKTVLTAEALRDPQLLE-DYFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DSTLSQRPP-LNIEEAKDRLRLLMLRKY-P--RSLLVLDDIWDSWVLKAFDNQCQVLITSRDR
G_gallus_ENSGALP00000037436               AGCGKTVLTAEALRDHQLLR-GCFPGGVHW-ISVGKQDKAGLLIKLQNLCSRLEH--DSTLPQRPP-LNIEEAKDRLRLLMLRKYQS--RSLLVLDDIWDSWVLKAFDNQCQVLITSRDR
A_carolinensis_ENSACAP00000012965         AGCGKTVLAADALRDHNLLK-DCFPGGVHW-VSIGKQDKSGLLIKLQNLCLRLDQ--DVTYLQRPP-LNIEEAKDRLRVLLFRKY-P--RSLLVLDDIWDSWVLKAFDSHFQILLTSRDR
G_gorilla_ENSGGOP00000008216              AGCGKSVLAAEAVRDHSLLE-XXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXX-XXXXXXXXXXXXXXXXXX-X--XSLLILDDVWDSWVLKAFDNQCQILLTTRDK
X_tropicalis_ENSXETP00000014654           AGCGKTVLAAEALRDHKILN-ECFPGGVHW-VSVGRQDKAGLLMKLQNLCTRLDQ--EAKYSQRPP-LNAEEARERLRLMVNRMY-P--RCLIVLDDVWDSWVLKAFDIQCRVLITSRDK
O_cuniculus_ENSOCUP00000010200            XXXXXXXXXXXXXXXXXXXX-XCFPGGVHW-VSVGQQDKAKLLMKLQNLCSRLDQ--DESFFQRLP-LNIEEAKDRLRILMLHKH-P--RSLLILDDVWDPWVLKAFDNQCQILLTTRDK
D_rerio_ENSDARP00000008347                AGSGKSVMAAEVVRDRSLIK-ECFPDGVHW-LSVGQCERADLLVRMQSLCFRLEQCQSSDTSQRPP-STVEEAKERLRFLMLRRF-P--RSLLILDDVWDSSSLRSFDIQCRVLLTTRNR
T_rubripes_ENSTRUP00000033561             AGSGKSVLAAEAVRHHSLIE-ECFPGGIHW-LSIGQLDKPDLLVKIQALCFRLEQGLDSQSLHRPP-NSLDEAKERLRYLMLRRH-P--RSLLILDDVWDSMVLKTFDIHARILLTTRNR
T_nigroviridis_ENSTNIP00000013938         AGSGKSVLAAEAVRHHSLIE-ECFPGGINW-LSIGQLDKPDLLVKIQSLCFRLEQS-DSQSLHRPP-NSLDEAKERLRHLMLRRY-P--RSLLILDDVWDITVLKTFDIHCRILLTTRNR
G_aculeatus_ENSGACP00000026214            AGSGKSVLAAEAARHHGLIE-DCFPGGIHW-LSIGQLDKPDLLVKIQSLCFRLEQSLDSHPLHRPP-NSLDEAKERLRFLMLRRH-P--RSLLILDDIWDSTVLKAFDLHCRILFTTRNR
O_latipes_ENSORLP00000019346              AGSGKSVLASEAVRHKELIE-ECFPEGIHW-VSIGRLDKPDLLAKIQTLCFRLEQNLDSQQFHRPP-STLDEAKERLRFLMIRKY-T--RTLLILDDVWDSTVLKAVDIHCRILLTTRNR
C_elegans_Y45F10B.10                      DLCGKTQALCRLYHKIS----DKDAYKVIF-FTNLTYSSNFAHEAWRTICLNICSISNIDPKEVLEHFKLGGILKSLEELVQKADKP------VCIFIDDVHLLKFGHLLSQI--GRRTE
C_intestinalis_ENSCINP00000010464         -------------------------------GVLGSARCNVEYLSMR-------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              -------------------------------GVIGSQKANIAYVTLRG------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         -------------------------------GVIGSQKANVAYVTLRG------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              -------------------------------YKGGRIQI---------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         -------------------------------YKGGRVQI---------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            PGQGKTAFLSSLVSALQAPFGATRSSQVFFHFAGARPDQSYILTLLRRLCTYLRHQLQHS-KPFPT-TYRGLVWELHT-LLPKSAQTLRSGQTLVLVIDGADQL--GDQTGRLISDWIPK
D_rerio_ENSDARP00000023281                -------------------------------GVIGSQKANIAFVTLRG------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               -------------------------------YKGGRVQV---------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            -------------------------------YKGGKVQI---------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   -------------------------------YTGGTVQW---------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             -------------------------------GLIGSQKGNIVFVTLR-------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 SGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP-GALPS-TYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRL--VDQNGQLISDWIPK
T_rubripes_ENSTRUP00000017221             -------------------------------YKGGKVQI---------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         -------------------------------FTGGRVEV---------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               -------------------------------GLVGSARGNPAFVTLR-------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          SGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP-GALPS-TYQSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRL--VDQNGQLISDWIPK
T_guttata_ENSTGUP00000013749              -------------------------------GLVASARAGVAFVALR-------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             -------------------------------GVIGSQKANIAYVTLRG------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 -------------------------------GVIGSQKGNIVFVTLR-------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           AGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCTHLHQKLGEP-SALPS-TYRCLVWELQQKLLLKSAQWLQPGQTLVLIIDGADKL--VDHNGQLISDWIPK
D_melanogaster_FBpp0085899                DGSGKSAILCHLYGQVGSWFGSTRVHRVIR-FAKATPRSAYNLELLRVICQQISIIFNIPEGYLPKDASFDPLYINTWFQNLLRRVEDMGNDVLFLFIDDLHLLNPLDCDIVTALSWLPT
P_troglodytes_ENSPTRP00000001997          -------------------------------GVIGSQKGNIVFVTLR-------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              -------------------------------GVIGSQKGNIVFVTLR-------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            -------------------------------GLIGSQKGNIVFVTLR-------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             -------------------------------GVIGSQKGNIVFVTLR-------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              SGQGKTAFLASLVSALQAPDGAKVAPLVFFHFSGARPDQGLALTLLRRLCTYLRGQLKEP-GALPN-TYRSLVWELQQRLLPKSAESLHPGQTLVLIIDGADRL--VDQNGQLISDWIPK
B_taurus_ENSBTAP00000026561               -------------------------------GLIGSQKGNIVFVTLR-------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           -------------------------------GLIGSQKGNIVFVTLR-------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   -------------------------------YTGGTIVW---------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               -------------------------------YKGGKVQL---------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           RSQGKTIFMADLVKQLR----SSASTTVIYHFMGATPGAHEVEKMLTRICKQLSQGLNRE-CCNFT-SYRALLSEFHD-LLRLTSHSLRRNNTLTLLIDGADLL--CGRAGETTSEWIPE
A_aegypti_AAEL004364-PA                   -------------------------------NIIASGRANVAFVSVG-------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             -------------------------------GLVGSQKGNAVFVTLR-------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             -------------------------------GLIGSQKGNIVFVTLR-------------------------------------------------------------------------
S_cerevisiae_YLR222C                      -------------------------------YAGSSAVATV-------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             SGQGKTAFLASLVSALQAPDGVKVAPLVFFHFSGARPDQGLALTLLRRLCAYLHSQLQEP-SALPS-TYRGLVWHLQQRLLPKSAQSLQSGQTLVLIVDGADRL--VDQHGELISDWIPK
X_tropicalis_ENSXETP00000021860           -------------------------------GLIANQKANVAFITLR-------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   HGSGKSTLLSRIYTELTGWFEHTKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIPEGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDIVAALSWLPI
M_domestica_ENSMODP00000027702            -------------------------------YKGGKVQA---------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           -------------------------------YKGGKVQI---------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              -------------------------------YKGGKAQL---------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               SGQGKTAFLASLVSALQAPDGATVAPLVFFHFSGARPDHSLALTLLRRLCAYLHSQLEEP-SALPS-TYRGLVWELQQRLLPKSAQSLRTGQPLVLIVDGADRL--VDQRGQLISDWIPK
A_aegypti_AAEL001276-PA                   HGSGKSTLLSHIYTELTGWFEHIKVHRVIR-YASATPRSAYNLELLRVICQQLAIILNIPEGYLPKDASFDPLYINNWFQNLLKHCEDLHNEILFLFIDDLHRLNPLDCDIVAALSWLPI

                                                 1450      1460      1470      1480      1490      1500      1510      1520      1530      1540      1550      1560
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
P_troglodytes_ENSPTRP00000042795          SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
P_pygmaeus_ENSPPYP00000005543             SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
M_mulatta_ENSMMUP00000038848              SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKYYYTDL
E_caballus_ENSECAP00000022364             SVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKCSSYDYEALDEAMSISVEMLREDIKDYYTDL
B_taurus_ENSBTAP00000028867               SVTDSVM-GPKYVVPVESGLGKEKGLEILSLFVNMKKADLPEQAHSIIQECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
C_familiaris_ENSCAFP00000009806           SVTDSVM-GPKYIVAVESDLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWDYYLRQLQNKQFKRIRKSSFYDYEALDEAMSISVEMLREDIKDYYTDL
M_musculus_ENSMUSP00000020157             SVTDSVM-GPKHVVPVESGLGREKGLEILSLFVNMKKEDLPAEAHSIIKECKGSPLVVSLIGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
O_anatinus_ENSOANP00000008896             SVTDSVMVGQKYVVPVESGLGKEKGLEILSLFVNMKKTDLPEQAHSIVQECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLTEEFKDYYKDL
M_domestica_ENSMODP00000009538            SVTDAMM-GPKYAVPVESGLRKEKGLEILALFVNMKKTDLPEQAHSIVKECKGSPLVVSLIGALLHDFPNRWGYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVERLSEDLQKYYKDL
R_norvegicus_ENSRNOP00000010869           SVTDSVM-GPKYVIPVESGLGKEKGLEILSLFVNMKKEDLPVEAHSIIKECKGSPLVVSLVGALLRDFPNRWAYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDL
T_guttata_ENSTGUP00000009081              SVTDAVA-GNKYEVHVESGLAHEKGLEILSLFVNMKISELPEQANSLVRECKGSPLVISLIGALLRDFPSRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEQLDDNYKDYYKDL
G_gallus_ENSGALP00000037436               SVTDAVS-GNKYEIHVESGLTHEKGLEVLALFVNMKISELPEQASCIVTECKGSPLVISLIGALLRDFPSRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEQLSNDLKEYYKDL
A_carolinensis_ENSACAP00000012965         SVTDSVT-GKKYEVPVESGLSHEKALEILSLFVNMEITELPEKADWIVKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFRRIKKSSSYDYEALDEAMSISVEMLPENSKDYYRDL
G_gorilla_ENSGGOP00000008216              SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
X_tropicalis_ENSXETP00000014654           SVTDSLP-GFKEAVHVDSELEHSKGLEILSRFLNIKAEALPSQAHNIIKVSKGSPLVVSLIGALLREFPTRWDFYLTQLKRKQFKRIRKSSSYDYEALDEAMSISVDNLKEDFKEYYNDF
O_cuniculus_ENSOCUP00000010200            SVTDSVM-GPKYVVPVESSLGKEKGLEILSLFVNMKKTDLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLRQLQNKQFKRIRKSSSYDYEALDEAMSISVDVLREDIRDYYTDL
D_rerio_ENSDARP00000008347                ALTDSVS-GVRYEVPVENGLDEEKALEILALYVNGKMHKLPEQARSIVSECKGSPLVVSLIGALLREFPDRWSYYLRQLQQKQFKRIRKSSSYDYEALDQAMDASLQVLEAEHQELYRDL
T_rubripes_ENSTRUP00000033561             SLTDSVG-GAKYEVEVESGLDEKKGLEILALYTDNKPHGLPEEARSIVRECKGSPLVMSLIGALLKEKPNRWCYYLRQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPPEHQELYKDL
T_nigroviridis_ENSTNIP00000013938         SLTDSVG-GNKYEVEVESGLDENKGLEILALYTDNKPHGLPEEACSIVRECKGSPLVVSLIGALLKEKPNRWSYYLRQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPDEHQELYKDL
G_aculeatus_ENSGACP00000026214            SLADSVS-GSRYEVEVESGLDENKGLEILALYTKTKLKGLPEEARSIVRECKGSPLVVSLIGALLREKPNRWRYYLGQLQQKQFKRIRKSSSYDYDALDQAMAASIEVLPDEHREFYKDL
O_latipes_ENSORLP00000019346              SLADVVN-GSKHEVEVNSGLDEDKALEILSQLSKIEMYRLPEEALSIVKKCQGSPLAVSMIGSLLRENPDRWGYYLRQLEKKQFRRIRKSSSYNYEALDQAIAAGIEDLSDDYRDLYNLL
C_elegans_Y45F10B.10                      TAPDNLS----LFMTSSNVAPVNAVFAVTQTVNVDVISENEVVGMVQKMAEKVDKKLTNEQISAIRPLMAAKDGILIAKSFTHEILFNGNSSMKGGMDGRMTRIEKEFGKLAVGNAVKFI
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            SLPQKVH----LVMSMSTSTGLADILQCRRDAHVVALRSLEPTARAQLVRQELALYGKRLEETPFNN-------------QMRLLLVKRGAALPLYLRLATDHLRLFTLFEQMSEQLRTL
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 KLPRCVH----LVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNN-------------QMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTL
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          KLPRCVH----LVLSVSSDAGLGETLEQSQGAHVLALGPLEASARARLVREELALYGKRLEESPFNN-------------QMRLLLVKRESGRPLYLRLVTDHLRLFTLYEQVSERLRTL
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           SLPRRVH----LVLSVSSDSGLGETLQQSQSAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNN-------------QMRLLLAKQGSSLPLYLHLVTDYLRLFTLYEQVSERLRTL
D_melanogaster_FBpp0085899                SLPWNVQ----IICSSTTPVEQLKFTPMQRDRFKSIEYQFDLNMGDYATKLKI----------PPQC-------------------IPGDVSFALYVEQQFDQLERHYGRQAVGDLASYI
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              KLPRCVH----LVLSVSRDAGLGETLEQSQGAHVVALGPLEASARARLVREELALYGKRLEESPFNN-------------QVGKLWFLIMSPSPLPLALPVSMSRSVLLTFQVSERLRTL
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           HLPQRIN----LVLSVTEGSSLGYSLARQKDTVSISLTSLQPSDRAELVRHWLAVYGKKLEESAFNN-------------QMRLLLIKKGTKHPLYLTMACEELRATAVFERLSDDIEKL
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             TLPRWVH----LVLSMSTDAGLGESLEQSQGAHVVALGPLEPSARARLVREELALYGKRLEESPFNN-------------QMRLLLVKRGSALPLYLRLVTDHLRLFTLYEQVSERLRTL
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   SLPWNVF----LVVSTTVPIESLRLTPMQKERFKCADYFFDLSLEQNETKIKHWGVVPSCTEAPPDE-------------------LP---TFAQLVNGLFDAMEQQFGVKGFSRLAIYI
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               ILPRWVH----LVLSVSSDSGLGETLEQRQGAHVVALGPLEPSARAQLVREELALYGKRLEESPFNN-------------QMRLLLVKRGSVLPLYLRLVTDHLRLFTLYEQVSERLQTL
A_aegypti_AAEL001276-PA                   SLPWNVF----LVVSTTVPIDSLKLTPMQKERFKYSDYFFDLSLEQNETIVRK-----------VDS-------------------SQ---SFEEYVNNIFNAMEKRFGRKGFSKLAIYI

                                                 1570      1580      1590      1600      1610      1620      1630      1640      1650      1660      1670      1680
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK
P_troglodytes_ENSPTRP00000042795          SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK
P_pygmaeus_ENSPPYP00000005543             SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK
M_mulatta_ENSMMUP00000038848              SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNCSQLQDLHK
E_caballus_ENSECAP00000022364             SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLTEKNRSQLQDLHR
B_taurus_ENSBTAP00000028867               SILQKDVKVPTKVLCILWDLETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFLYYLHDLQV---------DFLAEKNRSQLQDLHK
C_familiaris_ENSCAFP00000009806           SILQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFRYYLHDLQV---------DFLIEKNRNQLQDLHK
M_musculus_ENSMUSP00000020157             SILQKDVKVPTKVLCVLWDLETEEVEDILQE---------------------------------------FVNKSLLFCNRNGKSFCYYLHDLQV---------DFLTEKNRSQLQDLHR
O_anatinus_ENSOANP00000008896             SVLQKDVKVPTKVICILWEMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKTFHYYLHDLQV---------DFLTEKNRSQLQELHK
M_domestica_ENSMODP00000009538            SILQKDVRVPTKVLCILWDMETEEVEDILQE---------------------------------------FINKSLLFYDRNGKSFRYYLHDLQV---------DFLMEKNRDQLKELHR
R_norvegicus_ENSRNOP00000010869           SILQKDVKVPTKVLCVLWDLETEEVEDILQE---------------------------------------FVNKSLLFCNRNGKSFCYYLHDLQV---------DFLTEKNRSQLQDLHR
T_guttata_ENSTGUP00000009081              SILPKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFHYYLHDLQL---------DFLTEKNRNQLQELHK
G_gallus_ENSGALP00000037436               SILPKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGNSFHYYLHDLQL---------DFLTEKNCNQLQELHK
A_carolinensis_ENSACAP00000012965         SVLQKDVKVPSKVFCVLWDIETEEAEDILQG---------------------------------------FVNKSLLFCDRNGKSFHYYLHDLQL---------DFLTEKNRDQLQALHK
G_gorilla_ENSGGOP00000008216              XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------------------------XXXXXXXXXXXXXXXXXXXXXXXXX---------XXXXXXXXXXXXXXXX
X_tropicalis_ENSXETP00000014654           SIIEKDVKVPTQVLCILWDMEREDVEDMMQE---------------------------------------FVNKSLVYCDRNGKSYSYYLHDLQL---------DYLTERNRDRLTVLHS
O_cuniculus_ENSOCUP00000010200            SIFQKDVKVPTKVLCILWDMETEEVEDILQE---------------------------------------FVNKSLLFCDRNGKSFSYYLHDLQV---------DFLTEKNRSQLQXXXX
D_rerio_ENSDARP00000008347                SVMQKDIKVPAKVLSVLWGLELEEVEDVLQE---------------------------------------FVNKSLLFRDCNQRPYRYYLHDLQL---------DFLAEQNRDQIAELHK
T_rubripes_ENSTRUP00000033561             TVLEKDIKIPAKVLSVLWVLEPEEVEDILEE---------------------------------------FVNKSLLYVDINHKPYLYYLHDLQL---------DFLVEQNQAQLERLHT
T_nigroviridis_ENSTNIP00000013938         TVFEKDIKIPAKVLSVLWDLEPEDVEDILEE---------------------------------------FVNKSLLFVDSNHRPYLYYLHDLQL---------DFLVEQNRTQLERLHT
G_aculeatus_ENSGACP00000026214            TVLEKDTKVPAKVLAVLWDLETEEVEDILEE---------------------------------------FVNKSLLFVDSHNKPFLYYLHDLQL---------DFLVEQNRTQLESLHS
O_latipes_ENSORLP00000019346              TVLHKDVKVTAKMMSVLWGQDQVDTEDTLSE---------------------------------------FVNRAMLFVDSQSQPNVFYLHDLQL---------DFLLEQNKNQLKVLHK
C_elegans_Y45F10B.10                      AASSHGLTRLEIHDAI--SADREVLEEMNMSIVYSLLTLDGIIEALGPILRKVIIDDRQIIGIAHSGLISWLRNRYLTSSQDIRSAHLQLSDLFA---------DLLIDNEQSPRHEIAY
C_intestinalis_ENSCINP00000010464         ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000008927            PAT-----VPLLLQHVLGVLEQEHEPDILPLALAALQVTRSGLTV--DRLHGVISTWRALS-SETVDWAEAMAARNKGDPYPMGPFTYLIQSLRRLLGE-----G-SLELPGARLRLPPG
D_rerio_ENSDARP00000023281                ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004526-PA                   ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 PAT-----VPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFACLVQSLRSLLGE-----G-PLERPGARLCLPDG
T_rubripes_ENSTRUP00000017221             ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000019387         ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          PAT-----VPLLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLL-E-----G-PLERPGARLCLPDG
T_guttata_ENSTGUP00000013749              ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             ------------------------------------------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           PAT-----LPLLLQHILSTLEQEHGHNVLPQALTALEVTHSGLTV--DQLHAVLSTWLTLP-KETKSWEEAVAASHSGNLYPLAPFAYLVQSLRSLLGE-----G-PVERPGARLCLSDG
D_melanogaster_FBpp0085899                TCSEYGLSETELLELLMPTDDPESLIETKNGHFSFATFKKIHREMDLLLLLHDKIMSGKVLIQWRHNYCASVAKRRYMDVQRTRSLHCELANLFFPQDEDESTLENESNRSESKSVISLK
P_troglodytes_ENSPTRP00000001997          ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              PAT-----VPLLLQHILSTLEQEHGPDVLPQALTALEVTRSGLTV--DQLHGVLSVWRTLP-KGTKSWEEAVAAGNSGDPYPMGPFAYLVQSLRSLLGE-----G-PLERPGARLCLPDG
B_taurus_ENSBTAP00000026561               ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           PAT-----LPALIQRRLESLEQEHGVTTVSIALAVICLSRKGLPE--RDLLRILSSLQALNCVFTAKWNAMLAAFAGAQNLPMATFALLLRGVRSVLGL-----WLPALTSDHRLHLPSC
A_aegypti_AAEL004364-PA                   ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             ------------------------------------------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             PAT-----VPLLLQHILGTLEQEHGPSVLPQALATLEVTRSGLTV--DQLHGVLSAWRILP-MGTKTWEEAVAAGDSGDPYPMGPFAFLVQSLRSLLGE-----G-PLERPGARLCLRDG
X_tropicalis_ENSXETP00000021860           ------------------------------------------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   TCSEYGLTETELLELLMPTQDADLVIKSNEGDFNFSTFRTIRNQMK--LILREKLMSGKLLIVWRHSICAEITRVRYMTPDITRSIHSELVNLFFPPDGDDSE-DMSTEQHSRKSMHCFT
M_domestica_ENSMODP00000027702            ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               PAT-----VPLLLQHVLGTLEQEHGPDVLPQALATLEATRSGLTV--DQLHGVLSAWRILP-RGSKSWEEAVAAGNSGDPYPMGQFAYLVQSLRSLLGE-----G-PLERPGARLCLQDG
A_aegypti_AAEL001276-PA                   TCSEYGLTETEFLELLMPTQDSDALIDTNEGGFNFSTFRTARNEMR--ALLREKLMSGKLLIVWRHSICSEITKVRYMTPDISRSVHSEIVNLFFPPDSEESD-EISSAQNSRKSSHYKK

                                                 1690      1700      1710      1720      1730      1740      1750      1760      1770      1780      1790      1800
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN
P_troglodytes_ENSPTRP00000042795          KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN
P_pygmaeus_ENSPPYP00000005543             KIITQFQRYHQSHTLSPDQED----------------------CMYWYNFLAYHMASAKMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN
M_mulatta_ENSMMUP00000038848              KIITQFQRYHQPHTLSPDQED----------------------CMYWYNFLAYHMASAKMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN
E_caballus_ENSECAP00000022364             KIITQFQRHHRLHTLSPDQED----------------------CMYWYNFLAYHMASANMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CSVCENFQEFLSLN
B_taurus_ENSBTAP00000028867               KMVTQFQRHHQLYSLSPDQED----------------------CMYWYSFLAYHMASANMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----GIDCENFQEFLSLN
C_familiaris_ENSCAFP00000009806           KIVTQFQKHYQPHTLSPDQED----------------------CMYWYNFLAYHMASASMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVCENFQEFLSLN
M_musculus_ENSMUSP00000020157             KMVTQFQRYYQPHTLSPDQED----------------------CMYWYNFLAYHMASANMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVAYRHILDEKD----CAVCENFQEFLSLN
O_anatinus_ENSOANP00000008896             KIVNQYQKYYQLRTLSPDQDD----------------------CMYWYNFLAYHMASANMHKELCAL-MFSLDWIKSKTELVGPAHLIHEFAEYSHILDEKD----CTVCENFQEFLSLN
M_domestica_ENSMODP00000009538            KVVTQFQRYCQAHSLPSDQED----------------------SMYWYNFLAYHMASADMRQELCNL-MFSLDWIKAKTELVGPAHLIHEFMRYRHLLDKKD----CTICENFQEFLSLN
R_norvegicus_ENSRNOP00000010869           KMVTQFQRYHQPHTLSPGQED----------------------CMYWYNFLAYHMASAGMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVCENFQEFLSLN
T_guttata_ENSTGUP00000009081              NIVNQYKKYYKLNTPVLSQED----------------------CMYWYNFLAYHMAGAKMQQELRDL-MFSLDWIKAKTELVGPAHLIHEYVEYSSVLDQKD----STVRENFQEFLSLN
G_gallus_ENSGALP00000037436               NIVNQYKRYYKLHVPVLSQED----------------------CMYWYNFLAYHMAGANMQKELRDL-MFSLDWIKAKTELVGPAHLIHEYVEYSSVLDEKD----SIIRENFQEFLSLN
A_carolinensis_ENSACAP00000012965         KVVHQYKNHYAQYMPNSTQED----------------------WMYWYNFLAYHMSSASMHDELCAL-MFSLEWIKTKTELVGPAHLIHEYVEYSEILNEKD----PIARENFQEFLSLN
G_gorilla_ENSGGOP00000008216              XXXXXXXXXXXXXXXXXXQED----------------------CMYWYNFLAYHMASAKMHKELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CAVSENFQEFLSLN
X_tropicalis_ENSXETP00000014654           KLVDQYKKHYSSKSPAVDQED----------------------SVYWYHYLAYHMAKANMHQDLCSL-LFSLNWLKAKTELFGTAHLIHEFVQYRNILDNQN----AKAREHFQEFIAVN
O_cuniculus_ENSOCUP00000010200            XXXXXXXXXXXXXXXXXXXXX----------------------XXXXXXXXXXXXXXXXXXXELCAL-MFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKD----CTVCENFQEFLSLN
D_rerio_ENSDARP00000008347                KMVRQYQRFYSKRPPDSADKD----------------------SLYWYQFIPYHMAKAGLSKELYSL-MFSLDWVKEKARIMGSAHLINDYVEYGEILDKEN----SEVRVQFQEFLSLN
T_rubripes_ENSTRUP00000033561             KVVQQYQLHYKGDPPLSGDEE----------------------CLYWIRFLTLHMAKAGLSQELYSL-MFSLDWVSIKARIMGPAHLISDYVEYGHILDKKN----SDVRSQFQEFLSLN
T_nigroviridis_ENSTNIP00000013938         KVVQQYQLHYKDGPPLSGDEE----------------------CLYWVRFMTYHMAKAKLSQELYSL-MFSLDWVSIKAQIMGPAHLISDYVEYGHILDKEN----SDVRSQFQEFLSLN
G_aculeatus_ENSGACP00000026214            KVVHQYQQHYKDAHSTSGDEE----------------------CLYWIRFLTYHMAKANLFQELYSL-MFSLDWVSTKAQLMGPAYLINDYVEYGPILDKEN----SETRSQFQEFLSLN
O_latipes_ENSORLP00000019346              KMVERYQHRYKDRPLTSRDEE----------------------SLYWIRYLAYHMANANLFQELHSL-LFSLDWISVKGQIMGPAHLINDYLEYGSILDKEN----NEMCSEFQEFLSLS
C_elegans_Y45F10B.10                      QSFSQGIKRDNGSP-----------------------------NFRRLRLLWYHCLHSGNLDRLKELSLCHFEYVDYVTRYFGISHLLSLYEECATQILHHD------LQVISEQVLVPA
C_intestinalis_ENSCINP00000010464         ---------------------------------------------------------NTQGRYVAAAACENVCVWDMRTLQLVL------------------------------------
O_latipes_ENSORLP00000010395              ---------------------------------------------------------GERGRYVAVAACEHVFVWDVRKGEKVL------------------------------------
T_nigroviridis_ENSTNIP00000007980         ---------------------------------------------------------GEKGRYVAAAACEHVFIWDVRKGEKVM------------------------------------
T_guttata_ENSTGUP00000006840              ---------------------------------------------------------SRDGKFMFCPCGSKVNVVDVETGALLHS-----------------------------------
T_nigroviridis_ENSTNIP00000004057         ---------------------------------------------------------SKDENYIFCTCGSRVNVLEISTGKIVHS-----------------------------------
M_domestica_ENSMODP00000008927            PLSSAVELRYRKRPGLKTKAHVLIAVQLWKMCDPEALGTFHNCHPEALNDLPYHLVQSGNHSLLASL-LTNLNVTATYLELGLLSQLGEAHALYASSVPMSEPVSSETDVIAFHTFLKQQ
D_rerio_ENSDARP00000023281                ---------------------------------------------------------GEKGRYVAVGACEHVFIWDVRKAEKVL------------------------------------
G_gallus_ENSGALP00000008904               ---------------------------------------------------------SRDGKFMFCPCGTKLNVIDVETGALLHS-----------------------------------
G_aculeatus_ENSGACP00000015863            ---------------------------------------------------------SKDEKYIFCTCESRVNVLEISTGKIVHS-----------------------------------
A_aegypti_AAEL004526-PA                   ---------------------------------------------------------TSDGSEMLCQNAGAINLVSVTDDTVEPVIF---------------------------------
M_musculus_ENSMUSP00000060613             ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
H_sapiens_ENSP00000262715                 PLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKF-LTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRTFLRQQ
T_rubripes_ENSTRUP00000017221             ---------------------------------------------------------SKDENYIFCTCGSRINVLEISTGKIVHS-----------------------------------
C_intestinalis_ENSCINP00000019387         ---------------------------------------------------------SNSENYLLCVCGDKIKIVNVDSGLVEKE-----------------------------------
G_gallus_ENSGALP00000023833               ---------------------------------------------------------GERGRCVAVPACEHVFVWDARKGEKVL------------------------------------
P_troglodytes_ENSPTRP00000010340          PLRTAAKRRYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKF-LTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFHTFLRQQ
T_guttata_ENSTGUP00000013749              ---------------------------------------------------------GERGRYVAVPACEHVFVWDTRKGEKVL------------------------------------
T_rubripes_ENSTRUP00000006345             ---------------------------------------------------------GEKGRYIAAAACEHVFIWDVRKGEKVM------------------------------------
H_sapiens_ENSP00000308179                 ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
R_norvegicus_ENSRNOP00000012235           PLRTAVKRRYGKRLGLEKTAHVLIAAHLWKMCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAKF-LTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFHNFLKQQ
D_melanogaster_FBpp0085899                DRDREKDSLSAVSAVSAGRKSSSTHHNDDTSTFYNPIAADVSYSMRHVEESWHHLMRSDDTTRFKQIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELIYYTIRKS
P_troglodytes_ENSPTRP00000001997          ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
M_mulatta_ENSMMUP00000011166              ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
M_domestica_ENSMODP00000006461            ---------------------------------------------------------GEKGRYVAVPACEHVFIWDIRKGEKIL------------------------------------
P_pygmaeus_ENSPPYP00000001131             ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
M_mulatta_ENSMMUP00000021364              PLRTAAKRRYGKRPGQEDTAHILIAAQLWKTCDADASGTFRSCPPEALVDLPYHLLQSGNRGLLSKF-LTNIHVVAAHLELGLVSRLLETHALYASSVPKEEQKLPEADVTVFRTFLRQQ
B_taurus_ENSBTAP00000026561               ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
R_norvegicus_ENSRNOP00000026726           ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
A_gambiae_AGAP009615-PA                   ---------------------------------------------------------KPDAQQFLCLNNGTISIVSV-DNLHEPVAL---------------------------------
B_taurus_ENSBTAP00000027147               ---------------------------------------------------------DQTGQHLFCVCGTRVNILDVASGAVLRS-----------------------------------
X_tropicalis_ENSXETP00000035244           LLRDAVEKRYLMKRDVTKAAHLLMAAHFWTVCSPEDPDSVPVINAECLSELSHHLLCSEQLHTLGWL-LTHLPFLRVHAALGLLPHLCQVYSMYDCTIHELDRQVSKLPVDVFREFIHNS
A_aegypti_AAEL004364-PA                   ---------------------------------------------------------GVDGRFVAVAGAEQVLVWNTRLGEKVL------------------------------------
O_anatinus_ENSOANP00000004860             ---------------------------------------------------------GEKGRYVAVPACEHVFIWDPRKGEKIL------------------------------------
E_caballus_ENSECAP00000005446             ---------------------------------------------------------GEKGRYVAVPACEHVFIWDLRKGEKIL------------------------------------
S_cerevisiae_YLR222C                      ---------------------------------------------------------SENGKILATPVLDEINIIDLTPGSRKILHK---------------------------------
E_caballus_ENSECAP00000009299             PLRTAAKSRYGRRPGLEKTAHILIAAQLWKACDPDASGTFRSCPPEALGDLPYHLLQSENYGLLTKF-LTNLHVMAAHLELGLISRLLEAHALYASSIPEEGQKLPEADVAVFHTFLRQQ
X_tropicalis_ENSXETP00000021860           ---------------------------------------------------------GERGRYVAVGACEHVFIWDTRRGEKVL------------------------------------
A_gambiae_AGAP004827-PA                   N-EKETKNTALLTAISETERDHCRHRIDDNVTQVLNLGPDISYSIRHVEEAWHHLIKSEDTKKLKEIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELVYYTIRKS
M_domestica_ENSMODP00000027702            ---------------------------------------------------------SQDGQLLFCVCGSGVNVVDATSGNLVRT-----------------------------------
X_tropicalis_ENSXETP00000015707           ---------------------------------------------------------NSDGTYILCTCGNKLNILDIATGAVTYT-----------------------------------
M_mulatta_ENSMMUP00000010429              ---------------------------------------------------------DQTGQHLFCICGTRVNILEVASGVVLRS-----------------------------------
B_taurus_ENSBTAP00000001564               PLRTAARCRYGKRPELEKTAHLLTAAQLWKTCDPDASGTFRRCPPEALADLPYHLLQSGNRGLLAKF-LTSLHVVAAHLELGLTSQLLEAHALYASSVPGEEQKLPEADVAAFHTFLRQQ
A_aegypti_AAEL001276-PA                   RVLREGDSLGVISMCRKGGKIRIQTQHDDNVTQIITLGPDISYSIRHVEESWHHLIKSDDTKKLKEIAVCNFDFLLAAVQTVSISYLRCLIEHVRCYILDRD-------IELVYYTIRKS

                                                 1810      1820      1830      1840      1850      1860      1870      1880      1890      1900      1910      1920
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWINKKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-
P_troglodytes_ENSPTRP00000042795          GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWINKKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-
P_pygmaeus_ENSPPYP00000005543             GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWINKKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-
M_mulatta_ENSMMUP00000038848              GHLLERQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWINKKNITNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-
E_caballus_ENSECAP00000022364             GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWINKKNIKNLSRL-----VVRP-----HTDAVYHACFSGDGQRIASCGAD---KTLQVFKAE-
B_taurus_ENSBTAP00000028867               GHLLGRQPFPNIVQL-----------GLCELETSEVYRQ-AKLQAKQEVDNGMLYLEWVNKKNMKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTLQVFKAE-
C_familiaris_ENSCAFP00000009806           GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDHGMLYLEWINKKNIKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGVD---KTLQVFKAE-
M_musculus_ENSMUSP00000020157             GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLQAKQEGDTGRLYLEWINKKTIKNLSRL-----VVRP-----HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE-
O_anatinus_ENSOANP00000008896             GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLRAKQEVDKGMLYLEWINKKNIKNLSRL-----VVRP-----HTDAVYHACFSEDGQRIASCGAD---KTVQVFKAE-
M_domestica_ENSMODP00000009538            GHLLGRQPFPNIVQL-----------GLCEPETSEVYRQ-AKLRAKQEVDKGKLYLEWINKKTIKKLSRL-----VVRP-----HTDAVYHACFSKDGQRIASCGAD---KTLQVLQAE-
R_norvegicus_ENSRNOP00000010869           GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDTGRLYLEWINKKTIKNLSRL-----VVRP-----HTDAVYHACFSQDGQRIASCGAD---KTLQVFKAE-
T_guttata_ENSTGUP00000009081              GHLLGRQPFPDIIQL-----------GLCQPETSEVYQQ-AKLHAQRE--TGTFYLEWINKKSLKNLYRL-----VVRP-----HRDAVYHACFSKDKQRIASCGAD---KTLQVFKAE-
G_gallus_ENSGALP00000037436               GHLLGRQPFPDITQL-----------GLCQPETSEVYQQ-AKLRAQRE--TGTFYLEWINKKSLKNLSRL-----VVRP-----HRDAVYHACFSRDRQRIASCGAD---KTLQVFKAE-
A_carolinensis_ENSACAP00000012965         GHLLGRQPSLDIVQL-----------GLCQPESSKVYQQ-AKLQAQQGLDKGSFYVEWMNKQSIKNTYRL-----VVRP-----HTDAVYHACFSQDRHRIASCGAD---KTLQIFKAE-
G_gorilla_ENSGGOP00000008216              GHLLGRQPFPNIVQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWXXXXXXXXXXXX-----XXXX-----XXXXXXXXXXSEDGQRIASCGAD---KTLQVFKAE-
X_tropicalis_ENSXETP00000014654           GHLLGSNPDVSIVQL-----------GLGQAEDSEVYKQ-AILQAKEELQSGALYVNWINKQSIKNLPTL-----VVRP-----HKDAVFHACFSSDGQRIASCGAD---KTLQVFKSE-
O_cuniculus_ENSOCUP00000010200            GHLLGRQPFPNIIQL-----------GLCEPETSEVYQQ-AKLQAKQEVDNGMLYLEWI-KKNIKNLSRL-----LVRP-----HTDAVHHASVSA-AHRIASCGAD---XXXXVFKAE-
D_rerio_ENSDARP00000008347                GHHLEQRPFPDVVQL-----------ALSQPDRSEVYRQ-ALMQAQKRASRGQIYLNWVNKNIEEGLSRL-----VMHP-----HQGAVYYACFSKDGSKIASCGAS---KALRVFKST-
T_rubripes_ENSTRUP00000033561             GHHLEQRPFPDVVQL-----------ALSQPHASDVYRQ-ALQEAQEQASTGKLYFDWLNKNSMESLSHL-----VIHP-----HQGSVYSACFSRDGTKIASSGAC---KTLKVFKST-
T_nigroviridis_ENSTNIP00000013938         GHQLEQRPFPDVVQL-----------ALSQPHASEVYRQ-ALQQAQERASTGKLYFDWLNKNSVESLSRL-----VIHP-----HQGSIYSACFSHDGTKIAASGAY---KTLKVFKST-
G_aculeatus_ENSGACP00000026214            GHHLEQRPFPDVVQL-----------ALSQPRTSEVYKQ-ALLQARDRATTGKLYFEWLNKGSVESLSRL-----VIHP-----HQGSIYSACFSQDGAKIASSGAS---KMLKVFKST-
O_latipes_ENSORLP00000019346              GHYLEQRPFPDIVQL-----------ALSQPHTSEVYRQ-ARLLAQERAKDGKLYFDLINETSVDSLSRL-----VIHP-----HQGSLY-ACFSNDGTKIASCGAT---KNLKVFKST-
C_elegans_Y45F10B.10                      LVTMARDSEQLAAEVIGRLRFTRH--ENSHFLNSLVDQAMSWVDLYNRQPLLVPLTCWISPPATKVCRSF-----TLKD-----WKPGNTVLTLSANHQYILISGNQSDPGVIYAYHIA-
C_intestinalis_ENSCINP00000010464         ---------------------------------------------------------------------------LLQG-----DNQEVTCIKSSPNSQHLAVGYVD---GTIRIFSLV-
O_latipes_ENSORLP00000010395              ---------------------------------------------------------------------------ILQG-----QKHEVSFLCPSPDGVHVAVGYED---GAVRIFSLL-
T_nigroviridis_ENSTNIP00000007980         ---------------------------------------------------------------------------ILEG-----QKHEVTFLCPSPDGVHVAVGYED---GAVRIFSLL-
T_guttata_ENSTGUP00000006840              ---------------------------------------------------------------------------LQQE-----EEEDVTAFVLSPDDEVLVTGSRA---LLLRRWHWR-
T_nigroviridis_ENSTNIP00000004057         ---------------------------------------------------------------------------VEHD-----DQEDITCFALSSDDELLVTASRA---LLLKQWDWR-
M_domestica_ENSMODP00000008927            SRLLTQYP-ALLTQQ-----------ATNQPSNSPIYQQVPKL---AQRWSSQPILRWLNKPQTMGSQQS---SSLSLV-----PSSMPTAVSLSPNGQWAVVATAS---GIVHLLDTR-
D_rerio_ENSDARP00000023281                ---------------------------------------------------------------------------ILEG-----KKHEVTYLCPSPDGVHIAVGYED---GGVRIFSLL-
G_gallus_ENSGALP00000008904               ---------------------------------------------------------------------------LEQD-----DQEDITSFVLSPDDEVLVTGSRA---LLLKQWNWR-
G_aculeatus_ENSGACP00000015863            ---------------------------------------------------------------------------VQHD-----DQEDITSFALSFDDEMLVTASRA---LLLKQWDWR-
A_aegypti_AAEL004526-PA                   ---------------------------------------------------------------------------GDAD-----ESDAVYTFALSKDSHNVVSAHRS---GLMKLWDKN-
M_musculus_ENSMUSP00000060613             ---------------------------------------------------------------------------ILQG-----NKQEVTCLCPSPDGLHLAVGYED---GAIRIFSLL-
H_sapiens_ENSP00000262715                 ASILSQYP-RLLPQQ-----------AANQPLDSPLCHQASLL---SRRWHLQHTLRWLNKPRTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-
T_rubripes_ENSTRUP00000017221             ---------------------------------------------------------------------------VEHD-----DQEDITSFALSSDDELLVTASRA---LLLKQWDWR-
C_intestinalis_ENSCINP00000019387         ---------------------------------------------------------------------------LSHD-----G-DDVTCLAVSPDDSMIVTSTKS---LLLKQWEWKM
G_gallus_ENSGALP00000023833               ---------------------------------------------------------------------------ILKG-----SKHE-SCLRPSPDGLHLAVGYED---GSIRIFSLL-
P_troglodytes_ENSPTRP00000010340          ASILSQYP-RLLPQQ-----------AANQPLDSPLCHQAPLL---SQRWHLQHTLRWLNKPQTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-
T_guttata_ENSTGUP00000013749              ---------------------------------------------------------------------------ILKG-----LKQQVSCLCPSPDGLHLAVGYED---GAIRVFNLL-
T_rubripes_ENSTRUP00000006345             ---------------------------------------------------------------------------ILEG-----QKHEVTFLRPSPDGVSIAVGYED---GAVRIFSLL-
H_sapiens_ENSP00000308179                 ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
R_norvegicus_ENSRNOP00000012235           ASLLTQYP-LLLLQQ-----------AASQPEESPVCCQAPLL---TQRWHNQCILKWINKPQTLKGQQ-----SLSLP-----ISSSPTAVAFSPNGQRAAVGTAG---GTIYLLNLR-
D_melanogaster_FBpp0085899                SDVLTRDPMQLGSQLISWLRPISEHDDDDNSLLSMTVRSATAWCDGYAVPLLVPLTGWLPAPLPSQIRT------MTVS-----GTGCIRAVWLAPSKQHLILATSS---GDVQQWHIM-
P_troglodytes_ENSPTRP00000001997          ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
M_mulatta_ENSMMUP00000011166              ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
M_domestica_ENSMODP00000006461            ---------------------------------------------------------------------------ILQG-----LKHEVTCLCPSPDGLHLSVGYED---GSIRIFSLL-
P_pygmaeus_ENSPPYP00000001131             ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
M_mulatta_ENSMMUP00000021364              ASILSQYP-QLLPQQ-----------AANQPLDSPLCQQAPLL---SQRWHLQHTLRWLNKPQTMKNQQS---SSLSLA-----VSSSPTAVAFSTNGQRAAVGTAN---GTVYLLDLR-
B_taurus_ENSBTAP00000026561               ---------------------------------------------------------------------------ILQG-----LKHEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
R_norvegicus_ENSRNOP00000026726           ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GAIRVFSLL-
A_gambiae_AGAP009615-PA                   ---------------------------------------------------------------------------GEQETDGEIAEDVIYTFAVSNTGNSIVSGHRS---GLLKLWDGE-
B_taurus_ENSBTAP00000027147               ---------------------------------------------------------------------------LEQE-----DQEDITAFDLSPDDKVLVTASRA---LLLAQWAWQ-
X_tropicalis_ENSXETP00000035244           LPVLSKNP-SLFYQQ-----------ALNEPDCSPVCFQARVIIDNRKECTSHLTMLWNNKPAYMSICRSLFPDSKSLE-----IPSLLGCVSLSPSGRMAAVGASS---GALHLINTD-
A_aegypti_AAEL004364-PA                   ---------------------------------------------------------------------------EFAR-----DKQEVTFLRPSPDRKHLAVGYTD---GVIEMFSFE-
O_anatinus_ENSOANP00000004860             ---------------------------------------------------------------------------ILQG-----LKQEVSRLCPSPDGLHLAVGYED---GTVRIFSLL-
E_caballus_ENSECAP00000005446             ---------------------------------------------------------------------------ILQG-----LKQEVTCLCPSPDGLHLAVGYED---GSIRIFSLL-
S_cerevisiae_YLR222C                      ---------------------------------------------------------------------------ISNE-----DEQEITALKLTPDGQYLTYVSQA---QLLKIFHLK-
E_caballus_ENSECAP00000009299             APVLSQYP-LLLPQQ-----------AANQPLDSPLCLQAPQL---SQRWHLQRMLRWLNKPQTTRGQQT---TSLSLA-----VSSSPTAVAFSPSGQRAAVGTAS---GTVYLLDLR-
X_tropicalis_ENSXETP00000021860           ---------------------------------------------------------------------------ILQG-----QKQEVTRLCPSPDGLSLAVGYED---GSIRIFSLL-
A_gambiae_AGAP004827-PA                   SDVLTRDPMQLGAQLISWLKSVSAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLPVPLPSQIRC------ITVP-----GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM-
M_domestica_ENSMODP00000027702            ---------------------------------------------------------------------------FQQD-----DQEIITAFDLSPNNEILVTGSRA---LLLTQWAWR-
X_tropicalis_ENSXETP00000015707           ---------------------------------------------------------------------------IEQD-----DQEDITSFALSPDDEILVTGSRA---LLLKQWDWK-
M_mulatta_ENSMMUP00000010429              ---------------------------------------------------------------------------LEQE-----DQENITAFDLSPDDEVLVTASRA---LLLAQWAWR-
B_taurus_ENSBTAP00000001564               APILSRYP-LLLHQQ-----------VANQPLDSPLCRQAPRL---SQRQHLQCMLHWLNKPQTLKHQQS---SSLSLA-----VSSSPTAVAFSPNGQRAAVGTAN---GTVYLLDLR-
A_aegypti_AAEL001276-PA                   SDVLTRDPMQLGAQLISWLKSVAAH-EGPQALLSVTVQSATAWCDGYTVPLLVPLTGWLPVPLPSQIRC------MTVP-----GPGPVRCIEVSPSKQHLILSPKV---GDPQLWHIM-

                                                 1930      1940      1950      1960      1970      1980      1990      2000      2010      2020      2030      2040
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
P_troglodytes_ENSPTRP00000042795          TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
P_pygmaeus_ENSPPYP00000005543             TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
M_mulatta_ENSMMUP00000038848              TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSVTGELVHTYDE-HSEQVNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
E_caballus_ENSECAP00000022364             TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTN-NSH-HLLLATGSSDSF--LK----LWDLNEKDCRNTMFGHTNSVN--HCRF
B_taurus_ENSBTAP00000028867               TGEKLLEIKA-HEDEVLCCAFS--ADDKFIATCSVDKKVKIWNSMTGELVRIYDE-HSEQVNCCHFTN-NSN-HLLLATGSNDYF--LK----LWDLNQEECRNTMFGH-NSVS--HCRF
C_familiaris_ENSCAFP00000009806           TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGGLVHVYDE-HSEQVNCCHFTN-NSH-YLLLATASSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
M_musculus_ENSMUSP00000020157             TGEKLLDIKA-HEDEVLCCAFS--SDDSYIATCSADKKVKIWDSATGKLVHTYDE-HSEQVNCCHFTN-KSN-HLLLATGSNDFF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
O_anatinus_ENSOANP00000008896             TGEKLLEIKA-HEDEVLCCAFS--PDDKFVATCSTDKKVKVWNSQTGKLVHTYEE-HTEQVNFCQFSN-TSS-HPLLATCSNDQF--LK----LWDLNQKGCRNTMFGHSDSVN--HCKF
M_domestica_ENSMODP00000009538            TGERLLEVEA-HEDEVLCCAFS--KDGLFIATCSADRKVKIWNSRTGELVHTYDE-HTEQVNCCHFTN-MEH-HLLLATGSSDCF--LK----LWDLNKQECRNTLFGHMNSVN--HCQF
R_norvegicus_ENSRNOP00000010869           TGEKLLDIKA-HEDEVLCCAFS--SDDSYIATCSVDKKVKIWDSGTGKLVHTYEE-HSEQVNCCHFTN-KSN-HLLLATGSNDSF--LK----LWDLNQKECRNTMFGHTNSVT--HCRF
T_guttata_ENSTGUP00000009081              SGERLLEINA-HDDEILCCTFS--ADGEFVATCSSDKKVKVWNSRTGQCRCVYEE-HSEQVNCCQFNN-KSG-QYLLATCSNDTF--IK----IWDLNKKYCRNTMIGHENSVN--HCRF
G_gallus_ENSGALP00000037436               SGERLLEISA-HDDEILCCTFS--ADDKYVATCSADKKVKIWNSRTGKCLYVYEE-HTEQVNCCQFNN-RRG-QYLLATCSDDTY--IKNTVQLWDLKDKYCRNTMFGHVNAVS--HCRF
A_carolinensis_ENSACAP00000012965         SGEKLLEVKA-HDDEVLCCSFS--ADDRFVATCSADKKVKVWNSRTGQPVCIFEE-HTEQVNCCQFSN-TNHNQFLLATCSNDSF--IK----LWDLNKKYCRNTLFDHSSSVT--HCRF
G_gorilla_ENSGGOP00000008216              TGEKLLEIKA-HEDEVLCCAFS--TDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTN-SSH-HLLLATGSSDCF--LK----LWDLNQKECRNTMFGHTNSVN--HCRF
X_tropicalis_ENSXETP00000014654           TGEKLLEIEA-HDDEVLCCAFS--ADEKLLATCSADRKVKIWNAKTGKPLRVYEE-HIEQVNCCQFTN-SLS-APLLATCSNDCL--IK----LWNSEKNYCHNTLIGHIESVY--HCRY
O_cuniculus_ENSOCUP00000010200            TGEKLLEIKA-HEDEVLCCTFS--TDENFIATCSVDRKVKIWNSVTGELVRTYDE-HSEQVNCCCFTN-QSQ-YLLLATGSSDFF--LK----LWDLNQNVCRNTMFGHTNSVN--HCRF
D_rerio_ENSDARP00000008347                SGEKLLELQA-HEEDVLCCAFS--PDDRHIATCASDKKVKLWNVERGVLIREFEVEHEEQINHCQFTN-TGR-RVLLATCSNDKFTNTK----LWNPNKKTSQNTMFGHMEPVN--HCCF
T_rubripes_ENSTRUP00000033561             TGEKLTEIMA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNVEQARLLRVFEEEHEEQVNHCQFTN-TMR-RLLLVTCSNDACMNVK----LWNLNKPSSQNTMFGHFEPVN--HCCF
T_nigroviridis_ENSTNIP00000013938         TGEKLTEIQA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNAERAMLLRVFEEEHEEQVNHCQFTN-TMR-RLLLVTCSNDEFMNVK----LWNLNKPSSQNTMFGHTEPVN--HCCF
G_aculeatus_ENSGACP00000026214            SGEKLMEIQA-HDDEVLCCAFS--PDDRLLATCSSDRKVKVWNVERAMLLRVFEEEHEEQVNHCQFTNSTTP-RLLLATCSNDKVLNTK----LWNLNKPSSQNTIFGHFEPVN--HCCF
O_latipes_ENSORLP00000019346              SGEKLSEFEL--RDEVVCCAFS--PDDSLLAVCSSGRTIQVWNVHQVKLLRTFQEEHKEQINHCVFTN-TTR-RLLLATCSNDQMGNAK----LWNLNKPTCQNTIFGHFEPVN--HCCF
C_elegans_Y45F10B.10                      SEQLIGTFKG-HTAAVTCLCSS--NDSSLFVSTSFDKTVNVWVFSQSTPTMSLTH-HTAKVTCAILTS-D---DQYLITASADSS--AK----MIKLETGEVMRSFNDHTGSVV--SLQL
C_intestinalis_ENSCINP00000010464         TAESDVTFSG-HRTAISCLAFD--KAGMKLASGSHDTEVVVWDLVNESGLYRLKG-HKGIITDCYFVK-Q---RNMLITSSKDTY--VK----WWDLDTQHCFKTMVGHRSEVW--SFCL
O_latipes_ENSORLP00000010395              NGESSVAFNG-HKTAVTVMNYD--ALGARLVTGSKDTDVIVWDIINECGLYRLRG-HKDAITQALFLK-N---KNLMVTSSKDSF--VK----WWDLDTQHCFKTMVGHRSEVW--ALAL
T_nigroviridis_ENSTNIP00000007980         NGESNVSFNG-HKSAVSVMRYD--GLGARLVTGSKDTDVIVWDIINECGLYRLRG-HKDLITQALFLR-D---RNLLVTSSKDSF--VK----WWDLDTQHCFKTIVGHRSEVQCGGMVL
T_guttata_ENSTGUP00000006840              EPSCERTWRAVHTAPVATMAFD--PTATLLATGGCDSTIKIWDMTKHYCTHNLKG-SSGVVHLVEFHP-DLS-RLQLFSSCIDYK--IR----IWDLSSSKCLAVLEGHFSAVT--SLAF
T_nigroviridis_ENSTNIP00000004057         QAQCTRSWRAIHTAPVASMTFD--STSTLLATGGCDGTIKLWDVVKQYCTHNLRG-SSGVIQLVQFHP-DID-RLQLFSSSMDCS--IR----IWDLSSSQCVCVLQSHYSAVT--SLSF
M_domestica_ENSMODP00000008927            TWQEEKSIVS-GCDGISSCLCP---SNSTVFLAASDGLLELWDLQGGWRVFQTKA-HQLQITDCCLSP-D---HRLLATVSLDRH--LK----LWDTVHGKLASQHL-SQKPLN--CVAF
D_rerio_ENSDARP00000023281                NGESNVSFSG-HKSAVSVIKYD--ALGARLVTGSRDTDVIVWDVINECGLYRLKG-HKDAITQVLFLE-S---KNLLITSSKDSF--VK----WWDLDTQHCFKTMVGHRSEVW--GMVL
G_gallus_ENSGALP00000008904               ENRCVRTWKAVHIAPVATMVFD--STSTLLATGGCDSTIKIWDMIKQYCTHNLKG-SSGVVHLVEFHP-DIS-RLQLFSSSMDYK--IR----IWDLNSSKCVAVLDGHFSAVT--SLAF
G_aculeatus_ENSGACP00000015863            EAQCTRSWRAIHTVPVASMTFD--STSTLLATGGCDGTIKLWDVLKQYCTHNLKG-SSGVVHLVQFHP-DIS-KLQLFSSSLDCG--IR----LWDLRSSQCVCVLQSHYSAVT--SLSF
A_aegypti_AAEL004526-PA                   SRQVSKMWRGLHQGPITKLVFS--DDDTLIASGGTDTTVRVWDPKEQVCKGTLRG-CQGVINLLVFHP-DVE-SKILLAAGDDVK--IN----AWNYETRELVKSFAGHFSKVT--GVSF
M_musculus_ENSMUSP00000060613             SGEGNITFNG-HKAAVTSLKYD--QLGGRLASGSKDTDVIIWDVINESGLYRLKG-HKDAVTQALFLR-E---RNLLVTSGKDTM--VK----WWDLDNQHCFKTMVGHRTEVW--GLVL
H_sapiens_ENSP00000262715                 TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQITGCCLSP-D---CRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKSLN--CVAF
T_rubripes_ENSTRUP00000017221             QAQCTRSWRAIHTAPVASMDFD--STSTLLATGGCDGTIKIWDVVKQYCTHNLRG-SSGVVHLVQFHP-DIS-RLKLFSSSMDCS--IW----MWDLSTSLCVCMLQSHYSAVT--SLSF
C_intestinalis_ENSCINP00000019387         EVKCVRTWRAIHMFPVVSMDFD--PTSTLLATGGSDGTIKVWDMIRQYCTHNFRG-SPGIVNCVAFHP-N---NLTLYSAADDYN--IR----VWDLNSSKLVKVLNSHVSSVT--CLKF
G_gallus_ENSGALP00000023833               SGEASVAFNG-HKAAVTALQYD--QLGGRLVSGSKDTDVIVWDVINESGLYRLKG-HKDAVTQVLFLK-E---KNLLVTSGKDTL--VK----WWDLDTQHCFKTLVGHRTEVW--GMAL
P_troglodytes_ENSPTRP00000010340          TWQEEKSVVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQITGCCLSP-D---CRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKSLN--CVAF
T_guttata_ENSTGUP00000013749              SGESTITFNG-HRAAVTALQYD--HLGGRLVSGSKDTEVIVWDVINESGLYRLRG-HKDVITQVLFLK-E---KNLLITCAKDTL--VK----WWDLDTQHCFKTLVGHRAEVW--GMAL
T_rubripes_ENSTRUP00000006345             NGESNVSFNG-HKSAVSIICYD--ELGARLVTGSKDTDVIVWDIINECGLYRLRG-HKGLITQALFLK-D---KNLLVTSSKDSF--VK----WWDLDTQHCFKTIVGHRSEVW--GMVL
H_sapiens_ENSP00000308179                 SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDAITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
R_norvegicus_ENSRNOP00000012235           TWQEEKALVS-GCDGISSFAFL---SDTALFLTTFDGLLELWDLQHGCWVFQTKA-HQYQITGCCLSP-D---RRLLATVCLGGY--VK----LWDTVQGQLAFQYT-HPKSLN--CITF
D_melanogaster_FBpp0085899                SNSLDHIFKG-HTAAVTCLLVAPQSDSELLLTGSEDATVLVWHVGLRERRAHIKNAHTAPITGVAAGA-N---NTLIISSSEDAS--IA----ITDLASGKLRHRITHHRGPVS--GIVV
P_troglodytes_ENSPTRP00000001997          SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDAITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
M_mulatta_ENSMMUP00000011166              SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDVIVWDVINESGLYRLKG-HKDAITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
M_domestica_ENSMODP00000006461            SGEGNVTFNG-HKAAVTALSYD--QLGGRLVSGSKDTDVIVWDVINESGLYRLKG-HKDAITQVLFLR-E---KNLLITSGKDTV--VK----WWDLDTQHCFKTMVGHRTEVW--GMVL
P_pygmaeus_ENSPPYP00000001131             SGEGNVTFNG-HKAAITTLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDAITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
M_mulatta_ENSMMUP00000021364              TWQEEKSLVS-GCDGISACLFL---SDDTLFLTAFDGLLELWDLQHGCRVLQTKA-HQYQITGCCLSP-D---RRLLATVCLGGC--LK----LWDTVRGQLAFQHT-YPKPLN--CVAF
B_taurus_ENSBTAP00000026561               SGEGNVTFNG-HKAAITSLKYD--QLGGRLASGSKDTDIIVWDVINESGLYRLKG-HKDAITQALFLR-E---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
R_norvegicus_ENSRNOP00000026726           SGEGNITFNG-HRAAVTSLKYD--QLGGRLASGSKDTDVIIWDVINESGLYRLKG-HKDAVTQALFLR-E---RNLLVTSGKDTM--VK----WWDLDNQHCFKTMVGHRTEVW--GLVL
A_gambiae_AGAP009615-PA                   KHTVQKMWKTVHQGPISRLVFS--PTDSVIASGGSDSTIRLWDPTEQVCLGTLRG-AEGLINVIVFHP-DAD-SKIVVAVGDDTK--IR----AWDYESRKQVKTFEGHFSRVT--GVSF
B_taurus_ENSBTAP00000027147               EGSVTRLWKAIHTAPVATMAFD--PTSTLLATGGCDGAVRVWDVVRCYGTHHFRG-SPGVVHLVAFHP-DPA-RLLLFSSAADTS--IR----VWSLQERSCLAVLTAHYSAVT--SLTF
X_tropicalis_ENSXETP00000035244           SGEEVRILHS-GCDGVSACNFI---SDDLLCVGSYDGILEIWKISDGCRMHRAEA-HRRQITGCCVSP-D---QRQLITCSLDYQ--LK----LWETSRGSLLGSIS-FPYPLA--CTTF
A_aegypti_AAEL004364-PA                   SKQSVCTFSA-HRSAVSAMNFD--LIGLKLVSGGLDNDLVVSDVVAQSGKCRLVG-HNGAITEACFMERY---HDVVVSSSKDTQ--IK----FWNIETQSCFKTIVDHRTEVW--GIAL
O_anatinus_ENSOANP00000004860             SGENTVTFNG-HKAAVTALKYD--HLGGRLVSGSKDTDVIVWDVINESGLFRLKG-HKDAVTEALFLR-E---RDLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLAL
E_caballus_ENSECAP00000005446             SGEGNVTFSG-HKAAITSLKYD--QLGGRLASGSKDTDVIVWDVINESGLYRLKG-HKDAITQALFLR-G---KNLLVTSGKDTM--VK----WWDLDTQHCFKTMVGHRTEVW--GLVL
S_cerevisiae_YLR222C                      TGKVVRSMKI--SSPSYILDAD--STSTLLAVGGTDGSIIVVDIENGYITHSFKG-HGGTISSLKFYG-QLN-SKIWLLASGDTNGMVK----VWDLVKRKCLHTLQEHTSAVR--GLDI
E_caballus_ENSECAP00000009299             TWQEEKSVVS-GCDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCRVLQTNA-HQYQITSCCLSP-D---NRLLATVCLGGC--LK----LWDTVRGQLAFQHT-CPKPLN--CVAF
X_tropicalis_ENSXETP00000021860           SGESGITFNG-HKAAVTALNYD--HLGGRLVSGSKDTDVIVWDVINESGLYRLRG-HKDAITQALFLR-E---KNLLISSGKDTL--VK----WWDLDTQHCFQTMVGHRTEVW--GLTL
A_gambiae_AGAP004827-PA                   SNSLVHTFKG-HSGPITYMKVL----SQYLVTASEDTSVIVWDMKTLAMKLRLRE-HIAPALCATLAL-D---NKYVISGSDDSS--II----VSLLETGKLVTKFDHHRGPVS--ALHM
M_domestica_ENSMODP00000027702            EGNATRVWKAVHTAPVASMAFD--PTSTLLATGGCDGAVRVWDLERRYGTHHLRG-SPGVVHLLAFHP-DPE-QLLLFSSAMDCT--IR----VWGLQAGTCLAMLSSHYSTVT--SLAF
X_tropicalis_ENSXETP00000015707           QGTCSRTWKAIHTAPVATMTFD--PTSTLLATGGCDSTIKIWDVIKQYCTHNLKG-SSGVVHLVQFHP-DMS-RLQLFSSSMDYK--IR----LWDLKTSKCLCVMETHFSAVT--SLCF
M_mulatta_ENSMMUP00000010429              EGSVTRLWKAIHTAPVATMAFD--PTSTLLATGGCDGAVRIWDIVRHYGTHHFRG-SPGVVHLVAFHP-DPT-RLLLFSSAADAA--IR----VWSLQDRSCLAVLTAHYSAVT--SLTF
B_taurus_ENSBTAP00000001564               TWQDERSMVS-GGDGVSSCSFL---SDNALFLTAFDGLLELWDLQHGCRVLQIQA-HQYQITGCCLSP-D---RRLLATVCLGGG--LK----LWDVVRGQLASQHT-CPKPLN--CVAF
A_aegypti_AAEL001276-PA                   SNSLVHTFKG-HSGPVTYMKVQ----WQYLLTASEDTSVIVWDMQTLALKLRLCE-HIAPVTCCTLAL-D---NKYLITSSEDSS--II----VALFESGKVITKIDHHRGPVT--AIHV

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                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------SPDDKLLASCSADGTLKLWDATS--ANE-------------------------------------------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK
P_troglodytes_ENSPTRP00000042795          ------SPDDKLLASCSADGTLKLWDATS--ANE-------------------------------------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIIVAAKNK
P_pygmaeus_ENSPPYP00000005543             ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------------------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIMVAAKNK
M_mulatta_ENSMMUP00000038848              ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------------------------RKSFNVKQFFLNSEDPQEDMEVIVKCCSWFADGARIMVAAKNK
E_caballus_ENSECAP00000022364             ------SPDDKLLASCSADGSLKLWDVKS--ANE-------------------------------------------RKSINVKQFFISSEEPQEDMEVIVKCCSWSSDGARIMVAAKNK
B_taurus_ENSBTAP00000028867               ------SPDDQVLASCSADGTLKLWDVKS--ANE-------------------------------------------RKSINVKQFFLNSEEPQEDLEVIVKCCSWSADGAKIMVAAKNK
C_familiaris_ENSCAFP00000009806           ------SPDDKLLASCSADGTLKLWDVKS--ANE-------------------------------------------RKSINVKQFFLNSEEPQEDMEVIVKCCSWSADGTRIMVAAKNK
M_musculus_ENSMUSP00000020157             ------SPDDELLASCSADGTLRLWDVRS--ANE-------------------------------------------RKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNK
O_anatinus_ENSOANP00000008896             ------SPDDKYLASCSADGTLKLWEVAS--ANE-------------------------------------------WKSIDVSKFFQTSEH-EEDVEVLVKCCSWTTDGATIMVTAKNM
M_domestica_ENSMODP00000009538            ------SPDDTHLASCSADGTLKLWDVSS--ANE-------------------------------------------CSSIDVKQHFLTGDGRQDDVDVVVKCCSWSNDGARLMAAAANR
R_norvegicus_ENSRNOP00000010869           ------SPDDELLASCSADGTLKLWDVRS--ANE-------------------------------------------KKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDRIIVAAKNK
T_guttata_ENSTGUP00000009081              ------SPNDEYVASCSTDGTVKLWESRS--GNE-------------------------------------------LKSIEIKDFFKNADEQPDDVEVLVKCCSWSRNGDKILVVAKNK
G_gallus_ENSGALP00000037436               ------SPNDDYIASCSTDGTVKLWNVHS--ANE-------------------------------------------LRTIEIKDFFRNADEQQDDVEVLVKCCSWSRSSDTILVVAKNK
A_carolinensis_ENSACAP00000012965         ------SPNDKYIASCSADGTLMLWYAQS--ANK-------------------------------------------RKTVDIRGNFRNVDEYQDDMEVLVKCCSWSSDSTTIVVAAKNK
G_gorilla_ENSGGOP00000008216              ------SPDDKLLASCSADGTLKLWDVTS--ANE-------------------------------------------RKSINVKQFFLNSEDPQEDMEVIVKCCSWSADGARIMVAAKNK
X_tropicalis_ENSXETP00000014654           ------SPDDRYLASSSMDGSLKIWDVES--ANE-------------------------------------------EKSIEVAKLFENEDEAQP--EVLLKCCAWSNDGSRIMVTARNF
O_cuniculus_ENSOCUP00000010200            ------SPDDKLLSSCSADGTLKLWDVKS--ANE-------------------------------------------VKSINVKKFFLTSEDPQEDMEVIVKCCSWSADGARIMVAAKNK
D_rerio_ENSDARP00000008347                ------SPNDLYLATSSSDGSLKLFEVSS--ANE-------------------------------------------WKSIDVDSFFPESDE---EIKAMVKCSTWSADGSQIICAARNT
T_rubripes_ENSTRUP00000033561             ------SPDDAIVSTSSNDGTVKLFRASS--ANE-------------------------------------------WKTISVRDQVAENDE-----EVLVKCSTWTADGKRIICAARNA
T_nigroviridis_ENSTNIP00000013938         ------SPDDTYVSTASNDGTVKLFQVSH--ANE-------------------------------------------WKTINVRKRLTENDE-----EVLVKCSTWTADGKQLICAARNA
G_aculeatus_ENSGACP00000026214            ------SPSDTYLSTSSNDGTVKLFHTSS--ANE-------------------------------------------WKTINVRDAFAESDE-----EVLVKCSTWTADGKRIICAARNA
O_latipes_ENSORLP00000019346              ------SPDDNYVSTSSNDGTVKLFEATS--GNI-------------------------------------------WKSIDVRGMFKDPDN---DDEVAVRCSSWTADGKRILCAARNA
C_elegans_Y45F10B.10                      ------TSNNQFLITGSGDFVVQMWDVTN--GKC--------------------------------------------------------ISRMGGLMAPVSTLAITSNDAFVVVACEDE
C_intestinalis_ENSCINP00000010464         ------TPDERRIITGSGDSELRIWSVEF--IAN--KDSMEA--PLVKLQKT-KLDDVTSNDVTSDDVISDDV-MQGIEERLVSCIKVGSVMRKGR--DRVVTLKVSKDGRLLTCHGNDK
O_latipes_ENSORLP00000010395              ------LKQEKRLLTGSADSELRAWDIAA--LEE--IEDKTEGGPKVKKGKT---LLEEDED--DEEE---KE-DESLDERILSCKKAGSILREAR--DRVVSMTTDSRARVVACHGNDS
T_nigroviridis_ENSTNIP00000007980         ------LDQDNRLLTGSADSELRAWDITY--LQE--IDESPE--EVQKPLSS----VLSRLL--AHPL---SL-PPPSLQRILSCHKAGSILREAR--DRVVSLTTDARSAVIACHANES
T_guttata_ENSTGUP00000006840              -------ADGNSLLSSGRDKICMVWDLET--RQS-------------------------------------------KRTIPVYETVEAAVLLPEK--GDFSQLGVKKQGLHFVTAGSKG
T_nigroviridis_ENSTNIP00000004057         ------SLDGDTMVSSGRDKICTVWDLKQ--QKA-------------------------------------------KRTIPIYEAVEGAVILPEN--QDFSQIGVKKPKLHFITAGSKG
M_domestica_ENSMODP00000008927            ------HPEEQVITTGNWAGCLSVLRLDS--LTV------------------------------------------------------TMFIGLKGSESSVRAVTFAPSGTVLAASHLDG
D_rerio_ENSDARP00000023281                ------LNQENRLLTGSADSELRAWDIQD--IEE--VKELGE--PQEKKVRT----LLEDEE--EDEE---GP-DEEPEERILSCKKAGSILREAR--DRVVSLVTDAKAKVLACHGLDA
G_gallus_ENSGALP00000008904               ------TADGNTLISSGRDKICMVWNLKT--RES-------------------------------------------IRTIPIYESVEAAVLLPEQ--GDFSQLGVKKQGLHFLTAGSKG
G_aculeatus_ENSGACP00000015863            ------TPDGDTMVSSGRDKICTVWDLKT--RKA-------------------------------------------TRTVPVYETVEGVVLLPDD--EDLSDIGVTSKNLHFITAGSKG
A_aegypti_AAEL004526-PA                   ------TSDHKFLVSSGRDKILIMWNYET--QQA-------------------------------------------VKTIPVYESLESVIVLPKG--VHLPGLKLKSDKVYAACAGEEG
M_musculus_ENSMUSP00000060613             ------VSEEKRLITGAADSELRAWDIDY--LQE--IDDPEE--PEPKKIKE--CPGIQDTP--ESEDSTLEADDEKSEDRILSCSKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS
H_sapiens_ENSP00000262715                 ------HPEGQVIATGSWAGSISFFQVDG--LKV------------------------------------------------------TKDLGAPG--ASIRTLAFNVPGGVVAVGRLDS
T_rubripes_ENSTRUP00000017221             ------SPDGDTMISSGRDKICTVWDLKQ--QNA-------------------------------------------KRAIPVYEAVEGVIFLPEN--QDFSQIGVKNPKLHFVTAGSKG
C_intestinalis_ENSCINP00000019387         ------S-NVDCLVSAGRDNVVCLWNVKEGGNEP-------------------------------------------YKVIPVFESVEACFNFERK--EN-------ETGFLIITAGSKG
G_gallus_ENSGALP00000023833               ------VSEEKRLITGTADSELRVWDITY--IQE--LEDPDE--PESKKSKG-SSPGAEKD---NEEDETLEL-DESPEERLLKCSKAGSIMREGR--DRVVTLATDRMGKILACHGTDA
P_troglodytes_ENSPTRP00000010340          ------HPEGQVIATGSWAGSISFFQVDG--LKV------------------------------------------------------TKDLGAPG--ASIRTLAFNVPGGVVAVGRLDS
T_guttata_ENSTGUP00000013749              ------LSKEKRLITGSADSELRVWDLTY--IQE--VKDHDE--PESKKSKGSSSPGAEEN---NEEDETLEV-DEHPEERIVKCSKVGSIMREGR--DRVVTLGTDRMGKFLAVHGTDT
T_rubripes_ENSTRUP00000006345             ------LDRESRLLTGSADSELRAWDITY--LQE--VKAEGE--PEEKRGKI---ELVEDEDEGDQED---EA-DEGPEERILSCKKVGSILREAR--DRVVSLAADARTGVIACHGNDS
H_sapiens_ENSP00000308179                 ------LSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG-SSPGIQDTL--EAEDGAFET-DEAPEDRILSCRKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS
R_norvegicus_ENSRNOP00000012235           ------HPEGQVVATGNWSGIVTFFQADG--LKV------------------------------------------------------TKELGGPG--PSVRTLAFSAPGKVVALGRIDG
D_melanogaster_FBpp0085899                ------AGACDVLISGGLDRTICVWDLDN--FTL-------------------------------------------LNTMQMT--------------SAVLRIDISWNSVFLLALCEDN
P_troglodytes_ENSPTRP00000001997          ------LSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG-SSPGIQDTL--EAEDGAFET-DEAPEDRILSCRKAGSIMREGR--DRVVNLGVDKTGRILACHGTDS
M_mulatta_ENSMMUP00000011166              ------VSEEKRLITGASDSELRVWDIAY--LQE--IEDLEE--PDPKKIKG-SSPGVQDTL--EAEDGTFEM-DEAPEDRILSCRKAGSIMREGR--DRVVNLAVEKTGRILACHGTDS
M_domestica_ENSMODP00000006461            ------VSEEKRLITGSADSELRAWDITY--IEE--LKDLGE--PNSKKSRG-SSLGTQENH--ETETGDPGV-DEDPEDRILSCNKAGSIMREGR--DRVVNLAIDRTGRILACHGTDS
P_pygmaeus_ENSPPYP00000001131             ------VSEEKRLITGASDSELRVWDIAY--LQE--IEDPEE--PDPKKIKG--SPGIQDTL--EAEDGAFET-DEAPEDRILSCTKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS
M_mulatta_ENSMMUP00000021364              ------HPEGQVIATGSWAGSISFFQVDG--LKV------------------------------------------------------TKDLGAPG--ASVRTLAFNVPGGVVAVGRLDS
B_taurus_ENSBTAP00000026561               ------VSEEKRLITGASDSELRAWDISY--LQEKQIEDPEE--PEPKKIKE-SSPGIQDSH--EAEDGTLEM-DETPEDRILTCRKAGSIMREGR--DRVVNLAVDKTGRILACHGTDS
R_norvegicus_ENSRNOP00000026726           ------VSEETRLITGAADSELRAWDIAY--LQE--IDDPEE--PEPKKIKE--CPGIQDTP--EAEDRTLEADDEKSEDRILSCRKAGSLMREGR--DRVVNLAVDKTGRILACHGTDS
A_gambiae_AGAP009615-PA                   ------SEDRTHLVSAGRDKILILWNFES--QQA-------------------------------------------VKTIPVYETLESVVVLP---------------------AGLRG
B_taurus_ENSBTAP00000027147               ------SADGHTMLSSGRDKICVIWDLRS--LQA-------------------------------------------TRTVPVFESVEAAVLLPEE---PAPELGVKSAGLHFLTAGDQG
X_tropicalis_ENSXETP00000035244           ------HPRGHVVAVGSWDGKITVLRLEN--WEK------------------------------------------------------TAVL-CGS--SSVRTVSFSQDGKWLISGSLDG
A_aegypti_AAEL004364-PA                   ------MRNDDFLVAGSGDTQLAVYKIAE--NTS--------------------------NAVEEPTGDLGDLLLESEATSPFRCTQIGNIQRSGF--GRTINLVVENNGQILGCHGTDK
O_anatinus_ENSOANP00000004860             ------VSDDRRLITGAADSELRAWDITW--AQGAQPRDPAE--PDAKRARG-PPPATPGEP--QEEE------DEAPEERILSCTKAGSIMREGR--DRVVGLAADRTGTVLACHGSDS
E_caballus_ENSECAP00000005446             ------VSEEKRLVTGTSDSELRAWDIAY--LEE--IEDPEE--PEPKKIKG-PSSGIQDTH--EAEDGALET-SEAPEDRILTCRKAGSIMREGR--DRVVNLAVDRTGRILACHGTDS
S_cerevisiae_YLR222C                      IEVPDNDEPSLNLLSGGRDDIINLWDFNM--KKK----------------------------------------CKLLKTLPVNQQVESCGFLKDG-----------DGKRIIYTAGGDA
E_caballus_ENSECAP00000009299             ------HPEGQVVAIGSWSGSFSFFQVDG--LKV------------------------------------------------------TKELGAPG--ASVRTLAFNVPGQVVAVGRLDR
X_tropicalis_ENSXETP00000021860           ------LSEESRVLTGSADSELRAWNISY--MKE--TEDTDG--PQSKKSKG---PLGEAQ---EEEE---DV-EESTEGRILSCQRFGSIMREGR--DRVVSLGTDRTRRFLACHGADS
A_gambiae_AGAP004827-PA                   ------SYPSEVLVSSSHDATVCLWSLEN--FTL-------------------------------------------LNCIQMS--------------QPILNMQISCDSTFLLAHCADN
M_domestica_ENSMODP00000027702            ------SDDGHTMVSSGRDKICTVWDLKT--RTS-------------------------------------------VKTVPVFESVESVVLLPKG--GD-PELGVNTPGLHLLTAGDRG
X_tropicalis_ENSXETP00000015707           ------SPDGNTMISSGRDKICTVWDLET--KSP-------------------------------------------KRTVPVYESVEAVVLFPDS--SDIICQENDSQSLLFLTAGSKG
M_mulatta_ENSMMUP00000010429              ------SADGHTMLSSGRDKICVIWDLQS--CQA-------------------------------------------TKTVPVFESVEAAVLLPEE---PVSQLGVKSSGLYFLTAGDQG
B_taurus_ENSBTAP00000001564               ------HPEGQVIAVGGWAGSFSFFHVDG--LRV------------------------------------------------------TKELGAPG--ASVRTLAFGVPGRVVAVGRLDR
A_aegypti_AAEL001276-PA                   ------AMPSEVLVSSSHDGTVCLWSLDN--FTL-------------------------------------------LNCIQLP--------------HPVLNFQISCDSIFLLAYCEDN

                                                 2170      2180      2190      2200      2210      2220      2230      2240      2250      2260      2270      2280
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 I------------------------------------------------------------------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW
P_troglodytes_ENSPTRP00000042795          I------------------------------------------------------------------------FLFDIHTSGLLGEI-HTGHHSTIRYCDFSPQNHLAVVALSQYCVELW
P_pygmaeus_ENSPPYP00000005543             I------------------------------------------------------------------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW
M_mulatta_ENSMMUP00000038848              I------------------------------------------------------------------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW
E_caballus_ENSECAP00000022364             I------------------------------------------------------------------------FLVDVHTCGLLAEI-HTGHHSTIQYCDFSPSNHLAVVALSQYCVELW
B_taurus_ENSBTAP00000028867               V------------------------------------------------------------------------FLFDIHSSGLLAEM-HMGHHSAVQYCDFSPHNHLAVVALSQYCVELW
C_familiaris_ENSCAFP00000009806           I------------------------------------------------------------------------FLFDIHTGGLLAEI-HTGHHSTIQYCDFSPQNHLAVVALSQCCVELW
M_musculus_ENSMUSP00000020157             V------------------------------------------------------------------------LLFDIHTSGLLAEI-HTGHHSTIQYCDFSPYDHLAVIALSQYCVELW
O_anatinus_ENSOANP00000008896             I------------------------------------------------------------------------FLFDVKTSGLSAEI-QTSHHSTIQYCDFYPCSHLAVVALSHYCVELW
M_domestica_ENSMODP00000009538            L------------------------------------------------------------------------LVFDVQSRNLLGEI-HTSHSSTIRFCDFFPKSHLAAVALSHYCVELW
R_norvegicus_ENSRNOP00000010869           V------------------------------------------------------------------------LVMETQSSGKSSHC-FSLLRRPLRIYFLNPFDNLMLIDSSKFAVQLL
T_guttata_ENSTGUP00000009081              L------------------------------------------------------------------------LLFDINTCGLLTQV-IVSHHSTIQYCDFCPGDELVAVALSHCSVELW
G_gallus_ENSGALP00000037436               L------------------------------------------------------------------------LLFDVTTSNLLTQV-IISHHSTIQYCDFCAGDELVAVALSHCSIELW
A_carolinensis_ENSACAP00000012965         L------------------------------------------------------------------------FRTDTKISTSLPEV-LINHHYTIQYCDFCPNSQMVAVALSNYSVEIW
G_gorilla_ENSGGOP00000008216              I------------------------------------------------------------------------FLFDIHTSGLLGEI-HTGHHSTIQYCDFSPQNHLAVVALSQYCVELW
X_tropicalis_ENSXETP00000014654           L------------------------------------------------------------------------CIYDAERCNLLSQL-KACHQ--ILYCDFCTTNQIAALALSHYVVQLW
O_cuniculus_ENSOCUP00000010200            I------------------------------------------------------------------------LXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLW
D_rerio_ENSDARP00000008347                V------------------------------------------------------------------------FVFDVETSDLLLEL-KTSRLSTIQFCHACPNSSLLAVALSHYTVELW
T_rubripes_ENSTRUP00000033561             V------------------------------------------------------------------------LVFDVETSDMLLEI-KTSRLSMVQYCHACPTSNLLAIAFSNYAVELW
T_nigroviridis_ENSTNIP00000013938         V------------------------------------------------------------------------LVFDVETSDLLSEI-KTSRLSTVQYCHACPTNNLLAIAFSNYAVELW
G_aculeatus_ENSGACP00000026214            A------------------------------------------------------------------------LVFDVETSDMLLEI-RTNRLSTVQYCHACPTSNLLAIAFSNYAVELW
O_latipes_ENSORLP00000019346              A------------------------------------------------------------------------LMFDVETSDLLLEI-RPSFLSTVLHCDVCPTSNLLAMALSNYAVELW
C_elegans_Y45F10B.10                      TLKVFSTVGGQELHELMGHEG---------------------KVNSLVCAQDDCQLFAATKSKV---------FCYDIHNGQMIDVLDTAQPFPICSLKI--SSDNYFLISPCGPKVTIW
C_intestinalis_ENSCINP00000010464         MVEFFRIFDEAEVALRIKK-----------------------KLKRAKKKQK------NEGQEENDI----TIERSIEDEISHVGSFTCAGKLSSLDLTAPTPNTYNTVALLRNNQIETV
O_latipes_ENSORLP00000010395              VLELFTVLTEEEVQRKMTK-----------------------KMKKARKKAAKTSALEEAGGAAAEP----VVERTLKDEIVRLTNIKASAKIRWADCLSGAGGELKVALLLQNNTVETY
T_nigroviridis_ENSTNIP00000007980         VLELFRVLPEVEVQQKMKK-----------------------KEKKAKKKAAQAP--EDAAEDAGTP----AVTRTLKDEIVRLTNIKASAKIRWAECVWCSGGELKVALLLQNNTVETY
T_guttata_ENSTGUP00000006840              VLRVWDVATAACVHSQAVPFT------------LREEPSEH-SLSQC-----QNEILTVSMEHNI--------VFYDAHSLQLRKQL-TGYNEEVLDVKFLGPGDSHIVVATNSPQLKVF
T_nigroviridis_ENSTNIP00000004057         ILRVWDPNTARCVFSQTLTGVSAA-------------DNPR-SLTHLLLLPASLRLATVTAEHNI--------MLYQLPGLTTLQQF-VGYSDEVLDVKFLGKDDSHIVVATNSCQLNVF
M_domestica_ENSMODP00000008927            TVELWAWQKGAQLASFPAHLG---------------------YVASALFLQSGRQMLTAGEDGKV--------QMWSGSLGRPKGTL-DSLPLSPALSVAISPDRAFVAVGHHSDGIRIY
D_rerio_ENSDARP00000023281                TLEVFTVLSEEEIQRKMDR-----------------------KLKKAKKKAKS----QEGGEEASEP----VVERKLKDEIMKLANIRASSKIRSMDCLLVPNGEMKVVLLLQNNTVETY
G_gallus_ENSGALP00000008904               VLKVWEVATAACVYSQPVPFEPVE---------SEEEASEH-SLTHCMLVPERNEIVTVSVEHNI--------VFYDAQTLQLRKQL-AGYNDEVLDVKFLGPGDSHIVVATNSPQLKVF
G_aculeatus_ENSGACP00000015863            VLRVWEASTARCVYAQTLNSTLAAVSE---KEEEKDDDNDHCSLTYLLLLPASSRLATVTADHNI--------VLYQLPALTTQQQF-VGYNDEVLDVKFLGKGDSHIVVATNSCQLKVF
A_aegypti_AAEL004526-PA                   LIKVWEMTETKIVFKQKNSLVT-----------KSAEEGGL-AITDLLFNKQSSKLAIVSADHNI--------IIHDLETFECSKQL-SGFSDEILDLILFGKKDHFLGMATNSNDFKIY
M_musculus_ENSMUSP00000060613             VLEVFCILSKAEVQKKMDK-----------------------KLKKARKKARLNS--AN-EEEDPET----SVSMTLQDEILRVAKIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY
H_sapiens_ENSP00000262715                 MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAGEDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY
T_rubripes_ENSTRUP00000017221             ILRVWDPNTARCVFSQTLGTVSVKKDDEEGEEEEKKDDNPR-SLTHLLLLPASSRLATVTAEHNI--------TLYQLAGLTTLQQF-VGYNDEVLDVKFLGKDDSHIVVATNSCQLKVF
C_intestinalis_ENSCINP00000019387         QLRVWESSNGKCVFTNP----------------DNDSNVAS-GYIHAKLIPDTNKMVAVTFDHCI--------DCLDMNGLVVNKQM-VGYNDEIVDLKLLGKNDSHIIVVTNSPHIKVF
G_gallus_ENSGALP00000023833               VLEVFSVLSEEEIKKKLDK-----------------------KMKKAKKKAKKKS-----EEDEHKG----NVELSLQEEIQRVTNIRASAKIKSFDMILSPKEELKIVLLLQNNIIELY
P_troglodytes_ENSPTRP00000010340          MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAGEDGKV--------QVWSGSLGRPRGHL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY
T_guttata_ENSTGUP00000013749              VLEVFSVLSEEEIQKKLGK-----------------------KLKKARKKAKQNS------EEEPER----SVELSLQEEIQRVTNVKASSKIKSFDLILSPKGELKMVLLLQNNIIELY
T_rubripes_ENSTRUP00000006345             ILEVFRVLPEAEVQQKMKK-----------------------KEKRARKKAARAQ--EETGEDAGEL----TVKRTLKDEITRLTHIKASAKIRWAECLSCPGGELKVALLLQNNTIETY
H_sapiens_ENSP00000308179                 VLELFCILSKKEIQKKMDK-----------------------KMKKARKKAKLHS--SKGEEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELY
R_norvegicus_ENSRNOP00000012235           TVELWAWQEGTRLAAFPAQCG---------------------GVSTVLFLHAGGRFLTAGEDGKA--------QLWSGFLGRPRGCL-GSLYLSPALSVALNPDGDQVAVGYRGDGIKIY
D_melanogaster_FBpp0085899                ALYVRTLATGKELHTLKGHKS---------------------KIRSISIGKDSQRCVVGCDDTRA--------LIYDMHAGKLVRSL-PPNPGPVTAVHAMDNDDFLVTVG--GNKITFY
P_troglodytes_ENSPTRP00000001997          VLELFCILSKKEIQKKMDK-----------------------KMKKARKKAKLHS--CKGEEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY
M_mulatta_ENSMMUP00000011166              VLELFCILSKEEIKKKMDK-----------------------KMKKARKKAKLHS--CKGEEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY
M_domestica_ENSMODP00000006461            ILEVFCILSKEEIQKKMDK-----------------------KIKKARKKAKLSS--GEGEQEDSGV----SVVMSLQDEIQRVANIKASAKIKSFDLIHSPHGGLKAVFLLQNNLVEVY
P_pygmaeus_ENSPPYP00000001131             VLELFCILSKEEIQKKMDK-----------------------KMKKARKKAKLHS--CKGEEEDPEV----NVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY
M_mulatta_ENSMMUP00000021364              MVELWAWREGARLAAFPAHHG---------------------FVAAALFLHAGCQLLTAGEDGKV--------HVWSGSLGRPRGDL-GSLPLSPALSVALSPDGDRVAVGYRADGIRIY
B_taurus_ENSBTAP00000026561               VLEVFCILSKEEIQKKMDK-----------------------KMKKAKKKAKLNS--CNEEEEDLEV----NVKMTLQDEIQRVANIKTSAKIKSFDLIHTPQGELKAVFLLQNNLVELY
R_norvegicus_ENSRNOP00000026726           VLEVFCILSKAEVQKKMDK-----------------------KLKKARKKARLNS--AN-EEEDPET----SVSMTLQDEILRVTKIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELY
A_gambiae_AGAP009615-PA                   LIKVWEMTGAKIIFKQSNSLVA-----------KAAEEGGL-AITHLFYSEPHGRMAVVSADHNI--------LVHDCESFDYVHQL-SGFSDEILDLILFGKRDQHIAMATNSSDFKVY
B_taurus_ENSBTAP00000027147               ALRVWEAASGRCVHAQ-----------------QRLRGPGR-ELTHCTLAHAAGLLLSVTADHNL--------LLYDAHSLRLRKQF-AGYSEEVLDVRFLGPEDSHVVVASNSPCLKVF
X_tropicalis_ENSXETP00000035244           WVSLWAWEAQVQLSHFKAHSG---------------------STLTCSFLQQGKYLLTGGEDSKV--------QVWSGGLGRLLGRVDGEIKNSSAISLAVSPSRQLLAVGYHTGTVSVY
A_aegypti_AAEL004364-PA                   KIELFYFYSVDEALVRLTK-----------------------RLKKLDAKSKADD----TNANANLA----ERQLSLVDEIKRLPAISVPEKVKSFDLLLGSNDELRICVTFVKNFIQVF
O_anatinus_ENSOANP00000004860             VLELFRVLSEEEIQKKIDK-----------------------RMKLARKKAKRVE--RAGRRRPPQRSFPAVSPVTLQDQIRRMVNVKASAKIKSFDLIRGPRGEVKAALLLQNNQVELV
E_caballus_ENSECAP00000005446             VLEVFCILSGEEIQKKKDK-----------------------KMKKARKKAKLSS--CKGEEEDLEV----SVEMTLQDEIQRVTNIKTSAKIKSFDLIHSSQGELKAVFLLQNNLVELY
S_cerevisiae_YLR222C                      IFQLIDSESGSVLKRTNKPIEEL-------------------FIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSI-AGNHGIIADMRYVGPELNKLALATNSPSLRII
E_caballus_ENSECAP00000009299             MVELWAWKEGARLAAFPAHHG---------------------FVAAALFLRAGCQLLTAGEDGKV--------QVWSGSLGRPRGCL-GSLSLSPALSVALSPDGDRVAVGYRADGIRIY
X_tropicalis_ENSXETP00000021860           VLEVFCALNEEEIAKKMEK-----------------------KLKRAKKKAKQKS---EDAEEEEEL----KVERCLQDEIQRLGNIKASSKIKSFDLFAGAKGELKAVLLLQNNSLECY
A_gambiae_AGAP004827-PA                   GLYLRSLTTGTELHALKGHKS---------------------KVRALCIAMDSQRAIVGGEDTRA--------LIFDMHSGRVIRSL-PPNPGAVTAVYVMEKDDYLITAG--GNKITFY
M_domestica_ENSMODP00000027702            VLRIWEVESGSCVYTQKPV--------------AGEGGPGR-EITHCALVPAAGLIMAVTAEHNI--------LLYDAHNLRLHKQF-AGYNEDVLDVRFLGPEDSHIVVATNSPRLKVF
X_tropicalis_ENSXETP00000015707           ILRVWDAATAVCVYGQTLPHIAEGNS-------TEEEANEH-SLTHCLLIPGQHQVATVTAEHNI--------LMYDLQNLQLKKQF-AGYNDEVLDVKFLGPSDSHIVVATNSPQLKVF
M_mulatta_ENSMMUP00000010429              ILRVWEAASGQCVYTQ-----------------ARPPGPGR-ELTHCTLARTAGLLLSATADHNL--------LLYEARSLRLQKQF-AGYSEEVLDVRFLGPEDSHVIVASNSPCLKVF
B_taurus_ENSBTAP00000001564               MVELWAWQEGARLAAFPAHQG---------------------FVATALFLRSGCQLLTAGEDGKV--------QVWSGSLGRPRGCL-GSPHLSPALSVALSPDGDQVAVGYRADGIRIC
A_aegypti_AAEL001276-PA                   GLYLRALATGTELHALKGHKS---------------------KVRALCIAMDSQRAIVGGEDTRA--------LIYDMHSGRIIRSL-PPNPGPVTAVYIMAKDDYLITAG--GNKITFY

                                                 2290      2300      2310      2320      2330      2340      2350      2360      2370      2380      2390      2400
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 NTDSRS---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN
P_troglodytes_ENSPTRP00000042795          NIDSRS---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN
P_pygmaeus_ENSPPYP00000005543             NIDSRS---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN
M_mulatta_ENSMMUP00000038848              NIDSCS---------K------------VAD-------------------------------CRGHLSWVHGVKFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAIMLKQEVDVVFQEN
E_caballus_ENSECAP00000022364             NMDSCL---------K------------VAD-------------------------------CRGHLSWVHSVMFSPDGSSFLTSS-DDETIRLWE-TKKVCKNSGIVLKQEIDVLFQEN
B_taurus_ENSBTAP00000028867               SMDSGL---------K------------VAD-------------------------------CRGHLSWVHCVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSATVLKQEIDVVFQEN
C_familiaris_ENSCAFP00000009806           NMDSCL---------K------------VAD-------------------------------CRGHLSWVHCVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAIVLKQEIDVVFQEN
M_musculus_ENSMUSP00000020157             NIDSRL---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTAS-DDQTIRVWE-TKKVCKNSAIVLKQEIDVVFQEN
O_anatinus_ENSOANP00000008896             NTDSCL---------K------------VAD-------------------------------CRGHLSWVHCVTFSPDGSSFLTSS-DDQTIRVWD-TSKVCKNSAVMLKQEIDVVFRDN
M_domestica_ENSMODP00000009538            NTDTGL---------K------------VAD-------------------------------CRGHLSWVHCVAFSPDGSSFLTSS-DDQTIRLWE-TRKVCKNSAIMLKQEVDVAFRDD
R_norvegicus_ENSRNOP00000010869           HHTIRL---------S------------FNG-------------------------------CEPGLSSLMSQLFWMTDSTQLFLV-PLSLTQVWE-TRKVCKNSAIVLKQEIDVVFQEN
T_guttata_ENSTGUP00000009081              NIKSLS---------K------------VAY-------------------------------CRGHMSWVHCVTFSPDGSLFLTSS-DDQTIRIWE-TKKVCKSSDAVLKSELDVVFHNG
G_gallus_ENSGALP00000037436               NIKSLS---------K------------VAD-------------------------------CRGHTSWVHCVTFSSDGSLFLTSS-EDQTIRIWE-TNKVCKSSDAVLKSELDVVFHNG
A_carolinensis_ENSACAP00000012965         NIESCS---------K------------IAD-------------------------------CRGHMSWVHSVTFSFDGSLFLTSS-DDQTIRIWE-TSKVCNFSAIVLNREIDVLFLDS
G_gorilla_ENSGGOP00000008216              NIDSRS---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRLWE-TKKVCKNSAVMLKQEVDVVFQEN
X_tropicalis_ENSXETP00000014654           DIDSST---------K------------IAD-------------------------------FNAHLSWVHCVKFSPKSSSFLTSS-DDQTVKLWE-TSNVSKPAATNLKREFDVTFSGE
O_cuniculus_ENSOCUP00000010200            NMDSRL---------K------------VAD-------------------------------CRGHLSWVHGVMFSPDGSSFLTSS-DDQTIRVWE-TKKVCKNSAIVLKQEVDVVFQEN
D_rerio_ENSDARP00000008347                NFESSK---------K------------KAE-------------------------------CSGHLSWVHCVQFSPDGSLLLSSS-DDQTIRLWE-TDRVHTSSAVALKRDTDVLFSHS
T_rubripes_ENSTRUP00000033561             DLEANK---------K------------MAD-------------------------------CSGHLSWVQRVQFSPDGSQLLSCS-DDHTVRLWE-TTKVHTSSAVCLKRDSDVLFDQE
T_nigroviridis_ENSTNIP00000013938         DLEANK---------K------------MAD-------------------------------CSGHLSWVQLVQFSTDGSQLLSCS-DDQTIRLWE-TTKVHTSSAICLKRDSDVLFDQE
G_aculeatus_ENSGACP00000026214            DLEANK---------K------------MAD-------------------------------CSGHLSWVQRVQFSRDGSQLLSCS-DDQTVRLWE-TNKVHTTSAVCLKRDSDVLFNDE
O_latipes_ENSORLP00000019346              DIEENA---------K------------KAD-------------------------------CSGHLSWVERVQFSRDGSQMLSCS-DDETIRLWE-TKKLHMTSAVFLKRNTDVLFNDD
C_elegans_Y45F10B.10                      NVTKRN--------------------------------------------------HDAHDVHADKEGFLTAVALSNDDKYAACGT-NNGIVALWD-LEVCQCVFTT-------------
C_intestinalis_ENSCINP00000010464         STISLL---------SQP----EYSSLKRLS-------------------------------QLGHRTDTKSMCFTMDGMALLTTS--SESAKLWN-RSSHQCIRTL-------------
O_latipes_ENSORLP00000010395              SLKTSD---------ENP----SANKTARLT-------------------------------LGGHRTDVRTLAFSSDNLAVLSAS--GDTVKVWN-RSTLQVIRTM-------------
T_nigroviridis_ENSTNIP00000007980         SLRTAD---------KTP----AGTKTARLT-------------------------------LGGHRTDVRTLAFSSDNLAVLSAS--GDTVKVWN-RATLQVIRTM-------------
T_guttata_ENSTGUP00000006840              ELATSH-----------------------------------------------------CQILYGHTETILALDVFRKGLMFVTCA-KDRSMRVWR------------------------
T_nigroviridis_ENSTNIP00000004057         ELASNS-----------------------------------------------------CQILYGHTDTILSLDVFRKGLLFASCG-KDKLVCVWH------------------------
M_domestica_ENSMODP00000008927            RTSSGT---------EEGQCPVSDAAVSALAWLNPKVLVSGGEDGNLQCWMLAYVTPHRLWLLPAHQKAVLGLATSQE--LLASASAEDFTVRLWS-LQFLTQPNLA-------------
D_rerio_ENSDARP00000023281                TLKTTE---------KNP----TGNKTSRLT-------------------------------LGGHRSDVRTVAFSSDNIAILSAS--GDTVKVWN-RSTLQVIRTM-------------
G_gallus_ENSGALP00000008904               ELSTSH-----------------------------------------------------CQILYGHTETILALDVFRKGLMFVSCA-KDKSIRVWR------------------------
G_aculeatus_ENSGACP00000015863            ELLTNS-----------------------------------------------------CQILYGHTDTVLSLDVFKKGFVFASCA-KDRSVRVWQ------------------------
A_aegypti_AAEL004526-PA                   DTTNMN-----------------------------------------------------CQLVKGHTDIVLSLSANQN--YILSSS-KDNSIRLWR------------------------
M_musculus_ENSMUSP00000060613             SLNASL---------PAP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM-------------
H_sapiens_ENSP00000262715                 KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASAS-EDFTVQLWP-RQLLTRPHKA-------------
T_rubripes_ENSTRUP00000017221             ELLTNS-----------------------------------------------------CQILYGHTDTVLSLDVFRKGSLFASCA-KDRSVCVWQ------------------------
C_intestinalis_ENSCINP00000019387         NMKTSA-----------------------------------------------------CQVLKKHSDTVLCVDVFKNRTHFVSSS-KDNTVCLWR------------------------
G_gallus_ENSGALP00000023833               TLNLSA---------QVP----QAVRASRIT-------------------------------IGGHRSDVRTLAFSSDNIAVLSGA--AESVKIWN-RSTLQCIRTM-------------
P_troglodytes_ENSPTRP00000010340          KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASAS-EDFTVQLWP-RQLLMRPHKA-------------
T_guttata_ENSTGUP00000013749              NLDLSA---------QVT----QAVRVSRIT-------------------------------IGGHRSDVRTLAFSSDNIAILSAA--AESVKIWN-RSTLQCIRTM-------------
T_rubripes_ENSTRUP00000006345             SLKAAS---------TTP----TSNKTARLT-------------------------------LGGHRTDVRTLAFSSDNLAVLSAS--GDTIKVWN-RATLQVIRTM-------------
H_sapiens_ENSP00000308179                 SLNPSL---------PTP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM-------------
R_norvegicus_ENSRNOP00000012235           RISSGP---------QEAQCQELNVAVSALVWLSPSVLVSGAEDGSLHGWMLRRNSLQSLWLSSVCQKPVLGLAASQE--FLASAS-EDFTVRLWP-RQLLTQPHAV-------------
D_melanogaster_FBpp0085899                SFRNEELYVNPYSRHPRRKRSLKRHAQAQRS-------------------------------PSTTLPPITCFDLSRDSQQMAIAS--GRHVHLMR------------------------
P_troglodytes_ENSPTRP00000001997          SLNPSL---------PTP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--ADSVKIWN-RSTLQCIRTM-------------
M_mulatta_ENSMMUP00000011166              SLNPSL---------PTP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM-------------
M_domestica_ENSMODP00000006461            TLNPST---------PAP----QPIRTARIT-------------------------------IGGHRSDVRTLSFSSDNIAILSAA--ADSVKIWN-RSTLQCIRTM-------------
P_pygmaeus_ENSPPYP00000001131             SLNPSL---------PTP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--ADSIKIWN-RSTLQCIRTM-------------
M_mulatta_ENSMMUP00000021364              KISSGS---------QGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQE--LLASAS-EDFTVRLWP-RQLLTLPHKA-------------
B_taurus_ENSBTAP00000026561               SLNAST---------PGP----QPVRTNRIT-------------------------------IGGHRSDVRTLSFSSDNIAILSAA--ADSIKIWN-RSTLQCIRTM-------------
R_norvegicus_ENSRNOP00000026726           SLSTSL---------PNP----QPVRTSRIT-------------------------------IGGHRSDVRTLSFSSDNIAVLSAA--AESVKIWN-RSTLQCIRTM-------------
A_gambiae_AGAP009615-PA                   DVSTMN-----------------------------------------------------CRLVKGHTDIVLSLCANDR--YLLSSS-KDNSIRLWS------------------------
B_taurus_ENSBTAP00000027147               DLQTSA-----------------------------------------------------CQILHGHTDIVLALDVFRKGRLFASCA-KDQSIRVWR------------------------
X_tropicalis_ENSXETP00000035244           SVDLGD---------LVAQTSIEDVTILCVAWLSEEVLVTGTSDSLVRVWKISSGQFTCQLMLKEHQRFVQALAVSSK--LLASAS-GDVSVCLW---SLNSLLNSV-------------
A_aegypti_AAEL004364-PA                   TLNVAE---------KHA----EASAIHTIR-------------------------------QQGHPSEVRSVAFSSDSLAIASGS--GESLKLWS-RASQSSLRTV-------------
O_anatinus_ENSOANP00000004860             SVTPAQ---------PVP----QVVRGAQIS-------------------------------TGGHRTDVRTLSFSSDNIAVLSAS--AESVKIWNSRSTLQCIRTL-------------
E_caballus_ENSECAP00000005446             SLSPSA---------LTT----QPVRASRIA-------------------------------IGGHRSDVRTLSFSSDNIAVLSAS--ADSIKIWN-RSTLQCIRTM-------------
S_cerevisiae_YLR222C                      PVPDLS--------------------------------------------GPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATAS-KDNTAIVWR------------------------
E_caballus_ENSECAP00000009299             KISSGS---------QGAQCQALDVAVSALAWLGPKVLVSGAEDGSLQGWALKESSLQSLWLLSRYQRPMLGLATSQE--LLASAS-EDFTVRLWP-RQLLTLPQKA-------------
X_tropicalis_ENSXETP00000021860           SL-PAE---------PTPAGKAECTRTSRLT-------------------------------LGGHRSDVRTLAFSSDNIAVLSAS--AETVKIWN-RSTLQCIRTM-------------
A_gambiae_AGAP004827-PA                   SFRNEDSIVNFY---PKKKKTLKKFHRNRLA-------------------------------LQSTSSPVICFDVSRDSTMAAVAS--SRCVQIWQ------------------------
M_domestica_ENSMODP00000027702            ELETSD-----------------------------------------------------CQILCGHTDIVLALDVFRKGRLFTSCA-KDQSVRIWR------------------------
X_tropicalis_ENSXETP00000015707           DLETSN-----------------------------------------------------CQILYGHTETVLALDVFKKGLLFASCA-KDRTIRVWR------------------------
M_mulatta_ENSMMUP00000010429              ELQTSA-----------------------------------------------------CQILHGHTDIVLALDVFRKGWLFASCA-KDQSVRIWR------------------------
B_taurus_ENSBTAP00000001564               RISSAS---------QGAQGQALDVAVSALTWLSPKVLVSGAEDGALQGWLLQGGTLQSLWLLSRHRKPVLGLATSQE--LLAIAS-EDFTVRLWP-RQLLMLPQKT-------------
A_aegypti_AAEL001276-PA                   SFRNEDSIVNFF---PKKKKTMKKIAKSRVA-------------------------------LAATSSPVICFDISRDSTTAAVAS--SRCIQIWQ------------------------

                                                 2410      2420      2430      2440      2450      2460      2470      2480      2490      2500      2510      2520
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 EVMVLAVDHIRRL-QLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNN----RIFQSRFQHKKTVWHIQF----TADEKTL-ISSSDDAEIQV-WNW----QLD
P_troglodytes_ENSPTRP00000042795          EVMVLAVDHIRRL-QLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNN----RIFQSRFQHRKTVWHIQF----TADEKTL-ISSSDDSEIQV-WNW----QLD
P_pygmaeus_ENSPPYP00000005543             EVMVLAVDHIKRL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNN----RIFQSRFQHKKTVWHIQF----TADEKTL-ISSSDDSEIQV-WNW----QLD
M_mulatta_ENSMMUP00000038848              EVMVLAVDHIRRL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGTIEILELVNN----RIFQSRIRHKKTVWHIQF----TADEKTL-ISSSDDSAIQV-WNW----QLE
E_caballus_ENSECAP00000022364             EVMILAVDNMRRL-QLINGKTGQIDYLTEAQ---VSSCCLSPHLQYVALGGEDGAIKILELLNN----RIFQSKIGHKSAVRHVQF----TTDGKTL-ISSSDDSVIQV-WNW----QSE
B_taurus_ENSBTAP00000028867               EVTVLAVDNIRRL-QLINGNTGQIDYLTEAQ---VSCCCLSPHLQYLAFGGEDGAIQILELLNN----RIFQSRNGHKTTVRHIQF----TADGKTL-ISSSDDSAVQI-WNW----QSE
C_familiaris_ENSCAFP00000009806           EVMVLAVDNIKRL-QLINGKTGQIDYLIEAQ---VSCCCLSPHLQYIAFGGEDGAVEILELLNN----RIFQSRIGHKKTVRHIQF----TDDGKTL-ISSSDDSSIQV-WNW----QSE
M_musculus_ENSMUSP00000020157             ETMVLAVDNIRGL-QLIAGKTGQIDYLPEAQ---VSCCCLSPHLEYVAFGDEDGAIKIIELPNN----RVFSSGVGHKKAVRHIQF----TADGKTL-ISSSEDSVIQV-WNW----QTG
O_anatinus_ENSOANP00000008896             EVMVLAVDSLRHL-QLINGKTGQTDYLTEAQESLICCCCLSPTLISLAFGEEDGTVKILELPNG----RMFKSKIKHKKPVQHCRF----TSDGKTV-ISSSDDPVIQV-WIW----QTE
M_domestica_ENSMODP00000009538            EVMVLAIDNIRRL-QLINGKTGHTDYLTEAHKSRISCCCLSPGLRFVAFGEEDGSIKILELPNG----REFRSRIGHEKAVRRVQF----TPDGRTL-ISSSDDSTVQV-WNW----QSE
R_norvegicus_ENSRNOP00000010869           EMMVLAVDNIRGL-QLIAGKTGQIDYLPEAQ---VSCCCLSPHLEYVAFGDEEGAIKVLSSTNS----RVQSAKNFHLKAFLHYRF----TRICKER-IESCENCSVFG-VEW----QTE
T_guttata_ENSTGUP00000009081              EVMILAIYNQKNL-QLINGNTDNVIMQTAAQESPISCCCLSEDLKFAAFGQESGTIKVLQLSDG----KVLKSWEAYRTSVQHCRF----TPDCQTL-ISSAHDPVIQV-WNW----QLS
G_gallus_ENSGALP00000037436               EVMILAIYNQKHI-QLINGNTDSIIMQTEPQESLICCCCLSEDLKFAAFGQENGAIKVLRLLDG----RVLTSREAYRTSVQHCRF----TTDCQTL-ISSAHDAVIQV-WNW----QLN
A_carolinensis_ENSACAP00000012965         DVIILAIDSSKRL-QLISGYTGNTIYLTKEQDSLICCCCLSHDRKVAAFGENNGTVKVLSLQNG----NTLNSRTGHREAVQHCQF----TSDGKTL-ISSSDDSTIQV-WNW----QSE
G_gorilla_ENSGGOP00000008216              EVMVLAVDHIRRL-QLINGKTGQIDYLTEAQ---VSCXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXX----XXXXXXX-XXXXXXXXXXV-WNW----QLD
X_tropicalis_ENSXETP00000014654           RTLVLATSKDDCI-LLINGMTGETLSQIRAQDNCVTCCCLSTDYQLAAIGHRDGKVKILDLSGG----EILHKLDGHRDTVQHCQF----TADGKLL-VSSSDDCTVRV-WNL----VSG
O_cuniculus_ENSOCUP00000010200            EVMVLAVDDVRCL-QLINGKTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDEDGTIEILELLNS----RIFQSRIGHKKTVRHIQF----TADGKTL-ISSSDDSAIQ------------
D_rerio_ENSDARP00000008347                DATIIAPDSSNRL-QVLSGSTGAVVLESEELSSRIRCSCISRNAAFVALGSEDGTVQVIEVPSS----KASVKLSGHTKTVHHCQF----TDDCEIL-ITSSEDSTIRV-WKW----RTG
T_rubripes_ENSTRUP00000033561             EIIISAADNCNRL-QVRNGRTGSVLFQSEEKSSRIRCTCLCRQPPAVVIGQEDGTVQVLELPTG----KVLATLLGHTKTVFCCQF----SQDGQTL-ITSSEDTTIRV-WRW----LSG
T_nigroviridis_ENSTNIP00000013938         EIIISAADNCNRL-QVRSGKTGSVLFQSEEKSSRIRSTCLCRNPSAVVIGQENGTVQVLELPTG----KVLATLLGHTKTVFWCQF----SQCGETL-FTSSEDTTIRV-WRW----RSG
G_aculeatus_ENSGACP00000026214            EIIVSAADNCNRLQQVRDGRTGSVLFQSEEKPSRIRCTSMCRQPSAVALGQEDGTVQVLQVPSG----NLLATLLGHTKTVLHCRF----SQSGKTL-LTSSEDTTIRKNWFL----RPF
O_latipes_ENSORLP00000019346              NIFVSAPDHCNRL-QV---RTGDTLLQSEKKPSRIRCTCLLRDLSVVALGQEDGTVQVLAVPSA----KPLATLLGHTKTVLHCQF----THYGQTL-ITSSEDCTIRV-WNL----PSG
C_elegans_Y45F10B.10                      ---------------------------IQNKGDPITCIRYSVDSQYCISGNQAGCILILDAQNG----GVVRELFMHSSEVLSIM-----SLVHNKM-ISCDIQGKMVI-WELFGDDDTP
C_intestinalis_ENSCINP00000010464         ------------------------------KCSHPKCCLFVPGDRQVILGTQEGALELHDVASG----TLLETIQAHEGAVSCVAL----FPNKRGI-VSGGPDKKIKF-WEF----DLI
O_latipes_ENSORLP00000010395              ------------------------------TCEYALCSLFVPGDRQIILGTKSGKLQIFELASG----SLLETSDAHDGAVWSLCL----APDQRGI-VTGGADKTVKF-WEF----ELI
T_nigroviridis_ENSTNIP00000007980         ------------------------------ACEYALCSLFVPGDRQIVLGSESGKLQIFELASA----ALLESVDAHAGAVWALCL----APDQRGL-VTGSADKTVKF-WDF----ELV
T_guttata_ENSTGUP00000006840              ---------------------------MG-QAGRVTC---------------------------------VAHAQSRFPALGGLIP----LRLKESFVVTSSQDCTIKI-WNI----PES
T_nigroviridis_ENSTNIP00000004057         ---------------------------M--AGGSVRC---------------------------------VARGYSHTNAVGAVSC----SRMKASFVVSGSLDCTVKV-WDL----PAD
M_domestica_ENSMODP00000008927            -------------------KKLHPGRELRGHTGPVTCCSFSPDGGILATGSRDQSLLCWDVRMPEAPVVMHSLPACHRDWVTGCSW----TKD--AMLLSCSNDGSVRL-WDP----VSG
D_rerio_ENSDARP00000023281                ------------------------------GCEYALCSIFVPGDRQIILGTKSGKIQIFDLASG----SLLETTDAHEGALWSMCL----SPDQRGI-VTGGADKTVKF-WDF----ELI
G_gallus_ENSGALP00000008904               ---------------------------MN-KDGRVVC---------------------------------VAQGLGHAHGVGAVSC----SRLKESFVVTSSQDCTIKV-WNI----PES
G_aculeatus_ENSGACP00000015863            ---------------------------MDSDSGRVHC---------------------------------VAHGSNHANAVGSITC----SRMKASFVVSGSQDCTLKV-WDL----PAD
A_aegypti_AAEL004526-PA                   ---------------------------YDTAKFTVQC---------------------------------VAIGLKHTNAVGSIAI----SKVSGKFCASVSQDKCLKV-WKI----PKE
M_musculus_ENSMUSP00000060613             ------------------------------PCEYALCSFFVPGDRQVVIGTKTGNLQLYDLASG----TLLETIAAHDGALWSMSL----SPDQRGF-VTGGADKAVKF-WDF----ELV
H_sapiens_ENSP00000262715                 -------------------EDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG
T_rubripes_ENSTRUP00000017221             ---------------------------M--DSGHVRC---------------------------------VARGTSHTNAVGCISC----SRMKASFVASGSLDCTVKV-WDL----PAD
C_intestinalis_ENSCINP00000019387         ---------------------------MEENTYAVTC---------------------------------LVVGAGHTHDVGAVTC----CNNKMEFLVSGSQDQTLKI-WTI----NET
G_gallus_ENSGALP00000023833               ------------------------------DCEYALCSLFVPGDRQVIVGTKTGKLQLYDLASG----TLMETLNAHDGAVWSIAL----SPDQRGF-VTGGADKCVKF-WDF----ELV
P_troglodytes_ENSPTRP00000010340          -------------------EDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG
T_guttata_ENSTGUP00000013749              ------------------------------ECEYALCSLFVPGDRQVIIGTKTGKLQLYDXXXX----XXXETLDAHDGAVWSIAL----SPDQHGF-VTGGADKCVKF-WEF----ELV
T_rubripes_ENSTRUP00000006345             ------------------------------ACEYALCSLFVPGDRQIILGTKSGKLQIFELASG----SLLETVDAHDGALWSLCL----APDQRGL-VTGSADKTVKF-WEF----ELI
H_sapiens_ENSP00000308179                 ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV
R_norvegicus_ENSRNOP00000012235           -------------------EELPCAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKVAQAPLLIHTFSSCHRDWITGCTW----TKD--NILISCSSDGSVGL-WNP----EAG
D_melanogaster_FBpp0085899                ------------------INTPEYQCTLEGHTAGVSCLKFAPNGEFLATGSEDRLVHIWNLALG----EICNSFKGHTAPVVKVVV----LMDSLRV-ISTDRDSMLLV-WMA----HSG
P_troglodytes_ENSPTRP00000001997          ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV
M_mulatta_ENSMMUP00000011166              ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV
M_domestica_ENSMODP00000006461            ------------------------------ACEYALCSLFVPGDRQVIIGTKTGKLQLYDLASG----NLLETVEAHDGALWSISL----SPDQHGF-VTGGADQSVKF-WDF----ELV
P_pygmaeus_ENSPPYP00000001131             ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSMSL----SPDQRGF-VTGGADKSVKF-WDF----ELV
M_mulatta_ENSMMUP00000021364              -------------------EDFPGGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKAPILIHSFPACHRDWVTGCAW----TKD--NLLISCSSDGSVGL-WDP----ESG
B_taurus_ENSBTAP00000026561               ------------------------------ACEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSLSL----SPDQRGF-VTGGADKSVKF-WDF----ELV
R_norvegicus_ENSRNOP00000026726           ------------------------------PCEYALCSFFVPGDRQVVIGTKTGNMQLYDLASG----NLLETIAAHDGALWSMSL----SPDQRGF-VTGGADKAVKF-WDF----ELV
A_gambiae_AGAP009615-PA                   ---------------------------FTEEPFTISC---------------------------------VAIGLKHTNTVGCVTL----SRQGGNFCASVSQDRCLKT-WKI----PKK
B_taurus_ENSBTAP00000027147               ---------------------------MN-KSGEVAC---------------------------------VAQGSGHTHSVGTICC----SRLKETFLVTGSQDCTVKL-WPL----PEA
X_tropicalis_ENSXETP00000035244           -------------------SPPSPASVLQGHSAAVTCCSFSRNGKLLATGSQDRSVLCWDVSLI-PPSVVHALPSCHRDWVTACSW----TDA--DMLVSCSGDGSVCL-WDI----QRE
A_aegypti_AAEL004364-PA                   ------------------------------DTGYVVSTCFVPGDRHVLVGLKTGQLLIVDIVTG----EIIERIAAHEKELWSIVL----TPDMRGC-VTGGGDTTVKF-WSF----ELI
O_anatinus_ENSOANP00000004860             ------------------------------ACEYALCSLFVPGDRQVIVGTKKGKLQLYDLASA----SLLETVEAHAGAVWSISL----SPDQRGF-VTGGADKTVRF-WDF----HLV
E_caballus_ENSECAP00000005446             ------------------------------TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASG----NLLETIDAHDGALWSLSL----SPDQRGF-VTGGADKSVRF-WDF----ELV
S_cerevisiae_YLR222C                      ---------------------------YNENSCKFDI---------------------------------YAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKK-WII----PKP
E_caballus_ENSECAP00000009299             -------------------EDFPCATELRGHEGPVSCCSFSTDGGSLATGGRDRNLLCWDVRTPKAPVLICSFSACHRDWVTGCAW----TKD--NLLVSCSSDGSVGL-WDP----ESG
X_tropicalis_ENSXETP00000021860           ------------------------------PCEYALCSLFVPGDRHVIIGTKSGNLQLFDLASG----NLLETVNAHDGAVWSICP----SPDLRGF-ASGGADKTVRF-WDF----ELV
A_gambiae_AGAP004827-PA                   ------------------LNSPELTSILEGHSATVTCVSFAPNCELVASGSEDKTVNVWSLGLG----TVTATFKGHCTSISSVTF----MMDARRI-ISADRDGLLYV-WIS----DSG
M_domestica_ENSMODP00000027702            ---------------------------MN-ATGKVHC---------------------------------IAHGSGHTHSIGTISC----SRLKETFLVTGSQDCTIKL-WPL----PEP
X_tropicalis_ENSXETP00000015707           ---------------------------MKKATGKVTC---------------------------------VAQGSGHTNGVGTISC----SRMKEAFLVSGSQDYTIKL-WKL----PES
M_mulatta_ENSMMUP00000010429              ---------------------------MN-KAGQVIC---------------------------------VAQGSGHTHSVGTVCC----SRLKESFLVTGSQDCTVKL-WPL----PKA
B_taurus_ENSBTAP00000001564               -------------------EDFPRSTELRGHEGPVSCCSFSTDGCRLATGGRDRSLLCWDVRTPKAPVLICSFSACHRDWVTGCAW----TKD--SLLVSCSSDGSVAL-WDP----ESR
A_aegypti_AAEL001276-PA                   ------------------LNTPELTAILEGHTGTVTCVSFAPNCEFVASGSEDKTVNVWSLALG----TIVTTFKGHNTFVTSVTF----LMDSRRI-ISADRESCLFV-WMA----DSG

                                                 2530      2540      2550      2560      2570      2580      2590      2600      2610      2620      2630      2640
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQG-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN
P_troglodytes_ENSPTRP00000042795          KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQG-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN
P_pygmaeus_ENSPPYP00000005543             KYIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNTEKDFVCHQG-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---HLLPLH-ELRGHN
M_mulatta_ENSMMUP00000038848              EYVFLQAHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GKIEKDFVCHQG-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN
E_caballus_ENSECAP00000022364             EYVFLQAHQEAVKDFRLLRNS----RLLSWSFD---GTV-KVWNIIT--GRIEKDFVCHQD-TVLSCDIS----PDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK
B_taurus_ENSBTAP00000028867               DPFFLQAHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--RRIEKDFVCHQD-TVLSCDIS----SDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK
C_familiaris_ENSCAFP00000009806           EYVFLQAHQETVKDFKLLKNS----KLLSWSFD---GTVKKIWSIIT--GRIEKDFVCHQD-TVLSCDIS----PDAT-----KFSSTSADK----TAKIWSFE---LLSPLH-ELRGHK
M_musculus_ENSMUSP00000020157             DYVFLQAHQETVKDFRLLQDS----RLLSWSFD---GTV-KVWNVIT--GRIERDFTCHQG-TVLSCAIS----SDAT-----KFSSTSADK----TAKIWSFD---LLSPLH-ELKGHN
O_anatinus_ENSOANP00000008896             EYVFLQAHQESVKDFRLLQNS----RLFSWSFD---GTI-KVWNILT--GKVEKDFFCHQG-AVLSCNIS----PDAT-----KFSSTSADK----TAKIWSFE---NSSLLH-ELSGHE
M_domestica_ENSMODP00000009538            EFVFLKAHQEPVKDFRLLQNS----RLLTWSFD---GTV-KVWNILT--GKVEKDFTCHQG-TVLSCDVS----PNAT-----KFSSTSADK----TAKIWNFE---SSFPLH-ELRGHE
R_norvegicus_ENSRNOP00000010869           EYVFLQAHQETVKDFRLLRDS----RCFPGSFD---GTV-KVWNVIT--GRIERDFTCHQG-TVLSCAIS----SDAT-----KFSSTSADK----TAKIWSFE---LPSPLH-ELKGHN
T_guttata_ENSTGUP00000009081              ECVFLRGHNEAIKDFRLLENS----KILSWSFD---GTV-KVWNITT--GNPERDFACHRD-AVLSCAVS----PDGS-----KFSSASADK----TAKIWSFE---SSSVLH-ELKDHE
G_gallus_ENSGALP00000037436               ECVFLKGHKEAIKDFAFLENS----KLLSWSFD---GTV-KVWNITT--GKTEKDFACHRG-AVLSCAVS----PDGS-----RFSSTSADK----TAKIWSFE---SSSVLH-ELKGHE
A_carolinensis_ENSACAP00000012965         ECILLKGHNERVKKFLLLKDS----RLLSWSFD---GTV-KLWNIVT--GEIEKDVICHEN-AILSCAIS----PDAT-----MFSTTSSDK----TAKIWSFE---TSSMLH-KLNSHE
G_gorilla_ENSGGOP00000008216              KCIFLRGHQETVKDFRLLKNS----RLLSWSFD---GTV-KVWNIIT--GNKEKDFVCHQG-TVLSCDIS----HDAT-----KFSSTSADK----TAKIWSFD---LLLPLH-ELRGHN
X_tropicalis_ENSXETP00000014654           KNLELCGHKEPVKFFKILQES----KVFSWSFD---GTV-KVWNLLT--GQLIKEFICHSA-TVLACDIS----PDST-----KFSSASTDK----SAKIWNLD---NCALLH-ELNKHQ
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ECMVLQGHMEPVRKFHLLSSS-SSPRLFSWSFD---GTV-KVWDLTR--GQMLQDLVCHEG-AVLSCDVS----SDGR-----LFATTSANR----TAKVWSSA---SWKMIF-LLEGHK
T_rubripes_ENSTRUP00000033561             ECKVLQGHREQVRCFTLLSSSPSKMRLLSWSFD---GTV-KMWDTES--GEKLQDVEAHQG-AILSCHVS----PDGC-----LFATTSADR----TAKLWHCE---SWQCVH-ALKGHQ
T_nigroviridis_ENSTNIP00000013938         ECKTLLGHREQVRHFSLLSSSPSDTRLLSWSFD---GTV-KMWDTES--GEKLQDMEAHQG-AILSCHVS----PDGC-----FFATTSADR----TAKLWHCE---SWQCVH-TLKGHQ
G_aculeatus_ENSGACP00000026214            QKGKAVLSFSPFLSFEINNPTTGG------------GAF-CWLGGGV--SSRMRAWGFHEG-RLRQIRVG----GGGGGGKERMERNRKTNE----GPKLWHCE---TWKCVH-TLSGHR
O_latipes_ENSORLP00000019346              ECKVLQGHKEQVRCFALLSPSSNDSRLLSWSFD---GTV-KVWNTES--GQKLQDIDAHGG-AILSCHVS----PDGR-----LFATSSADR----TAKLWHCE---AWQCTF-TLTGHQ
C_elegans_Y45F10B.10                      EMVATGVKPPIFVPPTGRIM-----VGHCSLSNKEM----KIWAFPEEGPPVTRAKLSHSD-EITCFATS----PKGGN----FIATGSRDM----SLKIWQID---KGFLTQ-VLVGHE
C_intestinalis_ENSCINP00000010464         SDENYSVS-S------------------------------KRVSL------THTRTFELDD-QILDVEFT----PNNR-----FIAASLLDC----SVKIFYVD---SLKFFL-SLYGHS
O_latipes_ENSORLP00000010395              KDQSSA-Q--------------------------------KRLAV------KHVRTLQLED-DVLCVRFS----PDHR-----LLAASLLDC----TVKIFHSD---TLKFFL-SLYGHK
T_nigroviridis_ENSTNIP00000007980         KDQDAG-H--------------------------------KRLTV------KHTRTLQLEE-DVLCVKLS----PDHR-----LLAVSLLDC----TVKLFYAD---TLKFFL-SLYGHK
T_guttata_ENSTGUP00000006840              LTSKAKAALI-S----------------------------SPEPL-----HARVTERGHDK-DINSVAVS----PNDK-----LLATGSQDR----LAKLWSCS---DCSLLG-VFSGHK
T_nigroviridis_ENSTNIP00000004057         LTAAE------D----------------------------NIHQL-----TPRATEKAHDK-DVNSVTVS----PNDK-----LLASASQDR----TAKLWSLAGEGSLGLLG-VCRGHR
M_domestica_ENSMODP00000008927            QQLGQFLGHQSAVSTVVAVEE----HVVSVDRDGVL----KVWNL-R--GVELTSIPAHSG-PISHCVAIQEPRTAGQPGSELLVITVGLDG----ATRLWHPL---LVFQTH-TLLGHS
D_rerio_ENSDARP00000023281                KDEDSMIN--------------------------------KRLTV------KHTRTLQLDE-DVLCVRFS----PDQR-----LLAVSLLDC----TVKIFYTD---TLKFFL-SLYGHK
G_gallus_ENSGALP00000008904               LTSKAKAALI-S----------------------------GPETL-----HAQMTERGHDK-DINSVAVS----PNDK-----LIATGSQDR----LAKLWSCP---DCSLLG-VFTGHK
G_aculeatus_ENSGACP00000015863            LSTTG------G----------------------------DLHHL-----TPRATEKAHDK-DVNSVAVS----PNDK-----LLASGSQDR----TAKLWSLEAAGRVGMLG-VFRGHR
A_aegypti_AAEL004526-PA                   FNETTDEK--------------------------------ELTRL-----NCTLTELAHEK-DINCVCIS----PNDR-----LIATGSQDK----TAKLWDAS---NLSLVG-VFRGHR
M_musculus_ENSMUSP00000060613             TDKNST-Q--------------------------------KRLSV------KQTRTLQLDE-DVLCVSYS----PNQK-----LLAVSLLDC----TVKVFYVD---TLKFFL-SLYGHK
H_sapiens_ENSP00000262715                 QRLGQFLGHQSAVSAVAAVEE----HVVSVSRDGTL----KVWDH-Q--GVELTSIPAHSG-PISHCAAAMEPRAAGQPGSELLVVTVGLDG----ATRLWHPL---LVCQTH-TLLGHS
T_rubripes_ENSTRUP00000017221             LTAAE------E----------------------------SIQQL-----TLRTTEKAHDK-DVNSVAVS----PNDK-----LLASASQDR----TAKLWSLAGEGNLGLLG-VFRGHR
C_intestinalis_ENSCINP00000019387         F------------------------------------------QL-----RVKHTVMAHSK-NINSIVVS----PNDK-----LIASGSQDK----LAKLWKVS---DGSVVG-TFKGHK
G_gallus_ENSGALP00000023833               KDESSI-Q--------------------------------KRLSM------KQVRILQLDE-DVLCVRYS----PNQK-----LLAVSLLDC----TVKVFYTD---TLKFFL-SLYGHK
P_troglodytes_ENSPTRP00000010340          QRLGQFLGHQSAVSAVAAVEE----HVVSVSRDGTL----KVWDH-Q--GVELTSIPAHSG-PISHCAAAMEPRAAGQPGSELLVVTIGLDG----ATRLWHPL---LVCQTH-TLLGHS
T_guttata_ENSTGUP00000013749              KDESSV-Q--------------------------------KRLSM------KHVRVLQLDE-DVLCVRYS----PNQK-----LLAVSLLDC----TVKVFYVD---TLKFFL-SLYGHK
T_rubripes_ENSTRUP00000006345             KDGEMS-H--------------------------------KRLTV------KHKRTLQLEE-DVLCVKFS----PDHR-----LLAVSLLDC----TVKLFYTD---TLKFFL-SLYGHK
H_sapiens_ENSP00000308179                 KDENST-Q--------------------------------KRLSV------KQTRTLQLDE-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
R_norvegicus_ENSRNOP00000012235           QQLGQFPGHQSAVSAVVAVEE----HIVSVSRDGTL----KVWDR-Q--GVELTSIPAHSG-PISQCAAALEPRPAGQPGSELLVVTVGLDG----ATKLWHPL---LVCQIH-TLQGHS
D_melanogaster_FBpp0085899                NLLQTIQGPYKSLSVTNNMR-----FAVSTNGDNTL----KIWSLTQ---EDEKYSVSHSD-EITCFEIS----ADSV-----HIISGSRDM----SLKVWQAT---GGKLSQ-VLVGHS
P_troglodytes_ENSPTRP00000001997          KDENST-Q--------------------------------KRLSV------KQTRTLQLDE-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
M_mulatta_ENSMMUP00000011166              KDENST-Q--------------------------------KRLSV------KQTRTLQLDE-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
M_domestica_ENSMODP00000006461            KDENCA-Q--------------------------------KRLSV------KQTRILQLDE-EVLSVRYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
P_pygmaeus_ENSPPYP00000001131             KDENST-Q--------------------------------KRLSV------KQTRTLQLD--DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
M_mulatta_ENSMMUP00000021364              QRLGQFLGHQSAVSAVAAVEE----HVVSVGRDGTL----KVWDH-Q--GVELTSIPAHSG-PISHCAAAMEPRAAGQPGSELLVVTIGLDG----ATRLWHPL---LVSQTH-TFLGHS
B_taurus_ENSBTAP00000026561               KDENST-Q--------------------------------KRLSV------KQTRTLQLDE-EVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
R_norvegicus_ENSRNOP00000026726           TDKNST-Q--------------------------------KRLSV------KQTRILQLDE-DVLYVCYS----PDQR-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
A_gambiae_AGAP009615-PA                   FT-TEEDG--------------------------------ELPRL-----QCSLTALAHEK-DINCVTIS----PNDR-----LIATASQDK----TAKLWDAS---DLSVVG-VFRGHT
B_taurus_ENSBTAP00000027147               LLSKGTGHE--G----------------------------GPVFL-----QAQATQRCHDK-DINSVAVA----PNDK-----LLATGSQDR----TAKLWALP---RCQLLG-TFSGHR
X_tropicalis_ENSXETP00000035244           ERLLDFAGHQSAVSSAICMGE----RVITTSRDGCL----KVWNL-A--GLEVANISAHQE-QINQSAAFWMP-VDRQDDANLVVYVACSDG----SVLKWSPL---QMDQIQ-TLYGHG
A_aegypti_AAEL004364-PA                   ADPTKDAKSEV-----------------------------KVLSL------LHKNVLKLEE-TVLCVRIS----RNSK-----YIAVALLDS----TVKIFFLD---TLKFYL-SLYGHK
O_anatinus_ENSOANP00000004860             KDADGP-Q--------------------------------KRLSV------GEARTLQLDE-EVLCVRYG----PDRK-----LLAVSLLDC----TVKLFYVD---TLKFFL-SLYGHK
E_caballus_ENSECAP00000005446             KDENST-Q--------------------------------KRLSV------KQTRTLQLDE-DVLCVSYS----PNQK-----LLAVSLLDC----TVKIFYVD---TLKFFL-SLYGHK
S_cerevisiae_YLR222C                      TASMDV----------------------------------QIIKV------SEYTRHAHEK-DINALSVS----PNDS-----IFATASYDK----TCKIWNLE---NGELEA-TLANHK
E_caballus_ENSECAP00000009299             QQLGQFLGHQSAVSAVVAVEE----HVVSVGRDGTL----KVWDH-Q--GVELTSIPAHSG-PISQCAAALEPRAAGQPGSELLVVTAGLDG----TTQLWHPL---LVFQTH-TLLGHS
X_tropicalis_ENSXETP00000021860           NEETEE-QSS------------------------------RRLSV------KQTRVLQLDE-DVLCVRYS----PNGR-----ILAVSLLDC----TVKVFYTD---TLKFFL-SLYGHK
A_gambiae_AGAP004827-PA                   MILQSVQGPHKCLSVTNNMK-----FAVCTNGDSSL----RIWSLTR---EDEKYTVSHSD-EITCFIIT----ADSL-----YVITGSRDM----SLKVWQAT---GGKLAQ-VLVGHT
M_domestica_ENSMODP00000027702            ITSKKMTKNPNC----------------------------DPFPL-----QAQATQRAHDK-DINSVAVS----PNDK-----LLASGSQDR----TAKLWSLP---DFSLLG-VFSGHR
X_tropicalis_ENSXETP00000015707           LANKQSKGNS-G----------------------------DLETL-----LACATEKAHDKRDTIKLWQH----RDSP-----VLSTIQQEQPPKDTIKLWQHR---DSPVLSTILQEQP
M_mulatta_ENSMMUP00000010429              LLSKNTAPD--N----------------------------GPILL-----QAQTTQRCHDK-DINSVAIA----PNDK-----LLATGSQDR----TAKLWALP---QCQLLG-VFSGHR
B_taurus_ENSBTAP00000001564               QQLGHFLGHQHAVSAVVAVEE----HVVSVGRDGTL----KVWDH-Q--GVEMTSIPAHSG-PISHCVAALEPRAAGQPGSELLVVTVGLDG----ATRLWHPL---LVFQTH-TLLGHS
A_aegypti_AAEL001276-PA                   TILQSVQGPFKCLAVTNNMK-----FAVCTNGDTSL----RIWSLTR---EDEKFLVSHSG-EITCFIIT----ADSL-----YLISGSKDM----SLKVWQAS---GGKLAQ-VLVGHT

                                                 2650      2660      2670      2680      2690      2700      2710      2720      2730      2740      2750      2760
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCFSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
P_troglodytes_ENSPTRP00000042795          GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCFSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
P_pygmaeus_ENSPPYP00000005543             GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCFSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
M_mulatta_ENSMMUP00000038848              GCVRCSAFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPLS-EEGAATHGGWVTDLCFSPDGKMLISAG--GYIK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
E_caballus_ENSECAP00000022364             GCVRCSVFSGD-STLLATGDDN-GEIRIWSVSNGELLHLCAPISVEEGAATHGGWVTDLCFSPDSKMLVSAE--GSLK--WWNAVTGESAQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
B_taurus_ENSBTAP00000028867               GCVRCSSFSVN-NTLLATGDDN-GEIRIWNVSNGELLHLCAPISVEEGAATHGGWVTDLCFSPDTKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
C_familiaris_ENSCAFP00000009806           GCVRCSVFSVD-STLLATGDDN-GEIRIWNVSNGELLHLCAPILVEEGAATHGGWVTDLCFSPDSKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTCLKKIHVSSDFKTYVTVDNLGI
M_musculus_ENSMUSP00000020157             GCVRCSAFSLD-GILLATGDDN-GEIRIWNVSDGQLLHSCAPISVEEGTATHGGWVTDVCFSPDSKTLVSAG--GYLK--WWNVATGDSSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGI
O_anatinus_ENSOANP00000008896             GCVRCSAFSDD-SSLLATGDDN-GEIRIWDVSKGEILHLCAPGPVGE-ASTHGGWVTDLCFSPDSKILVSAG--GFLK--WWNMDTGESLQTFYTNGTNLKTIFVSPSFKSYVTVDNLGI
M_domestica_ENSMODP00000009538            GCVRCSVFSGD-NALLATGDDN-GEIRIWSVSSGGLLHSCLPLTVEEGEATYGGWVTDLHFSPDGRMLVSAG--GYLK--WWDVDTGESLQTFYTNGTNLKTIHVSPSFRAYVTVDNLGI
R_norvegicus_ENSRNOP00000010869           SCVRCSAFSLD-GILLATGDDN-GEIRIWNVSDGQLLHLCAPISIEEGTATHGGWVTDVCFSPDRKMLVSAG--GYLK--WWNVVTGESSQTFYTNGTNLKKIHVSPDFRTYVTVDNLGI
T_guttata_ENSTGUP00000009081              ACVRCCTFSPN-NKLLATGDDK-GEIRIWDVLTGTLLHFCSPVTVDEGEPTHGGWVTDLSFSPDSKMLVSSG--GYLK--WWNVTTGESLQTFYTNGTNLKSIHVSPNFKVYVTVDNLGI
G_gallus_ENSGALP00000037436               ACVRCSAFSPS-NKLLATGDDK-GDIRIWDILTGELLHFCSSVTVDEEEPTHGGWVTDLSFSPDSKMLVSSG--GYLK--WWDVTTGESLQTFYTNGTNLKSIHVSPNFDVYVTVDNLGI
A_carolinensis_ENSACAP00000012965         SCVRCCAFSLN-NELLATGDDN-REIRVWDVSRGELLHLCSRASIDEGESAHEGWVTDLCFSPDNKILVSSA--GYIK--WWNVDTGQPLQTFYTNGTDLKSLHVSPDFKVCVTVDNLGI
G_gorilla_ENSGGOP00000008216              GCVRCSAFSVD-STLLATGDDN-GEIRIWNXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXX--WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGI
X_tropicalis_ENSXETP00000014654           SCVRCCRFSWD-NQYLATGDDS-GKIMIWSVQNGELLRECCDVSVNNENSLHDGWVTDLHFSPDNKLIVSSG--ANIK--WWEVDTGACKQTFYTIGTNLKSIHVCSIFRTFVTIDNLGI
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                DCVRSCRFSWD-NKRLATGDDN-GEIRLWSMLDGALLKICSRDTKDSMDSYHGGWVTDLHFSPDNRVLVSTG--GYIK--WWSVESGEALQTFYTMGGNLKKIHVSPDFSTFITVDSIGI
T_rubripes_ENSTRUP00000033561             ECVRSCRFSWD-SRRVATGDDN-GEIRLWSVSDGSLLKICSRDSKDGMDSLHGGWVTDLHFSRDDSLLVSTG--GYIK--WWDVAQGEALQTFHPTGSALKRIHVSADFSTFVTIDNIGI
T_nigroviridis_ENSTNIP00000013938         ECVRSCRFSWD-SRRVATGDDN-GEIRLWSAKDGSLLKICSREGKDGMDSLHGGWVTDLHFSRDNTLLVSTG--GYIKKYWGSIPSLQSAHFF---------------------------
G_aculeatus_ENSGACP00000026214            DCVRSCRFSWD-GRRLATGDDN-GEIRLWSVMEGTLLRICSRDGKDCMDSLHGGWVTDLHFSPDNGLLVSTG--GYIK--WWDVETGEALQTFFTTGTALKRIHVSSDFSTFVTIDSIGI
O_latipes_ENSORLP00000019346              ECVRSCRFSWD-SECLATGDDN-GEIRLWNVNDGSLLRICSREVKDSMDSFHGGWVTDLHFSPDNSLLVSAG--GYIK------------------------------------------
C_elegans_Y45F10B.10                      NVVTCCCISFD-ERLVVSGARD-EKIIVWNVQSGDMVCTV----------NTTAAITSLSMTGDSTVVFSTTEDGWVE--TWSTTKGRLLSTFNAHRPIKKLINSYESHRMLLLLENCAQ
C_intestinalis_ENSCINP00000010464         LPPSCVSISSD-STLIVSGSPD-RNVKIWGLDFGDCHRSL---------FAHDNDVTGLKFVPDTHLFFSCGKDGLVK--QWDADNFTLIQVLQGHLGPVWSLCVSPDGDHVATCGNDRS
O_latipes_ENSORLP00000010395              LPVLCLDISHD-STLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMFLQFVPKTHLFFTAGKDRKIK--QWDADKFELVQTLEGHHREVWCLAISPNGDHLVSASHDKS
T_nigroviridis_ENSTNIP00000007980         LPVLCLDICHD-STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQFVPKTHLFFTAGKDKKIK--QWDADKFEHVQTLEGHHREVWCLAISPNGDHLVTASHDKS
T_guttata_ENSTGUP00000006840              RGIWCVQFSPV-DQVLATSSAD-GTLKLWGLRDFSCLKTF---------EGHDASVLKIIFVSRGAQLLSSGSDGLLK--LWTIKTNECVKTLDGHEDKIWGLHSNKKDDMVVTASSDSC
T_nigroviridis_ENSTNIP00000004057         RGVWAVCFSPV-DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVIFVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGSRRDDKMVTGSADSN
M_domestica_ENSMODP00000008927            GPIISAAASET-LGLLLTASKD-GSVRLWHVPKE-DDTGA---------GERPTAITAVAWAPDGSLAVSGSQAGELI--LWQDAK--AVARAQVPGR-VSALCWISPQTFFALISDKNL
D_rerio_ENSDARP00000023281                LPVLCLDISHD-SALIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQFVPKTHLFFTAGKDKKIK--QWDADKFEHIQTLEGHHREVWCLAISPNGDHIVSSSHDKS
G_gallus_ENSGALP00000008904               RGIWCVQFSPV-DQILATSSAD-GTLKLWGLQDFSCLKTF---------EGHDASVLKIIFVSRGTQLLSGGSDGLLK--LWTIKTNECVKTLDGHEDKIWGLHTNKQDDMVVTASSDSS
G_aculeatus_ENSGACP00000015863            RGVWAVCFSPI-DQVLATSSAD-GAAKLWGLQDFSCLKTF---------EGHDASVLKVIFVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGSRKDDKMVTGSADSN
A_aegypti_AAEL004526-PA                   RGIWAVRFSPV-DQILLTNAAD-CSIKLWSLTDMTCLKSL---------EGHESSVLRVEFLSHGMQLLSAGADGLLK--LWSIKTSECLQTLDKHESRIWALCVTEDESVFYSGGSDSQ
M_musculus_ENSMUSP00000060613             LPVLCMDISHD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLRFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKS
H_sapiens_ENSP00000262715                 GPVRAAAVSET-SGLMLTASED-GSVRLWQVPKEADDTCI---------PRSSAAVTAVAWAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSAHTFFVLSADEKI
T_rubripes_ENSTRUP00000017221             RGVWTVCFSPV-DQVLATSSAD-GTTKLWSLQDFSCLKTF---------EGHDASVLKVIFVSRGTQLLTSGSDGLVK--LWTIKTNECVKTLDAHQDKVWGLHGNRRDNRMVTGSADSN
C_intestinalis_ENSCINP00000019387         RGIWCVQFSPM-DQVLATSSAD-GSIKLWSLSDFTCLKTL---------EGHDCSVLKVIFIAKGTQMVSCGSDGLLK--LWTIKLSECIQTVEAHDEKAWALCSDVEDTMIISGGADSI
G_gallus_ENSGALP00000023833               LPVLCMDISYD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLQFVAKSHLFFTAGKDNKIK--QWDADKFEHIQTLEGHHQEVWCLALSPNGDYVVSASHDKS
P_troglodytes_ENSPTRP00000010340          GPVRAAAVSET-SGLMLTASED-GSVRLWQVPKEADDTCI---------PRSSAAVTAVAWAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSAHTFFVLSADEKI
T_guttata_ENSTGUP00000013749              LPVLCMDICYD-GTLIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMYLQFVPKSHLFFTAGKDSKIK--QWDADKFEHIQTLEGHHQEVWCLALSPNGDYVVSASHDKS
T_rubripes_ENSTRUP00000006345             LPVLCLDICHD-STLIATGSAD-RNVKIWGLDFGDCHRSM---------FAHDDSVMFLQFLPKTHLFFTAGKDKKIK--QWDADKFEHIQTLEGHHREVWCLAVSPSGDHLVSASHDKS
H_sapiens_ENSP00000308179                 LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS
R_norvegicus_ENSRNOP00000012235           GPVTAAAASEA-SGLLLT-SDN-SSVRLWQIPKEADDTCK---------PRSSAVITAVAWAPDGSLVVSGNEAGELT--LWQKAQ--AVATARAPGR-VSDLIWCSANAFFVLSANENV
D_melanogaster_FBpp0085899                DAVTCVAVSVTNKTQVLSGSKD-MNLILWDLLTGEEVHTL---------AGHLGPVIGVKVSADGSTAVSGSDDKTLI--VWETKRGLALTSLQMHVPFTHFDISLEVSRVLVQLVDSYN
P_troglodytes_ENSPTRP00000001997          LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMDLQFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS
M_mulatta_ENSMMUP00000011166              LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS
M_domestica_ENSMODP00000006461            LPVLCMDISSD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHEDSVMYLQFVPKSHLFFTAGKDHKIK--QWDADRFEHIQTLEGHHQEVWCLAVSPNGDYIVSSSHDKS
P_pygmaeus_ENSPPYP00000001131             LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEVWCLAVSPSGDYVVSSSHDKS
M_mulatta_ENSMMUP00000021364              GPVRAAAVSET-SGLLLTASED-GSVRLWQVPKEADDTCI---------PRSSAAITAMAWAPDGSMAVSGNQAGELI--LWQEAK--AVATAQAPGH-IGALIWSSARTFFVLSADEKI
B_taurus_ENSBTAP00000026561               LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLRFVPKSHLFFTAGKDRKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS
R_norvegicus_ENSRNOP00000026726           LPVICMDISHD-GALIATGSAD-RNVKIWGLDFGDCHRSL---------FAHDDSVMHLRFVPKSHLFFTAGKDHKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKS
A_gambiae_AGAP009615-PA                   RGIWAVRFSPV-DQILLTNAAD-CTIKLWSLEDMTCLKTL---------EGHDSSVLRVEFLTNGMQLLSAGADGLVK--LWSIKTSDCVQTLDKHDNRVWALCVTRDESMFYSGGSDSQ
B_taurus_ENSBTAP00000027147               RGLWCVQFSPM-DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAFVSRGTQLLSSGSDGLLK--LWTIKNNECVRTLDAHEDKVWGLHCSRLDDRALTGASDSR
X_tropicalis_ENSXETP00000035244           GPVISSSSSSSNCKVIATASLD-GSVRLWEEPSRDGHVME---------TRHVGRVSAIAYSPDSELVASGGENGDVI--LWSQQR--VLLSLQVNKMCISHLLFTSQRTFCVISNDLKV
A_aegypti_AAEL004364-PA                   LPVLCMDISYD-STIIVTGSAD-RSIKIWGMDFGDCHRSL---------IAHDNSVMGLQFIPKTHLFFSCGKDGKLK--QWDADSFEKIITFQGHVGEAHSLAVSPNGKFVVTCGSDRT
O_anatinus_ENSOANP00000004860             LPVLCMDISSD-GQLLATGSAD-RNVKIWGLDFGDCHRSL---------FAHADSVMFLQFVPKTHLFFTAGKDNKIK--QWDADKFEHVQTLEGHHHEVWCLAVSPSGDHLVSASHDKS
E_caballus_ENSECAP00000005446             LPVICMDISYD-GALIATGSAD-RNVKIWGLDFGDCHKSL---------FAHDDSVMYLQFVPKSHLFFTAGKDRKIK--QWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS
S_cerevisiae_YLR222C                      RGLWDVSFCQY-DKLLATSSGD-KTVKIWSLDTFSVMKTL---------EGHTNAVQRCSFINKQKQLISCGADGLIK--IWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGV
E_caballus_ENSECAP00000009299             GPVSAAAVSET-SGLLLTTSED-GSVRLWQVPKEADDTYI---------PRSPTAITAVAWAPDGSLAVSGNQAGELT--LWQEAK--AVATAQAPGR-ISSLVWYSAHTLIVLSADEKV
X_tropicalis_ENSXETP00000021860           LPVLCMDICHD-NGLFVPGFAD-RNVKIWGLDLGDCHRSL---------FAHEDSVMFLQFVPKTHLFFSAGKDRKVK--QWDADHFQQVQTLEGHHGEVWCLAVSPNGDHVVSSSHDKS
A_gambiae_AGAP004827-PA                   DAVTCVAVSVTNKSQVISGSKD-SNLIIWDIHTGEEIHTL---------AGHLGPVTCVKVSADGTTAVSGSDDKTLI--VWETKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDNSC
M_domestica_ENSMODP00000027702            RGVWCVQFSPM-DQVLATASAD-GSLKLWGLQDFSCLKTF---------EGHDASVLRVTFVSRGTQLLSSGSDGLLK--LWTIKTNECVRTLDGHEDKVWGLHCNRQDEAVVTGASDAR
X_tropicalis_ENSXETP00000015707           PKFAHSLYREI-PQNYSSIEIPLDTIKIWHHRDSPVLSTI---------QQEQPPNFAPVPSLLLYPSPLSGSDGLLK--LWTIKTNECVKTLDTHEDKVWGLHCNREDDALVTGSADSA
M_mulatta_ENSMMUP00000010429              RGLWCVQFSPM-DQVLATASAD-GTIKLWALQDFSCLKTF---------EGHDASVLKVAFVSRGTQLLSSGSDGLVK--LWTIKNNECVRTLDAHEDKVWGLHCSRLDDRALTGASDSR
B_taurus_ENSBTAP00000001564               GPVSAAAVSET-SGLLLTTSED-GSLRLWQVPKEADDTYR---------PRSPAAITAVAWAPDGSAAVSGNQAGELT--LWQEAK--AVVTVQAPGC-ISALLWYSAHTLIVVSANEKV
A_aegypti_AAEL001276-PA                   DAVTCVAVSVTNKSQVISGSKD-SNLIIWDIHTGEEIHTL---------AGHLGPVTCVKVSADGTTAVSGSDDKTLI--VWEIKRGLALTSLQLHVQFTRFDISLECSRIVVQLVDSSC

                                                 2770      2780      2790      2800      2810      2820      2830      2840      2850      2860      2870      2880
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 LYI--------------------LQTLE--------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          LYI--------------------LQTLE--------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             LYI--------------------LQTLE--------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              LYI--------------------LQTLE--------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             LYI--------------------LQVLE--------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               LYI--------------------LKILE--------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           LYI--------------------LQMLE--------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             LYI--------------------LQVLE--------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             LYV--------------------LQMLE--------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            LYI--------------------LQALE--------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           LYI--------------------LQVLE--------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              LYV--------------------LQ-----------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               LYV--------------------LRKL---------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         LYV--------------------LRIME--------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              LYI--------------------LQTLE--------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           LYV--------------------LQLIE--------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                LYI--------------------LKRLEGEGT----------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             LYV--------------------LQRVIASGC----------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            LYV--------------------LQRVVIDRGYGA-------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      LPILCLHNTPAVGVEATRRRSARAQSVSSASNEPVASTSAGEIKKDPILS-----------------SNNGGNAQSAPRATAPKPTFDMLERSKSRTSLIEKDRTTTLTQSNAPPPQKSN
C_intestinalis_ENSCINP00000010464         LRL--------------------WNRSMEVVIPDEEREHEREKEEEKLLAKNQDTTVSGKSRSCTFYNFLRKKRTTVESVRGAEKIMEAIELFNEEKVKEEEFKFINK--NKDVFYKSDH
O_latipes_ENSORLP00000010395              LRL--------------------WERTREPIILEEEREMEREAEFEESVAKGDAPVVPGEVEG----EAAPAAKKTVETVKAAERIMEALELHREELRKMEEHKYACEGAGKQLPPPKPN
T_nigroviridis_ENSTNIP00000007980         LRL--------------------WERTREPVILEEEREMEREAEFEESMAKGDVPVVPGETPG----EAAPAGKKTVETVKAAERIMEALELFREERRKLEDHEYACRAAGRQLPAPKPN
T_guttata_ENSTGUP00000006840              ITL--------------------WQDVTEIEEKEAQAKQEEQIMKEQEL------------------SNLLHEKRYLKALCLAISLDRPHTVLTVVKAILREPEGR--------------
T_nigroviridis_ENSTNIP00000004057         ITV--------------------WEDVTEIEMAEEQAKQEEHILKQQEL------------------SNLLQEKKYLKALGLAISLDQPHTVLTVIKAIRQTEDNS--------------
M_domestica_ENSMODP00000008927            IKW--------------------QVK-KEGLLLDIFSLGHDLQLNQQD-------------------SHNLLSGMDLAPDRCSLILAKPLLGML-LKVDSTPSEFWHKLSLHSLTLFSTH
D_rerio_ENSDARP00000023281                LRL--------------------WERTREPIILEEEKEMEREAEFEESLAKGDDPVVPGETKG----EAEPAGRKTVETVKAAERIMEAIELYREESKNLEEHKAACEAAGKKLPPLKMN
G_gallus_ENSGALP00000008904               ITL--------------------WKDVTEIEQEEAQAKREEQIMKEQEL------------------SNLLHEKRYLKALGLAISLDRPHTVLTVIKAILKESDGR--------------
G_aculeatus_ENSGACP00000015863            ITL--------------------WMDVTEVELAEEQAKQEDQILKQQEL------------------SNLLHEKKYLKALGLAISLDQPRTVLTVIKAIRQVQDSH--------------
A_aegypti_AAEL004526-PA                   LIK--------------------WKDVTDEKREREMNERKEVLLQEQEL------------------NNLLQDKKLLKALRLALNLDRPLMTLKIITSVIKSQE----------------
M_musculus_ENSMUSP00000060613             LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEDQPAVPGETQG----DNYFTGKKTIETVKAAERIMEAIELHREETAKMKEHRAICKAAGKEVPLP-VN
H_sapiens_ENSP00000262715                 SEW--------------------QVKLRKGSAPGNLSLHLNRIL--QE-------------------DLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STH
T_rubripes_ENSTRUP00000017221             ITV--------------------WEDVTEMEVAEEQAKQEEQILKQQEL------------------SNLLQEKKYLKALGLAISLDQPHTVLTVIKAIRQTEDSS--------------
C_intestinalis_ENSCINP00000019387         ISF--------------------WKDVTDEQRREDIEAKQKTMLHHQEL------------------QNLLQEKKYEKALHFAIKLSQPFTALNVIKELMWETDGY--------------
G_gallus_ENSGALP00000023833               LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEEQPVVAGETQG----ETGLAGKKTIETIKAAERIMEAIELYREEMAKLKEHKAICKAAGKEVPFP-AN
P_troglodytes_ENSPTRP00000010340          SEW--------------------QVKLRKGSAPGNLSLHLNRIL--QE-------------------DLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSNYTENPMIL-STH
T_guttata_ENSTGUP00000013749              LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEEQPVVPGERQG----ETGLAGKKTIETIKAAERIMEAIELYREETAKLKEHNAICKAAGKEVPFP-VN
T_rubripes_ENSTRUP00000006345             LRL--------------------WERTREPVILEEEREMEREAEFEESMSKGDIPVVPGEAPG----EAAPAGKKTIETVKAAERIMEALELFKDENRKMEEHKYVCEAAGKQLPPPNPN
H_sapiens_ENSP00000308179                 LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN
R_norvegicus_ENSRNOP00000012235           SEW--------------------QVELRKGSTCTNFRLYLKRVL--QE-------------------DLGVLTGMALAPDGQSLILMKEDVELLQMKPGSTPSSICRRYAVHSSIL-CTS
D_melanogaster_FBpp0085899                LPVICLHNTPAQYVKLP-TYSGPSKDVEDLRPQGPKRQMKRLLKKEVSL------------------DTYTWQKKY-GHLTSSVMMAQVDERLKRRFSVSASMEEISKIAETKTGASQAN
P_troglodytes_ENSPTRP00000001997          LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN
M_mulatta_ENSMMUP00000011166              LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHTAICKAAGKEVPLP-TN
M_domestica_ENSMODP00000006461            LRL--------------------WERTKEPLILEEEQEMQREAEYEDSVAKEDQPVVPGEAQG----DSYFPGKKTVETVKAAERIMEAIELYREETAKMKEHEAICKAAGKEVPLP-VN
P_pygmaeus_ENSPPYP00000001131             LRL--------------------WERTREPLILEEEREMEREAEYEESVAKEDQPAVPGETQG----DSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAICKAAGKEVPLP-SN
M_mulatta_ENSMMUP00000021364              SEW--------------------QVKLRKGSAPGNFSLHLNRIL--QE-------------------DLGVLTSLGWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMIL-STH
B_taurus_ENSBTAP00000026561               LRL--------------------WERTREPLILEEEKEMQREAEYEESVAKEDQPAVPGETQG----DNYFTGKKTIETVKAAERIMEAIELYREETAKLREHKAICKAAGKEVPLP-IN
R_norvegicus_ENSRNOP00000026726           LRL--------------------WERTREPLILEEERELQREAEYEESVAKEEQPAVPGETQG----DNYFTGKKTIETVKAAERIMEAIELYREETAKMKEHRAICRAAGKEVPLP-VN
A_gambiae_AGAP009615-PA                   LIQ--------------------WQDVTESKRQQELDQRKDTLLQEQEL------------------SNLLSERKLLKALRLSLNLDRPLSTLKIVNEVIRTKE----------------
B_taurus_ENSBTAP00000027147               VVL--------------------WKDVTEAEQAEEQAKREEQVVKQQEL------------------DNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPESC--------------
X_tropicalis_ENSXETP00000035244           SRW---------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   LRL--------------------YERTEEPLVLQDVQEEEREELENNTLATGEESTVPGLP------GLKLPSKKTIGAEKAAENILECLEVSK--KFEEEDTKNIIP------------
O_anatinus_ENSOANP00000004860             LRL--------------------WERTREPLVLEEEREMQREAEYEDSVAKEDQPVVPGEAQG----EASLAGKKTIQTVKAAECIMEAVELFREETAKRAEHAAVCKAAGKEVPLP-PN
E_caballus_ENSECAP00000005446             LRL--------------------WERTREPLILEEEREMQREAEYEESVAKEDQPAVPGETQG----DNYFTGKKTIETVKAAERIMEAVELYREETAKMKEHKAICKAAGKEVPLP-IN
S_cerevisiae_YLR222C                      FQF--------------------WKDCTEQEIEEEQEKAKLQVEQEQSL------------------QNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIF--
E_caballus_ENSECAP00000009299             SEW--------------------QVEWQKDSTPGNFSLHLKQVL--QE-------------------DLGFLTGMALAPDGHSLILAKADLHLLRMKPGDAPSEIWTSFGEHPIML-STH
X_tropicalis_ENSXETP00000021860           LRL--------------------WERTREPLILEEEKEMQREAEYEESVAKGQQPVVAGEREG----EVGLAGKKTIETVKATERIMEAIELHREETAKLEEHRALCKAAGKELPHR-TH
A_gambiae_AGAP004827-PA                   LPIICLHNSPASYIKLP-TYSAPARDVEDLRPAGPKRPARRLLKKEVSL------------------DTYTWQKKY-AHLTSSVMMAQVDERLKRRFSVSASMEEISKLAEAKNVESQAT
M_domestica_ENSMODP00000027702            ILL--------------------WKDVTETEQAEEQARQEEQILKQQEL------------------SNLLQEKQYLRALGLAISLDRPHTVLTVIKAILKEVEGP--------------
X_tropicalis_ENSXETP00000015707           IIL--------------------WKDVTETELAEEQAKEDEAILKQQEL------------------SNLLHEKRFLKALGLAISLDQPHTVLTVVKAILQEPHGK--------------
M_mulatta_ENSMMUP00000010429              VIL--------------------WK---VAEQAEEQARQEEQVVRQQEL------------------DNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEAC--------------
B_taurus_ENSBTAP00000001564               SEW--------------------QVELQKGSTPRNVSLRLNRVL--QE-------------------DLGFLTSVGLAPDAHSLILAKADLQLLHMKPGDEPSVIWQSYSEDPMML-STH
A_aegypti_AAEL001276-PA                   LPIICLHNSPASYIKLP-TYSAPARDVEDLRPAGPKRPARRLLKKEVSL------------------DTYTWQKKY-AHLTSSVMMAQVDERLKRRFSVSASMEEISKLAESKTMESQQN

                                                 2890      2900      2910      2920      2930      2940      2950      2960      2970      2980      2990      3000
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      MCTLL-------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ---------------PILRAYGNITVS--VMFFYFRLRDIELEESLLVLPFSYVPDLLQLLGTFVARGR---------------------------------------------------
O_latipes_ENSORLP00000010395              ---------------PVLVAFGNVSPARYVLDVIKAVRSSELEVSLLVLPFPYVPELLQLFSSYIHQGL---------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         ---------------PILVAYGNVTPSRYVLDVIKKVRSSELEVSLLVLPFSYVPELLKLFNAYIQQGL---------------------------------------------------
T_guttata_ENSTGUP00000006840              ---------------------------------------RHLEENIVRLRKDQKEAVLAFLVTWNTNSR---------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         ---------------------------------------ELLEKTVLKLRVDQKEALLRFCVAWNTNAK---------------------------------------------------
M_domestica_ENSMODP00000008927            ---------------EEHGVFSLDTLR-NVLSIHQQTESSVLEHIKDFDLQLENPRGTPLWITQAKPESGFNSALGMADSAFLCASSEGVLWNMAECTPEGDWVTDNIWQDTEEEFD---
D_rerio_ENSDARP00000023281                ---------------PILMAFGNISPSRYVLEVMKKVRSSELEVSLLVLPFPYVPDLLKLFNAYVKEGL---------------------------------------------------
G_gallus_ENSGALP00000008904               ---------------------------------------KRLEENIARLRKDQKEAVLTFLVTWNTNSR---------------------------------------------------
G_aculeatus_ENSGACP00000015863            ---------------------------------------KLLEKTVLKLRVDQKESLLRYCAVWNTNAR---------------------------------------------------
A_aegypti_AAEL004526-PA                   ---------------------------------------QGLPDTIQKLRNDHKETLLKHAIEWNTNSK---------------------------------------------------
M_musculus_ENSMUSP00000060613             ---------------PILMAHGNISPSAYVLETFKGIRSSELEEALLVLPFSYVPDVLTLFNEFIQTGL---------------------------------------------------
H_sapiens_ENSP00000262715                 ---------------KEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQT
T_rubripes_ENSTRUP00000017221             ---------------------------------------ELLEKTVLKLRVDQKEALLRYCGVWNTNAK---------------------------------------------------
C_intestinalis_ENSCINP00000019387         ---------------------------------------DFLNKYLSILRLDQKSELLKFVVSWNTNSR---------------------------------------------------
G_gallus_ENSGALP00000023833               ---------------PILRAYGNITPSEYVLEVFKKVKSSELEESLLVLPFSYVPDLLRLFNEYIQLGA---------------------------------------------------
P_troglodytes_ENSPTRP00000010340          ---------------KEYGIFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTTGNIWQKKANTPETQT
T_guttata_ENSTGUP00000013749              ---------------PILRAYGNITPSAYVLEVFKKVKSSELEESLLVLPFSYVPDLLRLFNEYIQQGS---------------------------------------------------
T_rubripes_ENSTRUP00000006345             ---------------PILVAFGNISPSRYVLDVIRKVRSSELEVSLLVLPFSYVPELLKLFNGYIQQGL---------------------------------------------------
H_sapiens_ENSP00000308179                 ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------------------------------------------------
R_norvegicus_ENSRNOP00000012235           ---------------KDYGLFYLQQGNSGSLSILEQEESGKFEKTLDFNLNLNNPNGSPVSITQAEPES---------GSSLLCATSDGMLWNLSECTPEGEWVVDNIWQKKSRNPKSRT
D_melanogaster_FBpp0085899                LGPEQAALAQSQHFDQLEALWNKRSPPRRRHNAGLSRQTSLVEDRLESSDDDEYQDERAGMLSASYDNIHHLARLPGLRSLHDAWKTNSLRVPSRSARTKFYVSTPPPQNSQNSSSLRLD
P_troglodytes_ENSPTRP00000001997          ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------------------------------------------------
M_mulatta_ENSMMUP00000011166              ---------------PILMAYGSISPSAYVLEIFKGIRSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------------------------------------------------
M_domestica_ENSMODP00000006461            ---------------PILMAYGNILPSAYVLEVFKGIKSSELEEALLVLPFSYVPDILKLFDEFFQLGS---------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGS---------------------------------------------------
M_mulatta_ENSMMUP00000021364              ---------------KEYGVFVLQPKDPGVLSFLRQKESGEFEERLNFDINLENPSRTLISITQAKPES---------ESSFLCASSDGMLWNLAKCSPEGEWTTGNIWQKKANIPETQT
B_taurus_ENSBTAP00000026561               ---------------PILMAYGNISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILRLFNEFIQQGS---------------------------------------------------
R_norvegicus_ENSRNOP00000026726           ---------------PILMAHGNISPSAYVLETFKGIRSSELEEALLVLPFSYVPDILTLFNGFIQTGS---------------------------------------------------
A_gambiae_AGAP009615-PA                   ---------------------------------------QGLEDTVRKLSNDHKERLLRHAIEWNTNSK---------------------------------------------------
B_taurus_ENSBTAP00000027147               ---------------------------------------EKLETTVLQLRRDQKEALLRFCVTWNTNSR---------------------------------------------------
X_tropicalis_ENSXETP00000035244           ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   ---------------PLMYAYEATNTDDFLLAVLTRIRASDLEEALLLLPFSAVCELLERIPKLTETRQ---------------------------------------------------
O_anatinus_ENSOANP00000004860             ---------------PLLQALGNISPSDYVLEVLKKVKSSELEESLLVLPFSYVPDLLLLFNQFIQLGQ---------------------------------------------------
E_caballus_ENSECAP00000005446             ---------------PILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDLLTLFNELIQLGS---------------------------------------------------
S_cerevisiae_YLR222C                      --------------------------------------NEELDQAISILNDEQLILLMKRCRDWNTNAK---------------------------------------------------
E_caballus_ENSECAP00000009299             ---------------QDYGVFILQPTASGALSVLRQKESGEFEETLDFCVNLENPGGTLTLVTQAKPES---------ESSFLCASSDGMLWNLAKCTLEGQWTTDNIWQKEAKMPETQT
X_tropicalis_ENSXETP00000021860           ---------------PILQAYGNISPSDYVLDVFKKVKSSELEESLLVLPFSYVSDALALFRDYIRQGR---------------------------------------------------
A_gambiae_AGAP004827-PA                   LGPEQAALAQSQHFDQLEALWNKRSPPRRRLNASLSRQSSLVEDRIDSSDEDEFQEERAGM--SKKLALFHASRPLSLSV--DAWNCSSLYSSTSSTNTQY---NQPNHHQQHHYYQHHH
M_domestica_ENSMODP00000027702            ---------------------------------------KKLEEKVLKLRKDQKEALLRFLVTWNTNSR---------------------------------------------------
X_tropicalis_ENSXETP00000015707           ---------------------------------------DDLEKNIERLRQDQKESILRYCCVWNTNSR---------------------------------------------------
M_mulatta_ENSMMUP00000010429              ---------------------------------------EKLEATMLRLRRDQKEALLRFCVTWNTNSR---------------------------------------------------
B_taurus_ENSBTAP00000001564               ---------------QDYGVFVLQSMKLQVLPFSGQKELGEFEECLEFDLNLENPSNTLISVTQAKPGS---------ESSFLCASSDGMLWNLARCTDEGEWITDNIWQKKAEMPSTQS
A_aegypti_AAEL001276-PA                   LGPEQAALAQSQHFDQLEALWNKRSPPRRRVNASLSRQSSLVEDRIESSDEDEFLEERAGT--SKRHK-FISMRPVSLPV--DAWHYSSFFHSS------F---THHHHHNQNQSHQH--

                                                 3010      3020      3030      3040      3050      3060      3070      3080      3090      3100      3110      3120
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+
H_sapiens_ENSP00000353059                 ------------------------------------------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          ------------------------------------------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             ------------------------------------------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              ------------------------------------------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             ------------------------------------------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               ------------------------------------------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           ------------------------------------------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             ------------------------------------------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             ------------------------------------------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            ------------------------------------------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           ------------------------------------------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              ------------------------------------------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               ------------------------------------------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         ------------------------------------------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              ------------------------------------------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           ------------------------------------------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            ------------------------------------------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                ------------------------------------------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             ------------------------------------------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         ------------------------------------------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            ------------------------------------------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              ------------------------------------------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      ------------------------------------------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         ----------------------------EVELACRCIFFLLRIHHGRITTNQTLVNVLDDLRHNTETKIDQLRNTIGFNLAALGHIRRQFESKNDVTFFSDATQRANDKKKRRKRTTQRA
O_latipes_ENSORLP00000010395              ----------------------------EVELVCRCLFFLLKIHFGQITSNQMLLSVIDDLHSVTVSKVCEIRDVMGFNSAALQFLQRQIESQENVTFFAEATGRQTMNNREQKITQRST
T_nigroviridis_ENSTNIP00000007980         ----------------------------EVELVCRCLFFLLRIHFGQISSNQMLLTVMDQLRTNTLARVGQIRDVMGFNSAALQFLQRELESKEEVTFFAEATGKLKKVKLKGRRVEPRV
T_guttata_ENSTGUP00000006840              -----------------------------------------NCHEAQAVMETLLKHEAPDSLLQFSGIKSAVESLLPYTERHFQRLSRLLQASTFIEFMWQNMRLA--------------
T_nigroviridis_ENSTNIP00000004057         -----------------------------------------NCQDAQVVLQVLLTHVPPEELLQYQGARTHLEALVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSS-DASVTRRV
M_domestica_ENSMODP00000008927            --------------------------FPKLKTQYSKKIHSGSVTALHVLPKVLLTASEDRDVKLWEKPNLQLRGLFRCEGAVSCVEPRPGPGPTLQLAVGDAQGHVYFLSWE--------
D_rerio_ENSDARP00000023281                ----------------------------EVELVCRCLFFLLRVHFGQITSNQMLLSVIDELRANTISKVREIRDVLGFNSAGLQFLQREIESREDVTFFADATDRFEEKRRKRRKRERVI
G_gallus_ENSGALP00000008904               -----------------------------------------NCHEAQAVIETLLKHEAPDNLLQYSGIKSAVESLLPYTERHFQRLSRLLQASMFIDFMWQNMKLSDVSQQEDMIL----
G_aculeatus_ENSGACP00000015863            -----------------------------------------NCQDAQAVLQVLLTHLPPEELLQYQGARTHLEGLIPYTERHMQRIGNLLQASMFLNYMWQKMRVAGAPSSMNRDEEMDT
A_aegypti_AAEL004526-PA                   -----------------------------------------NCRPAQLVLNILLQQMLSGEF-QVSELNKHLEAALPYTERHFKRMTEYAKDLKFIEYTLHCMQPHATTREANKTDKV--
M_musculus_ENSMUSP00000060613             ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLKETTISKVRQVQDAIGFNMAGLDYLKRECEAKSEVMFFAEATSHLEEKKKKRKNRKRMI
H_sapiens_ENSP00000262715                 PGTDPSTCRESDASMDSDASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE--------
T_rubripes_ENSTRUP00000017221             -----------------------------------------NCQDAQVVLQVLLTHVPPEELLQYQGARTHLEGLVPYTERHMQRIGRLLQASMFLNYMWQKMRVVGEPSSMDQDEEMDT
C_intestinalis_ENSCINP00000019387         -----------------------------------------NCHEAHAVLKALLSNTAPEDFEQIENYQSVIESLLPYTERHFHRMNKISQQATFVDYTWQLIKMK--------------
G_gallus_ENSGALP00000023833               ----------------------------EIELLCRALLFLLKIHFGQITGNQMLVTVIENLKKTTISRVSEARDVLGFNMAGLQYLKREIEAKDEVMFFADATDRFEEKKRKRKKKEKMI
P_troglodytes_ENSPTRP00000010340          PGTDPSTCWESDASMDSHASMDSEP-TPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE--------
T_guttata_ENSTGUP00000013749              ----------------------------DVELLCRALLFLLKIHFGQITGNQMLVTVIENLKKTAISRVSEARDVLGFNMAGLQFLKREIEAKEEVTFFADATERFEEKKRKRKKKEKMV
T_rubripes_ENSTRUP00000006345             ----------------------------EVELVCRCLFFLLRIHFGQISSNQMLLTVMDQLRTNTVAQVRQIRDVMGFNSAALQFLQREIESREEVTFFAEATGKLKERKRRRTKRERVV
H_sapiens_ENSP00000308179                 ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
R_norvegicus_ENSRNOP00000012235           PGTDSSPGL---------FCMDSWVEPTHLKARQCKKIHLGSVTALHVLPGLLVTASEDRDVKLWERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDAQGNLYFLSWE--------
D_melanogaster_FBpp0085899                SHVPGQFTDGVVAPDLVRDLLSVPPTVESPQR--------------ISLRQLLHWPSLKSRIWRRQRNC---QSLQPNIRLNPPERLRPTPIIVVENYDVRRVQQLRTDLILHPQTSRAS
P_troglodytes_ENSPTRP00000001997          ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
M_mulatta_ENSMMUP00000011166              ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
M_domestica_ENSMODP00000006461            ----------------------------NIELLCRCLFFLLRIHFGQISSNQMLVPVIEKLKKTTISKVSEVRDIIGFNMAGLEFLKRECEAKSEVEFFSDATNSFEEKKRKRKKREKLI
P_pygmaeus_ENSPPYP00000001131             ----------------------------DVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
M_mulatta_ENSMMUP00000021364              PGADPSTCRESD------ASMDSEP-TSQLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE--------
B_taurus_ENSBTAP00000026561               ----------------------------DIELLCRCLFFLLRIHFGQITSNQMLVPVIEKLKETTISKVSQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
R_norvegicus_ENSRNOP00000026726           ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLKETTISKVRQVQDVIGFNMAGLNYLKRECEAKSEVMFFAEATSHLEEKKRKRKNRRKMI
A_gambiae_AGAP009615-PA                   -----------------------------------------NCRPAQLALNVLLQETLAGRF-QVSELNKHLEASLPYTERHFKRLTEYVKDLKFVEYSLRCMQPHAARMD---------
B_taurus_ENSBTAP00000027147               -----------------------------------------HCHEAQAVLGVLLRHEAPDELLTYDGVRASLEGLLPYTERHFQRLSRMLQAATFLDFLWHNMKLPALPTAPAAL-----
X_tropicalis_ENSXETP00000035244           ------------------------------------------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   ---------------------------DQTETICKVVLFLFRIHQKPIVNNQMLLPVIQEIIGKLQGAIVGLRDMIGVNFHGMQMLQREVEANQGVELFRDATKTRRQKDMRRKRKEAAA
O_anatinus_ENSOANP00000004860             ----------------------------DVELLCRCLLFLLRVHFGQITNNQMLVPAIEKLKETTVSKVGHVRDNIGFNIAGLEFLKREIEAREDVTFFADATDRVAERRRKRKKREKLV
E_caballus_ENSECAP00000005446             ----------------------------DVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLKETTISKVRQVRDVIGFNMAGLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLI
S_cerevisiae_YLR222C                      -----------------------------------------THTIAQRTIRCILMHHNIAKLSEIPGMVKIVDAIIPYTQRHFTRVDNLVEQSYILDYALVEMDKLF-------------
E_caballus_ENSECAP00000009299             PGTDPSID----------TDVDSWPRTTDLKTQQRRKIHSGSVTALHVLPELLVTASKDRDVKLWERPSMQLLGLFRCEGAVSCLEPWLGPDSTLQLAVGDMQGNVYFLSWE--------
X_tropicalis_ENSXETP00000021860           ----------------------------DVELICRCLFFLLRIHFGQITSNQMLLGVIEDLKNCTISRVAEVRDMMGVNMAALQFLKREVGAREEVQFFADATERFEEKKRKRKKNEKLL
A_gambiae_AGAP004827-PA                   RH----------QPDLLREVLLLKKQHSVPTG-------GTSGYSGDPFGGQLKLSSTETDLQALFRHC-TFGTLSCHSRRR--QSSPENEQYHVRRRMSRSIDNLNHEVAVFNQQCRRN
M_domestica_ENSMODP00000027702            -----------------------------------------HCHEAQAVLGVLLQHESPEELLTYEGIQASLEALLPYTERHFQRIGRTLQAAMFLDFLWQTMKLPETSAIPT-------
X_tropicalis_ENSXETP00000015707           -----------------------------------------NCHEAQSVLSIILTHEPPESLLQFSGIRGSLESLIPYTERHMQRMGRLLQASMFVDFMWQHMRLTDLPEEDKAPGSI--
M_mulatta_ENSMMUP00000010429              -----------------------------------------HCHEAQAVLGVLLRREAPEELLAYEGVWAALEALLPYTERHFQRLSRTLQAAAFLDFLWHNMKLPVLAATPTPWETHKE
B_taurus_ENSBTAP00000001564               SETESCIC----------TNTYSWSTVTELKTQQRRKIHSGPVTALHVLPELLVTASKDRDVKLWERPSMRLLGLFQCEGAVSCLEPWLGPDSTLQLAVGDTQGNVYFLSWE--------
A_aegypti_AAEL001276-PA                   -------------PDLLREVLLLKKQHSTPAPTLPHDDIGLTGSSVES-RRKLKMSSTETDLQSFFGNCTTFGSLYCNARRKHAQQSPECESRAYMRRQSRSIENLR-----YGDEARLR

                                                 3130      3140      3150      3160      3170      3180      3190      3200
                                          =========+=========+=========+=========+=========+=========+=========+=========+=========
H_sapiens_ENSP00000353059                 -----------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000042795          -----------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000005543             -----------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000038848              -----------------------------------------------------------------------------------------
E_caballus_ENSECAP00000022364             -----------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000028867               -----------------------------------------------------------------------------------------
C_familiaris_ENSCAFP00000009806           -----------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000020157             -----------------------------------------------------------------------------------------
O_anatinus_ENSOANP00000008896             -----------------------------------------------------------------------------------------
M_domestica_ENSMODP00000009538            -----------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000010869           -----------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000009081              -----------------------------------------------------------------------------------------
G_gallus_ENSGALP00000037436               -----------------------------------------------------------------------------------------
A_carolinensis_ENSACAP00000012965         -----------------------------------------------------------------------------------------
G_gorilla_ENSGGOP00000008216              -----------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000014654           -----------------------------------------------------------------------------------------
O_cuniculus_ENSOCUP00000010200            -----------------------------------------------------------------------------------------
D_rerio_ENSDARP00000008347                -----------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000033561             -----------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000013938         -----------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000026214            -----------------------------------------------------------------------------------------
O_latipes_ENSORLP00000019346              -----------------------------------------------------------------------------------------
C_elegans_Y45F10B.10                      -----------------------------------------------------------------------------------------
C_intestinalis_ENSCINP00000010464         VLTT-------------------------------------------------------------------------------------
O_latipes_ENSORLP00000010395              INRS-------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000007980         SDLN-------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000006840              -----------------------------------------------------------------------------------------
T_nigroviridis_ENSTNIP00000004057         SARIQA-----KEGN-RANSQQH------------------------------------------------------------------
M_domestica_ENSMODP00000008927            -----------------------------------------------------------------------------------------
D_rerio_ENSDARP00000023281                LTIT-------------------------------------------------------------------------------------
G_gallus_ENSGALP00000008904               -----------------------------------------------------------------------------------------
G_aculeatus_ENSGACP00000015863            TPLAQPFLMIDKDEDPNDAVKEDEDDEEVSASNKASTNTGSVENGASPQTDGNHHCESEQSSEEEDPEEVNVMKCLPVPTALKCQTFAS
A_aegypti_AAEL004526-PA                   -----------------------------------------------------------------------------------------
M_musculus_ENSMUSP00000060613             LTLT-------------------------------------------------------------------------------------
H_sapiens_ENSP00000262715                 -----------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000017221             SPLVQPFFTIDKDSE-ESSEEEDMDEEEEEAGKAAKRL---------------------------------------------------
C_intestinalis_ENSCINP00000019387         -----------------------------------------------------------------------------------------
G_gallus_ENSGALP00000023833               LAVV-------------------------------------------------------------------------------------
P_troglodytes_ENSPTRP00000010340          -----------------------------------------------------------------------------------------
T_guttata_ENSTGUP00000013749              LAVL-------------------------------------------------------------------------------------
T_rubripes_ENSTRUP00000006345             LTIA-------------------------------------------------------------------------------------
H_sapiens_ENSP00000308179                 LTLT-------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000012235           -----------------------------------------------------------------------------------------
D_melanogaster_FBpp0085899                VGHIEVAGSEHLLAKKANYWQRRWHLLRHKAASTTTTTTSRSESSHPHRDSMNSHSNNSTPDPTANCNDCVAQ----------------
P_troglodytes_ENSPTRP00000001997          LTLT-------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000011166              LTLT-------------------------------------------------------------------------------------
M_domestica_ENSMODP00000006461            MTLA-------------------------------------------------------------------------------------
P_pygmaeus_ENSPPYP00000001131             LTLT-------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000021364              -----------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000026561               LTVT-------------------------------------------------------------------------------------
R_norvegicus_ENSRNOP00000026726           LTLT-------------------------------------------------------------------------------------
A_gambiae_AGAP009615-PA                   -----------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000027147               -----------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000035244           -----------------------------------------------------------------------------------------
A_aegypti_AAEL004364-PA                   KRAFVQIST--------------------------------------------------------------------------------
O_anatinus_ENSOANP00000004860             LAMT-------------------------------------------------------------------------------------
E_caballus_ENSECAP00000005446             LTLT-------------------------------------------------------------------------------------
S_cerevisiae_YLR222C                      -----------------------------------------------------------------------------------------
E_caballus_ENSECAP00000009299             -----------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000021860           LAVV-------------------------------------------------------------------------------------
A_gambiae_AGAP004827-PA                   -------------------------------------PMSRS---------------------------CLMQ----------------
M_domestica_ENSMODP00000027702            -----------------------------------------------------------------------------------------
X_tropicalis_ENSXETP00000015707           -----------------------------------------------------------------------------------------
M_mulatta_ENSMMUP00000010429              ALP--------------------------------------------------------------------------------------
B_taurus_ENSBTAP00000001564               -----------------------------------------------------------------------------------------
A_aegypti_AAEL001276-PA                   -------------------------------------RKYRS---------------------------CLMQ----------------