>H_sapiens_ENSP00000351486 -------------------------------------------MLRGGRRGQLGWHSWAA GP--GSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDG-ALDSLHHLPG---------- -------AENLTEL------------------YIENQQHLQHLE-----LRDLRGLGELR NL--TIVKSGLRFVAPDAFHFTPRLSRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALRWLQRWEEEGLG-GVPEQKLQCHGQG------------------- ------------------------------------------------------------ -----------PLAHMPNA----SC---GV--PTLKV-QV-PNASVDVGDD-V------- -----------------------------------------------------LLRCQVE GRGLEQAG-------WILTE-----LEQ--SATV-------MKS---GGLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-QLHTAVE-- -MHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPA--ANETVRHGC LRLNQPTHVNNGNYTLLAANPFGQASASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PFGVSVA----VGLAVFACLFLSTLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EASESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IDCI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_troglodytes_ENSPTRP00000002496 -------------------------------------------MLRGGRRGQLGWHSWAA GP--GSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDG-ALDSLHHLPG---------- -------AENLTEL------------------YIENQQHLQHLE-----LRDLRGLGELR NL--TIVKSGLRFVAPDAFHFTPRLSRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALRWLQRWEEEGLG-GVPEQKLQCHGQG------------------- ------------------------------------------------------------ -----------PLAHMPNA----SC---GV--PTLKV-QV-PNASVDVGDD-V------- -----------------------------------------------------LLRCQVE GRGLEQAG-------WILTE-----LEQ--SATV-------MKS---GGLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-QLHTAVE-- -MHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPA--ANETVRHGC LRLNQPTHVNNGNYTLLAANPFGQASASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PFGISVA----VGLAVFACLFLSTLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IDCI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_pygmaeus_ENSPPYP00000000808 -------------------------------------------MLRGGRRGQLGWHSWAA GP--GSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDG-ALDSLHHLPS---------- -------AENLTEL------------------YIENQQHLQHLE-----LRDLRGLGELR NL--TIVKSGLRFVAPDAFHFTPRLSRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALRWLQRWEEEGLG-GVPEQKLQCHGQG------------------- ------------------------------------------------------------ -----------PLAHMPNA----SC---GV--PTLKV-QV-PNASVDVGDD-V------- -----------------------------------------------------LLRCQVE GRGLEQAG-------WILTE-----LEQ--SATV-------MKS---GGLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-QLHTAVE-- -MHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPA--ANETVRHGC LRLNQPTHVNNGNYTLLAANPFGQASASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PFGVSVA----VGLAVFACLFLSTLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IDCI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_gorilla_ENSGGOP00000013487 -------------------------------------------MLRGGRRGQLGWHSWAA GP--GSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDG-ALDSLHHLPG---------- -------AENLTEL------------------YIENQQHLQHLE-----LRDLRGLGELR NL--TIVKSGLRFVAPDAFHFTPRLSRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALRWLQRWEEEGLG-GVPEQKLQCHGQG------------------- ------------------------------------------------------------ -----------PLAHMPNA----SC---GV--PTLKV-QV-PNASVDVGDD-V------- -----------------------------------------------------LLRCQVE GRGLEQAD-------WILTE-----LEQ--SATV-------MKS---GGLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-QLHTAVE-- -MHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPA--ANETVRHGC LRLNQPTHVNNGNYTLLAANPFGQASASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PFGVSVA----VGLAVFACLFLSTLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IDCI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_mulatta_ENSMMUP00000016315 -------------------------------------------MLRGGRRGQLGWHSWAA GP--GSLLAWLMLASAGASPCPDACCPHGSSGLRCTRDG-ALDSLHHLPG---------- -------AENLTEL------------------YIENQQHLQHLE-----LRDLRGLGELR NL--TIVKSGLRFVAPDAFHFTPQLSRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALRWLQRWEEEGLG-GVHEQKLQCHGQG------------------- ------------------------------------------------------------ -----------PLAHMPNA----SC---GV--PMLKV-QV-PNASVDVGDD-V------- -----------------------------------------------------LLWCQVE GRGLEQAG-------WILTE-----LEQ--SATV-------MKS---GALPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-ELSVQVNVS------------FPASV-QLHTAVE-- -MHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPA--ANETVRHGC LRLNQPTHVNNGNYTLLAANPFGQASASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PFGVSVA----VGLAVFACLFLSMLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IDCI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >B_taurus_ENSBTAP00000003980 -------------------------------------------MLRGGRGGQPGGHLRAT GP--GSLLAWLMLASAGAASCPDVCCPHGPSGLRCTRPG-ALDNLLHLPG---------- -------AENLTEL------------------YIENQQHLQQLK-----RSDLRGLGELR KL--TIVKSGLRSVAPNAFHYTPRLGRL-------NLSFNA-LESLSWKTVQGLSLQE-- -LVLSGNPLHCSCALLWLQRWEEEGRG-GVREQKLQCPGQG------------------- ------------------------------------------------------------ -----------PLALMSNA----SC---GE--PTLKI-QM-SNASVDVGAD-V------- -----------------------------------------------------LLQCQVE GQGLEQAG-------WILTE-----LEG--SATV-------MES---GSLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSAQVNVS------------FPASV-HLQAAVE-- -QHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLDLA--ANETMRHGC LRLNQPTHVNNGNYTLLATNPLGQAAAWVMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVE-K---------- ---DET-------PFGVSMA----VGLAVFACLFLSTTFLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEKDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT EPQ--------------------------------------------------------A IECI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >C_familiaris_ENSCAFP00000024305 -------------------------------------------MLLSGRRWGQGGSLGPG TPLAGSLLAWLVLASAGAAPCPDVCCPHGPSGLRCTRAG-ALQSLHRLPG---------- -------VENLTEL------------------YIDNQEHLQHLE-----KGEPCGLTCCC TLPSTIVKSGLRSVAPDAFHFTPRLRRL-------NLSFNA-LESLSWKTVQGLPLQE-- -LVLSGNPLHCSCALHWLLRWEEEGLG-GVRGQRLQCPGQG------------------- ------------------------------------------------------------ -----------PLALLSNA----SC---GV--PVLKV-QM-PNASVEVGDD-V------- -----------------------------------------------------LLQCQVE GRGLERAG-------WILPE-----VEE--LATV-------TPS---GDLPSLGLILANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-QLHEAVE-- -LHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTE-----FLEPV--ANETVRHGC LRLNQPTHVNNGNYTLLAANPSGRAAAFVMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---GQT-------PFGVSVA----VGLAVFACLFLSTLFLALNKCGR---------RNKF GGN----------------------------RAVVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRQDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAQLLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >E_caballus_ENSECAP00000007660 -------------------------------------------MLRGGRRGQLGWHGRAT GP--GSLLAWLMLASAGAAPCPDACCPHGPSGLRCTQPG-ALDSLRHLPG---------- -------AENLTEL------------------YIENQQNLQRLE-----RNDLRGLGELR NL--TIVKSGLHFVAPDAFHFTPRLSRL-------NLSFNA-LKSLSWKTVQGLSLQQ-- -LVLLGNPLDCSCALRWLQRWEEEGLG-GVREQKLQCHQQG------------------- ------------------------------------------------------------ -----------PLALMSNT----NC---GV--PLLKV-QV-PNASVDVGDN-V------- -----------------------------------------------------WLQCQVE GQGLEQAG-------WILTE-----LEE--SATV-------MQS---GGLPSLGLTLANV TSDLNR---KNVTCWAENDVGRA-EVSVQVNVS------------FPASV-HLQTAVE-- -QHH-WCIPFSVDGQPAPTLR-WLFNGSVLNETSFIFTE-----FLESA--ANETMRHGC LRLNQPTHVNNGNYTLLATNPYGQDSASVMVA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSRDPVEKK---------- ---DET-------HFGVSVA----VGLAVFACLFLSTLFLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MRHGDLNRFL-RKHGV-VVQVM------C GGDR-E-TG---------GKRRPGRSPSPCSQTQSRLLLLASGPFAHQVPLTLHCCDPQG LSWKCR-GFGRPLEVTRRPAHRQ------------------------------------- -------VGGRTM-PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDVHARLQALVQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_musculus_ENSMUSP00000029712 -------------------------------------------MLRGQRLGQLGWHRPAA GL--GSLMTSLMLACASAASCREVCCPVGPSGLRCTRAG-SLDTLRGLRG---------- -------AGNLTEL------------------YVENQQHLQRLE-----FEDLQGLGELR SL--TIVKSGLRFVAPDAFRFTPRLSHL-------NLSSNA-LESLSWKTVQGLSLQD-- -LTLSGNPLHCSCALFWLQRWEQEGLC-GVHTQTLHDSGPG------------------- ------------------------------------------------------------ ---------DQFLPLGHNT----SC---GV--PTVKI-QM-PNDSVEVGDD-V------- -----------------------------------------------------FLQCQVE GLALQQAD-------WILTE-----LEG--AATV-------KKF---GDLPSLGLILVNV TSDLNK---KNVTCWAENDVGRA-EVSVQVSVS------------FPASV-HLGLAVE-- -QHH-WCIPFSVDGQPAPSLR-WLFNGSVLNETSFIFTQ-----FLESA-LTNETMRHGC LRLNQPTHVNNGNYTLLAANPYGQAAASVMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DGNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSRDPVEKK---------- ---DET-------PFGVSVA----VGLAVSAALFLSALLLVLNKCGQ---------RSKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IMEN-PQYF------------------- ---------SDTCVHHIKRQDIILKWELGEGAFGKVFLA-ECYNLL-------------- NDQDKMLVAVKA---------LK-EASENARQDFQREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGGPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRACPPDVYA-IMRGCWQREPQQRLSMKDVHARLQALAQAP PSYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >R_norvegicus_ENSRNOP00000018961 -------------------------------------------MLRGQRHGQLGWHRPAA GL--GGLVTSLMLACACAASCRETCCPVGPSGLRCTRAG-TLNTLRGLRG---------- -------AGNLTEL------------------YVENQRDLQRLE-----FEDLQGLGELR SL--TIVKSGLRFVAPDAFHFTPRLSHL-------NLSSNA-LESLSWKTVQGLSLQD-- -LTLSGNPLHCSCALLWLQRWEQEDLC-GVYTQKLQGSGSG------------------- ------------------------------------------------------------ ---------DQFLPLGHNN----SC---GV--PSVKI-QM-PNDSVEVGDD-V------- -----------------------------------------------------FLQCQVE GQALQQAD-------WILTE-----LEG--TATM-------KKS---GDLPSLGLTLVNV TSDLNK---KNVTCWAENDVGRA-EVSVQVSVS------------FPASV-HLGKAVE-- -QHH-WCIPFSVDGQPAPSLR-WFFNGSVLNETSFIFTQ-----FLESA-LTNETMRHGC LRLNQPTHVNNGNYTLLAANPYGQAAASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DTNS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSRDPVEKK---------- ---DET-------PFGVSVA----VGLAVSAALFLSALLLVLNKCGQ---------RSKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTEGKGS-------------------GL--------------QGH------------- --------------------------------IMEN-PQYF------------------- ---------SDTCVHHIKRQDIILKWELGEGAFGKVFLA-ECYNLL-------------- NDQDKMLVAVKA---------LK-ETSENARQDFHREAELLT-----MLQHQHIVRFF-- ---------------GVCTEGGPLLMVFEY-MRHGDLNRFL-RSHGP-DAKLL------A GGED-V-AP---------GPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRACPPDVYA-IMRGCWQREPQQRLSMKDVHARLQALAQAP PSYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_domestica_ENSMODP00000020848 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENQKALKHLT-----LSDLSGLRELR NL--TIIHSGLRFVAPDAFRFTPRLSRLGIIKRLINQSIRQ-VESRAWGMGRGSTEAEG- -GVLTGNPLNCSCALQWLQRREEEGTA----QLGFACQS--------------------- ------------------------------------------------------------ -----------YFALMPND----SC---GV--PLLKV-EP-SNITVDVGDN-V------- -----------------------------------------------------TLHCQVE SQSQSWTS-------WNTEE-----LSE--FVTV-------MIC-KTPGKCILTLVLVRY TSSLA----RSLSFLYFNDVGRA-QLSVQVNVS------------FPPKV-QLHHPVS-- -QHH-WCIPFSVDGQPPPTLT-WRFNGFLLNETNFIFTE-----FLEQT--ANETVRHGC LRLNQPTHVNNGNYTLEVSNSGGRAIDSVMAS---------------------------- ------------------------------------------------------------ ------------FMDN-PFQ--FNPE---------------------------------- ------------DPIP---ESGEMS----------------------------------- ------------------------------------------------------------ ---------------------------DHES----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------HHLLSPCSSDPFVSH---------- ---HIL-------LYQVSVA----VGLAVFACLFLSVLLILLNKCGR---------RSKF GIN----------------------------RPAALAPEEGLAMSLHFMT---LGNS--S LSP-EGKGA-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDACVHHIKRRDIVLKWELGEGAFGKVFLA-ECHNLL-------------- PEQDKMLVAVKA---------LK-EVSESARQDFQREAELLT-----VLQHQHIVRFF-- ---------------GVCTEGRPLLMVFEY-MKHGDLNRFL-RSHGP-DAKIL------A NGVG-T-AP---------GPLGLGQLLAVAGQVAAGMVYLASLHFVHRDLATRNCLVGQG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVLLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRACPPEVYA-IMRGCWQREPQQRHSIKDIHARLQALIKAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_gallus_ENSGALP00000021606 -----------------------------------------------------------P AWLRLWLAALLLPPGAAVPPACPAHCRCPASHTLRCREPLTVSSLSALLLG--------- -------AHRPTDV------------------IIENQALLTSLT-----RDDTRMLWDLR HL--TISNSGLQYISDDAFQDNHRLSHPS------TLGIPG-LVQPGMHCMQLVSSPHL- -SILEGNPFNCSCGIRWLQLWQNGSRA-ELGNQSLLCWEG-------------------- ------------------------------------------------------------ -------SMLVALDSHPLH----DC---EP--PTARI-EH-PDVVLRQGDS-V------- -----------------------------------------------------NLTCHIW GEPSATGE-------WVLPH-----VGS--EPSL-------S-------EWELVLEINNI SSSLNH---KDLTCRAENAVGLA-EDSVMLNVT------------FPPVILLLSEAIP-- -QHF-WCIPFSVDSNPTPRIL-WLFNGSMLPEGPYIHTR-----IVEYE--PNSTVLHGC LQLNRPTHVNNGNYTLVVQNPLGRATRSIQGR---------------------------- ------------------------------------------------------------ ------------FMDN-PFS--FSPE---------------------------------- ------------EPIP---VSISPL----------------------------------- ------------------------------------------------------------ ---------------------------GTRN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SSLEGPVETA---------- ---DEH-------TFGVSVA----VALAVFASLFLSVMLIALNKCGH---------RSKF GIN----------------------------RSAVLAQEDDLAMSLHFMN---LGSS--P VSSTESKLD-------------------GL--------------KSN------------- --------------------------------FIEN-PQYF------------------- ---------CNACVHHVQRRDIVLKWELGEGAFGKVFLA-ECSHLL-------------- PEQEKTLVAVKA---------LK-EVTESARLDFQREAELLT-----VLQHEHIVKFY-- ---------------GVCTEGEPLIMVFEY-MKHGDLNRFL-RSHGP-DAKIL------D QGQG-Q-PC---------GQLTLSHMLQIATQIASGMVYLASLHFVHRDLATRNCLVGHD LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRTCPSEVYD-IMQSCWQREPQQRQRIQDIHSRLQALVKTP PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_cuniculus_ENSOCUP00000009215 -------------------------------------------MLRGGRRWQLGWHSQAT GP--GTLLAWLMLASAGAALCPDVCCPRGPSGLLCTRPG-ALDRLRHLPG---------- -------IENLTEL------------------YLENQ-NLQHLT-----LGDLRGLRELR NL--AIVNSGLQSVATDAFRFTPRLSHL-------NLSFNA-LESLSWKTVQGLPLQE-- -LVLSGNSLRCSCALRWLQRWEEEGLA-GVREQKLRCSESE------------------- ------------------------------------------------------------ -----------PLALMPNA----SC---GM--PTLKV-QM-PNGSVDVGDS-V------- -----------------------------------------------------FLQCQVE GQGLEKAG-------WSLTE-----LEE--LATV-------MKS---EDLPTLRLTLANV TSDLNR---KNVTCWAENDVGRT-EVSVQVNVS------------XXXXX-XXXXXXX-- -XXX-XXXXXXXXXXXXXXXX-XLFNGSVLNETSFIFTE-----FLEPA--ANETMRHGC LRLNQPTHVNNGNYTLLATNPSGQAAASIMAA---------------------------- ------------------------------------------------------------ ------------FMDN-PFE--FNPE---------------------------------- ------------DPIP---VSFSPV----------------------------------- ------------------------------------------------------------ ---------------------------DANS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSGDPVEKK---------- ---DET-------PCGVSVA----VGLAVFACLFLSTLLLVLNKCGR---------RNKF GIN----------------------------RPAVLAPEDGLAMSLHFMT---LGGS--S LSPTDGKGS-------------------GL--------------QGH------------- --------------------------------IIEN-PQYF------------------- ---------SDAXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXX-------------- XXXXXXXXXXXX---------XX-XXXXXXXXXXXXXXXXXX-----XXXXXXXXXXX-- ---------------XXXXXXXXXXXXXXX-XXXXXXXXXX-XXXXX-XXXXX------X XXXX-X-XX---------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXX-XXXXXXXXXXXXXXX-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TKGR--ELERPRACPPEVYA-IMQGCWQWDPQQRHSIKDVHARLQALAQAP PVYLDVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >A_carolinensis_ENSACAP00000014799 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VIENQTTLINLT-----LEDMKNPRELK NL--TISKTRLQFIAPDAFRASPNLTHV-------NLGYNR-LQFLSWRVFHHLRLQE-- -LVLTGNPFRCACGLRWLQLWLVGKQAESMGNQSLSCEGDD------------------- ------------------------------------------------------------ -------GVEIPVIDMNIR----GC---EV--PQVWL-EY-NSAPMKEGMN-A------- -----------------------------------------------------TLRCHVE GQPPPEVK-------WSVPD-----FGG--HSPH-------ITY---ESASETTLQVFGV SAEFNL---QNITCQAENEAGLS-EGVAQLNVT------------FPAVIRDLGNAVE-- -YHK-WCLPFSVDGNPSPSIR-WQFAGTDLEETTYIHTH-----FFLEG-LRNSTLLHGC LYLDRPTHLSNGNYTLFVRNPLGSDSCTIFQE---------------------------- ------------------------------------------------------------ ------------FMDV-PDA-NFNLV---------------------------------- ------------DPVE---IPTMSN----------------------------------- ------------------------------------------------------------ ---------------------------DYRN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------STERSPVETL---------- ---QEQ-------PIGISVA----VVLAVCACLFLSVMLIILNKCGQ---------SSKF GIS----------------------------RSVALAQEEE--MSLQFMNVGGGGSSS-P LSSVESKLE-------------------TL--------------KTN------------- --------------------------------FIEN-PQYF------------------- ---------CNTSVHHIKRRDIILKWELGEGAFGKVFLA-ECYNLS-------------- PTEEKMLVAVKT---------LK-EATESARLDFQREAELLT-----VLQHEHIVRFY-- ---------------GVCTDGAPLVMLFEY-MKH-DLNRFL-RSHGP-DAKIL------D NGGNGQ-SF---------GQLTLSQMLQIATQIASGMVYLASLHFVHRDLATRNCLVGHN MVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRTCPSEVYD-IMQSCWQREPQQRQNMRAIHHRLQALAKAP PVYLAVL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------S >G_aculeatus_ENSGACP00000017390 ---------------------------------------------------------RAP ALLLPLVLALLALAPAPASGGCPAACRCSFAMLQCLEPD-GIVGVPSLAPQE-------- -------SENVTEI------------------YIENQATLENIT-----DIDLVNYRELR NL--TITFCKLRLISANAFQHILKLQYV-------NLASNS-LEHISWRVFHFLPLLN-- -LVLRENPLVCSCDLHWLQQWQWTERG-YADNQQFSCFSD-------------------- ------------------------------------------------------------ -------GREVLLSSLVID----NC---SL--PEVTIVSF-KDSTIQEGGN-L------- -----------------------------------------------------TFACQVT GSPTPNVR-------WRTDE-----LNS--RFST-------QER-IWGSTLELVLFLTNA SSNDNL---HNLTCEAENQAGPG-GDTVQLDIE------------FPVRIIYLKDAVQ-- -QHH-WCFPFVVDGNPEPQIS-WRYNGVDLKESMYTYTK-----FITDS--GDGSVKHGC LFLNKPTHINNGQYTLIAQNRLGRDEATANGM---------------------------- ------------------------------------------------------------ ------------FMHN-PFD-PFDPE---------------------------------- ------------GIFPDKSSSCPPV----------------------------------- ------------------------------------------------------------ ---------------------------PTNK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SNMDVTENP---------- ---ESR-------AFVVRLSGLPNVGLAVFACTFLLVMILVINKCGQ---------HPKF GIH----------------------------RSSVLGTEDDLAVSLRFMN---FGTS--P PSSDEDS---------------------GLSS---------------------------- --------------------------------FVEN-PQYF------------------- ---------CGISVQNIKRQDIVLKWELGEGAFGKVYLA-ECANLS-------------- PDSDKMLVAIKT---------LK-DANESTRQDFQREAELLT-----VLQHQHIVRFY-- ---------------GVCTDGEPLAMVFEY-MRHGDLNRFL-RAHGP-DARIL------E ETKM-P-PL---------GQLTLPQMLHIAAQIASGMVYLASLHFVHRDLATRNCLVGEG LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESIMYRKFTTESDIWSFGVVLWEIFTCGK-QPWYQLSNS E----------------------------------------------------------A IECI-----TQGR--ELERPRTCPKEVHL-LMQGCWQREPQQRMVIKDLHARLLALVKNP PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_rubripes_ENSTRUP00000032757 ---------------------------------------------------------QAQ VCVPFLLLFLLSLAPAAVLGGCPSSCRCSFAMLQCLEAN-KMTSIPVLSPQE-------- -------SENVTEI------------------YIENQGGLENLT-----LMDLAHYRELR NL--TITSCKLRLISANAFQQNLKLQYV-------NLAFNS-LEHISWRVFHFLPLLN-- -LVLRDNPLVCSCDLHWLQQWQLTDRG-DVNSQMLSCLSG-------------------- ------------------------------------------------------------ -------DQYVPLSTLIID----NC---SL--PVVNI-VS-SQSKIQEGGN-L------- -----------------------------------------------------TFECYVT GRPTPSVR-------WQTEE-----LYS--KFVI-------PKV-NWSSTSELVLHLTNV SSRDNL---HNLTCEAENQAGLG-EDMVQLDIE------------FPVKILFFRDAVK-- -HHN-WCFPFAVDGNPEPTIS-WLYNSQEPKKSKFMYIQ-----FMPDS--GDGSVKHGC LNLNKPTHINNGNYTLIVQNKLGRDEATAFGL---------------------------- ------------------------------------------------------------ ------------FMEN-PFG-TFDPE---------------------------------- ------------GKIV--------V----------------------------------- ------------------------------------------------------------ ---------------------------PTNK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TDTVVKENQ---------- ---ESH-------VFVVSVA----VGLALFACTFLLIMVLIINKCGQ---------HSKF GLH----------------------------RSSVLNTEDDLAVSLRFMN---FGIS--P PSSEEDS---------------------GLSS---------------------------- --------------------------------FVEN-PQYF------------------- ---------CGISVQHIKRQDIVLKWELGEGAFGKVYLA-ECANLS-------------- CDSDRMLVAIKT---------LK-DANESTRQDFQREAELLT-----VLQHQHIVRFY-- ---------------GVCTDGELLAMVFEY-MRHGDLNRFL-RAHGP-DAHIL------E ESKL-P-AL---------GPLTLPQMLHIAAQIASGMVYLASLHFVHRDLATRNCLVGEH LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESIMYRKFTTDSDIWSFGVVLWEIFTYGK-QPWYQLSNS E----------------------------------------------------------F ITAP-----HQSN--DAKRPRVCPNEVYV-LMQGCWQREPQQRMVIKDIHSSLLTMVKNP PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_musculus_ENSMUSP00000037909 --------------------------------------------------MDVSLCPAKC SFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRGLHTLN-----AVDMELYTGLQ KL--TIKNSGLRNIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-RLDSQSLYCISAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLVEPEV-- -RLE-HCIEFVVRGNPTPTLH-WLYNGQPLRESKIIHMD-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNALGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDF---------------------------------- -------------FDFESDASPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >C_familiaris_ENSCAFP00000016839 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWRGLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-KLNNQHLYCINAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVH------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKITHVE-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFPAESTDN---------------------------------- -------------FVSIYDVSPT-P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKVLHALGKAA PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_mulatta_ENSMMUP00000001849 --------------------------------------------------MDVSLCPAKC SFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRSLHTLN-----AVDMELYTGLQ NL--TIRNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-KLNNQNLYCINAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EISEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FILFDEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_troglodytes_ENSPTRP00000012676 ------------------------------------------------------------ -----------------SVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRSLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LQLEQNFFNCSCDIRWMQLWQEQGEA-KLNSQNLYCINTD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EISEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTISGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FILFDEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFVMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_pygmaeus_ENSPPYP00000007657 --------------------------------------------------MDVSLCPAKC SFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRSLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LQLEQNFFNCSCDIRWMQLWQEQGEA-KLNSQNLYCINAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EISEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FILFDEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >H_sapiens_ENSP00000354207 --------------------------------------------------MDVSLCPAKC SFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRSLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LQLEQNFFNCSCDIRWMQLWQEQGEA-KLNSQNLYCINAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EISEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FILFDEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFVMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >E_caballus_ENSECAP00000010683 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWRGLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-RLNSQNLYCVGAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVH------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FVSIYE-SPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >R_norvegicus_ENSRNOP00000046935 --------------------------------------------------MDVSLCPAKC SFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRGLHTLN-----AVDMELYTGLQ KL--TIKNSGLRNIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-RLDSQSLYCISAD------------------- ------------------------------------------------------------ -------GSQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLVEPEV-- -RLE-HCIEFVVRGNPTPTLH-WLYNGQPLRESKIIHMD-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNALGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDF---------------------------------- -------------FDFESDASPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYREGPYQKGPFSVSWQQQRLAASAASTL-FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_domestica_ENSMODP00000035175 MLSWK--------------------------------------------------KCHGP GMARLLGFCWLVLVFWRGSQACPTSCSCSTTRIWCSNPSPGIMAFPRLESNSPD------ -------PENITEI------------------YIAKQPKLESIT-----EDDLEGYVGLK NL--TVVESGLRMVAHQAFLKNPNLQYI-------NFTKNK-LTSLSRKHFRHLFLSE-- -LTLVGNPLKCSCDILWVKTFQEIKSS--SETQDLYCTNEN------------------- ------------------------------------------------------------ -------NQKIALRDLKIP----NC---VV--PSANL-IT-PNLTVEEGKS-I------- -----------------------------------------------------TLFCNTS GHPAPDVS-------WDVGN-----LVS--KHMN-------ETN-----KASASLKITNI SSDDSG---KQISCVAENIVGEA-QDTVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPTLQ-WFYQGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGVYTLMAKNEYGKDDKWVQAH---------------------------- ------------------------------------------------------------ ------------FMGR-PGI-DDGEY---------------------------------- -------MT-PLFLIVDYETTSNDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNQITS---TDVSNRE---------- ---NED-------SITVYVV----VGIAALVCTGLVIMLIIL-KFGR---------HSKF GMKGESL-----------F--------LTLGPSSVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQEKILVAVKT---------LK-DASENARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKYL-RAHGP-DAVLM------A EGN----RP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKDIHSLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_musculus_ENSMUSP00000078757 MSPWL--------------------------------------------------KWHGP AMARLWGLCLLVLGFWRASLACPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVD------ -------PENITEI------------------LIANQKRLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAYKAFLKNSNLRHI-------NFTRNK-LTSLSRRHFRHLDLSD-- -LILTGNPFTCSCDIMWLKTLQETKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNMPLANLQIP----NC---GL--PSARL-AA-PNLTVEEGKS-V------- -----------------------------------------------------TLSCSVG GDPLPTLY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVRGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLMAKNEYGKDERQISAH---------------------------- ------------------------------------------------------------ ------------FMGR-PGV-DYETN---------------------------------- -------PNYPEVLYEDW-TTPTDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNKSNEIPS---TDVADQS---------- ---NRE-------HLSVYAV----VVIASVVGFCLLVMLLLL-KLAR---------HSKF GMK---------------------------GPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHTRKNIKSIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_domestica_ENSMODP00000035165 --------------------------------------------------MDVSLCPTKC SFWRIFLLGSFWLDYLGSVLACPANCVCSKTEINCKNPD-DGNLFPLLEGQDSGNSNGNA SINITDISRNITSI------------------HIENWRSLHTLN-----AVDMELYTGLQ KL--TIKNSGLRNIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLEQNFFNCSCDIRWMQLWQEQGEA-KLNSQNLFCISTD------------------- ------------------------------------------------------------ -------GSRIPLQRMNIT----QC---DL--PEISV-SH-INLTVREGEN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WTVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVMSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIRVE-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNQLGTANQTIKGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-EKRSI---------------------------------- -------------FEIFYEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYREGPSRKGQFSTTWQRQRLAAPAATTVNWKPPENSLLPG IE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-IMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >R_norvegicus_ENSRNOP00000045635 MSPWP--------------------------------------------------RWHGP AMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSID------ -------PENITEI------------------LIANQKRLEIIN-----EDDVEAYVGLK NL--TIVDSGLKFVAYKAFLKNGNLRHI-------NFTRNK-LTSLSRRHFRHLDLSD-- -LILTGNPFTCSCDIMWLKTLQETKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNTPLANLQIP----NC---GL--PSARL-AA-PNLTVEEGKS-V------- -----------------------------------------------------TISCSVG GDPLPTLY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVRGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLMAKNEYGKDERQISAH---------------------------- ------------------------------------------------------------ ------------FMGR-PGV-DYETN---------------------------------- -------PNYPEVLYEDW-TTPTDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNKSNEIPS---TDVADQT---------- ---NRE-------HLSVYAV----VVIASVVGFCLLVMLLLL-KLAR---------HSKF GMK---------------------------GPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHTRKNIKNIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_nigroviridis_ENSTNIP00000013205 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------L--PVVNI-VA-SQSKIQERGN-L------- -----------------------------------------------------TFVCQVT GSPTPTVR-------WQTEE-----LSS--KYFI-------QQEVIWSSTLELVLHLTNV SSHDNL---HNLTCEAENQAGPG-EDMVQLDIE------------FPVKIIFLKNAVQ-- -HHH-WCFPFAVDGNPEPTIS-WLYNGKELKKSEFMYTQ-----FMPDS--GDGSVKHGC LNLNKPTHLNNGNYTLIVQNKLGRDEATAFGD---------------------------- ------------------------------------------------------------ ------------FMIN-PFD-FICMN---------------------------------- ------------FLLIEYFSSS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------FHKQVSHGR---------- ---DGE-------PKKVFVA----VGLALFACTFLLVMILIINKCGQ---------HPKF GLH---------------------------IGSSVLSAEDDLAVSLRFLK---FGTS--P PSSEEDS---------------------GLSS---------------------------- --------------------------------FVEN-PQYFCGI---------------- ------IKEKDMCVQHIKRQDIVLKWELGEGAFGKVYLA-ECANLS-------------- PDSDRMLVAIKT---------LK-DANESTRQDFQREAELLT-----VLQHQHIVRFY-- ---------------GVCTDGELLAMVFEY-MRHGDLNRFLSRAHGP-DAHIL------E ESKM-A-AL---------GQLTLPQMLHIAAQIASGMVYLASLHFVHRDLATRNCLVGEH LVVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGRTMLPIRWMPPESIMYRKFTTESDIWSFGVVLWEIFTYGK-QPWYQLSNT E----------------------------------------------------------A IECI-----TQGR--ELERPRTCPNEVYV-LMQGCWQREPQQRMVIKDIHSCLLRLVKNP PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_gallus_ENSGALP00000020539 MVSWR--------------------------------------------------RRPGP SLARLWGLCCLVLGCWRGALGCPASCRCSSWRIWCSEPVPGITSFP-VPQRSTE------ -------DDNVTEI------------------YIANQRKLESIN-----DNEVGFYVGLK NL--TVVDSGLRFVSRQAFVKNINLQYI-------NLSRNK-LSSLSKKPFRHLGLSD-- -LILVDNPFKCSCEIMWIKKFQETKFY--TEAQDIYCVDDN------------------- ------------------------------------------------------------ -------NKRIALMDMKVP----NC---DL--PSANL-SN-YNITVVEGKS-I------- -----------------------------------------------------TLYCDTT GGPPPNVS-------WVLTN-----LVS--NHES-------DTS-----KNPASLTIKNV SSMDSG---LWISCVAENIVGEV-QTSAELTVF------------FAPNITFIESPTP-- -DHH-WCIPFTVKGNPKPTLQ-WFYEGAILNESEYICTK-----IHVIN----QSEYHGC LQLDNPTHLNNGAYTLLAKNEYGEDEKRVDAH---------------------------- ------------------------------------------------------------ ------------FMSV-PGD-GDG------------------------------------ -------PIVDPDVYE-YETTPNDL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNNSNQITS---PDVSNKE---------- ---NED-------SITVYVV----VGIAALVCTGLVIMLIIL-KFGR---------HSKF GMK---------------------------GPSSVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----RP---------AELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHSLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_guttata_ENSTGUP00000003194 ------------------------------------------------------------ ----------------------------XXWRIWCTGSSPGIASFP-VPQRSAE------ -------GDNVTEI------------------YIANQPNLESIN-----DNEVGFYVGLK NL--TVVDSGLRFVSRHAFVKNVNLQYI-------NLSRNK-LSSLSKKPFRHLGLSD-- -LILVDNPFKCSCEIMWIKKFQETKFY--TETQDLYCIDDN------------------- ------------------------------------------------------------ -------NKKTALLDMKVP----NC---DL--PSANL-SN-YNITVVEGKS-I------- -----------------------------------------------------TLYCDTT GGPPPNVS-------WVVTN-----LVS--NHES-------DTN-----KNPASLTIKNV SSMDSG---LEISCVAENIVGED-QASAELTVF------------FAPNITFIESPTP-- -DHH-WCIPFTVKGNPKPTLQ-WFYEGAVLNESEYICTK-----IHVIN----QSEYHGC LQLDNPTHLNNGAYTLLAKNDYGEDEKRVDAH---------------------------- ------------------------------------------------------------ ------------FMSV-PGD-GNG------------------------------------ -------PILDPDVYE-YETTPNDL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDATNNSNQITS---TDVSNKE---------- ---NED-------SITVYVV----VGIAALVCTGLVITLIIL-KFGR---------HSKF GMK---------------------------GPSSVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVHHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQGKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAGLM------A EGN----RP---------AELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHSLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >H_sapiens_ENSP00000365387 MSSWI--------------------------------------------------RWHGP AMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD------ -------PENITEI------------------FIANQKRLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAHKAFLKNSNLQHI-------NFTRNK-LTSLSRKHFRHLDLSE-- -LILVGNPFTCSCDIMWIKTLQEAKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNIPLANLQIP----NC---GL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCSVA GDPVPNMY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPS---TDVTDKT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >M_mulatta_ENSMMUP00000030437 MSSWI--------------------------------------------------RWHGP AMARLWGFCWLVVGFWRAALACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD------ -------PENITEI------------------FIANQKRLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAHKAFLKNSNLQHI-------NFTRNK-LTSLSRKHFRHLDLSE-- -LILVGNPFTCSCDIMWIKTLQEAKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNIPLANLQIP----NC---GL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCSVA GDPVPNMY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPS---TDVTDKT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_pygmaeus_ENSPPYP00000021662 MSSWI--------------------------------------------------RWHGP AMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD------ -------PENITEI------------------FIANQKRLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAHKAFLKNSNLQHI-------NFTRNK-LTSLSRKHFRHLDLSE-- -LILVGNPFTCSCDIMWIKTLQEAKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNIPLANLQIP----NC---GL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCSVA GDPVPNMY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPS---TDVTDKT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >P_troglodytes_ENSPTRP00000036008 MSSWI--------------------------------------------------RWHGP AMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD------ -------PENITEI------------------FIANQKRLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAHKAFLKNSNLQHI-------NFTRNK-LTSLSRKHFRHLDLSE-- -LILVGNPFTCSCDIMWIKTLQEAKSS--PDTQDLYCLNES------------------- ------------------------------------------------------------ -------SKNIPLANLQIP----NC---GL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCSVA GDPVPNMY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPS---TDVTDKT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >E_caballus_ENSECAP00000010149 MSSWT--------------------------------------------------RWHGP ATARLWGFCWLVMGFWRSALACPTSCKCSASRIWCSDPSPGIMAFPRLEANSAD------ -------LENITEI------------------YIANQKRLEIIN-----EDDVEAYVGLK NL--TIVDSGLKFVAHKAFLKNTNLQHI-------NFTRNK-LTSLSRKHFRHLDLSE-- -LILVGNPFTCSCDIMWIKTLQETKSS--PETQDLYCLNES------------------- ------------------------------------------------------------ -------SKNIPLANLQIP----NC---GL--PSANL-AA-PNLTVEEGKS-V------- -----------------------------------------------------TLSCSVA GDPVPNLY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYKLVAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGTN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNNIPS---TDVADNT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_rubripes_ENSTRUP00000006203 --------------------------------------------------MDLWFYSIRI YWWRVLFLMSIFQDYLSSMLDCPPTCSCSQTEIYCNKSD-NDRFFPLLALQDTG--SNGT NVDIKELFKNITSI------------------HIENWTGLQTLK-----DVDMELYTGLQ RL--TIMNCNLKVIQPRAFAQNSNLRYI-------NLSKNP-LTTLSWQLFQNLQLAE-- -LRLDGVVFECGCNIRWIQLWMQRGEA-GLHTQELYCKNE-------------------- ------------------------------------------------------------ -------DSQIRLHNMYIQ----KC---DL--PEISV-SH-GSVLVTEGDN-V------- -----------------------------------------------------TVSCNGS GLPLPDVD-------WTISG-----LRS--INTH-------MVNVNWPNTHSINXTLFNI SRDDNN---YQLTCIAENVVGMT-NASVQLNVQ------------FPPVILRLAEPEQ-- -RHD-TCIEFTVRGYPHPKLR-WFHQQKEIQQNDYIRTE-----MDFYQ-----DYLEGC LTFQTPTHINNGNYTLEASNPLGTVTKTVYGH---------------------------- ------------------------------------------------------------ ------------FLMA-PDI-DEGF----------------------------------- ------------SVVFCFAVTTAPT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DGETGRT---------- ---HED-------TFGVSIA----VGLAGFACILLLVLFVLINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHVN---HGII--T PCTLDAGPD-------------------AVVI---------GMTRIP------------- --------------------------------VVEN-PQYFRHGHN-------------- ------CNKPATLVQHIKRRDIILKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPNLSARKDFQREAELLT-----NLQHDHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPLQ-SN---------GELGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSSDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGK-QPWFQLGNN E----------------------------------------------------------V IECI-----TQGR--VLERPRICPKEVYD-IMLGCWQREPQQRLNIKDIQKVLFAMGKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >B_taurus_ENSBTAP00000053704 MSSWT--------------------------------------------------RWHGP AMARLWGFCWLIVGFWRAALACPTSCKCSASRIWCGDPSPGIVAFPKLEATSAD------ -------PENITEI------------------YIANQKRLEIIN-----EDDLEAYVGLK NL--TIVDSGLKSVAHKAFLKNSNLQHI-------NFTRNK-LTILSRKHFRHLDLSE-- -LILVGNPFTCSCDVMWIKTLQETKPS--PETQDLYCLDEN------------------- ------------------------------------------------------------ -------SKNISLANLQIP----HC---GL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCTVA GDPVPNLY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------FAPTITFLESPTS-- -DHH-WCIPFTVKGNPKPALQ-WFYNGAILNESKYICTK-----IHVTN----HTEYHGC LQLDNPTHMNNGDYKLVAKNEYGKDEKQISAH---------------------------- ------------------------------------------------------------ ------------FMGW-PGI-DDGAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNKSNGTLP---TGVVD-T---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_aculeatus_ENSGACP00000002644 ------------------------------------------------------METPGG CWTLVLLLGVLSGGYLSSVPDCPPTCACSPTDIYCNQSD-SSRFFPLLSFQGPS---GPA NSSIEDLFQNISSI------------------HIENWTGLQTLR-----EVDMELYTGLQ RL--TIVRSNLHTIQARVFSKNPHLRYI-------NLSRNPMLTTLSWQIFENLQLFE-- -IHLEEVVFNCGCGIRWLQLWQQRGEA-GLSSQQLHCADD-------------------- ------------------------------------------------------------ -------DTKILLQDMNIS----SC---DL--PEISV-SH-SNLTVVEGDQ-V------- -----------------------------------------------------TAICNGS GSPLPEVD-------WPVNG-----LHS--INAA-------RVYDNNT-IHSINITLVNV SREDNN---FLLTCTATNVVGMT-NASVQLTVH------------FPPSIVKLKEPER-- -RHD-TCIEFTVRGSPHPTLQ-WFHRDMEISHTKYVRPD-----MDIYQ-----DYIEGC LIFQNPTHHNNGNYTLTASNYLGVATSSVYGH---------------------------- ------------------------------------------------------------ ------------FIDK-PFD-GILLF---------------------------------- ------------SHRTADALSPVTP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------TAETHKP---------- ---EED-------HFGVSIA----VGLAGFACVMLVVLFLLINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHVN---HGII--S PCTLDPGSD-------------------AVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRHGHN-------------- ------CNKPATYVQHIKRRDIILKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DALIL------V DGQPLQ-TN---------GELGLSQMLHIASQIAAGMIYLASQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSTDYYRLGKEGGEDGCRVCVK----------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLANN E----------------------------------------------------------V IECI-----TQGR--VLERPRLCPKEVYD-MMLGCWQREPQQRLNVKDIQKILFTLMKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >D_rerio_ENSDARP00000086160 ------------------------------------------------------------ -----------------------ISFNCVSSICVCR------------------------ --------------------------------HIENW-SLQTLK-----DLDMELYTGLQ RL--NIVNCNLRTIQSRAFAKNPHLRYI-------NLSRNP-LTTLSWQLFQNLQLLE-- -LKLEGVVFNCSCNIRWIQLWQQRGEA-GLHNQQLFCFNG-------------------- ------------------------------------------------------------ -------YSKIPLQLMNIS----QC---DF--PEISV-SH-SNLTVTEGDR-V------- -----------------------------------------------------MITCNGS GIPVPEVD-------WTVGG-----LHS--INTH-------QANQYPPNVHSINLTLVNV SRDDNG---FMLTCIAENIVGMT-NASIQLSVQ------------FPPAIINFEEPQK-- -RHD-TCMMFTVRANPLPTLH-WSFKGEEIKATEYVHPE-----MEVYQ-----DNLEGC LLFKNPTQHNNGNYTLEARNYLGVAVKTVYAH---------------------------- ------------------------------------------------------------ ------------FLHP-PFE-GTCAF---------------------------------- ---------------VCFLVSPTPT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AIPTMTHRP---------- ---EED-------TFGVSIA----VGLAGFACVLLVVMFVLINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHVN---HGII--T PCTLDAGPD-------------------AVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRHGHN-------------- ------CNKPATYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPLQ-TN---------GELGLSQMLHIASQIASGMVYLGSQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSTDYYRVREVTNNDV---------------------------LV SQ-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLANN E----------------------------------------------------------V IECI-----TQGR--VLERPRLCPKEVYD-IMLGCWQREPQQRLNIKDIQKILFALGKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_aculeatus_ENSGACP00000019520 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWTGLQTLR-----DVDMELYTGLQ RL--TIMNCNLRAIQARVFAQNPHLRYI-------NLSKNP-LGTLSWQLFQHLQLSE-- -LRLDGVVFDCGCDIRWIQLWQQRGEA-GLHTQQLYCRNG-------------------- ------------------------------------------------------------ -------ASKIRLHNMYIH----NC--SDL--PEISV-SH-SSVLVMEGDN-V------- -----------------------------------------------------TVSCNGS GSPLPEVD-------WTVAG-----LNS--INTH-------LSNVYWPNVHSINLTLFNI SRDDNN---FQLTCIAENVVGMT-NSSIQLNVQ------------FPPIILRLAEPEQ-- -RHD-TCIEFTVRGYPHPKLR-WFYKQKEILQNNYIRTE-----MDFYQ-----DYLEGC LTFQNPTHINNGNYTLEASNPLGTVAKTVYGH---------------------------- ------------------------------------------------------------ ------------FLVA-PDM-EATDA---------------------------------- -----------CSACFCVSVTSTPS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DGDVGRP---------- ---DED-------TFGVSIA----VGLAGFACVLLLVIFVLINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHVN---HGII--T PCTLDAGPD-------------------AVVI---------GMTRIP------------- --------------------------------VVEN-PQYFRHGHN-------------- ------CNKPTTLVQHIKRRDIILKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPNLSARKDFQREAELLT-----NLQHDHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPLQ-SN---------GELGLSQMLHIATQIASGMVYLGSQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSSDYYRVRPWQLGQFGPCWGQRQQSKTSLSAQ-FNARGTELCIS RI-----VGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGK-QPWFQLGNN E----------------------------------------------------------V IECI-----TQGR--VLDRPRICPKEVYD-IMLGCWQREPQQRLNIKDIQKVLFAMGKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_latipes_ENSORLP00000005833 MDS----------------------------------------------------SAGEH GMARSGLFLLLTGLMWRFGGACPESCTCSISRIVCIDSEPGIEDFPVLTLD--D------ -------MENITEI------------------YIANQNRLFDLS-----DSSLRHYINLR NL--TVTRTRLTSISSDAFFNNTRLQYV-------NLRDNN-LSTLSWRTFQNFNITFP- -LLLSGNPLDCVCENLWIKLKLQEE----ADSPDLTCTDDR------------------- ------------------------------------------------------------ -------GVTRDFATLTPP----DC---VV--PTVEV-TP-QNVTEMEGGN-V------- -----------------------------------------------------KAVCSAS GSPAPVIL-------WNLDM-----LST--HYEI-------DPL-----DTESILTLTGL SSDDNG---RKIVCSVENMVGQS-EATLELNIL------------FPPAILQLLPPER-- -NHH-WCIPFTVTGNPKPELR-WYHNNTTLEEQDFIRTI-----IHEYT----ENEDHGC LQLVNPTHIHNGKYRLVVKNEFGQDEKTVSAQ---------------------------- ------------------------------------------------------------ ------------FIDP-PYF-NTTGR---------------------------------- -------LTVPSWLLLHHIPRPWYV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SKPTQSPN-------IPSQFPY---------- ---HEK-------KLKVYVV----VGIAGVALTGCVLMVIIL-KYGR---------NSKF GIK--------------------------AGSSSVISNDDDSASPLHHVS---NGNN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRNSGS-------------- ------MLKSDTFVKHIKRHNIVLKRELGEGAFGKVFLA-ECYNLV-------------- PHQEKIHVAVKT---------LK-EASESGRADFYREAELLT-----NLQHDHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RSHGP-DAVLM------A DGQH-S-IL---------VELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYK-------------------------------------- -------VGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPYMRLNIKEIYSMLQSLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_aculeatus_ENSGACP00000010114 MSAWRPG----------------------------------SGALSSPGGRSGSWRC-WW WWVLFIGVSVGSGDPWMSAEACPSSCSCSSTRISCVDPERGINAFPVLQSE-AE------ -------MENITDI------------------YIANQGSFSSIN-----DKDLHYYKNLR NL--TVTNSRLTYVSKLAFQNNIKIQYL-------NLKDNN-LSSLSWRIFKHLNMSY-- -LILTGNPLHCSCENMWIKLWLGEE----ADTQELHCIEDG------------------- ------------------------------------------------------------ -------VGRKLLSRLTLP----NC---EV--PMATL-SP-SKVRLMEGKH-V------- -----------------------------------------------------DLSCETS GVPSPELI-------WNMA------LVS--NYEI-------ETS-----GQLSVLRLSNL SSMDHN---SKISCTAENIVGDK-ESSLLLDIL------------FPPKILKLSDAIN-- -DHH-WCIPFSITGNPKPKLQ-WFLDDKAVTEGPFIETK-----IHDIT----DREYHGC LQLDSPTHLNNGRYRLLIKNEYGSDEKEVEAH---------------------------- ------------------------------------------------------------ ------------FMRK-PWD-GAGTD---------------------------------- -------KEPY---YYAIVKVLNPT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------NPVTNNCVFIVSLFSDISSHHF---------- ---HPH-------QLTVYVV----VGIAAVAFTGFLLMLVIL-KFGG---------NSKF GIK---------------------------GSSSVISNDDDSASPLHHVS---NGSN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRSTNS-------------- ------LLKTDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLS-------------- PDQEKILVAVKT---------LK-EASENARKDFHREAELLT-----NLQHEHIVTFY-- ---------------GVCVDSDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGQT-T-RP---------VELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHCLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_latipes_ENSORLP00000006595 MSAYQPG----------------------------------SWALSG----SESWRCLLW WWFLSWGLAVGSGDPWMSAEACRSSCSCSSTRISCVDPETGISSFPSLQSD-AE------ -------MENITDI------------------YIANQSGFSSIN-----DKDLHRYKNLR NL--TVTNSRLTYVTKLAFQNNLKLQYL-------NLKDNN-LSSLSWRIFKHLNISY-- -LILSGNPLRCSCENMWIKLLLGEE----ADIQELRCTEDG------------------- ------------------------------------------------------------ -------GARKLLSRLTLP----NC---EV--PMATL-SP-SKTSVKEGEN-L------- -----------------------------------------------------ELSCTTS GVPAPELN-------WSMA------LAT--NYEI-------ETS-----GQISVLRLSNL SSLDHN---SKISCIAENIVGEK-ESSLQLDIL------------FPPKITKLSDAIP-- -DHH-WCIPFSVAGNPVPHFQ-WYLNENEVTEGAYIMTM-----IHDIT----EREYHGC LQLDNPTHLNNGRYRLVVTNEYGMDQKEVDAH---------------------------- ------------------------------------------------------------ ------------FMRQ-PWE-ELGPD---------------------------------- -------TAYYVLLYFDFGFIINYY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------HNFTN--ILSHSPTVNPPEDRV---------- ---AVS-------HLSVYVV----VGIAAVAFTGFLLMLVIL-KFGG---------NSKF GIKVFSF--------YFCFSFANMKDRKGQSPSSVISNDDDSASPLHHVS---NGSN--T PSSSEMGAD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRSTNS-------------- ------LLKTDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLS-------------- PDQEKILVAVKT---------LK-EASENARKDFHREAELLT-----NLQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGQT-T-RP---------VELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHGLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_rubripes_ENSTRUP00000024299 -----------------------------------------------------HMCKCSE WRIFLGCVWKDDKGSKKRTETCPLSCSCSSTRISCVDPEWDINAIPILSE--AE------ -------MENITDIQPSPCLEVTDTSQQTSSRYIVNQISLSSIN-----DKDLYYYKNLR NL--TVINSRLTYVSKLAFENNIKLQYL-------NLKDNN-LSTLSWRIFHHLNISY-- -LFLSGNPLHCSCENMWIKLWLGEE----ADAQELRCIEDG------------------- ------------------------------------------------------------ -------GGRKLLSRLTLP----NC---EV--PMATL-SP-SRVTLKEGEN-L------- -----------------------------------------------------DLSCTTS GEPAPDLI-------WSMA------LLS--SYEVCTHACTHNTN-----THTDWLRLSNL SSLDHN---SKISCTAENIVGEK-GSSLLLDIL------------FPPKITKLSDAIS-- -DHH-WCIPFSVSGNPKPELQ-WLQNDRPVTEGAYIMTL-----IHDIT----DREYHGC LQLDNPTHLNNGNYTLIAKNKFGMDQKAIDAH---------------------------- ------------------------------------------------------------ ------------FMLE-PWV-RASLS---------------------------------- ------------YFLFSEVDEEPPT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MDP---------- ---PED-------GFALYVV----VGIAAVAFTGFLLMLVIL-KFGG---------NSKF GIK---------------------------GPSSVISNDDDSASPLHHVS---NGSN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRSTNS-------------- ------LLKTDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLS-------------- PDQEKILVAVKT---------LK-EASENARKDFQREAELLT-----NLQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------T EGQT-T-RP---------VELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYRYSRESPVRVCVWVD------------------------ -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHGLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_gallus_ENSGALP00000010970 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TIRNSGLRNIQPRAFAKNPHLRYI-------DLSGNR-LTTLSWQLFQTLRLFD-- -LRLERNPFNCSCDIRWIQLWQEKGEA-NLQSQQLHCMNLD------------------- ------------------------------------------------------------ -------TAVILLRNMNIT----QC---DL--PEISV-SH-VNLTVREGEN-A------- -----------------------------------------------------VITCNGS GSPLPDVE-------WTVAD-----VHS--INTH-------QVGPRGCSAAGITAILCGL GNSRLN---FLAGCTFNN-LNFP-SAQGMMQLL------------DPPRILTLEEPVL-- -HLE-HCIAFAVHGNPAPTLH-WLHNGQVLRETEIIHME-----FYQQG-----EVSEGC LLFNKPTHYNNGNYTIVATNQLGSANQTIKGH---------------------------- ------------------------------------------------------------ ------------FLEK-PFP-GRMFT---------------------------------- -----------LVRVGDYEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTNDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYREGPRPKGQLSTAWQRHRLAPPAAAT------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-IMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_aculeatus_ENSGACP00000021397 ------------------------------------------------------------ GMARVGLFLVLMGL-WRFGDACPASCTCSISRIVCNDSVPGIEDFPVLTLD--D------ -------MENITEI------------------YITNQNRLFDIN-----DNSLRHYINLR NL--TVMKTRLTSLSSDAFFNNTRLQYV-------NLRDNN-LSTLSWRTFQSFNATYP- -LLLSGNPLDCVCENIWIKLRLLEE----TDSPDLTCIDDR------------------- ------------------------------------------------------------ -------GAPKAFASLSPP----DC---VV--PKVEV-TP-KSVTMMQGSN-V------- -----------------------------------------------------KAVCSAS GSPPPEIL-------WNLDW-----LST--HHEI-------DPS-----EMESSITLTDL SPDDNG---KVIICSAENMVGQT-EATLQLNIL------------FAPTIQQLLGPER-- -DHH-WCIPFSVTGNPKPELQ-WYHENVALLEQDFMRTR-----IHLST----ESEDHGC LQLVNPTHIHNGVYRLVAKNEYGRDEKKVSAQ---------------------------- ------------------------------------------------------------ ------------FIDP-PYI-NHTAF---------------------------------- ----------------QQKKTSTNV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SDDSENSNRAHR---RDNNRMC---------- ---GVF-------SLQVYVV----VGIAGIALTGCVLMVIIL-KYGR---------NSKF GLK------------------------GSLGSSSVISNDDDSASPLHHVS---NGNN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRNSGG-------------- ------MLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLT-------------- PDQEKLHVAVKT---------LK-EANESGRADFYREAELLT-----NLQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RSHGP-DAVLM------A DGQH-C-IQ---------VELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPYMRLNIKEIHSMLQSLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >D_rerio_ENSDARP00000009843 AVSPFRGDQIRPLHDSLASRTTSLRIPQQRRLISELLKILQDTTQRRTHRARPAMTAGVR GMACWGLCGFLFGL-LRISSACPVSCFCNASRISCIDQEPGIEDFPVLMPE-SD------ -------MENITDI------------------YISNQKRLFTIN-----EDHMKFYSNLR NL--TVTNTHLTYVSTMAFFNNSKLQYL-------NLRDNN-LSTLSWMAMRNSNSVWVC IRLLSGNPLQCACENIWIKLWLDD-----SERDVLQCLQEG------------------- ------------------------------------------------------------ -------GKAKTLSRLTLP----LC---EH--PRVEV-FP-TDVSQMAGSD-A------- -----------------------------------------------------TVICNAS GSPTPELT-------WTLNSSEHPPLST--SHEI-------SKM-----DLQSVLTLNGL SPNDNG---RKLICSAENIVGQI-EATVMLNIS------------FPPTVLELYLPER-- -SQD-WCIPFVVTGNPRPDLH-WYHEGKPLEEQEYIRTE-----IHDIT----NTEYHGC LKLDTPTHIHNGIYTLVASNEFGEDRGNVTAH---------------------------- ------------------------------------------------------------ ------------FMRI-PDV-DHSGI---------------------------------- ------------EGVFYYDTTVSPD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IPP---------- ---LED-------RVAVYIV----VGIAGVALTGCILMLVFL-KYGR---------SSKF GMK---------------------------GSSSVISNDDDSASPLHHVS---NGNN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRNPGS-------------- ------MLKSDTLVQHIKRHNILLKRELGEGAFGKVFLA-ECYNLS-------------- PDQEKILVAVKT---------LK-EASESGRADFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A DGQQ-S-LL---------VELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPYMRLNIKEIHNLLQSLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_latipes_ENSORLP00000018307 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWTGLETLR-----DVDMELYTGLQ RL--TIMNCRLKVIQPRAFAQNPHLRYI-------NLSKNP-LTTLSWQLFKHLQLSE-- -LRLDGVVFDCGCDIRWIQLWQQRGEA-MLHTQELYCRDG-------------------- ------------------------------------------------------------ -------ASKIRLGNMQVC----VCVLPDL--PEISV-SH-SSVLVREGDN-V------- -----------------------------------------------------TVSCNGT GLPLPEVD-------WTVGQ-----LNS--INTH-------MSNVYWPNIHSIDLNLFNI SRDDNN---FQLSCIAESVVGMT-NSSIQLNVQ------------FPPVIIALAEPQQ-- -RLD-TCIEFTVRGNPHPKLR-WFHKHEEIQQNKYIRTD-----MDFYQ-----DTLEGC LIFRNPTHLNNGNYTLEATNPLGRATKTVYGH---------------------------- ------------------------------------------------------------ ------------FLVA-PDD-SGE------------------------------------ ------------KTLLFFKISGLPS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DGVSGQQ---------- ---DED-------TFGVTIA----VGLAGFACILLLVLFVLINKYGR---------RSKF GMK---------------------------GKFIRIA-RQKAVRXXXXXN---HGII--T PCTLDAGPD-------------------AVVI---------GMTRIP------------- --------------------------------VVEN-PQYFRHGHN-------------- ------CNKPTTLVQHIKRRDIILKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPNLSARKDFQREAELLT-----NLQHDHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DSMIL------V DGQPLQ-SN---------GELGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSSDYYRLFLSSNRKMFLFLSQ----------------------- -------VGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGK-QPWFQLGNN E----------------------------------------------------------V IECI-----TQGR--VLERPRICPKEVYD-IMLGCWQREPQQRLNIKDIQKVLFAMGKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_nigroviridis_ENSTNIP00000010362 MDS----------------------------------------------------GAGGY GMARLGLFVVLAGL-WRFADACPASCTCSTSRIVCVDPAPGIDDFPVLTLD--D------ -------MENITEI------------------FISNQNRLFDIT-----DSSLRHYINLR NL--TVMKTRLTSISPDAFYNNTRLQYI-------NFRDNN-LSTLSWRTFQNFNSSFPK RLLLSGNPLECICENYWIKSRLLEE----PDGQDLTCTDDR------------------- ------------------------------------------------------------ -------GASQAFITLTPP----DC---VV--PDVVV-SP-NTVTEMQGRS-I------- -----------------------------------------------------NAVCKAT GSPPPEIQ-------WNLDM-----VST--QFKV-------IPA-----DMETSLVLSDL SPDDNG---RVIVCSAENVVGKN-EATLQLDIH------------FAPSVKELLEPER-- -DHH-WCIPFSVKGNPKPDLQ-WYHESMPLQEQDYIRTR-----IHEST----ESEYHGC LQLVNPTHIHNGMYKLVATNTYGQDEKTVSAQ---------------------------- ------------------------------------------------------------ ------------FIEP-PNF-NHTGN---------------------------------- -------ANMGSVFLFYFQQKTLST----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TLLTAAFSF------ADSPLPP---------- ---LDD-------SVAVYVV----VGIAGVALTGCVLMVIIL-KYGR---------NSKF GMK---------------------------GSSSVISNDDDSASPLHHVS---NGNN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRNSIS-------------- ------MLKSDTFVQHIKRHNIILKRELGEGAFGKVFLA-ECYNLT-------------- PDQEKIHVAVKT---------LK-EANESSRADFYREAELLT-----N-QHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RSHGP-DAVLI------V DGQH-S-IP---------VELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWHREPYMRLNIKEIYGMLQGLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_rubripes_ENSTRUP00000001471 MDS----------------------------------------------------GAGGY GMARLGLFVVLAGL-WRFADACPASCTCSISRIVCVDPAPGIEDFPVLTLD--D------ -------MENITEI------------------FISNQNRLFDIT-----DSSLRHYINLR NL--TVMKTRLTSISPDAFYNNTRLQYV-------NLRNNN-LSTLSWRTFQNFNSSYP- -LLLSGNPLVCICENLWIKLRLLEE----PDGQDLTCTDDR------------------- ------------------------------------------------------------ -------GVSQAFITLTPP----DC---VV--PKVVV-SP-NMVTEMQGSD-V------- -----------------------------------------------------KAVCQAT GSPPPEIQ-------WNLDM-----IVT--HKEI-------EPL-----EVGIGLTLSDL SPDDNG---RVIVCSAENMVGQN-EATLQLDIH------------FAPSVQQLLEPER-- -DHH-WCIPFSVKGNPKPDLQ-WYHENLPLQEQDYIRTR-----IHEST----ESEYHGC LQLVNPTHIHNGVYRLVAKNQYGQDEKTVSAQ---------------------------- ------------------------------------------------------------ ------------FIEP-PNF-NHTGL----------------------------GAFSSF SAALFGNANMRSFFLFYFQQKIL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------STTVYVV----VGIAGIALTGCVLMVIIL-KYGR---------NSKF GIK---------------------------GSSSVISNDDDSASPLHHVS---NGNN--T PSSSEMGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRNSIS-------------- ------MLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLT-------------- PDQEKLHVAVKVGVRMLFPGPVL-QRSDPERSQREQPCGLLQGGRAPHQQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RSHGP-DALLI------V DGQH-S-IP---------VELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWHREPYMRLNIKEIYGMLQSLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_nigroviridis_ENSTNIP00000018873 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LSFS----NV---EV--PMATL-SP-SRVTLKEGEN-V------- -----------------------------------------------------DLSCTTS GAPAPDLI-------WRHAQ------VA--NYEI-------LTS-----GQVSVLRLSNL SSLDHN---SKISCTAENIVGEK-ESSLLLDIL------------FPPKIIKLSDAIP-- -DHH-WCIPFSVSGNPKPELE-WLLDDERVIEGPYIMTR-----IHDVT----DREYHGC LQLDSPTHLNNGHYTLIAKNKFGTDHKSVEAH---------------------------- ------------------------------------------------------------ ------------FMLK-PWS-GTDKE---------------------------------- -------PYYYLELRILRGSETNTI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------WDDCVRVSELVPSA------------------- ---SFL-------LVQLYVV----VGIAAVAFTGFLLMLVIL-KFGG---------NSKF GIKGIIYEAVKEAVVNLVLVFSLSPGTCTSGPSSVISNDDDSASPLHHVS---NGSN--T PSSSEIGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRSTNS-------------- ------LLKTDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLS-------------- PDQEKILVAVKT---------LK-EASENARKDFQREAELLT-----NLQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------T EGQT-T-RP---------VELTQSQMLHIAQQIASGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYRLQECSFAESGRNDGAEEMAAGKETGEKRERTDEEILNS PAAMPGLVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHGLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_latipes_ENSORLP00000023354 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TKSLFFS------------VPPSVVNLMKPER-- -RHD-TCIEFTVRGFPHPTLK-WFHNNQEIYHTEYVRPD-----METYL-----DYIEGC LNFKNPTHHNNGNYTLMATNELGVANRTVYGF---------------------------- ------------------------------------------------------------ ------------FMEV-PLS---------------------------------------- ----------------IDIVSPVPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ISETKEP---------- ---QED-------SMRVSVA----VGVAGFACAVLTVFFLLI-KYRR---------RSKL TMK---------------------------GPTAGMSG-EDSASPFHHIN---HGVV--S PCMVDLSSD-------------------AVAI---------GMNRIP------------- --------------------------------VIEN-PQYFKHGHN-------------- ------CSKPTTYVQHIKQRDIILKRELGEGAFGKVFLA-ECYNL--------------- -TKDKMLVAVKT---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DDESLQ-TK---------GELGVSQMLHIGSQIASGMIYLASQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFHLSNN E----------------------------------------------------------V IECI-----TQGR--VLERPRLCPKEIYD-MMLGCWQREPQQRLNIKDIQKTLFSLMKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_guttata_ENSTGUP00000008634 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DLSGNR-LTTLSWQLFQTLRLFE-- -LRLERNLFNCSCDIRWIQLWQEKSEA-NLQYQDLYCMTMD------------------- ------------------------------------------------------------ -------AAIITLKEMNIT----QC---DL--PEISV-SH-VNLTVREGEN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WTVAE-----LHS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FLLTCIAENVVGMS-NASVLLTVY------------YPPRILTLEEPVL-- -HMD-HCIAFAVHGNPAPTLH-WLHNGQVLRETEIIRME-----FYQQG-----EVSEGC LLFNKPTHYNNGNYTIVATNQLGSANQTIKGH---------------------------- ------------------------------------------------------------ ------------FLEK-PFP-GRI------------------------------------ -------------FIGDYEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFIMINKYGR---------RSKF GMK---------------------------GPVAVISGEEDSASPLHHIN---HGIT--T PSSLDAGPD-------------------TVVI---------GMTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTNDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------V---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_gorilla_ENSGGOP00000009979 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWRSLHTLN-----AVDMELYTGLQ KL--TIKNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -XXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX------------------- ------------------------------------------------------------ -------XXXXXXXXXXXX----XX---XL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALTVY------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVE-----YYQEG-----EISEGC LLFNKPTHYNNGNYTLIAKXPLGTANQTINGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-ESTDN---------------------------------- -------------FILFDEVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITXXXXX---------- ---XXX-------XXXVSIA----VGLAAFACVLLVVLFVMINKYGR---------RSKF GMK---------------------------XXXXXXXXXXXXXXXXXXXX---XXXX--X XXXXXXXXX-------------------XXXX---------XXXXXX------------- --------------------------------XXXX-XXXXXXXXX-------------- ------XXXXXXXVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKX---------XX-XXXXXXXXXXXXXXXXXX-----XXXXXXXXXXX-- ---------------XXXXXXXXXXXXXXX-XXXXXXXXXX-XAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQXASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRL--------------------------FNPSGNDFCIW CE-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT E----------------------------------------------------------V IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >D_rerio_ENSDARP00000078225 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GPSSVISNDDDSASPLHHVS---NGSN--T PSSSDMNAD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFRSTSS-------------- ------LLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLS-------------- ADQEKILVAVKT---------LK-EASENARKDFHREAELLT-----NLQHEHIVTFY-- ---------------GVCVESDPLIMVFEY-MMHGDLNKFL-RAHGP-DAVLM------S DGQI-Q-QQ---------AELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHTRLNIKEIHNLLLNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >X_tropicalis_ENSXETP00000025668 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TVVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLY-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----RP---------AELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHSLLQNLSKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >C_familiaris_ENSCAFP00000001973 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TVVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >A_carolinensis_ENSACAP00000000858 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHDHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----LL---------AELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPKEVYD-LMLGCWQREPHMRLNIKEIHSLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >O_cuniculus_ENSOCUP00000008390 MSLWT--------------------------------------------------RWHGP TMARLWSFCWLALGLWRPAVACPASCTCSASRIWCSDPVPGLMAFPRLEPNSAD------ -------PENITEX------------------XXXXXXXXXXXX-----XXD--AYV-LR NL--TV-DSGLKFVAYKAFLKNSNLQHX-------XXXXXX-XXXXXXXXXXXXXXXX-- -XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX------------------- ------------------------------------------------------------ -------XXXXXXXXXXXX----XX---XL--PSASL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCNVA GDPVPNLY-------WDVGN-----LVS--KHMN-------ETS-----HTQGFLRITNI SSDDSG---KQISCVAENLVGED-QDSVNLTVH------------XXXXXXXXXXXXX-- -XXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-----XXXXX----XXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------------- ------------------------------------------------------------ ------------XXXX-XXX-XXXPN---------------------------------- -------LNYPDVIYADYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPP---TGAADNA---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVXXXXXXXXXXXXXXXXXXXX---XXXX--X XXXXXXXXX-------------------XXXX---------XXXXXX------------- --------------------------------XXXX-XXXXXXXXX-------------- ------XXXXXXXVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAVLM------A EGT----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------XXXXTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF-YGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKSIKDIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >B_taurus_ENSBTAP00000014892 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MTRIP------------- --------------------------------VIEN-PQYFRQGHN-------------- ------CHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKA---------LK-DPTLAARKDFQREAELLT-----NLQHEHIVKFY-- ---------------GVCGDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPRQ-AK---------GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGAN LLVKIG-DFGMSRDVYSTDYYRR-----------------------------MVINVW-S PL-----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPWFQLSNT EVRKGADAGRSDGVGLDIGLEDGLPTSPAPPPAPSYLVYSTHPSKLAIWRGGDIPVLLIV IECI-----TQGR--VLERPRVCPKEVYD-VMLGCWQREPQQRLNIKEIYKILHALGKAT PIYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >T_nigroviridis_ENSTNIP00000014870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LS---------------------------GPVAVISGEEDSASPLHHVN---HGII--T PCTLDAGPD-------------------AVVI---------GMTRIP------------- --------------------------------VVEN-PQYFRHGHN-------------- ------CNKPATLVQHIKRRDIILKRELGEGAFGKVFLA-ECYNLS-------------- PTKDKMLVAVKT---------LK-DPNLSARKDFQREAELLT-----NLQHDHIVKFY-- ---------------GVCVDGDPLIMVFEY-MKHGDLNKFL-RAHGP-DAMIL------V DGQPLQ-SN---------GELGLSQMLHIATQIASGMVYLASQHFVHRDLATRNCLVGNG LLVKIG-DFGMSRDIYSSDYYRVGVW---------------------------------A PY-----VGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVILWEIFTYGK-QPWFQLGNN EVRKEADGER---VPAAADPHPELPHIPAADPSPIRLTPPIRPSGLLLWEHGARPSL--V IECI-----TQGR--VLERPRICPKEVYD-IMLGCWQREPQQRLNIKDIQKVLFAMGKAT PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >G_gorilla_ENSGGOP00000013959 MSSWI--------------------------------------------------RXHGP AMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD------ -------PENITEI------------------FIANQKXLEIIN-----EDDVEAYVGLR NL--TIVDSGLKFVAHKAFLKNSNLQHX-------XXXXXX-XXXXXXXXXXXXXXXX-- -XXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX------------------- ------------------------------------------------------------ -------XXXXXXXXXXXX----XX---XL--PSANL-AA-PNLTVEEGKS-I------- -----------------------------------------------------TLSCSVA GDPVPNMY-------WDVGN-----LVS--KHMN-------ETS-----HTQGSLRITNX XXXXXX---XXXXXXXXXXXXXX-XXXXXXXXX------------XXXXXXXXXXXXX-- -XXX-XXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXX-----XXXXX----XXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------------------- ------------------------------------------------------------ ------------XXXX-XXX-XXXAN---------------------------------- -------PNYPDVIYEDYGTAANDI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GDTTNRSNEIPS---TDVTDKT---------- ---GRE-------HLSVYAV----VVIASVVGFCLLVMLFLL-KLAR---------HSKF GMKDFSW-----------FGFGKVKSRQGVGPASVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLA-ECYNLC-------------- PEQDKILVAVKT---------LK-DASDNARKDFHREAELLT-----NLQHEHIVKFY-- ---------------GVCVEGDPLIMVFXY-MKHGDLNKFL-RAHGP-DAVLM------A EGN----PP---------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN LLVKIG-DFGMSRDVYSTDYYR-------------------------------------- -------XXXXXXXXXXXXXXXXXXXXXXXXXXDVWSLGVVLWEIFTYGK-QPWYQLSNN E----------------------------------------------------------V IECI-----TQGR--VLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLLQNLAKAS PVYLDIL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >H_sapiens_ENSP00000363571 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SPLR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKVVKLEVE------------VFARILRAPESHNVT FGSF-VTLHCTATGIPVPTIT-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATISIAE--------------------- ------------------------------------MLFISSFSKPQKDNKGYCAQYRGE VCNAVLAKDALVFLNT-SYA--DPEEAQELLVHTA---------WNELKVVS-PV----- -----CRPAAEALLCN---HIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SPG-------------VVPTPIPI-CREYCLAV KELFCAKEWLV------------------------------------------------- ----------------------------------ME--EKTHRGLYRSEMH----LLS-- -VPECSKLPSMH--WDPTACARLPHLD-YNKENLKTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPN LPSSSSSSFSVSPTYSMTVI---ISIMSSFAIFVLLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HTVCS------L SHSDLS-MRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPVELYN-LMRLCWSKLPADRPSFTSIHRILERMCERA EGTVSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >P_pygmaeus_ENSPPYP00000021837 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SPLR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKVVKLEVE------------VFARILRAPESHNVT FGSF-VTLYCTATGIPVPTIT-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFTTAKAAATISIAE--------------------- ------------------------------------MLFISSFSKPQKDNKGYCTQYRGE VCNAVLAKDALVFLNT-SYA--DPEEAQELLVHTA---------WNELKVVS-PV----- -----CRPAAEALLCN---HIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SPG-------------VVPTPIPI-CREYCLAV KELFCAKEWLA------------------------------------------------- ----------------------------------ME--EKTHRGLYRSEMH----LLS-- -MPECSKLPSMH--WDPTACARLPHLD-YNKENLKTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPN LPSSSSSSFSVSPTYSMTVI---ISIMSSFAIFVLLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HTVCS------L SHSDLS-MRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPVELYN-LMRLCWSKLPADRPSFTSIHRILERMCERA EGIVSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >P_troglodytes_ENSPTRP00000049076 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SPLR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKVVKLEVE------------VFARILRAPESHNVT FGSF-VTLHCTATGIPVPTIT-WIENGNAVSSGSIEESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATISIAE--------------------- ------------------------------------MLFISSFSKPQKDNKGYCAQYRGE VCNAVLAKDALVFLNT-SYA--DPEEAQELLVHTA---------WNELKVVS-PV----- -----CRPAAEALLCN---HIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SPG-------------VVPTPIPI-CREYCLAV KELFCAKEWLA------------------------------------------------- ----------------------------------ME--EKTHRGLYRSEMH----LLS-- -VPECSKLPSMH--WDPTACARLPHLD-YNKENLKTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPN LPSSSSSSFSVSPTYSMTVI---ISIMSSFAIFVLLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HTVCS------L SHSDLS-MRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPVELYN-LMRLCWSKLPADRPSFTSIHRILERMCERA EGTVSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >B_taurus_ENSBTAP00000003558 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------EFVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------EIYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCIANN------------------- ------------------------------------------------------------ -------GVGGAAESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SALR-ENSR-------TAV-----LESGSLRIHNV QKEDAG----HYRCVAKNSLGTAYSKLVKLEVE------------VFARILRAPESHNVT FGSF-VTLRCTATGIPVPTIT-WIENGNSVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATISIAE--------------------- ------------------------------------------WSKPQKDNKGYCGQYRGE VCNAVLAKDALVFFNN-SYA--DPEEAQELLVHAA---------WNELKAVS-PF----- -----CRPAAEALLCN---HIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------NPG-------------VVPTPMPI-CREYCLAV KELFCAKEWLV------------------------------------------------- ----------------------------------VE--EKTHRELYRSGML----LFS-- -MPDCNKLPSMH--WDPMACTRLPYLD-YKKENLTTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPN APSSSSPSFSVSPAYSMTVI---ISIMSSFAVFVLLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMAP-HPGRG------L SPSDLP-PGSQASSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPLELYN-LMRLCWSKVPADRPSFSSIHRILERMCERA EGRGGV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >M_mulatta_ENSMMUP00000039675 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SPLR-ENSR-------TAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKVVKLEVE------------VFARILRAPESHNVT FGSF-VTLHCTATGIPVPTIT-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATVSIAE--------------------- ------------------------------------MLFISSFSKPQKDNKGYCAQYRGE VCNAVLAKDALVFLNT-SYA--DPEEAQELLVHTA---------WNELKVVS-PL----- -----CRPAAEALLCN---HVFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SPG-------------VVPTPIPI-CREYCLAV KELFCAKEWLA------------------------------------------------- ----------------------------------ME--EKTHRGLYRSEMH----LLS-- -VPECSKLPSMH--WDPTACARLPHLD-YNKENPKTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPN LPSSSSSSFSVSPTYSMTVI---ISIMSSFAIFALLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HTVCS------L SHSDLS-MRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPVELYN-LMRLCWSKLPADRPSFTSIHRILERMCERA EGTVSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >M_musculus_ENSMUSP00000095665 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLLQMLT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCIANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----NALR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKLVKLEVE--EDREPEQDAKVFARILRAPESHNVT FGSF-VTLRCTAIGIPVPTIS-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATVSIAV--------------------- -------------------------PPP--WFSMDTSFLWTEWSKSQKDSQGYCAQYRGE VCDAVLAKDALVFFNT-SYR--DPEDAQELLIHTA---------WNELKAVS-PL----- -----CRPAAEALLCN---HLFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SPG-------------VVPTPMPI-CREYCLAV KELFCAKEWQA------------------------------------------------- ----------------------------------ME--GKAHRGLYRSGMH----LLP-- -VPECSKLPSMH--RDPTACTRLPYLD-YKKENITTFP---------------------- ------------------------------------------------------------ -------------------------------------------SITSSRP----SADIPN LP-ASTSSFAVSPAYSMTVI---ISIVSSFALFALLTIATLY--CCR---------RRKE WKN--------------------------------------------KK----REST--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HTVCS------L SHSDLS-TRARVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGET MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILACPENCPLELYN-LMRLCWSKLPADRPSFCSIHRILQRMCERA EGTVGV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >C_familiaris_ENSCAFP00000004412 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAAESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SALR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----HYRCVAKNSLGTAYSKLVKLEVE--EESEPEQDTKVFARILRAPESHNVT FGSF-VTLRCTATGIPVPTIS-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLFTCIATNKHGEKFSTAKAAATISIAE--------------------- ------------------------------------------WSKLQKDNKGYCAQYRGE VCNAVLAKDALVFFNN-SYA--DPEEAQELLVHTA---------WNELKAVS-PF----- -----CRPAAEALLCN---HIFQGC----------------------------------- ------------------------------------------------------------ ---------------------------NPG-------------VVPTPTPI-CREYCLAV KELFCAKEWLA------------------------------------------------- ----------------------------------ME--EKAHRGLYRSGMH----LLS-- -VPECNKLPSMH--WDPTACTRLPYLD-YKKENLTTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMTSSKP----SVDIPD LPSSSSSSFSVSPTYSMTVI---ISIMSSSAIFVLLTVTTFY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSRSP------------- ----------------------CAQQLGIARQVAAGMAYLAERKFVHRDLATRNCLVGDG MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGLAHE E----------------------------------------------------------V IRYV-----RAGR--TLARPARCPLELYN-LMRLCWSPLPADRPGFPGIHRILQRMCDAA DAADRA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >D_melanogaster_FBpp0079568 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MNKYSAFIVCI S---------LVLLFTKKDVGSHNVDSRIYGFQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QSSGICHIYNGT ICRDVLSNAHVFVSPN-LTM--NDLEERLKAAYGV---------IKESKDMN-AN----- -----CRMYALPSLCF---SSMPICRTPERTNLLY------FANVATNAKQLKNVSIRRK RTKSKDIKN--------------------------------------------------- ----------ISIFKKKSTIYEDVFSTDISS------KYPPTRESENLKRI-CREECELL ENELCQKEYAI------------------------------------------------- ----------------------------------AKRHPVIGM-------------VG-- -VEDCQKL------PQHKDCLSLGITI---EVDKTENCYWEDGSTYRG------------ --------VANVSASGKPCLRWSWL--------------------MKEISDFPEL-IGQN YCRNP--GSVENSPWCF-VDSSRERIIELCDIPKCADK---------------------- --------------IWIAI-----VGTTAAIILIFIIIFAIILFKRR--------TIMHY GMR---------------------------NIHNINTPSADKNIYGNSQL---NNAQDAG RGNLGNLSD--------------------------------------------------- -------------------------------------HVALNSKLI-------------- ------ERNTLLRINHFTLQDVEFLEELGEGAFGKVYKG-QLLQ---------------- PNKTTITVAIKA---------LKENASVKTQQDFKREIELIS-----DLKHQNIVCIL-- ---------------GVVLNKEPYCMLFEY-MANGDLHEFL-ISNSPTEG---------- ------------------KSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEG LVVKIS-DFGLSRDIYSSDYYR-------------------------------------- -------VQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGM-QPYYGFSNQ E----------------------------------------------------------V INLI-----RSRQ--LLSAPENCPTAVYS-LMIECWHEQSVKRPTFTDISNRLKTWHEGH FKASNPEM---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >E_caballus_ENSECAP00000008277 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLVHILT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTKNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCIANN------------------- ------------------------------------------------------------ -------GVGGAAESCGAL----QV---KM-KPKITR-PP-INVKITEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVT-------WIKGD-----HALR-ENAR-------IAV-----LESGSLRIHNV QKEDAG----HYRCVAKNSLGTAYSKLVKLEVE------------VFARILRAPESHNVT FGSF-VTLRCTATGIPVPTIT-WIENGNAVSSGSIQESV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATISIAE--------------------- ------------------------------------------WSKPQKDNKGYCAQYRGE VCNAVLAKDALVFFNN-SYA--DPEEAQELLVHSA---------WNELNTVS-PF----- -----CRPAAEALLCN---HIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------NPG-------------VVPTPIPI-CREYCLAV KELFCAKEWLE------------------------------------------------- ----------------------------------ME--EKTHRGLYRSGMH----LLS-- -VPECNKLPSMH--WDPMACTRLPYLD-YKKENLTTFP---------------------- ------------------------------------------------------------ -------------------------------------------PMPSSKP----SVDIPD LPSSSSSSFAVSPTYSMTVI---ISIMSSFAIFVLLTITTLY--CCR---------RRKQ WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEFL-RSMSP-HSVCS------L SHSDLS-TRAQVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPLELYN-LMRLCWSKLPADRPSFTSIHRILERMCERA EGTVSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >M_domestica_ENSMODP00000004898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MCAV----------ESYPQPEIAWTRNKIL------ -IKLSDTRYSIRENGQLLTILSVE----DSDDGVYCCTANN------------------- ------------------------------------------------------------ -------GVGVAAESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----TILR-ENTR-------IAI-----LESGSLRIHNV QREDAG----HYRCVAKNSLGTAYSKLVMLEVE------------VFARILRAPESHNVT FGSI-VTLRCTATGIPVPTIT-WLENGNAVSAGSILESV-----KDRVI----DSQLQ-- LLITKP-----GLFTCIATNKHGEKFSTVKAAATISISG--------------------- -------------------------------------YIFGTKYKLPQEDPGYCSTYRGE VCGAVLAKDALVFYNS-SYQ--DSGDAQELLVQTI---------WSDLKALS-PL----- -----CQPAMESLLCN---HIFQGC----------------------------------- ------------------------------------------------------------ ---------------------------NPAR------------FMPTPKPL-CREHCLAV KDLFCAKEWLA------------------------------------------------- ----------------------------------LE--EKAHKGLYKSGLH----LFT-- -LPECTKLPSMH--REPMACTKVPHLEKYNKKTNNEFT---------------------- ------------------------------------------------------------ -------------------------------------------PLVTVKP----SADIPD WSSSSS---TFSPTYSMTVI---IAIISSFAVIGFLTMTALL--CCR--------QRRRQ WKN--------------------------------------------KK----RESA--T PTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLR-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDHPNIVRLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEYL-RNMSP-RTMCH------L SHSNLA-TRVRLSSPGP-PPLCCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGNN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IFYV-----RDGN--ILSCPENCPLELYN-LMRLCWSKLPTDRPSFTSIHRILQRMCERA EAAVGV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >T_guttata_ENSTGUP00000001342 -----------------------------------------MN----------------- ------------------------------------------------------------ --------------------------------DLLKVPLLHVLT-----LAALSLAETLL KA--PLISTPLETVDALVEDIAKFVCVV----------ESYPEPEITWTRNSIP------ -IRLFDTRYSIQRNGQLLTILSVE----DTDDGVYCCTADN------------------- ------------------------------------------------------------ -------GVGAAAQSCGAL----QV---KM-RPKITR-PP-VNVEIIEGLK-A------- -----------------------------------------------------VLPCTTM GSPKPSVS-------WVKGE-----TVVK-ETAR-------IAV-----LDSGNLRIHNV QREDAG----QYRCVAKNSLGTAYSKPATVVVE------------VFARILKAPESQNIT FGSV-VTLRCTATGLPVPTVT-WLENGKAVSVGSIAESV-----KDRVV----DSRLQ-- VYVTRP-----GLFTCLASNKHSKTFGAAKAAATISISA--------------------- -----------------------------------------YSVKLYKGDAGYCSTYRGE VCSAILAKNALVFFNS-SYA--DPEETQELLVHAA---------WTELKMVS-SF----- -----CQPAAESLLCN---YIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------AGPAPKPV-CRENCLAV KDLYCFKEWLS------------------------------------------------- ----------------------------------ME--ENSQKGIYKPGLM----LLT-- -LPECNRLPSLH--QNPSSCTHIPFFD-FKKENITRTCYSGNGQFYQG------------ --------TANVTASGIPCQKWSDQ---------------APHLHRRTPQVFPELFDAEN YCRNP--GGENERPWCYTKD--PAVTWEYCSVSPCGDAL---LSLGTRKP----NGEPLN LP-PPP---PFSPTYSMTVI---ISIISSFALVVIFAIITLV--CCR---------SRKQ WKN--------------------------------------------KK----RESE--T PTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPHIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEYL-RDRSP-RNLCS------L VQGSLD-TRLRL--PNP-LALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNMYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGM-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--VLSCPDNCPLELYN-LMRLCWSRLPADRPGFASIHRILERMYKKA VANMSV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_latipes_ENSORLP00000015124 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -A--PRIITLLETVDVLLDHNATFICEV----------ESRPPAIITWTKNNHP------ -IKYYDTRYLTREKGQMLVIPHVR----ESDNGEYCCLASN------------------- ------------------------------------------------------------ -------GIGEPAKSCGAL----QL---KM-KPQIKQ-QP-RNLTLVITSK-A------- -----------------------------------------------------VLPCFTL GNPKPEIT-------WLKDN-----NPVK-FSEG-------ITI-----LDSGALKIHNI QKEDAG----QYRCVAKNSFGLALSKTVTIEVQ------------APARILRAPKEKRAP SGSQ-ITLECNATGIPIPTIT-WLENGNAISGASVEETI-----VGDVI----LSVLK-- VTVVKH-----ALYTCMASNRHSGGANTVKATAGVTVAE--------------------- ------------------------------------------WRRLFKSSSGYCSAYRGE VCQTVLQDNFLVFFNA-SLS--DPEDMQEYLVQSW---------WTELEGLS-TL----- -----CSPALLSLLCH---SSFPNC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------LGPAPKPV-CREHCLAV KELYCYKEWLL------------------------------------------------- ----------------------------------LEGSRSVQPELFDSVLG----SHY-- -LPKCQALPSLH--ADPDACTHVPFLD-LSKDEITTTCYNDKGRLYQG------------ --------NINVTRSGIPCQPWNQQQ--------------VPHQHRLSVDIIPELKNSHN HCRNP--GGISDRPWCYTSN--PNIRLEYCVVPQCGKTT---IPPAVIKP--ESTRQNPH LPPTTS---VSSPAYSMSVI---VIVLTSFAITVALSIVILS--CYR---------RRKQ WAN--------------------------------------------RKR---REMK--M PTLSALPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRVPL--------------- ------LLNSKLLGLEYPRNNIQYVRDIGEGAFGRVFQA-RAPGLL-------------- QNKPFTMVAVKM---------LKEEASPDMQNDFQREAALMA-----EFDHPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MANGDLNEFL-RRHSPTQSMHT------L SCPSIS-NRSFSSDMEA-GSLSCVQQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEE MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTIESDVWAYGVVLWEIFSHGM-QPYYGMGHE E----------------------------------------------------------V IYYV-----RDGQ--ILACPENCPLELYN-LMRLCWSTQPSDRPSFSSIHRILERMHQNK LNTNTD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >T_nigroviridis_ENSTNIP00000005174 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LP SA--PRIITLLETLDVLTDHNATFICEV----------ESRPPADVTWTKNNHP------ -IMYYDPRYVTQAQGQMLTVPHVR----ESDSGEYCCIATN------------------- ------------------------------------------------------------ -------GVGEPAKSCGAL----QL---KMTEPQIKR-HP-TNLTLLVESK-A------- -----------------------------------------------------VLPCVTL GNPKPDVT-------WLKDD-----ELIK-ISDR-------VTI-----LDYGALKIHNV RKEDAG----QYRCVARNSFGLSISKPVTIEVQ------------VPARILQVPKESKVA YGGL-VSLQCNATGNPVPTIT-WLENGNTISGASVDEAL-----SGDVI----QSVLK-- VRVSKP-----ALYTCLASNRHSAGANTVKASARVTVAE--------------------- -------------------------------------------WRLYKGAAGYCSGYRGD VCRAILQDDQLVFFNS-SLP--DPEDLQEYLVQSL---------WPALEGLG-AA----- -----CGPAMHSLLCH---SAFPDC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------FGPAPKPV-CREHCLAV KELYCQREWAV------------------------------------------------- ----------------------------------LEGSASAQSGLFRSATGSSRPSSL-- -LPNCQALPSLH--ADPDICTHVPFTD-IKTDQITTSCYSDRGRFYQG------------ --------GVNVTRSGTPCQHWNHQ---------------LPHQHQLSADVIPELKNSRN YCRNP--GGVSDRPWCYTSN--PSVRWESCPVPECGETS-------------AASEQTPR VLPPTT---VSHPAYSMSVI---VIVLSALAAAVLFTIVILA--CRR---------QRKQ WRN--------------------------------------------RK----RVME--T PTLSALPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRVPL--------------- ------LLNSKLLALEYPRNNIQYVRDIGEGAFGRVFQASRAPGLL-------------- PMESFTMVAVKM---------LKEEASADMQNDFQREAALMA-----QFDHPNIVKLL-- ---------------GVCAVGKPMCLMFEY-MAHGDLNEFL-RRRSPDQSVRT------I SRASLS-GRSFTSELEA-GLLSCADQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGEE MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSHGM-QPYYGMGHE E----------------------------------------------------------V IYYV-----RDGH--ILSCPENCPLELYN-LMRLCWSSQPPERPSFSSIHRILERMHQNT LNTDTE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_aculeatus_ENSGACP00000024106 -----------------------------------------KK----------------- ------------------------------------------------------------ --------------------------------NPDLVPLVIEKL-----SCFLCIVHTLH IA--PRIITLLETLDVLLDHNATFICEV----------ESRPRADISWTKNNYP------ -IMYYDPRYITREHGQMLSIPHVR----ETDNGEYCCLATN------------------- ------------------------------------------------------------ -------GIGEAAKSCGAL----QL---KM-KPQIKR-HP-TNVTLLVESK-A------- -----------------------------------------------------VLPCVTL GNPKPDVT-------WLKDD-----ELIK-VSDR-------VTI-----LDYGALKIHHI QKEDAG----QYRCVARNSFGLAFSKPVTIEIQ------------APARILRVPKEKRVA YGSL-ISLECNATGNPIPTIT-WLENGNTILGASVEETL-----TGEVI----LSVLK-- VTVNKP-----ALYTCLASNRHSTGANTAKATAKIIVAE--------------------- -------------------------------------------WRLYKGVTGYCSAYRGD ECRTVLQDDLLVFFNS-SLS--DPEDMQEYLVQSW---------WTELEGLS-TL----- -----CSPAARALLCH---ASFPDC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------SGPAPKPV-CREHCLAV KELYCYKEWLV------------------------------------------------- ----------------------------------LEGSSSVQSGFFSSAS-----TSL-- -LPNCQALPSLH--ADSDACTHVPFVD-IKKDQITTACFSEKGRFYQG------------ --------TANVTRSGVPCQSWSQQ---------------VPHEHRLSVDVIPELKNSAN YCRNP--GGISDKPWCYTSN--PNIRWEYCAVPRCGETS----IEPVMKPELPGPRQTTR LPPMAK---PSSPAYSMSVI---VILLTVLAAAVFIFICILA--CHR---------RRKQ WRN--------------------------------------------RKS---RAME--T PTMSALPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRVPL--------------- ------LLNSKLMALEYPRNNIQYVRDIGEGAFGRVFQA-RAPGLL-------------- QIESFTMVAVKM---------LKEEASDDMQNDFQREAALMA-----QFDHPNIVRLL-- ---------------GVCAVGKPMCLMFEY-MAHGDLNEFL-RHRSPSQSVRT------L SRGSLS-GRSFSSELEA-GLLSCTEQLSVSKQIAAGMAYLSERKFVHRDLATRNCLVGEE MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSNGM-QPYYGMGHE E----------------------------------------------------------V IYYV-----RDGH--ILACPENCPLELYN-LMRLCWSTHSSDRPSFSSIHRILERMHQST RSISGEA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_gallus_ENSGALP00000025318 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -A--PFISTPLETVDALVEDVAKFVCVV----------ESYPEPEITWTRNSIP------ -IRLFDTRYSIQRNGQLLTILSVE----DSDDGVYCCTADN------------------- ------------------------------------------------------------ -------GVGAAAQSCGAL----QV---KM-RPKITR-PP-VNVEIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGE-----TVVK-ENAR-------IAV-----LDSGNLRIHNV QREDAG----QYRCVAKNSLGSAYSKPATVIVE------------VFARILKAPESQNIT FGSM-VTLRCTAAGAPVPTVT-WLENGKAVSAGSIAESV-----KDRVV----DSRLQ-- VYVTRP-----GLFTCLATNKHSKTFGAAKAAATISVSG--------------------- ------------------------------------------VPKLYKGDAGYCSTYRGE VCSAILSRNALVFFNS-SYA--DPEETQELLVHTA---------WTELKTVS-SF----- -----CQPAAESLLCN---YIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------KPSG------------VGPAPKPI-CRENCLAV KDLYCFKEWLS------------------------------------------------- ----------------------------------ME--ENSQRGIYKPGLM----LLA-- -LPECNRLPSLH--QDPSACTHIPFFD-FKKENITRTCYSGNGQFYQG------------ --------WANVTASGIPCQKWSDQ---------------APHLHKRTPQVFPELSDAEN YCRNP--GGENERPWCYTKD--PSVTWEYCSVSPCGDAS---LSLGTRKP----NGETQN LP-PPP---SYSPTYSMNVI---ILIISSFALIVILGIITLV--CCR---------RRKQ WKN--------------------------------------------KK----RESE--T PTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAYGDLNEYL-RDRSP-RNLCS------L VQGGLE-ARACL--LNP-LALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNMYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGM-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPDNCPLELYN-LMRLCWSKLPADRPSFASIHRILERMYERA VASPQV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_anatinus_ENSOANP00000011101 -----------------------------------------MK----------------- ------------------------------------------------------------ --------------------------------DLINIPLLHIL------LAALSLAEKLP QA--PVITTPLETMDASVEGTATFICAV----------DSYPQPEIAWTRNKIL------ -IKMFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGEAAESCGAL----QV---KM-KPKITR-PP-INVKITEGLK-V------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGE-----TTLK-ENAR-------IAV-----LESGNLRIHNV QREDAG----HYRCLAKNSLGTAYSKPVMLEVEAIEESEPERDTKVFARILRAPESHNVT FGSI-VKLRCTATGIPVPTVT-WLENGNVVSTGSILESV-----KDRVI----DSQLQ-- LFITRP-----GLFTCIATNKHGEKLSTAKAAATISVSE--------------------- -------------------------APASWEHKIQSCVWINFSSKLYKGDTGYCSTYKGE VCSAVLVKDALVFFNS-SYA--DSEKIQEMLAQAV---------WSELKTVS-LL----- -----CRQAAESLLCN---HVFQEC----------------------------------- ------------------------------------------------------------ ---------------------------HPTA------------VIPTPKPI-CREHCLAV RDQYCSNDWLT------------------------------------------------- ----------------------------------ME--AKSHKGLYQSGLH----QLI-- -LPECSKLPSMH--VDPTACTKIPYFE-YRKENITTAP---------------------- ------------------------------------------------------------ -------------------------------------------SPVTAKS----SAEIPN LPSSSS---SFSPTYSMTVI---ISIMSSFAVIGLFTITTLV--CCR---------RRKQ WKN--------------------------------------------KS----KESA--T PTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- SYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDDPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAFGDLNEFL-RNMSP-RTVCS------L SHGNLV-PRMRISSPGP-PPLCCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPENCPLELYN-LMRLCWSKLPADRPSFTSIHRILARMCERA EAAMHA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >D_rerio_ENSDARP00000028386 -----------------------------------------MK----------------- ------------------------------------------------------------ --------------------------------VPKNTPLV--VF-----LAFFSLTEGLQ RA--PRITTLLETVDSSLDHNATFICEV----------DSYPQADIIWTRNNYP------ -IRYYDSRYVIQENGQMLIIPNVK----DSDSGEYCCIANN------------------- ------------------------------------------------------------ -------GVGE-AKSCGAL----QL---KM-KPQIKR-HP-TNMTLILESK-A------- -----------------------------------------------------VLPCLSL GYPKPEIS-------WIKED-----DLIK-ANNR-------IAI-----LESGSLKITNI KKEDAG----QYRCVARNSFGIAFSRPVTIEVQ------------APAKILKVPKEKRVQ IGSE-VTLECNATGNPIPSIT-WLENGNTISGASVVETL-----VGEVI----LSVLQ-- VVVHKP-----ALYTCQATNRHSGGENTVKATAKITVSV--------------------- -------------------------------------------FRLYKGHAGYCSTYRGD VCRNVLRRDALVFFNY-SLP--NPEDAQEYLAQSA---------WPELDGVS-SF----- -----CRPAARSLLCH---STFQDC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------LGPAPKPV-CREHCLTV KELYCYKEWRS------------------------------------------------- ----------------------------------AE--ERSQRGFQ---------HIT-- -LPECTSLPSQQ--ADPSSCTAVPYVD-IKKDQVTSTCYNDKGRFYQG------------ --------THNVTASSIPCQRWNQQ---------------DPHQHRLSVDVIPELRNAEN YCRNP--GGESDRPWCYTTN--PNVRWEYCLVPKCGEVISIRTAPSITKP--------AH FYPPPS----VSTAYSMSVI---IFVIAGFAGAAFFTVLILM--CHR---------RKKM WKK--------------------------------------------RKS---RVLE--T PTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRLPL--------------- ------LLNSKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PTEPFTMVAVKM---------LKEEASTDMQNDFQREAALMS-----EFDHPNIVRLL-- ---------------GVCAVGKPMCLMFEY-MAYGDLNEFL-RRRCA-TQQPS------L SRDTLT-SSSLVSEPERYPPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAEN LVVKIA-DFGLSRNIYAADYYK-------------------------------------- -------ASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGM-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--VLSCPENCPQELYN-LMRLCWSGHPTDRPSFASIHRILERMHDQM LKSGLS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_carolinensis_ENSACAP00000001066 ------------------------------------------------------------ WGLGCLVLLGGWRAPLASASACPAPCACSPERIWCSEPAPSLRSFPVLGKRSE------- -------REKIADI------------------YIANQRQLESIN-----EIDVGLYTGLK NL--TVVDSGLKFVSRQAFLKNTNLQYI-------NLSRNK-LSSLSRKSFRHLNLSD-- -LILEGNPFKCSCDIMWIKVFQESKNP-KTETQDFYCMNDN------------------- ------------------------------------------------------------ -------NQRISLMEKPVP----NC---GL--PSVKL-ST-HNFTVVEGGS-I------- -----------------------------------------------------TLYCDAS GSPPPSIS-------WLFNN-----IAS--KYES-------DTN-----KNPASLTIKNV FSNDSG---VQISCVAENSVGED-QDSVDLAVF------------FPPNITFLEVPYP-- -DHH-WCIPFSVRGNPQPTLT-WLHDGVKLNETDFIFTK-----IHDSN----RSEHHGC LHLDNPTHVNNGNYTLVAQNPYGKDEANITAY---------------------------- ------------------------------------------------------------ ------------FMED-PGD-LLSKSEANR------------------------------ -----PWLFDDYGTTT---NDFEDT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TNNSNPVTSTDVSNKD---------- ---NED-------SITVYVV----VGIAALVCTGLVIMLIIL-KFGR---------HSKF GMK---------------------------GPSSVISNDDDSASPLHHIS---NGSN--T PSSSEGGPD-------------------AVII---------GMTKIP------------- --------------------------------VIEN-PQYFGITNS-------------- ------QLKPDT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_aegypti_AAEL010374-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GVCQVYSGT TCEAYLKNQTVFITPD-ITM--EILEERLKAAYGV---------IRESKDMN-AN----- -----CRVYALPSLCY---SILPVCQTPEKTNHQY------FANKRAAEA---------- ---------------------------------------------------NSLD---DG ERRRQRRSSNRNFLQLNTYGIDDRYFSSFSANSNNKKNYPPTRNTENLRRI-CRNDCELL ENELCQKEYAI------------------------------------------------- ----------------------------------AKRHPTIGQ------------KLP-- -LEECDDL------PLQNSCMRLGIEI---DVNKDDDCYWENGYSYRG------------ --------ILDKSNTGNPCMRWSKL--------------------MREISNYPEL-AGHN YCRNP--GGELSSPWCY-VD--LKKTMELCEITRCSER---------------------- --------------MWLYII----VGFVAFCTLIVVIVTIVC--CRK---------YRKH GVS---------------------------NIQNINLPNADKNIYGNSRH---NSPIEMT SLITNQNST-------------------GAIS---------------------------- -----------------------------------------QTSQS-------------- ------RNNGIARVPQYTLQDVRFVEELGEGAFGKVYKG-ELTQ---------------- KDGEKIFVAVKA---------LKENASAKTQADFKREIELIS-----DLKHDNIVCIL-- ---------------GVVLKEEPLCMLFEY-MAQGDLHEFL-IANSPNEG---------- ------------------KQLTQLQFLLISQQICDGMEYLASHHYVHRDLAARNCLVGDN LTVKIS-DFGLSRDIYSSDYYR-------------------------------------- -------VQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGL-QPYYGYSNQ E----------------------------------------------------------V INMV-----RARQ--LLPCPEACPSAVYS-LMVECWHEQAVRRPTFPEIGHRLKIWYQAQ KRSMFVV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_carolinensis_ENSACAP00000001049 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------DSLNIPLVHIFT-----LAAFSLAERLP KA--PMIITPLETVDALVEEEATFECVV----------ESFPQAEITWTRNNIP------ -IRLFDTRYSIRENGQLLKILSVE----DSDDGVYCCTANN------------------- ------------------------------------------------------------ -------GVGVTAENCGAL----QV---KM-KPKITR-PP-SNVKIIEGLK-A------- -----------------------------------------------------VFPCTTM GNPKPSVS-------WIKGE-----NVVK-ENTR-------IAI-----LESGSLRIHNV QREDGG----HYRCVAKNSLGTAYSKPVILEVE------------VFARILKAPESYNIS FGSV-VTLQCAATGIPTPTVA-WLENGKAVSAGSIVETV-----KDRVI----DSRLQ-- VYVTRP-----GLFTCIATNKHSETYGTAKAAATINVSG--------------------- -------------------------------------------IRLYKGDAGYCSTYRGE VCRALLAKDAFVFFNA-SYG--DPEETQELLVRTA---------LTELKTVS-PL----- -----CRPAAESLLCH---YIFQEC----------------------------------- ------------------------------------------------------------ ---------------------------NPSR------------TGPAPKPV-CREHCLAV KDLYCFKEWLS------------------------------------------------- ----------------------------------ME--ENARRGIYKPGLM----LLT-- -LPECNRLPSLH--QDPKACTWIPHLD-HKDHPVQNQP---------------------- ------------------------------------------------------------ ------------------------------------------LSEATTKP----NELVPY YPS------SFSPTYSMTVI---ISIICSFAMLIILAITVLI--CCR---------RRKQ WKN--------------------------------------------KT----RESV--P PALTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLFSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GVCAVGKPMCLLFEY-MAFGDLNEYL-RNRSP-CNLCS------L NDNNFE-IGIRPSSPNM-LTLSCTNQLYIAKQVAAGMAYLSERKFVHRDLATRNCLVGED MVVKIA-DFGLSRNMYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFAFGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILSCPDNCPLELYN-LMRLCWSKLPSDRPGFASIHLILERMYERA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_gambiae_AGAP006219-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MFVCTSFLIVHSPTLSLSLSLSPF-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SRLTFTPSGTAGYARTASAGNGSS--------------------------- ------------------------------------------------------------ ----SNSYSPNGKFKRRKKTEKLHQQQQQDAL---------------------------- --------------------------------------------EEDTIEPGVCQVYTGT TCEQYLRNQTVFVTPD-ITM--EILEERLKSAYGV---------IRESKDMN-AN----- -----CRVYALPSLCY---SILPVCRTPELTNHQY------FANRAAAEAAQRAATIGRG KMRAHEKKNNRKQLLRGNGTLTTTERLRVYFSGGVTPDLGGRFFDGEIVTENSLPPRYDN ARRGRRAAGHQQYVQ---PGEEITVLSYTSSSSGPKKSYPPTRNTENLRRI-CRNDCELL ENELCQKEYAI------------------------------------------------- ----------------------------------AKRHPTIGQ------------KLP-- -LEECDDL------PLQKSCMRLGIDL---DIKPNDDCYWENGASYRG------------ --------IMDRTKSSKICMRWSKL--------------------MHTMSEFPHL-AGHN YCRNPPHAGPMDAPWCY-VD--MQKTIEYCDIPKCSER---------------------- --------------MWMYII----IGFVAVISPLFIGIGVFC--CRK---------YRKH GVS---------------------------NIQNINLPNADKNIYGNSRL---NSPIEMT SLIANQSST-------------------GAASRNAENGGIQGLTTG-------------- --------------------------------QPGNGHNPGQSSQS-------------- ------RNNGISRVPQYTLQDVRFVEELGEGAFGKVYKG-ELTQ---------------- KNGERIFVAVKA---------LKENASAKTQADFKREIELIS-----DLKHDNIVCIL-- ---------------GVVLKEEPLCMLFEY-MAQGDLHEFL-IANSPNEG---------- ------------------KSLSQLQFLLIAQQICDGMEYLASHHYVHRDLAARNCLVGDN LTVKIS-DFGLSRDIYSSDYYR-------------------------------------- -------VQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGL-QPYYGYSNQ E----------------------------------------------------------V INMV-----RARQ--LLPCPESCPSAVYS-LMVECWHEQAVRRPTFPEIGHRLKIWYQAQ KRSKC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >T_rubripes_ENSTRUP00000007874 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LC AA--PRIITFLETLDVLMDHNATFICEV----------ESRPPADVTWTKNNHP------ -IMYYDPRYATRAQGQMLIIPHVR----ESDSGEYCCIATN------------------- ------------------------------------------------------------ -------GVGEPAKSCGAL----QL---KM-KPQIKR-HP-TNLTLLVEAK-A------- -----------------------------------------------------VLPCVTL GNPKPDVT-------WLKDD-----ELIK-ISDR-------VTI-----LDYGALKIHNI QKEDAG----QYRCVARNSFGLSISKPVSIEVQ------------VPARILQVPKERKVA YGSL-VSLECNATGNPVPTIT-WLENGNTISGASVDETL-----SGDVV----QSVLK-- ATVHKP-----ALYTCLASNRHSAGANTVKASARVTVAARHAGGSGSGGGWRRGHKGGRR SSMVGFSFRRRLTLVSCPPGVSCVLLLMFLQPSSAASCGSTPEWRLYKGSAGYCGAYRGD VCGAVLPGDHLVFFNS-SLP--DPEDLQEYLVQSL---------WPKLEGLG-SA----- -----CSPAMHSLLCH---SAFPDC----------------------------------- ------------------------------------------------------------ ---------------------------NPSG------------IGPAPKPV-CREHCLAV KELYCQGKWAV------------------------------------------------- ----------------------------------LEGGASAQSGLFRSGTGSSGTSSL-- -VPNCQALPSLQ--EDPNACTHVPFAD-LKLDQITTTCFSDRGRFYQG------------ --------GVNVTRSGTPCQPWNHQVIRTFQPESEPTQLLLPHQHRLSADVIPELRNSRN YCRNP--GGISEGPWCYTSN--PNIRWEFCPVPPCGETS--------------------- ----------VAPAYSMSVI---IIVLSTLAAAVLFTIAVLA--CRR---------QRKQ WRN--------------------------------------------RK----RVME--T PTLSALPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRVPL--------------- ------LLNSKLLALEYPRNNIQYVRDIGEGAFGRVFQA-RAPGLL-------------- PMESFTMVAVKM---------LKEEASADMQNDFQREAALMA-----QFDHPNIVKLLXE PRVKVVNCSCLYPPTGVCAVGKPMCLMFEY-MAHGDLNEFL-RRRSPNRSLRT------I SRASLS-GRSFTSELEA-GLLSCADQLSISKQIAAGMAYLSERKFVHRDLATRNCLVGED MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ANENDAIPIRWMPPESIFYNRYTTESDIWAYGVVLWEIFSHGM-QPYYGMGHE E----------------------------------------------------------V IYYV-----RDGH--ILSCPENCPMELYN-LMRLCWSSQPSDRPGFSSIHRILERMH--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_aegypti_AAEL001370-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MIAAKQWFALFLL------------------------------- ACVVWM-----QSVVESAS---SDGLSTVGGE---------------------------- ------------------------------------------FDDPSDDEEGYCAPYNGK VCKTFVKGRQVWYNR--DGS--GGWLNEQITTALF---------RDLITDLP-DY----- -----CRPAAEKLLCA---FAFPQC----------------------------------- ------------------------------------------------------------ ---------------------------VIRD------------GVTVRLPL-CYEDCVAT HLQFCYNDWAL------------------------------------------------- ----------------------------------IE--EKKERGDVIKSRG----HFR-- -LPNCEDLPRYNKTARHSTCSHVGLTE-LIQEEVTYDCRMGNGRYYLG------------ --------TVNVTATGIPCQKWDSQ---------------EPHSHHKPPLVFAELQDAEN YCRNA--GGEEPTPWCYTTD--KAVRWQACDIPLCPNST---DMSATKKP--------VN IV-MES---VFTP--SMIFL---LSGI-GFVAIVLLHLLVFL--CYR---------IARY NRN--------------------------------------------RRQ----GAAGYN TTST-QDTQ-------------------GIDI---------N----K------------- --------------------------------LPSN-VNYHRTGA--------------- ------QLNPKLEKLEFPRNNIIYIKDLGQGAFGRVFQA-KAPGLI-------------- AGEDFTLVAVKM---------LKDEASQDLQVDFEREACLLA-----EFDHPNIVKLL-- ---------------GVCAIGRPMCLLFEF-MARGDLNEFL-RQCSP-FAQQN------R ADNIT-------------TELSHGDLLSIASQIASGMVYLSERKFVHRDLATRNCLIDDN MVVKIA-DFGLSHKIYLQDYYK-------------------------------------- -------GDENDAIPIRWMPLESILYNKYTIESDVWAYGVCLWEIFSFAM-QPYYGMTHE E----------------------------------------------------------V VKFV-----KEGN--MLSCPENTPLTVYD-LMRKCWSRKPADRPSFPIIFQKLQQIRADF DGKMLM------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_gambiae_AGAP006988-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MSDGD---------------------------------------- ------------------------------------------------------------ --------VCTAAGRPPHRRTQWVALLSSVAYVAVGTVL--------------------L ASLTAP-----SPVAAVST---SAAALRHGGGTKDTFG---------------------- ------------------------------------------WDDAGDEEEGYCAPYNGK VCKRFINSRQVWYSRE-DGT--GGWENEKITTALF---------EDLINDLP-PS----- -----CRPAAEKLLCA---YAFPQC----------------------------------- ------------------------------------------------------------ ---------------------------VIKD------------GATIRLPL-CYEDCVAT YLQFCYNDWAL------------------------------------------------- ----------------------------------IE--EKKERGDVIKSRG----HFR-- -LPNCEELPRYNKTAKPPVCSHVGLTE-LVSEEVTYDCRMGNGRFYLG------------ --------TVNVTSTGIPCQKWDSQ---------------EPHSHHKPPLVFAELQDAEN YCRNA--GGEEPTPWCYTMD--KTVRWQACDIPLCPNST---DASDIRGK--------ID MT-MES---VFTP--SMIFL---LSGI-GFVAIVLLHLMVLL--CYR---------VSRH RRN--------------------------------------------RRQ---SGAAGYN PTATAQDGQ-------------------GIDI---------N----K------------- --------------------------------LPSN-VNYHRTGA--------------- ------QLNPKLEKLEFPRNNIIYIKDLGQGAFGRVFQA-KAPGLV-------------- AGEDFTLVAVKM---------LKDEASQDLQVDFEREACLLA-----EFDHPNIVKLL-- ---------------GVCAIGRPMCLLFEF-MARGDLNEFL-RQCSP-FAQQN------R ADSIS-------------TELSHGDLLNIAHQIASGMVYLSERKFVHRDLATRNCLIDDH MVVKIA-DFGLSHKIYLQDYYK-------------------------------------- -------GDENDAIPIRWMPLESILYNKYTIESDVWAYGVCLWEIFSFAM-QPYYGMTHE E----------------------------------------------------------V VKFV-----KEGN--MLGCPENTPLTVYD-LMRKCWSRKPNDRPSFHVIYQKLQQIRADF DGKMLM------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >R_norvegicus_ENSRNOP00000056324 -----------------------------------------MR----------------- ------------------------------------------------------------ --------------------------------ELVNIPLLQMLT-----LVAFSGTEKLP KA--PVITTPLETVDALVEEVATFMCAV----------ESYPQPEISWTRNKIL------ -IKLFDTRYSIRENGQLLTILSVE----DSDDGIYCCTANN------------------- ------------------------------------------------------------ -------GVGGAVESCGAL----QV---KM-KPKITR-PP-INVKIIEGLK-A------- -----------------------------------------------------VLPCTTM GNPKPSVS-------WIKGD-----SALR-ENSR-------IAV-----LESGSLRIHNV QKEDAG----QYRCVAKNSLGTAYSKLVKLEVE--EDSEPERDAKVFARILRAPESHNVT FGSF-VTLRCTAIGMPVPTIS-WIENGNAVSSGSIQENV-----KDRVI----DSRLQ-- LFITKP-----GLYTCIATNKHGEKFSTAKAAATVSIAG--------------------- -------------------------SPI--YSWIDTSMVWRLWSKSQKESKGYCAQYRGE VCDAVLVKDSLVFFNT-SYP--DPEEAQELLIHTA---------WNELKAVS-PL----- -----CRPAAEALLCN---HLFQEC----------------------------------- ------------------------------------------------------------ ---------------------------SSG-------------VLPTPMPI-CREYCLAV KELFCAKEWLA------------------------------------------------- ----------------------------------ME--GKTHRGLYRSGMH----FLP-- -VPECSKLPSMH--QDPTACTRLPYLD-YKKENITTFP---------------------- ------------------------------------------------------------ -------------------------------------------SITSSKP----SVDIPN LP-ASTSSFAVSPAYSMTVI---ISIMSCFAVFALLTITTLY--CCR---------RRRE WKN--------------------------------------------KK----RESA--A VTLTTLPSE--------------------LLL---------D----R------------- --------------------------------LHPN-PMYQRMPL--------------- ------LLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA-RAPGLL-------------- PYEPFTMVAVKM---------LKEEASADMQADFQREAALMA-----EFDNPNIVKLL-- ---------------GMKTEENPMARYSEY-AALWLLHNFL-GSMSP-HTVCS------L SHSDLS-TRARVSSPGP-PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGEN MVVKIA-DFGLSRNIYSADYYK-------------------------------------- -------ADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL-QPYYGMAHE E----------------------------------------------------------V IYYV-----RDGN--ILACPENCPLELYN-LMRLCWSKLPADRPSFCSIHRILQRMCERA EGTVGV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >X_tropicalis_ENSXETP00000025663 --------------------------------------------------MRLWKGSHGP DLTQVCGALWILLALVWRGLACPQYCSCNSTRIWCTLEGKGIVAFPVLEDSAL------- -------AENITDI------------------YIANQRSLASIN-----DDDVKIYTGLR NL--TVVDSGLQIVSRQAFSKNPKLTYI-------NFSKNK-LTSLPKKLFRHLTLSQ-- -LFLGGNPFQCSCDLMWVKVLLETNSL--NQNQNIYCFNDN------------------- ------------------------------------------------------------ -------KKKIPLFTMHIP----NC---GL--PIVNV-ST-LNITVLEGNE-T------- -----------------------------------------------------TLFCDAN GLPDPNVS-------WDISQ-----IIS--KSLK-------ETT-----KRPALLTLKNV TSMDNK---RVIVCVAENSVGED-QVSVELNVH------------FPPVITFIDLPTL-- -DHH-WCIPFSVRGNPKPTLQ-WFHEGSMLSETDFIWSK-----IHETS--NNTSEHHGC LQLDSPTHLNNGFYTLRAENKYGRDERSISAL---------------------------- ------------------------------------------------------------ ------------FMER-PDD-GNDPIT--------------------------------- -----DPGFYDYETTS---NDIGGT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------STDIGTGVTSTDVSKEG---------- ---NED-------SITVYVV----VGIAALVCTGLVIMLIIL-KFGR---------HSKF GLK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GFVLFHSVSLDG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_latipes_ENSORLP00000012786 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MLAATSLN---------KTGSPFIRIDAPMNNITTSLGQT-A------- -----------------------------------------------------ELLCRVS GNPQPEVR-------WLKND-----APV--VQEP-------RRVSIRSMPYGSRLRIRNL DTTDTG----YFQCMASNSKGSV-STTGVLFVK------------FDPHPTPLPGRPMDD FDED-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------GFCQPYRGI ACARFIGNRSIFVDSL-QMQ--GEIETQITAAFTM---------IGTSNQLS-DR----- -----CSQFAIPSLCH---FAFPTC----------------------------------- ------------------------------------------------------------ ---------------------------DRSS------------GSDKPRDL-CKDECEIL ENDLCKTEYII------------------------------------------------- ----------------------------------ARSNPHILKRLK-------------- -LPNCEELAASD-SPEAANCLRIGIPM-PEPINKNHKCYNSSGVDYRG------------ --------TVSVTKSGRQCQPWNSQ---------------YPHSHTYLAVRYPELNGGHS YCRNP--GNKHEAPWCFTLD--EGVRMELCDISICDHNEKA------------------- -------------SGNMEIL---YILVPSVAIPLAIALLFFFICVCR---------NNQM SAR--------------------------------------------------------P PAPRQPKLV--------------------------------------------------- --------------------------------RGQN-LEISVLNT--------------- ------AYKSKGKAKELPLSAVRFMEELGECNFGKIYKG-HLYLP--------------- GMDQAQLVAIKT---------LKDVSNTKQWADFQQESAVLA-----ELQHPNVVCLL-- ---------------GVVTQEHPVCMLFEF-LPQGDLHEFL-IMRSP-HSDVG------C SSDEDGTVK---------SSLDHGDFLHIAIQVSAGMEYLASHFYIHKDLAARNILVGEQ LHVKIS-DLGLSREIYSSDYYC-------------------------------------- -------IQPKTLLPIRWMPPEAIAYGKFTTDSDIWSFGVVLWEIFSYGL-QPYYGFSNQ E----------------------------------------------------------V MEMV-----RKRQ--LLPCPEDCPPRFYG-LMTECWQEGPARRPRFKDIHTRLRAWEGLS SHASSSTPSGGGGNATTQTTSLSASPVSNLSNPRYAAATAAGYLYPAQAIPAPGQMAPIT AWTPMAVPQTHQRFIPVNGYPIPPGYTAFPAHFAPQAPPTRVIQHHLPPPKSRSPSSASG STSTGHVSGVHSTTGSAHEANTPLLSHCIMPGSSGGQAQVYGQVSQKGAAQLDHMSQTSA LLSPDSDIMMYNDSVITADL >D_rerio_ENSDARP00000068113 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EFLQIDLRSLH FITLVGTQGRHAGGIGNEFAQTYKIKYSRDGSRWISWRNRQ------------------- ------------------------------------------------------------ -------GKEVIEGNRNAY----DIVLKDLEPPIIAR-FVRFMPVIDHSMN-V------- -----------------------------------------------------CMRVELY G-----CE-------WL-DG-----LVSYNSPLG-------QQM-----SLN-GQHIYLN DSVYDG---AMSYSSMTEGLGQLTDGMCGLDDF-----TLSHVYNVWPGYDYVGWTNESF PNGY-VEIMFEFDRTRNFTTM-KVHCNNMFSRRVKTFQK-----VVCYF-RSEL-DWEAT PVSFSPVMDDVNPSARFVTVSLYNHMASAIK----------------------------- ------------------------------------------------------------ -CQYYFSDIWMMFSEI-TFQ--S------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ADVTVGDDPTHKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQVWQKMLE----KVSRR MLD---------------------------DELTASLSIQSETFTYNNNN---SPSSVPS EQESSSTYE-RIFPLG-PDYQEP-----SRLVRKLPEFSQ---TSEDTVCAENL------ -----------------AASTITASKTPSV-NVQEGVPHYAEADIVNLQGVTGGNTYAVP ALTMDLLSGKDVAVEEFSRKLLTFKEKLGEGQFGEVHLC-EAEGMQDFMDKDF---SFDV TENQTVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCMSSDPLCMITEY-MENGDLNQFL-SRHEP-EGMIA------- ---LLS-NA---------PTVSYSNLHHMASQIASGMKYLSSLNFVHRDLATRNCLVGKN FTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTSSDVWAFGVTLWEMLTFCKEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQRRQIYLPQPPMCPDPVYK-LMLSCWHRNTKERPSFQEIHHTLLECK--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------P--- >R_norvegicus_ENSRNOP00000003901 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--ILIPRMPL-----VLLLLLLIL---GSAKAQ-----VNPAICRYPLG MSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGNRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DVFLKDLEPPIVAR-FVRLIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGF-IEIMFEFDRVRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSETSEWEPT AVYFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPMAPTT---FDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAVIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNH---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPAQPN--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDANIIRLL-- ---------------AVCITEDPLCMITEY-MENGDLNQFL-SRHEP-LSSGS------- -----S-NA----------TVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQIYLPQPAVCPDSVYK-LMLSCWRRETKHRPSFQEIHLLLLQQGAE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_latipes_ENSORLP00000018947 ------------------------------------------------------------ ------------------------------------------------------------ ------------------VFI-----CILLLLRSFPKRSHISEC-----CVPDVCRYPLG MSGGQIRDEDISASSQWSESTAARHGRLDCEEGDGAWCPETTVEPDNLKEFIQIDLNLLH FITLVGTQGRHAGGMGNEFAQMYMIKYSRDGSRWISWRNRQ------------------- ------------------------------------------------------------ -------GKQVIEGNRNTY----DTVLRDLDPPIIAR-FVRFMPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CK-------WL-DG-----LVSYNAPAG-------EQM-----KLP-AFPVFFN DSVYDG---AITH-MMTEGLGQLSDGVMGLDDF-----TQSHVYQAWPGYDYVGWNNESF PSGF-VEIMFEFDRPRNFTTM-KVHCNNMFSQHIKIFRQ-----VVCYF-RSDS-DWEST VLSFSPVVDENDPSARFITVELTNRMANAIK----------------------------- ------------------------------------------------------------ -CQFYFKDAWMLFSEI-TFQ--SGLLKI-------------------------------- -----VTICQSTLL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SFFFSYRSPEDDPTHKI---------- ---DDS-------NTRILIG----CLVAIIFILLAIIIIILWRQVWQKLME----KASRR MLD---------------------------DELTASLSIQTEVFGHNHSQ---SRVT--N EQESNAAYE-RIFPLG-PDYQEP-----SRLINKLPEFAQ---SSEEPDCSTS------- ------------------TSTASSKSTTTTALVQDGAPHYAEADIVNLQGVTGSNTYAIP AVTLDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EAEGMQEFLHEEY---LFDI PEDQPVLVAVKM---------LRSDANGNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCIYSNPLCMITEY-MENGDLNQFL-SRHEP-EGQLA------- ---LLS-NT---------ATVSFSNLCYMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPYSQLTDE Q----------------------------------------------------------V IENTGEFFRDQKRQIYLPQPVLCSDSLYK-IMLTCWRRNAKERPSFQEIHRRLSDLE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------S--- >T_nigroviridis_ENSTNIP00000016156 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--KHLWRLYL-----LPLVLLHLF---AAVRPQ-----VNTGVCRYPLG MSGGQIQDEDISASSQWSESTAARYGRLDFEEGDGAWCPETTVEPDSLKEFLQIDLRSLH FITLVGTQGRHAGGIGNEFAQMYKIKYSRDGSRWISWRNRQ------------------- ------------------------------------------------------------ -------GEQVIEGNRNTY----DIVLKDLEPPIIAR-FVRFMPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CE-------WL-DG-----LVSYNAPAG-------EQM-----NLP-SFLVYVN DSVYDG---AVTH-SMTEGLGQLTDGVFGLDDF-----TNSCVYKAWPGYDYVGWSNESF PSGY-VEIMFEFDRIRNFTTM-KVHCNNMFSNHVKVFRQ-----VLCHF-RSES-DWEPS PLLFSPAADEKNPSARFVTVSLANHMASAIK----------------------------- ------------------------------------------------------------ -CQFYFADTWMLFSEI-TFQ--SD------------------------------------ -----TAMYNTTLAPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KTGLPPNTPPGEDPTHKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIMLWRQVWQKMLE----KASRR MLD---------------------------DELITSLSIQSETFVYNHNQ---SSGA--S EQESSSTYE-RIFPLG-PDYQEP-----SRFICKLPEFAP---SLEE------------- -----------------PGSTAASKSTTST-VAQDGVPHYAEADVVNLQGVTGSNTYAIP AVTMDLLSGKDVAVEEFPRKMLTFKEKLGEGQFGEVHLC-EAEGMHKFMDKEF---LFDV PEDQPVLVAVKM---------LRSDANKNARSDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCICSDPLCMITEY-MENGDLNQFL-SRHEP-EGQLA------- ---LIS-NA---------STVSFSNLCYMAAQIASGMKYLSSLNFVHRDLATRNCLVGKN FTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPYSQLTDE Q----------------------------------------------------------V IENTGEFFRDQKRQIYLPQPGLCPDSLYK-VMLSCWRRNAKERPSFQEIHTTLLE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >X_tropicalis_ENSXETP00000004517 ------------------------------------------------------------ -------------------------------------MKAGLVPACTAWIPGVLVLL-LL CLGPSAGR--VCGPNMDIRNDVRELKQLEDCVVIEGYLQILLIS-----NAKAEDFRNLR FPKLTVITDYLLLFRVSGLVSLSNLFPNLTVIRGRVLFYNYALVIFEMTDLKEIGLYNLR NITRGAVRIEKNSELCYVSTVDWSLILDAVYNNYIVGNKPP-KECVDLCPGARE------ -KMQICEKSSINN----EFADRCWSDEHCQKACPGVCGKRACTDNKECCHPE-CLGSCMA PDND---TACVACHHYFYE----GRC-VPTCPPNTYKFEGWRCITREECAK-MHIV---- -------VNSLTPFIIHKGEC-------VYE--CPSGFMLNE-----SQ----SMTCSPC EGPCPKVC---DEKMKTIDS-----VTS--AQML-------EGC-----TVLKGNLQLNI R--KG-Q---NIASELENFLGLIETVTGYVKIR------HSHALVSLSFLKSLRYILGEE QMPG-NYSFYVFDNNNLQQLWDWSKHNLTIKEGKIRFAFNSKLCASEIYRMEEVTGTKGR QTAEDISLSTNGNMASCESHVLNFTSIITSKN---------------------------- ------------------------------------------------RIKFTWERYRP- PDYRDLISFTVYYKEA-LFH--NVTEYDGQDACGSNSWNMVDVDLP-----A-SKESDPG IL---LQGLKPWTQYAIYVKAITLTMLES--RHIH------GAKSKIIYIRTDAAVPSIP QDVISASNSSSQLVVKWNSPSQPNGNLSYYIVRWQQQPQDRH-LYQYNYCFRD-K----- -VPNRKYANGTIDTEGVTELTKPEGNTGEKGHCCAC----PKTEAEKKAEK-DEAEYRKV FENFLHNSIFV------------P----------RP------NRRRRDVFAVGNSTQTSH -------GKNTTVEDF-----SNFSDF-------EKEDVEYPFYETKI--DYKRERTV-- -ISNLQPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAAGADDIPGH--VSAKE--EDDGVVFLKWYEPKRPNGLILMYEIEYKQQ- -------GE-VH--R-ECVSRQDFRKTGGAKLTRLSPGNYSAQVQAISLYGNGSWTEPVS FCVKPKPD-VSNNILQMVVA----IPLAFILLLVGIISIGCF-VSKK--------RNSNR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAE--------------- ------MYVPDE--WEVPREKITMNRELGQGSFGMVYEG-IAKGVV-------------- KDEAETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-DTE--------- ---SNS-GQ---------PPPSLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKDELDPG FKEVSFFYSEENKPPDTEELDL----EA--ENMESIPLDP---SCALQT----------- ---------------------------SEHHAGHKSEN--GP------GVVVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >M_musculus_ENSMUSP00000027985 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--IPIPRMPL-----VLLLLLLIL---GSAKAQ-----VNPAICRYPLG MSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DVFLKDLEPPIVAR-FVRLIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGF-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEASEWEPT AVYFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPMAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPAQPN--GPEGVPHYAEADIVNLQGVTGGNTYCVP AVTMDLLSGKDVAVEEFPRKLLAFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITEDPLCMITEY-MENGDLNQFL-SRHEP-LSSCS------- -----S-DA----------TVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQIYLPQPALCPDSVYK-LMLSCWRRETKHRPSFQEIHLLLLQQGAE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >B_taurus_ENSBTAP00000006422 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--IPIPRMPL-----VLLLLLPIL---SSAKAQ-----VNPAVCRYPLG MSGGHIPDEDITASSQWSESTAARYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYSAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEANEWEPN AVSFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPVAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPVQPS--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITEDPLCMITEY-MENGDLNQFL-SRHEP-PNSSS------- -----A-SV---------PTVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKHRPSFQEIHLLLLQQVDD- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >C_familiaris_ENSCAFP00000019449 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--GLLPNKRINQDSALCYIICQIL---DQKIVS-----LGPAICRYPLG MSGGHIPDEDITASSQWSESTAAKYGRLDSEDGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WLADG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA PSGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEANEWEPN AVSFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPVAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPAQPS--GPEGAPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRHEP-PSSAS------- -----G-NV---------PTVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQIYLPQPVICPDSVYK-LMLSCWRRDTKHRPSFQEIHLLLLQQGDE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_cuniculus_ENSOCUP00000011647 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIENWPSLHTLN-----AVDMELYTGLQ KL--TIRNSGLRSIQPRAFAKNPHLRYI-------NLSSNR-LTTLSWQLFQTLSLRE-- -LRLERNFFNCSCDIRWMQLWQEQGEA-RLNSQDLYCVGAD------------------- ------------------------------------------------------------ -------GTQLPLFRMNIS----QC---DL--PEISV-SH-VNLTVREGDN-A------- -----------------------------------------------------VVTCNGS GSPLPDVD-------WIVTG-----LQS--INTH-------QTNLNWTNVHAINLTLVNV TSEDNG---FTLTCIAENVVGMS-NASVALSVH------------YPPRVVSLEEPEL-- -RLE-HCIEFVVRGNPPPTLH-WLHNGQPLRESKIIHVD-----YYQEG-----EVSEGC LLFNKPTHYNNGNYTLIAKNLLGTANQTISGH---------------------------- ------------------------------------------------------------ ------------FLKE-PFP-XXXXX---------------------------------- ------------XXXXAADVSPTPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVVLFVMINKYGR---------RSKF GMK---------------------------DPVAV-------------TN---YRIT--M PSLLNTGSD-------------------TVVI---------GMTHIL------------- --------------------------------VIENSPSQSHQRHN-------------- ------YRKPGT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >E_caballus_ENSECAP00000019400 ------------------------------------------------------------ ------------------------------------------------------------ ----------VCGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPLCEKTTINN----EYNYRCWTTNRCQKMCPSACGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYFYA----GVC-VPTCPPNTYRFEGWRCVDRDFCAN-IPSAE--- -------GSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRQILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTWKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSY-LYRHNYCSKD-K----- -IPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVMQIANTTMSSR -------SRNTTMADTY-----NVTDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------IE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVPAKT--TYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKDEMESG FREVSFYYSEENKPPEPEELDL----EP--ENMESVPLDPSASSSSLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >O_latipes_ENSORLP00000023219 ------------------------------------------------------------ -------------------------------------LRKYSLMNPLVCVHAVVISSVCL CVSLMQLK--IC-SSIHIRNDVTNFQLLENCTVIEGHLKILLMF-----QTRSEDFRGLS FPKLQVVTDYVLLFRVYGLETLSDLFPNLTVIRGNNLFFNYGLVIFEMRDLKEMGLYSLM NITRGSVRIEENSDLCYLSTLDWSKILDSVEDNFIVGNKDE-RECGDLCPGTAE------ -GRTICPQTTING----QYKARCWSQKHCQRTCLDKCKHGACNSRGQCCHDQ-CLGSCRE PGNA---SSCVACRNLQHG----NTC-VDKCPPGYFVFRGWRCVSFSFCQE-LHDQCSLT KKQNQDREASCVEYVIHEGAC-------IPE--CPSGYTTLN-----ST----MLTCLPC AGPCPKLC----VGNKTIDS-----VTS--AQAL-------RGC-----TVLHGNMIIKI R--GG-N---NIAAELESSLGQIEVITGYLMVR------RAYALVSLSFLRKLRIIKGEH LEGD-TYAFYALDNQNLRELWDWSKHNLTIENGRIFFHYNSKLCMSEIRRMEEITGAKER NQKNDIAVRTNGDQASCETKLLNFTQIKTSFK---------------------------- ------------------------------------------------MIILRWDAFWP- SDFRDLLGFMVLYKEA-PYK--NVTEFDGQDACGSNSWMIADVDPPPRPTPG-KEPEQPR HL---IGPLKPWTQYAIMVKTQ-LSASDE--HQVH------GAKSEIIYVRTNSTKPSAP LDPVSSSKSSSEISLKWKPPTSPNGNITHYKVIYRRQLEDSD-LFKFDYCLQGEH----- -LPREF----QQTKTLRMSRSGTT-QMSPPQGCCAC----PKTDSQLKKEQ-EEIEFRKT FENYLHNEVFE------------S----------RP------SRRRRS-VGVANATD--- ---PPLLMSTMSSIEAN----ATTVLPD------DE---DSSKVELKV--VSK-ESIV-- -IGNLHYFTSYKIEIIACNHPTD-----------PEGCSLANFRSERT------------ --------MPEEKADNIPGQ--VTHEIVMTEPPYVLIKWNAPPAPNGLIILYEVFYRRV- -------EEKEE--QTLCVSRPAYLKTNGTKLPLVQPGNYSVRVRATSLAGNGSFTETIY FFMPH----SNPGLVWIVSG-----PVICFILLLFVGAGVFV-VI-K--------KRQIE GPL--------------------------------------------------------- ----------------------------GDLI---------------------------- --------------------------------TSPN-PEYFSAND--------------- ------MYVPDE--WEVPREKITLLRELGQGSFGMVYQG-IAKDIV-------------- KGDPETRVAVKT---------VNESASLRERIEFLNEASVMK-----AFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTHGDLKSYL-RSLRP-DSE--------- ---NNPSGA---------PPPSLKDMLQMAAEIADGMAYLNAKKFVHRDLAARNCMVGED YTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--FLDRPDNCPERMHS-LMQMCWQYNPKMRPTFLEIIDMLRDDLHPT FHEVSFFHSEDNKVPETEEFDL----DL--DNMESIPLDP---SSYSQR----------- --------------------------EESL----SRDG--VP-------SVALRGNYEE- HVPYTHMNGGKKNGRIL------------------------------------------- ------LL--PRSSPS---- >H_sapiens_ENSP00000268035 ------------------------------------------------------------ -------------------------------------MKSGSGGGSPTSLWGLLFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYYYA----GVC-VPACPPNTYRFEGWRCVDRDFCAN-ILSAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTSKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGY-LYRHNYCSKD-K----- -IPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVMQVANTTMSSR -------SRNTTAADTY-----NITDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVQAKT--GYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKEEMEPG FREVSFYYSEENKLPEPEELDL----EP--ENMESVPLDPSASSSSLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >M_mulatta_ENSMMUP00000016141 ------------------------------------------------------------ -------------------------------------MKSGSGEGSPTSLWGLLFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSACGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYYYA----GVC-VPACPPNTYRFEGWRCVDRDFCAN-ILSAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTWKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGY-LYRHNYCSKD-K----- -IPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVMQVANTTMSSR -------SRNTTVADTY-----NITDL-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVQAKT--GYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKDEMEPG FREVSFYYSEENKLPEPEELDL----EP--ENMESVPLDPSASSSSLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >A_carolinensis_ENSACAP00000008063 ------------------------------------------------------------ -------------------------------------MKSGAGGGSLTLYGGLLVILTTF CFGPANGK--ICGPNIDLRNSIEQLKELEDCTVVEGYLRILLIN-------QGEDFSNIR FPKLTMITDYLLLFRVAGLETLSDLFPNLTVIRGRNLFYNYALVIFEMANLKEIGLYNLR NITRGAIRIEKNSDLCYLSTIDWSLILDAVSNNYIVGNKPA-KECGDLCPGTAE------ -QNPLCEKTSINN----EYSYRCWTSNHCQKKCPRSCGKYACTEQNECCHPE-CLGSCTV PNNN---TACVACRNYYHD----GAC-VPTCPPNTYKFEGWRCITKENCSR-ILLSPE-- -------SLEYESFVIHEDEC-------VQE--CPSGFIRND-----TQ----SMFCSPC EGPCPKVC-A-DEKTITIDS-----VTS--AQSL-------KGC-----TEIKGNLLINI R--RG-N---NIASELENFMGLIETVTGYVKIR------HSHALVSLSFLKNLRYINGED QLEG-NYSFYVLDNQNLQQLWDWSHHNLTVKEGKMYFAFNPRLCVSEIYRMEEVTGTKDR QNKGDINPRNNGDRASCESHILKFVSNTTMKN---------------------------- ------------------------------------------------RIKLTWEQYRP- KDYRDLISFTVYYKEA-PFQ--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKEDNPG IL---LQALKPWTQYAIYVKAVTLTMMEN--NHVH------GAKSEIVYIRTKAAVPSIP LDVISASNSSSQLIVKWNPPTYPNGNLSYYIVRWQQQPQDNY-LYRHSYCSKE-R----- -VPIRRYADGTIDTEEATEPTKPEGSGGEKGPCCGC----PKTEAEKQAEK-EEAEYRKV FENFLHNAIFL------------P----------RP------DRKRRDLFRIANTTFASK -------NRTAAAPEHV----TNASDA-------EESEMEFPFSERKV--EGR-ERTL-- -ISHLLPFTLYRIDIHSCNHEAA-----------LLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEG--KEENTIFLKWREPVSPNGLILMYEIKY-KQ- -------SE-EK--G-LCVSRQEYKKLGGAKLTNLNPGNVTVRVQATSLAGNGSWTEPIS FYVQPKPV-NYGNFLHLIIA----LPIAVLLIVGGLLIMLYV-CNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------VYVPDE--WEVPREKITMCRELGQGSFGMVYEG-IAKGVV-------------- KDEPETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-DTEVS------- ---NNP-AH---------TLPALKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDELDPA FKEVSFFYSDENKPPDTEELDL----EA--ENMESIPLDP---SSTLQP----------- ---------------------------SDKHSGHKAEN--GP------GVVVLRASFEE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >M_musculus_ENSMUSP00000005671 ------------------------------------------------------------ -------------------------------------MKSGSGGGSPTSLWGLVFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGFLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPP-KECGDLCPGTLE------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPE-CLGSCHT PDDN---TTCVACRHYYYK----GVC-VPACPPGTYRFEGWRCVDRDFCAN-IPNAE--- -------SSDSDGFVIHDDEC-------MQE--CPSGFIRNS-----TQ----SMYCIPC EGPCPKVCGDEEKKTKTIDS-----VTS--AQML-------QGC-----TILKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLRFTSTTTWKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKEGEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGY-LYRHNYCSKD-K----- -IPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERRRRDVMQVANTTMSSR -------SRNTTVADTY-----NITDP-------EEFETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVPAKT--TYENFMHLIIA----LPVAILLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMNRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EVEQ-------- ---NNL-VL---------IPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDEMEPS FQEVSFYYSEENKPPEPEELEM----EP--ENMESVPLDPSASSASLPL----------- ---------------------------PERHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRANERAL------------------------------------------- ------PL--PQSSTC---- >R_norvegicus_ENSRNOP00000019267 ------------------------------------------------------------ -------------------------------------MKSGSGGGSPTSLWGLVFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGFLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPP-KECGDLCPGTLE------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPE-CLGSCHT PDDN---TTCVACRHYYYK----GVC-VPACPPGTYRFEGWRCVDRDFCAN-IPNAE--- -------SSDSDGFVIHDGEC-------MQE--CPSGFIRNS-----TQ----SMYCIPC EGPCPKVCGDEEKKTKTIDS-----VTS--AQML-------QGC-----TILKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLRFTSTTTWKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKEGEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGY-LFRHNYCSKD-K----- -IPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERRRRDVLQVANTTMSSR -------SRNTTVADTY-----NITDP-------EEFETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVPAKT--TYENFMHLIIA----LPVAILLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMNRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EVEQ-------- ---NNL-VL---------IPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDEMEPS FQEVSFYYSEENKPPEPEELEMELELEP--ENMESVPLDPSASSASLPL----------- ---------------------------PERHSGHKAEN--GP------GVLVLRASFDE- RQPYAHMNGGRANERAL------------------------------------------- ------PL--PQSSTC---- >P_troglodytes_ENSPTRP00000012792 ------------------------------------------------------------ -------------------------------------MKSGSGGGSPTSLWGLLFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYYYA----GVC-VPACPPNTYRFEGWRCVDRDFCAN-ILSAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTSKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGY-LYRHNYCSKD-K----- -IPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVMQVANTTMSSR -------SRNTTAADTY-----NITDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVQAKT--GYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKEEMEPG FREVSFYYSEENKLPEPEELDL----EP--ENMESVPLDPSA---SLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >M_domestica_ENSMODP00000001377 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--TPFSKLPL-----VLLLLPPIL---SVTKAQ-----VNPAVCRYPLG TSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLRNLH FITLVGTQGRHAGGHGNEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIVLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA INGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VHCYF-RSESNEWEPN AVSFLPVLDDVNPSARFVTVPLLHRMASAIK----------------------------- ------------------------------------------------------------ -CQFHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSSVAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNH---SSSP--S EQESNSTYD-RIFPLG-PDYQEP-----SRLIRKLPEFAP---GDEE------------- -----------------AGCSGVVKPVQPN--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFMDKDF---ALDV NTNQPALVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCIAEDPLCMITEY-MENGDLNQFL-SRHEP-QSPPS------- -----S-NA---------PTVSYINLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDPVYK-LMLSCWRRDTKNRPSFQEIHLLLLQQGNG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_aculeatus_ENSGACP00000019077 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--KHPWDAHF-----LLLILLHLF---GGVTSQ-----VNPGVCRYPLG MSGGQIQDEDISASSQWSESTAARYGRLDFEEGDGAWCPEVTVEPDSQKEFLQIDLRSLH FVTLVGTQGRHAGGIGNEFSQMYKIKYSRDGSRWISWRNRQ------------------- ------------------------------------------------------------ -------GQQVIEGNRNAY----DIVLKDLEPPIIAR-FVRFMPVTDHPMN-V------- -----------------------------------------------------CMRVELY G-----CE-------WL-DG-----LVSYNAPAG-------EQM-----SLP-A---YFN DSVYDG---AVIH-SMTEGLGQLTDGVCGLDDF-----SHSHVYNVWPGYDYVGWTNESF PAGF-VEIMFEFDRTRNFTTM-KVHCNNMFSQHTKAFRQ-----VVCYF-RSEA-DWEPT PLVFNPGEDEQNPRARFVTIDLLHHMASAIK----------------------------- ------------------------------------------------------------ -CRFYFADAWMLFSEI-TFQ--SD------------------------------------ -----TAMYNTTLAPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KSGLPPNIQPEDDPTHKV---------- ---DDS-------NTRILIG----CLVAIIFILVVIIVIILWRQVWQKIVE----KASRR MLD---------------------------DELTASLSIQSETLAYTHNQ---ASTS--S EQESNSTYE-RIFPLV-PDYQEP-----SHIMCKLPEEPA---S---------------- ------------------SSTAASKATTTT-IVQEGAPHYAEADIVDLQGVTGSNTYAIP TLVMDLLSGKDIGVEEFPRKLLTFKEKLGEGQFGEVHLC-EAKGMQEFMNTEF---SFDI PEEQTVLVAVKM---------LRSDADKNARLDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCIYSDPLCMITEY-MENGDLNQFL-SHHEP-EGQLA------- ---LLS-NA---------PTVSFNDLSYMAAHIASGMKYLSSLNFVHRDLATRNCLVGKN FTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDKKRQIYLPQPELCPDSLYW-IMLSCWRRNTKERPSFQEIHRALLEM---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_gallus_ENSGALP00000011384 ------------------------------------------------------------ -------------------------------------MKSGAGGGTLAVFCGLLLAFAAL CL-GTNGE--ICGPNVDIRNDIHELKRLENCTVVEGFLQILLIS-------KAEDYRNFR FPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGRNLFYNYALVIFEMTNLKEIGLHNLR NITRGAIRIEKNSDLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPLCEKTSINN----EYNYRCWTTNHCQKMCPSSCGKRACTDQNECCHPE-CLGSCTA PDNN---TACVACRNYYYE----GVC-MPTCPPNTYKFEGWRCVTKEFCSK-VPATE--- -------TSDYERFVIHNDEC-------MAE--CPSGFIRNG-----SQ----SMFCSPC EGPCPKIC-E-DGKTKTIDS-----VTS--AQML-------QGC-----TILKGNLLINI R--RG-N---NIASELENFMGLIETVTGYVKIR------HSHALVSLSFLKNLRYILGEE QVDG-NYSFYVLDNHNLQQLWDWNHHNLTIKEGKMYFAFNPKLCVSEIYRMEEVSGTKGR QSKGDINPRNNGERASCESHILRFVSNTTLKN---------------------------- ------------------------------------------------RIKLTWERYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKENDPG IL---LQGLKPWTQYAIYVKAVTLTMMEN--HHIH------GAKSEIVYIRTNAAVPSIP LDVISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQQQPQDSY-LYRHNYCSKD-K----- -VPIRRYADGTIDTEEATEPTKPEGCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------DRKRRDVFRIANATLATR -------NRNITGADHF----TNASDA-------EESEVEYPFFETKV--DGK-ERTV-- -ISHLQPFTLYRIDIHSCNHEAD-----------TLGCSASNFVFART------------ --------MPSEGADNIPGT--VAWEA--KEENTVYLKWLEPTNPNGLILMYEIKYGQH- -------GE-EK--R-ECVSRQEYKKLGGAKLTHLNPGNYSARVQATSLAGNGSWTEPVS FYVQPKSA-NYDNFLHLIIV----LPIAFLLIIGGLLIMLYV-FNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------VYVPDE--WEVPREKITMCRELGQGSFGMVYEG-IAKGVV-------------- KDEPETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-DTE--------- ---SNP-GQ---------APPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMTNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKDELDPA FKEVSFFYSEENKPPDTEELDL----ET--ENMESIPLDP---SSTLQP----------- ---------------------------TDKHSGHKAEN--GP------GVVVLRASFEE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >B_taurus_ENSBTAP00000028690 ------------------------------------------------------------ ------------------------------------------------------------ ----------MLNPAHLARN---------AEYLLPAPAKF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STCNTVCPSACGKRACTETHECCHPE-CLGSCSA PDNA---TACVACRHYYYA----GVC-VPSCPPNTYRFEGWRCVDRDFCAN-IPNAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRQILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTSKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSY-LYRHNYCSKD-K----- -IPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNAIFV------------P----------RP------ERKRREVMQIANTTMSSR -------SRNTTVLDTY-----NITDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVQAKT--TYENFIHLMIA----LPIAVLLIVGGLVIMLYV-FHRK--------RNSSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSVKDEMEAG FREVSFYYSEENKPPEPEELDL----EP--ENMESVPLDPSASSASLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >C_familiaris_ENSCAFP00000016006 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RLGSREMLHAHLFV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PSAPTVCPSACGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYYYA----GVC-VPTCPPNTYRFEGWRCVDRDFCAN-IPSAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRQILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTWKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSY-LYRHNYCSKD-K----- -IPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVTQVTNTTMSSR -------SRNTTVVDTY-----NITDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASNFVFART------------ --------MPAEGADDIPGP--VTWES--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------IE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVPAKI--TYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRR--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EIEQ-------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKDEMEPG FREVSFYYSEENKPPEPEELDL----EP--ENMESVPLDPSASSSSLPL----------- ---------------------------PDRLSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >P_troglodytes_ENSPTRP00000002684 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--ILIPRMLL-----VLFLLLPIL---SSAKAQ-----VNPAICRYPLG MSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEASEWEPN AISFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSEALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPMAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSDSSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPVQPS--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIHLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRHEP-PNSSS------- -----S-DV---------RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKNRPSFQEIHLLLLQQGDE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >P_pygmaeus_ENSPPYP00000007720 ------------------------------------------------------------ -------------------------------------MKSGSGGGSPTSLWGLLFLSAAL SLWPTSGE--ICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS-------KAEDYRSYR FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPMCEKTTINN----EYNYRCWTTNRCQKMCPSACGKRACTENNECCHPE-CLGSCSA PDND---TACVACRHYYYA----GVC-VPACPPNTYRFEGWRCVDRDFCAN-ILSAE--- -------SSDSEGFVIHDGEC-------MQE--CPSGFIRNG-----SQ----SMYCIPC EGPCPKVC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TIFKGNLLINI R--RG-N---NIASELENFMGLIEVVTGYVKIR------HSHALVSLSFLKNLRLILGEE QLEG-NYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR QSKGDINTRNNGERASCESDVLHFTSTTTSKN---------------------------- ------------------------------------------------RIIITWHRYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVEPG IL---LHGLKPWTQYAVYVKAVTLTMVEN--DHIR------GAKSEILYIRTNASVPSIP LDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGY-LYRHNYCSKD-K----- -IPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERKRRDVMQVANTTMSSR -------SRNTTAADTY-----NITDP-------EELETEYPFFESRV--DNK-ERTV-- -ISNLRPFTLYRIDIHSCNHEAE-----------KLGCSASKFVFART------------ --------MPAEGADDIPGP--VTWEP--RPENSIFLKWPEPENPNGLILMYEIKYGSQ- -------VE-DQ--R-ECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVF FYVQAKT--GYENFIHLIIA----LPVAVLLIVGGLVIMLYV-FHRK--------RNNSR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVAREKITMSRELGQGSFGMVYEG-VAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EME--------- ---NNP-VL---------APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPAFLEIISSIKDEMEPG FREVSFYYSEENKLPEPEELDL----EP--ENMESVPLDPSASSSSLPL----------- ---------------------------PDRHSGHKAENGPGP------GVLVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSTC---- >H_sapiens_ENSP00000356899 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--ILIPRMLL-----VLFLLLPIL---SSAKAQ-----VNPAICRYPLG MSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEASEWEPN AISFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSEALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPMAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSDSSMFNNNR---SSSP--S EQGSNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPVQPS--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIHLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRHEP-PNSSS------- -----S-DV---------RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKNRPSFQEIHLLLLQQGDE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >T_guttata_ENSTGUP00000008956 ------------------------------------------------------------ -------------------------------------MKSGAGGGSLAVVWGFLLVFAAL CLWPTNGE--ICGPNVDIRNDIHELKRLENCTVIEGFLQILLIS-------KAEDYRNFR FPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGRNLFYNYALVIFEMTNLKEIGLHNLR NITRGAIRIEKNSDLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTME------ -EKPLCEKTSINN----EYNYRCWTTNHCQKMCPSSCGKRACTDQNECCHPE-CLGSCTA PDNN---TACVACRNYYYE----GVC-LPTCPPNTYKFEGWRCVTREFCSK-VPATD--- -------ASEYEKFVIHNDEC-------MAE--CPSGFIRNG-----SQ----SMFCSPC EGPCPKIC-E-DGKTKTIDS-----VTS--AQML-------QGC-----TILKGNLLINI R--RG-N---NIASELENFMGLIETVTGYVKIR------HSHALVSLSFLKNLRYILGEE QVDG-NYSFYVLDNHNLQQLWDWNHHNLTISEGKMYFAFNPKLCVSEIYRMEEVSGTKGR QSKGDINPRNNGERASCESKILHFVSNTTLKN---------------------------- ------------------------------------------------RIKLTWERYRP- PDYRDLISFTVYYKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKENNPG IL---LQGLKPWTQYAIYVKAVTLTMMEN--HHIH------GAKSEIIYIRTNAAVPSIP LDVISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQQQPQDSY-LYRHNYCSKD-K----- -VPIRRYADGTIDTEEATEPTKPEGCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------DRKRRDVFRIANATLATR -------SRNATGTDHF----TNASDT-------EESEVEYPFFETKV--DGK-ERTV-- -ISHLQPFTLYRIDIHSCNHEAD-----------TLGCSASNFVFART------------ --------MPSEGADNIPGT--VSWEA--KEENTVYLKWLEPANPNGLILMYEIKYGQH- -------GE-EK--R-ECVSRQEYKKLGGAKLTHLNPGNYSARVQATSLAGNGSWTEPIS FYVQPKSA-NYGNFLHLVIV----LPIVLLFILGALLVMLYV-VNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------VYVPDE--WEVPREKITMCRELGQGSFGMVYEG-IAKGVV-------------- KDEPETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-DTE--------- ---NNP-GQ---------APPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMTNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDELDPA FKEVSFFYSEENKPPDTEELDL----ET--ENMESIPLDP---SSTLQP----------- ---------------------------TDKHSGHKAEN--GP------GVVVLRASFEE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >T_rubripes_ENSTRUP00000039547 ------------------------------------------------------------ -------------------------------------MRSRMERSHLTLFWGLMLGLSSC LRPAAAE---ICGPSIDIGNDISEFRRLENCTVVEGYLQILLIGDKNN-NINQEIFRSLS FPKLTMITDFLLLFRVSGLDSLSTLFPNLTVIRGRNLFYNYALVIFEMTSLKDIGLYSLR NITRGAIRIEKNPELCYLDSVDWSVIMDAEFNNYIAGNKQS-KECSDVCPGIME------ -SSPQCRKTMFND----NYNYRCWNSNHCQKECPEKCGQRDCTVDGECCHPQ-CLGSCTL PGSD---TACAACVHYYHQ----GRC-VAECPPGTYKFEGWRCVSVEFCSK-VH------ -------LPDPHTFVIHGQEC-------MPE--CPSGYTRST-----TD----NMSCTAC DGLCDKVC---EGEEKVIDS-----VDA--AQSL-------KGC-----TVIKGNLHINI R--RG-H---NMVAELESFTGLIQRVKGYVRIR------HSHTLNSLAFLRSLRYIDGEN LLDD-MYAFSAFDNHQLQYLWDWSQHNLTIKTGKLFFRANPKLCMSEIHKMWEKTGIQGR FDESDF--RNNGDRASCESTILAFTSNSTSST---------------------------- ------------------------------------------------RIKLTWQRYRP- PDYRDLISFIVYFKEA-PYQ--NITEYEGQDGCGSNSWNMVDVELR-----Q-DRDSDPG VL---LSGLKPWTQYAVFVKAITL-VVEN--KHVP------SAKSKVVYIRTRPSAPSMP QDVRAYSNSSTQLVVRWSPPVSANGNQTYYLVRWQQQAEDRE-LYQHNYCSKELK----- -LPIRIAATGVGDQEEDTKPTKPDADGPEKGPCCPC----PKSVEDLEAEA-ADASYRKV FENFLHNSIFT------------P----------RP-----PDRRRRDVFGVANSTHWPH NRLPIN-NSTVSSVQAG----SNSSSSSNSGDNVEPVDREFEFTEQSV---TE-RELQ-- -ISGLKPFTVYRIDIHACNRQVQ-------------RCSAAEFVFSRT------------ --------KPAEKADDIPGT--VTWEG---HEDWGFLRWPEPHHPNGLVLMYEIKFKLA- -------SE-SE--KHECVSGQMYQTQRGVRLSNLSPGNYSVRVRAISLAGNGSWTHILD LYVAESKP-RRNVCFVDMIF----IPIAIVFFICLLVTMLVV-LNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAE--------------- ------MYVPDE--WEVAREKICLSRELGQGSFGMVYEG-LAKGVV-------------- KDEPETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-KEQ--------- ---QWS-SL---------SLPPLKKMLQMAGQIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPQNCPDMLFE-LMRMCWQYNPKMRPSFVEIISSIKDELEPS FSEVSFFYSADNKPAEAPQPHI----DK-LDNVDDILLDTPSSSSSVQPQQTPVSQQTPP SPSSETPPAPSRAASSPSSPCTSTAAVDKQPSSQQAAN--GL--SGAGSDASARPSLDD- LPPYAHMNGGRKNERAM------------------------------------------- ------PL--PQSSAC---- >E_caballus_ENSECAP00000008980 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--ILIPRMPL-----VLLLLLPIL---SSAKAQ-----VNPAICRYPLG MSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEANEWEPN AVSFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TLPVAPTT---YDPMLKV---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPVQPN--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRHEP-PSSSS------- -----S-NV---------PTVSYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKHRPSFQEIHLLLLQQVDE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_aculeatus_ENSGACP00000019455 ------------------------------------------------------------ -------------------------------------MRSQAERSRLTLFWGLMLGLSSC LRPATAE---ICGPSIDIGNDIIEFRRLENCTVVEGYLQILLIGDKNNKNVQQDDFSSLS FPKLTMITDYLLLFRVSGLDSLSTLFPNLAVIRGRNLFYNYALVIFEMTSLKDIGLHNLK NITRGAIRIEKNPELCYLDSIDWSLILDAEFNNYIAGNKQS-KECSDVCPGIME------ -NNPQCRKTMFNN----NYNYRCWNSNYCQKECPEKCARQACTADGECCHPQ-CLGSCTA PESD---TACAACAHYYHQ----GRC-VADCPRDTYKFEGWRCISKEVCSK-VH------ -------LPDFNSFVIHGGEC-------MSE--CPHGYMQAT-----PN----SMFCKAC DGLCDKVC-----EEKVIDS-----VDA--AQSL-------KGC-----TVIKGNLHINI R--RG-H---NMVAELESFTGLIQRVTGNVRIR------HSHTLSSLAFLRNLRHIDGDN LLDD-MYAFVAVDNQQLQYLWDWKQHNLTIKAGKLSFRANPKLCMSEIRDMWNKTGIQGS FDESDF--RNNGDRASCESTILTFKSNTTSST---------------------------- ------------------------------------------------RIKLTWQRYRP- PDYRDLISFIVYYKEA-PFQ--NITEFEGQDGCGSNSWNMVDVELR-----P-DKDSDPG VL---LSNLKPWTQYAVFVKAITL-MVED--KHLP------SAKSKVVYIRTSPSAPSMP QDVRAYSNSTTQLVVRWSPPISPNGNQTYYLVRWQQQAEDRE-LYQHNYCSKELK----- -IPIRIAAIGVGDQEEETKPTKAD-DGPDKGPCCLC----PKSVEDLEAEA-ADASYRKV FENFLHNSIFT------------P----------RP-----PDRRRRDLFAVANSTQPRR TRLHGN-SSTAPPQQAA----GNGSAAADV----GPADIEFDFVEQAV---EE-RELQ-- -ISGLQPFTVYRIDIHACSRQVQ-------------RCSAAEFVFSRT------------ --------RPAEKADDIPGP--VTWDG---HEDWVFLRWSEPPHPNGLILMYEIKFKLA- -------AE-NE--KHECVSGQTYRDQRGVRLSNLGPGNYSVRVRATSLAGNGSWTHTLD LYVAER----YENMLYTMIF----VPILIVLF-CLLVPLLVV-LSRK--------RSSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAE--------------- ------MYVPDE--WEVAREKITLNRELGQGSFGMVYEG-LAKGVV-------------- KDEAETRVAIKT---------VNESASMRGRIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-KEQ--------- ---QWS-SL---------SLPPLKKMLQMAGQIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTTSDVWSFGVVLWEIATLSE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPQNCPDMLFE-LMRMCWQYNPKMRPAFVEIISSLKDELDPS FRELSFFYSADNKPPEAAHHHA----EQ-MEDVDTVPLDP--ASPKRQP--TPAPQQTPP SPGSEAPPAPSLAPSSPSSPGTSSAATDKQPSGQPAAN--GL-------------SLDE- LPPYTHMNGGRKNERAM------------------------------------------- ------PL--PQSSAC---- >D_rerio_ENSDARP00000076054 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RYFCFQPMVRVHRR-----------SIWQVPPNLKEFLQIDLRTLH FVTLVGTQGRHADGVGNEFAQRYRIKYSRDGTRWVSWRDRQ------------------- ------------------------------------------------------------ -------GRQIIEGNSNAY----DIVLKDLEPPIIAR-FVRFMPVTDPSMI-V------- -----------------------------------------------------CMRVELY G-----CE-------WL-DG-----LVSYSAPAG-------QQM-----TFR-GQQIYLN DTVYDG---AVSS-SMAEGLGQLTDGSWGLDDF-----TKSQVYGVWPGYDYVGWTNASL PGGS-VEMTFEFDRVRNFTSM-KVHCNNMYAWGVKMFRQ-----AVCSF-RSDA-DWEPN PVFFKPKADSISPSARFITVALGNRMASAIR----------------------------- ------------------------------------------------------------ -CRFAFSDIWMMFSEI-AFQ--SA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NRSV---DDPTHKI---------- ---DDS-------STRILIG----CLVAIIAILLAIIIIILWRQVWQKMIE----KASRR MLD---------------------------DELAVRLSVQREAFVHRS-----SSLS--S DVESTSTYE-RIFPLG-SDYQEP-----SQLLRKLPEFQA---MENL------------- -----------------AMIDGASEPSPAQ--GTDEAPHYAEADI------PGAHSYRVT VVNMPLSPGRDGALEEFPRDRLTFKEKLGEGQFGEVHLC-EAEGMQEFMKD-----HCDD ICVDPMLVAVKT---------LREDADKNARNDFMKEIRIIS-----RLRDPNIIRLL-- ---------------AVCVESDPLCMITEY-MENGDLNQFL-SRHQL-QEDG-------- ---VQA-DS---------TSISYGTLINMASQISSGMKYLSSLNFVHRDLATRNCLVGMN NIIKIA-DFGMSRNLYRGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYAQFTDE Q----------------------------------------------------------V IENTGEFFRDQNKQVYLLRPACCPESLYS-LMLNCWRRNAKERPTFLEIHSTLTEQH--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------D >M_mulatta_ENSMMUP00000012220 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--ILIPRMLL-----VLFLLLPIL---SSAKAQ-----VNPAICRYPLG MSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLH FITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIFLKDLEPPIVAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CMRVELY G-----CV-------WL-DG-----LVSYNAPAG-------QQF-----VLPGGSIIYLN DSVYDG---AVGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNESA TNGY-IEIMFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSEASEWEPN AISFPLVLDDVNPSARFVTVPLHHRMASAIK----------------------------- ------------------------------------------------------------ -CQYHFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGALP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TSPMTPTT---YDPMLKI---------- ---DDS-------NTRILIG----CLVAIIFILLAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSDSSMFNNNR---SSSP--S EQESNSTYD-RIFPLR-PDYQEP-----SRLIRKLPEFAP---GEEE------------- -----------------SGCSGVVKPVQPS--GPEGVPHYAEADIVNLQGVTGGNTYSVP AVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFKDKDF---ALDV SANQPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIHLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRHEP-PNSSS------- -----S-NV---------PTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPAICPDSVYK-LMLSCWRRDTKNRPSFQEIHLLLLQQGDE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >D_rerio_ENSDARP00000023951 ------------------------------------------------------------ ------------------------------------------------------------ ----------------DIRNNVTNLRVLENCTVIEGHLKILLMF-----TTKPEDFRGLS YPKLTVVTDYLLLFRVYGLESLSDLFPNLTVVRGNNLFFNYALVLFEMLQLKEIGLHSLM NITRGAVRVEKNPDLCYLSTLDWSMILDSVEDNYIVANKND-RECGDICPGTVL------ -GKTTCPLTTING----DFSERCWNQKYCQRMCPSSCKHRACTKDSQCCHDQ-CLGGCLE PHSS---NKCVACRNFMHN----NMC-VEKCPHGFYTFKGWRCVSFSFCQE-LHNKCK-- -----QGKGDCHEYVIHNGAC-------IPE--CPSGYTTVN-----ST----TLNCTPC AGLCPKVC----MGLKTVDS-----VTA--AQAL-------RGC-----TVINGSLVINI R--GG-N---NIAAELEANLGQLEEITGYLTVR------HSYALVSLSFLRKLRIIHGET QEVG-NYSFYALDNQNLRQLWDWSKHNLTIQQGRMFFHHNSKLCMSEIRRMEEVTGTKNR QTKNDIVSKTNGDQASCESKVLKFTRISTLSD---------------------------- ------------------------------------------------KIIIKWEAFWP- PDFRDLLGFMVLYKEA-PYK--NVTEFDGQDACGSNSWVIADVDPPPRATEG-K-EHEPG YL---IFPLKPWTQYAIMVKTQ-LSASDE--HQVH------GAKSEIIYVRTNATKPSVP LDPISSSNSSSQIILKWKPPNDPNGNITHYLVFCQQQPEASE-LYKFDYCQKGMK----- -LPTRA-PT-QVDNEEEQKWNQTE-EQGPDSRCCAC----PKTEKQLKKEA-EETEYRKT FENYLHNEVFE------------L----------RM-----PSRQRRSLVGIANRTS--- ---SRL-FTTPSSLPNG----SATRSP--------EEEAEANKISLIV--QAK-ESTV-- -ISNLRHFTSYQIEIHACNHGSD-----------PTRCSMAAYVSART------------ --------MPEEKADDIVGK--ITCEV---FEYSVHIRWIEPKAPNGMIILYEVHYKRL- -------GDTEE--LHHCVSRKNYIADGGCKLRVVHPGNYTVRIRATSLAGNGSWTEPTH FYVQDLRV-DPSNVLKIVIG-----PVICFFLLLLLCV-GFY-IV-K--------KKQTE GPT--------------------------------------------------------- ----------------------------GRLY---------------------------- --------------------------------TSPN-PEYFSPDE--------------- ------VYEPDE--WEVPREKITLLRELGQGSFGMVYEG-NGKDIV-------------- KGESQTRVAVKT---------VNESASLRERIEFLNEASVMK-----AFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTHGDLKSFL-RSLRP-DSE--------- ---NNP-GR---------PPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAED LTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEVSTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MEGG--YLDRPDNCADRLHN-LMQMCWHYNPKMRPTFQEIIEMLREDLHPS FQEVSFFYSEENKPPETEEFDM----DL--ENMESIPLDP---SS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >G_gallus_ENSGALP00000004224 ------------------------------------------------------------ ------------------------------------------------------------ ----------MPALPRAALLL-----LLLLLLCIL---LAARAQ-----VNPAVCRYPLG MSGGHIPDEDISASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLRALH FITLVGTQGRHAGGHGNEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNSNPY----DIVLKDLEPPLIAR-FVRFIPVTDHSMN-V------- -----------------------------------------------------CLRVELY G-----CA-------WL-DG-----LVSYSAPAG-------QQL-----VLPSGTVIYLN DSVYDG---AFGY-SMTEGLGQLTDGVSGLDDF-----TQTHEYHVWPGYDYVGWRNEST AGGY-VEITFEFDRIRNFTTM-KVHCNNMFAKGVKIFKE-----VQCYF-RSDANEWEPN AISSVLVLDDVNPSARFVTVPLLHRMASAIK----------------------------- ------------------------------------------------------------ -CQYYFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSAVPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EMPMAPTT---YDPTLKM---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNHNR---SSSS--S EHESNSTYD-RIFPLG-PDYQEP-----SRLIRKLPEFTA---GEED------------- -----------------TGCSGLVKPSPAS--GPEGVPHYAEAEIVNLQGVTGGNTYSVP ALTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFADKEFTLEGLDA SPNCPVLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITDDPLCMITEYMMENGDLNQFL-SRHEA-QSPPD------- -----A-SV---------PTISYSDLRFMATQIASGMKYLSSLNFVHRDLATRNCLVGKR YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTLCREQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPKPALCPDSVYK-LMLSCWRRDTKDRPSFQDLHRQLQEAATEE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >X_tropicalis_ENSXETP00000010297 ------------------------------------------------------------ ------------------------------------------------------------ ----------M--RGKSQIPL-----ILPLFLLIL---SSVESQ-----VNPAVCRYPLG MSGGHIPDEDITASSQWSESTAAKYGRLDSEGGDGAWCPEMPVDPEELTEFLQIDLRVLH FITLVGTQGRHAGGHGNEFAQMFKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GRQVLDGNVNPY----DIVLKDLEPPIVAR-FLRFIPVTDHSMN-V------- -----------------------------------------------------CLRVELY G-----CV-------WL-DG-----LVSYNAPSG-------QQF-----LLPEGYAIYLN DTIYDG---AIGY-SMTEGLGQLTDGVSGLDDF-----TLTHEYHMWPGYDYVGWSNESF SNGY-VEIVFEFDRIRNFTTM-KVHCNNMFSKGVKIFKD-----VQCFF-RSDANEWEAN SISSTLVLDDANPSARYVTVQLHNHMARAIK----------------------------- ------------------------------------------------------------ -CHYYFADSWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSMNPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QPASVPTT---YDPTLKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQFWQKMLE----KASRR MLD---------------------------EELTVSLSLPSDSSMYNTNRRHDSVSA--S EQESNSTYD-RIFPLG-PDYQEP-----TRLIRKLPEFTAQTVGEEE------------- -----------------TAGSSAGKSALPA--SADGVPHYAEADIVNLQGVTGGNTYSVP AITMDLLSGKEVAVEEFPRKHLTFKEKLGEGQFGEVHLC-EAEGVEEFLDKDL---ILET SPGQPTLVAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCIAEDPLCMITEY-MENGDLNQFL-SRQQP-EGGLP------- -----A-AT---------LPISYTDLRHMAAQIASGMKYLSSLNFVHRDLATRNCLVGRN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFAVTLWETLTFCREQPYSEMSDE Q----------------------------------------------------------V IENTGEFFRDQGKQVYLPKPNICPERVYK-LMLSCWRRETKDRPSFQEICQSLQSESGL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >D_rerio_ENSDARP00000096601 ------------------------------------------------------------ ------------------------------------------------------------ ----------VC-PSTDIRNIATNLRVLENCTVIEGHLKILLMF-----KTTQEDFRGLS FPKLVMVTDYLLIFRVYGLESLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLT NITRGAVRIEKNPNLCYLSTLDWSKILDSVEDNYIVANKDD-LECGNICPGTIA------ -GTISCKQTTING----NFGERCWNQNHCQRICPSECVHGACTSHKECCHEQ-CLGGCSV PGNS---TKCVACRNFLYG----EAC-VDRCPPGYYTFKSWRCVSLQFCQD-LHNQCK-- -----DKSGDCHAYVIHNGAC-------IPE--CPSGYTTVN-----ST----SLTCMPC TGRCPKVC----TGVQTVDS-----VTA--AQAL-------RGC-----TVLNGSLIIKI S--GG-N---SIAAELESSLGQLEEITGYLTIR------RAYALVSLSFLRKLHLIRGET LDGG-NYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQATGTKNR --MNDIS--NEKDQSYCESHILKFTQIRTMSD---------------------------- ------------------------------------------------KILIRWESFWP- SDFRDLLGFMVLYKEA-PHR--NVTEYDGQDACGSNSWAIADVEPPQRPSEG-K-EVEPG YL---IMPLKPWTQYAVMVKAQ-LAASED--HQVR------GAKTEIIYVRTNATRPSVP LDPHSWSNSSSQIILKWKPPSDPNGNITHYIIYCQKQSEDIT-HYKFDYCQQGMK----- -VPSHT-PT-HHDVEEDQKLNQTE-VPDQKGHCCAC----PKTEMQLKKEA-EETEFRKT FENYLHNEVFE------------P----------RP------HRRRRS-VGVANATL--- ---PNF-GTTPTIIPNF----PTTSIP-E-----EE---KSRKMVFKA--SSK-EAMV-- -ISNLLHFTSYQIEIHACNDPTD-----------PGRCSMPTYVKART------------ --------LPELKADVIAEP--VTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKYLRM- -------SDNYE--DQICVSRISYEKNHGYRLRVGHPGNYSVRVRATSLAGNGSWTDPAY FYVQDSKL-YWEMSMKIVII-----LAICIFLLVILASVGYF-VL-K--------KKQTE GPT--------------------------------------------------------- ----------------------------GPLI---------------------------- --------------------------------ASSN-PEYISAND--------------- ------VYIPDE--WEVPREKITVMRELGQGSFGMVYEG-IAKDII-------------- KGEPDTRVAVKT---------VNESASLRERIEFLNEASVMK-----AFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTHGDLKSYL-RSLRP-DAE--------- ---NNP-GS---------PPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLAARNCMVAED YTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDRPENCPERMHN-LMQMCWQYNPKMRPTFHEIIEMIKEDLHPT FQEVSFFYSEENKAPESEEFDM----DF--ENMESIPLDP---SS--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >A_carolinensis_ENSACAP00000005199 --------------------------------------------------MDVSFCPTKA RFWRLFWLWSLCGDYLASVWGCPANCLCNKTEIHCKKPD-DGNLFPLLEGQDAGTTNGNA SINITDISRNITSI------------------HIEYWRNLQTLH-----AVDMELYTGLQ RL--TIKNSGLRSIQPRAFDKNPHLRYI-------NLSGNR-LTTLSWLLFKTLRLIE-- -LRLERNIFNCSCDIRWIQLWQQKGEA-NLQYQELRCTSME------------------- ------------------------------------------------------------ -------TSHISIQEMNIS----QC---DL--PEISV-SH-VNLTVCEGEN-A------- -----------------------------------------------------VITCNGS GSPLPDVD-------WMVVN-----LRS--INTH-------QTNANWTNVHSINLTLVNV TSEDNG---FLLTCIAENVVGMS-NASVLLTVY------------YPPRIISLLEPIR-- -HME-HCIEFSVHGNPPPQIH-WLYNGQVLRETEFIRME-----LFQEG-----EVSDGC LLFNHPTHYNNGNYTIVASNYLGTVNQTVRGH---------------------------- ------------------------------------------------------------ ------------FLEK-PFP-SERLQ---------------------------------- -------------FYVFTVPSPSPL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ITVTHKP---------- ---EED-------TFGVSIA----VGLAAFACVLLVILFIMINKYGR---------RSKF GMK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------G >A_aegypti_AAEL002317-PA ------------------------------------------------------------ -------------------------------------MALSGQNMHNLG----------- ----------VC-GSVDVRNSPAHLDRLKDCVVVEGFVHILLID-----KYIDSSFENYS FPLLTEITEYLLLFRVNGLKSLRRLFPNLAVIRGDALVGDYAMVIYELMHIEEIGLISLM DITRGGVRIEKNPKLCFANTIDWKAMTVPGTNNYIKDNQKD-NVC-PICPAESTAVMLPN GSKQKCPAAPVRGGNKDHKRTLCWNANHCQTICPPECP-KACSKTGVCCDAESCLGGCNL PNT----SSCSVCRHLSIDPAGKRQC-VAKCPPNTFKYHT-RCVTRDECYA-MKKPIS-- --LDSNPDLPDQPFIPHNGSC-------LME--CPLDHELITEL---NK----TRWCRKC SGTCPKRC-----EGSNIDN-----IQS--AQLL-------KGC-----EIIDGSLEIQL RSRGG-E---NIVKELENFLSSITEIKGYLKVV------RSYPLLSLGFLKKLKIIHGKG NKVS-NSSLYVVENQNLQELFD---HNVTIGEGKLFFFNNPMLCTDRIKAVKKYNPGIEI ENESQLE-SNNGDRAACSITELETSLKSIGSE---------------------------- ------------------------------------------------TAIIQWAPFTEL SDARMLLGYVIYYIEA-PYA--NVTFFDGRDACNTEGWRLDDISD------F-NMDKETT KI---LTQLKPYTQYAYYVKTYTLG------SEGL------GGQSKIKYFTTAPGTPSVV RDV-EVSVNKNMLTVKWLPPLKMNGRLKEYEVFIELNADDNEQLMLRDYCEDD-K----- -LRDIVPET--PTSAPPPKTSICT-ADQCRNYCKAP----TSGGSTGTIDV-TDKENQIT FEDQLHNYVYI------------K----------NPLLRDKTTRRKRSTNLL-------- -------FPNNTENKKN----DTTDRR-------TEKVKDEPYYQYIF--NATNETSITF PLSYFNHYSLYVFKIRACRHPGDPPAPSVRLVDVELACGNEVFENFRT------------ --------PKKEGADDIPPESILIEEQSNNTQRQIRVQWKEPSKPNGPIVKFVVKYQRV- -------DLESVSSTDICIRYSSFNQTRGALLTKLEPGNYSIRVMATTIAGDGAPSAARY VLIAKD---DSMGTTLIWLG----T--LIVIFLCSVGFVAFY-WY----------KYRYM SKQ--------------------------------------------------------- ----------------------------IRMY---------------------------- --------------------------------PEVN-PDY--AGV--------------- ------QYKVDD--WEVERNHIIQLEELGQGSFGMVYKG-ILTQLR-------------- GEKCNQPCAIKT---------VNESATAREKDSFLLEASVMK-----QFNTHHVVRLL-- ---------------GVVSQGDPTLVIMEL-MANGDLKSYL-RRHRP-DYENG------- ---EDP-SP---------QPPTLRQIIQMAIEIADGMAYLSAKKFVHRDLAARNCMVADD MTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLAS-QPYQGLTND Q----------------------------------------------------------V LRYV-----IDGG--VMERPENCPDNLYN-LMRRCWQHRPTARPTFMEIISELLPDASPH FQDVAFYNSQDALDMLRGQHQT----VI--IDEATTPLRPGDDHDEEPG----------- --------------------------EDDDLVGHGEGH------------IGDVGTDDEF SMEMTNSHLVRNNGPMA------------------------------------------- ------TIRSPHSPLR---- >T_nigroviridis_ENSTNIP00000002029 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------L-------RGC-----TVLHGNLIIKI R--GG-N---NIAAELESSLGQIEEITGYLTIR------RAYALVSLSFLRKLRVIKGEH LEID-TYAFHALDNQNLRELWDWSKHNLTIQRGRTFFHYNSKLCMSEIKKMVEVTGTESR NQKNDIAERTNGDQASCETKQLQFTSIKTSSN---------------------------- ------------------------------------------------IIMLKWEPFWP- PDFRDLLGFMVLYKEA-PYR--NVTEFDGQDACGSNSWAIADVDPPPRPTEG-KKADDPR HL---IKSLKPWTQYAIMVKTQ-LSASDE--HQVH------GAKSKIVYVRTNASKPSEP LDPISSSNSSSQITLKWKPPTSPNGNITHYRVICQKQSEDED-LYKFDYCLQGMK----- -LPSRT-PT-HLDSKKEEKWNDTG-EPTSEGRCCAC----PKTDNQLKKEQ-EEIEYRKT FENYLHNKVFE------------PHLTRFFSRSFRP------SRRRRS-VGVANATQ--- ---STFSLTTVSNVLLN----STTPAPNQ-----EE---EEGKVELNV--FSK-ESTV-- -ISNLHHFTSYKIEIMACNHATD-----------LKRCSTETRVSART------------ --------MPEEKADDIPDE--VSHEIVAAEPPYVLIKWKEPESPNGLIILYEVFYGKV- -------GDTEV--HTACVSRPAYQKTGGTKLSLVQPGNYSVWVRATSLAGNGSFTKVTH FFVPN----PDPGLVWIVMG-----PIICFILLLFVGVGVFV-VF-K--------KKQTE GPT--------------------------------------------------------- ----------------------------GPLI---------------------------- --------------------------------ASSN-PEYLSAND--------------- ------VYVPDE--WEVPREKIALLRELGQGSFGMVYEG-IAKDIV-------------- KGDPETRVAVKT---------VNESASLRERIEFLNEASVMK-----AFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTHGDLKSYL-RSLRP-DSE--------- ---NNPSGR---------PPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--SLDRPDNCPERMHN-LMQMCWQYNPKMRPMFHEIIEMLREDLHPS FQEVSFFYSEENKVPETEEFDL----DL--DNMESIPLDP---SSYSQR----------- --------------------------EESL----GRDS--GP-------SVALRGNYEE- HVPYTHMNGGKKNGRIL------------------------------------------- ------SL--PRSSPS---- >M_domestica_ENSMODP00000015969 ------------------------------------------------------------ -----------------------------------------AGRGSPTSLWGLLFLFSTL CLWPTNGE--ICGPHIDIRNEIQELKRLENCTVIEGYLRILLIS-------KAEDYRNFR FPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGKNLFYNYALVIFEMTNLKEIGLYNLR NITRGAIRIEKNSELCYLSTVDWSLILDAVSNNYIVGNKNP-KECGDLCPGTME------ -EKPLCEKTTINN----EYSFRCWTTNHCQKMCPSSCGKRACTDQNECCHPE-CLGSCSA PDNN---TACVACRHYYYA----GTC-VPTCPPNTYKFEGWRCVDKDFCAS-VLSAE--- -------TSEFEKFVIHNDEC-------MQE--CPSGFIRNG-----SQ----SMYCSPC EGPCPKVC-EGEKKTKTIDS-----VTS--AQML-------QGC-----TVFKGNLLINI R--RG-N---NIASELENFMGLIETVTGYVKIR------HSHALVSLSFLKNLRYILGEE QLEG-NYSFYVLDNQNLQQLWDWNLHNLTIKEGKMYFAFNPKLCVSEIYRMEEVSGTKGR QSKGDINTRNNGERASCESDVLHFISNTTMKN---------------------------- ------------------------------------------------RIKLTWQRYRP- PDYRDLISFTVYFKEA-PFK--NVTEYDGQDACGSNSWNMVDVDLP-----P-NKDVKPG IL---LQGLKPWTQYAIYVKAVTLTMVEN--DHIR------GAKSEIVYIRTKAAVPSIP LDVISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSY-LYRHNYCSKD-K----- -VPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCAC----PKTEAEKQAEK-EEAEYRKV FENFLHNSIFV------------P----------RP------ERRRRDVFQIANSTMPSR -------NRNTTVADHF----TNMSDA-------EEIETEYPFFESRV--DNK-ERTL-- -ISHLRPFTLYRIDIHSCNHEAD-----------TLGCSASNFVFART------------ --------MPAEGADNIPGP--VLWEE--RPDNTVHLKWPEPENPNGLILMYEIKYGQQ- -------VE-DQ--R-ECISRQEYRKFGGAKLTRLNPGNYSARVQATSLSGNGSWTDPVF FYVPPKTGQDYENFLHLMIA----LPIAGLFIVGGLLIMWYV-FNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAD--------------- ------VYVPDE--WEVPREKITMSRELGQGSFGMVYEG-TAKGVV-------------- KDEPETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-ETE--------- ---NNP-CQ---------MLPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDELDPG FKEVSFFYSEENKPPDTEELDL----ET--ENMESIPLDP---SSTLQP----------- ---------------------------ADKHSGHKAEN--GP------GVVVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >G_gallus_ENSGALP00000005655 ------------------------------------------------------------ ------------------------------------------------------------ ----------VC-RSMDIRNNLTRLSLLENCTVIEGHLQILLMF-----KTKPEDFRELS FPKLTMITDYLLLFRVYGLESLKGLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLM NITRGAVRIEKNNELCYLSTIDWSRILDSVEDNYIIANKDDKEECGDVCPGTVK------ -GKSNCPPTVING----IFIERCWTHDRCQRVCPPACKSQGCTSDGQCCHSE-CLGDCTE PNNA---ERCVACRNFYLD----GTC-VETCPPGHYRFEGWRCVTFSFCQE-LHNKCK-- ----SARESGCH--VIHNNEC-------VHE--CPSGY-IMN-----SS----NLHCTPC AGPCPKVCDYG--KEKTIDS-----VTS--AQEL-------RGC-----TVVNGSLVINI R--GG-N---NIAAELEANLGLIEEISGYLKIR------RSYALVSLSFFRKLHLIRGET LEAG-NYSFYALDNQNLRQLWDWSKHNLTIARGKLFFHYNPKLCLSEIHKMEEISGTKGR QERNDIALKTNGDQASCENELLKFSSIRTSHD---------------------------- ------------------------------------------------KILLKWEPYWP- PDFRDLLGFMLFYKEA-PYQ--NVTEFDGQDACGSNSWTVVDVDPPPRSNEP-KAQAQPG WL---LRGLKPWTQYAVFVKTL-VTFSDE--RRTY------GAKSEIIYVQTNATVPSVP LDPISVSNSSSQIILKWKPPSEPNGNITHYLVYWQQQAEDSE-LYELDYCLKGLK----- -LPSRTWSP-PFESEDPQKYNQSE-SEDVSGECCSC----PKTDSQIQKEL-EESAFRKT FENYLHNEVFV------------P----------RP------SRKRRDLGSIANATV--- ---V---IPTIPSSPN-----SSAAAS-E-----SA---EEQKPFEKV--KFK-ESLV-- -ISGLRHFTGYRIELHACNHDAQ-----------ESRCSVAAYVSART------------ --------MPEAKADDIVGP--VTHELV--EKNTVHLKWQEPKEPNGLIVLYEVNYGRL- -------GEAEE--AHFCVSRKHFASEQGCKLRGLQPGNYSVRIRATSLAGNGSWTEPTY FYVADYLN-AQPNIAVIIV------PIIFAIIIAGIIGAAYV-LV-K--------KRQTE GPT--------------------------------------------------------- ----------------------------GPLY---------------------------- --------------------------------ASSN-PEYLSASD--------------- ------VYVPDE--WEVPREKITLLRELGQGSFGMVYEG-IAKDIV-------------- KGELETRVAVKT---------VNESASLRERIEFLNEASVMK-----GFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MAHGDLKSYL-RSLRP-DAE--------- ---NNP-GR---------PPPTLREMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTTYSDVWSFGVVLWEISSLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDQPDNCPERLHN-LMQMCWQYNPKMRPTFIEVIEMLKEDLHPS FQEVSFFYSEENKPLETEEYEM----DF--ENMESIPLDP---SSYTQR----------- --------------------------DKAL----GRDN--GP-------SMALKGNYEE- HIPYTHMNGGKKNGRIL------------------------------------------- ------SM--PRSSPS---- >A_carolinensis_ENSACAP00000012295 ------------------------------------------------------------ ------------------------------------------------------------ ----------M---LTPPQAL-----FVIMLLVIS---SAVKAQ-----VNPAICRYPLG MSGGHIPDEDISASSQWSESTAAKYGRLGSEDGDGAWCPEIPVEPDDLKEFLEIDLHALH FITLVGTQGRHAGGHGNEFAPMYKINYSRDGTRWISWRNRH------------------- ------------------------------------------------------------ -------GKQVLDGNTNPY----DIVLKDLEPPIIGR-FIRFIPVTDHSSN-V------- -----------------------------------------------------CLRVELY G-----CI-------WL-DG-----LVSYSAPAG-------QQL-----VLPGGIVIYLN DSIYD------GY-SMTEGLGQLTDGVSGLDDF-----IQTHEYHVWPGYDYVGWRNEST NNGY-VEITFEFDRIRNFTTM-KVHCNNMFDKGVKIFKE-----VQCHF-RSDSNEWEPN PISSVLVLDDVNPSARFVTVPLLHHMANAIK----------------------------- ------------------------------------------------------------ -CQFYFADTWMMFSEI-TFQ--SD------------------------------------ -----AAMYNNSGAIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ESSVTPTT---YDPTLKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQFWKKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNHNH---STSS--S EPESSSTYD-RIFPLG-PDYQEP-----SQLIRKLPEFTP---KEEE------------- -----------------AGCSGITKPALPS--GVEGVPHYAEADIVNLQGVTGSNTYSVP AITMDLLSGKDVAVAEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEMFMDNGS---ILDG DLKQPVLLAVKM---------LRADANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRQEL-QSLIV------- -----S-SA---------SAVSYADLKLIATQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCREQPYSQFSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPALCPDYIYK-LMLTCWRRDTKDRPSFQEIHCLL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------- >O_latipes_ENSORLP00000013617 ------------------------------------------------------------ ------------------------------------------------------------ ----------------LGETRIMEFKVIRLFVLLA---ATVEAQ-----VNPEVCRYPLG MTGGQIQDEDISASSYWSESTAAKFGRLDIGGGDGAWCPDIMSEPHGLKEYLQVDLRSLH FITLVGTQGRHADGMGNEFAQRYRIKYSRDGSNWVSWQDRK------------------- ------------------------------------------------------------ -------GQQVIEGNRNAY----DVVLKDLEPPIIAR-YVRFMPVTDHSMI-V------- -----------------------------------------------------CMRVELY G-----CE-------WL-DG-----LVSYSIPDG-------HQM-----IYR-DLEVSFN DSVYDG---ASAEGSLTKGLGQLTDGTWGLDDF-----LHSQIYGVWPGYDYVGWSNRTF PKGY-VEMIFDFDHVRNFTSM-KVHTSNMFSRGVRVFRQ-----VTCFF-WSDS-EWEPG PITFRPTPDRVSQRARFVTVTLGDRTAKTIK----------------------------- ------------------------------------------------------------ -CRFHFSDVWMLFSEV-AFQ--SA------------------------------------ -----SLFKKCQMKVP---GLILPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AVSNRNTSTLNISV---DDPTHKV---------- ---DDS-------NTRILIG----CLVAVIAILSAIIVIMLWRQVWQKMLE----KASRR LLD---------------------------DDLTARLAIQNRAFAFRHSS---LSSD--S GSTSNSTYE-RIYPLC-ADYQEP-----SRLIRKLPEFAH---SAENLGKPQSLEKTLTI ALQKPRFEVISIFS---PESSSSCMAATAS--GSDGAPHYAEADIISLQESSDS---SIA AANMTPFTGTDSSLREFPREKLSFKEKLGEGQFGEVHLC-EAEGMQDFLDEDL---SVGE ISESLLLVAVKT---------LREDANKNARNDFLKEIRIMS-----RLRDPNIVRLL-- ---------------AVCVDTDPLWMITEY-MENGDLNQFL-CNLRL-KEAPDEDKPEQE EGED---SI---------SALSYTKLINMAVQIASGMKYLSSLNFVHRDLATRNCLVGKN YTIRIA-DFGMSRNLYKGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTMASDVWAFGVTLWEILTLCKEQPYSQLSDE Q----------------------------------------------------------V IENTGEFFRDKGKQVYLPKPPCCPDSVYNDLMLSCWRRNAKQRPSFQEIHAQLQENI--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LHCV >M_domestica_ENSMODP00000020864 ------------------------------------------------------------ -------------------------------------MTASSSWLWGACL---LMNFLPL GFGLDTPE--VC-PSLDIRTEVAELRRLENCTVVEGYLQILLIF-----TATGEDFQGLS FPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGNRLFFSYALVIFEMPHLRDVGLPGLG AILRGAVRVEKNQELCHLSTVDWGLLQPTTDANHIVGNKLG-EECADVCPGMLG------ -TEEPCIRTTVNG----RTDYRCWTSGHCQRVCPCARG-LACTPRGECCHPQ-CLGGCSR PNDP---QACVACRHFHFG----GTC-HSACPRGTYRYEAWRCVTADYCAS-LRALPD-- ------LPGHASDFVIHQGSC-------LAQ--CPPGYTHND-----S-----SIFCLKC EGLCPKEC---KVGTKTIDS-----LQA--AQEL-------VGC-----THVKGSLILNL R--QG-Y---NLEAELQQSLGLVETITGFLKIK------HSFALISLGFFRNLKLIQGDS MVDG-NYTLYVLDNQNLQQLGQWAEAGLSIPVGKIYFAFNPRLCLEHIYQLEEVTGTRGR QNKAEINPRTNGDRAACKTRSLRFVSNVTESD---------------------------- ------------------------------------------------RILLRWERYEP- LEARDLLSFIVYYKES-PFQ--NATEHMGPDACGAPNWNLLDVELP-----L-SRTQEPG VT---LAPLKPWTQYAVFVRAITLSMAED--SPHQ------GAQSPIIYLRTLPAAPTVP LDVISTSNSSSHLLVRWKPPTLRNGNLTYYLVLWQRLAEDAD-LYLNDYCQRGLR----- -LPTSSTDT-RFDQEEGEP------LAEAEPGCCPCQSPSPEQPQQPALEA-HEASFQKK FENFLHNAITL------------P----------RS------PWKVTSLNKSPQRDPGRY RRAS---RA---------------------PGE-GGNSSDFGI-QDKV---PR-ERAV-- -LSGLRHFTEYRIDIHACNHAAH-----------TVGCSAATFVFART------------ --------MPHREADSIPGK--VAWKP--ASKSSVLLHWPEPPDPNGLILKYEIKYKRL- -------GE-EA--TVLCVSRLRYAKFGGVHLALLPPGNYTARVRATSLAGNGSWTDGLA FYIPGSEEEESGGLHVLLTV----TPVGLLLLIV-LAALGFF-YSKK----------SGG YPN--------------------------------------------------------- ----------------------------GTLY---------------------------- --------------------------------ASVN-PEYFSTSD--------------- ------MYVPDE--WEVPREQISVIRELGQGSFGMVYEG-LAQGLE-------------- AGEAPTPVALKT---------VNELASLRERIEFLKEASVMK-----AFKCHHVVRLL-- ---------------GVVSQGQPVLVIMEL-MTRGDLKSYL-RSLRP-EAE--------- ---NNP-GL---------PRPGLGDMIQMAGEIADGMAYLTANKFVHRDLAARNCMVSQD FTVKIG-DFGMTRDVYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGIFSTHSDVWSFGVVLWEIVTLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MDNG--ILDEPEGCPPQLRE-LMSRCWQQNPRQRPTFLQILDSIKDELRPS FRLLSFYYSPESRGGRGSLAPPDTDPDTHLS------PEPP-PDFSPP------------ ------------------------------------------------------------ -------NGSLGH----------------------------------------------- -------------------- >O_anatinus_ENSOANP00000000255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VCPSVCGKRACTDQNECCHPE-CLGSCSA PDNS---TACVACRHYYYE----GTC-VPTCPPNTYKFEGWRCVNRDFCSK-VPGPD--- -------INEFEKFVIHNDEC-------MQE--CPSGFIRNG-----SQ----SMFCSPC EGPCPKIC-EEEKKTKTIDS-----VTS--AQML-------QGC-----TVFKGNLLINI R--RG-N---NIASELENFMGLIETVTGYVKIR------HSHALVSLSFLKSLRYILGEE QLEG-NYSFYVLDNQNLQQLWDWNHRNLTIKEGKMYFAFNPKLCVSEIYRMEEVSGTKGR QTKGDINTRNNGERASCESDILHFISNTTMKN---------------------------- ------------------------------------------------RIKLTWQRYRP- PDYRDLISFTVYYKEA-QMK--NKHEVR-KGKCMKHGWEKVAQDKPIDARTV--KSEKPN NLARYMMSLKQWAVFPMLSSYVVKHLMFSGLGHTY------LTSSSLVIVQS----PLSP SNSFSISFTGSSSVPDAFPFSHPNANFFLFAI-----------YFVLVYFNALTL----- -LPIVLWQSMFPHSSRTSSIARREEIYPGAIILCFC----PVTPTAYIKQMNSRSCLFKQ TKQYNQSLIRL------------FRGTASGSSILQP------SLPKLSLTEKGSKT---- -------PKNNTTPDSW-------------------------NLSLGV--RTG-KSQE-- -HQSARPSRLLRVTLQSLGYSQQ-----------ESEGTRIVALLNKTIRDSPLFHLPTL AYCLPQFRLAGKGADNIPGP--VTWEG-RKEDNTIYLKWMEPENPNGLILMYEIKYGQH- -------ME-DQ---RECISRQEYRKYGGARLTRLAPGNYSARVQATSLSGNGSWTEPVS FYVQAKGD----------------VRMNVLLIVGGLLIMLYV-FNKKRNAFFPFYRNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAADDFPSS---------- ------LYVPDE--WEVPREKITMCRELGQGSFGMVYEG-IAKGVV-------------- KDEPETRVAIKT---------VNESASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-DTE--------- ---NNP-GQ---------APPTLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAE-QPYQGMSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIIGSIKDELDPA FKEVSFFYSEENKPPDTEELDL----ET--ENMESIPLDP---SSTLQP----------- ---------------------------SEKHSGHKAEN--GP------GVVVLRASFDE- RQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >G_gallus_ENSGALP00000021608 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VCPCGAG-SACTASGECCHAE-CLGGCGR PRDS---RSCVACRHFHFN----GHC-LPSCPPRTYEYEGWRCITAEYCAS-LRKVSD-- ------NPRDASKFVIHQQQC-------LSE--CPPGYTRNE-----SSLCPCSIFCHKC EGLCPKAC---KVGTKTVDS-----TRA--AQEL-------AGC-----TLVEGNLILNI R--RG-Y---NLASELQSSLGLIETITGFLKIK------HSFALVSLSFFKNLKLIRGDS MVDG-NYTLYVLDNQNLQQLWDWSHHVLSIPVGKMYFAFNPKLCLAEIYHMEEVTGTKGR QNKAEINPRTNGDRASCECG---------------------------------------- ------------------------------------------------------------ ------------------------------DGDGGTRWHL---------------DSQPF -----SHPPTGKTQTLRFISNIT--------------------ESDRIFL-------SLP EDLLQLSLSYYKEVVKVNPSVSPSG-----ICLWSSAVTPTG---DSVRALGGLLWGPRT LTPTSSIPA-------------------------------PKRRRDLA------------ -------AVTS-------------------------------PFEASSVEPPPPSHTG-- ----------------------------------AEPKPDFQISEDKV---VR-DRVV-- -LSRLRHFTEYRIDIHACNHAAH-----------TVGCSAATFVFART------------ --------MPELQADNIPGN--VTWEP--ASKNSVLLRWQEPRNPNGLILKYEIKYSRE- -------SEEVT--TVVCVSRHRYAKYGGVHLALLQPGNYSAKVRATSLAGNGSWTGLVK FYILGPGT--RWGFYILLTV----TPVVLMVLISCLAVFVFF-YNKK--------RSNDG YPS--------------------------------------------------------- ----------------------------GTLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------MYIPDE--WEVSREKITVIRELGQGSFGMVYEG-LAMGLV-------------- AEGEETKVALKT---------VNELATMRERIEFLKEASVMK-----AFKCHHVVRLL-- ---------------GVVSQGQPALVIMEL-MTRGDLKSYL-RSLRP-DAE--------- ---NNP-GL---------PPPSLKDMIQMAGEIADGMAYLNAKKFVHRDLAARNCMVSED FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPEALKDGIFNTQSDVWSFGVVLWEITTLAE-QPYQGMSNE Q----------------------------------------------------------V LHYV-----MDNG--VLERPENCPDQLHE-LMCLCWQQNPRQRPSFVQLLESIKEHMAPA FRTLSFFYSPENRRRGSSE-PSDGETEQPPE--EDEPPAPPLPTRKGRG----------- ------------------------------------------------------------ ----RLPNGTG------------------------------------------------- -------------------- >T_nigroviridis_ENSTNIP00000017949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------L-------RGC-----TVLNGSLVINL R--GG-N---NIAAEMEASLGQLEEITGYLTVR------RSYALVSLSFFRKLRLIRGEE QETGRNYSFYAFDNQNLRQLWDWSKHKLSILQGRMFFHYNSKLCMSEIHKMEEVTGTKQR QVKNDIALKTNGDQASCETYVLNFTQVRTMSD---------------------------- ------------------------------------------------KIMVKWKSFWP- QDYRDLLGFMVLYKEA-PFQ--NVTEFDGQDACGSNSWVIADVDPPHRPPDGDKDKIEPG YL---ILPLKPWTQYAIMVKTQ-LSASDE--HQVH------GAKSEIIYVRTNATKPSVP LDPISSSNSSSQIILKWKPPNEPNGNITHYLVFCQAQQEASE-LYKFDYCQKGMK----- -LPSRV-PT-QVDNDEEQKWNKTE-EQGQGSRCCAC----PKTDKELKKEK-EDSEYRKT FENYLHNEVFE------------L----------KR------TRQRRSIVGVANQSH--- ---PLL-TTTLGPP-------HDTDVQ-E-----EDGTLKNQKTVVTV--HAK-ESTV-- -ISQLHHFTSYQIEIHACNHHTD-----------ASRCSMAAYVSART------------ --------LPEDKADDITGP--VNHSV---TENTVHIRWDEPSAPNGMIILYEVNYRRL- -------GDTEE--LHYCVSRNMYKVSRGCKLKVMHPGNYTVRVRATSLAGNGSWTEPTY FYVQDPS--DPLHVVKIVIG-----PVICSVLLLLVAVGGFV-MF-K--------KNQTQ GPS--------------------------------------------------------- ----------------------------GPIY---------------------------- --------------------------------ASSN-PEYLSAND--------------- ------VYEEDE--WEVPREKISILRELGQGTFGMVYEG-LAKDII-------------- KGEGETHVAVKT---------VNESANLRQRIEFLNEASVMK-----AFSCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTNGDLKSYL-RSLRP-DAE--------- ---NNP-GR---------PPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVGHD FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLSE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDRPDNCPDRLYN-LMQMCWQYNPKMRPTFLEIIEMLHDDLHPS FQDVSFFYSEENKPPESEDFDL----DM--ENMESIPLDP---SSYSQR----------- --------------------------DQCL----SRDE--GL-------SVGLRGSYEEH HVSFTHMNGGKTNGRIL------------------------------------------- ------AL--PRSSPS---- >D_rerio_ENSDARP00000046541 ------------------------------------------------------------ -------------------------------------MRSSKQRRYWTLFSGLVLVLSTL CHGE------ICGPGIDIGNDIGNFKRLENCTVIEGYLQILLIGDKN--SNNQEVFRTLS FPKLTMITDYLLLFRVSGLESLSTLFPNLAVIRGRNLFYNYALVIFELTSLKDIGLYNLR NITRGAIRIEKNPELCYLDSVDWSLILDAELNNFIDGNKQS-KECGNVCPGIME------ -DNSQC--------------TRCWTSNHCQKVC--RCGQRACTDSGQCCHPQ-CLGSCSV PDSD---RACAACQNYNHE----GRC-VEDCPPGTYKFEGWRCITRDFCSK-VH------ -------LPDYDRFVIHAGEC-------MSD--CPPGFTRDE-----SHGVSVSMLCTAC DGPCDKIC-----DEKVIDS-----VDA--AQSL-------KGC-----TVIKGNLHINI R--RG-T---NIASELENFLGLIKTVTGYIKIR------SSHTLTSLSFLKSLRYIHGEE LWDN-TYAFAALDNQHLQLLWDWSQHNLTISEGKLYFRLNPKLCMSEIRKMWAKTGIKDN FVERDF--RNNGDRASCGTKILKFTSNNTRSN---------------------------- ------------------------------------------------QIKLMWESYRP- SDSRDLVNFIVYYKEA-PFQ--NITEFDGQDSCGSDSWNMVDVDLP-----D-EKILNPG VV---LSALKPWTQYAIFVKAVTL-IVED--RDRDKDRLHLGPQSEVVYIRTKPSAPSMP VDIRAYSNSSSKLVVRWAPPLAPNGNNTYYLLRWKQQGEDRE-LYQHNYCSKELK----- -IPVRVSATGLTDTED-TKPTNHETGGRDKTPCCPC----PKTEEDLKRIE-DDIYYRKA FENFLHNAIFT------------P----------RP-----PDRRRRDLFGVANVT---- -------SIHTLLAGHWNLTEGNFSDD-------EPPRREFSFLERKV---KE-RHIE-- -ITGLQPFTVYRIDLHACNEEVR-------------HCSAAAFVFSRT------------ --------KAAEKADDIPGS--VTWEG---QEDSVFLKWPEPDKPNGLIMLYEIQYRLG- -------TE-PE--KHECVSRQHYRKHKGVKLSNLGPGNYSVRVRATSLAGNGSWTEPIA FSVHQLEQ-SSYDPVMFIAI----LPA--LLLIAGLVVFGYTWMNKN--------RNNDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAE--------------- ------MYVPDE--WEVEREKITMCRELGQGSFGMVYEG-IAKGVV-------------- KDEPETRVAIKT---------VNESASLHERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLR--SVE--------- ---NTS-SL---------PLPPLKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED FIVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTMSDVWSFGVVLWEIATLAE-QPYQGMSNE Q----------------------------------------------------------V LRFV-----MEGG--LLDKPDNCPDMLFE-LMRMCWQYNPKMRPSFLEIISSIKEDLEAG FKETSFFYSEENKPPDTEELDM----EN-VGTMENVPLEP---SSSLQP-------LAPS ISPPQQCTAAAQSCSSPSSPPSSPSSTDKHPLPTSAAN--GP-------SMVLRGPFEE- GQPYAHMNGGRKNERAL------------------------------------------- ------PL--PQSSAC---- >C_familiaris_ENSCAFP00000000658 ------------------------------------------------------------ ------------------------------------------------------------ ----------TSPRILGSWL------LLLLLYLVATGDADMKGH-----FDPAKCRYALG MQDRTIPDGDISASSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKE-EEYLQVDLRRLH LVALVGTQGRHAGGLGKEFSPSYRLRYSRDGHRWMDWRDRW------------------- ------------------------------------------------------------ -------GQEVILGNEDPG----GVVLKDLGPPMVAR-LVRFYPRADRVMS-V------- -----------------------------------------------------CLRVELY G-----CL-------WK-DG-----LLSYTAPVG-------QTM-----YL--SQAVHLN DSTYDGHTTHTVGGLLYGGLGQLADGVVGLDDF-----RKSQELRVWPGYDYVGWSNHSF LGGY-VEMEFEFDRLRAFQAM-QVHCNNMHTLGARLPGG-----VECRFKRGPAMAWEGE PVRHALGGSLGDPRARAVSVPLGGRVGRFLQ----------------------------- ------------------------------------------------------------ -CRFLFAGPWLLFSEI-SFI--SD--------------------------VV-ND----- -----SSPALVGTFPP---APWWPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GPPPTNFSSLELEPRG---QQPVAKA---------- ---EGS-------PTAILIG----CLVAIILLLLLIIALMLWRLHWRRLLSKSHDKAERR VLE---------------------------EELTVHLSVPGDTILINNRP---GPLE--- ----PPPYQ-EPRPRGNPPHSAPSVPNGSALLLSNPAYRL---LLATYARPPRGPGPPTP AWAKPTNTQACSGDYMEPEKPGAPLLPPP---PQNSVPHYAEADIVTLQGVTGGNTYAVP ALPPG-AAGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLC-EVENPQDLVSLDF---PLNV CKGHPLLVAVKI---------LRPDATKNARNDFLKEVKIMS-----RLKDPNIIRLL-- ---------------GVCVQDDPLCMITDY-MENGDLNQFL-SAHQL-EDKAAEGAPRDR EA---A-QG---------PTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN FTIKIA-DFGMSRNLYAGDYYR-------------------------------------- -------VQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDE Q----------------------------------------------------------V IENAGEFFRDQGRQVYLSRPPSCPLGLYE-LMLRCWSREPEQRPSFSQLHRFLAEDA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LNTV >O_latipes_ENSORLP00000022517 ------------------------------------------------------------ -------------------------------------------------FLCVFL----- ----------VC-PSKDIRNNVTNLQTLENCTVIEGHLKILLMF-----KTKPENFRGIS FPKLRVVTDYLLLFRVYGLESLSDLFPNLTVIRGNNLFFNYALVVFEMLQLRELGLHSLM NITRGAVRIEKNPDLCYLSTLDWSKILDTVEDNYIVANKND-RECGDVCPGVPR------ -GETLCPTTTLNG----HFSERCWTQKFCQKMCPVQCKHGACTDGGQCCHDQ-CLGGCLK PNST---SDCVACRGLQHE----GRC-VEQCPKKFVVYKGWRCVSSDFCQE-LHHRCR-- REKERSKSAECHEYVIHNGAC-------IPE--CPSGYTTVN-----SS----ALNCSPC AGLCPKVC----IGLKTVDS-----VTA--AQAL-------RGC-----TILNGSLVINL R--GG-N---NIAAELEASLGQLEEITGYLTVR------RSYALVSLSFFRKLRVIRGEE QEVG-NYSFYALDNQNLRQLWDWSKHKLAILQGRMFFHYNSKLCMSEIRRMEEVTGLKDR RVKNEIALKTNGDRASCENHVLTFTQIRTMSD---------------------------- ------------------------------------------------KIMIKWKPFWP- SDFRDLLGFMVLYKEA-PFQ--NVTEFDGQDACGSNSWVIADVDPPRRASEGEKDQTEPG HL---IMPLKPWTQYAIMVKTQ-LSASDE--HQVN------GAKSEIIYVRTNATRPSVP LDPISSSNSSSQIILKWKPPNDPNGNITHYLVFYQRQPEASE-LYKFDYCQKGMK----- -LPSRV-PT-QVDSGEEKKWNQTE-EEGQGKQCCTC----PKTDKELKKEK-EDSEYRKT FENYLHNEVFE------------I----------KR------PRQRRSAMGVANQTL--- ---PFL-TTAPSP----------TGIPDE-----DEKTFESTKTVVTV--HAK-ESTV-- -ISNLRHFTSYQIEIHACNKAIP-------------TCSMAAFVSART------------ --------MPEEKADDILGP--IRSEV---TENTVHIEWQEPATPNGIIILYEVIYKRL- -------VDSED--LHYCVSRKMYKKMHGCKLKVMHPGNYSVKIRATSLAGNGSWTQPSF FYVQDLS--DPLYVVKIIIG-----PIICFVLLLLVSVAGFV-VFKK--------KSQTQ GPS--------------------------------------------------------- ----------------------------GPIY---------------------------- --------------------------------ASSN-PEYLSANDASLKLST-------- ------VYEEDE--WEVPRDKIHILRELGQGSFGMVYEG-LAKDIV-------------- KGEGETHVAVKT---------VNESASLRERIEFLNEASVMK-----AFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTHGDLKSYL-RSLRP-DAE--------- ---NNP-GR---------PPPTLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD LTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MEGG--FLDRPENCPDRLHN-LMQMCWQYNPKMRPAFQEIIEMLRDDLHPS FQEVSFFYSKENKPPESEDFDL----DM--ENMESIPLDP---SSYSQR----------- --------------------------EQCS----EREE--AS-------PVGLRGSYEEH HIPFTHMNGVKNNGRIL------------------------------------------- ------AL--PRSSPS---- >G_aculeatus_ENSGACP00000022371 ------------------------------------------------------------ -------------------------------------MVFRCDSVMWLRTLCFVVTAVCV AVSCHRASGEVC-PSKDIRNNVTNLHTLENCTVIEGHLKILLMF-----STKPEDFRGLS FPKLTVVTDYLLLFRVSGMETLSNLFPNLTVIRGNKLFFNYALVMFEMLHLREIGLHSLM NITRGAVRIEKNSDLCYLSTLDWSKILDTVEDNYIMANKNG-RECGDVCPGVAI------ -GKTTCQSTTING----HFSERCWTQNHCQRMCPVQCKHRACTKDDQCCHEQ-CLGGCLK PHSA---GHCVACRGLQHG----PSC-VERCPADHFTYKGWRCVPFAFCQD-LHNKCK-- REKEHSKSADCHEYVIHDGAC-------VPE--CPSGYTTVN-----SS----SLNCTPC AGLCPKVC----MGLKVVDS-----VTA--AQDL-------RGC-----SVLNGSLVIKL R--GG-N---NIAAELETSLGQLEEITGYLSVR------RSYALVSLSFFRKLRVIRGEE QEIG-NYSFYALDNQNLRQLWDWSKHNLTILQGRMFFHYNSKLCMAEIKKMETVTGTKER NVKNDIALKTNGDQASCENYVLKFTQIRTSSD---------------------------- ------------------------------------------------KIMIRWEPFWP- PDFRDLLGFMVLYKEARPFQ--NVTEFDGQDACGSNSWVIADVDPPQRATEGDKEQFEPG HL---IMPLKPWTQYAIMVKTQ-LSASDE--HQVN------GAKSEILYVRTNSTKPSVP LEPMSSSNSSSQIILKWKPPNDPNGNITHYLVFCQRQPEGSE-LYKFNYCQKGMK----- -LPSRV-PT-QVDSHEEQKWNQTE-ERGQGKRCCDC----PKTEKELKKEK-EDSDYRKT FEDYLHNEVFE------------I----------KR------SRKRRSAVGIANWTL--- ---PFL-TTAPSPP-------HGTGMP-E-----DEDAFEITRITVDVKAHAK-ESTV-- -ISNLRHFTSYQIEVHACNDKEN-----------PLSCSMAAYVSART------------ --------MPEDKADDIRGP--IKYEV---TENVVHITWQEPVSPNAVIILYEVNYKRL- -------GDTDE--LHYCVSRNMYKVARGCKLKVMHPGNYTVRIRATSLAGNGSWTEPTY FFVQDPS--DSLYVLKIIIG-----PVICFVLLLFVAVAGFV-MF-K--------KNQTQ GPS--------------------------------------------------------- ----------------------------GPIY---------------------------- --------------------------------ASSN-PEYLSAND--------------- ------VYEADE--WEVPRDKINILRELGQGSFGMVYEG-IGKDII-------------- KGEGDMHVAVKT---------VNESASLRERIEFLNEASVMK-----AFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MTNGDLKSFL-RSLRP-DAE--------- ---NNP-GR---------PPPSLKEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD LTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTANSDCWSFGVVLWEISTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDRPDNCADRIHN-LMQMCWQYNPKMRPAFQEVIEMLREDLHPS FREVSFFYSEENKPPETEDFDL----DM--ENMESIPLDP---SSYSQR----------- --------------------------EQCS----DRDE--GL-------SMGLRGSYEEH HIPFTHMNGGKTNGRIL------------------------------------------- ------AL--PRSSPS---- >B_taurus_ENSBTAP00000016858 ------------------------------------------------------------ ------------------------------------------------------------ -----LFALPVC-PGMDIRNNLTRLHELANCSVIEGHLQILLMF-----KTRPEDFRDLS FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAK------ -GKTNCPATVING----QFVERCWTHSHCQKVCISICVSEGTDTEHLKCPTA-VLGTSAL PYIPPSTTKCLVVFDNYFH----KSCLLSTAPKTYIYIYMYVCFNFNICQDKFHTQKK-- ----KKKKTTLSQYIQHRARF-------VPDGLSSSPF-TVNALFGGSS----VLLPTGL GAPFPPVCHQGSQAEKQPSG-----MHSRKCKEF-------TGR-----TILNVFIVIYY N--IA-SVFCSKAGGTEGNLNFIDKISLYLNLK-----GSSYCLCSSSLENKLQEIGGEL RNLR-NYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR QERNDIALKTNGDQASCENELLKFSYIRTSYD---------------------------- ------------------------------------------------KILLKWEPYWP- PDFRDLLGFMLFYKEA-PYQ--NVTEFDGQDACGSNSWTVVDIDPPTRSNDP-KSQNHPG WL---MRGLKPWTQYAIFVKTL-VTFSDE--RRTY------GAKSDIIYVQTDATNPSVP LDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSE-LYELDYCLKGLK----- -LPSRTWSP-PFESEGSQKHNQSE-YEESAGECCSC----PKTDSQILKEL-EESSFRKT FEDYLHNVVFI------------P----------RP------SRKRRALGDVGNVTA--- ---A---VPTALGLPNT----SSTSTP-M-----SS---EEHRPFEKV--VNK-ESLV-- -ISGLRHFTGYRIELQACNQDSP-----------EERCSVAAYVSART------------ --------MPEAKADDIVGP--VTHEIF--ENNVVHLMWQEPKEPNGLIVLYEVSYRRY- -------GE-EE--LHLCVSRRHYALERGCRLRGLLPGNYSVRVRATSLAGNGSWTEATY FYVTDYY--VPSNIAKIIIG-----PLIFVFLFSVVIGSICL-FL-R--------KRQPD GPL--------------------------------------------------------- ----------------------------GPLY---------------------------- --------------------------------ASSN-PEYLSASD--VFPCS-------- ------VYVPDE--WEVPREKITLLRELGQGSFGMVYEG-NARDIV-------------- KGEAETRVAVKT---------VNESASLRERIEFLNEASVMK-----GFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MAHGDLKSYL-RSLRP-EAE--------- ---NNP-GR---------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDQPDNCPERVTD-LMRMCWQFNPKMRPTFLEIVDLLKDDLHPS FPEVSFFHSEENKAPESEELEM----EF--EDMESVPLDR---ASHAQR----------- --------------------------EEAG----GRDG--GS-------ALGLKRNYDE- HIPYTHMNGGKKNGRIL------------------------------------------- ------TL--PRSNPS---- >P_troglodytes_ENSPTRP00000017670 ------------------------------------------------------------ -------------------------------------IGTGGRRGAAAAPLLVAVAALLL GAAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMF-----KTRPEDFRDLS FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAK------ -GKTNCPATVING----QFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSE-CLGNCSQ PDDP---TKCVACRNFYLD----GRC-VETCPPPYYHFQDWRCVNFSFCQD-LHHKCK-- ----NSRRQGCHQYVIHNNKC-------IPE--CPSGY-TMN-----SS----NLLCTPC LGPCPKVCHLL-EGEKTIDS-----VTS--AQEL-------RGC-----TVINGSLIINI R--GG-N---NLAAELEANLGLIEEISGYLKIR------RSYALVSLSFFRKLRLIRGET LEIG-NYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR QERNDIALKTNGDQASCENELLKFSYIRTSFD---------------------------- ------------------------------------------------KILLRWEPYWP- PDFRDLLGFMLFYKEA-PYQ--NVTEFDGQDACGSNSWTVVDIDPPLRSNDP-KSQNHPG WL---MRGLKPWTQYAIFVKTL-VTFSDE--RRTY------GAKSDIIYVQTDATNPSVP LDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSE-LFELDYCLKG------- -----------------------E-YEDSAGECCSC----PKTDSQILKEL-EESSFRKT FEDYLHNVVFVPRKTSSGTGAEDP----------RP------SRKRRSLGDVGNVTV--- ---A---VPTVAAFPNT----SSTSVP-T-----SP---EEHRPFEKV--VNK-ESLV-- -ISGLRHFTGYRIELQACNQDTP-----------EERCSVAAYVSART------------ --------MPEAKADDIVGP--VTHEIF--ENNVVHLMWQEPKEPNGLIVLYEVSYRRY- -------GD-EE--LHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTY FYVTDYLD-VPSNIAKIIIG-----PLIFVFLFSVVIGSIYL-FL-R--------KRQPD GPL--------------------------------------------------------- ----------------------------GPLY---------------------------- --------------------------------ASSN-PEYLSASD--VFPCS-------- ------VYVPDE--WEVPREKITLLRELGQGSFGMVYEG-NARDII-------------- KGEAETRVAVKT---------VNESASLRERIEFLNEASVMK-----GFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MAHGDLKSYL-RSLRP-EAE--------- ---NNP-GR---------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDQPDNCPERVTD-LMRMCWQFNPKMRPTFLEIVNLLKDDLHPS FPEVSFFHSEENKAPESEELEM----EF--EDMENVPLDR---SSHCQR----------- --------------------------EEAG----GRDG--GS-------SLGFKRSYEE- HIPYTHMNGGKKNGRIL------------------------------------------- ------TL--PRSNPS---- >X_tropicalis_ENSXETP00000039063 ------------------------------------------------------------ -------------------------------------MDRQGSLLVPSCLKGVLLILLVF NTNGDATH--FC-GSMDIRNDVSQFRKLENCTVIQGNLQILLMF-----STKPEDFRGLR FERLTMITEYLLLFRVYGLESLRDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLYSLT NILNGAVRIERNQELCHISTIDWSLLSESVENNYIVGNKPV-EECADVCPGIRD------ -SGESCIKTPING----NMESRCWTSTSCQKVCPCKED-IACSNTGECCHPE-CLGGCNK AGDP---RACVACRNFYID----DQC-LPSCPPGTFEYEGWRCIEEAYCGN-LLKESE-- -------NSESTKFVIFENRC-------LSE--CPSGYTRND-----S-----SIFCHKC EGLCPKTC---KAGNKVIDS-----LEA--AKEL-------TGC-----TNIEGNLILNI R--RG-H---NLASELQQSLGLIETITGFLKIK------HSFALVSLSFFKNLKLIRGDT MVDG-NYTLYILDNQNLLQL--WTPESLSIPVGKLYFAFNPKLCLSEIYHMEEITGTRGR QNKADINPRTNGDQASCNIRPLRFVSNWTEAD---------------------------- ------------------------------------------------RINLKWERYQP- -PGHDLLSFVVHYKES-PFQ--NITEYLGQDACGANSWNVVDVELP-----L-NNEQEPS VT---LTNLKPWVQYAIYVRAITLTAEEN--GRKF------GAQSDVVYIRTRPAAPTVP QDVMIMSNSSSHLIVRWKPPTQRNGNLTYYLVLWQQMVEDKE-LYLNNYCTKGLK----- -LPTSSADT-RFDNDDNGNQDP---NQDTEDKCCPC-----QKDGGLHPEM-DEGSFQKK FENFLRNTIFI------------P----------KP------PWKVTLINKDNQRAPKRR RDVP---GMNPEVLGNASLPEGTVSHT---INH-TGVDSKPYSYKDKV---FL-NRMV-- -ISNLRHFTEYRIDIHACNHAAE-----------IVGCSAATFVFART------------ --------MQDPLADNIVGN--ITWEV--TAKNAILMKWEEPKNPNGLILKYEIKYKRD- -------HE-EGPPTVVCVSRQQFQRYKGVHLTLLQPGNYSARIRATSLAGNGSWTEPMV FFILGPEE-PSENLYLLLKV----LPIILLVVIAFLAVFIFF-YNKK--------GNNNG YPN--------------------------------------------------------- ----------------------------GTLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------MYVPDE--WEFPRENITIIKELAQGSFGMVYEG-VAKDIV-------------- KNEPVTRVALKT---------VNELATTRERIEFLNEASVMK-----AFLCHHVVRLL-- ---------------GVVSQGQPALVIMEL-MTRGDLKSYL-RSLRP-DEE--------- ---NNH-PG---------NQPSLKRMIQMAGEIADGMAYLTAKKFVHRDLAARNCMVSED LTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKSLLPVRWMSPESLKDGIFTTYSDVWSFGVVLWEIATLAE-QPYQGMANE Q----------------------------------------------------------V LHFV-----IDNG--ILEKPENCPDRLHE-LMRWCWQKNPKHRPSFIQILESIKDELPTS FQQVSFCNSQERKRSGSME-TSDTEVDQSLNNLLDQPPSPSFNNCSSQA----------- ----------------------------------------KEEKGNSLKAIATKRDSSK- NKNCYHMNGHAKH----------------------------------------------- -------------------- >M_mulatta_ENSMMUP00000016307 ------------------------------------------------------------ -------------------------------------MAVPSLWPWGACL---PVIFLSL GFGLDTVE--VC-PSLDIRSEVAELRRLENCSVVEGHLQILLMF-----TATGEDFRGLS FPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVGLPALG AVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLG-EECADVCPGVLGA----- -AGESCAKTTFSG----HTDYRCWTSSHCQRETAGSHG-AGWSQDGMAQYFQ-------- -------CHCFLIR---------------THPMRQVRKQREKLNNQCGIRQ-LRA----- -------AGECREGGGHPGSSEGLRRPKLVQ---GSGYLLAP-----A-----SIFCHKC EGLCPKEC---KVGTKTIDS-----IQA--AQDL-------VGC-----THVEGSLILNL R--QG-Y---NLEPQLQHSLGLVETITGFLKIK------HSFALVSLGFFKNLKLIRGDA MVDG-NYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGR QNKAEINPRTNGDRAACQTRTLRFVSNVTEAD---------------------------- ------------------------------------------------RILLRWERYEP- LEARDLLSFIVYYKES-PFQ--NATEHVGPDACGTQSWNLLDVELP-----L-SRTQEPG VT---LASLKPWTQYAVFVRAITLTTDED--SPHQ------GAQSPIVYLRTLPAAPTVP QDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGD-LYLNDYCHRGLR----- -LPTSNNDP-RFDREDGDP------EAEMESGCCPCQHP-PPGQVLPPLEA-QEASFQKK FENFLHNAITI------------P----------KS------PWKVTSINKSPQRDSGRH RRAT---GP---------------------LRL-GDNSSDFEIQEDKV---PR-ERAV-- -LSGLRHFTEYRIDIHACNHAAH-----------TVGCSAATFVFART------------ --------MPHREADGIPGK--VAWEA--SSKNSVLLRWLEPPDPNGLILKYEIKYRRL- -------GE-EA--TVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVA FYILGPEEEDAGGLHVLLTA----TPVGLMLLIV-LAALGFF-YGKK--------RN--- ------------------------------------------------------------ ----------------------------RTLY---------------------------- --------------------------------ASVN-PEYFSASD--------------- ------MYIPDE--WEVPREQISIIRELGQGSFGMVYEG-LARGLE-------------- AGEESTPVALKT---------VNELASPRERIEFLKEASVMK-----AFKCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTHGDLKSHL-RSLRP-EAE--------- ---NNP-GL---------PQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQD FTVKIG-DFGMTRDVYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--VLEELEGCPLQLQE-LMSRCWQPNPRLRPSFTHILDSIQEELRPS FRLLSFYYSSECQGARGSLPPTDAEPDSSPT------PRGASSDCSPQ------------ ------------------------------------------------------------ -------NGGPGH----------------------------------------------- -------------------- >H_sapiens_ENSP00000303830 ------------------------------------------------------------ -------------------------------------MATGGRRGAAAAPLLVAVAALLL GAAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMF-----KTRPEDFRDLS FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAK------ -GKTNCPATVING----QFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSE-CLGNCSQ PDDP---TKCVACRNFYLD----GRC-VETCPPPYYHFQDWRCVNFSFCQD-LHHKCK-- ----NSRRQGCHQYVIHNNKC-------IPE--CPSGY-TMN-----SS----NLLCTPC LGPCPKVCHLL-EGEKTIDS-----VTS--AQEL-------RGC-----TVINGSLIINI R--GG-N---NLAAELEANLGLIEEISGYLKIR------RSYALVSLSFFRKLRLIRGET LEIG-NYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR QERNDIALKTNGDQASCENELLKFSYIRTSFD---------------------------- ------------------------------------------------KILLRWEPYWP- PDFRDLLGFMLFYKEA-PYQ--NVTEFDGQDACGSNSWTVVDIDPPLRSNDP-KSQNHPG WL---MRGLKPWTQYAIFVKTL-VTFSDE--RRTY------GAKSDIIYVQTDATNPSVP LDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSE-LFELDYCLKGLK----- -LPSRTWSP-PFESEDSQKHNQSE-YEDSAGECCSC----PKTDSQILKEL-EESSFRKT FEDYLHNVVFVPRKTSSGTGAEDP----------RP------SRKRRSLGDVGNVTV--- ---A---VPTVAAFPNT----SSTSVP-T-----SP---EEHRPFEKV--VNK-ESLV-- -ISGLRHFTGYRIELQACNQDTP-----------EERCSVAAYVSART------------ --------MPEAKADDIVGP--VTHEIF--ENNVVHLMWQEPKEPNGLIVLYEVSYRRY- -------GD-EE--LHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTY FYVTDYLD-VPSNIAKIIIG-----PLIFVFLFSVVIGSIYL-FL-R--------KRQPD GPL--------------------------------------------------------- ----------------------------GPLY---------------------------- --------------------------------ASSN-PEYLSASD--VFPCS-------- ------VYVPDE--WEVSREKITLLRELGQGSFGMVYEG-NARDII-------------- KGEAETRVAVKT---------VNESASLRERIEFLNEASVMK-----GFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MAHGDLKSYL-RSLRP-EAE--------- ---NNP-GR---------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDQPDNCPERVTD-LMRMCWQFNPKMRPTFLEIVNLLKDDLHPS FPEVSFFHSEENKAPESEELEM----EF--EDMENVPLDR---SSHCQR----------- --------------------------EEAG----GRDG--GS-------SLGFKRSYEE- HIPYTHMNGGKKNGRIL------------------------------------------- ------TL--PRSNPS---- >R_norvegicus_ENSRNOP00000001102 ------------------------------------------------------------ ------------------------------------------------------------ ----------MGTGTLSS--------LLLLLLLVTIGDADMKGH-----FDPAKCRYALG MQDRTIPDSDISVSSSWSDSTAARHSRLESSDGDGAWCPAGPVFPKE-EEYLQVDLRRLH LVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMDWKDRW------------------- ------------------------------------------------------------ -------GQEVISGNEDPG----GVVLKDLGPPMVAR-LVRFYPRADRVMS-V------- -----------------------------------------------------CLRVELY G-----CL-------WR-DG-----LLSYTAPVG-------QTM-----QL--SEMVYLN DSTYDG---YTAGGLQYGGLGQLADGVVGLDDF-----RQSQELRVWPGYDYVGWSNHSF PSGY-VEMEFEFDRLRSFQTM-QVHCNNMHTLGARLPGG-----VECRFKRGPAMAWEGE PVRHALGGSLGDPRARAISVPLGGHVGRFLQ----------------------------- ------------------------------------------------------------ -CRFLFAGPWLLFSEI-SFI--SD--------------------------VV-ND----- -----SS----DTFPP---APWWPP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GPPPTNFSSLELEPRG---QQPVAKA---------- ---EGS-------PTAILIG----CLVAIILLLLLIIALMLWRLHWRRLLS----KAERR VLE---------------------------EELTVHLSVPGDTILINNRP---GPRE--- ----PPPYQ-EPRPRGTPTHSAPCVPNGSALLLSNPAYRL---LLATYARPPRGPGPPTP AWAKPTNTQACSGDYMEPEKPGAPLLPPP---PQNSVPHYAEADIVTLQGVTGGNTYAVP ALPPG-AVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLC-EVEDPQDLVTSDF---PISV QKGHPLLVAVKI---------LRPDATKNARNDFLKEVKIMS-----RLKDPNIIRLL-- ---------------GVCVQDDPLCMITDY-MENGDLNQFL-SAHQL-ENKVTQGLPGDR ES---D-QG---------PTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGEN FTIKIA-DFGMSRNLYAGDYYR-------------------------------------- -------VQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDE Q----------------------------------------------------------V IENAGEFFRDQGRQVYLSRPPACPQTLYE-LMLRCWSREPEQRPPFSQLHRFLADDA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LNTV >R_norvegicus_ENSRNOP00000018638 ------------------------------------------------------------ -------------------------------------MAVPALWPWGVYL---LMSLLSL GSCLDTLE--VC-PSLDIRSEVTELRRLENCSVVEGHLQILLMF-----AATGEDFRGLS FPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGARLFLGYALIIFEMPHLRDIGLPSLG AVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLG-EECADVCPGVLGA----- -AGEPCVRTTFGG----HTDYRCWTSSHCQRVCPCPRG-LACTVGGECCHSE-CLGGCSQ PEDP---RACVACRHLYFQ----GVC-LPTCPPGTYQYESWRCVTAELCGH-LRE----- ------VPGHATAFGIYEGSC-------LAQ--CPPGFTRNG-----S-----SIFCHKC EGLCPKEC---KVGTKTIDS-----VQA--TQDL-------VGC-----THVEGSLILNL R--QG-Y---NLEPELQRNLGLVETITGFLKIK------HSFALVTLGFFKNLKLIRGDS MVDG-NYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGTRGR QSKAEINPRTNGDRAACQTRTLRFVFNLTEED---------------------------- ------------------------------------------------RILLRWERYEP- LEARDLLSFIVYYKES-PFQ--NATEHVGPDACGTQSWNLLDVELP-----L-SRTQEPG VT---LAPLKPWTQYAVFVRAITLTTAED--SPHQ------GAQSPIVYLRTLPAAPTVP QDVISTSNSSSHLLVRWKPPVQRNGNITYYLVLWQRLAEDGD-LYINDYCHRGLR----- -LPTSSHDT-RFDREDPAL------EAEPEQGCCPCQHS-PPGQALPALEA-QEVTFQKK FENFLHHAITI------------P----------KA------PWKVTSINKNPQRDSERH RRET---GL---------------------LRL-GKNNSDFEIHEDKV---PR-ERAV-- -LSGLRHFTEYRIDIHACNHAAH-----------TVGCSAATFVFART------------ --------MPHREADGIPGK--VVWKA--VGKSSVILHWLEPPDPNGLILKYEIKYRRL- -------GE-EA--TVLCVSRLRYAKVGGVHLALLPPGNYSAKVRATSLAGNGSWTDGVA FYITGPEEEDTGGLRILLTV----TPVGFMLLVM-LAALGFF-YSKK--------RN--- ------------------------------------------------------------ ----------------------------STLY---------------------------- --------------------------------TSVN-PEYFSASH--------------- ------MYVPDE--WEVPREQIAIIRELGQGSFGMVYEG-LARGLE-------------- AGEESTPVALKT---------VNELASARERVEFLKEASVMK-----AFKCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSHL-RSLRP-EAE--------- ---NNP-GL---------PQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQD FTVKIG-DFGMTRDVYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--VLEEQEDCPIQLQE-LMRRCWQHTPRLRPTFVHILDRIQDELRPS FRLCSFYYSPECQRGQASLLPTEAEPDSPPT------LNGA-SDYGPP------------ ------------------------------------------------------------ -------NGDPGH----------------------------------------------- -------------------- >P_pygmaeus_ENSPPYP00000010619 ------------------------------------------------------------ -------------------------------------MGTGGRRGAAAAPLLVAMAALLL GAAGHLYPGEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMF-----KTRPEDFRDLS FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNY------------------- --------------------IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAK------ -GKTNCPATVING----QFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSE-CLGNCSE PDDP---TKCVACRNFYLD----GRC-VETCPPPYYHFQDWRCVNFSFCQD-LHHKCK-- ----NSRRQGCHQYVIHNNKC-------IPE--CPSGY-TMN-----SS----NLLCTPC LGPCPKVCHLL-EGEKTIDS-----VTS--AQEL-------RGC-----TVINGSLIINI R--GG-N---NLAAELEANLGLIEEISGYLKIR------RSYALVSLSFFRKLRLIRGET LEIG-NYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR QERNDIALKTNGDQASCENELLKFSYIRTSFD---------------------------- ------------------------------------------------KILLRWEPYWP- PDFRDLLGFMLFYKEA-PYQ--NVTEFDGQDACGSNSWTVVDIDPPLRSNDP-KSQNHPG WL---MRGLKPWTQYAIFVKTL-VTFSDE--RRTY------GAKSDIIYVQTDATNPSVP LDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSE-LFELDYCLKGLK----- -LPSRTWSP-PFESEDSQKHNQSE-YEDSAGECCSC----PKTDSQILKEL-EESSFRKT FEDYLHNVVFV------------P----------RP------SRKRRSLGDVGNVTA--- ---A---VPTVAAFPNT----SSTSVP-T-----SP---EEHRPFEKV--VNK-ESLV-- -ISGLRHFTGYRIELQACNQDTP-----------EERCSVAAYVSART------------ --------MPEAKADDIVGP--VTHEIF--ENNVVHLMWQEPKEPNGLIVLYEVSYRRY- -------GD-EE--LHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTY FYVTDYLD-VPSNIAKIIIG-----PLIFVFLFSVVIGSIYL-FL-R--------KRQPD GPL--------------------------------------------------------- ----------------------------GPLY---------------------------- --------------------------------ASSN-PEYLSASD--VFPCS-------- ------VYVPDE--WEVPREKITLLRELGQGSFGMVYEG-NARDII-------------- KGEAETRVAVKT---------VNESASLRERIEFLNEASVMK-----GFTCHHVVRLL-- ---------------GVVSKGQPTLVVMEL-MAHGDLKSYL-RSLRP-EAE--------- ---NNP-GR---------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD FTVKIG-DFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-QPYQGLSNE Q----------------------------------------------------------V LKFV-----MDGG--YLDQPDNCPERVTD-LMRMCWQFNPKMRPTFLEIVNLLKDDLHPS FPEVSFFHSEENKAPESEELEM----EF--EDMENVP----------------------- --------------------------------------------------------YEE- TIPYTQLNGGKKNGGIL------------------------------------------- ------TL--PWSNPS---- >T_nigroviridis_ENSTNIP00000014880 ------------------------------------------------------------ -------------------------------------MRPPTERSRLTLFWALMLALPPA SGPPPQRV--ICGPGIDIGNDISEFRRLENCTVVEGYLQILLIGDKNN-NVNQETFRSLS FPRLTMITDYLLLFRVSGLDSLSTLFPNLTVIRGRNLFYNYALVIFEMTSLKDIGLYSLR NITRGAIRIEKNPELCYLDSVDWSVIMDAEFNNYIAGNKQS-KECSDVCPGVME------ -SSPQCRKTVFNN----NYSYRCWNSNHCQRECPDKCGRRACTADGQCCHPQ-CLGSCTR AGSD---AACAACVHYYHH----GRC-VAQCPPGTYRFEGWRCVSVDFCSK-VH------ -------LPDPHTFVLHGQEC-------MPE--CPSGYTRST-----TD----NMSCTAC DGLCDKVC---EGEEKVIDS-----VDA--AQSL-------KGC-----TVIKGNLHINI R--RGPN---NMVAELESFTGLIQRVKGYVRIR------HSHTLNSLAFLRSLRYIDGET LLDD-MYAFFAFDNHQLQYLWDWSQHNLTIRTGKLYFRANPKLCVSEIHKMWEKTGIQGR FDESDF--RNNGDRASCESTILAFTSNSTSST---------------------------- ------------------------------------------------RIKLTWQRYRP- PDYRDLISFIVYFKEA-PHS--NITEYEGQDGCGSNSWTMVDVELR-----P-DWDADPG VL---LS-LRPWTQYAVFVKAITL-MVEN--KHMP------SAKSKVVYIRTRPSAPSMP QDVRAYSNSSTQLVVRWS-PARPNGNQTYYLVRWQQQAEDKE--YQHNYCSKELK----- -IPIRIAARGVGDQEEDTKPTKPDAEGPQKGPCCPC----PKSAEDLEAEA-ADASYRKV FENFLHNSIFT------------P----------RP-----PDRRRRDVFGAANSSHLRY -------SSAVPPLQAD----ANSSSGA------EPLDRDFDFSEQSV---TE-RELQ-- -ISGLKPFTVYRIDIHACNRQVQ-------------RCSAAEFVFSRT------------ --------KPAEKADDIPGL--LTWEG---HEDWGFLRWPEPRHPNGLVLMYEVKFQLA- -------SE-SE--KHECVSGQSYRTQRGVRLSNLGPGNYSVRVRAISLAGNGSWTHILD LYVAER----YQNILFAMIF----VPLAVVLLICLVVTALVV-LNKK--------RNSDR LGN--------------------------------------------------------- ----------------------------GVLY---------------------------- --------------------------------ASVN-PEYFSAAE--------------- ------MYVPDE--WEVAREKISLSRELGQGSFGMVYEG-LAKGVV-------------- KDEAETRVAIKT---------VNEAASMRERIEFLNEASVMK-----EFNCHHVVRLL-- ---------------GVVSQGQPTLVIMEL-MTRGDLKSYL-RSLRP-EEQ--------- ---QCS-SL---------SLPPLKKMLQMAGQIADGMAYLNANKFVHRDLAARNCMVAED FTVKIGADFGMTRDIYETDYYR-------------------------------------- -------KGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEVATLAE-QPYQGLSNE Q----------------------------------------------------------V LRFV-----MEGG--LLEKPQNCPDMLFE-LMRMCWQYNPKMRPSFVEIISSVKDELEPS FREVSFFYSADNKSSRRAAATL----GRSWTTWTSDLLDTPSSSPCVQPPQTAVRPQTPP PPGSDAP------ASSPSSPCAAAAGADKQPSSQQAAN--GLLGAGPGSEGSARSSLDD- LPPYAHMNGGRKNERAM------------------------------------------- ------PL--PQSSAC---- >T_guttata_ENSTGUP00000017406 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PGYDYVAWRNEST AGGY-VEITFEFDRIRNFTAM-KVHCNNMFAKGVKIFKE-----VQCYF-RADASEWEPS AVSSVLVLDDVNPSARFVTVPLLHRMASAIK----------------------------- ------------------------------------------------------------ -CQYYFADTWMMFSEI-TFQ--SG------------------------------------ -----LWGNHTPTLMF---SAPWPD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AAIMSLCAGWALCPMP---QNPTLKV---------- ---DDS-------NTRILIG----CLVAIIFILVAIIVIILWRQFWQKMLE----KASRR MLD---------------------------DEMTVSLSLPSESSMFNHNR---SSSP--S EQDSPRGRKTQVRART-PSISQP--------PLSSPSFWP---LSKHFVSEGRGHTSPHA AHMKPCGGSGAEGTAVQGRTPMAGLAPR----VPEGVPHYAEADIVNLQGVTGSNTYSVP ALTMDLLAGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLC-EVEGMEKFTGKDFALEGLDG SSDCPVLVAVKM---------LRTDANKNARNDFLKEIKIMS-----RLKDPNIIRLL-- ---------------AVCITDDPLCMITEY-MENGDLNQFL-SRQQA-GGPAAAHAPTQG QAVLLA-PG---------TPGLEPDLRFMATQIASGMKYLSSLNFVHRDLATRNCLVGKH YTIKIA-DFGMSRNLYSGDYYR-------------------------------------- -------IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTLCREQPYSQMSDE Q----------------------------------------------------------V IENTGEFFRDQGRQTYLPQPMLCPDSVYK-LMLSCWRRDTKDRPSFQDIHRLLQDSA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------