10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 --------------------------------------------M--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008285 --------------------------------------------M--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000000286 --------------------------------------------M--------------------------------------------------------------------------- E_caballus_ENSECAP00000012782 --------------------------------------------M--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014260 --------------------------------------------M--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005053 --------------------------------------------M--------------------------------------------------------------------------- B_taurus_ENSBTAP00000028115 --------------------------------------------M--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000007932 --------------------------------------------M--------------------------------------------------------------------------- M_musculus_ENSMUSP00000074471 --------------------------------------------M--------------------------------------------------------------------------- M_domestica_ENSMODP00000023115 --------------------------------------------M--------------------------------------------------------------------------- G_gallus_ENSGALP00000015600 --------------------------------------------M--------------------------------------------------------------------------- T_guttata_ENSTGUP00000006104 --------------------------------------------M--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002933 --------------------------------------------M--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019071 --------------------------------------------M--------------------------------------------------------------------------- O_latipes_ENSORLP00000003907 --------------------------------------------M--------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005326 --------------------------------------------M--------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042842 --------------------------------------------M--------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003553 --------------------------------------------M--------------------------------------------------------------------------- O_anatinus_ENSOANP00000003026 --------------------------------------------M--------------------------------------------------------------------------- C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 --------------------------------------------M--------------------------------------------------------------------------- T_guttata_ENSTGUP00000010778 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358997 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023353 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021407 ------------------------------------------------------------------------------------------------------------------------ C_elegans_K09B11.1 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000535 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000092301 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000218 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007763 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017468 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031192 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000005686 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033769 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000053167 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020448 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000033611 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002966-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008814 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000261233 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021862 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016336 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009429 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000035437 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038647 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015274 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010808 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007783 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000067130 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025212 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000256458 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084549 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007680 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026192 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000033729 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007642-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000055073 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000025500 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011997 -----------------------------------------------------------------------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL O_anatinus_ENSOANP00000021129 ----------------------------------------------------------------------------------KVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL G_gallus_ENSGALP00000020950 -----------------------------------------------------------------------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL B_taurus_ENSBTAP00000029006 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003689 -----------------------------------------------------------------------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL X_tropicalis_ENSXETP00000003054 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000288602 ---MAALSGG-------------------GGGGAEPGQALFNGDMEPEAGAGAG---------------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL P_troglodytes_ENSPTRP00000033866 ---MAALSGG-------------------GGGGAEPGQALFNGDMEPEAGAGAG---------------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL C_familiaris_ENSCAFP00000005841 ----------------------------------------------------------------------------------QVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL P_pygmaeus_ENSPPYP00000020265 ---MAALSGG-------------------GGGGAEPGQSLFNGDMEPE--AGAG---------------AAASSAADPAIPEEVWN-I-RQMIKLTQEHIEALLDKFGGEHN--PPSIYL M_musculus_ENSMUSP00000002487 ---MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPE--AGAG---------------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL R_norvegicus_ENSRNOP00000014604 ---MAALSGGGGSSSGGGGGGGGGGGGG-GGGGAEQGQALFNGDMEPE--AGAG---------------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL A_carolinensis_ENSACAP00000011088 --------------------------------------SLFNGDMEPE----LP---------------PLPAAGGDPAVPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004441 ---EEALC--------------------------------------------------------------------------GNWRTV-FYAFVRKSYCF-------------------- D_melanogaster_FBpp0079568 ---MNKYS-------------------------------------------------------------AFIV--------CISLV----LLFTKKDV------------GSHNVDS--- O_latipes_ENSORLP00000020929 ---MSS------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000078 ---MEHLQ--------------------------------------------------------------------------GAWKTL-SNGFGMKDTAF-------------------- A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGLKDAVF-------------------- H_sapiens_ENSP00000251849 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDAVF-------------------- M_mulatta_ENSMMUP00000009777 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDAVF-------------------- P_pygmaeus_ENSPPYP00000014975 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDAVF-------------------- E_caballus_ENSECAP00000010011 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDAVF-------------------- M_musculus_ENSMUSP00000108571 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGLKDAVF-------------------- C_familiaris_ENSCAFP00000007376 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDTVF-------------------- O_latipes_ENSORLP00000012350 ----------------------------------------------------------------------------------QIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL B_taurus_ENSBTAP00000005930 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDTVF-------------------- M_domestica_ENSMODP00000007826 ---MEHFQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDSVF-------------------- G_gallus_ENSGALP00000007991 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGLKDSVF-------------------- D_rerio_ENSDARP00000048390 ---MAALS------------------------SAESPPPVFNGDTMNRDPERDPGLDELGAGLEPACPGEAAIPECQQGIPEEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL M_domestica_ENSMODP00000011339 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013056 ---MDHIH--------------------------------------------------------------------------GAWKAL-TDGIGLKDSVF-------------------- T_nigroviridis_ENSTNIP00000010036 ---MAALS------------------------SAESPPPVFNGDAAEREPGRERGLEEPGSGFNTAY--TTRIPGGAQN--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPTIYL T_rubripes_ENSTRUP00000029372 ---MAALS------------------------SAESPPPVLNGDAAERDPGRERGLEELDSGFNSAC--TTRVPGGAQN--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPTIYL D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SNGFGFKDAVF-------------------- T_rubripes_ENSTRUP00000016249 ---MEHLQ--------------------------------------------------------------------------GAWKTL-SNGFGMKETEF-------------------- G_aculeatus_ENSGACP00000025456 ---MAALS------------------------SAETQPPVFNGDTAEREPGREQGLEEL----------------GPQD--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL T_nigroviridis_ENSTNIP00000015593 ---AR------------------------------------------------------------------------------AWKTL-SNGFGMKETEF-------------------- T_rubripes_ENSTRUP00000004702 ---M-------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP011710-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014365 ---MEHLQ--------------------------------------------------------------------------GAWRTL-SNGFGMKDSAF-------------------- D_rerio_ENSDARP00000008826 ---M-------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000003552 ---MEHIQ--------------------------------------------------------------------------GAWKTI-SSGFGFKDAVF-------------------- D_rerio_ENSDARP00000071167 ---MS------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000011788 ---M-------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000015921 ---M-------------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000008740 ---M-------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000021561 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 ---M-------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP006219-PA ---MFVCT-------------------------------------------------------------SFLIVHSPTLSLSLSLSPFSRLTFTPSGTAGYARTASAGNGSSSNSYSPNG G_aculeatus_ENSGACP00000018983 ---M-------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015667 ---M-------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000037887 ---M-------------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33E2.2a ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000010512 ---MAAVS-----------------------GGSTEGPSLLNGDLLESETGGLGGAGEM---------------CASGGYPEEVRGPV-RGGFGVSAYLIRWCLYLGGLLYNCVPP---I P_pygmaeus_ENSPPYP00000020565 ---M-------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000095291 ---MEHFQ--------------------------------------------------------------------------GAWKSVSSHGFGCKDSVF-------------------- T_rubripes_ENSTRUP00000007128 ---M-------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000020461 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021875 ---M-------------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000259089 ---M-------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL004592-PA ---M-------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000008303 ---M-------------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020913 ---M-------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000030627 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000020756 AGRM-------------------------------------------------------------------------------------------------------------------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ---------------------------------------------------------------------N----------KPITPSTYVRCLNVGLIRKL-------------------- P_troglodytes_ENSPTRP00000008285 ---------------------------------------------------------------------N----------KPITPSTYVRCLNVGLIRKL-------------------- M_mulatta_ENSMMUP00000000286 ---------------------------------------------------------------------N----------KPITPSTYVRCLNVGLIRKL-------------------- E_caballus_ENSECAP00000012782 ---------------------------------------------------------------------N----------KPITPSTYVRCLNLGLIRKL-------------------- C_familiaris_ENSCAFP00000014260 ---------------------------------------------------------------------N----------KPITSSTYVRCLNLGLIRKL-------------------- P_pygmaeus_ENSPPYP00000005053 ---------------------------------------------------------------------N----------KPITSSTYVRCLNVGLIRKL-------------------- B_taurus_ENSBTAP00000028115 ---------------------------------------------------------------------N----------KPITASTYVRCLSLGLIRKL-------------------- R_norvegicus_ENSRNOP00000007932 ---------------------------------------------------------------------S----------KPLTPSTYVRSLNVGILRKL-------------------- M_musculus_ENSMUSP00000074471 ---------------------------------------------------------------------N----------KPLTPSTYIRNLNVGILRKL-------------------- M_domestica_ENSMODP00000023115 ---------------------------------------------------------------------N----------KTVTSSTYVRCLNVGLIRQL-------------------- G_gallus_ENSGALP00000015600 ---------------------------------------------------------------------S----------QPVTAATYVRSLRYGLLRQL-------------------- T_guttata_ENSTGUP00000006104 ---------------------------------------------------------------------G----------EPVTDSTHVRCLSYGLVRRL-------------------- A_carolinensis_ENSACAP00000002933 ---------------------------------------------------------------------N----------KPITPSTYVRCLGYGMVKQL-------------------- T_nigroviridis_ENSTNIP00000019071 ---------------------------------------------------------------------S----------NSVTSATYIRNLSYSLRRQL-------------------- O_latipes_ENSORLP00000003907 ---------------------------------------------------------------------D----------SSVTSATYVRNISYSLRRKL-------------------- G_aculeatus_ENSGACP00000005326 ---------------------------------------------------------------------N----------NSVTSASYIRNLSYSLRRRL-------------------- T_rubripes_ENSTRUP00000042842 ---------------------------------------------------------------------S----------NSVTSATYIRNLSYSIRRQL-------------------- O_cuniculus_ENSOCUP00000003553 ---------------------------------------------------------------------N----------KPISPSTYVRCLNVGLIRKL-------------------- O_anatinus_ENSOANP00000003026 ---------------------------------------------------------------------S----------KTVTPSTYVRCLNFGLIRQL-------------------- C_intestinalis_ENSCINP00000015329 --------------------------------------------------------------------MSWGWGSFQTPRKQVTAQTYIRNLPYSVLKSI-------------------- X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------MSKTVTPSTYVRNLSHGMHRQL-------------------- D_rerio_ENSDARP00000023777 ---------------------------------------------------------------------S-----------DVTPNTPVRKLRYSALRAL-------------------- T_guttata_ENSTGUP00000010778 ------------------------------------------------------------------------------------PALYIHSMPAWVLEDF-------------------- H_sapiens_ENSP00000358997 ----------------------------------------------------------------------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRF-------------------- P_pygmaeus_ENSPPYP00000023353 ----------------------------------------------------------------------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRF-------------------- B_taurus_ENSBTAP00000021407 ------------------------------------------------------------------------------------------------------------------------ C_elegans_K09B11.1 ----------------------------------------------------------------------------MDDSLGVSEVVMIPFMKREVLQQI-------------------- C_familiaris_ENSCAFP00000000535 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000092301 ---------------------------------------------------------------------------------------LLYNLSASVMNDF-------------------- G_gorilla_ENSGGOP00000000218 ----------------------------------------------------------------------MAGGPGPGESAAPGAQHFLYEVPPWVMCRF-------------------- E_caballus_ENSECAP00000007763 ------------------------------------------------------------------------------------------------MCRF-------------------- M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017468 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031192 ------------------------------------------------------------------------------MSRGSFEEEFLYRVPSQVMYRF-------------------- R_norvegicus_ENSRNOP00000005686 ------------------------------------------------------------------------MAGPCGARGTLSPHSLLFDLPPALLGEL-------------------- M_musculus_ENSMUSP00000033769 ----------------------------------------------------------------------MAGGPGPGEPVVPGAQHFLYEVPPWVMCRF-------------------- G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------MSAGDQRSTFLYKLPPPVLWEF-------------------- A_carolinensis_ENSACAP00000012253 ---------------------------------------------------------------------------------------FLYELPASVMCHF-------------------- M_domestica_ENSMODP00000037830 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000053167 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020448 ------------------------------------------------------------------------MAGRCGARGALSPQLLLFDLPPALLGEL-------------------- B_taurus_ENSBTAP00000033611 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002966-PA --------------------------------------------------CMLCPIMSKPNGQHTEMEGKPSGLSAATTVAPLSNFVYIYDIPRMEKKRL-------------------- C_familiaris_ENSCAFP00000028744 ----------------------------------------------------------------------MAGGPGPGDPAAPGAQHFLYEVPPWVMCRF-------------------- P_troglodytes_ENSPTRP00000008814 ------------------------------------------------------------------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- H_sapiens_ENSP00000261233 ------------------------------------------------------------------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- M_mulatta_ENSMMUP00000021862 ------------------------------------------------------------------------MAGNCGVRGALSAHTLLFDLPPALLGEL-------------------- T_rubripes_ENSTRUP00000016336 ----------------------------------------------------------------LTGLGPDCGHTQRPQSG----DQFLYDLPPRVLWEF-------------------- A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009429 -----------------------------------------------------------------------------GSSGPVPAGTALLDLPPLLLGRL-------------------- G_gallus_ENSGALP00000035437 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038647 ----------------------------------------------------------------------MAGGPGP------------------------------------------- P_pygmaeus_ENSPPYP00000015274 ------------------------------------------------------------------------------------MACYIYQLPSWVLDDL-------------------- E_caballus_ENSECAP00000010808 ------------------------------------------------------------------------------------MSCYIYQLPSWVVDDL-------------------- T_nigroviridis_ENSTNIP00000007783 ---------------------------------------------------------------------PGPGQTNIQLVGLPDWELFLYELPSAVYWDF-------------------- D_rerio_ENSDARP00000067130 --------------------------------------------------VESSSSSVSERGMKHPNIITFTPGSTRNMSGNTEPSTLLFDVPPVLMESF-------------------- P_troglodytes_ENSPTRP00000025212 ------------------------------------------------------------------------------------MACYIYQLPSWVLDDL-------------------- H_sapiens_ENSP00000256458 ------------------------------------------------------------------------------------MACYIYQLPSWVLDDL-------------------- D_melanogaster_FBpp0084549 -------------------------------------------------------MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQL-------------------- C_familiaris_ENSCAFP00000007680 ------------------------------------------------------------------------------------MSCYIYQLPAWVLDDL-------------------- M_mulatta_ENSMMUP00000026192 ------------------------------------------------------------------------------------MACYIYQLPSWVLDDL-------------------- M_domestica_ENSMODP00000033729 ------------------------------------------------------------------------------------TTQYIYQLPSWVLEDF-------------------- A_aegypti_AAEL007642-PA ----------------------------------------------------------MTPYTRSTEVRKVFELDELASVLEDDWRTLFYLIPRKIADVERPAGSYPIRYNGTH------ T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ------------------------------------------------------------------------------------MSCYIYQLPSWVLDDL-------------------- M_musculus_ENSMUSP00000055073 ------------------------------------------------------------------------------------MACYIYQLPSWVLDDL-------------------- A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ------------------------------------------------------------------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- G_aculeatus_ENSGACP00000025500 ----------------------------------------------------------------------------------MDPNTFLYDVPPVVIERL-------------------- T_guttata_ENSTGUP00000011997 E--AYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTDTVA------SSSSSSLSVAPSSLSVYQNPADMSRNNPKSPQKPIVRVFLPNKQRTV--------------------- O_anatinus_ENSOANP00000021129 E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLSVAPSSLSVFQNPTDAARGNPKSPQKPIVRVFLPNKQRTV--------------------- G_gallus_ENSGALP00000020950 E--AYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTDTVA------SSSSSSLSVAPSSLSVYQNPTDMSRNNPKSPQKPIVRVFLPNKQRTV--------------------- B_taurus_ENSBTAP00000029006 ---AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTV--------------------- E_caballus_ENSECAP00000003689 E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTV--------------------- X_tropicalis_ENSXETP00000003054 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000288602 E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASMDTVT------SSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- P_troglodytes_ENSPTRP00000033866 E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASMDTVT------SSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- C_familiaris_ENSCAFP00000005841 E--AYEEYTSKLDALQQREQQLLESL-----------------------------------------VFQNPTDISRSNPKSPQKPIVRVFLPNKQRTV--------------------- P_pygmaeus_ENSPPYP00000020265 E--AYEEYTSKLDALQQREQQFLESLGNGTDF--SVSSSASMDTVT------SSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- M_musculus_ENSMUSP00000002487 E--AYEEYTSKLDALQQREQQLLESL-----------------------------------------VFQTPTDASRNNPKSPQKPIVRVFLPNKQRTV--------------------- R_norvegicus_ENSRNOP00000014604 E--AYEEYTSKLDALQQREQQLLESL-----------------------------------------VFQTPTDVSRNNPKSPQKPIVRVFLPNKQRTV--------------------- A_carolinensis_ENSACAP00000011088 EAKAYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTETVA------SSSSSSLSVAPSSLSVYQNPTDLSRNNPKSPQKPTVRVFLPNKQRTV--------------------- T_nigroviridis_ENSTNIP00000000196 ----------------------------------------------------------------------------------RGGGTIRVYLPNKQRTV--------------------- T_rubripes_ENSTRUP00000004441 ----------------------------------------------------DCKTYIYPL------LNVDSQRETSPEDIPRGGGTIRVYLPNKQRTV--------------------- D_melanogaster_FBpp0079568 ---------RIYGFQQ---------SSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVS O_latipes_ENSORLP00000020929 -----------------------------------------------------------TS------SSYSSSGETSPEDVPRGGGTIRVYLPNKQRTV--------------------- O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000078 ----------------------------------------------------EGP-CLSPTLVQGFSCQRRSSDDGKMPD-SKTSSTIRVYLPNQQRTV--------------------- A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- H_sapiens_ENSP00000251849 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- M_mulatta_ENSMMUP00000009777 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- P_pygmaeus_ENSPPYP00000014975 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- E_caballus_ENSECAP00000010011 ----------------------------------------------------DGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- M_musculus_ENSMUSP00000108571 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- C_familiaris_ENSCAFP00000007376 ----------------------------------------------------DGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- O_latipes_ENSORLP00000012350 E--AYEEYTSKLDALQQREQQLLEAMGNGGDF-CSPSPVPALLEVKMGSLGVGGGVQSFASAPNSLAVLQTPTDAVRGNPRSPQKPIVRVFLPNKQRTV--------------------- B_taurus_ENSBTAP00000005930 ----------------------------------------------------DGTSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- M_domestica_ENSMODP00000007826 ----------------------------------------------------DGSGCISPTLVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- G_gallus_ENSGALP00000007991 ----------------------------------------------------DGPNCISPTIVQQFGYQRRASDDGKISDTSKTSNTIRVFLPNKQRTV--------------------- D_rerio_ENSDARP00000048390 E--AYEEYTSKLDALQQREQQLLEAIGNGTEF--CSSPTPTLLDVK------GQGIQSAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV--------------------- M_domestica_ENSMODP00000011339 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004834 ---------------------------------------------------------ACPV------SSCRSSGETSPEDVPRGGGTIRVYLPNKQRTV--------------------- A_carolinensis_ENSACAP00000013056 ----------------------------------------------------NGSSCISPTIVQQFGYQRRASDDGKLSDSSKTSNTIRVFLPNKQRTV--------------------- T_nigroviridis_ENSTNIP00000010036 E--AYEEYTSKLDALQQREQQLLEAMGNGADFPCSPSPMPALLEVKMGGCGIGGGAQ----TPSSLAVLQTPIDGNRINPRSPQKPIVRVFLPNKQRTV--------------------- T_rubripes_ENSTRUP00000029372 E--AYEEYTSKLDALQQREQQLLEAMGNGTDFPCSPSPMPALLEVKMGGCVPGVGAQ----APNSLAVLQTPTDGSRVNPRSPQKPIVRVFLPNKQRTV--------------------- D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 ----------------------------------------------------DGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- T_rubripes_ENSTRUP00000016249 -----------------------------------------------------DSPCLSPTMVQGYPCQRRSSDDSKMPD-SKTSSTIRVYLPNQQRTVVSGFGLRCAETKVP--RGIKD G_aculeatus_ENSGACP00000025456 E--AYEEYTSKLDALQQREQQLLEAMGNGTDFSCSPSPMPALLEVMSGGCGVAGGAQAFPSAPNTLAVLQTPTDAGRANPRSPQKPIVRVFLPNKQRTV--------------------- T_nigroviridis_ENSTNIP00000015593 -----------------------------------------------------DSPCLSPTMVQGFPCQRRSSDDGKMPD-SKTSSTIRVYLPNQQRTV--------------------- T_rubripes_ENSTRUP00000004702 ------------------------------------GCMKSTLCES-----------LGSGLE-----RKNSPQTVGAEQRHYVRD------PTFEAKHNF------------------- A_gambiae_AGAP011710-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014365 -----------------------------------------------------EGPCLSPTMVQGFPSQRRSSNDSRTPN-SKASSTIRVYLPNQQRTVVSSI----AQNFMPISRTLKS D_rerio_ENSDARP00000008826 ------------------------------------GCACSDQNHPK---------------------GHEHYNSTNSKTSHASRD---------------------------------- E_caballus_ENSECAP00000003552 ----------------------------------------------------DGPSCICPTIVQQFGYQRRASDDGKLTDSSKTSNTICVFLPNKQRTV--------------------- D_rerio_ENSDARP00000071167 -----------------------------------------------------------NT------SSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV--------------------- C_familiaris_ENSCAFP00000011788 ------------------------------------GVGSSK-----------------KQVK-----EKEKGQWSPVKVSTQSKD------PPPLPP---------------------- O_latipes_ENSORLP00000015921 ------------------------------------GCIKSILIGE-----------LTNGVE-----EKGSQQAAQTDQAHYVRD------PTSTSKSTR------------------- O_anatinus_ENSOANP00000008740 ------------------------------------GCIKSKRKDNL----------NDDGID-----LKSQP-VRNTDRTIYVRD------PTSNKQQRPV------------------ O_latipes_ENSORLP00000021561 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 ------------------------------------GCIKSKRKHSS----------THDGID-----LKTQP-VRNTDRTIYVRD------PTNKQQRPLPE----------------- A_gambiae_AGAP006219-PA KFKRRKKTEKLHQQQQQDALEEDTIEPGVCQVYTGTTCEQYLRNQTVFVTPDITMEILEERLKSAYGVIRESKDMNANCRVYALPSLCYSILPVCRTPELTNHQYFANRAAAEAAQRAAT G_aculeatus_ENSGACP00000018983 ------------------------------------GCMKSRLTDG-----------LSGGVE-----GKTGEQTVHTDRMDFVKD------PTSNRTSNC------------------- C_familiaris_ENSCAFP00000015667 ------------------------------------GCSCSSNPEDDWMENIDVCENCHYPIV-----PLDGKATLPMRNGSDVRD------PL-------------------------- B_taurus_ENSBTAP00000037887 ------------------------------------GCSCSSNPEDDWMENIDVCENCHYPIV-----PLDGKTTLPMRNGSEVRD------PL-------------------------- M_musculus_ENSMUSP00000100967 -------------------------------------MARRSSRVSWLAFEGWESRDLPRVSPRLFGAWHPAPAAARMPTQRWAPGTQCMTKCENSRPKP-------------------- R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------SQQRWAPGTQCMTKCENSRPKP-------------------- C_elegans_F33E2.2a ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA -------------------------------------------------------------------MYGKSDLSCASCYNAIEKDGYIGALGQEWHTDC-------------------- X_tropicalis_ENSXETP00000010512 Q--AYEEYTSKLDLLQQREQQLLESMGNGTD-----STSLPSELTL------SSVPSNLSLAPSALSALRTPSDPSRINPKSPQKPIVRVFLPNKQRTV--------------------- P_pygmaeus_ENSPPYP00000020565 ------------------------------------GLVSSKKPDKE------------KPIK-----EKDKGRWSPLKVSAQDKE------PPPLPP---------------------- D_rerio_ENSDARP00000095291 -----------------------------------------------------EDSCMSPSILKTFP-YRRLSDDGRIPD-SKTSSTIRVFLPNKQRTV--------------------- T_rubripes_ENSTRUP00000007128 ------------------------------------GCIKSKEEKG-----------PTMKYRPENSMMADPNATAASQTGHYGPD------PTQLQQNQVPSSSSGNVGVNFNHSITPF O_latipes_ENSORLP00000020461 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021875 ------------------------------------GCACSTDSEEWLENLDDICEHCNCPIP-----PQSSKGKLSIYTDQLIQH------P--------------------------- C_intestinalis_ENSCINP00000011940 -------------------------------------------------------------------------------SSVSIPDRPAPPIPTPVSIR--------------------- H_sapiens_ENSP00000259089 ------------------------------------GLVSSKKPDKE------------KPIK-----EKDKGQWSPLKVSAQDKD------APPLPP---------------------- A_aegypti_AAEL004592-PA ----------------------------------GNKCCSKRQDQELALSYPGGYKKGENSFTSNMSGPKHSNGGGGSLDSRYTPD------PNRGQL---------------------I T_rubripes_ENSTRUP00000008303 ------------------------------------GCVQCKDKKA-----------TKLTD------NRETNHSLGAARYHYGAD------P---MPQHYPSFGVTAIPNYNNFHTPVG X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ---------------------------------------------------------CHYPIV-----PLDGKGKLPIRNGSEVRD------PL-------------------------- E_caballus_ENSECAP00000020913 ------------------------------------GCSCSSNPEDDWMENIDVCENCHYPIV-----PLDGKATLPMRNGSEVRD------PL-------------------------- T_rubripes_ENSTRUP00000030627 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000020756 ------------------------------------GCIKSRLDGG-----------VSKGVE-----EKSSPQTVRTQLARYVRD------PTSDINHNI------------------- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- P_troglodytes_ENSPTRP00000008285 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- M_mulatta_ENSMMUP00000000286 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- E_caballus_ENSECAP00000012782 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- C_familiaris_ENSCAFP00000014260 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- P_pygmaeus_ENSPPYP00000005053 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- B_taurus_ENSBTAP00000028115 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- R_norvegicus_ENSRNOP00000007932 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- M_musculus_ENSMUSP00000074471 ---------------------------------------------------------------------------------------------------SDFID---PQEGWKKL----- M_domestica_ENSMODP00000023115 ---------------------------------------------------------------------------------------------------ADFID---PQEGWKKL----- G_gallus_ENSGALP00000015600 ---------------------------------------------------------------------------------------------------ADLLD---PQEGWKRL----- T_guttata_ENSTGUP00000006104 ---------------------------------------------------------------------------------------------------ADFID---PQEGWKKL----- A_carolinensis_ENSACAP00000002933 ---------------------------------------------------------------------------------------------------ADFID---PQEGWKKL----- T_nigroviridis_ENSTNIP00000019071 ---------------------------------------------------------------------------------------------------SDILD---PQERWKEI----- O_latipes_ENSORLP00000003907 ---------------------------------------------------------------------------------------------------SDCLD---PYETWRDL----- G_aculeatus_ENSGACP00000005326 ---------------------------------------------------------------------------------------------------SDFLD---PQDRWMEV----- T_rubripes_ENSTRUP00000042842 ---------------------------------------------------------------------------------------------------SGILD---PQERWKEI----- O_cuniculus_ENSOCUP00000003553 ---------------------------------------------------------------------------------------------------SDFMD---PQEGWKKL----- O_anatinus_ENSOANP00000003026 ---------------------------------------------------------------------------------------------------ADFID---PQEGWKKL----- C_intestinalis_ENSCINP00000015329 ---------------------------------------------------------------------------------------------------ADDLDTAGTATNWRDF----- X_tropicalis_ENSXETP00000014885 ---------------------------------------------------------------------------------------------------ADLLD---PQEGWKKI----- D_rerio_ENSDARP00000023777 ---------------------------------------------------------------------------------------------------ADLLD---PQDTWRSI----- T_guttata_ENSTGUP00000010778 ---------------------------------------------------------------------------------------------------CQKMDCL-SDYDWMRF----- H_sapiens_ENSP00000358997 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWCQF----- P_pygmaeus_ENSPPYP00000023353 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWCQF----- B_taurus_ENSBTAP00000021407 ------------------------------------------------------------------------------------------------------------------------ C_elegans_K09B11.1 ---------------------------------------------------------------------------------------------------CAILD---TDNTWETI----- C_familiaris_ENSCAFP00000000535 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000092301 ---------------------------------------------------------------------------------------------------TRVMDSL-SNSDWISF----- G_gorilla_ENSGGOP00000000218 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWXXX----- E_caballus_ENSECAP00000007763 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWCQF----- M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017468 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031192 ---------------------------------------------------------------------------------------------------FHIMDSL-EETDWKKF----- R_norvegicus_ENSRNOP00000005686 ---------------------------------------------------------------------------------------------------CTILDSCDGPLGWRGL----- M_musculus_ENSMUSP00000033769 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWCQF----- G_aculeatus_ENSGACP00000001480 ---------------------------------------------------------------------------------------------------CLVMDGL-SDLDWTRFVE--- A_carolinensis_ENSACAP00000012253 ---------------------------------------------------------------------------------------------------YEIMDAL-GREEWQRF----- M_domestica_ENSMODP00000037830 ------------------------------------------------------------------------------------------------------MDSL-ESADWHKF----- R_norvegicus_ENSRNOP00000053167 ------------------------------------------------------------------------------------------------------MDAL-EPADWCQF----- M_musculus_ENSMUSP00000020448 ---------------------------------------------------------------------------------------------------CGILDSCDGPLGWRGL----- B_taurus_ENSBTAP00000033611 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP002966-PA ---------------------------------------------------------------------------------------------------AALLE---VNNKWYEL----- C_familiaris_ENSCAFP00000028744 ---------------------------------------------------------------------------------------------------YKVMDAL-EPADWCQFGGWRR P_troglodytes_ENSPTRP00000008814 ---------------------------------------------------------------------------------------------------CAVLDSCDGALGWRGL----- H_sapiens_ENSP00000261233 ---------------------------------------------------------------------------------------------------CAVLDSCDGALGWRGL----- M_mulatta_ENSMMUP00000021862 ---------------------------------------------------------------------------------------------------CAVLDSCDGALGWRGL----- T_rubripes_ENSTRUP00000016336 ---------------------------------------------------------------------------------------------------CRVMDAL-SDLDWTRF----- A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009429 ---------------------------------------------------------------------------------------------------CALLDGAHGPLGWRDL----- G_gallus_ENSGALP00000035437 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038647 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000015274 ---------------------------------------------------------------------------------------------------CRNMDAL-SEWDWMEF----- E_caballus_ENSECAP00000010808 ---------------------------------------------------------------------------------------------------CRNMDTL-SEWDWMHF----- T_nigroviridis_ENSTNIP00000007783 ---------------------------------------------------------------------------------------------------CRVMDTL-SDLDWTRF----- D_rerio_ENSDARP00000067130 ---------------------------------------------------------------------------------------------------CRLMDSGVDGLGWRTL----- P_troglodytes_ENSPTRP00000025212 ---------------------------------------------------------------------------------------------------CRNMDAL-SEWDWMEF----- H_sapiens_ENSP00000256458 ---------------------------------------------------------------------------------------------------CRNMDAL-SEWDWMEF----- D_melanogaster_FBpp0084549 ---------------------------------------------------------------------------------------------------CAHLDAL---DVWQQL----- C_familiaris_ENSCAFP00000007680 ---------------------------------------------------------------------------------------------------CRNMDTL-SEWDWMQF----- M_mulatta_ENSMMUP00000026192 ---------------------------------------------------------------------------------------------------CRNMDTL-SEWDWMEF----- M_domestica_ENSMODP00000033729 ---------------------------------------------------------------------------------------------------CHKMDSL-SEWDWMQF----- A_aegypti_AAEL007642-PA ---------------------------------------------------------------------------------------------------ESELDDYGRIQNTARARILLE T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ---------------------------------------------------------------------------------------------------CRNMDTL-SEWDWMQF----- M_musculus_ENSMUSP00000055073 ---------------------------------------------------------------------------------------------------CRNIDTL-SEWDWMQF----- A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ---------------------------------------------------------------------------------------------------CAVLDSCDGALGWRGL----- G_aculeatus_ENSGACP00000025500 ---------------------------------------------------------------------------------------------------CQILDSGVDRLGWRAL----- T_guttata_ENSTGUP00000011997 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- O_anatinus_ENSOANP00000021129 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- G_gallus_ENSGALP00000020950 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- B_taurus_ENSBTAP00000029006 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- E_caballus_ENSECAP00000003689 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- X_tropicalis_ENSXETP00000003054 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000288602 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- P_troglodytes_ENSPTRP00000033866 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- C_familiaris_ENSCAFP00000005841 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- P_pygmaeus_ENSPPYP00000020265 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- M_musculus_ENSMUSP00000002487 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- R_norvegicus_ENSRNOP00000014604 -----VPARCG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- A_carolinensis_ENSACAP00000011088 -----VPARCG----------------------------------------------------------------------------------------VTVRESLKKALMMRGLI---- T_nigroviridis_ENSTNIP00000000196 -----VNVRQG----------------------------------------------------------------------------------------QTVHESLDKALKVRGLS---- T_rubripes_ENSTRUP00000004441 -----VNVRQG----------------------------------------------------------------------------------------QTVHESLDKALKVRGLN---- D_melanogaster_FBpp0079568 IRRKRTKSKDIKN-----------ISIFKKKSTIYEDVFSTDISSK-----------------------------------------------------YPPTRESENLKRICREECELL O_latipes_ENSORLP00000020929 -----VNVRQG----------------------------------------------------------------------------------------QTVYESLDKALKVRGLS---- O_cuniculus_ENSOCUP00000012185 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- G_aculeatus_ENSGACP00000000078 -----VNVRPG----------------------------------------------------------------------------------------MTLYSCLIKALKVRGLQ---- A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- H_sapiens_ENSP00000251849 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- M_mulatta_ENSMMUP00000009777 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- P_pygmaeus_ENSPPYP00000014975 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- E_caballus_ENSECAP00000010011 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- M_musculus_ENSMUSP00000108571 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- C_familiaris_ENSCAFP00000007376 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- O_latipes_ENSORLP00000012350 -----VPARCG----------------------------------------------------------------------------------------MTVRDSLKKALMMRGLI---- B_taurus_ENSBTAP00000005930 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- M_domestica_ENSMODP00000007826 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- G_gallus_ENSGALP00000007991 -----VNVRNG----------------------------------------------------------------------------------------MTLHDCLMKALKVRGLQ---- D_rerio_ENSDARP00000048390 -----VPARCG----------------------------------------------------------------------------------------MTVRDSLKKALMMRGLI---- M_domestica_ENSMODP00000011339 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000004834 -----VNVRQG----------------------------------------------------------------------------------------QTVYESLDKALKVRGLS---- A_carolinensis_ENSACAP00000013056 -----VNVRNG----------------------------------------------------------------------------------------MTLHDCLMKALKVRGLQ---- T_nigroviridis_ENSTNIP00000010036 -----VSARCG----------------------------------------------------------------------------------------MTVRDSLKKALTMRGLI---- T_rubripes_ENSTRUP00000029372 -----VSARCG----------------------------------------------------------------------------------------MTVRDSLKKALTMRGLI---- D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 -----VNVRNG----------------------------------------------------------------------------------------MSLHDCLMKALKVRGLQ---- T_rubripes_ENSTRUP00000016249 VFVHQVNVRPG----------------------------------------------------------------------------------------MTLHSCLIKALKVRGLQ---- G_aculeatus_ENSGACP00000025456 -----VPARCG----------------------------------------------------------------------------------------MTVRDSLKKALMMRGLI---- T_nigroviridis_ENSTNIP00000015593 -----VNVRPG----------------------------------------------------------------------------------------MTLHSCLIKALKVRGLQ---- T_rubripes_ENSTRUP00000004702 ---------------------------------------------------------------------------------------------------LSQNSSLLPGQRFQTMEDKV- A_gambiae_AGAP011710-PA --------------------------------------------------------------------------------------------------RCSVCDARLSSWYFEKDGLLFC O_latipes_ENSORLP00000014365 TSKTVVNVRPG----------------------------------------------------------------------------------------MTLFNCLIKALKVRGLQ---- D_rerio_ENSDARP00000008826 -------------------------------------------------------------------------------------------------------------HKKQNNNQDE- E_caballus_ENSECAP00000003552 -----VSVRNG----------------------------------------------------------------------------------------VSLHDCLMKALKVRGLQ---- D_rerio_ENSDARP00000071167 -----VNVRPG----------------------------------------------------------------------------------------QTVYDSLDKALKVRGLS---- C_familiaris_ENSCAFP00000011788 ---------------------------------------------------------------------------------------------------LILFNHLTPAPPDACLDQEE- O_latipes_ENSORLP00000015921 ---------------------------------------------------------------------------------------------------LK-SNSLLPGQVFQKLEEENK O_anatinus_ENSOANP00000008740 ---------------------------------------------------------------------------------------------------LCSDSHLLPGQRFQSKDPEE- O_latipes_ENSORLP00000021561 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 ---------------------------------------------------------------------------------------------------YHLYSDLLPGQRFQSNDSEE- A_gambiae_AGAP006219-PA IGRGKMRAHEKKNNRKQLLRGNGTLTTTERLRVYFSGGVTPDLGGRFFDGEIVTENSLPPRYDNARRGRRAAGHQQYVQPGEEITVLSYTSSSSGPKKSYPPTRNTENLRRICRNDCELL G_aculeatus_ENSGACP00000018983 ---------------------------------------------------------------------------------------------------AP-DNFLLPGQRFQKREEQSG C_familiaris_ENSCAFP00000015667 ---------------------------------------------------------------------------------------------------VIYEGSNPPASPLQD------ B_taurus_ENSBTAP00000037887 ---------------------------------------------------------------------------------------------------VTYEGSNPPASPLQD------ M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33E2.2a ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA -------------------------------------------------------------------------------------------------FRCSVCDSHLSSWYFEKEGLLFC X_tropicalis_ENSXETP00000010512 -----VPARSG----------------------------------------------------------------------------------------VTVRDSLKKALMMRGLI---- P_pygmaeus_ENSPPYP00000020565 ---------------------------------------------------------------------------------------------------LVVFNHLTPPPPDEHLDEDE- D_rerio_ENSDARP00000095291 -----VNVRAG----------------------------------------------------------------------------------------MTLRNCLIKALKVRGLQ---- T_rubripes_ENSTRUP00000007128 GGSSSAMTPF-----------------------------------------------------------------------------------------GGVSSSFTGPVSNSFSGAVSS O_latipes_ENSORLP00000020461 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021875 ------------------------------------------------------------------------------------------------------SSHSPPLSPLPD------ C_intestinalis_ENSCINP00000011940 -------------------------------------------------------------------------------------------------------------------EPVHQ H_sapiens_ENSP00000259089 ---------------------------------------------------------------------------------------------------LVVFNHLTPPPPDEHLDEDK- A_aegypti_AAEL004592-PA KGIPKGGVDII----------------------------------------------------------------------------------------RPRTTPLHPGLSTR------- T_rubripes_ENSTRUP00000008303 QGMAVFG--------------------------------------------------------------------------------------------GVSTSSHSGTLRTHSGTGLAK X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ---------------------------------------------------------------------------------------------------VTYEGCNPPASPLQD------ E_caballus_ENSECAP00000020913 ---------------------------------------------------------------------------------------------------VTYEGSNPPASPLQD------ T_rubripes_ENSTRUP00000030627 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------------------------------------------------NNSLLPGQRFQTLEEKG- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ P_troglodytes_ENSPTRP00000008285 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ M_mulatta_ENSMMUP00000000286 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ E_caballus_ENSECAP00000012782 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ C_familiaris_ENSCAFP00000014260 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ P_pygmaeus_ENSPPYP00000005053 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ B_taurus_ENSBTAP00000028115 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQI---GKSPTCELLFD------------------------------ R_norvegicus_ENSRNOP00000007932 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ M_musculus_ENSMUSP00000074471 ----------------------AVAIKKP-------------------------SG--DDRYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ M_domestica_ENSMODP00000023115 ----------------------AVDIKKP-------------------------SG--ENRYNQFHIRRFEGLLQN---GKSPTSELLFD------------------------------ G_gallus_ENSGALP00000015600 ----------------------AAAITDP-------------------------AG--DSRYSQAHIRRFEAFVQM---GKSPTCELLYD------------------------------ T_guttata_ENSTGUP00000006104 ----------------------AVDITNP-------------------------SG--ESRYSQVHIRRFEAFVQM---GKSPTCELLYD------------------------------ A_carolinensis_ENSACAP00000002933 ----------------------AVDIKNP-------------------------SG--DNRYNQMHLRRFEARQQV---GKSPTCELLHD------------------------------ T_nigroviridis_ENSTNIP00000019071 ----------------------IVSIRKP-------------------------NG--DFRYSQHHVRRFAGLPAQ---GKSPTEELLAD------------------------------ O_latipes_ENSORLP00000003907 ----------------------IVALRKP-------------------------NG--EPRYTQHHVRRFEGLVAQ---GKSVTVELLND------------------------------ G_aculeatus_ENSGACP00000005326 ----------------------LTSIRKP-------------------------SG--EPRYSQLHVRRFEGLAAQ---GKSPTVELLVD------------------------------ T_rubripes_ENSTRUP00000042842 ----------------------IISIRKP-------------------------NG--DFRYSQHNVRRFAGLVAQ---GKSPTEELLAD------------------------------ O_cuniculus_ENSOCUP00000003553 ----------------------AAAIKKP-------------------------SE--DDRYNQLHIRRFEALLQT---GKSPTCELLFD------------------------------ O_anatinus_ENSOANP00000003026 ----------------------AVDIKKP-------------------------SG--ESKYNQLHIRRFEGLIQM---GKSPTCELLFD------------------------------ C_intestinalis_ENSCINP00000015329 ----------------------VLKIPRG-------------------------PNDPEPRYQLQDIRKFEMIAGR---GDSPTTAAIDA------------------------------ X_tropicalis_ENSXETP00000014885 ----------------------AVNIMKP-------------------------SG--DARYSQFHIRRFEGTVQM---GKSPTCELLYD------------------------------ D_rerio_ENSDARP00000023777 ----------------------MADISRA-------------------------CG--EPRYTQMHMRRFEACVLQ---GKSPTMELLFD------------------------------ T_guttata_ENSTGUP00000010778 ----------------------ASYVITD----------------------------------QTELRKIKCMEKT---GISITRELMWW------------------------------ H_sapiens_ENSP00000358997 ----------------------AALIVRD----------------------------------QTELRLC---ER----SGQRTASVLWP------------------------------ P_pygmaeus_ENSPPYP00000023353 ----------------------AALIVRD----------------------------------QTELRLC---ER----SGQRTASVLWP------------------------------ B_taurus_ENSBTAP00000021407 ----------------------AALIVRD----------------------------------QTELRLC---ER----SGQRTASVLWP------------------------------ C_elegans_K09B11.1 ----------------------APYMP------------------------------------GIELRDVEGCKRYSSYNQSPSELLLRI------------------------------ C_familiaris_ENSCAFP00000000535 ----------------------AERLLSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ D_rerio_ENSDARP00000092301 ----------------------ASQIISD----------------------------------QTELRLL---EQ----SPRRTSNLMHN------------------------------ G_gorilla_ENSGGOP00000000218 ----------------------XXXXXXX----------------------------------XXXXXXX---XX----XXXXXXXXXXX------------------------------ E_caballus_ENSECAP00000007763 ----------------------AALIVRD----------------------------------QTELRLC---ER----S-QRTASV-WP------------------------------ M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000017468 ----------------------ASLIVRD----------------------------------QTELRLH---ER----TPARTASIMWP------------------------------ X_tropicalis_ENSXETP00000031192 ----------------------ASMIIPD----------------------------------MTELRLL---EQQG--SRSRTEEVVWA------------------------------ R_norvegicus_ENSRNOP00000005686 ----------------------AERLSNS----------------------------------WLDVRHIEKYVHQ---GKSGTRELLWS------------------------------ M_musculus_ENSMUSP00000033769 ----------------------AALIVRD----------------------------------QTELRLC---ER----SEQRTASVLWP------------------------------ G_aculeatus_ENSGACP00000001480 ----------------------ASEVLGD----------------------------------QTAVRLA---EK----RERRTDWVMNQ------------------------------ A_carolinensis_ENSACAP00000012253 ----------------------ASRIVRD----------------------------------QVELRLY---ER----MEAPTSKVMWA------------------------------ M_domestica_ENSMODP00000037830 ----------------------ASLIVQD----------------------------------QTELRLG---ER----FHDRTARIMWS------------------------------ R_norvegicus_ENSRNOP00000053167 ----------------------AALIVRD----------------------------------QTELRLC---ER----SEQRTASVLWP------------------------------ M_musculus_ENSMUSP00000020448 ----------------------AERLSNS----------------------------------WLDVRHIEKYVNQ---GKSGTRELLWS------------------------------ B_taurus_ENSBTAP00000033611 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ A_gambiae_AGAP002966-PA -------------------------------------------------------GEKQMGYSTVELDSTQRCCQRN--NRSPAEQLLDK------------------------------ C_familiaris_ENSCAFP00000028744 AGDAGAGGARAPGAGPDACRPAAALIVRD----------------------------------QTELRLC---ER----SGQRTASVLWP------------------------------ P_troglodytes_ENSPTRP00000008814 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ H_sapiens_ENSP00000261233 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ M_mulatta_ENSMMUP00000021862 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ T_rubripes_ENSTRUP00000016336 ----------------------ASMVLDD----------------------------------QTALRLA---QK----QEKRTDWVMNQ------------------------------ A_gambiae_AGAP003062-PA ---------------------------------------------------------------MLSMLGSDGSTSDTLGSESSSSAIVPQ------------------------------ P_pygmaeus_ENSPPYP00000005399 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ O_anatinus_ENSOANP00000009429 ----------------------AERLSSN----------------------------------WLEVRHFEKYVQQ---GRSGTRELLWS------------------------------ G_gallus_ENSGALP00000035437 ----------------------ASYVITD----------------------------------QTELRKIKCMEKT---GISITRELMWW------------------------------ P_troglodytes_ENSPTRP00000038647 ----------------------------------------------------------------TELRLC---ER----SGQRTASVLWP------------------------------ P_pygmaeus_ENSPPYP00000015274 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ E_caballus_ENSECAP00000010808 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITREVLWW------------------------------ T_nigroviridis_ENSTNIP00000007783 ----------------------ASLVLDD----------------------------------QTALRLA---EK----QAHAPDWVMNR------------------------------ D_rerio_ENSDARP00000067130 ----------------------ASRILSS----------------------------------QLEVRCIEMYAVA---GKSPTKELMWS------------------------------ P_troglodytes_ENSPTRP00000025212 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ H_sapiens_ENSP00000256458 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ D_melanogaster_FBpp0084549 ----------------------ATAVKLY----------------------------------PDQVEQISSQKQR---GRSASNEFLNI------------------------------ C_familiaris_ENSCAFP00000007680 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ M_mulatta_ENSMMUP00000026192 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ M_domestica_ENSMODP00000033729 ----------------------ASYVMTD----------------------------------QTQLRKIKSMERIQ--GVSITRELLWW------------------------------ A_aegypti_AAEL007642-PA EWGTSGRKGERPTLGHLYTLVDKGGMIRAVRHIEKLLKVPESAQPDSGPAAPIDVDLELNRLIEKQLEGIAYPSSTALQNGDISITQVNN------------------------------ T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ----------------------ASYVITD----------------------------------LTQLRKIKSMERAQ--GVSITRELLWW------------------------------ M_musculus_ENSMUSP00000055073 ----------------------ASYVITD----------------------------------LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ----------------------AERLSSS----------------------------------WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ G_aculeatus_ENSGACP00000025500 ----------------------AVRVVPS----------------------------------SLEVRMLERVEAA---GRSPTSELLWS------------------------------ T_guttata_ENSTGUP00000011997 --PECC----------------AVYRIQ---D-----------------------REKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF O_anatinus_ENSOANP00000021129 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF G_gallus_ENSGALP00000020950 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF B_taurus_ENSBTAP00000029006 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF E_caballus_ENSECAP00000003689 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF X_tropicalis_ENSXETP00000003054 ---------------------------------------------------------------------------------------MWS------------------------------ H_sapiens_ENSP00000288602 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF P_troglodytes_ENSPTRP00000033866 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF C_familiaris_ENSCAFP00000005841 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF P_pygmaeus_ENSPPYP00000020265 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF M_musculus_ENSMUSP00000002487 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF R_norvegicus_ENSRNOP00000014604 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF A_carolinensis_ENSACAP00000011088 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF T_nigroviridis_ENSTNIP00000000196 --QECC----------------AVFRLL---E-----------------------GRKRLTDWDTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF T_rubripes_ENSTRUP00000004441 --QDCC----------------AVFRLL---E-----------------------GRKRLTDWDTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF D_melanogaster_FBpp0079568 ENELCQ----------------KEYAIAKRHPVIGM-VGVEDCQKLPQHKDCLSLGITIEVDKTENCYWED--------GSTY--RGVANV----------------------------- O_latipes_ENSORLP00000020929 --QDCC----------------AVFRLL---E-----------------------GRKRLTDWNTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF O_cuniculus_ENSOCUP00000012185 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF G_aculeatus_ENSGACP00000000078 --PQCC----------------AVFRLH---P-----------------------GQRRSPPMCVESEATS--------DHSCKEEPLCNT--STLSFILKPADVLAFLSPCLYINLSDD A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 --PECC----------------AVFRLLQEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF H_sapiens_ENSP00000251849 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF M_mulatta_ENSMMUP00000009777 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF P_pygmaeus_ENSPPYP00000014975 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF E_caballus_ENSECAP00000010011 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF M_musculus_ENSMUSP00000108571 --PECC----------------AVFRLLQEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF C_familiaris_ENSCAFP00000007376 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF O_latipes_ENSORLP00000012350 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF B_taurus_ENSBTAP00000005930 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF M_domestica_ENSMODP00000007826 --PECC----------------AVFRLLHEHK-----------------------GKKTRLDWNTDAASLV--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF G_gallus_ENSGALP00000007991 --PECC----------------AVFRLVTEPK-----------------------GKKVRLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF D_rerio_ENSDARP00000048390 --PECC----------------AVYRVQ---D-----------------------GEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF M_domestica_ENSMODP00000011339 ----------------------AERISSS----------------------------------WLEVRHIEKYMEQ---GKSGTRELLWS------------------------------ G_aculeatus_ENSGACP00000004834 --QDCC----------------AVFRLL---E-----------------------GRKRLTDWETDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF A_carolinensis_ENSACAP00000013056 --PECC----------------AVFRLLNEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAYCDICQKFLLNGF T_nigroviridis_ENSTNIP00000010036 --PECC----------------AVYRIQ---D-----------------------GEKKPIGWDTDISWLT--------LEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF T_rubripes_ENSTRUP00000029372 --PECC----------------AVYRMQ---D-----------------------GEKKPIGWDTDISWLT--------LEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF T_rubripes_ENSTRUP00000016249 --PQCC----------------AVFRLHPGQS-----------------------SKKLRMDWNTDSTSLI--------GQELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF G_aculeatus_ENSGACP00000025456 --PECC----------------AVYRIQ---D-----------------------EEKKPIGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF T_nigroviridis_ENSTNIP00000015593 --PQCC----------------AVFRLHPGQS-----------------------SKKLRMDWNTDSTSLI--------GQELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF T_rubripes_ENSTRUP00000004702 VGKIMV----------------GLYPYEALHA--------------------------------DDLGFKK--------GERM--KILEE------------------------------ A_gambiae_AGAP011710-PA RDDHWSKFGDCCQQCSQFISGPAMFAGDHKFHPECFRCESCKVFIGDRESYALLERSKLYWYVLTGAKNAIAPPKDRIISNRIRVRYLIP------------------------------ O_latipes_ENSORLP00000014365 --PQCC----------------AVFRLHPGQT-----------------------NKKLRMDWNTDSTSLI--------GEELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF D_rerio_ENSDARP00000008826 --DVVI----------------AQYDFQPASE--------------------------------NDLQFKK--------GDRL--RIIKE------------------------------ E_caballus_ENSECAP00000003552 --PECC----------------AVFRLLHEHK-----------------------GKKARLDWNTDAASLI--------GEELQVDFLDHVPLTTHSFARKTFLKLASCDICQKFLLNGF D_rerio_ENSDARP00000071167 --QDCC----------------AVFRLL---E-----------------------GRKRLTEWDTDITPLV--------GEELLVEVLDDVPLTMHNFVRKTFFKLAYCDFCHKFLFNGF C_familiaris_ENSCAFP00000011788 --RFVV----------------ALYDYSSVND--------------------------------RDLQMLK--------GEKL--QILKE------------------------------ O_latipes_ENSORLP00000015921 SYKIVI----------------GLYPYEAVHS--------------------------------DDLGFKK--------GEKM--KVLEE------------------------------ O_anatinus_ENSOANP00000008740 QGVIVV----------------ALYPYDGIHQ--------------------------------DDLSFKK--------GEKL--KVLEE------------------------------ O_latipes_ENSORLP00000021561 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 --EMVI----------------AIYPYEGLHP--------------------------------DDLSFKK--------GEKM--KVLEE------------------------------ A_gambiae_AGAP006219-PA ENELCQ----------------KEYAIAKRHPTIGQKLPLEECDDLPLQKSCMRLGIDLDIKPNDDCYWEN--------GASY--RGIMDR----------------------------- G_aculeatus_ENSGACP00000018983 VGKIVI----------------SLYPYEALHD--------------------------------DDLGFKK--------GEKM--KILEE------------------------------ C_familiaris_ENSCAFP00000015667 --NLVI----------------ALHSYEPSHD--------------------------------GDLGFEK--------GEQL--RILER------------------------------ B_taurus_ENSBTAP00000037887 --NLVI----------------ALHSYEPSHD--------------------------------GDLGFEK--------GEQL--RILEQ------------------------------ M_musculus_ENSMUSP00000100967 ----------------------------------------------------------------GELAFRK--------GDMV--TILEACEDKS------------------------- R_norvegicus_ENSRNOP00000027730 ----------------------------------------------------------------GELAFRK--------GDMV--TILEACEDKS------------------------- C_elegans_F33E2.2a ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA KDDYWAKYGECCQQCGQVISGPVMVAGDHKFHPECFCCESCKIYIGDREAYALLERSKLFCGQCYKKRMNDTTKVDRQIPGSAMTHDIDG------------------------------ X_tropicalis_ENSXETP00000010512 --PECC----------------AVYRVQ---D-----------------------GEKKPIGWDTDISWIT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF P_pygmaeus_ENSPPYP00000020565 --HLVV----------------ALYDYAAMND--------------------------------RDLQMLK--------GEKL--QVLKG------------------------------ D_rerio_ENSDARP00000095291 --PECC----------------AVFKLQREHS-----------------------AKKLRMDWSTDSTSLV--------GEELLVEVLDHVPLTTHNFVRKTFLKLAFCDICQKFLLHGF T_rubripes_ENSTRUP00000007128 GVTFFV----------------ALYDYEARTS--------------------------------DDLSFTK--------GDRF--QIINN------------------------------ O_latipes_ENSORLP00000020461 ----------------------------------------------------------------------------------FDNSVLQL------------------------------ O_latipes_ENSORLP00000021875 --NIAL----------------AVYSYEPKHD--------------------------------GDLGFEK--------GDKL--KILNK------------------------------ C_intestinalis_ENSCINP00000011940 EQEIYI----------------ALYDYGARAK--------------------------------NHLTIKK--------GDRM--IMLYK------------------------------ H_sapiens_ENSP00000259089 --HFVV----------------ALYDYTAMND--------------------------------RDLQMLK--------GEKL--QVLKG------------------------------ A_aegypti_AAEL004592-PA --RIVV----------------ALYNYNAREE--------------------------------TDVSFVK--------GDRM--EVLDD------------------------------ T_rubripes_ENSTRUP00000008303 RVTLFV----------------ALYDYEARTE--------------------------------DDLSFRK--------GEKF--QIINS------------------------------ X_tropicalis_ENSXETP00000003560 --------------------------------------------------------------------------------------MIKC------------------------------ X_tropicalis_ENSXETP00000046976 --------------------------------------------------------------------------SGAILGRSETKECVYY------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 --------------------------------------------------------MDPAMKLAFGVFVISCSSAGAILGHSDAQRCVHS------------------------------ P_pygmaeus_ENSPPYP00000001840 --NLVI----------------ALHSYEPSHD--------------------------------GDLGFEK--------GEQL--RILEE------------------------------ E_caballus_ENSECAP00000020913 --NLVI----------------ALHRYEPSHD--------------------------------GDLGFEK--------GEQL--RILEQ------------------------------ T_rubripes_ENSTRUP00000030627 ----------------------------------------------------------------SPLNTALSVDSTRSEGQHFENSVLQL------------------------------ T_nigroviridis_ENSTNIP00000020756 VEKIVI----------------ALYPYEALHP--------------------------------DDLGFKK--------GERM--KILEE------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- P_troglodytes_ENSPTRP00000008285 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- M_mulatta_ENSMMUP00000000286 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- E_caballus_ENSECAP00000012782 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLVQNEFFAP-------ASLL----- C_familiaris_ENSCAFP00000014260 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- P_pygmaeus_ENSPPYP00000005053 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- B_taurus_ENSBTAP00000028115 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DILVQNEFFAP-------ASLL----- R_norvegicus_ENSRNOP00000007932 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQIELFAP-------ATLL----- M_musculus_ENSMUSP00000074471 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLVQIELFAP-------ATLL----- M_domestica_ENSMODP00000023115 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIRNDFLAP-------ARLL----- G_gallus_ENSGALP00000015600 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIRNQFLAP-------ASLL----- T_guttata_ENSTGUP00000006104 -----------------------W-GTTNCTVADLV---------------------------------------------------------DLLIRNQFLAP-------ASLL----- A_carolinensis_ENSACAP00000002933 -----------------------W-GTLNCTVSDLV---------------------------------------------------------DLLVKNQFLAP-------ARLL----- T_nigroviridis_ENSTNIP00000019071 -----------------------W-GTTNCTVGELV---------------------------------------------------------DMLKNNSLLAA-------VTLL----- O_latipes_ENSORLP00000003907 -----------------------W-GTTNSTVGELV---------------------------------------------------------DILRSLNLLAA-------ANLL----- G_aculeatus_ENSGACP00000005326 -----------------------W-GTTNSTVGELV---------------------------------------------------------CILKSCKLLAA-------ASLL----- T_rubripes_ENSTRUP00000042842 -----------------------W-GTSNCTVGELV---------------------------------------------------------DILKSHKLLAA-------AAIV----- O_cuniculus_ENSOCUP00000003553 -----------------------W-GTTNCTVGDLV---------------------------------------------------------DLLIQNEFFAP-------ASLL----- O_anatinus_ENSOANP00000003026 -----------------------W-GTSNCTVGDLV---------------------------------------------------------DLLIRNQFLAP-------ASLL----- C_intestinalis_ENSCINP00000015329 -----------------------W-STSNATVQDLI---------------------------------------------------------NVLTSLGLISM-------VNMLKSQVT X_tropicalis_ENSXETP00000014885 -----------------------W-GTTNCTVQDLK---------------------------------------------------------DLLQKNGFSAA-------ASLL----- D_rerio_ENSDARP00000023777 -----------------------W-GTSDCTVGDLV---------------------------------------------------------EILIRHQLFAA-------VTVL----- T_guttata_ENSTGUP00000010778 -----------------------W-GVRLATVQQLL---------------------------------------------------------DLLQGLQLYRA-------AQVI----- H_sapiens_ENSP00000358997 -----------------------W-INRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- P_pygmaeus_ENSPPYP00000023353 -----------------------W-INRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- B_taurus_ENSBTAP00000021407 -----------------------W-INRNARVADLV---------------------------------------------------------RILTHLQLLRA-------RDII----- C_elegans_K09B11.1 -----------------------W-SSKGYSTTHLY---------------------------------------------------------QLFAKTKLIRL-------MRMM----- C_familiaris_ENSCAFP00000000535 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QILQEMGHHRA-------IHLI----- D_rerio_ENSDARP00000092301 -----------------------W-GCRNGTVGALL---------------------------------------------------------KILEGLQWFRA-------RDII----- G_gorilla_ENSGGOP00000000218 -----------------------X-XXXXXXXXXXX---------------------------------------------------------XXXXXXXXXXX-------XXXX----- E_caballus_ENSECAP00000007763 -----------------------W-INRNARVADLV---------------------------------------------------------RILTHLQLLRA-------RDII----- M_mulatta_ENSMMUP00000026705 -------------------------XNRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- O_anatinus_ENSOANP00000017468 -----------------------W-VNRNARVGDLI---------------------------------------------------------QILTDLQLLRA-------RDII----- X_tropicalis_ENSXETP00000031192 -----------------------W-SNRNAVVGELL---------------------------------------------------------SILRSLNLLRA-------LDVF----- R_norvegicus_ENSRNOP00000005686 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLHEMGHQRA-------IHLI----- M_musculus_ENSMUSP00000033769 -----------------------W-INRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- G_aculeatus_ENSGACP00000001480 -----------------------W-CNRNGSVGELL---------------------------------------------------------ELLERLEMLRP-------RDVI----- A_carolinensis_ENSACAP00000012253 -----------------------W-MNRNARVSDLL---------------------------------------------------------QILDDLQLYRA-------HNVI----- M_domestica_ENSMODP00000037830 -----------------------W-INRNARVADLL---------------------------------------------------------HILTSLQLRSG-------PGHR----- R_norvegicus_ENSRNOP00000053167 -----------------------W-INRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- M_musculus_ENSMUSP00000020448 -----------------------W-AQKNKTIGDLL---------------------------------------------------------EVLQDMGHQRA-------IHLI----- B_taurus_ENSBTAP00000033611 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QILQEMGHHRA-------IHLI----- A_gambiae_AGAP002966-PA -----------------------W-GNYNHTITELF---------------------------------------------------------VVLSREKLYNC-------MELI----- C_familiaris_ENSCAFP00000028744 -----------------------W-INRNARVADLV---------------------------------------------------------SILTHLQLLRA-------RDII----- P_troglodytes_ENSPTRP00000008814 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLQEMGHRRA-------IHLI----- H_sapiens_ENSP00000261233 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLQEMGHRRA-------IHLI----- M_mulatta_ENSMMUP00000021862 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLQEMGHRRA-------IHLI----- T_rubripes_ENSTRUP00000016336 -----------------------W-EIRNGRVGELV---------------------------------------------------------NLLEGLELLRP-------RDVI----- A_gambiae_AGAP003062-PA ---------------------------VDESVSDFI------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLQEMGHRRA-------IHLI----- O_anatinus_ENSOANP00000009429 -----------------------W-AQKNKTVGDLL---------------------------------------------------------QVLEDMGHQRA-------IDCL----- G_gallus_ENSGALP00000035437 -----------------------W-GVRLATVRQLL---------------------------------------------------------DLLQALQLYRA-------AQVI----- P_troglodytes_ENSPTRP00000038647 -----------------------W-INRNARVADLV---------------------------------------------------------HILTHLQLLRA-------RDII----- P_pygmaeus_ENSPPYP00000015274 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLCRLELYRA-------AQII----- E_caballus_ENSECAP00000010808 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLCHLELYRA-------AQIV----- T_nigroviridis_ENSTNIP00000007783 -----------------------W-GSRNGRVRDLL---------------------------------------------------------HLLEGLELLRP-------RDLI----- D_rerio_ENSDARP00000067130 -----------------------W-AQRNKTVEDLL---------------------------------------------------------KVLDEMGHARA-------RSLF----- P_troglodytes_ENSPTRP00000025212 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLCRLELYRA-------AQII----- H_sapiens_ENSP00000256458 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLCRLELYRA-------AQII----- D_melanogaster_FBpp0084549 -----------------------WGGQYNHTVQTLF---------------------------------------------------------ALFKKLKLHNA-------MRLI----- C_familiaris_ENSCAFP00000007680 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLRRLQLYRA-------AQII----- M_mulatta_ENSMMUP00000026192 -----------------------W-GMRQATVQQLV---------------------------------------------------------DLLCHLELYRA-------AQII----- M_domestica_ENSMODP00000033729 -----------------------W-GMRQATVQQLL---------------------------------------------------------DLLYRLELYRA-------AQVI----- A_aegypti_AAEL007642-PA -----------------------LDYNLPAKRDDVV------------------------------------------------NPPNTVPDSIIEGSLPLLSRSDNNDQSIGAVPMLSD T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 -----------------------W-GMRQATVQQLL---------------------------------------------------------DLLCHLELYRA-------AQII----- M_musculus_ENSMUSP00000055073 -----------------------W-SMRQATVQQLV---------------------------------------------------------DLLCHLELYRA-------AQIV----- A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QVLQEMGHRRA-------IHLI----- G_aculeatus_ENSGACP00000025500 -----------------------W-AQENPRLLDLV---------------------------------------------------------KLLQEMGHQRA-------LQLL----- T_guttata_ENSTGUP00000011997 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPPEEASLGETTPASGSYPSV--PPSDSVGPPILP--SPS------P-----SKSIPIP-------QPL------ O_anatinus_ENSOANP00000021129 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLGETTLTSGSSPSA--TPSDSIGPPIVA--SPS------P-----SKSIPIP-------QSF------ G_gallus_ENSGALP00000020950 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPISQEETTLGETTPASGSYPSV--PPSDSVGPPILP--SPS------P-----SKSIPIP-------QPF------ B_taurus_ENSBTAP00000029006 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETTLPCGSSPSA--PPSDSIGPPILT--SPS------P-----SKSIPIP-------QPF------ E_caballus_ENSECAP00000003689 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVSQEEASLAETALTSGSSPSA--PPSDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ X_tropicalis_ENSXETP00000003054 -----------------------W-GQKLPTLQKLV---------------------------------------------------------ERLQKLEMYRA-------LGIL----- H_sapiens_ENSP00000288602 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTSGSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ P_troglodytes_ENSPTRP00000033866 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTSGSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ C_familiaris_ENSCAFP00000005841 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASIAETALTSGSSPSA--PPSDSPGPPILT--SPS------P-----SKSIPIP-------QPF------ P_pygmaeus_ENSPPYP00000020265 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTSGSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ M_musculus_ENSMUSP00000002487 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVPQEEASFPETALPSGSS-SA--PPSDSTGPQILT--SPS------P-----SKSIPIP-------QPF------ R_norvegicus_ENSRNOP00000014604 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVPQEEAFSAETTLPSGCS-SA--PPSDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ A_carolinensis_ENSACAP00000011088 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHRPISQEETSLGESTTACGSYSSV--VPSDLSGSTVLP--SPS------P-----SKSIPIP-------QPF------ T_nigroviridis_ENSTNIP00000000196 RCQTCGYKFHQHCSSKVPTVCLDMDTVS-----K----R--FFPISSS------------H-IQSY--FKHSPSQSN--L--TPE------P-AGMD-LSPAPA-------FHF------ T_rubripes_ENSTRUP00000004441 RCQTCGYKFHQHCSSKVPTVCLDMGTAK-----RILICHYDSSVGVDE------------YPQILL--SENSPSQSN--L--TPE------P-AGRMDLSPTPA-------FHF------ D_melanogaster_FBpp0079568 --------------SASGKPCLRWSWLM-----KEI------------------------SDFPEL--IGQNYCRNPGSV--ENS------P-WCFVDSSRERI-------IEL------ O_latipes_ENSORLP00000020929 RCQTCGYKFHQHCSSKVPTVCLDMDTVS-----K----RCDSNSCTED------------FPVIVL--PESSPSQRNLAL--TPE------P-SGMDLLSPPST-------FHF------ O_cuniculus_ENSOCUP00000012185 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGAPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ G_aculeatus_ENSGACP00000000078 LTLTPFYGF---CMLRIVAYLVIIGGNP-----RMSVG---CVRRPGD------------SGASSL--RPLTSRRMRESL--TRF------P-REMHFICCGSP-------DNV------ A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTASD------------SGVPAP--PSFTMRRMRESV--SRM------PASSQHRYSTPHA-------FTF------ H_sapiens_ENSP00000251849 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ M_mulatta_ENSMMUP00000009777 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ P_pygmaeus_ENSPPYP00000014975 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ E_caballus_ENSECAP00000010011 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ M_musculus_ENSMUSP00000108571 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTVGD------------SGVPAP--PSFPMRRMRESV--SRM------PASSQHRYSTPHA-------FTF------ C_familiaris_ENSCAFP00000007376 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ O_latipes_ENSORLP00000012350 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFSHEEVSSEGTTPVSEVCPHL--PLTDSTGSICHP--TLS------P-----SKSIPIP-------PSY------ B_taurus_ENSBTAP00000005930 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTVGD------------GGVPAL--PSLTMRRMRESV--SRI------PPGSQHRYSTPHA-------FTF------ M_domestica_ENSMODP00000007826 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSNVGD------------SGVPAL--PPLTMRRMRESV--SQI------PISSQHRYSTPHA-------FTF------ G_gallus_ENSGALP00000007991 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSNISD------------SGVPAL--PPLTMRRMRESV--SRI------PVSSQHRYSTPHV-------FTF------ D_rerio_ENSDARP00000048390 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLASKFLVHHPITQEEVSSEGTTPISEMCPSL--PPSESTGSLCHP--TVS------P-----SKSIPIP-------QSF------ M_domestica_ENSMODP00000011339 -----------------------W-AQKNKTIGDLL---------------------------------------------------------QILQEMGHERA-------INLI----- G_aculeatus_ENSGACP00000004834 RCQTCGYKFHQHCSSKVPTVCVDMDTVT-----K----RNDTNPCTDE------------YPRILL--PENSPSQSNLAL--TPE------P-AGTDLLSPTSA-------FHF------ A_carolinensis_ENSACAP00000013056 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PHSNVGE------------SGMPAL--PPLTTRRMRESV--SRI------PVNSQHRYSTPHA-------FTF------ T_nigroviridis_ENSTNIP00000010036 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVSEVCPSL--PPSDSIGSICHS--TVS------P-----SKSIPIP-------PSF------ T_rubripes_ENSTRUP00000029372 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVSEVCPSL--PPSDSTGSICQS--TVS------P-----SKSIPIP-------PSF------ D_rerio_ENSDARP00000044241 ---------------------------------------------------------------------------------------------SSVHRYSNPHV-------SNY------ P_troglodytes_ENSPTRP00000025252 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ T_rubripes_ENSTRUP00000016249 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF-----PSPGD------------GGGPSL--PPLTSRRMRESL--TRF------P-SSAHRYSTPHA-------FNY------ G_aculeatus_ENSGACP00000025456 RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVSDACPSL--PPSDSTGSMCHT--TLS------P-----SKSIPIP-------PSF------ T_nigroviridis_ENSTNIP00000015593 RCQTCCYKFHEHCSTKVPTMCVDWSNIR-----QLLLF-----PSPGD------------SGAPSL--PSLTSRRMRDSL--TRF------P-SSAHRYSTPHA-------FNY------ T_rubripes_ENSTRUP00000004702 ---------------HGE-----WWKAK-----SLT------------------------TNREGF--IPSNYVGQADTM--ETE------D-WFFKDISRKDA-------ERQ------ A_gambiae_AGAP011710-PA --------------HSIRLVEIPWSGNRSDRIRLAT------------------------DDKPSGVKGVANGCKSCTCINQLFANICFPHRVTLNSDLMALRVGDKVLEVNGTPVRDVP O_latipes_ENSORLP00000014365 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLC-----PTPGE------------SGGPSF--PPPTSRRVRDSL--TRF------P-SSAHRFSTSHA-------FND------ D_rerio_ENSDARP00000008826 ---------------NGE-----WWLAK-----SLV------------------------TGYEGF--IPSTYVARAQTL--QVE------R-WFFKDMNRRDT-------ERL------ E_caballus_ENSECAP00000003552 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTFGD------------SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTLHA-------FTL------ D_rerio_ENSDARP00000071167 RCQTCGYKFHQHCSSKVPTVCVDMDTMT-----K----RCVNN--TED------------CPAILIYPATNSISQSDLPL--TSD------S-PGGELPSSPSN-------FCL------ C_familiaris_ENSCAFP00000011788 ---------------AGD-----WWWAR-----SLI------------------------TGREGY--VPSNFVTRVETL--EVE------K-WFFRSISRKDA-------ERQ------ O_latipes_ENSORLP00000015921 ---------------RGE-----WWKAR-----SLT------------------------TNKEGF--IPCNYVAQANTM--ETE------E-WFFKDLTRKDA-------ERQ------ O_anatinus_ENSOANP00000008740 ---------------HGE-----WWKAK-----SLS------------------------TKREGF--IPSNYVAKVNTL--ETE------E-WFFKDITRKDA-------ERQ------ O_latipes_ENSORLP00000021561 -----------------------M------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 ---------------YGE-----WWKAK-----SLS------------------------TKKEGY--IPSNYVAKLNSL--ETE------D-WFFKDITRKDA-------ERQ------ A_gambiae_AGAP006219-PA --------------TKSSKICMRWSKLM-----HTM------------------------SEFPHL--AGHNYCRNPPHAGPMDA------P-WCYVD--MQKT-------IEY------ G_aculeatus_ENSGACP00000018983 ---------------HGE-----WSKAK-----SLT------------------------TNKEGF--IPGNYVAQADSM--ETE------E-WFFKDITRKDA-------ERQ------ C_familiaris_ENSCAFP00000015667 ---------------NGE-----WWKAQ-----SLT------------------------TGQEGF--IPFNFVAKANSL--EPE------P-WFFKNLSRKDA-------ERQ------ B_taurus_ENSBTAP00000037887 ---------------NGE-----WWKAQ-----SLT------------------------TGQEGF--IPFNFVAKANSL--EPE------P-WFFKTLSRKDA-------ERQ------ M_musculus_ENSMUSP00000100967 -----------------------WYRAKHHG-----------------------------SGQEGL--LAAAALRQREAL--STDPKLSLMP-WFHGKISGQEA-------IQQ------ R_norvegicus_ENSRNOP00000027730 -----------------------WYRAKHHS-----------------------------SGQEGL--LAAAALRQREAL--STDPKLSLMP-WFHGKISGQEA-------IQQ------ C_elegans_F33E2.2a -----------------------MTSTTMVTTLDLV---------------------------------------------------------TPTSEEQPGPAPESSDFSTVVLSPDGS C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA --------SSKKIPHSIRLVEIPWSNVKKDGIRLST-----------------------DEHLYGIPSHSAVGCKGVRIS-----------EIDLTSDLMSLHIGDKILEVNGTPVRDAP X_tropicalis_ENSXETP00000010512 RCQTCGYKFHQRCSTEVPLMCVNYDRLD-----LLFVSKFFEHHPISQEEAPFEEVAPAAESSTPP--PPPDATGPLCLP--STS------P-----SKSIPIP-------QPF------ P_pygmaeus_ENSPPYP00000020565 ---------------TGD-----WWLAK-----SLV------------------------TGREGY--VPSNFVARVESL--EVE------R-WFFRSLGRKEA-------ERQ------ D_rerio_ENSDARP00000095291 RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLW----LFPTPGE------------NGALTL--PPLSSRRMQN----SRL------SFSPYHRYSTPNA-------LNY------ T_rubripes_ENSTRUP00000007128 --------------TEGD-----WWEAR-----SIT------------------------TGRTGY--IPSNYVAPADSI--QAE------E-WYFGKMGRKDA-------ERL------ O_latipes_ENSORLP00000020461 ---------------------------------------------------------------------------------------------QEQDHEEVVSP---------------- O_latipes_ENSORLP00000021875 --------------DDPE-----WYLAE-----SLT------------------------TGQQGY--IPFNFIA-MTTM--ETE------P-WFFRDISRNDA-------MRL------ C_intestinalis_ENSCINP00000011940 ---------------DGA-----WSVVRLLQPNRMN------------------------SNTKGY--VPSNFIRRESLI--NSQ------PPWMFDTAVRSEA-------ITL------ H_sapiens_ENSP00000259089 ---------------TGD-----WWLAR-----SLV------------------------TGREGY--VPSNFVARVESL--EME------R-WFFRSQGRKEA-------ERQ------ A_aegypti_AAEL004592-PA --------------TESD-----WWRVV-----HLK------------------------TRQEGL--IPWNFVAEDRSV--NSE------D-WFFENVSRKEA-------DKL------ T_rubripes_ENSTRUP00000008303 --------------SEGD-----WWEAR-----SLT------------------------TGGNGY--IPSNYVAPVDSI--QAE------D-WYFGKLGRKDA-------ERQ------ X_tropicalis_ENSXETP00000003560 -----------------------WS----------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000046976 --------------------NANWEKDKTNPNGTEICYG------------------------------------------------------DNDKRRHCFATWKNISGSIEIVKQGCW T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ---------------SFSPASSSWLEGQGNISGVVTCSG------------------------------------------------------EKNKKLHCFATWKNLSGVVQVVQQGCW P_pygmaeus_ENSPPYP00000001840 ---------------SGE-----WWKAQ-----SLT------------------------TGQEGF--IPFNFVAKANSL--EPE------P-WFFKNLSRKDA-------ERQ------ E_caballus_ENSECAP00000020913 ---------------SGE-----WWKAQ-----SLT------------------------TGQEGF--IPFNFVAKANSL--EPE------P-GPRDDGPSLSA-------LRSW----- T_rubripes_ENSTRUP00000030627 ---------------------------------------------------------------------------------------------QEQDQDEAVSP---------------- T_nigroviridis_ENSTNIP00000020756 ---------------RGE-----WWRAK-----SLS------------------------TNREGF--IPSNYVGQADTM--ETE------D-WFFKDISRKDA-------ERQ------ 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 LPDAV---PKTAN-----------------TLPSK-E---AITVQ--------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008285 LPDAV---PKTAN-----------------TLPSK-E---AVTVQ--------------------------------------------------------------------------- M_mulatta_ENSMMUP00000000286 LPDAV---PKT-N-----------------TLPSK-E---AVTVQ--------------------------------------------------------------------------- E_caballus_ENSECAP00000012782 LPDAV---PKTVN-----------------ILPSK-E---AITIQ--------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014260 LPDAI---PKTPN-----------------TVPSE-E---AVTVQ--------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005053 LPDAV---PKTAN-----------------TLPSK-E---AVTVQ--------------------------------------------------------------------------- B_taurus_ENSBTAP00000028115 LPDAV---PKNVN-----------------TLPSKVT---VVAVQ--------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000007932 LPDAV---PQAVH-----------------SLPPR-E---AATVA--------------------------------------------------------------------------- M_musculus_ENSMUSP00000074471 LPDAV---PQTVK-----------------SLPPR-E---AATVA--------------------------------------------------------------------------- M_domestica_ENSMODP00000023115 LPDII---PEIVQ-----------------VLP-Q-E---KLATQ--------------------------------------------------------------------------- G_gallus_ENSGALP00000015600 LPEAV---GMAQE--------------VTLPLSSQ-E---TLPVC--------------------------------------------------------------------------- T_guttata_ENSTGUP00000006104 LPEAV---RMPQE--------------VTLPLSSQ-E---TLPIH--------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002933 LPGNV---DLAGV---------------VYPVQFS-E---SVP----------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019071 LPGLK---DAIPA----------------------------ETLQPGP------------------------PSGET------------------------------------------- O_latipes_ENSORLP00000003907 LPVFV---LHMNN----------------KEVLSK-E---TQQVS----------------------------SVKA------------------------------------------- G_aculeatus_ENSGACP00000005326 LPGRP---LLSTNISLSFCPHA------EQGAVSQ-E---TQETQRAS------------------------PAVDT------------------------------------------- T_rubripes_ENSTRUP00000042842 LPGMI---QITTA------------------------------MQIAF------------------------NCTET------------------------------------------- O_cuniculus_ENSOCUP00000003553 LPXXX---XXXXX-----------------XXXXX-X---XXXXX--------------------------------------------------------------------------- O_anatinus_ENSOANP00000003026 LPDAV---PKTDQ---------------TFPLPSQ-E---TLPIQ--------------------------------------------------------------------------- C_intestinalis_ENSCINP00000015329 MPPPYEEAVNREQTQSTLPYPQQAQYRPVPTPVGQPYQPYPNHNIHQPVYNYESHRSSHPPIPPRPSIFSDFASIRQPTRPN-------------------------------------- X_tropicalis_ENSXETP00000014885 LPAKN---TENVN----------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000023777 LPDHS---VCHTH------T---------GSVWCE-E---AAPAS----------------------------AVCL------------------------------------------- T_guttata_ENSTGUP00000010778 LDWTS---ASSVTSPEK--EE--------SEPP--KQ----IISVPPTEGKV----RDKENAISLLPFPDSSHLGAV------------------------------------------- H_sapiens_ENSP00000358997 TAWHP---PAPLPSPGTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAST----------FLSP--------------------------------------------- P_pygmaeus_ENSPPYP00000023353 TAWHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAST----------LLSP--------------------------------------------- B_taurus_ENSBTAP00000021407 TAWHP---PAPLLPPSTTSLT-------PSSIS--AP---SEAAVPGHRKLP----SLAST----------FLSP--------------------------------------------- C_elegans_K09B11.1 RSQVHEKYHYLENKVTNSTSRVSKQMVQPPGS---------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000000535 VNYGA-----------------------------------------------------------------------A------------------------------------------- D_rerio_ENSDARP00000092301 LKAQL-YFPRSYLVYLFTACD-------PSIIY--LY---SRQFPQNHKEQQ----PSTVT----------FIKEHL------------------------------------------- G_gorilla_ENSGGOP00000000218 XXXHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SLAST----------LLSP--------------------------------------------- E_caballus_ENSECAP00000007763 TAWHP---PAPNKPPSTTALK-------PSSLS--AP---SEAEALSPRKLQ----SSAST----------LLSP--------------------------------------------- M_mulatta_ENSMMUP00000026705 TAWHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAST----------LLSP--------------------------------------------- O_anatinus_ENSOANP00000017468 TSCEL---PQPSARPNTNVPS-------RGRTW--AK---EGGWAFSPSPLP----ES-TS----------WPPW--------------------------------------------- X_tropicalis_ENSXETP00000031192 ESWRSRYVPESTQNFSQANPL-------PPPYP--YPGPESAPYFQKPQTKT----DSLQT----------QATN--------------------------------------------- R_norvegicus_ENSRNOP00000005686 MNYGV-----------------------------------------------------------------------N------------------------------------------- M_musculus_ENSMUSP00000033769 TAWHP---PAPVVPPSTAAPR-------PSSIS--AG---SEAGDWSPRKLQ----SSAST----------FLSP--------------------------------------------- G_aculeatus_ENSGACP00000001480 LRSVP---PLPSHKQSEATPT-------LSTVRVGYT---DGDDIISPKFQSSGLSFEPYS----------------------------------------------------------- A_carolinensis_ENSACAP00000012253 ASCES---ACSVSSTSTSPPL-------SLCLSLF-----FSKRDKDPERKW----SPSQT----------QESP--------------------------------------------- M_domestica_ENSMODP00000037830 DPEPP---SLPPAAPSTCTPTPPWPPPQPKPQS--GP---KE-EGARPREAC----QSFST----------FPSP--------------------------------------------- R_norvegicus_ENSRNOP00000053167 TAWHP---PASVLPPSTGAPR-------PSSIS--AG---SETEDWSPRKLQ----SSAST----------FLSP--------------------------------------------- M_musculus_ENSMUSP00000020448 INYGV-----------------------------------------------------------------------S------------------------------------------- B_taurus_ENSBTAP00000033611 ANYGA-----------------------------------------------------------------------T------------------------------------------- A_gambiae_AGAP002966-PA KRYVD---SRYHVLIKESASDGRNAVANMATFSGANN----------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000028744 TAWHP---PAPLLPPSTSAPR-------PSSPP--AP---CEADVPRPRKLP---TASAST----------LPSP--------------------------------------------- P_troglodytes_ENSPTRP00000008814 TNYGA-----------------------------------------------------------------------V------------------------------------------- H_sapiens_ENSP00000261233 TNYGA-----------------------------------------------------------------------V------------------------------------------- M_mulatta_ENSMMUP00000021862 TNHGA-----------------------------------------------------------------------V------------------------------------------- T_rubripes_ENSTRUP00000016336 LLKPP---PPPAPAAPPTAPA-------APRVP--SP---PFNTV----------WSKRSS----------PRPA--------------------------------------------- A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 TNYGA-----------------------------------------------------------------------V------------------------------------------- O_anatinus_ENSOANP00000009429 TNPGE-----------------------------------------------------------------------S------------------------------------------- G_gallus_ENSGALP00000035437 LDWIS---PSSISTSEK--EE-------LVEPP--KQ---ENVSLTPTENKH----KEKENEISLLPSSDLSQPGIS------------------------------------------- P_troglodytes_ENSPTRP00000038647 TAWHP---PALLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAST----------LLSP--------------------------------------------- P_pygmaeus_ENSPPYP00000015274 LNWKP---APEIRCPIPAFPD-------SVKPE--KP---LAASVKKAENEQ----EEGQP----------VRMATS------------------------------------------- E_caballus_ENSECAP00000010808 LNWKP---APEIKSSVPYFPD-------AVNPG--RP---LAASVRDTKDGQ----EQGQP----------TRTAAS------------------------------------------- T_nigroviridis_ENSTNIP00000007783 LNGQS---SPPLRTPVTSSLR---------------PDSSPFEGVSCPDWERRWFWSRPSM----------LAHP--------------------------------------------- D_rerio_ENSDARP00000067130 QSQDS------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000025212 LNWKP---APEIRCPVPAFPD-------SVKPE--KP---LAASVRKAEDEQ----EEGQP----------VRMATF------------------------------------------- H_sapiens_ENSP00000256458 LNWKP---APEIRCPIPAFPD-------SVKPE--KP---LAASVRKAEDEQ----EEGQP----------VRMATF------------------------------------------- D_melanogaster_FBpp0084549 KDYVSEDLHKYIPRSVPTISE--------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000007680 LNWKP---VPEINCSFLDFPE-------AVKPG--RP---LEASVRTMEDEQ----EKGPS----------VRPADF------------------------------------------- M_mulatta_ENSMMUP00000026192 LNWKP---VPEIRCPIPAFPD-------CVKPE--RP---LAASVRKTEDEQ----EEGQP----------VRMATF------------------------------------------- M_domestica_ENSMODP00000033729 LDWGA---IPEIASASHVLPD-------STHPG--KS---SLASLRKPEETQ----EKGLQ----------KSSGLT------------------------------------------- A_aegypti_AAEL007642-PA LLNADGQDTEASTSDNDSTPRQTIEGNTLSSTSDSTSESSSNSTPTESLSRILPMVLPTIPEAGEVPN---------------------------------------------------- T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 LNWKP---VLEVKSSIPDFSD-------TVKPG--KP---LAASVRNTEDKQ----ETGQP----------VRPPTF------------------------------------------- M_musculus_ENSMUSP00000055073 LSWKP---VPESTSPLPAFPE-------AVKPG---A---VATSRRNLKDEQ----EKVRP----------VKPRSL------------------------------------------- A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 TNYGA-----------------------------------------------------------------------V------------------------------------------- G_aculeatus_ENSGACP00000025500 QGPGS------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011997 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQSL-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR O_anatinus_ENSOANP00000021129 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGL-RGDGE--------------------------------------L G_gallus_ENSGALP00000020950 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGV-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR B_taurus_ENSBTAP00000029006 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGF-RSDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR E_caballus_ENSECAP00000003689 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGF-RSDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR X_tropicalis_ENSXETP00000003054 QQWSP---LSVIASKV---PE-------RRKAE--KE---SDLKTDNKLPEL----TYTSP----------LELPTP------------------------------------------- H_sapiens_ENSP00000288602 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGF-RGDG---------------------------------------- P_troglodytes_ENSPTRP00000033866 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGF-RGDG---------------------------------------- C_familiaris_ENSCAFP00000005841 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNIDKFE---------LFPQVELEKQKDLIRDQGF-RSDGAPLNHLMRCLRKCQSRTPSPLLHSVPSEIVFDFEPGPVFR P_pygmaeus_ENSPPYP00000020265 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGF-RGDG---------------------------------------- M_musculus_ENSMUSP00000002487 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID--E---------KFPEVELQDQRDLIRDQGF-RGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR R_norvegicus_ENSRNOP00000014604 RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID--E---------KFPEVELQDQRDLIRDQGF-RGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR A_carolinensis_ENSACAP00000011088 RQGDEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGL-RGEG---------------------------------------- T_nigroviridis_ENSTNIP00000000196 --PVPGGDGQSLQRHRSTSTP---------NVHMVSTVGVAGASFIE--------------------EVRKSNNVI---GPE-------------------------------------- T_rubripes_ENSTRUP00000004441 --PMPGGDGQSLQRHRSTSTP---------NVHMVSTVGPAGASIIE--------------------L-----NVSFCCSYC-------------------------------------- D_melanogaster_FBpp0079568 CDIPKCADKIWI-AIVGTTAAIILIFIIIFAIILFKRRTIMHYGM----------------------RNIHNINTPS------------------------------------------- O_latipes_ENSORLP00000020929 --PVSGGEGQSLQRHRSTSTP---------NVHMVSTVDLASVSIIE--------------------EALKFNTIV---GPE-------------------------------------- O_cuniculus_ENSOCUP00000012185 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- G_aculeatus_ENSGACP00000000078 SEPLAVGGGKQPIRLRKHREP---------NTSTVSSTLLLHASHLQ--------------------DAMRDHDSG-------------------------------------------- A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- H_sapiens_ENSP00000251849 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- M_mulatta_ENSMMUP00000009777 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- P_pygmaeus_ENSPPYP00000014975 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- E_caballus_ENSECAP00000010011 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHT---------------------------------------------- M_musculus_ENSMUSP00000108571 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLHVDSRMIE--------------------DAIRSHSES-------------------------------------------- C_familiaris_ENSCAFP00000007376 NSSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- O_latipes_ENSORLP00000012350 RPNEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGLQRSDGVTTEQMSECQRTSADKSPAFMSLTHLIHLLLHHHPP---S B_taurus_ENSBTAP00000005930 SASSPSSEGSLSQRQRSTSTP---------NVHMVSATLPVDSRMIENNSLNASPRAWSRRFCVRGRDAIRSHSES-------------------------------------------- M_domestica_ENSMODP00000007826 STSPPSSEGSLSQRQRSTSTP---------NVHMVSTTMPVDSRIIE--------------------DAIRSHSES-------------------------------------------- G_gallus_ENSGALP00000007991 NTSNPSSEGTLSQRQRSTSTP---------NVHMVSTTMPVDSRIIE--------------------DAIRNHSES-------------------------------------------- D_rerio_ENSDARP00000048390 RPGEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGLPRSDGAPSQHPARCLRKNRTRTSSPLLSSHPNDIVFDFEPEPVFR M_domestica_ENSMODP00000011339 VNHGR-----------------------------------------------------------------------T------------------------------------------- G_aculeatus_ENSGACP00000004834 --PMPSGEGQSLQRHRSTSTP---------NVHMVSTVGPAGTSIIE--------------------EALKSNNILVLAGPE-------------------------------------- A_carolinensis_ENSACAP00000013056 SPSNPSPECSLSQRQRSTSTP---------NVHMVSTTMPVDNRIIE--------------------DAIRSHSES-------------------------------------------- T_nigroviridis_ENSTNIP00000010036 RSSEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGLPRSDGAPLTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPIFR T_rubripes_ENSTRUP00000029372 RSSEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRVQGLPRSDGAPPTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPVFQ D_rerio_ENSDARP00000044241 TSPYPPSGAALTQRLRSTSTP---------NVTMLSTTVPVDSSLIE---LDTSPSSWCQQFSLKRRDAIRVHSSA-------------------------------------------- P_troglodytes_ENSPTRP00000025252 NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE--------------------DAIRSHSES-------------------------------------------- T_rubripes_ENSTRUP00000016249 NTSYPPAGGGLSQRQRSTSTP---------NVHMVSTTLPVDSSMIE--------------------DVMRDHDSA-------------------------------------------- G_aculeatus_ENSGACP00000025456 RPNDEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGLPRSDGAPPTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPVFR T_nigroviridis_ENSTNIP00000015593 NTSYAPTGGGLSQRQRSTSTP---------NVHMVSTTLPVDSSMIE--------------------DVMRDHDSA-------------------------------------------- T_rubripes_ENSTRUP00000004702 LLAPANRPGSYLIRESETSK----------GSFSLSIRVVDDSGA----------------------DSVKHYKIRL------------------------------------------- A_gambiae_AGAP011710-PA LESLQNLIEASAGKALQLTVEHDPDVVALATAGGLPGCKGILSASYAGTETNCTDVLNNNQNEGE------------------------------------------------------- O_latipes_ENSORLP00000014365 TEPYTPPGGGLSQRQRSTSTP---------NVHMGSTTLPVDSSMIE--------------------DAMRDHDSA-------------------------------------------- D_rerio_ENSDARP00000008826 LLAPGNKPGSFLVRESETTK----------GAFSLSIRDSTPEQG----------------------DVVKHYKIRA------------------------------------------- E_caballus_ENSECAP00000003552 NISSSCSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRVIE--------------------DAIRSHSES-------------------------------------------- D_rerio_ENSDARP00000071167 --FIRGEDGQSLQRHRSTSTP---------NVHMVSTLEPGAAGLLE--------------------EPFKISTVASSTGYE-------------------------------------- C_familiaris_ENSCAFP00000011788 LLAPVNKAGSFLIRESETNK----------GAFSLTVKDVT-TQG----------------------EMIKHYKIRS------------------------------------------- O_latipes_ENSORLP00000015921 LMAPANKPGSYLIRESETSK----------GSYSLSIRDRDNQGM----------------------DLVKHYKIRK------------------------------------------- O_anatinus_ENSOANP00000008740 LLAPGNSAGAFLIRESETQK----------GSFSLSIRDFDPQQG----------------------DVIKHYKIRS------------------------------------------- O_latipes_ENSORLP00000021561 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011408 LLLPGNRVGAYLIRESETLK----------GGFSLSVRDYDPLHG----------------------DVIKHYKIRS------------------------------------------- A_gambiae_AGAP006219-PA CDIPKCSERMWMYIIIGFVAVISPLFI---GIGVFCCRKYRKHGV----------------------SNIQNINLPN------------------------------------------- G_aculeatus_ENSGACP00000018983 LLAPANKPGSYLIRESETSK----------GSYSLSVRDVGAEGT----------------------DSVKHYKIRT------------------------------------------- C_familiaris_ENSCAFP00000015667 LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG----------------------EVVKHYKIRN------------------------------------------- B_taurus_ENSBTAP00000037887 LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQTQG----------------------EVVKHYKIRN------------------------------------------- M_musculus_ENSMUSP00000100967 LQPPE--DGLFLVRESARHP----------GDYVLCVSFG---------------------------RDVIHYRVL-------------------------------------------- R_norvegicus_ENSRNOP00000027730 LQPPE--DGLFLVRESARHP----------GDYVLCVSFG---------------------------RDVIHYRVL-------------------------------------------- C_elegans_F33E2.2a ELVTQSAPNTPIQHREQANAEFGQKE---------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA LENVEKLIQ-SSGKVLQLTVEHDPEVVDRCRLNNAAG-----EHRYTPVDTNCNNAGLTVVGPGVLKE---------------------------------------------------- X_tropicalis_ENSXETP00000010512 RP-DEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID-----------------------DLIRDQGLQCSEGAPSVQPT-CHRKYHSRDPSPLLHTLPSEIVFDFESDPVCR P_pygmaeus_ENSPPYP00000020565 LLAPINKAGSFLIRESETSK----------GAFSLSVKDVT-TQG----------------------ELIKHYKIRS------------------------------------------- D_rerio_ENSDARP00000095291 ITPLPSPGVSLGHKVLSTSTP---------NVHMVSTTQPVDEAAYQ--------------------EALR-HDE--------------------------------------------- T_rubripes_ENSTRUP00000007128 LLIPGNHRGTFLVRESETTK----------GAYSLSIRDWEEAKG----------------------DNVKHYKIRK------------------------------------------- O_latipes_ENSORLP00000020461 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021875 LLAPGNTQGSFLIRESETTK----------GSYSLSIRDLDHNAG----------------------EGVKHYRIRN------------------------------------------- C_intestinalis_ENSCINP00000011940 LMQPCNQQGAFMVRRRADDR----------NEYALSVMNK---------------------------AKVHHFKIKK------------------------------------------- H_sapiens_ENSP00000259089 LLAPINKAGSFLIRESETNK----------GAFSLSVKDVT-TQG----------------------ELIKHYKIRC------------------------------------------- A_aegypti_AAEL004592-PA LLAAENPRGTFLVRPSEHNP----------NGFSLSVKDWEESRG----------------------YHVKHYKIKP------------------------------------------- T_rubripes_ENSTRUP00000008303 LLSTSNPRGTYLIRESETTK----------GAFSLSIRDWDDMKG----------------------DHVKHYKIRK------------------------------------------- X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 LDDMNCYDKSDCTERKESPDVFFCCCEGNTCNERFYHSPEMEVTQ--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 LDDVNCYDRTECEENREALGVFFCCCEGSLCNKKFSYRPISQSQIT-------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001840 LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG----------------------EVVKHYKIRN------------------------------------------- E_caballus_ENSECAP00000020913 LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG----------------------EVVKHYKIRN------------------------------------------- T_rubripes_ENSTRUP00000030627 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000020756 LLAPANRAGSYLIRESETAK----------GSFSLSVRDVDDGGT----------------------DLVKHYKIRL------------------------------------------- 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ---QKQMPFCDKDRTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS--------LE----------------------VSDTRF------HSFSFYELKNVTNNFD P_troglodytes_ENSPTRP00000008285 ---QKQMPFYDKDRTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS--------LE----------------------VSDTRF------HSFSFYELKNVTNNFD M_mulatta_ENSMMUP00000000286 ---QKQMPFYDKDRTLMTP--L------QNL-----------EQSYMPLDSS--SPENKS--------LE----------------------VSDTRF------HSFSFYELKNVTNNFD E_caballus_ENSECAP00000012782 ---QKQIPLYGKDRTSVIP--V------QNP-----------EQNYVPPDSS--SPENGS--------LE----------------------VSDTRF------HCFSFYELKNVTNNFD C_familiaris_ENSCAFP00000014260 ---QQQMPLNGKDRTFVLP--V------QNF-----------EQNYMPPDSS--SPENTS--------LE----------------------GSDTRF------HSFSFYELKNVTNNFD P_pygmaeus_ENSPPYP00000005053 ---QKQMPFYDKERTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS--------LE----------------------VSDTRF------HSFSFYELKNVTNNFD B_taurus_ENSBTAP00000028115 ---QKPKPLCGKDRTSVIS--D------ENP-----------EQNYVLPDSS--SPENTS--------LE----------------------FSDTRF------HSFSFFELKDVTNNFD R_norvegicus_ENSRNOP00000007932 ---QAHRPCQEKNRTTVTPALA------QKL-----------EPSCELPDSS--SPGHQS--------VE----------------------FSDTRF------HSFSFYELKSITNDFD M_musculus_ENSMUSP00000074471 ---QTHGPCQEKDRTSVMP--M------PKL-----------EHSCEPPDSS--SPDNRS--------VE----------------------SSDTRF------HSFSFHELKSITNNFD M_domestica_ENSMODP00000023115 ---KKLLPPYDKEKTHVKP--V------QNH-----------EHISSSLD-S--SPDRKS--------LE----------------------VSDTRF------QSFSFYELKSVTNNFD G_gallus_ENSGALP00000015600 ---EKQQPIQEKEVTSVKPVLS------QNT-----------EKQPSAPPCL--SQEISS--------TQ----------------------SSNTDF------HNFWFHDLESVTNNFD T_guttata_ENSTGUP00000006104 ---EKQLPVQEKKVASVKPVLA------QST-----------EKHNSGSSYS--SEENSS--------SQ----------------------SSNTDF------QNFLFHDLESITNNFD A_carolinensis_ENSACAP00000002933 ---QITLGTGLKTRTPRKNDFL------LGY-----------VTVFTPPFLF--SEVSTY-----------------------------HFPLLLSGL------QIFLFHELKSFTNNFD T_nigroviridis_ENSTNIP00000019071 ---YSALPTRLLDDAGALA--G------SSS-----------ASTHILPDSR--EPEPSG--------EP----------------------FRNFRL------RSVPYNDLIRITNDFD O_latipes_ENSORLP00000003907 ---EKCPPTLLLGEAPNPP--A------GSS-----------LQTQTLLDDG--GDDTGG--------CKVFSKPYFIIFGQIFLW------HFSDGG------HVFLYGELMRITRNFD G_aculeatus_ENSGACP00000005326 ---KSRLPTRLLEETKTRAPPE------VSV-----------LPSHIPQELS----------------GP----------------------SRAAGF------SSFLYNELMEITGNFD T_rubripes_ENSTRUP00000042842 ---YSALPTRLLDNKGTQT--V------PSS-----------APTQIQLDSC--DPEPTS--------EPSQRNTCF----HVSQWRECSQTYPPLGF------SSISYNDLIKITDGFN O_cuniculus_ENSOCUP00000003553 ---XXXXXXXXXXXXXXXX--X------XXX-----------XXXXXXXXXX--XXXXXX--------XX----------------------XXXXXF------HSFSFYELRSITNDFD O_anatinus_ENSOANP00000003026 ---EKPVPPLDKEKTTTLPGMA------QNH------------EYYSFPDST--SSDTNS--------VE----------------------FSDTRF------HQFSFQELRSVTSNFD C_intestinalis_ENSCINP00000015329 ---EQKSYQVSSSEKSLTRQPT--------------------ENDSALSVGNKLEEEQKSELAFLLQGLNLNANGYYVPTVPILQQRTISKNFNKTDIYSFCSVSPYSYSSLKMLTSDFN X_tropicalis_ENSXETP00000014885 ---ASTRPVSSAINAPCEMSAA----------------EVIDTCNPHTYQSK--GPEENE-----------------------------VDDFDDMGI------GRFSFTEVKQSTNNFD D_rerio_ENSDARP00000023777 ---QACEITQTVEDNSNKPQKI------SKPVEDDSNKPVQEQELFVEPDSS--SGAQES--------SW----------------------DSSQGF------HTFSLHELTAMTQHWD T_guttata_ENSTGUP00000010778 ---PAGSAVSAGALYSLPAPPP------PPR-----------DLLNSL--QS--NPPVLSSVK--PCSSS--------------TPQQETMADLLSGS------LLWTQREIANATNSFS H_sapiens_ENSP00000358997 ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-PG--------P--------------ESSVSLLQGARPFP------FCWPLCEISRGTHNFS P_pygmaeus_ENSPPYP00000023353 ---AFPGSQTHAG-PELGVVPS------PAS-----------LRPPPPSPAP--SSTK-PG--------P--------------ESSVSLLQGAHPSP------FCWPLCEISQGTHNFS B_taurus_ENSBTAP00000021407 ---AFPGSQTHSD-PELCPGPS------PAA-----------HQPPLPSPAP--SSTK-PS--------P--------------ESPMSLLPGAPSSS------FCWPLHEICQGTHDFS C_elegans_K09B11.1 ---QSASRLKKTEIKESSPSPA--------------------AAAASQLSRS---------------------------------NTDDTLRVAIEGT------LPVTYCELLEATNGFA C_familiaris_ENSCAFP00000000535 ---LN-PSEQSHQRDGFPNMLP------K--------------ETANVTTDN--VLT--PKHNEKGILFK----------------------------------SSISFQNIRDGTKNFH D_rerio_ENSDARP00000092301 ---PVPGNMF----PEIRPLPR------PS--------------PPPPDSVS--STISKTT--------E--------------EVFCLNPPPLSSSA------MSWPFEEIQRGTCNFS G_gorilla_ENSGGOP00000000218 ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-PG--------P--------------ESSVSLLQGARPSP------FCWPLCEISRGTHNFS E_caballus_ENSECAP00000007763 ---AFPGSQTHSG-PELGPVPS------LAA-----------LRPPPASPAP--SSTK-QS--------P--------------ESQLSLLQGAHPSP------FCWPLHEISRGTHNFS M_mulatta_ENSMMUP00000026705 ---AFPGSQTHSG-PELGLVPS------PAS-----------LRPPPPSPAP--SSTK-PG--------P--------------ESSVSLLQGAHPSP------FCWPLCEISQGTHNFS O_anatinus_ENSOANP00000017468 ---CFPGGSLQSK-PVL--IPT------PTS-----------LHPPPPRPCP--GRTD-PSVRFLQQKEE--------------RSCFSELAGGR-AP------FRWPFPEVSQGTRNFS X_tropicalis_ENSXETP00000031192 ---PSDLPQQ----LPL-PGPP------PKA-----------FICSSHSAST--GGSSDCSGSQIHSSVQ--------------ESFLPSDVRDLPRQ------FVWRFQELVDGTRNFS R_norvegicus_ENSRNOP00000005686 ---WT-PPVQTHHELRFPNLPP------NSKPVCRESDPGPL-ELANVTVDN--VLV--PEHNERVVLHK----------------------------------TPISFQSILEGTKHFH M_musculus_ENSMUSP00000033769 ---AFPGSQTHSE-SELLQVPL------PVS-----------LGPPLPSSAP--SSTKQSS--------P--------------ESPVSGLQRAHPSP------FCWPFCEISQGTCNFS G_aculeatus_ENSGACP00000001480 ---FILKGFQSSRSAVVQVPPM------KKE-----------EDPSPDRPLP----------------PP--------------FCTLTSLKLPSSGV------MCWSYEEVHAGTGGFS A_carolinensis_ENSACAP00000012253 ---PSPGSQGAAG-APLRLGTT------PMA-----------YWQQTLCGQS--SSSSSSS-----------------------SSSRLGSSLSLTCP------FEWRLEELRQATSDFS M_domestica_ENSMODP00000037830 ---GFPSDSWPSPCPPSSPAPQ------RAA------------GPLSSNTSS--SSTK-QG--------E--------------ENKISPVEYASPPP------FRWPLLEITQATHNFS R_norvegicus_ENSRNOP00000053167 ---AFPGSQTHSE-SELLQVPL------SDS-----------LGPPLQSSAP--SSIKQPS--------P--------------ESPVSGLQRARPSP------FCWPFCEISQGTCNFS M_musculus_ENSMUSP00000020448 ---WT-PSVQTHHELPFPSFPP------EVKHACRENDPGPL-EPANVTVDN--VLV--PEHNEKGTLQK----------------------------------TPISFQSILEGTKHFH B_taurus_ENSBTAP00000033611 ---LN-PIEQSHREKEFPNMLQ------KVECVCVDNDPCKLEETANVTVDN--VLI--PERNEKGILLK----------------------------------SSISFHSIVEGTKNFH A_gambiae_AGAP002966-PA ---NANVPNGHRAAHRLKDGAA------DQKVNGGGGDGAAAAAAAATNDKS--NPTNSKENSPFANELA----------------------DLTSLI------PKISYEELTAATDNWS C_familiaris_ENSCAFP00000028744 ---AFPGSQTHSG-AELGPVHS------PGI-----------LQPPPPRPAP--SSTK-PS--------A--------------ESPASLLQGAHPSP------FCWPLSEISQGTHNFS P_troglodytes_ENSPTRP00000008814 ---LS-PSEKSYQEGGFPNILF------K--------------ETANVTVDN--VLI--PEHNEKGILLK----------------------------------SSISFQNIIEGTRNFH H_sapiens_ENSP00000261233 ---LS-PSEKSYQEGGFPNILF------K--------------ETANVTVDN--VLI--PEHNEKGILLK----------------------------------SSISFQNIIEGTRNFH M_mulatta_ENSMMUP00000021862 ---LS-PSEKSYQEGGFPNILL------K--------------ETASVTVDN--VLI--PEHNGKGILPK----------------------------------SSISFQNIIEGTRNFH T_rubripes_ENSTRUP00000016336 ---ALNVSLLVPRASTVAQQCI------DAT-----------PQPSIMYG-P--ETHQ-GC--------P--------------NFLQRGPDLITSGL------MCWSYEEVHAGTKGFS A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------KFSTSPVV------AVYAYDHLREVTDGFN P_pygmaeus_ENSPPYP00000005399 ---LS-PSEKSYQEGGFPDILF------K--------------ETANITVDN--VLI--PEHNEKGILLK----------------------------------SSISFQNIIEGTRNFH O_anatinus_ENSOANP00000009429 ---LNISPSQTCQRDGFQSRAS------K--------------KTADSAVGN--EVLSPPKYQHQGIRPK----------------------------------ASIDFKSIIEGTGNFH G_gallus_ENSGALP00000035437 ---PACNAVSEGTLYSLPSPPP------PPR-----------DLLKSL--QS--NPSVSSSVK--PCSSS--------------TPQQETMTDLPSGS------LLWTQKEVTNATDGFS P_troglodytes_ENSPTRP00000038647 ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-PG--------P--------------ESSVSLLQGARPSP------FCWPLCEISRGTHNFS P_pygmaeus_ENSPPYP00000015274 ---PGPGSSPARAHQPA-FLQP------PEE-----------DAPHSL--RT--DLPTSSDSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN E_caballus_ENSECAP00000010808 ---PGSKSSVSRGPWPA-LLPL------PPE-----------DASSAL--NT--EPPASSDSK--DFSAS--------------IPEEETLLSLAGDS------LFWSEADVVQATDNFN T_nigroviridis_ENSTNIP00000007783 ---GCCSSSKGNTWSLLKVHKL------QSE-----------IQPPAPPGQP--HTQPSIA-----------------------------EASCTSGL------MCWSYEEVHAGTKEFS D_rerio_ENSDARP00000067130 ---CVLKSSSPPHYPTYLRSTG--------------------KSCQVSDLHA--ESVSVEGEKQK---------------------------------------CFITYFDVIEGTRHFH P_troglodytes_ENSPTRP00000025212 ---PGPGSSPARAHQLA-FLQP------PEE-----------DAPHSL--RS--DLPTSSDSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN H_sapiens_ENSP00000256458 ---PGPGSSPARAHQPA-FLQP------PEE-----------DAPHSL--RS--DLPTSSDSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN D_melanogaster_FBpp0084549 ---LRAAPDSSAKVNNGPPFPS---------------------SSGVSNSNNNRTSTTATEEIPSLESLG--------------NIHISTVQRAAESL------LEIDYAELENATDGWS C_familiaris_ENSCAFP00000007680 ---PGPGILMAKNQRASTVMKA------CAT-----------DAPHSL--KT--DVPVSSNSK--DFSTS--------------IPKQETLLSLAGDS------LFWSETDVVQATDNFN M_mulatta_ENSMMUP00000026192 ---PGPGSSPARAHQQA-FLQP------REE-----------DAPHSL--RT--NLPTSSDSK--DYSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN M_domestica_ENSMODP00000033729 ---PSSSSGPSGCSNRVLQLPF------IED-----------DLPHSL--KT--N-PSTSDIK--NCHAY--------------ITQHQPLLSLNGES------LYWTEMEVIKATNGFG A_aegypti_AAEL007642-PA ---LSIFGPAASEASMDVGIPAISALMASSDSQQIVNDVSRSTETFQSEEHSSESSSSDSTEQQSSNNEP--------------VCASNLMAFSSTNVATVEPLINFSFDSLTTATGNFD T_guttata_ENSTGUP00000014323 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ---PGSGPAAVRV-----NLPA------PPE-----------DASSSL--KT--NQTASADSK--DFSAS--------------IPKQETLSSLAGDD------LFWSEVDVIQATDNFN M_musculus_ENSMUSP00000055073 ---LDTGPIMAGAQRQ----RP------CEM-----------DAPCSL--KT--DAPDSPQSKYCSTSTS--------------APKQERLLGLPGDR------LFWSEADVVQATEDFD A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ---LS-PSEKSYQEGGFPNILF------K--------------XXXXXXXXX--XXX--XXXXXXXXXXX----------------------------------XXXXXXXXXXXXXXXX G_aculeatus_ENSGACP00000025500 ---SSSSSTSGPAIRTWSNSTS---------------------LPAHSALHL--PMTSAEENKP----------------------------------------PVITFQDIIDGTRNFH T_guttata_ENSTGUP00000011997 ---GSAAGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- O_anatinus_ENSOANP00000021129 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- G_gallus_ENSGALP00000020950 ---GSTAGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- B_taurus_ENSBTAP00000029006 ---GSTTGLSATPPASLPGSLS------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- E_caballus_ENSECAP00000003689 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- X_tropicalis_ENSXETP00000003054 ---PLPAP------------PP------PPS-----------DLLHSLSIQS--ECSLTCHSP--EEVLS--------------IPQQEKSSFSKGLC------KIWTQKDVEDATDCFC H_sapiens_ENSP00000288602 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- P_troglodytes_ENSPTRP00000033866 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- C_familiaris_ENSCAFP00000005841 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- P_pygmaeus_ENSPPYP00000020265 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- M_musculus_ENSMUSP00000002487 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERKSSS----------SSSS-----------------EDRSRMKTLGRR------DSSDDWEIPDGQITV- R_norvegicus_ENSRNOP00000014604 ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----------SSSSS--------------STEDRSRMKTLGRR------DSSDDWEIPDGQITV- A_carolinensis_ENSACAP00000011088 ---GSTTGLSATPPASLPGSLT--------KALQ-------KSP-GPQRERK--S----------SSSS-----------------DDRTRMKTLGRR------DSSDDWEIPDGQITV- T_nigroviridis_ENSTNIP00000000196 ---PSPKLSTSPTSSLGSPGRR--------P--I-------KSP-SENKERK--P-----------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVAI- T_rubripes_ENSTRUP00000004441 ---IHTLTMVGPPSSFGSPGRR--------P--P-------KSP-SEQKERK--P-----------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVTI- D_melanogaster_FBpp0079568 ---ADKNIYGNSQLN--------------------------NAQDAG-------RGNLGNLSDHVALNSK--------------L-----IE----RN------TLLRINHFTLQDVEF- O_latipes_ENSORLP00000020929 ---PSPKPSTSPPSFLGSPGKK--------P--P-------KSP-SEHKERK--P-----------SSS-----------------DDKKKVHRGN-R------DSSYYWEVHSREVQI- O_cuniculus_ENSOCUP00000012185 ---GSPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- G_aculeatus_ENSGACP00000000078 ---------GSSPSQ-SPTGWS--------Q--S-------KAPAPAQRERA--P----------SFNN-----------------HEKNKIRPRDKR------DSSYYWEIEASEVHL- A_carolinensis_ENSACAP00000011023 --------------------------------------------------------------------------------------------KSLGYR------DSSYYWEVSPKEVTM- R_norvegicus_ENSRNOP00000013831 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- H_sapiens_ENSP00000251849 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- M_mulatta_ENSMMUP00000009777 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- P_pygmaeus_ENSPPYP00000014975 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- E_caballus_ENSECAP00000010011 --------LSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- M_musculus_ENSMUSP00000108571 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- C_familiaris_ENSCAFP00000007376 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- O_latipes_ENSORLP00000012350 ---GSTTGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----------SSSS-----------------EDRNKMKPLGRR------DSSDDWEIPEGQITL- B_taurus_ENSBTAP00000005930 ---GSPSALSSSPNNLSPTGWS--------Q--P-------KTPAPAQRERA--P----------GSST-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- M_domestica_ENSMODP00000007826 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAHRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- G_gallus_ENSGALP00000007991 ---ASPSALSGSPNNMSPTGWS--------Q--P-------KTPVPAQRERA--P----------GTNT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- D_rerio_ENSDARP00000048390 AMPGSTTGLSATPPASLPGSLP------NVKV-S-------KSP-CQPRERK--P----------SSSS-----------------EDRNKMKTLGRR------DSSDDWEIPEGQITL- M_domestica_ENSMODP00000011339 ---ISASTKQSQQSAGFPNIPS------Q--------------VPTDSTIDK--QGE-MPEY-RKEIRLK----------------------------------PSFNFKSIIEGTKNFH G_aculeatus_ENSGACP00000004834 ---PSPKPSTSPPSSLGSPGRR--------P--P-------KSP-SEHKERK--P-----------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHSREVTI- A_carolinensis_ENSACAP00000013056 ---ASPPAISSSPNNTSPTGWS--------Q--S-------KTPVPAQRERA--S----------GSNA-----------------QEK-KIRPRGQR------DSSYYWEIEASEVML- T_nigroviridis_ENSTNIP00000010036 ---GSTTGLSATPPASLPGSLT------NVKIPQ-------KSP-CQQRERK--S----------SSSS-----------------EDRSKMKTLGRR------DSSDDWEIPEGQITL- T_rubripes_ENSTRUP00000029372 ---GSTTGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----------SSSS-----------------EDRSKMKTLGRR------DSSDDWEIPEGQITL- D_rerio_ENSDARP00000044241 ---------GSSPNQ-SPTGWN--------QASA-------HIP-------A--S----------ALNP-----------------QEKVKIRPRDKR------DSSYYWEIEANEVVL- P_troglodytes_ENSPTRP00000025252 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- T_rubripes_ENSTRUP00000016249 ---------GSSPNQ-SPTGWS--------QSQS-------KAPAPSQRERA--T----------SFNT-----------------QEKNKIRPRDKR------DSSYYWEIEASEVYL- G_aculeatus_ENSGACP00000025456 ---GSTAGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----------SSSS-----------------EDRNKMKTLGRR------DSSDDWEIPEGQITL- T_nigroviridis_ENSTNIP00000015593 ---------GSSPNQ-SPTGWS--------QSHS-------KAPAPSQRERA--T----------SFNT-----------------QGEHKIRPRDKR------DSSYYWEIEASEVYL- T_rubripes_ENSTRUP00000004702 ---MDNGGYYISPKITFNDISS------MIKHYH-------NKADGLCRNLD--R----------PCVKP--------------K-----AQ----KP------WDKDAWEIPKECIKM- A_gambiae_AGAP011710-PA ---EEPTPSKCEILMLLSHLPP--------------------TATNSLKEKERSSSMSRLLDEHRTMATG--------------GEFYDLSRTKSFRV------EPKAARIFRASDLVQ- O_latipes_ENSORLP00000014365 ---------GSSPNQ-SPTGWS--------HSQS-------KTPTPAQRERA--P----------SFTA-----------------QEKNKIKPRDKR------DSSYYWEIEASEVYL- D_rerio_ENSDARP00000008826 ---LDNGGYYISPSTSFSSLQE------LVKYYS-------RTADGLCQRLG--N----------PCKST--------------A-----PQ----RP------WAQDEWEIPRETLKL- E_caballus_ENSECAP00000003552 ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----------GSGT-----------------QEKNKIRPRGQR------DSSCYWEIEASEVML- D_rerio_ENSDARP00000071167 ---SSPKPSTSPP-HLGSPGRK--------P--P-------KSP-SEPKERK--Q-----------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVSM- C_familiaris_ENSCAFP00000011788 ---LDEGGYYISPRITFPTLQA------LVQHYS-------QKGDGLCQRLT--Q----------PCVSL--------------A-----PQ----NP------WAQDEWEIPRQSLKL- O_latipes_ENSORLP00000015921 ---LDNGGFFISPKISFNDIGS------MVKHYH-------SKADGLCRKLE--S----------PCVKP--------------K-----AQ----KP------WAKDAWEISKDSIKM- O_anatinus_ENSOANP00000008740 ---LDNGGYYISPRITFTCISD------MIKHYQ-------KQSDGLCRRLE--K----------VCISP--------------K-----PQ----KP------WDKDAWEIARESIKL- O_latipes_ENSORLP00000021561 --------------------------------------------------------------------------------------------------------ASAPQTSLHMRPTDLI M_domestica_ENSMODP00000011408 ---LDNGGYYISPRITFPTITD------LIKHYQ-------RQPDGLCRRLD--K----------ACIST--------------Q-----PQ----KP------WDKDAWEIPRESIKL- A_gambiae_AGAP006219-PA ---ADKNIYGNSRLNSPIEMTS------LIANQSSTGAASRNAENGGIQGLT--TGQPGN--GHNPGQSS--------------Q-----SR----NN------GISRVPQYTLQDVRF- G_aculeatus_ENSGACP00000018983 ---MDDGGYYISPKISFPSIAA------MIKHYH-------HKADGLCRKLD--R----------ACVKP--------------Q-----AQ----KP------WDKDAWEISKNSIKM- C_familiaris_ENSCAFP00000015667 ---LDKGGFYISPRITFPGLHE------LVRHYT-------NSSDGLCTRLS--R----------PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- B_taurus_ENSBTAP00000037887 ---LDKGGFYISPRVTFPGLHE------LVRHYM-------NTSDGLCTRLS--R----------PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- M_musculus_ENSMUSP00000100967 ---HRDGHLTIDEAVCFCNLMD------MVEHYT-------KDKGAICTKLV--------------------------------KPRRKQGAKSAEEE------LAKAGWLLDLQHLTL- R_norvegicus_ENSRNOP00000027730 ---HRDGHLTIDEAVCFCNLMD------MVEHYT-------RDKGAICTKLV--------------------------------KPKRKQGAKSAEEE------LAKAGWLLDLQHLTL- C_elegans_F33E2.2a ---GSPDPKNMVAATGNASKPS------LNSFYA--------------------DGLGQLRNGLFSCFQP-------------VFGYFGTKTTVEIEK------SEDELWEIPFDAISE- C_intestinalis_ENSCINP00000023589 -----------------------------------------------------------------------------------------------------------SFVRVRYEDLQF- A_aegypti_AAEL000187-PA ---RSPSPNKYDKERMFKKKDEGYMSGTTRKLQKRLKDVNCNNASNSLKEKERSSSMSKLLDEYQHHHHS--------------GDFYDLSRTKSFRV------EQKAARIFRASDLVQ- X_tropicalis_ENSXETP00000010512 ---GSTPGLSATPPASLPGSLT------NVKALQ-------KSP-GQQRERK--S----------SSSS----------------TEDRSRMKTLGRR------DSSDDWEIPDGQITSS P_pygmaeus_ENSPPYP00000020565 ---LDGGGYYISPRITFPSLQA------LVQHYS-------KKGDGLCQRLT--L----------PCVSP--------------A-----PQ----NP------WAQDEWEIPRQSLRL- D_rerio_ENSDARP00000095291 ---------SGSPQNLSPTEW------------S-------KTPAPAHREKA--P-----------SSN-----------------TQEKRIRPREKR------DSSYYWEIEATEVLL- T_rubripes_ENSTRUP00000007128 ---LDSGGYYITTRVQFDALQK------LVKHYT-------EHADGLCHRLT--T----------VCPTV--------------K-----PQTQG---------LAKDAWEIPRESLRL- O_latipes_ENSORLP00000020461 ---GSCEHHGGECRPGHPHHPD--------------------DIKLHFHRAG--PGSGGFLEGLFGCLRP-------------VWNIIGKTYSTEYKL------QQQDMWEVPFEEISE- O_latipes_ENSORLP00000021875 ---LDSGGFYITAKISFNSLKE------LVQHYT-------READGLCSTLG--K----------PCQSR--------------A-----PQ----KP------WWHDEWEIPRESLKL- C_intestinalis_ENSCINP00000011940 ---SSQG--YLMGGIEFITLDE------LVAFYK-------KNLVGDIARLG--S----------PCKQS--------------QMVVESPQTIGLSH------DIVDEWEIDRNSIQL- H_sapiens_ENSP00000259089 ---LDEGGYYISPRITFPSLQA------LVQHYS-------KKGDGLCQRLT--L----------PCVRP--------------A-----PQ----NP------WAQDEWEIPRQSLRL- A_aegypti_AAEL004592-PA ---LDNGGYYIATNQTFPSLPA------LVLAYS-------KNALGLCHVLS--S----------PCPKP--------------Q-----PQVWDLGP------ELRDKWEINRNEIQL- T_rubripes_ENSTRUP00000008303 ---LDSGGYYITTRAQFETLQQ------LVQHYS-------DRAAGLCCRLV--V----------PCHKG--------------M-----PRLADLSI------KTKDVWEIPRESLQL- X_tropicalis_ENSXETP00000003560 --------------------------------------------------------------------------------------------------------GNADARPCFLGDLEG- X_tropicalis_ENSXETP00000046976 ---PTSNPVPTKPPLFNTLLYSLVPIMVVAVIVLFSFWMYRHHKLAYPPVLV--PTQDPG--------------------------------------------PPPPSPLLGLKPLQL- T_nigroviridis_ENSTNIP00000019431 -------------------------------------------ADGLCQRLF--A----------PCKPK--------------A-----FQ----QP------WAQDEWEIPRDTLKM- T_rubripes_ENSTRUP00000004157 ---TTTKPVTARAQLLTTLMYSLLPVMAVGAVLLFSLWLYRQHKRAYPPVLV--PTQEPH--------------------------------------------PPPPSPSLSQRPLQL- P_pygmaeus_ENSPPYP00000001840 ---LDNGGFYISPRITFSGLHE------LVRHYT-------NASDGLCTRLS--R----------PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- E_caballus_ENSECAP00000020913 ---LDKGGFYISPRITFPGLHE------LVRHYT-------NASDGLCTRLS--R----------PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- T_rubripes_ENSTRUP00000030627 -----ASYHSEEGKQGHHHQPE--------------------DIKLHFHRAG--PGSGGFLEGLFGCLRP-------------VLNIIGKTYSTEYKL------QQQDMWEVPFEEISE- T_nigroviridis_ENSTNIP00000020756 ---LDNGGYYISPKISFTDISS------MIKHYH-------SKADGLCRKLD--R----------PCVKP--------------K-----AE----KP------WDKDAWEISKDSIRM- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAAMVDIT---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG P_troglodytes_ENSPTRP00000008285 ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAAMVDIT---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG M_mulatta_ENSMMUP00000000286 ERPISVG------GNKMGEGGFGVVYKGYVN--------NA--T----VAVKKLAAMVDIT---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG E_caballus_ENSECAP00000012782 ERPVSIG------GNKMGEGGFGVVYKGYVN--------NR--M----VAVKKLAAMVDIS---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG C_familiaris_ENSCAFP00000014260 ERPISLG------GNKMGEGGFGVVYKGYVN--------NK--T----VAVKKLAAMVDIS---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG P_pygmaeus_ENSPPYP00000005053 ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAA-------------------------------CQHENLVELLGFSS----DGDDLCLVYVYMPNG B_taurus_ENSBTAP00000028115 ERPISVG------GNKMGEGGFGVVYKGYVN--------NR--T----VAVKKLAAMVDIS---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG R_norvegicus_ENSRNOP00000007932 ERPVSIG------GNRMGEGGFGVVYKGCVN--------NT--T----VAVKKLGAMVEIS---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DSDNLCLVYAYMPNG M_musculus_ENSMUSP00000074471 EQPASAG------GNRMGEGGFGVVYKGCVN--------NT--I----VAVKKLGAMVEIS---TE--ELKQQFDQEIKVM--AT--CQHENLVELLGFSS----DSDNLCLVYAYMPNG M_domestica_ENSMODP00000023115 ERPMSAG------GNKMGEGGFGVVYKGCIN--------SR--T----VAVKKLTRMTDMC---TE--ELKQQFDQEIKIL--AK--CQHENLVQLLGFSS----DSNDFCLVYVYMPNG G_gallus_ENSGALP00000015600 ERPESAG------GNKLGEGGFGIVFKGYIN--------GR--N----VAVKKLAAVVDVS---AQ--DLKQQFDQEIEIM--AK--CKHENLVELLGFSS----DGAQPCLVYEYMPNG T_guttata_ENSTGUP00000006104 ARPESAG------GNKLGEGGFGIVFKGYIN--------GK--N----VAVKKLIAMVDVS---VQ--DLKQQFEQEINIM--AK--CQHENLVELLGFSS----DGAQPCLVYEYMPNG A_carolinensis_ENSACAP00000002933 DRTVSAG------GNKIGEGGFGVVYKGCTN--------GR--T----VAVKKLTVLADVS---ID--DLKKQFEQEITIM--AK--CQHENLVELLGFSN----DFDQPCLVSDYMPNG T_nigroviridis_ENSTNIP00000019071 DRPVSDG------GCRLGEGGFGAVYKGVLN--------QI--P----VAVKKLVPIEDIS---LE--ELRVQFHQEVQTL--RV--LKHENLVDMVGFSC----DGQYPCVIYPLMSNG O_latipes_ENSORLP00000003907 DRSISDG------GSRIGAGGFGTVYKGLLD--------SR--L----VAVKKLSPMEDMP---LE--SLQLQFNQEIQTL--KV--LKHQNLVDMVGFSS----DEQHLCIVYALMANG G_aculeatus_ENSGACP00000005326 DRPISDG------GSRLGEGGFGTVYKGLLH--------DR--P----VAVKKLNPMDDIS---LD--ELQVQFNQEIQAL--RV--LKHENLVDMVGFSC----DGQHPCLVYALMVNG T_rubripes_ENSTRUP00000042842 DRPVSEG------GCRLGEGGFGAVYKGVLN--------HK--L----VAVKKLIPVEDMS---LE--DLQIQFHQEIQTL--TV--LQHENLVDMVGFSC----DGQYPCVIYPLMPNG O_cuniculus_ENSOCUP00000003553 ERPIARG------GNKMGEGGFGVVYKGCLR--------NT--P----VAVKKLAAMVDIS---TE--ELKQQFEQEIKVM--AX--XXXXXXXXXXXXXX----XXXXXXXXXXXXXXX O_anatinus_ENSOANP00000003026 ERPISIG------GNKMGEGGFGVVYKGSIS--------NR--V----VAVKKLAAMVDIS---TQ--ELKQQFDQEIKTM--AK--CRHENLVELIGFSS----DGDDLCLVYVYMPNG C_intestinalis_ENSCINP00000015329 D------------SLKLGEGAFGSVFQGHLTQPKDGDSLER--K----IAIKRLKLDTPEF---AT--AITEQFKKEVHVI--SE--LQHENILPLMGYSC----DGPELCLVYDYMFNG X_tropicalis_ENSXETP00000014885 IRPVSEG------GNKLGEGGFGVVFKG-------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000023777 ERPLSDG------GCRLGSGGFGVVFRGRMG--------DK--H----VAVKKLNPLDGSS---YE--DLRKQFNQEIQTL--R------------------------------------ T_guttata_ENSTGUP00000010778 D------------KNRICEGTFADIYKGQRN--------NM--V----FVIKRLKEAMLECTS-PD--STQRFFHTEVQIC--FR--CCHINILQLLGFSV----ETGSHCLIYPYLPNG H_sapiens_ENSP00000358997 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKENADLE---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG P_pygmaeus_ENSPPYP00000023353 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADLE---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QSGFYCVVYGFLPNG B_taurus_ENSBTAP00000021407 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEEADLE---WT--TVKQSFQTEVQQL--SR--FRHPNIVDFAGYCA----QSGFYCLVYGFLPNG C_elegans_K09B11.1 V------------SNVIGKGGYGTVYKGELK--------GTGGI----VAVKRLHSGNDTSQNGSR--ERLRQSLTELRTL--AR--FRHDNILPIYAYSL----EGSEPCLVYQFMSNG C_familiaris_ENSCAFP00000000535 K------------DFLIGEGEIFEVYRAEIQ--------NR--T----YAIKLFKQEKKMQ---CK--KQWKRFLSELEVL--LL--FHHPNILELAAYFT----ENEKFCLVYPYMRNG D_rerio_ENSDARP00000092301 P------------CKQIGEGGFGHVYKAVMR--------NT--E----FAVKKLKEDSHLD---WN--VVKESFRTEVDKL--SQ--YRHPNIMDFVGYCI----SGQTYCVIYVYMPNG G_gorilla_ENSGGOP00000000218 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADLE---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG E_caballus_ENSECAP00000007763 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEEADLE---WT--TVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QTGCYCLVYGFLPNG M_mulatta_ENSMMUP00000026705 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADLE---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG O_anatinus_ENSOANP00000017468 E------------QLKIGEGGFGCVYRATMR--------NT--E----YAVKKLKEDAELE---WS--VVKKSFVTEVEKL--SR--FRHPNIVDFAGYCV----EGGLYCLVYVFLPNG X_tropicalis_ENSXETP00000031192 Q------------SLLIGEGGFGCVYKATMR--------NT--E----YAVKRLKQDSELE---WS--TMKKSFLTEIEKL--TC--LRHPNIIDLAGYSF----QGEEYCLIYLYLPNG R_norvegicus_ENSRNOP00000005686 K------------DFLIGEGEIFEVYRVEIR--------NQ--T----YAVKLFKQEKTMQ---LK--KHWKRFLSELEVL--LL--FNHPHILELAAYFT----EMEKLCLVYPYMSNG M_musculus_ENSMUSP00000033769 E------------ELRIGEGGFGCVYRAVMR--------NT--T----YAVKRLKEEADLE---WT--MVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGLYCLVYGFLPNG G_aculeatus_ENSGACP00000001480 P------------SLQVGEGGFGVVYRASLR--------NT--D----CAVKRLKQDCLLD---WI--QLRESFQNEVDQL--SK--FRHPHIVDLLGFSE----GPETVCLIYSYMELR A_carolinensis_ENSACAP00000012253 E------------NLKIGEGGFGCVYQARLR--------NT--I----YAVKRLKEEAELD---WS--VIKNSFVTEVEKL--YR--FRHPNIVELAGYCA----EQGNFCLVYVFLPKG M_domestica_ENSMODP00000037830 E------------ELKIGEGGFGCVYRAVMR--------NT--S----YAVKRLKEDAELE---WN--TIKTSFGTEVEKL--SR--FRHPNIVDFAGYCI----QDNVYCLVYVFLPNG R_norvegicus_ENSRNOP00000053167 E------------ELRIGEGGFGCVYRAVMR--------NT--T----YAVKRLKEEADLE---WT--VVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGFYCLVYGFLPNG M_musculus_ENSMUSP00000020448 K------------DFLIGEGEIFEVYRVDIR--------NQ--A----YAVKLFKQEKKMQ---LK--KHWKRFLSELEVL--LL--FRHPHILELAAYFT----ETEKLCLVYPYMSNG B_taurus_ENSBTAP00000033611 K------------DFLIGEGEIFEVYRVEIQ--------NR--T----YAIKLFKQGGKMQ---CK--KQWKRFLSELEVL--LL--FRHPNILELAAYFT----ESEKFCLVYPYMRNG A_gambiae_AGAP002966-PA E------------RNILGKGGFGTVYRGNFK--------HT--F----MAIKKIDYNKVKSSE-AERIQLQQSF-NELRFL--NS--CRHDNIVPLFGYCI-----EKEPCLVYQFMPGG C_familiaris_ENSCAFP00000028744 D------------KLKIGEGGFGCVYRAVMR--------NT--L----YAVKRLKEGADLE---WT--TVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGFYCLVYGFLPNG P_troglodytes_ENSPTRP00000008814 K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKMQ---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG H_sapiens_ENSP00000261233 K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKMQ---CK--KHWKRFLSELEVL--LL--FHHPNILELAAYFT----ETEKFCLIYPYMRNG M_mulatta_ENSMMUP00000021862 K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKMQ---CK--KHWKSFLSELEVL--LL--FHHPNILELTAYFT----ETEKFCLVYPYMRNG T_rubripes_ENSTRUP00000016336 P------------TLQVGEGGFGVVYKATLS--------NT--V----CAVKVLKEDRLLD---WK--VLNQSFQTEMEKL--SK--FRHPNIVDLLGFSK----GPGTVCLIYSYMENK A_gambiae_AGAP003062-PA VAPYTNGNLAAPNGRSLGAGGFGAVFLALNL--------AP--S----IPVAAVKRLDPDK------YKFREKFHLELDIL--SK--HSHTNVVSLLGSSS----DGPQLCLVYEYLKDG P_pygmaeus_ENSPPYP00000005399 K------------DFLIGEGEIFEVYKVEIQ--------NL--T----YAVKLFKQEKKMQ---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG O_anatinus_ENSOANP00000009429 G------------DLLIGEGEFFQVYRMEFE--------NQ--T----YAIKLFKQEKTMQ---SK--KYWKPFFSELEVL--LL--FHHPNILELTAYFI----EAERFCLVYPFMRHG G_gallus_ENSGALP00000035437 G------------KNRICEGTFADVYKGQRH--------NM--V----YVIKRLKEAITECTS-PN--STQRFFHTEVQIC--FR--CCHVNILQLLGFTV----ESELHCLIYPYLPNG P_troglodytes_ENSPTRP00000038647 E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADLE---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG P_pygmaeus_ENSPPYP00000015274 Q------------NHKISQGTFADVYRGYRH--------GT--P----FVFKKLRETACSS---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG E_caballus_ENSECAP00000010808 Q------------NHKISEGTFADVYRGHRH--------GE--P----FVFKKLREASTSCLPVRR--SIKKFFQAEVQIC--HR--CCHPNVLPLLGFCT----GGQFHSLVHPYMANG T_nigroviridis_ENSTNIP00000007783 P------------TLQVGEGGFGVVYKATLR--------NT--V----CAVKVLKQDRLLD---WK--LLKESFRTEMEKL--SK--FRHPNIIDLLGFSE----GPGTVCLIYNYMENK D_rerio_ENSDARP00000067130 Q------------DLKIGGSGFAEVYCGRWG--------NR--S----FAVKVFKQENKTD---WK--ALWEKFTKEIEVL--QL--NQHPNILELWGSFS----DSDRFCLVYPFLQNG P_troglodytes_ENSPTRP00000025212 Q------------NHKISQGTFADVYRGHRH--------GK--P----FVFKKLRETACSS---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG H_sapiens_ENSP00000256458 Q------------NRKISQGTFADVYRGHRH--------GK--P----FVFKKLRETACSS---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG D_melanogaster_FBpp0084549 P------------DNRLGQGGFGDVYRGKWK--------QL--D----VAIKVMNYRSPNI---DQKMVELQQSYNELKYL--NS--IRHDNILALYGYSI----KGGKPCLVYQLMKGG C_familiaris_ENSCAFP00000007680 Q------------NYKISEGNFADIYKGQKH--------GT--L----FVFKKLREAAYSG---PG--SIEKFFQAEVQIC--HR--CCHPNILPLLGFCT----GNQLYILIYPYMANG M_mulatta_ENSMMUP00000026192 Q------------NHKISQGTFADVYRGHRH--------GT--P----FVFKKLRETACSS---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG M_domestica_ENSMODP00000033729 Q------------ENKISQGTFADVYKGQRH--------NI--T----YVFKKLQKASTRC---PRNLSVESFFHMEVQIC--LR--CSHQNILPLLGFCT----GEVFHSVIHPYMPNG A_aegypti_AAEL007642-PA IKRFSNGNPLQPDGRVLGIGGFGEVFLALNL--------TP--T----YPVSAVKRLFPTN------YKYKEKFDRERELL--SK--YNHSNIVELIGFS-----ENVTLCLVYEYLPDG T_guttata_ENSTGUP00000014323 -------------------------------------------------------------TS-PD--STQRFFHTEVQIC--FR--CCHINILQLLGFSV----ETGSHCLIYPYLPNG B_taurus_ENSBTAP00000008135 P------------SHKISEGTFADVYRGHKR--------GT--P----FIFKKLREMACSG---PG--SVEKFFQAEVQIC--RR--CCHPNVLPLLGCCT----GEQFYSLIYPYMANG M_musculus_ENSMUSP00000055073 Q------------SHRISEGTFADIYQGQRN--------GV--A----FAFKKLREVAGSS---PG--SMDRFLQAEMQLC--LR--CCHANVLPLLGFCT----GRQFHSLIYPYMANG A_carolinensis_ENSACAP00000014667 --------------------------------------------------------------------------------C--YR--CHHPNILQLLGFSV----ESVSPCLIYPYMPNG G_gorilla_ENSGGOP00000006760 X------------XXXXXXXXXXXXXXXXXX--------XX--X----XXXXXXXXEKKMQ---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG G_aculeatus_ENSGACP00000025500 L------------EMRISEGHFCDVYRAQIG--------SE--K----VAVKLFKQTNMAS---WK--KLWDVFRKEMEIH--HM--YQHPNILDLLCCFT----DAGRYCLVYPYLADG T_guttata_ENSTGUP00000011997 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS O_anatinus_ENSOANP00000021129 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS G_gallus_ENSGALP00000020950 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS B_taurus_ENSBTAP00000029006 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS E_caballus_ENSECAP00000003689 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS X_tropicalis_ENSXETP00000003054 S------------SKIIHEGEFADVYMGHKQ--------DK--L----YAIKRLKKVQDEE---QK--RMSSFFHTEAQIS--FR--CCHANILPLLGFCV----EGDCSCLINQFIRNG H_sapiens_ENSP00000288602 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS P_troglodytes_ENSPTRP00000033866 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS C_familiaris_ENSCAFP00000005841 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS P_pygmaeus_ENSPPYP00000020265 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS M_musculus_ENSMUSP00000002487 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS R_norvegicus_ENSRNOP00000014604 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS A_carolinensis_ENSACAP00000011088 -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS T_nigroviridis_ENSTNIP00000000196 -------------QKRIGTGSFGTVFKGKWH---------GD------VAVKILKVTEPTP-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS T_rubripes_ENSTRUP00000004441 -------------QKRIGTGSFGTVFKGKWH---------GD------VAVKILKVTEPTP-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS D_melanogaster_FBpp0079568 -------------LEELGEGAFGKVYKGQLL---------QPNKTTITVAIKALKENA-SV-------KTQQDFKREIELI--SD--LKHQNIVCILGVVL----NKEPYCMLFEYMANG O_latipes_ENSORLP00000020929 -------------QKRIGTGSFGTVYKGKWH---------GD------VAIKILKVKEPTP-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS O_cuniculus_ENSOCUP00000012185 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS G_aculeatus_ENSGACP00000000078 -------------SSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----E-DNLAIVTQWCEGS A_carolinensis_ENSACAP00000011023 -------------QKRIGTGSFGTVFKGRWY---------GD------VAIKILKVTNPTS-------EQVQAFKNEMQVL--RK--TRHVNILLFMGFMT----H-PSFAIITQWCDGS R_norvegicus_ENSRNOP00000013831 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS H_sapiens_ENSP00000251849 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS M_mulatta_ENSMMUP00000009777 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS P_pygmaeus_ENSPPYP00000014975 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS E_caballus_ENSECAP00000010011 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS M_musculus_ENSMUSP00000108571 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS C_familiaris_ENSCAFP00000007376 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS O_latipes_ENSORLP00000012350 -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTDPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS B_taurus_ENSBTAP00000005930 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQCQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS M_domestica_ENSMODP00000007826 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVIDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS G_gallus_ENSGALP00000007991 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS D_rerio_ENSDARP00000048390 -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS M_domestica_ENSMODP00000011339 K------------DLLIGEGEFFKVFRVELQ--------NG--T----YAVKLFKQETTIQ---NK--KNWKMFFSELEVL--NLKSTHHPLYRETSYYHI----SVPSFCSLFQLPPQI G_aculeatus_ENSGACP00000004834 -------------QKRIGAGSFGTVFKGKWH---------GD------VAIKILKVTEPTP-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS A_carolinensis_ENSACAP00000013056 -------------STRVGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS T_nigroviridis_ENSTNIP00000010036 -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS T_rubripes_ENSTRUP00000029372 -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS D_rerio_ENSDARP00000044241 -------------LSRIGSGSFGTVHKGKWH---------GD------VAVKVLKVTNPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-GNLAIVTQWCEGS P_troglodytes_ENSPTRP00000025252 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVNPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS T_rubripes_ENSTRUP00000016249 -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTNPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS G_aculeatus_ENSGACP00000025456 -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS T_nigroviridis_ENSTNIP00000015593 -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTNPTP-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS T_rubripes_ENSTRUP00000004702 -------------VKKLGAGQFGEVWMAYYN---------NTTK----VAVKTLKPG--TM--------TVEAFLDEANLM--KK--LQHDRLVRLYAVVT----KTEPIYIITEFMANG A_gambiae_AGAP011710-PA -------------GELLGKGFFGQVFKVTHR--------VTQEV----MVLKELYRVDE---------EAQKNFLKEVAVL--RS--LSHHNVLRFIGVLY----KDKKLHLVTEFIPGG O_latipes_ENSORLP00000014365 -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTDPTP-------EQLQAFRNEVAVLRCRK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS D_rerio_ENSDARP00000008826 -------------VKKLGAGQFGEVWMGFYK---------NNQK----VAIKTLKEG--TM--------EPEAFLQEANLM--KQ--LQHERLVKLHAVVT----R-EPIYIVTEYMANG E_caballus_ENSECAP00000003552 -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPTS-------EHFQAFRNKVAVL--HK--TRHVNVLLFMGYMT----K-DNLAIVTQWCEGS D_rerio_ENSDARP00000071167 -------------LKRIGAGSFGTVFKGKWH---------GD------VAIKILKVTEPTP-------EQLQAFKNEMQVL--RK--TRHVNILLFMGFMT----R-PNFAIITQWCEGS C_familiaris_ENSCAFP00000011788 -------------VRKLGSGQFGEVWMGYYK---------NNVK----VAIKTLKEG--TM--------SPEAFLGEANLM--KT--LQHERLVRLYAVVT----K-EPIYIVTEYMARG O_latipes_ENSORLP00000015921 -------------VKKLGAGQFGEVWMAYYN---------NTTK----VAVKTLKPG--TM--------TVEAFLEEANIM--KT--LQHERLVRLYAVVT----KTEPIYIITEYMANG O_anatinus_ENSOANP00000008740 -------------VKKLGAGQFGEVWMGYYN---------NTTK----VAVKTLKPG--TM--------SVQAFLEEANLM--KT--LQHDKLVRLYAVVT----KEEPIYIITEYMAKG O_latipes_ENSORLP00000021561 K------------REPLDYGGFGEVYLCYHA---------TLGQ----VVLKTLYTGPLRS------EESKRSLLEEGSIM--AS--LNHERVVKLLGVVM----EDRDCSLVLELLPRG M_domestica_ENSMODP00000011408 -------------VKKLGAGQFGEVWMGYYN---------GSTK----VAVKTLKPG--TM--------SVQSFIEEANLM--KT--LQHEKLVRLYAVVT----KEEPIYIVTEFMAKG A_gambiae_AGAP006219-PA -------------VEELGEGAFGKVYKGELT---------QKNGERIFVAVKALKENA-SA-------KTQADFKREIELI--SD--LKHDNIVCILGVVL----KEEPLCMLFEYMAQG G_aculeatus_ENSGACP00000018983 -------------VRKLGAGQFGDVWMAYYN---------NTTI----VAVKTLKPG--TM--------TAEAFMEEANVM--KT--LQHDRLVRLYAVVT----KTPPIYIITEYMANG C_familiaris_ENSCAFP00000015667 -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--SM--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG B_taurus_ENSBTAP00000037887 -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--SM--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG M_musculus_ENSMUSP00000100967 -------------GAQIGEGEFGAVLQGEYL--------GQ--K----VAVKNIKCD-----------VTAQAFLDETAVM--TK--LQHRNLVRLLGVIL----H-HGLYIVMEHVSKG R_norvegicus_ENSRNOP00000027730 -------------GAQIGEGEFGAVLQGEYL--------GQ--K----VAVKNIKCD-----------VTAQAFLDETAVM--TK--LQHRNLVRLLGVIL----H-HGLYIVMEHVSKG C_elegans_F33E2.2a -------------LEWLGSGSQGAVFRGQLE--------NR--T----VAVKKVNQLK----------------ETEIKHL--RH--LRHQNIIEFLGVCS----KSPCYCIVMEYCSKG C_intestinalis_ENSCINP00000023589 -------------HECCGEGTFGSVYRAIWV-------TQGKQE----VAVKKLN-----------------QMEKEAHVL--SV--LSHRNVIQFYGACV----DAPNFCIVTEYAPYG A_aegypti_AAEL000187-PA -------------GELLGKGFFGQVFKVTHR--------VTQEV----MVLKELYRVDE---------EAQKNFLKEVAVL--RS--LSHNNVLRFIGVLY----KDKKLHLVTEYIPGG X_tropicalis_ENSXETP00000010512 G------------GSHLGGHWAGTGQKAKWH--------FWD------VAVKMLNVTAPTP-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLRLVTQWCEGS P_pygmaeus_ENSPPYP00000020565 -------------VRKLGSGQFGEVWMGYYK---------NNMK----VAVKTLKEG--TM--------SPEAFLGEANVM--KA--LQHERLVRLYAVVT----K-EPIYIVTEYMARG D_rerio_ENSDARP00000095291 -------------LSRIGSGSFGTVYKGKWH---------GD------VAVKILKVINPTP-------EQLQAFRNEVAVL--RK--TRHVNIVLFMGYMT----K-VKLAIVTQWCEGS T_rubripes_ENSTRUP00000007128 -------------EIKLGQGCFGEVWMGTWN---------GTTK----VAIKTLKTG--TM--------SPEAFLQEAQIM--KK--LRHDKLVPLYAVVS----E-EPIYIVTEYMAKG O_latipes_ENSORLP00000020461 -------------LQWLGSGAQGAVFLGKFR--------SE--E----VAIKKVREQK----------------ETDIKHL--RK--LKHPNIISFKGVCT----QAPCYCIIMEYCAQG O_latipes_ENSORLP00000021875 -------------LRRLGAGQFGEVWMGLYN---------NDSK----VAIKNLKMG--TM--------SVEAFLAEANMM--KN--LQHPRLVRLFAVVT----E-EPIYIVTEYMENG C_intestinalis_ENSCINP00000011940 -------------GKKLGSGQFGEVHKGLWN---------KTTT----VAVKTMKSSD-SL--------NKEEFLKEARLM--KK--LHHPKLVQLFAVCT----QSEPFYIVTELMCNG H_sapiens_ENSP00000259089 -------------VRKLGSGQFGEVWMGYYK---------NNMK----VAIKTLKEG--TM--------SPEAFLGEANVM--KA--LQHERLVRLYAVVT----K-EPIYIVTEYMARG A_aegypti_AAEL004592-PA -------------IRKLGHGNFGEVYYGKWR---------NNIE----VAVKTLREG--TM--------STQAFLQEAAIM--KK--FRHSRLVALYAVCS----KEEPIYIVQEYMSKG T_rubripes_ENSTRUP00000008303 -------------IKRLGNGQFGEVWMGTWN---------GTTK----VAVKTLKPG--TM--------SPESFLEEAQIM--KK--LRHDKLVQLYAVVS----E-EPIYIVTEYMGKG X_tropicalis_ENSXETP00000003560 -------------LQQVGRGGFGTVYRGWSR--------SLNME----VALKTFQRAQS---------------QNEREVM--EK--ASNPFVILLLGMYERQEGEVSEHGLVMEYVPNG X_tropicalis_ENSXETP00000046976 -------------LEVKARGRFGCVWKAQLL--------NE--T----VAVKIFPIQDKLS----------WQNEYEIYNL--PG--MKHENILQFIGAEKRGTNLDTDLWLITAFHEKG T_nigroviridis_ENSTNIP00000019431 -------------VKKLGAGQFGEVWMGYYK---------NTQK----VAIKTLKEG--TM--------EPAAFLEEANLM--KQ--LQHERLVRLHAVVT----K-EPILIVTEFMVNG T_rubripes_ENSTRUP00000004157 -------------LEVKGRGRFGCVWKAQLL--------SD--V----VAVKIFPLQDKQS----------WQNEYEIFTL--NG--MGHENVLQFIGAERRGSHVDMELWLITAYHEKG P_pygmaeus_ENSPPYP00000001840 -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--SM--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG E_caballus_ENSECAP00000020913 -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--SM--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG T_rubripes_ENSTRUP00000030627 -------------LQWLGSGAQGAVFLGKFR--------SE--E----VAIKKVREQK----------------ETEIKHL--RK--LKHPNIISFKGVCT----QAPCYCIIMEYCAQG T_nigroviridis_ENSTNIP00000020756 -------------VKRLGAGQFGEVWMAYYN---------NITR----VAVKTLKPG--TM--------TVEAFMDEANLM--KK--LQHDRLVRLYAVVT----KTEPIYIITEYMANG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDIKSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI P_troglodytes_ENSPTRP00000008285 SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDIKSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI M_mulatta_ENSMMUP00000000286 SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDIKSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI E_caballus_ENSECAP00000012782 SLLDRL-SCLD-----DTPPLSWHMRCKIAHGAANGISFLH--------E--NHHIHRDIKSANILLDEAFTAKISDFGLARASER--------FTQ-------------TVM---TSRI C_familiaris_ENSCAFP00000014260 SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGISFLH--------E--NHHIHRDIKSANILLDEDFTAKVSDFGLARASEK--------FAQ-------------TVM---TSRI P_pygmaeus_ENSPPYP00000005053 SLLDRL-SCLD-----GTPPLSWHMRCKIAQDAANGINFLH--------E--NHHIHRDIKSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI B_taurus_ENSBTAP00000028115 SLLDRL-SCLD-----GTPPLSWNMRCKIAQGAANGLSYLH--------E--NHHIHRDIKSANILLDEDFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI R_norvegicus_ENSRNOP00000007932 SLLDRL-SCLD-----GTPPLSWHMRCKIARGAANGIRFLH--------E--NHHIHRDIKSANILLDQDFTAKISDFGLARASAK--------LAQ-------------TVM---TSRI M_musculus_ENSMUSP00000074471 SLLDRL-SCLD-----GTPPLSWHTRCKVAQGTANGIRFLH--------E--NHHIHRDIKSANILLDKDFTAKISDFGLARASAR--------LAQ-------------TVM---TSRI M_domestica_ENSMODP00000023115 SLLDRL-SCLD-----GTEPLSWQTRCKIAQGTANGIYYLH--------A--NNHVHRDIKSANILLDEDFLPKISDFGLARTSAK--------FNQ-------------TVM---TSRI G_gallus_ENSGALP00000015600 SLLDRL-ACLD-----GTPPISWNTRCEIAQGTANGINFLH--------D--NNHIHRDIKSANILLTDTYVPKISDFGLARASVT--------FTR-------------TIM---TDRV T_guttata_ENSTGUP00000006104 SLLDRL-ACLD-----ETPPIPWNMRCKIVQGTANGINFLH--------E--NNHIHRDIKSANILLTDTYVPKISDFGLARASVT--------FTQ-------------TIM---TERI A_carolinensis_ENSACAP00000002933 SLLDRL-ACLD-----DTPPIPWKTRCNIAQGASNGICFLH--------E--NNHIHRDVKSANILLTEKFVPKLSDFGLARASVK--------FTH-------------TIL---TERI T_nigroviridis_ENSTNIP00000019071 SLLNCL-ACLE-----GSPPLSWKQRCSIAEGTANGLDYLH----------SNHHVHRDVKSANILLDEKRVAKISDFGLTRASPK--------GTS------------TTMM---TERI O_latipes_ENSORLP00000003907 SLLDRL-ACLD-----GSPPLSWQLRCFISEGAARGLEYLH----------SNHHVHRDVKSANILLDENYVAKISDFGLTRASAN--------RTS------------TTMM---TERI G_aculeatus_ENSGACP00000005326 SLLDRL-ACLE-----GSPPLSWRQRSLIAEGTARGLEYLH----------GNHHVHRDVKSANILLDENLVAKISDFGLTRASAK--------RTS------------TTMM---TERI T_rubripes_ENSTRUP00000042842 SLLDRL-ACLE-----GTPPLSWKQRCLIAEGTASGLEFVH--------R--NHHVHRDVKSANILLDEKLVAKISDFGLTRASPK--------GTS------------TTMK---TERI O_cuniculus_ENSOCUP00000003553 XXXXXX-XXXD-----DTAPLSWHTRCNIAQGAAAGISFLH--------E--NHHIHRDIKXXXXXXXXXXXXXXXXXXXXXXXXX--------XXX-------------XXX---XXXX O_anatinus_ENSOANP00000003026 SLFDRL-SCLV-----SSP----------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000015329 SLSSSLESCRL-----GKVVLLVGQRLEIAKGSSNGISYLH----------EQKLIHRDIKSSNILLDSNMKPRISDFGLIRSTST--------KTVD----------LTSTK---TTNP X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 SLQNKL-QCHD-----DSAPLTWEMRISISLGVVRAVEYLH----------NFGILHGNIKSSNVLLDENFTPKLGHSGL----RL--HS--SDKKSE----------YAMMK---TKVL H_sapiens_ENSP00000358997 SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV P_pygmaeus_ENSPPYP00000023353 SLEDRL-HCRT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV B_taurus_ENSBTAP00000021407 SLEDRL-HVQT----QAWPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDVKSSNVLLDERLMPKLGDFGLARLSRF--TG--ANPGQS----------SSVAR---TRTV C_elegans_K09B11.1 SLEDRL-LCRK-----GSVPLTWIQRKEISIGAGRGLGFLH-------SFGKTPIIHGDIKTANILLDKHMEPKIGDFGLCRDGHV------EAEAME----------KHPLI---ASHI C_familiaris_ENSCAFP00000000535 SLSDRL-QCVG-----NTAPLSWHIRISVLLGTARAIQYLH--N-----TEPCSVICGSVSSANILLDDQFQPKLTDFGMAHFRPH-------LEHQS----------CTISV---ASSS D_rerio_ENSDARP00000092301 SLDDRL-RNEV----ICINALSWSQRVNVLLGTAKAIQYLH--------SCSPALIHGDIKSSNILLGDHLEPKLGDFGLARLCRN--PN--KTPGKT----------STVAQ---TATV G_gorilla_ENSGGOP00000000218 SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV E_caballus_ENSECAP00000007763 SLEDRL-HFQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARLSRF--AG--ANPSQS----------STVAR---TRTV M_mulatta_ENSMMUP00000026705 SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------STVAR---TRTV O_anatinus_ENSOANP00000017468 SLEDRL-HGQR----RSLAPLSWAQRVDILVGTARAIQFLH--------RDNPSLIHGDVKSSNILLDEKLTPKLGDFGLARFSRF--TG--ASSGRS----------SSLAR---TQTV X_tropicalis_ENSXETP00000031192 SLEDRL-HPQG----RF-PKLPMEQRISILQGAACGLQYLH--------NYQPSIIHGDVKSSNILLDQAFMPKLGDFGLARFSRY--T---SNAGNS----------RTLAR---TSTV R_norvegicus_ENSRNOP00000005686 TLFDRL-QCTN-----GTTPLSWHVRISVLIGIAKAIQCLH--N-----TRPCAVICGNISSANILLDDQFQPKLTDFAAAHFRPH-------LEQQS----------STINM---TGSG M_musculus_ENSMUSP00000033769 SLEDQL-HLQT----QACSPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRF--AG--AKASQS----------STVAR---TSTV G_aculeatus_ENSGACP00000001480 SLEDQL-QHKQCVCPQECVSLTWSQRVGVVKGASAALQFLHFPP-----DGHAALIHGDVKSSNILLDRHLVAKLADFGLARLAHRRPAG--RSAGQT----------ASVGK---TATV A_carolinensis_ENSACAP00000012253 SLDDHL-HRQV------GPCLTWSQRLHVAVGTSRAIQFLH--------SDSPSLIHGDVKSSNILLDAALNPRLADFGLARFSRR-----PKQGTMS----------SSLGR---TQTV M_domestica_ENSMODP00000037830 SLEDQL-HSQN----QNPSLLSWAQRVDILLGTARAIQFLH--------QDNPSLIHGDVKSSNILLDEKLVPKLGDFGLARFSRY--SG--AASGKS----------SSLAR---TQTV R_norvegicus_ENSRNOP00000053167 SLEDQL-HLQT----QACSPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRF--AG--ANPSQS----------STVAR---TCTV M_musculus_ENSMUSP00000020448 TLFDRL-QCTN-----GTTPLSWHVRISVLIGIAKAIQYLH--N-----TQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPN-------LEQQS----------STINM---TGGG B_taurus_ENSBTAP00000033611 SLFDRL-QCVG-----DTAPLSWHIRIGVLIGTSKAIQYLH--N-----TELCSVICGSISSANILLDDQFQPKLTDFAMAHFRPH-------LEPQS----------SAISM---TSSS A_gambiae_AGAP002966-PA SLDKSL-FARR-----PASPLTWRERMNIAIGTARGLQYLH-------TFGDKPFIHGDIKPGNILLNEYKQPRIGDFGLTRQGAV--------QDSA----------TV------VSRV C_familiaris_ENSCAFP00000028744 SLEDRL-HFQT----EACAPLSWPQRLNILLGTARAIQFLH--------QDSPSLIHGDIKSSNVLLDDRLMPKLGDFGLARLSRF--AG--ANPGQS----------STVAR---TRTV P_troglodytes_ENSPTRP00000008814 TLFDRL-QCVG-----DTAPLPWHIRISILIGISKAIHYLH--N-----VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS H_sapiens_ENSP00000261233 TLFDRL-QCVG-----DTAPLPWHIRIGILIGISKAIHYLH--N-----VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS M_mulatta_ENSMMUP00000021862 TLFDRL-QCVG-----DTAPLPWHVRISILIGISKAIHYLH--N-----VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSH-------VEHQS----------CTINM---TSSS T_rubripes_ENSTRUP00000016336 SLEHKL-HNGD----QQSSYLSWSQRVSVVTEASTALQFLHSPP-----SGNTPLIHGDVKSSNILLDHHMTAKLGDFGLARFAPR------PSPSET----------KPLGR---TTTI A_gambiae_AGAP003062-PA NLEAALSLVRA-----GQRQMGATVRLQYLKDIANAVAFLH---------ERAKIIHRDVKSANILLDGP-VAKLCDFGLIKRTSS--------RT--------------------TTSI P_pygmaeus_ENSPPYP00000005399 TLFDRL-QCVG-----DTAPLPWHIRISILIGISKAIHYLH--N-----VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS O_anatinus_ENSOANP00000009429 SLFDRL-QCLG-----NTAPLSWKVRLGVLIGVARAIQVLH--S-----AKPCSVISGSITSTNILLDDQFQPKLTDFATVHLQPQ-------TDCRS----------FTVST---KSNA G_gallus_ENSGALP00000035437 SLQNKL-QHQD-----DSAPLPWEIRLSISVGLIRAVEYLH----------NFGILHGNIKSSNVLLDENFTPKLGHSGL----RL--YS--ADKKSE----------CTMMK---TKVM P_troglodytes_ENSPTRP00000038647 SLEDRL-HCQ----------------------TARAIQFLH--------QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV P_pygmaeus_ENSPPYP00000015274 SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNVKSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLF E_caballus_ENSECAP00000010808 SLQDRL-QHQG-----GSDPLLWLQRVSICSGLLRAVEHLH----------GLDIIHSNIKSSNVLLDENFTPKLAHPMA----HL--CP--VNKRSR----------YTVMK---THLF T_nigroviridis_ENSTNIP00000007783 SLEHKL-HNAR----QQGSCLSWSQRVGVVTGASTALQFLHCPP-----KGNAPLIHGDVKSSNILLDQHMTAKLGDFGLASLALK-----SSSPSAT----------TTLGC---TTTI D_rerio_ENSDARP00000067130 SLFHRL-HEH------VDKPLSWQERLNIIKGTAKAVHHLH-------TSQPCTVICGNITSSNILLDENMQPKLCDFGLARLRPH-------SVDQS----------CTIVM---NTAL P_troglodytes_ENSPTRP00000025212 SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNVKSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLL H_sapiens_ENSP00000256458 SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNVKSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLL D_melanogaster_FBpp0084549 SLEARL-RAHK--AQNPLPALTWQQRFSISLGTARGIYFLH-------TARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPK----------SL----------DAVVE---VNKV C_familiaris_ENSCAFP00000007680 SLQDRL-QDQD-----GSEPLLWPQRASICSGLLRAVEHLH----------GLGIIHGNVKSSNVLLDQNFIPKLAHPIA----HL--CS--DNKRSK----------YTMMK---THLF M_mulatta_ENSMMUP00000026192 SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNVKSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTVMK---THLF M_domestica_ENSMODP00000033729 SLEDRL-RCQD-----NTDPLSWEQRISISLGFLGAIEYLH----------GLKIIHGNIKSSNVLLERNFIPKLGHPRV----RV--SS--NDKKSS----------YTMMN---TQLF A_aegypti_AAEL007642-PA TLGAALDKSRK-----GQLHLTVTRRISYLFGIAAALEYLH--------SPLVQVVHRDVTLANILLHGD-VAKLCDFGLVKRIDS--------IT--------------------ATEV T_guttata_ENSTGUP00000014323 SLQNKL-QCHD-----DSAPLTWEMRISISLGVVRAVDYLH----------NFGILHGNIKSSNVLLDENFTPKLGHSGL----RL--HS--SDKKSE----------YAMMK---TKVL B_taurus_ENSBTAP00000008135 SLQDRL-QGQG-----GSDPLPWPQRISICSGLLHAVEHLH----------SLEIIHGNVKSSNVLLDQNFTPKLAHSMA----HP--CP--VNRTSK----------YTMMK---THLF M_musculus_ENSMUSP00000055073 SLHDRL-WAQG-----NSDMLPWPQRASICSGLLLAVEHLH----------SLDIIHSNVKSANVLLDQHLNPKLAHPVA----HP--HP--DNKKTK----------YTVMR---THLF A_carolinensis_ENSACAP00000014667 SLMDRL-QCQG-----GSESLTWTQRIKISLGLIQAIQHLH----------RFGILHGNVKSSNVLLDADFVPQLGHSGL----RL--HP--IEKKTD----------RAMMK---TKVL G_gorilla_ENSGGOP00000006760 TLFDRL-QCVG-----DTAPLPWHIRISILIEISKAIHYLH--N-----VQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS G_aculeatus_ENSGACP00000025500 SLFHRL-HHQ------DREPLSWQQRLTIIKGTAKALHHLH-------TAQPCPVICGSISSANILLGSNLQPKLSSFGIARLRPH-------SANQN----------STVTL---DTRS T_guttata_ENSTGUP00000011997 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------QQ------FEQL O_anatinus_ENSOANP00000021129 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL G_gallus_ENSGALP00000020950 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL B_taurus_ENSBTAP00000029006 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL E_caballus_ENSECAP00000003689 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL X_tropicalis_ENSXETP00000003054 SLDLAL-Q-QS-----GNHILNWERRLKIALGFLKAIRHLH----------SNDILHGNIKSSNIFLDENSFPKLGHSGL----RF--CP---DKQAG----------YTKAK---SKDL H_sapiens_ENSP00000288602 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL P_troglodytes_ENSPTRP00000033866 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL C_familiaris_ENSCAFP00000005841 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL P_pygmaeus_ENSPPYP00000020265 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL M_musculus_ENSMUSP00000002487 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL R_norvegicus_ENSRNOP00000014604 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL A_carolinensis_ENSACAP00000011088 SLYHHL-HII-------ETKFEMIKLIDVARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL T_nigroviridis_ENSTNIP00000000196 SLYRHL-HVT-------ETKFDTMRRIDVARQTSQGMDYLH----------AKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------KQ------VEQP T_rubripes_ENSTRUP00000004441 SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------KQ------VEQP D_melanogaster_FBpp0079568 DLHEFL-ISNS---PTEGKSLSQLEFLQIALQISEGMQYLS----------AHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYS--------SDYY----------RV------QSKS O_latipes_ENSORLP00000020929 SLYRHL-HVS-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKAR--------WSGS----------QQ------VEQP O_cuniculus_ENSOCUP00000012185 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP G_aculeatus_ENSGACP00000000078 SLYKHL-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HQ------VEQP A_carolinensis_ENSACAP00000011023 SLYQHL-HVQ-------ETPLEMVQRIDVARQTAQGMDYLH----------AKHIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTR--------WSGA----------QQ------VEQP R_norvegicus_ENSRNOP00000013831 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP H_sapiens_ENSP00000251849 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP M_mulatta_ENSMMUP00000009777 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP P_pygmaeus_ENSPPYP00000014975 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP E_caballus_ENSECAP00000010011 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP M_musculus_ENSMUSP00000108571 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP C_familiaris_ENSCAFP00000007376 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP O_latipes_ENSORLP00000012350 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL B_taurus_ENSBTAP00000005930 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP M_domestica_ENSMODP00000007826 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP G_gallus_ENSGALP00000007991 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP D_rerio_ENSDARP00000048390 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL M_domestica_ENSMODP00000011339 SLYKKL-ENVG---DDNTFPLSWQLRLSILIGAAKAIQYLH--H-----VEPCSVICGNITSSNILLDSQFQPKLTNFVTAHLRPH-------LEKQS----------STINM---ESSR G_aculeatus_ENSGACP00000004834 SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP A_carolinensis_ENSACAP00000013056 SLYKHL-HVQ-------ETKFQMLQRIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEDRTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP T_nigroviridis_ENSTNIP00000010036 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL T_rubripes_ENSTRUP00000029372 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL D_rerio_ENSDARP00000044241 SLYKHL-HVL-------ETNFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------QQ------VEQP P_troglodytes_ENSPTRP00000025252 SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP T_rubripes_ENSTRUP00000016249 SLYKHI-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------NQ------VEQP G_aculeatus_ENSGACP00000025456 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL T_nigroviridis_ENSTNIP00000015593 SLYKHI-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------HQ------VEQP T_rubripes_ENSTRUP00000004702 SLLDFL-KSD------SGCTLPMPKLIDFSAQIAEGMAYIE----------KKNYIHRDLRAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA A_gambiae_AGAP011710-PA SLKELI-HD-------SGLPLSWAQRISFARDISSGMSYLH----------SMNIIHRDLNSLNCLVRENGTVIVADFGLARIIKQPLIST---TAYE----------KPRRQ---RYTV O_latipes_ENSORLP00000014365 SLYKHI-HVL-------ETNFKMIQLIDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HQ------VEQP D_rerio_ENSDARP00000008826 SLLDFL-KTD------DGHKLKLSKLIDMTAQIAEGMAYIE----------RKNYIHRDLRAANILVSETLHCKIADFGLARIIE---------TE-Y----------TA------QEGA E_caballus_ENSECAP00000003552 SLYKHL-HVQ-------ETKFQMFQLIDITRQTAQGMDYLH----------AKNIIHRDMKSKNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP D_rerio_ENSDARP00000071167 SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------RSNSP---VAPS C_familiaris_ENSCAFP00000011788 CLLDFL-KTV------EGSRLSLPRLIDMSAQIAEGMAYIE----------QMNSIHRDLRAANILVSETLCCKIADFGLARII-D--------SE-Y----------TA------QEGA O_latipes_ENSORLP00000015921 SLLDFL-KSE------VGGKLQLPKLIDFSAQIAEGMSFIE----------KRNYIHRDLRAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA O_anatinus_ENSOANP00000008740 SLLDFL-KSD------EGGKVLLPKLIDFSAQIAEGMAYIE----------RKNYIHRDLRAANVLVSEALKCKIADFGLARIIED--------NE-Y----------TA------REGA O_latipes_ENSORLP00000021561 NLLVML-ETVK---------VPISIKGRIILEVLEGMIYLT----------EKRVIHKDIKPENILVDKDFHIKIADLGLATCQTWSKLT--KEESRR----------KSRSGQTSGARG M_domestica_ENSMODP00000011408 SLLDFL-KSG------EGTKLLLPKLIDFSAQIAEGMAFLE----------RKNYIHRDLRAANVLVSESLICKIADFGLARIIRD--------DE-Y----------KA------REGA A_gambiae_AGAP006219-PA DLHEFL-IANS---PNEGKSLSQLQFLLIAQQICDGMEYLA----------SHHYVHRDLAARNCLVGDNLTVKISDFGLSRDIYS--------SDYY----------RV------QSKS G_aculeatus_ENSGACP00000018983 SLLDFL-KSD------AGCRLQLPKLIDFSAQIAEGMAFIE----------RKNYIHRDLRAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA C_familiaris_ENSCAFP00000015667 SLVDFL-KTP------PGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDLRAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA B_taurus_ENSBTAP00000037887 SLVDFL-KTS------EGIKLTINKLLDMAAQIAEGMAFIE----------EQNYIHRDLRAANILVSHSLSCKIADFGLARLIED--------NE-Y----------TA------REGA M_musculus_ENSMUSP00000100967 NLVNFL-RTR------GRALVSTSQLLQFALHVAEGMEYLE----------SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAER-----------------------KG------LDSS R_norvegicus_ENSRNOP00000027730 NLVNFL-RTR------GRALVSTSQLLQFALHVAEGMEYLE----------SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAELR----------------------KG------LDSS C_elegans_F33E2.2a QLCTVL-KSRN--------TITRELFAQWVKEIADGMHYLH----------QNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKK--------MDST------------------MMSF C_intestinalis_ENSCINP00000023589 SLFDFL-ATK------ESEKLEFSQLLSWSRDIGLGMNYLH-------EEAPVAVIHRDLKSKNVVICSDFTLKICDFGASRFFGETI----------------------------VMTI A_aegypti_AAEL000187-PA SLKELI-HD-------SGLPLPWELRIRFARDISCGMSYLH----------SMNIIHRDLNSLNCLVREDKTVIVADFGLARIIKQPFSTAFEKCSQSNGTGTVGRRGRPRRQ---RYTV X_tropicalis_ENSXETP00000010512 SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL P_pygmaeus_ENSPPYP00000020565 CLLDFL-KTD------EGSRLSLPRLIDMSAQIAEGMAYIE----------RMNSIHRDLRAANILVSEALCCKIADFGLARII-D--------SE-Y----------TA------QEGA D_rerio_ENSDARP00000095291 SLYKHL-HVQ-------ETNFQMFQLMDIARQTAQGMDYLH----------AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HR------VEQP T_rubripes_ENSTRUP00000007128 SLLDFL-KEG------DGKFLKLPLLVDMAAQIADGMAFIE----------RMNYIHRDLRAANILVGDNLVCKIADFGLARLIED--------NE-Y----------TA------RQGA O_latipes_ENSORLP00000020461 QLYEVL-RAGR--------KVTPRLLVDWATGIASGMNYLH----------LHKIIHRDLKSPNVLVTQADTVKISDFGTSKELSD--------KST-------------------KMSF O_latipes_ENSORLP00000021875 SLVDFL-KTQ------EGGNLPINTLIDMASQVADGMAFIE----------QRNYIHRDLRAANILVSHELICKVADFGLARLIED--------NE-Y----------TA------REGA C_intestinalis_ENSCINP00000011940 ALLDYL-R--------EDLNLEEEVLIDMATQVATGMAYLE----------VKNYIHRDLAARNILVGKNNNCKVADFGLARLTQD--------DEIY----------QA------KVKA H_sapiens_ENSP00000259089 CLLDFL-KTD------EGSRLSLPRLIDMSAQIAEGMAYIE----------RMNSIHRDLRAANILVSEALCCKIADFGLARII-D--------SE-Y----------TA------QEGA A_aegypti_AAEL004592-PA SLLDYL-RTG------DGQFLQFEDLIYIAAQVASGMEYLE----------LKQLIHRDLAARNVLIGENNVAKICDFGLARVIAD--------DE-Y----------CP------KQGS T_rubripes_ENSTRUP00000008303 SLLDFL-KDG------EGRMLKLPNLVDMAAQVAAGMAYIE----------RMNYIHRDLRSANILVGDNLTCKIADFGLARLIED--------NE-Y----------TA------RQGA X_tropicalis_ENSXETP00000003560 SLRSLF-DTMD---------VPWALRFQMLHQVALGMNYLH--------TLDPPIIHRDLKPSNVLLNKHFDVKITDFGLSKIAGA--------TTSA------------------TPYF X_tropicalis_ENSXETP00000046976 SLTDYL-KANV---------VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEA--------GKSA----------GD------THGQ T_nigroviridis_ENSTNIP00000019431 SLLDFL-KSD------AGKKLKVNKLIDMAAQIAEGMAYIE----------VKNYIHRDLRAANILVSETLHCKIADFGLARIIE---------SE-Y----------TA------QEGA T_rubripes_ENSTRUP00000004157 CLTDYL-KADV---------LSWSQVCVIAQSMSRGLAYLHEDVP----GHKPAIAHRDVKSKNVLLKSNLTACIADFGLALRFEA--------GRSP----------GE------THRQ P_pygmaeus_ENSPPYP00000001840 SLVDFL-KTP------SGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDLRAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA E_caballus_ENSECAP00000020913 SLVDFL-KTS------TGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDLRAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA T_rubripes_ENSTRUP00000030627 QLYEVL-RAGR--------KVTPRMLVDWASGIASGMNYLH----------LHKIIHRDLKSPNVLVTHNDTVKISDFGTSKELSD--------KST-------------------KMSF T_nigroviridis_ENSTNIP00000020756 SLLDFL-KSD------LGCSLQIPKLIDFSAQIAEGMAYIE----------RRNYIHRDLRAANVLVSECLLCKIADFGLARVIED--------DE-Y----------SA------REGA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- P_troglodytes_ENSPTRP00000008285 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- M_mulatta_ENSMMUP00000000286 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- E_caballus_ENSECAP00000012782 MGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKDEI---EDEEKT-------------------------------IEDYIDK- C_familiaris_ENSCAFP00000014260 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDP- P_pygmaeus_ENSPPYP00000005053 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- B_taurus_ENSBTAP00000028115 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYVDR- R_norvegicus_ENSRNOP00000007932 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLELIT-GL-AAVDENR----EP-QLLLDIKEEI---EDKEKT-------------------------------IEDCTDE- M_musculus_ENSMUSP00000074471 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLELIT-GL-AAVDENR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYTDE- M_domestica_ENSMODP00000023115 VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEQR----EP-QLLLDIKEEI---EDEEKH-------------------------------IEDYIDA- G_gallus_ENSGALP00000015600 VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEVIT-GL-PPVDENR----EP-QLLLSIKDEI---EDEEAT-------------------------------IEDYVDV- T_guttata_ENSTGUP00000006104 VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEIIT-GL-PPVDENR----EP-QLLLTIKDEI---EDEEAT-------------------------------IEDYVDV- A_carolinensis_ENSACAP00000002933 VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEIIT-GL-PPVDENR----DP-QLLLTIKEEI---EDEEKT-------------------------------LEDYIDE- T_nigroviridis_ENSTNIP00000019071 VGTCAYMAPEALR----GQVT------PKSDIFSFGVVLLEILS-GL-PPADENR----EP-QFLMEVTFTI-DDEDEELT-------------------------------LEGFLDK- O_latipes_ENSORLP00000003907 VGTRAYMAPEALR----GEVT------PKSDVFSFGVVLLEILS-GL-PPADEKQ----EP-QFLMEFRYDI-DDEDEELT-------------------------------LEDFVDK- G_aculeatus_ENSGACP00000005326 VGTRAYMAPEALR----GEIT------PRSDVFSFGVVLLEILS-GQ-RPADEER----EP-QFLMEMRHDI-DDEDEELT-------------------------------FEDFLDK- T_rubripes_ENSTRUP00000042842 VGTCAYMAPEALR----GQVT------PKSDIFSFGVVLLEILS-GL-PPVDENH----NP-QFLMEVPSAI-EDEDEELT-------------------------------FEGFLDT- O_cuniculus_ENSOCUP00000003553 XXXXXXXXXXXXX----XXXX------XXXXXXXXXXVLLEIIT-GL-PAVDEHR----EP-QLLLDIKEEI---EDEEKT-------------------------------IEDYVDT- O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 IGTMVYMSPEAFK----GVVS------YSMDVYSFGVVLLELLT-GL-PVLDENR----DP-SHLPMFIEE------SMEE---------------------------DETSLSMFADT- X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 QASLTYLPEDFVRH---GQLT------EKVDIFSCGVVLAEILT-GI-KALDEDR----HP-IYLKDMIAD------EIQS-AKEGSNSKVKNL----------EKLAAKEICCKYLDR- H_sapiens_ENSP00000358997 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---ART-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAAPIAMQIYKKHLDP- P_pygmaeus_ENSPPYP00000023353 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---ART-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAVPIAMQIYKKHLDP- B_taurus_ENSBTAP00000021407 RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVLLETLA-GQ-RAVRMHG---AQP-KYLKDLVEE------EAEE-AGVTLKGTQTAVQGGP-AADTWAALVAAQIYKKHLDP- C_elegans_K09B11.1 KGTLAYLAPEFITS---KILT------TKLDVYSFGIVLLEIAS-GQ-RAYSDSR----ET-RGLVEYCQV-----------------------------NKELAAHRKIPVREIFIDRR C_familiaris_ENSCAFP00000000535 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-KVVLDDP----KH-IQLRDLLME------LMEK-------------------------RG-LDSCLSFLDK- D_rerio_ENSDARP00000092301 RGTLAYLPEEYLKD---GQLG------VEIDAYSFGVVMLEVLT-GR-QALEVDS--QSKT-VFLKDLVTE------EEDD-GRSFSKAKH--------SRDLSYGQTAEHICKKHLDR- G_gorilla_ENSGGOP00000000218 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLT-GQ-RAVKTHG---ART-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGV-AADAWAAPIAMQIYKKHLDP- E_caballus_ENSECAP00000007763 RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVVLESLV-GQ-RAVRTHG---ART-KYLKDLVEE------EAEE-AGVALKSTQTAIKAGL-ATDAWAAPIATQIYKKHLDP- M_mulatta_ENSMMUP00000026705 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-AQ-RAVKTHG---ARI-KYLKDLVEE------EAEE-AGVALRSTQSTL-----AADSWAAPIAMQICKKHLDP- O_anatinus_ENSOANP00000017468 RGTLAYLPEEYVKT---GKLT------VEIDTYSFGVVLLEILT-GR-RAMESAGDGRSRA-KYLKDLVEE------EDVE-ADEPQKRNWPSTSGDISASDVRAAAVATRLYRKHLDS- X_tropicalis_ENSXETP00000031192 KGTLAYLPEEYVKM---GKLT------FELDTYSFGVVLLENLT-GR-KAIESDS--KSHT-KYLKDLVKEEECKDEEEEE-KGASMAS----------GAEAKLARVAARICQYHLDF- R_norvegicus_ENSRNOP00000005686 RKHLWYMPEEYIRQ---GRLT------IKTDVYSFGIVIMEVLT-GC-KVVLDDP----KH-VQLRDLLME------LVEK-------------------------RG-LDSCLSFLDR- M_musculus_ENSMUSP00000033769 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVILETLA-GQ-RAVRTQG---AKT-KYLKDLIED------EAEE-AGVTLKSTQPTLWVGV-ATDAWAAPIAAQIYKKHLDS- G_aculeatus_ENSGACP00000001480 RGTLAYLPVEYVRN---GELG------TAVDVYSFGVVLLEVLT-GR-RALELGR--KSGE-TYLKDLVEE------VEENLTGSSAEA-----------------------WRKQLDH- A_carolinensis_ENSACAP00000012253 QGTLAYLPPEYVRT---GTLS------TAIDVFSFGV----------------------------KDLLSE------EEEA-QHTPTTMT---------SSSSQAAQLGTSLYQKHMDL- M_domestica_ENSMODP00000037830 RGTLAYLPEEYVKT---GKLT------VEIDTFSFGVVLLEILT-GC-RAIETDG---ART-KYLKDLVEE------EEEE-TLASCKGMATG--AGV-DLEARAAQIGSRLYAKYTDS- R_norvegicus_ENSRNOP00000053167 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVILETLA-GQ-RAVRTQG---AKT-KYLKDLIED------EAEE-VGVTLKSTQPTLWMGV-ATDAWTAPIAAQIYKKHLDS- M_musculus_ENSMUSP00000020448 RKHLWYMPEEYIRQ---GRLS------VKTDVYSFGIVIMEVLT-GC-KVVLDDP----KH-VQLRDLLME------LMEK-------------------------RG-LDSCLSFLDR- B_taurus_ENSBTAP00000033611 SKHVWYMPEEYIRQ---GKLS------IKTDIYSFGIVIMEVLT-GC-KVVLDEP----KH-IQLRDLLIE------LMEK-------------------------RG-LDSCISFLDK- A_gambiae_AGAP002966-PA YGTRPYIPKEFYDR---RELS------TKVDTYSFGVVLYEIGT-GL-RAWDERR----TE-KHLKDYIAR------AVQE----------------------------QMHVTQLADQ- C_familiaris_ENSCAFP00000028744 RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVRTQG---AKT-KYLKDLVEE------EAEE-AGVTLRSTQSTLQAGL-ATDAWAAPIASQICKKHLDP- P_troglodytes_ENSPTRP00000008814 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----KH-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- H_sapiens_ENSP00000261233 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----KH-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- M_mulatta_ENSMMUP00000021862 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----KH-IQLRDLLIE------LMEK-------------------------RG-LDSCLSFLDK- T_rubripes_ENSTRUP00000016336 RGTLAYLPHEYVRT---GKLG------TVVDVYSFGVVLLEVLT-GR-RALEEDQ--DLGQ-KYLKDLVEE------IRESPSGSPEESWRKQLDHRL-LAVTWSRSTAAVSA------- A_gambiae_AGAP003062-PA IGTNAYMAPEAVR----GDVS------PALDIFAFGIVVAETVT-GE-PVLAEKE---SRSEIDLAGYVCRQRAEGRD----------------------------------LGLLVDRR P_pygmaeus_ENSPPYP00000005399 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----KH-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- O_anatinus_ENSOANP00000009429 AKHLWYMPEEYLRQ---SRLS------TKTDVYSFGIIIMEVLT-GC-KVVMEEP----KH-IQLRDLLME------MMEK-------------------------RG-LDSCFSLLDK- G_gallus_ENSGALP00000035437 QASLTYLPEDFVRH---GQLT------EKVDVFGCGVVLAEILT-GI-KALDEGR----SP-IYLKDMIAD------EIQT-AKETSHSKDKNL----------EKLAAKEICCKYLDK- P_troglodytes_ENSPTRP00000038647 RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---ART-KYLKDLVEE------EAEE-AGVALRSTQSTLHAGL-AADAWAAPIAMQIYKKHLDP- P_pygmaeus_ENSPPYP00000015274 RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----SP-VYLKDLLLS------EIPS-STASPCSRKTGV----------ENVMAKEICQKYLEK- E_caballus_ENSECAP00000010808 QASAAYLPDDFIRV---GQLT------KRVDVFSCGIVLAEVLT-GI-PAMDNGR----SP-VYLKDLLLS------EIPS-STTSLCSRKTDV----------EKVMAKELCQKYLEK- T_nigroviridis_ENSTNIP00000007783 RGTLAYLPMEYVRK---GELG------TVVDVYSFGVVLLEVLT-GR-RALEKDK--TSRE-RYLKDLVDE------IKESPSGSSQKTRHPAVAFPVETKPPGMPSPAVS--------- D_rerio_ENSDARP00000067130 HSNLGYLPEEYIRD---GKLS------VKLDVYSLGVVILETCT-GQ-KVKQESS----KN-LFLRDVLHS------EVEE-------------------------KGCVDACLRFLDL- P_troglodytes_ENSPTRP00000025212 RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----SP-VYLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- H_sapiens_ENSP00000256458 RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----SP-VYLKDLLLS------DIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- D_melanogaster_FBpp0084549 FGTKIYLPPEFRNF---RQLS------TGVDVYSFGIVLLEVFT-GR-QVTDRVP--ENETKKNLLDYVKQ--------------------------------QWRQNRMELLEKHLAA- C_familiaris_ENSCAFP00000007680 QASAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----SP-VYLKDLLLG------EIPS-STTSLGCRKTGV----------EKVMAKEICRKYLEK- M_mulatta_ENSMMUP00000026192 QASVAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----SP-VYLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- M_domestica_ENSMODP00000033729 QAVAAYVPEDFLRV---GQLT------ERVDIFSCGIVLAEILT-SI-PAMDKER----TP-VFLKDLLIS------EIPS-PKTLLCSKNKCV----------EKLAAKEICQKYQDA- A_aegypti_AAEL007642-PA SGTGPYISPEAMR----GTVT------PALDVYSYGVVLAEMVT-GE-EVLCEVL------PEGVGDLIERVTARGAD----------------------------------LESMVDR- T_guttata_ENSTGUP00000014323 QASLTYLPEDFVRH---GQLT------EKVDIFSCGVVLAEILT-GI-KALDEDR----HP-IYLKDMIAD------EIQS-AKEGSNSKVKNL----------EKLAAKEICCKYLDR- B_taurus_ENSBTAP00000008135 QASTAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----NP-VYLKDLLLH------EIPS-STISLCSRKMGV----------EKEMAKEICQKYLEK- M_musculus_ENSMUSP00000055073 QASAAYLPEHFIRV---GQLT------KQVDIFSCGIVLAEVLT-GI-PAMDKDR----SP-VYLKDLLLS------EIPN-STSSVCSRKTSM----------GKAVVKEICQRHVEK- A_carolinensis_ENSACAP00000014667 QVSLAYFPEDFVRH---GQLT------EKVDIFGCGIVLAEILT-GM-KAMDEER----YP-VFLKDVLLE------EIQA-AKKLSSSKERTF----------EQVAAMEIYHKYQDK- G_gorilla_ENSGGOP00000006760 SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----KH-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- G_aculeatus_ENSGACP00000025500 HSNLGYLSEEYIRD---GKLS------FSLDVYGFGMVIMETVT-GR-KVTGEVS----KK-TPLRDLLVT------EVED-------------------------SGGVDSCLQFLDE- T_guttata_ENSTGUP00000011997 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- O_anatinus_ENSOANP00000021129 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- G_gallus_ENSGALP00000020950 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- B_taurus_ENSBTAP00000029006 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- E_caballus_ENSECAP00000003689 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- X_tropicalis_ENSXETP00000003054 QVHQPYLPDSFFRH---GQLT------VQTDIFSCGVVLAEILT-GQ-KACDKSR----NP-VYLKDLFLE------ELER-AKEYLDSDGKQA-----DHESPESLCSHQISRKYIDS- H_sapiens_ENSP00000288602 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- P_troglodytes_ENSPTRP00000033866 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- C_familiaris_ENSCAFP00000005841 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- P_pygmaeus_ENSPPYP00000020265 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- M_musculus_ENSMUSP00000002487 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- R_norvegicus_ENSRNOP00000014604 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- A_carolinensis_ENSACAP00000011088 SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- T_nigroviridis_ENSTNIP00000000196 SGSILWMAPEVIRMQDSNPYT------FQSDVYAYGVVLFELMS-GS-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- T_rubripes_ENSTRUP00000004441 SGSILWMAPEVIRMQDSNPYT------FQSDVYAYGVVLFELMS-GS-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- D_melanogaster_FBpp0079568 LLPVRWMPSESILY---GKFT------TESDVWSFGVVLWEIYSYGM-QPYYGFS----NQ-EVINLI--------------------------------------------RSRQLLS- O_latipes_ENSORLP00000020929 SGSILWMAPEVIRMQDNNPYT------FQSDVYAYGVVLFELMS-GT-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- O_cuniculus_ENSOCUP00000012185 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- G_aculeatus_ENSGACP00000000078 SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFEILT-GE-LPYSLIA----TRDQIIFMV--------------------------------------------GRGYLSP- A_carolinensis_ENSACAP00000011023 GGSILWMSPEVIRMQDPNPYS------FQSDVYSYGVVLYELLS-GS-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYLSP- R_norvegicus_ENSRNOP00000013831 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- H_sapiens_ENSP00000251849 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- M_mulatta_ENSMMUP00000009777 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- P_pygmaeus_ENSPPYP00000014975 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- E_caballus_ENSECAP00000010011 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- M_musculus_ENSMUSP00000108571 TGSVLWMAPEVIRMQDDNPFS------FQSDVYSYGIVLYELMA-GE-LPYAHIN----NRDQIIFMV--------------------------------------------GRGYASP- C_familiaris_ENSCAFP00000007376 TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- O_latipes_ENSORLP00000012350 SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GS-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- B_taurus_ENSBTAP00000005930 TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- M_domestica_ENSMODP00000007826 TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- G_gallus_ENSGALP00000007991 TGSILWMAPEVIRMQDSNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- D_rerio_ENSDARP00000048390 SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GA-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- M_domestica_ENSMODP00000011339 NKYLLYMPEEYIRQ---RRLS------IKTDVYSFGIVIMEVLT-GY-QVVLEGP----KY-VRLRDLLVE------LMEK-------------------------RG-LESCLSLLDK- G_aculeatus_ENSGACP00000004834 SGSILWMAPEVIRMQDSNPYT------FQSDVYGYGVVLFELMS-GT-LPYCNIN----NRDQIIFMV--------------------------------------------GRGYLSP- A_carolinensis_ENSACAP00000013056 TGSVLWMAPEVIRMQDSNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- T_nigroviridis_ENSTNIP00000010036 SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GV-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- T_rubripes_ENSTRUP00000029372 SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GV-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- D_rerio_ENSDARP00000044241 SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFELMT-GE-LPYSQIG----NRDQIIFMV--------------------------------------------GRGYLSP- P_troglodytes_ENSPTRP00000025252 TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQIIFMV--------------------------------------------GRGYASP- T_rubripes_ENSTRUP00000016249 SGSILWMSPEVIRMQDNNPYS------FQSDVYSYGIVLFELMT-GE-LPYSQTG----NRDQIIYMV--------------------------------------------GRGYLSP- G_aculeatus_ENSGACP00000025456 SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GA-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- T_nigroviridis_ENSTNIP00000015593 SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFELMA-GE-LPYSQTG----NRDQIIYMV--------------------------------------------GRGYLSP- T_rubripes_ENSTRUP00000004702 KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIVTYGK-NPYPGMT----KG-EVISSI--------------------------------------------QRGYRMP- A_gambiae_AGAP011710-PA VGNPYWMAPEMMRG---NKYD------EKVDIFSFGIMLCEIIG-RV-QADPDYL-------PRLPDFGLN-----------------------------------------EKVFREK- O_latipes_ENSORLP00000014365 SGSILWMAPEVIRMEDNNPYS------FQSDVYSYGIVLFELMT-GELLPYINTR----GNDQIIFMV--------------------------------------------GRCCLSP- D_rerio_ENSDARP00000008826 KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTYGR-VPYPGMT----NP-EVIRNL--------------------------------------------DRNYRMP- E_caballus_ENSECAP00000003552 TGSVLWLAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----NRDQILFMV--------------------------------------------GRGYASP- D_rerio_ENSDARP00000071167 CGCLLHMAPEVIRMQDTNPYT------FQSDVYGYGVVLYELMS-GT-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- C_familiaris_ENSCAFP00000011788 KFPIKWTAPEAIHF---GVFT------IKADVWSFGILLMEIVTYGR-VPYPGMS----NP-EVIRSL--------------------------------------------ERGYRMP- O_latipes_ENSORLP00000015921 KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIITFGK-IPYPGMT----KG-EVVSSI--------------------------------------------QRGYRMP- O_anatinus_ENSOANP00000008740 KFPIKWTAPEAINF---GSFT------IKSDVWSFGILLYEIVTYGK-IPYPGRT----NA-DVMTAL--------------------------------------------QQGYRMP- O_latipes_ENSORLP00000021561 AGTLSYMAPEHLRSIH-TPST------EKSDVYSFGIVVWVILT-GE-EPYANAR----SEDQISRCV--------------------------------------------RDGDRPA- M_domestica_ENSMODP00000011408 KFPIKWTAPEAINF---GSFS------IKSDVWSFGILIYEIITYGK-VPYPGRT----NA-EVIMAL--------------------------------------------GKGYRMP- A_gambiae_AGAP006219-PA LLPVRWMPSESILY---GKFT------TESDVWSFGVVLWEIYSYGL-QPYYGYS----NQ-EVINMV--------------------------------------------RARQLLP- G_aculeatus_ENSGACP00000018983 KFPIKWTAPEAINY---GTFT------IKSDMWSFGVLLFEIITYGK-IPYPGMT----KG-EVISSV--------------------------------------------QRGYRMP- C_familiaris_ENSCAFP00000015667 KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----NP-EVIQNL--------------------------------------------ERGYRMV- B_taurus_ENSBTAP00000037887 KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----NP-EVIQNL--------------------------------------------ERGYRMV- M_musculus_ENSMUSP00000100967 RLPVKWTAPEALKN---GRFS------SKSDVWSFGVLLWEVFSYGR-APYPKMS----LK-EVSEAV--------------------------------------------EKGYRME- R_norvegicus_ENSRNOP00000027730 RLPVKWTAPEALKN---GRFS------SKSDVWSFGVLLWEVFSYGR-APYPKMS----LK-EVSEAV--------------------------------------------EKGYRME- C_elegans_F33E2.2a CGTVSWMAPEMIKK---QPCN------EKVDVYSFGVVLWEMLT-RE-TPYANIA----QM-AIIFGV--------------------------------------------GTNILSL- C_intestinalis_ENSCINP00000023589 TGTYPWMAPELIQG---LPTS------ELCDVYSFGVVLWEMLT-RE-VPFKGLQ----GF-QVAWVVV-------------------------------------------ENGERPT- A_aegypti_AAEL000187-PA VGNPYWMAPEMMRG---NKYD------EKVDIFSFGIMLCEIIG-RV-QADPDYL-------PRTSDFGLN-----------------------------------------QAVFKEK- X_tropicalis_ENSXETP00000010512 SGSILWMAPEVIRMQDNNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----NRDQIIFMV--------------------------------------------GRGYLSP- P_pygmaeus_ENSPPYP00000020565 KFPIKWTAPEAIHF---GVFT------IKADVWSFGVLLMEVVTYGR-VPYPGMS----NP-EVIRNL--------------------------------------------ERGYRMP- D_rerio_ENSDARP00000095291 SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLYELMT-GE-LPYSMIG----NRDQVRGLV--------------------------------------------GRGYLSP- T_rubripes_ENSTRUP00000007128 KFPIKWTAPEAALY---GRFT------IKSDVWSFGILLTELVTKGR-VPYPGMV----NR-EVLEQV--------------------------------------------ERGYRMP- O_latipes_ENSORLP00000020461 AGTVAWMAPEVIRN---EPVS------EKVDIWSFGVVLWELLT-GE-IPYKDVD----SS-AIIWGV--------------------------------------------GSNSLHL- O_latipes_ENSORLP00000021875 KFPIKWTAPEAINF---GTFT------IKSDVWSFGILLTEIVTYGR-IPYPGMS----NP-EVIQNL--------------------------------------------ERGYRMP- C_intestinalis_ENSCINP00000011940 KIPIRWTAPEAITK---QQFS------IKSDVWSFGILLTEIIGKGR-VPYPGMD----NK-EVLEQL--------------------------------------------ERGYRME- H_sapiens_ENSP00000259089 KFPIKWTAPEAIHF---GVFT------IKADVWSFGVLLMEVVTYGR-VPYPGMS----NP-EVIRNL--------------------------------------------ERGYRMP- A_aegypti_AAEL004592-PA RFPVKWTAPEAIVY---GKFS------IKSDVWSYGILLMELFTYGQ-VPYPGMH----SR-EVIEQI--------------------------------------------ERGYRMP- T_rubripes_ENSTRUP00000008303 KFPIKWTAPEAALY---GKFT------IKSDVWSFGILLMELVTKGR-VPYPGMN----NR-EVLEQV--------------------------------------------ERGYRMP- X_tropicalis_ENSXETP00000003560 AGTPSYMAPEALTDLN-YKPT------MAFDVYSFGIMIWAVLS-GE-EPFPNAH----PA-LIQLHI--------------------------------------------PNGQRPSL X_tropicalis_ENSXETP00000046976 VGTRRYMAPEVLE----GAINFQRDAFLRIDMYAFGLVLWELAS-RC-TASDG------PVDEYMLPF---------EEEV--------------------------------------- T_nigroviridis_ENSTNIP00000019431 KFPIKWTAPEAINF---GTFS------IKSDVWSFGILLTEIVTFGR-IPYPGMT----NP-EVIRNL--------------------------------------------ERLYRMP- T_rubripes_ENSTRUP00000004157 VGTRRYMAPEVLE----GTITFHRDAFLRIDVYALALVLWELAS-RC-TAVDEQG----PVDEYMLPF---------EEEV--------------------------------------- P_pygmaeus_ENSPPYP00000001840 KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----NP-EVIQNL--------------------------------------------ERGYRMV- E_caballus_ENSECAP00000020913 KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----NP-EVIQNL--------------------------------------------ERGYRMV- T_rubripes_ENSTRUP00000030627 AGTVAWMAPEVIRN---EPVS------EKVDIWSFGVVLWELLT-GE-IPYKDVD----SS-AIIWGV--------------------------------------------GSNSLHL- T_nigroviridis_ENSTNIP00000020756 KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIITYGK-IPYPGMT----KG-EVISSI--------------------------------------------QRGYRMP- 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMTAS--------------------- P_troglodytes_ENSPTRP00000008285 K--M-NDADST--SV--ET-MYS-VASECLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMTAS--------------------- M_mulatta_ENSMMUP00000000286 K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMTDS--------------------- E_caballus_ENSECAP00000012782 K--M-NDIDST--SV--ET-MYS-VASQCLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMTTS--------------------- C_familiaris_ENSCAFP00000014260 K--M-NDTDPT--SI--ET-MYS-VASQCLHEKKNKRPDIE---------------------------------------------KVVQQLLQDLTAS--------------------- P_pygmaeus_ENSPPYP00000005053 K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMTAS--------------------- B_taurus_ENSBTAP00000028115 K--M-NDIDST--SI--ET-MYS-VASQCLHEKKNKRPDIK---------------------------------------------K-VQQLLEEMTGS--------------------- R_norvegicus_ENSRNOP00000007932 K--M-SDADPA--SV--EA-MYS-VASQCLHEKKNRRPDIA---------------------------------------------K-VQQLLQETSA---------------------- M_musculus_ENSMUSP00000074471 K--M-SDADPA--SV--EA-MYS-AASQCLHEKKNRRPDIA---------------------------------------------K-VQQLLQEMSA---------------------- M_domestica_ENSMODP00000023115 K--M-NDVDST--SV--EN-MYS-IATLCLHEKKNKRPDTE---------------------------------------------M-VKHHLQKMTSS--------------------- G_gallus_ENSGALP00000015600 K--M-SDWDAT--SV--HK-MYS-LADQCLNEKKNRRPNMK---------------------------------------------M-VQQYLQEIKT---------------------- T_guttata_ENSTGUP00000006104 K--M-SDWDVP--SI--HK-MYS-IADRCLNDKKNRRPDIK---------------------------------------------M-VQQQLQEIKT---------------------- A_carolinensis_ENSACAP00000002933 K--M-SSWSMA--SV--EQ-MYS-IACQCLNEKKNRRPDIK---------------------------------------------M-VKQHLEEMAFE--------------------- T_nigroviridis_ENSTNIP00000019071 K--M-EDVDFS--QA--ES-VYT-LACSCLQDRKNQRPLSK---------------------------------------------QVGRGRTHSLTWS--------------------- O_latipes_ENSORLP00000003907 K--M-SDWTKG--QV--ES-IYC-LASNCLHERKNRRPVIK---------------------------------------------Q-VWEYLVGRDRKCHAE----------------- G_aculeatus_ENSGACP00000005326 K--M-SDWEPS--QV--ES-VYS-LAGSCLHDRKNRRPVIE---------------------------------------------Q-VDTQILLLNLPNNPVKTR-------------- T_rubripes_ENSTRUP00000042842 K--M-EDVQLG--QA--ES-VYT-LACSCLQDRKNQRPVSK---------------------------------------------Q-SVTRLQYVHLQHLHR----------------- O_cuniculus_ENSOCUP00000003553 K--M-SDAEPS--SV--ES-MYS-VACQCLHEKKNKRPDIK---------------------------------------------K-VQQLLQEMIPS--------------------- O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 ---RAGPWSNG--VD--DS-IYE-LSSQCLDFRYKRRPTMH---------------------------------------------K-VLSELSAMLCKTEDPQR--------------- X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 K--A-GHLLEE--VA--VD-FAS-AICLCLR---KKNLNIA---------------------------------------------E-VREIMEMAENKLK-EHY--------------- H_sapiens_ENSP00000358997 R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYERLEKLQAVV-------------------- P_pygmaeus_ENSPPYP00000023353 R--P-GPCPPE--LG--LG-LGR-LACCCLHRRAKRRPPMT------------------------------------------------------------------------------- B_taurus_ENSBTAP00000021407 R--P-GPCPPQ--LG--LA-LGQ-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYQTLEELQVVV-------------------- C_elegans_K09B11.1 APPLVGDEEKS--FL--DA-LIE-VGLAGANNDRKVRPTMS---------------------------------------------Q-IVEYLCKNSIPPVV------------------ C_familiaris_ENSCAFP00000000535 K--V-HPCPRN--FS--AK-LFS-LAGQCATSRAKLRPSMD---------------------------------------------E-VLTTLESTQASLY-FAEDP------------- D_rerio_ENSDARP00000092301 RLTA-KDAPAT--HG--SADIAR-LACQCLERRRKKRPRMT---------------------------------------------D-VFKALQDVHSGLK-ISDRSTTINKSPVA---- G_gorilla_ENSGGOP00000000218 R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYERLEKLQAVV-------------------- E_caballus_ENSECAP00000007763 R--P-GPCPPE--LG--LA-LGQ-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYERLEKLQVAV-------------------- M_mulatta_ENSMMUP00000026705 R--P-GPCPPE--LG--LG-LGR-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYERLEKLQAVV-------------------- O_anatinus_ENSOANP00000017468 V--A-GPCPEE--LA--RE-LGQ-LACRCLHRRGKRRPLMT---------------------------------------------E-VYERLEKLQTRG-------------------- X_tropicalis_ENSXETP00000031192 R--V-WQHAKE--VT--QE-LSQ-LACRCLGRQ-KKRPNMQ---------------------------------------------E-VFLTLKRLQEHLH-RRHLGKGHGISFTPP--- R_norvegicus_ENSRNOP00000005686 K--I-PPCPRN--FS--AK-LFS-LAGQCVATRAKLRPTMD---------------------------------------------E-VLNTLESTQPSLY-FAEDP------------- M_musculus_ENSMUSP00000033769 R--P-GPCPPQ--LG--LA-LAQ-LACCCMHRRAKKRPPMTQRQNSQHS------LLALWLYLGRCSVELSGKGLLLCWMSLRSQEQ-VYKRLEGLQAG--------------------- G_aculeatus_ENSGACP00000001480 RLIPGDAAEPP--GC--ME-LVD-LACKCLDKKRKKRPAMT---------------------------------------------E-V------------------------------- A_carolinensis_ENSACAP00000012253 Q--A-GPCPEL--LG--IM-IGR-LACQCLHPRAKRRPPMA---------------------------------------------E-VYQELERLQ----------------------- M_domestica_ENSMODP00000037830 R--P-GKCPPE--LG--QE-LGR-LACRCLHRRGKRRPPMTKVQMAPGAEGGPGVRPALGALLAVCSRALPQAPLSFLILLMPPERK-IYESLEKLQASV-------------------- R_norvegicus_ENSRNOP00000053167 R--P-GPCPPQ--LG--LA-LAQ-LACCCMHRRAKKRPPMTQRQNSQ-S------LLPLWLCLGRRSLELSGKGLLLCWVGLRSQEQ-VYKRLEGLQAV--------------------- M_musculus_ENSMUSP00000020448 K--I-PPCPRN--FS--AK-LFS-LAGRCVATKAKLRPTMD---------------------------------------------E-VLSSLESTQPSLY-FAEDP------------- B_taurus_ENSBTAP00000033611 K--V-PPCPQN--FS--AK-LFS-LAGRCAATRAKLRPSMD---------------------------------------------E-VLNILESTQASLY-FAEDP------------- A_gambiae_AGAP002966-PA ---SLPMDAEALMCC--FK-LLQ-VGRVCTADDPKQRPDMV---------------------------------------------G-VMWQLSAA------------------------ C_familiaris_ENSCAFP00000028744 R--P-GPCPPE--LG--LV-LGQ-LACCCLHRRAKRRPPMT------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008814 K--V-PPCPRN--FS--AK-LFC-LAGWCAATRAKLRPSMD---------------------------------------------E-VLNTLESTQASLY-FAEDP------------- H_sapiens_ENSP00000261233 K--V-PPCPRN--FS--AK-LFC-LAGRCAATRAKLRPSMD---------------------------------------------E-VLNTLESTQASLY-FAEDP------------- M_mulatta_ENSMMUP00000021862 K--V-PPCPRN--FS--IK-LFC-LAGQCAATRAKLRPSMD---------------------------------------------E-VLNTLESTQASLY-FAEDP------------- T_rubripes_ENSTRUP00000016336 ---E-GATEPA--GW--ME-MVA-LACRCLANNRKGRPAMA---------------------------------------------E-VFDKLQDINTLVK-R----------------- A_gambiae_AGAP003062-PA A--AVGRDGEARWCEAGRK-LLE-IAIKCMGEKWS-RPNSG---------------------------------------------A-LADAVAGIQLVPL------------------- P_pygmaeus_ENSPPYP00000005399 K--V-PPCPRN--FS--AK-LFC-LAGRCAATRAKLRPSMD---------------------------------------------E-VLNTLESTQASLY-FAEDP------------- O_anatinus_ENSOANP00000009429 K--V-EACPRN--FS--AK-LLT-LAGQCATSRAKSRPSMD---------------------------------------------E-VLETLETTRPALY-FTEDP------------- G_gallus_ENSGALP00000035437 K--A-GHLLEE--VA--ID-FAS-ATCLCLK---KKNSNIT---------------------------------------------E-VLEIMETAENKLR-EHY--------------- P_troglodytes_ENSPTRP00000038647 R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT---------------------------------------------Q-VYERLEKLQAVV-------------------- P_pygmaeus_ENSPPYP00000015274 G--A-GRLPED--CA--EA-LAT-AACLCLR---KRNTSLQ---------------------------------------------E-VRGSVAAVEEWLR-GRE--------------- E_caballus_ENSECAP00000010808 R--A-GRLPEG--CA--EA-LAT-AACLCLR---RRNASLA---------------------------------------------E-VCGSVAAVEEKLR-GQD--------------- T_nigroviridis_ENSTNIP00000007783 ---AGGASEPA--GW--ME-MVA-LACMCLDKNRKRRPAMA---------------------------------------------E-VGDRLPRLPAPCP------------------- D_rerio_ENSDARP00000067130 ---KFEHWPPA--VA--LC-LLR-LGLECTGSKMRVRPDME---------------------------------------------M-VLQRLIPLHPLPA-FSEDQ------------- P_troglodytes_ENSPTRP00000025212 G--A-GRLPED--CA--EA-LAT-AACLCLR---RRNTSLQ---------------------------------------------E-VCGSVAAVEERLR-GRE--------------- H_sapiens_ENSP00000256458 G--A-GRLPED--CA--EA-LAT-AACLCLR---RRNTSLQ---------------------------------------------E-VCGSVAAVEERLR-GRE--------------- D_melanogaster_FBpp0084549 ---PMGKELDMCMCA--IE-----AGLHCTALDPQDRPSMN---------------------------------------------A-VLKRFEPFVTD--------------------- C_familiaris_ENSCAFP00000007680 R--A-GRLLED--CA--ET-LAL-AACLCLR---RRNACLA---------------------------------------------E-VCGSVAAVEERLR-GQE--------------- M_mulatta_ENSMMUP00000026192 G--A-GRLPED--CA--KA-LAT-AACLCLR---KRNISLQ---------------------------------------------E-VRGSVAAVEERLR-GWE--------------- M_domestica_ENSMODP00000033729 K--A-GYLPEN--CA--VD-FAT-AVYLCLQ---KKTPNLT---------------------------------------------Q-VCAIVAELNRQIR-NPQ--------------- A_aegypti_AAEL007642-PA ---KVSQHELSEWLTYGKE-LLK-LSNWCLRERFK-RPSAA---------------------------------------------A-VRECVQKMKQGIC------------------- T_guttata_ENSTGUP00000014323 K--A-GHLLEE--VA--VD-FAS-AICLCLR---KKNLNIA---------------------------------------------E-VREIMEMAENKLK-EHY--------------- B_taurus_ENSBTAP00000008135 R--A-GRLPEA--HA--EA-LVM-AACLCLR---RRNASLA---------------------------------------------E-VCSSVAAVEEQLR-GQE--------------- M_musculus_ENSMUSP00000055073 R--A-GLLPEA--CE--EA-WAT-AVSVCLR---RRNASVE---------------------------------------------E-ARVSLAGVEEQLR-GQL--------------- A_carolinensis_ENSACAP00000014667 Q--A-AGLPET--AG--VH-LAM-AACVCLR---KKNADLA---------------------------------------------E-V------------------------------- G_gorilla_ENSGGOP00000006760 K--V-PPCPRN--FS--AK-LFC-LAGXCAATRAKLRPSMD---------------------------------------------E-VLNTLESTQASLY-FAEDP------------- G_aculeatus_ENSGACP00000025500 T--A-GCWPTA--VA--LD-LLR-LALDCTASRHRSRPSMQ---------------------------------------------K-VLLALSKLLPPPSCLIADQ------------- T_guttata_ENSTGUP00000011997 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- O_anatinus_ENSOANP00000021129 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- G_gallus_ENSGALP00000020950 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- B_taurus_ENSBTAP00000029006 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- E_caballus_ENSECAP00000003689 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- X_tropicalis_ENSXETP00000003054 R--A-GFLSNN--AA--FQ-LSL-AACLCLT---KKRPLLQ---------------------------------------------E-IYTWVEKADQCSR-DSQ--------------- H_sapiens_ENSP00000288602 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- P_troglodytes_ENSPTRP00000033866 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- C_familiaris_ENSCAFP00000005841 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- P_pygmaeus_ENSPPYP00000020265 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- M_musculus_ENSMUSP00000002487 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- R_norvegicus_ENSRNOP00000014604 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- A_carolinensis_ENSACAP00000011088 D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- T_nigroviridis_ENSTNIP00000000196 D--L-SKLYST--SP--KS-MKR-LIVDCLKFKRDERPLFP---------------------------------------------Q-ILVAIEQVQDLLP------------------- T_rubripes_ENSTRUP00000004441 D--L-TKIFST--SP--KS-MKR-LIVDCLKFKRDERPLFP---------------------------------------------Q-ILVAIEQVQDLLP------------------- D_melanogaster_FBpp0079568 A-------PEN--CP--TA-VYS-LMIECWHEQSVKRPTFT---------------------------------------------D-ISNRL----KTWH------------------- O_latipes_ENSORLP00000020929 D--L-SKLYST--SP--KS-MKR-LIVDCLKFKRDERPLFP---------------------------------------------Q-ILVSIEQVQDLLP------------------- O_cuniculus_ENSOCUP00000012185 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSMELLQHSLP------------------- G_aculeatus_ENSGACP00000000078 D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP---------------------------------------------Q-ILSSIELLQHALP------------------- A_carolinensis_ENSACAP00000011023 D--V-SKVPSN--CP--KA-MRR-LMCDCLKFKREERPLFP---------------------------------------------Q-ILASIESLQHSLP------------------- R_norvegicus_ENSRNOP00000013831 D--L-SRLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- H_sapiens_ENSP00000251849 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- M_mulatta_ENSMMUP00000009777 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- P_pygmaeus_ENSPPYP00000014975 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- E_caballus_ENSECAP00000010011 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- M_musculus_ENSMUSP00000108571 D--L-SRLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- C_familiaris_ENSCAFP00000007376 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- O_latipes_ENSORLP00000012350 D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- B_taurus_ENSBTAP00000005930 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- M_domestica_ENSMODP00000007826 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- G_gallus_ENSGALP00000007991 D--L-SKLYKN--CP--KA-MKR-LVADCLKKVREERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- D_rerio_ENSDARP00000048390 D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- M_domestica_ENSMODP00000011339 K--I-SPCPQN--FS--WK-LFT-LANQCASSRAKLRPTMD---------------------------------------------E-VLVALESSCPNLH-FTEDP------------- G_aculeatus_ENSGACP00000004834 D--L-SKLFCT--SP--KS-MKR-LIVDCLKFKRDERPLFP---------------------------------------------Q-ILVAIEQVQDLLP------------------- A_carolinensis_ENSACAP00000013056 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVREERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- T_nigroviridis_ENSTNIP00000010036 D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- T_rubripes_ENSTRUP00000029372 D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- D_rerio_ENSDARP00000044241 D--L-SKLYKR--CP--KA-MKR-LVADCIKKSKDERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- P_troglodytes_ENSPTRP00000025252 D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSSIELLQHSLP------------------- T_rubripes_ENSTRUP00000016249 D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP---------------------------------------------Q-ILSSIELLQHALP------------------- G_aculeatus_ENSGACP00000025456 D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- T_nigroviridis_ENSTNIP00000015593 D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP---------------------------------------------Q-ILSSIELLQHALP------------------- T_rubripes_ENSTRUP00000004702 Q-------TDN--CP--TE-LYS-MMLNCWKEKPEERPTFE---------------------------------------------Y-MQSVL----NDFY------------------- A_gambiae_AGAP011710-PA -------FCGQ--CP--EP-FYK-IAFLCCDLNPDKRPPFH---------------------------------------------V-LQGWLETMATVVALQRPIPIRIIDEIDNFKGL O_latipes_ENSORLP00000014365 D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP---------------------------------------------Q-ILSSIELLQHALP------------------- D_rerio_ENSDARP00000008826 C-------PDA--CP--GE-LYD-IMTKCWMEKPEDRPTFE---------------------------------------------Y-LQDTL----NDFF------------------- E_caballus_ENSECAP00000003552 D--L-SKLYKN--CP--KA-VKR-LVADCVKKVKEERPLFP---------------------------------------------Q-ILSPVELLQHSLP------------------- D_rerio_ENSDARP00000071167 D--L-SKLYSN--CP--KS-MKR-LIIDCLKFKRDERPLFP---------------------------------------------Q-ILVSIEQVQELLP------------------- C_familiaris_ENSCAFP00000011788 R-------PDS--CP--PE-LYHGVIAECWRSRPEERPTFE---------------------------------------------F-LQSVL----EDFH------------------- O_latipes_ENSORLP00000015921 R-------PEN--CP--TQ-LYE-IMTSCWKFRPEDRPTFE---------------------------------------------Y-MQSVL----DDFY------------------- O_anatinus_ENSOANP00000008740 R-------MEN--CP--DE-LYD-IMKMCWKEKAEERPTFD---------------------------------------------Y-LQSVL----DDFY------------------- O_latipes_ENSORLP00000021561 E----DLIPED--TP--SE-VVQ-LMKRCWSDNPEERPSFK---------------------------------------------E-AYDIFCPFYAKNLEPHIENDLQDLKENYEGPM M_domestica_ENSMODP00000011408 R-------MDS--CP--NE-LYD-IMSMCWKERAEERPTFD---------------------------------------------Y-LQSVL----EDYY------------------- A_gambiae_AGAP006219-PA C-------PES--CP--SA-VYS-LMVECWHEQAVRRPTFP---------------------------------------------E-IGHRL----KIWY------------------- G_aculeatus_ENSGACP00000018983 Q-------PGN--CP--NE-LYA-IVMLCWKNKPEDRPTFD---------------------------------------------Y-MQSVL----DDFY------------------- C_familiaris_ENSCAFP00000015667 R-------PDN--CP--EE-LYQ-LMMLCWKERPEDRPTFD---------------------------------------------Y-LRSVL----EDFF------------------- B_taurus_ENSBTAP00000037887 R-------PDN--CP--EE-LYQ-LMMLCWKERPEERPTFD---------------------------------------------Y-LRSVL----EDFF------------------- M_musculus_ENSMUSP00000100967 P-------PDG--CP--GS-VHT-LMGSCWEAEPARRPPFR---------------------------------------------K-IVEKLGRELRSVG------------------- R_norvegicus_ENSRNOP00000027730 P-------PDS--CP--GP-VHT-LMGSCWEAEPSRRPPFR---------------------------------------------K-IVEKLGRELRSVG------------------- C_elegans_F33E2.2a ------PMPEE--AP--KG-LVL-LIKQCLSQKGRNRPSFS---------------------------------------------H-IRQHWEIFKPELFEMTEEEWQLAWDSYREFAK C_intestinalis_ENSCINP00000023589 -------IPEC--CP--GR-FSS-LMRRCWSSTVSERPSFY---------------------------------------------D-IIGELNSMMSDDDLGATTNHFLGSK------- A_aegypti_AAEL000187-PA -------FCEQ--CP--EP-FYK-IAFLCCDLNPDKRPPFN---------------------------------------------I-LEVWFESMAHNATLGKPLPVTIAAEIKYFKGQ X_tropicalis_ENSXETP00000010512 D--F-SKVRSN--CP--KA-MKR-LMADCLKKKRDERPLFP---------------------------------------------Q-ILASIELLARSLP------------------- P_pygmaeus_ENSPPYP00000020565 R-------PDT--CP--PE-LYRGVIAECWRSRPEERPTFE---------------------------------------------F-LQSVL----EDFY------------------- D_rerio_ENSDARP00000095291 D--L-SKLYKS--CP--KA-MKR-LVSDCIQKTKEVVVFFF---------------------------------------------Q-ILSSIELLQHSLP------------------- T_rubripes_ENSTRUP00000007128 C-------PQG--CP--ES-LHE-MMKLCWKKDPDERPTFE---------------------------------------------Y-LQSFL----EDYF------------------- O_latipes_ENSORLP00000020461 ------PVPST--CP--DG-FKI-LMKQTWQGKPRNRPSFR---------------------------------------------Q-ILLHLDIASADILGTPQETYFKSQAEWREEVK O_latipes_ENSORLP00000021875 K-------PEG--CP--DG-LYA-IMCHCWKETPDDRPTFE---------------------------------------------Y-LKDVL----EDFF------------------- C_intestinalis_ENSCINP00000011940 R-------LEK--CS--ED-MYK-IMRDCWDIDPNERPSFE---------------------------------------------I-LEIEL----SDF-------------------- H_sapiens_ENSP00000259089 R-------PDT--CP--PE-LYRGVIAECWRSRPEERPTFE---------------------------------------------F-LQSVL----EDFY------------------- A_aegypti_AAEL004592-PA K-------PTNHTLP--DD-IYS-LMLKCWDAIPEKRPTFE---------------------------------------------F-LNHYF----QNFT------------------- T_rubripes_ENSTRUP00000008303 C-------PQE--CP--NS-MHE-LMLQCWKRDAEERPTFE---------------------------------------------Y-LQAFL----EDYF------------------- X_tropicalis_ENSXETP00000003560 EVLDHLSHIKM--VP--EA--KE-LMIKCWSGNADARPSFL---------------------------------------------E-CSHATKLMFELYS------------------- X_tropicalis_ENSXETP00000046976 -----GQHPSL------ED-MQE------VVVHKKKRPILR---------------------------------------------E-CWQKHAGMAMLCE------------------- T_nigroviridis_ENSTNIP00000019431 R-------PEG--CP--AE-LYE-VMMTCWKEKPEERPTFE---------------------------------------------F-LQNIL----NDFF------------------- T_rubripes_ENSTRUP00000004157 -----GQHPSL------ED-MQE------VVVHNKLRPPLR---------------------------------------------E-CWQKHA-------------------------- P_pygmaeus_ENSPPYP00000001840 C-------PDN--CP--EE-LYQ-LMRLCWKERPEDRPTFD---------------------------------------------Y-LRSVL----EDFF------------------- E_caballus_ENSECAP00000020913 R-------PDN--CP--EE-LYQ-LMMLCWKERPEDRPTFD---------------------------------------------Y-LRSVL----EDFF------------------- T_rubripes_ENSTRUP00000030627 ------PVPST--CP--DG-FKI-LMKQTWQAKPRNRPSFR---------------------------------------------Q-ILLHLDIASADVLGAPQETYFKCQSEWREEVK T_nigroviridis_ENSTNIP00000020756 Q-------PDS--CP--SE-LYH-MMLDCWKDKPDARPTFE---------------------------------------------Y-MQSVL----NDFY------------------- 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008285 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000286 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000012782 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014260 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005053 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028115 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000007932 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000074471 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023115 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015600 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006104 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002933 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019071 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003907 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005326 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042842 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003553 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 --------I----C-GSSTSGFSM-----------------------------------------------------------------------------NTPEETDDETASVSVDVPS H_sapiens_ENSP00000358997 --------AGVPGHSEAAS--CIP-----------------------------------------------------------------------------PSPQENSYVSSTGRAHSG- P_pygmaeus_ENSPPYP00000023353 --------------------------------------------------------------------------------------------------------QENSYVSSTGSAHSG- B_taurus_ENSBTAP00000021407 --------AGPCLELEAAS--RSP-----------------------------------------------------------------------------PSPQENSYVSTSGSALSR- C_elegans_K09B11.1 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000535 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDENQNNHSLPHDK D_rerio_ENSDARP00000092301 --------TPEPLRSDSSSIDSLS------------------------------------------------------------------------HHFSKLRPQEDTYPCV-------- G_gorilla_ENSGGOP00000000218 --------AGVPGHSEAAS--CIP-----------------------------------------------------------------------------PSPQENSYVSSTGSAHSG- E_caballus_ENSECAP00000007763 --------TGLSLEPEAAS--HSP-----------------------------------------------------------------------------PSPQENSYVSTASSALSS- M_mulatta_ENSMMUP00000026705 --------AGVPGHLEAAS--CIP-----------------------------------------------------------------------------PSPQENSYVSSTGGAHSG- O_anatinus_ENSOANP00000017468 --------DQSYGQDTGRS--KGP-----------------------------------------------------------------------------ASPQENSYMFTPHCAPEDR X_tropicalis_ENSXETP00000031192 --CVSTRRGFSPIHELASSVQDLP-----------------------------------------------------------------------------LTPEENTDKYTPCGLSVKG R_norvegicus_ENSRNOP00000005686 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LDNVPSIPVEDDENQNNYPVPPKE M_musculus_ENSMUSP00000033769 ----------PPWELEVAG--HGS-----------------------------------------------------------------------------PSPQENSYMSTTGSAQSG- G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037830 --------G--PSEREAGS--RGP-----------------------------------------------------------------------------ASPQEDSYMFTPNSAPDG- R_norvegicus_ENSRNOP00000053167 ----------PPWKLEVAG--HGS-----------------------------------------------------------------------------PSPQENSYMSTTGSAQSG- M_musculus_ENSMUSP00000020448 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LDNVPSIPVEDDENQNNHSVPPKE B_taurus_ENSBTAP00000033611 --------PTSLKSFRSP--SPLF------------------------------------------------------------------------FDNVPSIPVEDDENQNNPSPPHDQ A_gambiae_AGAP002966-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028744 --------------------------------------------------------------------------------------------------------QENSYVSVPSSG---- P_troglodytes_ENSPTRP00000008814 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDESQNNNLLPSDE H_sapiens_ENSP00000261233 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDESQNNNLLPSDE M_mulatta_ENSMMUP00000021862 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDESQNNHLLSSDE T_rubripes_ENSTRUP00000016336 --------SSPHMDLSGACL---S-----------------------------------------------------------------------------KEPAQSSQSSSCSSSCSL- A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDESQNNNLLPSDE O_anatinus_ENSOANP00000009429 --------PASLRSFRPP--SPLF------------------------------------------------------------------------LDLLPSVPVEDDENL----PLSGE G_gallus_ENSGALP00000035437 --------I----CGGGSTSGFSM-----------------------------------------------------------------------------NTPEETDDETTNLSVDAPS P_troglodytes_ENSPTRP00000038647 --------AGVPGHSEAAS--CIP-----------------------------------------------------------------------------PSPQENSYVSSTGSAHSG- P_pygmaeus_ENSPPYP00000015274 --------MLLPWSGLSEGTGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSLDASS E_caballus_ENSECAP00000010808 --------TSLPWSGLSEGTGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSFDGSC T_nigroviridis_ENSTNIP00000007783 -------------PLRLAVLVKPT-----------------------------------------------------------------------------RAEAFPSMTSSPNSGLTGQ D_rerio_ENSDARP00000067130 --------PHTLDDTIPPQRPYK------------------------------------------------------------------------------SFPIEDDEMHSQLEELHSP P_troglodytes_ENSPTRP00000025212 --------TLLPWSGLSEGTGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSLDASS H_sapiens_ENSP00000256458 --------TLLPWSGLSEGTGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSLDASS D_melanogaster_FBpp0084549 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007680 --------TLLPSSGLSEGTSSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSLDASY M_mulatta_ENSMMUP00000026192 --------TLLPWSGLSEGTGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSNLDASS M_domestica_ENSMODP00000033729 --------SLLSPSGNSELKNSSV-----------------------------------------------------------------------------NTPEETDD-VDNVSVEGSS A_aegypti_AAEL007642-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014323 --------I----C-GSSTSGFSM-----------------------------------------------------------------------------NTPEETDDETASVSVDVPS B_taurus_ENSBTAP00000008135 --------TSLPCSGLSEGTGSSF-----------------------------------------------------------------------------NTPEETDD-VDNSSFDGSY M_musculus_ENSMUSP00000055073 --------S-LPWSRVSEATGSSS-----------------------------------------------------------------------------NTPEETDD-VDNSSLSVPS A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 --------PTSLKSFRCP--SPLF------------------------------------------------------------------------LENVPSIPVEDDESQNNNLLPSDE G_aculeatus_ENSGACP00000025500 --------PHSLDDPCDSKPSPPL-----------------------------------------------------------------------------SIPVEHDEQLSPHASPTRA T_guttata_ENSTGUP00000011997 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021129 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020950 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000029006 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003689 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003054 --------NL------------SL-----------------------------------------------------------------------------NVPEESDF-DDSLSLEPME H_sapiens_ENSP00000288602 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000033866 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000005841 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020265 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000002487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014604 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011088 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004441 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0079568 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020929 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000078 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000251849 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000009777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014975 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010011 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108571 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007376 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012350 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000005930 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007826 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007991 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000048390 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011339 --------PKSLKSFRSP--SPLF------------------------------------------------------------------------LNHLPSVPMENDENQDFCSLP-NE G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013056 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010036 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000029372 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016249 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000025456 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015593 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004702 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011710-PA RSTESSLCTTPDGELLTPTNSSTPRPVEERIE------------------------------------------------------PTAQAGPGFVVVDFNDIPKSPHLGKDFSANGDRI O_latipes_ENSORLP00000014365 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008826 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003552 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071167 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000011788 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015921 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008740 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021561 TLVEKMKLLSVRHDSFLTNEQVPL-----------------------------------------------------------------------------DSPAPLVSSDTNVSVPVEA M_domestica_ENSMODP00000011408 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006219-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018983 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015667 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000037887 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33E2.2a CIQYPSTVTRDHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGCFTELKLKESELAEWEKDLTEREQWHNQNSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPC C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA RSNDSSKCTTPDGLATPPASGVKPSLSRKRINEGMMVEEKENCEKTVKPANNDGGVDMVDCAKSPKGAMATKDSVENNNITSSDSTSSSVNVSGF-ILGVTEIPRSPHLSKDFSPNGDRI X_tropicalis_ENSXETP00000010512 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020565 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095291 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000007128 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020461 KHFEKIKSEGTCIHRLDEE-----LIRRRRDELRHALDIREHYERKLERANNLYMELSAIMLQLEVREKELMKREQAVEKKYPGTYKRHLVRPIVRSNAVEKLIKKKGSISHKPGMPTTK O_latipes_ENSORLP00000021875 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000259089 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004592-PA ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000008303 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020913 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030627 KHFEKIKSEGTCIHRLDEE-----LIRRRRDELRHALDIREHYERKLERANNLYMELSAIMLQLEVREKELMKREQAVEKKYPGTYKRHLVRPIVRSNAVEKLIKKKGSLPHKPGMPTAK T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008285 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000286 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000012782 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014260 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005053 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028115 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000007932 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000074471 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023115 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015600 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006104 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002933 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019071 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003907 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005326 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042842 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003553 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 AVGS----------KEESSQAAILTSGSPCAPSTGAVAPDTYGIYMSRVPCESDESSSFMWNPPEKSTEELASHKCSNSEKAAGCDYGIKQGKPAQRLQERSLVCTRGDGILEAAAAAQG H_sapiens_ENSP00000358997 -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL-----------------------------------------------------------S P_pygmaeus_ENSPPYP00000023353 -AAP----------WQPP--AAPSGA---------SAQAAEHLQRGPNQPVESDESLGGL-----------------------------------------------------------S B_taurus_ENSBTAP00000021407 -ASP----------WQPL--AAPLGA---------QAQATDWPQKGANQPVESDESVSDL-----------------------------------------------------------S C_elegans_K09B11.1 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000535 GLRKVGVTQKVPFECSQSEVTFLGFDRKTGSERNEDTCDRPSSS---------------------------------------------------------------------------- D_rerio_ENSDARP00000092301 --------------HKPVFHTLTTTVTTESGCSVSQLNEESWASQSSGVPCESDES-QGF-----------------------------------------------------------S G_gorilla_ENSGGOP00000000218 -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL-----------------------------------------------------------S E_caballus_ENSECAP00000007763 -TSL----------RPPL--AVPSGA---------PAQTTERLQKGPNQPVESDESVSSL-----------------------------------------------------------S M_mulatta_ENSMMUP00000026705 -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGLNQPVESDESLGGL-----------------------------------------------------------S O_anatinus_ENSOANP00000017468 VSGP-----------QPL--Q--TKG---------EAYLRGHFRPRPNQPVESDESVSDA-----------------------------------------------------------C X_tropicalis_ENSXETP00000031192 SVQP----------YTPA--HTQHQAKVDSLCSSFSCQSLKTFRGAQNTPVESDESFPDF-----------------------------------------------------------S R_norvegicus_ENSRNOP00000005686 ALRTDRVTQKTPFECSQSEVTFLGLDRNKGNRGSEAACNMPSSS---------------------------------------------------------------------------- M_musculus_ENSMUSP00000033769 -DEP----------WQPL--VVTTRA---------PAQAAQQLQRSPNQPVESDESVPGL-----------------------------------------------------------S G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037830 -GTPLLHSQARAWHRQPP--HSSHGS---------RAQDSKQLWNHPNQPVESDESTPGL-----------------------------------------------------------C R_norvegicus_ENSRNOP00000053167 -DEP----------WQPL--VVTTRA---------PAQAAQQLQRSPNQPVESDESVPGL-----------------------------------------------------------S M_musculus_ENSMUSP00000020448 VLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSS---------------------------------------------------------------------------- B_taurus_ENSBTAP00000033611 SLRKDRMTQKTPFECSQSEVTFLGFDKKTGSRGNEDSSSRSGSP---------------------------------------------------------------------------- A_gambiae_AGAP002966-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028744 -ASP----------RQPL--AAPSGA---------PAQATEWLQKGPNQPVESDESVSGL-----------------------------------------------------------S P_troglodytes_ENSPTRP00000008814 GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------------------------------------------------------------------- H_sapiens_ENSP00000261233 GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021862 GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------------------------------------------------------------------- T_rubripes_ENSTRUP00000016336 --------------QSPHRLRSPSSH-------VSSSSSCSPSPSSFAGPCETDESRGFS-----------------------------------------------------------H A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 GPRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------------------------------------------------------------------- O_anatinus_ENSOANP00000009429 EPNRHGVDRKTPLECSQSEVTFL------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000035437 AGQN----------KDDSTQPVLLASGGQCTPSVGVVPPDTYCEQMSRVPCESDESTSFIWNPEEKSTDELFSNNYNNSENITSSDCRMKERTKANGLRERNVVCIRSDDNLEMAATAHS P_troglodytes_ENSPTRP00000038647 -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL-----------------------------------------------------------S P_pygmaeus_ENSPPYP00000015274 S-------------VSVAPWAGAATPLLPTENGEG------------------------------------------------------------------------------------R E_caballus_ENSECAP00000010808 S-------------MRTAPSAGAAALPPPTEDGEG------------------------------------------------------------------------------------R T_nigroviridis_ENSTNIP00000007783 PGDV----------SAPPPETSTAALQLPQTSQTSLLSPLKNSTAFHCSPVAPVTSLGQEGFCDQSPG---------------------------------------------------- D_rerio_ENSDARP00000067130 RVSK----PADPCECSQSEVTFLSNEDRSFLRDCHQ------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025212 S-------------MSVAPWAGAATPLLPTENGEG------------------------------------------------------------------------------------R H_sapiens_ENSP00000256458 S-------------MSVAPWAGAATPLLPTENGEG------------------------------------------------------------------------------------R D_melanogaster_FBpp0084549 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007680 S-------------MRVAPGAGAAASFLPTEDGEG------------------------------------------------------------------------------------R M_mulatta_ENSMMUP00000026192 S-------------ASVAPWAGPATSLLPTENGEG------------------------------------------------------------------------------------R M_domestica_ENSMODP00000033729 SDEP----------DKNGLWAGAGSSSPQPGYREG------------------------------------------------------------------------------------R A_aegypti_AAEL007642-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014323 AVGT------------------------------------------------------------------------------ASC--GILQKNPP-----RNYLATR------------Q B_taurus_ENSBTAP00000008135 S-------------MRAAPWAGATSSPPLTADEEG------------------------------------------------------------------------------------M M_musculus_ENSMUSP00000055073 L-------------VMMASCPGAASSPLFTGHGAA------------------------------------------------------------------------------------Q A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000025500 RLG----------ECSQSELTYLSDAGGAV------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011997 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021129 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020950 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000029006 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003689 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003054 G--A----------ISKMPCTSTQGSWSMDDHNQRNHYPKTENRDVDRTPCESDDSTLYV-----------------------------------------------------------L H_sapiens_ENSP00000288602 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000033866 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000005841 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020265 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000002487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014604 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011088 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004441 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0079568 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020929 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000078 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000251849 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000009777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014975 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010011 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108571 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007376 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012350 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000005930 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007826 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007991 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000048390 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011339 NLDKDGFAQKTPLECSQSEVTFLGLDRKALGKGKTPVSEVPVSS---------------------------------------------------------------------------- G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013056 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010036 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000029372 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016249 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000025456 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015593 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004702 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011710-PA RDSLRAKRRQRMMLSRENQRKSLDSSLLVAAARLGATDRLM--------------------------------------------------------GEAGFVIHVQNGHLTLNNVRDLE O_latipes_ENSORLP00000014365 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008826 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003552 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071167 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000011788 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015921 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008740 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021561 SIEDLHVINYKPLGDSIQADARQPSELEEKLGRELYYHIHGSYNSDMHPPAASSYYNNAPNHLLQNHVSPLDQSGRPPARDTSSVHSWTKEPVQPTGSDQLFFPLNPVNPSSMASPTPTH M_domestica_ENSMODP00000011408 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006219-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018983 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015667 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000037887 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33E2.2a RGSPYRCSNTSSSSGVQSSPFSRQSSSRSSAGQQTRRSEGANPPKILRNDAIRHSGSYWETLGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIAS C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA RDSIRARRRQRMILNRENQRKSLDSSNL--GLKLNGVDLVINADSSISEPTSLIQIDPNALKQPSSTEDVLNLVKDSLTNNPQLTRRYDESPRAKRYGEKGFIIQMNNGNLTLNNVKDLE X_tropicalis_ENSXETP00000010512 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020565 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095291 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000007128 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020461 KPDLLRSDVIPSLDPLPSPSPLSASPKVSTPPGKTRYRSKPRHRRANSKGSHNEFPAMLIPAAGISEDTQSLQEQPLHHHHHPPNEGQFLPLKGRVEAVVNCANNLRYFGPAAALRSPQT O_latipes_ENSORLP00000021875 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000259089 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004592-PA ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000008303 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020913 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030627 RPDLLRSDGIPSVDPLPSPSLLTASPKVSTPPGKARYRSKPRHRRANSKGSHSEFAGVLKPVAGALEGTQSLKD----HHHHLPTQGPFLPLKGREEAVVNCANNLRYFGPAAALRSPQT T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------------------------------------------------------------------ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008285 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000286 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000012782 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014260 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005053 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028115 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000007932 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000074471 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023115 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015600 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006104 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002933 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019071 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003907 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005326 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042842 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003553 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 TSPQGSTDLDSSSAP------------------------------------------------------------QGKGA---------------------------------------- H_sapiens_ENSP00000358997 AALRSWHL---TPSCPLD-------P-----APLR-------------------------EAGCPQGDT------AGESSWGSGPG---------------------------------- P_pygmaeus_ENSPPYP00000023353 AALRSWHL---TPSCPLD-------P-----APLR-------------------------EAGCPQGDM------AGESSWGSGPG---------------------------------- B_taurus_ENSBTAP00000021407 AALHSWHL---SPSCPAGPGAPSWVP-----APFG-------------------------QAACTQGGA------ARESSCGSGPG---------------------------------- C_elegans_K09B11.1 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000535 ---------------------------------------------------------------------------CKESGSPKHVA---------------------------------- D_rerio_ENSDARP00000092301 QYLTSHCSRSKSVSCGAQ---------------------------------------------------------GIESTKTDISS---------------------------------- G_gorilla_ENSGGOP00000000218 AALRSWHL---TPSCPLD-------P-----APLR-------------------------EAGXPQGAT------AGESSWGSGPG---------------------------------- E_caballus_ENSECAP00000007763 AALHSWHL---TLSCPPA-------P-----ALLG-------------------------QAGCTQGGT------ARESSWGSGPG---------------------------------- M_mulatta_ENSMMUP00000026705 AALRSWHL---TPSCPLG-------P-----APLG-------------------------EASCPQGDT------AGESSWGSGPG---------------------------------- O_anatinus_ENSOANP00000017468 AAVGSLSL---SYTSAQS-------P-----SPPG-------------------------GPGGPTGGTPAAGSLAEPQSWGRGAP---------------------------------- X_tropicalis_ENSXETP00000031192 GSDNSAGPSDQHILYPSG---------------------------------------------------------VQGSISPVLPR---------------------------------- R_norvegicus_ENSRNOP00000005686 ---------------------------------------------------------------------------CEECWCPELAE---------------------------------- M_musculus_ENSMUSP00000033769 ATLHSWHL---TPGSHPS-------P-----ASFR-------------------------EASCTQGGT------TRESSVRSSPG---------------------------------- G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037830 DVLNSWNLNQNSPSVPSLPGGPGERPEAQALCSLR-------------------------QTSCQPEAA------ASGESWGKS------------------------------------ R_norvegicus_ENSRNOP00000053167 ATLHSWHL---TPDSHPS-------P-----VSFR-------------------------EASCTQGGT------TRESSLRSGPG---------------------------------- M_musculus_ENSMUSP00000020448 ---------------------------------------------------------------------------HEECWSPELVA---------------------------------- B_taurus_ENSBTAP00000033611 ---------------------------------------------------------------------------CEESWSPKCAT---------------------------------- A_gambiae_AGAP002966-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028744 AALCSWHM---SPSCP-------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008814 ---------------------------------------------------------------------------CEESWFPKYIV---------------------------------- H_sapiens_ENSP00000261233 ---------------------------------------------------------------------------CEESWFPKYIV---------------------------------- M_mulatta_ENSMMUP00000021862 ---------------------------------------------------------------------------REESWFPKYIV---------------------------------- T_rubripes_ENSTRUP00000016336 PCLQSGHLSQVGPATFWGLVKVGLKA-------------------------------------------------EHPSGGAACGP---------------------------------- A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 ---------------------------------------------------------------------------CEESWFPKYIV---------------------------------- O_anatinus_ENSOANP00000009429 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000035437 TFQPKNADLDSASSS------------------------------------------------------------QGKCR---------------------------------------- P_troglodytes_ENSPTRP00000038647 AALRSWHL---TPSCPLD-------P-----APLR-------------------------EAGCPQGDT------AGESSWGSGPG---------------------------------- P_pygmaeus_ENSPPYP00000015274 LRVIVGREADSSSEA------------------------------------------------------------CVGPEPPQDV----------------------------------- E_caballus_ENSECAP00000010808 PPAGGEIEADSSSEA------------------------------------------------------------CASGEPPRDA----------------------------------- T_nigroviridis_ENSTNIP00000007783 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000067130 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025212 LRVIVGREADSSSEA------------------------------------------------------------CVGPEPPQD------------------------------------ H_sapiens_ENSP00000256458 LRVIVGREADSSSEA------------------------------------------------------------CVGLEPPQDV----------------------------------- D_melanogaster_FBpp0084549 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007680 LQVCGGMQADSSSVA------------------------------------------------------------CAGPEPPQDAT---------------------------------- M_mulatta_ENSMMUP00000026192 LQVIMGREADSSSEA------------------------------------------------------------CVGPEPPKDA----------------------------------- M_domestica_ENSMODP00000033729 CLTNG-IEADSSVGP--------------------------------------------------------------GPSHPQDA----------------------------------- A_aegypti_AAEL007642-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014323 PLPQGSTDLDFSSAP------------------------------------------------------------QGKGAPLS------------------------------------- B_taurus_ENSBTAP00000008135 LLAGGAVEADSSAEA------------------------------------------------------------CAPPEPPQDA----------------------------------- M_musculus_ENSMUSP00000055073 PSTSGRQEADSSSEA------------------------------------------------------------CTGPQTPQNA----------------------------------- A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 ---------------------------------------------------------------------------CEESWFPKYIV---------------------------------- G_aculeatus_ENSGACP00000025500 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011997 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000021129 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000020950 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000029006 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003689 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003054 PTQRSRHLVGAASAI------------------------------------------------------------CDHQPTQSDAL---------------------------------- H_sapiens_ENSP00000288602 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000033866 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000005841 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020265 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000002487 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014604 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011088 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004441 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0079568 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020929 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000078 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000013831 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000251849 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000009777 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014975 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000010011 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000108571 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007376 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000012350 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000005930 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000007826 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000007991 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000048390 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000011339 ---------------------------------------------------------------------------WEDNFSSNHLH---------------------------------- G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000013056 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010036 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000029372 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000025252 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000016249 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000025456 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000015593 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004702 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP011710-PA NCSDFDSSCDTSLNYLEVNGNRVEQQE--------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000014365 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000008826 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003552 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071167 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000011788 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000015921 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008740 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021561 LNASASMSSLQQVNQHLHPHLDRQQSWPVYPVPDT-------------------------FVPDMNASGCGTPSKGFQPQEPGPLFI--------------------------------- M_domestica_ENSMODP00000011408 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP006219-PA ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000018983 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000015667 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000037887 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------------------------------------------------------ C_elegans_F33E2.2a RRRVSTSVNKSTAVPGQPVFFTRDSPSRVPHGVISCSSPRSSSKLNRSSYPSRNAPHQLEDGCCCAHARAPRAKSIAVPMTSSSRARSPTPYDNDFENAESFVDPESPKNLKNLEKIVNL C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL000187-PA GCSDFDSSCDTSLNYIDVNGTCTNDKNLPQVFVYKTKKTPTLTAHVPTSDAICTSSSSTINSSKSKSLSVTIEKPPTNRKPPIAGGATSTSSNMLSLNKNRSFRPMESSSPRYSRHQQPV X_tropicalis_ENSXETP00000010512 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020565 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000095291 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000007128 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000020461 DHLQRRVSGSSPDLISTAMDADTRQRTSSTGSNAVTGAGAGSLCPCCQAHPFPGCLNCQETPPTLNQPELPHYSLLNTQESTKPSLSVTNKDNVLDGVDAKK--AEPQHSVQPALTLPSA O_latipes_ENSORLP00000021875 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000259089 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004592-PA ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000008303 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000020913 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030627 DHMQGRVSGSGPDLISTAVSADTRQQTSSASSNPV--PGSASLCPCCQTHPFPGCLKCQETSPAFERADLPYNSQLPTEDGT-LRLGSTNDDPASGGEATKRPESEEQEAHQQTLPLPTP T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------------------------------------------------------------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000349096 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008285 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000000286 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000012782 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014260 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005053 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000028115 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000007932 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000074471 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023115 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015600 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006104 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002933 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019071 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003907 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005326 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000042842 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003553 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003026 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000023777 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010778 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000358997 -----------------------------------------------------------------------SR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL P_pygmaeus_ENSPPYP00000023353 -----------------------------------------------------------------------FR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL B_taurus_ENSBTAP00000021407 -----------------------------------------------------------------------LQ-----PTAVEGP-----LLGSS--MSSRPPQIVINPARRKMLQKLAL C_elegans_K09B11.1 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000535 -----------------------------------------------------------------------LSQDPGAYGTDVDPSVEAPGHSYRSRPVETSCSCEFSWNECEQYKRE-- D_rerio_ENSDARP00000092301 -----------------------------------------------------------------------VE--------------------------KQPQNVIINPARQRLVQKMEL G_gorilla_ENSGGOP00000000218 -----------------------------------------------------------------------SR-----PTAVE------------------------------------- E_caballus_ENSECAP00000007763 -----------------------------------------------------------------------TR-----PTAVEGSWAALRHRSHRRLLSTRPGR---------------- M_mulatta_ENSMMUP00000026705 -----------------------------------------------------------------------FR-----PTAVEGL-----VLGSSASSSSEPPQIIINPARQKMVQKLAL O_anatinus_ENSOANP00000017468 -----------------------------------------------------------------------AAWGHNFPASVDSG------QGGSGDSLPVSHQIIINPARQKFVQKLAL X_tropicalis_ENSXETP00000031192 -----------------------------------------------------------------------VSVQDPIP------------------PVQYQNQLAVQPRQRHYCNELSG R_norvegicus_ENSRNOP00000005686 -----------------------------------------------------------------------ASQDLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ-- M_musculus_ENSMUSP00000033769 -----------------------------------------------------------------------FQ-----PTTMEGS-----PTGSSSLLSSEPPQIIINPARQKMVQKLAL G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000037830 -------------------------------------------------------------------------------------------------DTSERPQIIINPARQRFVQKLAL R_norvegicus_ENSRNOP00000053167 -----------------------------------------------------------------------FQ-----PTTMEGS-----SMGSSSLLSSEPPQIIINPARQKMVQKLAL M_musculus_ENSMUSP00000020448 -----------------------------------------------------------------------PSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ-- B_taurus_ENSBTAP00000033611 -----------------------------------------------------------------------PSLDLRAPSVHTDTSAEAPGHSYRSRPVETSCSSIFSWNECKLYKKASV A_gambiae_AGAP002966-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000028744 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008814 -----------------------------------------------------------------------PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- H_sapiens_ENSP00000261233 -----------------------------------------------------------------------PSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- M_mulatta_ENSMMUP00000021862 -----------------------------------------------------------------------PSQDLRPFKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQHKKE-- T_rubripes_ENSTRUP00000016336 -----------------------------------------------------------------------GPASASRDRYTVYLCVRACVCACVCVCA-----VLMNPSKQHLLQKKTL A_gambiae_AGAP003062-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005399 -----------------------------------------------------------------------PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEHYKKE-- O_anatinus_ENSOANP00000009429 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000035437 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000038647 -----------------------------------------------------------------------SR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL P_pygmaeus_ENSPPYP00000015274 -----------------------------------------------------------------------TET---------------------------SWQIDINEAKRKLMENILL E_caballus_ENSECAP00000010808 -----------------------------------------------------------------------TET---------------------------SWKIEINEAKRKLMQNILL T_nigroviridis_ENSTNIP00000007783 -----------------------------------------------------------------------GSPRQERQRRSAASLSRCPLCALSSPWSPGPQVVLMNPIKQHFLQKKTL D_rerio_ENSDARP00000067130 -----------------------------------------------------------------------ESDQRVSSSESVHSDSAARLDLYGSWPVECSCSTETEAQACADCCANGF P_troglodytes_ENSPTRP00000025212 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000256458 -----------------------------------------------------------------------TET---------------------------SWQIEINEAKRKLMENILL D_melanogaster_FBpp0084549 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000007680 -----------------------------------------------------------------------TET---------------------------SWKIEINEAKRKLMENILY M_mulatta_ENSMMUP00000026192 -----------------------------------------------------------------------TET---------------------------SWQIEINEAKRKLMENILL M_domestica_ENSMODP00000033729 -----------------------------------------------------------------------TET---------------------------SWEVEVNDAKKKLMENILL A_aegypti_AAEL007642-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000014323 -----------------------------------------------------------------------RET---------------------------SWKIQINDQKKKLMENILL B_taurus_ENSBTAP00000008135 -----------------------------------------------------------------------TET---------------------------SWKIEINEAKRKLMENILL M_musculus_ENSMUSP00000055073 -----------------------------------------------------------------------TET---------------------------SWKIEINEAKRRLMENIVL A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006760 -----------------------------------------------------------------------PSQDLRPYEVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- G_aculeatus_ENSGACP00000025500 -------------------------------------------------------------------------------------------DLYSSWPVQCSCPAESGGLACEDCRANGF T_guttata_ENSTGUP00000011997 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- O_anatinus_ENSOANP00000021129 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- G_gallus_ENSGALP00000020950 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- B_taurus_ENSBTAP00000029006 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- E_caballus_ENSECAP00000003689 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- X_tropicalis_ENSXETP00000003054 -----------------------------------------------------------------------EQTEAVHGNVQFSWQKSREYSDQSADSSSPSWGIIVNKEKEKLLQNFDL H_sapiens_ENSP00000288602 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- P_troglodytes_ENSPTRP00000033866 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- C_familiaris_ENSCAFP00000005841 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- P_pygmaeus_ENSPPYP00000020265 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- M_musculus_ENSMUSP00000002487 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- R_norvegicus_ENSRNOP00000014604 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- A_carolinensis_ENSACAP00000011088 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------------------KIEQSRSEPSLHRAV-HAEDLNPLLF-HTTRL---------------- T_rubripes_ENSTRUP00000004441 ------------------------------------------------------------------------KIEQSRSEPSLHRAV-NAEDLNPLLF-HTTRL---------------- D_melanogaster_FBpp0079568 ------------------------------------------------------------------------EGHFKASNP----------E---------------------------- O_latipes_ENSORLP00000020929 ------------------------------------------------------------------------KIERSRSEPSLHRAV-HAEDLNPLLF-QTTRL---------------- O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- G_aculeatus_ENSGACP00000000078 ------------------------------------------------------------------------KINRSTSEPSLHRAA-HTEDINICTL-TSTRL---------------- A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------------------RIERSASEPALHR----------------------------------- R_norvegicus_ENSRNOP00000013831 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- H_sapiens_ENSP00000251849 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- M_mulatta_ENSMMUP00000009777 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- P_pygmaeus_ENSPPYP00000014975 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- E_caballus_ENSECAP00000010011 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- M_musculus_ENSMUSP00000108571 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- C_familiaris_ENSCAFP00000007376 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- O_latipes_ENSORLP00000012350 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- B_taurus_ENSBTAP00000005930 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- M_domestica_ENSMODP00000007826 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINSCTL-TSTRL---------------- G_gallus_ENSGALP00000007991 ------------------------------------------------------------------------KINRSASEPSLHRAS-HTEDINSCTL-TSTRL---------------- D_rerio_ENSDARP00000048390 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYTC-ASPKT---------------- M_domestica_ENSMODP00000011339 -----------------------------------------------------------------------PSQDSSVCVMNMYLSSES-GNPVLSKLVEPSSSSESYRNKNEEMEKM-- G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------------------KIERSRSEPSLHRAV-HAEDLNPLLF-HTTRL---------------- A_carolinensis_ENSACAP00000013056 ------------------------------------------------------------------------KINRSASEPSLHRAT-HTQDINACTL-TSTKL---------------- T_nigroviridis_ENSTNIP00000010036 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- T_rubripes_ENSTRUP00000029372 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- D_rerio_ENSDARP00000044241 ------------------------------------------------------------------------KINRSASEPSLHRAS-QSEDISSCTL-TSMKL---------------- P_troglodytes_ENSPTRP00000025252 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- T_rubripes_ENSTRUP00000016249 ------------------------------------------------------------------------KINRSASEPSLHRAS-HTEDINACTL-TSTRL---------------- G_aculeatus_ENSGACP00000025456 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- T_nigroviridis_ENSTNIP00000015593 ------------------------------------------------------------------------KINRSASEPSLHRAS-HTEDINACTL-TSTRL---------------- T_rubripes_ENSTRUP00000004702 ------------------------------------------------------------------------TATEGQYQQQP------------------------------------- A_gambiae_AGAP011710-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014365 ------------------------------------------------------------------------KINRSASEPSLHRAS-HPEDINTYTL-TSTKL---------------- D_rerio_ENSDARP00000008826 ------------------------------------------------------------------------IATEGQYEMQP------------------------------------- E_caballus_ENSECAP00000003552 ------------------------------------------------------------------------KINRSASEPSLHRAA-HTKDINACTLTTSPRL---------------- D_rerio_ENSDARP00000071167 ------------------------------------------------------------------------KIERSASEPSLHRAV-HAEDLNPLLL-HTTRF---------------- C_familiaris_ENSCAFP00000011788 ------------------------------------------------------------------------TATEQQYELQP------------------------------------- O_latipes_ENSORLP00000015921 ------------------------------------------------------------------------TATEDQYQHQP------------------------------------- O_anatinus_ENSOANP00000008740 ------------------------------------------------------------------------TATEGQYQQQP------------------------------------- O_latipes_ENSORLP00000021561 -----------------------------------------------------------------------QNASGIQIGNNNTLSIRAFDNPVSSQCVSGSSLSPIQEGLLKFLEDQAV M_domestica_ENSMODP00000011408 ------------------------------------------------------------------------TATEGQYQQQP------------------------------------- A_gambiae_AGAP006219-PA ------------------------------------------------------------------------QAQKRSK----------------------------------------- G_aculeatus_ENSGACP00000018983 ------------------------------------------------------------------------TATEGQYQQQP------------------------------------- C_familiaris_ENSCAFP00000015667 ------------------------------------------------------------------------TATEGQYQPQP------------------------------------- B_taurus_ENSBTAP00000037887 ------------------------------------------------------------------------TATEGQYQPQP------------------------------------- M_musculus_ENSMUSP00000100967 ------------------------------------------------------------------------VSAPAGGQEAEGSAPTRSQDP--------------------------- R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------------------VAAPAGGQEAEGSAPTRSQDP--------------------------- C_elegans_F33E2.2a PESTSYDEALCNSDVTMNPIYTSPITTYSNPCHVELVDEENANDVDLTSSMDSRRSRSDDADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNEM C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------------------EEWKSDIEEKRKELQEKEKELGVKEKEMREREEKLNEWEQKLRQEMR- A_aegypti_AAEL000187-PA EKYVALSSSLSGSGS---------------------------------------------------------NSRTESPSPTSGVSGTQNRSKMSNNRTGILSPESIRKLNARLLETRKL X_tropicalis_ENSXETP00000010512 ------------------------------------------------------------------------KIHRSASEPSLNRAGFQTEDFSLYTC-ASPKT---------------- P_pygmaeus_ENSPPYP00000020565 ------------------------------------------------------------------------TATERQYELQP------------------------------------- D_rerio_ENSDARP00000095291 ------------------------------------------------------------------------KINRSASEPSLHRAT-HTEDMNVCTL-ALTSAFKSSVCVSGTAAEERV T_rubripes_ENSTRUP00000007128 ------------------------------------------------------------------------TATEPQYQPGENL----------------------------------- O_latipes_ENSORLP00000020461 LPRILRPLRKGADESSEEEEGEVDSEVEYPRRQRTHRCMSSFKSYSTFSSENLSVSDGEEGNTSDHSHSGPLEKLSASQEEHLDELLSHTPDIPIDISTQSDGLSDKECAVRRVKTQISL O_latipes_ENSORLP00000021875 ------------------------------------------------------------------------ASTERQYH---------------------------------------- C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000259089 ------------------------------------------------------------------------TATERQYELQP------------------------------------- A_aegypti_AAEL004592-PA ------------------------------------------------------------------------VTSEVPYREV---------Q---------------------------- T_rubripes_ENSTRUP00000008303 ------------------------------------------------------------------------TATEPQYQPGDNL----------------------------------- X_tropicalis_ENSXETP00000003560 ----------------------------------------------------------------------------SEIKGAIRTMEDHTHQLQN------------------------- X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------------------TIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTEDIVTVVTMVTNV T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------------------IATEGQYEMQP------------------------------------- T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------------------TATEGQYQPQP------------------------------------- E_caballus_ENSECAP00000020913 ------------------------------------------------------------------------TATEGQYQPQP------------------------------------- T_rubripes_ENSTRUP00000030627 LPRTLRPLRKGGDESSEEEEGEVDSEVEFPRRQRPHRCMSSFQSCSTFSSENLSVSDGEEGNTSDHSHSGPLEGLSASQEEHLDELLSHTPDIPIDISTQSDGLSDKECAVRRVKTQISL T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------------------TATESQYQQQP------------------------------------- 1810 1820 1830 1840 1850 1860 1870 1880 =========+=========+=========+=========+=========+=========+=========+=========+========= H_sapiens_ENSP00000349096 ----------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008285 ----------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000000286 ----------------------------------------------------------------------------------------- E_caballus_ENSECAP00000012782 ----------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014260 ----------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005053 ----------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000028115 ----------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000007932 ----------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000074471 ----------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023115 ----------------------------------------------------------------------------------------- G_gallus_ENSGALP00000015600 ----------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006104 ----------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002933 ----------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019071 ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003907 ----------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005326 ----------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000042842 ----------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000003553 ----------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000003026 ----------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000015329 ----------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000014885 ----------------------------------------------------------------------------------------- D_rerio_ENSDARP00000023777 ----------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010778 ----------------------------------------------------------------------------------------- H_sapiens_ENSP00000358997 ---YEDGALDSLQLLSSSSLPGLGLEQDR-QGPEESDEFQS------------------------------------------------ P_pygmaeus_ENSPPYP00000023353 ---YEDGALDSLQLLSSSSLPGLGLEQDR-QGPEESDEFQS------------------------------------------------ B_taurus_ENSBTAP00000021407 ---YEDGVLDSLQLLSSSSLPDSGQDLQDRQGPEERDEFRS------------------------------------------------ C_elegans_K09B11.1 ----------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000000535 ----------------------------------------------------------------------------------------- D_rerio_ENSDARP00000092301 ---YEEGRILTSDLLSSGASLYRGMSAQTRE-PEESDEFAS------------------------------------------------ G_gorilla_ENSGGOP00000000218 ----------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007763 --------------RWCRSWPCMRMGSWTAYSCYHQAPSQA------------------------------------------------ M_mulatta_ENSMMUP00000026705 QGFWQWGSLPDLLSGLSSSF-GLGLEQDR-QGPEESDEFQS------------------------------------------------ O_anatinus_ENSOANP00000017468 ---YKDGVLDSLELLSSSSSPGLAPEPRTSKGPEESDDFQS------------------------------------------------ X_tropicalis_ENSXETP00000031192 ---------------SGSSTSGASQGRPRGRATHFEEHVAALLVL-------------------------------------------- R_norvegicus_ENSRNOP00000005686 ----------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000033769 ---YEEGVLDSLQLLSSGFFPGLDLEPEKSQGPEESDEFQS------------------------------------------------ G_aculeatus_ENSGACP00000001480 ----------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012253 ----------------------------------------------------------------------------------------- M_domestica_ENSMODP00000037830 ---YENGVLNSLELLSSSSSPGLGLDQGNKQGPEESDEYQS------------------------------------------------ R_norvegicus_ENSRNOP00000053167 ---YEEGVLDSLQLLSSGFFPGLDLEPEKRKRPEESDEFQS------------------------------------------------ M_musculus_ENSMUSP00000020448 ----------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000033611 SDEDKEESKNC------------------------------------------------------------------------------ A_gambiae_AGAP002966-PA ----------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000028744 ----------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008814 ----------------------------------------------------------------------------------------- H_sapiens_ENSP00000261233 ----------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021862 ----------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000016336 ---YEEGRIETPELLSSEDIYG-GTSSVALTGPEESDEQDW------------------------------------------------ A_gambiae_AGAP003062-PA ----------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005399 ----------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000009429 ----------------------------------------------------------------------------------------- G_gallus_ENSGALP00000035437 ----------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000038647 ---YEDGALDSLQLLSSSSLP-------------ESDEFQS------------------------------------------------ P_pygmaeus_ENSPPYP00000015274 ---YKEEKLDSIELFGP------------------------------------------------------------------------ E_caballus_ENSECAP00000010808 ---YKEKKLDSIELLGL------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000007783 ---YEEGRIRTPELLSSEDIY----EGTSSGAPEESDELDY------------------------------------------------ D_rerio_ENSDARP00000067130 SQSVVYVTIDDDNALPAPNDARNPAKEKMKN---------------------------------------------------------- P_troglodytes_ENSPTRP00000025212 ----------------------------------------------------------------------------------------- H_sapiens_ENSP00000256458 ---YKEEKVDSIELFGP------------------------------------------------------------------------ D_melanogaster_FBpp0084549 ----------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000007680 ---YKEGKLDSIELLGP------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026192 ---YKEEKLDSIELFGP------------------------------------------------------------------------ M_domestica_ENSMODP00000033729 ---YEEEKLNSKELFGS------------------------------------------------------------------------ A_aegypti_AAEL007642-PA ----------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000014323 ---YEEDKLNSSELFES------------------------------------------------------------------------ B_taurus_ENSBTAP00000008135 ---YKEEKLDSIELFGP------------------------------------------------------------------------ M_musculus_ENSMUSP00000055073 ---YKEERLDSSELFGP------------------------------------------------------------------------ A_carolinensis_ENSACAP00000014667 ----------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006760 ----------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000025500 T---------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000011997 ---------------------------PIQAGGYGGFP----V-H-------------------------------------------- O_anatinus_ENSOANP00000021129 ---------------------------PIQAGGYGGFP----V-H-------------------------------------------- G_gallus_ENSGALP00000020950 ---------------------------PIQAGGYGGFP----V-H-------------------------------------------- B_taurus_ENSBTAP00000029006 ---------------------------PIQAGGYGEFA----AFK-------------------------------------------- E_caballus_ENSECAP00000003689 ---------------------------PIQAGGYGAFP----V-H-------------------------------------------- X_tropicalis_ENSXETP00000003054 ---YRDNKLDSGSLFDSI----------------------------------------------------------------------- H_sapiens_ENSP00000288602 ---------------------------PIQAGGYGAFP----V-H-------------------------------------------- P_troglodytes_ENSPTRP00000033866 ---------------------------PIQAGGYGAFP----V-H-------------------------------------------- C_familiaris_ENSCAFP00000005841 ---------------------------PIQAGGYGAFP--------------------------------------------------- P_pygmaeus_ENSPPYP00000020265 ---------------------------PIQAGGYGAFP----V-H-------------------------------------------- M_musculus_ENSMUSP00000002487 ---------------------------PIQAGGYGEFA----AFK-------------------------------------------- R_norvegicus_ENSRNOP00000014604 ---------------------------PIQAGGYGGF---------------------------------------------------- A_carolinensis_ENSACAP00000011088 ---------------------------PIQAGGYGGFS----V-S-------------------------------------------- T_nigroviridis_ENSTNIP00000000196 ---------------------------LP---------------L-------------------------------------------- T_rubripes_ENSTRUP00000004441 ---------------------------LP---------------L-------------------------------------------- D_melanogaster_FBpp0079568 --------------------------------------------M-------------------------------------------- O_latipes_ENSORLP00000020929 ---------------------------M------------------------------------------------------------- O_cuniculus_ENSOCUP00000012185 ---------------------------PV---------------F-------------------------------------------- G_aculeatus_ENSGACP00000000078 ---------------------------PC---------------F-------------------------------------------- A_carolinensis_ENSACAP00000011023 ----------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000013831 ---------------------------PV---------------F-------------------------------------------- H_sapiens_ENSP00000251849 ---------------------------PV---------------F-------------------------------------------- M_mulatta_ENSMMUP00000009777 ---------------------------PV---------------F-------------------------------------------- P_pygmaeus_ENSPPYP00000014975 ---------------------------PV---------------F-------------------------------------------- E_caballus_ENSECAP00000010011 ---------------------------PV---------------F-------------------------------------------- M_musculus_ENSMUSP00000108571 ---------------------------PV---------------F-------------------------------------------- C_familiaris_ENSCAFP00000007376 ---------------------------PV---------------F-------------------------------------------- O_latipes_ENSORLP00000012350 ---------------------------PIQAGGYDGFQ---MGVH-------------------------------------------- B_taurus_ENSBTAP00000005930 ---------------------------PV---------------F-------------------------------------------- M_domestica_ENSMODP00000007826 ---------------------------PV---------------F-------------------------------------------- G_gallus_ENSGALP00000007991 ---------------------------PV---------------F-------------------------------------------- D_rerio_ENSDARP00000048390 ---------------------------PIQAGGYGEFT----AFK-------------------------------------------- M_domestica_ENSMODP00000011339 ----------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000004834 ---------------------------M------------------------------------------------------------- A_carolinensis_ENSACAP00000013056 ---------------------------PI---------------F-------------------------------------------- T_nigroviridis_ENSTNIP00000010036 ---------------------------PIQAGGYGEYTHSGIPVN-------------------------------------------- T_rubripes_ENSTRUP00000029372 ---------------------------PIQAGGYGEFS----AFK-------------------------------------------- D_rerio_ENSDARP00000044241 ---------------------------PV---------------F-------------------------------------------- P_troglodytes_ENSPTRP00000025252 ---------------------------PV---------------F-------------------------------------------- T_rubripes_ENSTRUP00000016249 ---------------------------PV---------------F-------------------------------------------- G_aculeatus_ENSGACP00000025456 ---------------------------PIQAGCYGELMH--ITTI-------------------------------------------- T_nigroviridis_ENSTNIP00000015593 ---------------------------PI---------------F-------------------------------------------- T_rubripes_ENSTRUP00000004702 ----------------------------------------------------------------------------------------- A_gambiae_AGAP011710-PA ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000014365 ---------------------------PV---------------F-------------------------------------------- D_rerio_ENSDARP00000008826 ----------------------------------------------------------------------------------------- E_caballus_ENSECAP00000003552 ---------------------------PV---------------F-------------------------------------------- D_rerio_ENSDARP00000071167 ---------------------------L------------------------------------------------------------- C_familiaris_ENSCAFP00000011788 ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000015921 ----------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000008740 ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000021561 TEEHLYLLTENIGNSWKRCARRLGLKDVEIQTIEHDYYRDGLPEMVHQMLERWKMKEGSIGCTVGKLCRALDGNIKVDVIQKILDMCGL M_domestica_ENSMODP00000011408 ----------------------------------------------------------------------------------------- A_gambiae_AGAP006219-PA --------------------------------------------C-------------------------------------------- G_aculeatus_ENSGACP00000018983 ----------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000015667 ----------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000037887 ----------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000100967 ----------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000027730 ----------------------------------------------------------------------------------------- C_elegans_F33E2.2a RVQAVKMSIKTHRRTGSNPQALIHQCIDEYTTSATDDSDDAGAVRI------------------------------------------- C_intestinalis_ENSCINP00000023589 ----------------------------------------------------------------------------------------- A_aegypti_AAEL000187-PA SNEGETGASNFSTRVRSSGSSEKSMGVHKGGNTQQEKKIRSIVKSKRGEIKAAAI---------------------------------- X_tropicalis_ENSXETP00000010512 ---------------------------PIQAGGYGGFA---IRAL-------------------------------------------- P_pygmaeus_ENSPPYP00000020565 ----------------------------------------------------------------------------------------- D_rerio_ENSDARP00000095291 LTLLSDLLGFLSFYWLVVACHGELTCKQMVYSLYFNKIKLNTHTH-------------------------------------------- T_rubripes_ENSTRUP00000007128 ----------------------------------------------------------------------------------------- O_latipes_ENSORLP00000020461 GKLCSDEHSYENPLQFGDSDCDSSEAECSDATIRNNKVGAPSSW--------------------------------------------- O_latipes_ENSORLP00000021875 ----------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011940 ----------------------------------------------------------------------------------------- H_sapiens_ENSP00000259089 ----------------------------------------------------------------------------------------- A_aegypti_AAEL004592-PA --------------------------------------------D-------------------------------------------- T_rubripes_ENSTRUP00000008303 ----------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000003560 ----------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000046976 DFPPKESSL-------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019431 ----------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000004157 ----------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001840 ----------------------------------------------------------------------------------------- E_caballus_ENSECAP00000020913 ----------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000030627 GKLCSDEHSYENPLQFGDSDCDSSEAECSDATIRNNKVGAPSSW--------------------------------------------- T_nigroviridis_ENSTNIP00000020756 -----------------------------------------------------------------------------------------