>H_sapiens_ENSP00000349096 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITPSTYVRCLNVGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPDAV---PKTAN-----------------TLPSK-E---AITVQ--------------- ------------------------------------------------------------ ---QKQMPFCDKDRTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS --------LE----------------------VSDTRF------HSFSFYELKNVTNNFD ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAAMVDI T---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDI KSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMTAS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000008285 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITPSTYVRCLNVGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPDAV---PKTAN-----------------TLPSK-E---AVTVQ--------------- ------------------------------------------------------------ ---QKQMPFYDKDRTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS --------LE----------------------VSDTRF------HSFSFYELKNVTNNFD ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAAMVDI T---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDI KSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- K--M-NDADST--SV--ET-MYS-VASECLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMTAS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000000286 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITPSTYVRCLNVGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPDAV---PKT-N-----------------TLPSK-E---AVTVQ--------------- ------------------------------------------------------------ ---QKQMPFYDKDRTLMTP--L------QNL-----------EQSYMPLDSS--SPENKS --------LE----------------------VSDTRF------HSFSFYELKNVTNNFD ERPISVG------GNKMGEGGFGVVYKGYVN--------NA--T----VAVKKLAAMVDI T---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGINFLH--------E--NHHIHRDI KSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMTDS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000012782 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITPSTYVRCLNLGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLVQNEFFAP-------ASLL----- LPDAV---PKTVN-----------------ILPSK-E---AITIQ--------------- ------------------------------------------------------------ ---QKQIPLYGKDRTSVIP--V------QNP-----------EQNYVPPDSS--SPENGS --------LE----------------------VSDTRF------HCFSFYELKNVTNNFD ERPVSIG------GNKMGEGGFGVVYKGYVN--------NR--M----VAVKKLAAMVDI S---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----DTPPLSWHMRCKIAHGAANGISFLH--------E--NHHIHRDI KSANILLDEAFTAKISDFGLARASER--------FTQ-------------TVM---TSRI MGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKDEI---EDEEKT-------------------------------IEDYIDK- K--M-NDIDST--SV--ET-MYS-VASQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMTTS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000014260 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITSSTYVRCLNLGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPDAI---PKTPN-----------------TVPSE-E---AVTVQ--------------- ------------------------------------------------------------ ---QQQMPLNGKDRTFVLP--V------QNF-----------EQNYMPPDSS--SPENTS --------LE----------------------GSDTRF------HSFSFYELKNVTNNFD ERPISLG------GNKMGEGGFGVVYKGYVN--------NK--T----VAVKKLAAMVDI S---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIAQGAANGISFLH--------E--NHHIHRDI KSANILLDEDFTAKVSDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDP- K--M-NDTDPT--SI--ET-MYS-VASQCLHEKKNKRPDIE------------------- --------------------------KVVQQLLQDLTAS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_pygmaeus_ENSPPYP00000005053 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITSSTYVRCLNVGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTSELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPDAV---PKTAN-----------------TLPSK-E---AVTVQ--------------- ------------------------------------------------------------ ---QKQMPFYDKERTLMTP--V------QNL-----------EQSYMPPDSS--SPENKS --------LE----------------------VSDTRF------HSFSFYELKNVTNNFD ERPISVG------GNKMGEGGFGVVYKGYVN--------NT--T----VAVKKLAA---- ---------------------------CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIAQDAANGINFLH--------E--NHHIHRDI KSANILLDEAFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYIDK- K--M-NDADST--SV--EA-MYS-VASQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMTAS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000028115 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITASTYVRCLSLGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQI---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DILVQNEFFAP-------ASLL----- LPDAV---PKNVN-----------------TLPSKVT---VVAVQ--------------- ------------------------------------------------------------ ---QKPKPLCGKDRTSVIS--D------ENP-----------EQNYVLPDSS--SPENTS --------LE----------------------FSDTRF------HSFSFFELKDVTNNFD ERPISVG------GNKMGEGGFGVVYKGYVN--------NR--T----VAVKKLAAMVDI S---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DGDDLCLVYVYMPNG SLLDRL-SCLD-----GTPPLSWNMRCKIAQGAANGLSYLH--------E--NHHIHRDI KSANILLDEDFTAKISDFGLARASEK--------FAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYVDR- K--M-NDIDST--SI--ET-MYS-VASQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLEEMTGS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000007932 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S----------KPLTPSTYVRSLNVGILRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQIELFAP-------ATLL----- LPDAV---PQAVH-----------------SLPPR-E---AATVA--------------- ------------------------------------------------------------ ---QAHRPCQEKNRTTVTPALA------QKL-----------EPSCELPDSS--SPGHQS --------VE----------------------FSDTRF------HSFSFYELKSITNDFD ERPVSIG------GNRMGEGGFGVVYKGCVN--------NT--T----VAVKKLGAMVEI S---TE--ELKQQFDQEIKVM--AK--CQHENLVELLGFSS----DSDNLCLVYAYMPNG SLLDRL-SCLD-----GTPPLSWHMRCKIARGAANGIRFLH--------E--NHHIHRDI KSANILLDQDFTAKISDFGLARASAK--------LAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLELIT-GL-AAVDENR----E P-QLLLDIKEEI---EDKEKT-------------------------------IEDCTDE- K--M-SDADPA--SV--EA-MYS-VASQCLHEKKNRRPDIA------------------- --------------------------K-VQQLLQETSA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000074471 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPLTPSTYIRNLNVGILRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFID---PQEGWKKL----- ----------------------AVAIKKP-------------------------SG--DD RYNQFHIRRFEALLQT---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLVQIELFAP-------ATLL----- LPDAV---PQTVK-----------------SLPPR-E---AATVA--------------- ------------------------------------------------------------ ---QTHGPCQEKDRTSVMP--M------PKL-----------EHSCEPPDSS--SPDNRS --------VE----------------------SSDTRF------HSFSFHELKSITNNFD EQPASAG------GNRMGEGGFGVVYKGCVN--------NT--I----VAVKKLGAMVEI S---TE--ELKQQFDQEIKVM--AT--CQHENLVELLGFSS----DSDNLCLVYAYMPNG SLLDRL-SCLD-----GTPPLSWHTRCKVAQGTANGIRFLH--------E--NHHIHRDI KSANILLDKDFTAKISDFGLARASAR--------LAQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLELIT-GL-AAVDENR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYTDE- K--M-SDADPA--SV--EA-MYS-AASQCLHEKKNRRPDIA------------------- --------------------------K-VQQLLQEMSA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000023115 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KTVTSSTYVRCLNVGLIRQL-------------------- ------------------------------------------------------------ ---------------------------------------ADFID---PQEGWKKL----- ----------------------AVDIKKP-------------------------SG--EN RYNQFHIRRFEGLLQN---GKSPTSELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIRNDFLAP-------ARLL----- LPDII---PEIVQ-----------------VLP-Q-E---KLATQ--------------- ------------------------------------------------------------ ---KKLLPPYDKEKTHVKP--V------QNH-----------EHISSSLD-S--SPDRKS --------LE----------------------VSDTRF------QSFSFYELKSVTNNFD ERPMSAG------GNKMGEGGFGVVYKGCIN--------SR--T----VAVKKLTRMTDM C---TE--ELKQQFDQEIKIL--AK--CQHENLVQLLGFSS----DSNDFCLVYVYMPNG SLLDRL-SCLD-----GTEPLSWQTRCKIAQGTANGIYYLH--------A--NNHVHRDI KSANILLDEDFLPKISDFGLARTSAK--------FNQ-------------TVM---TSRI VGTTAYMAPEALR----GEIT------PKSDIYSFGVVLLEIIT-GL-PAVDEQR----E P-QLLLDIKEEI---EDEEKH-------------------------------IEDYIDA- K--M-NDVDST--SV--EN-MYS-IATLCLHEKKNKRPDTE------------------- --------------------------M-VKHHLQKMTSS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000015600 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S----------QPVTAATYVRSLRYGLLRQL-------------------- ------------------------------------------------------------ ---------------------------------------ADLLD---PQEGWKRL----- ----------------------AAAITDP-------------------------AG--DS RYSQAHIRRFEAFVQM---GKSPTCELLYD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIRNQFLAP-------ASLL----- LPEAV---GMAQE--------------VTLPLSSQ-E---TLPVC--------------- ------------------------------------------------------------ ---EKQQPIQEKEVTSVKPVLS------QNT-----------EKQPSAPPCL--SQEISS --------TQ----------------------SSNTDF------HNFWFHDLESVTNNFD ERPESAG------GNKLGEGGFGIVFKGYIN--------GR--N----VAVKKLAAVVDV S---AQ--DLKQQFDQEIEIM--AK--CKHENLVELLGFSS----DGAQPCLVYEYMPNG SLLDRL-ACLD-----GTPPISWNTRCEIAQGTANGINFLH--------D--NNHIHRDI KSANILLTDTYVPKISDFGLARASVT--------FTR-------------TIM---TDRV VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEVIT-GL-PPVDENR----E P-QLLLSIKDEI---EDEEAT-------------------------------IEDYVDV- K--M-SDWDAT--SV--HK-MYS-LADQCLNEKKNRRPNMK------------------- --------------------------M-VQQYLQEIKT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000006104 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------G----------EPVTDSTHVRCLSYGLVRRL-------------------- ------------------------------------------------------------ ---------------------------------------ADFID---PQEGWKKL----- ----------------------AVDITNP-------------------------SG--ES RYSQVHIRRFEAFVQM---GKSPTCELLYD------------------------------ -----------------------W-GTTNCTVADLV------------------------ ---------------------------------DLLIRNQFLAP-------ASLL----- LPEAV---RMPQE--------------VTLPLSSQ-E---TLPIH--------------- ------------------------------------------------------------ ---EKQLPVQEKKVASVKPVLA------QST-----------EKHNSGSSYS--SEENSS --------SQ----------------------SSNTDF------QNFLFHDLESITNNFD ARPESAG------GNKLGEGGFGIVFKGYIN--------GK--N----VAVKKLIAMVDV S---VQ--DLKQQFEQEINIM--AK--CQHENLVELLGFSS----DGAQPCLVYEYMPNG SLLDRL-ACLD-----ETPPIPWNMRCKIVQGTANGINFLH--------E--NNHIHRDI KSANILLTDTYVPKISDFGLARASVT--------FTQ-------------TIM---TERI VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEIIT-GL-PPVDENR----E P-QLLLTIKDEI---EDEEAT-------------------------------IEDYVDV- K--M-SDWDVP--SI--HK-MYS-IADRCLNDKKNRRPDIK------------------- --------------------------M-VQQQLQEIKT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000002933 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPITPSTYVRCLGYGMVKQL-------------------- ------------------------------------------------------------ ---------------------------------------ADFID---PQEGWKKL----- ----------------------AVDIKNP-------------------------SG--DN RYNQMHLRRFEARQQV---GKSPTCELLHD------------------------------ -----------------------W-GTLNCTVSDLV------------------------ ---------------------------------DLLVKNQFLAP-------ARLL----- LPGNV---DLAGV---------------VYPVQFS-E---SVP----------------- ------------------------------------------------------------ ---QITLGTGLKTRTPRKNDFL------LGY-----------VTVFTPPFLF--SEVSTY -----------------------------HFPLLLSGL------QIFLFHELKSFTNNFD DRTVSAG------GNKIGEGGFGVVYKGCTN--------GR--T----VAVKKLTVLADV S---ID--DLKKQFEQEITIM--AK--CQHENLVELLGFSN----DFDQPCLVSDYMPNG SLLDRL-ACLD-----DTPPIPWKTRCNIAQGASNGICFLH--------E--NNHIHRDV KSANILLTEKFVPKLSDFGLARASVK--------FTH-------------TIL---TERI VGTAAYMAPEALR----GEIT------PKSDIFSFGVVLLEIIT-GL-PPVDENR----D P-QLLLTIKEEI---EDEEKT-------------------------------LEDYIDE- K--M-SSWSMA--SV--EQ-MYS-IACQCLNEKKNRRPDIK------------------- --------------------------M-VKQHLEEMAFE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_nigroviridis_ENSTNIP00000019071 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S----------NSVTSATYIRNLSYSLRRQL-------------------- ------------------------------------------------------------ ---------------------------------------SDILD---PQERWKEI----- ----------------------IVSIRKP-------------------------NG--DF RYSQHHVRRFAGLPAQ---GKSPTEELLAD------------------------------ -----------------------W-GTTNCTVGELV------------------------ ---------------------------------DMLKNNSLLAA-------VTLL----- LPGLK---DAIPA----------------------------ETLQPGP------------ ------------PSGET------------------------------------------- ---YSALPTRLLDDAGALA--G------SSS-----------ASTHILPDSR--EPEPSG --------EP----------------------FRNFRL------RSVPYNDLIRITNDFD DRPVSDG------GCRLGEGGFGAVYKGVLN--------QI--P----VAVKKLVPIEDI S---LE--ELRVQFHQEVQTL--RV--LKHENLVDMVGFSC----DGQYPCVIYPLMSNG SLLNCL-ACLE-----GSPPLSWKQRCSIAEGTANGLDYLH----------SNHHVHRDV KSANILLDEKRVAKISDFGLTRASPK--------GTS------------TTMM---TERI VGTCAYMAPEALR----GQVT------PKSDIFSFGVVLLEILS-GL-PPADENR----E P-QFLMEVTFTI-DDEDEELT-------------------------------LEGFLDK- K--M-EDVDFS--QA--ES-VYT-LACSCLQDRKNQRPLSK------------------- --------------------------QVGRGRTHSLTWS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000003907 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------D----------SSVTSATYVRNISYSLRRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDCLD---PYETWRDL----- ----------------------IVALRKP-------------------------NG--EP RYTQHHVRRFEGLVAQ---GKSVTVELLND------------------------------ -----------------------W-GTTNSTVGELV------------------------ ---------------------------------DILRSLNLLAA-------ANLL----- LPVFV---LHMNN----------------KEVLSK-E---TQQVS--------------- -------------SVKA------------------------------------------- ---EKCPPTLLLGEAPNPP--A------GSS-----------LQTQTLLDDG--GDDTGG --------CKVFSKPYFIIFGQIFLW------HFSDGG------HVFLYGELMRITRNFD DRSISDG------GSRIGAGGFGTVYKGLLD--------SR--L----VAVKKLSPMEDM P---LE--SLQLQFNQEIQTL--KV--LKHQNLVDMVGFSS----DEQHLCIVYALMANG SLLDRL-ACLD-----GSPPLSWQLRCFISEGAARGLEYLH----------SNHHVHRDV KSANILLDENYVAKISDFGLTRASAN--------RTS------------TTMM---TERI VGTRAYMAPEALR----GEVT------PKSDVFSFGVVLLEILS-GL-PPADEKQ----E P-QFLMEFRYDI-DDEDEELT-------------------------------LEDFVDK- K--M-SDWTKG--QV--ES-IYC-LASNCLHERKNRRPVIK------------------- --------------------------Q-VWEYLVGRDRKCHAE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000005326 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------NSVTSASYIRNLSYSLRRRL-------------------- ------------------------------------------------------------ ---------------------------------------SDFLD---PQDRWMEV----- ----------------------LTSIRKP-------------------------SG--EP RYSQLHVRRFEGLAAQ---GKSPTVELLVD------------------------------ -----------------------W-GTTNSTVGELV------------------------ ---------------------------------CILKSCKLLAA-------ASLL----- LPGRP---LLSTNISLSFCPHA------EQGAVSQ-E---TQETQRAS------------ ------------PAVDT------------------------------------------- ---KSRLPTRLLEETKTRAPPE------VSV-----------LPSHIPQELS-------- --------GP----------------------SRAAGF------SSFLYNELMEITGNFD DRPISDG------GSRLGEGGFGTVYKGLLH--------DR--P----VAVKKLNPMDDI S---LD--ELQVQFNQEIQAL--RV--LKHENLVDMVGFSC----DGQHPCLVYALMVNG SLLDRL-ACLE-----GSPPLSWRQRSLIAEGTARGLEYLH----------GNHHVHRDV KSANILLDENLVAKISDFGLTRASAK--------RTS------------TTMM---TERI VGTRAYMAPEALR----GEIT------PRSDVFSFGVVLLEILS-GQ-RPADEER----E P-QFLMEMRHDI-DDEDEELT-------------------------------FEDFLDK- K--M-SDWEPS--QV--ES-VYS-LAGSCLHDRKNRRPVIE------------------- --------------------------Q-VDTQILLLNLPNNPVKTR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000042842 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S----------NSVTSATYIRNLSYSIRRQL-------------------- ------------------------------------------------------------ ---------------------------------------SGILD---PQERWKEI----- ----------------------IISIRKP-------------------------NG--DF RYSQHNVRRFAGLVAQ---GKSPTEELLAD------------------------------ -----------------------W-GTSNCTVGELV------------------------ ---------------------------------DILKSHKLLAA-------AAIV----- LPGMI---QITTA------------------------------MQIAF------------ ------------NCTET------------------------------------------- ---YSALPTRLLDNKGTQT--V------PSS-----------APTQIQLDSC--DPEPTS --------EPSQRNTCF----HVSQWRECSQTYPPLGF------SSISYNDLIKITDGFN DRPVSEG------GCRLGEGGFGAVYKGVLN--------HK--L----VAVKKLIPVEDM S---LE--DLQIQFHQEIQTL--TV--LQHENLVDMVGFSC----DGQYPCVIYPLMPNG SLLDRL-ACLE-----GTPPLSWKQRCLIAEGTASGLEFVH--------R--NHHVHRDV KSANILLDEKLVAKISDFGLTRASPK--------GTS------------TTMK---TERI VGTCAYMAPEALR----GQVT------PKSDIFSFGVVLLEILS-GL-PPVDENH----N P-QFLMEVPSAI-EDEDEELT-------------------------------FEGFLDT- K--M-EDVQLG--QA--ES-VYT-LACSCLQDRKNQRPVSK------------------- --------------------------Q-SVTRLQYVHLQHLHR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_cuniculus_ENSOCUP00000003553 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------N----------KPISPSTYVRCLNVGLIRKL-------------------- ------------------------------------------------------------ ---------------------------------------SDFMD---PQEGWKKL----- ----------------------AAAIKKP-------------------------SE--DD RYNQLHIRRFEALLQT---GKSPTCELLFD------------------------------ -----------------------W-GTTNCTVGDLV------------------------ ---------------------------------DLLIQNEFFAP-------ASLL----- LPXXX---XXXXX-----------------XXXXX-X---XXXXX--------------- ------------------------------------------------------------ ---XXXXXXXXXXXXXXXX--X------XXX-----------XXXXXXXXXX--XXXXXX --------XX----------------------XXXXXF------HSFSFYELRSITNDFD ERPIARG------GNKMGEGGFGVVYKGCLR--------NT--P----VAVKKLAAMVDI S---TE--ELKQQFEQEIKVM--AX--XXXXXXXXXXXXXX----XXXXXXXXXXXXXXX XXXXXX-XXXD-----DTAPLSWHTRCNIAQGAAAGISFLH--------E--NHHIHRDI KXXXXXXXXXXXXXXXXXXXXXXXXX--------XXX-------------XXX---XXXX XXXXXXXXXXXXX----XXXX------XXXXXXXXXXVLLEIIT-GL-PAVDEHR----E P-QLLLDIKEEI---EDEEKT-------------------------------IEDYVDT- K--M-SDAEPS--SV--ES-MYS-VACQCLHEKKNKRPDIK------------------- --------------------------K-VQQLLQEMIPS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000003026 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S----------KTVTPSTYVRCLNFGLIRQL-------------------- ------------------------------------------------------------ ---------------------------------------ADFID---PQEGWKKL----- ----------------------AVDIKKP-------------------------SG--ES KYNQLHIRRFEGLIQM---GKSPTCELLFD------------------------------ -----------------------W-GTSNCTVGDLV------------------------ ---------------------------------DLLIRNQFLAP-------ASLL----- LPDAV---PKTDQ---------------TFPLPSQ-E---TLPIQ--------------- ------------------------------------------------------------ ---EKPVPPLDKEKTTTLPGMA------QNH------------EYYSFPDST--SSDTNS --------VE----------------------FSDTRF------HQFSFQELRSVTSNFD ERPISIG------GNKMGEGGFGVVYKGSIS--------NR--V----VAVKKLAAMVDI S---TQ--ELKQQFDQEIKTM--AK--CRHENLVELIGFSS----DGDDLCLVYVYMPNG SLFDRL-SCLV-----SSP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_intestinalis_ENSCINP00000015329 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MSWGWGSFQTPRKQVTAQTYIRNLPYSVLKSI-------------------- ------------------------------------------------------------ ---------------------------------------ADDLDTAGTATNWRDF----- ----------------------VLKIPRG-------------------------PNDPEP RYQLQDIRKFEMIAGR---GDSPTTAAIDA------------------------------ -----------------------W-STSNATVQDLI------------------------ ---------------------------------NVLTSLGLISM-------VNMLKSQVT MPPPYEEAVNREQTQSTLPYPQQAQYRPVPTPVGQPYQPYPNHNIHQPVYNYESHRSSHP PIPPRPSIFSDFASIRQPTRPN-------------------------------------- ---EQKSYQVSSSEKSLTRQPT--------------------ENDSALSVGNKLEEEQKS ELAFLLQGLNLNANGYYVPTVPILQQRTISKNFNKTDIYSFCSVSPYSYSSLKMLTSDFN D------------SLKLGEGAFGSVFQGHLTQPKDGDSLER--K----IAIKRLKLDTPE F---AT--AITEQFKKEVHVI--SE--LQHENILPLMGYSC----DGPELCLVYDYMFNG SLSSSLESCRL-----GKVVLLVGQRLEIAKGSSNGISYLH----------EQKLIHRDI KSSNILLDSNMKPRISDFGLIRSTST--------KTVD----------LTSTK---TTNP IGTMVYMSPEAFK----GVVS------YSMDVYSFGVVLLELLT-GL-PVLDENR----D P-SHLPMFIEE------SMEE---------------------------DETSLSMFADT- ---RAGPWSNG--VD--DS-IYE-LSSQCLDFRYKRRPTMH------------------- --------------------------K-VLSELSAMLCKTEDPQR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000014885 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSKTVTPSTYVRNLSHGMHRQL-------------------- ------------------------------------------------------------ ---------------------------------------ADLLD---PQEGWKKI----- ----------------------AVNIMKP-------------------------SG--DA RYSQFHIRRFEGTVQM---GKSPTCELLYD------------------------------ -----------------------W-GTTNCTVQDLK------------------------ ---------------------------------DLLQKNGFSAA-------ASLL----- LPAKN---TENVN----------------------------------------------- ------------------------------------------------------------ ---ASTRPVSSAINAPCEMSAA----------------EVIDTCNPHTYQSK--GPEENE -----------------------------VDDFDDMGI------GRFSFTEVKQSTNNFD IRPVSEG------GNKLGEGGFGVVFKG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000023777 --------------------------------------------M--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-----------DVTPNTPVRKLRYSALRAL-------------------- ------------------------------------------------------------ ---------------------------------------ADLLD---PQDTWRSI----- ----------------------MADISRA-------------------------CG--EP RYTQMHMRRFEACVLQ---GKSPTMELLFD------------------------------ -----------------------W-GTSDCTVGDLV------------------------ ---------------------------------EILIRHQLFAA-------VTVL----- LPDHS---VCHTH------T---------GSVWCE-E---AAPAS--------------- -------------AVCL------------------------------------------- ---QACEITQTVEDNSNKPQKI------SKPVEDDSNKPVQEQELFVEPDSS--SGAQES --------SW----------------------DSSQGF------HTFSLHELTAMTQHWD ERPLSDG------GCRLGSGGFGVVFRGRMG--------DK--H----VAVKKLNPLDGS S---YE--DLRKQFNQEIQTL--R------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000010778 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PALYIHSMPAWVLEDF-------------------- ------------------------------------------------------------ ---------------------------------------CQKMDCL-SDYDWMRF----- ----------------------ASYVITD------------------------------- ---QTELRKIKCMEKT---GISITRELMWW------------------------------ -----------------------W-GVRLATVQQLL------------------------ ---------------------------------DLLQGLQLYRA-------AQVI----- LDWTS---ASSVTSPEK--EE--------SEPP--KQ----IISVPPTEGKV----RDKE NAISLLPFPDSSHLGAV------------------------------------------- ---PAGSAVSAGALYSLPAPPP------PPR-----------DLLNSL--QS--NPPVLS SVK--PCSSS--------------TPQQETMADLLSGS------LLWTQREIANATNSFS D------------KNRICEGTFADIYKGQRN--------NM--V----FVIKRLKEAMLE CTS-PD--STQRFFHTEVQIC--FR--CCHINILQLLGFSV----ETGSHCLIYPYLPNG SLQNKL-QCHD-----DSAPLTWEMRISISLGVVRAVEYLH----------NFGILHGNI KSSNVLLDENFTPKLGHSGL----RL--HS--SDKKSE----------YAMMK---TKVL QASLTYLPEDFVRH---GQLT------EKVDIFSCGVVLAEILT-GI-KALDEDR----H P-IYLKDMIAD------EIQS-AKEGSNSKVKNL----------EKLAAKEICCKYLDR- K--A-GHLLEE--VA--VD-FAS-AICLCLR---KKNLNIA------------------- --------------------------E-VREIMEMAENKLK-EHY--------------- --------I----C-GSSTSGFSM------------------------------------ -----------------------------------------NTPEETDDETASVSVDVPS AVGS----------KEESSQAAILTSGSPCAPSTGAVAPDTYGIYMSRVPCESDESSSFM WNPPEKSTEELASHKCSNSEKAAGCDYGIKQGKPAQRLQERSLVCTRGDGILEAAAAAQG TSPQGSTDLDSSSAP--------------------------------------------- ---------------QGKGA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000358997 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWCQF----- ----------------------AALIVRD------------------------------- ---QTELRLC---ER----SGQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PAPLPSPGTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAS T----------FLSP--------------------------------------------- ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-P G--------P--------------ESSVSLLQGARPFP------FCWPLCEISRGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKENADL E---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---AR T-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAAPIAMQIYKKHLDP- R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYERLEKLQAVV-------------------- --------AGVPGHSEAAS--CIP------------------------------------ -----------------------------------------PSPQENSYVSSTGRAHSG- -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL -----------------------------------------------------------S AALRSWHL---TPSCPLD-------P-----APLR------------------------- EAGCPQGDT------AGESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------SR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL ---YEDGALDSLQLLSSSSLPGLGLEQDR-QGPEESDEFQS------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000023353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGPGEPAAPGAQHFLYEVPPWVMCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWCQF----- ----------------------AALIVRD------------------------------- ---QTELRLC---ER----SGQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAS T----------LLSP--------------------------------------------- ---AFPGSQTHAG-PELGVVPS------PAS-----------LRPPPPSPAP--SSTK-P G--------P--------------ESSVSLLQGAHPSP------FCWPLCEISQGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADL E---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QSGFYCVVYGFLPNG SLEDRL-HCRT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---AR T-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGL-AADAWAVPIAMQIYKKHLDP- R--P-GPCPPE--LG--LG-LGR-LACCCLHRRAKRRPPMT------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QENSYVSSTGSAHSG- -AAP----------WQPP--AAPSGA---------SAQAAEHLQRGPNQPVESDESLGGL -----------------------------------------------------------S AALRSWHL---TPSCPLD-------P-----APLR------------------------- EAGCPQGDM------AGESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------FR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL ---YEDGALDSLQLLSSSSLPGLGLEQDR-QGPEESDEFQS------------------- ----------------------------- >B_taurus_ENSBTAP00000021407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AALIVRD------------------------------- ---QTELRLC---ER----SGQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------RILTHLQLLRA-------RDII----- TAWHP---PAPLLPPSTTSLT-------PSSIS--AP---SEAAVPGHRKLP----SLAS T----------FLSP--------------------------------------------- ---AFPGSQTHSD-PELCPGPS------PAA-----------HQPPLPSPAP--SSTK-P S--------P--------------ESPMSLLPGAPSSS------FCWPLHEICQGTHDFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEEADL E---WT--TVKQSFQTEVQQL--SR--FRHPNIVDFAGYCA----QSGFYCLVYGFLPNG SLEDRL-HVQT----QAWPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDV KSSNVLLDERLMPKLGDFGLARLSRF--TG--ANPGQS----------SSVAR---TRTV RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVLLETLA-GQ-RAVRMHG---AQ P-KYLKDLVEE------EAEE-AGVTLKGTQTAVQGGP-AADTWAALVAAQIYKKHLDP- R--P-GPCPPQ--LG--LA-LGQ-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYQTLEELQVVV-------------------- --------AGPCLELEAAS--RSP------------------------------------ -----------------------------------------PSPQENSYVSTSGSALSR- -ASP----------WQPL--AAPLGA---------QAQATDWPQKGANQPVESDESVSDL -----------------------------------------------------------S AALHSWHL---SPSCPAGPGAPSWVP-----APFG------------------------- QAACTQGGA------ARESSCGSGPG---------------------------------- ------------------------------------------------------------ -----------LQ-----PTAVEGP-----LLGSS--MSSRPPQIVINPARRKMLQKLAL ---YEDGVLDSLQLLSSSSLPDSGQDLQDRQGPEERDEFRS------------------- ----------------------------- >C_elegans_K09B11.1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MDDSLGVSEVVMIPFMKREVLQQI-------------------- ------------------------------------------------------------ ---------------------------------------CAILD---TDNTWETI----- ----------------------APYMP--------------------------------- ---GIELRDVEGCKRYSSYNQSPSELLLRI------------------------------ -----------------------W-SSKGYSTTHLY------------------------ ---------------------------------QLFAKTKLIRL-------MRMM----- RSQVHEKYHYLENKVTNSTSRVSKQMVQPPGS---------------------------- ------------------------------------------------------------ ---QSASRLKKTEIKESSPSPA--------------------AAAASQLSRS-------- -------------------------NTDDTLRVAIEGT------LPVTYCELLEATNGFA V------------SNVIGKGGYGTVYKGELK--------GTGGI----VAVKRLHSGNDT SQNGSR--ERLRQSLTELRTL--AR--FRHDNILPIYAYSL----EGSEPCLVYQFMSNG SLEDRL-LCRK-----GSVPLTWIQRKEISIGAGRGLGFLH-------SFGKTPIIHGDI KTANILLDKHMEPKIGDFGLCRDGHV------EAEAME----------KHPLI---ASHI KGTLAYLAPEFITS---KILT------TKLDVYSFGIVLLEIAS-GQ-RAYSDSR----E T-RGLVEYCQV-----------------------------NKELAAHRKIPVREIFIDRR APPLVGDEEKS--FL--DA-LIE-VGLAGANNDRKVRPTMS------------------- --------------------------Q-IVEYLCKNSIPPVV------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000000535 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AERLLSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QILQEMGHHRA-------IHLI----- VNYGA------------------------------------------------------- ----------------A------------------------------------------- ---LN-PSEQSHQRDGFPNMLP------K--------------ETANVTTDN--VLT--P KHNEKGILFK----------------------------------SSISFQNIRDGTKNFH K------------DFLIGEGEIFEVYRAEIQ--------NR--T----YAIKLFKQEKKM Q---CK--KQWKRFLSELEVL--LL--FHHPNILELAAYFT----ENEKFCLVYPYMRNG SLSDRL-QCVG-----NTAPLSWHIRISVLLGTARAIQYLH--N-----TEPCSVICGSV SSANILLDDQFQPKLTDFGMAHFRPH-------LEHQS----------CTISV---ASSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-KVVLDDP----K H-IQLRDLLME------LMEK-------------------------RG-LDSCLSFLDK- K--V-HPCPRN--FS--AK-LFS-LAGQCATSRAKLRPSMD------------------- --------------------------E-VLTTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDENQNNHSLPHDK GLRKVGVTQKVPFECSQSEVTFLGFDRKTGSERNEDTCDRPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CKESGSPKHVA---------------------------------- ------------------------------------------------------------ -----------LSQDPGAYGTDVDPSVEAPGHSYRSRPVETSCSCEFSWNECEQYKRE-- ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000092301 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LLYNLSASVMNDF-------------------- ------------------------------------------------------------ ---------------------------------------TRVMDSL-SNSDWISF----- ----------------------ASQIISD------------------------------- ---QTELRLL---EQ----SPRRTSNLMHN------------------------------ -----------------------W-GCRNGTVGALL------------------------ ---------------------------------KILEGLQWFRA-------RDII----- LKAQL-YFPRSYLVYLFTACD-------PSIIY--LY---SRQFPQNHKEQQ----PSTV T----------FIKEHL------------------------------------------- ---PVPGNMF----PEIRPLPR------PS--------------PPPPDSVS--STISKT T--------E--------------EVFCLNPPPLSSSA------MSWPFEEIQRGTCNFS P------------CKQIGEGGFGHVYKAVMR--------NT--E----FAVKKLKEDSHL D---WN--VVKESFRTEVDKL--SQ--YRHPNIMDFVGYCI----SGQTYCVIYVYMPNG SLDDRL-RNEV----ICINALSWSQRVNVLLGTAKAIQYLH--------SCSPALIHGDI KSSNILLGDHLEPKLGDFGLARLCRN--PN--KTPGKT----------STVAQ---TATV RGTLAYLPEEYLKD---GQLG------VEIDAYSFGVVMLEVLT-GR-QALEVDS--QSK T-VFLKDLVTE------EEDD-GRSFSKAKH--------SRDLSYGQTAEHICKKHLDR- RLTA-KDAPAT--HG--SADIAR-LACQCLERRRKKRPRMT------------------- --------------------------D-VFKALQDVHSGLK-ISDRSTTINKSPVA---- --------TPEPLRSDSSSIDSLS------------------------------------ ------------------------------------HHFSKLRPQEDTYPCV-------- --------------HKPVFHTLTTTVTTESGCSVSQLNEESWASQSSGVPCESDES-QGF -----------------------------------------------------------S QYLTSHCSRSKSVSCGAQ------------------------------------------ ---------------GIESTKTDISS---------------------------------- ------------------------------------------------------------ -----------VE--------------------------KQPQNVIINPARQRLVQKMEL ---YEEGRILTSDLLSSGASLYRGMSAQTRE-PEESDEFAS------------------- ----------------------------- >G_gorilla_ENSGGOP00000000218 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGPGESAAPGAQHFLYEVPPWVMCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWXXX----- ----------------------XXXXXXX------------------------------- ---XXXXXXX---XX----XXXXXXXXXXX------------------------------ -----------------------X-XXXXXXXXXXX------------------------ ---------------------------------XXXXXXXXXXX-------XXXX----- XXXHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SLAS T----------LLSP--------------------------------------------- ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-P G--------P--------------ESSVSLLQGARPSP------FCWPLCEISRGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADL E---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLT-GQ-RAVKTHG---AR T-KYLKDLVEE------EAEE-AGVALRSTQSTLQAGV-AADAWAAPIAMQIYKKHLDP- R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYERLEKLQAVV-------------------- --------AGVPGHSEAAS--CIP------------------------------------ -----------------------------------------PSPQENSYVSSTGSAHSG- -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL -----------------------------------------------------------S AALRSWHL---TPSCPLD-------P-----APLR------------------------- EAGXPQGAT------AGESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------SR-----PTAVE------------------------------------- ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000007763 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWCQF----- ----------------------AALIVRD------------------------------- ---QTELRLC---ER----S-QRTASV-WP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------RILTHLQLLRA-------RDII----- TAWHP---PAPNKPPSTTALK-------PSSLS--AP---SEAEALSPRKLQ----SSAS T----------LLSP--------------------------------------------- ---AFPGSQTHSG-PELGPVPS------LAA-----------LRPPPASPAP--SSTK-Q S--------P--------------ESQLSLLQGAHPSP------FCWPLHEISRGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEEADL E---WT--TVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QTGCYCLVYGFLPNG SLEDRL-HFQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLMPKLGDFGLARLSRF--AG--ANPSQS----------STVAR---TRTV RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVVLESLV-GQ-RAVRTHG---AR T-KYLKDLVEE------EAEE-AGVALKSTQTAIKAGL-ATDAWAAPIATQIYKKHLDP- R--P-GPCPPE--LG--LA-LGQ-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYERLEKLQVAV-------------------- --------TGLSLEPEAAS--HSP------------------------------------ -----------------------------------------PSPQENSYVSTASSALSS- -TSL----------RPPL--AVPSGA---------PAQTTERLQKGPNQPVESDESVSSL -----------------------------------------------------------S AALHSWHL---TLSCPPA-------P-----ALLG------------------------- QAGCTQGGT------ARESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------TR-----PTAVEGSWAALRHRSHRRLLSTRPGR---------------- --------------RWCRSWPCMRMGSWTAYSCYHQAPSQA------------------- ----------------------------- >M_mulatta_ENSMMUP00000026705 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------XNRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PAPLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAS T----------LLSP--------------------------------------------- ---AFPGSQTHSG-PELGLVPS------PAS-----------LRPPPPSPAP--SSTK-P G--------P--------------ESSVSLLQGAHPSP------FCWPLCEISQGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADL E---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG SLEDRL-HCQT----QACPPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------STVAR---TRTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-AQ-RAVKTHG---AR I-KYLKDLVEE------EAEE-AGVALRSTQSTL-----AADSWAAPIAMQICKKHLDP- R--P-GPCPPE--LG--LG-LGR-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYERLEKLQAVV-------------------- --------AGVPGHLEAAS--CIP------------------------------------ -----------------------------------------PSPQENSYVSSTGGAHSG- -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGLNQPVESDESLGGL -----------------------------------------------------------S AALRSWHL---TPSCPLG-------P-----APLG------------------------- EASCPQGDT------AGESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------FR-----PTAVEGL-----VLGSSASSSSEPPQIIINPARQKMVQKLAL QGFWQWGSLPDLLSGLSSSF-GLGLEQDR-QGPEESDEFQS------------------- ----------------------------- >O_anatinus_ENSOANP00000017468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASLIVRD------------------------------- ---QTELRLH---ER----TPARTASIMWP------------------------------ -----------------------W-VNRNARVGDLI------------------------ ---------------------------------QILTDLQLLRA-------RDII----- TSCEL---PQPSARPNTNVPS-------RGRTW--AK---EGGWAFSPSPLP----ES-T S----------WPPW--------------------------------------------- ---CFPGGSLQSK-PVL--IPT------PTS-----------LHPPPPRPCP--GRTD-P SVRFLQQKEE--------------RSCFSELAGGR-AP------FRWPFPEVSQGTRNFS E------------QLKIGEGGFGCVYRATMR--------NT--E----YAVKKLKEDAEL E---WS--VVKKSFVTEVEKL--SR--FRHPNIVDFAGYCV----EGGLYCLVYVFLPNG SLEDRL-HGQR----RSLAPLSWAQRVDILVGTARAIQFLH--------RDNPSLIHGDV KSSNILLDEKLTPKLGDFGLARFSRF--TG--ASSGRS----------SSLAR---TQTV RGTLAYLPEEYVKT---GKLT------VEIDTYSFGVVLLEILT-GR-RAMESAGDGRSR A-KYLKDLVEE------EDVE-ADEPQKRNWPSTSGDISASDVRAAAVATRLYRKHLDS- V--A-GPCPEE--LA--RE-LGQ-LACRCLHRRGKRRPLMT------------------- --------------------------E-VYERLEKLQTRG-------------------- --------DQSYGQDTGRS--KGP------------------------------------ -----------------------------------------ASPQENSYMFTPHCAPEDR VSGP-----------QPL--Q--TKG---------EAYLRGHFRPRPNQPVESDESVSDA -----------------------------------------------------------C AAVGSLSL---SYTSAQS-------P-----SPPG------------------------- GPGGPTGGTPAAGSLAEPQSWGRGAP---------------------------------- ------------------------------------------------------------ -----------AAWGHNFPASVDSG------QGGSGDSLPVSHQIIINPARQKFVQKLAL ---YKDGVLDSLELLSSSSSPGLAPEPRTSKGPEESDDFQS------------------- ----------------------------- >X_tropicalis_ENSXETP00000031192 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSRGSFEEEFLYRVPSQVMYRF-------------------- ------------------------------------------------------------ ---------------------------------------FHIMDSL-EETDWKKF----- ----------------------ASMIIPD------------------------------- ---MTELRLL---EQQG--SRSRTEEVVWA------------------------------ -----------------------W-SNRNAVVGELL------------------------ ---------------------------------SILRSLNLLRA-------LDVF----- ESWRSRYVPESTQNFSQANPL-------PPPYP--YPGPESAPYFQKPQTKT----DSLQ T----------QATN--------------------------------------------- ---PSDLPQQ----LPL-PGPP------PKA-----------FICSSHSAST--GGSSDC SGSQIHSSVQ--------------ESFLPSDVRDLPRQ------FVWRFQELVDGTRNFS Q------------SLLIGEGGFGCVYKATMR--------NT--E----YAVKRLKQDSEL E---WS--TMKKSFLTEIEKL--TC--LRHPNIIDLAGYSF----QGEEYCLIYLYLPNG SLEDRL-HPQG----RF-PKLPMEQRISILQGAACGLQYLH--------NYQPSIIHGDV KSSNILLDQAFMPKLGDFGLARFSRY--T---SNAGNS----------RTLAR---TSTV KGTLAYLPEEYVKM---GKLT------FELDTYSFGVVLLENLT-GR-KAIESDS--KSH T-KYLKDLVKEEECKDEEEEE-KGASMAS----------GAEAKLARVAARICQYHLDF- R--V-WQHAKE--VT--QE-LSQ-LACRCLGRQ-KKRPNMQ------------------- --------------------------E-VFLTLKRLQEHLH-RRHLGKGHGISFTPP--- --CVSTRRGFSPIHELASSVQDLP------------------------------------ -----------------------------------------LTPEENTDKYTPCGLSVKG SVQP----------YTPA--HTQHQAKVDSLCSSFSCQSLKTFRGAQNTPVESDESFPDF -----------------------------------------------------------S GSDNSAGPSDQHILYPSG------------------------------------------ ---------------VQGSISPVLPR---------------------------------- ------------------------------------------------------------ -----------VSVQDPIP------------------PVQYQNQLAVQPRQRHYCNELSG ---------------SGSSTSGASQGRPRGRATHFEEHVAALLVL--------------- ----------------------------- >R_norvegicus_ENSRNOP00000005686 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGPCGARGTLSPHSLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CTILDSCDGPLGWRGL----- ----------------------AERLSNS------------------------------- ---WLDVRHIEKYVHQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLHEMGHQRA-------IHLI----- MNYGV------------------------------------------------------- ----------------N------------------------------------------- ---WT-PPVQTHHELRFPNLPP------NSKPVCRESDPGPL-ELANVTVDN--VLV--P EHNERVVLHK----------------------------------TPISFQSILEGTKHFH K------------DFLIGEGEIFEVYRVEIR--------NQ--T----YAVKLFKQEKTM Q---LK--KHWKRFLSELEVL--LL--FNHPHILELAAYFT----EMEKLCLVYPYMSNG TLFDRL-QCTN-----GTTPLSWHVRISVLIGIAKAIQCLH--N-----TRPCAVICGNI SSANILLDDQFQPKLTDFAAAHFRPH-------LEQQS----------STINM---TGSG RKHLWYMPEEYIRQ---GRLT------IKTDVYSFGIVIMEVLT-GC-KVVLDDP----K H-VQLRDLLME------LVEK-------------------------RG-LDSCLSFLDR- K--I-PPCPRN--FS--AK-LFS-LAGQCVATRAKLRPTMD------------------- --------------------------E-VLNTLESTQPSLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LDNVPSIPVEDDENQNNYPVPPKE ALRTDRVTQKTPFECSQSEVTFLGLDRNKGNRGSEAACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEECWCPELAE---------------------------------- ------------------------------------------------------------ -----------ASQDLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ-- ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000033769 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGPGEPVVPGAQHFLYEVPPWVMCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWCQF----- ----------------------AALIVRD------------------------------- ---QTELRLC---ER----SEQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PAPVVPPSTAAPR-------PSSIS--AG---SEAGDWSPRKLQ----SSAS T----------FLSP--------------------------------------------- ---AFPGSQTHSE-SELLQVPL------PVS-----------LGPPLPSSAP--SSTKQS S--------P--------------ESPVSGLQRAHPSP------FCWPFCEISQGTCNFS E------------ELRIGEGGFGCVYRAVMR--------NT--T----YAVKRLKEEADL E---WT--MVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGLYCLVYGFLPNG SLEDQL-HLQT----QACSPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLMPKLGDFGLARFSRF--AG--AKASQS----------STVAR---TSTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVILETLA-GQ-RAVRTQG---AK T-KYLKDLIED------EAEE-AGVTLKSTQPTLWVGV-ATDAWAAPIAAQIYKKHLDS- R--P-GPCPPQ--LG--LA-LAQ-LACCCMHRRAKKRPPMTQRQNSQHS------LLALW LYLGRCSVELSGKGLLLCWMSLRSQEQ-VYKRLEGLQAG--------------------- ----------PPWELEVAG--HGS------------------------------------ -----------------------------------------PSPQENSYMSTTGSAQSG- -DEP----------WQPL--VVTTRA---------PAQAAQQLQRSPNQPVESDESVPGL -----------------------------------------------------------S ATLHSWHL---TPGSHPS-------P-----ASFR------------------------- EASCTQGGT------TRESSVRSSPG---------------------------------- ------------------------------------------------------------ -----------FQ-----PTTMEGS-----PTGSSSLLSSEPPQIIINPARQKMVQKLAL ---YEEGVLDSLQLLSSGFFPGLDLEPEKSQGPEESDEFQS------------------- ----------------------------- >G_aculeatus_ENSGACP00000001480 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------MSAGDQRSTFLYKLPPPVLWEF-------------------- ------------------------------------------------------------ ---------------------------------------CLVMDGL-SDLDWTRFVE--- ----------------------ASEVLGD------------------------------- ---QTAVRLA---EK----RERRTDWVMNQ------------------------------ -----------------------W-CNRNGSVGELL------------------------ ---------------------------------ELLERLEMLRP-------RDVI----- LRSVP---PLPSHKQSEATPT-------LSTVRVGYT---DGDDIISPKFQSSGLSFEPY S----------------------------------------------------------- ---FILKGFQSSRSAVVQVPPM------KKE-----------EDPSPDRPLP-------- --------PP--------------FCTLTSLKLPSSGV------MCWSYEEVHAGTGGFS P------------SLQVGEGGFGVVYRASLR--------NT--D----CAVKRLKQDCLL D---WI--QLRESFQNEVDQL--SK--FRHPHIVDLLGFSE----GPETVCLIYSYMELR SLEDQL-QHKQCVCPQECVSLTWSQRVGVVKGASAALQFLHFPP-----DGHAALIHGDV KSSNILLDRHLVAKLADFGLARLAHRRPAG--RSAGQT----------ASVGK---TATV RGTLAYLPVEYVRN---GELG------TAVDVYSFGVVLLEVLT-GR-RALELGR--KSG E-TYLKDLVEE------VEENLTGSSAEA-----------------------WRKQLDH- RLIPGDAAEPP--GC--ME-LVD-LACKCLDKKRKKRPAMT------------------- --------------------------E-V------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >A_carolinensis_ENSACAP00000012253 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FLYELPASVMCHF-------------------- ------------------------------------------------------------ ---------------------------------------YEIMDAL-GREEWQRF----- ----------------------ASRIVRD------------------------------- ---QVELRLY---ER----MEAPTSKVMWA------------------------------ -----------------------W-MNRNARVSDLL------------------------ ---------------------------------QILDDLQLYRA-------HNVI----- ASCES---ACSVSSTSTSPPL-------SLCLSLF-----FSKRDKDPERKW----SPSQ T----------QESP--------------------------------------------- ---PSPGSQGAAG-APLRLGTT------PMA-----------YWQQTLCGQS--SSSSSS S-----------------------SSSRLGSSLSLTCP------FEWRLEELRQATSDFS E------------NLKIGEGGFGCVYQARLR--------NT--I----YAVKRLKEEAEL D---WS--VIKNSFVTEVEKL--YR--FRHPNIVELAGYCA----EQGNFCLVYVFLPKG SLDDHL-HRQV------GPCLTWSQRLHVAVGTSRAIQFLH--------SDSPSLIHGDV KSSNILLDAALNPRLADFGLARFSRR-----PKQGTMS----------SSLGR---TQTV QGTLAYLPPEYVRT---GTLS------TAIDVFSFGV----------------------- -----KDLLSE------EEEA-QHTPTTMT---------SSSSQAAQLGTSLYQKHMDL- Q--A-GPCPEL--LG--IM-IGR-LACQCLHPRAKRRPPMA------------------- --------------------------E-VYQELERLQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >M_domestica_ENSMODP00000037830 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MDSL-ESADWHKF----- ----------------------ASLIVQD------------------------------- ---QTELRLG---ER----FHDRTARIMWS------------------------------ -----------------------W-INRNARVADLL------------------------ ---------------------------------HILTSLQLRSG-------PGHR----- DPEPP---SLPPAAPSTCTPTPPWPPPQPKPQS--GP---KE-EGARPREAC----QSFS T----------FPSP--------------------------------------------- ---GFPSDSWPSPCPPSSPAPQ------RAA------------GPLSSNTSS--SSTK-Q G--------E--------------ENKISPVEYASPPP------FRWPLLEITQATHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--S----YAVKRLKEDAEL E---WN--TIKTSFGTEVEKL--SR--FRHPNIVDFAGYCI----QDNVYCLVYVFLPNG SLEDQL-HSQN----QNPSLLSWAQRVDILLGTARAIQFLH--------QDNPSLIHGDV KSSNILLDEKLVPKLGDFGLARFSRY--SG--AASGKS----------SSLAR---TQTV RGTLAYLPEEYVKT---GKLT------VEIDTFSFGVVLLEILT-GC-RAIETDG---AR T-KYLKDLVEE------EEEE-TLASCKGMATG--AGV-DLEARAAQIGSRLYAKYTDS- R--P-GKCPPE--LG--QE-LGR-LACRCLHRRGKRRPPMTKVQMAPGAEGGPGVRPALG ALLAVCSRALPQAPLSFLILLMPPERK-IYESLEKLQASV-------------------- --------G--PSEREAGS--RGP------------------------------------ -----------------------------------------ASPQEDSYMFTPNSAPDG- -GTPLLHSQARAWHRQPP--HSSHGS---------RAQDSKQLWNHPNQPVESDESTPGL -----------------------------------------------------------C DVLNSWNLNQNSPSVPSLPGGPGERPEAQALCSLR------------------------- QTSCQPEAA------ASGESWGKS------------------------------------ ------------------------------------------------------------ -------------------------------------DTSERPQIIINPARQRFVQKLAL ---YENGVLNSLELLSSSSSPGLGLDQGNKQGPEESDEYQS------------------- ----------------------------- >R_norvegicus_ENSRNOP00000053167 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------MDAL-EPADWCQF----- ----------------------AALIVRD------------------------------- ---QTELRLC---ER----SEQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PASVLPPSTGAPR-------PSSIS--AG---SETEDWSPRKLQ----SSAS T----------FLSP--------------------------------------------- ---AFPGSQTHSE-SELLQVPL------SDS-----------LGPPLQSSAP--SSIKQP S--------P--------------ESPVSGLQRARPSP------FCWPFCEISQGTCNFS E------------ELRIGEGGFGCVYRAVMR--------NT--T----YAVKRLKEEADL E---WT--VVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGFYCLVYGFLPNG SLEDQL-HLQT----QACSPLSWPQRLDILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLMPKLGDFGLARFSRF--AG--ANPSQS----------STVAR---TCTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVILETLA-GQ-RAVRTQG---AK T-KYLKDLIED------EAEE-VGVTLKSTQPTLWMGV-ATDAWTAPIAAQIYKKHLDS- R--P-GPCPPQ--LG--LA-LAQ-LACCCMHRRAKKRPPMTQRQNSQ-S------LLPLW LCLGRRSLELSGKGLLLCWVGLRSQEQ-VYKRLEGLQAV--------------------- ----------PPWKLEVAG--HGS------------------------------------ -----------------------------------------PSPQENSYMSTTGSAQSG- -DEP----------WQPL--VVTTRA---------PAQAAQQLQRSPNQPVESDESVPGL -----------------------------------------------------------S ATLHSWHL---TPDSHPS-------P-----VSFR------------------------- EASCTQGGT------TRESSLRSGPG---------------------------------- ------------------------------------------------------------ -----------FQ-----PTTMEGS-----SMGSSSLLSSEPPQIIINPARQKMVQKLAL ---YEEGVLDSLQLLSSGFFPGLDLEPEKRKRPEESDEFQS------------------- ----------------------------- >M_musculus_ENSMUSP00000020448 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGRCGARGALSPQLLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CGILDSCDGPLGWRGL----- ----------------------AERLSNS------------------------------- ---WLDVRHIEKYVNQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------EVLQDMGHQRA-------IHLI----- INYGV------------------------------------------------------- ----------------S------------------------------------------- ---WT-PSVQTHHELPFPSFPP------EVKHACRENDPGPL-EPANVTVDN--VLV--P EHNEKGTLQK----------------------------------TPISFQSILEGTKHFH K------------DFLIGEGEIFEVYRVDIR--------NQ--A----YAVKLFKQEKKM Q---LK--KHWKRFLSELEVL--LL--FRHPHILELAAYFT----ETEKLCLVYPYMSNG TLFDRL-QCTN-----GTTPLSWHVRISVLIGIAKAIQYLH--N-----TQPCAVICGNV SSANILLDDQLQPKLTDFAAAHFRPN-------LEQQS----------STINM---TGGG RKHLWYMPEEYIRQ---GRLS------VKTDVYSFGIVIMEVLT-GC-KVVLDDP----K H-VQLRDLLME------LMEK-------------------------RG-LDSCLSFLDR- K--I-PPCPRN--FS--AK-LFS-LAGRCVATKAKLRPTMD------------------- --------------------------E-VLSSLESTQPSLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LDNVPSIPVEDDENQNNHSVPPKE VLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------HEECWSPELVA---------------------------------- ------------------------------------------------------------ -----------PSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ-- ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000033611 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QILQEMGHHRA-------IHLI----- ANYGA------------------------------------------------------- ----------------T------------------------------------------- ---LN-PIEQSHREKEFPNMLQ------KVECVCVDNDPCKLEETANVTVDN--VLI--P ERNEKGILLK----------------------------------SSISFHSIVEGTKNFH K------------DFLIGEGEIFEVYRVEIQ--------NR--T----YAIKLFKQGGKM Q---CK--KQWKRFLSELEVL--LL--FRHPNILELAAYFT----ESEKFCLVYPYMRNG SLFDRL-QCVG-----DTAPLSWHIRIGVLIGTSKAIQYLH--N-----TELCSVICGSI SSANILLDDQFQPKLTDFAMAHFRPH-------LEPQS----------SAISM---TSSS SKHVWYMPEEYIRQ---GKLS------IKTDIYSFGIVIMEVLT-GC-KVVLDEP----K H-IQLRDLLIE------LMEK-------------------------RG-LDSCISFLDK- K--V-PPCPQN--FS--AK-LFS-LAGRCAATRAKLRPSMD------------------- --------------------------E-VLNILESTQASLY-FAEDP------------- --------PTSLKSFRSP--SPLF------------------------------------ ------------------------------------FDNVPSIPVEDDENQNNPSPPHDQ SLRKDRMTQKTPFECSQSEVTFLGFDKKTGSRGNEDSSSRSGSP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEESWSPKCAT---------------------------------- ------------------------------------------------------------ -----------PSLDLRAPSVHTDTSAEAPGHSYRSRPVETSCSSIFSWNECKLYKKASV SDEDKEESKNC------------------------------------------------- ----------------------------- >A_gambiae_AGAP002966-PA ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CMLCPIMSKP NGQHTEMEGKPSGLSAATTVAPLSNFVYIYDIPRMEKKRL-------------------- ------------------------------------------------------------ ---------------------------------------AALLE---VNNKWYEL----- -------------------------------------------------------GEKQM GYSTVELDSTQRCCQRN--NRSPAEQLLDK------------------------------ -----------------------W-GNYNHTITELF------------------------ ---------------------------------VVLSREKLYNC-------MELI----- KRYVD---SRYHVLIKESASDGRNAVANMATFSGANN----------------------- ------------------------------------------------------------ ---NANVPNGHRAAHRLKDGAA------DQKVNGGGGDGAAAAAAAATNDKS--NPTNSK ENSPFANELA----------------------DLTSLI------PKISYEELTAATDNWS E------------RNILGKGGFGTVYRGNFK--------HT--F----MAIKKIDYNKVK SSE-AERIQLQQSF-NELRFL--NS--CRHDNIVPLFGYCI-----EKEPCLVYQFMPGG SLDKSL-FARR-----PASPLTWRERMNIAIGTARGLQYLH-------TFGDKPFIHGDI KPGNILLNEYKQPRIGDFGLTRQGAV--------QDSA----------TV------VSRV YGTRPYIPKEFYDR---RELS------TKVDTYSFGVVLYEIGT-GL-RAWDERR----T E-KHLKDYIAR------AVQE----------------------------QMHVTQLADQ- ---SLPMDAEALMCC--FK-LLQ-VGRVCTADDPKQRPDMV------------------- --------------------------G-VMWQLSAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000028744 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGPGDPAAPGAQHFLYEVPPWVMCRF-------------------- ------------------------------------------------------------ ---------------------------------------YKVMDAL-EPADWCQFGGWRR AGDAGAGGARAPGAGPDACRPAAALIVRD------------------------------- ---QTELRLC---ER----SGQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------SILTHLQLLRA-------RDII----- TAWHP---PAPLLPPSTSAPR-------PSSPP--AP---CEADVPRPRKLP---TASAS T----------LPSP--------------------------------------------- ---AFPGSQTHSG-AELGPVHS------PGI-----------LQPPPPRPAP--SSTK-P S--------A--------------ESPASLLQGAHPSP------FCWPLSEISQGTHNFS D------------KLKIGEGGFGCVYRAVMR--------NT--L----YAVKRLKEGADL E---WT--TVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----ESGFYCLVYGFLPNG SLEDRL-HFQT----EACAPLSWPQRLNILLGTARAIQFLH--------QDSPSLIHGDI KSSNVLLDDRLMPKLGDFGLARLSRF--AG--ANPGQS----------STVAR---TRTV RGTLAYLPEEYVKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVRTQG---AK T-KYLKDLVEE------EAEE-AGVTLRSTQSTLQAGL-ATDAWAAPIASQICKKHLDP- R--P-GPCPPE--LG--LV-LGQ-LACCCLHRRAKRRPPMT------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QENSYVSVPSSG---- -ASP----------RQPL--AAPSGA---------PAQATEWLQKGPNQPVESDESVSGL -----------------------------------------------------------S AALCSWHM---SPSCP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000008814 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CAVLDSCDGALGWRGL----- ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLQEMGHRRA-------IHLI----- TNYGA------------------------------------------------------- ----------------V------------------------------------------- ---LS-PSEKSYQEGGFPNILF------K--------------ETANVTVDN--VLI--P EHNEKGILLK----------------------------------SSISFQNIIEGTRNFH K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKM Q---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG TLFDRL-QCVG-----DTAPLPWHIRISILIGISKAIHYLH--N-----VQPCSVICGSI SSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----K H-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- K--V-PPCPRN--FS--AK-LFC-LAGWCAATRAKLRPSMD------------------- --------------------------E-VLNTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDESQNNNLLPSDE GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEESWFPKYIV---------------------------------- ------------------------------------------------------------ -----------PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- ------------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000261233 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CAVLDSCDGALGWRGL----- ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLQEMGHRRA-------IHLI----- TNYGA------------------------------------------------------- ----------------V------------------------------------------- ---LS-PSEKSYQEGGFPNILF------K--------------ETANVTVDN--VLI--P EHNEKGILLK----------------------------------SSISFQNIIEGTRNFH K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKM Q---CK--KHWKRFLSELEVL--LL--FHHPNILELAAYFT----ETEKFCLIYPYMRNG TLFDRL-QCVG-----DTAPLPWHIRIGILIGISKAIHYLH--N-----VQPCSVICGSI SSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----K H-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- K--V-PPCPRN--FS--AK-LFC-LAGRCAATRAKLRPSMD------------------- --------------------------E-VLNTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDESQNNNLLPSDE GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEESWFPKYIV---------------------------------- ------------------------------------------------------------ -----------PSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- ------------------------------------------------------------ ----------------------------- >M_mulatta_ENSMMUP00000021862 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGNCGVRGALSAHTLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CAVLDSCDGALGWRGL----- ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLQEMGHRRA-------IHLI----- TNHGA------------------------------------------------------- ----------------V------------------------------------------- ---LS-PSEKSYQEGGFPNILL------K--------------ETASVTVDN--VLI--P EHNGKGILPK----------------------------------SSISFQNIIEGTRNFH K------------DFLIGEGEIFEVYRVEIQ--------NL--T----YAVKLFKQEKKM Q---CK--KHWKSFLSELEVL--LL--FHHPNILELTAYFT----ETEKFCLVYPYMRNG TLFDRL-QCVG-----DTAPLPWHVRISILIGISKAIHYLH--N-----VQPCSVICGSI SSANILLDDQFQPKLTDFAMAHFRSH-------VEHQS----------CTINM---TSSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----K H-IQLRDLLIE------LMEK-------------------------RG-LDSCLSFLDK- K--V-PPCPRN--FS--IK-LFC-LAGQCAATRAKLRPSMD------------------- --------------------------E-VLNTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDESQNNHLLSSDE GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------REESWFPKYIV---------------------------------- ------------------------------------------------------------ -----------PSQDLRPFKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQHKKE-- ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000016336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LTGLGPDCGHTQRPQSG----DQFLYDLPPRVLWEF-------------------- ------------------------------------------------------------ ---------------------------------------CRVMDAL-SDLDWTRF----- ----------------------ASMVLDD------------------------------- ---QTALRLA---QK----QEKRTDWVMNQ------------------------------ -----------------------W-EIRNGRVGELV------------------------ ---------------------------------NLLEGLELLRP-------RDVI----- LLKPP---PPPAPAAPPTAPA-------APRVP--SP---PFNTV----------WSKRS S----------PRPA--------------------------------------------- ---ALNVSLLVPRASTVAQQCI------DAT-----------PQPSIMYG-P--ETHQ-G C--------P--------------NFLQRGPDLITSGL------MCWSYEEVHAGTKGFS P------------TLQVGEGGFGVVYKATLS--------NT--V----CAVKVLKEDRLL D---WK--VLNQSFQTEMEKL--SK--FRHPNIVDLLGFSK----GPGTVCLIYSYMENK SLEHKL-HNGD----QQSSYLSWSQRVSVVTEASTALQFLHSPP-----SGNTPLIHGDV KSSNILLDHHMTAKLGDFGLARFAPR------PSPSET----------KPLGR---TTTI RGTLAYLPHEYVRT---GKLG------TVVDVYSFGVVLLEVLT-GR-RALEEDQ--DLG Q-KYLKDLVEE------IRESPSGSPEESWRKQLDHRL-LAVTWSRSTAAVSA------- ---E-GATEPA--GW--ME-MVA-LACRCLANNRKGRPAMA------------------- --------------------------E-VFDKLQDINTLVK-R----------------- --------SSPHMDLSGACL---S------------------------------------ -----------------------------------------KEPAQSSQSSSCSSSCSL- --------------QSPHRLRSPSSH-------VSSSSSCSPSPSSFAGPCETDESRGFS -----------------------------------------------------------H PCLQSGHLSQVGPATFWGLVKVGLKA---------------------------------- ---------------EHPSGGAACGP---------------------------------- ------------------------------------------------------------ -----------GPASASRDRYTVYLCVRACVCACVCVCA-----VLMNPSKQHLLQKKTL ---YEEGRIETPELLSSEDIYG-GTSSVALTGPEESDEQDW------------------- ----------------------------- >A_gambiae_AGAP003062-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MLSMLGSDGSTSDTLGSESSSSAIVPQ------------------------------ ---------------------------VDESVSDFI------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------KFSTSPVV------AVYAYDHLREVTDGFN VAPYTNGNLAAPNGRSLGAGGFGAVFLALNL--------AP--S----IPVAAVKRLDPD K------YKFREKFHLELDIL--SK--HSHTNVVSLLGSSS----DGPQLCLVYEYLKDG NLEAALSLVRA-----GQRQMGATVRLQYLKDIANAVAFLH---------ERAKIIHRDV KSANILLDGP-VAKLCDFGLIKRTSS--------RT--------------------TTSI IGTNAYMAPEAVR----GDVS------PALDIFAFGIVVAETVT-GE-PVLAEKE---SR SEIDLAGYVCRQRAEGRD----------------------------------LGLLVDRR A--AVGRDGEARWCEAGRK-LLE-IAIKCMGEKWS-RPNSG------------------- --------------------------A-LADAVAGIQLVPL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_pygmaeus_ENSPPYP00000005399 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLQEMGHRRA-------IHLI----- TNYGA------------------------------------------------------- ----------------V------------------------------------------- ---LS-PSEKSYQEGGFPDILF------K--------------ETANITVDN--VLI--P EHNEKGILLK----------------------------------SSISFQNIIEGTRNFH K------------DFLIGEGEIFEVYKVEIQ--------NL--T----YAVKLFKQEKKM Q---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG TLFDRL-QCVG-----DTAPLPWHIRISILIGISKAIHYLH--N-----VQPCSVICGSI SSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----K H-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- K--V-PPCPRN--FS--AK-LFC-LAGRCAATRAKLRPSMD------------------- --------------------------E-VLNTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDESQNNNLLPSDE GPRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEESWFPKYIV---------------------------------- ------------------------------------------------------------ -----------PSQDLRPYKVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEHYKKE-- ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000009429 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSSGPVPAGTALLDLPPLLLGRL-------------------- ------------------------------------------------------------ ---------------------------------------CALLDGAHGPLGWRDL----- ----------------------AERLSSN------------------------------- ---WLEVRHFEKYVQQ---GRSGTRELLWS------------------------------ -----------------------W-AQKNKTVGDLL------------------------ ---------------------------------QVLEDMGHQRA-------IDCL----- TNPGE------------------------------------------------------- ----------------S------------------------------------------- ---LNISPSQTCQRDGFQSRAS------K--------------KTADSAVGN--EVLSPP KYQHQGIRPK----------------------------------ASIDFKSIIEGTGNFH G------------DLLIGEGEFFQVYRMEFE--------NQ--T----YAIKLFKQEKTM Q---SK--KYWKPFFSELEVL--LL--FHHPNILELTAYFI----EAERFCLVYPFMRHG SLFDRL-QCLG-----NTAPLSWKVRLGVLIGVARAIQVLH--S-----AKPCSVISGSI TSTNILLDDQFQPKLTDFATVHLQPQ-------TDCRS----------FTVST---KSNA AKHLWYMPEEYLRQ---SRLS------TKTDVYSFGIIIMEVLT-GC-KVVMEEP----K H-IQLRDLLME------MMEK-------------------------RG-LDSCFSLLDK- K--V-EACPRN--FS--AK-LLT-LAGQCATSRAKSRPSMD------------------- --------------------------E-VLETLETTRPALY-FTEDP------------- --------PASLRSFRPP--SPLF------------------------------------ ------------------------------------LDLLPSVPVEDDENL----PLSGE EPNRHGVDRKTPLECSQSEVTFL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gallus_ENSGALP00000035437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASYVITD------------------------------- ---QTELRKIKCMEKT---GISITRELMWW------------------------------ -----------------------W-GVRLATVRQLL------------------------ ---------------------------------DLLQALQLYRA-------AQVI----- LDWIS---PSSISTSEK--EE-------LVEPP--KQ---ENVSLTPTENKH----KEKE NEISLLPSSDLSQPGIS------------------------------------------- ---PACNAVSEGTLYSLPSPPP------PPR-----------DLLKSL--QS--NPSVSS SVK--PCSSS--------------TPQQETMTDLPSGS------LLWTQKEVTNATDGFS G------------KNRICEGTFADVYKGQRH--------NM--V----YVIKRLKEAITE CTS-PN--STQRFFHTEVQIC--FR--CCHVNILQLLGFTV----ESELHCLIYPYLPNG SLQNKL-QHQD-----DSAPLPWEIRLSISVGLIRAVEYLH----------NFGILHGNI KSSNVLLDENFTPKLGHSGL----RL--YS--ADKKSE----------CTMMK---TKVM QASLTYLPEDFVRH---GQLT------EKVDVFGCGVVLAEILT-GI-KALDEGR----S P-IYLKDMIAD------EIQT-AKETSHSKDKNL----------EKLAAKEICCKYLDK- K--A-GHLLEE--VA--ID-FAS-ATCLCLK---KKNSNIT------------------- --------------------------E-VLEIMETAENKLR-EHY--------------- --------I----CGGGSTSGFSM------------------------------------ -----------------------------------------NTPEETDDETTNLSVDAPS AGQN----------KDDSTQPVLLASGGQCTPSVGVVPPDTYCEQMSRVPCESDESTSFI WNPEEKSTDELFSNNYNNSENITSSDCRMKERTKANGLRERNVVCIRSDDNLEMAATAHS TFQPKNADLDSASSS--------------------------------------------- ---------------QGKCR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_troglodytes_ENSPTRP00000038647 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MAGGPGP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TELRLC---ER----SGQRTASVLWP------------------------------ -----------------------W-INRNARVADLV------------------------ ---------------------------------HILTHLQLLRA-------RDII----- TAWHP---PALLPSPSTTAPR-------PSSIP--AP---AEAEAWSPRKLP----SSAS T----------LLSP--------------------------------------------- ---AFPGSQTHSG-PELGLVPS------PAS-----------LWPPPPSPAP--SSTK-P G--------P--------------ESSVSLLQGARPSP------FCWPLCEISRGTHNFS E------------ELKIGEGGFGCVYRAVMR--------NT--V----YAVKRLKEDADL E---WT--AVKQSFLTEVEQL--SR--FRHPNIVDFAGYCA----QNGFYCLVYGFLPNG SLEDRL-HCQ----------------------TARAIQFLH--------QDSPSLIHGDI KSSNVLLDERLTPKLGDFGLARFSRF--AG--SSPSQS----------SMVAR---TQTV RGTLAYLPEEYIKT---GRLA------VDTDTFSFGVVVLETLA-GQ-RAVKTHG---AR T-KYLKDLVEE------EAEE-AGVALRSTQSTLHAGL-AADAWAAPIAMQIYKKHLDP- R--P-GPCPPE--LG--LG-LGQ-LACCCLHRRAKRRPPMT------------------- --------------------------Q-VYERLEKLQAVV-------------------- --------AGVPGHSEAAS--CIP------------------------------------ -----------------------------------------PSPQENSYVSSTGSAHSG- -AAP----------WQPL--AAPSGA---------SAQAAEQLQRGPNQPVESDESLGGL -----------------------------------------------------------S AALRSWHL---TPSCPLD-------P-----APLR------------------------- EAGCPQGDT------AGESSWGSGPG---------------------------------- ------------------------------------------------------------ -----------SR-----PTAVEGL-----ALGSSASSSSEPPQIIINPARQKMVQKLAL ---YEDGALDSLQLLSSSSLP-------------ESDEFQS------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000015274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MACYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDAL-SEWDWMEF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLCRLELYRA-------AQII----- LNWKP---APEIRCPIPAFPD-------SVKPE--KP---LAASVKKAENEQ----EEGQ P----------VRMATS------------------------------------------- ---PGPGSSPARAHQPA-FLQP------PEE-----------DAPHSL--RT--DLPTSS DSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN Q------------NHKISQGTFADVYRGYRH--------GT--P----FVFKKLRETACS S---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNV KSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLF RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----S P-VYLKDLLLS------EIPS-STASPCSRKTGV----------ENVMAKEICQKYLEK- G--A-GRLPED--CA--EA-LAT-AACLCLR---KRNTSLQ------------------- --------------------------E-VRGSVAAVEEWLR-GRE--------------- --------MLLPWSGLSEGTGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSLDASS S-------------VSVAPWAGAATPLLPTENGEG------------------------- -----------------------------------------------------------R LRVIVGREADSSSEA--------------------------------------------- ---------------CVGPEPPQDV----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWQIDINEAKRKLMENILL ---YKEEKLDSIELFGP------------------------------------------- ----------------------------- >E_caballus_ENSECAP00000010808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSCYIYQLPSWVVDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDTL-SEWDWMHF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITREVLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLCHLELYRA-------AQIV----- LNWKP---APEIKSSVPYFPD-------AVNPG--RP---LAASVRDTKDGQ----EQGQ P----------TRTAAS------------------------------------------- ---PGSKSSVSRGPWPA-LLPL------PPE-----------DASSAL--NT--EPPASS DSK--DFSAS--------------IPEEETLLSLAGDS------LFWSEADVVQATDNFN Q------------NHKISEGTFADVYRGHRH--------GE--P----FVFKKLREASTS CLPVRR--SIKKFFQAEVQIC--HR--CCHPNVLPLLGFCT----GGQFHSLVHPYMANG SLQDRL-QHQG-----GSDPLLWLQRVSICSGLLRAVEHLH----------GLDIIHSNI KSSNVLLDENFTPKLAHPMA----HL--CP--VNKRSR----------YTVMK---THLF QASAAYLPDDFIRV---GQLT------KRVDVFSCGIVLAEVLT-GI-PAMDNGR----S P-VYLKDLLLS------EIPS-STTSLCSRKTDV----------EKVMAKELCQKYLEK- R--A-GRLPEG--CA--EA-LAT-AACLCLR---RRNASLA------------------- --------------------------E-VCGSVAAVEEKLR-GQD--------------- --------TSLPWSGLSEGTGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSFDGSC S-------------MRTAPSAGAAALPPPTEDGEG------------------------- -----------------------------------------------------------R PPAGGEIEADSSSEA--------------------------------------------- ---------------CASGEPPRDA----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWKIEINEAKRKLMQNILL ---YKEKKLDSIELLGL------------------------------------------- ----------------------------- >T_nigroviridis_ENSTNIP00000007783 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PGPGQTNIQLVGLPDWELFLYELPSAVYWDF-------------------- ------------------------------------------------------------ ---------------------------------------CRVMDTL-SDLDWTRF----- ----------------------ASLVLDD------------------------------- ---QTALRLA---EK----QAHAPDWVMNR------------------------------ -----------------------W-GSRNGRVRDLL------------------------ ---------------------------------HLLEGLELLRP-------RDLI----- LNGQS---SPPLRTPVTSSLR---------------PDSSPFEGVSCPDWERRWFWSRPS M----------LAHP--------------------------------------------- ---GCCSSSKGNTWSLLKVHKL------QSE-----------IQPPAPPGQP--HTQPSI A-----------------------------EASCTSGL------MCWSYEEVHAGTKEFS P------------TLQVGEGGFGVVYKATLR--------NT--V----CAVKVLKQDRLL D---WK--LLKESFRTEMEKL--SK--FRHPNIIDLLGFSE----GPGTVCLIYNYMENK SLEHKL-HNAR----QQGSCLSWSQRVGVVTGASTALQFLHCPP-----KGNAPLIHGDV KSSNILLDQHMTAKLGDFGLASLALK-----SSSPSAT----------TTLGC---TTTI RGTLAYLPMEYVRK---GELG------TVVDVYSFGVVLLEVLT-GR-RALEKDK--TSR E-RYLKDLVDE------IKESPSGSSQKTRHPAVAFPVETKPPGMPSPAVS--------- ---AGGASEPA--GW--ME-MVA-LACMCLDKNRKRRPAMA------------------- --------------------------E-VGDRLPRLPAPCP------------------- -------------PLRLAVLVKPT------------------------------------ -----------------------------------------RAEAFPSMTSSPNSGLTGQ PGDV----------SAPPPETSTAALQLPQTSQTSLLSPLKNSTAFHCSPVAPVTSLGQE GFCDQSPG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GSPRQERQRRSAASLSRCPLCALSSPWSPGPQVVLMNPIKQHFLQKKTL ---YEEGRIRTPELLSSEDIY----EGTSSGAPEESDELDY------------------- ----------------------------- >D_rerio_ENSDARP00000067130 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VESSSSSVSE RGMKHPNIITFTPGSTRNMSGNTEPSTLLFDVPPVLMESF-------------------- ------------------------------------------------------------ ---------------------------------------CRLMDSGVDGLGWRTL----- ----------------------ASRILSS------------------------------- ---QLEVRCIEMYAVA---GKSPTKELMWS------------------------------ -----------------------W-AQRNKTVEDLL------------------------ ---------------------------------KVLDEMGHARA-------RSLF----- QSQDS------------------------------------------------------- ------------------------------------------------------------ ---CVLKSSSPPHYPTYLRSTG--------------------KSCQVSDLHA--ESVSVE GEKQK---------------------------------------CFITYFDVIEGTRHFH Q------------DLKIGGSGFAEVYCGRWG--------NR--S----FAVKVFKQENKT D---WK--ALWEKFTKEIEVL--QL--NQHPNILELWGSFS----DSDRFCLVYPFLQNG SLFHRL-HEH------VDKPLSWQERLNIIKGTAKAVHHLH-------TSQPCTVICGNI TSSNILLDENMQPKLCDFGLARLRPH-------SVDQS----------CTIVM---NTAL HSNLGYLPEEYIRD---GKLS------VKLDVYSLGVVILETCT-GQ-KVKQESS----K N-LFLRDVLHS------EVEE-------------------------KGCVDACLRFLDL- ---KFEHWPPA--VA--LC-LLR-LGLECTGSKMRVRPDME------------------- --------------------------M-VLQRLIPLHPLPA-FSEDQ------------- --------PHTLDDTIPPQRPYK------------------------------------- -----------------------------------------SFPIEDDEMHSQLEELHSP RVSK----PADPCECSQSEVTFLSNEDRSFLRDCHQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ESDQRVSSSESVHSDSAARLDLYGSWPVECSCSTETEAQACADCCANGF SQSVVYVTIDDDNALPAPNDARNPAKEKMKN----------------------------- ----------------------------- >P_troglodytes_ENSPTRP00000025212 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MACYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDAL-SEWDWMEF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLCRLELYRA-------AQII----- LNWKP---APEIRCPVPAFPD-------SVKPE--KP---LAASVRKAEDEQ----EEGQ P----------VRMATF------------------------------------------- ---PGPGSSPARAHQLA-FLQP------PEE-----------DAPHSL--RS--DLPTSS DSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN Q------------NHKISQGTFADVYRGHRH--------GK--P----FVFKKLRETACS S---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNV KSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLL RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----S P-VYLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- G--A-GRLPED--CA--EA-LAT-AACLCLR---RRNTSLQ------------------- --------------------------E-VCGSVAAVEERLR-GRE--------------- --------TLLPWSGLSEGTGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSLDASS S-------------MSVAPWAGAATPLLPTENGEG------------------------- -----------------------------------------------------------R LRVIVGREADSSSEA--------------------------------------------- ---------------CVGPEPPQD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000256458 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MACYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDAL-SEWDWMEF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLCRLELYRA-------AQII----- LNWKP---APEIRCPIPAFPD-------SVKPE--KP---LAASVRKAEDEQ----EEGQ P----------VRMATF------------------------------------------- ---PGPGSSPARAHQPA-FLQP------PEE-----------DAPHSL--RS--DLPTSS DSK--DFSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN Q------------NRKISQGTFADVYRGHRH--------GK--P----FVFKKLRETACS S---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNV KSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTMMK---THLL RTSAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----S P-VYLKDLLLS------DIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- G--A-GRLPED--CA--EA-LAT-AACLCLR---RRNTSLQ------------------- --------------------------E-VCGSVAAVEERLR-GRE--------------- --------TLLPWSGLSEGTGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSLDASS S-------------MSVAPWAGAATPLLPTENGEG------------------------- -----------------------------------------------------------R LRVIVGREADSSSEA--------------------------------------------- ---------------CVGLEPPQDV----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWQIEINEAKRKLMENILL ---YKEEKVDSIELFGP------------------------------------------- ----------------------------- >D_melanogaster_FBpp0084549 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MSGVQ TAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQL-------------------- ------------------------------------------------------------ ---------------------------------------CAHLDAL---DVWQQL----- ----------------------ATAVKLY------------------------------- ---PDQVEQISSQKQR---GRSASNEFLNI------------------------------ -----------------------WGGQYNHTVQTLF------------------------ ---------------------------------ALFKKLKLHNA-------MRLI----- KDYVSEDLHKYIPRSVPTISE--------------------------------------- ------------------------------------------------------------ ---LRAAPDSSAKVNNGPPFPS---------------------SSGVSNSNNNRTSTTAT EEIPSLESLG--------------NIHISTVQRAAESL------LEIDYAELENATDGWS P------------DNRLGQGGFGDVYRGKWK--------QL--D----VAIKVMNYRSPN I---DQKMVELQQSYNELKYL--NS--IRHDNILALYGYSI----KGGKPCLVYQLMKGG SLEARL-RAHK--AQNPLPALTWQQRFSISLGTARGIYFLH-------TARGTPLIHGDI KPANILLDQCLQPKIGDFGLVREGPK----------SL----------DAVVE---VNKV FGTKIYLPPEFRNF---RQLS------TGVDVYSFGIVLLEVFT-GR-QVTDRVP--ENE TKKNLLDYVKQ--------------------------------QWRQNRMELLEKHLAA- ---PMGKELDMCMCA--IE-----AGLHCTALDPQDRPSMN------------------- --------------------------A-VLKRFEPFVTD--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000007680 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSCYIYQLPAWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDTL-SEWDWMQF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLRRLQLYRA-------AQII----- LNWKP---VPEINCSFLDFPE-------AVKPG--RP---LEASVRTMEDEQ----EKGP S----------VRPADF------------------------------------------- ---PGPGILMAKNQRASTVMKA------CAT-----------DAPHSL--KT--DVPVSS NSK--DFSTS--------------IPKQETLLSLAGDS------LFWSETDVVQATDNFN Q------------NYKISEGNFADIYKGQKH--------GT--L----FVFKKLREAAYS G---PG--SIEKFFQAEVQIC--HR--CCHPNILPLLGFCT----GNQLYILIYPYMANG SLQDRL-QDQD-----GSEPLLWPQRASICSGLLRAVEHLH----------GLGIIHGNV KSSNVLLDQNFIPKLAHPIA----HL--CS--DNKRSK----------YTMMK---THLF QASAAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----S P-VYLKDLLLG------EIPS-STTSLGCRKTGV----------EKVMAKEICRKYLEK- R--A-GRLLED--CA--ET-LAL-AACLCLR---RRNACLA------------------- --------------------------E-VCGSVAAVEERLR-GQE--------------- --------TLLPSSGLSEGTSSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSLDASY S-------------MRVAPGAGAAASFLPTEDGEG------------------------- -----------------------------------------------------------R LQVCGGMQADSSSVA--------------------------------------------- ---------------CAGPEPPQDAT---------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWKIEINEAKRKLMENILY ---YKEGKLDSIELLGP------------------------------------------- ----------------------------- >M_mulatta_ENSMMUP00000026192 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MACYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDTL-SEWDWMEF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLV------------------------ ---------------------------------DLLCHLELYRA-------AQII----- LNWKP---VPEIRCPIPAFPD-------CVKPE--RP---LAASVRKTEDEQ----EEGQ P----------VRMATF------------------------------------------- ---PGPGSSPARAHQQA-FLQP------REE-----------DAPHSL--RT--NLPTSS DSK--DYSTS--------------IPKQEKLLSLAGDS------LFWSEADVVQATDDFN Q------------NHKISQGTFADVYRGHRH--------GT--P----FVFKKLRETACS S---PG--SIERFFQAELQIC--LR--CCHPNVLPVLGFCA----ARQFHSFIYPYMANG SLQDRL-QGQG-----GSDPLPWPQRVSICSGLLCAVEYLH----------GLEIIHSNV KSSNVLLDQNLTPKLAHPMA----HL--CP--VNKRSK----------YTVMK---THLF QASVAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----S P-VYLKDLLLS------EIPS-STASLCSRKTGV----------ENVMAKEICQKYLEK- G--A-GRLPED--CA--KA-LAT-AACLCLR---KRNISLQ------------------- --------------------------E-VRGSVAAVEERLR-GWE--------------- --------TLLPWSGLSEGTGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSNLDASS S-------------ASVAPWAGPATSLLPTENGEG------------------------- -----------------------------------------------------------R LQVIMGREADSSSEA--------------------------------------------- ---------------CVGPEPPKDA----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWQIEINEAKRKLMENILL ---YKEEKLDSIELFGP------------------------------------------- ----------------------------- >M_domestica_ENSMODP00000033729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TTQYIYQLPSWVLEDF-------------------- ------------------------------------------------------------ ---------------------------------------CHKMDSL-SEWDWMQF----- ----------------------ASYVMTD------------------------------- ---QTQLRKIKSMERIQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLL------------------------ ---------------------------------DLLYRLELYRA-------AQVI----- LDWGA---IPEIASASHVLPD-------STHPG--KS---SLASLRKPEETQ----EKGL Q----------KSSGLT------------------------------------------- ---PSSSSGPSGCSNRVLQLPF------IED-----------DLPHSL--KT--N-PSTS DIK--NCHAY--------------ITQHQPLLSLNGES------LYWTEMEVIKATNGFG Q------------ENKISQGTFADVYKGQRH--------NI--T----YVFKKLQKASTR C---PRNLSVESFFHMEVQIC--LR--CSHQNILPLLGFCT----GEVFHSVIHPYMPNG SLEDRL-RCQD-----NTDPLSWEQRISISLGFLGAIEYLH----------GLKIIHGNI KSSNVLLERNFIPKLGHPRV----RV--SS--NDKKSS----------YTMMN---TQLF QAVAAYVPEDFLRV---GQLT------ERVDIFSCGIVLAEILT-SI-PAMDKER----T P-VFLKDLLIS------EIPS-PKTLLCSKNKCV----------EKLAAKEICQKYQDA- K--A-GYLPEN--CA--VD-FAT-AVYLCLQ---KKTPNLT------------------- --------------------------Q-VCAIVAELNRQIR-NPQ--------------- --------SLLSPSGNSELKNSSV------------------------------------ -----------------------------------------NTPEETDD-VDNVSVEGSS SDEP----------DKNGLWAGAGSSSPQPGYREG------------------------- -----------------------------------------------------------R CLTNG-IEADSSVGP--------------------------------------------- -----------------GPSHPQDA----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWEVEVNDAKKKLMENILL ---YEEEKLNSKELFGS------------------------------------------- ----------------------------- >A_aegypti_AAEL007642-PA ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MT PYTRSTEVRKVFELDELASVLEDDWRTLFYLIPRKIADVERPAGSYPIRYNGTH------ ------------------------------------------------------------ ---------------------------------------ESELDDYGRIQNTARARILLE EWGTSGRKGERPTLGHLYTLVDKGGMIRAVRHIEKLLKVPESAQPDSGPAAPIDVDLELN RLIEKQLEGIAYPSSTALQNGDISITQVNN------------------------------ -----------------------LDYNLPAKRDDVV------------------------ ------------------------NPPNTVPDSIIEGSLPLLSRSDNNDQSIGAVPMLSD LLNADGQDTEASTSDNDSTPRQTIEGNTLSSTSDSTSESSSNSTPTESLSRILPMVLPTI PEAGEVPN---------------------------------------------------- ---LSIFGPAASEASMDVGIPAISALMASSDSQQIVNDVSRSTETFQSEEHSSESSSSDS TEQQSSNNEP--------------VCASNLMAFSSTNVATVEPLINFSFDSLTTATGNFD IKRFSNGNPLQPDGRVLGIGGFGEVFLALNL--------TP--T----YPVSAVKRLFPT N------YKYKEKFDRERELL--SK--YNHSNIVELIGFS-----ENVTLCLVYEYLPDG TLGAALDKSRK-----GQLHLTVTRRISYLFGIAAALEYLH--------SPLVQVVHRDV TLANILLHGD-VAKLCDFGLVKRIDS--------IT--------------------ATEV SGTGPYISPEAMR----GTVT------PALDVYSYGVVLAEMVT-GE-EVLCEVL----- -PEGVGDLIERVTARGAD----------------------------------LESMVDR- ---KVSQHELSEWLTYGKE-LLK-LSNWCLRERFK-RPSAA------------------- --------------------------A-VRECVQKMKQGIC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >T_guttata_ENSTGUP00000014323 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -TS-PD--STQRFFHTEVQIC--FR--CCHINILQLLGFSV----ETGSHCLIYPYLPNG SLQNKL-QCHD-----DSAPLTWEMRISISLGVVRAVDYLH----------NFGILHGNI KSSNVLLDENFTPKLGHSGL----RL--HS--SDKKSE----------YAMMK---TKVL QASLTYLPEDFVRH---GQLT------EKVDIFSCGVVLAEILT-GI-KALDEDR----H P-IYLKDMIAD------EIQS-AKEGSNSKVKNL----------EKLAAKEICCKYLDR- K--A-GHLLEE--VA--VD-FAS-AICLCLR---KKNLNIA------------------- --------------------------E-VREIMEMAENKLK-EHY--------------- --------I----C-GSSTSGFSM------------------------------------ -----------------------------------------NTPEETDDETASVSVDVPS AVGT-------------------------------------------------------- ----------------------ASC--GILQKNPP-----RNYLATR------------Q PLPQGSTDLDFSSAP--------------------------------------------- ---------------QGKGAPLS------------------------------------- ------------------------------------------------------------ -----------RET---------------------------SWKIQINDQKKKLMENILL ---YEEDKLNSSELFES------------------------------------------- ----------------------------- >B_taurus_ENSBTAP00000008135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MSCYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNMDTL-SEWDWMQF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERAQ--GVSITRELLWW------------------------------ -----------------------W-GMRQATVQQLL------------------------ ---------------------------------DLLCHLELYRA-------AQII----- LNWKP---VLEVKSSIPDFSD-------TVKPG--KP---LAASVRNTEDKQ----ETGQ P----------VRPPTF------------------------------------------- ---PGSGPAAVRV-----NLPA------PPE-----------DASSSL--KT--NQTASA DSK--DFSAS--------------IPKQETLSSLAGDD------LFWSEVDVIQATDNFN P------------SHKISEGTFADVYRGHKR--------GT--P----FIFKKLREMACS G---PG--SVEKFFQAEVQIC--RR--CCHPNVLPLLGCCT----GEQFYSLIYPYMANG SLQDRL-QGQG-----GSDPLPWPQRISICSGLLHAVEHLH----------SLEIIHGNV KSSNVLLDQNFTPKLAHSMA----HP--CP--VNRTSK----------YTMMK---THLF QASTAYLPEDFIRV---GQLT------KRVDIFSCGIVLAEVLT-GI-PAMDNNR----N P-VYLKDLLLH------EIPS-STISLCSRKMGV----------EKEMAKEICQKYLEK- R--A-GRLPEA--HA--EA-LVM-AACLCLR---RRNASLA------------------- --------------------------E-VCSSVAAVEEQLR-GQE--------------- --------TSLPCSGLSEGTGSSF------------------------------------ -----------------------------------------NTPEETDD-VDNSSFDGSY S-------------MRAAPWAGATSSPPLTADEEG------------------------- -----------------------------------------------------------M LLAGGAVEADSSAEA--------------------------------------------- ---------------CAPPEPPQDA----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWKIEINEAKRKLMENILL ---YKEEKLDSIELFGP------------------------------------------- ----------------------------- >M_musculus_ENSMUSP00000055073 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MACYIYQLPSWVLDDL-------------------- ------------------------------------------------------------ ---------------------------------------CRNIDTL-SEWDWMQF----- ----------------------ASYVITD------------------------------- ---LTQLRKIKSMERVQ--GVSITRELLWW------------------------------ -----------------------W-SMRQATVQQLV------------------------ ---------------------------------DLLCHLELYRA-------AQIV----- LSWKP---VPESTSPLPAFPE-------AVKPG---A---VATSRRNLKDEQ----EKVR P----------VKPRSL------------------------------------------- ---LDTGPIMAGAQRQ----RP------CEM-----------DAPCSL--KT--DAPDSP QSKYCSTSTS--------------APKQERLLGLPGDR------LFWSEADVVQATEDFD Q------------SHRISEGTFADIYQGQRN--------GV--A----FAFKKLREVAGS S---PG--SMDRFLQAEMQLC--LR--CCHANVLPLLGFCT----GRQFHSLIYPYMANG SLHDRL-WAQG-----NSDMLPWPQRASICSGLLLAVEHLH----------SLDIIHSNV KSANVLLDQHLNPKLAHPVA----HP--HP--DNKKTK----------YTVMR---THLF QASAAYLPEHFIRV---GQLT------KQVDIFSCGIVLAEVLT-GI-PAMDKDR----S P-VYLKDLLLS------EIPN-STSSVCSRKTSM----------GKAVVKEICQRHVEK- R--A-GLLPEA--CE--EA-WAT-AVSVCLR---RRNASVE------------------- --------------------------E-ARVSLAGVEEQLR-GQL--------------- --------S-LPWSRVSEATGSSS------------------------------------ -----------------------------------------NTPEETDD-VDNSSLSVPS L-------------VMMASCPGAASSPLFTGHGAA------------------------- -----------------------------------------------------------Q PSTSGRQEADSSSEA--------------------------------------------- ---------------CTGPQTPQNA----------------------------------- ------------------------------------------------------------ -----------TET---------------------------SWKIEINEAKRRLMENIVL ---YKEERLDSSELFGP------------------------------------------- ----------------------------- >A_carolinensis_ENSACAP00000014667 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------C--YR--CHHPNILQLLGFSV----ESVSPCLIYPYMPNG SLMDRL-QCQG-----GSESLTWTQRIKISLGLIQAIQHLH----------RFGILHGNV KSSNVLLDADFVPQLGHSGL----RL--HP--IEKKTD----------RAMMK---TKVL QVSLAYFPEDFVRH---GQLT------EKVDIFGCGIVLAEILT-GM-KAMDEER----Y P-VFLKDVLLE------EIQA-AKKLSSSKERTF----------EQVAAMEIYHKYQDK- Q--A-AGLPET--AG--VH-LAM-AACVCLR---KKNADLA------------------- --------------------------E-V------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >G_gorilla_ENSGGOP00000006760 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAGNCGARGALSAHTLLFDLPPALLGEL-------------------- ------------------------------------------------------------ ---------------------------------------CAVLDSCDGALGWRGL----- ----------------------AERLSSS------------------------------- ---WLDVRHIEKYVDQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QVLQEMGHRRA-------IHLI----- TNYGA------------------------------------------------------- ----------------V------------------------------------------- ---LS-PSEKSYQEGGFPNILF------K--------------XXXXXXXXX--XXX--X XXXXXXXXXX----------------------------------XXXXXXXXXXXXXXXX X------------XXXXXXXXXXXXXXXXXX--------XX--X----XXXXXXXXEKKM Q---CK--KHWKRFLSELEVL--LL--FRHPNILELAAYFT----ETEKFCLVYPYMRNG TLFDRL-QCVG-----DTAPLPWHIRISILIEISKAIHYLH--N-----VQPCSVICGSI SSANILLDDQFQPKLTDFAMAHFRSH-------LEHQS----------CTINM---TSSS SKHLWYMPEEYIRQ---GKLS------IKTDVYSFGIVIMEVLT-GC-RVVLDDP----K H-IQLRDLLRE------LMEK-------------------------RG-LDSCLSFLDK- K--V-PPCPRN--FS--AK-LFC-LAGXCAATRAKLRPSMD------------------- --------------------------E-VLNTLESTQASLY-FAEDP------------- --------PTSLKSFRCP--SPLF------------------------------------ ------------------------------------LENVPSIPVEDDESQNNNLLPSDE GLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CEESWFPKYIV---------------------------------- ------------------------------------------------------------ -----------PSQDLRPYEVNMDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE-- ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000025500 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDPNTFLYDVPPVVIERL-------------------- ------------------------------------------------------------ ---------------------------------------CQILDSGVDRLGWRAL----- ----------------------AVRVVPS------------------------------- ---SLEVRMLERVEAA---GRSPTSELLWS------------------------------ -----------------------W-AQENPRLLDLV------------------------ ---------------------------------KLLQEMGHQRA-------LQLL----- QGPGS------------------------------------------------------- ------------------------------------------------------------ ---SSSSSTSGPAIRTWSNSTS---------------------LPAHSALHL--PMTSAE ENKP----------------------------------------PVITFQDIIDGTRNFH L------------EMRISEGHFCDVYRAQIG--------SE--K----VAVKLFKQTNMA S---WK--KLWDVFRKEMEIH--HM--YQHPNILDLLCCFT----DAGRYCLVYPYLADG SLFHRL-HHQ------DREPLSWQQRLTIIKGTAKALHHLH-------TAQPCPVICGSI SSANILLGSNLQPKLSSFGIARLRPH-------SANQN----------STVTL---DTRS HSNLGYLSEEYIRD---GKLS------FSLDVYGFGMVIMETVT-GR-KVTGEVS----K K-TPLRDLLVT------EVED-------------------------SGGVDSCLQFLDE- T--A-GCWPTA--VA--LD-LLR-LALDCTASRHRSRPSMQ------------------- --------------------------K-VLLALSKLLPPPSCLIADQ------------- --------PHSLDDPCDSKPSPPL------------------------------------ -----------------------------------------SIPVEHDEQLSPHASPTRA RLG----------ECSQSELTYLSDAGGAV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------DLYSSWPVQCSCPAESGGLACEDCRANGF T----------------------------------------------------------- ----------------------------- >T_guttata_ENSTGUP00000011997 ------------------------------------------------------------ -----------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTDTVA------SSSSSSLS VAPSSLSVYQNPADMSRNNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------REKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPPEEASLGETTPAS GSYPSV--PPSDSVGPPILP--SPS------P-----SKSIPIP-------QPL------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQSL-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSAAGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------QQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGGFP----V-H--------------- ----------------------------- >O_anatinus_ENSOANP00000021129 ------------------------------------------------------------ ----------------------KVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLS VAPSSLSVFQNPTDAARGNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLGETTLTS GSSPSA--TPSDSIGPPIVA--SPS------P-----SKSIPIP-------QSF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGL-RGDGE--------------------------------------L ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGGFP----V-H--------------- ----------------------------- >G_gallus_ENSGALP00000020950 ------------------------------------------------------------ -----------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTDTVA------SSSSSSLS VAPSSLSVYQNPTDMSRNNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPISQEETTLGETTPAS GSYPSV--PPSDSVGPPILP--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGV-RGEGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTAGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGGFP----V-H--------------- ----------------------------- >B_taurus_ENSBTAP00000029006 ------------------------------------------------------------ ------------------------------------------------------------ ---AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLS VLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETTLPC GSSPSA--PPSDSIGPPILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGF-RSDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTTGLSATPPASLPGSLS------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGEFA----AFK--------------- ----------------------------- >E_caballus_ENSECAP00000003689 ------------------------------------------------------------ -----------------------VWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASTDTVT------SSSSSSLS VLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVSQEEASLAETALTS GSSPSA--PPSDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGF-RSDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGAFP----V-H--------------- ----------------------------- >X_tropicalis_ENSXETP00000003054 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MWS------------------------------ -----------------------W-GQKLPTLQKLV------------------------ ---------------------------------ERLQKLEMYRA-------LGIL----- QQWSP---LSVIASKV---PE-------RRKAE--KE---SDLKTDNKLPEL----TYTS P----------LELPTP------------------------------------------- ---PLPAP------------PP------PPS-----------DLLHSLSIQS--ECSLTC HSP--EEVLS--------------IPQQEKSSFSKGLC------KIWTQKDVEDATDCFC S------------SKIIHEGEFADVYMGHKQ--------DK--L----YAIKRLKKVQDE E---QK--RMSSFFHTEAQIS--FR--CCHANILPLLGFCV----EGDCSCLINQFIRNG SLDLAL-Q-QS-----GNHILNWERRLKIALGFLKAIRHLH----------SNDILHGNI KSSNIFLDENSFPKLGHSGL----RF--CP---DKQAG----------YTKAK---SKDL QVHQPYLPDSFFRH---GQLT------VQTDIFSCGVVLAEILT-GQ-KACDKSR----N P-VYLKDLFLE------ELER-AKEYLDSDGKQA-----DHESPESLCSHQISRKYIDS- R--A-GFLSNN--AA--FQ-LSL-AACLCLT---KKRPLLQ------------------- --------------------------E-IYTWVEKADQCSR-DSQ--------------- --------NL------------SL------------------------------------ -----------------------------------------NVPEESDF-DDSLSLEPME G--A----------ISKMPCTSTQGSWSMDDHNQRNHYPKTENRDVDRTPCESDDSTLYV -----------------------------------------------------------L PTQRSRHLVGAASAI--------------------------------------------- ---------------CDHQPTQSDAL---------------------------------- ------------------------------------------------------------ -----------EQTEAVHGNVQFSWQKSREYSDQSADSSSPSWGIIVNKEKEKLLQNFDL ---YRDNKLDSGSLFDSI------------------------------------------ ----------------------------- >H_sapiens_ENSP00000288602 ---MAALSGG-------------------GGGGAEPGQALFNGDMEPEAGAGAG------ ---------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASMDTVT------SSSSSSLS VLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTS GSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGF-RGDG---------------------------------------- ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGAFP----V-H--------------- ----------------------------- >P_troglodytes_ENSPTRP00000033866 ---MAALSGG-------------------GGGGAEPGQALFNGDMEPEAGAGAG------ ---------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESLGNGTDF--SVSSSASMDTVT------SSSSSSLS VLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTS GSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGF-RGDG---------------------------------------- ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGAFP----V-H--------------- ----------------------------- >C_familiaris_ENSCAFP00000005841 ------------------------------------------------------------ ----------------------QVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESL---------------------------------- -------VFQNPTDISRSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASIAETALTS GSSPSA--PPSDSPGPPILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNIDKFE---------LFPQ VELEKQKDLIRDQGF-RSDGAPLNHLMRCLRKCQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGAFP---------------------- ----------------------------- >P_pygmaeus_ENSPPYP00000020265 ---MAALSGG-------------------GGGGAEPGQSLFNGDMEPE--AGAG------ ---------AAASSAADPAIPEEVWN-I-RQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQFLESLGNGTDF--SVSSSASMDTVT------SSSSSSLS VLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPIPQEEASLAETALTS GSSPSA--PASDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGF-RGDG---------------------------------------- ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSS-----------------EDRNRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGAFP----V-H--------------- ----------------------------- >M_musculus_ENSMUSP00000002487 ---MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPE--AGAG------ ---------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESL---------------------------------- -------VFQTPTDASRNNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVPQEEASFPETALPS GSS-SA--PPSDSTGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID--E---------KFPE VELQDQRDLIRDQGF-RGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERKSSS----- -----SSSS-----------------EDRSRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGEFA----AFK--------------- ----------------------------- >R_norvegicus_ENSRNOP00000014604 ---MAALSGGGGSSSGGGGGGGGGGGGG-GGGGAEQGQALFNGDMEPE--AGAG------ ---------AAASSAADPAIPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLESL---------------------------------- -------VFQTPTDVSRNNPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHHPVPQEEAFSAETTLPS GCS-SA--PPSDSIGPQILT--SPS------P-----SKSIPIP-------QPF------ RPADEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID--E---------KFPE VELQDQRDLIRDQGF-RGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFR ---GSTTGLSATPPASLPGSLT------NVKALQ-------KSP-GPQRERK--S----- -----SSSSS--------------STEDRSRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGGF----------------------- ----------------------------- >A_carolinensis_ENSACAP00000011088 --------------------------------------SLFNGDMEPE----LP------ ---------PLPAAGGDPAVPEEVWN-I-KQMIKLTQEHIEALLDKFGGEHN--PPSIYL EAKAYEEYTSKLDALQQREQQLLESMGNGTDF--SVSSSASTETVA------SSSSSSLS VAPSSLSVYQNPTDLSRNNPKSPQKPTVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------VTVRESLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLFVSKFFEHRPISQEETSLGESTTAC GSYSSV--VPSDLSGSTVLP--SPS------P-----SKSIPIP-------QPF------ RQGDEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGL-RGEG---------------------------------------- ---GSTTGLSATPPASLPGSLT--------KALQ-------KSP-GPQRERK--S----- -----SSSS-----------------DDRTRMKTLGRR------DSSDDWEIPDGQITV- -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDVARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDKNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMAECLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGGFS----V-S--------------- ----------------------------- >T_nigroviridis_ENSTNIP00000000196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RGGGTIRVYLPNKQRTV--------------------- -----VNVRQG------------------------------------------------- ---------------------------------------QTVHESLDKALKVRGLS---- --QECC----------------AVFRLL---E-----------------------GRKRL TDWDTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF RCQTCGYKFHQHCSSKVPTVCLDMDTVS-----K----R--FFPISSS------------ H-IQSY--FKHSPSQSN--L--TPE------P-AGMD-LSPAPA-------FHF------ --PVPGGDGQSLQRHRSTSTP---------NVHMVSTVGVAGASFIE------------- -------EVRKSNNVI---GPE-------------------------------------- ---PSPKLSTSPTSSLGSPGRR--------P--I-------KSP-SENKERK--P----- ------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVAI- -------------QKRIGTGSFGTVFKGKWH---------GD------VAVKILKVTEPT P-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS SLYRHL-HVT-------ETKFDTMRRIDVARQTSQGMDYLH----------AKNIIHRDL KSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------KQ------VEQP SGSILWMAPEVIRMQDSNPYT------FQSDVYAYGVVLFELMS-GS-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLYST--SP--KS-MKR-LIVDCLKFKRDERPLFP------------------- --------------------------Q-ILVAIEQVQDLLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIEQSRSEPSLHRAV-HAEDLNPLLF-HTTRL---------------- ---------------------------LP---------------L--------------- ----------------------------- >T_rubripes_ENSTRUP00000004441 ---EEALC---------------------------------------------------- ----------------------GNWRTV-FYAFVRKSYCF-------------------- ----------------------------------------------------DCKTYIYP L------LNVDSQRETSPEDIPRGGGTIRVYLPNKQRTV--------------------- -----VNVRQG------------------------------------------------- ---------------------------------------QTVHESLDKALKVRGLN---- --QDCC----------------AVFRLL---E-----------------------GRKRL TDWDTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF RCQTCGYKFHQHCSSKVPTVCLDMGTAK-----RILICHYDSSVGVDE------------ YPQILL--SENSPSQSN--L--TPE------P-AGRMDLSPTPA-------FHF------ --PMPGGDGQSLQRHRSTSTP---------NVHMVSTVGPAGASIIE------------- -------L-----NVSFCCSYC-------------------------------------- ---IHTLTMVGPPSSFGSPGRR--------P--P-------KSP-SEQKERK--P----- ------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVTI- -------------QKRIGTGSFGTVFKGKWH---------GD------VAVKILKVTEPT P-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDL KSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------KQ------VEQP SGSILWMAPEVIRMQDSNPYT------FQSDVYAYGVVLFELMS-GS-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-TKIFST--SP--KS-MKR-LIVDCLKFKRDERPLFP------------------- --------------------------Q-ILVAIEQVQDLLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIEQSRSEPSLHRAV-NAEDLNPLLF-HTTRL---------------- ---------------------------LP---------------L--------------- ----------------------------- >D_melanogaster_FBpp0079568 ---MNKYS---------------------------------------------------- ---------AFIV--------CISLV----LLFTKKDV------------GSHNVDS--- ---------RIYGFQQ---------SSGICHIYNGTICRDVLSNAHVFVSPNLTMNDLEE RLKAAYGVIKESKDMNANCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKNVS IRRKRTKSKDIKN-----------ISIFKKKSTIYEDVFSTDISSK-------------- ---------------------------------------YPPTRESENLKRICREECELL ENELCQ----------------KEYAIAKRHPVIGM-VGVEDCQKLPQHKDCLSLGITIE VDKTENCYWED--------GSTY--RGVANV----------------------------- --------------SASGKPCLRWSWLM-----KEI------------------------ SDFPEL--IGQNYCRNPGSV--ENS------P-WCFVDSSRERI-------IEL------ CDIPKCADKIWI-AIVGTTAAIILIFIIIFAIILFKRRTIMHYGM--------------- -------RNIHNINTPS------------------------------------------- ---ADKNIYGNSQLN--------------------------NAQDAG-------RGNLGN LSDHVALNSK--------------L-----IE----RN------TLLRINHFTLQDVEF- -------------LEELGEGAFGKVYKGQLL---------QPNKTTITVAIKALKENA-S V-------KTQQDFKREIELI--SD--LKHQNIVCILGVVL----NKEPYCMLFEYMANG DLHEFL-ISNS---PTEGKSLSQLEFLQIALQISEGMQYLS----------AHHYVHRDL AARNCLVNEGLVVKISDFGLSRDIYS--------SDYY----------RV------QSKS LLPVRWMPSESILY---GKFT------TESDVWSFGVVLWEIYSYGM-QPYYGFS----N Q-EVINLI--------------------------------------------RSRQLLS- A-------PEN--CP--TA-VYS-LMIECWHEQSVKRPTFT------------------- --------------------------D-ISNRL----KTWH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EGHFKASNP----------E---------------------------- --------------------------------------------M--------------- ----------------------------- >O_latipes_ENSORLP00000020929 ---MSS------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T S------SSYSSSGETSPEDVPRGGGTIRVYLPNKQRTV--------------------- -----VNVRQG------------------------------------------------- ---------------------------------------QTVYESLDKALKVRGLS---- --QDCC----------------AVFRLL---E-----------------------GRKRL TDWNTDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF RCQTCGYKFHQHCSSKVPTVCLDMDTVS-----K----RCDSNSCTED------------ FPVIVL--PESSPSQRNLAL--TPE------P-SGMDLLSPPST-------FHF------ --PVSGGEGQSLQRHRSTSTP---------NVHMVSTVDLASVSIIE------------- -------EALKFNTIV---GPE-------------------------------------- ---PSPKPSTSPPSFLGSPGKK--------P--P-------KSP-SEHKERK--P----- ------SSS-----------------DDKKKVHRGN-R------DSSYYWEVHSREVQI- -------------QKRIGTGSFGTVYKGKWH---------GD------VAIKILKVKEPT P-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS SLYRHL-HVS-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDL KSNNIFLHEGWTVKIGDFGLATVKAR--------WSGS----------QQ------VEQP SGSILWMAPEVIRMQDNNPYT------FQSDVYAYGVVLFELMS-GT-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLYST--SP--KS-MKR-LIVDCLKFKRDERPLFP------------------- --------------------------Q-ILVSIEQVQDLLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIERSRSEPSLHRAV-HAEDLNPLLF-QTTRL---------------- ---------------------------M-------------------------------- ----------------------------- >O_cuniculus_ENSOCUP00000012185 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGAPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---GSPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSMELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >G_aculeatus_ENSGACP00000000078 ---MEHLQ---------------------------------------------------- ----------------------GAWKTL-SNGFGMKDTAF-------------------- ----------------------------------------------------EGP-CLSP TLVQGFSCQRRSSDDGKMPD-SKTSSTIRVYLPNQQRTV--------------------- -----VNVRPG------------------------------------------------- ---------------------------------------MTLYSCLIKALKVRGLQ---- --PQCC----------------AVFRLH---P-----------------------GQRRS PPMCVESEATS--------DHSCKEEPLCNT--STLSFILKPADVLAFLSPCLYINLSDD LTLTPFYGF---CMLRIVAYLVIIGGNP-----RMSVG---CVRRPGD------------ SGASSL--RPLTSRRMRESL--TRF------P-REMHFICCGSP-------DNV------ SEPLAVGGGKQPIRLRKHREP---------NTSTVSSTLLLHASHLQ------------- -------DAMRDHDSG-------------------------------------------- ---------GSSPSQ-SPTGWS--------Q--S-------KAPAPAQRERA--P----- -----SFNN-----------------HEKNKIRPRDKR------DSSYYWEIEASEVHL- -------------SSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----E-DNLAIVTQWCEGS SLYKHL-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HQ------VEQP SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFEILT-GE-LPYSLIA----T RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP------------------- --------------------------Q-ILSSIELLQHALP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSTSEPSLHRAA-HTEDINICTL-TSTRL---------------- ---------------------------PC---------------F--------------- ----------------------------- >A_carolinensis_ENSACAP00000011023 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KSLGYR------DSSYYWEVSPKEVTM- -------------QKRIGTGSFGTVFKGRWY---------GD------VAIKILKVTNPT S-------EQVQAFKNEMQVL--RK--TRHVNILLFMGFMT----H-PSFAIITQWCDGS SLYQHL-HVQ-------ETPLEMVQRIDVARQTAQGMDYLH----------AKHIIHRDL KSNNIFLHEGLTVKIGDFGLATVKTR--------WSGA----------QQ------VEQP GGSILWMSPEVIRMQDPNPYS------FQSDVYSYGVVLYELLS-GS-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--V-SKVPSN--CP--KA-MRR-LMCDCLKFKREERPLFP------------------- --------------------------Q-ILASIESLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RIERSASEPALHR----------------------------------- ------------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000013831 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGLKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLQEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTASD------------ SGVPAP--PSFTMRRMRESV--SRM------PASSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SRLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >H_sapiens_ENSP00000251849 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >M_mulatta_ENSMMUP00000009777 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >P_pygmaeus_ENSPPYP00000014975 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >E_caballus_ENSECAP00000010011 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDAVF-------------------- ----------------------------------------------------DGPSCISP TIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHT---------------------------------------------- --------LSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >M_musculus_ENSMUSP00000108571 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGLKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLQEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTVGD------------ SGVPAP--PSFPMRRMRESV--SRM------PASSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLHVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQLQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDDNPFS------FQSDVYSYGIVLYELMA-GE-LPYAHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SRLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >C_familiaris_ENSCAFP00000007376 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDTVF-------------------- ----------------------------------------------------DGPSCISP TIVQPFGFQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NSSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >O_latipes_ENSORLP00000012350 ------------------------------------------------------------ ----------------------QIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLEAMGNGGDF-CSPSPVPALLEVKMGSLGVGGGVQSFA SAPNSLAVLQTPTDAVRGNPRSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------MTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFSHEEVSSEGTTPVS EVCPHL--PLTDSTGSICHP--TLS------P-----SKSIPIP-------PSY------ RPNEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGLQRSDGVTTEQMSECQRTSADKSPAFMSLTHLIHLLLHHHPP---S ---GSTTGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----- -----SSSS-----------------EDRNKMKPLGRR------DSSDDWEIPEGQITL- -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTDPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GS-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYDGFQ---MGVH--------------- ----------------------------- >B_taurus_ENSBTAP00000005930 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDTVF-------------------- ----------------------------------------------------DGTSCISP TIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTVGD------------ GGVPAL--PSLTMRRMRESV--SRI------PPGSQHRYSTPHA-------FTF------ SASSPSSEGSLSQRQRSTSTP---------NVHMVSATLPVDSRMIENNSLNASPRAWSR RFCVRGRDAIRSHSES-------------------------------------------- ---GSPSALSSSPNNLSPTGWS--------Q--P-------KTPAPAQRERA--P----- -----GSST-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQCQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >M_domestica_ENSMODP00000007826 ---MEHFQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDSVF-------------------- ----------------------------------------------------DGSGCISP TLVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKTR LDWNTDAASLV--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSNVGD------------ SGVPAL--PPLTMRRMRESV--SQI------PISSQHRYSTPHA-------FTF------ STSPPSSEGSLSQRQRSTSTP---------NVHMVSTTMPVDSRIIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAHRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVIDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSILWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINSCTL-TSTRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >G_gallus_ENSGALP00000007991 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGLKDSVF-------------------- ----------------------------------------------------DGPNCISP TIVQQFGYQRRASDDGKISDTSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MTLHDCLMKALKVRGLQ---- --PECC----------------AVFRLVTEPK-----------------------GKKVR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSNISD------------ SGVPAL--PPLTMRRMRESV--SRI------PVSSQHRYSTPHV-------FTF------ NTSNPSSEGTLSQRQRSTSTP---------NVHMVSTTMPVDSRIIE------------- -------DAIRNHSES-------------------------------------------- ---ASPSALSGSPNNMSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GTNT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSILWMAPEVIRMQDSNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCLKKVREERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAS-HTEDINSCTL-TSTRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >D_rerio_ENSDARP00000048390 ---MAALS------------------------SAESPPPVFNGDTMNRDPERDPGLDELG AGLEPACPGEAAIPECQQGIPEEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLEAIGNGTEF--CSSPTPTLLDVK------GQGIQSAP TAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------MTVRDSLKKALMMRGLI---- --PECC----------------AVYRVQ---D-----------------------GEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLASKFLVHHPITQEEVSSEGTTPIS EMCPSL--PPSESTGSLCHP--TVS------P-----SKSIPIP-------QSF------ RPGEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGLPRSDGAPSQHPARCLRKNRTRTSSPLLSSHPNDIVFDFEPEPVFR AMPGSTTGLSATPPASLPGSLP------NVKV-S-------KSP-CQPRERK--P----- -----SSSS-----------------EDRNKMKTLGRR------DSSDDWEIPEGQITL- -------------GQRIGSGSFGTVYKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GA-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYTC-ASPKT---------------- ---------------------------PIQAGGYGEFT----AFK--------------- ----------------------------- >M_domestica_ENSMODP00000011339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AERISSS------------------------------- ---WLEVRHIEKYMEQ---GKSGTRELLWS------------------------------ -----------------------W-AQKNKTIGDLL------------------------ ---------------------------------QILQEMGHERA-------INLI----- VNHGR------------------------------------------------------- ----------------T------------------------------------------- ---ISASTKQSQQSAGFPNIPS------Q--------------VPTDSTIDK--QGE-MP EY-RKEIRLK----------------------------------PSFNFKSIIEGTKNFH K------------DLLIGEGEFFKVFRVELQ--------NG--T----YAVKLFKQETTI Q---NK--KNWKMFFSELEVL--NLKSTHHPLYRETSYYHI----SVPSFCSLFQLPPQI SLYKKL-ENVG---DDNTFPLSWQLRLSILIGAAKAIQYLH--H-----VEPCSVICGNI TSSNILLDSQFQPKLTNFVTAHLRPH-------LEKQS----------STINM---ESSR NKYLLYMPEEYIRQ---RRLS------IKTDVYSFGIVIMEVLT-GY-QVVLEGP----K Y-VRLRDLLVE------LMEK-------------------------RG-LESCLSLLDK- K--I-SPCPQN--FS--WK-LFT-LANQCASSRAKLRPTMD------------------- --------------------------E-VLVALESSCPNLH-FTEDP------------- --------PKSLKSFRSP--SPLF------------------------------------ ------------------------------------LNHLPSVPMENDENQDFCSLP-NE NLDKDGFAQKTPLECSQSEVTFLGLDRKALGKGKTPVSEVPVSS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------WEDNFSSNHLH---------------------------------- ------------------------------------------------------------ -----------PSQDSSVCVMNMYLSSES-GNPVLSKLVEPSSSSESYRNKNEEMEKM-- ------------------------------------------------------------ ----------------------------- >G_aculeatus_ENSGACP00000004834 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ACP V------SSCRSSGETSPEDVPRGGGTIRVYLPNKQRTV--------------------- -----VNVRQG------------------------------------------------- ---------------------------------------QTVYESLDKALKVRGLS---- --QDCC----------------AVFRLL---E-----------------------GRKRL TDWETDITPLV--------GEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGF RCQTCGYKFHQHCSSKVPTVCVDMDTVT-----K----RNDTNPCTDE------------ YPRILL--PENSPSQSNLAL--TPE------P-AGTDLLSPTSA-------FHF------ --PMPSGEGQSLQRHRSTSTP---------NVHMVSTVGPAGTSIIE------------- -------EALKSNNILVLAGPE-------------------------------------- ---PSPKPSTSPPSSLGSPGRR--------P--P-------KSP-SEHKERK--P----- ------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHSREVTI- -------------QKRIGAGSFGTVFKGKWH---------GD------VAIKILKVTEPT P-------EQLQAFKNEMQVL--RK--TRHVNILLFMGYMT----K-PNFAIITQWCEGS SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDL KSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP SGSILWMAPEVIRMQDSNPYT------FQSDVYGYGVVLFELMS-GT-LPYCNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLFCT--SP--KS-MKR-LIVDCLKFKRDERPLFP------------------- --------------------------Q-ILVAIEQVQDLLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIERSRSEPSLHRAV-HAEDLNPLLF-HTTRL---------------- ---------------------------M-------------------------------- ----------------------------- >A_carolinensis_ENSACAP00000013056 ---MDHIH---------------------------------------------------- ----------------------GAWKAL-TDGIGLKDSVF-------------------- ----------------------------------------------------NGSSCISP TIVQQFGYQRRASDDGKLSDSSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MTLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLNEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAYCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PHSNVGE------------ SGMPAL--PPLTTRRMRESV--SRI------PVNSQHRYSTPHA-------FTF------ SPSNPSPECSLSQRQRSTSTP---------NVHMVSTTMPVDNRIIE------------- -------DAIRSHSES-------------------------------------------- ---ASPPAISSSPNNTSPTGWS--------Q--S-------KTPVPAQRERA--S----- -----GSNA-----------------QEK-KIRPRGQR------DSSYYWEIEASEVML- -------------STRVGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMLQRIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEDRTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDSNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVREERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAT-HTQDINACTL-TSTKL---------------- ---------------------------PI---------------F--------------- ----------------------------- >T_nigroviridis_ENSTNIP00000010036 ---MAALS------------------------SAESPPPVFNGDAAEREPGRERGLEEPG SGFNTAY--TTRIPGGAQN--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPTIYL E--AYEEYTSKLDALQQREQQLLEAMGNGADFPCSPSPMPALLEVKMGGCGIGGGAQ--- -TPSSLAVLQTPIDGNRINPRSPQKPIVRVFLPNKQRTV--------------------- -----VSARCG------------------------------------------------- ---------------------------------------MTVRDSLKKALTMRGLI---- --PECC----------------AVYRIQ---D-----------------------GEKKP IGWDTDISWLT--------LEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVS EVCPSL--PPSDSIGSICHS--TVS------P-----SKSIPIP-------PSF------ RSSEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGLPRSDGAPLTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPIFR ---GSTTGLSATPPASLPGSLT------NVKIPQ-------KSP-CQQRERK--S----- -----SSSS-----------------EDRSKMKTLGRR------DSSDDWEIPEGQITL- -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GV-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGEYTHSGIPVN--------------- ----------------------------- >T_rubripes_ENSTRUP00000029372 ---MAALS------------------------SAESPPPVLNGDAAERDPGRERGLEELD SGFNSAC--TTRVPGGAQN--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPTIYL E--AYEEYTSKLDALQQREQQLLEAMGNGTDFPCSPSPMPALLEVKMGGCVPGVGAQ--- -APNSLAVLQTPTDGSRVNPRSPQKPIVRVFLPNKQRTV--------------------- -----VSARCG------------------------------------------------- ---------------------------------------MTVRDSLKKALTMRGLI---- --PECC----------------AVYRMQ---D-----------------------GEKKP IGWDTDISWLT--------LEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVS EVCPSL--PPSDSTGSICQS--TVS------P-----SKSIPIP-------PSF------ RSSEEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRVQGLPRSDGAPPTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPVFQ ---GSTTGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----- -----SSSS-----------------EDRSKMKTLGRR------DSSDDWEIPEGQITL- -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GV-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGGYGEFS----AFK--------------- ----------------------------- >D_rerio_ENSDARP00000044241 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSVHRYSNPHV-------SNY------ TSPYPPSGAALTQRLRSTSTP---------NVTMLSTTVPVDSSLIE---LDTSPSSWCQ QFSLKRRDAIRVHSSA-------------------------------------------- ---------GSSPNQ-SPTGWN--------QASA-------HIP-------A--S----- -----ALNP-----------------QEKVKIRPRDKR------DSSYYWEIEANEVVL- -------------LSRIGSGSFGTVHKGKWH---------GD------VAVKVLKVTNPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-GNLAIVTQWCEGS SLYKHL-HVL-------ETNFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------QQ------VEQP SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFELMT-GE-LPYSQIG----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLYKR--CP--KA-MKR-LVADCIKKSKDERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAS-QSEDISSCTL-TSMKL---------------- ---------------------------PV---------------F--------------- ----------------------------- >P_troglodytes_ENSPTRP00000025252 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SNGFGFKDAVF-------------------- ----------------------------------------------------DGSSCISP TIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV--------------------- -----VNVRNG------------------------------------------------- ---------------------------------------MSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTIGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTPHA-------FTF------ NTSSPSSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRMIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----VSGT-----------------QEKNKIRPRGQR------DSSYYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVNPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWMAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQIIFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-MKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTEDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >T_rubripes_ENSTRUP00000016249 ---MEHLQ---------------------------------------------------- ----------------------GAWKTL-SNGFGMKETEF-------------------- -----------------------------------------------------DSPCLSP TMVQGYPCQRRSSDDSKMPD-SKTSSTIRVYLPNQQRTVVSGFGLRCAETKVP--RGIKD VFVHQVNVRPG------------------------------------------------- ---------------------------------------MTLHSCLIKALKVRGLQ---- --PQCC----------------AVFRLHPGQS-----------------------SKKLR MDWNTDSTSLI--------GQELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF-----PSPGD------------ GGGPSL--PPLTSRRMRESL--TRF------P-SSAHRYSTPHA-------FNY------ NTSYPPAGGGLSQRQRSTSTP---------NVHMVSTTLPVDSSMIE------------- -------DVMRDHDSA-------------------------------------------- ---------GSSPNQ-SPTGWS--------QSQS-------KAPAPSQRERA--T----- -----SFNT-----------------QEKNKIRPRDKR------DSSYYWEIEASEVYL- -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTNPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHI-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------NQ------VEQP SGSILWMSPEVIRMQDNNPYS------FQSDVYSYGIVLFELMT-GE-LPYSQTG----N RDQIIYMV--------------------------------------------GRGYLSP- D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP------------------- --------------------------Q-ILSSIELLQHALP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAS-HTEDINACTL-TSTRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >G_aculeatus_ENSGACP00000025456 ---MAALS------------------------SAETQPPVFNGDTAEREPGREQGLEEL- ---------------GPQD--EEIWN-I-KQMIKLTQEHLEALLDKFGGEHN--PPSIYL E--AYEEYTSKLDALQQREQQLLEAMGNGTDFSCSPSPMPALLEVMSGGCGVAGGAQAFP SAPNTLAVLQTPTDAGRANPRSPQKPIVRVFLPNKQRTV--------------------- -----VPARCG------------------------------------------------- ---------------------------------------MTVRDSLKKALMMRGLI---- --PECC----------------AVYRIQ---D-----------------------EEKKP IGWDTDISWLT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDQLD-----LLLVSKFFEHHPFTQEEVSSEGTTPVS DACPSL--PPSDSTGSMCHT--TLS------P-----SKSIPIP-------PSF------ RPNDEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGLPRSDGAPPTHPARCLRKHRTRTSSPLLYSYPNDIVFDFEPEPVFR ---GSTAGLSATPPASLPGSLT------NVKVPQ-------KSP-CQQRERK--S----- -----SSSS-----------------EDRNKMKTLGRR------DSSDDWEIPEGQITL- -------------GQRIGSGSFGTVFKGKWH---------GD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYTT----K-PQLAIVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRLQDKNPYS------FQSDVYAFGIVLYELMS-GA-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKVRSN--CP--KA-MKR-LMADCLKKKREERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYAC-ASPKT---------------- ---------------------------PIQAGCYGELMH--ITTI--------------- ----------------------------- >T_nigroviridis_ENSTNIP00000015593 ---AR------------------------------------------------------- -----------------------AWKTL-SNGFGMKETEF-------------------- -----------------------------------------------------DSPCLSP TMVQGFPCQRRSSDDGKMPD-SKTSSTIRVYLPNQQRTV--------------------- -----VNVRPG------------------------------------------------- ---------------------------------------MTLHSCLIKALKVRGLQ---- --PQCC----------------AVFRLHPGQS-----------------------SKKLR MDWNTDSTSLI--------GQELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF RCQTCCYKFHEHCSTKVPTMCVDWSNIR-----QLLLF-----PSPGD------------ SGAPSL--PSLTSRRMRDSL--TRF------P-SSAHRYSTPHA-------FNY------ NTSYAPTGGGLSQRQRSTSTP---------NVHMVSTTLPVDSSMIE------------- -------DVMRDHDSA-------------------------------------------- ---------GSSPNQ-SPTGWS--------QSHS-------KAPAPSQRERA--T----- -----SFNT-----------------QGEHKIRPRDKR------DSSYYWEIEASEVYL- -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTNPT P-------EQFQAFRNEVAVL--RK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHI-HVL-------ETNFKIIQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------HQ------VEQP SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLFELMA-GE-LPYSQTG----N RDQIIYMV--------------------------------------------GRGYLSP- D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP------------------- --------------------------Q-ILSSIELLQHALP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAS-HTEDINACTL-TSTRL---------------- ---------------------------PI---------------F--------------- ----------------------------- >T_rubripes_ENSTRUP00000004702 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCMKSTLCES-----------LGS GLE-----RKNSPQTVGAEQRHYVRD------PTFEAKHNF------------------- ------------------------------------------------------------ ---------------------------------------LSQNSSLLPGQRFQTMEDKV- VGKIMV----------------GLYPYEALHA---------------------------- ----DDLGFKK--------GERM--KILEE------------------------------ ---------------HGE-----WWKAK-----SLT------------------------ TNREGF--IPSNYVGQADTM--ETE------D-WFFKDISRKDA-------ERQ------ LLAPANRPGSYLIRESETSK----------GSFSLSIRVVDDSGA--------------- -------DSVKHYKIRL------------------------------------------- ---MDNGGYYISPKITFNDISS------MIKHYH-------NKADGLCRNLD--R----- -----PCVKP--------------K-----AQ----KP------WDKDAWEIPKECIKM- -------------VKKLGAGQFGEVWMAYYN---------NTTK----VAVKTLKPG--T M--------TVEAFLDEANLM--KK--LQHDRLVRLYAVVT----KTEPIYIITEFMANG SLLDFL-KSD------SGCTLPMPKLIDFSAQIAEGMAYIE----------KKNYIHRDL RAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIVTYGK-NPYPGMT----K G-EVISSI--------------------------------------------QRGYRMP- Q-------TDN--CP--TE-LYS-MMLNCWKEKPEERPTFE------------------- --------------------------Y-MQSVL----NDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQQQP------------------------------------- ------------------------------------------------------------ ----------------------------- >A_gambiae_AGAP011710-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RCSVCDARLSSWYFEKDGLLFC RDDHWSKFGDCCQQCSQFISGPAMFAGDHKFHPECFRCESCKVFIGDRESYALLERSKLY WYVLTGAKNAIAPPKDRIISNRIRVRYLIP------------------------------ --------------HSIRLVEIPWSGNRSDRIRLAT------------------------ DDKPSGVKGVANGCKSCTCINQLFANICFPHRVTLNSDLMALRVGDKVLEVNGTPVRDVP LESLQNLIEASAGKALQLTVEHDPDVVALATAGGLPGCKGILSASYAGTETNCTDVLNNN QNEGE------------------------------------------------------- ---EEPTPSKCEILMLLSHLPP--------------------TATNSLKEKERSSSMSRL LDEHRTMATG--------------GEFYDLSRTKSFRV------EPKAARIFRASDLVQ- -------------GELLGKGFFGQVFKVTHR--------VTQEV----MVLKELYRVDE- --------EAQKNFLKEVAVL--RS--LSHHNVLRFIGVLY----KDKKLHLVTEFIPGG SLKELI-HD-------SGLPLSWAQRISFARDISSGMSYLH----------SMNIIHRDL NSLNCLVRENGTVIVADFGLARIIKQPLIST---TAYE----------KPRRQ---RYTV VGNPYWMAPEMMRG---NKYD------EKVDIFSFGIMLCEIIG-RV-QADPDYL----- --PRLPDFGLN-----------------------------------------EKVFREK- -------FCGQ--CP--EP-FYK-IAFLCCDLNPDKRPPFH------------------- --------------------------V-LQGWLETMATVVALQRPIPIRIIDEIDNFKGL RSTESSLCTTPDGELLTPTNSSTPRPVEERIE---------------------------- --------------------------PTAQAGPGFVVVDFNDIPKSPHLGKDFSANGDRI RDSLRAKRRQRMMLSRENQRKSLDSSLLVAAARLGATDRLM------------------- -------------------------------------GEAGFVIHVQNGHLTLNNVRDLE NCSDFDSSCDTSLNYLEVNGNRVEQQE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000014365 ---MEHLQ---------------------------------------------------- ----------------------GAWRTL-SNGFGMKDSAF-------------------- -----------------------------------------------------EGPCLSP TMVQGFPSQRRSSNDSRTPN-SKASSTIRVYLPNQQRTVVSSI----AQNFMPISRTLKS TSKTVVNVRPG------------------------------------------------- ---------------------------------------MTLFNCLIKALKVRGLQ---- --PQCC----------------AVFRLHPGQT-----------------------NKKLR MDWNTDSTSLI--------GEELLVEVLDHVPLTTHNFVRKTYLKLAFCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLC-----PTPGE------------ SGGPSF--PPPTSRRVRDSL--TRF------P-SSAHRFSTSHA-------FND------ TEPYTPPGGGLSQRQRSTSTP---------NVHMGSTTLPVDSSMIE------------- -------DAMRDHDSA-------------------------------------------- ---------GSSPNQ-SPTGWS--------HSQS-------KTPTPAQRERA--P----- -----SFTA-----------------QEKNKIKPRDKR------DSSYYWEIEASEVYL- -------------HSRIGSGSFGTVYKGKWH---------GD------VAVKILKVTDPT P-------EQLQAFRNEVAVLRCRK--TRHVNILLFMGYMT----K-DNLAIVTQWCEGS SLYKHI-HVL-------ETNFKMIQLIDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HQ------VEQP SGSILWMAPEVIRMEDNNPYS------FQSDVYSYGIVLFELMT-GELLPYINTR----G NDQIIFMV--------------------------------------------GRCCLSP- D--L-SKLYKN--CP--KA-MKR-LVADCIKKSKDERPLFP------------------- --------------------------Q-ILSSIELLQHALP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAS-HPEDINTYTL-TSTKL---------------- ---------------------------PV---------------F--------------- ----------------------------- >D_rerio_ENSDARP00000008826 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCACSDQNHPK------------- --------GHEHYNSTNSKTSHASRD---------------------------------- ------------------------------------------------------------ -------------------------------------------------HKKQNNNQDE- --DVVI----------------AQYDFQPASE---------------------------- ----NDLQFKK--------GDRL--RIIKE------------------------------ ---------------NGE-----WWLAK-----SLV------------------------ TGYEGF--IPSTYVARAQTL--QVE------R-WFFKDMNRRDT-------ERL------ LLAPGNKPGSFLVRESETTK----------GAFSLSIRDSTPEQG--------------- -------DVVKHYKIRA------------------------------------------- ---LDNGGYYISPSTSFSSLQE------LVKYYS-------RTADGLCQRLG--N----- -----PCKST--------------A-----PQ----RP------WAQDEWEIPRETLKL- -------------VKKLGAGQFGEVWMGFYK---------NNQK----VAIKTLKEG--T M--------EPEAFLQEANLM--KQ--LQHERLVKLHAVVT----R-EPIYIVTEYMANG SLLDFL-KTD------DGHKLKLSKLIDMTAQIAEGMAYIE----------RKNYIHRDL RAANILVSETLHCKIADFGLARIIE---------TE-Y----------TA------QEGA KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTYGR-VPYPGMT----N P-EVIRNL--------------------------------------------DRNYRMP- C-------PDA--CP--GE-LYD-IMTKCWMEKPEDRPTFE------------------- --------------------------Y-LQDTL----NDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IATEGQYEMQP------------------------------------- ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000003552 ---MEHIQ---------------------------------------------------- ----------------------GAWKTI-SSGFGFKDAVF-------------------- ----------------------------------------------------DGPSCICP TIVQQFGYQRRASDDGKLTDSSKTSNTICVFLPNKQRTV--------------------- -----VSVRNG------------------------------------------------- ---------------------------------------VSLHDCLMKALKVRGLQ---- --PECC----------------AVFRLLHEHK-----------------------GKKAR LDWNTDAASLI--------GEELQVDFLDHVPLTTHSFARKTFLKLASCDICQKFLLNGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLLF---PNSTFGD------------ SGVPAL--PSLTMRRMRESV--SRM------PVSSQHRYSTLHA-------FTL------ NISSSCSEGSLSQRQRSTSTP---------NVHMVSTTLPVDSRVIE------------- -------DAIRSHSES-------------------------------------------- ---ASPSALSSSPNNLSPTGWS--------Q--P-------KTPVPAQRERA--P----- -----GSGT-----------------QEKNKIRPRGQR------DSSCYWEIEASEVML- -------------STRIGSGSFGTVYKGKWH---------GD------VAVKILKVVDPT S-------EHFQAFRNKVAVL--HK--TRHVNVLLFMGYMT----K-DNLAIVTQWCEGS SLYKHL-HVQ-------ETKFQMFQLIDITRQTAQGMDYLH----------AKNIIHRDM KSKNIFLHEGLTVKIGDFGLATVKSR--------WSGS----------QQ------VEQP TGSVLWLAPEVIRMQDNNPFS------FQSDVYSYGIVLYELMT-GE-LPYSHIN----N RDQILFMV--------------------------------------------GRGYASP- D--L-SKLYKN--CP--KA-VKR-LVADCVKKVKEERPLFP------------------- --------------------------Q-ILSPVELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAA-HTKDINACTLTTSPRL---------------- ---------------------------PV---------------F--------------- ----------------------------- >D_rerio_ENSDARP00000071167 ---MS------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------N T------SSCSSSGETSPDDTPRGGGTIRVYLPNKQRTV--------------------- -----VNVRPG------------------------------------------------- ---------------------------------------QTVYDSLDKALKVRGLS---- --QDCC----------------AVFRLL---E-----------------------GRKRL TEWDTDITPLV--------GEELLVEVLDDVPLTMHNFVRKTFFKLAYCDFCHKFLFNGF RCQTCGYKFHQHCSSKVPTVCVDMDTMT-----K----RCVNN--TED------------ CPAILIYPATNSISQSDLPL--TSD------S-PGGELPSSPSN-------FCL------ --FIRGEDGQSLQRHRSTSTP---------NVHMVSTLEPGAAGLLE------------- -------EPFKISTVASSTGYE-------------------------------------- ---SSPKPSTSPP-HLGSPGRK--------P--P-------KSP-SEPKERK--Q----- ------SSS-----------------DDKKKVHRGGYR------DSSYYWEVHPREVSM- -------------LKRIGAGSFGTVFKGKWH---------GD------VAIKILKVTEPT P-------EQLQAFKNEMQVL--RK--TRHVNILLFMGFMT----R-PNFAIITQWCEGS SLYRHL-HVT-------ETKFDTMRRIDVARQTAQGMDYLH----------AKNIIHRDL KSNNIFLHEGWTVKIGDFGLATVKSR--------WSGS----------RSNSP---VAPS CGCLLHMAPEVIRMQDTNPYT------FQSDVYGYGVVLYELMS-GT-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--L-SKLYSN--CP--KS-MKR-LIIDCLKFKRDERPLFP------------------- --------------------------Q-ILVSIEQVQELLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIERSASEPSLHRAV-HAEDLNPLLL-HTTRF---------------- ---------------------------L-------------------------------- ----------------------------- >C_familiaris_ENSCAFP00000011788 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GVGSSK-----------------K QVK-----EKEKGQWSPVKVSTQSKD------PPPLPP---------------------- ------------------------------------------------------------ ---------------------------------------LILFNHLTPAPPDACLDQEE- --RFVV----------------ALYDYSSVND---------------------------- ----RDLQMLK--------GEKL--QILKE------------------------------ ---------------AGD-----WWWAR-----SLI------------------------ TGREGY--VPSNFVTRVETL--EVE------K-WFFRSISRKDA-------ERQ------ LLAPVNKAGSFLIRESETNK----------GAFSLTVKDVT-TQG--------------- -------EMIKHYKIRS------------------------------------------- ---LDEGGYYISPRITFPTLQA------LVQHYS-------QKGDGLCQRLT--Q----- -----PCVSL--------------A-----PQ----NP------WAQDEWEIPRQSLKL- -------------VRKLGSGQFGEVWMGYYK---------NNVK----VAIKTLKEG--T M--------SPEAFLGEANLM--KT--LQHERLVRLYAVVT----K-EPIYIVTEYMARG CLLDFL-KTV------EGSRLSLPRLIDMSAQIAEGMAYIE----------QMNSIHRDL RAANILVSETLCCKIADFGLARII-D--------SE-Y----------TA------QEGA KFPIKWTAPEAIHF---GVFT------IKADVWSFGILLMEIVTYGR-VPYPGMS----N P-EVIRSL--------------------------------------------ERGYRMP- R-------PDS--CP--PE-LYHGVIAECWRSRPEERPTFE------------------- --------------------------F-LQSVL----EDFH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEQQYELQP------------------------------------- ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000015921 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCIKSILIGE-----------LTN GVE-----EKGSQQAAQTDQAHYVRD------PTSTSKSTR------------------- ------------------------------------------------------------ ---------------------------------------LK-SNSLLPGQVFQKLEEENK SYKIVI----------------GLYPYEAVHS---------------------------- ----DDLGFKK--------GEKM--KVLEE------------------------------ ---------------RGE-----WWKAR-----SLT------------------------ TNKEGF--IPCNYVAQANTM--ETE------E-WFFKDLTRKDA-------ERQ------ LMAPANKPGSYLIRESETSK----------GSYSLSIRDRDNQGM--------------- -------DLVKHYKIRK------------------------------------------- ---LDNGGFFISPKISFNDIGS------MVKHYH-------SKADGLCRKLE--S----- -----PCVKP--------------K-----AQ----KP------WAKDAWEISKDSIKM- -------------VKKLGAGQFGEVWMAYYN---------NTTK----VAVKTLKPG--T M--------TVEAFLEEANIM--KT--LQHERLVRLYAVVT----KTEPIYIITEYMANG SLLDFL-KSE------VGGKLQLPKLIDFSAQIAEGMSFIE----------KRNYIHRDL RAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIITFGK-IPYPGMT----K G-EVVSSI--------------------------------------------QRGYRMP- R-------PEN--CP--TQ-LYE-IMTSCWKFRPEDRPTFE------------------- --------------------------Y-MQSVL----DDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEDQYQHQP------------------------------------- ------------------------------------------------------------ ----------------------------- >O_anatinus_ENSOANP00000008740 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCIKSKRKDNL----------NDD GID-----LKSQP-VRNTDRTIYVRD------PTSNKQQRPV------------------ ------------------------------------------------------------ ---------------------------------------LCSDSHLLPGQRFQSKDPEE- QGVIVV----------------ALYPYDGIHQ---------------------------- ----DDLSFKK--------GEKL--KVLEE------------------------------ ---------------HGE-----WWKAK-----SLS------------------------ TKREGF--IPSNYVAKVNTL--ETE------E-WFFKDITRKDA-------ERQ------ LLAPGNSAGAFLIRESETQK----------GSFSLSIRDFDPQQG--------------- -------DVIKHYKIRS------------------------------------------- ---LDNGGYYISPRITFTCISD------MIKHYQ-------KQSDGLCRRLE--K----- -----VCISP--------------K-----PQ----KP------WDKDAWEIARESIKL- -------------VKKLGAGQFGEVWMGYYN---------NTTK----VAVKTLKPG--T M--------SVQAFLEEANLM--KT--LQHDKLVRLYAVVT----KEEPIYIITEYMAKG SLLDFL-KSD------EGGKVLLPKLIDFSAQIAEGMAYIE----------RKNYIHRDL RAANVLVSEALKCKIADFGLARIIED--------NE-Y----------TA------REGA KFPIKWTAPEAINF---GSFT------IKSDVWSFGILLYEIVTYGK-IPYPGRT----N A-DVMTAL--------------------------------------------QQGYRMP- R-------MEN--CP--DE-LYD-IMKMCWKEKAEERPTFD------------------- --------------------------Y-LQSVL----DDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQQQP------------------------------------- ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000021561 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------M------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------ASAPQTSLHMRPTDLI K------------REPLDYGGFGEVYLCYHA---------TLGQ----VVLKTLYTGPLR S------EESKRSLLEEGSIM--AS--LNHERVVKLLGVVM----EDRDCSLVLELLPRG NLLVML-ETVK---------VPISIKGRIILEVLEGMIYLT----------EKRVIHKDI KPENILVDKDFHIKIADLGLATCQTWSKLT--KEESRR----------KSRSGQTSGARG AGTLSYMAPEHLRSIH-TPST------EKSDVYSFGIVVWVILT-GE-EPYANAR----S EDQISRCV--------------------------------------------RDGDRPA- E----DLIPED--TP--SE-VVQ-LMKRCWSDNPEERPSFK------------------- --------------------------E-AYDIFCPFYAKNLEPHIENDLQDLKENYEGPM TLVEKMKLLSVRHDSFLTNEQVPL------------------------------------ -----------------------------------------DSPAPLVSSDTNVSVPVEA SIEDLHVINYKPLGDSIQADARQPSELEEKLGRELYYHIHGSYNSDMHPPAASSYYNNAP NHLLQNHVSPLDQSGRPPARDTSSVHSWTKEPVQPTGSDQLFFPLNPVNPSSMASPTPTH LNASASMSSLQQVNQHLHPHLDRQQSWPVYPVPDT------------------------- FVPDMNASGCGTPSKGFQPQEPGPLFI--------------------------------- ------------------------------------------------------------ -----------QNASGIQIGNNNTLSIRAFDNPVSSQCVSGSSLSPIQEGLLKFLEDQAV TEEHLYLLTENIGNSWKRCARRLGLKDVEIQTIEHDYYRDGLPEMVHQMLERWKMKEGSI GCTVGKLCRALDGNIKVDVIQKILDMCGL >M_domestica_ENSMODP00000011408 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCIKSKRKHSS----------THD GID-----LKTQP-VRNTDRTIYVRD------PTNKQQRPLPE----------------- ------------------------------------------------------------ ---------------------------------------YHLYSDLLPGQRFQSNDSEE- --EMVI----------------AIYPYEGLHP---------------------------- ----DDLSFKK--------GEKM--KVLEE------------------------------ ---------------YGE-----WWKAK-----SLS------------------------ TKKEGY--IPSNYVAKLNSL--ETE------D-WFFKDITRKDA-------ERQ------ LLLPGNRVGAYLIRESETLK----------GGFSLSVRDYDPLHG--------------- -------DVIKHYKIRS------------------------------------------- ---LDNGGYYISPRITFPTITD------LIKHYQ-------RQPDGLCRRLD--K----- -----ACIST--------------Q-----PQ----KP------WDKDAWEIPRESIKL- -------------VKKLGAGQFGEVWMGYYN---------GSTK----VAVKTLKPG--T M--------SVQSFIEEANLM--KT--LQHEKLVRLYAVVT----KEEPIYIVTEFMAKG SLLDFL-KSG------EGTKLLLPKLIDFSAQIAEGMAFLE----------RKNYIHRDL RAANVLVSESLICKIADFGLARIIRD--------DE-Y----------KA------REGA KFPIKWTAPEAINF---GSFS------IKSDVWSFGILIYEIITYGK-VPYPGRT----N A-EVIMAL--------------------------------------------GKGYRMP- R-------MDS--CP--NE-LYD-IMSMCWKERAEERPTFD------------------- --------------------------Y-LQSVL----EDYY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQQQP------------------------------------- ------------------------------------------------------------ ----------------------------- >A_gambiae_AGAP006219-PA ---MFVCT---------------------------------------------------- ---------SFLIVHSPTLSLSLSLSPFSRLTFTPSGTAGYARTASAGNGSSSNSYSPNG KFKRRKKTEKLHQQQQQDALEEDTIEPGVCQVYTGTTCEQYLRNQTVFVTPDITMEILEE RLKSAYGVIRESKDMNANCRVYALPSLCYSILPVCRTPELTNHQYFANRAAAEAAQRAAT IGRGKMRAHEKKNNRKQLLRGNGTLTTTERLRVYFSGGVTPDLGGRFFDGEIVTENSLPP RYDNARRGRRAAGHQQYVQPGEEITVLSYTSSSSGPKKSYPPTRNTENLRRICRNDCELL ENELCQ----------------KEYAIAKRHPTIGQKLPLEECDDLPLQKSCMRLGIDLD IKPNDDCYWEN--------GASY--RGIMDR----------------------------- --------------TKSSKICMRWSKLM-----HTM------------------------ SEFPHL--AGHNYCRNPPHAGPMDA------P-WCYVD--MQKT-------IEY------ CDIPKCSERMWMYIIIGFVAVISPLFI---GIGVFCCRKYRKHGV--------------- -------SNIQNINLPN------------------------------------------- ---ADKNIYGNSRLNSPIEMTS------LIANQSSTGAASRNAENGGIQGLT--TGQPGN --GHNPGQSS--------------Q-----SR----NN------GISRVPQYTLQDVRF- -------------VEELGEGAFGKVYKGELT---------QKNGERIFVAVKALKENA-S A-------KTQADFKREIELI--SD--LKHDNIVCILGVVL----KEEPLCMLFEYMAQG DLHEFL-IANS---PNEGKSLSQLQFLLIAQQICDGMEYLA----------SHHYVHRDL AARNCLVGDNLTVKISDFGLSRDIYS--------SDYY----------RV------QSKS LLPVRWMPSESILY---GKFT------TESDVWSFGVVLWEIYSYGL-QPYYGYS----N Q-EVINMV--------------------------------------------RARQLLP- C-------PES--CP--SA-VYS-LMVECWHEQAVRRPTFP------------------- --------------------------E-IGHRL----KIWY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QAQKRSK----------------------------------------- --------------------------------------------C--------------- ----------------------------- >G_aculeatus_ENSGACP00000018983 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCMKSRLTDG-----------LSG GVE-----GKTGEQTVHTDRMDFVKD------PTSNRTSNC------------------- ------------------------------------------------------------ ---------------------------------------AP-DNFLLPGQRFQKREEQSG VGKIVI----------------SLYPYEALHD---------------------------- ----DDLGFKK--------GEKM--KILEE------------------------------ ---------------HGE-----WSKAK-----SLT------------------------ TNKEGF--IPGNYVAQADSM--ETE------E-WFFKDITRKDA-------ERQ------ LLAPANKPGSYLIRESETSK----------GSYSLSVRDVGAEGT--------------- -------DSVKHYKIRT------------------------------------------- ---MDDGGYYISPKISFPSIAA------MIKHYH-------HKADGLCRKLD--R----- -----ACVKP--------------Q-----AQ----KP------WDKDAWEISKNSIKM- -------------VRKLGAGQFGDVWMAYYN---------NTTI----VAVKTLKPG--T M--------TAEAFMEEANVM--KT--LQHDRLVRLYAVVT----KTPPIYIITEYMANG SLLDFL-KSD------AGCRLQLPKLIDFSAQIAEGMAFIE----------RKNYIHRDL RAANVLVSESLLCKIADFGLARVIED--------DE-Y----------SA------REGA KFPIKWTAPEAINY---GTFT------IKSDMWSFGVLLFEIITYGK-IPYPGMT----K G-EVISSV--------------------------------------------QRGYRMP- Q-------PGN--CP--NE-LYA-IVMLCWKNKPEDRPTFD------------------- --------------------------Y-MQSVL----DDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQQQP------------------------------------- ------------------------------------------------------------ ----------------------------- >C_familiaris_ENSCAFP00000015667 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCSCSSNPEDDWMENIDVCENCHY PIV-----PLDGKATLPMRNGSDVRD------PL-------------------------- ------------------------------------------------------------ ---------------------------------------VIYEGSNPPASPLQD------ --NLVI----------------ALHSYEPSHD---------------------------- ----GDLGFEK--------GEQL--RILER------------------------------ ---------------NGE-----WWKAQ-----SLT------------------------ TGQEGF--IPFNFVAKANSL--EPE------P-WFFKNLSRKDA-------ERQ------ LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG--------------- -------EVVKHYKIRN------------------------------------------- ---LDKGGFYISPRITFPGLHE------LVRHYT-------NSSDGLCTRLS--R----- -----PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--S M--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG SLVDFL-KTP------PGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDL RAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----N P-EVIQNL--------------------------------------------ERGYRMV- R-------PDN--CP--EE-LYQ-LMMLCWKERPEDRPTFD------------------- --------------------------Y-LRSVL----EDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQPQP------------------------------------- ------------------------------------------------------------ ----------------------------- >B_taurus_ENSBTAP00000037887 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCSCSSNPEDDWMENIDVCENCHY PIV-----PLDGKTTLPMRNGSEVRD------PL-------------------------- ------------------------------------------------------------ ---------------------------------------VTYEGSNPPASPLQD------ --NLVI----------------ALHSYEPSHD---------------------------- ----GDLGFEK--------GEQL--RILEQ------------------------------ ---------------NGE-----WWKAQ-----SLT------------------------ TGQEGF--IPFNFVAKANSL--EPE------P-WFFKTLSRKDA-------ERQ------ LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQTQG--------------- -------EVVKHYKIRN------------------------------------------- ---LDKGGFYISPRVTFPGLHE------LVRHYM-------NTSDGLCTRLS--R----- -----PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--S M--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG SLVDFL-KTS------EGIKLTINKLLDMAAQIAEGMAFIE----------EQNYIHRDL RAANILVSHSLSCKIADFGLARLIED--------NE-Y----------TA------REGA KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----N P-EVIQNL--------------------------------------------ERGYRMV- R-------PDN--CP--EE-LYQ-LMMLCWKERPEERPTFD------------------- --------------------------Y-LRSVL----EDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQPQP------------------------------------- ------------------------------------------------------------ ----------------------------- >M_musculus_ENSMUSP00000100967 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MARRSSRVSWLAFEGWESRDLPR VSPRLFGAWHPAPAAARMPTQRWAPGTQCMTKCENSRPKP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GELAFRK--------GDMV--TILEACEDKS------------------------- -----------------------WYRAKHHG----------------------------- SGQEGL--LAAAALRQREAL--STDPKLSLMP-WFHGKISGQEA-------IQQ------ LQPPE--DGLFLVRESARHP----------GDYVLCVSFG-------------------- -------RDVIHYRVL-------------------------------------------- ---HRDGHLTIDEAVCFCNLMD------MVEHYT-------KDKGAICTKLV-------- ------------------------KPRRKQGAKSAEEE------LAKAGWLLDLQHLTL- -------------GAQIGEGEFGAVLQGEYL--------GQ--K----VAVKNIKCD--- --------VTAQAFLDETAVM--TK--LQHRNLVRLLGVIL----H-HGLYIVMEHVSKG NLVNFL-RTR------GRALVSTSQLLQFALHVAEGMEYLE----------SKKLVHRDL AARNILVSEDLVAKVSDFGLAKAER-----------------------KG------LDSS RLPVKWTAPEALKN---GRFS------SKSDVWSFGVLLWEVFSYGR-APYPKMS----L K-EVSEAV--------------------------------------------EKGYRME- P-------PDG--CP--GS-VHT-LMGSCWEAEPARRPPFR------------------- --------------------------K-IVEKLGRELRSVG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VSAPAGGQEAEGSAPTRSQDP--------------------------- ------------------------------------------------------------ ----------------------------- >R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SQQRWAPGTQCMTKCENSRPKP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GELAFRK--------GDMV--TILEACEDKS------------------------- -----------------------WYRAKHHS----------------------------- SGQEGL--LAAAALRQREAL--STDPKLSLMP-WFHGKISGQEA-------IQQ------ LQPPE--DGLFLVRESARHP----------GDYVLCVSFG-------------------- -------RDVIHYRVL-------------------------------------------- ---HRDGHLTIDEAVCFCNLMD------MVEHYT-------RDKGAICTKLV-------- ------------------------KPKRKQGAKSAEEE------LAKAGWLLDLQHLTL- -------------GAQIGEGEFGAVLQGEYL--------GQ--K----VAVKNIKCD--- --------VTAQAFLDETAVM--TK--LQHRNLVRLLGVIL----H-HGLYIVMEHVSKG NLVNFL-RTR------GRALVSTSQLLQFALHVAEGMEYLE----------SKKLVHRDL AARNILVSEDLVAKVSDFGLAKAELR----------------------KG------LDSS RLPVKWTAPEALKN---GRFS------SKSDVWSFGVLLWEVFSYGR-APYPKMS----L K-EVSEAV--------------------------------------------EKGYRME- P-------PDS--CP--GP-VHT-LMGSCWEAEPSRRPPFR------------------- --------------------------K-IVEKLGRELRSVG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VAAPAGGQEAEGSAPTRSQDP--------------------------- ------------------------------------------------------------ ----------------------------- >C_elegans_F33E2.2a ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTSTTMVTTLDLV------------------------ ---------------------------------TPTSEEQPGPAPESSDFSTVVLSPDGS ELVTQSAPNTPIQHREQANAEFGQKE---------------------------------- ------------------------------------------------------------ ---GSPDPKNMVAATGNASKPS------LNSFYA--------------------DGLGQL RNGLFSCFQP-------------VFGYFGTKTTVEIEK------SEDELWEIPFDAISE- -------------LEWLGSGSQGAVFRGQLE--------NR--T----VAVKKVNQLK-- --------------ETEIKHL--RH--LRHQNIIEFLGVCS----KSPCYCIVMEYCSKG QLCTVL-KSRN--------TITRELFAQWVKEIADGMHYLH----------QNKVIHRDL KSPNILISAEDSIKICDFGTSHMQKK--------MDST------------------MMSF CGTVSWMAPEMIKK---QPCN------EKVDVYSFGVVLWEMLT-RE-TPYANIA----Q M-AIIFGV--------------------------------------------GTNILSL- ------PMPEE--AP--KG-LVL-LIKQCLSQKGRNRPSFS------------------- --------------------------H-IRQHWEIFKPELFEMTEEEWQLAWDSYREFAK CIQYPSTVTRDHGGPKSAFAMEEEIQRKRHEQLNHIKDIRNMYEMKLKRTNKMYDKLQGC FTELKLKESELAEWEKDLTEREQWHNQNSPKAVAAPRAQLRGYPNEGYDDMSSDEDVQPC RGSPYRCSNTSSSSGVQSSPFSRQSSSRSSAGQQTRRSEGANPPKILRNDAIRHSGSYWE TLGGARGSPARDSGFSQDSGMWSAGAGSCTAINGGGQQVCYSQTLYRNGDGRWSDGRIAS RRRVSTSVNKSTAVPGQPVFFTRDSPSRVPHGVISCSSPRSSSKLNRSSYPSRNAPHQLE DGCCCAHARAPRAKSIAVPMTSSSRARSPTPYDNDFENAESFVDPESPKNLKNLEKIVNL PESTSYDEALCNSDVTMNPIYTSPITTYSNPCHVELVDEENANDVDLTSSMDSRRSRSDD ADVESSEEDEGNGNNILNTSMESEDLRYRIDTSQSTMMSSLERSLEIGATRSDGLSDNEM RVQAVKMSIKTHRRTGSNPQALIHQCIDEYTTSATDDSDDAGAVRI-------------- ----------------------------- >C_intestinalis_ENSCINP00000023589 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SFVRVRYEDLQF- -------------HECCGEGTFGSVYRAIWV-------TQGKQE----VAVKKLN----- ------------QMEKEAHVL--SV--LSHRNVIQFYGACV----DAPNFCIVTEYAPYG SLFDFL-ATK------ESEKLEFSQLLSWSRDIGLGMNYLH-------EEAPVAVIHRDL KSKNVVICSDFTLKICDFGASRFFGETI----------------------------VMTI TGTYPWMAPELIQG---LPTS------ELCDVYSFGVVLWEMLT-RE-VPFKGLQ----G F-QVAWVVV-------------------------------------------ENGERPT- -------IPEC--CP--GR-FSS-LMRRCWSSTVSERPSFY------------------- --------------------------D-IIGELNSMMSDDDLGATTNHFLGSK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EEWKSDIEEKRKELQEKEKELGVKEKEMREREEKLNEWEQKLRQEMR- ------------------------------------------------------------ ----------------------------- >A_aegypti_AAEL000187-PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MYGKSDLSCASCYNAIEKDGYIGALGQEWHTDC-------------------- ------------------------------------------------------------ -------------------------------------FRCSVCDSHLSSWYFEKEGLLFC KDDYWAKYGECCQQCGQVISGPVMVAGDHKFHPECFCCESCKIYIGDREAYALLERSKLF CGQCYKKRMNDTTKVDRQIPGSAMTHDIDG------------------------------ --------SSKKIPHSIRLVEIPWSNVKKDGIRLST-----------------------D EHLYGIPSHSAVGCKGVRIS-----------EIDLTSDLMSLHIGDKILEVNGTPVRDAP LENVEKLIQ-SSGKVLQLTVEHDPEVVDRCRLNNAAG-----EHRYTPVDTNCNNAGLTV VGPGVLKE---------------------------------------------------- ---RSPSPNKYDKERMFKKKDEGYMSGTTRKLQKRLKDVNCNNASNSLKEKERSSSMSKL LDEYQHHHHS--------------GDFYDLSRTKSFRV------EQKAARIFRASDLVQ- -------------GELLGKGFFGQVFKVTHR--------VTQEV----MVLKELYRVDE- --------EAQKNFLKEVAVL--RS--LSHNNVLRFIGVLY----KDKKLHLVTEYIPGG SLKELI-HD-------SGLPLPWELRIRFARDISCGMSYLH----------SMNIIHRDL NSLNCLVREDKTVIVADFGLARIIKQPFSTAFEKCSQSNGTGTVGRRGRPRRQ---RYTV VGNPYWMAPEMMRG---NKYD------EKVDIFSFGIMLCEIIG-RV-QADPDYL----- --PRTSDFGLN-----------------------------------------QAVFKEK- -------FCEQ--CP--EP-FYK-IAFLCCDLNPDKRPPFN------------------- --------------------------I-LEVWFESMAHNATLGKPLPVTIAAEIKYFKGQ RSNDSSKCTTPDGLATPPASGVKPSLSRKRINEGMMVEEKENCEKTVKPANNDGGVDMVD CAKSPKGAMATKDSVENNNITSSDSTSSSVNVSGF-ILGVTEIPRSPHLSKDFSPNGDRI RDSIRARRRQRMILNRENQRKSLDSSNL--GLKLNGVDLVINADSSISEPTSLIQIDPNA LKQPSSTEDVLNLVKDSLTNNPQLTRRYDESPRAKRYGEKGFIIQMNNGNLTLNNVKDLE GCSDFDSSCDTSLNYIDVNGTCTNDKNLPQVFVYKTKKTPTLTAHVPTSDAICTSSSSTI NSSKSKSLSVTIEKPPTNRKPPIAGGATSTSSNMLSLNKNRSFRPMESSSPRYSRHQQPV EKYVALSSSLSGSGS--------------------------------------------- ------------NSRTESPSPTSGVSGTQNRSKMSNNRTGILSPESIRKLNARLLETRKL SNEGETGASNFSTRVRSSGSSEKSMGVHKGGNTQQEKKIRSIVKSKRGEIKAAAI----- ----------------------------- >X_tropicalis_ENSXETP00000010512 ---MAAVS-----------------------GGSTEGPSLLNGDLLESETGGLGGAGEM- --------------CASGGYPEEVRGPV-RGGFGVSAYLIRWCLYLGGLLYNCVPP---I Q--AYEEYTSKLDLLQQREQQLLESMGNGTD-----STSLPSELTL------SSVPSNLS LAPSALSALRTPSDPSRINPKSPQKPIVRVFLPNKQRTV--------------------- -----VPARSG------------------------------------------------- ---------------------------------------VTVRDSLKKALMMRGLI---- --PECC----------------AVYRVQ---D-----------------------GEKKP IGWDTDISWIT--------GEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGF RCQTCGYKFHQRCSTEVPLMCVNYDRLD-----LLFVSKFFEHHPISQEEAPFEEVAPAA ESSTPP--PPPDATGPLCLP--STS------P-----SKSIPIP-------QPF------ RP-DEDHRNQFGQRDRSSSAP---------NVH-INTIEPVNID---------------- -------DLIRDQGLQCSEGAPSVQPT-CHRKYHSRDPSPLLHTLPSEIVFDFESDPVCR ---GSTPGLSATPPASLPGSLT------NVKALQ-------KSP-GQQRERK--S----- -----SSSS----------------TEDRSRMKTLGRR------DSSDDWEIPDGQITSS G------------GSHLGGHWAGTGQKAKWH--------FWD------VAVKMLNVTAPT P-------QQLQAFKNEVGVL--RK--TRHVNILLFMGYST----K-PQLRLVTQWCEGS SLYHHL-HII-------ETKFEMIKLIDIARQTAQGMDYLH----------AKSIIHRDL KSNNIFLHEDLTVKIGDFGLATVKSR--------WSGS----------HQ------FEQL SGSILWMAPEVIRMQDNNPYS------FQSDVYAFGIVLYELMT-GQ-LPYSNIN----N RDQIIFMV--------------------------------------------GRGYLSP- D--F-SKVRSN--CP--KA-MKR-LMADCLKKKRDERPLFP------------------- --------------------------Q-ILASIELLARSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KIHRSASEPSLNRAGFQTEDFSLYTC-ASPKT---------------- ---------------------------PIQAGGYGGFA---IRAL--------------- ----------------------------- >P_pygmaeus_ENSPPYP00000020565 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GLVSSKKPDKE------------K PIK-----EKDKGRWSPLKVSAQDKE------PPPLPP---------------------- ------------------------------------------------------------ ---------------------------------------LVVFNHLTPPPPDEHLDEDE- --HLVV----------------ALYDYAAMND---------------------------- ----RDLQMLK--------GEKL--QVLKG------------------------------ ---------------TGD-----WWLAK-----SLV------------------------ TGREGY--VPSNFVARVESL--EVE------R-WFFRSLGRKEA-------ERQ------ LLAPINKAGSFLIRESETSK----------GAFSLSVKDVT-TQG--------------- -------ELIKHYKIRS------------------------------------------- ---LDGGGYYISPRITFPSLQA------LVQHYS-------KKGDGLCQRLT--L----- -----PCVSP--------------A-----PQ----NP------WAQDEWEIPRQSLRL- -------------VRKLGSGQFGEVWMGYYK---------NNMK----VAVKTLKEG--T M--------SPEAFLGEANVM--KA--LQHERLVRLYAVVT----K-EPIYIVTEYMARG CLLDFL-KTD------EGSRLSLPRLIDMSAQIAEGMAYIE----------RMNSIHRDL RAANILVSEALCCKIADFGLARII-D--------SE-Y----------TA------QEGA KFPIKWTAPEAIHF---GVFT------IKADVWSFGVLLMEVVTYGR-VPYPGMS----N P-EVIRNL--------------------------------------------ERGYRMP- R-------PDT--CP--PE-LYRGVIAECWRSRPEERPTFE------------------- --------------------------F-LQSVL----EDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATERQYELQP------------------------------------- ------------------------------------------------------------ ----------------------------- >D_rerio_ENSDARP00000095291 ---MEHFQ---------------------------------------------------- ----------------------GAWKSVSSHGFGCKDSVF-------------------- -----------------------------------------------------EDSCMSP SILKTFP-YRRLSDDGRIPD-SKTSSTIRVFLPNKQRTV--------------------- -----VNVRAG------------------------------------------------- ---------------------------------------MTLRNCLIKALKVRGLQ---- --PECC----------------AVFKLQREHS-----------------------AKKLR MDWSTDSTSLV--------GEELLVEVLDHVPLTTHNFVRKTFLKLAFCDICQKFLLHGF RCQTCGYKFHEHCSTKVPTMCVDWSNIR-----QLLW----LFPTPGE------------ NGALTL--PPLSSRRMQN----SRL------SFSPYHRYSTPNA-------LNY------ ITPLPSPGVSLGHKVLSTSTP---------NVHMVSTTQPVDEAAYQ------------- -------EALR-HDE--------------------------------------------- ---------SGSPQNLSPTEW------------S-------KTPAPAHREKA--P----- ------SSN-----------------TQEKRIRPREKR------DSSYYWEIEATEVLL- -------------LSRIGSGSFGTVYKGKWH---------GD------VAVKILKVINPT P-------EQLQAFRNEVAVL--RK--TRHVNIVLFMGYMT----K-VKLAIVTQWCEGS SLYKHL-HVQ-------ETNFQMFQLMDIARQTAQGMDYLH----------AKNIIHRDM KSNNIFLHEGLTVKIGDFGLATVKAR--------WSGS----------HR------VEQP SGSILWMAPEVIRMQDNNPYS------FQSDVYSYGIVLYELMT-GE-LPYSMIG----N RDQVRGLV--------------------------------------------GRGYLSP- D--L-SKLYKS--CP--KA-MKR-LVSDCIQKTKEVVVFFF------------------- --------------------------Q-ILSSIELLQHSLP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KINRSASEPSLHRAT-HTEDMNVCTL-ALTSAFKSSVCVSGTAAEERV LTLLSDLLGFLSFYWLVVACHGELTCKQMVYSLYFNKIKLNTHTH--------------- ----------------------------- >T_rubripes_ENSTRUP00000007128 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCIKSKEEKG-----------PTM KYRPENSMMADPNATAASQTGHYGPD------PTQLQQNQVPSSSSGNVGVNFNHSITPF GGSSSAMTPF-------------------------------------------------- ---------------------------------------GGVSSSFTGPVSNSFSGAVSS GVTFFV----------------ALYDYEARTS---------------------------- ----DDLSFTK--------GDRF--QIINN------------------------------ --------------TEGD-----WWEAR-----SIT------------------------ TGRTGY--IPSNYVAPADSI--QAE------E-WYFGKMGRKDA-------ERL------ LLIPGNHRGTFLVRESETTK----------GAYSLSIRDWEEAKG--------------- -------DNVKHYKIRK------------------------------------------- ---LDSGGYYITTRVQFDALQK------LVKHYT-------EHADGLCHRLT--T----- -----VCPTV--------------K-----PQTQG---------LAKDAWEIPRESLRL- -------------EIKLGQGCFGEVWMGTWN---------GTTK----VAIKTLKTG--T M--------SPEAFLQEAQIM--KK--LRHDKLVPLYAVVS----E-EPIYIVTEYMAKG SLLDFL-KEG------DGKFLKLPLLVDMAAQIADGMAFIE----------RMNYIHRDL RAANILVGDNLVCKIADFGLARLIED--------NE-Y----------TA------RQGA KFPIKWTAPEAALY---GRFT------IKSDVWSFGILLTELVTKGR-VPYPGMV----N R-EVLEQV--------------------------------------------ERGYRMP- C-------PQG--CP--ES-LHE-MMKLCWKKDPDERPTFE------------------- --------------------------Y-LQSFL----EDYF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEPQYQPGENL----------------------------------- ------------------------------------------------------------ ----------------------------- >O_latipes_ENSORLP00000020461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FDNSVLQL------------------------------ ------------------------------------------------------------ ---------------------------------QEQDHEEVVSP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---GSCEHHGGECRPGHPHHPD--------------------DIKLHFHRAG--PGSGGF LEGLFGCLRP-------------VWNIIGKTYSTEYKL------QQQDMWEVPFEEISE- -------------LQWLGSGAQGAVFLGKFR--------SE--E----VAIKKVREQK-- --------------ETDIKHL--RK--LKHPNIISFKGVCT----QAPCYCIIMEYCAQG QLYEVL-RAGR--------KVTPRLLVDWATGIASGMNYLH----------LHKIIHRDL KSPNVLVTQADTVKISDFGTSKELSD--------KST-------------------KMSF AGTVAWMAPEVIRN---EPVS------EKVDIWSFGVVLWELLT-GE-IPYKDVD----S S-AIIWGV--------------------------------------------GSNSLHL- ------PVPST--CP--DG-FKI-LMKQTWQGKPRNRPSFR------------------- --------------------------Q-ILLHLDIASADILGTPQETYFKSQAEWREEVK KHFEKIKSEGTCIHRLDEE-----LIRRRRDELRHALDIREHYERKLERANNLYMELSAI MLQLEVREKELMKREQAVEKKYPGTYKRHLVRPIVRSNAVEKLIKKKGSISHKPGMPTTK KPDLLRSDVIPSLDPLPSPSPLSASPKVSTPPGKTRYRSKPRHRRANSKGSHNEFPAMLI PAAGISEDTQSLQEQPLHHHHHPPNEGQFLPLKGRVEAVVNCANNLRYFGPAAALRSPQT DHLQRRVSGSSPDLISTAMDADTRQRTSSTGSNAVTGAGAGSLCPCCQAHPFPGCLNCQE TPPTLNQPELPHYSLLNTQESTKPSLSVTNKDNVLDGVDAKK--AEPQHSVQPALTLPSA LPRILRPLRKGADESSEEEEGEVDSEVEYPRRQRTHRCMSSFKSYSTFSSENLSVSDGEE GNTSDHSHSGPLEKLSASQEEHLDELLSHTPDIPIDISTQSDGLSDKECAVRRVKTQISL GKLCSDEHSYENPLQFGDSDCDSSEAECSDATIRNNKVGAPSSW---------------- ----------------------------- >O_latipes_ENSORLP00000021875 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCACSTDSEEWLENLDDICEHCNC PIP-----PQSSKGKLSIYTDQLIQH------P--------------------------- ------------------------------------------------------------ ------------------------------------------SSHSPPLSPLPD------ --NIAL----------------AVYSYEPKHD---------------------------- ----GDLGFEK--------GDKL--KILNK------------------------------ --------------DDPE-----WYLAE-----SLT------------------------ TGQQGY--IPFNFIA-MTTM--ETE------P-WFFRDISRNDA-------MRL------ LLAPGNTQGSFLIRESETTK----------GSYSLSIRDLDHNAG--------------- -------EGVKHYRIRN------------------------------------------- ---LDSGGFYITAKISFNSLKE------LVQHYT-------READGLCSTLG--K----- -----PCQSR--------------A-----PQ----KP------WWHDEWEIPRESLKL- -------------LRRLGAGQFGEVWMGLYN---------NDSK----VAIKNLKMG--T M--------SVEAFLAEANMM--KN--LQHPRLVRLFAVVT----E-EPIYIVTEYMENG SLVDFL-KTQ------EGGNLPINTLIDMASQVADGMAFIE----------QRNYIHRDL RAANILVSHELICKVADFGLARLIED--------NE-Y----------TA------REGA KFPIKWTAPEAINF---GTFT------IKSDVWSFGILLTEIVTYGR-IPYPGMS----N P-EVIQNL--------------------------------------------ERGYRMP- K-------PEG--CP--DG-LYA-IMCHCWKETPDDRPTFE------------------- --------------------------Y-LKDVL----EDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ASTERQYH---------------------------------------- ------------------------------------------------------------ ----------------------------- >C_intestinalis_ENSCINP00000011940 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SSVSIPDRPAPPIPTPVSIR--------------------- ------------------------------------------------------------ -------------------------------------------------------EPVHQ EQEIYI----------------ALYDYGARAK---------------------------- ----NHLTIKK--------GDRM--IMLYK------------------------------ ---------------DGA-----WSVVRLLQPNRMN------------------------ SNTKGY--VPSNFIRRESLI--NSQ------PPWMFDTAVRSEA-------ITL------ LMQPCNQQGAFMVRRRADDR----------NEYALSVMNK-------------------- -------AKVHHFKIKK------------------------------------------- ---SSQG--YLMGGIEFITLDE------LVAFYK-------KNLVGDIARLG--S----- -----PCKQS--------------QMVVESPQTIGLSH------DIVDEWEIDRNSIQL- -------------GKKLGSGQFGEVHKGLWN---------KTTT----VAVKTMKSSD-S L--------NKEEFLKEARLM--KK--LHHPKLVQLFAVCT----QSEPFYIVTELMCNG ALLDYL-R--------EDLNLEEEVLIDMATQVATGMAYLE----------VKNYIHRDL AARNILVGKNNNCKVADFGLARLTQD--------DEIY----------QA------KVKA KIPIRWTAPEAITK---QQFS------IKSDVWSFGILLTEIIGKGR-VPYPGMD----N K-EVLEQL--------------------------------------------ERGYRME- R-------LEK--CS--ED-MYK-IMRDCWDIDPNERPSFE------------------- --------------------------I-LEIEL----SDF-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >H_sapiens_ENSP00000259089 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GLVSSKKPDKE------------K PIK-----EKDKGQWSPLKVSAQDKD------APPLPP---------------------- ------------------------------------------------------------ ---------------------------------------LVVFNHLTPPPPDEHLDEDK- --HFVV----------------ALYDYTAMND---------------------------- ----RDLQMLK--------GEKL--QVLKG------------------------------ ---------------TGD-----WWLAR-----SLV------------------------ TGREGY--VPSNFVARVESL--EME------R-WFFRSQGRKEA-------ERQ------ LLAPINKAGSFLIRESETNK----------GAFSLSVKDVT-TQG--------------- -------ELIKHYKIRC------------------------------------------- ---LDEGGYYISPRITFPSLQA------LVQHYS-------KKGDGLCQRLT--L----- -----PCVRP--------------A-----PQ----NP------WAQDEWEIPRQSLRL- -------------VRKLGSGQFGEVWMGYYK---------NNMK----VAIKTLKEG--T M--------SPEAFLGEANVM--KA--LQHERLVRLYAVVT----K-EPIYIVTEYMARG CLLDFL-KTD------EGSRLSLPRLIDMSAQIAEGMAYIE----------RMNSIHRDL RAANILVSEALCCKIADFGLARII-D--------SE-Y----------TA------QEGA KFPIKWTAPEAIHF---GVFT------IKADVWSFGVLLMEVVTYGR-VPYPGMS----N P-EVIRNL--------------------------------------------ERGYRMP- R-------PDT--CP--PE-LYRGVIAECWRSRPEERPTFE------------------- --------------------------F-LQSVL----EDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATERQYELQP------------------------------------- ------------------------------------------------------------ ----------------------------- >A_aegypti_AAEL004592-PA ---M-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------GNKCCSKRQDQELALSYPGGYKKGEN SFTSNMSGPKHSNGGGGSLDSRYTPD------PNRGQL---------------------I KGIPKGGVDII------------------------------------------------- ---------------------------------------RPRTTPLHPGLSTR------- --RIVV----------------ALYNYNAREE---------------------------- ----TDVSFVK--------GDRM--EVLDD------------------------------ --------------TESD-----WWRVV-----HLK------------------------ TRQEGL--IPWNFVAEDRSV--NSE------D-WFFENVSRKEA-------DKL------ LLAAENPRGTFLVRPSEHNP----------NGFSLSVKDWEESRG--------------- -------YHVKHYKIKP------------------------------------------- ---LDNGGYYIATNQTFPSLPA------LVLAYS-------KNALGLCHVLS--S----- -----PCPKP--------------Q-----PQVWDLGP------ELRDKWEINRNEIQL- -------------IRKLGHGNFGEVYYGKWR---------NNIE----VAVKTLREG--T M--------STQAFLQEAAIM--KK--FRHSRLVALYAVCS----KEEPIYIVQEYMSKG SLLDYL-RTG------DGQFLQFEDLIYIAAQVASGMEYLE----------LKQLIHRDL AARNVLIGENNVAKICDFGLARVIAD--------DE-Y----------CP------KQGS RFPVKWTAPEAIVY---GKFS------IKSDVWSYGILLMELFTYGQ-VPYPGMH----S R-EVIEQI--------------------------------------------ERGYRMP- K-------PTNHTLP--DD-IYS-LMLKCWDAIPEKRPTFE------------------- --------------------------F-LNHYF----QNFT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VTSEVPYREV---------Q---------------------------- --------------------------------------------D--------------- ----------------------------- >T_rubripes_ENSTRUP00000008303 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCVQCKDKKA-----------TKL TD------NRETNHSLGAARYHYGAD------P---MPQHYPSFGVTAIPNYNNFHTPVG QGMAVFG----------------------------------------------------- ---------------------------------------GVSTSSHSGTLRTHSGTGLAK RVTLFV----------------ALYDYEARTE---------------------------- ----DDLSFRK--------GEKF--QIINS------------------------------ --------------SEGD-----WWEAR-----SLT------------------------ TGGNGY--IPSNYVAPVDSI--QAE------D-WYFGKLGRKDA-------ERQ------ LLSTSNPRGTYLIRESETTK----------GAFSLSIRDWDDMKG--------------- -------DHVKHYKIRK------------------------------------------- ---LDSGGYYITTRAQFETLQQ------LVQHYS-------DRAAGLCCRLV--V----- -----PCHKG--------------M-----PRLADLSI------KTKDVWEIPRESLQL- -------------IKRLGNGQFGEVWMGTWN---------GTTK----VAVKTLKPG--T M--------SPESFLEEAQIM--KK--LRHDKLVQLYAVVS----E-EPIYIVTEYMGKG SLLDFL-KDG------EGRMLKLPNLVDMAAQVAAGMAYIE----------RMNYIHRDL RSANILVGDNLTCKIADFGLARLIED--------NE-Y----------TA------RQGA KFPIKWTAPEAALY---GKFT------IKSDVWSFGILLMELVTKGR-VPYPGMN----N R-EVLEQV--------------------------------------------ERGYRMP- C-------PQE--CP--NS-MHE-LMLQCWKRDAEERPTFE------------------- --------------------------Y-LQAFL----EDYF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEPQYQPGDNL----------------------------------- ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MIKC------------------------------ -----------------------WS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GNADARPCFLGDLEG- -------------LQQVGRGGFGTVYRGWSR--------SLNME----VALKTFQRAQS- --------------QNEREVM--EK--ASNPFVILLLGMYERQEGEVSEHGLVMEYVPNG SLRSLF-DTMD---------VPWALRFQMLHQVALGMNYLH--------TLDPPIIHRDL KPSNVLLNKHFDVKITDFGLSKIAGA--------TTSA------------------TPYF AGTPSYMAPEALTDLN-YKPT------MAFDVYSFGIMIWAVLS-GE-EPFPNAH----P A-LIQLHI--------------------------------------------PNGQRPSL EVLDHLSHIKM--VP--EA--KE-LMIKCWSGNADARPSFL------------------- --------------------------E-CSHATKLMFELYS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SEIKGAIRTMEDHTHQLQN------------------------- ------------------------------------------------------------ ----------------------------- >X_tropicalis_ENSXETP00000046976 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SGAILGRSETKECVYY------------------------------ --------------------NANWEKDKTNPNGTEICYG--------------------- ---------------------------------DNDKRRHCFATWKNISGSIEIVKQGCW LDDMNCYDKSDCTERKESPDVFFCCCEGNTCNERFYHSPEMEVTQ--------------- ------------------------------------------------------------ ---PTSNPVPTKPPLFNTLLYSLVPIMVVAVIVLFSFWMYRHHKLAYPPVLV--PTQDPG --------------------------------------------PPPPSPLLGLKPLQL- -------------LEVKARGRFGCVWKAQLL--------NE--T----VAVKIFPIQDKL S----------WQNEYEIYNL--PG--MKHENILQFIGAEKRGTNLDTDLWLITAFHEKG SLTDYL-KANV---------VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAVAHRDI KSKNILLKNSLTACIADFGLALKFEA--------GKSA----------GD------THGQ VGTRRYMAPEVLE----GAINFQRDAFLRIDMYAFGLVLWELAS-RC-TASDG------P VDEYMLPF---------EEEV--------------------------------------- -----GQHPSL------ED-MQE------VVVHKKKRPILR------------------- --------------------------E-CWQKHAGMAMLCE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TIEECWDHDAEARLSAGCVEERIIQMQKLTNIITTEDIVTVVTMVTNV DFPPKESSL--------------------------------------------------- ----------------------------- >T_nigroviridis_ENSTNIP00000019431 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ADGLCQRLF--A----- -----PCKPK--------------A-----FQ----QP------WAQDEWEIPRDTLKM- -------------VKKLGAGQFGEVWMGYYK---------NTQK----VAIKTLKEG--T M--------EPAAFLEEANLM--KQ--LQHERLVRLHAVVT----K-EPILIVTEFMVNG SLLDFL-KSD------AGKKLKVNKLIDMAAQIAEGMAYIE----------VKNYIHRDL RAANILVSETLHCKIADFGLARIIE---------SE-Y----------TA------QEGA KFPIKWTAPEAINF---GTFS------IKSDVWSFGILLTEIVTFGR-IPYPGMT----N P-EVIRNL--------------------------------------------ERLYRMP- R-------PEG--CP--AE-LYE-VMMTCWKEKPEERPTFE------------------- --------------------------F-LQNIL----NDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IATEGQYEMQP------------------------------------- ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000004157 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------MDPA MKLAFGVFVISCSSAGAILGHSDAQRCVHS------------------------------ ---------------SFSPASSSWLEGQGNISGVVTCSG--------------------- ---------------------------------EKNKKLHCFATWKNLSGVVQVVQQGCW LDDVNCYDRTECEENREALGVFFCCCEGSLCNKKFSYRPISQSQIT-------------- ------------------------------------------------------------ ---TTTKPVTARAQLLTTLMYSLLPVMAVGAVLLFSLWLYRQHKRAYPPVLV--PTQEPH --------------------------------------------PPPPSPSLSQRPLQL- -------------LEVKGRGRFGCVWKAQLL--------SD--V----VAVKIFPLQDKQ S----------WQNEYEIFTL--NG--MGHENVLQFIGAERRGSHVDMELWLITAYHEKG CLTDYL-KADV---------LSWSQVCVIAQSMSRGLAYLHEDVP----GHKPAIAHRDV KSKNVLLKSNLTACIADFGLALRFEA--------GRSP----------GE------THRQ VGTRRYMAPEVLE----GTITFHRDAFLRIDVYALALVLWELAS-RC-TAVDEQG----P VDEYMLPF---------EEEV--------------------------------------- -----GQHPSL------ED-MQE------VVVHNKLRPPLR------------------- --------------------------E-CWQKHA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CHY PIV-----PLDGKGKLPIRNGSEVRD------PL-------------------------- ------------------------------------------------------------ ---------------------------------------VTYEGCNPPASPLQD------ --NLVI----------------ALHSYEPSHD---------------------------- ----GDLGFEK--------GEQL--RILEE------------------------------ ---------------SGE-----WWKAQ-----SLT------------------------ TGQEGF--IPFNFVAKANSL--EPE------P-WFFKNLSRKDA-------ERQ------ LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG--------------- -------EVVKHYKIRN------------------------------------------- ---LDNGGFYISPRITFSGLHE------LVRHYT-------NASDGLCTRLS--R----- -----PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--S M--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG SLVDFL-KTP------SGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDL RAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----N P-EVIQNL--------------------------------------------ERGYRMV- C-------PDN--CP--EE-LYQ-LMRLCWKERPEDRPTFD------------------- --------------------------Y-LRSVL----EDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQPQP------------------------------------- ------------------------------------------------------------ ----------------------------- >E_caballus_ENSECAP00000020913 ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCSCSSNPEDDWMENIDVCENCHY PIV-----PLDGKATLPMRNGSEVRD------PL-------------------------- ------------------------------------------------------------ ---------------------------------------VTYEGSNPPASPLQD------ --NLVI----------------ALHRYEPSHD---------------------------- ----GDLGFEK--------GEQL--RILEQ------------------------------ ---------------SGE-----WWKAQ-----SLT------------------------ TGQEGF--IPFNFVAKANSL--EPE------P-GPRDDGPSLSA-------LRSW----- LLAPGNTHGSFLIRESESTA----------GSFSLSVRDFDQNQG--------------- -------EVVKHYKIRN------------------------------------------- ---LDKGGFYISPRITFPGLHE------LVRHYT-------NASDGLCTRLS--R----- -----PCQTQ--------------K-----PQ----KP------WWEDEWEVPRETLKL- -------------VERLGAGQFGEVWMGYYN---------GHTK----VAVKSLKQG--S M--------SPDAFLAEANLM--KQ--LQHQRLVRLYAVVT----Q-EPIYIITEYMENG SLVDFL-KTS------TGIKLTINKLLDMAAQIAEGMAFIE----------ERNYIHRDL RAANILVSDTLSCKIADFGLARLIED--------NE-Y----------TA------REGA KFPIKWTAPEAINY---GTFT------IKSDVWSFGILLTEIVTHGR-IPYPGMT----N P-EVIQNL--------------------------------------------ERGYRMV- R-------PDN--CP--EE-LYQ-LMMLCWKERPEDRPTFD------------------- --------------------------Y-LRSVL----EDFF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATEGQYQPQP------------------------------------- ------------------------------------------------------------ ----------------------------- >T_rubripes_ENSTRUP00000030627 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPLNTALSVDSTRSEGQHFENSVLQL------------------------------ ------------------------------------------------------------ ---------------------------------QEQDQDEAVSP---------------- ------------------------------------------------------------ ------------------------------------------------------------ -----ASYHSEEGKQGHHHQPE--------------------DIKLHFHRAG--PGSGGF LEGLFGCLRP-------------VLNIIGKTYSTEYKL------QQQDMWEVPFEEISE- -------------LQWLGSGAQGAVFLGKFR--------SE--E----VAIKKVREQK-- --------------ETEIKHL--RK--LKHPNIISFKGVCT----QAPCYCIIMEYCAQG QLYEVL-RAGR--------KVTPRMLVDWASGIASGMNYLH----------LHKIIHRDL KSPNVLVTHNDTVKISDFGTSKELSD--------KST-------------------KMSF AGTVAWMAPEVIRN---EPVS------EKVDIWSFGVVLWELLT-GE-IPYKDVD----S S-AIIWGV--------------------------------------------GSNSLHL- ------PVPST--CP--DG-FKI-LMKQTWQAKPRNRPSFR------------------- --------------------------Q-ILLHLDIASADVLGAPQETYFKCQSEWREEVK KHFEKIKSEGTCIHRLDEE-----LIRRRRDELRHALDIREHYERKLERANNLYMELSAI MLQLEVREKELMKREQAVEKKYPGTYKRHLVRPIVRSNAVEKLIKKKGSLPHKPGMPTAK RPDLLRSDGIPSVDPLPSPSLLTASPKVSTPPGKARYRSKPRHRRANSKGSHSEFAGVLK PVAGALEGTQSLKD----HHHHLPTQGPFLPLKGREEAVVNCANNLRYFGPAAALRSPQT DHMQGRVSGSGPDLISTAVSADTRQQTSSASSNPV--PGSASLCPCCQTHPFPGCLKCQE TSPAFERADLPYNSQLPTEDGT-LRLGSTNDDPASGGEATKRPESEEQEAHQQTLPLPTP LPRTLRPLRKGGDESSEEEEGEVDSEVEFPRRQRPHRCMSSFQSCSTFSSENLSVSDGEE GNTSDHSHSGPLEGLSASQEEHLDELLSHTPDIPIDISTQSDGLSDKECAVRRVKTQISL GKLCSDEHSYENPLQFGDSDCDSSEAECSDATIRNNKVGAPSSW---------------- ----------------------------- >T_nigroviridis_ENSTNIP00000020756 AGRM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------GCIKSRLDGG-----------VSK GVE-----EKSSPQTVRTQLARYVRD------PTSDINHNI------------------- ------------------------------------------------------------ ------------------------------------------NNSLLPGQRFQTLEEKG- VEKIVI----------------ALYPYEALHP---------------------------- ----DDLGFKK--------GERM--KILEE------------------------------ ---------------RGE-----WWRAK-----SLS------------------------ TNREGF--IPSNYVGQADTM--ETE------D-WFFKDISRKDA-------ERQ------ LLAPANRAGSYLIRESETAK----------GSFSLSVRDVDDGGT--------------- -------DLVKHYKIRL------------------------------------------- ---LDNGGYYISPKISFTDISS------MIKHYH-------SKADGLCRKLD--R----- -----PCVKP--------------K-----AE----KP------WDKDAWEISKDSIRM- -------------VKRLGAGQFGEVWMAYYN---------NITR----VAVKTLKPG--T M--------TVEAFMDEANLM--KK--LQHDRLVRLYAVVT----KTEPIYIITEYMANG SLLDFL-KSD------LGCSLQIPKLIDFSAQIAEGMAYIE----------RRNYIHRDL RAANVLVSECLLCKIADFGLARVIED--------DE-Y----------SA------REGA KFPIKWTAPEAINY---GSFT------IKSDMWSFGVLLYEIITYGK-IPYPGMT----K G-EVISSI--------------------------------------------QRGYRMP- Q-------PDS--CP--SE-LYH-MMLDCWKDKPDARPTFE------------------- --------------------------Y-MQSVL----NDFY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TATESQYQQQP------------------------------------- ------------------------------------------------------------ -----------------------------