10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a MDANDYPRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSESEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSRRV H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA MAGREQYQVKDRDDTMGLTIVFDSGIICHPYPGQYPGSLQGHPQHGTGPPPLHSKPNFSSSPLGQGPSTVPPSHTNHVHHQGMHGPSVTGQSGMATPQLDLGPSNPVPHHHHHHPNHMGG C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ----------------------------------------------------------------------------------------------------------MS------------ M_mulatta_ENSMMUP00000010949 ----------------------------------------------------------------------------------------------------------MS------------ P_troglodytes_ENSPTRP00000034602 ----------------------------------------------------------------------------------------------------------MS------------ C_familiaris_ENSCAFP00000008270 ----------------------------------------------------------------------------------------------------------MS------------ M_musculus_ENSMUSP00000033939 ----------------------------------------------------------------------------------------------------------MS------------ R_norvegicus_ENSRNOP00000025851 ----------------------------------------------------------------------------------------------------------MS------------ B_taurus_ENSBTAP00000049055 ----------------------------------------------------------------------------------------------------------MS------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ----------------------------------------------------------------------------------------------------------MS------------ E_caballus_ENSECAP00000003662 ----------------------------------------------------------------------------------------------------------MS------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ----------------------------------------------------------------------------------------------------------MS------------ G_gorilla_ENSGGOP00000006628 ----------------------------------------------------------------------------------------------------------MS------------ A_carolinensis_ENSACAP00000012680 -----------------------------------------------------------------------------------------------------------A------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ----------------------------------------------------------------------------------------------------------MT------------ O_latipes_ENSORLP00000003067 ----------------------------------------------------------------------------------------------------------MN------------ T_nigroviridis_ENSTNIP00000019003 ----------------------------------------------------------------------------------------------------------MN------------ G_aculeatus_ENSGACP00000005440 ----------------------------------------------------------------------------------------------------------MN------------ T_rubripes_ENSTRUP00000041917 ----------------------------------------------------------------------------------------------------------MN------------ G_gallus_ENSGALP00000005196 --------------------------------------------------------------------------------------------MERGAERGPPPAPGGV------------ T_rubripes_ENSTRUP00000022821 ----------------------------------------------------------------------------------------------------------ME------------ R_norvegicus_ENSRNOP00000034134 ----------------------------------------------------------------------------------------------------------ME------------ P_troglodytes_ENSPTRP00000055512 ----------------------------------------------------------------------------------------------------------ME------------ H_sapiens_ENSP00000359424 ----------------------------------------------------------------------------------------------------------ME------------ M_mulatta_ENSMMUP00000024306 ----------------------------------------------------------------------------------------------------------ME------------ D_rerio_ENSDARP00000013115 ----------------------------------------------------------------------------------------------------------ME------------ C_familiaris_ENSCAFP00000014093 ----------------------------------------------------------------------------------------------------------ME------------ B_taurus_ENSBTAP00000009985 --------------------------------------------------------------------------------------------RNSGGASGRSPSRPME------------ M_musculus_ENSMUSP00000026217 ----------------------------------------------------------------------------------------------------------ME------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ----------------------------------------------------------------------------------------------------------ME------------ G_aculeatus_ENSGACP00000005520 ----------------------------------------------------------------------------------------------------------ME------------ P_pygmaeus_ENSPPYP00000002975 ----------------------------------------------------------------------------------------------------------ME------------ X_tropicalis_ENSXETP00000038296 ----------------------------------------------------------------------------------------------------------ME------------ T_nigroviridis_ENSTNIP00000014802 ----------------------------------------------------------------------------------------------------------ME------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ----------------------------------------------------------------------------------------------------------ME------------ T_rubripes_ENSTRUP00000036336 ----------------------------------------------------------------------------------------------------------ME------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ----------------------------------------------------------------------------------------------------------ME------------ T_nigroviridis_ENSTNIP00000019642 ----------------------------------------------------------------------------------------------------------ME------------ T_guttata_ENSTGUP00000005662 ----------------------------------------------------------------------------------------------------------MS------------ G_gorilla_ENSGGOP00000008804 ----------------------------------------------------------------------------------------------------------ME------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ----------------------------------------------------------------------------------------------------------MM------------ A_gambiae_AGAP009166-PA ----------------------------------------------------------------------------------------------------------MI------------ A_aegypti_AAEL010548-PA -----------------------------------------------------------------------------------------------------------M------------ D_melanogaster_FBpp0082690 ----------------------------------------------------------------------------------------------------------MI------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 -------------------------------------------------------------------------------------------------MGNAPAKKDT------------- T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a SANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSGIHKKSI H_sapiens_ENSP00000366488 -------------------------------------------------------------------------------------------------MGNAPAKKDT------------- P_troglodytes_ENSPTRP00000035898 -------------------------------------------------------------------------------------------------MGNAPAKKDT------------- A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 -------------------------------------------------------------------------------------------------MGNAAAKKD-------------- A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ----------------------------------------------------------------------------------------------------AAIFTHN------------- G_aculeatus_ENSGACP00000024909 -------------------------------------------------------------------------------------------------MGNAPTARKG------------- P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 -----------------------------------------------MSVDNSLGILDLSSGKESEKTAMTAANKENDPDSHFTGTIVTTGATAQPATPTTSNATALP------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 -------------------------------------------------------------------------------------------------YAHNHTLSLS------------- T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ---------------------------------------------------------------------------------------------------NAAQQPSN------------- M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 -------------------------------------------------------------------------------------------------MGNTPAAKRG------------- A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 -------------------------------------------------------------------------------------------------MGNAAAAKKG------------- T_rubripes_ENSTRUP00000013710 -------------------------------------------------------------------------------------------------MGNAPTARKG------------- P_troglodytes_ENSPTRP00000018062 -------------------------------------------------------------------------------------------------M--------A------------- H_sapiens_ENSP00000309591 -------------------------------------------------------------------------------------------------MGNAAAAKKG------------- T_nigroviridis_ENSTNIP00000013350 -------------------------------------------------------------------------------------------------MGNTPTTKKG------------- T_rubripes_ENSTRUP00000032222 -------------------------------------------------------------------------------------------------MCDRKSSRRHA------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA APGAASSHQHQPQQQQHLPPHNQQQHAMPPGSNGPMNGPGQFPGHHQPTIHHKMPSPASITGSTAEPNVNSMNNNNPSTKANSRASSSSGGNISVAHSTTSSVQTGGA------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 -------------------------------------------------------------------------------------------------MGNTPTAKKG------------- B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a AVEGTEIALRDLRNEALQFIKEIYPEKGCSSLEDYILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGSCPQNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYH H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a KRCASKIPNNCNGSKQRRPSAIPLSPSNSNILNLNERRHSRRESCLEALDAARPSSTLGGAATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVPHTFQVHS H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a YKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGNTKASQFFLGSQADDGASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSGSPGPVVSFAANALSNMPDDDVIS H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010949 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034602 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000008270 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000033939 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025851 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000049055 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020804 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000001111 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003662 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000012792 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005924 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000006628 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012680 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000036619 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003067 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019003 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005440 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000022821 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000034134 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000055512 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000359424 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000024306 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013115 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000014093 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000009985 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026217 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000013213 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000005520 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002975 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014802 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000011973 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008884 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000036336 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000003934 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000011761 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019642 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a SESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDENTTRYYKEIPLNEILNVSMSPPDKTADYLFEIRTGVCVYFISGSPSDEKGSSLDAQSWTTA H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH M_mulatta_ENSMMUP00000010949 -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH P_troglodytes_ENSPTRP00000034602 -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH C_familiaris_ENSCAFP00000008270 -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH M_musculus_ENSMUSP00000033939 -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ATGEQIAIKQC-----RQ-ELSP-KNR-----DRWCLEIQIM-RRLNH R_norvegicus_ENSRNOP00000025851 -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGGFGNVIRWHNQ--VTGEQIAIKQC-----RQ-ELSP-KNR-----DRWCLEIQIM-RRLNH B_taurus_ENSBTAP00000049055 -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH P_pygmaeus_ENSPPYP00000020804 -------------------------------------------------------------------------------------------------------------SVFLL-PRLTH O_anatinus_ENSOANP00000001111 -----------W-----------PPS-------------LQTQT--CGVWEMKERLGTGGFGNVIRWHNK--ETGEQIAIKQC-----RQ-ELST-RNR-----ERWCLEIQIM-RRLNH E_caballus_ENSECAP00000003662 -----------W-----------SPS-------------LPTQT--CGAWEMKERLGTGGFGNVIRWHNQD-QNGSSVASVQC-----RQADISI-RSF-----QPWTFDSRAL-VLLNH M_domestica_ENSMODP00000012792 ---------------------------------------------------------------------Q--ETGEQIAIKQC-----RQ-ELSL-RNR-----ERWCLEIQIM-RRLNH G_gallus_ENSGALP00000005924 -----------R-----------PPA-------------LQAQT--CGPWEMKERLGTGGFGNVIRWHNK--ETGEQVAIKQC-----RQ-ELSP-RNR-----DRWALEIQIM-KRLNH G_gorilla_ENSGGOP00000006628 -----------W-----------SPS-------------LTTQT--CGAWEMKERLGTGGFGNVIRWHNQ--ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLTH A_carolinensis_ENSACAP00000012680 -----------P-----------PPL-------------QPLAS--CGAWEMRERLGTGGFGNVIRWQHR--ETGEQIAIKQC-----RQ-ELSL-RNR-----ERWCLEIQIM-KRLNH O_cuniculus_ENSOCUP00000006175 ------------------------------------------------------------------------ETGEQIAIKQC-----RQ-ELSP-RNR-----ERWCLEIQIM-RRLNH X_tropicalis_ENSXETP00000036619 -----------HQDASPGRAGWAPPP-------------SHTQI--CGPWEMKERLGTGGFGYVLRWIHQ--DTGEQVAIKQC-----RQ-ELSP-KNR-----ERWCLEIQIM-KKLNH O_latipes_ENSORLP00000003067 -----------R-----------VPL-------------QQPQT--CGPWELKERLGTGGFGNVTRWQNK--DTEEQIAIKQC-----RQ-ELSE-RNK-----ERWKLEIQIM-KRLNH T_nigroviridis_ENSTNIP00000019003 -----------R-----------VPL-----------QQQQQQC--CGLWELRERLGNGGFGNVTRWQNK--ETEEQIAIKQC-----RQ-ELSE-RNK-----ERWCLEIEII-KRLDH G_aculeatus_ENSGACP00000005440 -----------R-----------VTL--------------QQQS--CGSWELKERLGTGGFGNVTRWQNK--DTEEQISIKQC-----RQ-ELSE-RNK-----ERWVLEIQIM-KRLDH T_rubripes_ENSTRUP00000041917 -----------R-----------VPL-------------QQQQS--CGLWELKERLGTGGFGNVTRWQNK--ETEEQIAIKQC-----RQ-ELSE-RNK-----ERWCLEIQII-KRLDH G_gallus_ENSGALP00000005196 -----------A-----------LRG-------------QPAGG--CGPWEMRDRLGTGGFGNVCLYQHQ--DTGARVAIKSC-----RL-ELSV-KNK-----DRWCHEIDIM-KKLNH T_rubripes_ENSTRUP00000022821 -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGGFAHVYLYQHR--ETNEKLAVKMC-----RL-ELTP-RNK-----DRWSREIQIM-KKLNH R_norvegicus_ENSRNOP00000034134 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVSLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH P_troglodytes_ENSPTRP00000055512 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH H_sapiens_ENSP00000359424 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH M_mulatta_ENSMMUP00000024306 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH D_rerio_ENSDARP00000013115 -----------K-----------PPF-------------RQNQV--CGSWVMKERLGTGGFGHVYLYQNQ--ETSEKIAVKLC-----RL-ELNS-KNK-----DRWSREIQIM-KKLKH C_familiaris_ENSCAFP00000014093 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDVKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH B_taurus_ENSBTAP00000009985 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH M_musculus_ENSMUSP00000026217 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVSLYQHR--ELDLKIAIKSC-----RL-ELSS-KNR-----ERWCHEIQIM-KKLDH M_domestica_ENSMODP00000013213 -------------------------------------------------WEMRERLGTGGFGNVCLYQHR--ELGNKIAIKSC-----RL-ELSA-KNK-----DRWCHEIQIM-KKLNH T_guttata_ENSTGUP00000004836 -----------------------------------------------GPWEMRDRLGTGGFGNVCLYQHQ--DSGDRVAIKSC-----RL-ELSV-KNK-----DRWCHEIDIM-KKLNH O_latipes_ENSORLP00000016017 -----------K-----------PPF-------------RQNVN--CGDWEMKERLGMGGFAHVYLYQHC--ATNEKLAVKMC-----RL-ELTP-RNR-----DRWSREIQIM-KKLNH G_aculeatus_ENSGACP00000005520 -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGGFGHVYLYQHH--KTNEKLAVKMC-----RL-ELTP-RNK-----DRWSREIQIM-KKLNH P_pygmaeus_ENSPPYP00000002975 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH X_tropicalis_ENSXETP00000038296 -----------K-----------PPV-------------QHGAV--CGPWDMKDRLGTGGFGNVCLYQNR--ETGELKAIKSC-----RL-ELSM-KNK-----ERWCQEIQIM-KRLNH T_nigroviridis_ENSTNIP00000014802 -----------K-----------PPF-------------RQNQN--CGDWELKERLGMGGFGHVYLYQHR--ETNEKLAVKMC-----RL-DLTP-KNK-----DRWSREIQIM-KKLNH A_carolinensis_ENSACAP00000011973 ----------------------------------------------------------------------------KLAIKSC-----RL-ELSV-KNK-----DRWCHEIQIM-KKLNH E_caballus_ENSECAP00000005937 ------------------------------------------------------------------------ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH G_aculeatus_ENSGACP00000008884 -----------R-----------TPL-------------RHNQM--CGSWEMKERLGTGGFGHVYLYQHL--ESGEKIAVKLC-----RL-ELNS-KNK-----DRWGREIQIM-KKLNH T_rubripes_ENSTRUP00000036336 -----------R-----------FAL-------------KQSQL--CGSWEMKERLGMGGFGHVYLYQHLDQESGEKMAVKLC-----RL-ELNS-KNK-----ERWSREIQIM-KKLKH O_anatinus_ENSOANP00000003934 ---------------------------------------------------------------------Q--DLGDKIAIKAC-----RQ-ELSA-KNK-----DRWCHEIQIM-KKLQS O_latipes_ENSORLP00000011761 -----------R-----------SAL-------------KQGQL--FGSWETKERLGMGGFGHVYLYQHV--ETGVKIAVKHC-----RL-DLSA-KNK-----ERWSREIQIM-SKLNH T_nigroviridis_ENSTNIP00000019642 -----------R-----------FAL-------------KQSQL--CGSWEMKERLGMGGFGHVYLYQHL--ESGEKMAVKLC-----RL-ELNS-KNR-----ERWSREIQIM-KKLKH T_guttata_ENSTGUP00000005662 -----------R-----------PPA-------------LQALT--CGPWEMRERLGTGGFGNVIRWHNK--ETGEQVAIKQC-----RQ-ELSP-RNR-----DRWALEIQIM-KRLNH G_gorilla_ENSGGOP00000008804 -----------R-----------PPG-------------LRPGA--GGPWEMRERLGTGGFGNVCLYQHR--ELDLKIAIKSC-----RL-ELST-KNR-----ERWCHEIQIM-KKLNH T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ------------------------------------------------------------------------ELDLKIAIKSC-----RL-ELSS-KNR-----ERWCHEIQIM-KKLNH A_aegypti_AAEL003245-PA -----------A------------QS-------------EDPPF--IGDWHREKRLGSGGFGFVTLWKNH--KTNEMVAIKKCHILLDKS-EMTD-KNC-----ERWCNEVSLMMNKVRN A_gambiae_AGAP009166-PA -----------K------------PF-------------EDPPQ--IGEWCREKRLGNGGFGVVTLWRNK--QTQQAVAIKKFHILQDRS-EITD-KHC-----ERWRNEVKLMTETVQN A_aegypti_AAEL010548-PA -----------A------------QS-------------EDPPF--IGDWHREKRLGSGGFGFVTLWKNH--KTNEM-----CHILLDKS-EMTD-KNC-----ERWCNEVSLMMNKVRN D_melanogaster_FBpp0082690 -----------TVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGGFGLVIHWRNR--TTGREIATKHI-----KE-MGALSADQQVKLSERWNKELNWSRQFKNF T_rubripes_ENSTRUP00000005087 ---------------------------------------MASTP--NYLWSLQDVLGQGATASVYKARNK--KSGELVAVKVF-----NT-MSYN-RPH-----DVQMREFEML-RKLNH D_rerio_ENSDARP00000014302 ---------------------------------------MTSTA--NYLWSQEDILGQGATANVYKARNK--KTGELVAVKVF-----NL-VSYN-RPY-----EVQMREFEVL-QLLNH D_rerio_ENSDARP00000074566 ---------------------------------------MTSTA--NYLWSQEDILGQGATANVYKARNK--KTGELVAVKVF-----NL-VSYN-RPY-----EVQMREFEVL-QLLNH T_nigroviridis_ENSTNIP00000010090 --------------------------------------MVASTP--NYLWSLQDVLGQGATANVYKARNK--KSGELVAVKVF-----NT-VSYN-RPH-----DVQMREFEML-RKLNH B_taurus_ENSBTAP00000046540 ---------------------------------------MQSTV--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-ASYL-RPR-----EVQVREFEVL-RKLNH P_pygmaeus_ENSPPYP00000000308 ---------------------------------------MQSTA--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH E_caballus_ENSECAP00000000587 ---------------------------------------MQSTV--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-ASYM-RPR-----EVQVREFEVL-RKLNH H_sapiens_ENSP00000356087 ---------------------------------------MQSTA--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH X_tropicalis_ENSXETP00000015947 ---------------------------------------MQSTA--NHLWLLSDILGQGATANVYRGRNK--KTGDLYAVKVF-----NN-LSFL-RPA-----DVQMREFEVL-KKLNH A_carolinensis_ENSACAP00000012863 ---------------------------------------MQSTL--NYLWKTDDVLGQGATASVYKARNK--ISGELVAVKVF-----NS-VSYL-RPQ-----EVQIREFEVL-RKLNH M_mulatta_ENSMMUP00000038190 ---------------------------------------MQSTA--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-TSYL-RPR-----EVQVREFEVL-RKLNH G_aculeatus_ENSGACP00000000783 ---------------------------------------MQSTT--NYLWLISDLLGQGATANVYRGRHK--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH C_familiaris_ENSCAFP00000035372 ---------------------------------------MQSTI--NYLWHTDDLLGQGATASVYKARNK--KSGELVAVKVF-----NT-ASYL-RPR-----EVQVREFEVL-RKLNH M_domestica_ENSMODP00000002458 ---------------------------------------MQSTA--NYLWHTDDLLGQGATASVYRARNK--KSGELVAVKVF-----NN-ASYL-RPR-----EVQVREFEVL-RKLKH T_nigroviridis_ENSTNIP00000005945 ---------------------------------------MQSTT--NYLWLISDLLGQGATANVYRGRHK--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH M_musculus_ENSMUSP00000054126 ---------------------------------------MQSTT--NYLWHTDDLLGQGATASVYKARNK--KSGEVVAVKVF-----NS-ASYR-RPP-----EVQVREFEVL-RRLNH T_guttata_ENSTGUP00000006693 ---------------------------------------MQSTS--NYLWLLSDILGQGATANVFRGRQK--KTGDLYAVKVF-----NS-ISFL-RPV-----DVQMREFEVL-KKLNH A_carolinensis_ENSACAP00000003243 ---------------------------------------MQSTS--NYLWLLSDILGQGATANVFRGRHK--KTGDLYAVKVF-----NN-FSFL-RPV-----DVQMREFEVL-KKLNH R_norvegicus_ENSRNOP00000030127 ---------------------------------------MQSTT--NYLWHTDDLLGQGATANVYKARNK--KSGEVVAVKVF-----NS-ASYR-RPP-----EVQVREFEVL-RRLDH O_cuniculus_ENSOCUP00000010441 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH E_caballus_ENSECAP00000018587 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH M_mulatta_ENSMMUP00000010063 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH P_troglodytes_ENSPTRP00000008798 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH P_pygmaeus_ENSPPYP00000005386 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH H_sapiens_ENSP00000329967 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH C_familiaris_ENSCAFP00000000505 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH O_anatinus_ENSOANP00000008566 ---------------------------------------MQSTA--NYLWHTDDILGQGATASVYKARNK--KSGELVAVKVF-----NN-ASYH-RPP-----EVQVREFEVL-RKLKH G_gallus_ENSGALP00000015982 ---------------------------------------MQSTS--NYLWLLSDILGQGATANVFRGRHK--KTGDLYAVKVF-----NS-ISFL-RPV-----DVQMREFEVL-TKLNH M_musculus_ENSMUSP00000020316 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLYAVKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH G_aculeatus_ENSGACP00000000485 --------------------------------------MTASTA--NYLWSLQDVLGQGATASVYKARNK--RLGELVAVKVF-----NS-VSYN-RPH-----EVQMREFEML-RRLKH D_melanogaster_FBpp0080920 ------------------------------------MSFLRGSV--SYVWCTTSVLGKGATGSVFQGVNK--ITGESVAVKTF-----NP-YSHM-RPA-----DVQMREFEAL-KKVNH O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------RSGELVAVKVF-----NV-LSYN-RPH-----DVQMREFEML-RKLNH G_gallus_ENSGALP00000021757 ---------------------------------------MQSTP--NYLWSTDDLLGQGATACVYKARSK--KSGELVAVKVF-----NK-ASYL-RPQ-----EVQMREFEML-RKLNH A_aegypti_AAEL005359-PA -----------------------------------MNSFLRGST--NYVWCTTSVLGKGATGAVFQGVNK--HNGEPVAVKTF-----NQ-LSHM-RPP-----DVQMREFEVL-RKVKH B_taurus_ENSBTAP00000023134 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLFAIKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH T_guttata_ENSTGUP00000001142 --------------------------------------------------------------CLFLLFSQ--KSGELVAVKVF-----NN-ASYL-RPQ-----EVQMREFEML-RKLNH A_gambiae_AGAP009565-PA -----------------------------------MNSFLRGSM--NYVWCTTSVLGKGSTGAVFQGVNK--HNGEPVAVKTF-----NQ-LSHM-RPQ-----DVQMREFEVL-RKVNH R_norvegicus_ENSRNOP00000009260 ---------------------------------------MQSTS--NHLWLLSDILGQGATANVFRGRHK--KTGDLYAVKVF-----NN-ISFL-RPV-----DVQMREFEVL-KKLNH C_intestinalis_ENSCINP00000011687 --------------MTRFGHDVNNNFGTMNPHPAHNSSPIRSTL--NYVWSTTEILGQGATGFVFKGREK--KTGQEYAIKVF-----NS-LNYMARSL-----EARRREFEVL-RKVDH D_rerio_ENSDARP00000087779 ---------------------------------------------------------------------Q--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------KTGDLFAVKVF-----NS-ISFL-RPM-----DVQMREFEVL-KKLNH P_pygmaeus_ENSPPYP00000021585 --------------EQEKSATEFLVKARGDFLYRWGNPAQNTAS--SDQFERLRTLGTGSFGRVMLVRHR--ETGGHYAMKIL-----HK-QKLV-KLKQV---EHTLNEKRIL-QAIDF T_rubripes_ENSTRUP00000005140 ---------------------------------------------------------------------Q--KTGDLYAVKVF-----NN-LSFL-RPL-----DVQMREFEVL-KKLNH C_elegans_T25E12.4a IQSALMPVTPQSSVVGGKRIDKLKVPTEGETGHLGAKIQTEHEFSQLYQIFAEEVLGSGQFGTVYGGIHR--RNGQHVAVKLI-----DK-LKFPPNKE-----DLLRAEVQIL-EKVDH H_sapiens_ENSP00000366488 --------------EQEESVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLRTLGMGSFGRVMLVRHQ--ETGGHYAMKIL-----NK-QKVV-KMKQV---EHILNEKRIL-QAIDF P_troglodytes_ENSPTRP00000035898 --------------EQEESVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLRTLGMGSFGRVMLVRHR--ETGGHYAMKIL-----NK-QKVV-KMKQV---EHILNEKRIL-QAIDF A_carolinensis_ENSACAP00000002909 ----------------------------------------------MEQYHVLEMIGEGSFGRVYKGRRK--YTTKIVALKFI-----PK-VGRSQKEL-----KNLQREIEIM-RGLHH M_mulatta_ENSMMUP00000026815 --------------TEQETVNEFLAKARGDFLYRWGNPAQNTAS--SDQFERLKTLGTGSYGRVMLVRHR--ETGNHYAMKIL-----DK-QKVV-RLKQV---EHTLNEKRIL-QAINF A_carolinensis_ENSACAP00000008611 ----------------------------------------------MNRYTTIKQLGDGTYGSVILGRSN--ESGELIAIKRM-----KR-KFYS-WEE-----CMNLREVKSL-KKLSH O_latipes_ENSORLP00000008832 --------------MFLFAVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGSFGRVMLVKHK--ETGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF G_aculeatus_ENSGACP00000024909 --------------SEMESVKEFLAKAKEDFLKKWESPAQNTAG--LEQFERLKTLGTGSFGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF P_pygmaeus_ENSPPYP00000023332 ---------------------------------MLLLKKHTEDI--SSVYEIRERLGSGAFSEVVLAQER--GSAHLVALKCI-----PK-KALR-GKE-----ALVENEIAVL-RRISH D_melanogaster_FBpp0081883 -----------ATPTVAAGQDLGDGACSSKNTDSKFQSYVNGNG--NGVYKIIKTLGKGNFAKVKLAIHV--PTGREVAIKVI-----DK-TQLNTSAR-----QKLYREVKIM-KLLNH M_domestica_ENSMODP00000019211 ------------------------------LISSSSSRLRDPGALMMEKYHVLEMIGEGSFGRVYKGRKK--YSAQVVALKFI-----PK-LGRSDKEL-----RNLHREIEIM-RGLRH O_cuniculus_ENSOCUP00000002072 ---------------------------------MLLLKKQTADI--SSVYELREKLGSGAFSEVVLAQER--GSAHLVALKCI-----PK-NALR-GKE-----ALVENEIAVL-RRVNH D_rerio_ENSDARP00000013244 --------------LSLCTVKEFLAKAKEDFLKKWENPAQNTAS--LDHFERLKTLGTGSFGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF T_guttata_ENSTGUP00000006427 -------------------------------------IVSEGDP--KTKYTEFVHIGQGGFGTVYKAINP--ATGDVVALKKM-----PL-RKRS-RN------ELVVNEIQVM-KENRH O_latipes_ENSORLP00000018527 --------------SVRDKVKEFLAKAKEDFLKKWENPSQNTAN--LEQFERLKTLGTGSFGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF M_domestica_ENSMODP00000023457 ----------------------------------------------MHRYTTIKQLGDGTYGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH A_carolinensis_ENSACAP00000009974 -----------------------------------------ADV--EKCYKIGRTIGDGNFAVVMECHNC--NTNQNYAMKII-----DK-SKLK-GKE-----DMLDNEILII-KSLSH D_rerio_ENSDARP00000002825 --------------NEMESVKEFLAFAKEDFLRKWENPAQNTAC--LEDFDRLKTLGTGSFGRVMLVRHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF A_aegypti_AAEL004761-PA ----------------------------------------------MNRYLTLSQLGDGTYGTVVLGQRK--DTGEKVAIKRM-----KR-KYYS-WEE-----AMNLREVKSL-KKLSH M_mulatta_ENSMMUP00000018568 --------------SEQESVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGSFGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF T_rubripes_ENSTRUP00000013710 --------------SEMESVKEFLAKAKEDFLKKWENPAQNTAC--LEQFERLKTLGTGSFGRVMLVKHR--ETGQHYAMKIL-----NK-QKVV-KLKQI---EHTLNEKRIL-QAVSF P_troglodytes_ENSPTRP00000018062 --------------SNSSDVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGSFGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF H_sapiens_ENSP00000309591 --------------SEQESVKEFLAKAKEDFLKKWESPAQNTAH--LDQFERIKTLGTGSFGRVMLVKHK--ETGNHYAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF T_nigroviridis_ENSTNIP00000013350 --------------NEMESVKEFLAKAKEDFLKKWENPAQQTAA--LDHFDRLKTLGTGSFGRVMLVKHK--ETGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF T_rubripes_ENSTRUP00000032222 -----------VCFSSECLVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGSFGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF O_anatinus_ENSOANP00000000884 ----------------------QVPVCFRRISREEAKTFPHTKQ--VGAYLVGKMINKGSFAKVMEGLHL--LTGEKVAIKVI-----DK-RKAQ-EDGYIL--ENMRREPRIQ-QMIKH M_mulatta_ENSMMUP00000025345 ---------------------------MGANTSSKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKN--DTKKMYAMKYM-----NK-QKCVERNEV----RNVFKELQIM-QGLEH E_caballus_ENSECAP00000019558 ----------------------------------------------MNRYTTIKQLGDGTYGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH A_aegypti_AAEL007931-PA -----------SQQGGSGSTKAEQRLTHEQFRAALQMVVSAGDP--RENLENFTKIGEGSTGTVCIATDK--STGRQVAVKKM-----DL-RKQQ-RR------ELLFNEVVIM-RDYHH C_familiaris_ENSCAFP00000024262 ------------------SVKEFLAKAKEDFLKKWENPAQNTAH--LDQFERIKTLGTGSFGRVMLVKHK--ETGNHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVNF G_aculeatus_ENSGACP00000013822 --------------NEMESVKEFLAKAKEDFLKKWENPAQQTAA--LDHFERLKTLGTGSFGRVMLVKHK--ESGQHFAMKIL-----DK-QKVV-KLKQI---EHTLNEKRIL-QAVSF B_taurus_ENSBTAP00000020711 ----------------------------------------------MNRYTTIKQLGDGTYGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH C_familiaris_ENSCAFP00000003279 ----------------------------------------------MNRYTTIKQLGDGTYGSVLLGRSI--ESGELIAIKKM-----KR-KFYS-WEE-----CMNLREVKSL-KKLNH 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK M_mulatta_ENSMMUP00000010949 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK P_troglodytes_ENSPTRP00000034602 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK C_familiaris_ENSCAFP00000008270 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK M_musculus_ENSMUSP00000033939 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFENCCGLREGAVLTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK R_norvegicus_ENSRNOP00000025851 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRR--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK B_taurus_ENSBTAP00000049055 PNVVAAR----DVP-----EGMQSL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-NHIVNHPKMQESDNLSEVG-EFKLIHKIIDLGYAK P_pygmaeus_ENSPPYP00000020804 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK O_anatinus_ENSOANP00000001111 PNVVAAR----EVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--FLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-QQRLIHKIIDLGYAK E_caballus_ENSECAP00000003662 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK M_domestica_ENSMODP00000012792 PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREEAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK G_gallus_ENSGALP00000005924 PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLENCCGLREEAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK G_gorilla_ENSGGOP00000006628 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--YLNQFENCCGLREGAILTLLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK A_carolinensis_ENSACAP00000012680 PNVVAAR----DVP-----EGMQSL-ALN-DLPLLAMEYCQGGDLRR--HLNQLENCCGVRERAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EERLIHKIIDLGYAK O_cuniculus_ENSOCUP00000006175 PNVVAAR----DVP-----EGMQNL-APN-DLPLLAMEYCQGGDLRK--XXXXXXXXXXXXXXXXXXXXXXX--XSALRYLHEN-RII--HRDLKPENIVLQQG-EQRXXXXXXXXXXXX X_tropicalis_ENSXETP00000036619 PNVVSAR----EVP-----DGLQKL-APN-DLPLLAMEYCEGGDLRK--YLNQFENCCGLKEGPILTLLSDI--SSALRYLHEN-RII--HRDLKPENIVLQPG-PQRLIHKIIDLGYAK O_latipes_ENSORLP00000003067 VNVVAAR----DVP-----AGMQKLVTAN-DLPLLAMEYCQGGDLRK--YLNVLDNCCGMREGSVLILLRDI--SSALTYLHNK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK T_nigroviridis_ENSTNIP00000019003 VNVVAAR----EVP-----EGMQKLMAIN-DLPLLAMEYCQGGDLRK--YLNLLENCCGMREGSVLILLCDI--SSALSYLHKK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK G_aculeatus_ENSGACP00000005440 INVVAAR----EVP-----EGMQEMITTN-DLPLLAMEYCQGGDLRK--HLNLLENCCGMREGSVLILLRDI--SSALTYLHKK-RII--HRDLKPENIVLQHG-EKRLIHKIIDLGYAK T_rubripes_ENSTRUP00000041917 VNVVAAR----EVP-----EGMQKLMVTN-DLPLLAMEYCQGGDLRK--YLNLLENCCGMREGSVLILLCDI--SSALTYLHKK-RII--HRDLKPENIVLQQG-EKRLIHKIIDLGYAK G_gallus_ENSGALP00000005196 PNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIIHKIIDLGYAK T_rubripes_ENSTRUP00000022821 INVVTAR----DVP-----EEVTHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPENCCGLKESEVLSLINDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI-SGKLVHKIIDLGYAK R_norvegicus_ENSRNOP00000034134 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK P_troglodytes_ENSPTRP00000055512 ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK H_sapiens_ENSP00000359424 ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK M_mulatta_ENSMMUP00000024306 ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK D_rerio_ENSDARP00000013115 LNVVTAK----DVP-----EEMMHI-ALN-DLPLLAMEYCSKGDLRK--LLSKPENCCGLKESEVLSLLNDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI-NGKLVHKIIDLGYAK C_familiaris_ENSCAFP00000014093 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK B_taurus_ENSBTAP00000009985 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK M_musculus_ENSMUSP00000026217 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKTIHKIIDLGYAK M_domestica_ENSMODP00000013213 PSVVKAC----DVP-----EEMNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDV-GGKVIHKIIDLGYAK T_guttata_ENSTGUP00000004836 PNVVRAC----EVP-----EEMNFL--VN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIVHKIIDLGYAK O_latipes_ENSORLP00000016017 INVVTAQ----DVP-----EEMKRI-ALN-DLPLLAMEYCSRGDLRK--VLSKPENCCGLKESEVLSLLSDV--GSGIQYLHEN-KII--HRDLKPENIVLQ------LVHKIIDLGYAK G_aculeatus_ENSGACP00000005520 INVVSAQ----DVP-----EEMRHI-ALN-DLPLLAMEYCSRGDLRK--ILSKPENCCGLKESEVLSLLNDV--GSGIQYLHEN-KII--HRDLKPENIVLQDI-NGKLVHKIIDLGYAK P_pygmaeus_ENSPPYP00000002975 ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK X_tropicalis_ENSXETP00000038296 PNVVKAC----EVP-----PEMDFL--VN-DVPHLAMEYCAGGDLRK--LLNKPENCCGLKESQVLNLMSDI--GSGIQYLHEK-RII--HRDLKPENIVLQEC-NGKTVHKIIDLGYAK T_nigroviridis_ENSTNIP00000014802 INVVTAR----DVP-----EEMKHI-SLN-DLPLLAMEYCSRGDLRK--MLSKPENCCGLKESEVLSLLNDV--GSGIQYLHKN-KII--HRDLKPENIVLQDI-SGKLVHKIIDLGYAK A_carolinensis_ENSACAP00000011973 PNIVKAC----DVP-----EEMNFL--VN-DVPLLAMEYCSKGDLRK--LLNLPENCCGLKESQILNLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQDE-GGKIIHKIIDLGYAK E_caballus_ENSECAP00000005937 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIMHKIIDLGYAK G_aculeatus_ENSGACP00000008884 GNVVQAR----EIP-----EELHSI-ALN-DLPLLAMEYCSRGDLRK--VLNKPENCCGLKESEVLSLLSDIDAGSGIQYLHEN-KII--HRDLKPENIVLQEI-GGKLIHKIIDLGYAK T_rubripes_ENSTRUP00000036336 GNVVQAR----EVP-----EELTSI-SLN-DLPLLAMEYCSRGDLRK--LLNKPENCCGLKESEVFSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEV-DGKLVHKLIDLGYAK O_anatinus_ENSOANP00000003934 DSLVKACIRTSNIS-----EEQFSI--VSFKHPQLSREYCSGGLIERLILLNKTENCCGLKESQILSLLSDI--GSGIQYLHEN-RII--HRDLKPENIVLQNV-DGKVIHKIIDLGYAK O_latipes_ENSORLP00000011761 LNVVQAR----EVP-----EELHAI-ALN-DLPLLAMEYCSRGDLRK--VLHKPENCCGLKESEVLSLLKDI--GSGIQYLHEN-KII--HRDLKPENIVLQEI-DGKLVHKIIDLGYAK T_nigroviridis_ENSTNIP00000019642 TNVVQAR----EVP-----EELTSI-SIN-DLPLLAMEYCSRGDLRK--ILNKPENCCGLKESEVLSLLSDI--GSGVQYLHDN-KII--HRDIKPENIVLQEN-DGKLVHKLIDLGYAK T_guttata_ENSTGUP00000005662 PNVVAAR----DVP-----EGMQKL-APN-DLPLLAMEYCQGGDLRK--YLNQLENCCGLREEAILILLSDI--ASALRYLHEN-RII--HRDLKPENIVLQQG-EQRLIHKIIDLGYAK G_gorilla_ENSGGOP00000008804 ANVVKAC----DVP-----EELNIL--IH-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKIIHKIIDLGYAK T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 ANVVKAC----DVP-----EELNFL--IN-DVPLLAMEYCSGGDLRK--LLNKPENCCGLKESQILSLLSDI--GSGIRYLHEN-KII--HRDLKPENIVLQDV-GGKXXXXXXXXXXXX A_aegypti_AAEL003245-PA ENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVSSCSGLKELEVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM-GDRMVYKLTDLGYAK A_gambiae_AGAP009166-PA DHIVRTV----DVQPRAFIEELLRS-SAN-GLPVLCMEYCEGGDLRR--VLNRVENCSGLREQDVRDVLRSL--RSAIAYLHSL-KIT--HRDIKPENLVLKQH-GDRFIYKLTDLGYAK A_aegypti_AAEL010548-PA ENIVRTV----RVQPETFLQELIKH-STN-KLPILCMEYCEGGDLRR--VLNRVSSCSGLKELEVREILRSL--RNAISYLHNL-RIT--HRDIKPENIVLKQM-GDRMVYKLTDLGYAK D_melanogaster_FBpp0082690 PHIVAGV----DIEDPDFLEYLNGMFSA--KLPVIVLEYCNGGDVRK--RLQSPENANGLTEFEVRQILGAL--RKALHFLHSQCGIC--HRDLKPDNIVIQRGVDGKKIYKLTDFGLAR T_rubripes_ENSTRUP00000005087 SNIVRLY----AVE-----ELPS-------KQKILVMEYCSGGSLLT--VLEEPENAFGLPETEFLTVLQCV--VRGMNHLREN-GVV--HRDIKPGNIMRQAGEDGKSVYKLTDFGAAR D_rerio_ENSDARP00000014302 VNIVKLF----AVE-----EIISNP-----KQKILVMEYCSGGSLLN--MLEQPEHAFGLPESEFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVGEDGRSVYKLADFGAAR D_rerio_ENSDARP00000074566 VNIVKLF----AVE-----EIISNP-----KQKILVMEYCSGGSLLN--MLEQPEHAFGLPESEFLIVLHCV--AHGMNHLREN-SVV--HRDIKPGNIMRQVGEDGRSVYKLADFGAAR T_nigroviridis_ENSTNIP00000010090 SNIVRLY----AVE-----ELPS-------KQKVLVMEYCSGGSLLM--LLEEPENAFGLPETEFLTVLQCV--VRGMNHLREN-GVV--HRDIKPGNIMRQTGEDGKSVYKLTDFGAAR B_taurus_ENSBTAP00000046540 QNIIKLF----AVE-----ETGAG------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--AAGMNHLREN-GIV--HRDIKPGNIMRLLGEEGQSIYKLTDFGAAR P_pygmaeus_ENSPPYP00000000308 QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR E_caballus_ENSECAP00000000587 QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLGEEGQSIYKLTDFGAAR H_sapiens_ENSP00000356087 QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR X_tropicalis_ENSXETP00000015947 KNIVKLF----AIE-----EEMSS------RHKVLVMEFCPCASLYS--VLEEPANAYGLPESEFLIVSRDV--VAGMNHLREN-GII--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR A_carolinensis_ENSACAP00000012863 QNIVKLF----SVE-----EIEIS------KQKVLVMEYCSGGSLLS--LLEEPENAFGLSESEFLIVLHCV--VSGMNHLREN-GIV--HRDIKPGNIMRLTSEDRQSIYKLSDFGAAR M_mulatta_ENSMMUP00000038190 QNIIKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLTDFGAAR G_aculeatus_ENSGACP00000000783 KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGLPEDEFLLVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR C_familiaris_ENSCAFP00000035372 QNIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLESPENAFGLPEDEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLMGEEGQSIYKLTDFGAAR M_domestica_ENSMODP00000002458 ENIVKLF----AVE-----ETGSN------KQKVLVMEYCSSGSLLS--VLESPENAFGLSEAEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLLGEDGQSIYKLTDFGAAR T_nigroviridis_ENSTNIP00000005945 KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGLPEDEFLIVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR M_musculus_ENSMUSP00000054126 QNIVKLF----AVE-----ETGGS------RQKVLIMEYCSSGSLLS--VLEDPENTFGLSEEEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGEEGQSIYKLSDFGAAR T_guttata_ENSTGUP00000006693 KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAFGLPESEFLIVLRDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR A_carolinensis_ENSACAP00000003243 KNIVKLF----AIE-----EETTS------RHKVLVMEFCPCGSLYT--VLEEPSNAYGLPETEFLIVLKDV--VAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR R_norvegicus_ENSRNOP00000030127 ENIVKLF----AVE-----ETGGS------RQKVLVMEYCSSGSLLS--VLEDPENTFGLPEEEFLVVLRCV--VAGMNHLREN-GIV--HRDIKPGNIMRLVGKEGQSIYKLSDFGAAR O_cuniculus_ENSOCUP00000010441 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR E_caballus_ENSECAP00000018587 KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR M_mulatta_ENSMMUP00000010063 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR P_troglodytes_ENSPTRP00000008798 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR P_pygmaeus_ENSPPYP00000005386 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR H_sapiens_ENSP00000329967 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR C_familiaris_ENSCAFP00000000505 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR O_anatinus_ENSOANP00000008566 QNIIKLF----AVE-----ETGNS------KQKVLVMEYCARGSLLT--VLEEPENAFGLPEEEFLVVLQCV--VAGINHLREN-GIV--HRDIKPGNIMRLVGEAGQSIYKLTDFGAAR G_gallus_ENSGALP00000015982 KNIVKLF----AIE-----EETTT------RHKVLVMEFCPCGSLYT--VLEEPSNAFGLPESEFLIVLRDVVKVAGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR M_musculus_ENSMUSP00000020316 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR G_aculeatus_ENSGACP00000000485 SNIVRLY----AVE-----ELPS-------KQNVLVMEYCSGGSLLS--LLEESENAFGLPETEFLIVLQCV--VQGMNHLREN-GVV--HRDIKPGNIMRQVGEDGKSVYKLTDFGAAR D_melanogaster_FBpp0080920 ENIVKLL----AIE-----EDQEG------RGKVIVMELCTGGSLFN--ILDDPENSYGLPEHEFLLVLEHL--CAGMKHLRDN-KLV--HRDLKPGNIMKFISEDGQTIYKLTDFGAAR O_latipes_ENSORLP00000019746 SNIVRLL----AVE-----ELPS-------RHKVLVMEFCSGGSLLN--LLEEPENAFGLPETEFLTVLQCI--VQGMNHLREN-GVV--HRDIKPGNILRQVGEDGKSIYKLTDFGAAR G_gallus_ENSGALP00000021757 KNIVKLF----AVE-----ETGSS------KQKVLVMEYCSSGSLLS--ILEDPANAFGLAEPEFLVVLQCV--VAGMNHLREN-GVV--HRDIKPGNIMRLVGEDGQSIYKLTDFGAAR A_aegypti_AAEL005359-PA DNIVKLL----DIE-----DDQEG------RGKVIVMELCTGGSLFN--ILDDPENTYGLPQREFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYISEDGKTIYKLTDFGAAR B_taurus_ENSBTAP00000023134 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV-EVGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR T_guttata_ENSTGUP00000001142 KNIVKLF----AVE-----ETGSS------KQKVLVMEYCSSGSLLN--VLEDPANAFGLAESEFLIVLQCV--VAGMNHLREN-GVV--HRDIKPGNIMRLVGEDGQSIYKLTDFGAAR A_gambiae_AGAP009565-PA NNIVKLL----DIE-----DDQEG------RGKVIVMELCTGGSLFN--ILDDPENTYGLPQKEFLLVLEHL--SAGMKHLRDN-NLV--HRDLKPGNIMKYISEDGQTVYKLTDFGAAR R_norvegicus_ENSRNOP00000009260 KNIVKLF----AIE-----EETTT------RHKVLIMEFCPCGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR C_intestinalis_ENSCINP00000011687 KNVVRLF----SVE-----EELTT------KHDVIIMELCPNGSLYS--MLDDPENLYGLPESEFHRVLSHI--TAGMKHLHDK-GIV--HRDLKPGNIMRSLDDDGTAVYKLTDFGAAR D_rerio_ENSDARP00000087779 KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEEPTNAYGLPEDEFLIVLQDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGDDGFSVYKLTDFGAAR O_anatinus_ENSOANP00000015719 KNIVKLF----AIE-----EETTT------RHKVLVMEFCPYGSLYT--VLEEPSNAYGLPESEFLIVLRDV--VGGMNHLREN-GIV--HRDIKPGNIMRVIGEDGQSVYKLTDFGAAR P_pygmaeus_ENSPPYP00000021585 PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--HLRRVGSF---SEPHACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLRVTDFGFAK T_rubripes_ENSTRUP00000005140 KNIVKLF----AVE-----EESNT------RHKVLVMEYCPCGSLYT--VLEESSNAYGLPEDEFLIVLHDV--VAGMNHLREY-GIV--HRDIKPGNIMRVIGEDGRSVYKLTDFGAAR C_elegans_T25E12.4a PGVVHFM----QML-----ETT--------DRIFVVMEKLKGDMLEM--ILSSEKGR--LSERTTQFLVAQI--LEALRYLHHL-NIV--HCDLKPENILLNSNS-DFPQVKLCDFGFAR H_sapiens_ENSP00000366488 PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--RLQRVGRF---SEPHACFYAAQV--VLAVQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK P_troglodytes_ENSPTRP00000035898 PFLVKLQ----FSF-----KDN--------SYLYLVMEYVPGGEMFS--RLQRVGRF---SEPHACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK A_carolinensis_ENSACAP00000002909 PNIVQML----DSF-----ETD--------KEVVVVTDYAE-GELFQ--ILEDDGN---LPEEQVQIIASQL--VSALYYLHSH-RIL--HRDMKPQNILLG----KGGVIKLCDFGFAR M_mulatta_ENSMMUP00000026815 PFLVKLQ----FSF-----KDN--------SNLYLVMEYVPGGEMFS--HLRRVGRF---SEPQACFYAAQV--VLAFQYLHSL-DLI--HRDLKPENLLID----QQGYLQVTDFGFAK A_carolinensis_ENSACAP00000008611 ANVVKLK----EVI-----REN--------DNLYFVFEYMKE-NLYQ--LMKERNKL--FPESTVRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR O_latipes_ENSORLP00000008832 PFLVQLE----HSF-----KDT--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK G_aculeatus_ENSGACP00000024909 PFLVRLE----YSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRFSVHSEPHARFYAAQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK P_pygmaeus_ENSPPYP00000023332 PNIVALE----DVH-----ESP--------SHLYLAMELVTGGELFD--RIMERGS---YTEKDASHLVGQV--LGAVSYLHSL-GIV--HRDLKPENLLYATPF-EDSKIMVSDFGLSK D_melanogaster_FBpp0081883 PNIVRLF----QVI-----ESE--------RTLYLVMEYASRGELFD--HLVKNGRM---RERDARVIFRQL--VSAIQYCHSK-FVV--HRDLKAENLLLD----QHMNIKIADFGFGN M_domestica_ENSMODP00000019211 PNIIQML----DSF-----ETD--------KEVVVVTDYAE-GELFQ--ILEDDGK---LPEDQVQAIAAQL--VSALYYLHSH-RIL--HRDMKPQNILLA----KGGGIKLCDFGFAR O_cuniculus_ENSOCUP00000002072 PNIVALE----DVH-----ESP--------SHLYLAMELVTGGELFD--RIMERGS---YTEKDASHLVAQV--LGAVSYLHSL-GIV--HRDLKPENLLYATPF-EDSKIMVSDFGLSK D_rerio_ENSDARP00000013244 PFLVRLE----HSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK T_guttata_ENSTGUP00000006427 PNIVNYI----DSY-----LVN--------EDLWLVMEYVDGGTLTS--VLVQVF----MEERIIAAISREC--LKALDFLHSK-NVI--HRDVKSDNILLG----MDGSVKLTDFGLCA O_latipes_ENSORLP00000018527 PFLVRLE----FSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRKIGRF---SEPHARFYATQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK M_domestica_ENSMODP00000023457 ANVVKLK----EVI-----REN--------DHLYFVFEYMKE-NLYQ--LMKERNKL--FPESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR A_carolinensis_ENSACAP00000009974 PNIVSLI----EVF-----ETD--------AEIYLVLEYIPGGDLFD--AIIESVK---FTECDAALMITDL--CEALVYIHSK-NIV--HRDLKPENLLVQRNPDKTTTLKLADFGLAK D_rerio_ENSDARP00000002825 PFLVRLE----YSF-----KDN--------TNLYMVMQYVQGGEMFS--HLRRIGRF---SEPHARFYASQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK A_aegypti_AAEL004761-PA ANVVKLK----EVI-----REN--------DVLYFVFEYMQE-NLYQ--LIKDRENH--FPEATIRLILQQI--LTGLAFMHRH-GFF--HRDLKPENVLCC----GPELVKIADFGLAR M_mulatta_ENSMMUP00000018568 PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK T_rubripes_ENSTRUP00000013710 PFLVRLE----YSF-----KDN--------TNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHAL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK P_troglodytes_ENSPTRP00000018062 PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK H_sapiens_ENSP00000309591 PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK T_nigroviridis_ENSTNIP00000013350 PFLVCLE----HSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK T_rubripes_ENSTRUP00000032222 PFLVCLE----HSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK O_anatinus_ENSOANP00000000884 PNIVQLY----ETL-----ETE--------NSYYMVMELCLGGDLLD--RIYNKQK---LEEEEVKKFTRQI--VSAVEHLHRH-GIV--HRDLKIENFLLD----ENSNIKIIDFGLSN M_mulatta_ENSMMUP00000025345 PFLVNLW----YSF-----QDE--------EDMFMVVDLLLGGDLRY--HLQQNVR---FKEETVKLFICEL--VMALDYLQSQ-RII--HRDMKPDNILLD----EHGHVHITDFNIAA E_caballus_ENSECAP00000019558 ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--FPESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR A_aegypti_AAEL007931-PA PNIVETY----SSF-----LVN--------DELWVVMEYLEGGALTD--IVTHSR----MDEEQIATVCKQC--LKALSYLHSQ-GVI--HRDIKSDSILLA----SDGRVKLSDFGFCA C_familiaris_ENSCAFP00000024262 PFLVKLE----FSF-----KDN--------SNLYMVMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK G_aculeatus_ENSGACP00000013822 PFLVRLE----HSF-----KDN--------SNLYMIMEYVPGGEMFS--HLRRIGRF---SEPHARFYAAQI--VLTFEYLHSL-DLI--YRDLKPENLLID----QQGYIQVTDFGFAK B_taurus_ENSBTAP00000020711 ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--FPESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR C_familiaris_ENSCAFP00000003279 ANVVKLK----EVI-----REN--------DHLYFIFEYMKE-NLYQ--LIKERNKL--FPESAIRNIMYQI--LQGLAFIHKH-GFF--HRDLKPENLLCM----GPELVKIADFGLAR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS M_mulatta_ENSMMUP00000010949 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS P_troglodytes_ENSPTRP00000034602 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS C_familiaris_ENSCAFP00000008270 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS M_musculus_ENSMUSP00000033939 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS R_norvegicus_ENSRNOP00000025851 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS B_taurus_ENSBTAP00000049055 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS P_pygmaeus_ENSPPYP00000020804 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS O_anatinus_ENSOANP00000001111 ELDQS----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---TVR----QKS E_caballus_ENSECAP00000003662 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS M_domestica_ENSMODP00000012792 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS G_gallus_ENSGALP00000005924 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS G_gorilla_ENSGGOP00000006628 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS A_carolinensis_ENSACAP00000012680 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS O_cuniculus_ENSOCUP00000006175 XXXXX----XXXX-XXXXXXXXX-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHS---KVR----QKS X_tropicalis_ENSXETP00000036619 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QKK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHG---KVR----EKS O_latipes_ENSORLP00000003067 ELDQS----SLCT-SFVGTLQYL-----------------------APELIE--------RMQ---Y-TVTVDYWSFGTLVFECITGFRPFLPTWQ--P---VPWHN---KVR----LKE T_nigroviridis_ENSTNIP00000019003 QLDHS----SLCV-SFVGTLQYL-----------------------APELIE--------RQK---Y-TVTVDYWSFGTLVFECITGFRPFLPSWQ--P---VPWHH---KVR----LKG G_aculeatus_ENSGACP00000005440 ELDQS----SLCT-SFVGTLQYL-----------------------APELIE--------REK---Y-TVTVDYWSFGTLVFECITGFRPFLPTWQ--P---IPWHN---KLR----TKQ T_rubripes_ENSTRUP00000041917 QLDQS----SLCT-SFVGTLQYL-----------------------APELIE--------RQM---Y-TVTVDYWSFGTLVFECITGFRPFLPSWQ--P---VPWHN---KVM----LKG G_gallus_ENSGALP00000005196 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKS---Y-SVTVDYWSFGTMVFECIAGFRPFLHNLQ--P---FTWHE---KIK----KKD T_rubripes_ENSTRUP00000022821 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TVTVDYWSFGTMLFECSCGFRPFLHNLQ--P---VQWAS---KVR----NKG R_norvegicus_ENSRNOP00000034134 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD P_troglodytes_ENSPTRP00000055512 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD H_sapiens_ENSP00000359424 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD M_mulatta_ENSMMUP00000024306 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD D_rerio_ENSDARP00000013115 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------GKS---Y-TVTVDFWSFGTMIFECCCGFRPFLHNLQ--P---VQWTS---KVR----NKG C_familiaris_ENSCAFP00000014093 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD B_taurus_ENSBTAP00000009985 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD M_musculus_ENSMUSP00000026217 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD M_domestica_ENSMODP00000013213 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIVGYRPFLHHLQ--P---FTWHE---KIK----KKD T_guttata_ENSTGUP00000004836 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKS---Y-SVTVDYWSFGTMVFECIAGFRPFLHNLQ--P---FAWHE---KIK----KKD O_latipes_ENSORLP00000016017 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TVTVDYWSFGTMIFECSCGFRPFLHNLQ--P---VQWAS---KVK----NKG G_aculeatus_ENSGACP00000005520 DLDQD----SLCT-SFVGTLQYL-----------------------APELFE--------NHP---Y-TVTVDYWSFGTMMFECICGFRPFLHNLQ--P---VQWAT---KVK----NKG P_pygmaeus_ENSPPYP00000002975 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD X_tropicalis_ENSXETP00000038296 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-SVTVDYWSFGTMVFECIAGFRPFLHNMQ--P---FTWHE---KIK----KKD T_nigroviridis_ENSTNIP00000014802 DLDQG----SLCT-SFVGTVQYL-----------------------APELFE--------NKP---Y-TVTVDYWSFGTMLFECSCGFRPFLHNLQTSA---VLRAS---KVR----NKG A_carolinensis_ENSACAP00000011973 DLDQG----SLCT-SFVGTLQYL-----------------------APELFD--------NKP---Y-TASVDFWSFGTVVFECITGFRPFLHNQQ--P---FTWHD---KIK----KKD E_caballus_ENSECAP00000005937 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD G_aculeatus_ENSGACP00000008884 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------SKP---Y-TVTVDYWSFGTVIFECTCGFRPFLHHMQ--P---VQWTS---KVK----NKG T_rubripes_ENSTRUP00000036336 DLDQG----SLCT-SFVGTIQYL-----------------------APELFE--------NKP---Y-TVTVDYWSFGTVIFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG O_anatinus_ENSOANP00000003934 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFEGIVGYRPFLHHLQ--P---FMWHE---KIK----KKD O_latipes_ENSORLP00000011761 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------SKP---Y-TVSVDYWSLGTVLFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG T_nigroviridis_ENSTNIP00000019642 DLDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TVTVDYWSFGTVIFECICGFRPFLHHMQ--P---VQWTS---KVK----NKG T_guttata_ENSTGUP00000005662 ELDQG----SLCT-SFVGTLQYL-----------------------APELLE--------QQK---Y-TVTVDYWSFGTLAFECITGFRPFLPNWQ--P---VQWHT---KVR----QKS G_gorilla_ENSGGOP00000008804 DVDQG----SLCT-SFVGTLQYL-----------------------APELFE--------NKP---Y-TATVDYWSFGTMVFECIAGYRPFLHHLQ--P---FTWHE---KIK----KKD T_guttata_ENSTGUP00000016868 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000011297 XXXXX----XXXX-XXXXXXXXX-----------------------XXXXXX--------XXX---X-XXXXXXXXXXXXXXXXXXXXXXXXXXXX--X---XXXHE---KIK----KKD A_aegypti_AAEL003245-PA ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY--------CDR---Y-NCSVDYWSMGIIAFEIICGIRPFSPHSI--V---AKWMM---LVQ----QKK A_gambiae_AGAP009166-PA ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY--------CDR---Y-NCSVDYWSMGVIGFEIVTGVRPFIPHAP--I---TRWMM---HVQ----QKK A_aegypti_AAEL010548-PA ALDKQ----SLNA-SLVGTVEYI-----------------------APDLIY--------CDR---Y-NCSVDYWSMGIIAFEIICGIRPFSPHSI--V---AKWMM---LVQ----QKK D_melanogaster_FBpp0082690 GTPDQ----TMVQ-SVVGTRHYY-----------------------APEVVE--------NGF---Y-NSTVDLWSFGVIAYELVTGELPFIPHQT-----LKNIIL---NLI----KKP T_rubripes_ENSTRUP00000005087 ELEDD----EKFI-SIYGTEEYL-----------------------HPDMYERAVLRKPHQKS---Y-GVSVDLWSIGVTFYHAATGSLPFIPYGG--PRKNKLTMF---KIT----TEK D_rerio_ENSDARP00000014302 ELEDD----EKFV-SIYGTEEYL-----------------------HPHMYERAVLRIPQQKA---Y-GVSVDLWSIGVTIYHMATGSLPFRPFGG--PRKNKQMMH---KIT----TEK D_rerio_ENSDARP00000074566 ELEDD----EKFV-SIYGTEEYL-----------------------HPHMYERAVLRSPQQKA---Y-GVSVDLWSIGVTIYHMATGSLPFRPFGG--PRKNKQMMH---KIT----TEK T_nigroviridis_ENSTNIP00000010090 ELEDD----EKFI-SIYGTEEYL-----------------------HPDMYKCAVLRKPHQKS---Y-GVSVDLWSIGVTFYHAATGSLPFVPFGG--PRKNKLTMF---KIT----TEK B_taurus_ENSBTAP00000046540 ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMY---RIT----TEK P_pygmaeus_ENSPPYP00000000308 ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMH---RIT----TEK E_caballus_ENSECAP00000000587 ELDDD----EKFI-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVAVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMY---RIT----TEK H_sapiens_ENSP00000356087 ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK X_tropicalis_ENSXETP00000015947 ELDDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----AGK A_carolinensis_ENSACAP00000012863 ELDDD----EKFE-SVYGTEEYL-----------------------HPDIYKRAVLKKPQQKA---Y-GVTVDLWSIGVTFYHAATGSLPFIPFGG--PRRNKEIMY---KIT----TEK M_mulatta_ENSMMUP00000038190 ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK G_aculeatus_ENSGACP00000000783 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK C_familiaris_ENSCAFP00000035372 ELDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKT---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEMMY---RIT----TEK M_domestica_ENSMODP00000002458 ELEDD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFVPFGG--PRRNKEIMYARDQGG----KER T_nigroviridis_ENSTNIP00000005945 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK M_musculus_ENSMUSP00000054126 KLDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK T_guttata_ENSTGUP00000006693 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK A_carolinensis_ENSACAP00000003243 ELDDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK R_norvegicus_ENSRNOP00000030127 KLDDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---F-GVTVDLWSIGVTLYHAATGSLPFIPFGG--PRRNKEIMY---RIT----TEK O_cuniculus_ENSOCUP00000010441 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK E_caballus_ENSECAP00000018587 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KIL----TGK M_mulatta_ENSMMUP00000010063 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK P_troglodytes_ENSPTRP00000008798 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK P_pygmaeus_ENSPPYP00000005386 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK H_sapiens_ENSP00000329967 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK C_familiaris_ENSCAFP00000000505 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK O_anatinus_ENSOANP00000008566 ELADD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLKKPQQKA---F-GVTVDLWSIGVTFYHAATGSLPFVPFGG--PRRNKEIMF---RMT----SEK G_gallus_ENSGALP00000015982 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKEHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK M_musculus_ENSMUSP00000020316 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSVGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK G_aculeatus_ENSGACP00000000485 VLEDD----EKFM-SIYGTEEYL-----------------------HPDMYERAVLRKPHQKS---Y-GVSVDLWSIGVTFYHAATGSLPFAPFGG--PRKNKPTMY---KIT----TEK D_melanogaster_FBpp0080920 ELEDN----QPFA-SLYGTEEYL-----------------------HPDLYERAVLRKSIQRS---F-TANVDLWSIGVTLYHVATGNLPFRPFGG---RKNRETMH---QIT----TKK O_latipes_ENSORLP00000019746 ELEDD----EKFV-SIYGTEEYL-----------------------HPDMYERAVLRKHHQKT---Y-GVSVDLWSIGVTLYHSATGSLPFTPFEG--PRKNKPVMH---KIT----REK G_gallus_ENSGALP00000021757 ELEDD----EKFV-SVYGTEEYL-----------------------HPDMYERAVLRKPQQKA---Y-GVTVDLWSIGVTFYHAATGRLPFVPFGG--PRRNKETMY---KIT----TEK A_aegypti_AAEL005359-PA ELEEN----QQFV-SLYGTEEYL-----------------------HPDMYERAVLRKSINRS---F-TANVDLWSIGVTLYHVATGNLPFRPFGG---RKNKETMH---HIT----TKK B_taurus_ENSBTAP00000023134 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK T_guttata_ENSTGUP00000001142 ELEDD----EKFV-SVYGTEEYL-----------------------HPDVYERAVLRKPQQKA---F-GVTVDLWSIGVTFYHAATGSLPFVPFGG--PRRNKEIMY---KIT----TEK A_gambiae_AGAP009565-PA ELGEN----QQFA-SLYGTEEYL-----------------------HPDMYERAVLRKSINRS---F-TANVDLWSIGVTLYHVATGNLPFRPYGG---RKNKETMY---HIT----TKK R_norvegicus_ENSRNOP00000009260 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSVGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TGK C_intestinalis_ENSCINP00000011687 ELGDD----EQFM-SLYGTEEYL-----------------------HPDIYERAVLRKHAGKM---F-SATVDLWSLGVTLYHVATGMLPFRPYGG--ARRNKDVMY---RIT----TEK D_rerio_ENSDARP00000087779 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK O_anatinus_ENSOANP00000015719 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGALPFRPFEG--PRRNKEVMY---KII----TGK P_pygmaeus_ENSPPYP00000021585 RVKGR----TW---TLCGTPQYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMTVGFPPFY------ADEPIQIYE---KIV----SGR T_rubripes_ENSTRUP00000005140 ELEDD----EQFV-SLYGTEEYL-----------------------HPDMYERAVLRKDHQKK---Y-GATVDLWSIGVTFYHAATGSLPFRPFEG--PRRNKEVMY---KII----TEK C_elegans_T25E12.4a IIGEK----SFRR-SVVGTPAYL-----------------------APEVLR--------NKG---F-NRSLDMWSVGVIVYVSLSGTFPFN--------EDEDIND---QIQ----NAE H_sapiens_ENSP00000366488 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAVGFPPFY------ADQPIQIYE---KIV----SGR P_troglodytes_ENSPTRP00000035898 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAVGFSPFY------ADQPIQIYE---KIV----SGR A_carolinensis_ENSACAP00000002909 AMSIH----TMVLTSIKGTPLYM-----------------------SPELVE--------EKP---Y-DHTADLWSVGCILYELYVGTPPFY------TNSIFQLVS---LII----KDP M_mulatta_ENSMMUP00000026815 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMTAGFPPFY------ADQPIQIYE---KIV----SGK A_carolinensis_ENSACAP00000008611 EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR-------STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK O_latipes_ENSORLP00000008832 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK G_aculeatus_ENSGACP00000024909 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK P_pygmaeus_ENSPPYP00000023332 IQAGN-----MLG-TACGTPGYAEPVTLSGMAACVPVRASVCLWPPAPELLE--------QKP---Y-GKAVDVWALGVISYILLCGYPPFY------DESDPELFS---QIL----RAS D_melanogaster_FBpp0081883 TFDPN----AQLE-TFCGSPPYA-----------------------APELFM--------GRK---YAGPEVDAWSLGVVLYTLVSGSLPFD------GGTLKELRE---RVL----RGK M_domestica_ENSMODP00000019211 AMSTN----TMVLTSIKGTPLYM-----------------------SPELVE--------ERP---Y-DHTADLWSVGCILYELAVGTPPFY------TTSIFQLVS---LIL----KDP O_cuniculus_ENSOCUP00000002072 IQAGN-----MLG-TACGTPGYAESATRSTHA-----RACVRLWPPAPELLE--------QKP---Y-GKAVDVWALGVISYILLCGYPPFY------DESDPELFS---QIL----RAS D_rerio_ENSDARP00000013244 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK T_guttata_ENSTGUP00000006427 QLTQE---RSTRC-TVLGTPYWV-----------------------APEILK--------RKE---Y-NTQVDVWALGIVAIEMLEGEPPYF------KESPIQAQR---LIA----RNR O_latipes_ENSORLP00000018527 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK M_domestica_ENSMODP00000023457 EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR-------STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK A_carolinensis_ENSACAP00000009974 KVTKP------IF-TVCGTPTYV-----------------------APEILA--------ENG---Y-GLEVDMWATGVILYILLCGFPPFRSH----ERDQEELFQ---IIQ----LGH D_rerio_ENSDARP00000002825 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLMYEMAAGYPPFF------ADQPIQIYE---KIV----SGK A_aegypti_AAEL004761-PA EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLH-------STR---Y-GSAIDLWAVGCIMAELYT-FRPLFP-----GSSEVDQLF---KICSVLGTPD M_mulatta_ENSMMUP00000018568 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK T_rubripes_ENSTRUP00000013710 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLVYEMAAGYPPFF------ADQPIQIYE---KIV----SGK P_troglodytes_ENSPTRP00000018062 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK H_sapiens_ENSP00000309591 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK T_nigroviridis_ENSTNIP00000013350 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK T_rubripes_ENSTRUP00000032222 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK O_anatinus_ENSOANP00000000884 ILKLEGLSQELLN-TQCGSPAYA-----------------------APELLA--------HKK---Y-GPKVDVWSIGVSMFAMLTGTLPFTVD----PFNIKQLHQ---KMI----NGE M_mulatta_ENSMMUP00000025345 MLPRE----TQIT-TMAGTKPYM-----------------------APEMFS--------SRKGAGY-SFAVDWWSLGVTAYELLRGRRPYHIRS---STSSKEIVR---MFE----TTV E_caballus_ENSECAP00000019558 EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR-------STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK A_aegypti_AAEL007931-PA QVSQE---LPKRK-SLVGTPYWM-----------------------SPEVIS--------RLP---Y-GPEVDIWSLGIMVIEMIDGEPPFF------NEPPLQAMR---RIR----DMP C_familiaris_ENSCAFP00000024262 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK G_aculeatus_ENSGACP00000013822 RVKGR----TW---TLCGTPEYL-----------------------APEIIL--------SKG---Y-NKAVDWWALGVLIYEMAAGYPPFF------ADQPIQIYE---KIV----SGK B_taurus_ENSBTAP00000020711 EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR-------STS---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQVLGTPK C_familiaris_ENSCAFP00000003279 EIRSR----PPYT-DYVSTRWYR-----------------------APEVLLR-------STN---Y-SSPIDIWAVGCIMAEVYT-LRPLFP-----GASEIDTIF---KICQLLGTPK 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI M_mulatta_ENSMMUP00000010949 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPKYGPN----GCFKALDDILNLKLV--------HILNMVTGTI P_troglodytes_ENSPTRP00000034602 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI C_familiaris_ENSCAFP00000008270 EMDIV--VSEDLNGAVKFSSSLPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----GCFKALDDILNLKLV--------HILNMVTGII M_musculus_ENSMUSP00000033939 EVDIV--VSEDLNGAVKFSSSLPFPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPQYGPN----GCFRALDDILNLKLV--------HVLNMVTGTV R_norvegicus_ENSRNOP00000025851 EVDIV--VSEDLNGTVKFSSSLPFPNNL----NSVLAERLEKWLQLMLTWQPRQRG-------------------VDPQYGPN----GCFRALDDILNLKLV--------HILNMVTGTI B_taurus_ENSBTAP00000049055 EMDIV--VSEDLNGAVKFSSSLPHPNNL----NSVLAQRLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----GCFKALDDILNLKLL--------HVLNMVTGTL P_pygmaeus_ENSPPYP00000020804 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI O_anatinus_ENSOANP00000001111 ELDIV--VSEDLTGEVKFSSRLPYPNNL----NRVLALRLEKWLQLMLMWQPRQRG-------------------TDHIYGPN----GCFKALDDILNLKLI--------HVLNMVTGTM E_caballus_ENSECAP00000003662 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSRMGSRLCVGLECM---NCGTRA-------------------AFPKLGPC----FLWLGINIWVVLQLV--------HILNMVTGTI M_domestica_ENSMODP00000012792 ELDIV--VSEDLSGGVKFSSCLPYPNNL----NSILAQRLEKWLQLMLMWQARQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTV G_gallus_ENSGALP00000005924 ELDIV--VSEDLSGEVKFSSSLPCPNNL----NSVLAGKLEKWLQLMLMWHPRQRG-------------------TDPVYGPN----GCFKALDDILNLKLL--------HVLNMVTGTV G_gorilla_ENSGGOP00000006628 EVDIV--VSEDLNGTVKFSSSLPYPNNL----NSVLAERLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTI A_carolinensis_ENSACAP00000012680 ELDIV--VYEDLNGEVKFSSKLPHPNNL----NSVLADRLEKWLQLMLKWHPRQRG-------------------TDPTYGTN----GCFKALDDILNLKLV--------HILNMVTGIV O_cuniculus_ENSOCUP00000006175 EMDIV--VSEDLNGAVKFSSSLPYPNNL----NSILAQRLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKLV--------HILNMVTGTV X_tropicalis_ENSXETP00000036619 NEHIV--VYEDLMGAVKFSSVLPTPNHL----NSKLAGKLEHWLQCMLMWHQRQRG-------------------TDPQNPNV----GCFQALDSILSLKLL--------SVLNMVSGKV O_latipes_ENSORLP00000003067 NDHIV--VYEDLSGEVQFSKHLPQPNNL----NSLLLEKMERWLQLMLMWSPQNRG-------------------KDPNATPT----DCFSQLELILKLKLV--------HILNMMSAKI T_nigroviridis_ENSTNIP00000019003 NNDIV--VYEDLTGEVHYCKHLPQPNNL----NSLLSGKLERWLQLMLKWSPQERG-------------------KDPEAAPN----DCFSQLRLILQLKLV--------HVLNMMSAKI G_aculeatus_ENSGACP00000005440 KDDIV--VYEDLTGEVHFSKHLPQPNDL----NSLLSERLERWLQLMLKWCPQERG-------------------KDPNATPS----DCFSQLEVILQLKLV--------HVLNMISAKI T_rubripes_ENSTRUP00000041917 DNDIV--VYENLTREVHFSKHLPQPNNL----NSLLSLKLERWLQLMLKWSPQERG-------------------KDPGATPS----DCFSQLEVILQLKLV--------HVLNMMSAKI G_gallus_ENSGALP00000005196 PKHIF--ASEEMNGEVRFSTHLPQPHSI----CSLIVEPMESWLQLMLNWDPEQRGG-----------------GLDPETNSP----KCFLLMDHILNLKIV--------HILNMTSAKI T_rubripes_ENSTRUP00000022821 PKDIM--AVEELNGEVKFSTQLPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG-----------------RVSPESKKP----LCFEVLEQILSMKVV--------HILNMTTAQV R_norvegicus_ENSRNOP00000034134 PKCIF--ACEEMTGEVRFSSHLPQPNNL----CSLIVEPMESWLQLMLNWDPQQRGG-----------------PIDPPLKQP----KCFVLMDNILNLKIV--------HILNMTSAKI P_troglodytes_ENSPTRP00000055512 PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDFTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI H_sapiens_ENSP00000359424 PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLVVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI M_mulatta_ENSMMUP00000024306 PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI D_rerio_ENSDARP00000013115 PKDIM--AVEDMNGEVRFSTHLPYPNNL----SRTLLEPLEGLLQLMLKWDPVQRGL-----------------GLNTDSKQP----QCFVLLDQILSMKVV--------HILNMTTTQV C_familiaris_ENSCAFP00000014093 PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI B_taurus_ENSBTAP00000009985 PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI M_musculus_ENSMUSP00000026217 PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMESWLQLMLNWDPQQRGG-----------------PIDLTLKQP----RCFALMDHILNLKIV--------HILNMTSAKI M_domestica_ENSMODP00000013213 PKHIF--AFEEMTGEVRFSSHLPQPNSL----SSFIVQPMEQWLQLMLTWDPQQRGG-----------------SLDLPHKQP----ACFGQMEQILNLKIA--------HILNMTSAKI T_guttata_ENSTGUP00000004836 PKHIF--ASEEMNGEVRFSTHLPQPHSL----CGLIVEPMENWLQLMLNWDPQQRGG-----------------GSDAETGRP----RCFLMMDHILNLKIV--------HILNMTSAKI O_latipes_ENSORLP00000016017 PKDIM--AVEELNGEVRFSTHLPYPNNL----SRTLLEPMETLLQLMLKWDPVQRGG-----------------RVNSDTKKP----MCFEVLEQILSMRVV--------HILNMTTAQV G_aculeatus_ENSGACP00000005520 PRDIT--AVEEPNGEVTFSTHLPYPNNL----SSTMLGPIEKLLQLMLRWDPFHRGG-----------------PVNRETKRP----SCFEQLELILSMKVV--------HILNMTTAQV P_pygmaeus_ENSPPYP00000002975 PKCIF--ACEEMSGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI X_tropicalis_ENSXETP00000038296 HKHIY--AYEEMSGEIRFSSYLPQPNNL----CSIIVDKIETWLQLLLNWDPIQRGG-----------------GMD--CGRP----QCFVLMDQILNLKIV--------HILNMTSAKI T_nigroviridis_ENSTNIP00000014802 PKDIM--AVEELNGEVKFSTQLPYPNNL----SRTLLKPMEALLQLMLNWDPVQRGG-----------------RVNPETKKP----LCFEVLEQILSMKVV--------HILNMTTAQV A_carolinensis_ENSACAP00000011973 PKCIF--AWEEMTGEVRFSAHLPNPNSL----CSIIVELMESWLQLMLNWDPQQRGG-----------------GRDPETGNF----RCFQLMDHLLNLKIV--------HILNMTSAKI E_caballus_ENSECAP00000005937 PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMEHWLQLMLNWDPQQRGG-----------------PVDLTLKQP----RCFVLMDHILNLKIV--------HILNMTSAKI G_aculeatus_ENSGACP00000008884 PKDIV--AVEDMNGEVRFSTHLPYPNNV----SRPLLEPVESLLQMLLLWDAAARGG-----------------GLDPDTNKP----HCYTALQNILSLKVI--------HVLDMTSAQL T_rubripes_ENSTRUP00000036336 PKDIM--ATEDMNGEVRFSAHLHYPNNL----SRPLLEPVESLLQMLLLWDPAARGG-----------------TVDADTNKP----YCNTALQNILNLKVI--------HVLDMTSAQL O_anatinus_ENSOANP00000003934 PKHIF--ASEEMSGEVRFSSHLPQPNSL----CRLIVEPMENWLQLMLNWDPQQRGG-----------------GIDSSTKQP----RCFLLMDQILHLKIV--------HILNMTSAKI O_latipes_ENSORLP00000011761 PKDIM--AVEDMNGEVRFSAHLPYPNNL----SSPLLEPIESLLQMLLLWDPSTRGG-----------------GLDPETNKP----YFYSVLHNILSMKVI--------HVLDMTSAQL T_nigroviridis_ENSTNIP00000019642 PKDIM--ATEDMNGDVRFSAHLHYPNNL----SRPLLEPLESLLQMLLLWDPVARGG-----------------MLDTDTNKP----HCNTALQNILNMKVI--------HVLDMTSAQL T_guttata_ENSTGUP00000005662 ELDIV--VSEDLSGEVKFSSCLPCPNNL----NSVLSGRLEKWLQLMLMWHPRQRG-------------------TDPTYGPN----GCFKALDDILNLKV------------------- G_gorilla_ENSGGOP00000008804 PKCIF--ACEEMSGEVRFSSHLPQPNSL----CXXXXXXXXXXXXXXXXXXXXXXXX-----------------XXXXXXXXX----XXXXXXXXXXXXXIV--------HILNMTSAKI T_guttata_ENSTGUP00000016868 -----------------------------------------------------------------------------------------------VLFLQIV--------HILNMTSAKI O_cuniculus_ENSOCUP00000011297 PKCIF--ACEEMTGEVRFSSHLPQPNSL----CSLIVEPMENWLQLMLNWDPQQRGG-----------------PVDLTLKQP----KCFILMDHILNLKXX--------XXXXXXXXXX A_aegypti_AAEL003245-PA SSHIA--ITEDNRENYTYHSELFSENHI----SSVLKTYLEKWLTLALEWNPKQRGHV-FQIGDKEVTEQQLKSAKEPSNGQPVQVLKIFSMLDSILSKKIL--------TMFCLYDFRF A_gambiae_AGAP009166-PA SADIA--ITEDNRENYTYHTEIFAENHI----STCLRKQLERWLMLALEWNPKQRGYVPYSATVAEGTPPKSVTFAEDSRPGGSTVLKIFSLLDQILEKRIL--------VLFSLHDCRW A_aegypti_AAEL010548-PA SNHIA--SLKITGR--IYHSELFPENHI----SSVLKTYLEKWLTLALEWNPKQRGH--------------------PSNGQPVQVLKIFSMLDSILSKKIL--------TMFCLYDFRF D_melanogaster_FBpp0082690 AKCIAITEDPEDNTRFVNQFELPQTHHL----SRPWAAQFTKWLASPLNSNYKERGQ-----------------------LAANNVPVVFADLDKILNMNVL--------TIFAVNNCER T_rubripes_ENSTRUP00000005087 PTGAISGLQRVADGSIEWSYSLPHSCQL----SQGLKVLLVPVLAGIMEADQEKCWG------------------FD----------QFFTATTDILKRQPV--------HLFSLQQAMA D_rerio_ENSDARP00000014302 PAGTIAGVQKEEDGPIEWRDKLPLSCQL----SEGLKTQLVPVLANILLADDEKCWK------------------FP----------QFFSATNDILNRITI--------YIFSLQQATT D_rerio_ENSDARP00000074566 PAGTIAGVQKEEDGPIEWRDKLPLSCQL----SEGLKTQLVPVLANILLADDEKCWK------------------FP----------QFFSATNDILNRITI--------YIFSLQQATT T_nigroviridis_ENSTNIP00000010090 PTGAISGTQHVVDGSIEWGYNLPHSCQL----SQGLKAQLVPVLAGIMEADQEKCWG------------------FD----------QFFTATTDILQRQPV--------HLFSLQQAMA B_taurus_ENSBTAP00000046540 PAGAIAGTQRRENGPLEWSYTLPITCQL----SMGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRGVI--------HVFSLPQAVL P_pygmaeus_ENSPPYP00000000308 PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL E_caballus_ENSECAP00000000587 PAGAIAGTQRRENGPLEWSYSLPITCRL----SSGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRVIV--------HVFSLSEAVL H_sapiens_ENSP00000356087 PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL X_tropicalis_ENSXETP00000015947 PSGAISGVQRAENGPIEWSGELPVTCNL----SMGLQTLFTPVLANILEADQEKCWG------------------FE----------QFFAVTNDVFNRIVI--------HVFSLQQMTP A_carolinensis_ENSACAP00000012863 PTGAIAGVQEQENGAIIWTDELPISCQL----SLGLKRPLVPILANILEADQEECWS------------------FD----------QFFAEANDILHRTII--------HVFSLSQAVM M_mulatta_ENSMMUP00000038190 PAGAIAGAQRRENGPLEWSYTLPITCQL----SLGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRVVI--------HVFSLSQSVL G_aculeatus_ENSGACP00000000783 PSGTISGHQKCENGKIEWSTEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG------------------FD----------QFFAETNDILHRTVV--------YVFSLQQATL C_familiaris_ENSCAFP00000035372 PAGAIAGTQRRENGPLEWSYGLPITCRL----SPGLQSQLVPILANILEVEQAKCWG------------------FD----------QFFAETSDILQRVVV--------HVFSLSQAVL M_domestica_ENSMODP00000002458 LAAVCPGTQKRENGPLEWSYKLPITCRL----SLGLQAQLVPILASILEVDQEKCWG------------------FD----------QFFAETSDILQRIVV--------HVFSLPQAVL T_nigroviridis_ENSTNIP00000005945 PPGTISGHQKCENGKIEWSSEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG------------------FD----------QFFAETNDILHRTVV--------YVFSLQQATL M_musculus_ENSMUSP00000054126 PAGAISGTQKQENGPLEWSYSLPITCRL----SMGLQNQLVPILANILEVEEDKCWG------------------FD----------QFFAETSDILQRTVI--------HVFSLPQAVL T_guttata_ENSTGUP00000006693 PSGAISGIQKAENGPIEWSWEMPVSCSL----SKGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRIII--------HIFSLQQMTL A_carolinensis_ENSACAP00000003243 PSGAISGVQKAENGPIEWSREMPVSCSL----SKGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAESSDILHRIII--------HVFSLQQMTL R_norvegicus_ENSRNOP00000030127 PAGAISGTQKQENGPLEWSYSLPITCRL----SVGLQSQLVPILANILEAEQAKCWG------------------FD----------QFFAETSDILQRTVI--------HVFSLPQAVL O_cuniculus_ENSOCUP00000010441 PSGAISGVQKAENGPIDWSADMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA E_caballus_ENSECAP00000018587 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA M_mulatta_ENSMMUP00000010063 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA P_troglodytes_ENSPTRP00000008798 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMVI--------HIFSLQQMTA P_pygmaeus_ENSPPYP00000005386 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA H_sapiens_ENSP00000329967 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMVI--------HVFSLQQMTA C_familiaris_ENSCAFP00000000505 PSGAISGVQKAENGPIDWSRDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMII--------HVFSLQQMTA O_anatinus_ENSOANP00000008566 PAGAIAGVQKRESGPLEWSYDLPTTCQL----SGGLRAQLVPILANVLEVDQEKCWG------------------FN----------QFFAETSDTLHRVVV--------HVFSLPQAVL G_gallus_ENSGALP00000015982 PSGAISGIQKAANGPIEWSWEMPISCSL----SKGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRIII--------HIFSLQQMTL M_musculus_ENSMUSP00000020316 PSGAISGVQKAENGPIDWSGDMPLSCSL----SQGLQALLTPVLANILEADQEKCWG------------------FD----------QFFAETSDVLHRMVI--------HVFSLQHMTA G_aculeatus_ENSGACP00000000485 PMGAIAGIQRVEGGQIEWSYHLPHSCQL----SQGLAMHLVPILAGILEADQERCWG------------------FD----------QFFKATTDVLQRQPV--------HLFSLHQAMA D_melanogaster_FBpp0080920 ASGVISGTQLSENGPIEWSTTLPPHAHL----SQGLKTLVTPLLAGLLEENREKTWS------------------FD----------RFFHEVTLILRKRVI--------HVFFTNRTSS O_latipes_ENSORLP00000019746 PIHAIAGVQRVEGGPIEWSYHLPHSCQL----SRGLKVLLVPVLAGIMEADQERCWV------------------FD----------QFFTATTDILQRQPV--------HVFSLQQATA G_gallus_ENSGALP00000021757 PPGAIAGVQRQENGSIEWSYELPLTCQL----SVGLKDQLVPILANILEVDQEKCWG------------------FD----------QFLAETNDILHRIVV--------DVFSLQQASS A_aegypti_AAEL005359-PA APGVISGTQTSENGPIEWSRHLPPHCQL----KAGLKFLVTPLLAGLLEESQKRMWS------------------FD----------RFFYEVQHILNKKVL--------HIFYTNQATS B_taurus_ENSBTAP00000023134 PSGAISGVQKAENGPIDWSGDMPVSCSL----SRGLQVLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRMIV--------HVFSLQQMTA T_guttata_ENSTGUP00000001142 PPGAIAGIQRQENGTIEWSYELPITCRL----STGLKDQLIPILASILEVDQEKCWG------------------FD----------QFFAGTNDILHRIVV--------DVFSLQQASS A_gambiae_AGAP009565-PA APGVISGTQTSENGPIEWSKHLPAHCQL----KEGLKQLVTPLMAGLLEESQGRMWS------------------FD----------KFFLEVQNILNKTVL--------HIFYVNRATS R_norvegicus_ENSRNOP00000009260 PSGAISGVQKAENGPIDWSGDMPLSCSL----SQGLQALLTPVLANILEADQEKCWG------------------FD----------QFFAETSDVLHRMVI--------HVFSLQHMTA C_intestinalis_ENSCINP00000011687 PSGVISGVQHSERGSIEWSRELPKTCRL----SHGFKKIFTVVLSGILECNPHKIWT------------------FD----------RYFAEVEDILSKKVI--------NVFSVPNAML D_rerio_ENSDARP00000087779 PPGAISGHQKFENGKIEWSSEMPISCSLVCAYSRGLQSLLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRIVV--------YVFSLQQATL O_anatinus_ENSOANP00000015719 PSGAVSGVQKAENGPIDYSGDMPISCNL----SRGLQALLTPVLANILEADQEKCWG------------------FD----------QFFAETSDILHRIII--------HVFSLQQMTA P_pygmaeus_ENSPPYP00000021585 ---------------------VRFPSKL--------SSDLKDLLRSLLQVDLTKRFG------------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI T_rubripes_ENSTRUP00000005140 PPGTISGHQKCENGKIEWSNEMPVSCSL----SKGLQSLLTPVLANILEADQEKCWG------------------FD----------QFFAETNDILHRT-------------------- C_elegans_T25E12.4a ---------------------FMYPPTP----WKEISENAIEFINGLLQVKMSKRYT-----------------------------------VTKAQSQIWMQ-------NYTLWSDLRV H_sapiens_ENSP00000366488 ---------------------VRFPSKL--------SSDLKHLLRSLLQVDLTKRFG------------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI P_troglodytes_ENSPTRP00000035898 ---------------------VRFPSKL--------SSDLKDLLRSLLQVDLTKRFG------------------------------NLRNGVGDIKNHKWF--------ATTSWI--AI A_carolinensis_ENSACAP00000002909 ---------------------VKWPKNM--------SLHFKSFLQGLLMKNPHERLS-----------------------------------WPELLYHPFIA-------GKVTVIDDTV M_mulatta_ENSMMUP00000026815 ---------------------VRFPSQL--------SPDLKDLLRSLLQVDLTKRFG------------------------------NLKNGVGDIKNHKWF--------ATTNWI--AL A_carolinensis_ENSACAP00000008611 KNDWSEGYQLAGTMNFRWPQCVPNNLKT---LIPNASSEAIQLMRDMLQWDPKKRPT-----------------------------------ASQALRYPYFQVGQALG-PSRCIQEGGK O_latipes_ENSORLP00000008832 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI G_aculeatus_ENSGACP00000024909 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI P_pygmaeus_ENSPPYP00000023332 ---------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT-----------------------------------CQQALQHLWISGD-----TAFDRDILGS D_melanogaster_FBpp0081883 ---------------------YRVPYYI--------SMDCENLMRKFLVLNPAKRTS-----------------------------------LSAVMSDKWINLG-----HDESDRLRPF M_domestica_ENSMODP00000019211 ---------------------VRWPPTI--------SQCFKSFLQGLLTKDPRQRLS-----------------------------------WPELLYHPFIA-------GRVTMTSETV O_cuniculus_ENSOCUP00000002072 ---------------------YEFDSPF----WDDISESAKDFIRHLLERDPQKRFT-----------------------------------CQQALQHLWISGD-----AASDRDILGS D_rerio_ENSDARP00000013244 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI T_guttata_ENSTGUP00000006427 HPP------------------LKMSSKM--------SYLFHAFLHSCLDSDPSTRWT-----------------------------------ARELLQHPFLQ-------TAVSLSVL-- O_latipes_ENSORLP00000018527 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG------------------------------NLKNGVNDIKGHKWF--------AATDWI--AI M_domestica_ENSMODP00000023457 KNDWPEGYQLSSSMNFRWPQCIPNNLKS---LIPNASSEAIQLMRDMLQWDPKKRPT-----------------------------------ASQALRYPYFQVGHPLGSTPHSLQEPGK A_carolinensis_ENSACAP00000009974 ---------------------YEFLSPY----WDNISPAAKDLINRLLVVDPKKRYT-----------------------------------AQQVLQHLWI--------DTAGKNNSRN D_rerio_ENSDARP00000002825 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG------------------------------NLKNGVNDIKGHKWF--------STTDWI--AI A_aegypti_AAEL004761-PA KNDWPDGHKLAVTIQFRFPECPKIPLES---LVTRASSSGIQLLEDFLKWEPEKRPT-----------------------------------AQQSLKYPYFASVKQRT-SATIVGNGNV M_mulatta_ENSMMUP00000018568 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI T_rubripes_ENSTRUP00000013710 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRYG------------------------------NLKNGVNDIKGHKWF--------ATTDWI--AI P_troglodytes_ENSPTRP00000018062 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI H_sapiens_ENSP00000309591 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI T_nigroviridis_ENSTNIP00000013350 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI T_rubripes_ENSTRUP00000032222 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI O_anatinus_ENSOANP00000000884 V--------------------SSVPPGI--------SSGAVHFMHSLLEPDPGKRPA-----------------------------------IKEAMKDKWLN-------EGFNRKPLSS M_mulatta_ENSMMUP00000025345 ---------------------VTYPSAW--------SQEMASLLKKLLELNPDQRFS----------------------------------QLSDVQNFPYM--------NDINWD--AV E_caballus_ENSECAP00000019558 KTDWPEGYQLSSAMNFRWPQCVPNNLKT---LIPNASSEAIQLLRDMLQWDPKKRPT-----------------------------------ASQALRYPYFQIGHPLGSTTQSLQDSGK A_aegypti_AAEL007931-PA PPK------------------LKNSHKV--------SSRLQNFLDRMLVRDPVQRAT-----------------------------------AAELLAHPFLR-------QAGPPSLLVP C_familiaris_ENSCAFP00000024262 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLKNGVNDIKNHKWF--------ATTDWI--AI G_aculeatus_ENSGACP00000013822 ---------------------VRFPSHF--------SSDLKDLLRNLLQVDLTKRFG------------------------------NLRNGVNDIKGHKWF--------ATTDWI--AI B_taurus_ENSBTAP00000020711 KTDWPEGYQLSNAMNFRWPQCVPNNLKT---LIPNASSEAVQLLRDMLQWDPKKRPT-----------------------------------ASQALRYPYFQVGHPLGSTAHSLQESGK C_familiaris_ENSCAFP00000003279 KTDWPEGYQLSSAMNFRWPQCVPNNLKT---LIPNASSEAIQLLRDMLQWDPKKRPT-----------------------------------ASQALRYPYFQIGHPLGSTTQSLQDSGK 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPATQCISDGKLNEG-HTLDM----------DLVFLFD---NSKITYETQISPR---------- M_mulatta_ENSMMUP00000010949 HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPATQCISDGKLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- P_troglodytes_ENSPTRP00000034602 HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPATQCISDGKLNEG-HTLDM----------DLVFLFD---NSKITYETQISPR---------- C_familiaris_ENSCAFP00000008270 HTYPVTEDES--LQNLKARIQHDTGIPE--KDQ-------ELLQEAGLA---LIPDKPAAQCISDGKLNEG-RTLDM----------DLVFLFD---NSKIAYETQISPR---------- M_musculus_ENSMUSP00000033939 HTYPVTEDES--LQSLKTRIQEDTGILE--TDQ-------ELLQEAGLV---LLPDKPATQCISDSKTNEG-LTLDM----------DLVFLFD---NSKINYETQITPR---------- R_norvegicus_ENSRNOP00000025851 HTYPVMEDES--LQSLKTRIREDTGILE--TDQ-------ELLQEAGLV---LLPDKPATQCISDSKTNEG-LTLDM----------DLVFLFD---NSKMSYETQITPR---------- B_taurus_ENSBTAP00000049055 HTYPVTEDES--LQSLKARIRQDTGILE--EDQ-------ELLQEAGLA---LIPDKPAAQCLSDGKLNEG-RTLDM----------DLVFLFD---NSRVTYESQVSPQ---------- P_pygmaeus_ENSPPYP00000020804 HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPATQCVSDGKLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- O_anatinus_ENSOANP00000001111 HTYPVTEEES--LQSMKARIQADTKIPE--EDQ-------ELLQEAGLA---LFSDKPDTQGITDGKLNDG-RIWDM----------DLLFLFD---NSKVTYETQISPR---------- E_caballus_ENSECAP00000003662 HTYPVTEDES--LQSLKARIQQDTGIPE--EDQ-------ELLQEAGLA---LIPDKPATQCISDGKLNEG-RTLDM----------DLVFLFD---NSKIAYETQISPR---------- M_domestica_ENSMODP00000012792 HTYPIMEKES--LQSLKARIQADTGIPE--EDQ-------ELLQEAGLA---LFSDKPATQCIVDSKLNDD-RILDM----------DLIFLFD---NRKITYETQISPR---------- G_gallus_ENSGALP00000005924 HTYPVTEEET--LQTVKARIQSDTGIPE--QDQ-------ELLQEAGLA---LFTQKHT----ADSKVNDA-VVADT----------DLLFLFD---NQKVAYEAQVALR---------- G_gorilla_ENSGGOP00000006628 HTYPVTEDES--LQSLXXXXXXXXXXXX--XXX-------XXXXXXXXX---XXXXXXXXXXXXXXXLNEG-RTLDM----------DLVFLFD---NSKITYETQISPR---------- A_carolinensis_ENSACAP00000012680 HVYPLAEEET--LQSIKAKVEAETGIPE--QDQ-------ELLQEGGLA---LFPEKPDIQYTADIKLNDA-TAADI----------GLLFLFD---NRKVTYESQISPR---------- O_cuniculus_ENSOCUP00000006175 HSYPVSEDES--LQSLKARIQSDTGISE--QDQ-------ELLQEAGLA---LIPDKPATQCISDGKLNEG-RTLDM----------DLVFLFD---NSKVAYETQISPR---------- X_tropicalis_ENSXETP00000036619 HTYPVSENEN--LQNLKSRLEQDTGIPE--EEQ-------ELLQASGLA---LNPAQPLTQFVVDCTVNDG-RQGEG----------DLIFLFD---NRKTVYEPQISLP---------- O_latipes_ENSORLP00000003067 LTYSVADDET--VADLQLRIEKDTGITA--ASQ-------ELLLEAGLA---LEPHVPASQCAVDYSEVDG-RRRDL----------PLVFLFD---RSSCTYQPQFAPR---------- T_nigroviridis_ENSTNIP00000019003 LSYSVSEDET--VADLQLRIEADTNIPV--AKQ-------ELLLEAGLA---LEPQAPATQCAINYSEIDG-RRTDS----------PLVFLFV---RPPCSYEPQFAPR---------- G_aculeatus_ENSGACP00000005440 LTYSVSEEET--VADLQLRIEKDSNIPA--TNQ-------ELLLEAGLA---LEPHGLATQCAVDYTEIDG-RRTDS----------PLVFLFD---RSSCSYEPQFAPR---------- T_rubripes_ENSTRUP00000041917 LSYSVSDDET--VADLQLRIEKDTEIPV--VDQ-------ELLLEAGLA---LEPQALAMQCAIDYSQIDG-RRTDL----------PLVFLFV---RSTCSYEPQFAPR---------- G_gallus_ENSGALP00000005196 VSFLLHPEES--LHFLQNRIESETGIST--GNQ-------ELLLETGIC---LDPRKPASQCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- T_rubripes_ENSTRUP00000022821 HSFQLTADEN--LHSLQKRIEAETKIDV--ANQ-------ELLQETGVS---LDPRKPAAQCVLDGVLNEH-RGWDS----------YIVYLFD---KSITTYSGPFSAR---------- R_norvegicus_ENSRNOP00000034134 ISFLLPYDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- P_troglodytes_ENSPTRP00000055512 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- H_sapiens_ENSP00000359424 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- M_mulatta_ENSMMUP00000024306 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- D_rerio_ENSDARP00000013115 HSFLLSPDEG--LHSLQQRIENETKIEL--LNQ-------DLLQETGVM---LDPRKPAAQCVLDGV-----RGWDS----------YIVYLFD---KSLTKYMGPLTAR---------- C_familiaris_ENSCAFP00000014093 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- B_taurus_ENSBTAP00000009985 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSEMGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- M_musculus_ENSMUSP00000026217 ISFLLPCDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- M_domestica_ENSMODP00000013213 ISFLLFPEES--LHSLQSRIEHETGINT--ASQ-------ELLLEMGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKIVYEGPFASR---------- T_guttata_ENSTGUP00000004836 VSFLLHPEES--LHSLQNRIEFETGIST--GNQ-------ELLLETGIC---LDPRKPASQCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- O_latipes_ENSORLP00000016017 HSFQLSPDES--LHSLQKRIEGETKIEV--VNQ-------ELLHETGVS---LDPRKPAAQCALDGVKKSLKRGWDS----------YVVYLFD---KSLTKYSGPFSAR---------- G_aculeatus_ENSGACP00000005520 HSFQLDPEES--LHSLQKRIEAETRIEV--VNQ-------ELLQETGVS---LDPRKPAAQCVLDGV-----RGWDS----------YIVYLFD---KSINKYSGPLSAR---------- P_pygmaeus_ENSPPYP00000002975 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- X_tropicalis_ENSXETP00000038296 HSFHL-QEES--LHTLQSRIETETGIST--CNQ-------ELLLEMGVS---LDPRKPASQCVIDGV-----KGWDS----------YMVYLFD---KSKTVYEGPFQSR---------- T_nigroviridis_ENSTNIP00000014802 HSFQLAADEN--LHSLQKRIEAETKIEV--ANQ-------ELLQETGVS---LDPRKPAAQCVLDGV-----RGWDS----------YIVYLFD---KSITTYSGPFSAR---------- A_carolinensis_ENSACAP00000011973 LSFSLHPEES--LHSLQSRIESETGIST--GNQ-------DLLLEMGIC---LDPRKPASQCVIDGI-----RGWDS----------YMVYLFD---KSKTIYEGPFASR---------- E_caballus_ENSECAP00000005937 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- G_aculeatus_ENSGACP00000008884 HSLILGAEES--LHSLQLRLETHTQTHVSPLSQ-------ELLLETGIS---LDPRRPPAHCLPEGL-----RGWDS----------SLVFLFD---KSLTKYSGPLTAR---------- T_rubripes_ENSTRUP00000036336 HSLILGAEEN--LQSLHLRLEAQTQSHIPPLSQ-------ELLLETGVS---LDPRRPPSQCLPDGL-----QGCDS----------CIVFLFD---KSLNKYSGPLTAR---------- O_anatinus_ENSOANP00000003934 ISFLLLPDES--LHSLQSRIEQETGIST--GTQ-------ELLLEMGIS---LDPRKPASQCVIDGV-----RGWDS----------YMVYLFD---KSKIVYEGPFASR---------- O_latipes_ENSORLP00000011761 HSLDLGTDES--LLSLQLRLEAQTQAHISPQSQ-------ELLLETGNS---LDPRRPPIQFLPEGL-----RGWDN----------SIVFLFH---TSLNKYSGPLTAR---------- T_nigroviridis_ENSTNIP00000019642 HSLVLGAEEN--LQKKRWSL----------LFS-------PLL----------------------TL-----RGCDS----------STVFLFD---KSLNKYSGPLTAR---------- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ISFLLPPDES--LHSLQSRIERETGINT--GSQ-------ELLSETGIS---LDPRKPASQCVLDGV-----XXXXX----------XXXXXXX---XXXXXXXXXXXXX---------- T_guttata_ENSTGUP00000016868 VSFLLHPEES--LHSLQNRIEFETGIST--GNQ-------EMLLETGIC---LDPRKPASQCVIDGV-----RGWDS----------YMVYLFD---KSKTVYDGPFASR---------- O_cuniculus_ENSOCUP00000011297 XXXXXXXXXX--XXXXXXXXXXXXXXXX--XXX-------XXXXXXXXX---XXXXXXXXXXXXXXX-----RGCDS----------YMVYLFD---KSKTVYEGPFASR---------- A_aegypti_AAEL003245-PA LSIEIDETTD--LKTLCSAITSQTGIVR--EAI-------EFVLPLDQK---LDRVTATT------------KPIDL----------YLDGFHD----KPMLFIIKQG---AIIQADLKP A_gambiae_AGAP009166-PA IDLEVTPDTS--MAAVREHVYQLTGIPV--DEI-------EFILPLEQK---QPRVGSDT------------RPYDL----------YLPELQS---GKPMVYVAHRASRESIVQRDLKP A_aegypti_AAEL010548-PA LSIEIDETTD--LETLCSAITSQTGI---------------------------------------------------------------------------------------------- D_melanogaster_FBpp0082690 LEYAVSAEMT--MKDLIALIVLDTGMDE--KEL-------YFVLPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSN-----PPVMLYIFQVKKECDY----------------- T_rubripes_ENSTRUP00000005087 HCIYIHHYDT--VATFFEEVASQTGIGV--EQQ-------HLLYLGHALP--LEGSMKAVNLPHTS---PT----------------QPLTLLS--YGFEPNPSLPFRE-P------ETP D_rerio_ENSDARP00000014302 YSIYIQFHNT--VSIFFEDVQAQTGIEP--AAQ-------QYLFQGHPLI--LDPSMKVVNIPHTS---SD----------------KPMILIS--RRLERIIGYPFEE-P------ESP D_rerio_ENSDARP00000074566 YSIYIQFHNT--VSIFFEDVQAQTGIEP--AAQ-------QYLFQGHPLI--LDPSMKVVNIPHTS---SD----------------KPMILIS--RRLERIIGYPFEE-P------ESP T_nigroviridis_ENSTNIP00000010090 HCIYIHHYDT--VATFFEEVASQTGIAA--EQQ-------HLLYLGHELL--LEGSMKVVTLPHTS---PA----------------QPLLLLS--YSFEANHSLPFRELA------DTP B_taurus_ENSBTAP00000046540 HR-YVHAHNT--IAIFLEAVYEQTGVAP--QHQ-------EYLFEGHLCV--LEPGLSAQHIAHTT---AS----------------SPLTLFS--TASEPPKGLAFRD-P----ALDVP P_pygmaeus_ENSPPYP00000000308 HHIYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSVSAQHIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDIP E_caballus_ENSECAP00000000587 HHVYIHGHNT--IAIFLEAVYEQTNVAP--QHQ-------EYLFEGHLCV--LEPNLSAQHIAHTT---AS----------------SPLTLFS--MASETPKGLAFRD-P----ALDIP H_sapiens_ENSP00000356087 HHIYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSVSAQHIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDVP X_tropicalis_ENSXETP00000015947 HKIYINTYDK--VPDFHDLVYKQTKIPA--QNQ-------ELLFEGRRLV--LEQGRLAQHFPITT---EE----------------NPIFVLT--REMVSVIGLRFDE-I----VI--P A_carolinensis_ENSACAP00000012863 LHVYIHPYNT--AIKFLEEVFRQTSTAP--CHQ-------EYLFEGHSYE--LEPNLQVCHFPKTT---ET----------------CPFILMS--TDPEDPVGLRYRD-P----TLEFP M_mulatta_ENSMMUP00000038190 HHVYIHAHNT--IAIFQEAVHKQTSVAP--RHQ-------EYLFEGHLCV--LEPSISAQHIAHTT---AS----------------SPLTLFS--TA--IPKGLAFRD-P----ALDVP G_aculeatus_ENSGACP00000000783 HHIYIHEYNT--AALFQELLSRRTSIPL--HNQ-------ELLYEGRRLV--LDPNRQAKMFPKSS---RD----------------NPIMLVS--RESVATVGLIFED-P----SP--P C_familiaris_ENSCAFP00000035372 HHIYIHAHNT--IAIFLEAVYEQTSVAP--QHQ-------EYFFEGHLCV--LEPSLSAQHITHTT---AS----------------SPLTLFS--KASETPKGLAFRD-P----AQDIS M_domestica_ENSMODP00000002458 HHVYVHAHNT--IGIFLEAVYKQTSVEP--SHQ-------EYLFEGHPCL--LEPSLPAQFLAQTT---ED----------------SPLTLLN--EDSDNPTGLAFRN-P----SLDVP T_nigroviridis_ENSTNIP00000005945 HHVYIQEYNT--AVLFQELLSRRTSIPP--HNQ-------ELLYEGRRLS--LDSNRQAKTFPQTS---RD----------------NPIMLVS--RESVTTVGLIFED-P----SP--P M_musculus_ENSMUSP00000054126 HHVYIHAHNT--IAIFLEAVYEQTNVTP--KHQ-------EYLFEGHPCV--LEPSLSAQHIAHTA---AS----------------SPLTLFS--MSSDTPKGLAFRD-P----ALDVP T_guttata_ENSTGUP00000006693 HKVYIHNYNT--AAIFHELVYKQTKIPS--QNQ-------ELIYEGRRLI--LEPGRLAQHFPRTT---EE----------------NPIFVVS--REAVNIVGLIYEE-V----LL--P A_carolinensis_ENSACAP00000003243 HKIYIHMHND--AVMFHELVYKQTMIPA--NNQ-------ELIYEGRRLV--IEPSRLAQAFPRTT---ED----------------NPIIVVS--REAMDIIGLLYEE-I----LL--P R_norvegicus_ENSRNOP00000030127 HHIYIHAHNT--IAIFLEAVYEQTNVAP--KHQ-------EYFFEGHPCV--LEPSLSAQHIAHTA---AS----------------SPLTLFS--MASDTPKGLAFRD-P----ALDVP O_cuniculus_ENSOCUP00000010441 HKIYIHSYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTT---EE----------------NPIFVVS--REPLSTIGLIYEK-IHISVSL--P E_caballus_ENSECAP00000018587 HKIYIHSYNT--AAVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHLPKTT---ED----------------NPIFVVS--QEPLSAVGLIYEK-I----SL--P M_mulatta_ENSMMUP00000010063 HKIYVHSYNT--ATIFHELVYKQTKILS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P P_troglodytes_ENSPTRP00000008798 HKIYIHSYNT--ATIFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P P_pygmaeus_ENSPPYP00000005386 HKIYIHSYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P H_sapiens_ENSP00000329967 HKIYIHSYNT--ATIFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTT---EE----------------NPIFVVS--REPLNTIGLIYEK-I----SL--P C_familiaris_ENSCAFP00000000505 HKIYIHGYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLI--IEPGRLAQHFPKTT---EE----------------NPIFVVS--QEPLSTIGLIYEK-I----SL--P O_anatinus_ENSOANP00000008566 HHVYVHAHNT--TAVFLESVFKQTNIAP--DHQ-------EYLFEGHPCL--LEPSLPAQHLVKTS---AS----------------SPLTLLS--VEPKSPLGLTFRD-P----ALDIP G_gallus_ENSGALP00000015982 HKVYIHSYNT--AAIFHELVYKQTKIPS--QNQ-------ELIYEGRRLI--LEPGRLAQHFPRTT---EE----------------NPIFVVS--REAVNIVGLVYEE-V----LL--P M_musculus_ENSMUSP00000020316 HKIYIHSYNT--AAVFHELVYKQTKIVS--SNQ-------ELIYEGRRLV--LELGRLAQHFPKTT---EE----------------NPIFVTS--REQLNTVGLRYEK-I----SL--P G_aculeatus_ENSGACP00000000485 HCVYIHHYNT--VLMFLEEVASQTGIAV--QLQ-------HLLYLGHKLP--LEGNMKVANLPHTS---HD----------------RPLILLS---GPDTNGSFPFRE-P------DTP D_melanogaster_FBpp0080920 VEVFLEPDEQ--IDNFRERIFLQTEVPL--EKQ-------ILLFNNEHLEKKVTPRTIAKAFPATT---TD----------------QPIFLYS--NDDNNVQLPQQLDLP------KFP O_latipes_ENSORLP00000019746 HSIYMHHYKT--VMVFFEEVASQTGISI--QQQ-------HLMYLGHDLP--LEGNMKVVNLPCTS---PS----------------QPLILLS--NSAEASTGLFFRE-P------ESP G_gallus_ENSGALP00000021757 HRIYIHSYNT--TSKFLDAVFKQTDIVP--HHQ-------EYFFEGHPYE--LDPNLQAHNFCRTA---RH----------------NPLTLLSCAEQPEDVVGVRYRD-P----ALDFP A_aegypti_AAEL005359-PA IEVYMDPEES--FFNLKEHVMVQTKVPH--VAQ-------LLLLDSERFEQKVGVNSSGMYTSLKNIMRNT----------------NPVMLFN--IENNNVTLPGELELP------KFP B_taurus_ENSBTAP00000023134 HKVYIHGYNT--ATVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LEPGRLAQHFPKTS---EE----------------NPIFVVS--REPLSTIGLIYEK-I----SL--P T_guttata_ENSTGUP00000001142 HRIYIHSYNT--TTKFLDAVYKQTNIVP--HHQ-------EYFFEGHLYE--LDPNLQAHNFCKTT---ES----------------SPLTLLSTSEQPEDVVGVRYRD-P----VLEFP A_gambiae_AGAP009565-PA IEVYLEPEQT--LVHLLEHILAQTDVPQ--ASQ-------LLLLDNELFATKVDANTSARGYPPTD---PS----------------NPVMLFN--IENYNVILPTEWDLP------KFP R_norvegicus_ENSRNOP00000009260 LKIYIHSYNT--AAVFHELVYKQTKIIS--SNQ-------ELIYEGRRLV--LELGRLAQHFPKTT---EE----------------NPIFVTS--REQLNSIGLRYEK-I----SL--P C_intestinalis_ENSCINP00000011687 HKVYISPEKT--LVSFQEAVAELTEVRS--SKQ-------LLLFDGEQFE--MEQFVPVKSYPHTT---PE----------------HPLILFS--SDINDFQAITIPHTC------KPP D_rerio_ENSDARP00000087779 HHVYIHTYNT--ANLFQELLFRRTNITP--SHQ-------ELLYEGRRLV--LDPNRQAQTFPKTS---RD----------------NPIMLLC--RDPVNTVGLLFED-P----SP--P O_anatinus_ENSOANP00000015719 HKIYIHSYNT--AAVFHELVYKQTKILS--PNQ-------ELIFEGRRLV--LEPGRLAQHFPKTS---EE----------------NPIIIVS--RDPMSTVGLIYEK-I----SI--P P_pygmaeus_ENSPPYP00000021585 YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF------------------------------------------------------------- T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a LEKAVGQRFV--------------------THE-------SDDVRWQAYEKEHNVTPVYV------------------------------------------------------------ H_sapiens_ENSP00000366488 YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF------------------------------------------------------------- P_troglodytes_ENSPTRP00000035898 YEKKVEAPFI-------PKYTGPGDASNFDDYE-------EEELRISINEKCAKEFSEF------------------------------------------------------------- A_carolinensis_ENSACAP00000002909 DQGIVNPFTSKLPPDLQALKEQQAHSLTPPSGQ-------SKILRKARQKMAQEARRKEMGKPKASLKGEVSKESETYSRKACLAQTDSSRQHQKLPGMEEHLALGEKETEWEQKEPSSK M_mulatta_ENSMMUP00000026815 FEKKVEAPFI-------PKYTGPGDASNFDSYE-------EEEIRISVNEKCASKFAEF------------------------------------------------------------- A_carolinensis_ENSACAP00000008611 -QRDVPEKTQ----IHIKPIPP--------AQP-------PPKAQVRLSFRPFQQNQPSHSVIYPYKTGSSLSD---NLREDKPSQMALPNIRS-------------------------- O_latipes_ENSORLP00000008832 YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSFSEKCAKEFAEF------------------------------------------------------------- G_aculeatus_ENSGACP00000024909 YQKKVEAPFV-------PKFKGPGDTSNFDDYE-------EEEIRVSFNEKCGKEFAEF------------------------------------------------------------- P_pygmaeus_ENSPPYP00000023332 VSEQIQKNFA------RTHWKRAFNATSFLRHIRKLGQSPEGEGASEQGMARHSHSGLRAGQPPKW------------------------------------------------------ D_melanogaster_FBpp0081883 REKPMELQDAARFDLLMSMGHKRRDVEQSVKGQLFDDIYCTYMLLGVAKPRSSNRSTKPEAIPTVDLTTPAVSSPLPNITTPTVTIAHVTLALDKNPPIHSSSASGRPIAPRLANAPNTP M_domestica_ENSMODP00000019211 TSDLGTPFTSRLPLELQALKEEQTNWLTPKGGQ-------SRILRQARKRMAEDTRQKTHLNPGTSLE-QVEKASKAVPVAALLPRLGATSQDLDFLSRTPSPEDKKDWAEWEASEPPQP O_cuniculus_ENSOCUP00000002072 VSEQIQKNFA------RTHWKRAFNATSFLRHIRKLGQSPEGEQASQQTPACHSHPGLLTGQPPKW------------------------------------------------------ D_rerio_ENSDARP00000013244 YQKKVEAPFI-------PKCKGPGDTSNFDDYD-------EEEIRVSITEKCGKEFAEF------------------------------------------------------------- T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 FQKKVEAPFV-------PKFKGPGDTSNFDDYE-------EEEIRVSFSEKCAKEFAEF------------------------------------------------------------- M_domestica_ENSMODP00000023457 PQKEFHEKMG--PPPHMKPVPP--------AHP-------PAKPQPRISSRAHQPSQPPQHLIYPYKTEASPADPESQLPGDQPHPVHFPALHN-------------------------- A_carolinensis_ENSACAP00000009974 LQKEVTINL-------------------------------ERHFRSQRK----------------------------------------------------------------------- D_rerio_ENSDARP00000002825 YQRRVEAPFV-------PKCRGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF------------------------------------------------------------- A_aegypti_AAEL004761-PA QLPQIQQNGNGIPNARISIVDA------------------AQVENSGITSR-FSVNPNTVSVNNGNINGSIYKSISNSDLNDINSLLSLSRLSQ------------------------NP M_mulatta_ENSMMUP00000018568 YQRKVGLPSI-------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000013710 YQKKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF------------------------------------------------------------- P_troglodytes_ENSPTRP00000018062 YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFSEF------------------------------------------------------------- H_sapiens_ENSP00000309591 YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFSEF------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013350 YQRKVEAPFI-------PKCKGPGDTSNFDDYD-------EEEIRVSFTEKCAKEFAEF------------------------------------------------------------- T_rubripes_ENSTRUP00000032222 YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSITEKCAKEFAEF------------------------------------------------------------- O_anatinus_ENSOANP00000000884 ITYKNRFHPEDLNPLVLNYMADTMELSH------------TEIISVLISNRPSSIMASYSLLLKKLAKYHKEQ----------------------------------------------- M_mulatta_ENSMMUP00000025345 FQKRLIPGFI--PNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQVNRSPPNSGSRVSP------------------------------------------------- E_caballus_ENSECAP00000019558 PQKEVLEKAG--PPPYMKPVPP--------AQP-------PNKPHTRISSRQHQASQPLQHVLYPYKVEASRTDHA-HLPEDKPSPLLFPSLHT-------------------------- A_aegypti_AAEL007931-PA LMRGARHSNC-------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000024262 YQRKVEAPFI-------PKFKGPGDTSNFDDYE-------EEEIRVSINEKCGKEFTEF------------------------------------------------------------- G_aculeatus_ENSGACP00000013822 YQRKVEAPFI-------PKCKGPGDTSNFDDYE-------EEEIRVSFTEKCAKEFAEF------------------------------------------------------------- B_taurus_ENSBTAP00000020711 SQKDVLEKAA--APPHVKPVPP--------AQP-------PAKPHTRISSRQHQAGQPPQHLMYPYKAEAPRTD---HLPEDKPSPLLLPSLHP-------------------------- C_familiaris_ENSCAFP00000003279 AQKDVLEKAG--PPPHIKPVPP--------AQP-------PTKPHPRISSRQHQGSQAPQHLIYPYKAEASRTDHPNHLPEDKPSPLLFPSLHT-------------------------- 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 PQPESVSCILQE------------------------------------------------------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- M_mulatta_ENSMMUP00000010949 PQPESVSCILQE------------------------------------------------------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- P_troglodytes_ENSPTRP00000034602 PQPESVSCILQE------------------------------------------------------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- C_familiaris_ENSCAFP00000008270 PQPESVSCILQE------------------------------------------------------------PK-RNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- M_musculus_ENSMUSP00000033939 PQPESVSCILQE------------------------------------------------------------PK-RNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- R_norvegicus_ENSRNOP00000025851 PQPESVSCVLQE------------------------------------------------------------PK-RNLSFFQMRKVWGQVWHSIQTLKEDCNRLQQ-------------- B_taurus_ENSBTAP00000049055 PQPESVSCILQE------------------------------------------------------------PK-RNLPFFQLRKVWGQVWHSIQALKEDCSRLQQ-------------- P_pygmaeus_ENSPPYP00000020804 PQPESVSCILQE------------------------------------------------------------PK-RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- O_anatinus_ENSOANP00000001111 SHPESVSCILQE------------------------------------------------------------PK-KNLAFFQLRKVWGQVWHTIRTLKEDCNRLQQ-------------- E_caballus_ENSECAP00000003662 PQPESVSCILQE------------------------------------------------------------PK-RSLSFFQLRKVWGQVWHSIQTLKEDCSRLQQ-------------- M_domestica_ENSMODP00000012792 PPPESVSCILQE------------------------------------------------------------PK-RNLPFFQLRKVWGQVWHTIRTLKEDCSQLQQ-------------- G_gallus_ENSGALP00000005924 PHPESVDYILQD------------------------------------------------------------PK-KNLHFFQLRKVWGQIWHTIRMLKEDCNRLQQ-------------- G_gorilla_ENSGGOP00000006628 PQPESVSCIXXX------------------------------------------------------------XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- A_carolinensis_ENSACAP00000012680 PHPDSINCILQD------------------------------------------------------------PK-KTLAFFQLRKVWGQVWHSIRRLNEDFNQLQN-------------- O_cuniculus_ENSOCUP00000006175 PQPESVSCILQE------------------------------------------------------------PK-RNLPFFQLRKVWGQVWHSIQTLKEDCNRLQQ-------------- X_tropicalis_ENSXETP00000036619 AHPESVTVILQD------------------------------------------------------------PK-RPLTYTHLRRVWGQTWQTIRAMKEDCARLLH-------------- O_latipes_ENSORLP00000003067 TLPENIRFVQMD------------------------------------------------------------PK-HVLPYSPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- T_nigroviridis_ENSTNIP00000019003 VLPENIRFVQSD------------------------------------------------------------PK-HVLAYSPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- G_aculeatus_ENSGACP00000005440 TLPENIRFIQTC------------------------------------------------------------HK-PILAYSPLRRTCGQAWHTIRSLKDDWQRLQQ-------------- T_rubripes_ENSTRUP00000041917 TLPENISYVQSD------------------------------------------------------------PK-IVLAYRPLRRTCGQAWHTIRSLKEDWQRLQQ-------------- G_gallus_ENSGALP00000005196 SLSECVNYIVQD------------------------------------------------------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- T_rubripes_ENSTRUP00000022821 QLSDKVHTIVQD------------------------------------------------------------AK-KQLPLVVLKKIWGEAVSYICGLKEDYSRLFQ-------------- R_norvegicus_ENSRNOP00000034134 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPVTQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- P_troglodytes_ENSPTRP00000055512 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- H_sapiens_ENSP00000359424 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- M_mulatta_ENSMMUP00000024306 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIVQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- D_rerio_ENSDARP00000013115 TLPESVNFIVRE------------------------------------------------------------TK-TQLPLSTLKKVWGEAVSYICGLREDYSRLFQ-------------- C_familiaris_ENSCAFP00000014093 SLSDCVNYIVRD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- B_taurus_ENSBTAP00000009985 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- M_musculus_ENSMUSP00000026217 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- M_domestica_ENSMODP00000013213 SLSECVNYIVKD------------------------------------------------------------SK-IQLPVMQLRRVWAEAVHYVSGLKEDYSRLFQ-------------- T_guttata_ENSTGUP00000004836 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- O_latipes_ENSORLP00000016017 RLPEKVNTIVQE------------------------------------------------------------PK-TQLPLVVLKKVWGEAVSYICGLKEDYCRLFQ-------------- G_aculeatus_ENSGACP00000005520 KLPDKVNMIVQE------------------------------------------------------------AK-TELPLVALKMVWGEAVSYICGLKDDYSRLFQ-------------- P_pygmaeus_ENSPPYP00000002975 SLSDCVNYIVQD------------------------------------------------------------RQNTSFQLYRLRKVWAEAVHYVSGTKKNYSRLFQ-------------- X_tropicalis_ENSXETP00000038296 SLSECLNYIVQD------------------------------------------------------------SK-VQLPIPQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- T_nigroviridis_ENSTNIP00000014802 QLSDKVHTIVQE------------------------------------------------------------AK-KQLPLEVLKKIWGEAVSYICGLKEDYSRLFQ-------------- A_carolinensis_ENSACAP00000011973 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPILQLRKIWAEAVYYVIGLKEDYSRLFQ-------------- E_caballus_ENSECAP00000005937 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- G_aculeatus_ENSGACP00000008884 PLPDSVNFIVRE------------------------------------------------------------TK-TQLPLSALRKVWGEAVSYICGLKEDYIRLYQ-------------- T_rubripes_ENSTRUP00000036336 PLPDSVNFIVRE------------------------------------------------------------TK-TQLPLTALRKVWGEAVSYICGLKEDYIRLYR-------------- O_anatinus_ENSOANP00000003934 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPITQLRKVWAEAVHYVSGLKEDYSRLFQ-------------- O_latipes_ENSORLP00000011761 PLPESVNFIVRE------------------------------------------------------------TK-TQLPLSTLRKVWAEAVSYVCGLKEDYFRLYQ-------------- T_nigroviridis_ENSTNIP00000019642 PLPDSVNFIVRE------------------------------------------------------------TK-TQLPLTALRKVWGEAVSYICGLKEDYIRLYS-------------- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 XXXXXXXXXXXX------------------------------------------------------------XX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- T_guttata_ENSTGUP00000016868 SLSDCVNYIVQD------------------------------------------------------------SK-IQLPIPQLRKVWAEAVHYVIGLKEDYSRLFQ-------------- O_cuniculus_ENSOCUP00000011297 SLSDCVNYISED-------------------------------------------------------------------------------HYVWGLKEDYRKLFL-------------- A_aegypti_AAEL003245-PA QIPKSVTDVFQN------------------------------------------------------------IK-VKLKPHMLRQFVSNAWYFVTNEQRIYGTALD-------------- A_gambiae_AGAP009166-PA RIPKSITDVFQN------------------------------------------------------------IK-VKLKPHMLRQFIANAYYFIANEQRLYVLLLD-------------- A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 KIPEPILSILSRKF--------------------------------------------------------IANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVS-------------- T_rubripes_ENSTRUP00000005087 VIPPKFDVLADYNF----------------------------------------------------------TK-------VIVGAVHQYLMVTQLLRTHRELLLQ-------------- D_rerio_ENSDARP00000014302 PMPGKFDVVADFVF----------------------------------------------------------TK-------TIVKVIHQYLRIAYSLQEYRQFILQ-------------- D_rerio_ENSDARP00000074566 PMPGKFDVVADFVF----------------------------------------------------------TK-------TIVKVIHQYLRIAYSLQEYRQFILQ-------------- T_nigroviridis_ENSTNIP00000010090 VIPPKFDVLADYNF----------------------------------------------------------TK-------VMVGAVHQYLMSTQVLRSHRELLLQ-------------- B_taurus_ENSBTAP00000046540 KFVPKVDLQADYST----------------------------------------------------------AK-------GILGAGYQACGWHR-LCCGAGADGS-------------- P_pygmaeus_ENSPPYP00000000308 KFVPKVDLQADYNT----------------------------------------------------------AK-------GVLGAGYQALRLARALLDGQELMLR-------------- E_caballus_ENSECAP00000000587 KFVPKVDLQADYNT----------------------------------------------------------AK-------GVLGAGYQALRLAQALLAGQELMLR-------------- H_sapiens_ENSP00000356087 KFVPKVDLQADYNT----------------------------------------------------------AK-------GVLGAGYQALRLARALLDGQELMFR-------------- X_tropicalis_ENSXETP00000015947 KLHSHYDLDVDANM----------------------------------------------------------AK-------AVTGVACYYCRIAASLLLVLELMRK-------------- A_carolinensis_ENSACAP00000012863 RFLPKVDVIADCST----------------------------------------------------------AK-------GVLSATHQTLRISQSFLKDQELILR-------------- M_mulatta_ENSMMUP00000038190 KFVPKVDLQADYNT----------------------------------------------------------AK-------GVLGAGYQALRLSRVLLDGQELMLR-------------- G_aculeatus_ENSGACP00000000783 KVQPRYDLDLDASY----------------------------------------------------------AK-------TFAGDVGHLWKTSESLLVYQELVRK-------------- C_familiaris_ENSCAFP00000035372 KFFPKVDLQADYTT----------------------------------------------------------AK-------SILGAGYQALWLARTLLAGQEMMLR-------------- M_domestica_ENSMODP00000002458 KFVPKVDLQADYNT----------------------------------------------------------AK-------GVLSMGHQVLRISRALQDGQEMMLR-------------- T_nigroviridis_ENSTNIP00000005945 KVQPRYDLDLDASY----------------------------------------------------------AK-------TFAGDVGHLWKTSESLLVYQKLVRK-------------- M_musculus_ENSMUSP00000054126 KFVPKVDLQADYST----------------------------------------------------------AK-------GVLGAGYQALWLARVLLDGQALMLR-------------- T_guttata_ENSTGUP00000006693 KVHQRYDLDGDASM----------------------------------------------------------AK-------AVTGIVCYACRVASSLLLYQELMRK-------------- A_carolinensis_ENSACAP00000003243 KVHQRYDLDSDASM----------------------------------------------------------AK-------TVTGVVCYACRVARALLLYQELMRK-------------- R_norvegicus_ENSRNOP00000030127 KFVPKVDLQADYST----------------------------------------------------------AK-------GVLGAGYQALWLARVLLDGQALMLR-------------- O_cuniculus_ENSOCUP00000010441 KVHPRYDLDGDASM----------------------------------------------------------AK-------TITGVVCYACRIAGTLLLYQELMRK-------------- E_caballus_ENSECAP00000018587 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACRVTSTLLLYQELMRK-------------- M_mulatta_ENSMMUP00000010063 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- P_troglodytes_ENSPTRP00000008798 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- P_pygmaeus_ENSPPYP00000005386 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- H_sapiens_ENSP00000329967 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACRIASTLLLYQELMRK-------------- C_familiaris_ENSCAFP00000000505 KVHPRYDLDGDASM----------------------------------------------------------AK-------AITGVVCYACKIASTLQLYQELMRK-------------- O_anatinus_ENSOANP00000008566 KFVPKVDLLADYNT----------------------------------------------------------AK-------GGLGPGGGSLIWGGGGTRRWELMLR-------------- G_gallus_ENSGALP00000015982 KVHQRYDLDGDASM----------------------------------------------------------AK-------EVTRIVCYACRVANSLLLYQELMRR-------------- M_musculus_ENSMUSP00000020316 KIHPRYDLDGDASM----------------------------------------------------------AK-------AVTGVVCYACRTASTLLLYQELMRK-------------- G_aculeatus_ENSGACP00000000485 VIPSRFDVIADYNF----------------------------------------------------------SK-------VIVGVVHQYLRLVQSLHTHSGLLLQ-------------- D_melanogaster_FBpp0080920 VFPPNVSVENDASL----------------------------------------------------------AK-------SACSVGHECKRRVDIFTSMDILIKK-------------- O_latipes_ENSORLP00000019746 IIPSKFDVLADYNF----------------------------------------------------------SR-------IIVGVVHQYLRIVHLLHTHRQLLLQ-------------- G_gallus_ENSGALP00000021757 KFVPKVDVVADCSA----------------------------------------------------------AK-------SAVGAVHQALRIAQELRQCQELTVR-------------- A_aegypti_AAEL005359-PA SFPSGVSVENDASL----------------------------------------------------------AQ--------ACSVGHECKRRVENFSMLDTLMNK-------------- B_taurus_ENSBTAP00000023134 KVHPRYDLDGDASM----------------------------------------------------------AK-------AMTGVVCYACRIASTLLLYQELVRK-------------- T_guttata_ENSTGUP00000001142 KLVPRVDVVADCSA----------------------------------------------------------AK-------VGV------------------------------------ A_gambiae_AGAP009565-PA TFPNGISVENDASL----------------------------------------------------------AK-------VACSVGHECKRRVESLSLLDTLMNK-------------- R_norvegicus_ENSRNOP00000009260 KIHPRYDLDGDASM----------------------------------------------------------AK-------AVTGVVCYACRTAGTLLLYQELMRK-------------- C_intestinalis_ENSCINP00000011687 KVKPSLSLDNDSSL----------------------------------------------------------AK-------VCSSTLFDIRKSVSYLLLVQILIRL-------------- D_rerio_ENSDARP00000087779 KVQPRYDLDLDASY----------------------------------------------------------AK-------TFAGDVGYLWKTSDSLLLYQELVRK-------------- O_anatinus_ENSOANP00000015719 KVHPRYDLDSDASV----------------------------------------------------------AK-------AVTGVVCYACRVASSLLLYQELMRK-------------- P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 LQENWITQDYEREFQEMKPESRRSIDTVDLETEEMDSDEEWQHFIDATNSTHVHLSAPLSLLGDPAFVQRIRVRLKDSGQQVLEGMLEGASHLRPALHVISNLLGTCCDSDLLCSFCNDI M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 KMPQHKIDVATEKT--------------------------------------------------------------------------------NGELKPKNRRRW-------------- O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 TSTPPTGPPAKPT----------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019211 TREPQVTQEYDQEFPELKQEAEES-SVGTLEPEEPDSDSEWQHLLEPTAPSDIQLKAPLTLLCNPDFCQRVQNQLHGAGGQVLEGILDGASRLLPTLRVVKSLLTTCSDSALLYAFCREA O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 KIPQTKILAGMEHP--------------------------------------------------------------------------------NGEIKPKSRRRW-------------- A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA SMPEKRSSLDNGKL--------------------------------------------------------------------------------NDSAKSNGKYQS-------------- M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 KNPQAKILTGLEHK--------------------------------------------------------------------------------NGEIKPKSRRRW-------------- A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 KHPQAKILTGLEHK--------------------------------------------------------------------------------NGEIKPKSRRRW-------------- C_familiaris_ENSCAFP00000003279 KKPQSKMLAGLEPK--------------------------------------------------------------------------------NGEIKPKSRRRW-------------- 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV M_mulatta_ENSMMUP00000010949 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV P_troglodytes_ENSPTRP00000034602 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV C_familiaris_ENSCAFP00000008270 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV M_musculus_ENSMUSP00000033939 GQRAAMMSLL-------------RNNSCLSKMKNAMASTAQ---QLKAKLDF--FKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAV----------------EQ-CGR----ENDV R_norvegicus_ENSRNOP00000025851 GQRAAMMNLL-------------RNNSCLSKMKNAMASTAQ---QLKAKLDF--FKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAV----------------EQ-CGR----ENDV B_taurus_ENSBTAP00000049055 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV P_pygmaeus_ENSPPYP00000020804 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV O_anatinus_ENSOANP00000001111 GQRAAMMNLL-------------RYNSSLSKMKNSMASMSQ---QLKAKLDF--FKTSVQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----EAEV E_caballus_ENSECAP00000003662 GQRAAMMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV M_domestica_ENSMODP00000012792 GQRAAMMNLL-------------RNNSSLSKMKNLMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ESDV G_gallus_ENSGALP00000005924 GQRAAMMNLL-------------RYNSTLSKMKNSMASLSQ---QLKAKLDF--FKTSIQIDLEKYKEQIEFGITSEKLLFAWKEMEQAV----------------EL-CGR----EDDV G_gorilla_ENSGGOP00000006628 XXXXXXMNLL-------------RNNSCLSKMKNSMASMSQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----ENEV A_carolinensis_ENSACAP00000012680 GQRAAMRNLL-------------RHNSTLSKMKNNMASLSQ---QLKAKLDF--FKASIQIDLEKYNEQIQFGITSEKLLLAWKEMEQAI----------------EL-RGR----EEDV O_cuniculus_ENSOCUP00000006175 GQRAAMMNLL-------------RNNSCLSKMKNSMASISQ---QLKAKLDF--FKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAV----------------EL-CGR----EDEV X_tropicalis_ENSXETP00000036619 GQRTFMVNLL-------------RYNTELSKKKNLMTSEFE---QLKAKLDF--FRNSIQIDLEKYSEQMEFGITSEKLLSAWRETEQTV----------------EL-CGR----EREV O_latipes_ENSORLP00000003067 GQKAAIMSLL-------------RHNSSLSKQKNEMVSMHQ---RLTAKLEF--FTTSLHIDMDKYQEQTATGIASEKLMSVWREMEQTA----------------VSQCGH----QAKV T_nigroviridis_ENSTNIP00000019003 GQKAAIMSLL-------------RHNSSLSKQKNDMVSMYQ---RLMAKLDF--FTTSLHIDMDKYQEQTSTGIVSEKFLGTWRSMEQTA----------------VS-CS-----QAKV G_aculeatus_ENSGACP00000005440 GQKAAIMSLL-------------RYNSSLSKQKNEMVSMHQ---RLMAKLDF--FTTSLHIDVDKYQEQTATGIASEKLMGVWREMEQTA----------------VS-CG-----QAKV T_rubripes_ENSTRUP00000041917 GQKAAIMSLL-------------RHNSSLSKQKNDMVSMYQ---RLMAKLDF--FTTSLHIDMDKYQEQTSTGIVYEKFLGMWRSMEQTA----------------VT-CS-----QARV G_gallus_ENSGALP00000005196 GQRAAMLSLL-------------RYNANLIKMKNNMVSASQ---QLKAKLEF--FHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SH-CAQ----AEDI T_rubripes_ENSTRUP00000022821 GQRAAMLSLL-------------RYNTNLTRCKNNMFGFSQ---QLKAKLDF--FKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV R_norvegicus_ENSRNOP00000034134 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YSE----VGVI P_troglodytes_ENSPTRP00000055512 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI H_sapiens_ENSP00000359424 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI M_mulatta_ENSMMUP00000024306 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI D_rerio_ENSDARP00000013115 GQRAAMLSLL-------------RFNTNLTRYKNMMFSFSQ---QLKAKLDF--FKTSIQYDLEKYSDQMQYGISSEKMLKAWHENEERA----------------AA-FAQ----VAEI C_familiaris_ENSCAFP00000014093 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI B_taurus_ENSBTAP00000009985 GQRAAMLSLL-------------RYNTNLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI M_musculus_ENSMUSP00000026217 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YSE----VGVI M_domestica_ENSMODP00000013213 GQRAAMLSLL-------------RYNANLTKMKNTMISASQ---QLKAKLQF--FHQSIQLDLDRYSDQMTYGISSEKMLKAWKEMEEKA----------------IQ-CAQ----AGDI T_guttata_ENSTGUP00000004836 GQRAAMLSLL-------------RYNANLIKMKNNMVSASQ---QLKAKLEF--FHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SQ-CAQ----AEDI O_latipes_ENSORLP00000016017 GQRAAMLSLL-------------RYNTNLTRCKNSMFGFSQ---QLKAKLDF--FKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV G_aculeatus_ENSGACP00000005520 GQRAAMVSLP-------------RYNTNLNRCKNSMFGFSQ---QLKAKLDF--FKSSLPYDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV P_pygmaeus_ENSPPYP00000002975 GQKGLGLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGICQKKMLKAWKEMEEKA----------------IH-YAE----VGVI X_tropicalis_ENSXETP00000038296 GQRAAMLSLL-------------RFNTNLTKMKNTMVSASQ---QLGAKLQF--FKRSIEIDLERYSDQMAYGISSEKMLRAWKEMEDKA----------------VC-FGK----AGKI T_nigroviridis_ENSTNIP00000014802 GQRAAMLSLL-------------RYNTNLTRCKNNMFGFSQ---QLKAKLDF--FKSSIQYDLEKYSDQMHYGISSEKMLKAWQENEERA----------------AA-FAQ----VAEV A_carolinensis_ENSACAP00000011973 GQRAAMLSLL-------------RYNANLTKMKNNMVSASQ---QLRAKLKF--FQQSIHLDLERYSDQMTYGISSEKMLKAWKEMEEKA----------------LL-CEQ----AGDI E_caballus_ENSECAP00000005937 GQRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKA----------------IH-YAE----VGVI G_aculeatus_ENSGACP00000008884 GQRAAMLSLL-------------RYNTNLTRYKNLLFSQSQ---QLRAKLAI--FKTSIQNDLEQYTRQRHVGISSEKMLRTWQENEEKA----------------DG-FSK----VAEV T_rubripes_ENSTRUP00000036336 GQRAAILSLL-------------RYNTNLTRYKNLLFSHSQ---QLQAKLAF--FKTSIQQDLEQYSKQRQTGISSEKLLKTWQENQEKA----------------DE-FMK-VGLVADV O_anatinus_ENSOANP00000003934 GQRAAMLSLL-------------RYNANLTKMKNTMISASQ---QLKAKLQF--FHQSIQLDLDKYSDQMAYGISSEKMLKAWKEMEEKA----------------IH-CAQ----AGDI O_latipes_ENSORLP00000011761 GQRTAMLSLL-------------RYNTTLTKYKNELFSESH---KLQAKLAF--FKTSIQYDLEQYANQMKNGISSEKMWKTWQESREKV----------------DLLTKK----AADV T_nigroviridis_ENSTNIP00000019642 GQRAAILSLL-------------RYNTNLTRYKNLLFSCSQ---QLRAKLAF--FKTSIQQDLEQYSKQSQSGISSEKLLRTWQENQEKV----------------DE-FMK----VADV T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 XXXXXXXXXX-------------XXXXXXXXXXXXXXXXXX---XXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------XX-XXX----XXXX T_guttata_ENSTGUP00000016868 GQRAAMLSLL-------------RYNANVIKMKNNMVSASQ---QLKAKLEF--FHQSIRLDLERYSDQMAYGISSEKMLKAWKEMEEKA----------------SQ-CAQ----AEDI O_cuniculus_ENSOCUP00000011297 GLRAAMLSLL-------------RYNANLTKMKNTLISASQ---QLKAKLEF--FHKSIQLDLERYSEQMTYGIXXXXXXXXXXXXXXXX----------------XX-XXX----XXXX A_aegypti_AAEL003245-PA GIKNYGLML----------------NDQIVKGRDDVSKLNKVSYGISGGLEY--HKLSLIQAKEMAKVNQ---LPPGTIQQCFSVLEERC----------------TRMEAT----IGKL A_gambiae_AGAP009166-PA GVRNYGLTL----------------NDAIARRKEEIGRMNKVVYGIVGGVEY--HKLTVSHTRDALNAGKR--IPSASFETASHQWEEKC----------------SRVETN----VRKL A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 GINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLK---EAQAKIPS--RQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLRE--------------------------AKDM T_rubripes_ENSTRUP00000005087 GFYSYMMKL-----------------------QKECGEVMHSIAMITIRLQS--CLNLDHRIH---------------TLFRGHYASGNQ----SPADNSQKLK--SVHEHL-PIYAACI D_rerio_ENSDARP00000014302 GFNSYIEQT-----------------------SSEVIDVTHRISKVKMKLH---SSISTEKTL---------------HVFTQTFAHEFP----DFIDSKKKFP--LIEAELQQMCGRGI D_rerio_ENSDARP00000074566 GFNSYIEQT-----------------------SSEVIDVTHRISKVKMKLH---SSISTEKTL---------------HVFTQTFAHEFP----DFIDSKKKFP--LIEAELQQMCGRGI T_nigroviridis_ENSTNIP00000010090 GFYSYMMKL-----------------------RTECGEAMHSIAMVTIRLQS--CLSLEHRIR---------------LL--SHCPSGDQ----SPSESSQTLK--AVHEHL-PIYASCI B_taurus_ENSBTAP00000046540 GLHWFVEML-----------------------QATCRRTLELARMALLFLS---SSLGPERFS---------------GLAGVPELQDLK----RTAELRSRLR--NLAEVL-SRCSHNI P_pygmaeus_ENSPPYP00000000308 GLHWVMEVL-----------------------QATCRRTLEVARTSLLYLS---SSLGTERFS---------------SVAGTPEIQELK----AAAELRSRLR--TLAEVL-SRCSQNI E_caballus_ENSECAP00000000587 GLHWFVEIL-----------------------QATCRRTLEVTRMALLFLS---SSLGTDRFS---------------NGAGTPEIQELK----RATELRSQLR--TLAGVL-SRCSHNI H_sapiens_ENSP00000356087 GLHWVMEVL-----------------------QATCRRTLEVARTSLLYLS---SSLGTERFS---------------SVAGTPEIQELK----AAAELRSRLR--TLAEVL-SRCSQNI X_tropicalis_ENSXETP00000015947 GIRWLSEIL-----------------------KEEYNENVHRNTEVSLKLSF--CNRTIEKDL------KT-YEQ---LIQTSVEP--------EVYVIHGKLL--NLSSTQ-ESLKSSL A_carolinensis_ENSACAP00000012863 GLYWLRYVL----------------------------QVCNKISLIPVSFTFPDSLFTTSFVS---------------AFEKWLTVYSIN----GLLWTLSVLA--QISEEI-SRCSHSI M_mulatta_ENSMMUP00000038190 GLHWVMEVL-----------------------QATCRQTLEVARTSLLYLS---SSLGTERWV---------------SVAGMPEIQELK----VAAELRSRLR--TLAEVL-SRCSQNI G_aculeatus_ENSGACP00000000783 GVRGLIELM-----------------------KEDYSEILHKKSEVFHLCNF--CTQILEKTE------QL-FEA---LMQANVMSSEYD----EICDMHKKVL--RISGSL-EPIERTT C_familiaris_ENSCAFP00000035372 GLHWFVETL-----------------------QATCRRTLEVTRMALLFLS---SSLGTERFS---------------SVAGMPEMQELK----RVTELRSRLR--ALVEAL-SRCSHNI M_domestica_ENSMODP00000002458 GLHWVVEVL-----------------------KATCGRTLETTRTALLFLS---PSLGTDGFA---------------SMTGESEVPELK----EAGELRSKLQ--TINEVL-SRCSQNI T_nigroviridis_ENSTNIP00000005945 GVRGLIELI-----------------------KEDYSEILQKKSEVFHLCNY--CTQILERTE------QLWLEV---LMQANTMSSEYD----EISDMHKKIV--RISSSL-EPLERTS M_musculus_ENSMUSP00000054126 GLHWVLEVL-----------------------QDTCQQTLEVTRTALLYLS---SSLGTERFS---------------SGAGMPDVQERK----EATELRTRLQ--TLSEIL-SKCSHNV T_guttata_ENSTGUP00000006693 GIRWLIEII-----------------------KDDYNEIVHKKAEIVIRLDF--CSRNIEKAE------KI-YEN---LMQINLEASEVD----EISEIHTKLL--RLSSSQ-GTIETSL A_carolinensis_ENSACAP00000003243 GIRWLIEII-----------------------KEDYTETLHKKTEVVLKLEF--CNRSIEKAV------EI-YQN---MLQNNLAPSEVD----EISDIHSKVL--RLSSSR-VTIETSL R_norvegicus_ENSRNOP00000030127 GLHWVLVVL-----------------------QNTCQQTLEITRTALLFLS---SSLGTERLS---------------SGAGMLDIQELK----EATELRSRLQ--TFSEVL-SKCSHNV O_cuniculus_ENSOCUP00000010441 GIRWLXXXX-----------------------XXXXXXXXXXXXXXXXXXXX--XXXXXXXXX------XX-YEK---LMKINLEAAELG----EISDIHTKLL--RXXXXX-XXXXXXX E_caballus_ENSECAP00000018587 GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTM------KV-YEK---LIEINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL M_mulatta_ENSMMUP00000010063 GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL P_troglodytes_ENSPTRP00000008798 GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL P_pygmaeus_ENSPPYP00000005386 GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CVRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL H_sapiens_ENSP00000329967 GIRWLIELI-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL C_familiaris_ENSCAFP00000000505 GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL O_anatinus_ENSOANP00000008566 GLTWLVEML-----------------------KSSCGHSLEKTRMALLFLNH--SGQGQDRPQ---------------LTSGSCEEPERR----VVGELRARLQ--TISEIL-SGWPQSI G_gallus_ENSGALP00000015982 GIRWLIEII-----------------------KDDYNEMVHKKTEVVIRLDF--CSRNIEKAE------KI-YEN---LMQINLESSEVD----EISEINTKLL--RLSSSQ-GTIETSL M_musculus_ENSMUSP00000020316 GVRWLVELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKVNLEAAELG----EISDIHTKLL--RLSSSQ-GTIESSL G_aculeatus_ENSGACP00000000485 GYYSYMMMF-----------------------RGECEEAVHTIAMITIRLQC--CLTTEQRTH---------------TL--ACYDAENK----GSTESRQRLH--LVREHL-PIYSAGI D_melanogaster_FBpp0080920 GVEHFIEML-----------------------VTTITLLLKKTESFDNLLST--VIDYADVVH----------------SMARVTKGDQE-----IKTLLTALE--NVKSDF-DGAADVI O_latipes_ENSORLP00000019746 GYYTYMMKL-----------------------RADCSEALHSLSLITLRFQS--CFNAHNRIH---------------KLTRLFFVSPRL---PSFQPSSQLSP--QVRERL-PLYTAGI G_gallus_ENSGALP00000021757 GLHWVMIYT---------------------ALAASPARDDHSCSSLDIQDG---SHLASHRYE---------------AIPGGSALPALK----DVAAVRIRLQ--RVAEEL-SQCSHSI A_aegypti_AAEL005359-PA AVEQFAGLL-----------------------KNQLAKLCERVKHQEDIGSS--TREISDLVQ----------------IAVMN--SYQD----KASTIHTEMN--SLKAAF-QLVSDPV B_taurus_ENSBTAP00000023134 GIRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKINLEAAELG----EISDIHTKLL--RLSSSQ-GTIETSL T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA SVHQFSGFL-----------------------AGFLVKLLKRTRHLEDIEGL--ISELTKMFE----------------VAASNHETYQK----LGATILASYE--TQKSDF-QRVSEPI R_norvegicus_ENSRNOP00000009260 GVRWLIELV-----------------------KDDYNETVHKKTEVVITLDF--CIRNIEKTV------KV-YEK---LMKVSLDAAELG----EISDIHTKLL--RLSSSQ-GTIESSL C_intestinalis_ENSCINP00000011687 SVKWFVCYL-----------------------KSRVVKLKLLRSNLQCKVDC--LRTALEIFEEHYQRETSLLTVITNLVTSPPEVNELKLYFTQITEKAKILR--QIRTEF-DQLNEST D_rerio_ENSDARP00000087779 GVRGLNELI-----------------------RDEYSETMHKKTEVFHLCSH--CSQTLERSH------PA-IHP---YVQSFICSSVHP----SIHPSFHLFICSFIHPSI-HLFIHSS O_anatinus_ENSOANP00000015719 GVRWLIELI-----------------------REDYNETVHKKTEVVITLDF--CIRNIEKTR------KV-YEK---LMHINLESAELG----EISDIHTKLL--RLSSSR-GTIETSL P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 GLPQFLMQLVESILKSFNIKQQPWHITLLTDLMAVMTV------FFASDFNR--EKDGKKQSLQAFQSSANHFLTLLPALLAQPTDQEGRLREQSLVCFTHLCQSMDNACPSISIPFYTS M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 G-----------------------------------------------------HIDGTLKSSEDWEDLGGCEVAKN----DFKNKG-QG------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 --------------------------------RRTPARTPARKATNHTSGQGRPEPSSLPHTPQSKRASANMDVKPTLLSAQRQLAQTQKLANTPPRFQYPVAQTPNQAQGSSRRPTTLY M_domestica_ENSMODP00000019211 GLPGLLLNLLRHSQSSVNIQQQPWCGTFLRDLVATIQA------YFAGNFNL--EKSQTSDSLHVFQEAANLFLNLLGKLLAQPDDAEQTLRRDSLMCFTDLCKTMDGSNLAISKSFYCS O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 G-----------------------------------------------------PVSRSTKDSDDWDDLDDFDFNPSLTRTDLKNKKRQS------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA GINYSVL------------------NEMLNNYNLGINGGLSHGNQHQGRLN---RNSSITKSITDRSDSGVNDNGSSVTSYSIIKPAIVK---------------IEEKPTEVYVAGRKG M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 G-----------------------------------------------------LVSRSTKDSDDWADLDDLDFSPSLTRIDLKNKKRQS------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 G-----------------------------------------------------LVSRSTKDSDDWADLDDSDFSPSFTRIDLKN-KRQS------------------------------ C_familiaris_ENSCAFP00000003279 G-----------------------------------------------------LVSRSTKDSDDWADLDDLDFSPSLTRIDLKNKKRQS------------------------------ 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ M_mulatta_ENSMMUP00000010949 KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ P_troglodytes_ENSPTRP00000034602 KLLVERMM--A--------LQTDIV--------------------------EEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ C_familiaris_ENSCAFP00000008270 KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ M_musculus_ENSMUSP00000033939 KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ R_norvegicus_ENSRNOP00000025851 KVLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQDMVRLLLQAIQSFEKK------------ B_taurus_ENSBTAP00000049055 KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ P_pygmaeus_ENSPPYP00000020804 KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ O_anatinus_ENSOANP00000001111 EQLVGRMM--A--------LQTDIVDLQRSP----MGR---KQG-GNLDDLEEQARE-LY------------RKLREK---PRDQRTSGDSQEMVRLLLQAIQSFEKK------------ E_caballus_ENSECAP00000003662 RHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ M_domestica_ENSMODP00000012792 KLLVEQMM--A--------LQTDIVDLQRSP----MSR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQSFEKK------------ G_gallus_ENSGALP00000005924 DQLVKRMM--A--------LQTDIVDLQRSP----LGR---KQG-GTLEDLEEQARE-LY------------RRLREK---PRDQRTSGDSQEIVRLLLQAIQTFEKK------------ G_gorilla_ENSGGOP00000006628 KLLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTEGDSQEMVRLLLQAIQSFEKK------------ A_carolinensis_ENSACAP00000012680 DQLVKKTM--A--------LQTDIVDLQRIP----QGR---KQG-SSLDDLEEQARD-LY------------RKLREK---PRDQRTSGDSQEVVRLLLQAIQTFEKK------------ O_cuniculus_ENSOCUP00000006175 KHLVERMM--A--------LQTDIVDLQRSP----MGR---KQG-GTLDDLEEQARE-LY------------RRLREK---PRDQRTDGDSQEMVRLLLQAIQGFEKK------------ X_tropicalis_ENSXETP00000036619 QALVDKMM--A--------LQTDSVDLQRNP----LGR---KHR-GTLDDLEEQAKD-LY------------RRLRER---PRDQRTAGDSNEMVRLLIQAIQSFEKR------------ O_latipes_ENSORLP00000003067 SELEDEMM--Q--------LQPDIVDVQRQP----W-----RCG-EALDTLEGKAME-LF------------RKLREK---PRDQRCAGDGQEVMRLVLQAVQVYERK------------ T_nigroviridis_ENSTNIP00000019003 KELDEEMM--Q--------LQPEIVDVQRQP----W-----RSG-EALDTLEGKAME-LF------------RKLREK---PRDQRCSGDSQEVVRLVVQAVQFYEKK------------ G_aculeatus_ENSGACP00000005440 SELEEEMM--Q--------LQPDIVDVQRQP----W-----RSG-EALDTLEGKAME-LF------------RKLREK---PRDQRLPGDSQEVVRLVLQAVQFYERK------------ T_rubripes_ENSTRUP00000041917 SELEEEMM--Q--------LQPDIVDVQRQP----W-----RSG-EALDTLEGKAME-LF------------RKLREK---PRDQRCSGDSQEVVRLVVQAVHFYERK------------ G_gallus_ENSGALP00000005196 GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY------------KQLKTR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ T_rubripes_ENSTRUP00000022821 NHLDDEIL--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY------------KQLKMKCKTPETDMS-TDSTEMVKAIIQTVQNQDKV------------ R_norvegicus_ENSRNOP00000034134 GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PTDHSYSDSTEMVKIIVHTVQSQDRV------------ P_troglodytes_ENSPTRP00000055512 GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ H_sapiens_ENSP00000359424 GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ M_mulatta_ENSMMUP00000024306 GYLEDQIM--S--------LHAEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ D_rerio_ENSDARP00000013115 GHLDEEIM--A--------LHSEIVELQRSP----YAR---RQG-DVMEQLQEKAIE-LY------------KQLKAKCKMPDPQHGYSDSSEMVKVIVQTVQNQDRV------------ C_familiaris_ENSCAFP00000014093 GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ B_taurus_ENSBTAP00000009985 GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ M_musculus_ENSMUSP00000026217 GYLEDQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PPDHLYSDSTEMVKIIVHTVQSQDRV------------ M_domestica_ENSMODP00000013213 GYLDEQIM--S--------LHTEIVELQRSP----SAR---RQE-DVMESLEQKAID-LY------------KQLKPR----SPDHSYSDSSEMVKIIVLTVQNQDRV------------ T_guttata_ENSTGUP00000004836 GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY------------KQLKAR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ O_latipes_ENSORLP00000016017 SHLDDEIM--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY------------RQLKMKCKIPDSDVS-SDSSEMVKAIIQTVQNQDKV------------ G_aculeatus_ENSGACP00000005520 SHLDDEIM--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY------------KQMKMKCKTPEPDVS-SDSSQMVMAIIQTVQNQDKV------------ P_pygmaeus_ENSPPYP00000002975 GYLEDQIM--S--------LHAEIMELQKEP----LWK---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ X_tropicalis_ENSXETP00000038296 HFLDETIM--G--------LHTEIVELQKSP----CAR---RQG-DVMEHLEQRAME-LY------------KQLKPR----SPDKAYSDSTEMVKILVQTVQGQDRV------------ T_nigroviridis_ENSTNIP00000014802 NHLDDEIL--A--------LHSEIVELQRSP----YAR---RQG-DKMEQLEEKAIE-LY------------KQLKMRCKTPETDTS-TDSTEMVKAIIQTVQNQDKV------------ A_carolinensis_ENSACAP00000011973 GYLDEQIM--A--------LHTEIVELQRSP----HAR---RQG-DLMENLEQRAIE-LY------------KQLKRR----PPDHSYSDSTEMVKIIVQTVQSQDWV------------ E_caballus_ENSECAP00000005937 GNLEEQIM--S--------LHTEIMELQKSP----YGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ G_aculeatus_ENSGACP00000008884 GYLDEEIV--A--------LHSEIVELQRSP----FAR---RQG-DVMEQLEEKAIE-LY------------KQLKG----PDPPHGYSDSSDMVRMILQTVQNQDRV------------ T_rubripes_ENSTRUP00000036336 AHLDEEIV--A--------VHFEIVELQRSP----FAR---RQV-DVMEQLEEKAIE-LY------------KQLKAKC--PDPPHGYSDSSDMLKVILQMVQNQDRV------------ O_anatinus_ENSOANP00000003934 GYLDEQIM--T--------LHTEIVELQRSP----YAR---RQG-DVMETLEQKAID-LY------------KQLKHR----SPDHSYSDSTEMVKIIVQTVQSQDRV------------ O_latipes_ENSORLP00000011761 GFLDKEIL--G--------LHNEIVELQRSP----YAR---RQG-DVMEQLEKKAIE-LY------------RQLKAKCKSPDPPHGYSDSSDMVKTILQTVQNQDRV------------ T_nigroviridis_ENSTNIP00000019642 VHLDEEIV--A--------VHFEIVELQRSP----FAR---KQV-DVMEQLEEKAIE-LY------------KQLKG----PDPPHGYSDSSDMLKIILQMVQNQDRV------------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 XXXXXXXX--X--------XXXXXXXXXXXX----XGR---RQG-DLMESLEQRAID-LY------------KQLKHR----PSDHSYSDSTEMVKIIVHTVQSQDRV------------ T_guttata_ENSTGUP00000016868 GYLDEQIM--A--------LHTEIVELQKSP----YAR---RQG-EVMESLEQRAID-LY------------KQLKAR----PPDHAYSDSTDMVKIIVQTVQSQDRV------------ O_cuniculus_ENSOCUP00000011297 XXXXXXXX--X--------XXXXXXXXXXXX----XXX---XXX-XXXXXXXXXXXX-XX------------XXXXXX----XXXXXXXXXXXXXXXXXXXXXXXXXX------------ A_aegypti_AAEL003245-PA AEVADKIT--T--------RYESVLKRSREA----VAHQLLRGY-DQHDPFNLKSLDNRY------------EIARVQ--ILEKNTHEKSHIDMLQAVYECLKKRDIL------------ A_gambiae_AGAP009166-PA AEMADKIS--K--------RYESVLKRSRDA----LRHALLQEY-EQQDYFGLKTVEGRY------------EQTRAR--ILEKITNEKSHMDMSQAVYECLKRRDVL------------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 VKTTNQLRKEV--------CEKDLFDCARFY-----------------------------------------KKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEAR------------ T_rubripes_ENSTRUP00000005087 QEFQSRLD--H--------LQIEQAKLAEVL-------ASDKSC-QKMQVLLQKITA-IH------------QHYRKD---RLNGKLAYNDEQIHKFEKIHLSNHIKR------------ D_rerio_ENSDARP00000014302 REFQNILQ--Y--------LRVTLSKHSETL-------ANDKSI-QKMEVLLSQIVD-VH------------FQYFRD---RQTRKLGYNDEQIHKFEKLNLSSYLKK------------ D_rerio_ENSDARP00000074566 REFQNILQ--Y--------LRVTLSKHSETL-------ANDKSI-QKMEVLLSQIVD-VH------------FQYFRD---RQTRKLGYNDEQIHKFEKLNLSSYLKK------------ T_nigroviridis_ENSTNIP00000010090 QEFQSRLE--H--------LQIEQAKLAEAL-------ASDKSC-QRMQVLLQKITA-IH------------QHYRKD---RLNGKLAYNDEQIHKFEKIHLSTHIKR------------ B_taurus_ENSBTAP00000046540 TETQKTLS--D--------LCSELVKNRDQV------HED-RSI-QQIQCCLDKMYL-TY------------KQFKKS---RMRPGLGYNEEQIHKLDKAPAEREAVL------------ P_pygmaeus_ENSPPYP00000000308 TETQESLS--S--------LSRELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ E_caballus_ENSECAP00000000587 TETQMSLS--S--------LSSELVKNRDQV------HED-RST-QKIQCCLDKMYL-IY------------KQFKKS---RVRPGLGYNEEQIHKLDKVNFSHLAKR------------ H_sapiens_ENSP00000356087 TETQESLS--S--------LNRELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ X_tropicalis_ENSXETP00000015947 QEIKNKLTPGG--------VLMDSWINAEGT------HSADRNV-EKLQVLLSLITE-IY------------CQFKKD---KAQRRLLYNEEQIHKFDKQKMCIHSTK------------ A_carolinensis_ENSACAP00000012863 SEQQAALQ--G--------ILSEVGKKQNQM-------KEDRSI-QKMEACLDKMQL-IY------------AQFKKA---RKCPRLGYNEQQIHKLDKLNLGHSAKK------------ M_mulatta_ENSMMUP00000038190 TETQESLS--S--------LSQELVKSRDQV------HED-RSI-QQIQCCLDKMNF-IY------------KQFKKS---RMRPGLGYNEEQIHKLDKMNFSHLAKR------------ G_aculeatus_ENSGACP00000000783 QDIKSKFTSGG--------LLTDGWTQQVGT------HPEDRNV-EKIKVLLDAITA-IY------------QQFKKD---KAERRLPYNEEQIHKFDKQKLVLHATK------------ C_familiaris_ENSCAFP00000035372 TETQVSLS--N--------LSSELVKNRDQV------HAD-RSVIQQIQCCLDKMNL-IY------------KQFKKS---RMRPGLGYNEEQIHKLDKVNFSHLAKR------------ M_domestica_ENSMODP00000002458 VETQTSLI--S--------LSSELVKTWDQV------HED-RST-QQIQCCLDKMNL-IY------------KQFKKA---RMRPGLGYNEEQIHKLDKVNFGHLAKR------------ T_nigroviridis_ENSTNIP00000005945 QDIKTKFLPGG--------LLTDSWTQQVGT------HPEDRNV-EKIKVLLDAITA-IY------------QQFKKD---KAERRLPYNEEQIHKFDKQKLVLHASK------------ M_musculus_ENSMUSP00000054126 TETQRSLS--C--------LGEELLKNRDQI------HEDNKSI-QKIQCCLDKMHF-IY------------KQFKKS---RMRPGLSYNEEQIHKLDKVNFSHLAKR------------ T_guttata_ENSTGUP00000006693 QDIKTKLSPGG--------LLTDTWANQEGM------HPKDRNP-ERLQALLSSITD-IY------------YQFKKD---KAERRLPYNEEQIHKFDKQKLYLHATK------------ A_carolinensis_ENSACAP00000003243 QEIKNKLSPSG--------LLSDSWTNQEGT------HSKDRNP-ERLQVLLGSITD-IY------------HQFKKD---KAERRLLYNEEQIHKFDKQKLFLHATK------------ R_norvegicus_ENSRNOP00000030127 TETQRSLS--C--------LVGELLKSRDQI------HEDNRSI-QKIQCCLDKMHF-IY------------KQFKKS---RMRPGLSYNEEQIHKLDKVNFSHLAKR------------ O_cuniculus_ENSOCUP00000010441 XXXXXXXXXXX--------XXXXXXXXXXXX------XXXXXXX-XXXXXXXXXXXX-XX------------XXXXXX---XXXXXLAYNEEQIHKFDKQKLYYHATK------------ E_caballus_ENSECAP00000018587 QDIESKLSPSG--------LLTDAWAHQEGT------HPKDRHV-EKLQVLLSCITE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ M_mulatta_ENSMMUP00000010063 QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ P_troglodytes_ENSPTRP00000008798 QDIDSRLSPGG--------SLADGWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ P_pygmaeus_ENSPPYP00000005386 QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ H_sapiens_ENSP00000329967 QDIDSRLSPGG--------SLADAWAHQEGT------HPKDRNV-EKLQVLLNCMTE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ C_familiaris_ENSCAFP00000000505 QDIESKLSPGG--------LLSDTWAHQEGT------HPKDRHV-EKLQVLLNCITE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ O_anatinus_ENSOANP00000008566 QDTWSRLG--S--------MAAELAKSREQV------HEDRSSI-QQIECCLDKMQL-IY------------KQFKKA---RMRPGLGYNEEQIHKLDKVNFVHLAKR------------ G_gallus_ENSGALP00000015982 QDIKTKLSPGG--------LLADTWANQEGT------HPRDRNS-ERLQTLLSAITD-IY------------YQFKKD---KQERRLAYNEEQIHKFDKQKLYLHATK------------ M_musculus_ENSMUSP00000020316 QDISSRLSPGG--------LLADTWAHQEGT------HPRDRNV-EKLQVLLNCITE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ G_aculeatus_ENSGACP00000000485 HEFHSRLN--H--------LQIEQAKLAETL-------ANDQSC-QKMEMLKQRITT-IH------------QHYRKD---RQTGKLAYNDEQIHKFEKIHLSSHIKR------------ D_melanogaster_FBpp0080920 SQMHKHFVIDD--------ELNDQWTSSMHG---KKCPCKTRAS-AQAKYLVERLRD-SW------------QHLLRD---RATRTLTYNDEQFHALEKIKVDHNGKR------------ O_latipes_ENSORLP00000019746 KDCQNQME--H--------LLIEQAKLTETL-------ASDKSC-QKMEMLLQKIVA-IH------------QQYRKD---RLIGKLAYNDEQIHKFEKLHLLSHIKR------------ G_gallus_ENSGALP00000021757 FDFQGALD--G--------MVSELVQYGQQA------HEDK------------------------------------------------------------------------------- A_aegypti_AAEL005359-PA QQLHNRFVMEE--------SLSREWITAYRE---LRSPNKNRVN-EKAKYLVDRLRD-SW------------QHLLRD---RATRSLTHNDEQFHALEKIKITETGKR------------ B_taurus_ENSBTAP00000023134 QDIESKLSPGG--------LLADTWTHQEGT------HPKDRHV-EKLQVLLNCITE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA QQLYARFVKEE--------SLVREWNSGYRA---LRTPNKNRDS-EKAKSLVDRLRD-SW------------QHMLRD---RATRSLTYNDEQFHVLEKVKIAETGKR------------ R_norvegicus_ENSRNOP00000009260 QDINSRLSPGG--------SLADTWAHQEGT------HPRDRNV-EKLQVLLNCITE-IY------------YQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ C_intestinalis_ENSCINP00000011687 NQFDKLIIQEE--------IPSSIFVDEGSQ-------TNDRLE-ERMKVASEKSRE-IS------------RLFKTH---KKIRRLSHSDDQLHKFEKQRLAEVCEA------------ D_rerio_ENSDARP00000087779 VHSSIHSFICS--------FIHPSICSFIHSFIYLFIHSSVHSF-IHSSIHLLIYLF-IH------------SSVHPS---IHPSVQSFICSSVHP------SIHPSI------------ O_anatinus_ENSOANP00000015719 QDIKSKLSPGG--------LLADTWANQEGS------HPKDRNI-ERLQVLLNCIME-IY------------HQFKKD---KAERRLAYNEEQIHKFDKQKLYYHATK------------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 LLENHCPLLDT--------LCHGVSCEQIIQEVPPKEARSKQ---HWNELMGAAFAKALAASCVIPGRHTVCQKAKKKISQYIAEKLTEKENRLLASLILAVNHPASSLHGLKVLYACGH M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ----DEAFCRQ----------EVILDLKPSVCLGTGNSAP---SYLRQDTPTLQVSTAKQ------------HYLKHS---RYLPGISTRNNVMSSSSKDSIPSNLWP------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 EKAEPAVTPLL--------VPKSPAMGARLLERIPGGGAVEKTSDKPFTRQNVARATFHFGQARSGKRGGGSGNGAGGEEDSYQTPPLSADDTKPASRVGFFSKLTAR------------ M_domestica_ENSMODP00000019211 FLTTHKPVLDG--------LLHGMALPQLPLHTPPGAPQVSQPLREQDEDLPRAFATALAAICTLPVGLPGCWEAKEQVSKHLADQLTDDSSQLRPYLFSSLQHPSLSLHLLKVLYACCH O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ----DETLCR-----------QSVLDLKPSEPIGTGNSAPTHTSYQRQDTPTLR-SVAKQ------------HYLKHS---RYLPGIPIRNGILPNPGKDFLPPNSWS------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA EKVNDIYVTRNSGNGGRVGAIRAAVDSDDSSYFNSGFYLHKQTSNSKSDLFNE-------------------SFLNDS---KVYNAFSKQPVLLARKTDDDIKVNITK------------ M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ----DETLCRQ--------VFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLR-SAAKQ------------LYLKHS---RYLPGINMRNGVLPNPGKDFIPSNPWS------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ----DETLCR----------FESILDLKPSEPVGTGNSAPTQTSYPRRDTPTLR-SAAKQ------------HYLKHS---RYLPGINIRNGVLPNPGKDFIPPNPWS------------ C_familiaris_ENSCAFP00000003279 ----EETLCR----------FESVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLR-SAAKQ------------HYLKHS---RYLPGINIRNGILPNPGKDFIPSNPWS------------ 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ M_mulatta_ENSMMUP00000010949 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ P_troglodytes_ENSPTRP00000034602 ---------------------------------------------------------------VRV--IYTQLSKTVICKQKALELL------------PKVE---EVVSLMNE------ C_familiaris_ENSCAFP00000008270 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ M_musculus_ENSMUSP00000033939 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ R_norvegicus_ENSRNOP00000025851 ---------------------------------------------------------------VRV--IYSQLSKTVVCKQKALELL------------PKVE---EVVRLMNE------ B_taurus_ENSBTAP00000049055 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMSE------ P_pygmaeus_ENSPPYP00000020804 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---ELVSLMNE------ O_anatinus_ENSOANP00000001111 ---------------------------------------------------------------VRV--IYNQLSKTVVCKQKALELF------------PKVE---EVMSLMNE------ E_caballus_ENSECAP00000003662 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ M_domestica_ENSMODP00000012792 ---------------------------------------------------------------VRA--IYMQLSKTMVCKQKALELL------------PQVE---EVVSLMNE------ G_gallus_ENSGALP00000005924 ---------------------------------------------------------------VRV--IYAQLSKTVVCKQKALELF------------PRVE---KVMNLMNE------ G_gorilla_ENSGGOP00000006628 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ A_carolinensis_ENSACAP00000012680 ---------------------------------------------------------------VRL--LYVQLSNTVVCKQKALELF------------PKVD---EVMSLMKE------ O_cuniculus_ENSOCUP00000006175 ---------------------------------------------------------------VRV--IYTQLSKTVVCKQKALELL------------PKVE---EVVSLMNE------ X_tropicalis_ENSXETP00000036619 ---------------------------------------------------------------VIL--IYDQLSKTVACKHKALELS------------PKVK---EVMNLMRE------ O_latipes_ENSORLP00000003067 ---------------------------------------------------------------LKD--FYTHLSKTAVCRQRVMELL------------PKVE---GVVQKMAE------ T_nigroviridis_ENSTNIP00000019003 ---------------------------------------------------------------LRD--FYTHLSKTAACRQRVMELL------------PKVE---GVVQKMAE------ G_aculeatus_ENSGACP00000005440 ---------------------------------------------------------------LRD--FYTHLSKTAVCRQRVMELL------------PKVE---GMVQSMVE------ T_rubripes_ENSTRUP00000041917 ---------------------------------------------------------------LRD--FYTHLSKTALCRQRVMELL------------PKVE---GVVQKMAE------ G_gallus_ENSGALP00000005196 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKIE---VALNNIKE------ T_rubripes_ENSTRUP00000022821 ---------------------------------------------------------------LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLENIKD------ R_norvegicus_ENSRNOP00000034134 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ P_troglodytes_ENSPTRP00000055512 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ H_sapiens_ENSP00000359424 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ M_mulatta_ENSMMUP00000024306 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ D_rerio_ENSDARP00000013115 ---------------------------------------------------------------LRD--LYAHLSKILLSKQKIIDLF------------PKIE---RTLECIKE------ C_familiaris_ENSCAFP00000014093 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIKE------ B_taurus_ENSBTAP00000009985 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIKE------ M_musculus_ENSMUSP00000026217 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ M_domestica_ENSMODP00000013213 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKIE---VALNSIKE------ T_guttata_ENSTGUP00000004836 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PEIE---VALNNIKE------ O_latipes_ENSORLP00000016017 ---------------------------------------------------------------LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLENIKD------ G_aculeatus_ENSGACP00000005520 ---------------------------------------------------------------LKD--LYTHLSKILISKQKIIDLF------------PRIE---KTLESIKD------ P_pygmaeus_ENSPPYP00000002975 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ X_tropicalis_ENSXETP00000038296 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PQIE---MTVNNIKE------ T_nigroviridis_ENSTNIP00000014802 ---------------------------------------------------------------LKD--LYTHLSKILISKQKIIDLF------------PRIE---KALENIKD------ A_carolinensis_ENSACAP00000011973 ---------------------------------------------------------------LKE--LFRHLSKLLDCKQKIIDLL------------PKIE---VALNNIKE------ E_caballus_ENSECAP00000005937 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---MALSNIRE------ G_aculeatus_ENSGACP00000008884 ---------------------------------------------------------------LKD--LYTHLSTILVCKQRIVDLF------------PKLE---RAVENIKT------ T_rubripes_ENSTRUP00000036336 ---------------------------------------------------------------VKD--LYTHLSTILVCKRRIVDLF------------PKLE---TAVTDIKN------ O_anatinus_ENSOANP00000003934 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALNNIKE------ O_latipes_ENSORLP00000011761 ---------------------------------------------------------------LKD--LYTHLSTILVCKQHIVDLF------------PHLE---KALGDIKA------ T_nigroviridis_ENSTNIP00000019642 ---------------------------------------------------------------VKD--LYTHLSTILVCKRRIVDLF------------PKLE---TAVTDIKS------ T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PKVE---VALSNIKE------ T_guttata_ENSTGUP00000016868 ---------------------------------------------------------------LKE--LFGHLSKLLGCKQKIIDLL------------PEIE---VALNNIKE------ O_cuniculus_ENSOCUP00000011297 ---------------------------------------------------------------XXX--XXXXXXXXXXXXXXXXXXX------------XXXX---XXXXXXXX------ A_aegypti_AAEL003245-PA ---------------------------------------------------------------LRDYSFKELQQQLIDIRREMQEIR------------KALD---KAQEHAEK------ A_gambiae_AGAP009166-PA ---------------------------------------------------------------LRDAGFLELQRQLLDVRHEMQEIE------------KVLE---KVVELTEK------ A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ----------------------------------------------------------------------------------------------------------HLPKSIDH------ T_rubripes_ENSTRUP00000005087 ---------------------------------------------------------------VKSLFREDSVLRYKELLASTQIWSRSEPVPSLTPGTCSLV---GCKSKFKN------ D_rerio_ENSDARP00000014302 ---------------------------------------------------------------FKSLFKDDCFQKYLDVLNTTDRCS------------RALY---DMQTHLDK------ D_rerio_ENSDARP00000074566 ---------------------------------------------------------------FKSLFKDDCFQKYLDVLNTTDTCS------------RALY---DMQTHLDK------ T_nigroviridis_ENSTNIP00000010090 ---------------------------------------------------------------VKSLFREECVHRYKELLAT-------------------------------------- B_taurus_ENSBTAP00000046540 ---------------------------------------------------------------EEQKPQQSCVQKPPLWGLRWGHVA------------WLVD---ETRSHLRL------ P_pygmaeus_ENSPPYP00000000308 ---------------------------------------------------------------LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ E_caballus_ENSECAP00000000587 ---------------------------------------------------------------LLQVFQEECVQKYQTSLVTHGKHM------------RVVH---ETRNHLRL------ H_sapiens_ENSP00000356087 ---------------------------------------------------------------LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ X_tropicalis_ENSXETP00000015947 ---------------------------------------------------------------AYSLFKDECVGKYEGFRSKALDWM------------RKMI---HVRKQLFS------ A_carolinensis_ENSACAP00000012863 ---------------------------------------------------------------VILVFQDNSEHQYRAALSGHGTRM------------R-------------------- M_mulatta_ENSMMUP00000038190 ---------------------------------------------------------------LLQVFQEECVQKYQASLVTHGKRM------------RVVH---ETRNHLRL------ G_aculeatus_ENSGACP00000000783 ---------------------------------------------------------------ARSLFTEECAMKYRLFISKSEEWL------------KKVH---HVKKQLLG------ C_familiaris_ENSCAFP00000035372 ---------------------------------------------------------------LLQVFQEKCVQKYQTSLVTHGKWM------------REVH---ETRNHLRM------ M_domestica_ENSMODP00000002458 ---------------------------------------------------------------LLVLFQEDCVQKYQAALLTHGKRM------------RTVH---ETRKHLRL------ T_nigroviridis_ENSTNIP00000005945 ---------------------------------------------------------------ARSLFTEECAMKYRLFISKSEEWL------------RKVH---HVRKQLLT------ M_musculus_ENSMUSP00000054126 ---------------------------------------------------------------LLQVFQEECVQTYQVSLVTHGKRM------------RQVQ---RAQNHLHL------ T_guttata_ENSTGUP00000006693 ---------------------------------------------------------------AIALFKDECVSKYDAFLDKAEDWT------------RQAIDFFNIWKQLLA------ A_carolinensis_ENSACAP00000003243 ---------------------------------------------------------------AMTLFKEECVSKYEAFLDKAEDWT------------RQDPFMHHLRKQLMT------ R_norvegicus_ENSRNOP00000030127 ---------------------------------------------------------------LLQVFQEECAQTYQVSLVTHGKRM------------RQVQ---KAQNHLHL------ O_cuniculus_ENSOCUP00000010441 ---------------------------------------------------------------AMTHFSDECVKKYEAFLDKSEEWM------------RKML---HLRKQLLS------ E_caballus_ENSECAP00000018587 ---------------------------------------------------------------AMTHFTDECVKKYEVFLDKSEEWM------------RKML---HLRKQLLA------ M_mulatta_ENSMMUP00000010063 ---------------------------------------------------------------AMTHFTDECVKKYEAFLSKSEEWM------------RKML---HLRKQLLS------ P_troglodytes_ENSPTRP00000008798 ---------------------------------------------------------------AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ P_pygmaeus_ENSPPYP00000005386 ---------------------------------------------------------------AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ H_sapiens_ENSP00000329967 ---------------------------------------------------------------AMTHFTDECVKKYEAFLNKSEEWI------------RKML---HLRKQLLS------ C_familiaris_ENSCAFP00000000505 ---------------------------------------------------------------AMTHFTDECVKKYETFLDKSEEWM------------RKML---HLRKQLLS------ O_anatinus_ENSOANP00000008566 ---------------------------------------------------------------LLRIFQDDCVHKYQEALTMHGQRM------------REVH---EIRKHLQL------ G_gallus_ENSGALP00000015982 ---------------------------------------------------------------AIALFKDECVSKYDAFLDKAEDWT------------RKML---HTRKQLLA------ M_musculus_ENSMUSP00000020316 ---------------------------------------------------------------AMSHFSEECVRKYEAFKDKSEEWM------------RKML---HLRKQLLS------ G_aculeatus_ENSGACP00000000485 ---------------------------------------------------------------VKSLLREDCVLRYKELLATTKKWS------------SVLL---EMKTRLQD------ D_melanogaster_FBpp0080920 ---------------------------------------------------------------IKALLLDNVNPTVAQIAECLADWY------------KLAQ---TVYLKTQI------ O_latipes_ENSORLP00000019746 ---------------------------------------------------------------VKSVFREECVQRYKELLGSTKTWS------------RALQ---EMENRLLG------ G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ---------------------------------------------------------------VKTLLNDDVRPAVEQEAESLADWY------------KKAQ---TIFLQTKF------ B_taurus_ENSBTAP00000023134 ---------------------------------------------------------------AMTHFTDECVKKYEAFLDKSEEWM------------RKML---HLRKQLLS------ T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ---------------------------------------------------------------LKTLLNDGVRQAVEQEAECLADWY------------KKAQ---TIFLQTQF------ R_norvegicus_ENSRNOP00000009260 ---------------------------------------------------------------AMTHFTDECVRKYEAFKDTSEEWM------------RKML---HLRKQLLS------ C_intestinalis_ENSCINP00000011687 ---------------------------------------------------------------SVTLFTDKSVPGCKRLHKESINWF------------SNMN---EYQKKLWN------ D_rerio_ENSDARP00000087779 ---------------------------------------------------------------HPSFHLFICSFI-------------------------------HPSIHLFI------ O_anatinus_ENSOANP00000015719 ---------------------------------------------------------------AMSQFTDECIEKYEVFLDKAEEWM------------RKML---HLRKQLLT------ P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 VSQTLCHHL-ATPEMLNSLICHLQGKVFIHSYLCYKENCLVLFSLLMLQLQFLPSQTYLIRN-LGTACTHSIPNRRVSAAALLLTYFIQHGAAVKLRWEEALTAIATAFTESAEPCLPPP M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 VNENLCRRLDQEPLALESLLLLVQGKVDVIDPEETAEATLHLLSLLVLRLQVLPPGVKKIGNELAVLFVHSPVVSLVSAAAGLLSQLSQQGVAFNLQPKEWIAAAAHALSAPAE--LPP- O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ----------------------------------------------------------------NPLLNRGLQSNFSRSWEPVNGNS--------------------------------- M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- M_mulatta_ENSMMUP00000010949 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- P_troglodytes_ENSPTRP00000034602 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- C_familiaris_ENSCAFP00000008270 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- M_musculus_ENSMUSP00000033939 ----------------------DERTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- R_norvegicus_ENSRNOP00000025851 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- B_taurus_ENSBTAP00000049055 ----------------------DEKMVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- P_pygmaeus_ENSPPYP00000020804 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- O_anatinus_ENSOANP00000001111 ----------------------DEKTVVQL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- E_caballus_ENSECAP00000003662 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- M_domestica_ENSMODP00000012792 ----------------------DEKTVVQL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- G_gallus_ENSGALP00000005924 ----------------------DEETVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--ES----------------------------------------------- G_gorilla_ENSGGOP00000006628 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- A_carolinensis_ENSACAP00000012680 ----------------------DEKTVVGL-QEKRQKELWNLLK--------IAC---NKVRGPVSGSP--DS----------------------------------------------- O_cuniculus_ENSOCUP00000006175 ----------------------DEKTVVRL-QEKRQKELWNLLK--------IAC---XXXXXXXXXXX--XX----------------------------------------------- X_tropicalis_ENSXETP00000036619 ----------------------DEKMVVKR-QEKRQQELWNLLK--------IAC---SKVRGPVSGSP--DS----------------------------------------------- O_latipes_ENSORLP00000003067 ----------------------SEQILMSL-QERRQKELWNLLK--------VAC---SKVRSPVSGSP--DG----------------------------------------------- T_nigroviridis_ENSTNIP00000019003 ----------------------SEQVLMHL-QEKRQRELWNLLK--------VAC---SKVRSPVSGSS--D------------------------------------------------ G_aculeatus_ENSGACP00000005440 ----------------------SEQVLMSL-QERRQRELWNLLK--------VAC---SKVRSPVSGSP--DG----------------------------------------------- T_rubripes_ENSTRUP00000041917 ----------------------SEQVLIRL-QEKRQRELWNLLK--------VAC---SKVRSPVSGSS--D------------------------------------------------ G_gallus_ENSGALP00000005196 ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSSSRSLVSSSL--EG----------------------------------------------- T_rubripes_ENSTRUP00000022821 ----------------------ADTTVMQM-QIKRQREFWHLLK--------IAC-AQNSSRSSMAASP--ES----------------------------------------------- R_norvegicus_ENSRNOP00000034134 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- P_troglodytes_ENSPTRP00000055512 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- H_sapiens_ENSP00000359424 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- M_mulatta_ENSMMUP00000024306 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- D_rerio_ENSDARP00000013115 ----------------------ADTTVMQM-QIKRQREFWHLLK--------IAC-AQNTTRSSVSQSG--EM----------------------------------------------- C_familiaris_ENSCAFP00000014093 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- B_taurus_ENSBTAP00000009985 ----------------------ADSTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- M_musculus_ENSMUSP00000026217 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGYSL--EG----------------------------------------------- M_domestica_ENSMODP00000013213 ----------------------ADNMVMLM-QGKRQREIWHLLK--------IAC-TQSSARSLVGTSL--EG----------------------------------------------- T_guttata_ENSTGUP00000004836 ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSSSRSLVSSSL--EG----------------------------------------------- O_latipes_ENSORLP00000016017 ----------------------ADNTVMQM-QIKRQREFWHLLK--------IAC-AQNSSRNSIAVSP--ES----------------------------------------------- G_aculeatus_ENSGACP00000005520 ----------------------ADNTVMQM-QIKRQREFWHLLK--------IAC-AQNLTRNSIAASP--ES----------------------------------------------- P_pygmaeus_ENSPPYP00000002975 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- X_tropicalis_ENSXETP00000038296 ----------------------ADSSLMQM-QAKRQREIWHLLK--------IAC-TQSSARSLGPASV--ET----------------------------------------------- T_nigroviridis_ENSTNIP00000014802 ----------------------ADTTVMQM-QTKRQREFWHLLK--------IAC-AQNSSRSSIAASP--ES----------------------------------------------- A_carolinensis_ENSACAP00000011973 ----------------------ADNSVMQM-QGKRQKEIWHLLK--------IAC-TQSSAKSPVSSN----G----------------------------------------------- E_caballus_ENSECAP00000005937 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- G_aculeatus_ENSGACP00000008884 ----------------------AEAAVMQM-QMKRQKEFWYLLK--------IAC-NNTPTQSLMQQPT--YC----------------------------------------------- T_rubripes_ENSTRUP00000036336 ----------------------AEAGVVQM-QMKRQKEFWFLLK--------IAC-TVKMTRALVKRVA--NT----------------------------------------------- O_anatinus_ENSOANP00000003934 ----------------------ADNTVMLM-QGKRQREIWHLLK--------IAC-TQSSARSLVGSSL--EG----------------------------------------------- O_latipes_ENSORLP00000011761 ----------------------TENTVIQM-QKRRQKEFWYLLK--------VAC-VSNTICGCVFRN---------------------------------------------------- T_nigroviridis_ENSTNIP00000019642 ----------------------AETGVMQM-QMKRQKEFWFLLK--------IAC-VSTQKCLVGNAVS--HT----------------------------------------------- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ----------------------ADNTVMFM-QGKRQKEIWHLLK--------IAC-XXXXXXXXXXXXX--XX----------------------------------------------- T_guttata_ENSTGUP00000016868 ----------------------ADNSVMQM-QGKRQREIWHLLK--------IAC-TQSSSRSLVSSSL--EG----------------------------------------------- O_cuniculus_ENSOCUP00000011297 ----------------------XXXXXXXX-XXXXXXXXXXXXX--------XXX-TQSSARSLVGSSL--EG----------------------------------------------- A_aegypti_AAEL003245-PA ----------------------FKKDLAKM-IVEHNNSVWSLLN--------QGS-TSN--TSNPAVSTYNGN----------------------------------------------- A_gambiae_AGAP009166-PA ----------------------YKRELARL-TLEHQDEVWKMLSS--VDANGQAV-TTNGTLSNGGGTPHGPC----------------------------------------------- A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ---------------------------MHYLYFKTKESIPVLLQQ--FCDIKKEIFQINLQMLMSASSTPPPK----------------------------------------------- T_rubripes_ENSTRUP00000005087 ---------------------------ADP-AAGVQLFLHRLVG---------------RLGDEILYSLQSNQ----------------------------------------------- D_rerio_ENSDARP00000014302 ----------------------FRDTLLQR-IQDLKAHEILQNK---------------VL-ERVVHRAVQQP----------------------------------------------- D_rerio_ENSDARP00000074566 ----------------------FRDTLLQR-IQDLKAHEILQNK---------------VL-ERVVHRAVQQP----------------------------------------------- T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ----------------------VGCSVAAC-NTEAQGAQESLSK---------------IL-DRLSHQLLQER----------------------------------------------- P_pygmaeus_ENSPPYP00000000308 ----------------------VGCSVAAC-NTEAQGVQESLSK---------------LL-EELSHQLLQDR----------------------------------------------- E_caballus_ENSECAP00000000587 ----------------------VGCSVAAC-NTEAQGAQESLSK---------------LL-DRLSQQLLQDR----------------------------------------------- H_sapiens_ENSP00000356087 ----------------------VGCSVAAC-NTEAQGVQESLSK---------------LL-EELSHQLLQDR----------------------------------------------- X_tropicalis_ENSXETP00000015947 ----------------------LKSQCFEI-EEEVSKCQHYINQ---------------YQ-EKMSPKMFA-A----------------------------------------------- A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ----------------------VSCSVAAC-NTEAQGVQESLSK---------------IL-EELSHQLLQDR----------------------------------------------- G_aculeatus_ENSGACP00000000783 ----------------------LSGQLISI-EKEVTMLMERAIK---------------LQ-EHLPQKVLPLV----------------------------------------------- C_familiaris_ENSCAFP00000035372 ----------------------VSCSVAAY-NTEAQGVQESLSK---------------IL-DWLSHQHLQDR----------------------------------------------- M_domestica_ENSMODP00000002458 ----------------------VSSSVTAC-KAEAQEAQGQLSK--------KRISSSQAL-DRLSRRLWQGR----------------------------------------------- T_nigroviridis_ENSTNIP00000005945 ----------------------LSAQLIGI-EKEVAMLMERGIK---------------LQ-EQLPQKVLPLV----------------------------------------------- M_musculus_ENSMUSP00000054126 ----------------------IGHSVATC-NSEARGAQESLNK---------------IF-D----QLLLDR----------------------------------------------- T_guttata_ENSTGUP00000006693 ----------------------LTNQCFGI-EEEVSKYQDYINE---------------LQ-DALPQKMFA-A----------------------------------------------- A_carolinensis_ENSACAP00000003243 ----------------------LRKLCFDI-EKEVSKYQDYVDK---------------LQ-ENLPHKMLA-A----------------------------------------------- R_norvegicus_ENSRNOP00000030127 ----------------------IGHSVATC-NSEARGAQESLAK---------------MF-D----QLLLDR----------------------------------------------- O_cuniculus_ENSOCUP00000010441 ----------------------LTNQCFDI-EEEVSKYQDYTN----------------LQ-ETL-QKMFA-A----------------------------------------------- E_caballus_ENSECAP00000018587 ----------------------LTNQCFDI-EEEVSKYQDYTSE---------------LQ-ETLPQKMFA-A----------------------------------------------- M_mulatta_ENSMMUP00000010063 ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------LQ-ETLPQKMFA-A----------------------------------------------- P_troglodytes_ENSPTRP00000008798 ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------LQ-ETLPQKMFT-A----------------------------------------------- P_pygmaeus_ENSPPYP00000005386 ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------LQ-ETLPQKMFT-A----------------------------------------------- H_sapiens_ENSP00000329967 ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------LQ-ETLPQKMFT-A----------------------------------------------- C_familiaris_ENSCAFP00000000505 ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------LQ-ETLPQKMFA-A----------------------------------------------- O_anatinus_ENSOANP00000008566 ----------------------VNSTVAAC-SSEAQGTQECLRE---------------VM-SFWGCSRCPGS----------------------------------------------- G_gallus_ENSGALP00000015982 ----------------------LTNQCFDI-EEEVSKYQDYINE---------------LQ-DALPQKMFA-A----------------------------------------------- M_musculus_ENSMUSP00000020316 ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------LQ-ETLPQKMLA-A----------------------------------------------- G_aculeatus_ENSGACP00000000485 ----------------------FSSFSTDL-LAEVEMNEHHLNK---------------AL-DRILCTLQSKQ----------------------------------------------- D_melanogaster_FBpp0080920 ----------------------LEKDVRDC-ERKLNGIRDELYH----------------VKSELKLDVDTKT----------------------------------------------- O_latipes_ENSORLP00000019746 ----------------------FGSLSTGL-LTDLEMDEMHYNK----------------IMDNILSTPPHQR----------------------------------------------- G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ----------------------LFKDVGSH-EDTLYDIRVRLVQ----------------IKEDLKEDI--------------------------------------------------- B_taurus_ENSBTAP00000023134 ----------------------LTNQCFDI-EEEVSKYQEYTNE---------------LQ-ETLPQKMFA-A----------------------------------------------- T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ----------------------LTKDVGAY-VDALYELREQLKQ----------------HREDLKEEIST------------------------------------------------- R_norvegicus_ENSRNOP00000009260 ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------LQ-ETLPQKMLA-A----------------------------------------------- C_intestinalis_ENSCINP00000011687 ----------------------CETRIMRL-SDRCQEQEESIRT----------LQRVYRDKLSLVESILKEN----------------------------------------------- D_rerio_ENSDARP00000087779 ----------------------HSSVHSSI-HSFICSFIHLIYL---------------FI-HSFIHLLIHSF----------------------------------------------- O_anatinus_ENSOANP00000015719 ----------------------LTNQCFDI-EEEVSKYQDYTNE---------------LQ-ETLPQKMFA-A----------------------------------------------- P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 MGVGFYDGLLILLLHVLSEVCGDVAMVREFAASELWGIVWHLFAM--VLHMTTQEPMLEGETSGAGQHAPEPDWDLISPQGTPFFLSLTLFVFTCEPHQCLLQMAQPNGLIMAVLNKLLD M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ---------------------------PSSLPIKTSGVAGGIARL---NSSKKCHTGSNGLTAAYIPSFLKKE----------------------------------------------- O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ----------------------FGRRVIHLNEKDVTEQRKNLTK---------------------------------------------------------------------------- M_domestica_ENSMODP00000019211 -GCFLFQ--------------GGAEIVQDVANSELWTILWHRFFM--TLRLSEEVPTSEDKMSLPSQSVPEPEWTLISPQGITALLNVALAVFTQEPHLCLPYLIQHNSILMSTLKHLLS O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ---------------------------GSSLSGKSSGSISEISRM---NSVVSGYLGSSRLTSGYFPSFLKKE----------------------------------------------- A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ----------------------FDDDLEDILGSRIKSTKKSNAEFKLEDLFGTVSFGKDTKISKYPNTVPFAK----------------------------------------------- M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ---------------------------SSGVSGKSSGTVSVISKI---NSVGSGSASSRGLTGNYIPSFLKKE----------------------------------------------- A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ---------------------------SSGLSGKSSGTVSVISKI---TSVGSSSTSSSGLAGNYIPSFLKKE----------------------------------------------- C_familiaris_ENSCAFP00000003279 ---------------------------SSGLSGKSSGTVSCVTSFCFCESVGSGSTSSSGLTGNYIPSFLKKE----------------------------------------------- 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ----------------------------------------------------------------MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL M_mulatta_ENSMMUP00000010949 ----------------------------------------------------------------MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL P_troglodytes_ENSPTRP00000034602 ----------------------------------------------------------------MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL C_familiaris_ENSCAFP00000008270 ----------------------------------------------------------------MNASR----LSHSGQL-LAQPSPAPSSLP-----EAI--KKSEELVAEAHTLCTQL M_musculus_ENSMUSP00000033939 ----------------------------------------------------------------MNVSR----LSHPGQL-MSQPSSACDSLP-----ESD--KKSEELVAEAHALCSRL R_norvegicus_ENSRNOP00000025851 ----------------------------------------------------------------MNVSR----LSHPGHL-MSQPSSACDSLP-----DSD--KKSEELVAEAHALCSRL B_taurus_ENSBTAP00000049055 ----------------------------------------------------------------MNASR----LSHPCQL-MSQPCTAPDSLP-----EAA--EKSEDLVAEAHTLCTQL P_pygmaeus_ENSPPYP00000020804 ----------------------------------------------------------------MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKSEELVAEAHNLCTLL O_anatinus_ENSOANP00000001111 ----------------------------------------------------------------MNTSR----LSNSNQL-LSQPPAVPCSLP-----EPI--RKSEDLVVEAQNLCTQL E_caballus_ENSECAP00000003662 ----------------------------------------------------------------MNASR----LSHSGQL-VSQPSTTPDSLP-----ESA--KKSEELVAEAHSLCTQL M_domestica_ENSMODP00000012792 ----------------------------------------------------------------MNASR----LSNPSQL-LSQPPTAPYSLP-----DSI--KKSEELVTETQSLCTQL G_gallus_ENSGALP00000005924 ----------------------------------------------------------------MNMSR----LNSPGQL-LLQVPSGTYALS-----ESV--RKSEELLLESQKLCSQL G_gorilla_ENSGGOP00000006628 ----------------------------------------------------------------MNASR----LSQPGQL-MSQPSTASNSLP-----EPA--KKXXXXXXXXXXXXXXX A_carolinensis_ENSACAP00000012680 ----------------------------------------------------------------MNPSR----LSSPGQL-PLQVTAPQSNAG-----DAG--IKSEELLTESQTLCSQL O_cuniculus_ENSOCUP00000006175 ----------------------------------------------------------------XXXXX----XXXXXXX-XXXXXXXXXXXX-----XXX--XXXEDLVAEAHSLCTQL X_tropicalis_ENSXETP00000036619 ----------------------------------------------------------------LGTSR----MPGPSQL-LSQPPALSASLA----QEYV--KKSEDLLSESLKLCRQM O_latipes_ENSORLP00000003067 ----------------------------------------------------------------LRTPSSVPPLLTPRDS-LQQIINPSSD------------KSDESLLEESRTFESRL T_nigroviridis_ENSTNIP00000019003 ----------------------------------------------------------------------VSPLLTPTHS-LQQLALITFNNG------FGCVCSDESLVEESRTFESRL G_aculeatus_ENSGACP00000005440 ----------------------------------------------------------------LPTPSSVPPLLTPRHS-LQQF--------------------DESLVEESRTFEGRL T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 ----------------------------------------------------------------TASTPAATWVPQS-SS-EYAPHPLSSMAT----PGDG--ENFVDVIEENLNYLDRF T_rubripes_ENSTRUP00000022821 ----------------------------------------------------------------STMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQL R_norvegicus_ENSRNOP00000034134 ----------------------------------------------------------------TVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHL P_troglodytes_ENSPTRP00000055512 ----------------------------------------------------------------AVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHL H_sapiens_ENSP00000359424 ----------------------------------------------------------------AVTPQTSAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIEENLNCLGHL M_mulatta_ENSMMUP00000024306 ----------------------------------------------------------------AVTPQTSVWLPPT-SA--EHDHSLSCVVT----PQDG--DTSAQMIEENLNCLGHL D_rerio_ENSDARP00000013115 ----------------------------------------------------------------PSSL--STWNQTQAQC--SSRLPM-SLQV----PHEG--DSVNHLLEENQRYLTQL C_familiaris_ENSCAFP00000014093 ----------------------------------------------------------------AVTPQASAWLPPN-SA--EREHPLSCVVT----PQDG--ETIVQMIEENLNCLGHL B_taurus_ENSBTAP00000009985 -----------------------------------------------------------------VTPQ----LPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHL M_musculus_ENSMUSP00000026217 ----------------------------------------------------------------TVTPPVSAWLPPT-LA--DREHPLTCVVT----PQDG--ETLAQMIEENLNCLGHL M_domestica_ENSMODP00000013213 ----------------------------------------------------------------AATSPPSAGLPSALTA--PMPRSLSCVLS----AQDG--ETFTQIVEENLNYLGCL T_guttata_ENSTGUP00000004836 ----------------------------------------------------------------TASSPAATWLPQS-SS---------------------------------------- O_latipes_ENSORLP00000016017 ----------------------------------------------------------------SNLLQVSQWSQSAQPV--SSPHPLVSLPG----PNDS--DAAPRLLQENQKYLSQL G_aculeatus_ENSGACP00000005520 ----------------------------------------------------------------SNLLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENERYLCQL P_pygmaeus_ENSPPYP00000002975 ----------------------------------------------------------------AVTPQASAWLPPT-SA--EHDHSLSCVVT----PQDG--ETSAQMIAENLNCLGHL X_tropicalis_ENSXETP00000038296 ----------------------------------------------------------------PITPRTSAWPDQS-SS-----QALFSMLT----TKDKSREILRHTIDKNSDYQKLL T_nigroviridis_ENSTNIP00000014802 ----------------------------------------------------------------STMLQVSQWSQSAQPV--SSPHPLTSLPG----PNDS--DAAPRLLQENQRYLSQL A_carolinensis_ENSACAP00000011973 ----------------------------------------------------------------EVTSSVPACLSQT-PS-GNVLQPLSSMET----SRNL--VPFAHLIEENLSYLHSF E_caballus_ENSECAP00000005937 ----------------------------------------------------------------AVTPQASAWLPPT-SA--EREHPLSCVVT----PQDG--ETLAQMIEENLNCLGHL G_aculeatus_ENSGACP00000008884 ----------------------------------------------------------------AYSRPEIVW-RLNTYA--NTKRPYTVHTG----ACGI--ETVSQLLDENQRYLSQL T_rubripes_ENSTRUP00000036336 ----------------------------------------------------------------A---TICVF-RLIPVL--RHSHSHNNHVT----G-----ESVHQLLEENENYLSQL O_anatinus_ENSOANP00000003934 ----------------------------------------------------------------AVPPPTPAWLPAS-AT-ETVPHPFSSLVT----PKDG--ENFTQMIEENLNYLGCF O_latipes_ENSORLP00000011761 ----------------------------------------------------------------RTTLQCRHNIPLIGKI--SSKR-----------------ETVGQLLNENQRYLSHL T_nigroviridis_ENSTNIP00000019642 ----------------------------------------------------------------P---NI---------------HSDGSEMTFFFFS-----MSVHQLLEENENYLSQL T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 ----------------------------------------------------------------XXXXXXXXXXXXX-XX--XXXXXXXXXXX----XXXX--ETSAQMIEENLNCLGHL T_guttata_ENSTGUP00000016868 ----------------------------------------------------------------TASSPAATWLPQS-SSGNAAPHPLSSLAA----PEDG--ENFADMIQENVNYLELF O_cuniculus_ENSOCUP00000011297 ----------------------------------------------------------------TVTPQASAWLPPT-SA--QREHPLSCVVT----PQDG--DTFAQMIEENLNCLGHL A_aegypti_AAEL003245-PA ----------------------------------------------------------------AAIIPDIDRIMGSSSG-----------------------TANGDLPGAPKFVVGGT A_gambiae_AGAP009166-PA ----------------------------------------------------------------IADIDDMVPVFASAKT-----------------------RSIASSNGTPKFLLGGP A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ----------------------------------------------------------------LELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKIDHY------ T_rubripes_ENSTRUP00000005087 ----------------------------------------------------------------------------------------------EPQQPGLEPTDKQHMVLRMHHLKEEM D_rerio_ENSDARP00000014302 ----------------------------------------------------------------------------------------------VKAEVVDGKKKEEHMILKMTRLKSEM D_rerio_ENSDARP00000074566 ----------------------------------------------------------------------------------------------VKAEVVDGKKKEEHMILKMTRLKSEM T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 ----------------------------------------------------------------T--QGAQASPPL------------------TAPYPSSVL---KDLVLHMQELHGEM P_pygmaeus_ENSPPYP00000000308 ----------------------------------------------------------------A--KGAQASPPP------------------IAPYPSPTR---KDLLLHMQELCEGM E_caballus_ENSECAP00000000587 ----------------------------------------------------------------A--KGAQASPPP------------------TAPYPSPAL---KDLVLHMQELYEEM H_sapiens_ENSP00000356087 ----------------------------------------------------------------A--KGAQASPPP------------------IAPYPSPTR---KDLLLHMQELCEGM X_tropicalis_ENSXETP00000015947 ----------------------------------------------------------------P--GGIKSAVNP------------------IYSSPNTLV----EMTLGMRKLKEDM A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 ----------------------------------------------------------------A--KGAQASPPP------------------IAPYPSPTP---KDLLLHMQELCEGM G_aculeatus_ENSGACP00000000783 ----------------------------------------------------------------S--SGMK---PQ------------------AYLSQNTLV----EMTLGMKKLKEEM C_familiaris_ENSCAFP00000035372 ----------------------------------------------------------------T--KEAQASPPP------------------TAPYPSPAL---TDLVLHMQELCEEM M_domestica_ENSMODP00000002458 ----------------------------------------------------------------M--KAAQDSSLP------------------LAAYSRSMP---KDLVLHIQELREEM T_nigroviridis_ENSTNIP00000005945 ----------------------------------------------------------------S--SGMK---SQ------------------AYLSQNTLV----EMTLGMKKLKEEM M_musculus_ENSMUSP00000054126 ----------------------------------------------------------------ASEQGAEVSPQP------------------MAPHPGPDP---KDLVFHMQELCNDM T_guttata_ENSTGUP00000006693 ----------------------------------------------------------------S--NGMKHTMNT------------------VYPSSNTLV----EMTLGMKKLKEEM A_carolinensis_ENSACAP00000003243 ----------------------------------------------------------------S--GGIKHAVNP------------------VYPSSNTLV----EMTLGMKKLKEEM R_norvegicus_ENSRNOP00000030127 ----------------------------------------------------------------ASKQGAEVSPQP------------------MATHPGPDP---KDLVFHMQELCNDM O_cuniculus_ENSOCUP00000010441 -------------------------------------------------------------------SGIKHTMT--------------------------------------------- E_caballus_ENSECAP00000018587 ----------------------------------------------------------------S--SGMKHAMTP------------------VYPCSNTLV----EMTLGMKKLKEEM M_mulatta_ENSMMUP00000010063 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM P_troglodytes_ENSPTRP00000008798 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM P_pygmaeus_ENSPPYP00000005386 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM H_sapiens_ENSP00000329967 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPSSNTLV----EMTLGMKKLKEEM C_familiaris_ENSCAFP00000000505 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPCSNTLV----EMTLGMKKLKEEM O_anatinus_ENSOANP00000008566 ----------------------------------------------------------------T--EGKAARPPR------------------PSPLFKYCY---QENSMDMRELQEEM G_gallus_ENSGALP00000015982 ----------------------------------------------------------------S--TGMKHTMNT------------------VYPSSNTLV----EMTLGMKKLKEEM M_musculus_ENSMUSP00000020316 ----------------------------------------------------------------S--GGVKHAMAP------------------IYPSSNTLV----EMTLGMKKLKEEM G_aculeatus_ENSGACP00000000485 ----------------------------------------------------------------------------------------------TGQQPEI----KDQMVSRMHHLKEEM D_melanogaster_FBpp0080920 -------------------------------------------------------------------------------------------------INNNNQLAKIEERNRLRVMQQQQ O_latipes_ENSORLP00000019746 ----------------------------------------------------------------------------------------------GEQQQGITPSEKDQMVSRMHHLREEM G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 ----------------------------------------------------------------S--SGIKHTMTP------------------IYPCSNTLV----EMTLGMKKLKEEM T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 ----------------------------------------------------------------S--SGIKHTVAP------------------IYPSSNTLV----EMTLGMKKLKEEM C_intestinalis_ENSCINP00000011687 ----------------------------------------------------------------AKPLSAASLPGPNLNVVQPSIAVPSSWPNSIDNPRSSRQRQLKQLRQGLIEAKNSL D_rerio_ENSDARP00000087779 ----------------------------------------------------------------A--SGII---NK---------------------SQNRMLYFMNMMIFAMKKLKEEM O_anatinus_ENSOANP00000015719 ----------------------------------------------------------------S--SGIKHTMNP------------------IYPSSNTLV----EMTLGMKKLKEEM P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 PDFLEQL-HEDGDLELVTTTVLQVCQVFCFAFAMDMDPEILEQILTNMKGSEIPAQLLQVCIHHLPCTKTELPLSLLCRLVLSDEEIIEQVVGA-ATSQDAIDFLSSIFLSDQVHLLADL M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ----------------------------------------------------------------VGSAGQRVHLAPIIDPSSLDPSSAYTSLKSVGPHIGRTSFNIPVKST--------- O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 PIFLQQLGQTQHGSELLPAVVLPVCQLLCFPFAMDVDVDVLLNILADLRDSEVPAHLLQVCCRYLLLPQAELPVSLLARLALTDSTTLNQFVASVAASPNTITFLSAALLGDQPLLTSDI O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ----------------------------------------------------------------VGSAGQRVHLAPI-----SDPPPGYASLKSVRPHHNRPLFHTQPRST--------- A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA -----------------------------------------------------------------GAMKKGDELTDIFDN--SDAKPSHSSANIVPRRKNQQVFVSNGSFAAGNEFNGVN M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ----------------------------------------------------------------IGSAMQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ----------------------------------------------------------------ISSALQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- C_familiaris_ENSCAFP00000003279 ----------------------------------------------------------------VGSAMQRVHLAPI-----PDPSPGYSSLKAVRPHPGRPFFHTQPRST--------- 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000339151 ENAIQDTVRE-------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000010949 ENAIQDTVRE-------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000034602 ENAIQDTVRE-------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000008270 ENAMQDTIKE-------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000033939 ESALQDTVKE-------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000025851 ESALQDTVKQ-------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000049055 ENALQDTMKE-------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000020804 ENAIQDTVRE-------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000001111 ENAMQDTMKE-------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000003662 ENAIQDTMKD-------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000012792 QSMMEDAMKK-------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000005924 ENVMHDTMKD-------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000006628 XXXXXXXXXX-------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012680 ENVMLDTMKD-------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000006175 ESAMQDTVKE-------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000036619 ETSMMGFMKE-------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003067 QSLLHTTIQE-------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019003 QSLLHDTIQE-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005440 QSLLHDTIQD-------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000041917 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005196 SSMLQEAREE-------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000022821 TSLMQEAADE-------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000034134 STIIREANED-------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000055512 STIIHEANEE-------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000359424 STIIHEANEE-------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000024306 STIIHEANEE-------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000013115 TSLLQETTEE-------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000014093 STIIHEANEE-------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000009985 STIIHEANEK-------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000026217 STIIREANED-------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000013213 STVIREATEE-------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000004836 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016017 TSLMQEAADD-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000005520 TSLMQEATDE-------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000002975 STIIHEANEE-------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000038296 SSLILQTQTT-------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000014802 TSLMQEGCGR-------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000011973 STVIQEATHG-------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000005937 GTIIREANEE-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000008884 TSLVQDATQE-------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000036336 TSLLQETTRD-------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000003934 STIIREAKEE-------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000011761 TSLMQDAAQS-------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019642 TSMLQETTKE-------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005662 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000008804 STIIHEANEE-------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000016868 SSILQEVRQE-------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000011297 STIIREANEE-------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL003245-PA VTTLQNSLGG-------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009166-PA MTPLPSTVTN-------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL010548-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0082690 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005087 EILVRELKCN-------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000014302 EAVAWELQKN-------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000074566 EAVAWELQKN-------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000010090 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000046540 KVLASDLQDN-------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000000308 KLLASDLLDN-------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000000587 KLLAFDLQDN-------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000356087 KLLASDLLDN-------------------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000015947 EGVVKELEEN-------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012863 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000038190 KLLASDLLDN-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000783 DEVSKELAEN-------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000035372 KLLAFDLQDN-------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002458 KLLAFDLQHN-------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000005945 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000054126 KLLAFDLQDN-------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006693 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000003243 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000030127 KLLAFDLQDN-------------------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000010441 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018587 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000010063 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000008798 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000005386 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000329967 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000000505 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000008566 KSVTFDLQHN-------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000015982 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000020316 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000000485 EMLVRELQCN-------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0080920 QEVMAVMRTN-------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000019746 ELLVRELQCN-------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000021757 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005359-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000023134 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000001142 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009565-PA ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000009260 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000011687 NEVRCEVQTG-------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000087779 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000015719 EGVVKELAEN-------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000021585 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000005140 ------------------------------------------------------------------------------------------------------------------------ C_elegans_T25E12.4a ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000366488 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000035898 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002909 LTLLTHIARA-SPSHLPFLEKLLSGSTSQ--ALSHLLGHSECLVRARTCSLVGNLLRHGQEFPHILQGQVGLLKSLLERLSDEDRHVRRSASFAVGNAAYQAGPFMQDLRKAVPCVVRLL M_mulatta_ENSMMUP00000026815 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000008611 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008832 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024909 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000023332 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0081883 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000019211 LSLLAHAARAWPPTHLPFLQDLLAGPDESYWPLRCLLGHPENPVRARAYGLLGHLLHQSTALRGALQSQAGLLSLLLAGLRDKDPAVRRSASFAVGNAAYQAGPLAPALVPAVPRVTQLL O_cuniculus_ENSOCUP00000002072 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013244 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000006427 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000018527 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000023457 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009974 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000002825 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL004761-PA ASFKLFPWED-------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000018568 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013710 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018062 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000309591 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013350 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000032222 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000884 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000025345 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019558 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL007931-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000024262 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000013822 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000020711 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000003279 ------------------------------------------------------------------------------------------------------------------------ 2170 2180 2190 2200 2210 2220 2230 2240 2250 2260 2270 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+========= H_sapiens_ENSP00000339151 -------------------------------------------------------------------------------QDQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ M_mulatta_ENSMMUP00000010949 -------------------------------------------------------------------------------QDQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ P_troglodytes_ENSPTRP00000034602 -------------------------------------------------------------------------------QDQ----SFTAL-DWSWLQMEEEE-HSCLEQA-S------ C_familiaris_ENSCAFP00000008270 -------------------------------------------------------------------------------QDQ----SLRSL-DWSWLQTEEEQ-NS-LEQA-S------ M_musculus_ENSMUSP00000033939 -------------------------------------------------------------------------------QDR----SFTTL-DWSWLQMEDEE-RCSLEQACD------ R_norvegicus_ENSRNOP00000025851 -------------------------------------------------------------------------------QDR----SFTTL-DWSWLQMEDEE-RCGLEQACD------ B_taurus_ENSBTAP00000049055 -------------------------------------------------------------------------------QDQ----SLRSL-DWSWLQSEEEE-QQSLERA-S------ P_pygmaeus_ENSPPYP00000020804 -------------------------------------------------------------------------------QHQ----SFTAL-DWSWLQTEEEE-HSCLEQA-S------ O_anatinus_ENSOANP00000001111 -------------------------------------------------------------------------------QDR----SFMAL-DWSWLQIDDEE-RNSLEQTQI------ E_caballus_ENSECAP00000003662 -------------------------------------------------------------------------------QDQ----SLRSL-DWSWLQTEDNE-QHSLEQA-S------ M_domestica_ENSMODP00000012792 -------------------------------------------------------------------------------QDQ----SFMTL-DWSWLHSEDGE-DEGVEQTQI------ G_gallus_ENSGALP00000005924 -------------------------------------------------------------------------------QEQ----SFMAL-DWSWLQLHVEE-RSSPEQTHM------ G_gorilla_ENSGGOP00000006628 -------------------------------------------------------------------------------XXX----XXXAL-DWSWLQTEEEE-HSCLEQA-S------ A_carolinensis_ENSACAP00000012680 -------------------------------------------------------------------------------QEH----SFMAL-DWSWLKLRAEE-KENLEQT-Q------ O_cuniculus_ENSOCUP00000006175 -------------------------------------------------------------------------------QDQ----SFMTL-DWSWLQPEEEE-EQA------------ X_tropicalis_ENSXETP00000036619 -------------------------------------------------------------------------------QDS----SLMSL-DWSWLSQQEEA-SGTSPITTT------ O_latipes_ENSORLP00000003067 -------------------------------------------------------------------------------SES----SMEMLREWTWLSGEESDFRCSFSHKID------ T_nigroviridis_ENSTNIP00000019003 -------------------------------------------------------------------------------STS----SMEMLSEWTWLR--------------------- G_aculeatus_ENSGACP00000005440 -------------------------------------------------------------------------------SQS----SMEVLREWTWLHSSQN-----FSSDLS------ T_rubripes_ENSTRUP00000041917 ----------------------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000005196 -------------------------------------------------------------------------------QNN----SLTNF-DWSWL-K-------------------- T_rubripes_ENSTRUP00000022821 -------------------------------------------------------------------------------QSK----SIVDQ-DWSWTKYETLTDKLKKRNA-------- R_norvegicus_ENSRNOP00000034134 -------------------------------------------------------------------------------QSS----SMMSL-DWSWLAE-------------------- P_troglodytes_ENSPTRP00000055512 -------------------------------------------------------------------------------QGS----SMMNL-DWSWLTE-------------------- H_sapiens_ENSP00000359424 -------------------------------------------------------------------------------QGN----SMMNL-DWSWLTE-------------------- M_mulatta_ENSMMUP00000024306 -------------------------------------------------------------------------------QGN----SMMNL-DWSWLTE-------------------- D_rerio_ENSDARP00000013115 -------------------------------------------------------------------------------KSE----SIMAQ-DWSWTKYESLVAKSPRL---------- C_familiaris_ENSCAFP00000014093 -------------------------------------------------------------------------------QGS----RMMNL-DWSWLTE-------------------- B_taurus_ENSBTAP00000009985 -------------------------------------------------------------------------------QGN----NMMSL-DWSWLTE-------------------- M_musculus_ENSMUSP00000026217 -------------------------------------------------------------------------------QSS----SLMSL-DWSWLAE-------------------- M_domestica_ENSMODP00000013213 -------------------------------------------------------------------------------QGK----NLMSL-DWSWLK--------------------- T_guttata_ENSTGUP00000004836 ----------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000016017 -------------------------------------------------------------------------------QAK----SIVDQ-DWSWTKYESLSTKLKKQNA-------- G_aculeatus_ENSGACP00000005520 -------------------------------------------------------------------------------QTK----SIVEQ-DWSWTKYETLTTKLKKRNP-------- P_pygmaeus_ENSPPYP00000002975 -------------------------------------------------------------------------------QGS----SMMNL-DWSWLTE-------------------- X_tropicalis_ENSXETP00000038296 ------------------------------------------------------------------------------MEQN----SLMSL-DFSWLNK-------------------- T_nigroviridis_ENSTNIP00000014802 -------------------------------------------------------------------------------TVQKGVSSFKDQ-DWSWTKYETLSTKLKKR---------- A_carolinensis_ENSACAP00000011973 -------------------------------------------------------------------------------QSS----SLKSL-DWSWL---------------------- E_caballus_ENSECAP00000005937 -------------------------------------------------------------------------------QGS----RMMNL-DWSWLTE-------------------- G_aculeatus_ENSGACP00000008884 -------------------------------------------------------------------------------MEH----SIMDQ-DWGWTKYGAAKAKPNNL---------- T_rubripes_ENSTRUP00000036336 -------------------------------------------------------------------------------PEY----SIMEQ-DWSWTQC-------------------- O_anatinus_ENSOANP00000003934 -------------------------------------------------------------------------------QGN----SMMSL-DWSWLNQ-------------------- O_latipes_ENSORLP00000011761 -------------------------------------------------------------------------------MEH----SVMDQ-DWSWTQSGAVKVQSQKP---------- T_nigroviridis_ENSTNIP00000019642 -------------------------------------------------------------------------------TEH----TVVEQ-DWSWTQY-------------------- T_guttata_ENSTGUP00000005662 ----------------------------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000008804 -------------------------------------------------------------------------------QGS----SMM------------------------------ T_guttata_ENSTGUP00000016868 -------------------------------------------------------------------------------QNS----MMVS----------------------------- O_cuniculus_ENSOCUP00000011297 -------------------------------------------------------------------------------QGN----SMMNL-DWSWLTG-------------------- A_aegypti_AAEL003245-PA ------------------------------------------------------------------------------EPISKSLLCYGEGPDVESLLTANQSLIMTYGSRIDSAKDVE A_gambiae_AGAP009166-PA ------------------------------------------------------------------------------GSIEGHHR-EEEGPNVDELIAANETLIMT------------ A_aegypti_AAEL010548-PA ----------------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0082690 ----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000005087 ------------------------------------------------------------------------------NSIIERHRLMTCPPHL------------------------- D_rerio_ENSDARP00000014302 ------------------------------------------------------------------------------NNMIESLSVVTPTMPVEKKNPQTNRP--------------- D_rerio_ENSDARP00000074566 ------------------------------------------------------------------------------NNMIESLSVVTPTMPVEKKNPQTNRP--------------- T_nigroviridis_ENSTNIP00000010090 ----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000046540 ------------------------------------------------------------------------------NRIIEGLSRIPLAPDI------------------------- P_pygmaeus_ENSPPYP00000000308 ------------------------------------------------------------------------------NRIIERLNTVPAPPDV------------------------- E_caballus_ENSECAP00000000587 ------------------------------------------------------------------------------NRIIEGLSRVPSTPGV------------------------- H_sapiens_ENSP00000356087 ------------------------------------------------------------------------------NRIIERLNRVPAPPDV------------------------- X_tropicalis_ENSXETP00000015947 ------------------------------------------------------------------------------NHILERFGALTIDGGFRNVD----CI--------------- A_carolinensis_ENSACAP00000012863 ----------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000038190 ------------------------------------------------------------------------------NRIIERLNRVPAAPDV------------------------- G_aculeatus_ENSGACP00000000783 ------------------------------------------------------------------------------NHFLERFGSLTLDGGLR------------------------ C_familiaris_ENSCAFP00000035372 ------------------------------------------------------------------------------NRIIEGLSRPPSAPDS------------------------- M_domestica_ENSMODP00000002458 ------------------------------------------------------------------------------NQIIERLSGVPAAPRS------------------------- T_nigroviridis_ENSTNIP00000005945 ------------------------------------------------------------------------------NHFLERFGTLTLDGGLR------------------------ M_musculus_ENSMUSP00000054126 ------------------------------------------------------------------------------NRLIERLHRVPSAPDV------------------------- T_guttata_ENSTGUP00000006693 ------------------------------------------------------------------------------NHILERFGALTMDGGLRNVD----CM--------------- A_carolinensis_ENSACAP00000003243 ------------------------------------------------------------------------------NHLLERFGALTMDGGPRNVD----CI--------------- R_norvegicus_ENSRNOP00000030127 ------------------------------------------------------------------------------NRLIERLHRVPPTPEV------------------------- O_cuniculus_ENSOCUP00000010441 ----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000018587 ------------------------------------------------------------------------------NHILERFGALTMDGGLRNVD----CL--------------- M_mulatta_ENSMMUP00000010063 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- P_troglodytes_ENSPTRP00000008798 ------------------------------------------------------------------------------NHILERFGSLTVDGGLRNVD----CL--------------- P_pygmaeus_ENSPPYP00000005386 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- H_sapiens_ENSP00000329967 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- C_familiaris_ENSCAFP00000000505 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- O_anatinus_ENSOANP00000008566 ------------------------------------------------------------------------------NSIIESLGRVPPFPFF------------------------- G_gallus_ENSGALP00000015982 ------------------------------------------------------------------------------NHILERFGALTADGGLRNVD----CI--------------- M_musculus_ENSMUSP00000020316 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- G_aculeatus_ENSGACP00000000485 ------------------------------------------------------------------------------NSIIESLGTVSPAEALEPNLARPSTL--------------- D_melanogaster_FBpp0080920 ------------------------------------------------------------------------------SDIISLLSKLGITNGSLESS--------------------- O_latipes_ENSORLP00000019746 ------------------------------------------------------------------------------NTIIERLCSLGVVDSAAAREASPARP--------------- G_gallus_ENSGALP00000021757 ----------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL005359-PA ----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000023134 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- T_guttata_ENSTGUP00000001142 ----------------------------------------------------------------------------------------------------------------------- A_gambiae_AGAP009565-PA ----------------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000009260 ------------------------------------------------------------------------------NHILERFGSLTMDGGLRNVD----CL--------------- C_intestinalis_ENSCINP00000011687 ------------------------------------------------------------------------------SEILKKLSSLTANRNCASPETPSRPCVPMRTND-------- D_rerio_ENSDARP00000087779 ------------------------------------------------------------------------------NLFLERFGSLTVDGGMRTVE----RM--------------- O_anatinus_ENSOANP00000015719 ------------------------------------------------------------------------------NHILERFGALTMDGGLRNVD----CL--------------- P_pygmaeus_ENSPPYP00000021585 ----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000005140 ----------------------------------------------------------------------------------------------------------------------- C_elegans_T25E12.4a ----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000366488 ----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000035898 ----------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000002909 GDPQAKTRCNAASALGNLGWQSVELGDSLIQNKAPNILLDVACHDSQPAVQKAALIALRSMSHQPRIRQVLVSLRACEKLEALTLDQ--FQNSAYSHPWPSSTQHCKKLIQLLQPSQSA M_mulatta_ENSMMUP00000026815 ----------------------------------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000008611 --------------------------------------------------------------------------------------------SALLPHPPPVQPVHGRTDWSLKYGAHR O_latipes_ENSORLP00000008832 ----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000024909 ----------------------------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000023332 ----------------------------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0081883 ----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000019211 GDPQTGTRRNAASALGNLGPEG--LGEELLRCQVPHRLLETACGDPQPTVREAALIALRSLRQEPSIHQVLVSLDASEKLASLSSASPLPPHSSSGSPRPSSARHCKKLIHLLRPAHST O_cuniculus_ENSOCUP00000002072 ----------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000013244 ----------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000006427 ----------------------------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000018527 ----------------------------------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000023457 --------------------------------------------------------------------------------------------PGLLPRPPAAQPVHGRTDWVSKYASRR A_carolinensis_ENSACAP00000009974 ----------------------------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000002825 ----------------------------------------------------------------------------------------------------------------------- A_aegypti_AAEL004761-PA ------------------------------------------------------------------------------APRNVPDKKQWVPDSGVLTYVGPSGDGKGRPDWAAKYLSK- M_mulatta_ENSMMUP00000018568 ----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000013710 ----------------------------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000018062 ----------------------------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000309591 ----------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013350 ----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000032222 ----------------------------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000000884 ----------------------------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000025345 ----------------------------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000019558 --------------------------------------------------------------------------------------------PGLMPRPPAAQPVHGRTDWAAKYASRR A_aegypti_AAEL007931-PA ----------------------------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000024262 ----------------------------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000013822 ----------------------------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000020711 --------------------------------------------------------------------------------------------PGLLPRPPAAQPVHGRTDWIAKYASRR C_familiaris_ENSCAFP00000003279 --------------------------------------------------------------------------------------------PGLMPRPPAAQPVHGGTDWASKYASRR