10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 --------------------------------------------------------------------------------------MAATVEGPE-----LEAAAAAGDASEDSDAGSRA M_mulatta_ENSMMUP00000021972 --------------------------------------------------------------------------------------MAAAVEGPE-----LEAAAAAGDASEDADAGSRV P_pygmaeus_ENSPPYP00000003356 --------------------------------------------------------------------------------------MAATVEGPE-----LEAAAAAGDASEDSDAGSRA P_troglodytes_ENSPTRP00000005532 --------------------------------------------------------------------------------------MAATVEGPE-----LEAAAAAGDASGDSDAGSRA B_taurus_ENSBTAP00000026157 --------------------------------------------------------------------------------------MAAMEAGPVPA--TLAQEDAARDASEAAGAGPEA C_familiaris_ENSCAFP00000013991 --------------------------------------------------------------------------------------MAAEAEGLEPQ--AAATEDAAGDATEAADA---E M_musculus_ENSMUSP00000026580 --------------------------------------------------------------------------------------MAAVLEGQEPEETAAAAEDAATSTLEAVDAGPGA G_gorilla_ENSGGOP00000010514 --------------------------------------------------------------------------------------MAATVEGPE-----LEAAAAAGDASEDSDAGSRA R_norvegicus_ENSRNOP00000025291 --------------------------------------------------------------------------------------MAAVLEGPKPEETAAAAEDAARPTVEAVASRPGV G_gallus_ENSGALP00000022986 ---------------------------------------------------------------------------------------------LAPLDKMQKMAELLKLGDEHGEGDPGA T_guttata_ENSTGUP00000010130 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015049 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017044 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007286 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000007907 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA -------------------------------------------NDTNTAFLRAARAGDLQKLIEYLETGQVTDINTCNTNGLNALHLAAKDGHYDIVNELLKRGALVDNATKKGNTALHI T_guttata_ENSTGUP00000005529 ------------------------------------------KADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNALHLASKEGHVKMVVELLHKEIVLETTTKKGNTALHI A_aegypti_AAEL013466-PA -----------------------------------------MYNDTNTAFLRAARAGDLQKLIEYLETGQVTDINTCNANGLNALHLAAKDGHFEIVQELLKRGANVDNATKKGNTALHI O_latipes_ENSORLP00000008143 ------------------------------SSVLPRGSHSAARADAGNSFLRAARSGNLDKALEHIKNG--IDINTANQNGLNALHLASKEGHVKMVLELLHNGIVLETTTKKGNTALHI E_caballus_ENSECAP00000009629 -------------------------------------------SDANASYLRAARAGHLEKALDYIKNG--VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHI P_pygmaeus_ENSPPYP00000020798 MPCSVG----------------------------------FRKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHI A_carolinensis_ENSACAP00000001474 --------------------------------------------DTNASYLRAARAGNLEKALDYLKNG--VDINICNQNGLNALHLASKEGHVEVVSELIQRGANVDAATKKGNTALHI D_rerio_ENSDARP00000077097 ----------------------------------------VSQADAATSFLRAARSGNLEKALDHIKNG--IDINTANQNGLNGLHLASKEGHVKMVLELLHHGIVLETTTKKGNTALHI G_gorilla_ENSGGOP00000011462 MPYSVG----------------------------------FREADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALXX D_melanogaster_FBpp0088239 --------MTLGDVRVENKIQTRSETCAINGMALDNKNGIIKQNDATISFLRAARSGDIKKVMDFLDCGEISDINSCNANGLNALHLAAKDGYVDICCELLRRGIKIDNATKKGNTALHI M_mulatta_ENSMMUP00000032129 AMAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNG--VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHI 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 LPFL----GGNRL-----SLDLYPGGCQQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC------------------------------------------------ M_mulatta_ENSMMUP00000021972 RPFL----GGNRL-----SLDLYPGGCQRLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC------------------------------------------------ P_pygmaeus_ENSPPYP00000003356 LPFL----GGNRL-----SLDLYPRGCQQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC------------------------------------------------ P_troglodytes_ENSPTRP00000005532 LPFL----GGNRL-----SLDLYPGGCQQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC------------------------------------------------ B_taurus_ENSBTAP00000026157 PLLP----AGNRL-----SLHLHPGGCRRLLRLCAQQ-APQLLEVDFLQLSGHEDPQLLEAALARLPWSLPR------------------------------------------------ C_familiaris_ENSCAFP00000013991 LRLL----VGNRL-----SLDLYPGGCHRLLHLCAQR-PPQLGEVEFLQLSGHEDPQLLEATLTQVPRNLQR------------------------------------------------ M_musculus_ENSMUSP00000026580 PFLP----AGNQL-----NLDLRPGGCHRLQYLCSQQ-PPQLLQVEFLRLSTHEDPQLLDDTLAKVPWSLLR------------------------------------------------ G_gorilla_ENSGGOP00000010514 LPFL----GGNRL-----SLDLYPGGCQQLLHLCVQQ-PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC------------------------------------------------ R_norvegicus_ENSRNOP00000025291 PILL----AGNQL-----NLDLRPGGCRRLQYLCSQQ-HTQLLQVEFLRLSTHEDPRLLDDTLAKVPWSLLR------------------------------------------------ G_gallus_ENSGALP00000022986 PSLSGSCLADNRL-----TLDVYPDGCRRLLRLFEGQ-QAEVVQVELLRLSSND--RLLDATLSILP-HLKR------------------------------------------------ T_guttata_ENSTGUP00000010130 --------ADNRL-----NLDVYPDGCRRFLQLFKEQ-HREVVQVEFLRLSSND--CLLDTTLGSLP-HLKH------------------------------------------------ A_carolinensis_ENSACAP00000015049 --------AGNRL-----NLDVYAEGCLSFLRLFETR-SEEVEQVEFLRLSCNE--EHIASILSIIP-ALKG------------------------------------------------ T_rubripes_ENSTRUP00000017044 -------LADTRL-----TLDVYKGGAAALPLLWASI-PEQLMGVQYLTVGSED-KAGLDDALDVIP-NLTD------------------------------------------------ G_aculeatus_ENSGACP00000007286 -----------RL-----TLDVYRGGAAALPLLWGSV-PGRLRGLRYLRLGSED-KPGLDEALHVLP-QLTE------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 -------LADTRL-----TLDVYKGGAAALPLLWASI-PEQLTGVQYLTLGSDD-KEGLDDALDLVP-HLTD------------------------------------------------ O_latipes_ENSORLP00000007907 -----------RL-----TLDVYPGGAGALPLLWGSI-PAELRGIQYLRLGSED-RSGLDGALNVLS-NLTE------------------------------------------------ M_domestica_ENSMODP00000018737 --LL----ASNKL-----NLELYPGGCGLLLRLLGQETAANLQRVQFLRLNCHE--EQVEAALALLP-RLEH------------------------------------------------ O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA ASLAGQKEIIQLLLQYNASVNVQS--QNGFTPLYMAAQENHDECVNYLLAKGANPALATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAAKLLLENEHNPDVS T_guttata_ENSTGUP00000005529 AALAGQQDVVRELVNYGANVNAQS--QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNADVL A_aegypti_AAEL013466-PA ASLAGQKEIIQLLLQYNASVNVQS--QNGFTPLYMAAQENHDECVNLLLAKGANPALATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLENEHNPDVS O_latipes_ENSORLP00000008143 AALAGQEQVVTELVNYGTNVNAQSQRQKGFTPLYMAAQENHLEVVKFLLENGANQSIPTEDGFTPLAVALQQGHENVVALLISYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL E_caballus_ENSECAP00000009629 ASLAGQAEVVKVLVTNGANVNAQS--QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVE P_pygmaeus_ENSPPYP00000020798 AALAGQDEVVRELVNYGANVNAQS--QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL-QGHENVVAH--------------------NDDTRTAAVLLQ-DPNPDVL A_carolinensis_ENSACAP00000001474 ASLAGQTEVVKVLVTNGANVNAQS--QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDHNADVE D_rerio_ENSDARP00000077097 AALAGQEQVVTELVNYGANVNAQSQQQKGFTPLYMAAQENHLEVVKFLLDNGANQTIPTEDGFTPLAVALQQGHENVVALLINHGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL G_gorilla_ENSGGOP00000011462 XXXXXXXXXXXXXXXXXXXXXXXX--XKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL D_melanogaster_FBpp0088239 ASLAGQHDVINQLILYNANVNVQS--LNGFTPLYMAAQENHDNCCRTLLANGANPSLSTEDGFTPLAVAMQQGHDKIVAVLLENDVRGKVRLPALHIAAKKNDVNAAKLLLQHDPNADIV M_mulatta_ENSMMUP00000032129 AALAGQDEVVRELVNYGANVNAQS--QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVL 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ----------------------------------------------------LRSLVLK----GGQRRDTL---------------------GACLRGALTNLPAGLSGLAHLAHL---- M_mulatta_ENSMMUP00000021972 ----------------------------------------------------LRSLVLK----GGQRRDTL---------------------GACLRGALTTLPAGLSGLAHLAHL---- P_pygmaeus_ENSPPYP00000003356 ----------------------------------------------------LRSLVLK----GGQRRDTL---------------------GACLRGALTNLPAGLSGLAHLAHL---- P_troglodytes_ENSPTRP00000005532 ----------------------------------------------------LRSLVLK----GGQRRDTL---------------------GACLRGALTNLPAGLSGLAHLAHL---- B_taurus_ENSBTAP00000026157 ----------------------------------------------------LRSLVLK----GGQRREAL---------------------GACLRGSLATLPASLSSLARLAHL---- C_familiaris_ENSCAFP00000013991 ----------------------------------------------------LRSLVLR----GGQHWDVL---------------------GACLRGSLTTLPAGLSGLARLAHL---- M_musculus_ENSMUSP00000026580 ----------------------------------------------------LRSLVLK----GGQSRGAL---------------------GACLHGTLTTLPAGLSDLACLAHL---- G_gorilla_ENSGGOP00000010514 ----------------------------------------------------LRSLVLK----GGQRRDTL---------------------GACLRGALTNLPAGLSGLAHLAHL---- R_norvegicus_ENSRNOP00000025291 ----------------------------------------------------LRSLVLK----GGQSRGAL---------------------GACLHGTLTTLPASMRDLACLAHL---- G_gallus_ENSGALP00000022986 ----------------------------------------------------LKSLVLR----GGHVRDEF---------------------GSCQHGSLTSLPPEVGTLRCLTHL---- T_guttata_ENSTGUP00000010130 ----------------------------------------------------LKSLVLK----GGLARDEF---------------------GSYQHGSLTSLPPDFGNLRCLTHL---- A_carolinensis_ENSACAP00000015049 ----------------------------------------------------LKSLVLK----GGHTRDEA---------------------GACQRGLLFSLPQELGELTQLAHL---- T_rubripes_ENSTRUP00000017044 ----------------------------------------------------LHTLTIR----GHRFYDAQ---------------------GDPLPGLLTTLPMSFSCLSQLVHL---- G_aculeatus_ENSGACP00000007286 ----------------------------------------------------LRSLAAR----GHRFNDPR---------------------GDPLPGLLTTLPSSVSHLSHLVHL---- T_nigroviridis_ENSTNIP00000019169 ----------------------------------------------------LRTLAIR----GHRFYDTQ---------------------GDPLPGLLTSLPASFSCLLQLVHL---- O_latipes_ENSORLP00000007907 ----------------------------------------------------LRSLAIR----GHRLYDSK---------------------GTPLPGLLTTLPSSVSSLTHLVHL---- M_domestica_ENSMODP00000018737 ----------------------------------------------------LRSLVLKVSWERGHLRDDG---------------------GSCLRGALTTLPPSLSALAHLVHL---- O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA SKSGFTPLHIAAHYGNVNVAQLLIEKGADVNFTAKHNITPLHVACKWGKLNMVKLLIANHGRIDSITRDGLTPLHCAARSGHDQVIEVLLEHGAEIISKTKNGLAPLHMAAQGEHVSAAR T_guttata_ENSTGUP00000005529 SKTGFTPLHIAAHYENLSVAQLLLNRGASVNFTPQNGITPLHIASRRGNIIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRIAEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR A_aegypti_AAEL013466-PA SKSGFTPLHIAAHYGNVNVAQLLIEKGADVNFTAKHNITPLHVACKWGKLNMVSMLIKNSARIDAVTRDGLTPLHCAARSGHDQVIDLLLEHNADIIAKTKNGLAPLHMAAQGEHVSAAK O_latipes_ENSORLP00000008143 SKTGFTPLHIAAHYENLNVAQLLLNRGANVNFTPKNGITPLHIASRRGNVIMVRLLLDRGAQIDAKTKDELTPLHCAARNGHFRIIEILLDNGAPIQAKTKNGLSPIHMAAQGDHMDCVK E_caballus_ENSECAP00000009629 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQ P_pygmaeus_ENSPPYP00000020798 -KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR A_carolinensis_ENSACAP00000001474 SKSGFTPLHIAAHYGNINVATLLLNRGAAVDFTARNDITPLHVASKRGNTNMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVRMLLDRGAPILSKTKNGLSPLHMATQGDHLNCVQ D_rerio_ENSDARP00000077097 SKTGFTPLHIAAHYENLNVAQLLLNRGADVNFTPKNGITPLHIASRRGNVIMVRLLLDRGAKIDAKTKDELTPLHCAARNGHVRIIEILLDQGAPIQAKTKNGLSPIHMAAQGDHLDCIR G_gorilla_ENSGGOP00000011462 SKXXXXXXXXXXXXXXXXXXXXXXXXXXSVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCXX D_melanogaster_FBpp0088239 SKSGFTPLHIAAHYGNVDIATLLLNNKADVNYVAKHNITPLHVACKWGKLSLCTLLLCRGAKIDAATRDGLTPLHCASRSGHVEVIKHLLQQNAPILTKTKNGLSALHMAAQGEHDEAAH M_mulatta_ENSMMUP00000032129 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVR 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ----------DLSFNSLETLP----------------------------------ACVLQMRGLGALLLSHN-CLSELPEA----------LGALPALTFL------------------- M_mulatta_ENSMMUP00000021972 ----------DLSFNSLETLP----------------------------------SCVLQMRGLGALLLSHN-CLSELPEA----------LGALPALTFL------------------- P_pygmaeus_ENSPPYP00000003356 ----------DLSFNSLETLP----------------------------------ACVLRMRGLGALLLSHN-CLSELPEA----------LGAIPALTFL------------------- P_troglodytes_ENSPTRP00000005532 ----------DLSFNSLETLP----------------------------------ACVLQMRGLGALLLSHN-CLSELPEA----------LGALPALTFL------------------- B_taurus_ENSBTAP00000026157 ----------DLSFNSLETLP----------------------------------ACVPQMCGLDALLLSRN-CLSELPAA----------LGALPALTFL------------------- C_familiaris_ENSCAFP00000013991 ----------DLSFNSLETLP----------------------------------ACIPQMRGLSTLLLSYN-HLSELPEA----------LGALPSLTFL------------------- M_musculus_ENSMUSP00000026580 ----------DLSFNRLETLP----------------------------------TCVPELHGLDALLLSHN-HLSELPEA----------LGALPALTFL------------------- G_gorilla_ENSGGOP00000010514 ----------DLSFNSLETLP----------------------------------ACVLQMRGLGALLLXXX-XXXXXXXX----------XXXXXXXXXX------------------- R_norvegicus_ENSRNOP00000025291 ----------DLSFNRLETLP----------------------------------TCVLELHSLDALLLSHN-CLSELPEA----------LGALPTLTFL------------------- G_gallus_ENSGALP00000022986 ----------DLSFNSLSTLP----------------------------------SCIPSLTSLRMLLVSHN-NLVALPEN----------FGSLSKLTFF------------------- T_guttata_ENSTGUP00000010130 ----------DLSFNRLSTLP----------------------------------SCILHLPSLRVLLVSHN-SLVTLPED----------FGSLSKLTFF------------------- A_carolinensis_ENSACAP00000015049 ----------DLSFNNFTALP----------------------------------PCVTKLLSLRSLLISHN-SLQELPED----------FGQLSELTFF------------------- T_rubripes_ENSTRUP00000017044 ----------DLSFNQLSCVP----------------------------------PCLLGLPTLSSLLLCQN-RISELPSD----------VGQLSSLTYL------------------- G_aculeatus_ENSGACP00000007286 ----------DLSFNQLTCLP----------------------------------PCLLGLPGLSSLLLSYN-HISELPPD----------IGQLSSLTYL------------------- T_nigroviridis_ENSTNIP00000019169 ----------DLSFNQLSCVP----------------------------------ACLLSLP-LSSLLLCQN-QISELPPD----------IGQLSSLTYL------------------- O_latipes_ENSORLP00000007907 ----------DLSFNQLSCLP----------------------------------PCLLSLPLLSSLLLCHN-FISALPPE----------ICQLSSLTYL------------------- M_domestica_ENSMODP00000018737 ----------DLSFNSLRVLP----------------------------------ACIPEMRALQALLLSHN-LLEGLPEA----------LGALQGLTFL------------------- O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA ILLMNKSPVDDITIDYLTALHVAAHCGHVKVAKLLLDRNADPNARALNGFTPLHIACKKNRIKVVELLLNHGATIGATTESGLTPLHVASFMGCMNIVIYLLQHDASPDIPTVRGETPLH T_guttata_ENSTGUP00000005529 LLLQYSAEIDDITLDHLTPLHVAAHCGHHRVAKLLVEKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVAAFMGHLPIVKTLLQRGASPNVSNVKVETPLH A_aegypti_AAEL013466-PA ILLVHKSPVDDITIDYLTALHVAAHCGHVKVAKLLLDRNADPNARALNGFTPLHIACKKNRIKVVELLLKHGATISATTESGLTPLHVASFMGCMNIVIYLLQHDASPDIPTVRGETPLH O_latipes_ENSORLP00000008143 QLLQYNAEIDDITLDHLTPLHVAAHCGHHRMAKVLLDKGAKPNSRALNGFTPLHIACKKNHLRVMDLLLKHSASIEAVTESGLTPLHVASFMGHLNIVKILLQKGASPSASNVKVETPLH E_caballus_ENSECAP00000009629 LLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH P_pygmaeus_ENSPPYP00000020798 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH A_carolinensis_ENSACAP00000001474 LLIEHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKTNPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALH D_rerio_ENSDARP00000077097 QLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNTRALNGFTPLHIACKKNHMRVMDLLLKHSASLEAVTESGLTPLHVSSFMGHLNIVKILMQKGASPNASNVKVETPLH G_gorilla_ENSGGOP00000011462 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVXXXXXXX D_melanogaster_FBpp0088239 LLLDNKAPVDEVTVDYLTALHVAAHCGHVKVAKLLLDYKANPNARALNGFTPLHIACKKNRIKMVELLIKHGANIGATTESGLTPLHVASFMGCINIVIYLLQHEASADLPTIRGETPLH M_mulatta_ENSMMUP00000032129 LLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021972 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003356 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005532 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026157 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000013991 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026580 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010514 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025291 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000022986 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010130 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015049 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017044 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007286 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000007907 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA LAARAKQTDIIRILLRNGAYVNAQAREDQTPLHVASRIGNMEIVMLLLQHGAKIDAVTKDNYTPLHIAAKEGQDEVAALLLDSEANVEAVTKKGFTPLHLAAKYGNLKCAELLLERGAQV T_guttata_ENSTGUP00000005529 MAARAGHTDVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENNANPNLATTAGHTPLHITAREGHMDTALALLEKGASQTCMTKKGFTPLHVAAKYGKVDVAELLLAHDAHL A_aegypti_AAEL013466-PA LAARAKQADIIRILLRNGAYVNAQAREDQTPLHVASRIGNVDIVMLLLQHGAKIDATTKDNYTPLHIAAKEGQDDVAAVLLDNKANMEAVTKKGFTPLHLAAKYGNLECAQLLLDRGAQV O_latipes_ENSORLP00000008143 MASRSGHFEVAEFLLQNAAPVDAKAKDDQTPLHCAARMGHKELVKLLLEHKANPNSTTTAGHSPLHIAAREGHVQTVRLLLDMEAQQTKMTKKGFTPLHVASKYGKVDVAELLLERGANP E_caballus_ENSECAP00000009629 MAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP P_pygmaeus_ENSPPYP00000020798 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLEQDAHP A_carolinensis_ENSACAP00000001474 MAARAGQSEVVRYLVQNGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVASVLLDHGASLCITTKKGFTPLHVAAKYGKIEVANLLLQKNASP D_rerio_ENSDARP00000077097 MASRAGHCEVAEFLLQNAAPVDAKAKDDQTPLHCASRMGHNEMVKLLLEHKANSNSTTTAGHTPLHIAAREGHTQTASILLDMNAQLTKMTKKGFTPLHVAAKYGKVDVAVLLLERGANP G_gorilla_ENSGGOP00000011462 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX D_melanogaster_FBpp0088239 LAARANQADIIRILLRS-AKVDAIAREGQTPLHVASRLGNINIIMLLLQHGAEINAQSNDKYSALHIAAKEGQENIVQVLLENGAENNAVTKKGFTPLHLACKYGKQNVVQILLQNGASI M_mulatta_ENSMMUP00000032129 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLEQDAHP 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 -TVTHNRLQTLPPA-----------------------------LGALSTLQRLDLSQNLLD----------------TLPPEIGGLG--------------------SLLELNL------ M_mulatta_ENSMMUP00000021972 -AVTHNRLQTLPPA-----------------------------LGAL-TLQRLDLSQNLLD----------------TLPPEIGGLG--------------------SLLELNL------ P_pygmaeus_ENSPPYP00000003356 -AVTHNRLQTLPPA-----------------------------LGALSTLQRLDLSQNLLD----------------TLPPEIGGLG--------------------SLLELNL------ P_troglodytes_ENSPTRP00000005532 -TVTHNRLQTLPPA-----------------------------LGALSTLQRLDLSQNLLD----------------TLPPEIGGLG--------------------SLLELNL------ B_taurus_ENSBTAP00000026157 -AVTHNRLRTLPPA-----------------------------LGALSSLQRLDLSGNLLE----------------ALPPEIGGLG--------------------SLAELNL------ C_familiaris_ENSCAFP00000013991 -SVTHNRLQTLPIA-----------------------------LGALSTLQRLDLSGNLLD----------------TLPPEIGGLS--------------------SLTELNL------ M_musculus_ENSMUSP00000026580 -TVTHNRLERLPLT-----------------------------LGSLSTLQRLDLSENLLD----------------TIPSEIGNLR--------------------SLSELNL------ G_gorilla_ENSGGOP00000010514 -XXXXXXXXXXXXX-----------------------------XXXXXXXXXXXXXXXXXX----------------XXXXXXXXXX--------------------XXXXXXX------ R_norvegicus_ENSRNOP00000025291 -TVTHNLLERLPPT-----------------------------LGSLSTLQRLDLSENLLD----------------TIPSEIGDLS--------------------SLRELNL------ G_gallus_ENSGALP00000022986 -SAMKNQLKDLPQS-----------------------------IGELAALEDLDLSENVLE----------------LLPEEIGNLH--------------------SCTELDL------ T_guttata_ENSTGUP00000010130 -SAMKNQLKDLPQS-----------------------------IGELSLLQDLDLSENALE----------------LLPEEVGNLH--------------------NCTELDL------ A_carolinensis_ENSACAP00000015049 -SAMKNQLRDLPQG-----------------------------IGELVALQTLDLSENALK----------------SLPEEIGNLH--------------------SCMELDL------ T_rubripes_ENSTRUP00000017044 -SLLGNKLITLPPS-----------------------------LGQLSGLRTLDVSLNLLQ----------------RLPDEIGSLG--------------------GLVKLEL------ G_aculeatus_ENSGACP00000007286 -CLLGNELVSLPRG-----------------------------VGRLKALQRLDVSHNLLE----------------RLPDEIGSLE--------------------GLEKLEL------ T_nigroviridis_ENSTNIP00000019169 -SLVGNKLVTLPPS-----------------------------LGQLTRLHTLDVSLNLLQ----------------QLPDEIGSLG--------------------SLVRLEI------ O_latipes_ENSORLP00000007907 -SLLGNMLESLPPS-----------------------------LSQLKTLQELDVSHNLLQ----------------KLPEETGGLS--------------------ELVKLDL------ M_domestica_ENSMODP00000018737 -SVSSNCLRALPTG-----------------------------VARLSALQRLDLSENLLE----------------SVPEEIGALS--------------------GLTELSL------ O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA DVQGKNGVTPLHVASHYDHQKVALLLLEKGASPYSPAKNGHTPLHIASKKNQLNIATTLLDYKADANAESKTGFTPLHLSAQEGHGDMARVLLDNGADPNHAAKN--GLTPLHLCAQEDH T_guttata_ENSTGUP00000005529 NAAGKNGLTPLHVAVHHNNLEIVKLLLPKGSSPHNSAWNGYTPLHIAAKQNQMEVASSLLQYGASANAESLQGVTPLHLASQEGHADMVALLFSKQANGNLGNKS--GLTPLHLVAQEGH A_aegypti_AAEL013466-PA DVQGKNGVTPLHVASHYDHQKVALLLLEKGASPYSPAKNGHTPLHIASKKNQMDIANTLLEYKADANAESKTGFAPLHLSAQEGHRDMSKLLLDNGANPNHAAKN--GLTPLHLCAQEDH O_latipes_ENSORLP00000008143 NAAGKNGLTPLHVAVHHNNLDVVNLLVSKGGSPHSAARNGYTALHIAAKQNQVEVANSLLQHGASANAESLQGVTPLHLASQEGRPDIVSLLISKQANVNLGNKS--GLTPLHLVAQEGH E_caballus_ENSECAP00000009629 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKS--GLTPLHLAAQEDR P_pygmaeus_ENSPPYP00000020798 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGH A_carolinensis_ENSACAP00000001474 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHASAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIAPVHLASQEGHVDMVSLLLTRNANVNLSNKAKNGLTPLHLAAQEDR D_rerio_ENSDARP00000077097 NAAGKVGLTPLHVAVHHNNLDVVNLLLSKGGSPHSAARNGYTPLHIASKQNQAEVASSLLQHGASANAESLQGVTPLHLASQEGQPDMVLLLISKQANVNLGNKS--GLTPLHLVAQEGH G_gorilla_ENSGGOP00000011462 XXXXXNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXS--GLTPLHLVAQEGH D_melanogaster_FBpp0088239 DFQGKNDVTPLHVATHYNNPSIVELLLKNGSSPNLCARNGQCAIHIACKKNYLEIAMQLLQHGADVNIISKSGFSPLHLAAQGGNVDMVQLLLEYGV-ISAAAKN--GLTPLHVAAQEGH M_mulatta_ENSMMUP00000032129 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVDVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS--GLTPLHLVAQEGH 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ---------------ASNRLQSLPASLA-----------------------------------------------GLRSLRLLVLHSNLLASVPADLARLPLLTRLDL------------ M_mulatta_ENSMMUP00000021972 ---------------ASNRLQSLPASLA-----------------------------------------------GLRSLRLLVLHSNLLASVPAGLARLPLLTRLDL------------ P_pygmaeus_ENSPPYP00000003356 ---------------ASNRLQSLPASLA-----------------------------------------------GLRSLRLLVLHSNLLASVPAGLARLPFLTRLDL------------ P_troglodytes_ENSPTRP00000005532 ---------------ASNRLQSLPASLA-----------------------------------------------GLRSLRLLVLHSNLLASVPADLARLPLLTRLDL------------ B_taurus_ENSBTAP00000026157 ---------------ASNRLQSLPSSLA-----------------------------------------------GLRALRLFILHSNLLASVPASLARLPLLTRLDL------------ C_familiaris_ENSCAFP00000013991 ---------------ASNRLQGLPTSLV-----------------------------------------------GLRSLRLLVLHSNLLTSVPTGLVHLPLLTRLDL------------ M_musculus_ENSMUSP00000026580 ---------------ASNRLQSLPASLA-----------------------------------------------GLRSLRLLVLHSNLLTSVPTGLVHLPLITRLDL------------ G_gorilla_ENSGGOP00000010514 ---------------XXXXXXXXXXXXX-----------------------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------ R_norvegicus_ENSRNOP00000025291 ---------------ASNRLQHLPASLA-----------------------------------------------GLRSLRLLVLHSNLLTSVPPGLAHLPLITRLDL------------ G_gallus_ENSGALP00000022986 ---------------SGNRLSSIPDSLA-----------------------------------------------NLKSLWRLHLHSNLLVTVPASLASLPNLCRLDL------------ T_guttata_ENSTGUP00000010130 ---------------SGNRLLSIPESLA-----------------------------------------------NLKSLRRLHLHSNLLVTVPASLASLPNLSRLDL------------ A_carolinensis_ENSACAP00000015049 ---------------SGNLLTGIPASLA-----------------------------------------------NLQSLQQLHLHSNLLVTVPASLAHLPNLSRLDL------------ T_rubripes_ENSTRUP00000017044 ---------------SQNKLRQLPESMG-----------------------------------------------SLSSLRELFIYSNDIRVVPPCLNKLPLL-KIDM------------ G_aculeatus_ENSGACP00000007286 ---------------SHNKLRQLPDSMG-----------------------------------------------SLLALRELVIYSNEVRLIPRCLKELPLL-NMDV------------ T_nigroviridis_ENSTNIP00000019169 ---------------SQNKLRQLPESMG-----------------------------------------------SLSSLRELFIYSNDIRVIPPCLNKLPLL-KIDI------------ O_latipes_ENSORLP00000007907 ---------------SHNKLKQLPESMG-----------------------------------------------SLCSLRELVIYSNHLRMVPSCLNKLPQL-KIDA------------ M_domestica_ENSMODP00000018737 ---------------ASNLLQSLPDSLG-----------------------------------------------EGPS-------------------GAPNLQQAGL------------ O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA VGIAETLLEHKARIDPVTKTGFTPLHVAAHFGQAGMVKYLIENDANIEMKTNIGHTPLHQAAQQGHTLIINILLKNKANPEAVTNGGQTALSIADKLGYITVVETLKVVTETSV-TQ--- T_guttata_ENSTGUP00000005529 VLVADVLVKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYTPLHQAAQQGHTDVVTLLLKHGASPNEISTNGTTPLAIAKRLGYISVTDVLKIVTEETD-IP--- A_aegypti_AAEL013466-PA TEIAKVLLDHGANVEPATKTGFTPLHVGAHFGQINIVKFLLENDANIEMKTNIGHTPLHQAAQQGHTLIINLLLKNKANPEAVSNNGQTALSIADKLGYITVVETLKVVTETSV-TQ--- O_latipes_ENSORLP00000008143 VGIADILVKQGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQANVNSKTRLGYTPLHQAAQQGHTDIVTLLLKHDAQPNEITTHGTSALAIAKRLGYISVIDVLKLVTEETV-SM--- E_caballus_ENSECAP00000009629 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEETVTTT--- P_pygmaeus_ENSPPYP00000020798 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDVVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS-FV--- A_carolinensis_ENSACAP00000001474 VNVAEVLVNQGATVDAQTKMGYTPLHVGCHYGNIKMVNFLMQQFAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNGASPNELTVNGNTALAIAKRLGYISVVDTLKVVTEETMTAI--- D_rerio_ENSDARP00000077097 VGIADILVKHGASVYAATRMGYTPLHVACHYGNIKMVKFLLQQQANVNCKTRMSYTPLHQAAQQGHTDIVTLLLKHGAQPNEVTSNGTSALAIAKRLGYISVIDVLKLVTEETV-TM--- G_gorilla_ENSGGOP00000011462 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX--- D_melanogaster_FBpp0088239 VLVSQILLEHGANISERTRNGYTPLHMAAHYGHLDLVKFFIENDADIEMSSNIGYTPLHQAAQQGHIMIINLLLRHKANPNALTKDGNTALHIASNLGYVTVMESLKIVTSTSVINSNIG M_mulatta_ENSMMUP00000032129 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDVVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS-FV--- 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 -RDNQLRDLPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021972 -RDNQLRDLPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003356 -RDNQLRDVPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000005532 -RDNQLRDLPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000026157 -RDNQLRDVPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000013991 -RDNQLRDVPPELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000026580 -RDNRLRDLPAELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000010514 -XXXXXXXXXXXXXXXXXXXXXXXX----------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000025291 -RDNQLRDLPAELLDAPFVRLQGNP----------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000022986 -QNNCLRAVPPEIQTAPFVHLRGNP----------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010130 -QNNCLRAIPAEIQALPFVHVRGNP----------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015049 -QNNRLRTIPPEIQSLPFVHLRGNP----------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000017044 ---------------------RGNP----------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000007286 ---------------------RDNP----------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019169 ---------------------RGNP----------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000007907 ---------------------RDNP----------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000018737 ---------MPWPVLLPLVA---------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020641 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009937-PA TVDEKFKIVGPETIHETFLSDSEDE---------------------GEDPIMSDQQQYNYMTSDENKQFD--------------------------DTNLT-NMSIDPLKDDKYLEKIIS T_guttata_ENSTGUP00000005529 AVGDKHRMSFPETVDE-ILDVSEDE----------------------GEGWEG-QCGR-----QQSRGWHWCS----------------CWKRDTPRPGDLVESPAVLQVPCVPPETVVT A_aegypti_AAEL013466-PA TVDEKFKIVAPETIHETFMSDSEDE---------------------GEDPIMSDQQQYNYMTSDENKPFD--------------------------DTNIT-NMSIDPMKDEKYLEKIIS O_latipes_ENSORLP00000008143 TTTEKHRMSFPETVDE-ILDVSEDE--------------GIAQLTLEGEELLGTEGARY-MKMDDMKDHDAD--------------------FLSPKKSLENYSPAIPRIPRVSPETVIL E_caballus_ENSECAP00000009629 TITEKHKMNVPETMNE-VLDMSDDEVRKANAPEMLSDGEYIS-DVEEGEDAMTGDTDKY-LGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVP P_pygmaeus_ENSPPYP00000020798 LVSDKHRMSFPETVDE-ILDVSEDE----------------------GEELIGSKAER-----QDSRDVDEEK----------------ELLDFVPKLDQVVESPAIPRIPCVTPETVVI A_carolinensis_ENSACAP00000001474 TVIEKHKMNVPETMNE-VLDMSDDEVRKANVPEILSDGEYISDDGEEGEDAMTGDTDKY-LGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYVRDSMMIEELLVP D_rerio_ENSDARP00000077097 TTTEKHRMSFPETVDE-ILDVSEDE--------------GIAQLTLAGEELLGNEGARYLMKMEDIKDHDED--------------------FLSPKKVLE-YEGELEITLKVN--ISVI G_gorilla_ENSGGOP00000011462 LVSDKHRMSFPETVDE-ILDVSEDE----------------------GEELIGFKAER-----RDSRDVDEEK----------------ELLDFVPKLDQVXXXXXXXXXXXXXXXXXXX D_melanogaster_FBpp0088239 AIEEKLKVMTPELMQETLLSDSDDE---------------------SCDDLL-DHNHYKYMATDDLKA--------------NYGQDQKNFDTTNTDHDLT-DVSVLNKKEILP------ M_mulatta_ENSMMUP00000032129 LVSDKHRMSFPETVDE-ILDVSEDE--------------GTAHITIMGEELIGSKPER-----PDSRDVDEEK----------------ELLDFVPKLDQVVESPAIPRIPCVTPETVVI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 -------------------LGEASPDAPSSPVA-------------ALIPEMPRL---------FLTSDL----DSFPVTPQGCSV--TLACGVRLQFPAGATATPITIRYRLLLPEP-- M_mulatta_ENSMMUP00000021972 -------------------LGEASPDVPSSPVA-------------ALIPEMPRL---------FLTSDL----DSFPVTPRGCSV--TLACGVRLQFPAGATATPITIRYRLLLPEP-- P_pygmaeus_ENSPPYP00000003356 -------------------LGEASPGAPSSPVA-------------ALIPEMPRL---------FLTSDL----DSFPVTPRGCSV--TLACGVRLQFPAGATATPITIHYRLLLPEP-- P_troglodytes_ENSPTRP00000005532 -------------------LGEASPDAPSSPVA-------------ALIPEMPRL---------FLTSDL----DSFPVTPRGCSV--TLACGIRLQFPAGATATPITIRYRLLLPEP-- B_taurus_ENSBTAP00000026157 -------------------LGRPPPDPPSPPGP-------------PVVPEMPRL---------LLTSDR----DSFAVTPQGCSV--TLACGVRLQFPAGATAAPMTIRYRLWLPEP-- C_familiaris_ENSCAFP00000013991 -------------------LGEALPAPQSPPEA-------------PVILEMPRL---------FLNSDV---DNSFPVTPQGCSV--TLACGVRLQFPAGATASPVNIQYRLWLPEP-- M_musculus_ENSMUSP00000026580 -------------------LGEASPAPPSPPDI-------------SQVPEMPRL---------LLTSDL----DSFLVTPHGCSV--TLACGVRLQFPAGATTTPVTIHYRLWLPEP-- G_gorilla_ENSGGOP00000010514 -------------------XXXXXXXXXXXXXX-------------XXXXXXXXX---------XXXXXX----XXFPVTPRGCSV--TLACGVRLQFPAGATATPITIXYRLLLPEP-- R_norvegicus_ENSRNOP00000025291 -------------------LGEASPAPPSPPDI-------------SQVPEMPRL---------FLTSDL----DSFLVTPHGCSV--TLACGVRLQFPAGATTTPITIHYRLWLPEP-- G_gallus_ENSGALP00000022986 -------------------LGEAEPSLQADESS---------------ATELRRL---------FLASEE---DRSFTVTSEGCEV--VLACGIRFYFPPEAASDPLQIYFRTLAPDP-- T_guttata_ENSTGUP00000010130 -------------------LGETEPSPQAGNRS-------------GEVPKRPRL---------LRIYIT---DKGFTVASEGCRV--VLACGIHFYFPPGAASDPVRIHFRSLTPDP-- A_carolinensis_ENSACAP00000015049 -------------------LGEPEVPLQPENRV---------------VVLQKQC---------FLSLCL----LSFIVTPDGCRV--SLACGIQLSFPPGATTTSVTIHFQKCFPDP-- T_rubripes_ENSTRUP00000017044 -------------------LGRPPTPPPLPPVP--------------AVIYTAVL----------------LLLFSFCVSPAGRHV--FLPGGAELLFPPGCLLTTTRLEWVEKTPEK-- G_aculeatus_ENSGACP00000007286 -------------------LGQSPTPPPLSPTPGERRKRSNRNENSRAAPRIPPA---------QITDVMLPLLLSFCVSPAGCHV--FLPGGAELLFPPGCLVTTTSLEWAEKRSER-- T_nigroviridis_ENSTNIP00000019169 -------------------LGRPPTPPPLPPAP--------------DITSAGELSEMSRISEQELTPRCSFCFFRFFVSPPGCHV--FLPGGAELLFPPGCLSATRRIEWEEKRPEK-- O_latipes_ENSORLP00000007907 -------------------LGKPPTPPPLPPTLG------------RSVTEMPEL---------HLGFNQ----HSFWVTPAGCHV--FLPGGAELVFPCRCLLTTTRLSWAEKRPNR-- M_domestica_ENSMODP00000018737 -------------------LGASSPP------------------------------------------------------------------------PPGRSPGS-------------- O_anatinus_ENSOANP00000020641 ---QHLTF------TREFDSDSLRHYSWAADTL-------------DNVNLVSSP---------IHSGFL----VSFMVDARGGAMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLA A_gambiae_AGAP009937-PA RAENY---------TVSAMDRSHTPNPLDITVT-------------DNVNITRKP---------IHVGFM----VSFLVDARGGAMRGCRHSGVRVIVPPRSAAQPTRITCRYVKPQRIT T_guttata_ENSTGUP00000005529 RAEETEQP------SKEFDEDSLIPSSPATETS-------------DNISPVASP---------VHTGFL----VSFMVDARGGSMRGSRHHGLRVVIPPRACAAPTRITCRLVKPQKLP A_aegypti_AAEL013466-PA NAEKY----------PSMTPRESTPNPLDITVT-------------DNVNITRKP---------IHVGFL----VSFLVDARGGAMRGCRHSGVRVIVPPRSAAQPTRITCRYVKPQRIT O_latipes_ENSORLP00000008143 KEQEITQQHTPLPLPKEYDEDSLIPSSPATETS-------------DNVSPVASP---------IHTGFL----VSFMVDARGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLT E_caballus_ENSECAP00000009629 SKEQHLTF------TREFDSDSLRHYSWAADTL-------------DNVNLVSSP---------VHSGFL----VSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLA P_pygmaeus_ENSPPYP00000020798 RSEEQEQA------SKEYDEDSLIPSSPATETS-------------DNISPVASP---------VHTGFL----VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS A_carolinensis_ENSACAP00000001474 SKDQHQTF------PKEYDSDSLRHYSWAADTL-------------DNVNLVSSP---------IHSGFL----VSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLA D_rerio_ENSDARP00000077097 TPCVYVQQHTPLPLPKEYDEDSLIPSSPATETS-------------DNVSPVASP---------IHTGFL----VSFMVDARGGSMRGSRHNGLRVIIPPRTCAAPTRITCRLVKPQKLP G_gorilla_ENSGGOP00000011462 XXXXXXXA------SKEYDEDSLIPSSPATETS-------------DNISPVASP---------VHTGFL----VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLXKPQKLS D_melanogaster_FBpp0088239 ------------------NEMSCIELTEIGHKP-------------DNVVIARSQ---------VHLGFL----VSFLVDARGGSMRGYRHNGVRIIVPPKACAEPTRITCRYVKPQRVV M_mulatta_ENSMMUP00000032129 RSEEQEQA------SKEYDEDSLIPSSPATETS-------------DNISPVASP---------VHTGFL----VSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 GLVPLGPHDALLSHVLELQPH-GVAF---QQDVGLWLLFTPP--QARRCRE-VVVRTRNDNSWGDLETYLE--------------------EEAPQ-RLWAHCQVPHFSWFLVVSRPVSN M_mulatta_ENSMMUP00000021972 GLVPLGPHDALLSHVLELQPHGGVAG---GSDVGLWLLFTPP--RARRCRE-VVVRTRNDNSWGDLETHLE--------------------EEAPQ-RLWAHCQAPHFSWFLVVSRPVSN P_pygmaeus_ENSPPYP00000003356 GLVPLGPHDALLSHVLELQPH-GVAF---QQDVGLWLLFTPP--RARRCRE-VVVRTRNDNSWGDLETYLE--------------------EEAPQ-RLWAHCQAPHFSWFLVVSRPVSN P_troglodytes_ENSPTRP00000005532 GLVPLGPHDALLSHVLELQPH-GVAF---QQDVGLWLLFTPP--RARRCRE-VVVRTRNDNSWGDLETYLE--------------------EEAPQ-E---------------------- B_taurus_ENSBTAP00000026157 RLVPLGPHDALLSGVLELQPH-GVAF---QQEVGLWLLFVPP--RARRCRE-VVVRTLSDNSWSDLETHLE--------------------EETPK-RLWAHCQVPHFSWFLVVSRPVSD C_familiaris_ENSCAFP00000013991 RLVPLGPHDSLLSGVLELQPH-GVAF---RQKVSLWLLFVPP--RIRRCRE-VVVRTLSGDSWGDLDTHVE--------------------EEAPK-RLWAHCQVPHFSWFLVVSRPVSN M_musculus_ENSMUSP00000026580 GLVSLGPHDFLLSSVLELQPH-GVAF---QQDVSLWLLFVPP--RVRRCRE-VVVRTRSNNTWNDLETQLE--------------------EEAPK-RLWARCQVPHFSWFLVVLRPVSN G_gorilla_ENSGGOP00000010514 GLVPLGPHDALLSHVLELQPH-GVAF---QQDVGLWLLFTPP--RARRCRE-VVVRTRNDNSWGDLETYLE--------------------EEAPQ-RLWAHCQAPHFSWFLVVSRPVSN R_norvegicus_ENSRNOP00000025291 GLVSLGPHDFLLSGVLELQPH-GVAF---QQNVSLWLLFVPPRVRVRRCRE-VVVRTRSDNIWNDLETHLE--------------------EEAPK-RRWARCQVPHFSWFLVVLRPVSN G_gallus_ENSGALP00000022986 QWVKLRHHDVLLSKVLELQPH-GVKF---QQEVEIWMPYASP--ETLHQRE-VVVRTFSGQSWSDLRTQVE--------------------KKRKSKKHVAHCSVLHFSWFLVVSRLVQN T_guttata_ENSTGUP00000010130 QWVKLRHHDVLLSRVLELQPH-GVQF---QQEVHIWMPYISP--QTPHKHE-VVVRTFSGQSWNDLKTRVK--------------------QKRKS-KCVAHCCVLHFSWFLVVSRLVQN A_carolinensis_ENSACAP00000015049 QWVKLKHHDVLLSKVLELQPH-GIGF---QKEVQIQMPYASP--QSLNDRE-IIIRTLSGEKWSELGTRVK--------------------HKGK--MHFACCSVPHFSWFVVVSRLVEN T_rubripes_ENSTRUP00000017044 TLVHLEEHEILLSCPLELRPH-GIKF---FKPVEVCVPY-----HRPKRTE-VVVQRFDGFSWSTLPTVLR--------------------RGRKHRS-LACCTVRQFSWFMVVSRPVKD G_aculeatus_ENSGACP00000007286 KWVWLEEHDILLSRPLELRPH-GITFLKVLKPVEVCVPY-----HRAKRRE-VLVRRFDGQSWSTLPTFLR--------------------KGSPSHS-LACCAVSQFSWFMAVSRPLKD T_nigroviridis_ENSTNIP00000019169 KLVHLEEHEILLSCPLELQPH-GIKF---LKPVEVCVPY-----HRPKRTE-VVVLKFDGLSWSPLPTALR--------------------RGSKHRSAYHRGRVPRFSWFMVVSRPVKD O_latipes_ENSORLP00000007907 KWVWLEEHDLLLSRPLELRPH-GVEF---LKPVEVCVPY-----HRRKRRE-VVVRRFDGELWSTLAAD------------------------------LACCSVRSFSWFMAVGRPVLD M_domestica_ENSMODP00000018737 --------------------------------------FLPP----------------------------------------------------------LHLPVPHYNLTPAMSP---- O_anatinus_ENSOANP00000020641 HPPPMVEGEGLASRLVEMGPA-GAQF---LGPVIVEIPHFGS--MRGKERELIVLRSENGETWKEHQYDSKQEDLNELLNGM--DEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQE A_gambiae_AGAP009937-PA NGPPLMEGEALVSRILELAPV-GAKF---LGPVILEVPHFAS--LRDKEREIIILRSDNGETWREHTLYDSEEAIHEVLNETFKGDTLNLLEDLHTNRITRIVTNDFPHYFAIVSRIRQE T_guttata_ENSTGUP00000005529 APPPLAEEEGLGSRIIALGPA-GAQF---LSPVIVEIPHFAS--YGRGDRELVVLRSENGSVWKEHRNRYEESYMDQLLNGM--DEELESQEELDKKRVCRIITTDFPLYFVVMSRICQD A_aegypti_AAEL013466-PA NAPPLMEGEALVSRILELAPV-GAKF---LGPVIIEVPHFAS--LREKEREIIILRSDNGETWREHTLYDSEEAIHDVLNDTFKGDTLNLLEDLHTNRITRILTNDFPHYFAIVSRIRQE O_latipes_ENSORLP00000008143 SPPPLVEGEGLASRIISLGPA-GMQF---LGPVIVEIPHFAA--LGRGDRELVVLRSENGSVWKEHRNRYGDEVLETILNGM--DEELESQEELGKKRIRRIISTDFPLYFAVVSRVQQE E_caballus_ENSECAP00000009629 NPPPMVEGEGLASRLVEMGPA-GAQF---LGPVIVEIPHFGS--MRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGM--DEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQE P_pygmaeus_ENSPPYP00000020798 TPPPLAEEEGLASRIIALGPT-GAQF---LSPVIVEIPHFAS--HGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQD A_carolinensis_ENSACAP00000001474 SPPPMVEGEGLASRLVEMGPS-GAQF---LGPVIVEIPHFGS--MRGKERELIVLRSENGETWKEHQFDSRHENLSEILNGM--NEELDSVEELEKKRICRIITKDFPQYFAVVSRIKQE D_rerio_ENSDARP00000077097 TPPPLVEGEGLASRIISLGPA-SMQF---LGPVIVEIPHFAA--LGRGDRELVVLRSENGSVWKEHRNRYGDEVLETILNGM--DEDLESQEELGKKRIRRIISTDFPLYFAVVSRIQQE G_gorilla_ENSGGOP00000011462 TPPPLAEEEGLASRIIALGPT-GVQF---LSPVIVEIPHFAS--HGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQD D_melanogaster_FBpp0088239 NPPPLMEGEALVSRILEMSPV-DGMF---LSPITLEVPHYGT--LRKNEREIIILRSDNGESWREHNLYKD-----------IIGEDINQTEEFHSDRIVRIVTQNVPHFFAVVSRVRQE M_mulatta_ENSMMUP00000032129 TPPPLAEEEGLASRIIALGPT-GAQF---LSPVIVEIPHFAS--HGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQS-GPPSFLQPVTVQLPLPSGITGLSLDRS---------RLHLL---YWAPPAATW M_mulatta_ENSMMUP00000021972 ACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQS-GS---LSPLTLPSP------GLSLDRS---------RLHLL---YWAPPAVTW P_pygmaeus_ENSPPYP00000003356 ACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQN-GPPSFLRPVTVQLPLPSGITGLSLDRS---------RLHLL---YWAPPAATW P_troglodytes_ENSPTRP00000005532 --------------------------------------VRMAGRELQALLGEPEDAMSPLLCLSQS-GPPSFLRPVTVQLPLPSGITGLSLDRS---------RLHLL---YWAPPAATW B_taurus_ENSBTAP00000026157 ACLVPPEGTLLCSSGHAGVRVTFPAGATEEPRHVRMQVVRVGSRELPALLGEPEAASSPLLCLSQS-GPSSFLRPVTIQLPLPPGVTGLSLDRA---------RLHLL---HRAAPAAAW C_familiaris_ENSCAFP00000013991 TCLVPPEGTLLCCSGYPGVKVTFPPGATEEPRSVCMQVVRMASRELRALLGEPEAAASPLLCLSQSGGPPSFLQPVTVQLPLPPGVTGLSLDRS---------CLHLL---YRTPLEAAW M_musculus_ENSMUSP00000026580 TCLLPPEGALLCSSGHPGVRVTFPPGVTEEPRQVSMQVVHMAGLELRTLLEESEASVSPLLCLSQS-GPPSFLQPVTVQLPLPPGVTGFSLDRS---------HLHLL---YRTPLTTTW G_gorilla_ENSGGOP00000010514 ACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALLGEPEAAVSPLLCLSQS-GPPSFLRPVTVQLPLPSGITGLSLDRS---------RLHLL---YWAPPAATW R_norvegicus_ENSRNOP00000025291 TCLLPPEGALLCSSGHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALLEESEAAVSPLLCLSQS-GPPSFLQPVTVQLPLPPGVTGFSLDRS---------HLHLL---YRTPLTSTW G_gallus_ENSGALP00000022986 ECKVPTEGTLLFSSVDPNIKVTFPPGVTEETRNVKLQVLPVSAEEIAELTADAGCKASPLLCLSQD-SLVDFLRPVRIQLPLPFGVTGLNLDRS---------RLHLL---CGDVEGQTW T_guttata_ENSTGUP00000010130 ECKVPAEGTLLFSSVDPNIKVIFPPGVTKEPRSVKLQVLPVSAEEIQEITANAGCRASPLLYLSQD-STVDFLKPVRIQLPLPPGVTGLNLDRS---------RLHIL---HGDLEGQTW A_carolinensis_ENSACAP00000015049 ECRVPQEGALLFSTVDPNIKVTFPPGVTEETRTVKLQVLPVSAEELQEITEDNEMVTSPLLFLSQN-SPADFLQPVKIQLPLPPGVTGLTLDRS---------RVHLL---HGDRNAQNW T_rubripes_ENSTRUP00000017044 SCSLTSAGTLLVSSADPGIKLHFPPDSTLENRTVTLQVLQVSAAEIQVLCGDPQARVSPLLCLSQN-PSTDFLQPVKVQVPLPPGVTGHTADMS---------CLHLL---HGDPAAQSW G_aculeatus_ENSGACP00000007286 SCSVTPTGALLVSSADDGVKLRFPPDCTVQSRTVTLQVLQVSVSQVRALCGDPQASVSPLLCLSQD-PSIHFLQRVEVQVPLPSGVTGQTCDLS---------CLHLL---HGDATAQTW T_nigroviridis_ENSTNIP00000019169 SCSLTSAGTLLVSSIDPGIKLHFLPDCTLENRTVTLQVLQVSSAEVQALCGDPQAQVSPLLCLSQN-PSTDFLQPVKVQVPLPPGVTGQTADMS---------CLHLL---HGDPSAQTW O_latipes_ENSORLP00000007907 TCSVTPAETLLVSSADPGIKLHFPPDSTAQTRSVTLQVLQVSESTVQTLCGDPQARVSPLLCLSQN-PCLHFLQPVKVQIPLPSGLTGHTMDLS---------CLHLL---HGDPAAQTW M_domestica_ENSMODP00000018737 ----KADGT-------GNVQETHPACVDEFAGRDGIS---------KDLQEDLEHAISTLLCVSQD-KP-PFIGPVTVQLTLPPSITSMSLDRA---------RIHLL---HGDPGVPAW O_anatinus_ENSOANP00000020641 SNQIGPEGGLLSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTVEP--RRRKFHKPITMTIPVPPPSGEGTTNGFKGE---ITPSLRLLCSITGGTSPAQW A_gambiae_AGAP009937-PA VHAIGPEGGTVSATAVPQVQAIFPQNALTKKIRVGLQAQPIDMNTTANLLGR-SVAVSPVVTVEP--RRRKFHKAITLSMPAPKAYNSGMINQYSGN----APTLRLLCSITGGQNKAVW T_guttata_ENSTGUP00000005529 CDMIGPEGGCLKSTLVPMVQATFPDTAVTKRVRLALQAQPVPDELVTKLLGN-QATFSPIVTVEP--RRRKFHRPIGLRIPLPPSWKDNPRDSGEGD---TT-SLRLLCSVIGGTAQAQW A_aegypti_AAEL013466-PA VHAIGPEGGTVSATAVPLVQAIFPQNALTKKIRVGLQAQPIDMNTTANLLGR-SVAVSPVVTVEP--RRRKFHKAITLSMPAPKAYNSGMINQYSGN----APTLRLLCSITGGQNKAVW O_latipes_ENSORLP00000008143 SDLIGPEGGSLTSKLVPMVQATFPETAVTKRVRLGLQAQPVPDELVAKLLGN-QANFSPVVTVEP--RRRKFHRPIGLRIPLPPSWRDSPRDSGEGD---TT-SLRLLCSVIGGTASAQW E_caballus_ENSECAP00000009629 SNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGN-KATFSPIVTVEP--RRRKFHKPITMTIPVPPPSGEGVSNGYKGD---TTPNLRLLCSITGGTSPAQW P_pygmaeus_ENSPPYP00000020798 YDTIGPEGGSLKSRLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFSPIVTVEP--RRRKFHRPIGLRIPLPPSWTDNPRDSGEGD---TT-SLRLLCSVIGGTDQAQW A_carolinensis_ENSACAP00000001474 SNQIGPEGGVLSSTTVPHVKASFPEGALTKRIRVGLQAQPVPDEAVKKILGN-KATFSPIVTVEP--RRRKFHKPITMTIPVPPPSGEGITNGYKGD---TTPSLRLLCSITGGTSPAQW D_rerio_ENSDARP00000077097 NDLIGPEGGFLSSKLVPMVQATFPETAVTKRVRLGLQAQPVPDELVAKLLGN-QATFSPVVTVEP--RRRKFHRPIGLRIPLPPSWRESPRDAGEGD---TT-SLRLLCSVIGGTAPAQW G_gorilla_ENSGGOP00000011462 YDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFSPIVTVEP--RRRKFHRPIGLRIPLPPSWTDNPRDSGEGD---TT-SLRLLCSVIGGTDQAQW D_melanogaster_FBpp0088239 VHVIGPDGGTVFSTAVPQVKAIFPPHALTKKIRVGLQAQSVDLVECSKLLGQ-GVAVSPVVTVEP--RRRKFHKAITLSIPAPKACTNSMVNACYGNGNSSSPTLRLLCSISGGQTRATW M_mulatta_ENSMMUP00000032129 YDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGN-QATFSPIVTVEP--RRRKFHRPIGLRIPLPPSWTDNPRDSGEGD---TT-SLRLLCSVIGGTDQAQW 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 DDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERG M_mulatta_ENSMMUP00000021972 DDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERG P_pygmaeus_ENSPPYP00000003356 DDITAQVGLELTHLYARFQVTHFSWYWLWYTTKNC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERG P_troglodytes_ENSPTRP00000005532 DDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERG B_taurus_ENSBTAP00000026157 DDITAQVALELTHLYARFQVTRFSWYWLWYTTKAC-VGSLARKAWER----LRL--YRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRG-EPSDTVEMFEGEKFFAAFERG C_familiaris_ENSCAFP00000013991 DDITAQVALELTHLYARFQVTHFSWYWLWYTTRPV-C-----KTWLESLGALRL--HESSH-CLQRRPDPEQVLLQ--CLPGDKVDATLRRLLDRYRGPEPSDTVEMFEGEKFFAAFEKG M_musculus_ENSMUSP00000026580 DDITTQVALEFTHLYARFQVTHFSWYWLWYTTKTC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRNKVDATLSRLLVRYRGPEPSETVEMFEGEKFFAAFERG G_gorilla_ENSGGOP00000010514 DDITAQVVLELTHLYARFQVTHFSWYWLWYTTKNC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPQNKVDATLRRLLERYRGPEPSDTVEMFEGEEFFAAFERG R_norvegicus_ENSRNOP00000025291 DDISTQVALEFTHLYARFQVTHFSWYWLWYTTKTC-VGGLARKAWER----LRL--HRVNLIALQRRRDPEQVLLQ--CLPRSKVDATLSRLLDRYRGPEPSETVEMFEGEKFFAAFERG G_gallus_ENSGALP00000022986 DDITSQVVLEFTHLYAVFEVTHFSWYWLWYTTKTY-IGGIAKKVYER----LRM--YQVNFIALQRRKDPEQVLLQ--CLPKHKVDTVLKKLQDRYRGPEPSDMVEMFEGEQFFAAFERG T_guttata_ENSTGUP00000010130 NDITSEVVLEFTHLYAVFEVTHFSWYWLWYTTKTY-IGGIAKKVYER----LRL--YQVNFIALQRKRDPEQVLLQ--CVPKHKVDPVLRKLQDRYRGPEPSDMVEMFEGEQFFAAFERG A_carolinensis_ENSACAP00000015049 DDITDQVVLEFTHLYALFEVTHFSWYWLWCTTKSY-IDGIAKKVYKR----LRM--YQVNFIALQRKKDPEQVLLQ--CVPKHKVDPVLKKLQDRYRGPEPSDMVEMLEGEQFFAAFERG T_rubripes_ENSTRUP00000017044 TDITSQVSLYVTHVYAIFYITHFSWYWLWYTTQRI-VCGTVRKVYQK----LKQ--FKVQFLVLQRKTDPSQVILQ--CLPSNKVDNRVQSLAELYDGPQPSDMCDLLEGEQFFAGFERG G_aculeatus_ENSGACP00000007286 TDITSQVSLCVSHLYATFYITHFSWYWLWYTTQQC-VSGVVRKVYQR----LKQ--FKVQFLVLQRKTDPSQVMLQ--CLPANRVDGRVQSLSERYDGPQPSDLCDLLEGEQFFAGFERG T_nigroviridis_ENSTNIP00000019169 TDITSQVSLYVTHAYAVFYITHFSWYWLWYSTQKV-ICGTVRRIYQK----LKQ--FKVQFLVQQRKSDPSQVMLQ--CLPSNKVDSRVQSLSELYDGPQPSDVCDLLEGEQFFAGFESG O_latipes_ENSORLP00000007907 TDITSQVSLYVTHLYAIFYITHFSWYWLWYTTQRC-VSGVVRKVYQR----LKQ--FKVQFLVLQRRTDPSQVLLQ--CLPTNKVESRVKFLSEQYDGPQPSDLCDLLEGEQFFAGFERG M_domestica_ENSMODP00000018737 SDITAQVALDLTYLYARLQITHFSWYWLWYTTKSC-VEGLARKVYDR----LRL--YRVNFIALQRRRDPEQVLLQ--CLPGRKVEPTLKRLQPRYRGPEPSDTVELFEGERFFAAFEQG O_anatinus_ENSOANP00000020641 EDITGTTPLTFIKDSVSFTTNVSARFWLADCHQVLETVGLATQLYRE----LICVPYMAKFVVFAKTNDPVESSLRCFCMTDDKVDKTLEQ-QENFEEVARSKDIEVLEGKPIYVDCYGN A_gambiae_AGAP009937-PA EDVTGSTPLTFVNDCVSFTTTVSARFWLMDCRNIGEATKMATELYSQ----MAHVPFMVKFVVFAKRVDQSEAKLSVFCMTDDKEDKTLEH-QEHFTEIAKSRDIEVCEGRTVYLEFAGN T_guttata_ENSTGUP00000005529 EDITGTTKLIYENECANFTTNVSARFWLADCPRTAEAVHFATMLYKE----LTAVPYMAKFVVFAKMNDAREGRLRCYCMTDDKVDKTLEQ-HENFTEVARSRDIEVVEGMPLHVELSGN A_aegypti_AAEL013466-PA EDVTGSTPLTFVNDCVSFTTTVSARFWLMDCRNINEATKMATDLYSQ----MSHVPFMVKFVVYAKRVDQNEAKLSVFCMTDDKEDKTLEH-QEHFTEIAKSRDVEVCEGRVVYLEFAGN O_latipes_ENSORLP00000008143 EDITGTTKLIYANDCASFTTNVSARFWLADCPRTAEAVSFANLLYRE----LSAVPYMAKFVVFAKMNELREGRLRCYCMTDDKMDKTLEQ-HENFAEVARSRDIEVMEGMPLHLECSGN E_caballus_ENSECAP00000009629 EDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRE----LICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQ-QENFEEVARSKDIEVLEGKPIYVDCYGN P_pygmaeus_ENSPPYP00000020798 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKE----LTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGN A_carolinensis_ENSACAP00000001474 EDITGTTLLTFVNDCVSFTTNVSARFWLADCHQIGETVGLATQLYRE----LICVPYMAKFVIFAKMNDAVESNLRCFCMTDDKVDKTLEQ-QENFEEVARSKDIEVLEGKPIYVDCYGN D_rerio_ENSDARP00000077097 EDITGTTKLAYSNDCASFTTNVSARFWLADCPRTAEAVSFANLLYRE----LSAVPYMAKFVVFAKMNEAREGRLRCYCMTDDKMDKTLEQ-HENFSEVARSRDIEVMEGMPLYLECSGN G_gorilla_ENSGGOP00000011462 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKE----LTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGN D_melanogaster_FBpp0088239 EDVTGSTPLSFVRDSVTFTTTVSARFWLIDCRNIIDAGRMATELYSH----LAKVPFYVKFVIFAKRISQTEAKFSVFCMTDDKEDKTLEQ-QEYFKEVAKSRDIEVLQNQIVYLEFAGN M_mulatta_ENSMMUP00000032129 EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKE----LTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQ-HENFVEVARSRDIEVLEGMSLFAELSGN 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 IDVDADRPDCVEGR--ICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVRVPEEAEAARQRKGADALWMATLPIKLP-RLR---------GS--EGPRRG------------ M_mulatta_ENSMMUP00000021972 IDVDADRPDCVEGR--ICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGTVPVQVPEEAEAARQRKGADALWMATLPIKLP-RLR---------SS--EEPRRR------------ P_pygmaeus_ENSPPYP00000003356 IDVDADRPDCVEGR--ICFVFYSHLKNVKEVYVTTALDREAQAVRGQVSFYRGAVPVQVPEEAEAARQRKGADALWMATLPIKLP-RLR---------GS--EGPRRG------------ P_troglodytes_ENSPTRP00000005532 IDVDADRPDCVEGR--ICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGAVPVQVPEEAEAARQRKGADALWMATLPIKLP-RLR---------GS--EGPRRG------------ B_taurus_ENSBTAP00000026157 IDIDADRPDCVEGR--LCFVFYSHLKNLKEVYVTTALDRRARAVRGQVSFYRGEVPEVVPEEAEAARQKRGPAALWMATLPIKLP-RLQ---------GC--EGPTRE------------ C_familiaris_ENSCAFP00000013991 IDVDAERPDCVEGR--VCFVFYSHLKNVKEVYVTTTLDRQVQAVRGQVSFYRGAVPEEVPEEAKAARQKKGMDTVWMATLPIKLP-RLR---------GSEGLGQGRG------------ M_musculus_ENSMUSP00000026580 IDVDADRPDCVDGR--ICFVFYSHLKNVKEVYITTALDREAQDVRGQVSFYRGSLPVEVPAEAEAARQRKGTDALWMATLPIKLP-RLR---------GA--QGSGQG------------ G_gorilla_ENSGGOP00000010514 IDVDADRPDCVEGR--ICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFYRGTVPVQVPEEAEAARQRKGADTLWMATLPIKLP-RLR---------GS--EGPRRG------------ R_norvegicus_ENSRNOP00000025291 IDVDADRPDCVDGR--ICFVFYSHLKNMKEVYITTALDREAQDVRGQVSFYRGSLPMEVPEEAEAARRRKGTDALWMATLPIKLP-RLR---------GA--QGSGQG------------ G_gallus_ENSGALP00000022986 ISIDMDRPDCVDGR--LSFIFYSHLKNMKEIYVTSPVDRKGQAVKGQVSFYRGAVPESIPE--DASRRRRGPDPLWLATLPIKLP-RLK---------PRWGETSSSL------------ T_guttata_ENSTGUP00000010130 ISIDMDRPDCVDGR--LSFVFYSHLKNMKEIYVTSPVDRKGQAVKGQVSFYRGAVPESIPE--DASRRRKGPDSLWLATLPIKLP-QLK---------AR-DENPGPL------------ A_carolinensis_ENSACAP00000015049 ISIDADRPDCIDGR--ISFNFFSHLKNVKEVYITSEVDRKSTAVKGQVSFYRGAVPENIPE--EVSKRRKGPDSHWLATLPIKLP-KLK---------SQENKQPTTS------------ T_rubripes_ENSTRUP00000017044 LDISTERPDCVEGR--LCFVFYSSLKNLKEVYICA-VEGHTGPVRGQVSFYRGEIPGDLPE--ELARKRKGHDNQWLATLPVKLPQAAD---------S---ENGFLV------------ G_aculeatus_ENSGACP00000007286 LDISTERPDCVEGR--LCFVFYSSLKNLKEVYICP-AQDQKGPVRGQVSFYRGECPSSLPE--EVARKRKGPDSQWLATLPLRLP-ALN---------S---ENSFMA------------ T_nigroviridis_ENSTNIP00000019169 LDISTERPDCVEGR--LCFVFYSSLRNLKEVYICA-AEGQTGPVRGQVSFYRGEAPSHLPE--EVARKRKGPDHQWLATLPVKLPSSLKPAPLLWSQAH---ENGFVV------------ O_latipes_ENSORLP00000007907 LDISTDSPDCVSGR--LCFVFYSSLKNLKEVYICP-VQGQTGPVRGQVSFYRGDIPSNLPE--EVAKKRKGLDSQWLATLPLRLP-ALN---------S---DNSFIL------------ M_domestica_ENSMODP00000018737 IAVEADRPDCVAGR--IAFVFYSHLKNVKEVYVTSTVDRKTQAVKGQVSFYRGAVPDAVPE--EAVRRRKAPDPLWFPPFPINFL-LTG---------GGGGEGQGPL------------ O_anatinus_ENSOANP00000020641 LA-----PLTKGGQQ-LVFNFYAFKEN--RLPFSIKIRDSSQEPCGRLSFLK-----------EPKTTKG-LSQAAVCNLNITLP-AHK---------KT--EKT-D------------- A_gambiae_AGAP009937-PA IV-----PVMKSGEQ-LSLQFNAFKEN--RLTFTVKIKNNLDDLLGRISFMN-----------EPKVAKGEPIQTPLCTLNFTLP-SEK---------FG--LGGDDLETTSEFDQSSTE T_guttata_ENSTGUP00000005529 LV-----PVKKAAQP-RTFLFQSFREN--RLVIPIKVRDSSREASGSLSFLR-----------KAMKYED--LQHVLCHLNISIP-PCT---------KG--SGSDE------------- A_aegypti_AAEL013466-PA II-----PVMKTGEQ-LSIQFNAFKEN--RLTFTVKIKSTLDELLGRISFMN-----------EPKVAKGEPTPTPLCTLSFTLP-PEK---------YG--LGGDEMETGSEFDQSSTE O_latipes_ENSORLP00000008143 LL-----PVRKATQQPRCFSFQAFRDN--RLPVTVKVRDSSKEPTGFLSFLR-----------KSTKYED--SQHVLCNLNITMP-PCI---------TM--RGSED------------- E_caballus_ENSECAP00000009629 LA-----PLTKGGQQ-LVFNFYAFKEN--RLPFSIKIRDTSQEPCGRLSFLK-----------EPKTTKG-LPQTAVCNLNITLP-AHK---------KT--EKT-D------------- P_pygmaeus_ENSPPYP00000020798 LV-----PVKKAAQQ-RSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLR-----------KAMKYED--TQHILCHLNITMP-PCA---------KG--SGAED------------- A_carolinensis_ENSACAP00000001474 LA-----PLTKGGQQ-LVFNFYAFKEN--RLPFSIKIRDTSQEPCGRLSFLK-----------EPKTTKG-LPQTAVCNLNITLP-AHK---------KT--EKT-D------------- D_rerio_ENSDARP00000077097 LV-----PIRKAAQQPRCFSFQAFKDN--RLPVSVKVRDSSKDPSGFLSFLR-----------KSTKYED--SQHVLCNLNVTMP-PCI---------KI--MGSDE------------- G_gorilla_ENSGGOP00000011462 LV-----PVKKAAQQ-RSFHFQSFREN--RLAMPVKVRDSSREPGGSLSFLR-----------KAMKYED--TQHILCHLNITMP-PCA---------KE--SGAED------------- D_melanogaster_FBpp0088239 IV-----PILKKGEQ-LYTKFQPFCEN--RLSFSAHIKDQ-EFPHGRICFMT-----------YPMVGPDEVPLKPLCTLNISVD-FKT---------ITNHLERDNLHSLNDCINAHGK M_mulatta_ENSMMUP00000032129 LV-----PVKKAAQQ-RSFHFQSFREN--RLAIPVKVRDSSREPGGSLSFLR-----------KAMKYED--TQHILCHLNITMP-PCS---------KG--SGAED------------- 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ----AGLSLAPLNL--------------GDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEF-RDDLDEQIRHMLFSWAERQ-AGQPGAVGLLVQALEQSDRQDVAEEV M_mulatta_ENSMMUP00000021972 ----AGLSLAPLNL--------------GDAETGFLTQSNLLSVAGRLGPDWPTVALHLGVSYRELQRIRHEF-RDDLDGQIRHMLFSWAERQ-AGQPGAVGLLVQALEQSDRQDVAEEV P_pygmaeus_ENSPPYP00000003356 ----AGLSLAPLNL--------------GDAETGFLTQSNLLSVAGRLGPDWPAVALHLGVSYRELQRIRHEC-R--------------------------------------------- P_troglodytes_ENSPTRP00000005532 ----AGLSLAPLNL--------------GDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEF-RDDLDEQIRHMLFSWAERQ-AGQPGAVGLLVQALEQSDRQDVAEEV B_taurus_ENSBTAP00000026157 ----PGLSLAPLNL--------------GDAETGFLTQSNLLNVAGRLGPDWPAVALHLGLPYRELQRIRHEF-RDDLDGQIRHMLFSWAERQ-AGQPGAVGRLVQALEQSDRRDVAEEV C_familiaris_ENSCAFP00000013991 ----PGLSLAPLNL--------------GDAETGFLTQSNLLTVAGRLGPDWPAVALHLGLPYRELQRIRHEF-RDDLDGQIRHMLFSWAERQ-AGQPGAVGLLLRALEQSDRLDVAEEV M_musculus_ENSMUSP00000026580 ----TDFSLMPLNL--------------GDAETGFLTQSNLLSVASRLGPDWPAVALHLGMPYHKLQRIRHEF-RDDLDGQVRHMLFSWAERQ-TGQPGAVGHLVQALEQSDRRDVAEEV G_gorilla_ENSGGOP00000010514 ----AGLSLAPLNL--------------GDAETGFLTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEF-RDDLDEQIRHMLFSWAERQ-AGQPGAVGLLVQALEQSDRQDVAEEV R_norvegicus_ENSRNOP00000025291 ----TDFSLMPLNL--------------GDAETGFLTQSNLLSVASRLGSDWPTVALHLGMPYRKLQRIRHEF-RDDLDGQIRHMLFSWAESQ-TGQPGAVGHLVQALEQSDRQDVAEEV G_gallus_ENSGALP00000022986 ----NGFSFPPLNL--------------GNAETGYLTQANLLSIARRVGADWQTIGLNLGLTYRQIERIGYNN-REDLDKQILDMLFSWAQQN-SGDPDCVSKLITAMKESGRQDIADEV T_guttata_ENSTGUP00000010130 ----YGFSFPPLNL--------------GNAETGYLTQANLLSIARRVGADWQSIGLNLGLTYQQIERIGYNN-REDLNKQILDMLFSWAQQN-SEDPDCVSKLITALKESGRQDIADEV A_carolinensis_ENSACAP00000015049 ----NGFSLPPLNL--------------GNAETGYLTQSNLLGIAGRIGADWQTIGLHLGLSYQQIQRIQYNN-REDLNTQILDMLFSWAQQN-EKKPDCVDQLICAMKESDRQDIADEI T_rubripes_ENSTRUP00000017044 ----ENSQHPPLNL--------------GDPESGYLTESNLLSISLQIGQDWRVVGINLGLSYEELDRIQYKS-RDNLGALVLDMLFHWARGQRRAGPGAVSRLVSAMIESGRRDLADEI G_aculeatus_ENSGACP00000007286 ----EELQHPPLNL--------------GDPESGYLTEANLLSISLQIGQDWRLIGINLGLSYQELDRIQYKH-RDNLGALVLDMLFHWARGQ--TNTGAASRLAAAMIQSGRRDLAEEI T_nigroviridis_ENSTNIP00000019169 ----GDRQHPPLNL--------------GDPESGYLTESNLLSISLQIGHDWQVIGINLGLSYQELDRIKYKN-RDNLGALVLDMLFHWARGQRTAGPGAVSRLVTAMMESGRRDLADEI O_latipes_ENSORLP00000007907 ----DEQQYPPLNL--------------GDPESGYLTEANLLSISLQIGQDWRVIGINLGLSYQELERIEYKH-SKNLGALVLHMLFHWAHRQKSAGPGAVSRLTAAMIESGRRDLAEEI M_domestica_ENSMODP00000018737 ----KGLTLASLNL--------------GDAESGFLTQSNLVTVARRLGPDWQSVALHLGLSYPEVQRIQYAH-RDDLDGQVRNMLFSWAERQ-IGHPGSIQQLLEALEQSDRRDVAEEV O_anatinus_ENSOANP00000020641 ----RRQSFASLALR--------------PQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVEN-PNSLIAQSFMLLKKWVTRD--GKNATTDALTSVLTKINRIDIVTLL A_gambiae_AGAP009937-PA VLNSEQQAVVAAANRGKTLNFTFQ--NGDGGSEIHKADIKITDICNLLGSDWPLLADELAITPSDVELIRAEY-PNDEPQQAIVMLRLWLRQA--GRDATGNVLEQALIKINRPDIVNK- T_guttata_ENSTGUP00000005529 ----RRRTLTPLSLRERYSILSET--SFGSLSSTDKADQKMVDIAEQLGLSWAELARELQFGVDDINRIRVEN-PNSLLEQSIALLNLWASRE--GKNFKIENLYTALRNIDRSEIVNML A_aegypti_AAEL013466-PA ILNYDQQAIVNAANRSKTLNFTFQ--NGDAGSEIHKADIKITDICNLLGSDWPLLAEELQISPSDVDLIKAEY-ENDEAQQAVVMLRLWLRQA--GKDATGNVLEQALIKINRADIVSK- O_latipes_ENSORLP00000008143 ----RRRTLTPLALRERYNALNEP--AMASMSAMERTELKMAVIAEQLGLSWAELARELQLSVDDINKIRVEN-PNSLLEQSSALLNLWATRE--GKRAKMESLYTALKSIDRMDIINML E_caballus_ENSECAP00000009629 ----RRQSFASLALRKRYSYLTEP--GMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVEN-PNSLISQSFMLLKKWVTRD--GKNATTDALTSVLTKINRIDIVTLL P_pygmaeus_ENSPPYP00000020798 ----RRRTPTPLAL--RYSILSES--TPGFLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN-PNSLLEQSVALLNLWVIRE--GQNAKMENLCTALQSIDRGEIVNML A_carolinensis_ENSACAP00000001474 ----RRQNFVSLALRKRYSYLTEP--GMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVEN-PNSLIAQSFMLLKKWVIRD--GKNATTDALTSVLTKINRIDIVTLL D_rerio_ENSDARP00000077097 ----RRRTLTPLALRERYSALNEP--AMASLSAMERTELKMALIAEQLGLSWAELGRELQFNVDEINKIRVEN-PNSLLEQSSTLLNLWAARE--GKRAKMDSLYVALKSIDRVDIVNMM G_gorilla_ENSGGOP00000011462 ----KRRTPTPLAL--RYSILSES--TPGFPSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVEN-PNSLLEQSVALLNLWVIRE--GQNAKMENLYTALQSIDRGEIVNML D_melanogaster_FBpp0088239 LNHNENIVFGVKEQQVKKIDITKACIMSSDIKLIHEADVILDDICSHLGSDWPLLANVLGVSQADIDLVKTEFLLNDSVKQSMAMLQLWLEHG--GI-LTGNVLAEALYKIGRSDIVEK- M_mulatta_ENSMMUP00000032129 ----RRRTPTPLAL--RYSILSES--TPGLLSGTDQAE-KMAVISEHLGLSWAELARELQFSVEDINRIRVEN-PNSLLEQSVALLNLWVIRE--GQNTDMENLCTALQSIDRGEIVNML 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 RAVL-----------------ELGRRKYQ---DSIRRMGL-APKDPALPGSSAPQPPEPAQA---------------------------------------------------------- M_mulatta_ENSMMUP00000021972 RAVL-----------------ELGCRKYQ---DGIRRTGL-APKDPALPGSSAPQPPEPAQA---------------------------------------------------------- P_pygmaeus_ENSPPYP00000003356 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005532 RTVL-----------------ELGRRKYQ---DGIRRTGL-APKDAALPGSSAPQPPEPAQA---------------------------------------------------------- B_taurus_ENSBTAP00000026157 RAVL-----------------ELGRRKYQ---EGIRHTSL-APGNLTSPDRLPSPSPEPAQA---------------------------------------------------------- C_familiaris_ENSCAFP00000013991 RAIL-----------------ELGRQKYK---DSIQRTSL-APRGLDPADPAAPQSVESAQA---------------------------------------------------------- M_musculus_ENSMUSP00000026580 RAIL-----------------ELGRHKYQ---DSIRRTGL-APEDSTLPGTSASQTPESAQA---------------------------------------------------------- G_gorilla_ENSGGOP00000010514 RAVL-----------------ELGRRKYQ---DGIRRTGL-APKDPALPGSSAPQPPEPAQA---------------------------------------------------------- R_norvegicus_ENSRNOP00000025291 RAIL-----------------ELGRHKYQ---DSIRRTGL-APEDSTLPSTSALQNPESAQA---------------------------------------------------------- G_gallus_ENSGALP00000022986 EAII-----------------ELGRRKYR---ESIRRVGL-------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010130 EAII-----------------ELGRQKYS---ESIRRLGL-EQESST------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015049 VAII-----------------ALGKQKYR---ESIRRVGL-DQESST------------------------------------------------------------------------- T_rubripes_ENSTRUP00000017044 EDTV-----------------RIGRRKYS---ESLKRVGL-EEESSTLSEGTAVGAPMPGPD---------------------------------------------------------- G_aculeatus_ENSGACP00000007286 EDIV-----------------SIGRRKYS---DSLRRVGL-EEGGE-----ARVDEPTPAAD---------------------------------------------------------- T_nigroviridis_ENSTNIP00000019169 EDTV-----------------RIGRRKYS---ESLRRLGR-SQRFPLLPPGGARVPNVPPPRPC-------------------------------------------------------- O_latipes_ENSORLP00000007907 EDIV-----------------NIGRRKYS---ESLRRVGL-EAEGS-------------------------------------------------------------------------- M_domestica_ENSMODP00000018737 QAIL-----------------ELGRSKYR---ESIRRVGL-AAEE--------------------------------------------------------------------------- O_anatinus_ENSOANP00000020641 EGPIFDYGNISGTR-------SFADENNGFH-DTVDGYAT-LQTEMETPTGLHNTPPTPFQQDDFFSDISSIESPVRTPSRLSDGLVTSQGNMNFTTEGPPVVKAEDTSLEDSKLDFLM- A_gambiae_AGAP009937-PA ---------------------SITNLEPVTD-EYERRV---AQRQIGSMNGLDE------------------------------------------------------------------ T_guttata_ENSTGUP00000005529 EGSGRQSRSLKGSW-------RYTDRDYSLSPSQMNGYAS-LQDELLSPASLHYTLPSPLRADQYWNEVAIMDAIPMAATEQDALMEMSDMQVWSSGLTPSLVTAEDSSLECSKAEDSD- A_aegypti_AAEL013466-PA ---------------------SITNMELVTD-EREKKL---AKQQLGSTNGIDEVDPVKINGVQSYAMEDSTHEPAEEKQEHETDEKTSKEPSTSSSAASSPDNTEAIQQIRRESAILG- O_latipes_ENSORLP00000008143 EGPPAQP---ERQGSRDFSR-RCHGREH-LSPGMTNGYGL-GQEELLSPASMQYSLPSPLEAEPYWQEVSSLDCAPIATTEEDTLMEMSDVQVWPSGNSPSLVPVEDSSLECSNADDSEG E_caballus_ENSECAP00000009629 EGPIFDYGNISGTR-------SFADENNVFH-DPVDGYPS-LQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDTSLEDSKLEDSM- P_pygmaeus_ENSPPYP00000020798 EGSGRQSRNLKPDR-------RHTDRDYSLSPSQMNGYSS-LQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD- A_carolinensis_ENSACAP00000001474 EGPIFDYGNITGTR-------SFADENNVFH-DPVDGYPM-IQMELETPTGLRYVPPTHSHQDDFCSDFSSIESPLRTPSRLSDVLVTSQGNVDDTAKGPPVVIEEDTSLEDGKQQFSV- D_rerio_ENSDARP00000077097 EGQGGPPAGQQGGWEQDASRSRHHDRDH-LSPGITNGYGLVVQEELVSPASMQYSLPSPLGNEPYWQEVSSMECAPIATTEEDTLMEMSEVQVWPSGNSPSIVAVEDSSLECSNADDSE- G_gorilla_ENSGGOP00000011462 EGSGRQSRNLKPDR-------RHTDRDYSLSPSQMNGYSS-LQDELLSPASLGRALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD- D_melanogaster_FBpp0088239 ---------------------SFKNAEFGTH-QPEKVLPT---------AGIEK------------------------------------------------------------------ M_mulatta_ENSMMUP00000032129 EGSGRQSRNLKPDR-------RHTDRDYSLSPSQMNGYSS-LQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSD- 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021972 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003356 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005532 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026157 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000013991 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026580 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010514 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025291 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000022986 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010130 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015049 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017044 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007286 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000007907 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020641 ----P---VARVYEASERDEKCLVEDVNLRKYPQYIGCLSGEPKDGNHLKPKGIEKSRKVGVSFEQLERGKSGVDEEMTEEKFKSLFEDIHLEEGMEAEEMT--EEKVQAILKHVQQAEQ A_gambiae_AGAP009937-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005529 ----ATS-EGRFPGQLLADA----------------------------------HGPDHM-GSMDLVE------DDTVDSDAMNGMIDLLEQEEGQRPEGKMPSGTGE-------QDPES A_aegypti_AAEL013466-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008143 LLGLPRGSLGRPASQASAAS----------------------------------GGGGILSGSIELPE------DDSEGSEASSELSAVTNTTGGEGA------GGGGGREGGAGS--EE E_caballus_ENSECAP00000009629 ----P---LTEMPEAVDVDE----------------------------------------------------------------SQLENVYL---------------------------- P_pygmaeus_ENSPPYP00000020798 ----ATGHEWKLEGALLEEP----------------------------------RGPEL--GSLELVE------DDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSEN A_carolinensis_ENSACAP00000001474 ----PRKRISKDPGQIQVEE------MDLTDYPQYLGSYAGIPKQMQ------CEETSPTLVRTEQHEREKSGTDEEMTEEKLKSLFEDIHLDEIVESEEMT--EEKVLSILKYVKQAEQ D_rerio_ENSDARP00000077097 --ALQNRSLGHSRSGTPGGN---------------------------------GLTPGGLSGSIELLE------DQSIGAD--SDYSAAVTNNIKDGS------NGGLGEGGGDGTQLED G_gorilla_ENSGGOP00000011462 ----ATGHEWKLEGALSEEP----------------------------------RGPEL--GSLELVE------DDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSEN D_melanogaster_FBpp0088239 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000032129 ----ATGHEWKLEGALSEEP----------------------------------RGPEL--GSLELVE------DDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSEN 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021972 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003356 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005532 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026157 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000013991 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026580 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010514 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025291 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000022986 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010130 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015049 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017044 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007286 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000007907 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020641 EMSSITGWQNEASSDNTESPPPLGCKMIGGILERLDDSPDQCRESITSYLKGEVGKFEANGNHSEGTPEGKTKSHVTDSQNDVGKQKDRETLKPKTQGPIRVEEQTLSLAAYQKSVEEMG A_gambiae_AGAP009937-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005529 EVSFVSVQEKVQA--------------------RIMTSP--------TF-SHDVEKSA--DRLRDWNAEGSFISCLQDLT--AGSWQEGVTRRLLPTHSTASGAQG------QEQ-EQVL A_aegypti_AAEL013466-PA -----------------------------------------------------IASEKKDGDLATPPPSPAEYAFPAAAQQQPAAVSQQVPVDDVEQQGK-------------------- O_latipes_ENSORLP00000008143 GLSLVAGQQRVYA--------------------RLSESP--------GL-SCVADRNGDSDPTQAWVGIQSKSRHVMDTM--ISSVHNSVDGDP----SHVSQEALLQPVRDMGH-SEIL E_caballus_ENSECAP00000009629 ------SWQNETSSGNVESPAQ-ARRIIGGLLDRMDDSPDQCRDSITSYLKGESGKFEANGSHVELTPEAKTKSYFPESQNDVGKQSAKETLKPKIHGSGRVEEPASSLAAYQKSLEETS P_pygmaeus_ENSPPYP00000020798 EVSLVSGHQRGQA--------------------RITHSP--------TV--SRVTERSQ-DRLQDWDADGSIVSYLQDAA--QGSWREEVTQGPHSFQGTSTTTEGLEPSGSQEY-KKVL A_carolinensis_ENSACAP00000001474 ELSSITGWQSEASSVNVEPPIP-GRRISGDLLDQLDESPAQCRDSITSYLKGEAGKLETNGSYSESATAVKTKSFAQESANGLRKQSEKETVKPKMQSALRTEQ---HMISHQKSLQESS D_rerio_ENSDARP00000077097 SISLISGQQRVYA--------------------RMSESP--------GL-RRRADPGEDSDSEQIGVFAMSLPRQAIESM--MSSVRATVDSDS--KQSCLGQEALIEPVRDMGH-SEII G_gorilla_ENSGGOP00000011462 EVSLVSGHQRGQA--------------------RITHSP--------TV--SQVTERSQ-DRLQDWDADGSIVSYLQDAA--QDSWREEVTQGPHSFQGTSTTTEGLEPGGSQEY-EKVL D_melanogaster_FBpp0088239 -----------------------------------------------------------DGDYEQ------------------------------------------------------- M_mulatta_ENSMMUP00000032129 EVSLVSGHQRGQA--------------------RLYHSP--------TA-RDQVSKRSETDGLQDWDPDGSIVSYLQDAA--QGSWREEVTQDPHLFQRTSTTTEGLEPSGSQES-ENVL 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000337797 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021972 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000003356 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005532 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000026157 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000013991 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026580 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000010514 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025291 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000022986 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000010130 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015049 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017044 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007286 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000019169 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000007907 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000018737 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000020641 KPATEEPKTSVP----VSGKKMNRTSPGDGKPRLTLQGEEGAGISDHKVKSPGATLSRMAGCCSKEFKGSESDSTSDEERRVTTRVIRRRLIIKGAEAKNMPGESVTEEQFTDEEGNIIT A_gambiae_AGAP009937-PA ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000005529 LCRGQRLAASAP------------------HRRLAGGGQQPLLWAGES----------------------------------------ALQEVQGKEDIHLPGEQVTEQQFTD-QGNIVT A_aegypti_AAEL013466-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000008143 ---RGQFRGTQPFEKGLGFPHRVPELRAWDDEN-SFQLEQ-----------------------------------------------------EGDEVEDLPGEQVSEEQFTDEHGNIVT E_caballus_ENSECAP00000009629 KFVIEEPKPCVP----VSVKKMSRTSPADGKPRLNLHEEEGSSGSEQK------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020798 VSVSEHTRTEQP---------EAESFQADRDWRQQGQEEE-VQEAKNT----------------------------------------FTEVMQGNEFQNIPGEQVTEEQFTDEQGNIVT A_carolinensis_ENSACAP00000001474 KPAVDAPKTSVP----VSMKKTSGNTSNDSKMRLKAEEEAGATASEPK------------------------------------------------------------------------ D_rerio_ENSDARP00000077097 ---HGHYQGTQPFEKGLGFPHRTTNMRTWEDMRLSGQVRR-----------------------------------------------------DGDEAEDLPGEQVSEEQFTDEHGNIVT G_gorilla_ENSGGOP00000011462 VSVSEHTRTEQP---------EAESSQADRDRRQQGQEEQ-VQEAKNT----------------------------------------FTQVVQGDEFQNIPGEQVTEEQFTDEQGNIVT D_melanogaster_FBpp0088239 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000032129 VSVSEHTRTEQP---------EAESSQADRDQRQQGQGEQ-VQEARNT----------------------------------------FTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVT 2170 2180 2190 2200 2210 2220 2230 2240 =========+=========+=========+=========+=========+=========+=========+=========+====== H_sapiens_ENSP00000337797 -------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021972 -------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000003356 -------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000005532 -------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000026157 -------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000013991 -------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000026580 -------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000010514 -------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000025291 -------------------------------------------------------------------------------------- G_gallus_ENSGALP00000022986 -------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000010130 -------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015049 -------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000017044 -------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000007286 -------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000019169 -------------------------------------------------------------------------------------- O_latipes_ENSORLP00000007907 -------------------------------------------------------------------------------------- M_domestica_ENSMODP00000018737 -------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000020641 RKVTRKVIRRIAIPHERKLGD-----MQGE-------------------------------------GYKVKTKKEIRHVEKKSY- A_gambiae_AGAP009937-PA -------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000005529 KKIIRKVVRQLGPGDMGDRQEQEELILEGS----QDLEAEDDHFMKYSILHRDVRVPKPEVSGGRM-GAQIVKRASLKRGKQ---- A_aegypti_AAEL013466-PA -------------------------------------------------------------------------------------- O_latipes_ENSORLP00000008143 KKIVRKVVRRGKGSGEEGVQEHDNIFLKGQ----------------------------SDSVDVKK-GAQIVKCASLRRVKQ---- E_caballus_ENSECAP00000009629 ---------------------------QGE-------------------------------------GYKVKTKKEIRQVEKKSHS P_pygmaeus_ENSPPYP00000020798 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDSFMKHSKVELRGSGLQPDLIEGRK-GAQIVKRASLKRGKQ---- A_carolinensis_ENSACAP00000001474 ----------------------------GE-------------------------------------GYKLKTKKEVRHMEKTTY- D_rerio_ENSDARP00000077097 KKIVRKVVRRGK--GEEGGQERSGRLSLLQ----------------------------PDVVDVKRGGAQIVKCASLRRVKQ---- G_gorilla_ENSGGOP00000011462 KKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDSFMKHSKVELRGSGLQPDLIEGRK-GAQIVKRASLKRGKQ---- D_melanogaster_FBpp0088239 -------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000032129 KKIIRKVVRQIDLSSADAAQEHEEDHTSTP--NP----------------------------------------------------