>H_sapiens_ENSP00000269280 ------------------------------------------------------------ ------------------------MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHS-- ------RSSSGETPAQPEKTSGMEV-ASYLVAQYGE-QRAWDLALHTW-----EQMGLRS LCAQAQEGAGHSP--SFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ -----LPDTSGRRWREISASLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQP SLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGR----PPWAAVVGTPPQAHTSL ----QPHHHPWEPSVRESLCS--TWPWKNEDFNQKFTQLLLLQRP---HPRSQDPLVKRS WPDYVEENRGHLIEIRDLFGPGLDTQE-PRI--VILQGAAGIGKSTLAR-QVKEAWGRGQ LYGDRFQHVFYFSCRELAQ-SKVVS--LAELIGKD--GTATPAPIRQILSR-PERLLFIL DGVDEPGWV------LQ--EPSS----ELCLHWSQPQPADALLGSLLGKTILPEASFLIT ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDER---------QAIRAFRLVK SNKELWALCLVPWVSWLACTCLM-----QQMKRK-EKLTL--TSKTTTTLCLHYLAQAL- ----------------QAQPLGPQLRDLCSLAAEGIW-QKKTLFSPDDLRKHGLDGAI-I STF--LKMGILQEHP---IPLSYSFIHL-CFQEFFAAMSYVLEDEKGRG----------- --------------------------KHSNCI--IDLEKTLEAYGIH-GLFGASTTRFLL GLLSDEGEREMENIFHCRLSQ--GR---NLMQWV-------------------------- -------PSLQLLL-Q-PHSLESLHCLYET-RNKTFLTQVMAHFEEM------------- -----GM-CVE-TDMELLVCT-----FC-IKFSRHVKKLQLIEG-R--QHRSTWSPTM-- -----------VVL-FRWVPVT-DAYWQILFSVLK-VTRN--LKELDLSGNSLSHSAVKS L------CKTLRRP------RCLLETL--------------------------------- ------------------------------------------------------------ ---RL-AGCGLTAEDC--KDLAFGLRAN-QTL-TELDLS-FNVLTDAGAKHLCQRLR--Q -PSCKLQRLQ-------------------------------------------------- -----------LVSCGLTSDC----CQDLASVLSASPS-LKEL----------------- --------------------------------------------DLQQNNLDDVGVRLLC EGLRHPACKLIRL----------------------------------------------- ---------GLDQTTLSDEMRQELRALEQEK-PQLLIFSRRKPSVMTPTEGLDTGEMSNS TSSLKRQRLGSERAASHVAQANLKLLDVS----KIFPIAEIAEESSPEVVP--VELLCVP SPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMR EAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTS LFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHR VHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGML EILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG--DLMPA TTLIPPARI--------AV-PSPLDAPQLLHFVDQYREQL--IARVTSVEVV-LDKLHGQ VLSQEQYERVLAENTRPSQMRKLFS----L-SQSWDRKCKDGLYQALKETHPHLIMEL-- WEKGSKKGLLPLSS---------------------------------------- >P_troglodytes_ENSPTRP00000014740 ------------------------------------------------------------ ------------------------MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHS-- ------RSSSGETPAQPEKTSGMEV-ASYLVAQYGE-QRAWDLALHTW-----EQMGLRS LCTQAQEGAGHSP--SFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ -----LPDTSGRRWREISASLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQP SLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGR----PPWAAVVGTPPQAHASL ----QPHHHPWEPSVRESLCS--TWPWKNEDLNQKFTQLLLLQRP---HPRSQDPLVKRS WPDYVEENRGHLIEIRDLFGPGLDTQE-PRV--VILQGAAGIGKSTLAR-QVKEAWGRGQ LYGDRFQHVFYFSCRELAQ-SKVVS--LAELIGKD--GTATPAPIRQILSR-PERLLFIL DGVDEPGWV------LQ--EPSS----ELCLHWSQPQPADALLGSLLGKTILPEASFLIT ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYKYFTDER---------QAIRAFRLVK SNKELWALCLVPWVSWLACTCLM-----QQMKQK-EKLTL--TSKTTTTLCLHYLAQAL- ----------------QAQPLGPQLRDLCSLAAEGIW-QKKTLFSPDDLRKHGLDGAI-I STL--LKMGILQEHP---IPLSYSFIHL-CFQEFFAAMSYVLEDKKGRG----------- --------------------------KHSNCI--IDLEKMLEAYGIH-GLFGASTTRFLL GLLSDEGEREMENIFHCRLSQ--GR---NLMQWV-------------------------- -------PSLQLLL-Q-PHSLESLHCLYET-RNKTFLTQVMAHFEEM------------- -----GM-CVE-TDMELLVCT-----FC-IKFSHHVKKLQLIEG-R--QHRSTWSPTM-- -----------VVL-FRWVPVT-DAYWQILFSVLK-VTRN--LKELDLSGNLLSHSAVKS L------CKTLRRP------RCLLETL--------------------------------- ------------------------------------------------------------ ---RL-AGCGLRAEDC--KDLAFGLRAN-QAL-TELDLS-FNVLTDAGAKHLCQRLR--Q -PSCKLQRLQ-------------------------------------------------- -----------LVSCGLTSDC----CQDLASVLSASPS-LKEL----------------- --------------------------------------------DLQQNNLDDVGVRLLC EGLRHPACKLIHL----------------------------------------------- ---------GLDQMTLSDEMRQELRALEQEK-PQLLIFSR-------------------- ------------RAASHVAQANLKLLDVS----KIFPIAEIAEESSPEVVP--VELLCVP SPASQGDLHMKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVVR EAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTS LFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHR LHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGML EILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG--DLMPA TTLVPPARL--------AV-PSPLDAPQLLHFVDQYREQL--IARVTSVEVV-LDKLHGQ VLSQEQYERVLAENTRPSQMRKLFS----L-SQSWDRKCKDRLYQALKETHPHLIMEL-- WEKGSKKGLLPLSS---------------------------------------- >P_pygmaeus_ENSPPYP00000008863 ------------------------------------------------------------ ------------------------MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHS-- ------RSSSGETPAQPEKTSGMEV-ASYLVAQYGE-QRAWDLALHTW-----EQMGLRS LCAQAQEGAGHSP--SFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ -----LPDTSGRRWREISSSLLYQ-ALPSSPDYE-SPSQESPNAPTSTAVLGSWGSPPQP SLAPREQEAPGTQWPLDEMSGIYYAEIREREREKSEKGR----PPWAAAVGTPPQAHTSL ----QPHRHPWEPSVRESLCS--TWPWKNEDLNQKFTQLLLLQRP---HPRSQVPLFKGS WPHYVEENRGHLIEIRDLFGPGLDTQE-PRI--VILQGAAGIGKSTLAR-QVKEAWGRGQ LYGERFQHVFYFSCRELAQ-SKVVS--LAELIGKD--WTVTQAPIRQILSM-PERLLFIL DGVDEPGWV------LQ--EPSS----ELCLHWSQPQQADALLGSLLGKTILPEASFLIT ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYKYFTDER---------QAIRAFRLVK SNKELWALCLVPWVSWLACACLM-----QQMKRK-EKLTL--TSKTTTTLCLHYLSQAL- ----------------QAQPLGPQLRDLCSLAAEGIW-QKKTLFSPDDLRKHGLDGAV-I STL--LKMGILQEHP---IPLSYSFIHL-CFQEFFAAMSYALENKKGKG----------- --------------------------KHSNCI--IDLEKLLEAYGTH-GLFGASTTRFLL GLLSDEGEREMENIFHCQLSQ--GR---NLMRWV-------------------------- -------PSLQLLL-Q-PHSLESLHCLYET-RNKTFLTRVMAHFEEM------------- -----GM-CVE-TDMELLVST-----FC-IKFSRHVKKLQLIEG-R--QHRSTWSPTM-- -----------VVL-FRWAPVT-DAYWQILFSVLK-VTRN--LKELDLSGNSLSRSAVKS L------CKTLRCP------RCLLETL--------------------------------- ------------------------------------------------------------ ---RL-AGCGLIAEDC--KDLASGLRAN-WTL-TKLDLS-FNVLTDAGAKHLCQRLR--Q -PSCKLQRLQ-------------------------------------------------- -----------LVSCGVTSDC----CQDLASVLSASPI-LKEL----------------- --------------------------------------------DLQQNNLDDAGVRLLC EGLRHPACKLIRL----------------------------------------------- ---------GLDQTTLSDEMRQELRALEQEK-PQLLIFSRRKPSVMTPIEGLDTGETSNS TSSLKRQRLRSETEPSHIAQADLKRLDWSNPPAKASQSAGITEGSSPEVAQ--VEPLCLP SPASQGDLHTKALGTDDDFWGPTGPVAAEIVDKEKSLYRVHFPVAGSYRWPNMGLCFVVR EAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTS LFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFLPVTSVVLLYHR LHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGML EILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPG--DLMPA TALVPPACI--------AV-PSPLDAPRLLHFVDQYREQL--IARVTSVEVV-LDKLHGQ VLSQEQYERVLAEDTRPSQMRKLFS----L-SQSWDRRCKDRLYQALKETHPHLIMEL-- WEKGSKKGLLPLSS---------------------------------------- >G_gorilla_ENSGGOP00000011186 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------ISASLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQP SLAPREQEAPGTQWPLDETSGIYYTEIRERERXKSEKGR----PPWAAVVGTPPQAHASL ----QPHHHPWEPSVRESLCS--TWPWKNEDLNQKFTQLLLLQRP---HPRSQDPLVKRS WPDYVEENRGHLIEIRDLFGPVLDTQE-PRV--VILQGAAGTGKSTLAM-QVKEAWGRGQ LYGDRFQHVFYFSCRELAQ-SKVVS--LAELIGKD--GTATPAPIRQILSR-PERLLFIL DGVDEPGWV------LQ--EPSS----ELCLHWSQPQPADALLGSLLGKTILPEASFLIT ARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYKYFTDER---------QAIRAFRLVK SNKELWALCLVPWVSWLACTCLM-----QQMKRK-EKLTL--TSKTTTTLCLHYLSQAL- ----------------QAQPLGPQLRDLCSLAAEGIW-QKKTLFSPDDLRKHGLDGAI-I STL--LKMGILQEHP---IPLSYSFIHL-CFQEFFAAMSYVLEDKKGRG----------- --------------------------KHSNCI--IDLEKMLEAYGIH-GLFGASTTRFLL GLLSDEGEREMENIFHCQLSQ--GR---NLMQWV-------------------------- -------PSLQLLL-Q-PHSLESLHCLYET-RNKTFLTKVMAHFXEM------------- -----GM-CVE-TDMELLVCT-----FC-IKFSRHVKKLQLIEG-R--QHRSTWSPTM-- -----------VVL-FRWVPVT-DAYWQILFSVLK-VTRN--LKELDLSGNSLSHSAVKS L------CKTLRRP------RCLLEIL--------------------------------- ------------------------------------------------------------ ---RL-AGCGLIAQDC--KDLAFGLRAN-QTL-TELDLS-FNVLTDAGAKHLCQRLR--Q -PSCKLQRLQ-------------------------------------------------- -----------LVSCGLTSDC----CQDLASVLSASPS-LKEL----------------- --------------------------------------------XLQQNNLDDVGVRLLC EGLRHPACKLIRL----------------------------------------------- ---------GXXXXXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXRAASHVAQANLKLLDVS----KIFPIAEIAEESSPEVVP--VELLCVP SPASQGDLHTKPLGTDDDFWGXXXXXXXXXXXXXXXXXXVHFPVAGSYRWPNTGLCFVVR EAVTVEIELCVWDQFLGEINPRHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTS LFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHR LHPEEVTFHLYLIPSDCSIRKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKRDETLVWEALVKPG--DLMPA TTLVPPARI--------AV-PSPLDAPRLLHFVDQYREQL--IARVTSVEVV-LDKLHGQ VLSQEQYERVLAENTRPSQMRKLFS----L-SQSWDRKCKDRLYQALKETHPHLIMEL-- WEKGSKKGLLPLSS---------------------------------------- >E_caballus_ENSECAP00000006832 ------------------------------------------------------------ ------------------------MAGGAELQWPWYLESREKKEPKEFQLRLPDAHSR-- -------HSPGETVAQVE-ASGPEV-ASRLVALYGQ-RQAWDLALLTQ-----RRMDLSR VSIQAHREAASIPISSLHASLGKPNLEFSSAPTSTMVLGHWVPEAP-GLLQDSQRKNLRH -----LPGTSGHTWKENPPSFPFQ-DFPYSPVCE-SPSQESPNAPTSTAVLGGWEFPPQS MLACRKQEPPRTAWPLAETSGKHSTVVEGRDRRGHLTGV----PLMAAEPGSEPQAHTEH ----PGLWERYQKQWRETPCP--TQSRQNEDLHQKFVQLLLLHTS---DPGSHESLVRRC CPHGVVEEEGHLIEIGDLFGPGLGTQRGPHT--VVLHGVTGIGKSTLAR-QVRGAWEEGR LYRDRFQHVFYFNCTELAQ-SKPVS--LAKLMGED--CAAPAPP---IRSQ-QEKMLFIL DGLDEPELV------LE--EQRP-----LCEDWSLRQPVPRVLHSLLRKVLLPEASLLVT ARTPAPQKFILSLEHPHWVEVLGFSESSRKEYFYRYFTEES---------QAVQAFSLVE SNPALLTLCLVPFVSWMVCTCLK-----QQMERG-EELSL--TSQTTTALCLHYLSQAL- ----------------PAQPLRTQLRCLCSLAAEGVG-QGETLFSLNDLRKHRLDGAC-I STL--LKMGLLQKHP---TSQRYSFIHP-FFQGFFAAMSYALGDKE-KS----------- --------------------------DHLNST--RRIKKLLEKCERH-DPFGTPTTPFLF GLLSEQGVRKMEHIFRCKLSQ--ERKG-DLLQKV-------------------------- -------RRGHPSL-P-PYSLQVLRCLYEI-QDEDFLTQAMAHFQRT------------- -----RM-YVQ-TDMELLVFT-----FC-VKFCHHVERLQLNES-G--PHRQAWRPSS-- -----------VVL-LSRAPVT-DACWKVLFSVLQ-VTGS--LKELDLSGNFLSLSAVQS L------CEALRHP------RCHLQTL--------------------------------- ------------------------------------------------------------ ---RL-ASCGLTAEGC--KDLASGLSTS-QTL-TELELS-CNVLEDAGVKHLCQGLR--Q -PSCVLQRLL-------------------------------------------------- -----------LVSCGLTSGF----CQDLASVLSAGSR-LTEL----------------- --------------------------------------------DLQQNKLGDLGVKLLC EGLRRPTCQLMLL----------------------------------------------- ---------WLDQTQLNEEVTEMLRALEKN--AQLLILSRWKPSVTTPNEGRDGGEMSEN RCSLKRQRAESARAQSPKAHSGLLSLELT-------TALPVPESSSPQVVQ--VQPLFLP FPASPGDPHVEPLETKDDFWGPMGPVATEVVDKERSLYRVHLPMAGSYRWPNTGLHFVVR GPVTIEIEFCAWGQFLDRTVPQHSWMVVGPLFDIKAEPGAVAAVYLPHFVVLQGAHVDIS LFQVAHFKEEGMLLEKPARVEPCYAVLENPSFSPVGVLLRMIHAALPFIPVTSTVLLYYH FQPEEVTFHLYLIPNDCTIRKAIDDEEKKFQFVRIHKPPPLTPLYVGSRYTVSGSKK--L EIIPKELELCYRSPGESQLFSEFYIDHFGTGIKLQMRDKKDGTVVWEALVKRG--KVETK AVVKPSCLL--------AVSPSHGLAPASLHFVDRYREQL--VARVTSVDPV-LDKLHGL VLSEEQYEKVRAEATTPSQMRKLFS----F-SKSWDWACKDKFYQALKETHPHLIVEL-- WEK--------------------------------------------------- >C_familiaris_ENSCAFP00000022816 ------------------------------------------------------------ ------------------------MACRVQWQLAWYLEMMGKEELKEFQLRLLEQQFW-- ------GDPPHALRAQLGKARGLEV-ASRLVAQYGE-QQAWVLALRTW-----EEMGLSR LCAQSRAEAGLIP--LSPGSPMAPSMQSPNSPISTEVLRF---------IQDPRTRNSGQ PLPPLLPNTSGHMWNEDPSSCKYQEGLPDSPEFQGSPHQESPSAPMPTAVLGGWEAPPQP SPVPGKQEAPKAGWPVAGTSGNHNPGERNRSQTESPQGR---SVPYLYVPSFPPLAGIT- --------ERYQHQRRKKPYP--TWSWEDKDLHQIFIQLLLLHQP---YPRGHESLTKGR WHHG-AEKQGHLIEVEDLFGPGLGAQEEPQT--VILHGVAGIGKSTLAR-QIRTAWKEGQ LYKDRFRHVFYFNCRELAR-SETMS--LTELITKA--QAGPVLPAEQILSQ-PGRLLFIL DDLDEPRWV------LG--EQES----ELHSSWSKQRPVHALLGSLLGKTVLPEVSLLVT VRTTALRRLVPSVGQLCWVEVLGFSESGRREYFYKYFKNKS---------QATQAFSLVE LNPTLLTMCLVPLVSWLLCTCLK-----KQMQRG-EELSL-GSSQTTTALWLYYLSQAL- ----------------PAQLLGAQLRGFCSLAAEGFW-QGTNLLSRRDLRKHGFDEAT-I STF--LKTGILRKHP---SPLNYHLAHR-CLQEFFAAVSCVLGGEDGGS----------- --------------------------PHPDSI--RGAEKLLEVYEGH-DLFGAPTTHFLF GLLSEQGEREMEAVFQCKLPR--ERKR-DLLRWA--EAG--------------------- -----LWPRLS-AP-Q-PCSLHLLHCLYEI-QDEDLLTRAMAHFHGR------------- -----SM-CVQ-TGVEFLVCT-----FC-FKFCSHVKRLQLNES-R--WDGQAWRPSS-- -----------VAL-FSWVPVT-DACWQALFSTLR-ASGS--LKELDLSGNHLSHPAVQS L------CKVLKFP------CCHLETV--------------------------------- ------------------------------------------------------------ ---RL-AGCGLTAEGC--SDLASALSAS-PAL-AELELS-FNLLLDAGAQHLSRGLR--Q -PACRLRRLL-------------------------------------------------- -----------LAGCSLTSRC----CGALASALSTSPL-LTEL----------------- --------------------------------------------DLQQNELGDVGVRLLC GGLGHPTCQLTLL----------------------------------------------- ---------WLDQTQLSEEMTQMLRALQEEK-PQLFVCSKWKPRATVPTEGLSRGETSGT -SSLKQQRQGSGRKSNAVAQARQPSLDRE--SGADSCSAPFPERSCPQVGQ--VQLGRPP SPAAPWDLNTEPLRIGDGFWGPLGPVAPEWLAEDGSLYRVHLPVAGSYHWPDTGLRFEVR GPATIDIEFCVWDQHLPRAGLWHSWMVAGPLFDIKAEPGAVATVCLPHFVDLQGSSVDTS LFYAAHLKDEGMLVETPARVEADHVVLENPSFSPIGVLLRTIHAALRFLPVTCVVLLYHH LRPGEVAFHLYLIPSDYSIRKAIDNEEKKFQFVQIHKPPPLASLYMGSRYTVSGSEK--L EIIPKELELCYRSPREPQLFSEFYVSHLGSGIRLQVRDKKDDTVVWEALVKPG--DLRPV ASLAPPAPA--------AR-PFPTDAPAWLHFVDRHREQL--VARVTSVDPV-LDMLHGQ VLSEEQYERVRAEATTPSQMRKLFS----F-SRSWDRACKDQVYQALKEAHPHLIMEL-- WEKWGGNSGKQAPPG--------------------------------------- >B_taurus_ENSBTAP00000027232 ------------------------------------------------------------ ------------------------MAGEA--RSLEDLEEKKKQKLKELRLWLPDEEPR-- ------LQSPEVVHAQPEKPRSRKT-MTILSVMKEV-QHEC-MAIHTKGPHVNEQGACTK TLEETDLNSALYS--SFSHSPSAPNLESPSWPTSTKVLTFCKPKQP---VLNPLKWSSSP -----LIFASGYRKEDLSPSI-YQ-GFPSSPYHE-SPSQELPNDPTSTAVLRACEIPRHS CPEPREKEGPGTVWPLVETSGNSCTEVDTVENINSQNGRDGIQPPLSLMPLLPPSTHLMF CFPCHRSRQRYQDQRRETPCS--TWSWKNEDLHPKFMQLLLLHTP---YHKDYESLNRES WDHGVVEGQGHLIEVRDLFGSDLGSQEGPHT--VILHGVAGIGKSTLAR-HIRRAWEEGQ LYRNHFQHVFYFNCRELAT-SKLTS--LEELITKD--QSTTVAPAGQIQSQ-PEQLLFIL DGLDELECV------SE--EKRA----ELCLHRSQQQSVQTLLGSLVEKTIFPEASLLIT ARTAALQKFIPSLKQPCWVEVLGFSESSRKDYFYEYFTEES---------QATRAFSVVE SNQALLTMCLTPLVSWLACTCLK-----QQMEAG-EELSL--KSQTMTALYLRYLAQAI- ----------------QAQPLGTQLRGFCTLAAEGIC-QGKTLFSPGDLKKHGLDGVI-S ATP--LKMDVLQKHP---TSLNYSFIHL-CFQEFFAAVSFALGDIRDKS----------- --------------------------DHPNST--GSMEKLVEVYGIN-NLFGAPTVHFLS GLLSEQGAREMENIFQCKLSW--ERKRESLLRWA-------------------------- --------ELELRR-E-HYSLQLFHCLYEI-QDEEFLTQAMAHFQGM------------- -----RV-CIR-TSMELLVFT-----FC-IRFCSHVWRLQLNEG-R--QHPGACRPTD-- -----------TVL-LSWVPAT-EACWQVLCSVLQ-VTGN--LKELDLSRNILSRSAVQS L------DEALRCP------GCQLETL--------------------------------- ------------------------------------------------------------ ---RL-ASCSLTAESC--KDIASGLSTS-QTL-MQLELS-FNTLLDAGAEHLCQGLR--Q -PTCKLQRLL-------------------------------------------------- -----------LAGCGLTSGC----CQDLASMLRVSPS-LMEL----------------- --------------------------------------------NLLQNDLDDLGVRLLC EGLRHPSCQLICL----------------------------------------------- ---------WLDQTQLSEEVTKMLRALERQK-PQLLVSGIWKPSLRILHEGPGGAEMSDT -SSLKRQRQASARQKN---------LKLA----AALS---APEGSSPQAAQ--VRLFCPS SPAPPEDEHMESLGTEDDLWGPTGPVATEAVDEERSLYRVHLPMAGFYHWPNTGLRFEVR GPVTVEIEFCAWDQFLNRNFPQRSWLAAGPLFDIKAEPGAVAAVFLPHFVAFRGNDVDIS QFQVAHFKEEGMLLEKPARVTPCYAVLENPSFSPMGVLLRMVQTALRFIPITSTVLLYHY LQPEEVTFHLYLIPSDCSIQKAIDNEEKMFQFVRIHKPPPLTPLYMGSRYIVSGSEK--L EILPEELELCYRSPRESQLFSEFYVRHLRSGIRLQIRSKKDGTVVWEALVKPG--DLRRA VTPVSPGLR--------AS-PDSPAALRLRHFVDRHREQL--VARVTSVDPI-LDKLHGQ VLSEEQYEGVRAETTAPGQMRRLFG----F-SRSWDWACKDRLYQALKETHPHLIMEL-- WEKWG-SEETRPGS---------------------------------------- >M_musculus_ENSMUSP00000038186 ------------------------------------------------------------ ------------------------M----------------------------------- -----------------EESQSKQE-SSTKVAQHEG-QEDVDPTFKTK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KLMEVELMKHRV-------------QLERNLKL ----RTFPGARTKQVKEALYPLLTWSSKSKNLFQNFTKLLLFKKL---CQRGSENLVRES WYPCVPEEEAHMIDIQDLFGPNLGTQKKPQL--VIIEGAAGIGKSTLAR-LVKRAWKEGK LYRNDFHHVFFFSCRELAQ-YEQLS--LAELIVQG--QEVPTAPIRQILSH-PEKLLFIL DGIDEPAWV------LA--DQNP----ELCLHWSQTQPVHTLLGSLLGKSILPGASFLLT TRTTALQKFIPSLEQPCQVEVLGFTLFERKNYFYKYFGKKK---------GGVTTFTLVK SNSALLTLCEVPWVCWLVCTCLK-----KQMEQG-GELSL--TSQTTTALCLKYLSLTI- ----------------PGQHMRTQLRDLCSLAAEGVC-QRRTLFSESDLCKQGLDEHA-I ASF--LKIGVLQKQA---SSLSYSFAHL-CLQEFFAAMSYILDDSEERH----------- --------------------------ADMKND--RIVETLVERYGRQ-NLFEAPTVRFLF GLLSKEELKKIEKLFSCSLHG--KTKL-KLLWHI-------------------------- ------LGKSQPHQ-P-PC-LGLLHCLYEN-QDMELLTHVMHDLQGTIVPGPDDLAHTVL QTNVKHL-VIQ-TDMDLMVVT-----FC-IKFCCHVRSLQLNRK-V--QQGHKFTAPG-- -----------MVL-YRWTPIT-DASWKIFFSNLK-LARN--LEELDLSGNPLSYYAVHS L------CTTLRKR------GCQLKTL--------------------------------- ------------------------------------------------------------ --------CTLPEDMN--KAEVKNTEAK-GSL-GEKAPG-PRNDIFPFPPAHCPYNQ--T -STSEHLPCR-------------------------------------------------- -----------LVECGLTSTY----CSLLASVLSARSS-LTEL----------------- --------------------------------------------DLQLNDLGDGGVKMLC EGLRNPACNLSIL----------------------------------------------- ---------WLDQASLSDQVIAELRTLEAKN-PKLLISSTWKPHVMVPTMNMDKEEVGDS QALLKQQRQQSGMVGWLLKEDNVKKIKQN----ATNTYAHTHTHTHAELVP--LKTFHPC SPVSPGDKHMEPLGTEDEFWGPTGPVTTEVVDRERNLYRVQLPMAGSYHCPSTGLHFVVT RAVTIEIEFCAWSQYLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVALQEGIVDSS LFHVAHFQEHGMVLETPARVEQHYAVLENPSFSPMGILLRMIPAVGHFIPITSTTLIYYH LYLEDVTFHLYLVPNDCSIRKAIDDEEMKFQFVRINKPPPVDALYLGSRYIVSSSKL--V EIIPKELELCYRSPGESQLFSEIDIGHMDSEIKLQIKDKRHMNLKWEALLKPGKISLRPE TLRVEERDTKGAFLCSFPVSSLSLDAPSLLHFMDQHREQL--VARVTSVDPL-LDKLHGL VLSEDSYEVVRSETTNQDKMRKLFS----L-SRSWSWDCKDQFYQALKETHPHLVMDI-- LEKLGGVSVKS------------------------------------------- >R_norvegicus_ENSRNOP00000034130 ------------------------------------------------------------ ------------------------M----------------------------------- -----------------EESQSKQE-SNTRVAQHGS-QQDVDPTFQTK------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RALEKERSKPRP-------------RPLPRVQL ----QSLPGWKGSQIKNAVSGLQWWSMEQKYLFQNFTKLLLLQKC---CPGGSEKLVRES WHPCVPEEGGHMIEIQDLFDPNLDTEKKPQL--VIIEGAAGIGKSTLAR-QVKRAWDEGQ LYRDRFQHVFFFSCRELAQ-CKQLS--LAELIAQG--QEVPTAPTRQILSR-PEKLLFIL DGIDEPAWV------LE--DQNP----ELCVHWSQAQPVHTLLGSLLGKSILPEASLMLT ARTTALQKLVPSLGQPHRVEVLGFSEFERKDYFYKYFAKER---------NTIIDFNLIG SIPVLLTLCEVPWVCWLLCTCLE-----KQMQQG-EVLSL--TSQTTTALCLKYLSLTI- ----------------PGQHLSTQLRTLCSLAAEGIC-QRRTLFSKSDLCKQGLAEDA-I ATF--LKIGVLQRQP---SSLSYSFAHL-CLQEFFAAMSYILEDSEEAH----------- --------------------------GDMGND--RTVETLVERYGRQ-NLFEAPTVRFLL GLLNTREMREMENIFACKFPW--ETKL-KLLQSI-------------------------- ------IG--EPFC-Q-PCHLGLFHCLYEN-QEEELLTETMLCFPLT-ASGPNHMEATVF QTNVKRL-VIQ-TDMELMVVT-----FC-ITF-SHVRSLRLKGK-G--QQEYKLTAPA-- -----------MVL-YRWTPIS-EASWKVLFSNLK-CTRN--LEELDLSGNPLSYSAVRS L------CTALRQP------GCRLKTL--------------------------------- ------------------------------------------------------------ --------CTYPEDMA--KTEVKNT-GK-GSLRGESSRG-PR-EVLPWPMAAKHWPG--E -TDGEHLPFR-------------------------------------------------- -----------LVDCGLTSRC----CSFLASMLSAHSR-LAEL----------------- --------------------------------------------DLRLNDLGDNGVRQLC EGLRNPACNLSIL----------------------------------------------- ---------RLDQASLSEQVITELRALETKN-PKLFISSTWMSHMTMPTENTDGEESLTS ---SKQQQQQSGMLGWLIK-SNVKKIKQN----LPLSLSLSLSLSLSLSLS--L-TFHPC SPVSPGDKHMEPLGTDDDFWGPSGPVSTEVVDRERNLYRVRLPMAGSYHCPSTGLHFVVT RAVTIEIGFCAWSQFLHETPLQHSHMVAGPLFDIKAEHGAVTAVCLPHFVSLQEGKVDSS LFHVAHFQDHGMVLETPARVEPHFAVLENPSFSPMGVLLRMIPAVGHFIPITSITLIYYR LYLEDITFHLYLVPNDCTIRKAIDEEELKFQFVRINKPPPVDALYVGSRYIVSSSKE--V EILPKELELCYRSPRESQLFSEIYVGNIGSGINLQLTDKKYMNLIWEALLKPGKISLRPE TLRPQERDPKGAFLCSEPV-SLPLDAPALLHFVDQHREQL--VARVTSVDPL-LDKLHGL VLSEEDYETVRAEATNQDKMRKLFR----G-SRSWSWDCKDHFYQALKETHPHLIMDL-- LEKSGGVSVRL------------------------------------------- >M_musculus_ENSMUSP00000104155 ------------------------------------------------------------ ------------------------M----------------------------------- -----------------EESQYKQE-HNKKVAQDEG-QEDKDTIFETI------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EAIEAKLMELKT-------------NPESTFNY ----GIFPEVYMNQGEEILYP--AWSLKEENLFQTFKSLRLFQKL---CPRGSGNLVKKS WYPCVPEEGGHIINIQDLFGPNIGTQKEPQL--VIIEGAAGIGKSTLAR-QVKRAWMEGE LYRDHFQHVFFFSCRELAQ-CKKLS--LAELITQG--QDVPTAPINQILSH-PEKLLFIL DGIDEPAWV------LA--DQNP----ELCLYWSQTQPVHTLLGSLLGKSILPEASFLLT TRTTALQKFIPSLPQSCQVEVLGFSDFEQEIYIYKYFAKQI---------FGIKALMMVE SNPVLLTLCEVPWVCWLVCNCLK-----KQMEQG-GDVSL--TSQTTTAICLKYISLTI- ----------------PVHHMRTQLRALCSLAAEGIW-KRRTLFSESDLCKQGLDEDA-V AIF--LKTGVLQKQA---SSLSYSFAHL-CLQEFFASMSCILEDSEERH----------- --------------------------GDMEMD--RIVETLVERYGRQ-NLFEAPTVRFLF GLLSKEGLKEMEKLFSCSLPG--KTKL-KLLWHI-------------------------- ------LGKSQPHQ-P-PC-LGLLHCLYEN-QDMKLLTHVMHDLQGTIVPDTDDITHTVL QTNVKHL-VVR-TDMELMVVT-----FC-IQFCSHMRSLQLNME-G--QQGYALTAPR-- -----------MVL-YRWTPIT-NASWKILFYNLK-FNSN--LEGLDLSGNPLSYSAVQY L------CDAMIYP------GCQLKTL--------------------------------- ------------------------------------------------------------ --------W--------------------------------------------------- ------------------------------------------------------------ -----------LVECGLTPTY----CSLLASVLSACSS-LREL----------------- --------------------------------------------DLQLNDLCDDGVRMLC EGLRNRACNLRIL----------------------------------------------- ---------RLDLYSLSAQVITELRTLEENN-LKLHISSIWMPQMMVPTENMDEEDILTS ---FKQQRQQSGA----------------------------------------------- -------NPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLPMAGSYHCPSTRLHFVVT RAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTAVYLPHFVSLKDTKASTF DFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIPAARHFIPITSITLIYYR VNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDNLFIGSRYIVSGSEN--L EITPKELELCYRSSKEFQLFSEIYVGNMGSEIKLQIKNKKHMKLIWEALLKPG--DLRPA LPRIAQALK---------------DAPSLLHFMDQHREQL--VARVTSVDPL-LDKLHGL VLNEESYEAVRAENTNQDKMRKLFN----L-SRSWSRACKDLFYQALKETHPHLVMDL-- LEKSGGVSLGS------------------------------------------- >M_musculus_ENSMUSP00000063752 ------------------------------------------------------------ ------------------------M----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------YMKQKKENLYS--TQPSKGENLSQNFTNLLLSQKL---CPQGSKTFARKS WHQCVPEERGHMIEIQDLFGQNLNKQEKAQL--VVIVGAAGIGKSTLAR-QVRNAWKEGQ LYRDHFQHVFFFSCTELSK-SKQLS--LAEFIAQG--QEVPTAPIRQILSH-PEELLFIL DGIDEPAWV------LK--DQDP----ELCLHWSQMQPVHTLLGSLLGKSILPGASFLLT ARTTALKKFISNFKQPWQVEVLGFTMLERKNYFYKYFEKEI---------EAIAAFRLIK SNSVLLTLCEVPWVCCLVCNCLK-----KQMDQG-RVISL--TSQTTTALCLKYLSLTI- ----------------PGKHRRTQLRALCSLAAEGIW-KRRTLFSESDLCKQGLEEDA-I ATF--LKIGVLKKQA---SSLSYSFAHL-CLQEFFAAMSYILEDSEGRH----------- --------------------------GDMKIN--RTVRILVKRYGRQ-NLFEAPTVRFLF GLLSKEGFKEMQKVFSCKLSG--KSKL--MIRHI-------------------------- ------LQKLQPHQ-P-SC-LGLLHCLYEK-QEMELLTLMMHDLRGTIMHGLINIAHTVL QRNLKNL-VIQ-TDMDLMVVT-----FF-IRLCSHVRSLQLNRK-G--QQGYKLMAPG-- -----------MVL-YRWTPIT-DSSWKIFFFNLK-FTTN--LEELDLSGNPLSYSAACS L------CKALRHP------GCQLKTL--------------------------------- ------------------------------------------------------------ --------W--------------------------------------------------- ------------------------------------------------------------ -----------LVECGLTSTY----CSLLASVLSACSS-LTEL----------------- --------------------------------------------NLRLNYLGNRGVKLLC EGLRNPACNLSTL----------------------------------------------- ---------WLDVASLREEVITELRTLEAKN-LKLLISRACKSHVIVPTKNMDKEEVGDS LDLLKQQRQQSG------------------------------------------------ ------DKHMEPLGTDYDFWGSTGPVATEVVDRERNLYRVQLPMAGSYHSPSTGLHFVVT RAVTIEIEFCAWSQYLDKTPLKHSHMVAGPLFDIKAEQGTVSAVYLSRFVSLQEGIVDSS LFHVAHFQEHGIIPRNTSKGGTALCSTGKPKLLPNG---------------NSTE----- --------------NDSGCR---------------------------------------- -------------------------------------------------------TLHPH ------------------------------HF--HHTDLLSPLSRGCHLSPL-LG----- ---------------------------------------------------PQ------- ------------------------------------------------------ >M_domestica_ENSMODP00000014409 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RDLNKEFVPLMLLHK-----YKELKNICRKN TPVSVMTKQAHIIDMSELFGSD-ERKYVPQT--VVLCGGAGIGKTILTR-KIMLDWAEGD LFQDRFKNVIYVNCKTINL-TLEMT--LVDLISKD--WPDLQASIEAIMSN-PKQLLFII DGFDEVKWP------FV--EPEP----ELCHHWKEKCPVPVLLRSLLWKTIFPRSSLLIA TRSSALMRFRCLIDDPNCVEVLGFTEANIEMYISKFFKSEA---------KVLKVLDLLK VSDTLSEKCSVPLECWIICTCLK-----QQMERG-EVPVL--LPQTTTDLYVSYLSFGLS HDGSS-----------SSQHHDLQLRRLCSLAAEEVW-AGKFTFNEDDLKRHGLD-VS-D DSF--LNMYILEKKD---KENCYSFIHG-RFLEFFAAMFYVLEEKREER----------- --------------------------DYPAVAVKDVIELLVQ--TRE-SDSEVSIMNFLF GLLNEETMRQLDRNFVYPTIQ--RGKA-ELLQWMILESN--------------------- -----IQRMINPLL-H-PDPLELFQCLYEI-RQEELVRKTMKYFQSM------------- -----RL-NLH-TSKDILVSI-----FC-IKLCYNLVNIHLHIS-RTLTNANHFFVSS-- -----------LRM-YN-SPHI-LIQWKELISVLL-FKKS--LIELELSGSFPDDRLMKI V------YKEIMHP------NCKLHTL--------------------------------- ------------------------------------------------------------ ---SI-I------DFF--KLLPPALQ-------SILSVG-SKAEEPKGKIKTIKKVPPIQ -SQARTSIIL-------------------------------------------------- -----------KLPCTLKCDCHLSICSILGSILDIRFE-PGNE----------------- --------------------------------------------SLSL-DLHRFIVSYCN NLLFSFSFNNIIP----------------------------------------------- ---------ILTDSSNSDIVTLLLLSLMNKT-QKLFNKLTYRRQLVTPTYMNKDGR---- ---LEKQKSYQNWDLIVWLEDSVSSFPEL-----------FPEEVTPQTEAEVTSLLASF DPLKEEQLDLEKC----LFLGPNGPVEPEWIDKKRNIYKVRLSMAGFYHCPYTGLGFDVR SEVTVDIEFGTWNQHLDWIQ-QQSWMIAGPLFHITVDPGVVTSVHLPHFVHLQGGKVDIS LFKIAHFKEEGMVLENPTRMESSHAILENPSFSPMGVLLRIVHSTFRFIPIYSTTLIYFR LRAEDITLHLYLIPSDCTIRKAIDEEEAKFHFLRLHKPSPVTPLYIGSRFLVSGSKH--L EIMPTELELCYQSAGECQFFSEIYTSNVKEIISLDLRDPK-GTVVWGTLVRSGRIKLVIS LISMQHGTF-----LSRPHQSLPYSLLPELHFVDQHRNQI--ISRVTSVDII-LDRLHSQ FLSNEDYEHIRAEKTNPEKMRRLFS----F-SPSWSKDYKDHLYRVLREIHPHLMNELEH MEKILVRK---------------------------------------------- >M_domestica_ENSMODP00000011060 ------------------------------------------------------------ --------------------------------LVRYLEELTFEELKKFKLFLEDSPPK-- ----E-KFL-RIPRSQMKKADNTDM-AELMVHHYGE-GEAWDVALMIW-----EKMGLRE LWEQAKREAPQ--------------------------MGKYGETFAYKDERLGHRENKS- ------------------------------------------------------------ ----QRILSC-------------------------------------------------- ----QTTYRNRIMEKFRVMRDRNSCPGEYENLHHRFTRLLLLQEY--------------- -------------QVASLFDPDKKREAHPQV--VVLQGAAGIGKTTLAR-KVILDWAEGN LYQDKFDYVFYLHCREMNH-LREKKIRFADLIAND--WPFLEASMKRILSH-PEKLLFVI DGLDELKFS------CD--EHSY----DLCKDWNLQQPVPILLSSLLRKTMLLESSLLIT TRLTALEKCDFLFENPRHVEILGFSEEDRWKYFCKFFGDED---------QAQQAFSLIV NNETLFTMCFVPLMCWIICTCMK-----QQMRRK-KDLKQ--ASKTTTTLYMCYLSSLAT PGARS--------------CSVQHHRSLCRMAAEGIW-EGKILFDGDDLRRHGLEASD-V SAF--LDMHIFQKDSD--SENCYSFIHL-SFQEFFAAMFYALGEEKETG----------- ---------GR-------------AVPPIPGV--KDL--LAKCRDSA-TSFVALTVHFLF GFLNADNRKRLEEIYDCKISQ--EIKL-ELLQWIQAVTE--------------------- -----QQH---KDPSLRNDLLEMFSHLYET-QDEEFVTTAMAHFQEI------------- -----SL-NIY-SKLHFLISV-----FC-IKFCHNLGKIRLNIA-WMYRSKIQSAGITQ- -----------TWQ-LPFFQLA-VVDWQHLFSVLS-KNQN--LRTLDLSGTELANSAVNA L------CSELSQS------SCKLQKLSLSKC-------------Q------LTASCCQH LSSLLK------------------NNKNLTYLDLSMN-FLGD-EGIKALCEVLRNQNCNI QELNL-SRCRFSDACC--KNLSSALMAH-GNI-NILDLS-ENTLADVGMNLLCEALG--S -SDCNLQELK-------------------------------------------------- -----------LSQCHFTDAC----CQDLSTCI-KNQS-LIHL----------------- --------------------------------------------DVSGNFLQDSGIRLLC EALRHPTCNLQKL----------------------------------------------- ---------LLSLCHITDSSCQDVSFALKNN-RSL------------------------- ------------------------------------------------------------ ---------------------------------------IHLDLGCNN-LYNHGVKLLCE A----------------------------------------------------------- --------------------------LENQNCN--------------------------- -----------------------------------------------------------L QTL--ELWNCQLSAACCH-------------------------------------EFSSV LKK---NQS---------------------------------LTHLNLGANP-LRNNGVK VLCEALG-----NQNCK---LQKLK----L-CKCLLSAVGCRYLSTALKSNQNLTHLKLT GNGLGDDGVKLLFEALKNSDCKLQKL---------------------------- >H_sapiens_ENSP00000375653 ------------------------------------------------------------ --------------------MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATEL-- ------GEG-KIPWGSMEKAGPLEM-AQLLITHFGP-EEAWRLALSTF-----ERINRKD LWERGQREDL-------------VRDTPPG----------GPSSLGN---QSTCLLEVSL V----------------------------------------------------------- ----TPRKDP-------------------------------------------------- ----QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGR GHARTVGHQASPIKIETLFEPDEERPEPPRT--VVMQGAAGIGKSMLAH-KVMLDWADGK LFQGRFDYLFYINCREMNQSATECS--MQDLIFSC--WPEPSAPLQELIRV-PERLLFII DGFDELKPS------FH--DPQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLIT TRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QAGQVFNYVR DNEPLFTMCFVPLVCWVVCTCLQ-----QQLEGG-GLLRQ--TSRTTTAVYMLYLLSLMQ PKPGA-----------PRLQPPPNQRGLCSLAADGLW-NQKILFEEQDLRKHGLDGED-V SAF--LNMNIFQKDIN--CERYYSFIHL-SFQEFFAAMYYILDEGEGGA----------- --------------------------GPDQDV--TRL--LTEYAFSE-RSFLALTSRFLF GLLNEETRSHLEKSLCWKVSP--HIKM-DLLQWIQSKAQ--------------------- -----SDG---STL-Q-QGSLEFFSCLYEI-QEEEFIQQALSHFQVI------------- -----VVSNIA-SKMEHMVSS-----FC-LKRCRSAQVLHLYGA-TYSADGEDRARCSAG AHTLL------VQLRPERTVLL-DAYSEHLAAALC-TNPN--LIELSLYRNALGSRGVKL L------CQGLRHP------NCKLQNLRLKRC-------------------RISSSACED LSAALI------------------ANKNLTRMDLSGN-GVGF-PGMMLLCEGLRHPQCRL QMIQL-RKCQLESGAC--QEMASVLGTN-PHL-VELDLT-GNALEDLGLRLLCQGLR--H -PVCRLRTLW-------------------------------------------------- -----------LKICRLTAAA----CDELASTLSVNQS-LREL----------------- --------------------------------------------DLSLNELGDLGVLLLC EGLRHPTCKLQTL----------------------------------------------- ---------RLGICRLGSAACEGLSVVLQAN-HNL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSFND-LGDWGLWLLAE G----------------------------------------------------------- --------------------------LQHPACR--------------------------- -----------------------------------------------------------L QKL--WLDSCGLTAKACE-------------------------------------NLYFT LGI---NQT---------------------------------LTDLYLTNNA-LGDTGVR LLCKRLS-----HPGCK---LRVLW----L-FGMDLNKMTHSRLAALRVTKPYLDIGC-- ------------------------------------------------------ >P_troglodytes_ENSPTRP00000019647 ------------------------------------------------------------ --------------------MLRTAGRDGLCRLSTNLEELEAVELKKFKLYLGTATEL-- ------GEG-KIPWGRMKKAGPLEM-AQLLITHFGP-EEAWRLALSTF-----ERINRKD LWERGQREDL-------------VRDTPPG----------GPSSLGN---QSTCLLEVSL V----------------------------------------------------------- ----TPRKDP-------------------------------------------------- ----QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGR GHARTVGHQASPIKIETLFEPDEERPEPPRT--VVMQGAAGIGKSMLAH-KVMLDWADGK LFQGRFDYLFYINCREMNQSATECS--MQDLISGC--WPEPSAPLQELIRV-PERLLFII DGFDELKPS------FH--DAQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLIT TRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QAGQVFNYVR DNEPLFTMCFVPLVCWVVCTCLQ-----QQLEGG-GLLRQ--TSRTTTAVYMLYLLSLMQ PKPGA-----------PRLQPPPNQRGLCSLAADGIW-NQKILFEEQDLRKHGLDGED-V SAF--LNMNIFQKDMN--CERYYSFIHL-SFQEFFAAMYYILDEGERGA----------- --------------------------GPDQDV--TRL--LTEYAFSE-RSFLALTSRFLF GLLNEETRSHLEKSLCWKVSP--HIKM-DLLQWIQSKAQ--------------------- -----SDG---STL-Q-QGSLEFFSCLYEI-Q-KEFTQQALSHFQVI------------- -----VVSNIA-SKMEHMVSS-----FC-LKHCRSAQVLHLYGA-TYSADGEDRARCSAG THTLL------VQLRPERTVLL-DAYSEHLAAALC-TNPN--LIELSLYRNALGSRGVKL L------CQGLRHP------NCKLQNLRLKRC-------------------RISSSACED LSAALI------------------ANKNLTRMDLSGN-GVGF-PGMMLLCEGLRHPQCRL QMIQL-RKCQLESGAC--QEMASVLGTN-PHL-VELDLT-GNALEDLGLRLLCQGLR--H -PVCRLRTLW-------------------------------------------------- -----------LKICRLTAAA----CDELASTLSVNQS-LREL----------------- --------------------------------------------DLSLNELGDLGVLLLC EGLRHPTCKLQTL----------------------------------------------- ---------RLGICRLGSAACEGLSVVLQAN-HNL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSFND-LGDWGLWLLAE G----------------------------------------------------------- --------------------------LQHPACR--------------------------- -----------------------------------------------------------L QKL--WLDSCGLTAKACK-------------------------------------NLYFT LGI---NQT---------------------------------LTDLYLTNNA-LGDTGVR LLCKRLS-----HPGCK---LRVLW----L-FGMDLNKMTHSRLAALRVTKPYLDIGC-- ------------------------------------------------------ >B_taurus_ENSBTAP00000001675 ------------------------------------------------------------ -----------------------MRMVSVRCKLARYLEDLEDIDFKKFKMHLEDYPSQ-- ----K-GCT-SIPRGQTEKADHVDL-ATLMIDFNGE-EKAWAMAKWIF-----AAINRRD LYEKAKREEP-------------EWEN-----ANISVLSQEESLEEEWMGLLGYLSRISI C----------------------------------------------------------- ----RKKKDY-------------------------------------------------- ----CKKYRKYVRSKFQCIKDRNARLGESVNLNKRFTRLRLIKEHRSQQEREHELLAIGR TWAKIQDSPVSSVNLELLFDPEDQHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWASEK LYQDRFDYLFYIHCREVSL-GTQRS--LGDLIASC--CPGPNPPIGKIVSK-PSRILFLM DGFDELQGA------FD--EHTE----ALCTNWRKVERGDILLSSLIRKRLLPEASLLIT TRPVALEKLQHLLGQARHVEILGFSEARRKEYFLKYFSDEQ---------QAREAFRLIQ ENEILFTMCFIPLVCWIVCTGLK-----QQMDSG-KSLAR--TSKTTTAVYIFFLSSLLQ SQGGS-----------QENHNSATLWGLCSLAADGIW-NQKILFQECDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEDNHGEM-R-------- -----NTPQAC-------------SKLPNRDV--KVL--LENYGKFE-KGYLIFVVRFLF GLINQERTSYLEKKLSCKISQ--KIRL-ELLKWIEAKAN--------------------- -----AKT---LQI-E-PSQLELFYCLYEM-QEEDFVQRAMSHFPKI------------- -----EI-KLS-TRMDHVVSS-----FC-IENCRHVESLSLRLL-HNSPKEEEEEEE--- ------------------------------------------VRHSHMDRSVLSD-FEVA Y------SQGLV--------N-YLTS-----------------------------SICRG IFSVLS------------------NNWNLTELNLSGN-TLGD-PGMNVLCETLQQPGCNI RRLWL-GQCCLSHQCC--FNISSVLSNN-QKL-VELDLS-HNALGDFGIRLLCVGLR--H -LFCNLKKLW-------------------------------------------------- -----------LVSCCLTSAS----CEDLASVLSTNHS-LTRL----------------- --------------------------------------------YLGENALGDSGVGILC EKVKNPHCNLQKL----------------------------------------------- ---------GLVNSGLTSGCCPALSSVLSTN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLQGNA-LGDMGVKLLCE G----------------------------------------------------------- --------------------------LLHRNCK--------------------------- -----------------------------------------------------------L QVL--ELDNCSLTSHCCW-------------------------------------DLSTL LTS---NQS---------------------------------LRKLCLGNND-LGDLGVM LLCEVLK-----QQGCL---LKSLR----L-CEMYFNYDTKRALETLQEEKPELTIVFEP SR---------------------------------------------------- >P_troglodytes_ENSPTRP00000003728 ------------------------------------------------------------ -----------------------MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQ-- ----K-GCI-PLPRGQTEKADHVDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LYEKAKRDEP-------------KWGSDNACVSNPTVICQEDSIEEEWMGLLEYLSRISI C----------------------------------------------------------- ----KMKKDY-------------------------------------------------- ----RKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK T--KACESPVSPIKMEMLFDPDDEHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWALGT LYQDRFDYLFYIHCREVSL-VTQRS--LGDLIMSC--CPDPNPPIHKIVRK-PSRILFLM DGFDELQGA------FD--EHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEA---------QARAAFSLIQ QNEVLFTMCFIPLVCWIVCTGLK-----QQMESG-KSLAQ--TSKTTTAVYVFFLSSLLQ PRGGS-----------QEHRLCAHLWGLCSLAADGIW-NQKILFEESDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEEKEGRT---------- -----NVPGSR-------------LKLPSRDV--TVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QIRL-ELLKWIEVKAK--------------------- -----AKK---LQI-Q-PSQLELFYCLYEM-QEEDFVQRAMDYFPKI------------- -----EI-NLS-TRMDHVVSS-----FC-IENCHRVESLSLGFL-HNMPKEEEEEEKE-- ------------------------------------------GRHPDMVQCVLPGSSHAA C------SHGLV--------NSHLTS-----------------------------SFCRG LFSVLS------------------TSQSLTELDLSDN-SLGD-PGMRVLCETLQHPGCNI RRLWL-GRCGLSHECC--FDISLVLSSN-QKL-VELDLS-DNALSDFGIRLLCVGLK--H -LLCNLKKLW-------------------------------------------------- -----------LVSCCLTSAC----CQDLASVLSTSHS-LTRL----------------- --------------------------------------------YVGENTLGDSGVAILC EKAKNPQCNLQKL----------------------------------------------- ---------GLVNSGLTSVCCSALSSVLSTN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRGNT-LGDKGIKLLCE G----------------------------------------------------------- --------------------------LLHPDCK--------------------------- -----------------------------------------------------------L QVL--ELDNCNLTSHCCG-------------------------------------DLSTL LTS---SQS---------------------------------LRKLSLGNND-LGDLGVM MFCEVLK-----QQSCL---LQNLG----L-SEMYFNYETKSALETLQEEKPELTVVFEP SW---------------------------------------------------- >H_sapiens_ENSP00000375704 ------------------------------------------------------------ -----------------------MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQ-- ----K-GCI-PLPRGQTEKADHVDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LYEKAKRDEP-------------KWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI C----------------------------------------------------------- ----KMKKDY-------------------------------------------------- ----RKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK T--KTCESPVSPIKMELLFDPDDEHSEPVHT--VVFQGAAGIGKTILAR-KMMLDWASGT LYQDRFDYLFYIHCREVSL-VTQRS--LGDLIMSC--CPDPNPPIHKIVRK-PSRILFLM DGFDELQGA------FD--EHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEA---------QARAAFSLIQ ENEVLFTMCFIPLVCWIVCTGLK-----QQMESG-KSLAQ--TSKTTTAVYVFFLSSLLQ PRGGS-----------QEHGLCAHLWGLCSLAADGIW-NQKILFEESDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEEKEGRT---------- -----NVPGSR-------------LKLPSRDV--TVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QIRL-ELLKWIEVKAK--------------------- -----AKK---LQI-Q-PSQLELFYCLYEM-QEEDFVQRAMDYFPKI------------- -----EI-NLS-TRMDHMVSS-----FC-IENCHRVESLSLGFL-HNMPKEEEEEEKE-- ------------------------------------------GRHLDMVQCVLPSSSHAA C------SHGLV--------NSHLTS-----------------------------SFCRG LFSVLS------------------TSQSLTELDLSDN-SLGD-PGMRVLCETLQHPGCNI RRLWL-GRCGLSHECC--FDISLVLSSN-QKL-VELDLS-DNALGDFGIRLLCVGLK--H -LLCNLKKLW-------------------------------------------------- -----------LVSCCLTSAC----CQDLASVLSTSHS-LTRL----------------- --------------------------------------------YVGENALGDSGVAILC EKAKNPQCNLQKL----------------------------------------------- ---------GLVNSGLTSVCCSALSSVLSTN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRGNT-LGDKGIKLLCE G----------------------------------------------------------- --------------------------LLHPDCK--------------------------- -----------------------------------------------------------L QVL--ELDNCNLTSHCCW-------------------------------------DLSTL LTS---SQS---------------------------------LRKLSLGNND-LGDLGVM MFCEVLK-----QQSCL---LQNLG----L-SEMYFNYETKSALETLQEEKPELTVVFEP SW---------------------------------------------------- >C_familiaris_ENSCAFP00000015730 ------------------------------------------------------------ -------------------------MASVRCKLARYLEDLEDADFKKFKMHLQDYPSQ-- ----K-GFS-PLPRSQTEKADHMDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LYEKAKRDEL-------------EWVLKTQNVDNSHLECREESLEEEWMGLLGYLSRISI C----------------------------------------------------------- ----KKKKDY-------------------------------------------------- ----CKKYKKHVRSRFQCIKDRNARLGETVNLNKRYTRLRLVKEHQSQQEREHELLAIGR TSAKTLDSPMSSVNVELLFEPDDQHLEPVHT--VVFQGSAGIGKTILAR-KIMLDWASDK IYQDRFDYLFYIHCREVSL-GTRRS--LGDLIVSC--CPDPNPPICKIVSK-PSRILFLM DGFDELQGA------FD--EHTE----ALCTNWQKVERGDILLSSLIRKRLLPEASLLIT TRPVALEKLQHLLDRPRHVEILGFSEAKRKEYFFKYFSDEQ---------QATEAFRLIQ ENEILFTMCFIPLVCWIVCTGLK-----QQMDSG-KNLAQ--TSKTTTSVYIFFLSSLLQ SHRET-----------QKHQVSASLRGLCSLAADGIW-NQKILFDECDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEEEQGRM-R-------- -----NLPWSS-------------SKLPNRDV--KVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QIRL-ELLKWIEEKAK--------------------- -----GKN---LQI-Q-PSQLELFYCLYEM-QEEDFVRKAMGHFPKI------------- -----EI-SLS-TRMDHVVSS-----FC-IENCCRVESLSLRLL-HNSPWGLVSEEQI-- -------------------------------------MQDTMGRDMVSLEVIMRARACFV C------SRTLV--------NCQVTV-----------------------------SLWQG LFSVLS-----------------RNSLSLTELNLSDN-ALGD-QGVNVLCEMLQHPGCNI RKLWL-GQCCLSYRCC--FNISSVLSNN-QKL-EELDLS-HNALGDFGIRLLCVGLK--H -LFCNLNKLW-------------------------------------------------- -----------LVSCCLTPAC----CEDLASVLSTNQS-LTRL----------------- --------------------------------------------YLGENSLEDAGVGVLC EKAKHPQCKLQRL----------------------------------------------- ---------GLVNSGLTPGCCPALASMLSTN-QKL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRGNA-LGDTGVKLLCE G----------------------------------------------------------- --------------------------LLHPNCK--------------------------- -----------------------------------------------------------L QIL--ELDGCSLTSHCCW-------------------------------------DLSTL LTS---SKS---------------------------------LRELSLGSND-LGDLGVM LLCEVLK-----QQGCI---LQSLK----L-CEMYFNYDTKCALETLQEEKPELTIVFEP FG---------------------------------------------------- >M_musculus_ENSMUSP00000078440 ------------------------------------------------------------ -------------------------MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPE-- ----K-GCI-PVPRGQMEKADHLDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LWEKAKKDQP-------------EWND--TCTSHSSMVCQEDSLEEEWMGLLGYLSRISI C----------------------------------------------------------- ----KKKKDY-------------------------------------------------- ----CKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQEREHELLTIGR T--KMRDSPMSSLKLELLFEPEDGHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWALGK LFKDKFDYLFFIHCREVSL-RTPRS--LADLIVSC--WPDPNPPVCKILRK-PSRILFLM DGFDELQGA------FD--EHIG----EVCTDWQKAVRGDILLSSLIRKKLLPKASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNEL---------QAREAFRLIQ ENEVLFTMCFIPLVCWIVCTGLK-----QQMETG-KSLAQ--TSKTTTAVYVFFLSSLLQ SRGGI-----------EEHLFSDYLQGLCSLAADGIW-NQKILFEECDLRKHGLQKTD-V SAF--LRMNVFQKEVD--CERFYSFSHM-TFQEFFAAMYYLLEEEAEGETVR-------- -----KGPGGC-------------SDLLNRDV--KVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QVRL-ELLKWIEVKAK--------------------- -----AKK---LQW-Q-PSQLELFYCLYEM-QEEDFVQSAMDHFPKI------------- -----EI-NLS-TRMDHVVSS-----FC-IKNCHRVKTLSLGFF-HNSPKEEEEERRG-- ------------------------------------------GRPLDQVQCVFPD-THVA C------SSRLV--------NCCLTS-----------------------------SFCRG LFSSLS------------------TNRSLTELDLSDN-TLGD-PGMRVLCEALQHPGCNI QRLWL-GRCGLSHQCC--FDISSVLSSS-QKL-VELDLS-DNALGDFGIRLLCVGLK--H -LLCNLQKLW-------------------------------------------------- -----------LVSCCLTSAC----CQDLALVLSSNHS-LTRL----------------- --------------------------------------------YIGENALGDSGVQVLC EKMKDPQCNLQKL----------------------------------------------- ---------GLVNSGLTSICCSALTSVLKTN-QNF------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRSNA-LGDTGLRLLCE G----------------------------------------------------------- --------------------------LLHPDCK--------------------------- -----------------------------------------------------------L QML--ELDNCSLTSHSCW-------------------------------------NLSTI LTH---NHS---------------------------------LRKLNLGNND-LGDLCVV TLCEVLK-----QQGCL---LQSLQ----L-GEMYLNRETKRALEALQEEKPELTIVFEI SW---------------------------------------------------- >E_caballus_ENSECAP00000015250 ------------------------------------------------------------ --------------------MPQIPVRDGLCRLSAYLEELEAVELKKFKLYLGTATEP-- ------GEA-KIPRGRMEQAGPLEM-AQLLVAHCGM-QEAWLLALSIF-----ERINRKD LWERGRREDL-------------VRDTPPG----------GLSSLGS---QSACSLEVFP G----------------------------------------------------------- ----TPRKDP-------------------------------------------------- ----RESYRNHVRRKFRLMEDRNARLGECVNLSQRYTRLLLVKEHSNPTWAQQKLLDTGR GHTRTVGQQASLIQMETLFEPDEERPEPPRT--VVLQGAAGMGKSMLAH-KVMLDWADGK LFQDRFDYVFYIHCREMNQNASERS--AQDLISSC--WPEPGAPLQELLRA-PERLLFIL DGFDELKPS------FH--DPQG----PWCLCWEEKRPTELLLSSLIRKKLLPELSLLIT TRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QAGQVFHFVR DNEPLFTLCFVPMVCWVICTCLK-----QQLEGG-RLLRQ--TSRTTTAVYTLYLLSLMQ PKPGT-----------PTLQIPPNQRGLCSLAADGLW-NQKILFEEQDLRKHGLDGVD-V SSF--LNMNIFQKDIN--CERFYSFIHL-SFQEFFAAMHYILEDGESGS----------- --------------------------GPDQNV--ARL--LAECGFSE-RSFLALTVRFLF GLLNEQTRSYLEKSLCWKVSP--RVKA-ELLEWIESKAQ--------------------- -----SEG---SML-Q-QGCLELFSCLYEI-QEEEFIQQALSHFQVV------------- -----VVSNIA-TRMEHMVSC-----FC-VKNCRNVVVLHLCGA-AYSADEEDGLRGAEG PQAPL------AQP-PERNILP-DAYSEQLASALS-TNPN--LIELVLYRNALGSRGVKL L------CQGLRHP------NCKLQNLRLKRC-------------------QLSGPACWD LAAALI------------------ANKNLIRMDLSGN-GLGL-PGIRLLCEGLRHPRCRL QMIQL-RKCQLEAGAC--REIASVLSTN-RHL-VELDLT-GNALEDLGGRLLCEGLS--N -PVCRLQILW-------------------------------------------------- -----------LKICRLTAAA----CEDLASTLSVNQS-LVEL----------------- --------------------------------------------DLSLNDLGDAGVLLLC EGLRHPQCKLQTL----------------------------------------------- ---------RLGICQLSSAACEGLSAVLQVN-PHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSFND-LGDRGVWLLCE G----------------------------------------------------------- --------------------------LRHPTCR--------------------------- -----------------------------------------------------------L QKL--WLDSCGLTAKACE-------------------------------------ALSCS LGV---NRT---------------------------------LRELYLTHNA-LGDTGVR LLCKRLS-----HAGCP---LRVLW----L-FGMALNPMTHRRLAALRVAKPSLDLGC-- ------------------------------------------------------ >B_taurus_ENSBTAP00000051805 ------------------------------------------------------------ -------------------------LRSDLGRLCTYLEELEAVELKKFKLYLGTATEM-- ------GEG-KIPWGRMEQAGPLEM-AQLLAAHFGP-QEAWLLALSVF-----HQINRKD LWERGHREDQ-------------DPWATLHLVAHPHWAASQHVLWTSWLPLREKVSHEVL H----------------------------------------------------------- ----SSPLDP-------------------------------------------------- ----QETYRDYVRRKFRLMEDRNARLGEFVNLSHRYTRLLLAKEHSSPRWAQQKLLDTGR GHAGTAGHPASLIQIEALFEPDEERPEPPRT--VVLQGAAGMGKSMLAH-KVMLDWADGK LFQNRFDYVCYINCREMNRGTAELS--VRDLLASC--WPEPCAPLQELVRV-PERLLVIM DGFDELRPS------FH--EPQG----PWCLCWEKKAPAEVLLGSLIRKKLLPELSLLIT TRPTALAKLQRSLEHPRHVAILGFSEAERKEYFHRYFHDRE---------QASQVFSFVR DDEPLFTLCFVPMVCWVVCTCLK-----QQLEGG-GLLRR--RSRTTTAVYLLYLLSLMQ PKPGT-----------PTLPSPPNRRGLCALAAHGLW-EQKILFAERDLREHGLDAAD-V SSF--LNMNIFQKDII--CETLYSFIHL-SFQEFFAAMHYVLDDGASGS----------- --------------------------GPERNL--SRL--LTEYAFSD-RSFLALTVRFLF GLLNEETRSYLEKTLGWKVSP--GVKT-ELLEWIRRKAR--------------------- -----SEG---STL-K-QGALEVFGCLYEL-QEEEFIQQALSHFQVV------------- -----VVNNIT-TKMEHMVSS-----FC-VKSCRNAEVLQLFGA-AYQAHGEDREDRRDK ------------------------------------TTPN----------------EITW L------FSSLR--------------LRLKRC-------------------QVSSSVCQD LTTALI------------------ANKHLLRMDLSGN-ALGL-LGAQLLCQGLRHPKCRL QVVQL-RKCHLEAGAC--QELASVLSTS-RHL-LELDLT-GNALEDSGLRLLCQGLR--H -PVCRLRILW-------------------------------------------------- -----------LKICLLTGAA----CEDLASTLHMNQS-LVEL----------------- --------------------------------------------DLSLNDLGDPGVLLLC EGLRHPQCKLQTL----------------------------------------------- ---------RLCICRLSSVACEGLSAVLGVS-SHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSFND-LGDRGMSLLCE G----------------------------------------------------------- --------------------------LRHPTCR--------------------------- -----------------------------------------------------------L QKL--WLDSCSLTGKACE-------------------------------------DISSA LGI---NQT---------------------------------LTDLYLTNNA-LGNTGVR LLCERLS-----HPGCK---LRVLW----L-FGMDLNKMTHRSLEALRMTKPYLDVGCLE NW---------------------------------------------------- >E_caballus_ENSECAP00000013016 ------------------------------------------------------------ -------------------------MASVRCKLARYLEDLEDADLKKFKMHLEDYPPQ-- ----K-GCT-RPPRGQTEKADPVDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LHEKAKLEEP-------------EWAH--SCCYRSHLICQEESIEEEWIGLLEYLSRISI C----------------------------------------------------------- ----KKKKDY-------------------------------------------------- ----CKKYRKHVRSRFQCIKDRNARLGESVNLNKRYTRLCLLKEHRSQQEREQELLAIGR TSPKTQDCPMSSMNLELLFEPDDQHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWASEK LYKNRFDYLFYIHCREVSL-GTRRS--LGDLIVSC--CPDPKPPIGKILSK-PSRILFLM DGFDELQGA------FD--EHTE----ALCTDWQKVERGDILLSSLIRKRLLPEASLLIT TRPVALEKLQHLLDRPRHVEILGFSEAKRKEYFFKYFSDEQ---------QAHEAFRLIQ ENEILFTMCFIPLVCWIVCTGLK-----QQMDSG-KSLAQ--TSKTTTAVYVFFLSSLLQ SRGES-----------QKQHLSANVRGLCSLAADGIW-NQKILFEESDLRKHGLQRAD-A SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEDEEQGSV-R-------- -----NMPWGR-------------SNLPNRDV--SVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QIRL-ELLKWISAKAE--------------------- -----VKK---LQT-Q-PSQLELFYCLYEM-QEEDFVRRAMGYFPKI------------- -----EI-SLS-TRMDHVVSS-----FC-IENCRSVESLSLRLL-YNSPKEEEEEEEE-- --------------------------------------------EEDGIDFLFSP-SSFL P------ISRLV--------NCSLTS-----------------------------SFCQS LFSALS------------------TNWSLTELNLGDN-TLGD-SGMKVLCDMLQHPGCNI QRLCA-THWGLKQQK---FTFSHLITSL-KAL-SPNTVT-FSGCGETGTTLHC-GWK--- ---CKMVQLL-------------------------------------------------- -----------LVGCCLTSAC----CEDLASVLSTSHS-LIRL----------------- --------------------------------------------YLGENALGDSGVGILC EKAKHPRCNLQVL----------------------------------------------- ---------GLVNSGLTSGCCPALSSVLSAN-HNL------------------------- ------------------------------------------------------------ ---------------------------------------KQLYLRGNA-LGDTGVKLLCE G----------------------------------------------------------- --------------------------LSHPNCK--------------------------- -----------------------------------------------------------L QML--ELDSCSLTSHCCW-------------------------------------DLSTL LTS---NQS---------------------------------LRELSLGGND-LGDLGVM LLCEVLK-----QQGCL---LRSLG----L-CEMYFNYETKCALETLQEEKPELSVVFEP SW---------------------------------------------------- >C_familiaris_ENSCAFP00000003989 ------------------------------------------------------------ --------------------MPRAPPSSGLCRLSAYLEELEAVELKKFKLFLGTEAE--- -------AG-RIPWGRLEAAGPLDT-AQLLVAHCGP-HAAWPLALGLF-----QRINRRD LWEKGRREEP-------------VRDTPSG----------DPSSPGS---QSACSLEVFP G----------------------------------------------------------- ----ALRRDP-------------------------------------------------- ----RETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMWAQQKLLDTGW GQARTVGHQASFIQMETLFEPDEERPEPPRT--VVLQGAAGMGKSMLAH-KVMLDWADGR LFQDRFDYLFYINCRKMNQSTAEQS--AQDLISSC--WPEPSVPLQELVRV-PERLLFII DGFHELKPS------FH--DPQG----PWCLCWEEKRPTELLLSSLIRKKLLPELSVLIT IRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QAGQVFNFIR DNEPLFTLCFVPMVCWVVCTCLK-----QQLEDG-GLLRQ--TSRTTTAVYMLYLLSLMQ PKPGS-----------PILQSPPNQRGLCSLAADGLW-NQKILFEEQDLRKHGLDGAD-V SSF--LNMNIFQKDIN--CEKFYSFIHL-SFQEFFAAMYYILDPGESRS----------- --------------------------SPEHNV--TRL--LAEYEFSE-RSFLALTVRFLF GLLNEETRSYLEKSLCWKVSP--HVKV-ELLEWIQRKAQ--------------------- -----SEG---STL-Q-QGSLELFSCLYEI-QEEDFIQQALSPFQVV------------- -----VVNNIA-TKMEHMISS-----FC-VKNCRSALVLHLHGA-AYSPDEDDGGRWASG PQMLP------TQI-PEKNVLP-DAYSKQLAAALS-TNPN--LTELVLYRSALGSRGVRL L------CQGLRHP------SCKLQNLSLKRC-------------------CVASSACQD LAAALM------------------ANQNLRRMDLSSN-RLGL-PGLRALCKGLRHPRCKL QVIQL-RKCQLEAEAC--QEIASVLSTS-RHL-EELDLT-GNALEDLGLKLLCQGLR--H -PVCRLQILW-------------------------------------------------- -----------LKICHLTAAA----CEDLASTLGVNQS-LIEL----------------- --------------------------------------------DLSLNDLGDPGVLLLC EGLRHPQCRLQAL----------------------------------------------- ---------RLGICRLSSAACKGLCTVLQVN-PCL------------------------- ------------------------------------------------------------ ---------------------------------------RDLDLSFND-LGDAGVWPLCE G----------------------------------------------------------- --------------------------LRHPTCR--------------------------- -----------------------------------------------------------L QKL--WLDSCGLTAKACE-------------------------------------DLSSA LGV---SQT---------------------------------LRELYLTNNA-LGNAGVR LLCKGLS-----HPGCK---LQVLW----L-FGMELNKMTHRRLAALRVVKPQLDIGC-- ------------------------------------------------------ >R_norvegicus_ENSRNOP00000004280 ------------------------------------------------------------ -------------------------MMSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPE-- ----K-GCV-PIPRGQMEKADHLDL-ATLMIDFNGE-EKAWGMAVWIF-----AAINRRD LWEKAKKDQP-------------EWND--ACTSNLSMVCQEDSLEEEWIGLLGYLSRISI C----------------------------------------------------------- ----KKKKDY-------------------------------------------------- ----CKIYRRHVRSRFYSIKDRNARLGESVDLNRRYTQLQLVKEHPSKQEREHELLTIGR T--KMWDRPMSSLKLELLFEPEDEHLEPVHT--VVFQGAAGIGKTILAR-KIMLDWALGK LFKDKFDYLFFIHCREVSL-RAPKS--LADLIISC--WPDPNPPVCKILCK-PSRILFLM DGFDELQGA------FD--EHIE----EVCTDWQKAVRGDILLSSLIRKKLLPKASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNEL---------QAREAFRLIQ ENEILFTMCFIPLVCWIVCTGLK-----QQMETG-KSLAQ--TSKTTTAVYVFFLSSLLQ SRGGI-----------EEHLFSAYLPGLCSLAADGIW-NQKILFEECDLRKHGLQKTD-V SAF--LRMNVFQKEVD--CERFYSFSHM-TFQEFFAAMYYLLEEEEEGVTVR-------- -----KGPEGC-------------SDLLNRDV--KVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QVRL-ELLKWIEVKAK--------------------- -----AKK---LQR-Q-PSQLELFYCLYEM-QEEDFVQSAMGHFPKI------------- -----EI-NLS-TRMDHVVSS-----FC-IKNCHRVKTLSLGFL-HNSPKEEEEEKRG-- ------------------------------------------SQPLDQVQCVFPD-PHVA C------SSRLV--------NCCLTS-----------------------------SFCRG LFSSLS------------------TNQSLTELDLSDN-TLGD-PGMRVLCEALQHPGCNI QRLWL-GRCGLTHQCC--FNISSVLSSS-QKL-VELDLS-DNALGDFGVRLLCVGLK--H -LLCNLQKLW-------------------------------------------------- -----------LVSCCLTSAC----CQDLALVLSSNHS-LTRL----------------- --------------------------------------------YIGENALGDSGVQVLC EKMKDPQCNLQKL----------------------------------------------- ---------GLVNSGLTSLCCSALTSVLKTN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRSNA-LGDMGLKLLCE G----------------------------------------------------------- --------------------------LLHPDCK--------------------------- -----------------------------------------------------------L QML--ELDNCSLTSHSCW-------------------------------------DLSTI LTH---NQS---------------------------------LRKLNLSNND-LGDLCVV TLCEVLK-----QQGCL---LQSLQ----L-GEMYLNCETKRTLEALQEEKPELTVVFEI SW---------------------------------------------------- >G_gorilla_ENSGGOP00000008682 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TPPG----------GPSSLGNMPSQSTCLLEVSL V----------------------------------------------------------- ----TPRKDP-------------------------------------------------- ----QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTXLLLVKEHSNPMQAQQQLLDTGR GHARTVGHQASPIKIETLFEPEEERPEPPRT--VVMQGAAGXGKSMLAH-KVMLDWADGK LFQGRFDYLFYINCREMNQSATECS--MQDLISSC--WPEPSAPLQELIRV-PERLLFII DGFDELKPS------FH--DPQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLIT TRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QADQVFNYVR DNEPLFTMCFVPLVCWVVCTCLQ-----QQLEGG-GLLRQ--TSRTTTAVYMLYLLSLMQ PKPGA-----------PRLQPPPNQRGLCSLAADGLW-NQKILFEEQDLRKHGLDGED-V SAF--LNMNIFQKDIN--CERYYSFIHL-SFQEFFAAMYYILDEGERGA----------- --------------------------GPDQDV--TRL--LTEYAFSE-RSFLALTSRFLF GLLNEETRSHLEKSLCWKVSP--HIKM-DLLQWIQSKAQ--------------------- -----SDG---STL-Q-QGSLEFFSCLYEI-QEEEFIQQALSHFQVI------------- -----VVSNIA-SKMEHMVSS-----FC-LKHCRSAQVLHLYGA-TYSADGEDRARCSAG AHTLL------VQLRPERTVLL-DAYSEHLAAALC-TXPN--LIELSLYRNALGSRGVKL L------CQGLRHP------NCKLQNLRLKRC-------------------RISSSACED LSAALI------------------ANKNLTRMDLSGN-GVGF-PGMMLLCEGLRHPXCRL QMIXX-XXXXXXXXXX--XXXXXXXXXX-XXX-XXXXXX-XXXXXXXXXXXXXXXXX--X -XXXXXXXXX-------------------------------------------------- -----------XXXXCLTAAA----CDELASTLSVNQS-LREL----------------- --------------------------------------------DLSLNELGDLGVLLLC EGLRHPTCKLQTL----------------------------------------------- ---------RXXXXXXXXXXXXXXXXXXXXX-XXX------------------------- ------------------------------------------------------------ ---------------------------------------XXXXXXXXX-XXXXXXXXXXX X----------------------------------------------------------- --------------------------XXXXXXX--------------------------- -----------------------------------------------------------X XXX--XLDSCGLTAKACK-------------------------------------NLYFT LGI---NQT---------------------------------LTNLYLTNNA-LGDTGVR LLCKRLS-----HPGCK---LRVLW----L-FGMDLNRMTHSRLAVLRVTKPYLDIGC-- ------------------------------------------------------ >M_mulatta_ENSMMUP00000011259 ------------------------------------------------------------ ------------------MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLK-ETME-- ----P-EHG-LIPWNEVKKARRDDL-ANLMKKYYPG-EKAWSVTLKIF-----GKMNLKD LCQRAKEE-----------------------------INWSAQSIGPDDAKVGVT--Q-- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GTEYRIRIKEKFCITWDKKSLAGKHEDFHHGIAE---KDRK--------------- -------------LLEHLFDVDVKTGEQPQT--VVLQGAAGVGKTTLVR-KAMLDWAEGN LYQQRFMYVFYLNGREINQ-LRERS--FAQLISKD--WPSTEGPIEEIISQ-PSSLLFII DSFDELNFA------FE--EPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT TRLTTSKRLKQLLKNHRYVELLGMSEGAREEYIYQFFEDKR---------WAMKAFSSLK SNEMLFSMCQVPLVCWATCTCLK-----QQMEKG-GDVTL--TCQTTTALFTSYISSLFT PVDGC----------SPRLPNQVQLRRLCHVAAKGIW-TMTYVFYRENLRRFGLTKSD-V SSF--LSNNIIQKDTE--YENCYVFTHL-HVQEFFAAMFYMLKGNWEAG--N-------- --------------------------PSCQPF--EDLKSLLQSTSYK-DPQLRQMKCFLF GLLNEDRVKQLERTFNCKMSL--KIKS-KLLQCMEVLGN--------------------- -----SDY---SPS-Q-LGFLELFHYLYET-QDKAFISQAMRYFSKV------------- -----AI-NIC-EKIHLLVSS-----FC-LKHCRCLRTIRLSVT-TVFEKKTLKTS---- -LPTN------TW---DGD-RI-THWWQDLCSVLH-TNEH--LRELDLCHSNLDKSAMNI L------HQELRHP------NCKLQKLLLKCI-------------TF-----P--DGCQD ISTSLI------------------HNQNLMHLDLKGS-DIGD-NGVKSLCEALKHPECKL QTLRL-ESCNLTVFCC--LSIFNVLIRS-QSL-IFLNLS-TNNLLDDGVQLLCEALR--H -PKCYLERLSLESCGL---TEAGCEDLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQ HAQC-TLQSLVSEQ-KYSTLF----SEYLSTSLLHNKS-LTHL----------------- --------------------------------------------DLGSNWLQDNGMKLLC DVFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTNACCLDLASVIVYN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGNNN-LQDDGVKILCD A----------------------------------------------------------- --------------------------LRYPNCN--------------------------- -----------------------------------------------------------I QRL--GLEYCGLTSLCCQ-------------------------------------DLSSA LIC---NQR---------------------------------LIKMNLTQNT-LGYEGIM KLYKVLK-----SPKCK---LQVLG----L-CKEAFDEEAQKLLEAVGVSNPHLI---IK PDCNYHNEENGSWWRCF------------------------------------- >E_caballus_ENSECAP00000009788 ------------------------------------------------------------ ------------------MTDSLSSSFFPDFGLLLYLEELNKEELNKFKLLLRNATME-- ----P-EHC-QIPWAEVKKAKREDL-ANLMNRYYPG-EQAWDVALKIF-----GKMNLKD LCERAKAE-----------------------------INWTTQSMGPEDARAGEA--QG- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GTEYRSRIKEKFCIMWDKECLLGEPKDFCHEIAQ---KGQE--------------- -------------LLEHLFDVDVKTGEQPQT--VVLQGAAGVGKTTLVR-KAMLDWAQGN LYQQRFAYVFYLNAREINQ-LRERS--FVQMISKD--WPSTEGPIERIMSQ-PSSLLFII DSFDELNFA------FE--EPEF----ALCEDWTQVHPVSFLMSSLLRKVMLPESSLLVT TRLTACKKLEPLLKSQRSVELLGMSEDAREEYIYQFFEDKK---------WALQVFGSLR NSEMLFSLCKVPLVCRVICTCLE-----QQMEKG---VTL--TCKTTTALFTCYISSLFT PADGS----------CPSLPNQTQLRSLCHLAAKGVW-TMTYVFYRENLRKHGLTKCD-V TIF--LDVNILQKDTE--YENCYVFTHL-HIQEFFAAMFYILKDSMETR--N-------- --------------------------LFFQSF--EDVKLLFESNSYK-DPHLMQMKCFLF GLLNEGLVKQLEDTFNCKMSL--GVKW-KILQWMEILGN--------------------- -----SDC---FPS-Q-LGFLELFHYLYET-QDEGFISQAMRYFRKV------------- -----VI-NIH-GKIHLLVSS-----FC-LKHCQSLQTIKLSVT-VESERKMLNSS---- -HSAE------TW---DFG-RI-THYWQDLCSVLH-TNEQ--LRELDLCHSNLDKLAMKT F------YQELRHP------NCKLQKLRLRFL-------------SF-----P--DGCQD ISRSLT------------------HNQNLMQLNLKGS-DIGD-NGVKSLCEALKRPECKL QNLTL-ESCDLTTVCC--LDISKALVRS-QSL-IFLNLS-TNNLLDDGVKLLCEALR--H -PKCYLERLSLESCGL---TVAGCEDLSSALISNKRLTHLCLADNNLGDGGVKLMSDALK HPQC-TLQSLVLRRCHFTALS----SEHLSSSLLHNKS-LTHL----------------- --------------------------------------------DLGSNQLQDDGVKLLC DVFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTSACCLDLSSAILNN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLYLGNND-LQDDGVKILFE A----------------------------------------------------------- --------------------------LRHPNCN--------------------------- -----------------------------------------------------------I QRL--RLEYCGLTSLCCQ-------------------------------------DLSST LSS---NQR---------------------------------LIKINLTQNT-LGCEGIM KLCEVLK-----SPECK---LQVLG----L-CKEALDEEAQKLLEAVGVSNPHLV---IK HDCNDHNEEDDSWWRCF------------------------------------- >H_sapiens_ENSP00000299481 ------------------------------------------------------------ ------------------MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLK-ETME-- ----P-EHG-LTPWNEVKKARREDL-ANLMKKYYPG-EKAWSVSLKIF-----GKMNLKD LCERAKEE-----------------------------INWSAQTIGPDDAKAGET--QE- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAE---KDRK--------------- -------------LLEHLFDVDVKTGAQPQI--VVLQGAAGVGKTTLVR-KAMLDWAEGS LYQQRFKYVFYLNGREINQ-LKERS--FAQLISKD--WPSTEGPIEEIMYQ-PSSLLFII DSFDELNFA------FE--EPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT TRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKR---------WAMKVFSSLK SNEMLFSMCQVPLVCWAACTCLK-----QQMEKG-GDVTL--TCQTTTALFTCYISSLFT PVDGG----------SPSLPNQAQLRRLCQVAAKGIW-TMTYVFYRENLRRLGLTQSD-V SSF--MDSNIIQKDAE--YENCYVFTHL-HVQEFFAAMFYMLKGSWEAG--N-------- --------------------------PSCQPF--EDLKSLLQSTSYK-DPHLTQMKCFLF GLLNEDRVKQLERTFNCKMSL--KIKS-KLLQCMEVLGN--------------------- -----SDY---SPS-Q-LGFLELFHCLYET-QDKAFISQAMRCFPKV------------- -----AI-NIC-EKIHLLVSS-----FC-LKHCRCLRTIRLSVT-VVFEKKILKTS---- -LPTN------TW---DGD-RI-THCWQDLCSVLH-TNEH--LRELDLYHSNLDKSAMNI L------HHELRHP------NCKLQKLLLKFI-------------TF-----P--DGCQD ISTSLI------------------HNKNLMHLDLKGS-DIGD-NGVKSLCEALKHPECKL QTLRL-ESCNLTVFCC--LNISNALIRS-QSL-IFLNLS-TNNLLDDGVQLLCEALR--H -PKCYLERLSLESCGL---TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQ HAQC-TLKSLVLRRCHFTSLS----SEYLSTSLLHNKS-LTHL----------------- --------------------------------------------DLGSNWLQDNGVKLLC DVFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTNACCLDLASVILNN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGNND-LQDDGVKILCD A----------------------------------------------------------- --------------------------LRYPNCN--------------------------- -----------------------------------------------------------I QRL--GLEYCGLTSLCCQ-------------------------------------DLSSA LIC---NKR---------------------------------LIKMNLTQNT-LGYEGIV KLYKVLK-----SPKCK---LQVLG----L-CKEAFDEEAQKLLEAVGVSNPHLI---IK PDCNYHNEEDVSWWWCF------------------------------------- >P_pygmaeus_ENSPPYP00000004039 ------------------------------------------------------------ ------------------MAD-SSSSFFPDFGLLLYLEELNKEELNTFKLFLK-ETME-- ----P-EHG-LTPWTEVKKARREDL-ANLMKKYYPG-EKAWSVSLKIF-----GKMNLKD LCERAKEE-----------------------------INWSAQNIGPDDAKAGET--Q-- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GTEYRIRIKEKFCITWDKKSLAGKPEDFHHGIAE---KDRK--------------- -------------LLEHLFDVDVKTGEQPQV--VVLQGAAGVGKTTLVR-KAMLDWAEGN LYQQRFKYVFYLNGREINQ-LKERS--FSQLISKD--WPSTEGPIEEIISQ-PSSLLFII DSFDELNFA------FE--EPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT TRLTTSKRLKQLLKNHCYVELLGMSEDARQEYIYQFFEDKR---------WAMKVFSSLK SNEMLFSMCQVPLVCWATCTCLK-----QQMEKG-GDVTL--ICQTTTALFTCYISSLFT PVDGR----------SPSLPNQAQLRRLCQVAAKGIW-TMTYVFYRENLRRLGLTKSD-V SSF--MDSNIIKKDAE--YENCYVFTHL-HVQEFFAAMFYMLKGNWEAW--N-------- --------------------------PSCQPF--EDLKSLLQSTSYK-DPQLTQMKCFLF GLLNEDRVKQLERTFNCKMSL--KIKS-KLLQCMEVLGN--------------------- -----SDY---SPS-Q-LGFLELFHYLYET-QDKAFISQAMRYFPKV------------- -----AV-NIC-EKIHLLVSS-----FC-LKHCRCLRTIRLSVT-GVFEKKILKTS---- -LPTN------TW---DGD-RI-THCWQDLCSVLH-TNEH--LRQLDLCHSNLDKSAMNI L------HHELRHP------NCKLQKLLLESC-------------NL-----T-VFCCLN ISNALI------------------RSQSLIFLNLSTN-NLLD-DGVQLLCEALRHPKCYL ERLSL-ESCNLTVFCC--LNISNALIRS-QSL-IFLNLS-TNNLLDDGVQLLCEALR--H -PKCYLERLSLESCGL---TEAGCEDLSLALISNKRLTHLCLADNVLGDGGIKLMSDALQ HAQC-TLKSLVLRRCHFTSLS----SEYLSTSLLHNKS-LTHL----------------- --------------------------------------------DLGSNWLQDNGVKLLC DVFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTNACCLDLASVILIN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGNND-LQDDGVKILCD A----------------------------------------------------------- --------------------------LRHPNCN--------------------------- -----------------------------------------------------------I QRL--ELEYCGLTSLCCQ-------------------------------------DLSSA LIC---NKR---------------------------------LIKMNLTQNT-LGYEGIV KLYKVLK-----SPKCK---LQVLG----L-CKEAFDEEAQKLLEAVGVSNPHLI---IK PDCNYHNEEDVSWWRCF------------------------------------- >P_troglodytes_ENSPTRP00000005793 ------------------------------------------------------------ ------------------MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLK-ETME-- ----P-EHG-LTPWTEVKKARREDL-ANLMKKYYPG-EKAWSVSLKIF-----GKMNLKD LCERAKEE-----------------------------INWSAQTIGPDDAKAGET--QE- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GTEYRIRIKEKFCITWDKKSLAGKPEDFHHGIAE---KDRK--------------- -------------LLEHLFDVDVKTGEQPQI--VVLQGAAGVGKTTLVR-KAVLDWAEGN LYQQRFKYVFYLNGREINK-LKERS--FAQLISKD--WPSTEGPIEEIISQ-PSSLLFII DSFDELNFA------FE--EPEF----ALCEDCTQEHPVSFLMSSLLRKVMLPEASLLVT TRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKR---------WAMKVFSSLK SNEMVFSMCQVPLVCWATCTCLK-----QQMEKG-GDVTL--TCQTTTALFTCYISSLFT PVDGG----------SPSLPNQAQLRRLCQVAAKGIW-TMTYVFYRENLRRLGLTKSD-V SSF--MDSNIIQKDAE--YENCYVFTHL-HVQEFFAAMFYMLKGSWEAG--N-------- --------------------------PSCQPF--EDLKSLLQSTSYK-DPHLTQMKCFLF GLLNEDRVKQLERTFNCKMSL--KIKS-KLLQCMEVLGK--------------------- -----SDY---SPS-Q-LGFLELFHCLYET-QDKAFISQAMRCFPKV------------- -----AI-NIC-EKIHLLVSS-----FC-LKHCRCLRTIRLSVT-VVFEKKILKTS---- -LPAN------TW---DGD-RI-THCWQDLCSVLH-TNEH--LRELDLCHSNLDKSAMNI L------HHELRHP------NCKLQKLLLKFI-------------TF-----P--DGCQD ISTSLI------------------HNKNLMHLDLKGS-DIGD-NGVKSLCEALKHPECKL QTLRL-ESCNLTVFCC--LNISNALIRS-QSL-IFLNLS-TNNLLDDGVQLLCEALR--H -PKCYLERLSLESCGL---TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQ HAQC-TLKSLVLRRCHFTSLS----SEYLSTSLLHNKS-LTHL----------------- --------------------------------------------DLGSNWLQDNGVKLLC DVFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTNACCLDLASVILNN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGNND-LQDDGVKILCD A----------------------------------------------------------- --------------------------LRYPNCN--------------------------- -----------------------------------------------------------I QRL--GLEYCGLTSLCCQ-------------------------------------DLSSA LIC---NKR---------------------------------LIKMNLTQNT-LGYEGIV KLYKVLK-----SPKCK---LQVLG----L-CKEAFDEEAQKLLEAVGVSNPHLI---IK PDCNYHNEEDVSWWRCF------------------------------------- >M_domestica_ENSMODP00000015678 ------------------------------------------------------------ ------------------------MADTILCCLVTYLEELECGELSKFKMYLGLEAER-- -----EGEE-RVPRGRMEKAGPLDL-AKILVAQWGP-AEAWELALRVF-----NRINRKD LWERGCQEPL-------------VRASGPT----------GPSGNGKRRKMMMME----- ------------------------------------------------------------ ----EPRKNP-------------------------------------------------- ----QETYREHVRRKYRFIEDRNARLGELVNLSQRYTRLLLVKEHATLIRAQRELLALGR QHALCLDQRASPIHIETLFEPDEERPEAPHS--VVLQGAAGIGKSILAQ-KVMLDWAEGH LYSDRFDYLFYVNCREMNQ-VRERS--LEDLISLC--WPERNVPISEIVRV-PERLLFII DGFDELQPF------FH--EPTD----CCCLRQGERRPVEALLSCLLTRKLLPERSVLIT TRPTTLETLRHLLEHPRHVEILGFSEAQRQEYFYKFFGNEE---------QARQGLAVVR DNEPLFTLCFVPMMCWIVCTCLK-----QQLDVG-RPFPH--TSKTTTAVYMFYLLSLLQ PKAGG-----------SRAQPPPSLRGLCSLAAAGLW-RQRILFDEDELRRHGLEAAH-V SAF--LNMNVFHKDIQ--RERYYSFIHL-SFQEFFAAMFYALEGELGAS----------- ----------------------------PAGL--TGL--LDHYAKCE-RSSLALAVRFLF GLLNEETRGYLDRRLGWRISP--RTKR-DLLRWIRAKAR--------------------- -----SEG---STL-Q-RGALELFTCLYEI-QEEDFIQRALDYFQVV------------- -----VVSEMA-TKMEHVASS-----FC-VRNCWSALVVHLCSA-PFSADGEQEPEGAEG PQNQP------LKP-SEKNILP-ETYCEHLAAALS-TNRN--LVELVLYRNALGDRGVRL L------CQGLRHP------NCQLQNLRLKRC-------------------RISAAACQD IAAALV------------------TNPNLIRLDLSRN-VLGA-AGVRLLAGGLLHPRCRL QMLQL-RRCHVDGEAC--QELSKVLSTS-QHL-AELDLT-GNALGESGLQLLCPGLG--H -SACKLQTLW-------------------------------------------------- -----------LKICHLTPAA----CQNLSSVLSTNQS-LTEL----------------- --------------------------------------------DLSLNDLGDAGVTSLC EGLCHSKSQLHTL----------------------------------------------- ---------RLGICRLTFVSCEALSTTLQSN-VHL------------------------- ------------------------------------------------------------ ---------------------------------------KALDVSFND-LEDMGVHLLCE G----------------------------------------------------------- --------------------------LQHPTCK--------------------------- -----------------------------------------------------------L QKL--WLDSCCLSGAACR-------------------------------------DLASA LGA---NQT---------------------------------LRELYLTNNA-LGDAGVQ LLCQRLS-----QASCR---LRTLW----L-FGTELTDGTQQALAALRGSKPHLDIGS-- ------------------------------------------------------ >C_familiaris_ENSCAFP00000010008 ------------------------------------------------------------ ------------------MTDGSSSSFFPDFGLLLYLEELNKEELNKFKSFLKNETVE-- ----P-RSC-QIPWVEVKKAKREDL-ANLMKKYYPG-EQAWDVALKIF-----GKMNLKD LCERATAE-----------------------------INWTARTMVTEGARTQEE--QD- ------------DQ---------------------------------------------- ----EAVQSD-------------------------------------------------- ----GTEYRIQIKEKFRIMWDKKCLFGGPEDFHPGIAQ---EDRE--------------- -------------LLEHLFDVDVKTGEQPQT--VVLQGAAGVGKTSLVR-KAIVDWAEGN LYQQKFSYVFYLNAREINQ-LRERS--FVQMISKD--WPSTEGPIERIMTQ-PSSLLFII DSFDELNFA------FE--EPDF----VLCEDWTQVHPVSFLMSSLLRKVMLPESFLLVT TRLTACKKLKPLLKNQHSVELLGMSKDARKEYIYQFFEDKK---------RASQVFSSLR SNEMLFSMCKVPLVCWAICTCLE-----QQIEMG-GDVSL--TCKTTTALFTRYISSLFP PVDGN----------CPSLPNQTQLKSLCHLAAKGVW-TMTSVFYREDLRKHGLTKSD-V SIF--LDMNILQKDTE--YENCYVFTHL-HVQEFLAAMFYMLRDNWETR--N-------- --------------------------NLFDSF--EDLKLLLESKSSK-DPHLMQMKCFLF GLLNEDLLKQLETTLKCRLSL--EIKG-KILQWLEILGN--------------------- -----IKC---FPA-E-LEFLELFLCLYET-QDEAFISQAMRSFQKV------------- -----VI-DVC-GKVHLLVSS-----FC-LKHCQCLQTIKLSVT-VVFE-KTLNSS---- -PPAE------MWQ-KDDG-SI-IHCWQDLCSVLH-TNEH--LRELDLCHSNLDELAMKT F------YQELRHP------NCKLQRLLMRFL-------------SF-----P--GGCQD IASSLT------------------HNQNLMHLDLKGS-DIGD-DGVKSLCEALKHPECKL QNLSL-ESCGLTTLCC--LNISKALIRS-QSL-RFLNLS-TNHLLDDGVKLLCEALG--H -PKCHLERLSLESCGL---TVAGCEDLSLALISNKRLTHLCLADNILGDDGVKLVNDALK HPQC-KLQSLVLRRCHFTSLS----SEHLSSALLCNKS-LIHL----------------- --------------------------------------------DLGSNWIQDDGIKLLC DAFRHPSCNLQDL----------------------------------------------- ---------ELMGCVLTSMCCLDLASAILNN-SHL------------------------- ------------------------------------------------------------ ---------------------------------------QNLDLGHND-LRDDGVKILCE A----------------------------------------------------------- --------------------------LRHPNCN--------------------------- -----------------------------------------------------------I QRL--GLEYCGLTSLCCQ-------------------------------------DLSYT LRS---NQN---------------------------------LIKINLKQNT-LGYEGMM KLCEVLK-----SPECK---LKVLG----V-CKEAFDEEAQKLLEAVRISNPHLI---IK RDYNDDDE-DGSWWRCP------------------------------------- >B_taurus_ENSBTAP00000002954 ------------------------------------------------------------ ------------------MTHLSSSSFFSDFGLLLYLEELNKEELIRFKSFLKNETLE-- ----P-RSC-RIPWSEVKKAKRKDL-ADLMSKYYPG-EQAWEVALSIF-----GKMNLKD LCQRAKAE-----------------------------INGTAQTMRTEDTEAREV--QG- ------------DQ---------------------------------------------- ----EAVLGD-------------------------------------------------- ----GAEYRIQIREKFRNMLDKNHLLGKSGDFCHEIAQ---EGRE--------------- -------------LLERLFGEEVGTEEQPQT--VVLQGAAGIGKTTLVR-MMMLDWAQGN LYQQKFTYVFYLNAREINQ-LRERS--FVQLLSKD--WPSTEGPIERIMSQ-PSRLLFII DSFDELNFA------FE--EPEF----VLCADWTQVHPVSFLMSSLLRKVMLPESSLLVT TKLTAWRKLKPLLKNRHSIQLLGMSEDARQEYIYQFFEDQS---------WALQVFSCLR NSVMLFNMCKVPAVCWVVCNCLE-----QQMEKG-ADITL--TCKTTTSLFACCISSLLT QVDRS----------FPGLPSQTQLRSLCHLAAKGVW-TMTYVFYKENLRRHGLVKSD-V SIF--LDTNILQKDTE--YENCYVFTHL-HIQEFFAAMFYVLEGNWDAR--D-------- --------------------------DSLQSF--ENLELVLESSSYK-DPHLSQMKCFLF GLLNEDRMKQLEETFNCTMSL--EVKW-TILQWMETLGS--------------------- -----SEQ---LPS-H-LVFLELFFHLYET-QDEVFVSQAMRYFQKV------------- -----VI-NIC-EEIHLLLSS-----FC-LKHCQCLRTMKLMVT-GVFEKKMLNSS---- -FPPE------TWQ-RAGS-HI-FHWWQDLCSVLH-TNKH--LREVILCHSNLDELAMKI F------NLELRHP------NCKLQKLRLRFT-------------SF-----P--DLCQG ISGSLT------------------HNQNLIHLDLKGS-DIGD-DGVKSLCEALKHPDCKL QSLSL-ESCDLTTVCC--LNISKALVRS-QSL-LSLNLS-TNNLLDDGVKLLCEGLM--H -PKCNLEKLSLESCGL---TVACCEDLSLVLISNKRLTHLCLADNMLGDGGVKFMSEALK HPQC-ILQSLVLRRCHFTSLS----SESLSASLLHNKS-LMHL----------------- --------------------------------------------DLGSNCLQDDGVKLLC DAFRHPSCSLQDL----------------------------------------------- ---------ELMGCVLTSACCLDLASAILNN-PNL------------------------- ------------------------------------------------------------ ---------------------------------------QSLDLGNND-LRDDGVKFLFE A----------------------------------------------------------- --------------------------LRHPNCN--------------------------- -----------------------------------------------------------I QRL--GLEHCGLTSLCCQ-------------------------------------DLSST LSS---NQG---------------------------------LIKISLTLNT-LQCEEIM KLSEVLR-----STECK---LQVLG----L-CKEALDEEAQKLLEAVASSNLRLA---VK QDCNDHEEEDGSWWRCF------------------------------------- >O_cuniculus_ENSOCUP00000008333 ------------------------------------------------------------ --------------------MLPAKLGGGLCRLSAYLEELEAVDLKKFKLYLGTAAEL-- ------GED-RIPWGRMETAGPLDV-AQLLVAHCGP-ERAWQLALRVF-----ERMHRRD LWERGQREHP-------------AGXXXXX----------XXXXXXX---XXXXXXXXXX X----------------------------------------------------------- ----XXXXXP-------------------------------------------------- ----REAYRDYVRRRFRLMEDRNARLGECVNLSHRYTRLLLVKEHSSPLRAQQMLLDMGR GHARSGGSQASPIRVEMLFEPDEERPEPPRT--VVLQGAAGMGKSMLAH-KVMLDWADGR LFQHRFDFLFYVNCREMNQAAPEQS--AQDLLASC--WPEAGAPLRELAHL-RGRLLLIL DGFDELKPS------FH--EARG----PWCRCWEEKRPTELVLSSLIQKKLLPELCLLIT TRPSALEKLQRLLEHPRHVEILGFPEAERKEYFLRYFQDAA---------QAAQAFGFVR DSEPLFTMCFVPMVCWVLCTCLK-----QQLEGG-GLLGQ--TSRTTTAVYTLYLLSLLQ PKPGT-----------PAPRPPPNQRGLCSLAADGLW-AQKVLFEERDLQRHGLDGAD-V SAF--LNMNIFQRDIN--CEKFYSFIHL-SFQEFFAAMHYALEGTEGGA----------- --------------------------GPDQNL--ARL--LAEYGFSE-RSFLALTVHFLF GLLSEETRSYLERTLCWKVSP--QVKE-ALLRAIQSKAR--------------------- -----SEG---STL-Q-AGSLEVFSCLYEI-QEEEFVQQALSHFQVV------------- -----VVGHIA-TKMEHMVSA-----FC-AKHCRSAVVLHLHGA-AYGMDADDGTGWT-G AQTPL------AEP-AERSILP-DAYSQPLAAALC-CCPD--LVELALYRNALGSRGLRL L------CQGLRHP------GCRLQNLRLKRC-------------------RIPSSACGD LATALT------------------ANRHLLRLDLSGN-SLGL-PGMELLCEGLRQPRCRL QMVQL-RKCLLDEGAC--RELASVLCTN-PHL-AELDLT-GNALEDAGVGRMCQGLR--H -PGCRLRT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >O_anatinus_ENSOANP00000014644 ------------------------------------------------------------ ------------------------MTCSIRSRLAEYLEELRDPELRKFKFHLEDLAPA-- ----A-GWA-PIPWGRTEKADSLDL-AHLLVAHVGE-RGAWELAVHVF-----ERIHRKD LWERARAEAE-------------VRGKSRQIIPGVLIVCRALSCLKRWRGLRLLYV---- ------------------------------------------------------------ ----PVYPDP-------------------------------------------------- ----RDVYREHIRRKFRFFEDRNARPGECVNLSQRYTQLLLMERHPTPRDAAPVSPTAQR EDAGAPERQPGPLQLETLLEPDASWPEPPRT--VVLRGAAGIGKSMLAR-KIMLDWADGL LYRARFDYLFYVSCREMSR-VGRGS--LAGLISGR--WPRREAPLADILRR-PERLLFVI DGFDELGRT----------------------PWKAKMPVAGLLGGLLGKDLLPEASLLIT TRPAALARLQPLLEQPRHAEILGFSRAGRRDYFRKFFGDGR---------QASRALGLVR DVEALSAVCFVPLVCWIVCTCLK-----QEMERG-EPPGQ--PSKTTTAVYVFYLLSLLR PDPGG-----------SGPRGRPVLAPLCSLAAHGIW-ARKVLFDEGDLSRHGLAGSD-V SAF--LNLSVFQKDIH--CQRLYSFVHR-SFQEFFAALFYLTDEGGREG----------- ------------------------GRGSRHSV--TRL--LEHYGRSE-TGYLALTVRFLF GLLNGENKSYLERQLGCPLSP--TVKG-ELLAWIEAGAR--------------------- -----IGG---RTL-E-RGALDLFSCLYET-QEEGFIVIV-------------------- ------ACDLS-TKMDHVISA-----FC-VGNCRNASVVHLGSE-EFSSEEAAEGQGP-- ---------------------------------------------VGMEGTHLGDILVII S------SSSTSIT------PCSVEKCWLPD------------------------TYCEH LSSALR------------------TNQNLAELVLDHN-ALGN-RGVKLLCQGLGHANCKL QNLGL-KKCRFSSAAC--QDISSALSAN-QNL-VMMDLS-NNALEDVGVKLNPPL----- -PFPLLPSLS-------------------------------------------------- -------HGHRLKKCYFSWAA----CEDLSSVLSTNPH-LMEL----------------- --------------------------------------------DLTGNALGDAGVQLLC VGMKQTSCRLKTL----------------------------------------------- ---------WLKICHLTRASCMELASVLSVD-CSL------------------------- ------------------------------------------------------------ ---------------------------------------TELDLSLND-LEDAGVRLLCE G----------------------------------------------------------- --------------------------LGQPKCK--------------------------- -----------------------------------------------------------L QKL--RYTRCFL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >O_cuniculus_ENSOCUP00000000403 ------------------------------------------------------------ ------------------MA-ASSSSYFSDFGLLLYLEELNKEEFNKFKLLLR-ETME-- ----P-GPC-LIPWTAVKKAKREDL-ANLMNRYYPG-EQAWSVTLKIF-----GKMNLRG LCERAKAE-----------------------------INRTATAMEQEDVEPREM--QG- ------------DQ---------------------------------------------- ----EAMLDS-------------------------------------------------- ----GTEYRIQIKEKFCIIWDESSWLGELETFHRAISQ---EDED--------------- -------------LVEHLFDMDVKTGEQPQI--VVLQGAAGVGKTKLAR-KAMLDWAKGN FY-QKFSYVFYLNGREMNQ-LKETS--FAQLISKD--WPSAESPIEKILSQ-PSGLLFII DSFDELNFA------FE--EPEF----ALCEDWTQVHPVSFLLSSLLRKVMLPESSLLLT MRLTSSKRLKNVLKSQRYVEIPGMPEQIRKEYIYQFFEDEE---------WGKKAFSLLR SNEMLFSMCRVPQVCWIACTCLK-----REMEKG-GDVTV--TCQTTTALFTSYISSLFT SVDEC----------CLSLPNQDQLGRLCHLAAKGIW-TMTHVFYRDNLRKHGLTKDD-V AIF--LDMNILQRDRE--YENCYVFTHL-HVQEFFAAMFYMLKDNWEAR--D-------- --------------------------YPVESF--EDLKLLLESKNDK-DSNLMQMRCFLF GLLNEKKIKQLEEALNCKTSM--DIKQ-ESLQWMEELGN--------------------- -----SDY---SPS-E-LGFLELFHHLYET-QDEAFIGQAMSYFPKI------------- -----DI-KMC-EKNHLLVTS-----FC-LKHCRCLQTIKLSVS-VIFEKKIVNSS---- -CPAK------TC---DED-LI-IRCWKDLCSVIH-TNEH--LKELNLCHSNLDELAMRI F------YQELSHP------NCKLQKLLLRFV-------------SF-----P--DGCLG ISNFLT------------------QNQHLMHLDLTGS-DIGD-PGVKALCEALKHPRCXX XXXXL-ESCDLTTVCC--LNISKALIRN-QSL-GFLNLS-TNNLLDDGVKLLCEALR--H -PKCPLERLSLESCGL---TEAGCEDLSLALITNTRLTHLCLTDNVLGDGGVKFMSDALQ HPQC-TLQSLVXXXXXXXXXX----XXXXXXXXXXXKS-LRHL----------------- --------------------------------------------DLALNFLQDEGAKLLC DVFRHPSCSLQDV----------------------------------------------- ---------XXXXXXXXXXXXXXXXXXXXXX-XXX------------------------- ------------------------------------------------------------ ---------------------------------------XXXXXXXXX-XXXXXXXXXXX X----------------------------------------------------------- --------------------------XXXXXXX--------------------------- -----------------------------------------------------------X XXX--XLAYCGLTSLCCR-------------------------------------DLSST LIS---NQR---------------------------------LRKINLTQNP-LGSEGIK KLCEVLR-----SPQCK---LQTLG----L-CKEAFDEEAQKLLEAVTLKNPHLV---IK PDYNDHNEDDGSWWQCFS------------------------------------ >G_gorilla_ENSGGOP00000004737 ------------------------------------------------------------ -----------------------MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQ-- ----K-GCI-PLPRGQTEKADHVDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LYEKAKRDEP-------------KWGSDNAHVSNPTVICREDSIEEEWMGLLEYLSRISI C----------------------------------------------------------- ----KMKKDY-------------------------------------------------- ----RKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK T--KTCESPVSPIKMEMLFDPDDEHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWASGT LYQDRFDYLFYIHCREVSL-VTQRS--LGDLIVSC--CPDPNPPIHKIVRK-PSRILFLM DGFDELQGA------FD--EHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEA---------QARAAFSLIQ QNEVLFTMCFIPLVCWIVCTGLK-----QQMESG-KSLAQ--TSKTTTAVYVFFLSSLLQ PRGGS-----------QEHRLCAHLWGLCSLAADGIW-NQKILFEESDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEEKEGRA---------- -----NVPGSR-------------LKLPSRDV--TVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTSYLEKKLSCKISQ--QIRL-ELLKWIEVKAK--------------------- -----AKK---LQI-Q-PSQLELFYCLYEM-QEEDFVQRAMDYFPKI------------- -----EI-NLS-TRMDHVVSS-----FC-IENCHRVESLSLGFL-HNMPKEEEEEEKE-- ------------------------------------------GRHLDMVQCVLPGSSHAA C------SHGLV--------NSHLXX-----------------------------XXXXX XXXXXX------------------XXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXX XXXXL-GRCGLSHECC--FDISLVLSSN-QKL-VELDLS-DNALGDFGIRLLCVGLK--H -LLCNLKKLX-------------------------------------------------- -----------XXXXXXXXXX----XXXXXXXXXXXXX-XXXX----------------- --------------------------------------------XXXXXXXXXXXXXXXX XXXXXXXXXXXXX----------------------------------------------- ---------XLVNSGLTSVCCSALSSVLSTN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------THLYLRGNT-LGDKGIKLLCE G----------------------------------------------------------- --------------------------LLHPDCK--------------------------- -----------------------------------------------------------L QVL--ELDNCNLTSHCCW-------------------------------------DLSTL LTS---SQS---------------------------------LRKLSLGNND-LGDLGVM MFCEVLK-----QQSCL---LQNL------------------------------------ ------------------------------------------------------ >E_caballus_ENSECAP00000018270 ------------------------------------------------------------ ----------------------MASSFFSDFGLLWYLGELKKDEFRKFKDFLKQEPLQ-- ----L-GLK-PIPWAEVRKATREGL-ANLLVKHYEE-QEAWNVTFSIF-----HKIHRKD LCEKAKKE---------------------------------------------------- ------------------------------------------------------------ ------ITGH-------------------------------------------------- ----TKTYQAHIQEKFNNMWFRESVTRIHDYFDQKTTQ---KERE--------------- -------------SLERLF-APKETGKQPRT--VVFKGIQGIGKTTFLI-KLMLAWAEGS LYQERFFYVFYFCCREMKQ-LTQTS--LAALISRD--WPNSHVPLTEIMSQ-PERLLFVI DSFEELKHN------LD--EPES----DLCSDWMEQRPVRVLLSSLLRKKMLPECSLLIA AAPVYPGEIEDRLVCPEIKTFLGFSESERKQYFCCIFQDRN---------RAMEAFSFVR ENEQLFCMCQIPTLCWIVCTCLK-----HEMERG-KDLAL--TCRRTTSLYTSFIFNLFT AKGTS----------CPDQQSQSQLKGLCSLAAEGMW-TDTFVFSEEDLRRNGLVDSD-I PTL--LDMKALQKYRE--CENSYLFIHV-CVQEFCAAMFYFLKSHIDHP--N-------- --------------------------PAVGCT--ETL--LFTYLKKV-KVHWIYLGCFMF GLLNEKEQQKLDAFFGFHLSQ--EIQQ-KFRQCVQRIGE--------------------- -----SEH---LQG-E-VDFLALCYCLFEM-QNEAFVKWAMALFQDV------------- -----TF-SIV-DSADLVTSA-----YC-LKHCSRLRKLWLSIQ-NVFKEENANNPTS-- -------------------NYS-FICWHHVCSVLT-TNEN--LTELQVSDSSLNESAFVT L------CNQLRHP------SCHLQKLWINNV-------------SF-------SAESWF FFEVLT------------------LSPDLKYLNLNGT-ALSR-KDVKLLCNALSNPKCNV EELLL-TNCCLSADDC--EAFTWVLNSN-NKL-KLLNVS-YNYL-DKGVPLLCKALR--H -PDCALEVLV-------------------------------------------------- -----------LGYCYLSGHC----WKSLSDALLCNKS-LVHL----------------- --------------------------------------------DLSANVLKYEELKLLC EALKQPSCQLQSL----------------------------------------------- ---------CLLKCCITARGCQDLASVLTSN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------TGLQIGYND-IEDVGAKLLCE A----------------------------------------------------------- --------------------------LTHPQCR--------------------------- -----------------------------------------------------------L ENL--GLGACKLTSACCE-------------------------------------DLSSA LTS---SKT---------------------------------LRRLNLSGNA-LDHGGVV VLCEALR-----CPECP---LQVLG----L-KKDEFDEETQRLLMAEEERNPHLT---IF S----------------------------------------------------- >P_pygmaeus_ENSPPYP00000011607 ------------------------------------------------------------ --------------------MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATEL-- ------GEG-KIPWGRMEKAGPLEM-AQLLITHFGP-EEAWRLALSTF-----ERMNRKD LWERGQREDL-------------VRDTPPG----------GPSSLGN---QSTCLLEVSL V----------------------------------------------------------- ----TPRKDP-------------------------------------------------- ----QETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGR GHARTVGHQASPIKIETLFEPDEERPEPPCT--VVMQGAAGIGKSMLAH-KVMLDWADGK LFQGRFDYLFYINCREMNQSATECS--MQDLISSC--WPEPSAPLQELIRV-PERLLFII DGFDELKPS------FH--DPQG----PWCLCWEEKPPTELLLNSLIRKKLLPELSLLIT TRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAE---------QAGQVFNYVR DNEPLFTMCFVPLVCWVVCTCLQ-----QQLEGG-GLLRQ--MSRTTTAVYMLYLLSLMQ PKPGA-----------PCLQPPPNQRGLCSLAADGLW-NQKILFEEQDLRKHGLDGAD-V SAF--LNMNIFQKDIN--CERYYSFIHL-SFQEFFAAMYYILDEGERGA----------- --------------------------GPDQDV--TRL--LTEYAFSE-RSFLALTSRFLF GLLNEETRSHLEKSLCWKVSP--HIKM-DLLQWIQSKAQ--------------------- -----SDG---STL-Q-QGSLEFFSCLYEI-QEEEFIQQALSHFQVI------------- -----VVSNIA-SKMEHMVSS-----FC-LKHCRSAQVLHLYGT-TYSADGEDRARCSAG VHTLL------VQL-PERTVLL-DAYSEHLAAALC-TNPN--LIELSLYRNALGSRGVKL L------CQGLRHP------NCKLQNLRLFGM-------------------DLNKMTHSR LAALRV------------------TKPYL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------DIGC-- ------------------------------------------------------ >P_troglodytes_ENSPTRP00000038834 ------------------------------------------------------------ ----------------------------------------------------KQMTLH-- ----L-ELK-QIPWTEVKKASREEL-ANLLIKHYEE-QQAWNITLRIF-----QKMDRKD LCMKVMRE---------------------------------------------------- ------------------------------------------------------------ ------RTGY-------------------------------------------------- ----TKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQ---EECD--------------- -------------HLDRLF-APKETGKQPRT--VIIQGPQGIGKTTLLM-KLMMAWSDNK IFRDRFLYTFYFCCRELRE-LPPTS--LADLISRE--WPDPAAPITEIVSQ-PERLLFVI DSFEELQGS------LN--EPDS----DLCGDLMEKQPVQVLLSSLLRKKMLPEASLLIA VKPVCPKELQDQVTISEIYQPRGFNESDRLVYFCCFFKDPK---------RAMEAFNLVR ESEQLFSICQIPLLCWILCTSLK-----QEMQKG-KDLAL--TCQSTTSVYSSFVFNLFT PEGAE----------GPTPQSQHQLKALCSLAAEGMW-TDTFEFCEDDLRRNGVVDAD-I PAL--LGTKILLKYGE--RESSYVFLHV-CIQEFCAALFYLLKSHLDHP--H-------- --------------------------PAVRCV--QEL--LVANFEKARRAHWIFLGCFLT GLLNKKEQEKLDAFFGFQLSQ--EIKQ-QFHQCLKSLGE--------------------- -----HGN---PQG-Q-VDSLAIFYCLFEM-QDPAFVKQAVNLLQEA------------- -----NF-HII-DNVDLVVSA-----YC-LKYCSSLRKLCFSVQ-NVFKKEDEHSSTS-- -------------------DYS-LVCWHHICSVLT-TSGH--LRELQVQDSTLSESTFVT W------CNQLRHP------SCRLQKLGINNV-------------SF-------SGQSVL LFEVLF------------------YQPDLKYLSFTLT-KLSR-DDIRSLCDALNYPAGNV KELGL-VNCHLSPIDC--EVLAGLLTNN-KKL-TYLNVS-CNQL-DTGVPLLCEALC--S -PDTVLVYLM-------------------------------------------------- -----------LAFCHLSEQC----CQYISEMLLHNKS-VRYL----------------- --------------------------------------------DLSANVLKDEGLRTLC EALKHPDCCLDSL----------------------------------------------- ---------CLVKCFITAAGCEDLASALISN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KILQVGCNE-IGDVGVQLLCR A----------------------------------------------------------- --------------------------LTHPDCR--------------------------- -----------------------------------------------------------L EIL--GLEECGLTSTCCK-------------------------------------DLASV LTC---SKT---------------------------------LQQLNLTLNT-LDRTGVV VLCEALR-----HPECA---LQVLG----L-RKTDFDEETQALLTAEEERNPNLT---IT DDCDTITRVEI------------------------------------------- >P_troglodytes_ENSPTRP00000019820 ------------------------------------------------------------ ----------------------MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEK-- ----F-ELK-PIPWAELKKASKEDV-AKLLDKHYPG-KQAWEVTLNLF-----LQINRKD LWTKAQEE-----------------------------MR--------------------- ------------------------------------------------------------ --------NK-------------------------------------------------- ----LNPYRKHMKETFQLIWEKETCLHVPEHFYKETMK---NEYK--------------- -------------ELNDAY----TAAARRHT--VVLEGPDGIGKTTLLR-KVMLDWAEGN LWKDRFTFVFFLNVYEMNS-IAETS--LLELLSRD--WPESSEKIEDIFSQ-PERILFIM DGFEQLKFN------L---QLKA----DLSDDWRQRQPMPIILSSLLQKKMLPESSLLIA LGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKS---------KALKVFNFVR DNGPLFILCHNPFTCWLVCTCVK-----QRLERG-EDLEI--NSQNTSYLYASFLTTVFK AGSQS----------FPPKVNRARLKSLCALAAEGIW-TYTFVFSRGDLRRNGLSESE-G VMW--VGMRLLQRRG-----DCFAFMHL-CIQEFCAAMFYLLKRPKDDP--N-------- --------------------------PAIGSI--TQL--VRASVVQP-QTLLTQVGIFMF GISTEEIVSMLETSFGFPLSK--DLKQ-EITQCLESLSQ--------------------- -----CEA---DRE-A-IAFQELFIGLFET-QEKEFVTKVMNFFEEV------------- -----FI-YIG-NIEHLVIAS-----FC-LKHCQHLTTLRMCVE-NIFPDDSGCISDYN- --------------------EK-LVYWRELCSMFI-TNKN--FQILDMENTSLDDPSLAI L------CKALAHP------VCKLRKL-FTSV-------------YF--------GHDSE LFKAVL------------------HNPHLKLLSLYGT-SLSQ-SDIRHLCETLKHPMCKI EELIL-GKCDISSEAC--EDIASVLACN-SKL-KHLSLV-ENPLRDEGMTLLCEALK--H -PHCALERLM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LMGCFLTSDSCKDIAAVLICN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGHNE-IGDTGVRQLCA A----------------------------------------------------------- --------------------------LQHPHCK--------------------------- -----------------------------------------------------------L ECL--GLQTCPITRACCG-------------------------------------DLAAA LIA---CKT---------------------------------LRSLNLDWIA-LDVDAVV VLCEALS-----HPDCA---LQMLG----L-HKSGFDEETQKILMSVEEKIPHLT---IS HGPWIDEEYKIRGVLL-------------------------------------- >H_sapiens_ENSP00000301295 ------------------------------------------------------------ ----------------------MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQ-- ----L-ELK-QIPWTEVKKASREEL-ANLLIKHYEE-QQAWNITLRIF-----QKMDRKD LCMKVMRE---------------------------------------------------- ------------------------------------------------------------ ------RTGY-------------------------------------------------- ----TKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQ---EECD--------------- -------------HLDRLF-APKEAGKQPRT--VIIQGPQGIGKTTLLM-KLMMAWSDNK IFRDRFLYTFYFCCRELRE-LPPTS--LADLISRE--WPDPAAPITEIVSQ-PERLLFVI DSFEELQGG------LN--EPDS----DLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIA IKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPK---------RAMEAFNLVR ESEQLFSICQIPLLCWILCTSLK-----QEMQKG-KDLAL--TCQSTTSVYSSFVFNLFT PEGAE----------GPTPQTQHQLKALCSLAAEGMW-TDTFEFCEDDLRRNGVVDAD-I PAL--LGTKILLKYGE--RESSYVFLHV-CIQEFCAALFYLLKSHLDHP--H-------- --------------------------PAVRCV--QEL--LVANFEKARRAHWIFLGCFLT GLLNKKEQEKLDAFFGFQLSQ--EIKQ-QIHQCLKSLGE--------------------- -----RGN---PQG-Q-VDSLAIFYCLFEM-QDPAFVKQAVNLLQEA------------- -----NF-HII-DNVDLVVSA-----YC-LKYCSSLRKLCFSVQ-NVFKKEDEHSSTS-- -------------------DYS-LICWHHICSVLT-TSGH--LRELQVQDSTLSESTFVT W------CNQLRHP------SCRLQKLGINNV-------------SF-------SGQSVL LFEVLF------------------YQPDLKYLSFTLT-KLSR-DDIRSLCDALNYPAGNV KELAL-VNCHLSPIDC--EVLAGLLTNN-KKL-TYLNVS-CNQL-DTGVPLLCEALC--S -PDTVLVYLM-------------------------------------------------- -----------LAFCHLSEQC----CEYISEMLLRNKS-VRYL----------------- --------------------------------------------DLSANVLKDEGLKTLC EALKHPDCCLDSL----------------------------------------------- ---------CLVKCFITAAGCEDLASALISN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KILQIGCNE-IGDVGVQLLCR A----------------------------------------------------------- --------------------------LTHTDCR--------------------------- -----------------------------------------------------------L EIL--GLEECGLTSTCCK-------------------------------------DLASV LTC---SKT---------------------------------LQQLNLTLNT-LDHTGVV VLCEALR-----HPECA---LQVLG----L-RKTDFDEETQALLTAEEERNPNLT---IT DDCDTITRVEI------------------------------------------- >P_pygmaeus_ENSPPYP00000011693 ------------------------------------------------------------ ----------------------MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLH-- ----L-ELK-QIPWTEVKKASREEL-ANLLIKHYEE-QQAWNITLRIF-----QKMDRKD LCMKVMRE---------------------------------------------------- ------------------------------------------------------------ ------RTGY-------------------------------------------------- ----TKTYQAHAKQKFSHLWSSKSVTEIHLYFEEEVKQ---EECD--------------- -------------HLDRLF-APKETGKQPRT--VVIQGPQGIGKTTLLM-KLMMAWSDNK IFRDKFLYTFYFCCRELRE-LAPMS--LADLISRE--WPDPAAPITEIVSQ-PERLLFVI DSFEELKGG------LN--EPDS----DLCGDLMEKRPVQVLLSSLLRRKMLPEASLLIA VKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPK---------RAMEAFNLVR ESEQLFSICQIPLLCWILCTSLK-----QEMQKG-KDLAL--TCQSTTSVYSSFVFNLFT HEGAE----------GPTPQSQHQLKALCSLAAEGMW-TDTFEFCEDDLRRNGVIDAD-I PVL--LGTKILLKYGE--RESSYVFLHV-CIQEFCAALFYLLKSHLDHP--H-------- --------------------------PAVRCV--QEL--LVANFEKARRAHWIFLGCFLT GLLNKKEQEKLDAFFGFQLSQ--EIKQ-QFHQCLKSLGE--------------------- -----RGQ---PQG-Q-VDSLAIFYCLFEM-QDPAFVKQAVNLLQEA------------- -----KF-HII-DNADLVVSA-----YC-LKYCSSLRKLCFSVQ-NVFEKEDEHSSTS-- -------------------DYS-LICWHHICSVLT-TSGH--LRELQVQDSTLSESTFVT W------CNQLRHP------SCRLQKLGINNV-------------SF-------SGQSAL LFEVLF------------------YQPDLKYLSFTLT-KLSR-DDIRCLCDALNYPAGNV KELGL-VNCHLSPIDC--EVLAGLLTNN-KKL-TYLNVS-CNQL-DTGVPLLCEALC--S -PDTVLVYLM-------------------------------------------------- -----------LAFCHLSEQC----CEYISEMLLRNKS-VRYL----------------- --------------------------------------------DLGANVLKDEGLKTLC EALKRPDCCLDSL----------------------------------------------- ---------CLVKCFITAAGCEDLASALINN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KILQIGCNE-IGDVGVQLLCR A----------------------------------------------------------- --------------------------LTHPDCR--------------------------- -----------------------------------------------------------L EIL--GLEECGLTSACCK-------------------------------------DLASV LTC---SKN---------------------------------LQQLNLTLNA-LDHTGVV ALCEALR-----HPECA---LQVLG----L-RKTDFDEETQALLTAEEERNPNLT---IT DDCDTITRVEI------------------------------------------- >P_pygmaeus_ENSPPYP00000004673 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------D-------------------------------------------------- ----GTEYRIRIKEKFCITWDKKSLAGKPEDFHHGIAE---KDRK--------------- -------------LLEHLFDVDVKTGEQPQV--VVLQGAAGVGKTTLVR-KAMLDWAEGN LYQQRFKYVFYLNGREINQ-LKERS--FAQLISKD--WPSTE-PIEEIISQ-PSSLLFII DGFDELN-A------FE--EPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT TRLTTSKRLKQLLKNHRYVELLGMSEDAREEYIYQFFEDKR---------WAMKVFSSLK SNEMLFSMCQVPLVCWATCTCLK-----QQMEKG-GDVTL--TCQTTTALFTCYISSLFT PVDGR----------SLSLPNQAQLRRLCQVAAKGIW-TMTYVFYRENLRRLGLTKSD-V SSF--MDSNIIKKDAE--YENCYVFTHL-HV-EFFAAMFYMLKGNWEAW--N-------- --------------------------PSCQPF--EDLKSLLQ-TSYK-DPQLTQMKCFL- GLLNEDRVKQLERTFNCKMSL--KIKS-KLLQCMEVLGN--------------------- -----SDY---SPS-Q-LGFLELFHYLYET-QDKAFISQAMRYFPKV------------- -----AI-NIC-EKIDLLVSS-----FC-LKHCRCLRTIRLSVT-GVFEKKILKTS---- -LPTN------TW---DGD-RI-THCWQDLCSVLH-TNEH--LRQLDLCHSNLDKSAMNI L------HHELRHP------NCKLQKLLLKFI-------------TF-----P--DGCPD ISTSLI------------------HNKNLMHLDLKGS-DIGD-NGVKSLCEALKHPECKL QTL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000031420 ------------------------------------------------------------ ----------------------MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLH-- ----L-ELK-QIPWTEVKKASREEL-ANLLIKHYEE-QQAWNITLRIF-----QKMDRKD LCMKVMRE---------------------------------------------------- ------------------------------------------------------------ ------RTGY-------------------------------------------------- ----TQTYQAHAKRKFSRLWSSKSVTEIHLYFQEEVKQ---EECE--------------- -------------HLDHLF-APKETGKQPRT--VIIQGPQGIGKTTLLM-KLLMAWSDNK IFRDRFLYTFYFCCRELRE-LPATS--LADLISRE--WPDPAAPVTEIVSQ-PERLLFVI DSFEELKDG------LN--EPDS----ALCDDVMEKRPVQVLLSSLLTKKMLPEASLLVA VQPVCPKELRDRVPISEIYQPRGFNESDRLVYFCCFFKDPK---------RAMEAFSLVR ESEQLFSICQIPLLCWILCTSLK-----QEMQKG-KDVTL--TCQSTTSVYSCFIFNLFT PEGAE----------GPTPQSQRQLKALCFLAAEGMW-TDTFEFREDDLRRNGVVEAD-I PAL--LGTKVLLKYGE--RESSYVFLHA-CIQEFCAALFYLLKSHLDHP--H-------- --------------------------PAVRSV--QEL--LVANFEKTRRAHWIFLGCFLT GLLNKQEQQKLDAFFGFQLSQ--EIKQ-QLHQCLKSLGE--------------------- -----HSD---PLG-Q-VDSLAIFYCLFEM-QDPAFVKQAVNLLQKA------------- -----DF-HII-DNADLVVSA-----YC-LKYCSSLRKLSFSVQ-NVFKKEDEHSSTS-- -------------------DYS-LVCWHHICSVLT-TSGH--LTELQVQDSTLSESTFVT W------CNQLRHP------SCRLQRLGINNV-------------SF-------SDPSGQ LFEVLF------------------YQPDLKYLSFTLT-KLSR-DDVRSLCDALNYPAGNV KELAL-VDCFLSPIDC--EVLACLLTNN-KKL-TYLNVS-CNDL-DAGLPLLCEALC--N -PDTVLVYLM-------------------------------------------------- -----------LAYCHLGEQC----CEYISEMLLHNKS-VRYL----------------- --------------------------------------------DLGANVLKDEGLKTLC EALKRPDCRLDSL----------------------------------------------- ---------CLVKCFITVAGCEDLASVLISN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KILQIGCNE-IGDVGVKLLCG A----------------------------------------------------------- --------------------------LKHPNCR--------------------------- -----------------------------------------------------------L EVL--GLEECGLTSACCK-------------------------------------DLASV LTS---SKT---------------------------------LQQLNLTLNA-LDYAGVV VLCEALR-----HPECA---LQVLG----L-RKTDFDEETQALLMAEEERNPNLT---IT DDCDTVTGVEI------------------------------------------- >E_caballus_ENSECAP00000017692 ------------------------------------------------------------ ----------------------MVPSGQLDFNLQPLLERLDQDELSQFKSLLRTLSLQ-- ----D-ELQ-HIPQTEVEEASGKQL-AEILTNQCPR-NWVEMVTIQVF-----DKMNRTD LSERAKDEFK--ALKSLQENKPPSLGKSST---------DSPLHYP-------------- ------------------------------------------------------------ ----IQKKGW-------------------------------------------------- ----QEKI-----QKFCQIWEKNFWPGASENVH-IVTQ----RYE--------------- -------------TLIPFCNPKMLTGPFPHT--VVLHGPAGIGKTTLAK-KLMLDWTQDN LAE-TFNAAFYLSCKELNH-KGACT--FAELISKN--WPDLQDAIPEIFAQ-AQKVLFII DGFDELRVP------SG--ALIH----DMCCDWQKQKPVPVLLGSLLKRKILPKATLLIT TRPGTLRELRLLVEQPLFIEIEGFLELDRKAYFLKHFEEEV---------QALRAFDLMK SNAALFHLGSAPAVCWIVCTCMK-----LQMEKG-EDPAP--TCQTITSLFLHFLCSH-- ---------------CPGPFLQVPVTALCLLAAGGIW-TQTSMFDGEDLERLGVKESD-F HPF--LDKNILQKGKD--CEGCYSFIHL-SVQQFLAALFYVLEREEEED--G-------- ---------DS-------------CRWDIGGV--QKL--LSKEERLK-NPSLTHVGYFLF GLLNEKRARELETTFGCQVSL--KIKQ-ELLECRVKSTE--------------------- -----NKP---L-S-V-TEMQEVLYCLYES-QEERLVKDAMAHIKET------------- -----SL-HLK-NKMDIIHAS-----FC-LQHCRNLQKISLQVE-KGVFLENDTASESDT QVESCGMWDA-ASA-FQNDEHV-LPFWMGLCSIFG-SNKN--LIFLDISQSFLSTSSVKI L------CEKIASA------TCNLQKVVLKNI-------------SP-----A--DAYQN FCITFG------------------GHKTLTHLTLQGN-DQDD--MFPSLCSVLRHPKCHL QYLSL-VSCSATTHQW--ADLSSSLEIN-QSL-TCLNLT-ANELLDEDAKLLYMTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCHLTEAS----CKELSSALIVNQR-LTHL----------------- --------------------------------------------CLAKNALGDGGVKLLC EGLSYPECQLQTL----------------------------------------------- ---------VLWYCNITSDGCNHLSTLLQQN-SSL------------------------- ------------------------------------------------------------ ---------------------------------------MHLDLGLNH-IGIIGLKFLCE A----------------------------------------------------------- --------------------------LKKPLCN--------------------------- -----------------------------------------------------------L RCL--WLWGCAITPFSCE-------------------------------------DLSSA LSS---NQN---------------------------------LTTLDLGQNS-LGYSGVK VLCDALK-----LQSCP---LQTLR----L-KIDESDARIHKLLKEIKDSNPQLT---IE ------------------------------------------------------ >M_mulatta_ENSMMUP00000007829 ------------------------------------------------------------ -----------------------MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQ-- ----K-GCI-SLPRGQTEKADHVDL-ATLMIDFNGE-EKAWAMAVWIF-----AAINRRD LYEKAKRDEP-------------KWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI C----------------------------------------------------------- ----KKKKDY-------------------------------------------------- ----CKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREHELLAIGK T--KTWESPVSPIKMELLFDPDDEHSEPVHT--VVFQGAAGIGKTILAR-KIMLDWASGT LYQDRFDYLFYIHCREVSL-VTQRS--LGDLIMSC--CPDPNPPIRKIVSK-PSRILFLM DGFDELQGA------FD--EHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLIT TRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEA---------QARAAFSLIQ ENEVLFTMCFIPLVCWIVCTGLK-----QQMESG-KSLAQ--TSKTTTAVYTFFLSSLLQ PRGGS-----------QEHRLCAHLWGLCSLAADGIW-NQKILFEESDLRNHGLQKAD-V SAF--LRMNLFQKEVD--CEKFYSFIHM-TFQEFFAAMYYLLEEEKEGRT---------- -----NVPGSC-------------LKLPSRDV--TVL--LENYGKFE-KGYLIFVVRFLF GLVNQERTCYLEKKLSCKISQ--QIRL-ELLKWIEVKAK--------------------- -----AKK---LQI-Q-PSQLELFYCLYEM-QEEDFVQRAMDYFPKI------------- -----EI-NLS-TRMDHVVSS-----FC-IENCHRVESLSLGFL-HNMPKEEEEEEKE-- ------------------------------------------GRHLDMVQCVLPG-SHAA C------SHR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >P_pygmaeus_ENSPPYP00000011694 ------------------------------------------------------------ ----------------MNFSVITCPNGGTNQGLLPYLIALDQYQLEEFKLCLEPQQLMDF WSAPQGHFP-RIPWANLRAADPLNL-SFLLDEYFPK-GQAWKVILGIF-----QTMNLTS LCEKVRTK-----------------------------MRENVQTQELQDPTQEDVEMLEA AAGNMQTQGCQDPNQEELEELEEETGNVQAQRCQDPNQEEPEM----------------- ----LEEADH-------------------------------------------------- ----RRKYREKMKAELLETWDNINWPKDHVYI-RNTSK---DEHE--------------- -------------ELQRLLDPN-RTRAQAQT--IVLVGKAGVGKTTLAM-QAMLHWANGV LFQQRFSYVFYLNCHKIRY-MKETT--FAELISLD--WPDFDAPIEEFMSQ-PEKLLFII DGFEEIIIS------ES--RSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLIT IKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRNFDDLS---------EVEKILQQIR KNETLFDSCSVPMVCWTVCSCLK-----QPKVRY-YDLQS--ITQTTTSVYAYFFSNLFS RAEVD----------LADDSWPGQWRALCSLAIEGLW-SMNFTFNKEDTEIEGLEVPF-I DSL--YEFNILQKIND--CGGCTTFTHL-SFQEFFAAMFFVLEEPREFP--P-------- ------------------------HSTKPQEM--KML--LQHVLLDK-EAYWTPVVLFFF GLLNKNIARELEDTLHCKISP--RVME-ELLKWGEELGK--------------------- -----AES---ASL-Q-FHILRLFHCLHES-QEEDFTKKMLGHIFEV------------- -----DL-NIL-EDEELQASS-----FC-LKHCKRLNKLRLSVS-SHILERDLE------ -----------ILE-TSKFDSR-MHAWNSICSTLV-TNEN--LHELDLSNSKLHGSSVKG L------CLALKNP------RCKVQKLTCKSV-------------TP-----E--WVLQD LIIVLQ------------------GNSKLTHLNFSSN-KLGM--TVPLILKALRHSACNL KYLCL-EKCNLSAASC--QDLALFLTSI-QHV-TRLCLG-FNRLQDDGIKLLCAALT--H -PKCALERLE-------------------------------------------------- -----------LWFCQLGAPA----CEHLSDALLQNRS-LMHL----------------- --------------------------------------------NLSKNSLRDEGVKFLC EALGHPDCNLQSL----------------------------------------------- ---------NLSGCSFTREGCRELANALRHN-HNV------------------------- ------------------------------------------------------------ ---------------------------------------KILDLGEND-LQDDGVKLLCE A----------------------------------------------------------- --------------------------LKPSHRA--------------------------- -----------------------------------------------------------L HTL--GLAKCNLTTACCQ-------------------------------------HLFSV LSS---SKS---------------------------------LVNLNLLGNE-LDPDGVK MLCKALR-----KSTCR---LQKLG----------------------------------- ------------------------------------------------------ >P_pygmaeus_ENSPPYP00000011689 ------------------------------------------------------------ ----------------------MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEK-- ----F-ELK-PIPWAELKKASKEDV-AKLLDKHYPG-KQAWEVTLNLF-----LQINRKD LWTKAQEE-----------------------------MR--------------------- ------------------------------------------------------------ --------NK-------------------------------------------------- ----LNPYRKHMKEKFQLIWEKETCLHVPEHFYKETMK---NESK--------------- -------------ELNDAY----TAAARRHT--VVLEGPDGIGKTTLLR-KVMLDWAEGN LWKDRFTFVFFLNVYEMNG-VAETS--LLELLSRD--WPESSEKIEDIFSV-PERILFIM DGFEQLKFN------L---QLKA----DLSDDWRQRQPMPIILSSLLQKKMLPESSLLIA LGRLAMQKHYFMLRHPKLIKLLGFTESEKKSYFSYFFGEKS---------KAVKVFNFVR ESGPLFILCHNPFICWLVCTCVK-----QRLERG-EDLEI--NSQNTTSLYASFLTTVFR AGSQS----------FPPKVNRARLKSLCALAAEGIW-TYTFVFSHGDLRRNGLSESE-G LMW--VDMRLLQRRG-----DCFAFIHL-CIQEFCAAMFYLLKRPKDDP--N-------- --------------------------PAIGSI--TQL--VRASVVQP-QTLLTQVGIFMF GISTEEIVSMLETSFGFPLSK--DLKQ-EITQCLESLSQ--------------------- -----CEA---DRE-A-IGFQELFIGLFET-QEKEFVTKVMNFFEEV------------- -----FI-YIG-NIEHLVIAS-----FC-LKHCRHLTTLRMCVE-NIFPDDSGCISE--- ------------------------------------------------------------ ----------------------------FTSV-------------YF--------GHDSE LFKAVL------------------HNPHLKLLSLYGT-SLSQ-SDIRHLCETLKHPMCKI EELIL-GKCDISSEAC--EDIAFVLACN-SKL-KHLSLV-ENPLRDEGMTLLCEALK--H -PHCALERLM-------------------------------------------------- -----------LMYCCLTSVS----CDSISQVLLCSKS-LSLL----------------- --------------------------------------------DLGSNALEDNGVASLC GALKHPGCSIQEL----------------------------------------------- ---------WLMGCFLTSDSCKDIAAVLICN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGHNE-IGDTGVRQLCA A----------------------------------------------------------- --------------------------LQHPNCK--------------------------- -----------------------------------------------------------L ECL--GLQTCPITRACCG-------------------------------------DLAAA LIA---CKT---------------------------------LRSLNLDWIT-LDADAVV VLCEALS-----HPDCA---LQLLG----L-HKSGFDEETQKILMSVEEKIPHLT---IS HGPWIDEEYKIRGVLL-------------------------------------- >M_mulatta_ENSMMUP00000022013 ------------------------------------------------------------ ----------------MSFSVTTWADSGTNQGLLPYLVALDQYQLEEFKLCLEPQQLMDF WSAPQGHFP-HIPWANLRAADPFNL-SFLLEEHFPN-GQAWKVVLGVF-----QTMNLTS LCEEVRAK-----------------------------MKGNVQTQELQGPTQEDVEMLEA AAGNMQTQGCQDPNQEEPEEPEEETGNVQVQGCQDLNQEEPEM----------------- ----LEEADH-------------------------------------------------- ----RRKYREKMTAKLLETWDKIDWPKDHVYI-RNTSE---GEHE--------------- -------------ELQRLLDPK-RTRTQAQT--IVVVGRAGVGKTTLAM-QAMLHWANGV LFQEKFSYVFFLSCHKIRY-MKETS--FAELISLD--WPDSDAPIEEFMSQ-PEKLLFII DGFEEIIIS------EP--SSESLNDGSPCTDWYQELPVTKILLSLVKKELVPLATLLIT IKNCFVIDLKPSLVNPCFVQITGFTEEDLWVYFMRHFEDSR---------EVEKILQQIR KNENLFHSCSAPMVCWTVCSCLK-----LSKVRY-YDLQS--ITQTTTSLYAYFFSNLFS TAEVD----------LADESWPGQWRALCNLAMEGLW-SINFTFDREDTELEGLEVPF-I DCL--YKFNIIQKGND--CRGCITFTHL-SFQEFFAAMSFVLEEPRELL--P-------- ------------------------HSTKPQEM--KIL--LRDVLLNK-EAYWTPVVLFFF GLFKKNLARELEDTLHCKMSP--RVME-ELLKWGEELGK--------------------- -----AES---ASL-Q-FHVLQLFHCLHES-QEEDLAKKMLGHIFEV------------- -----DL-NIP-GDEELQASS-----FC-LKHCKRLNKLRLSVS-SHILERDLE------ -----------ILE-TSEVDSR-MHAWNSICSTLV-TNEN--LHELDLSNSKLHASSVKG L------CLALKNP------RCKVQKLTCKSV-------------TP-----E--WVLQD LIPVLQ------------------GNSKLTHLNFSSN-KLGA--TVPLILKALKHSACNL KYLCL-EKCSLSAASC--QDLALFLTSI-QHI-TRLCLG-FNQLQDDGIRLLCAALT--H -PKCALERLE-------------------------------------------------- -----------LWFCQLGAPS----CRYLSDALLQNRS-LAHL----------------- --------------------------------------------NLSKNRLGDEGVKFLC EALGRPDCNLQSL----------------------------------------------- ---------NLSGCSFTREGCRELANALKHN-HNV------------------------- ------------------------------------------------------------ ---------------------------------------KILDLGQND-LQDDGVKLLCE A----------------------------------------------------------- --------------------------LKPSHRA--------------------------- -----------------------------------------------------------L HTL--GLAKCNVTTACCQ-------------------------------------HLSSV LSS---SKS---------------------------------LVNLNLLGNE-LDHDGVK MLCKALR-----KSTCR---LQKLG----------------------------------- ------------------------------------------------------ >E_caballus_ENSECAP00000014445 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------FHYSITQ----RSQ--------------- -------------KFITFLNPQISTQLMPLT--VVLHGPAGVGKTTLAK-KWMVDWTQDN HAK-TFNSTFYLSCKELNH-KGECS--FADLLSKN--WPDLQDAVPEILTQ-AQKILFII DGFEELRVP------SE--ALIH----DMCCDWQKQKPVPVLLGSLLKRKMLPKATLLIT TRPGALRELGLLVEQPFFIEIEGFLELDRKAYFLKHFEEEA---------QALRAFDLMK SNAALFHLGSAPAVCWIVCTCMK-----LQMEKG-EDPAP--TCQTITSLFLHFLCSQFT SPPGS----------CPGPFLQVPVTALCLLAAEGIW-TQTSMFDGEDLERLGVKESD-F HPF--LDKNILQKGKD--CEGCYSFIHL-SVQQFLAALFYVLEREEEED--G-------- ---------DS-------------CRWDIGGV--QKL--LSKEERLK-NPSLTHVGYFLF GLLNEKRAGELETTFGCQVSR--KVKQ-ELLEFRVKSNK--------------------- -----NKR---LSS-V-TDMKEVLYCLYES-QEEQLVKNAMSYVKEI------------- -----SI-HLT-NTFEMMQSS-----FC-LKHCENLQKISLQVE-KGIFLENDTESELD- ---------------AQCDHRS-LPLWTDLCSVFS-SNKN--LSFLDVSQSFLSHSSVRI L------CEQITRV------TCHLQKVVIKNI-------------SP-----S--DAYRD LCLAFI------------------GKKTLTHLILEGD-VHTDKMLLLLLCEMLKHSRCNL QYLRL-GSCCDAAQKW--DDSSLALGIN-QSL-RCLDLT-ASELLDEGVKLLCTTLR--H -PKCFLQKLS-------------------------------------------------- -----------LENCHLTEAC----CKELSSTLIVNQR-LTYL----------------- --------------------------------------------CLANNKLGDGGVKLLC EGLSYPECQLQTL----------------------------------------------- ---------VLWHCNITRRGCKLISKLLQGD-SSL------------------------- ------------------------------------------------------------ ---------------------------------------TNLDLGLNP-IA-TGLWFLCE A----------------------------------------------------------- --------------------------LKKPNCN--------------------------- -----------------------------------------------------------L KYL--GLWGCSITPSCCQ-------------------------------------GLASA LIS---NQR---------------------------------LETLDLGQNV-LGKNGIM MLFEALK-----QNDGP---LKTLR----L-KVDESSVEVQKLLKDVKDSNPKLT---IE CNNARTT--RSSCCDFFS------------------------------------ >H_sapiens_ENSP00000263437 ------------------------------------------------------------ ----------------------MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLA-- ----H-ELQ-KIPHKEVDKADGKQL-VEILTTHCDS-YWVEMASLQVF-----EKMHRMD LSERAKDEVREAALKSFNKRKPLSLGITRK-ERPPLDVDEMLERFKTEAQAFTETK-GNV ICLGKEVF--K------------------------------------------------- ----GKKPDK-------------------------------------------------- ----DNRCRYILKTKFREMWKS--WPGDSKEVQ-VMAE----RYK--------------- -------------MLIPFSNPRVLPGPFSYT--VVLYGPAGLGKTTLAQ-KLMLDWAEDN LIH-KFKYAFYLSCRELSR-LGPCS--FAELVFRD--WPELQDDIPHILAQ-ARKILFVI DGFDELGAA------PG--ALIE----DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVT TRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQTSVLHREDLERLGVQESD-L RLF--LDGDILRQDRV--SKGCYSFIHL-SFQQFLTALFYTLEKEEEED--R-------- ---------DG-------------HTWDIGDV--QKL--LSGVERLR-NPDLIQAGYYSF GLANEKRAKELEATFGCRMSP--DIKQ-ELLRCDISCKG--------------------- -----GHS-----T-V-TDLQELLGCLYES-QEEELVKEVMAQFKEI------------- -----SL-HL--NAVDVVPSS-----FC-VKHCRNLQKMSLQVI-KENLPENVTASESDA E----------VER-SQDDQHM-LPFWTDLCSIFG-SNKD--LMGLAINDSFLSASLVRI L------CEQIASD------TCHLQRVVFKNI-------------SP-----A--DAHRN LCLALR------------------GHKTVTYLTLQGN-DQDD--MFPALCEVLRHPECNL RYLGL-VSCSATTQQW--ADLSLALEVN-QSL-TCVNLS-DNELLDEGAKLLYTTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCHLTEAN----CKDLAAVLVVSRE-LTHL----------------- --------------------------------------------CLAKNPIGNTGVKFLC EGLRYPECKLQTL----------------------------------------------- ---------VLWNCDITSDGCCDLTKLLQEK-SSL------------------------- ------------------------------------------------------------ ---------------------------------------LCLDLGLNH-IGVKGMKFLCE A----------------------------------------------------------- --------------------------LRKPLCN--------------------------- -----------------------------------------------------------L RCL--WLWGCSIPPFSCE-------------------------------------DLCSA LSC---NQS---------------------------------LVTLDLGQNP-LGSSGVK MLFETLT-----CSSGT---LRTLR----L-KIDDFNDELNKLLEEIEEKNPQLI---ID TEKHHPWAERPSSHDFMI------------------------------------ >B_taurus_ENSBTAP00000006201 ------------------------------------------------------------ ----------------------MAESFFSDFGLLWYLEELKKEEFWKFKELLKQEPLK-- ----L-KLK-PIPWTELKKASRENV-SKLLSKHYPG-KLAWDVTLNLF-----LQISRDD LWRKARNE-----------------------------IR--------------------- ------------------------------------------------------------ --------QK-------------------------------------------------- ----INPYRSHMKQKFQVLWEKEPCLLVPEDFYEETTK---IEYE--------------- -------------LLSTVYLDAFKPGESSPT--VVLHGPEGIGKTTFLR-KVMLEWAKGN LWRDRFSFVFFLTGREMNG-VTDMS--LVELLSRD--WPESSEPIEDIFSQ-PERILFIL DGMEELKFD------L---DCNA----DLCEDWEQPQSMQVVLQSLLQKQMLPECSLLLA LSKMGMRKNYSLLKHMKCIFLLGFSEHQRKLYFSHYFQEKD---------ASSRAFSFVR EKSSLFVLCQSPFLCWLVCTSLK-----CQLEKG-EDLEL--DSETITGLYVSFFTKVFR SGSET----------CPLKQRRARLKSLCTLAAEGMW-TCTFLFCPEDLRRNGVSESD-T SMW--LDMKLLHRSG-----DCLAFIHT-CIQEFCAAMFYMFTRPKDPP--H-------- --------------------------SVIGNV--TQL--ITRAVSEH-YSRLSWTAVFLF VFSTERMTHRLETSFGFPLSK--EIKQ-EITQSLDTLSQ--------------------- -----CDP---NNV-M-MSFQALFNCLFET-QDPEFVAQVVNFFKDI------------- -----DI-YIG-TKEELIICA-----AC-LRHCHSLQKFHLCME-HVFPDESGCISNTI- --------------------EK-LTLWRDVCSAFT-ASED--FEILNLDNCRFDEPSLAV L------CRTLSQP------VCKLRKFVCNFA-------------SN-----L--ANSLE LFKVIL------------------HNPHLKHLNFYGS-SLSH-MDARQLCEALKHPMCNI EELML-GKCDITGEAC--EDIASVLVHN-KKL-NLLSLC-DNALKDDGVLVLCEALK--N -PDCALEALL-------------------------------------------------- -----------LSHCCFSSAA----CDHLSQVLLYNRS-LTFL----------------- --------------------------------------------DLGSNVLKDEGVTTLC ESLKHPSCNLQEL----------------------------------------------- ---------WLMNCYFTSVCCVDIATVLIHS-EKL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNNK-IYDAGAKQLCK A----------------------------------------------------------- --------------------------LKHPKCK--------------------------- -----------------------------------------------------------L ENL--GLEACELSPASCE-------------------------------------DLASA LTT---CKS---------------------------------LTCVNLEWIT-LDYDGAA VLCEALV-----SLECS---LQLLG----L-NISSYDEEIKMMLTQVEEMNPNLI---IS HHLWTDDEGRRRGILV-------------------------------------- >P_troglodytes_ENSPTRP00000039083 ------------------------------------------------------------ ----------------------MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLA-- ----H-ELQ-KIPHKEVDKADGKQL-VEILTSHCDS-YWVEMASLQVF-----EKMHRMD LSERAKDEVREAALKSFNKRKPLSLGITRK-ERPPLDVDEMLERLKTEALAFPETK-GNV ICLGKDVF--K------------------------------------------------- ----GKKPDK-------------------------------------------------- ----DNRCRYILKTKFREMWKS--WPGDSKEVQ-VMAE----RYK--------------- -------------MLIPFSNPRVLPGPFSYT--VVLYGPAGLGKTTLAQ-KLMLDWAEDN LIH-KFKYAFYLSCRELSR-LGPCS--FAELVFRD--WPELQDDIPHILAQ-ARKILFVI DGFDELGAA------PG--ALIE----DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVT TRPRALRDLRILAEEPIYVRVEGFLEEDRRAYFLRHFGDED---------RAMRAFELMR SNADLFQRGSAPAVCWIVCTTLK-----LQMEKG-EDPVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQTSVLHREDLERLGVQESD-L RLF--LDGDILRQDRV--SKGCYSFIHL-SFQQFLTALFYALEKEEEED--R-------- ---------DG-------------HTSDIGDV--QKL--LSGVERLR-NPDLIQAGYYYF GLANEKRAKELEATFGCRMSP--DIKQ-ELLRCDISCKG--------------------- -----GHS-----T-V-TDLQELLGCLYES-QEEELVKEVMAQFKEI------------- -----SL-HL--NAVDVVPSS-----FC-VKHCRNLQKMSLQVI-KENLPENVTASESDA E----------VER-SQDDQHM-LPFWTDLCSIFG-SNKD--LMGLAINDSFLSASLVRI L------CEQIASD------TCHLQRVVFKNI-------------SP-----A--DAHRN LCLALR------------------GHKTVTYLTLQGN-DQDD--MFPALCEVLRHPECNL RYLGL-VSCSATTQQW--ADLSLALEVN-QSL-TCVNLS-DNELLDEGAKLLYTTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCHLTEAN----CKDLAAVLVVSRE-LTHL----------------- --------------------------------------------CLAKNPIGNTGVKFLC EGLRYPECKLQTL----------------------------------------------- ---------VLWNCDITSDGCCDLAKLLQEK-SSL------------------------- ------------------------------------------------------------ ---------------------------------------SCLDLGLNH-IGVKGMKFLCE A----------------------------------------------------------- --------------------------LRKPLCN--------------------------- -----------------------------------------------------------L RCL--WLWGCSIPPFSCE-------------------------------------DLCSA LSC---NQS---------------------------------LVTLDLGQNP-LGSSGVK MLFETLT-----CSSGT---LRTLR----L-KIDDFNDELNKLLEEIEEKNPQLI---ID TEKHHPWEERPSSHDFMI------------------------------------ >M_musculus_ENSMUSP00000081819 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MKTEDDE MEYEASKEETVSE----------------------------------------------- ------------------------------------------------------------ ----DKDFDD-------------------------------------------------- ----GIDYRTVIKENIFTMWYKTSLHGEFATLNCVITP---KDQN--------------- -------------LLQHIFDEDIQTSEAPQT--VVLQGAAGIGKTTLLK-KAVLEWADGN LYQQ-FTHVFYLNGKEISQ-VKEKS--FAQLISKH--WPSSEGPIEQVLSK-PSSLLFII DSFDELDFS------FE--EPQF----ALCKDWTQISPVSFLISSLLRKVMLPESYLLVA TRSTAWKRLVPLLQKPQRVKLSGLSKNARMDYIHHLLKDKA---------WATSAIYSLR MNWRLFHMCHVCHMCQMICAVLK-----GQVEKG-GRVEE--TCKTSTALFTYYICSLFP RIPVG----------CVTLPNETLLRSLCKAAVEGIW-TMKHVLYQQNLRKHELTRED-I LLF--LDAKVLQQDTE--YENCYMFTHL-HVQEFFAALFYLLRENLEEQ--D-------- --------------------------YPSEPF--ENLYLLLESNHIH-DPHLEQMKCFLF GLLNKDRVRQLEETFNLTISM--EVRE-ELLACLEGLEK--------------------- -----DDS---SLS-Q-LRFQDLLHCIYET-QDQEFITQALMYFQKI------------- -----IV-RVD-EEPQLRIYS-----FC-LKHCHTLKTMRLTAR-ADLKNMLDTAE---- -----------MCL-EGAAVQV-IHYWQDLFSVLH-TNES--LIEMDLYESRLDESLMKI L------NEELSHP------KCKLQKLIFRAV-------------DF-----L--NGCQD FT-FLA------------------SNKKVTHLDLKET-DLGV-NGLKTLCEALKCKGCKL RVLRL-ASCDLNVARC--QKLSNALQTN-RSL-VFLNLS-LNNLSNDGVKSLCEVLE--N -PNSSLERLALASCGL---TKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLK HPQC-TLQSLVLRSCSFTPIG----SEHLSTALLHNRS-LVHL----------------- --------------------------------------------DLGQNKLADNGVKLLC HSLQQPHCNLQEL----------------------------------------------- ---------ELMSCVLTSKACGDLASVLVNN-SNL------------------------- ------------------------------------------------------------ ---------------------------------------WSLDLGHNI-LDDAGLNILCD A----------------------------------------------------------- --------------------------LRNPNCH--------------------------- -----------------------------------------------------------V QRL--GLENCGLTPGCCQ-------------------------------------DLLGI LSN---NKS---------------------------------VIQMNLMKNA-LDHESIK NLCKVLR-----SPTCK---MEFLA----LDKKEILKKKIKKFLVDVRINNPHLV----- IGPECPNTESGCWWNYF------------------------------------- >H_sapiens_ENSP00000343891 ------------------------------------------------------------ ----------------MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDF WSAPQGHFP-RIPWANLRAADPLNL-SFLLDEHFPK-GQAWKVVLGIF-----QTMNLTS LCEKVRAE-----------------------------MKENVQTQELQDPTQEDLEMLEA AAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEM----------------- ----LEEADH-------------------------------------------------- ----RRKYRENMKAELLETWDNISWPKDHVYI-RNTSK---DEHE--------------- -------------ELQRLLDPN-RTRAQAQT--IVLVGRAGVGKTTLAM-QAMLHWANGV LFQQRFSYVFYLSCHKIRY-MKETT--FAELISLD--WPDFDAPIEEFMSQ-PEKLLFII DGFEEIIIS------ES--RSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLIT IKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSS---------EVEKILQQLR KNETLFHSCSAPMVCWTVCSCLK-----QPKVRY-YDLQS--ITQTTTSLYAYFFSNLFS TAEVD----------LADDSWPGQWRALCSLAIEGLW-SMNFTFNKEDTEIEGLEVPF-I DSL--YEFNILQKIND--CGGCTTFTHL-SFQEFFAAMSFVLEEPREFP--P-------- ------------------------HSTKPQEM--KML--LQHVLLDK-EAYWTPVVLFFF GLLNKNIARELEDTLHCKISP--RVME-ELLKWGEELGK--------------------- -----AES---ASL-Q-FHILRLFHCLHES-QEEDFTKKMLGRIFEV------------- -----DL-NIL-EDEELQASS-----FC-LKHCKRLNKLRLSVS-SHILERDLE------ -----------ILE-TSKFDSR-MHAWNSICSTLV-TNEN--LHELDLSNSKLHASSVKG L------CLALKNP------RCKVQKLTCKSV-------------TP-----E--WVLQD LIIALQ------------------GNSKLTHLNFSSN-KLGM--TVPLILKALRHSACNL KYLCL-EKCNLSAASC--QDLALFLTSI-QHV-TRLCLG-FNRLQDDGIKLLCAALT--H -PKCALERLE-------------------------------------------------- -----------LWFCQLAAPA----CKHLSDALLQNRS-LTHL----------------- --------------------------------------------NLSKNSLRDEGVKFLC EALGRPDGNLQSL----------------------------------------------- ---------NLSGCSFTREGCGELANALSHN-HNV------------------------- ------------------------------------------------------------ ---------------------------------------KILDLGEND-LQDDGVKLLCE A----------------------------------------------------------- --------------------------LKP-HRA--------------------------- -----------------------------------------------------------L HTL--GLAKCNLTTACCQ-------------------------------------HLFSV LSS---SKS---------------------------------LVNLNLLGNE-LDTDGVK MLCKALK-----KSTCR---LQKLG----------------------------------- ------------------------------------------------------ >P_pygmaeus_ENSPPYP00000011655 ------------------------------------------------------------ ----------------------MVSSAQMGFNLQALLEQLSQDELSKFKFLITTASLA-- ----H-ELQ-KIPHKEVDKADGKQL-AEILTSHCDS-YWVEMASIQVF-----EKMHRMD LSQRAKDELREAALKSLNKRKPLSLGITRK-EQPPLDVEEMLEHFKAEALAFTETKEGNV TCLGKEVF--K------------------------------------------------- ----GEKPDK-------------------------------------------------- ----DNRYRYILKTKFREMWKS--WPGDSKEVQ-VMAE----RYK--------------- -------------MLIPFSNPRVLPGPFSYT--VVLYGPAGLGKTTLAQ-KLMLDWAEDN LIH-KFKYAFYLSCRELGR-LGPCS--FAELISKD--WPELQDDIPHILAQ-AQKILFVI DGFDELGAA------PG--ALIQ----DMCRDWEKKKPVPVLLGSLLNRYMLPKAALLVT TRPRALRDLRFLVEEPIYIRVEGFLEEDRRAYFLRHFGDED---------QATRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDTAP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALWMLSFLAAQGLW-AQMSVLHREDLERLRVQESD-L RLF--LDGDILRQDTV--SKGCYSFIHL-SFQQFLTALFYALEKEEEED--R-------- ---------DG-------------HAWDIGDI--QKL--LSGEERLR-NPDLIQAGYYSF GLANEKRAKELEATFGCRISP--DIKQ-ELLQCDISCKG--------------------- -----GHS-----T-V-TDLKELLGCLYES-QEEELVKEVMAQFKEI------------- -----SL-HL--NAVDVVPSS-----FC-LKHCQNLQKMSLQVI-QANLPENVTASESDA E----------VER-SQDDQHV-LPFWMDLCSIFG-SNKD--LMGLAINNSFLSASLVRI L------CEGIASD------TCHLQRVVFKNI-------------SP-----A--VFNRN LCLALR------------------GHKTVTYLT-QGN-DQND--MLPALCEVLRHPECNL RYLGL-VSCSTTTQQW--ADLSLALEVN-QSL-TCVNLS-DNELLDEGAKLLYTTLR--H -PKCLLQRLS-------------------------------------------------- -----------LENCHLTEAN----CKDLAAVLVVSRE-LTHL----------------- --------------------------------------------CLAKNPIGDTGVELLC EGLRYPECKLQTL----------------------------------------------- ---------VLWNCNITSNGCCNLAKLLQEK-SSL------------------------- ------------------------------------------------------------ ---------------------------------------SCLDLGLNY-IGVSGMKLLCE A----------------------------------------------------------- --------------------------LRKPLCN--------------------------- -----------------------------------------------------------L RCL--WLWGCSIPLFSCE-------------------------------------DLCSA LSC---NQS---------------------------------LVTLDLGQNP-LGSSGVK MLFETLT-----HPNGT---LRTLR----L-KIDDFNDELNKLLEEIEEKNPQLI---ID TEKHDPWKKRPSSHDFVI------------------------------------ >O_anatinus_ENSOANP00000018896 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RELNL-ERKRS--AVQLIQQC--CDDDGVPLSEICRR-SDRLLFLV DGFDELGWSSGGWPGAA--DDDD----DLFVDWKDKRPVGSLLAHLIRKRLFPKASLLIT TRPAAAESLRPLLRWPRRAEILGFSEAERAEYFHHYFLDSG---------RANRALAFIQ ENDVLFTMCFVPLICWIVCTGLR-----QQMDRR-EDLAQ--ASKTTTAVYLSFLSSLLR PARHL-----------PSRVPPAHLRGLCSLAADGIL-SQRILFRKADLRKHGLPEDG-L SAF--LHVDVFEKDVD--CETLFSFVHL-TFQEFFAALFYLLGPDETGP----------- --------------------------GPLPDA--RTL--LQHYRLCD-TGFLTLTVRFFF GLLNRERVADLKATMDCVVRP--EARR-ALVEWIDTSAR--------------------- -----KEA-------LPGPTLQWLYCFYEI-QEVDFVERAMGSFRKI------------- -----DI-DVR-TRMDQIVVA-----FC-LRNSRNLCSIELMRF-FNVAEADAAAAAAER TPEVA------ADR-RPQDWLQ-DTLCESLSEASA-NNRG--LTHLALRNKNLGRRGAEL L------SKGLSHP------NCKLKSLRLPNC-------------TRRPQDWLQDTLCES LSEASA------------------NNRGLTHLALRNK-NLGR-RGAELLSKGLSHPNCKL KSLRL-VNCLLTPDSC--RDFSSILSTD-RNL-SELDLS-SNALKDSGLSLLCEGLR--H -PSCKLQTLW-------------------------------------------------- -----------LQSCALTSAC----GPALSSLLTTSAN-LTKL----------------- --------------------------------------------DLFNNALGDTGVSLIC EGLKHPNCKLQAL----------------------------------------------- ---------LLRHCALTLNCCPDLSSVLSIN-RDL------------------------- ------------------------------------------------------------ ---------------------------------------SELDLSYNS-LEDAGVCLLCE G----------------------------------------------------------- --------------------------LRHPNCK--------------------------- -----------------------------------------------------------L QTL--RLQKCKLTSRSCS-------------------------------------DLSQA LGI---NRE---------------------------------LRELILHDNV-LGDAGIS VIWKGIQ-----QPSCG---LKILR----L-GKTHFSEKMEEEMRTVQKMKPELKIRY-- ------------------------------------------------------ >E_caballus_ENSECAP00000021583 ------------------------------------------------------------ -------------------MEEAEVPSLSNYGLQWCFKQLSKEEFQTFKELLNEKASE-- ----L-EAG-SFPWVEVNNANIEHL-ASLLHEHYRG-SLAWKISINIF-----EKMNLSA LSEKARDE-----------------------------MKKYSLAEIPKASTP-KTDQEPS MEEVPGP----------------------------------------------------- ----RSDEDD-------------------------------------------------- ----KWYYKSYVMTKFAMKLDACYGFKNFTSEH--------PEMQ--------------- -------------TLLGAFKPDQN-GFQPHT--VVLHGEPGIGKSTLAR-RILLSWAQGE VYQDLFSYAFFLCAREIQQ-IREST--LAELISRE--WPDSPVPVMEIMSQ-PERLLFVV DGFDDLDFV------FK--DGDI----NLCEDWAEKQPMSILMYSLLKKVLLPESSLIIT VRDAGIEKLKSIVMSPRYLLLEGISVEKRIQLLLQHIKNDH---------QKMQVLQSVV DNHLLFDKCQVSVVCSLICEALK-----LQEMSG-KSPPP--TCQTLTGLYATFVFHQLT PQDAFP--------RALSQEERVVLKGVCRLAVEGMW-NMKSVFYGDDLGVHGLRKSE-L SAL--FHMNILLQDSH--CERCYSFLHL-SLQEFCAALYYVLVGLEREG--D-------- --------------------------LYPLFI--ENIGSLTELKQFGISVHLLQMKRFLF GLMSKEVIKTLEALLGCPVPV--VVKQ-KLLHWISLLGQ--------------------- -----QAN---STA-P-LDFLDAFYCLFET-QDEEFIRLALNSFQEV------------- -----RL-PMN-RRMDLIVSS-----FC-LPHCRYLRKIRMDVR-EILSRDELTEAWP-M I----------PEG-MQTKTFI-DKSWENFCFVLS-THPN--LQELDLSGSVLDEWAIKT F------CVKLRQP------TCKIQNLIFKGA-------------QI-----T--LGLRH LWMTLL------------------VNRNIKYLNLERT-RLKN-EDVGMACEALRHPNCLL ESLRL-DHCGLTHACC--VVISQILMTS-INL-KSLSLA-GNKVTDQGMKPLCDALK--V -SQCTLQRLILGNCGL---TAADCQDLASSLISNLSLTHLDLSSNSLGSEGMNLLYRTIK LPNC-GLQRLILNECNLDIAS----CGFLGFALVGNRR-LTHL----------------- --------------------------------------------SLSMNPLEDAGVNLLC EVMMEPSCHLQDL----------------------------------------------- ---------ELVKCNLTAACCKNLSLMISTS-KRL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLAANA-LRDEGIVALCQ G----------------------------------------------------------- --------------------------LKQRKSS--------------------------- -----------------------------------------------------------L RRL--GLEACELTSGCCE-------------------------------------VLSSA LSC---NQH---------------------------------LTSLNLIRNN-FSPGGMM KLCSAFA-----HPTSN---LQIIG----L-WKLQFPAQVRKMLEEVQLLKPHII---ID DGWYS------------------------------------------------- >E_caballus_ENSECAP00000021325 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------MTGAQPQT--IVLEGRAGVGKTTLAM-KVMLHWAEGF LFQHRFSYVFYISCHKMKE-MEDTT--FADLLSQD--WPDSQAPIEEFICH-PERLLFVI DGFEEMAMP------SK--LSDS----PPCTDWYQQLPVARILLHLLKKELIPTATLLIT TRDYRNGALKKLLLNPWFVLISGFTEGDRSEYFFRYFGDRN---------IAKKILHWIR KNETLFHSCSAPLVCWTVCSSLK-----RQMARN-PHFQL--STQTTTSLYAHFFSSLFA TAEVS----------LSDQSWPEQWRALCSLAAEGMW-FSNFTFAKEAIEHRRLEASL-I DSL--LSLNILRKASD--CEDCIAFTHQ-SFQVFFGAMFYVLRGTEGSI--G-------- ------------------------GPTRHQEM--RVL--LNDALADT-NFYWNQMALFFF GLLKRDLARELEDTLHCKMSS--RIMD-ELLKWSEELDK--------------------- -----FDT---VSN-H-FEFLQFFHCLYET-QEENFVRQILNHLLEA------------- -----DL-NIF-GNLQLQVSS-----FC-LKHCQRLSKLRLSVS-RPLIPKIIPFIVR-- ------------ID-TQLVDSK-IRQWQDICSVF--CNGN--VSELDLSNSELNTSSMKK L------CYKLRNP------WCKLQKLTCKSI-------------TP-----V--RILKE LVLVLY------------------GNNKLTHLNLSSN-NLGV-TVSTMIFRTLRHSACNL KYLWL-ESCGLSSRVC--HQLFLELSKN-SSL-SFLSLG-DNDLSDIEVKSLQEPFE--M -SKCSLKELSLEKCNL---SASSYQNLALLLPSTQRLTRLCLGFNQLQDDGVKLLCSSLS HPEC-ALERLVLWFCQLGTPS----CRYLSEALLRNKS-LTHL----------------- --------------------------------------------NLRKNNLGDEGVKVLC KALSHLDCNLQNL----------------------------------------------- ---------DLSDCSFTTESCGELANVLKHN-HNV------------------------- ------------------------------------------------------------ ---------------------------------------KILDIGNND-VQDDGVKRLCK V----------------------------------------------------------- --------------------------LKHSNCA--------------------------- -----------------------------------------------------------L NTL--G------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >P_troglodytes_ENSPTRP00000019828 ------------------------------------------------------------ ----------------MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDF WSAPQGHFP-RIPWANLRAADPLNL-SFLLDEHFPK-GQAWKVVLGIF-----QTMNLTS LCEKVRAE-----------------------------MKENVQTQELQDPTQEDLEMLEA AAGNMQTQGCQDPNQEELEELEEETGNVQAQGCQDPNQEEPEM----------------- ----LEEADH-------------------------------------------------- ----RRKYRENMKAELLETWDNISWPKDHVYI-RNTSK---DEHE--------------- -------------ELQRLLDPN-RTRAQAQT--IVLVGRAGVGKTTLAM-QAMLHWANGV LFQQRFSYVFYLSCHKIRY-MKETT--FAELISLD--WPDFDAPIEEFMSQ-PEKLLFII DGFEEIIIS------ES--RSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLIT IKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSS---------EVEKILQQLR KNETLFHSCSAPMVCWTVCSCLK-----QPKVRY-YDLQS--ITQTTTSLYAYFFSNLFS TAEVD----------LADDSWPGQWRALCSLAIEGLW-SMNFTFNKEDTEIEGLEVPF-I DCL--YEFNILQKIND--CGGCTTFTHL-SFQEFFAAMSFVLEEPREFP--P-------- ------------------------HSTKPQEM--KML--LQHVLLDK-EAYWTPVVLFFF GLLNKNIARELEDTLHCKISP--RVME-ELLKWGEELGK--------------------- -----AES---ASL-Q-FHVLRLFHCLHES-QEEDFTKKMLGRIFEV------------- -----DL-NIL-EDEELQASS-----FC-LKHCERLNKLRLSVS-SHILERDLE------ -----------ILE-TSKFDSR-MHAWNSICSTLV-TNEN--LHELDLSNSKLHASSVKG L------CLALKNP------RCKVQKLTYKSV-------------TP-----E--WVLQD LIIALQ------------------GNSKLTHLNLSSN-KLGM--TVPLILKALRHSACNL KYLCL-EKCNLSAASC--QDLALFLTSI-QHV-TRLCLG-FNRLQDDGIKLLCAALT--H -PKCALERLE-------------------------------------------------- -----------LWFSQLAAPA----CKHLSDALLQNRS-LTHL----------------- --------------------------------------------NLSKNSLRDEGVKFLC EALGRPDGNLQSL----------------------------------------------- ---------NLSGCSFTREGCRELANALSHN-HNV------------------------- ------------------------------------------------------------ ---------------------------------------KILDLGEND-LQDDGVKLLCE A----------------------------------------------------------- --------------------------LKP-HRA--------------------------- -----------------------------------------------------------L HTL--GLAKCNLTTACCQ-------------------------------------HLFSV LSS---SKS---------------------------------LVNLNLLGNE-LDTDGVK MLCKALK-----KSTCR---LQKLG----------------------------------- ------------------------------------------------------ >P_troglodytes_ENSPTRP00000019832 -------------MKVAGGLELGAVALL--ASHDLVTLSTGPTCSILPKNP--------- ------LFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSE-- ----S-TTC-SIPQFEIENANVECL-ALLLHEYYGA-SLAWATSISIF-----ENMNLRT LSEKARDD-----------------------------MKRHS----SEDPEATTTDQGPS KEKVPGISQAVQQDSATA-------------------AETKEQEISQAMEQEGATAAETE E---QGHGGD-------------------------------------------------- ----TWDYKSHVMTKFAEEQDVRRSFEKSAADW--------PEMQ--------------- -------------TLAGAFNSDQW-GFRPRT--VVLHGKSGIGKSALAR-RIVLCWAQGG LYQGMFSYVFFLPVREMQR-KKESS--VTEFISRE--WPDSQAPVTEIMSR-PERLLFII DGFDDLGSV------L---NSDT----KLCKDWAEKQPPSILIRSLLRKVLLPESFLIIT VRDVGIEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEH---------QKTQGLRAIM NNRKLFDQCQVPAVGSLICVALQ-----LQDVVG-ESVAP--FNQTLTGLYAAFVFHQLT PRGVAR--------RCLNLEERVVLKRFCRMAVEGVW-NRKSVFDGDDLMVQGLGESE-L RAL--FHMNILLPDSH--CEEHYTFFHL-SLQDFCAALYYVLEGLEIEP--A-------- --------------------------LCPLYV--EKTKRSMELKQAGFHIHSLWMKRFLF GLVSEDVRRPLEVLLGCPVPL--GVKQ-KLLHWVSLLGQ--------------------- -----QQK---A---P-GDTLDAFHCLFET-QDKEFVRLALNGFQEV------------- -----WL-PIN-QNLDLIASS-----FC-LQHCPYLRKIRVDVK-GIFPRDESAEACP-V V----------PLW-MRGKTLI-EEQWEDFCSVLG-THPH--LRQLDLGSSILTERAMKT L------CAKLRHS------TCKIQTLMFRNA-------------QI-----T--AGVQH LWRILM------------------ANRNLRSLNLGGT-HLKE-EDVRMACEALKHPKCLL ESLRL-DCCGLTHACY--LKISQILTTS-PSL-KSLSLA-GNKVTDQGVTPLSDALR--V -SQCALQKLILEDCGI---TATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMR LPHC-SLQRLMLNQCHLDTAG----CGFLALALMGNSW-LTHL----------------- --------------------------------------------SLSMNPVEDNGVKLLC EVMREPSCHLQDL----------------------------------------------- ---------ELVKCHLTAACCESLSCVISRS-RHL------------------------- ------------------------------------------------------------ ---------------------------------------KSMDLTDNA-LGDVGVAALCE G----------------------------------------------------------- --------------------------LKQKNSV--------------------------- -----------------------------------------------------------L TRL--GLKACGLTSDCCE-------------------------------------ALSLA LSC---NRH---------------------------------LTCLNLVQNN-FSPKGMM KLCSAFA-----CPTSN---LQIIG----L-WKWQYPVQIRKLLEEVQLLKPQIV---ID GSWHSFDEDDRYWWKN-------------------------------------- >G_gorilla_ENSGGOP00000001243 ------------------------------------------------------------ ----------------------MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLA-- ----H-ELQ-KIPHKEVDKADGKQL-VEILTSHCDS-YWVEMASLQVF-----EKMHRMD LSERAKDEVREAALKSFNKRKPLSLGITRK-ERPPLDVDEMLERFKTEALAFTETK-GNV ICLGKEVF--K------------------------------------------------- ----GKKPDK-------------------------------------------------- ----DNRCRYMLKTKFREMWKS--WPGDSKEVQ-VMAE----RYK--------------- -------------MLIPFSNPRVLPGPFSYT--VVLYGPAGLGKTTLAQ-KLMLDWAEDN LIH-KFKYAFYLSCRELSR-LGPCS--FAELVFRD--WPELQDDISHILAQ-ARKILFVI XGFDELGAA------PG--ALIE----DICGDWEQKKPVPVLLGSLLNRVMLPKAALLVT TRPRALRDLRILAEEPIYLRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDLVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQTSVLHREDLERLGVQESD-L CLF--LDGDILRQDTV--SKGCYSFIHL-SFQQFLTAVFYALEKEEEED--R-------- ---------DG-------------HTSDIGDV--QKL--LSGAERLR-NPDLIQAGYYSF GXANEKRAKELEATFGCRMSP--DIKQ-ELLRCDISCKG--------------------- -----GXS-----T-G-TDLQELLGCLYES-QEEELVKEVMAQFKEI------------- -----SL-HL--NAVDVVASS-----FC-VKHCRNLQKMSLQVI-KENLPENVTASESDA E----------VEX-XXXXXXX-XXXXXXXXXXXX-XXXX--XXXXXXXXXXXXXXXXXX X------XXXXXXX------XXXXXXXXFKNI-------------SP-----A--DAHRN LCLALR------------------GHKTVTYLTLQGN-DQDD--MFPALCEVLRHPECNL RYLGL-VSCSATTQQW--ADLSLALEVN-QSL-TCVNLS-DNELLDEGAKLLYTTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCHLTEAN----CKDLAAVLVVSRE-LTHL----------------- --------------------------------------------CLAKNPIGNTGVKFLC EGLRYPECKLQTL----------------------------------------------- ---------VLWNCDITSDGCCDLAKLLQEK-SSL------------------------- ------------------------------------------------------------ ---------------------------------------SCLDLGXXX-XXXXXXXXXXX X----------------------------------------------------------- --------------------------XXXXXXX--------------------------- -----------------------------------------------------------X XXX--XLWGCSIPPFSCE-------------------------------------DLCSA LSC---NQS---------------------------------LVTLDLGQNP-LGSSGVK MLFESLT-----CSNGT---LRTLR----L-KIDDFNDELXKLLEEIEEKNPQLI---ID TEKHHPWEERPSSHDFMI------------------------------------ >H_sapiens_ENSP00000329568 ------------------------------------------------------------ ----------------------M-TSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLE-- ----D-VLQ-KTPWSEVEEADGKKL-AEILVNTSSE-NWIRNATVNIL-----EEMNLTE LCKMAKAEMMEDG--QVQEIDNPELG----------DAEEDSELAKP------------- ------------------------------------------------------------ ----GEKEGW-------------------------------------------------- ----RNSM-----EKQSLVWKNTFWQGDIDNFHDDVTL----RNQ--------------- -------------RFIPFLNPRTPRKLTPYT--VVLHGPAGVGKTTLAK-KCMLDWTDCN LSP-TLRYAFYLSCKELSR-MGPCS--FAELISKD--WPELQDDIPSILAQ-AQRILFVV DGLDELKVP------PG--ALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQMSVFHREDLERLGVQESD-L RLF--LDGDILRQDRV--SKGCYSFIHL-SFQQFLTALFYALEKEEGED--R-------- ---------DG-------------HAWDIGDV--QKL--LSGEERLK-NPDLIQVGHFLF GLANEKRAKELEATFGCRMSP--DIKQ-ELLQCKAHLHA--------------------- -----NKP---L-S-V-TDLKEVLGCLYES-QEEELAKVVVAPFKEI------------- -----SI-HLT-NTSEVMHCS-----FS-LKHCQDLQKLSLQVA-KGVFLENYMDFELDI EFE-------------------------------S-SNSN--LKFLEVKQSFLSDSSVRI L------CDHVTRS------TCHLQKVEIKNV-------------TP-----D--TAYRD FCLAFI------------------GKKTLTHLTLAGH-IEWERTMMLMLCDLLRNHKCNL QYLRL-GGHCATPEQW--AEFFYVLKAN-QSL-KHLRLS-ANVLLDEGAMLLYKTMT--R -PKHFLQMLS-------------------------------------------------- -----------LENCRLTEAS----CKDLAAVLVVSKK-LTHL----------------- --------------------------------------------CLAKNPIGDTGVKFLC EGLSYPDCKLQTL----------------------------------------------- ---------VLQQCSITKLGCRYLSEALQEA-CSL------------------------- ------------------------------------------------------------ ---------------------------------------TNLDLSINQ-IA-RGLWILCQ A----------------------------------------------------------- --------------------------LENPNCN--------------------------- -----------------------------------------------------------L KHL--RLWSCSLMPFYCQ-------------------------------------HLGSA LLS---NQK---------------------------------LETLDLGQNH-LWKSGII KLFGVLR-----QRTGS---LKILR----L-KTYETNLEIKKLLEEVKEKNPKLT---ID CNASGAT--APPCCDFFC------------------------------------ >C_familiaris_ENSCAFP00000003671 ------------------------------------------------------------ --------------SKMSSSANIYVDNGSYDKLLSYLMGLDQSQLEEFKLCLQSPQLL-- ----LENFR-KIPWANLKAIDPINL-LCLLSEYFSE-KQMWEVTLSIF-----ENMNLTS LCMEIGAT-----------------------------MNEMEQALGPQDPNQEAAEMPEE E----------------------------------------------------------- ----KAPLFH-------------------------------------------------- ----RRRYRERMKAKILMMWDNMPWPEDHIYL-RNVTE---KEHD--------------- -------------ELKSLLYPN-RTGAQPQT--IILEGIAGVGKTTLAM-KAMLHWAEGF LFQQRFSYVFFISCHKVKD-MKDTT--FAGLLSWD--WPDSQVPIEELMSH-PERLLFVI DGFEEMDMP------SN--LDNS----PPCTDWYQQLPVNRILFYLLKKELVPMATLLIT TKEYRTKDLKKLLLNPWFVQILGFTEGDREEYFIRYFGDQK---------KAKKVLYWVR KNETLFYFCSAPLVCWTVCSCLK-----RQMVRN-PHFQI--STQTTTSLYVHFFSSLFA TAEVS----------LSEQNWPGQWSALCSLAAEGMW-FRNFTFTKEDLKHKCLEAHL-I GSL--LRLNILRKVND--CEECVTFTHQ-SFQVFLGAMFYVLWGTKGSI--G-------- ------------------------GPAKHEEM--RVL--LNNALVDR-NFYWNQMALFFF GLLKRSLIRELEDTLCCKVGQ--RIMD-ELLEWAEELKS--------------------- -----YDI---VLN-R-FEFLHFFSCLYET-QEENFVRQILSHLLEA------------- -----DI-NIF-GNQQLQVSS-----FC-LKHCRSLSKLRLSVT-SSILQTELTFSVE-- -----------TLD-MSWGGDR-SNCWQDICSVF--CNGH--VSELDLSNSKLNTSSMKK L------CYELRNP------RCKLRKLTCKSI-------------TP-----V--KILKE LVLVLH------------------GNNRLTHLNLSSN-NLGV-PVSTMIFKTLRHSACNL QYLWL-ESCGLTPLVC--RHLFVELSRN-SSV-SFLSLG-DNDLS--GMKGLQGPSG--M -STSSLKELSLEKCNL---SAAIYQDLALHVSSTQRTTRLCLGFNPLQDDGVRLLCAALT HPEC-ALERLVLWFCQLGAPS----CRYLSEALLKNKS-LTHL----------------- --------------------------------------------NLRRNKLRDEGVKFLC KALSHPDCSLQNL----------------------------------------------- ---------DLSDCSFTADGCQELANALRHN-HNM------------------------- ------------------------------------------------------------ ---------------------------------------KILDIRNND-VQDNGVKHLCE V----------------------------------------------------------- --------------------------LQDPYCE--------------------------- -----------------------------------------------------------L NTL--GLEKCNLTPACCQ-------------------------------------HLSSV LTS---SKS---------------------------------LINLNLLEND-LEPSGVS ILWKALK-----KSMCK---LQKLG------LKKELYDLVKVELEELQERGSFLR---VK YKWDFNDLEDKWWW---------------------------------------- >O_cuniculus_ENSOCUP00000004733 ------------------------------------------------------------ ------------------------GMAGTRCKLAQYLEDLEELDLKKFKMHLEDYPPD-- ----Q-GCI-PLPRGQAARADPVDL-ATLMIDFNGE-EKAWAMALWIF-----TAINRRD LYERAKRDEP-------------VWGSEPAHVSNATVICHEEIIEEERMGILGHLSRISI C----------------------------------------------------------- ----TKRKDY-------------------------------------------------- ----CKKYRKHVRSRFQCIEDRNARLGESVNLNKRYTRLRLAKEHLSRQEREQELVAIGR T--HVWDSPASPVRVELLFDADEECLEPVRT--VVLQGAAGIGKTILAR-KIMLDWASGQ LFQDRFDYLFYIHCREMSL-GMHRS--LVDLIAGC--CSDPSPPVSKMLHR-PSRVLFLM DGFDELQGA------FD--ESSG----ALCSDWRVAVRGDVLLGSLIRKKLLPEASLLIT TRPVALEKLQHLLDRPRHVEVLGFSEARRKEYFFKYFLEEA---------HAREAFSLLQ ENEVLLSMCCIPLVCWIVCTGLK-----QQMQGG-KHRAKTTTSKTTTAVYTFFLSSLLQ SRGGS-----------QEQRLSGHLRGLCSLAADGIW-NQKILFEERDLRRHGLQEAE-V SAF--LRMSLFQKEVD--CEAFYSFVHL-TFQEFFAAMYYVLEEEEEER--R-------- -----SPPARG-------------LDLPHRDV--RVL--LENYGKFE-KGYLIFVVRFLF GLXXXXXXXXXXXXXXXXXXX--XXXX-XXXXXXXXXXX--------------------- -----XXX---XXX-X-XXXXXXXXXXXXX-XXXXXXXXXXXXXXXX------------- -----XXXXXX-XXXXXXXXX-----XX-XXXXXXXXXXXXXXX-XXXXXXXXXXXXX-- ------------------------------------------XXXXXXXXXXXXX-XXXX X------XXXLV--------NSCLTS-----------------------------SFCRG LFSVLS------------------TNPSLTELDLSDN-SLGD-PGMRVLCEALQHPGCNI RRLWL-GRCGLSHQCC--FDISLVLSGS-QKL-VELDLS-DNALGDFGVRLLCVGLR--H ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LSCQLQKL----------------------------------------------- ---------XXXXXXXXXXXXXXXXXXXXXX-XXX------------------------- ------------------------------------------------------------ ---------------------------------------XXXXXXXXX-XXXXXXXXXXX X----------------------------------------------------------- --------------------------XXXXXXX--------------------------- -----------------------------------------------------------X XXX--XLDSCSLTSHCCW-------------------------------------NLCTI LTC---SRS---------------------------------LRKLSLGNND-LGDLGVM MLCEVLR-----QPDCP---LQRL------------------------------------ ------------------------------------------------------ >G_gorilla_ENSGGOP00000008087 ------------------------------------------------------------ ----------------MNFSVITCPNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDF WSXPQGHFP-RIPWANLRAADPLNL-SFLLDEHFPK-GQAWKVVLGIF-----QTMNLTS LCEKVRAE-----------------------------MKXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXNVQAQGCQDPNQEEPEM----------------- ----LEEAXX-------------------------------------------------- ----XXXXXXXXXXXXXXXXXXXXXXXXXXYI-RNTSK---DEHE--------------- -------------ELQRLLDPN-RTRAQAQT--IVLVGRAGVGKTTLAM-QAMLHWANGV LFQQRFSYVFYLSCHKIRY-MKETT--FAELISLD--WPDFDAPIEEFMSQ-PEKLLFII DGFEEIIIS------ES--RSESLDDGSPCTDWYQELPVTKILYSLLKKELVPXATLLIT IKTWFVRDLKASLXNPCFVQITGFTGDDLRVYFMRHFDDSS---------EVEKILQQLR KNETLFHSCSAPMVCWTVCSCLK-----QPKVRY-YDLQS--ITQTTTSLYACFFSNLFS TAEVD----------LADDSWPGQWRALCSLAIEGLW-SMNFTFNKEDTEIEGLEVPF-I DCL--YEFNILQKIND--CGGCTTFTHL-SFQEFFAAMSFVLEEPREFP--P-------- ------------------------HSTKPQEM--KML--LQHVLLDK-EAYWTPVVXFFF GLLNKNTARELEDTLHCKISP--RVME-ELLKWGEELGK--------------------- -----AES---ASL-Q-FHVLRLFHCLHES-QEEDFTKKMLGRIFEV------------- -----DL-NIL-EDEELQASS-----FC-LKHCKRLNKLRLSVS-SHILERDLE------ -----------ILE-TSKFDSR-MHAWNSICSTLV-TNEN--LHELDLSNSKLHASSVKG L------CLALKNP------RCKVQKLTXXXX-------------XX-----X--XXXXX XXXXXX------------------XXXXXXXXXXXXX-XXXX--XXXXXXXXXXXXXXXX XXXXL-EKCNLSAASC--QDLALFLTSI-QHV-TRLCLG-FNRLQDDGIKLLCAALS--H -PKCALERLE-------------------------------------------------- -----------LWFCQLAAPA----CKHLSDALLQNRS-LTHL----------------- --------------------------------------------NLSKNSLRDEGVKFLS EALGRPDGNLQSL----------------------------------------------- ---------XXXXXXXXXXXXXXXXXXXXXX-XXX------------------------- ------------------------------------------------------------ ---------------------------------------XXXXXXXXX-XXXXXXXXXXX X----------------------------------------------------------- --------------------------XXX-XXX--------------------------- -----------------------------------------------------------X XXX--XLAKCNLTTACCQ-------------------------------------HLFSV LSS---SKS---------------------------------LVNLNLLGNE-LDPDGVK MLCKALK-----KSTCR---LQKLG----------------------------------- ------------------------------------------------------ >M_musculus_ENSMUSP00000104293 ------------------------------------------------------------ --------------------MLPSTARDGLYRLSTYLEELEAGELKKFKLFLGIAEDL-- ------SQD-KIPWGRMEKAGPLEM-AQLMVAHMGT-REAWLLALSTF-----QRIHRKD LWERGQGEDL-------------VRVTPNN----------GLCLFES---QSACPLDVSP N----------------------------------------------------------- ----APRKDL-------------------------------------------------- ----QTTYKDYVRRKFQLMEDRNARLGECVNLSNRYTRLLLVKEHSNPIWTQQKFVDVEW ERSRTRRHQTSPIQMETLFEPDEERPEPPHT--VVLQGAAGMGKSMLAH-KVMLDWADGR LFQGRFDYVFYISCRELNRSHTQCS--VQDLISSC--WPERGISLEDLMQA-PDRLLFII DGFDKLHPS------FH--DAQG----PWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLIT TRPCALEKLHGLLEHPRHVEILGFSEEARKEYFYRYFHNTG---------QASRVLSFLM DYEPLFTMCFVPMVSWVVCTCLK-----QQLESG-ELLRQ--TPRTTTAVYMFYLLSLMQ PKPGT-----------PTFKVPANQRGLVSLAAEGLW-NQKILFDEQDLGKHGLDGAD-V STF--LNVNIFQKGIK--CEKFYSFIHL-SFQEFFAAMYCALNGREA------------- -------------------------------V--RRA--LAEYGFSE-RNFLALTVHFLF GLLNEEMRCYLERNLGWSISP--QVKE-EVLAWIQNKAG--------------------- -----SEG---STL-Q-HGSLELLSCLYEV-QEEDFIQQALSHFQVV------------- -----VVRSIS-TKMEHMVCS-----FC-ARYCRSTEVLHLHGS-AYSTGMEDDPPEPSG VQTQS------TYL-QERNMLP-DVYSAYLSAAVC-TNSN--LIELALYRNALGSQGVRL L------CQGLRHA------SCKLQNLR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >H_sapiens_ENSP00000331857 ------------------------------------------------------------ ----------------------MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEK-- ----F-ELK-PIPWAELKKASKEDV-AKLLDKHYPG-KQAWEVTLNLF-----LQINRKD LWTKAQEE-----------------------------MR--------------------- ------------------------------------------------------------ --------NK-------------------------------------------------- ----LNPYRKHMKETFQLIWEKETCLHVPEHFYKETMK---NEYK--------------- -------------ELNDAY----TAAARRHT--VVLEGPDGIGKTTLLR-KVMLDWAEGN LWKDRFTFVFFLNVCEMNG-IAETS--LLELLSRD--WPESSEKIEDIFSQ-PERILFIM DGFEQLKFN------L---QLKA----DLSDDWRQRQPMPIILSSLLQKKMLPESSLLIA LGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKS---------KALKVFNFVR DNGPLFILCHNPFTCWLVCTCVK-----QRLERG-EDLEI--NSQNTTYLYASFLTTVFK AGSQS----------FPPKVNRARLKSLCALAAEGIW-TYTFVFSHGDLRRNGLSESE-G VMW--VGMRLLQRRG-----DCFAFMHL-CIQEFCAAMFYLLKRPKDDP--N-------- --------------------------PAIGSI--TQL--VRASVVQP-QTLLTQVGIFMF GISTEEIVSMLETSFGFPLSK--DLKQ-EITQCLESLSQ--------------------- -----CEA---DRE-A-IAFQELFIGLFET-QEKEFVTKVMNFFEEV------------- -----FI-YIG-NIEHLVIAS-----FC-LKHCQHLTTLRMCVE-NIFPDDSGCISDYN- --------------------EK-LVYWRELCSMFI-TNKN--FQILDMENTSLDDPSLAI L------CKALAQP------VCKLRKLIFTSV-------------YF--------GHDSE LFKAVL------------------HNPHLKLLSLYGT-SLSQ-SDIRHLCETLKHPMCKI EELIL-GKCDISSEVC--EDIASVLACN-SKL-KHLSLV-ENPLRDEGMTLLCEALK--H -SHCALERLM-------------------------------------------------- -----------LMYCCLTSVS----CDSISEVLLCSKS-LSLL----------------- --------------------------------------------DLGSNALEDNGVASLC AALKHPGCSIREL----------------------------------------------- ---------WLMGCFLTSDSCKDIAAVLICN-GKL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGHNE-IGDTGVRQLCA A----------------------------------------------------------- --------------------------LQHPHCK--------------------------- -----------------------------------------------------------L ECL--GLQTCPITRACCD-------------------------------------DIAAA LIA---CKT---------------------------------LRSLNLDWIA-LDADAVV VLCEALS-----HPDCA---LQMLG----L-HKSGFDEETQKILMSVEEKIPHLT---IS HGPWIDEEYKIRGVLL-------------------------------------- >C_familiaris_ENSCAFP00000003649 ------------------------------------------------------------ --------------------------SPFENGVMLYMVYLSKEELQTFKQLLVDERPR-- ----P-GSV-QITWDQVKTARWGEV-VHLLMEYFPG-RLAWDVTHDIF-----AKMNQME LCLRVQME-----------------------------LNDILPSLELEDSNPREMPVSLE ------------------------------------------------------------ ----EGESDK-------------------------------------------------- ----IQEYKLYMIDEYSMIRSKTTWPGNHMDFFYQDIE---RHER--------------- -------------FLPCIFLPKRPQGRQPKT--VVLQGVSGVGKSSLAG-KVMLEWAKNK FYSHKFWYAFYFHCREVAQ-VDEQS--LSELIAHK--WPRAQALMSKIMSK-PDQLLLLF DGFEEVTLT------LT--DRPT----DLSEDWSQKLPGSVLLTSLLSKIMLPEATLLIT LRFTSWRKLKPFLKHPSFITLTGFSMVEKVKYFRTYFRNKR---------EADEALSFVM GNTILFSMCQVPVICWMVCSCLR-----QQMEKG-VDLVQ--AYPNATAVFVQYLSSLFP TKAGS----------LPSNTHQEQLRGLCYLAAEGMW-NMRWVFDMKDFEQAKLDETA-V ATF--LHVNIFRRVAG--DKDYYAFADL-SFQEFFAALLYVLCFPQRLR--N-------- --------------------------FWVLDR--VQIICLIAYPGRK-KNHLAQMGLFLF GLLNEKCSLAAEKSFRCKLSL--GNKK-KLLKVAALPYE--------------------- -----CGP---PTL-H-HGIPQLFYCLHEI-QEEAFVSQILSDCQKA------------- -----AL-IIS-RNKDMQASA-----FC-LKHCRHLRNLELTIT-LTITQLYALNPD-PL Q----------STE-PGSSNQC-FLWWQDFCSVVR-THEN--LEVLAVTNTVMEADSVKV L------SAALRHP------GCKLQKLIFRRV-------------NT-----S--MLNED LLQVLM------------------ENWYLRCLEIQGT-EVRC-EAMEFLCTALKYPQCYL QCLRL-EDCAVTPKSW--VELARDLGSN-RHL-KTLMLR-SSCLETFGAYYLS------- -LA-QLERLL-------------------------------------------------- -----------LENCGLTVLS----CKSLMSSLMSNKM-LTHL----------------- --------------------------------------------SLAENALKDEGAKQLC SALQHPMCPLQRL----------------------------------------------- ---------VLRNCALTSDCCQDMASALGKN-KNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGFNS-LKDDGVTLLFE A----------------------------------------------------------- --------------------------LKKSESG--------------------------- -----------------------------------------------------------L QIL--ELERCLFTSLCCQ-------------------------------------AMASM LLH---NQS---------------------------------LRYLDVSKND-IGLRGIL LLREAFQ-----QHKWK---KKVVL----------------------------------- ------------------------------------------------------ >M_musculus_ENSMUSP00000041908 ------------------------------------------------------------ -----------------------MASFISDFGLIWYLRELNKKEFMKFKDFLIQEILE-- ----L-KLK-QVSSTKVKKASREDL-ANLLLK-CGE-NQAWDMTFRIL-----QKINRKD LTERATGA-----------------------------IV--------------------- ------------------------------------------------------------ --------GN-------------------------------------------------- ----PNLYRDHLKKKLTHDCPKKFNVRIQDFIKETFIQ---NDYD--------------- -------------AFENLL-ISKGTERKPHM--VFLKGMAGVGKTLMLK-NLMLAWSKGL VFQNKFSYAFYFCCQDVKQ-LKTAS--LAELISRE--WPSPSAPIEEILSQ-PEKLLFII DSLEGMEWD------LT--KQES----ELCDDCMEKQPVSTLLSSLLRRKMLPESSLLLS TTPETFEKMEDRIQCTDVKTATAFDERSMKIYFHRLFQDRK---------RAQEAFSLVR ENKQLFTICQVPLLCWMVATCLK-----EEIEKG-GDPVS--LCRRTTSLYTTHIFSLFI PQSAQ----------YPSKKSQDQLQGLCSLAAEGMW-TDTFVFGKEALRRNGIFDSD-I PTL--LDIGMLGKIRE--FENSYIFLHP-SVQEVCAAIFYMLKRHVEHP--S-------- --------------------------QDVKNI--ETV--LFMFLKKV-KTQWIFLGCFIF GLLQKSEQEKLGVFFGHRLSK--NIHH-KLYQCLETLSG--------------------- -----NAE---LQE-Q-IDGMRLFSCLFEM-EDEAFLVKAMNCMQQI------------- -----NF-VAK-NYSDFIVAA-----YC-LKHCSTLKKLSFSTE-NVLNE-GDQSYME-- --------------------EL-LICWNNMCSVFV-RSKD--IQELRIKDTNFNEPAIRV L------YESLKYP------SFTLNKLVANNV-------------SF---------GDNH VLFELI------------------QNSSLQYLDLSCS-FLSH-NEVKLLCDILNQAECNI EKLMI-AHCKLSPDDC--KIFGSILMSS-KSL-KVLNLA-SNNL-NQGISSLCKALC--H -PHCTLEYLV-------------------------------------------------- -----------LSNCSLSEQC----WDYLSEVLRQNKT-LSHL----------------- --------------------------------------------DISSNDLKDEGLKILC RSLILPYCVLESL----------------------------------------------- ---------CLSCCGITERGCQDLAEVLKNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KYLHVSYNK-LKDTGVMLLCD A----------------------------------------------------------- --------------------------IKHPNCH--------------------------- -----------------------------------------------------------L KDL--QLEACEITDASNE-------------------------------------ELCYA FMQ---CET---------------------------------LQTLNLMGNA-FEVSRMV FFPRK-------SELMLFIFLHLSR----L-WITDFDNEFQAFLLSVKKKNHFLT---IR GSVEADGEKKGGDSDARTMGELSNEI---------------------------- >M_musculus_ENSMUSP00000075794 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFMKFKELLQQEILQ-- ----L-GLK-HISWTEVKKASREDL-ANLLLKHYEE-KKAWDMTFKIF-----QKMNRQD LMERAGRE-----------------------------IA--------------------- ------------------------------------------------------------ --------GH-------------------------------------------------- ----SKLYQVHLKKKLTHDYARKFNIKDQDSLKQKFTQ---DDCD--------------- -------------HFENLL-ISKATGKKPHM--VFLQGVAGIGKSLMLT-KLMLAWSEGM VFQNKFSYIFYFCCQDVKK-MKRAS--LAELISKE--WPNASAPIEEILSQ-PEKLLFVI DNLEVMECD------MS--EWES----ELCDDCMEKQPVNILMSSLLRRKMLPESSFLVS ATPETFEKIEDRIECTNVKMMAGFNESSIKVYFYSLFQDRN---------RTQEIFSLVR ENEQLFSVCQVPVLCWMVATCLK-----KEIEKG-RDPVS--ICRRITSLYTTYIFNLFI PHSAQ----------YPSKKSQDQLQGLCSLAAEGMW-TDTFVFAEEALRRNGIMDSD-I STL--LDVRILEKSKE--SEKSYIFLHP-SIQEVCAAIFHLLKSHVDHP--S-------- --------------------------QDVKSI--EAL--IFTFLKKV-KIQWIFFGSFIF GLLHESEQKKLEAFFGHQLSQ--EIKR-QLYQCLETISG--------------------- -----NKE---LQE-Q-IDGMKLFYCLFEM-DDEAFLPQVMNCMEQI------------- -----KF-VAK-DYSDVIVAA-----HC-LQHCSTLKKLSLSTQ-NILSEGQEHSYTE-- --------------------KL-LICWHHVCSVLT-SSKD--IHVLQVKDTNFNERAFLV L------YSHLKYP------SCILKVLEVNNV-------------TL--------LCDNR LLFELI------------------QNQRLQLLNLSLT-FLSH-NDVKLLCDVLNQAECNI EKLMV-ADCNLSPDDC--KVFVSVLISS-KML-KHLNLS-SNNL-DKGISSLSKALC--H -PDCVLKNLV-------------------------------------------------- -----------LAKCSLSEEC----WHYLSEVLRRNKT-LTHL----------------- --------------------------------------------DISFNDLKDEGLKVLC GALTLPDSVLISL----------------------------------------------- ---------SVRYCLITTSGCQDLAEVLRNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------RNLQISNNK-IEDAGVKLLCD A----------------------------------------------------------- --------------------------IKHPNCH--------------------------- -----------------------------------------------------------L ENI--GLEACALTGACCE-------------------------------------DLASS FTH---CKT---------------------------------LLGINLQENA-LDHSGLV ALFEAMK-----QQQCT---VNLRG----L-RITDFDKETQEFLMAEKEKNPYLS---I- ------------------------------------------------------ >R_norvegicus_ENSRNOP00000038641 ------------------------------------------------------------ -----------------------MASLFSDFGFMWYWKELNKVEFMKFKELLILEILQ-- ----M-GLK-QISWTEVKNASREDL-AILLVKYCEG-KQAWDTTFKVL-----QKISRHD LTERATGE-----------------------------IA--------------------- ------------------------------------------------------------ --------AH-------------------------------------------------- ----ANIYRAHLKKKLTRDCSRKFSISIQN-----FFQ---DEYD--------------- -------------HLENLL-IPKVTEEKPQL--VFLKGIAGIGKTILLK-NLMIVWSEGL VFQNKFSYIFYFCCQDVKQ-LKTTS--LTELISRE--WPSSSAPIEEILSQ-PEKLLFII DSLEGMEWD------FT--KQES----ELCDNCLEKQPVNVLLSSLLKKKILPESSLLIS ATFETFEELKDWIEYTNVRTITGFKESNIKMYFHSLFQDRN---------RALEAFSFVR ENEQLFTLCQAPVICCMVATCLK-----NEIEKG-KDPVS--ICRRTTSLYTTHIFNLFI PPNVQ----------YPSKKSQDQLQGLCFLAVEGMW-TDISVFSEETLRRNGILDSD-I PTL--LDIGILEQSRE--SQNSYIFFHP-SVQEFCAAMFYLLQTHMNHP--S-------- --------------------------PDVLHV--EKL--LFSFLKEV-NTQWIFLGRFIF GLLNELEHEKLEAFFGYQLSQ--QLKQ-ELFEWLELLLD--------------------- -----------PEV-K-VNTMKFFYCLFEM-EEEVFVQSAMNCREEI------------- -----DV-VAK-DYYDFIVAA-----YC-LNHGSALRDLSISTQ-NVLNEKLNQRYME-- --------------------NL-LMLWHNICSVFA-RNKD--IHILQMKDTIFNEPVFQI L------YNYLKNS------SCILEVLVANDV-------------SF--------LCDKY LFFDLI------------------QSYNLELLDLSGT-FLSH-SDVVILCNILNKAEYKI QE---------------------------------------------------------- --------LE-------------------------------------------------- -----------LANCSLSEQS----WKYISDVLCQNKT-LRHL----------------- --------------------------------------------DISSNDLKDEGLKVLC KALTLPDSVLLTL----------------------------------------------- ---------S-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LEACELTGACCE-------------------------------------DLAST FTQ---CKT---------------------------------LGWINLVKNA-LDFNGLV VLCKALK-----QKTSN---LKELR----L-RITDFDNKSQTFLLSEEKGNKFLN---IE NDE--------------------------------------------------- >M_musculus_ENSMUSP00000046503 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFMKFKEFLKQEILQ-- ----L-RLK-QISWTEVKKASREDL-ANLLLKHYEE-KKAWDMTFKIF-----QKMNRKD LMERAGRE-----------------------------IA--------------------- ------------------------------------------------------------ --------GH-------------------------------------------------- ----SKLYQAHLKKKLTHDYARKFNIKVQDFSKQKFTQ---DDYD--------------- -------------RFENFL-ISKVTAKKPHM--VFLQGAAGIGKSLMLT-KLMLAWSEGM VFQNKFSYIFYFCCQDVKK-MKRAS--LAELISKE--WPKTSAPIEDILSQ-PEKLLFVI DNLEVMECD------MS--ERES----ELCDTCTEKQPVRILLSSLLRRKMLPKSSFLIS ATPETFEKMEGRVECTNVKIVTGFNESNIKMYFRSLFQDKT---------KTQEIFSLVK ENQQLFTVCQVPVLCWMVATCLK-----KEIEKG-RDLVS--VCRRTTSLYTTHIFNLFI PQSAQ----------YPSKESQAQLQSLCSLAAEGMW-TDTFVFGEEALRRNGIMDSD-I PTL--LDVRILEKSKK--SEKSYIFLHP-SIQEVCAAIFYLLKSHMDHP--S-------- --------------------------QDVKSI--EAL--IFTFLKKV-KVQWIFFGSFIF GLLHESEQKKLEAFFGHQLSQ--EIKR-QLYQCLETISG--------------------- -----NEE---LQE-Q-VDGMKLFYCLFEM-DDEAFLAQAMNCMEQI------------- -----NF-VAK-DYSDVIVAA-----HC-LQHCSTLKKLSLSTQ-NVLSEGQEHSYTE-- --------------------KL-LMCWHHMCSVLI-SSKD--IYILQVKNTNLNETASLV L------YSHLMYP------SCTLKALVVNNV-------------TF--------LCDNR LFFELI------------------QNQCLQHLDLNLT-FLSH-GDVKLLCDVLSQEECNI EKLMV-AACNLSPDDC--KVFASVLISS-KML-KHLNLS-SNNL-DKGISSLSKALC--H -PDCVLKNLV-------------------------------------------------- -----------LVNCSLSEQC----WDYLSEVLRRNKT-LNHL----------------- --------------------------------------------DISSNDLKDEGLKVLC GALSLPDSVLKSL----------------------------------------------- ---------SVRYCLITTSGCQDLAEVLRKN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------RNLQVSNNK-IEDAGVKLLCD A----------------------------------------------------------- --------------------------IKHPNCH--------------------------- -----------------------------------------------------------L ENI--GLEACALTGACCE-------------------------------------DLASA FTH---CKT---------------------------------LWGINLQENA-LDHSGLI VLFEALK-----QQQCT---LHVLG----L-RITDFDKETQELLMAEEEKNPHLS---IL SSV--------------------------------------------------- >R_norvegicus_ENSRNOP00000051298 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFMKFKEFLKQEILQ-- ----L-GLK-QVSWTEVKKASREDL-ASLLLKHYEE-KQAWDMTFNFF-----QKINRKD LIKRAKRE-----------------------------ID--------------------- ------------------------------------------------------------ --------GY-------------------------------------------------- ----PKLYRAHLKTKLTHDSSRIFNINIQDFLKEKFTK---DDHD--------------- -------------RFETLL-QSKGTESKPQV--VVLSGVAGIGKTLMLK-RLMLAWIEGL VFPYKFSYIFYFCCQEVKQ-LKTAS--LAELISRE--WPDPSAPIEEILSE-PEKLLFII DSLEGIECD------LF--KCDS----ELCDNCMEKQPVNILLSSLLRKKMLLEASLLIS TTPETFEKMEDRIEYTHVKIITGLNESDIKMCFHRLFQDRN---------RAQEAFSLVR ENEQMLTICQVPVLCWMVATCLK-----TEIEKG-RNLVS--TCRRTTSLYTTYIFNLFI PQSAH----------SPSKKSQDQLQGLCSLAAEGIW-TDTFVFTEEALRRNGILDSD-I PTL--LDIGMLGKMGK--FENCYIFLHP-SLQEACAAIFYLLKSHGDHP--I-------- --------------------------EDVKSV--EAL--LFTFLKKA-KVQWILGGRFIF GLLHESEQKKLEAFFGHQLSQ--EIKH-QLYQCLETISV--------------------- -----NEE---LQE-Q-IDGMKLFYCLFEM-EDEDFLMEAMNYMEQI------------- -----NF-VAK-DYSDVIVAA-----YC-LKHCYTLKKLSFSTQ-NILNEEHEHSCME-- --------------------NL-LTCWRHICSVLI-NSKD--IQELQIKDTNLNEPAFSV L------YNSLKYC------NDTLKVLVENNV-------------FF--------LCEKY LFFELI------------------QNCNLQHLNLNLT-FLSH-SDVKLLCDVLNQAECNI EKLEV-AACNLSPDDC--KMFASILMSS-KTL-KQLNLS-SNIL-GKGISSLCKSLC--H -PDCILEHLV-------------------------------------------------- -----------LAKCSLSDQC----WDYLSDGIRQNKT-LNHL----------------- --------------------------------------------DISSNDLKDEGLKVLC RALALPNSVLKSL----------------------------------------------- ---------CLRHCLITTSGCQDLAEVLRNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------TSLQISYNK-IEDAGVKLLCD A----------------------------------------------------------- --------------------------IKQPNCH--------------------------- -----------------------------------------------------------L EDL--GLEACELTGACCE-------------------------------------DLAST FTQ---CRT---------------------------------LWGINLLNNT-LDYTGLV VLCEALR-----QQKCT---PHVLG----L-RITDFDNETQAFLVAEQEKNPDLS---IL SGV--------------------------------------------------- >H_sapiens_ENSP00000375063 -------------MKVAGGLELGAAALLSASPRALVTLSTGPTCSILPKNP--------- ------LFPQNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSE-- ----S-TTC-SIPQFEIENANVECL-ALLLHEYYGA-SLAWATSISIF-----ENMNLRT LSEKARDD-----------------------------MKRHS----PEDPEATMTDQGPS KEKVPGISQAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETE E---QGHGGD-------------------------------------------------- ----TWDYKSHVMTKFAEEEDVRRSFENTAADW--------PEMQ--------------- -------------TLAGAFDSDRW-GFRPRT--VVLHGKSGIGKSALAR-RIVLCWAQGG LYQGMFSYVFFLPVREMQR-KKESS--VTEFISRE--WPDSQAPVTEIMSR-PERLLFII DGFDDLGSV------L---NNDT----KLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVT VRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEH---------QKTQGLRAIM NNRELLDQCQVPAVGSLICVALQ-----LQDVVG-ESVAP--FNQTLTGLHAAFVFHQLT PRGVVR--------RCLNLEERVVLKRFCRMAVEGVW-NRKSVFDGDDLMVQGLGESE-L RAL--FHMNILLPDSH--CEEYYTFFHL-SLQDFCAALYYVLEGLEIEP--A-------- --------------------------LCPLYV--EKTKRSMELKQAGFHIHSLWMKRFLF GLVSEDVRRPLEVLLGCPVPL--GVKQ-KLLHWVSLLGQ--------------------- -----QPN---ATT-P-GDTLDAFHCLFET-QDKEFVRLALNSFQEV------------- -----WL-PIN-QNLDLIASS-----FC-LQHCPYLRKIRVDVK-GIFPRDESAEACP-V V----------PLW-MRDKTLI-EEQWEDFCSMLG-THPH--LRQLDLGSSILTERAMKT L------CAKLRHP------TCKIQTLMFRNA-------------QI-----T--PGVQH LWRIVM------------------ANRNLRSLNLGGT-HLKE-EDVRMACEALKHPKCLL ESLRL-DCCGLTHACY--LKISQILTTS-PSL-KSLSLA-GNKVTDQGVMPLSDALR--V -SQCALQKLILEDCGI---TATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMR LPHC-SLQRLMLNQCHLDTAG----CGFLALALMGNSW-LTHL----------------- --------------------------------------------SLSMNPVEDNGVKLLC EVMREPSCHLQDL----------------------------------------------- ---------ELVKCHLTAACCESLSCVISRS-RHL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLTDNA-LGDGGVAALCE G----------------------------------------------------------- --------------------------LKQKNSV--------------------------- -----------------------------------------------------------L ARL--GLKACGLTSDCCE-------------------------------------ALSLA LSC---NRH---------------------------------LTSLNLVQNN-FSPKGMM KLCSAFA-----CPTSN---LQIIG----L-WKWQYPVQIRKLLEEVQLLKPRVV---ID GSWHSFDEDDRYWWKN-------------------------------------- >P_pygmaeus_ENSPPYP00000011695 -------------MKIAGGLELGAVALL-ASPRDLVTLSTGPTCSILPKNP--------- ------LFPKNLSSQPCIKMEGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSE-- ----S-TTC-SIPQFEIENANVECL-ALLLHEYYGA-SLAWAMSISIF-----ENMNLRT LSEKARDD-----------------------------MKRHS----PEDLEATTTDQGPS KEKVPGISQAVQQHSATAAET-EQEISQAMEQEGAT-AETEEQEISQAMEQEDATAAETE E---QGPGGD-------------------------------------------------- ----KWDYKSHVMTKFTEKEVVRRSFEKTAADL--------PEMQ--------------- -------------MLAGAFNSDQW-GFRPRT--VVLHGKSGIGKTALAR-RIVLCWAQGG LYQGMFSYVFFLPVREMQQ-KKESS--VTEFISRE--WPDSQAPVTEIMSR-PERLLFII DGFDDLGSV------L---NNDT----KLCKDWAEKQPPFILISSLLRKVLLPESFLIIT VRDVGIEKLKSEVVSPRYLLVRGISAEQRIHLLLERGIGEH---------QKTQGLRVIM NNRKLFDQCQVPAVGSLICVALQ-----LQDVVG-ESVAP--FNQTLTGLYAAFVFNQLT PRGVVR--------RCLNREERVVLKRFCRMAVEGVW-NRKSVFDGDDLMVQGLGESE-L RAL--FHMNILVPDSH--CEEYYTFFHL-SLQDFCAALYYVLEGLEIEP--A-------- --------------------------LCPLYV--EKTKRSMEFKQAGFHIHSLWMKRFLF GLVSEDVRRPLEVLLGCPVPL--GVKQ-KLLHWVSLLGQ--------------------- -----QPN---ATT-P-GDTLDAFHCLFET-QDKEFVRLALNSFQEV------------- -----WL-PIN-QNLDLIASS-----FC-LQNCPYLQKIRVDVK-GIFPRDESAEACP-V V----------PLW-MRGKTLI-EEQWEDFCSVLG-THPH--LRQLDLGSSILTERAMKT L------CAKLRHH------TCKIQTLMFRSA-------------QI-----T--PGVQH LWRTLI------------------ANRNLRSLNLGGT-HLKE-EDVRMACEALKHPKCLL ESLRL-DCCGLPHACY--LKISQTLTTP-PSL-KSLSLA-GNKVTDQGVTPLSDALR--V SSQCTLQKLILQDCGI---TATGCQSLASALVSNRSLTHLCLSNNGLGNEGVNLLCRSMR LPHC-SLQRLMLNQCHLDTAG----CGFLALALMGNSW-LTHL----------------- --------------------------------------------SLSMNPVENNGVKLLC EVMREPSCHLQDL----------------------------------------------- ---------ELIKCHLTAACCESLSCVISRS-RHL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLTDNA-LGDGGVAALCE G----------------------------------------------------------- --------------------------LKQKKSV--------------------------- -----------------------------------------------------------L TRL--GLKACGLTSDCCE-------------------------------------ALSLA LSC---NQH---------------------------------LTSLNLVQNN-FSPKGMM KLCSAFA-----CPTSH---LQIIG----L-WKWQYPVQI-KLLEEVQLLKPRVV---ID GSWHSFDEDDRYWWKN-------------------------------------- >C_familiaris_ENSCAFP00000003655 ------------------------------------------------------------ ------------------SQDKMTESFFSDFGLLWYLEELKKEEFWKFKELLKQEPLQ-- ----L-GLK-PIPWTELKKASREDL-AKMLDKHYPG-KQAWDVTLNLF-----LQINRHD LWTKAQEE-----------------------------IRNSGSRMNPDGPLTWKTHSDS- ------------------------------------------------------------ ----QSTLNK-------------------------------------------------- ----PSPYRNHMKEKFRLIWEKETCLPVPNDFYKETIK---HEYE--------------- -------------NLHAAYRAS-QAEESSPT--VVLQGPEGIGKTTLLR-KVMLEWAEGN LWKDRFTFIFFLNGCEMNM-ITETS--LVELISRD--LPLSSEPVEDILSQ-PERILFIM DGFEELKFD------L---ELST----PLCNDQRQRQPMQIILSSLLQRKMLPESSLLIA LGTEGMRKNYCLLQHPKYITLPGFSEHERKLYFYHFFRERN---------KALKAFSFVR GNIPLFVFCHNPLVCWLVCTCMK-----WQLEKG-EDLEI--VSESTTSLYTSFFISVFQ SRNET----------CPPKHSRTRLKGLCTLAAMGVW-TRMFVFCHEDLRRNGISESD-T LMW--MGMRILQRSG-----EYFTFTHM-CLQEFCAAMFYVLKQPKDSP--N-------- --------------------------PAIGSV--TQL--VTAGVSQV-QSPLSRMITFLF AFSTEKITNLLETSFGFLLSK--ELKQ-EITQCLKSLSQ--------------------- -----CDP---NQV-A-VNFQELFSGLFET-HEKGFVAQVMDFFEEV------------- -----NI-YIG-NTEDLVISA-----FC-LKHCQNLRTLHLCIE-NVFSARIPLESQH-- -----------LCS-LIDS-EK-LSFWQDFCSVFT-TNEN--FQMLDLDNCKFSEASLAI L------CKALAQP------VCKLQKVFLCWV-------------Q------YHDGRDDT LHKAIL------------------HNPHLKHLNLHGS-SLSH-VDVRQLCEMLKHPTCSI EELML-GMCDITAEAC--EEIASVLVCN-KKL-KLLSLA-ENPLRNEGMLMLCDALK--H -PDCVLETLLQGNQML---TEGGCRADSVMLISLKKVSGICLPGT------YAFFLDVIQ HIPPNNKYTISLMCCCLTSVA----CDYISQALLCNKS-LSFL----------------- --------------------------------------------DLESNFLKDDGVASLC EALKHPNCHIEQL----------------------------------------------- ---------WLADCSLTSLCCKNLSDVLVCN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------KILKLGSND-IQDAGVKQLCE A----------------------------------------------------------- --------------------------LKHPDCK--------------------------- -----------------------------------------------------------V EHL--GLDMCQLTTACCE-------------------------------------ALASA LTV---CKS---------------------------------LKSLNLHWIS-LDRDGAV VLCEALN-----HLDCA---LQQLG----L-DKSVFDKEIQMLLTAVEEKNPHLT---IS HLLWINKEYRIRDCNTWWWGL--------------------------------- >M_musculus_ENSMUSP00000066841 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFVKFKEFLKQEVLQ-- ----L-GLK-QVSWTEVKKASRQDL-ASLLLKHYEE-KPAWDMTFRFF-----QKINRKD LIERAKRE-----------------------------ID--------------------- ------------------------------------------------------------ --------GC-------------------------------------------------- ----PKLYRAHMKTKMTHDSSRAFTISIQNFLKEKFTE---DDYD--------------- -------------CFENLF-QSKGTESKPQV--VFLSGGAGVGKTLMLK-RLMLAWIESP VFLHKFSYIFYFCCREVKQ-LKTAS--LAELISRE--WPGPSAPIEEILSK-PEKLLFII DSLEGMECD------LF--KWES----ELCDNCTEKQPVNVLLSSLLRRKMLPESSLLIS ATPESFEKMENRIEYTHVKIIKGLKERNIKMSFHRLFQDRN---------RAHEAFSLVR ENEQLFTVCQVPVLCWMVATCLK-----EEIEKG-RDPVS--ICRCTTSLYTTHIFNLFI PQNAH----------SPSKKSQDQLQGLCSLAAEGMW-TDTFVFGEEALRRNGIMDSD-I PIL--LDIGMLINIRE--SEKSYIFLHP-SVQEVCAAIFYLLKSHVDHP--S-------- --------------------------QEVKSI--EKL--MFAFLKKV-KVQWIFFGSFIF GLLHESEQKKLEAFFGHQLSQ--EIKR-QLYQCLETISG--------------------- -----NEE---LQE-Q-IDGMKLFYCLFEM-DDDTFLVEAMNCMEQI------------- -----NF-VAK-DYSDVIVAA-----HC-LKHCFTLKKLSFSTQ-NVLSGAQEHSYME-- --------------------RL-LTAWNHICSVFI-ISKD--IQELRMKDTNLSESAFSV L------YNNLKYH------NYTLNVLVANNV-------------FF--------VCEKY LFFELI------------------QNCNLQHLNLSLT-ILSH-SDVKLLCDVLSQAECNI EELVV-AACSISSDDC--KVFASVLISN-KTL-KHLNLA-SNTL-DKGIASLCKSLC--H -PDCILEHLV-------------------------------------------------- -----------LANCSLNEKC----WDYLSEVLRRNKT-LSHL----------------- --------------------------------------------DISSNDLKDEGLKVLC RALTLPDSVLKSL----------------------------------------------- ---------SLRHCLITISGCQDLAEVLRNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------VSLQVSNNK-LEDTGVKLLCD A----------------------------------------------------------- --------------------------IKHPNCH--------------------------- -----------------------------------------------------------L EDL--GLEACELTGACCE-------------------------------------DLAST FTQ---CKT---------------------------------LWAMNLLKNA-LDYNGLV VLCEALK-----QQTCA---TYVLG----L-QITDFDTETQAFLVAEQEKNPCLR---IL SSL--------------------------------------------------- >C_familiaris_ENSCAFP00000003831 ------------------------------------------------------------ ----------------------MEPSAQLGFNLQPLLEQFAQDELSQFKSLLRPLSLQ-- ----D-ELQ-HIPATEVEEADGKQL-AEILINHCPS-HWVEMVTIQIF-----DKMNRTD LSERAKDELRVKIMKRSNHRKPEETWITRTTELKCANLEEPPEHVEEKDSAFTQVQEEDV TNPEEAKEGLK------------------------------------------------- ----GEKPGK-------------------------------------------------- ----QDKYISILKEKVQQMWKKNFWPGASENIH-TVTQ----KYE--------------- -------------TLIPFCNPKMLAGPFPHT--VVLHGPAGVGKTTLAK-KCMLDWTEDS LAQ-TCPTAFYLSCKALSR-KGMCS--FIELLAQS--APDLQDALAQVLTQ-AQKLLFVI DAFEELRVP------SGVEALVH----DLCVDWKTQRPASTLLGSLLKRKLLPTAALLVT TRPEALRELRLMVEQPLFVEIEGLSECDRKAYFLRHFGEEA---------QALRAFHLMK SNATLFQMGAAPAVCWMVCTCLK-----LQMDEG-EDPGP--TCQTTTSLLLRFLCSQFA PAQGS----------CLGLHLRSTLHALCLLATEGVW-TQTSVFDGHDLLRLGVHESD-L HPF--LNRNILQKSRD--CEGCYCFLHL-SVQQFLAAALYILGSQDHQDLPA-------- ---------GS-------------PSWDAGNV--QRL--LSKEEGLK-NPYLAPVGHFLF GLTNEKRARELGMTFGCLVST--KVKQ-ELLECRVGSPE--------------------- -----NRP---FSS-V-TDTKETLHCLYES-QEEQLVKEAMVQVTEV------------- -----SL-VFK-DTSDIMHAS-----FC-LKHCESLQKMWLQIE-KGMFLENDAVSESED Q----------ADR-SQNDQHV-LPFWIDFCSMFD-SNKN--LIFLDISQSFLSASSVRI L------CEKITSA------THNLQKVVLKNI-------------FP-----A--DAYRN FCIAFG------------------GHETLTHLTLQGN-DQND--MLPILCEILRHPKCNL QYLRL-VSCSATTQQW--AHLSSSLKIN-QSL-TCLNLT-ANELPDESAKLLCTTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCQLTEAC----CKELSSALIVNQR-LTHL----------------- --------------------------------------------SLAKNTLGDDGVKLLC EGLSYPDCQLQML----------------------------------------------- ---------VLWYCSITSGGCNHLSTLLQQN-SNL------------------------- ------------------------------------------------------------ ---------------------------------------THLDLGLNH-IGITGLKFLCE A----------------------------------------------------------- --------------------------LKNPMCN--------------------------- -----------------------------------------------------------L KCL--WLWGCAITPFSSE-------------------------------------ILSSA LGR---NQS---------------------------------LVTLDLGQNS-LGYSGIK MLCDTLK-----LHCSS---LRTLR----L-KIDESDPRIQKLLKEIQEYDPQLT---IE SDDQDPTNNRPSSHDFIF------------------------------------ >P_pygmaeus_ENSPPYP00000011653 ------------------------------------------------------------ ----------------------M-TSPQLEWTLQTLLEQLNEDELKSFKSLLWALPLE-- ----D-VLQ-KTPWSEVEEADGKKL-AEILVNTSSE-NWIRNATVNIL-----EEMNLME LCKMAKAEMMEYG--QVQETDNPELE----------DAEEDSELAKP------------- ------------------------------------------------------------ ----GVKEGR-------------------------------------------------- ----RNSM-----EKQSLVWKNTFWQGDIDSFHDDVTL----RNL--------------- -------------RFIPFLNPITPRKLTPYT--VVLHGPAGVGKTTLAK-KCMLDWTDCN LSP-TVRYAFYLSCKELSH-MGPCS--FAELISKD--WPELQDDIPSILAQ-AQRILFVV DGLEELKVP------PG--ALIQ----DICGDWEKKKPVPVLLGSLLNRYMLPKAALLVT TRPRALRDLQLLAQQPIYIRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLQGALRTLSFLAAQGLW-AQMSVFHQEDLERLGVQESD-L RLF--LDGDILRQDRV--SKGCYSFIHL-SVQQFFAGLFYALEK-EEED--R-------- ---------DG-------------HAWDIGDI--QKL--LSGEERVR-NPDLIQVGHFLF GLANEKRANELEAAFGCRISP--DIKQ-ELLRCKAHLHA--------------------- -----NKP---L-S-M-TDLKEVLVCLYES-QEEELAKVVVAPFKEI------------- -----SI-HLT-NTSEVMHCS-----FS-LKHCQDLQKLSLQVA-KGVFLENYMDSELDI EFERCTYLT--IPNWARQDLRS-LCLWTDFCSLFS-SNSN--LKFLEVKQSFLSDSSVRI L------CDHITRS------TCHLQKVVIKNV-------------TP-----D--TAYRD FCLAFI------------------GKKTLTHLTLEGH-IEWERTMMLMLCDLLRNHKCNL QYLRL-GGHCATPEQW--AEFFYVLKAN-QSL-KHLHIS-ANVLLDEGAKLLYKTMT--H -PEHFLQMLS-------------------------------------------------- -----------LENCRLTEAS----CKDLAAVLVVSKK-LTHL----------------- --------------------------------------------CLAKNLIGDTGVKFLC EGLSYPECKLQTL----------------------------------------------- ---------VLQQCSITKLGCRYISEALQEA-CSL------------------------- ------------------------------------------------------------ ---------------------------------------TNLDLSLNQ-IA-RGLWILCQ A----------------------------------------------------------- --------------------------LENPNCN--------------------------- -----------------------------------------------------------L KHL--------------------------------------------------------- ------------------------------------------------------------ ------------------------R----L-KSYGTSLEIKKLLEEVKEKNPKLT---ID CNASGAM--APRCCDFFC------------------------------------ >A_carolinensis_ENSACAP00000017210 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------T--VVLFGVAGVGKTLMAR-KIMQDWATRS QSPERFDSVFYLSCRQMNLIVGEVN--LAELILNNHSEPRLGEAINKLLIN-PGKCLFII DGFEELNCS------IK--QEGD----NLSISPYEKKPVELILSSLFCKTLFPESCLMIT TRPNTLESLEDCLPSPRYVRHLGFSEEGKKEYFCKFFGEEE---------LAAQALSYIK RNEALLAISFVPGVCWIICTMMK-----EQLDRAEKDLVP--VSDTLTGVYALYLSHLFK SFCTG-------------SEQLDLMKTLCSLAADGLW-EKKPFLKEEDIRKE-------- -LA--LHGTLFRKDPD--CEGSYSFFHP-SIQEFLAALFYVSEDLSRGT--E-------- --------------------------TTKENM--NI---FLDACHEV-RGDLTLTVQFVF GLLNKEIMKYLKEQFEWNISP--KIKT-DLIEWFQLDTQ--------------------- -----IEF---IRP-N-YGQLERFYSLYEVKEEEEFVKHALNHLTEL------------- -----TLQDLTFTQMDQVVLC-----YC-INNCLNLETLSLYRC-LFLLEECETEKRE-- ------------------------------------KRKD--IY---------------- M------CVCVPSS------RCTCPK-RLDEC-------------G------LNAAGCQH FIPVLS------------------ISQTLRKLTLESN-KLGD-VGVKLLCEGLKHPQCQL ETLSL-ATCELSPACC--GDLSSVLSIS-QTL-RELELE-YNKLEDTGLRLLCEGLK--Q -PQCKLEKLG-------------------------------------------------- -----------LFTCDLTAAC----TKDLASILCCNQT-LAQL----------------- --------------------------------------------FLGGNMLGDSGLKQLC EGLKHSQCKIKKL----------------------------------------------- ---------CLCDTGITAAGCMELSSVLSTS-QAL------------------------- ------------------------------------------------------------ ---------------------------------------EDIDLWQNT-LEDSGLRLLCE G----------------------------------------------------------- --------------------------LKHPDCK--------------------------- -----------------------------------------------------------L EVL--SMWGCKFTSASCG-------------------------------------DLQCV LST---NQN---------------------------------LKKLQLENNK-LGDSGVL LLCEGLK-----HPNCK---LKSIG----------------------------------- ------------------------------------------------------ >M_mulatta_ENSMMUP00000031438 ------------------------------------------------------------ ----------------------MVSSTQVNFNLQALLEQLSQDELSKFKSLLRTVSLG-- ----N-EVQ-KIPQKEVDEADGKQL-AEILISHCHS-YWTELATIQVF-----EKMHRVD LSERAKDELREAALKSFNKHKPLSLGITRK-ERQPVDVEEMLERFKAGTLECTETE-EDV TVL-TEVFKVK------------------------------------------------- ----GEKSDN-------------------------------------------------- ----EDRYRLILKTKFREMWQS--WPGDSKEVH-VMAE----RYR--------------- -------------MLIPFSNPRVLPGPFSHT--VVLHSPAGLGKTTLAN-KLMLDWTEDD LIQ-KFKYAFYLSCRELSR-LGPCS--FAQMVFRD--WPELQDDIPHILAQ-AHKILFVI DGFDELGAP------PG--ALIQ----DICGDWEQQKPVPVLLGSLLKRKMLPKATLLVT TRPRALRDLRFLAEQPIYIRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPAP--TCLTSTGLFLRFLCSQFP Q----------------GAQLRGALRALSLLAAQGLW-AQMSVLHGEDLESAGVQESD-L RLF--LDRDILRQDGV--AKGCYSFIHL-SFQQFLTALFYALEKEEEED--R-------- ---------DG-------------HAWDIGDV--QKL--LSREERLK-NPDLIQAGRFLF GLANEKRVKELEATFGWRMSP--EIKQ-ELLRCDVSRKN--------------------- -----GHF-----T-A-ADLRELLCCLYES-QEDELVKEVMAQFKEI------------- -----SL-HL--NAVDIAPSS-----FC-FKHCQNLQKMSLQVIKKETLPENVAASESNA E----------SER-KRPEPPMCCGLGSGIPSFWW-DHRH--EVPYTLPKYFL---LTCI F------TXCIDSQ------DFTFVFPRFKNI-------------FP-----A--DAYRN LCLALR------------------GHKTVTHLTLQGP-DQKD--MLPALCEVLRHPECNL RYLGL-VSCSATTQQW--ADLSLALEAN-RSL-MCVNLS-DNELLDEGAKLLYTTLR--H -PKCFLQRLS-------------------------------------------------- -----------LENCHLTEAN----CKDLAAVLVVSRE-LTHL----------------- --------------------------------------------CLAKNSLKDTGVKFLC EGLSYPECKLQAL----------------------------------------------- ---------VLWNCDITSDGCCSLAKLLQEK-SSL------------------------- ------------------------------------------------------------ ---------------------------------------SCLDLGLNH-IGVTGVKVLCE A----------------------------------------------------------- --------------------------LSKPLCN--------------------------- -----------------------------------------------------------L RCL--WLWGCSIPPFSCE-------------------------------------DLCSA LSC---NQS---------------------------------LITLDLGQNP-LGSSGVK MLFKTLT-----RP-GT---LQTLR----L-KIDDFNDELHKLLEEIEENNPQLI---ID TEKHDPWKKRPSSHDFMI------------------------------------ >R_norvegicus_ENSRNOP00000031864 ------------------------------------------------------------ -----------------------MASFFSDFGIMWYLKELNKREFVKFKEFLKQEILQ-- ----F-GL--TISCTEVKRATREGL-ANLLLKHYEE-KQAWNITFNIF-----QKLNRTD LIERAKRE-----------------------------IAESIPLM--------------- ------------------------------------------------------------ ----FTDSGH-------------------------------------------------- ----PKLYQAHLKTKLTHDSSRVFTTIIQDLLKENFTQ---NDRA--------------- -------------YFENLL-PSNRTVMRPQV--VVIKGMAGIGKTLILK-KLMFAWSKGL LFQNNFSYIFYFCCQDVKQ-LKTAS--LAELISRE--WPGSSAPIEEILSE-PEKLLFLI DSLEGMEWD------LS--ECES----KLCANCIEMQPVNVVLSSLLMRKILPESSLIIS TTPETFEKMENRIKYTSVRTVTGLNESDIISCFYNLFQDMN---------RALEVFSLVR KNEQLFNICQAPIVCCMIAKCLK-----NEIEKG-KDPIS--LCRHITSLYTTYIFNLFI PQNAQ----------YPSKKSQDQMQGLCFLAAEGMW-TNTFVFSEESLRRNGVMDSD-I PTL--LDIGMLVKIRE--SESSYIFLHP-SVQEVCAAIFYFLKSHEDHP--S-------- --------------------------QYVKCI--DIL--IFMFLKKI-KTEWIFLGCFIF GLLHELEQKKLDAFFGHQLSQ--EIKH-QFYQCLETIRG--------------------- -----NEE---LQE-Q-IDGMKLFYCLFEM-EDEAFLIQAMNCIEQI------------- -----NF-VAK-DYSDIIVAA-----YC-LKHCSTLKKVSFSTQ-NILNEEQEYSSME-- --------------------KL-LTYWNQMCSIFI-SNKD--IQELQIKQTCLSDPAFSV F------YNHWKHR------TCTIKILKANMV-------------SF--------LCEKH LFFEFI------------------QNHNLQYLDFSFT-CLSH-INVELLCDVLNQAECNV EKLVV-EHCNLSPDDC--QNFAFVLMNS-KTL-KILNLA-CNNL-DKGIYSLCKALC--H -PNCILENLV-------------------------------------------------- -----------LDNCSLSEQC----WDYLSDALRQNKI-LCHL----------------- --------------------------------------------DISNNELKDKGLKILC KALTLPNCVLKSL----------------------------------------------- ---------CMTHCLITSSGCQDLAEVLRNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KGLQISNNK-LEDAGVKLLCD A----------------------------------------------------------- --------------------------IKHPNCQ--------------------------- -----------------------------------------------------------L MDL--GLEACEITGASSE-------------------------------------DLSSA FLQ---SNT---------------------------------LGRVNLCGNA-FEISGL- ------------------------------------------------------------ ------------------------------------------------------ >O_anatinus_ENSOANP00000018607 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RLQDVEDENSLLGA----NPEYLRLLLVKEH-------------PG QLGSAGHKQMSATQVDALFDPEEEGRKPFRT--VVLQGAAGIGKTTLAT-KILEDWAAGR LFHGRFDYVFYVSCREMNL-VRERS--VADLISHC--CADKNGPVTDIVWL-PKRLLFIV DGFDELRCS------NE--RSRK----DLCSDCKEKRSTDTLLASLMSKRLLPEASLLIT TRPTTLEKMQALLEQPRWAEILGFAEAERKDYFYRYFKEKK---------LARQAFGFLQ GNDGLFTLCMVPIVCRIVCASLK-----RQMERG-EALTQ--TSQTTTAGYLSYLFGLLR EDGTG-----------PKAPRPLNLRRLCSLTAERIQ-NPKILLEEDDLRRHGLGSSG-S TTF--LKISILKKNHH--PQKFYSFPHL-TFQEFFAAVSYVPTSS--------------- -----------------------------QFV--KKL--VGQYGQFG-SGYLTLTMRFLF GLLNEER---LEKNLGCEISH--KIKK-DLLKWIKAEAS--------------------- ---------------K-SNPLDLFHCLYEI-QEEEFVKRATDHFHSI------------- -----EIGALA-TKLDHTVAS-----FC-VKNCLGVCSVTLSSV-YSAGGKGDDVNAVVE EGLSLGSQHESSHR-LGKCFLP-DAFCQNLSSALH-TDPN--LLELNLSHIALGNAGLRV P------SEGLMDQ------GCRLQKL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_musculus_ENSMUSP00000043881 ------------------------------------------------------------ -----------------------MASLFSDFGFIWYWKELNKIEFMYFKELLIHEILQ-- ----M-GLK-QISWTEVKEASREDL-AILLVKHCDG-NQAWDTTFRVF-----QMIGRNV ITNRATGE-----------------------------IA--------------------- ------------------------------------------------------------ --------AH-------------------------------------------------- ----STIYRAHLKEKLTHDCSRKFNISIQN-----FFQ---DEYD--------------- -------------HLENLL-VPNGTENNPKM--VVLQGVAGIGKTILLK-NLMIVWSEGL VFQNKFSYIFYFCCHDVKQ-LQTAS--LADLISRE--WPSPSAPMEEILSQ-PEKLLFII DSLEGMEWN------VT--QQDS----QLCYNCMEKQPVNVLLSSLLRKKILPESSLLIS TSCETFKDLKDWIEYTNVRTITGFKENNINMCFHSLFQDRN---------IAQEAFSLIR ENEQLFTVCQAPVVCYMVATCLK-----NEIESG-KDPVS--ICRRTTSLYTTHILNLFI PHNAQ----------NPSNNSEDLLDNLCFLAVEGMW-TDISVFNEEALRRNGIMDSD-I PTL--LDIGILEQSRE--SENSYIFLHP-SVQEFCAAMFYLLHSEMDHS--C-------- --------------------------QGVYFI--ETF--LFTFLNKI-KKQWVFLGCFFF GLLHETEQEKLEAFFGYHLSK--ELRR-QLFLWLELLLD--------------------- -----TLH---PDVKK-INTMKFFYCLFEM-EEEVFVQSAMNCREQI------------- -----DV-VVK-GYSDFIVAA-----YC-LSHGSALTDFSISAQ-NVLNEELGQR--G-- --------------------KL-LILWHQICSVFL-RNKD--IKTLRIEDTIFNEPVFKI F------YSYLKNS------SCILKTLVAYNV-------------SF--------LCDKR LFLELI------------------QSYNLEELYLRGT-FLSH-SDVEMLCDILNQAECNI RI---------------------------------------------------------- --------LD-------------------------------------------------- -----------LANCSLCEHS----WDYLSDVLRQNKS-LRYL----------------- --------------------------------------------NISYNNLKDEGLKALC RALTLPNSALHSL----------------------------------------------- ---------S-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LEACQLTGACCK-------------------------------------DLAST FTR---YKC---------------------------------LRRINLAKNS-LGFSGLF VLCKAMK-----DQTCT---LYELK----L-RMADFDSDSQEFLLSEMERNKILS---IE NGV--------------------------------------------------- >B_taurus_ENSBTAP00000017623 ------------------------------------------------------------ -------------------MREAKIAPLSNYGLQWCFEQLGKEEFQTFKALLKEHASE-- ----S-AAC-SFPLVQVDRADAESL-ASLLHEHCRA-SLAWKTSTDIF-----EKMSLSA LSEMARDE-----------------------------MKKYLLAEISEDSAPTKTDQGPS MKEVPGP----------------------------------------------------- ----REDPQD-------------------------------------------------- ----SRDYRIHVMTTFSTRLDTPQRFEEFASEC--------PDAH--------------- -------------ALSGAFNPDSSGGFRPLT--VVLHGPPGVGKSSLAR-RLLLFWAQGD LYKGLFSYVFLLRARDLQG-SRETS--FAELISKE--WPDAPVPVEKVLSQ-PERLLIVV DGLEELELT------FR--DQDS----SLLADWAERQPAPVLAHSLLKKVLLPECALLLT VQDAGLQRLQALLRSPRYLWVGGLSVENRMQLLLGGGKHCR---------RKTCAWHAGA DHQEVLDKCQVPVVCALVREALE-----LQGEPG-KGLPV--PGHTLTGLYATFVFQRLA PKDAGW--------RALSGEERCALKGLCRLAADGVW-NAKFVFDGDDLGVHGLQGPE-L SAL--QQASILLPDGH--CGRGHAFSHL-SLQEFFAALFYVLRGVEGDG--E-------- --------------------------GYPLFP--QSTKSLTELRHIDLNVQLVQMKRFLF GLVSKEVMRALETLLGCPVAP--VAKQ-QLLHWICLLGQ--------------------- -----HPA---AAA-S-PDLLEAFYCLFET-QDDEFVRLALNGFQEV------------- -----WL-QLN-RPMDLTVSS-----FC-LRRCQHLQKVRLDVR-GT-PKDEFAEAWF-G A----------PQG-LKIKTL--DEHWEDLCSVLS-THPN--LRQLDLSGSVLSKEAMKT L------CVKLRQP------ACKIQNLIFKGA-------------RV-----T--PGLRH LWMTLI------------------INRNITRLDLTGC-RLRE-EDVQTACEALRHPQCAL ESLRL-DRCGLTPASC--REISQVLATS-GSL-KSLSLT-GNKVVDQGVKSLCDALK--V -TPCTLQKLILGSCGL---TAATCQDLASALIENQGLTHLSLSGDELGSKGMSLLCRAVK LSSC-GLQKLALNACSLDVAG----CGFLAFALMGNRH-LTHL----------------- --------------------------------------------SLSMNPLEDPGMNLLC EVMMEPSCPLRDL----------------------------------------------- ---------DLVNCRLTASCCKSLSNVITRS-PRL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLAANA-LGDEGIAALCE G----------------------------------------------------------- --------------------------LKQKNT---------------------------- -----------------------------------------------------------L TRL--GLEACGLTSEGCK-------------------------------------ALSAA LTC---SRH---------------------------------LASLNLMRND-LGPRGMT TLCSAFM-----HPTSN---LQTIG----L-WKEQYPARVRRLLEQVQRLKPHVV---IS DAWYTEEEEDGPCWRI-------------------------------------- >R_norvegicus_ENSRNOP00000047433 ------------------------------------------------------------ --------------------MLPATAKDALHRLSTYLEELEAGELKKFKLYLGIAEEL-- ------GQD-KIPRGRMEMAGPLEM-AQLMVAHMGT-KEAWLLALSTF-----ERIHRKD LWERGQGEDL-------------VRA---------------------------------- Q----------------------------------------------------------- ----WSFSNP-------------------------------------------------- ----QITYKDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPIWAQQKLLETGW EHSRTRGHQASPIQMETLFEPDEERPEPPRT--VVLQGAAGMGKSMLTH-KVMLDWADGR LFQDQFDYVFYISCRELNRSHTQCS--VHDLLSSC--WPEHGAPLEDLIRA-PDRLLFII DGFHELHPS------FH--DVQG----PWCHCWEEKRPTELLLGSLIRRLLLPQLSLLIT TRPCALEKLHGLLEHPRHVEILGFSEAEREEYFYRYFHNTG---------QASQVFSFMR DYEPLFTMCFVPMVSWVVCTCLK-----QQLESG-ELLRQ--TSRTTTAVYMFYLLSLMQ PKPGT-----------PTFKVPANQRGLVSLAAEGLW-NQKILFEEEDLGKHGLDGAE-V STF--LNVNIFQKGIK--CEKFYSFIHL-SFQEFFTAMYCALHGREA------------- -------------------------------V--RRA--LAEYGFSE-RNFLAHTVRFLF GLLNEEMRCYLERNLGWTISP--QVKE-EALAWIQNKAR--------------------- -----SEG---STL-Q-HGSLELLSCLYEI-QEEDFIQQALSHFQVV------------- -----VVRNLS-TKMEHVVCS-----FC-ARYCRGTEVLHLYGS-AYSTGAEDGPPEPPG AQTQS------THS-QERNILP-DIYSAYLSATIC-TNSN--LIELALYRNALGSQGVRL L------CQGLRHA------NCKLQNL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >B_taurus_ENSBTAP00000048061 ---------------------------------------------------MGDMNLSSD PSSCPSSPLSPSGVSPPSLESSSSSTLPFRNGVMPFMLSVSAEHLQRFKQLLVEENPR-- ----P-GCS-PLTWDQLKSARCGEL-VHLLTEYFPG-QRAWEMARDIF-----AKMNQTE LCLQTQRE-----------------------------LNEILPNLEPEALSLRKRELTLE ------------------------------------------------------------ ----EDESDK-------------------------------------------------- ----IREYKARVMSEHSTLWDRTSWPGNNVDFFYQEPC---REDT--------------- -------------LLQCLLLPRKPQGRQPKT--VVLQGDAGVGKTTVAK-KVMQQWAENK FYAHKGWLAFYLHCQEMDR-PEEQS--FSELIACK--LSGSPALASRILSH-PEHLLLLL DGFEELTLT------LI--DRRE----DLSEDWSQKMPGSVLLTSLLSKRMLPDATIIVF LRFSLWKTVGPFLNSPSLITLMGFSAPERSRYFRSYFKNRR---------DADAALRFAM GNAVLFSMCRVPVICWLVCSCLK-----QQMERG-SSLPR--AFPNATAVFIHYLSSLLP TRVRH----------VVGETPQEQLKRLCSLAVEGMW-KNQWVFSEMDLKLARLDDRD-V EVF--LGVRVLRRAVA--GGDLIAFAHP-SFQEFFAALLFVLCFPQRLR--N-------- --------------------------FQVLDR--FRIFQLLAHPGRR-KNHLAGMALFLF GLLNDTCALAVEQLFGCKVSL--GNKR-KLLKVATMPPD--------------------- -----GDP---LTP-Q-HGLPQLFYCLHEI-REEVFVGQILHNHRKA------------- -----LL-VIS-KIRDLQVSA-----FC-LKFCRQLRELEVTIS-WAVAKATSLSPG-PL P----------SPQ-PEGSDLR-SLWWQDFCSVFK-THES--LEVLTVRDSVMDTEAVET L------AAALRHP------HCNLRKLIFKRV-------------GS-----L--VVSEG IIRVLV------------------ENQYLRHLQIQDT-EVGC-QVIDALCNTLKHPWCFL QFLRL-EGCPFDPSNG--ADLTRSLKRN-IHL-KTLMLR-RGSLERGEECPPV------- -LAPQLERLS-------------------------------------------------- -----------LENCDLTPLS----CESLAFSLVSNQS-LTHL----------------- --------------------------------------------SLAENALQDDGVKQLW NILQHFPCPLQRL----------------------------------------------- ---------VLRNCALTSECCQDIASALDKN-KTL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLGANR-LRDSGVVLLCQ P----------------------------------------------------------- --------------------------LLNPDSG--------------------------- -----------------------------------------------------------L QVL--ELEECQFTSVCCP-------------------------------------ALTSV LLH---NRT---------------------------------LRYLDLSGNG-VGLQGAK LLQDAAL-----KRVLR---PEVVL----YVP---------------------------- ------------------------------------------------------ >C_familiaris_ENSCAFP00000003638 ------------------------------------------------KNP--------- ------LFHQNSSPQPCTKMREAKLPCFSNYGLQWYFKQLSKEEFQTFKELLMEKASE-- ----L-AVC-SFPWVEVSNANVEHL-ASLLHEHYKE-SLAWKISIHIF-----EEMNLST LSEKARKE-----------------------------MKKYSLTEIPENSTPKKNDQEPN MKEGPGQCECVGKIKYVLSHVKELKISQAIEQDGARAAETKEQEIAIALYTRESCCLPLS N---LGRGGN-------------------------------------------------- ----TWNYKDYVMTKFATKLDEYHGSENFASDY--------PEMQ--------------- -------------TLLGAFNPDQR-GFQPRT--VVLHGKSGIGKSDLAR-RVLLSWAQGK LYQGMFSYVFFLGAREMHC-MKEGS--FAELISRE--WPDYQVPMMDIMSQ-PERLLFVV DGFDDLDFA------FK--DNDP----NLCEDWTDKQPTSVLMHSLLKKVLLPESSLMIT VRDTGIEKLKSMLTSPRYLLVRGISVEKRIQLLCQHTKNEH---------LKTQVLHSVV DNHLLFEECQAPILGSLICEALN-----LQEASG-KSLPP--TCQTLTGLYATFVFHQLT PRDASR--------RCLNQEERAILKNLCLMAMRGVW-NRKFVFYRDDLSVHRLRKSE-L SAL--FQTNILLQDGS--HERCYTFLHV-SLQDFCAALYYILEGLETEW--D-------- --------------------------PYPVFM--ENMRSLVELKQISSNAHLFQMKRFLF GLMSKEVMGALEVLLGCPVPL--VMKQ-GLLCWISLLGQ--------------------- -----QAS---TAT-P-PDSLDAFHCLFET-QDDEFVLLALNSFQEV------------- -----WL-PIN-RRMDLMVSS-----FC-LQRCQYLQKIRMDVC-ESFLKDEFTEAHP-L A----------PQG-MPIKTLA-DEWWESLCLVLS-THPS--LQQLDLSGSTLNEWAMKT L------CIKLRQP------TCKIQNLIFKGA-------------QV-----T--LGLRH LWMTLI------------------TNRNIKCLNLEST-HLKD-EDLMMVCEALRHPNCLL ESLRL-DHCGLTPACC--LVISQILVTS-ISL-KSLSLV-GNKVTNQGIKPLCDALT--A -SQCTLQKMILGKCGL---KAPDCQDLASALISNQSLTHLCLSSNSLGSEGMNLLGRAIK FPNC-GLQRLILNECNLDVAG----CGFLAFALMGNRH-LTHL----------------- --------------------------------------------SLSMNPLEDDGMNLLC EVIMEPSCHLQDL----------------------------------------------- ---------ELVKCHLTAGCCKKLSHVIVRN-KHL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLAVNA-LGDDGVTALCE G----------------------------------------------------------- --------------------------LKHRKAS--------------------------- -----------------------------------------------------------L KRL--GLEACGLTSGCCE-------------------------------------VLASA LLC---SQR---------------------------------LTSLNLMRND-FSPMGMT KLCPAFA-----QPTSN---LQIIG----L-WKWEYPTQIRKLLKEVQLVKPQIV---IG DDWYSFDEDDRYWWKS-------------------------------------- >R_norvegicus_ENSRNOP00000046459 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFVKFKEFPMKEILQ-- ----L-RLK-QISWTKVKKASREDL-ANLLLKHYEE-KQAWDMTFKIF-----QKMNRKD LIERAGRE-----------------------------IA--------------------- ------------------------------------------------------------ --------GH-------------------------------------------------- ----SKLYQAHLKKKLTHDYARKFNIKAQDLFKQKFTQ---DDCD--------------- -------------RFENLL-VSKATGKKPHM--VFLQGVAGIGKSLMLT-KLMLAWSEGI VFQNKFSYIFYFCCQDVKQ-LKRAS--LAELISRE--WPNASAPTAEILSQ-PEKLLFII DSLEVMECN------MS--ERES----ELCDNCTEKQPVSLLLSSLLRRKMLPESSFLIS ATPETFEKMEDRIECTNVKIITGFNENNIKMYFRSLFQDKN---------RTLEAFSLVR ENEQLFNVCQVPVLCWMVATCIK-----KEIEKG-RDPVF--ICRRTTSLYTTHIFNLFT PQNAQ----------YPSKKSQDQLQGLCSLAAEGMW-TDTFVFSEEALRRNGILDSD-I PTL--LDRRILERSKE--SESCYIFLHP-SLQEVCAAVFYLLKSHLDHP--S-------- --------------------------QDVKSV--EAL--LFTFLKKA-KVQWIFLGCFLF GLLHESEQEKLEMFFGHQLSQ--EIKH-QLYQCLETISV--------------------- -----NEE---LQE-Q-IDGMKLFYCLFEM-EDEAFLMQAMNCMEQI------------- -----NF-VAK-DYSDVIVAA-----YC-LKHCSTLKKLSFSTQ-NILSEEQEHSYTE-- --------------------KL-LICWHHMCSVLI-SSKD--IHVLQVKDTNLNETAFWV L------YNHLKYP------SCTLKVLVVNNV-------------TF--------LCDNH LFFELI------------------QNQRLQHLNLSLT-FLSH-SDVKLLCDVLNQAECNI EKLMI-AACNLSPDDC--KVFASVLISS-KML-KHLNLS-SNNL-DKGISSLCKALC--H -PDCILKHLV-------------------------------------------------- -----------LANCSLSEQC----WDYLSEVVRRNKT-LSHL----------------- --------------------------------------------DISSNDLKDEGLKVLC GALTLPDSGLISL----------------------------------------------- ---------SVRHCLITTSGCQDLAEVLRHN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLQVSNNK-IEDAGVKLLCD A----------------------------------------------------------- --------------------------IKQPNCH--------------------------- -----------------------------------------------------------L ENI--GLEACELTGACCK-------------------------------------DLASA FVH---CKT---------------------------------LWGINLLENA-LDHSGLV VLFEALK-----QQKCT---LHVLG----L-RITDFDKETQEFLIAEEEKNPYLS---IL SNV--------------------------------------------------- >M_musculus_ENSMUSP00000065508 ------------------------------------------------------------ -----------------------MASFISDFGLMWYLKELNKKEFIKFKEFLIQEILK-- ----L-KLK-QISWTEVKKASREDL-ANLLLKCYEE-NQAWDMTFNIL-----QKINRKD LTERATEE-----------------------------IADSSPLG--------------- ------------------------------------------------------------ ----LTDSGN-------------------------------------------------- ----PKLYRDHLKKKLTHDCSKKFNVRIQDFIKEIFIQ---NDCD--------------- -------------TFENLL-ISKGTEKKPHM--VFLQGMAGIGKTMMLK-NLMLAWSKGL VFQNKFSYTFYFCCRDVKQ-LKTAS--LAELISRE--WPSPSAPIEEILSQ-PEKLLFII DSLEGMECD------LT--KQES----ELCDNCMEKQPVSILLSSLLTRKMLPESSFLLS TTPETFEKMEDRILCTDVKTATAFDERSIKIYFHRLFQDKI---------RAQEAFSLVR ENEQLFTICQVPLLCWMVATCLK-----EEIEKG-GDPVS--VCRHITSLYTTHILNLFI PQSAQ----------YPSKKSQDQLQGLCSLAAEGMW-TDTFVFGEEALRRNGILDSD-I PTL--LDIGMLGKIRE--FENYYIFLHP-SVQEVCAAIFYLLKSHVDHP--S-------- --------------------------QDVKSI--ETV--LFMFLKKV-KTQWIFLGCFIF GLLQKSEQEKLVVFFGRRLSQ--KIQH-KLYQCLETISG--------------------- -----NAE---LQE-Q-IDGMKLFCCLSEI-EDEAFLVKVMNCMQQI------------- -----NF-VAK-NYSDLILAA-----YC-LKHCSTLKKLSFSTQ-NVLNEKGNQRCMK-- --------------------KL-IICWNDMCSVFV-RSKD--IQVLQIKDTSFNEPAIRI L------YEYLKYP------SFTLNKLVANNV-------------HF--------FGDNH AFFELI------------------QNCSLQYLDLGCS-FLTH-SEVKLLCDVLNQAECNI EKLVV-SHCKLSPDDC--KIFGSVLMSS-KTL-KVLNLA-YNNL-NQGISLLCKALC--H -PDCILEYLV-------------------------------------------------- -----------LANCSLSEQC----WDYLSEVLRQNKT-LSHL----------------- --------------------------------------------DISSNDLKDKGLKILC RALTLPYCALKSL----------------------------------------------- ---------YLNNCQITARGCQDLAKVLRNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------KCLHISNNK-LKDAGLMLLCK A----------------------------------------------------------- --------------------------IKHPNCH--------------------------- -----------------------------------------------------------L EDL--RLEACEITGASNE-------------------------------------DLRYA FMQ---CET---------------------------------LQMINLMGNA-LEMLDY- ------------------------------------------------------------ ------------------------------------------------------ >B_taurus_ENSBTAP00000001428 ------------------------------------------------------------ ----------------APAPSMEPRAAAARELLLGALEDLSQEQLKRFRHKLRDERVD-- ------GR--SIPWGRLERADTLDL-VEQLVHFYGP-ERALDVAKKTL-----KRADVRD ------------------------------------------------------------ ------------------------------------------------------------ --------EY-------------------------------------------------- ----KKKYREHVLRQHAKVKERDAR---SVKINKRFTKLLIAE----------------- EPEAERARRSDTHTFNRLF-GRDEEGERRLT--VALQGPAGIGKTMAAR-KILYDWAAGK LYHSQVDFAFFLSCRELLERPGTCS--LADLILDQ--CPDREAPVQQMLAQ-SERLLFIL DGVDEML-A------PE--PAEA----APCRDPHEAASGARVLGSLLSKELLPAARLLVT RRGATPGRLQARLCSPQCAEVCGFSDKDRKKYFYKFFQDEW---------KAEHAYRSVK ENEMLFSLCFVPGVCWIVCTVLR-----QQLQRG-QDLWR--TSKTTTAVYLLFVASVLR SAPAA-----------DAAQLQRELRKLCRLACDGVL-GGRARFSEEDLERLQLCGSKVQ TQF--LSKKEMPGVLE--TEVTYQFIDQ-SFQEFLAALSYLLEDEGAPR----------- --------------------------APAGSI--EA---LLQGDPEL-RGHLNLTTRFLF GLLNTERMCEIKRHFGCTVSE--RVKQ-RVLRWVQDQGQGRPRAAPEGTEEILAPQD--- -TEE-SEE---EEGEQLNYPLELLYCLHET-QEDAFVHQALRGLPEL------------- -----VLERVHFSRMDLAVLS-----YC-VRCCPAGQALRLVSC-RLATAQE--KK---- ---------------------K-KSLMKRLQG------------SSRATTRKSPGSPLRP L------CEAMTDR------QCGLNSL--------------------------------- ------------------------------------------------------------ ---TL-SRCKLPDSVC--RDLSEALREA-PAL-AELGLF-HNGLSEAGLRVLSEGLA--S -PQCRVQTLR-------------------------------------------------- -----------VQQPGLQEA-----LQYMVGKLQQIPA-LTTL----------------- --------------------------------------------DLSGCQLSGPTVTCLC TTLKCPGCHLQTL----------------------------------------------- ---------RLTSVELSEQALQELQAVETAN-PRL------------------------- ------------------------------------------------------------ ---------------------------------------VITHPALDA-HPKPPTVPISA L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >G_gorilla_ENSGGOP00000010282 ------------------------------------------------------------ ----------------------M-TSPQLEWTLQTLLEQLNEDELKSFKSLLWALPLE-- ----D-VLQ-KTPWSEVEEADGKKL-AEILVNTSSE-NWIRNATVNIL-----EEMNLTE LCKMAKAEMMXXX--XXXXXXXXXXX----------XXXXXXXXXXX------------- ------------------------------------------------------------ ----XXXXXX-------------------------------------------------- ----XXXX-----XXXXXXXXXXXXXXXXXXXXXXXXX----XXX--------------- -------------XXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXLAK-KCMLDWTDCN LSP-TVRYAFYLSCKELSR-MGPCS--FAELISKD--WPELQDDIPSILAQ-AQRILFVV DGLDELKVP------PG--ALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPQAALLVT TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPIP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQMSVFHREDLERLGVQESD-L RLF--LDGDILRQDXV--SKGCYSFIHL-SFQQFFAALFYALEKEEEED--X-------- ---------DG-------------HAWDIGDV--QKL--FSGEERLK-NPDLIQVGHFLF GLANEKRAKELEATFGCRMSP--DXKQ-ELLQCKAHLHA--------------------- -----NKP---L-S-V-TDLKEVLGCLYES-QEEELAKVVVAPLREI------------- -----SI-HLT-NTSEVMHCS-----FS-LKHCQDLQKLSLQVA-KGVFLENYMDFELDI EFE-------------------------------S-SNSN--LKFLEVKQSFLSDSSVRI L------CDHVTRS------TCHLQKVEIKNV-------------TP-----D--TAYRD FCLAFI------------------GKKTLTHLTLAGH-IEWERTMMLMLCDLLRNHKCNL QYLRL-GGHCATPEQW--TEFFYVLKAN-QSL-KHLRLS-ANVLLDEGAKLLYKTMT--R -PKHFLQMLS-------------------------------------------------- -----------LENCRLTEAS----CKDLAAVLVVSKK-LTHL----------------- --------------------------------------------CLAKNPIGDTGVKFLC EGLSYPDCKLQTL----------------------------------------------- ---------VXXXXXXXXXXXXXXXXXXXXX-CSL------------------------- ------------------------------------------------------------ ---------------------------------------TNLDLSINQ-IA-RGLWILCQ A----------------------------------------------------------- --------------------------LENPNCN--------------------------- -----------------------------------------------------------L KHL--RLWSCSLMPFYCQ-------------------------------------HLGSA LLS---NQK---------------------------------LEXLDLGQNH-LWKSGII XLFGVLR-----QRTGS---LKTLR----L-KTYETNLEIKKLLEEVKEKNPKLT---ID CNASGAT--APPCCDFFC------------------------------------ >R_norvegicus_ENSRNOP00000019808 ------------------------------------------------------------ -----------MD---AAGASCSSSEAVARELLLAALQDLSQEQLKRFRHKLRDAPLD-- ------GR--SIPWGRLEHSDAVDL-TDKLIEFYAP-EPAVDVTRKIL-----KKADIRD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KKYREHVLRQHAKVKERNAR---SVKINKRFTKLLIAPGS-GAGEDELLGTSG-- EPEPERARRSDTHTFNRLFRGNDDEGPRPLT--VVLQGPAGIGKTMAAK-KILYDWAGGK LYHSQVDFAFFMPCGELLERPGTRS--LADLILEQ--CPDRTAPVRRILAQ-PHRLLFIL DGADELP-T------LA--APEA----TPCRDPFEATSGLRVLSGLLSQELLPSARLLVT SRNATLGRLQGRLCSPQCAEVRGFSDKDKKKYFFKFFRDER---------KAERAYRFVK ENETLYALCFVPFVCWIVCTVLL-----QQMELG-RDLSR--TSKTTTSVYLLFITSMLK SA-GT-----------NGPRVQGELRMLCRLAREGIL-KHQAQFSEKDLERLKLQGSQVQ TMF--LSKKELPGVLE--TVVTYQFIDQ-SFQEFLAALSYLLDAEGAPG----------- --------------------------NSAGSV--QM---LLNSDAGL-RGHLALTTRFLF GLLSTERIRDIGNHFGCVVPG--RVKQ-DTLRWVQGQSQ--PKVATVGAEKKDELKDEEA EEEEEEEE---EEEEELNFGLELLYCLYET-QEDDFVRQALSSLPEM------------- -----VLERVRLTRMDLEVLS-----YC-VQCCPDGQALRLVSC-GLVAAKEKKKK---- ---------------------K-KSFMNRLKG-------------SQSTGKQPPASLLRP L------CEAMITQ------QCGLSIL--------------------------------- ------------------------------------------------------------ ---TL-SHCKLPDAVC--RDLSEALKVA-PSL-RELGLL-QNRLTEAGLRLLSQGLA--W -PKCKVQTLR-------------------------------------------------- -----------IQMPGLQEV-----IHYLVIVLQQSPV-LTTL----------------- --------------------------------------------DLSGCQLPGTVVEPLC SALKHPKCGLKTL----------------------------------------------- ---------SLTSVELTENPLRELQAVKTLK-PDL------------------------- ------------------------------------------------------------ ---------------------------------------AIIHSKLGT-HPQPLKG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >H_sapiens_ENSP00000291971 ---------------------------------------------------MSDVNPPSD TPIPFSSSSTHSSHIPPWTFSCYPGS-PCENGVMLYMRNVSHEELQRFKQLLLTEL-S-- ----T-GTM-PITWDQVETASWAEV-VHLLIERFPG-RRAWDVTSNIF-----AIMNCDK MCVVVRRE-----------------------------INAILPTLEPEDLNVGETQVNLE ------------------------------------------------------------ ----EGESGK-------------------------------------------------- ----IRRYKSNVMEKFFPIWDITTWPGNQRDFFYQGVH---RHEE--------------- -------------YLPCLLLPKRPQGRQPKT--VAIQGAPGIGKTILAK-KVMFEWARNK FYAHKRWCAFYFHCQEVNQ-TTDQS--FSELIEQK--WPGSQDLVSKIMSK-PDQLLLLL DGFEELTST------LI--DRLE----DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIM IRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTE---------EGDQVLSFAM ENTILFSMCRVPVVCWMVCSGLK-----QQMERG-NNLTQ--SCPNATSVFVRYISSLFP TRAEN----------FSRKIHQAQLEGLCHLAADSMW-HRKWVLGKEDLEEAKLDQTG-V TAF--LGMSILRRIAG--EEDHYVFTLV-TFQEFFAALFYVLCFPQRLK--N-------- --------------------------FHVLSH--VNIQRLIASPRGS-KSYLSHMGLFLF GFLNEACASAVEQSFQCKVSF--GNKR-KLLKVIPLLHK--------------------- -----CDP---PSP-G-SGVPQLFYCLHEI-REEAFVSQALNDYHKV------------- -----VL-RIG-NNKEVQVSA-----FC-LKRCQYLHEVELTVT-LNFMNVWKLSSS-SH P----------GSE-APESNGL-HRWWQDLCSVFA-TNDK--LEVLTMTNSVLGPPFLKA L------AAALRHP------QCKLQKLLLRRV-------------NS-----T--MLNQD LIGVLT------------------GNQHLRYLEIQHV-EVES-KAVKLLCRVLRSPRCRL QCLRL-EDCLATPRIW--TDLGNNLQGN-GHL-KTLILR-KNSLENCGAYYLS------- -VA-QLERLS-------------------------------------------------- -----------IENCNLTQLT----CESLASCLRQSKM-LTHL----------------- --------------------------------------------SLAENALKDEGAKHIW NALPHLRCPLQRL----------------------------------------------- ---------VLRKCDLTFNCCQDMISALCKN-KTL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLSFNS-LKDDGVILLCE A----------------------------------------------------------- --------------------------LKNPDCT--------------------------- -----------------------------------------------------------L QIL--ELENCLFTSICCQ-------------------------------------AMASM LRK---NQH---------------------------------LRHLDLSKNA-IGVYGIL TLCEAFS-----SQKKR---EEVIF----CIPAWTRITSFSPTPHPPDFTGKSDCLSQIN P----------------------------------------------------- >M_musculus_ENSMUSP00000015866 ------------------------------------------------------------ -----------------------MGPPEKESKAILKARGLEEEQKSERKMTSPENDSKSI QKDQGPEQE-QTSESTMGPPEKDSK-AILKARGLEE-EQKSESTMSPS-----ENVSRAI LKDSGSEEVEQ--------------------------ASERKMTSPENDSKSIQKDQGPE QEQTSETLQSKEEDEVTEAD---------------------------------------- ----KDNGGD-------------------------------------------------- ----LQDYKAHVIAKFDTSVDLHYDS---------------PEMK--------------- -------------LLSDAFKPYQK-TFQPHT--IILHGRPGVGKSALAR-SIVLGWAQGK LFQK-MSFVIFFSVREIKW-TEKSS--LAQLIAKE--CPDSWDLVTKIMSQ-PERLLFVI DGLDDMDSV------LQ--HDDM----TLSRDWKDEQPIYILMYSLLRKALLPQSFLIIT TRNTGLEKLKSMVVSPLYILVEGLSASRRSQLVLENISNES---------DRIQVFHSLI ENHQLFDQCQAPSVCSLVCEALQ-----LQKKLG-KRCTL--PCQTLTGLYATLVFHQLT LKRPSQ--------SALSQEEQITLVGLCMMAAEGVW-TMRSVFYDDDLKNYSLKESE-I LAL--FHMNILLQVGHN-SEQCYVFSHL-SLQDFFAALYYVLEGLEEWN----------- --------------------------QHFCFI--ENQRSIMEVKRTD-DTRLLGMKRFLF GLMNKDILKTLEVLFEYPVIP--TVEQ-KLQHWVSLIAQ--------------------- -----QVN---GTS-P-MDTLDAFYCLFES-QDEEFVGGALKRFQEV------------- -----WL-LIN-QKMDLKVSS-----YC-LKHCQNLKAIRVDIR-DLLSVDNTLELCPVV T----------VQE-TQCKPLL-MEWWGNFCSVLG-SLRN--LKELDLGDSILSQRAMKI L------CLELRNQ------SCRIQKLTFKSA-------------EV-----V--SGLKH LWKLLF------------------SNQNLKYLNLGNT-PMKD-DDMKLACEALKHPKCSV ETLRL-DSCELTIIGY--EMISTLLIST-TRL-KCLSLA-KNRVGVKSMISLGNALS--S -SMCLLQKLILDNCGL---TPASCHLLVSALFSNQNLTHLCLSNNSLGTEGVQQLCQFLR NPEC-ALQRLILNHCNIVDDA----YGFLAMRLANNTK-LTHL----------------- --------------------------------------------SLTMNPVGDGAMKLLC EALKEPTCYLQEL----------------------------------------------- ---------ELVDCQLTQNCCEDLACMITTT-KHL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLGNNA-LGDKGVITLCE G----------------------------------------------------------- --------------------------LKQSSSS--------------------------- -----------------------------------------------------------L RRL--GLGACKLTSNCCE-------------------------------------ALSLA ISC---NPH---------------------------------LNSLNLVKND-FSTSGML KLCSAFQ-----CPVSN---LGIIG----L-WKQEYYARVRRQLEEVEFVKPHVV---ID GDWYASDEDDRNWWKN-------------------------------------- >P_troglodytes_ENSPTRP00000019830 ---------------------------------------------------MSDVNPPSD TPIPFSSSSTHSSHIPPWTFSCYPGS-PCENGVMLYMRNVSHEELQRFKQLLLTEL-S-- ----T-GTM-PITWDQVETASWAEV-VHLLIERFPG-RRAWDVTSNIF-----AIMNCDK MCVLVRRE-----------------------------INAILPTLEPEDLNVGETQVNLE ------------------------------------------------------------ ----EGESGK-------------------------------------------------- ----IRRYKSNVMEKFFPIWDFTTWPGNQRDFFYQDVH---RHEE--------------- -------------YLPCLLLPKRPQGRQPKT--VVIQGAPGIGKTILAK-KVMFEWARNK FYAHKRWCAFYFHCQEVNQ-MTDQS--FSELIEQK--WPGSQDLVSKIMSK-PDQLLLLL DGFEELTST------LI--DRLE----DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIM IRFSSWQTCKPLLKCPSLITLPGFNTMEKIKYFQMYFGHTE---------EGDRVLSFAM ENTILFSMCRVPVVCWMVCSGLK-----QQMERG-NNLTH--ACPNATSVFVRYISSLFP TRAEN----------FSRKIHQAQLEGLCHLAADSMW-HRKWVLGKEDLEEAKLDQTG-V TAF--LGMSILRRIAG--EEDHYVFTLV-TFQEFFAALFYVLCFPQRLK--N-------- --------------------------FHVLSH--VNIQRLIASPRGS-KSYLSHMGLFLF GFLNEACASAVEQSFQCKVSF--GNKR-KLLKVIPLLHK--------------------- -----CDP---PSP-G-SGVPQLFYCLHEI-REEAFVSQALNDYHKV------------- -----VL-RIG-NNKEVQVSA-----FC-LKRCQYLHEVELTVT-LNFMNVWKLSSS-SP P----------GSE-APESNGL-HRWWQDLCSVFA-TNDK--LEVLTMTNSVLGPPFLTA L------AASLRHP------QCKLQKLLLRRV-------------NS-----T--MLNQD LIGVLM------------------GNQHLRYLEIQHV-EVES-KAVKLLCRALRSPRCRL QCLRL-EDCLATPRIW--TDLGNNLQGN-GHL-KTLILR-KNSLENCGAYYLS------- -MA-QLERLS-------------------------------------------------- -----------IENCNLTQLT----CESLASCLRQSKM-LTHL----------------- --------------------------------------------SLAENALKDEGAKHIW NALPHLRCPLQRL----------------------------------------------- ---------VLRKCDLTFNCCQDMISALCKN-KTL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLSFNS-LKDDGVILLCE A----------------------------------------------------------- --------------------------LKNPDCT--------------------------- -----------------------------------------------------------L QIL--ELENCLFTSICCQ-------------------------------------AMASM LRK---NQH---------------------------------LRHLDLSKNA-IGVYGIL TLCEAFS-----SQKKR---EEVIF----CIPAWTRITSFSPTPHPPDFTGKSDCLSQIN PYAVQSSFSGA------------------------------------------- >G_gallus_ENSGALP00000008260 ------------------------------------------------------------ ------------------------MAGEESTILLEALEGLTLEDFQEFKKKLPHTDIK-- ------GGW-NIGRDELEKVTHPSSLISYMGDSYGE-GAAMDIAISLF-----EEMNQRD LAEKILDE---------------------------------------------------- ------------------------------------------------------------ -----KVKEY-------------------------------------------------- ----KQKYTEHVAREFLQYKEANSCLGENLSVRDRYTNLTIARKS------------WDQ HGDEPGDVSSDTVTTQTLLEPSKD-GQVPPI--TVLVGASGMGKTMTIR-KVMMEWVEGT LCT-QFDYVFCIDCKELSF-SKEVS--MVDLISKC--CPQQRMPAGRILGN-PEKILFIF DSFEALGLP------LA--QPKD----ELSTDPTEAKPLETTLLSLLRRTVLPESSVLIA TRPAALQSLGQCLEGKHYVEILGFSPAAREEYFHRYFGNDS---------KADVAFRFTR GNEVLYSLCVIPVMSWTVCTVLE-----RELYER-NQLLA--CSKTTTQMIMFYLSWLMK HRVSN-----------AWQNLQQFLHKLCSLAADGIW-KHKVLFEEKEIEDQGLNQPQLL SLF--LNEKGLEKGTD--HVNVYSFSHL-HLQELFAAMFYVLEDQDGMV--S-------- --------------------------DSRILA--KDVNMLLESYHTS-RMDLNVTVRLLF GLVNPKSVEYAGEGIGCRISL--QPQE-DLLRWLQTRPR--------------------- -----GTSHPREVM-K-IEDLDTFHLLFET-NEKSFVQSVLGSFTGI------------- -----ALQDVKLTLYDQAALC-----FC-IKQWAGLLSVTLRSC-SFHQQHHRQEP---- -----------------AKGLP-RQSW---------RQEE-------------LHSPLHP L------CQALGHP------GSSLQSL--------------------------------- ------------------------------------------------------------ ---RL-QWCGLTEGDS--GVLGTLLATL-PSL-VHLELG-DGALGDDGVRMLCAGLR--Q -PGCQLRVLR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >C_familiaris_ENSCAFP00000026585 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------FDPDEEGSSSSQT--VVLQGCAGIGKTAVVH-KFMYDWAAGM VTPGRFDYLIYVNCREINS-IANLS--AADLITNT--FQDIDGPILDVIPMYPEKLLFIL DGFPELQCP------VD--NQEE----DLSANPQEKKPVETLLCSFVRKKLFPESSLLIT ARPTTMKKLHSLLKQHIQAEIVWFTDAEKRAYFLSQFSGAT---------VAMKVFYELQ QNESLDIMSSLPIISWMICRVLQ-----SQGDGD-RTLMR--SLQTVTDVYLFYFSKCLK TLTGI-----------SVWKGQSCLWGLCSLAADGLQ-NQQVLFEVSDLRRHGIGIYD-M NCT--FLNHFLKKVKG--SASVYTFLHF-SFQEFLTAVFYVLKNDSNWMFFG-------- --------------------------QVGKTW--QEI--FQQYG----KGFSSLTIQFLF GLLHKGKGKAVETIFGRKISP--GLRE-ELLKWTEKEIK--------------------- -----DKS---SRL-Q-IEPMDLFHCLYEI-QEEEYTKGIIDDLQSI------------- -----ILLQPTYTKMDILAMS-----FC-VKSSHNHLSVSLKCQ-HLLGFEEEERASAFI P----------PAS-ALNQKRK-KRKNMDIATLLV-VGPGFFISFRSSQLCNLPASRLQL L------CQALCNP------YCKIKDLKFSSV-------------R------SCPFLLQS YSLVFE------------------TNQYLTDLEFVKN-TLED-SGMKLLCEGLRKPNCVL QTLRL-YRCLLSPASC--GALAAVLSTS-QWL-TDLEFS-ETKLDALALKLLCEGLK--D -PNCKLQKLKILNSCRGLNSEVVCKYLASVLICNPNLTELDLSENPLGDTGVKYLCEGLR HSNC-KVEKLELSECSLSAAC----CESLSQVLSSSRS-LTRL----------------- --------------------------------------------LLINNKIEDLGLKLLC EGLKQPDCPLKDL----------------------------------------------- ---------ALWTCHLTGECCQDLCNALYTN-EYL------------------------- ------------------------------------------------------------ ---------------------------------------RDLDLSDNA-LGDEGMQVLCE G----------------------------------------------------------- --------------------------LKQPSCK--------------------------- -----------------------------------------------------------L QTL--WLAECHLTDACCG-------------------------------------ALASV LSR---NEN---------------------------------LTLLDLSGND-LKDFGVQ MLCDALL-----QPICK---LQTF------------------------------------ ------------------------------------------------------ >C_familiaris_ENSCAFP00000009685 ------------------------------------------------------------ -----------MDPPEACCRKVRPTLAVARDLLQATFEDLNQEQLKRFRHKLRDATLD-- ------GR--NIPWGRLDGLDAMDL-AAQLTHFYGP-EPALDVTRKTL-----KRADMLD VAARLKEQQLQRLGPSSSTL---------------------------------------- ------------------------------------------------------------ ----RSVSEY-------------------------------------------------- ----KKKYRDHVLQQHAKVKERNAR---SVKINKRFTKLLIAREG-AALPDEALGCTKEL EPEPQRARRSDTHTFNRLF-GRDEEGQRPLT--VVLQGPAGIGKTMAAK-KILYDWAAGK LYHGQVDFAFFLPCRELLERPGACS--LADLVLDQ--CPQRKAPLKPMLAR-PERLLFIL DGADDLP-P------L---APHA----APCTDPFQAADAARVLGGLLGKTLLPAARLLVT ARTTAPGRLLDRLCSPQCAEVCGFSDKDKKKYFHKFFRDER---------LAERAYRFVK ENETLFALCFVPFVCWIVCTVLR-----QQLELG-QDLSR--TSKTTTSVYLLFIISVLS SAPAA-----------DAPRMRAELRKLCRLAREGTL-GHRAQFAEKDLERLELRGSKVQ TLF--LSKKELPGVLQ--TDVTYQFMDQ-SFQEFFSALSYLLEEE--------------- -----------------------------RDL--RA---LLQG-----ESHLTLTTRFLF GLLNPDRVSDMQRHFGVAVPE--RVKQ-DVLLWMQEQGQGRRRAAPEKTAGTDAAED--- -AEEPEEE-----ECEPNYPLELLYCLYET-QEDAFVRQALRCLPEL------------- -----ELERVRLSRMDLVILS-----YC-VRCCPPGQALRLVSC-GLAPAQ---KK---- ---------------------K-KSLMKRLHSSLGGSS------SSQASKRKPQPSPLRP L------FEAMTDE------HCGLNSL--------------------------------- ------------------------------------------------------------ ---TL-CRCKLPDSVC--HDLSEALREA-PAL-TELGLL-HNQLSEAGLRVLLEGLA--W -PQCRVQKLR-------------------------------------------------- -----------VQQPSLQEA-----PQYIISILRQSVA--STL----------------- --------------------------------------------YLGDCQLPGPVVTSLC AALQHPGCRLQTL----------------------------------------------- ---------TLTSVELSKESLKELQAVKTAK-PGL------------------------- ------------------------------------------------------------ ---------------------------------------VIIHPALDS-HPKPSKGLSDA L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >T_guttata_ENSTGUP00000008037 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TTALFEPGRD-GQTPQV--VVLVGAPGMGKTTMVR-KVMVEWGEGT LHT-QFDFVFCIDCKAITL-PMEAS--VADLVSQC--CPALQVPAGKILDD-QKKILFIF DGFEALGFS------LV--QPEA----ELSSDPREVKPLELTLMSLLKKTVLPKASLLIT MRPMALGSLRQCLKGKHYMEILGFSAARRKEYFHQYFENPR---------KADVAFRFVR GNEILYSLCVIPIMSWTICTILE-----QELCGK-KNLLE--CSKATTGMTMFYLSQLLK HRGRD-----------NPQVLQQFLLQLCSLAAEGIW-KHKVLFEEKEIKDYGLDQPGLL PYF--LNERIPRKGED--NGSVYAFTHL-HLQEFFAALFYVLEDDGETV--S-------- --------------------------SSGRLE--KDVNKLLESY-KS-RKDLNVTVLFLF GLVSQKSMEYMDKTFGCRISP--RARE-ELLEWLQGRHR--------------------- -----GLSHPSQAL-K-ISEMDTFHFLFEM-NEKSFAESALGHFTDL------------- -----DLHDTKLTLYDQMALS-----FC-IQHWAGLGSITLQGC-FFHWQDPEAEL---- -----------------DASVP-WTSW---------CPRR-------------DALPIHL F------CRALRHR------DSALQVL--------------------------------- ------------------------------------------------------------ ---RL-QWCQLSESCC--AELAALLAEH-PGL-AHLEVA-DSSLGDSGVRLLCEGLR--T -AGSRLRILR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_musculus_ENSMUSP00000101660 ------------------------------------------------------------ -----------MD---AAGASCSSVDAVARELLMATLEELSQEQLKRFRHKLRDAPLD-- ------GR--SIPWGRLERSDAVDL-VDKLIEFYEP-VPAVEMTRQVL-----KRSDIRD VASRLKQQQLQKLGP-TSVL---------------------------------------- ------------------------------------------------------------ ----LSVSAF-------------------------------------------------- ----KKKYREHVLRQHAKVKERNAR---SVKINKRFTKLLIAPGT-GAVEDELLGPLG-- EPEPERARRSDTHTFNRLFRGNDEESSQPLT--VVLQGPAGIGKTMAAK-KILYDWAAGK LYHSQVDFAFFMPCGELLERPGKRS--LADLVLDQ--CPDRAWPVKRILAQ-PNRLLFIL DGADELP-T------LP--SSEA----TPCKDPLEATSGLRVLSGLLSQELLPGARLLVT TRHAATGRLQGRLCSPQCAEIRGFSDKDKKKYFFKFFRDER---------KAERAYRFVK ENETLFALCFVPFVCWIVCTVLQ-----QQLELG-RDLSR--TSKTTTSVYLLFITSMLK SA-GT-----------NGPRVQGELRTLCRLAREGILDHHKAQFSEEDLEKLKLRGSQVQ TIF--LNKKEIPGVLK--TEVTYQFIDQ-SFQEFLAALSYLLEAERTPG----------- --------------------------TPAGGV--QK---LLNSDAEL-RGHLALTTRFLF GLLNTEGLRDIGNHFGCVVPD--HVKK-DTLRWVQGQSH--PKGPPVGAKKTAELED--- IEDAEEEE---EEEEDLNFGLELLYCLYET-QEEDFVRQALSSLPEI------------- -----VLERVRLTRMDLEVLN-----YC-VQCCPDGQALRLVSC-GLVAAKEKKKK---- ---------------------K-KSLVKRLKGSVTGTNLVLSLYSSQSTKKQPPVSLLRP L------CETMTTP------KCHLSVL--------------------------------- ------------------------------------------------------------ ---IL-SHCRLPDAVC--RDLSEALKVA-PAL-RELGLL-QSRLTNTGLRLLCEGLA--W -PKCQVKTLR-------------------------------------------------- -----------MQLPDLQEV-----INYLVIVLQQSPV-LTTL----------------- --------------------------------------------DLSGCQLPGVIVEPLC AALKHPKCSLKTL----------------------------------------------- ---------SLTSVELSENSLRDLQAVKTSK-PDL------------------------- ------------------------------------------------------------ ---------------------------------------SIIYSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >H_sapiens_ENSP00000309767 ------------------------------------------------------------ -----------MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPD-- ------GR--SIPWGRLERADAVDL-AEQLAQFYGP-EPALEVARKTL-----KRADARD VAAQLQERRLQRLGLGSGTL---------------------------------------- ------------------------------------------------------------ ----LSVSEY-------------------------------------------------- ----KKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPES-AAP-EEAMGPAE-- EPEPGRARRSDTHTFNRLF-RRDEEGRRPLT--VVLQGPAGIGKTMAAK-KILYDWAAGK LYQGQVDFAFFMPCGELLERPGTRS--LADLILDQ--CPDRGAPVPQMLAQ-PQRLLFIL DGADELP-A------LG--GPEA----APCTDPFEAASGARVLGGLLSKALLPTALLLVT TRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKYFRDER---------RAERAYRFVK ENETLFALCFVPFVCWIVCTVLR-----QQLELG-RDLSR--TSKTTTSVYLLFITSVLS SAPVA-----------DGPRLQGDLRNLCRLAREGVL-GRRAQFAEKELEQLELRGSKVQ TLF--LSKKELPGVLE--TEVTYQFIDQ-SFQEFLAALSYLLEDGGVPR----------- --------------------------TAAGGV--GT---LLRGDAQP-HSHLVLTTRFLF GLLSAERMRDIERHFGCMVSE--RVKQ-EALRWVQGQGQGCPGVAPEVTEGAKGLED--- -TEEPEEE---EEGEEPNYPLELLYCLYET-QEDAFVRQALCRFPEL------------- -----ALQRVRFCRMDVAVLS-----YC-VRCCPAGQALRLISC-RLVAAQE--KK---- ---------------------K-KSLGKRLQASLGGGS------SSQGTTKQLPASLLHP L------FQAMTDP------LCHLSSL--------------------------------- ------------------------------------------------------------ ---TL-SHCKLPDAVC--RDLSEALRAA-PAL-TELGLL-HNRLSEAGLRMLSEGLA--W -PQCRVQTVR-------------------------------------------------- -----------VQLPDPQRG-----LQYLVGMLRQSPA-LTTL----------------- --------------------------------------------DLSGCQLPAPMVTYLC AVLQHQGCGLQTL----------------------------------------------- ---------SLASVELSEQSLQELQAVKRAK-PDL------------------------- ------------------------------------------------------------ ---------------------------------------VITHPALDG-HPQPPKELIST F----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_musculus_ENSMUSP00000104024 ------------------------------------------------------------ ------------------------MMDSSGYGLLQYLQKLSDEEFQRFKEHLRKEPEK-- ----F-KLK-PISWTKIKNTSKEDL-VMQLYTHYP--GKAWDMVLSLF-----LQVNRED LSTMAQTE---------------------------------------------------- ------------------------------------------------------------ ------RRDK-------------------------------------------------- ----QTKYKEFMKNTFQHIWTMETNTYIPDRSYHEFIE---VQYR--------------- -------------ALQDIF----DCESEPVT--VVVSGSRGGGKTTFLR-KAMLDWASRN LLQNRFQYVFYFSVFSLNN-ITELS--LAELISST--LPESSETVDDILSD-PKRILFIL DGFDYLKFD------L---ELRT----NLCNDWRKKLPIQIVLSSLLQKIMLPECSLLLE LGNASLSNIIPLLQYPREIIMSGFSEQTIEIYCVSFFNTQ----------TGVEIFKNLK SIKPLFNLCRCPHLCWMICSTIK-----WQYERR-EVASR--FGRTLGLLYTIFMVSAFK STYAR----------NPSKQNRARIRTLCTLAVEGMW-KQVYVFDSDDLRRNGISESD-K KVW--LRMKFLQNQGS-----NIVFYHS-TLQWYFAVLFYFL-QYKDTR--H-------- --------------------------PVIGNL--AQL--LGEIYAHK-QNQWFHTRILLF GMATEQVNSLLEPCFGCISSK--EVRQ-EIIRYIKSLSQ--------------------- -----QEC---NEK-LVVHPQNLFFCILDN-QEERFVRQLMDRFEEM------------- -----TV-DIS-DVDDMSATP-----YC-LHRAPKVKNLHLHIQ-KRVFLEIHDPEYGDL -----------ELF-KLDQKLL-AKHWTTLCTFLC----N--LHVLDLDSCHFNEKAIEV L------CNCLPLTSLVPLTGFKLHRLLCSFT-------------TN--------FGDGL LFCTFL------------------HLPHLKYMNLYGT-NLSN-DAVERLCSALKFSTCGV EELLL-GKCDISSEAC--GIIAASLINS--EV-KHLSLV-ENPLKNKGVMSLCEMLK--D -PSCVLESLM-------------------------------------------------- -----------LSYCCLTFIA----CGHLYEALLSNEH-LSLL----------------- --------------------------------------------DLGSNFLEDTGVNLLC EALKDPNCTLKEL----------------------------------------------- ---------WLPGCYLTSECCEEISAVLTCN-TNL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNNN-IQDTGVKRLCE A----------------------------------------------------------- --------------------------LCHPNCE--------------------------- -----------------------------------------------------------M QCL--GLDMCDFTSDCCE-------------------------------------DLALV LTT---CNT---------------------------------LKSLNLDWNA-FDHSGLE MLCKALN-----HKACN---LEVLG----L-DKSLFSEESQTLLQAVEKKNKNLK---VL HFPWLKEELEKRGVRLVWNSKN-------------------------------- >O_cuniculus_ENSOCUP00000002291 ------------------------------------------------------------ ----------------------MAMLDLTDLDLLWFLQTLSDKEFQSFKDCLEHDPLA-- ----L-GLT-QLPLLPLRRAGREEL-VDILTATYEA-QDTWMMAGNAF-----DKINRID LCERIRRR---------------------------------------------------- ------------------------------------------------------------ ------RRRH-------------------------------------------------- ----EEIDKVVVGRKVLYQWEQCPFAEVHNYFYGEIAI---NTLH--------------- -------------VLQFIYENSD-YSAKNLN--VFLFGEGAIGKTMVIR-MAVLGWIKEE IWKDTISYVVYLTSHEINQ-ITCCS--LVELISKD--WPGGYAPVADILAY-SKHLLFIL EDLDNINCS------LN--VDEL----ALCSDSRQQVPMSVLLASLLQRKMAPGSWFLIS SRFGGETAMRTLMKHSDYCLTLQFSDERRKLYFTLFFRNEQ---------KVMTACRLVH DNEMLISLCQVPALCWVTCTALS-----RHLGKG-DDIKL--SYQTHTDVFTHFLANTLT PEAGA----------TGGQHRLVLLERLCTLAVEGLL-HDTQNFSDEDLRSVGLTEDD-V SLV--QARKILVRCSN--IQDRHTFIHL-KVQEFCAAIAYMMILN------S-------- -----------------------------CQI--PSASRKLKEKRET-YPDFSPVTVSIF GLLNEKRRKILETSFGCQLLV--SLRQ-YFRQQMECLSN--------------------- -----NPK---A---M-EYHMPVFYCLFEN-QEEEFVKQIMGFFLQA------------- -----TV-NIR-TSRDLMVSS-----YC-LKHSQTLQRLKLGVL-FVFKHKDPN------ -----------VKL-TSRQVRN-LAYWRDICSLLH-TNEN--LRELELCNSDLHSTSERI L------CKSLTHA------SCRLQTLKLSNL-------------AV-----G--SEFDD LFRAIA------------------QIKSLTSLSLNRM-DMSP-KMFSLLHEILDSPACNL QHLCL-MKCDLKASAC--RDVASLLVDS-KKL-KKLTLS-NNPLKNDGVKILCDALL--H -PNCILESLV-------------------------------------------------- -----------LFFCCLTEAC----CSSIGRVLLLSKT-LKHL----------------- --------------------------------------------DLSVNFLQNHGVLVLT LPLMFPTCKLQEL----------------------------------------------- ---------ELSGCFFNGDVCRDIASAIVNN-QNL------------------------- ------------------------------------------------------------ ---------------------------------------RSLELGSNY-LGDAGVTLLCE A----------------------------------------------------------- --------------------------LRHPSCK--------------------------- -----------------------------------------------------------L ENI--GLEECMLTSASCE-------------------------------------SLASV LRS---SKT---------------------------------LKRLNLLGNK-LGDEGIV QLVQGLG-----EPSCV---LQTL------------------------------------ ------------------------------------------------------ >O_cuniculus_ENSOCUP00000014512 ---------------------------------------------------MSDAIP--- GPSALSSSVVYASFLPFWITSCCSAS-PYEKGLMLYLLYLSKEELRQFKQLLVRQF---- ----S-ISA-QPAGEQLEAASWAEL-AHFLTQYFPG-RQAWDVTHNLF-----AKMNQQN MCFLVQKE-----------------------------LNXXXXXXXXXXXXXXXXXXXXX ------------------------------------------------------------ ----XXXXXQ-------------------------------------------------- ----LREYKLRVLRKFFPEWDRIAWPGNRVDFFYQEVH---KHKT--------------- -------------FLPCLFLPRKPQGRPAKT--IIIDGAPGVGKTTLAR-KLMVAWARNQ FYVHKGWFVFYFQCQEV-L-ASEQS--CSELIARQ--WPGCQALVSKILSK-PDQLLLLF DGFEKLTRP------LF--VRQR----ELSADWSRKLPGAVLLSSLLNKTMLPEASVLLT MRMNSWWVVRPLLKSPFFVTLRGFTMMEKIRYLRTYFGNTE---------EGERAVDFAR RNTILFSLCRVPALCWMVGSCLR-----QQMQAG-VDLAE--ACPNATAVVALYVSSLFP FRAEP----------LPGRTHLEHLEGLCHLAALGMW-SMKWVFGKEDLEEAKVDELD-V SSF--LGADILQEVEG--EEPRYTFAFA-VFQEFLAALFHVLYFPGRPT--P-------- --------------------------FHLLGH--GDIQYLIASPGGS-RSHLAHMGMFLF GLFNVSCAAMVRRVFHCELSW--GNKR-KVLQTVSLLLE--------------------- -----GDL---PAL-C-CGVPQLFYCLTEV-REEDYVSQALSGYRKA------------- -----VL-KMQ-SNKDVQLSA-----FC-LKRCRRLQEVELTLM-VNFSQVWWPGPGDSL H----------AAE-IQESDMQ-YQWWQDICSVLT-TNEG--LALLTLTKSILEAPLVKV L------AAALRHP------QCKLQKLSLRHL-------------GP-----S--VLHED LFCVLV------------------ENRHLSCLEIQYT-EVGT-EAMRDLCAALRHPQCAL QCLRL-EYCMAAPEDW--IDLAKGLQND-IHL-GTLLLK-RNPLESFMANYVS------- -AS-RLERLS-------------------------------------------------- -----------LETCNLTGLA----CERLASSLQQSKM-LSHL----------------- --------------------------------------------SLADNPLGDEGVKPIW KALEQLACPLQRL----------------------------------------------- ---------VLRKCALTSACCQDVASVLCQS-QTL------------------------- ------------------------------------------------------------ ---------------------------------------RSLDLSFNS-LMDKGVTLLCE A----------------------------------------------------------- --------------------------LKNPDCS--------------------------- -----------------------------------------------------------L QVL--XXXXXXXXXXXXX-------------------------------------XXXXX XXX---XXX---------------------------------XXXXXXXXXX-IGLLGIL TLVGAFP-----SQRQR---DKVL------------------------------------ ------------------------------------------------------ >P_troglodytes_ENSPTRP00000019737 ------------------------------------------------------------ ----------------------M-TSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLE-- ----D-VLQ-KTPWSEVEEADGKKL-AEILVNTSSE-NWIRNATVNIL-----EEMNLTE LCKMAKAEMMEDG--QVQEIDNPELG----------DAEEDSELAKP------------- ------------------------------------------------------------ ----GEKEGW-------------------------------------------------- ----RNSM-----EKQSSVWKNTFWQGDIDNFHDAVTL----RNQ--------------- -------------RFIPFLNPRTPGKLTPYT--VVLHGPAGVGKTTLAK-KCMLDWTDCN LSP-TVRYAFYLSCKELSR-MGPCS--FAELISKD--WPELQDDIPSILAQ-AQRILFVV DGLDELKVP------PG--ALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPKAALLVT TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPVP--TCLTRTGLFLRFLCSRFP Q----------------GAQLRGALRTLSLLAAQGLW-AQMSVFHREDLERLGVQESD-L RLF--LDGDILRQDRV--SKGCYSFI---------------------------------- ------------------------------------------------NPDLIQVGHFLF GLANENRAKELEATFGCRMSP--DIKQ-ELLRCKAHLHA--------------------- -----NKS---L-S-V-TDLREVLGCLYES-QEEELAKVVVAPLKEI------------- -----SI-HLT-NTSEVRHCS-----FS-LKHCQDLQKLSLQVA-KGVFLENYMDFELDI EFE-------------------------------S-SNSN--LKFLEVKQSFLSDSSVRI L------CDHVTRS------TCHLQKVEIKNV-------------TP-----D--TAYRD FCLAFI------------------GKKTLTHLTLAGH-IEWERTMMLMLCDLLRNRKCNL QYLR-------------------------------------------------------- ------------------------------------------------------------ -----------LENCRLTEAS----CKDLAAVLVVSKK-LTHL----------------- --------------------------------------------CLAKNPIGDTGVKFLC EGSSYPDCKLQTL----------------------------------------------- ---------V-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LWSCSLMPFYCQ-------------------------------------HLGSA LLS---NQK---------------------------------LETLDLGQNH-LWKSGII KLFGVLR-----QRTGS---LKTLR----L-KTYETNLEVKKLLEEVKEKNPKLT---ID CNASGAT--APPCCDFFC------------------------------------ >O_cuniculus_ENSOCUP00000004989 --------------------------------------STDPISSKLPKNL--------- ------LSDQNLSSQPCVTKEDDQWVSFSNYGLQWCLKELSKEELQTFKELLRKKHSR-- ----S-TTS-ALPWTEVDNTNTESL-ASLLHEYYER-PTAWTMAIDIF-----EEMKLLT LSEKARDE-----------------------------MKKHSTDTVPEDAAPVRTDQGPS KEEAPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX X---XXDDTD-------------------------------------------------- ----RRDYKAHVKSKFAIKSDSHNGSENAASDW--------PEMQ--------------- -------------MLADIFNPDQR-GFRPRT--VVLHGRSGVGKSALAR-RVILRWAEGA LYQDLFNYVFFLHASDIKW-REESS--FVELLARE--WPHPQFPATEILSR-PGRLLFIL DSFDDLDSA------PG--LCAG----KLCTDWTERRPRCALVRSLLKKALLPESSLLVT VRDVGMEQLKSLIVSPLYLVVGGIPVQRRI---LEHIPGKH---------RKMQVLHSVV DNHRLFDQCQVPAVCLLICSALE-----LQEAVG-KSLAP--TCQTL-GLYATFVFHQPT PGAALQ--------RCLSQEERAVLKGLCHVAVQGVW-SRKSVFSSDDLRAHGLRASE-L SSM--FPMSLLLQGVH--GERRYAFVHL-SLQDFFAALYCV-EALEKET--S-------- --------------------------SCSLFF--EAAQSWLELKQTGIDSRLARVKHFLF GLMSREVMRTLEIRLGCPVPQ-GVVKR-ELLHWVSLLGR--------------------- -----QAT---ASA-P-ADVIESFHCLFET-QDEDFVLEALDSFQDV------------- -----RL-PIS-QRMDLIASS-----FC-LRHCRHLRRIRVDVK-DLFLKDEFA-VWP-T I----------PPW-MQTRTLM-DECWENFCSVLA-THPS--LRQLDLGSSILSDWAMKV L------CAKLRHP------ACRIQTLXXXXX-------------XX-----X--XXXXX XXXXXX------------------XXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXX XXXXX-XXXXXXXXXX--XXXXXXXXXX-XXX-XXXXXX-XXXXXXXXXXXXXXXXX--X -XXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXX-XXXXXXLTQCNLDVAG----CGYLAFALKDNRR-LTHL----------------- --------------------------------------------SLNKNPLGDSGVKLLY EVMREPSCHLQDL----------------------------------------------- ---------EVADCRLTAACCGSLSHVIVRS-KHL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLAGNA-LGDTGMAALCE G----------------------------------------------------------- --------------------------LKQRTSV--------------------------- -----------------------------------------------------------L QRL--GLEACGLTSDCCG-------------------------------------ALLLA LSH---NQH---------------------------------LTSLNLVRNN-FSPNTVK KLCSAFA-----RPTSN---LRII------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000033281 ------------------------------------------------------------ ----------------------MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEK-- ----F-ELK-PIPWAELKKASKEDV-AKLLDKHYPG-KQAWEVTLHLF-----LQIDRKD LWTKAQEE-----------------------------MR--------------------- ------------------------------------------------------------ --------NK-------------------------------------------------- ----LNPYRKHMKEKFQLIWEKETCLPVPEHFYKETMK---NKYK--------------- -------------ELNGAY----TAAARLHT--VVLEGSDGIGKTTLLR-KVMLDWAEGN LWKDRFTFVFFLNVYEMNG-VTETS--LLELLSRD--WPESSETIEDIFSQ-PEGILFIM DGFEHLKFN------L---KFKA----DLSDDWRRQQPTSIILSSLLQKKMLPECSLLIA LGKLAMQKHYFMLQHPKLIKLSGFTESEKKSYISYYFGEKN---------KALKVFNFVR DSGPLFILCHNPFICWLVCTCMK-----RRLERG-EDLEI--SSQNTTSLYASFLTNVFK AGSQS----------FVPKVNRARLKNLCALAAEGVW-TYTFVFCHEDLRRNGLSESE-G LMW--VDMRLLQRRG-----DCFTFIHL-CIQEFCAAMFYLLKRPKDNP--N-------- --------------------------SAIGSI--TQL--VKATVIQP-QTHLTQVGIFMF GISAEEIVSMLETSFGFPLSK--DLQQ-EITQSLKSLSQ--------------------- -----CEA---DRE-A-IGFQELFVSLFET-QEKEFVTQVMNFFEEV------------- -----FI-YIG-NIEHLVIAS-----FC-LKHCRGLTTLRMCME-NIFPDDSGCASGCFT GESRS------LFS-RSYN-EK-LVYWRELCSVFI-TNKD--FQILDMENSSLDNASLAI L------CKALTQP------ACKLRKLIFTSM-------------LN-----F--GHDSE LFKAVL------------------HNPHLKLLSLYGT-SLSH-TDVRHLCETLKHPMCKI EELM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000031445 ------------------------------------------------------------ ----------------------M-TSPQLEWTLQTLLEQLNEDELKSFKSLLRALPLE-- ----D-VLQ-KAPWSEVEEADGKKL-AEILIHTSSE-NWIRSATVTVL-----EEMNLTE LCKMAKSEMLEAG--QVQEIDNPQLG----------DAEEDSELAKP------------- ------------------------------------------------------------ ----GEKEGR-------------------------------------------------- ----RNSV-----QKQSLVWKNTFWQGDIDSFHDDVIQ----RNQ--------------- -------------RFIPFLNPRTPRKLTPYT--VVLHGPAGVGKTTLAK-KCMLDWTDCN LSP-TVRYAFYLSCKELSR-MGPCS--FAELISKD--WPELQDDIPHILAQ-AQRILFVV DGLDELKVP------PG--ALIQ----DICGDWEQQKPVPVLLGSLLKRKMLPKATLLVT TRPRALRDLQLLVQQPIYIRVEGFLEEDRRAYFLRHFGDED---------QAMRAFELMR SNAALFQLGSAPAVCWIVCTTLK-----LQMEKG-EDPAP--TCLTSTGLFLRFLCSQFP Q----------------GAQLRGALRALSLLAAQGLW-AQMSVLHGEDLESAGVQESD-L RPF--LDRDILRQDGV--AKGCYSFIHL-SFQQFLTALFYALEKEEEED--R-------- ---------DG-------------HAWDIGDV--QKL--LSEEERLK-NPDLIQVGHFLF GLANEKRVKELEATFGCQMSP--EIKQ-ELLRCKASLHA--------------------- -----NKP---L-S-M-TDLKEVLCCLYES-QEEELAKVVVAPLKKI------------- -----SI-NLT-NTSEMMHCS-----FS-LKHCRDLEKVSLQIA-KGVFLENYVDFEPDI EFE-------------------------------S-SNSN--LKFLEVKQSFLSDSSVRI L------CDHITRS------TCHLQKVEIKNV-------------TP-----D--TAYRD FCLAFI------------------GKRTLTHLTLEGH-IEWERTMLLLLCDLLRNHKCNL QYLRL-GGHCATSEQW--VDFFYVLKAN-QSL-RHLHLS-ASVLLDEGAKLLYKTMT--H -PKHFLQMLS-------------------------------------------------- -----------L--CPVTAPGGPLHLGLLAFLVFCGRD-DLHR----------------- --------------------------------------------TEGRGCVSDTFCKFAC FLCTSPPASRQLK----------------------------------------------- ---------VLQQCSITKRGCRYLSEALQEA-CSL------------------------- ------------------------------------------------------------ ---------------------------------------TNLDLSLNQ-IA-RGLWILCQ A----------------------------------------------------------- --------------------------LENPNCN--------------------------- -----------------------------------------------------------L KHL--RLWSCSLMPFYCQ-------------------------------------HLGSA LIS---NQK---------------------------------LETLDLGQNH-LWKSGII QLFRVLR-----QRTGS---LKTLR----------------------------------- ------------------------------------------------------ >R_norvegicus_ENSRNOP00000029443 ------------------------------------------------------------ ------------------------MVDTSGYGLLKHLRKLSDGEFWSFKELLRKEPEK-- ----F-KLK-PISWMKIENASKEEL-VMLLNTHYP--KQAWDMALSLF-----LQVNRED LSIMAQKK---------------------------------------------------- ------------------------------------------------------------ ------RRYK-------------------------------------------------- ----QTKYKKFMKTTFQSIWTLESNICIPDRSYHLIVE---HQYR--------------- -------------KLQNIF----DSESEPVT--AVVTGPTGEGKTVFLR-KAMLDWASGI LWQNRFQYVFFFSVLSLNN-TTELS--LAELISSK--LPESSETLNDILSD-PKKILFIL DGFDYLKFD------L---ELRT----NLCNDWRKILPTQIILSSLLQKIMLPESSLLLE LGHISLPKIFPLLQYPRDITIQGFSERCLKTYFISFFNTE----------KGIEVFENLK SNQ-MLKLCSNPYLCWMFCSCLK-----WQFDRE-EEAYF--QAKTDSVFFTSFMVSAFK SAYAS----------NPPKQNRAQLKSLCTLAVEGMW-KQLFVFDSEDLRRNGISESD-K AVW--LRMKFLQNHDN-----HIVFYHP-TLQLYFASMFYFLKQDKDTH--V-------- --------------------------PVIGSI--PQL--LRKIYARD-HTQWLQIGIFLF GLATEQVASLLKPYFGFIQHR--DVRQ-EVMRYLKSLSQ--------------------- -----REC---CEK-L-ERPQNLFACLRDN-KEEKFVREVVDLFEEI------------- -----TV-DIT-NSHVLSIIA-----NH-LQKSSKLKKLHLHIQ-KRVFLEIHDPEYSDS -----------ETF-TQDKKNA-AEYWKKLCHIFV----N--LHVLDLDSCNFNKQVIEE L------CNVLSPSPKIPLMAFKLESLLCSFM-------------TN--------FGDGS LFHTLL------------------QLPHLKYLNLYGT-NLSN-SRIENLCSALRRSTCKV EELLL-GKCDISSEAC--GIIATSLMNS--KV-KHLSLV-ENPLKNKGVMSLCEMLK--D -PSCVLETLM-------------------------------------------------- -----------LSYCCLTFIA----CGHLYEALVSNKH-LSLL----------------- --------------------------------------------DLGSNFLEDTGVNLLC EALKDPNCILKEL----------------------------------------------- ---------WLSGCFLTSECCEEISAVLTCN-NNL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNND-IEDTGVKHLCE A----------------------------------------------------------- --------------------------LSHPNCK--------------------------- -----------------------------------------------------------L ECL--GLDLCKFTSDCCE-------------------------------------DLASA LTT---CKT---------------------------------LNSLNLDWKT-LEHSGVV ALCEALN-----HKKCN---LKMLG----L-DKSAFSVESQTLLQAVEKKNNNLS---IL HYPWVEEERKKRGVRLVWNSKN-------------------------------- >P_troglodytes_ENSPTRP00000005475 ------------------------------------------------------------ -----------MDQPEAPCSSTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPD-- ------GR--SIPWGRLERADAVDL-AEQLAQFYGP-EPALEVARKTL-----KRADARD VAAQLQEQRLQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------VLQL-ARVKERNAR---SVKITKRFTKLLIAPES-AAPEEEALGPAE-- EPEPGRARRSDTHTFNRLF-RRDEEGRRPLT--VVLQGPAGIGKTMAAK-KILYDWAAGK LYQGQVDFAFFLPCGELLERPGTRS--LADLILDQ--CPDRGAPVPQMLAQ-PQRLLFIL DGADELP-A------LG--GPEA----APCTDPFEAASGARVLGGLLSKALLPTALLLVT TRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDER---------RAERAYRFVK ENETLFALCFVPFVCWIVCTVLR-----QQLELG-RDLSR--TSKTTTSVYLLFITSVLS SAPVA-----------DGPRLQGDLRNLCRLAREGVL-GRRAQFAEKELEQLELRGSKVQ TLF--LSKKELPGVLE--TEVTYQFIDQ-SFQEFLAALSYLLEDGGVPR----------- --------------------------TAAGGV--GT---LLRGDTQP-HSHLVLTTRFLF GLLSAERMRDIQRHFGCMVSE--RVKQ-EALRWVQGQGQGCPGVAPEVTEGAKGLED--- -TEEPEEE---EEGEEPNYPLELLYCLYET-QEDAFVRQALCGLPEL------------- -----ALQRVRFCRMDVAVLS-----YC-VRCCPAGQALRLISC-RLVAAQE--KK---- ---------------------K-KSLGKRLQASLGGSS------SSRGTTKQLPASLLHP L------FQAMTDP------LCHLSSL--------------------------------- ------------------------------------------------------------ ---TL-SHCKLPDAVC--RDLSEALRAA-PAL-TELGLL-HNRLSEAGLRMLSEGLA--W -PQCRVQTVR-------------------------------------------------- -----------VQLPDPQRG-----LQYLVSVLRQSPA-LTTL----------------- --------------------------------------------DLSGCQLPAPMVTYLC AVLQHQGCGLQTL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ITHPALDG-HPQPPKELIST F----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >P_pygmaeus_ENSPPYP00000003320 ------------------------------------------------------------ -----------MDQPEAPCSGTGPRLAVARELLLAALEELSQEQLKRFRHKLRDVGPD-- ------GR--SIPWGRLERADAVDL-AEQLAQFYGP-EPALEVARKTL-----KRADARD VAAQLQEQRLQRLGLGSGAL---------------------------------------- ------------------------------------------------------------ ----LSVSEY-------------------------------------------------- ----KKKYREHFLQLHARVKERNAR---SYSITKRFTKLLIAPES-A------------- ------------------------------------------------------------ --------------GELLERPGTRS--LADLILDQ--CPDRGAPVPQMLAQ-PQRLLFIL DGADELP-A------LG--GPEA----APCTDPFEAASGARVLGGLLSKALLPTALLLVT TRAAAPGRLQGRLCSPQCAEVRGFSDRDKKKYFYKFFRDER---------RAERAYRFVK ENETLFALCFVPFVCWIVCTVLR-----QQLELG-QDLSR--TSKTTTSVYLLFIASVLS SAPVA-----------DAPRVQGDLRNLCRLAREGVL-GRRAQFAEKELEQLELRGSKVQ TLF--LSKKELPGVLE--TEVTYQFIDQ-SFQEFLAALSYLLEDGGVPR----------- --------------------------TAAGGV--GT---LLRGDAQP-HSHLVLTTRFLF GLLSAERMHDIERHFGCMVSE--RVKQ-EALRWVQGQGQGCPGATPEVTEGAKGLED--- -TEEPEEE---EEGEEPNYPLELLYCLYET-QEDAFVRQALCRLPQL------------- -----ALQRVPFCRMDVAVLS-----YC-VRCCPAGQALRLISC-RLVAAQE--KK---- ---------------------K-KSLGKRLQASLGGSS------SSRGTTKQLPASLLHP L------FQAMTDP------LCHLSSL--------------------------------- ------------------------------------------------------------ ---TL-SHCKVPDAVC--RDLSEALRAA-PAL-TELGLL-HNRLSEAGLRMLSEGLA--W -PQCRVQTVR-------------------------------------------------- -----------VQLPNPQRG-----LQYLVGMLRQSPA-LTTL----------------- --------------------------------------------DLSGCQLPSPMVTYLC AALQHQGCGLQTL----------------------------------------------- ---------SLASVELSEQSLQELQAVKRAK-PDL------------------------- ------------------------------------------------------------ ---------------------------------------VITHPALDS-HPEPPKELIST F----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000012994 ---------------------------------------------------MSDVNPPSD TPIPFSSSSTHSSCNPPWTFSCYPGS-PCENGVMLYMRYVSNKELQWFKQFLLNEL-R-- ----A-GTT-PITWDQVKRASWAEV-VHLLIERFPG-RRAWDVTSKIF-----AVMNCDK MCALVHRE-----------------------------INAILPTLEPEDLNVGETEVNLE ------------------------------------------------------------ ----EGESGK-------------------------------------------------- ----IQQYKLNVIVKCFPTWDFMTWPGNQRDFFYQDVH---RHME--------------- -------------YLPCLLLPKRPRGRQPKT--VVIQGVPGIGKTTLAK-TVMLEWASNR FYAHKPWCAFYFHCQEMNQ-TTEHS--FSELIEHK--WPGSQDLVAKIMSK-PDQLLLLL DGFEELTST------LI--NRPE----DLSEDWRQKLPGSVLLSSLLSKRMLPEATLLIM IRCTSWPTCKPLLKRPSLVTLPGFNTTEKIKYFQMYFGYGE---------T-DRVLSFAM ENTILFSMCQVPVVCWMVCSGLK-----QQMERG-NNLTQ--ACPNATSVFVRYISSLFP TRAEN----------FSRKIHQAQLEGLCHLAADGMW-HRQWVFGKEDLEEAKLDQMG-V AAF--LGMSVLRRIAD--Q--------------------------------N-------- --------------------------FHVLSH--MNIQRLIASPRGS-KSYLSHMGLFLF GFLNGTCALAVEQSFRCKVSF--NNKR-KLLKVIPLLQK--------------------- -----CEP---PSP-C-SGVPQLFYCLHEI-REEAFVSQALNGYHKA------------- -----VL-KIG-NSKDVQVSA-----FC-LKRCEHLQEVELTVT-LNLKNVWKLSSG-SR P----------GSE-APESKEL-HCWWQDLCSVFA-TNDK--LEVLTLTNSALGPPFLKA L------AAALKHP------QCKLQKLLLRRV-------------NS-----T--MLNQD LIGVLM------------------GNEHLRYLEIQHV-EVES-NVVKLLCKALRSPRCRL QCLRL-EDCLATPRIW--TDLGSNLQVN-RHL-KTLILT-KNSLENCGACYLS------- -VA-QLERLS-------------------------------------------------- -----------IENCNLTQLS----CESLASCLRKSKM-LTHL----------------- --------------------------------------------SLAENALKDEGVKHIW NALSHLRCPLQRL----------------------------------------------- ---------VLRKCDLTFNCCQDMISALCKN-KTL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLSFNS-LKDDGVILLCE A----------------------------------------------------------- --------------------------LKNPDCT--------------------------- -----------------------------------------------------------L QIL--E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >R_norvegicus_ENSRNOP00000030734 MGTQSPTTPPKKDDKAIPKDEGSEKEQTSESKITPEKSDKASPKDKGSEEEQTSESKITP PRKDDKAIPKGERSEEEQTSPESKITPEKSDKASPKDKGSEEEQTSESKITPPRKDDKAI PKEERSEEEQTSSESTTTPPKKDDK-AIPKKEGSEEEQISPESPTTPP-----KKDDKAI LKDEGSEE-EQ--------------------------ISESTTTPPEKDDEAIPKDEGSE EEQISEALQAKEQDAMTKSSYLT------------------------------------- ----SYRGGD-------------------------------------------------- ----LQDYKAHVIAKFDTSVDLHCDG---------------PEMK--------------- -------------VLSDAFKPHQK-TFRPHT--IILHGRPGVGKSALAR-SIILGWAQGK LYQD-MSYVFLFSVREMKW-TEKSS--LAQLMANE--WPHSQAPVTKIMSQ-PERLLFVI DGLDDMDSA------LQ--HDDM----TLSRDWKDKQPIYILVYSLLRKALLSQSFLIIT TRNTGLENLRSMVVSPLYILVEGLSASRRSQLVLENIPDDH---------QKIQVFHSVI ENHQLFDQSQAPSFCSLVCEALQ-----LQEKLG-KRCTL--PCQTLTDLYATLVFHQLT SRGPSQ--------RALSKEEQITLVGLCRMALEGVW-TMRSVFYDDDLKSYSLKQSE-I SAL--FHVNILLQVGHS-SEQCYVFFDL-SLQDFFAALYYVLEGLGEWN----------- --------------------------QYFSYI--TNQRNIMEVKRSS-DSHLLEMKRFLF GLMNKDTLKTVEVLFRCPVTP--PIKQ-KLQHCLSLIGQ--------------------- -----QVN---GSS-P-MDTLDAFYYLFES-QDEEFVHMALKSFQEV------------- -----WL-LIN-QKMDLMVSS-----YC-LQQCQNLKAIRVDIS-DLFSVDNTPKLCP-V A----------LQK-TQCKPLI-IEWWENFCTVLS-THPN--LKTLDLGHSILNEWSMKI L------CLKLRNS------SCSIQNLTFKNS-------------EV-----V--SGLQY LWMLLV------------------SNRNLKYLNLGNT-PMKD-DDIKLACEALKHPSCSL ETLRL-DSCELTLTGY--ELISKLLLSA-SSL-KCLSLA-RNKVGVKSMTSLGEALS--S -STCTLQKLILSLCGG---ALAPSLCLSSYLLPTRTHTHTHMHQEEVLSLSISVLCSILG NPVCLCLHR--LNHCNIIKDA----YGFLALILANNRK-LTHL----------------- --------------------------------------------SLTMNPVGNSAMKLLC EALKEPTCYLQDL----------------------------------------------- ---------ELVDCQLTENCCEDLACMITTT-KHL------------------------- ------------------------------------------------------------ ---------------------------------------QSLDLGNNA-LGDKGVITLCK G----------------------------------------------------------- --------------------------LKQSSSS--------------------------- -----------------------------------------------------------L RRL--GLAACGLTSKCCE-------------------------------------VLSSA LSC---NPY---------------------------------LNSLNLVRND-FNTSGML KLCSAFQ-----NPASN---LWIIG----L-WKQQFYAQVRRQLEEVQFIKPHVV---ID GDWYSIDEDDRNWWKN-------------------------------------- >M_musculus_ENSMUSP00000045077 ------------------------------------------------------------ ----------------------MEHFDPLGFNLKDVLRKLDKTELNNFKRTLRSCSLP-- ----D-TMK-QINKLTMDLANGAQL-AEILTDHCPS-AWIKRVTVQIL-----EEINRVD LAELVVKQIEEAVLKVPEEKVSSKPREPSGTLTFPWNFVQGAKRP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----EDKQKEEWKTRYTAKWKQNFWPKCNKEIY-VVTE----SYK--------------- -------------TLLALCNPKIE-TPFAHA--IVLHGPPGSGKTTMAK-QLMLEWSESK QAQ-IFSCAFYISCREVNN-TKPCT--FAHLLSMD--NPSWRDCVIRDLIL-GKEFLFVV DGFDELTFP------AG--ALIR----DLCGDWNTVKPVEVLLGSLLKRKMAPHATLLVT TRTQSLHQIFVMMDQPLLVETLGFLEQEKQEYFQKYFEDEEGEEEDKGEGKALRALKEVR CNADLYQMASLPTACGIFCLCLE-----LRMKKG-EDLSL--TCQTYTSMFLNFLCEVFS SETCE---------DHLNEEFQILFKKICILAANSLL-EQVPILCEEDFLTLKLNLNN-L HPM--VCRHILFKDSS--STHCLSFICL-GIQQLLAAIIFVQELGQESK--G-------- --------------------------VSKYSI--QNM--LSREARLK-NPDLSGLLPFVF GLLNETRIQELKTTFGCQIST--EVKR-KFLECES--GE--------------------- -----NKP---LLL-L-MNMQEILSCLYES-QEEGFVKEAMVLFEDI------------- -----SL-HLK-TSTDLIHAS-----FC-LKNSQNLQTMSLKVE-KAVFPENVAALESTA K----------HQR-SPDEQRM-LTFWTDFCDTFN-SNKK--LVFLDIHESFLNSSALEI L------CEKLPSA------SCCLQKVVLKNI-------------SP-----D--DAYEK LCLIFN------------------GYKTISHLILQGG-NLDS--MHHSLCEVLKNPACNL KFLSL-GSCSTAAQKW--DDFFPVLKVN-QSL-IFLDLT-DNSLLDKSAKLLCNIWK--E -PKCILQRVS-------------------------------------------------- -----------LENCQLTEAC----CKDLSSVLMVSRT-LTHL----------------- --------------------------------------------SLANNKLGDNGVKNLC ESISCTECNLQTL----------------------------------------------- ---------VLWSCNITNAGCHYLSKMLKQT-LSL------------------------- ------------------------------------------------------------ ---------------------------------------KHLDLGLNR-IGTKGAKFLCE A----------------------------------------------------------- --------------------------LKNPKSK--------------------------- -----------------------------------------------------------L KSL--WLCGCSITPLNCQ-------------------------------------DFSET LRS---NKS---------------------------------LNTLDLSQNV-LGTDAIK TFCEALK-----LQICP---LQMLR----L-KFDEAKPSIQNLIQEMKVSHPQLR---IS SDQVDLKNPPLPHFIF-------------------------------------- >M_musculus_ENSMUSP00000083450 ------------------------------------------------------------ -----------------------MASFFSDVGLMWYLEELNRKEFIKFKEFLKQEILQ-- ----L-GLK-QISWTEVKKASRKDL-DNLQLKHYGE-KQTWDMTFNIF-----QKLNKKE LIEGAERE-----------------------------IA--------------------- ------------------------------------------------------------ --------GH-------------------------------------------------- ----PKLYRAHLKTKVTHYGFRAFNISIQDFFRKEFTK---DDFD--------------- -------------YFEDLF-LSKRTEMKPHVREVFLYGVAGIGKTLLLK-KFMFAWLEGL VIQDKFSYIFYFCCQDLKQ-LKTAS--LADLISSE--CPNPSAPIEEILSQ-PEKLLFII DSLEWIECD------LS--EQES----ELCDNCMEKKPVNIQISSLLRGKILPQSSLLIS ATPR-FEKMQDMIECTDVKIIKGFKESNINMYFHIMIRDNN---------KVHEAF-LVR ENEQLFTICQAPVLCWMVITCLK-----NEIEKG-RDPVS--ICQSTTSLYTTHIFNLFI PQSAQ----------YPSKESQAQLQSLCSLATEGMW-TGTFMFSEEALRRNGTMDSD-I PTL--LDIGM---------------------------------SHDGHP--S-------- --------------------------QHVKCI--ETL--MFMFLKKV-KVQWVFWG-FIF GLLHRALEEKLEIFFGYSLSK--KIKD-KLCQCLKTISR--------------------- -----NKS---LQE-E-IDGMK-FFCLFEL-DDEAFLVQAMNCMEQI------------- -----RF-VTK-DYSDIIIAA-----YC-LKHCSKLKKLSFSTE-NVLIEELDQSYME-- --------------------KV-LDCWNHMCSGFT-RSKD--IKVLQIKDTHFKEQVFQV L------FESLRYP------SFTLKELMVNNV-------------TF--------YDGEH MFFELI------------------QNCSLECLNLLSS-LLSP-SDVELLCKILIQSECKM EK--V-AHCKLSPDDC--KSFAFVLMRS-KSL-KDLNLA-CNNL-GQGISSLCKALC--H -QDCILKYLV-------------------------------------------------- -----------LNNCSLSEQC----WDYLSDVLSQNKT-LRHL----------------- --------------------------------------------EISVNDLKDEGLKILC KALT----VLESL----------------------------------------------- ---------SMVHCFITSSGCQDLAEVLRKK-QKL------------------------- ------------------------------------------------------------ ---------------------------------------KCLDVSNNK-LEDSGVKLLCE A----------------------------------------------------------- --------------------------MEHPNCH--------------------------- -----------------------------------------------------------L EDL--GLDDCDITGASSE-------------------------------------NLSSA FIQ---CKA---------------------------------LKNINLNGNV-FEVSEM- VFSDMLK-----QQKHS---RLIFG----L-RITDFDNESPAFLVFEEKKN--------- ------------------------------------------------------ >M_musculus_ENSMUSP00000083106 ------------------------------------------------------------ ------------------------MVDSSSYGLLQYFQKLSDEEFQRFKELLQKEQEK-- ----F-KLK-PLSWTKIKNTSKEDL-VTQLYTHYP--RQVWDMVLNLF-----LQVNRKD LSTMAQIE---------------------------------------------------- ------------------------------------------------------------ ------RRDK-------------------------------------------------- ----QNKYKEFMKNLFQYIWTSETNTYMPDRSYNTIID---RQYK--------------- -------------ALLDIF----DSESDPAT--AVVLGTRGKGKTVFLR-KAMLDWASGV LLQNRFQYVFFFSVFSLNN-TTELS--LAELISSK--LPECSETLDDILSN-PKRILFVL DGFDYLKFD------L---ELRT----NLCNDWRKRLPTQNVLSSLLQKIMLPECSLLLE LGESSCSKIIPLLQNPREIIMSGLSEQSIYFYCVSFFKIQ----------LGVEVFKDLK KNEPLFTLCSNPSMLWMICSSLM-----WGHYSR-EEVIS--SSESTSAIHTIFIMSAFK SIFGL----------GSSKYKRFKLKTLCTLAVEGMW-KQVYVFDSEDLRRNKISESD-K TVW--LKMKFLQIQGN-----NIMFYHS-TLQWYFATLFYFLKQDKDTY--H-------- --------------------------PVIGSL--PQL--LGEIYAHK-QNQWTHAQTFFF GIATKHVITLLKPCFGNISFK--TIRQ-EIIRYLKSLSQ--------------------- -----PEC---NEK-L-VHPKKLFFCLIEN-QEERFVSQVMNLFEEI------------- -----TV-DIS-DSDDLGAAE-----YS-LLRASKLKNLHLHIQ-KKVFSEIHDPEYGSL -----------ENF-KLDQKFS-AINWTMLSILFC----N--LHVLDLGSCHFNKKVIEV L------CNSLSPTPNMPLTVFKLQRLLCSFM-------------TN--------FGDGS LFCTFL------------------QIPQLKYLNLYGT-DLSN-DVVEMLCSALKCSTCRV EELLL-GKCDISSEAC--GIMATFLINS--KV-KHLSLV-ENPLKNKGVMFLCKMLK--D -PSCVLESLM-------------------------------------------------- -----------LSYCCLTFIA----CGHLYEALLSNKH-LSLL----------------- --------------------------------------------DLGSNFLEDIGVNLLC EALKYPNCTLKEL----------------------------------------------- ---------WLPGCYLTSECCEEISAVLTCN-KNL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNNN-IQDTGVKRLCE A----------------------------------------------------------- --------------------------LCHPKCK--------------------------- -----------------------------------------------------------V QCL--GLDMCELSNDCCE-------------------------------------DLALA LIT---CNT---------------------------------LKSLNLDWNA-LHHSGLV MLCEALN-----HKKCK---LNMLG----L-DKSSFSEESQTFLQAVEKKNNNLN---VL HFPWVEDELKKRGVRLVWNSKN-------------------------------- >P_pygmaeus_ENSPPYP00000011692 ------------------------------------------------------------ ----------------------MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILD-- ----F-KLP-QVPLIQL---TKEEL-ANVLPISYEG-QYIWNMLFSIF-----LMMRKED LCRKIIGR---------------------------------------------------- ------------------------------------------------------------ ------RNRN-------------------------------------------------- ----QEACKAVLRRKFILQWERHTFGKFHYKFFCDITS---DVFY--------------- -------------ILQLAYDSTSCYSANDLN--VFLMGDRASGKTMVVN-LAVLRWINGE IWQNMISYVVHLTSQEINQ-MTDSS--LAELIAKD--WPDRQAPIADILSD-PKKLLFIL EDLDNIRFE------LN--VNDS----ALCSNSTQKVPIPILLVSLLKRKMAPGCWFLIS SRPTRGNNIKMFLKEADCYTTLQLSNEKREIYFNSFFKDRQ---------RASAALRHVH EDEILVGLCRVTILCWITCTVLN-----RQMDKG-RDFQL--CCQTPTDLHAHFLADALT SEAGL----------TANQYHLGLLKRLCLLAAGGLF-LSTLNFSGEDLRCVGFTEAD-V SVL--QAANILLPSST--HKDRYKFIHL-NVQEFCAAIAFLMAVP------N-------- -----------------------------CLI--PSGSRAYKEKREQ-YSDFNQVFTFIF GLLNANRRKILETSFGCQLPMVDSFKW-YSVGYMKLSGP--------------------- -----DRE---K---L-RHHMPLFYCLYEN-REEEFVKKIVDALEEV------------- -----TV-YLQ-SDKDMMVSL-----YC-LEYCCHLRTLKLSVQ-RIFQNKEPL------ -----------VRP-TASQMKS-LVYWREICSLFY-TMET--LRELHIFDNDLNDISERI L------SKALKHS------SCKLRTLKLSYV-------------ST-----A--SGFED LLKALA------------------RNRSLTYLSLNCT-SISL-NMFSLLHDILDEPTCQI SHLGL-MKCDLQASEC--EEIASLLING-GSL-RKLTLS-NNPLRSDGVNILCDALL--H -PNCTLISLV-------------------------------------------------- -----------LVLCCLTENC----CSALGRVLLFSPN-LKQL----------------- --------------------------------------------DLCVNHLKNYGVLHVT FPLIFPTCQLEEL----------------------------------------------- ---------HLSGCFFSSDICQYIAIVIATN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------RSLEIGSNS-IEDAGMQLLCG G----------------------------------------------------------- --------------------------LRHPNCM--------------------------- -----------------------------------------------------------L VNI--GLEECRLTSACCR-------------------------------------SLASV LTT---NKT---------------------------------LERLNLLQNH-LGNEGVA KLLESLI-----RPDCA---LKVVG----L-PLTGLSTETQRLLMTVKERKPSLI---FL SETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASRQPL >M_musculus_ENSMUSP00000072895 ------------------------------------------------------------ ------------------------MAGSSGYGLLKLLQKLSDEEFQRFKELLREEPEK-- ----F-KLK-PISWTKIENSSKESL-VTLLNTHYP--GQAWNMMLSLF-----LQVNRED LSIMAQKK---------------------------------------------------- ------------------------------------------------------------ ------KRHK-------------------------------------------------- ----QTKYKKFMKTTFERIWTLETNTHIPDRNYHLIVE---VQYK--------------- -------------ALQEIF----DSESEPVT--AIVAGTTGEGKTTFLR-KAMLDWASGV LLQNRFQYVFFFSVFSLNN-TTELS--LAELISST--LPESSETVDDILSD-PKRILFIL DGFDYLKFD------L---ELRT----NLCNDWRKRLPTQIVLSSLLQKIMLPGCSLLLE LGQISVPKIRHLLKYPRVITMQGFSERSVEFYCMSFFDNQ----------RGIEVAENLR NNE-VLHLCSNPYLCWMFCSCLK-----WQFDRE-EEGYF--KAKTDAAFFTNFMVSAFK STYAH----------SPSKQNRARLKTLCTLAVEGMW-KELFVFDSEDLRRNGISESD-K AVW--LKMQFLQTHGN-----HTVFYHP-TLQSYFAAMFYFLKQDKDIC--V-------- --------------------------PVIGSI--PQL--LGNMYARG-QTQWLQLGTFLF GLINEQVAALLQPCFGFIQPI--YVRQ-EIICYFKCLGQ--------------------- -----QEC---NEK-L-ERSQTLFSCLRDS-QEERFVRQVVDLLEEI------------- -----TV-DIS-SSDVLSVTA-----YA-LQKSSKLKKLHLHIQ-KTVFSEIYCPDHCKT -----------RTS-IGKRRNT-AEYWKTLCGIFC----N--LYVLDLDSCQFNKRAIQD L------CNSMSPTPTVPLTAFKLQSLSCSFM-------------AD--------FGDGS LFHTLL------------------QLPHLKYLNLYGT-YLSM-DVTEKLCAALRCSACRV EELLL-GKCGISSKAC--GIIAISLINS--KV-KHLSLV-ENPLKNKGVMSLCEMLK--D -PSCVLQSLM-------------------------------------------------- -----------LSYCCLTFIA----CGHLYEALLSNKH-LSLL----------------- --------------------------------------------DLGSNFLEDTGVNLLC EALKDPNCTLKEL----------------------------------------------- ---------WLPGCFLTSQCCEEISAVLICN-RNL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNNN-IQDTGVRQLCE A----------------------------------------------------------- --------------------------LSHPNCN--------------------------- -----------------------------------------------------------L ECL--GLDLCEFTSDCCK-------------------------------------DLALA LTT---CKT---------------------------------LNSLNLDWKT-LDHSGLV VLCEALN-----HKRCN---LKMLG----L-DKSAFSEESQTLLQDVEKKNNNLN---IL HHPWFEAERNKRGTRLVWNSRN-------------------------------- >M_musculus_ENSMUSP00000079455 ------------------------------------------------------------ -----------------------MASFFSDFGLMWYLEELNKKEFMKFKELLQQEILQ-- ----L-GLK-QISWTEVKKASREDL-ANLLLKHYEE-KKAWDMTFKIF-----QKMNRQD LMERAGRE-----------------------------IA--------------------- ------------------------------------------------------------ --------GH-------------------------------------------------- ----SKLYQVHLKKKLTHDYARKFNIKDQDSLKQKFTQ---DDCD--------------- -------------HFENLL-ISKATGKKPHM--VFLQGVAGIGKSLMLT-KLMLAWSEGM VFQNKFSYIFYFCCQDVKK-LKRAS--LAELISKE--WPNASAPIEEILSQ-PEKLLFVI DNLEVMECD------MS--EWES----ELCDDCMEKQPVNILMSSLLRRKMLPESSFLVS ATPETFEKIEDRIECTNVKMMAGFNESNIKVYFYSLFQDRN---------RTQEIFSLVR ENEQLFSVCQVPVLCWMVATCLK-----KEIE-G-RDPVS--ICRRITSLYTTYIFNLFI PQSAQ----------CPSKKSQDQLQGLCSLAAEGMW-TDTFVFGEEALRRNGIMDSD-I STL--LD---------------------------------LLKSHVDHP--S-------- --------------------------QDVKSI--EAL--IFTFLKKV-KVQWIFFGSFIF GLLHESEQKKLEPFFGHQLSQ--EIKR-QLYQCLETISG--------------------- -----NKE---LQE-Q-VDGMKLFYCLFEM-DDEAFLAQVMNCMEQI------------- -----KF-VAK-DYSDVIVAA-----HC-LQHCSTLKKLSLSTQ-NVLSEGQEHSYTE-- --------------------KL-LICWHHVCSVLT-SSKD--IHVLQVKDTNFNERAFLV L------YSHLKYP------SCILKVLEVNNV-------------TL--------LCDNR LLFELI------------------QNQRLQLLNLSLT-FLSH-NDVKLLCDVLNQAECNI EKLM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >B_taurus_ENSBTAP00000030327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PLT--MLLEGAAGVGKTTLAT-KLVLHWAEGV LFRGRFSYVFYISGHWLAK-LGDIS--FAGLLALD--WPDSQVPVEEFRAH-PERLLFVI DGAEEVTLG------SK--GSAS----RPGADWYQELPAASILVRLLKKELVPEATLLVT AGPPGGRALRGLLLRPCRVDIPGFTEGDRREYLRRFLGDPD---------VAEEAWRRMQ GSETLVRLCAAPLACWAVCAGLK-----RQLAGS-PAPAP--GAPTPTGLYAQLFCSLLA GAEPG----------LRTGSSAGQWRAFCSLAAEGLW-LAAFTFAGDALERWRLEAPF-I DGL--LRLQILRRVSD--CEHCVTFAHR-SFQEFFGALFYVLWGAQGSL--G-------- ------------------------GVPRHQEM--RRW--LNHAFADA-NPYWRQMVRFFF GLLGTDLARQLEEAVGCRMSP--GVAD-EVLDWAEELER--------------------- -----CGA---VSG-R-FDFLWLFQCLHET-QDENLARRVLNRLPVA------------- -----DL-DIQ-GCEHLRVSS-----FC-LKHCQKLRKLRLSVS-HRVLEKKRTSGLG-- -------------------TPE-MHQWEDICSVF--CSGN--LSQLDLSNSKLSTASMMR L------CLKLGNP------QCRLQKLAWKSM-------------AP-----V--EGLRK LGLLLR------------------GDRHLTHLDLSSN-SLDA-AVSRGVFRMLGHSACGL KYLWL-ESCGLSTEVC--HQLFTELGRN-SSL-SFLSLA-DNDLSHVELERLRETPG--T -ATCALKELSLEKGNL---SAAACEDLASLLTSTPRLTRLCLGLNPLGDEGVQLLCGSLT RPEC-VLQRLELWCCRLSTPS----CRHLSDALLRSRS-LTHL----------------- --------------------------------------------NLRRNSLGDGGVKLLS SALGRADCALQSL----------------------------------------------- ---------NLSHCSLTVAGCRELAHALKHN-GHL------------------------- ------------------------------------------------------------ ---------------------------------------KILDVGNND-IQDEGVKELCS V----------------------------------------------------------- --------------------------LKSPSCV--------------------------- -----------------------------------------------------------L QTL--GLEKCSLTAACCR-------------------------------------PLSSV LGS---SKS---------------------------------LENLNLLGNN-LGPDGVS RLWMPLR-----KPTCK---LRKL------------------------------------ ------------------------------------------------------ >H_sapiens_ENSP00000312350 ------------------------------------------------------------ ----------------------MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILD-- ----F-KLP-QFPLIQM---TKEEL-ANVLPISYEG-QYIWNMLFSIF-----SMMRKED LCRKIIGR---------------------------------------------------- ------------------------------------------------------------ ------RNRN-------------------------------------------------- ----QEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSS---DVFY--------------- -------------ILQLAYDSTSYYSANNLN--VFLMGERASGKTIVIN-LAVLRWIKGE MWQNMISYVVHLTAHEINQ-MTNSS--LAELIAKD--WPDGQAPIADILSD-PKKLLFIL EDLDNIRFE------LN--VNES----ALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLIS SRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQ---------RASAALQLVH EDEILVGLCRVAILCWITCTVLK-----RQMDKG-RDFQL--CCQTPTDLHAHFLADALT SEAGL----------TANQYHLGLLKRLCLLAAGGLF-LSTLNFSGEDLRCVGFTEAD-V SVL--QAANILLPSNT--HKDRYKFIHL-NVQEFCTAIAFLMAVP------N-------- -----------------------------YLI--PSGSREYKEKREQ-YSDFNQVFTFIF GLLNANRRKILETSFGYQLPMVDSFKW-YSVGYMKHLDR--------------------- -----DPE---K---L-THHMPLFYCLYEN-REEEFVKTIVDALMEV------------- -----TV-YLQ-SDKDMMVSL-----YC-LDYCCHLRTLKLSVQ-RIFQNKEPL------ -----------IRP-TASQMKS-LVYWREICSLFY-TMES--LRELHIFDNDLNGISERI L------SKALEHS------SCKLRTLKLSYV-------------ST-----A--SGFED LLKALA------------------RNRSLTYLSINCT-SISL-NMFSLLHDILHEPTCQI SHLSL-MKCDLRASEC--EEIASLLISG-GSL-RKLTLS-SNPLRSDGMNILCDALL--H -PNCTLISLV-------------------------------------------------- -----------LVFCCLTENC----CSALGRVLLFSPT-LRQL----------------- --------------------------------------------DLCVNRLKNYGVLHVT FPLLFPTCQLEEL----------------------------------------------- ---------HLSGCFFSSDICQYIAIVIATN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------RSLEIGSNK-IEDAGMQLLCG G----------------------------------------------------------- --------------------------LRHPNCM--------------------------- -----------------------------------------------------------L VNI--GLEECMLTSACCR-------------------------------------SLASV LTT---NKT---------------------------------LERLNLLQNH-LGNDGVA KLLESLI-----SPDCV---LKVVG----L-PLTGLNTQTQQLLMTVKERKPSLI---FL SETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASRQPL >M_mulatta_ENSMMUP00000010478 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MRRKITLRWENHTFGEFHYKFFCNVAS---DVFY--------------- -------------VLQLAYDSTSCYSANDLN--VFLMGDRASGKTMTIN-LAVMKWINGE MWQNMISYVVHLTSHEINQ-MTDSS--LAELIAKD--WPDGQAPIADILSD-PKKLLFIL EDVDNLRFE------LN--VNEH----ALCSNSTQKVPIPILLVSLLKRQMAPGCWFLIS SRPTREENIKMFLKTTDCYVTLQFSNEKRELYFHSFFNDRQ---------RASTALMLVH DNEILTGLCRVAILCWITCTVLN-----RQMDKG-HDPQH--CCETPTDLHAHFLADALT SKAGL----------TTNQYHLGLLRRLCLLAAGGLF-LSTLNFSGEDLRCVGFTEVD-F SVL--QAVNILLPSST--HKDRYKFIHL-NVQEFCAAIAFLMAVP------N-------- -----------------------------CLI--PSGSRGYKEKREQ-YCNFNQVFTFIF GLLNENRRKILETTFGYQLPMVESFRR-YSVEYMKHLGR--------------------- -----DQQ---K---L-THHGSLFYCLFEN-QEEEFVKKVVNTLKEV------------- -----TL-YLQ-SNKDMMVSL-----YC-LEYCCHLRTFKLSVQ-RIFEYKEPL------ -----------VRP-TASQMKS-LVYWREICSLFC-TMDT--LWELHLFDSDLNDISERI L------SKALEHS------SCKLRTLKLSYI-------------ST-----A--SGFED LLKALA------------------RNRSLIHLSLNCT-SISL-NMFSLLREILDKSTCQI RHLSL-MKCDLRASEC--GEIASLLVNG-GSL-RKLTLT-NNPLRNDGVNILCNALL--H -PNCTLTSLA-------------------------------------------------- -----------LVFCCLTEQC----CSSLGRVLLLGRT-LKQL----------------- --------------------------------------------DLCVNHLQNYGVLHVT FPLIFPTCQLEEL----------------------------------------------- ---------YLSGCFFTNDICQYIAIVIATN-ETL------------------------- ------------------------------------------------------------ ---------------------------------------RSLEIGSNS-IEDAGMQLLCG G----------------------------------------------------------- --------------------------LRHPDCM--------------------------- -----------------------------------------------------------L VNI--GLEECMLTGACCE-------------------------------------SLASV LTT---NKT---------------------------------LERLNILQNQ-LGDERVV KLLESLI-----LPECV---LQIIG----L-PLNDVSAETRRMVMTVKERKPNLI---FL SETWSVKEGREIGVIPASQPGSVIPNSNLDYMFFKFPRMSTAMRMSSTASRQPL >P_troglodytes_ENSPTRP00000019824 ------------------------------------------------------------ ----------------------MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILD-- ----F-KLP-QFPLIQM---TKEEL-ANVLPISYEG-QYIWNMLFSIF-----SMMRKED LCRKIIGR---------------------------------------------------- ------------------------------------------------------------ ------RNRN-------------------------------------------------- ----QEACKAVMRRKFMLQWESHTFGKFHYKFFRDVSS---DVFY--------------- -------------ILQLAYDSTSYYSANNLN--VFLMGERASGKTMVIN-LAVLRWIKGE MWQNMISYVVHLTSHEINQ-MTNSS--LAELIAKD--WPDGQAPIADILSD-PKKLLFIL EDLDNIRFE------LN--VNES----ALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLIS SRPTRGNNVKSFLKEVDCCTTLQLSKEKREIYFNSFFKDRQ---------RASAALQLVH EDEILVGLCRVAILCWITCTVLK-----RQMDKG-RDFQL--CCQTPTDLHAHFLADALT SEAGL----------TANQYHLGLLKRLCLLAAGGLF-LSTLNFSGEDLRCVGFTEAD-V SVL--QAANILLPSST--HKDRYKFIHL-NVQEFCTAIAFLMAVP------N-------- -----------------------------YLI--PSGSREYKEKREQ-YSDFNQVFTFIF GLLNANRRKILETSFGYQLPMVDSFKW-YSVGYMKYLDR--------------------- -----DPE---K---L-THHMPLFYCLYEN-REEEFVKTIVDALMEV------------- -----TV-YLR-SDKDMMVSL-----YC-LDYCCHLRTLKLSVQ-HIFQNKEPL------ -----------IRP-TASQMKS-LVYWREICSLFY-TMES--LWELHIFDNDLNGISERI L------SKALEHS------SCKLRTLKLSYV-------------ST-----A--SGFED LLKALA------------------RNRSLTYLSINCT-SISL-NMFSLLHDILHEPTCQI SHLSL-MKCDLRASEC--EEIASLLISG-GSL-RKLTLS-SNPLRSDGMNILCDALL--H -PNCTLISLV-------------------------------------------------- -----------LVFCCLTENC----CSALGRVLLFSPT-LRQL----------------- --------------------------------------------DLCVNRLKNYGVLHVT FPLLFPTCQLEEL----------------------------------------------- ---------HLSGCFFSSDICQYIAIVIATN-EKL------------------------- ------------------------------------------------------------ ---------------------------------------RSLEIGSNK-IEDAGMQLLCG G----------------------------------------------------------- --------------------------LRHPNCM--------------------------- -----------------------------------------------------------L VNI--GLEECMLTSACCR-------------------------------------SLASV LTT---NKT---------------------------------LERLNLLQNH-LGNDGVA KLLESLI-----SPDCV---LKVVG----L-PLTGLNTQTQQLLMTVKERKPSLT---FL SETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRMSNTASRQPL >O_cuniculus_ENSOCUP00000012880 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------K-------------------------------------------------- ----PNPYKNRMKERFRLVWIQESNLPVPESFYKDSVG---VEYS--------------- -------------TLTRAA----AEAPGPAT--VAMNGPEGCGKTTILR-KVMLEWAEGT LWRDRYTYVFFLSVDELNR-VVETS--LAELLSKD--WPESAESLEDALAH-PEKILFIM DGFEELKFD------L---NVKT----DACSDWRRRWPTPVLLSSLLQKSMLPGCSLVLG FGTRSMQSNRFLLKHPVLVGLQPFSEHHRKLYFFHFFDDTD---------EAMRAFSFVS NIPPLFVLCESPLVCWLVCTCVK-----WQLDRG-ESLCI--DPETGTSLYVSFAATAFK AGRSD-------------SLADRRGESLCSL--EGMW-TQASS-SSADIGR-GISEFD-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------EI------------- ------------------------------------------------------------ --------------------QT-IFFWRDLCSVFT-NSRK--FQVLKLDSCTLDDVSLGI I------CKALARP------GCR-RKLVCNFI--------------------YNFGKGLD FSKAIL------------------HSFHLKYLNLYGT-SLST-GAVTYLCETLRYPACNV EELVL-GKCDLPSEVS--KDLACVLICN--KL-KSLSLI-ENALGDEGANVLCEGLK--H -SKCALQTLI-------------------------------------------------- -----------VNFCCLTRVS----CDYFSQTLPNNIS-LSTL----------------- --------------------------------------------DLGSNILGDEGVATLC EALKHQNCTLAEL----------------------------------------------- ---------CLTSCYLTPACCKDIATALTCN-ESL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGNNE-IKDAGVKQLCE A----------------------------------------------------------- --------------------------LKHPKIQ--------------------------- -----------------------------------------------------------L QRL--GLEMCQLTMACVE-------------------------------------DLASA LIT---CKS---------------------------------LKGLNLDWIV-LDHDGVV KLCEALT-----HADCV---LELL------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000006150 ------------------------------------------------------------ ------------DDPRPPVSSTGLRLAVARELLLAALEELSQEQLKRFRHKLRDVGPD-- ------RR--SIPWGRLERADAVDL-AEQLAQFYGP-EPALEVARKTL-----KKADARD VAAQLKEQRLRRLGPGPAAL---------------------------------------- ------------------------------------------------------------ ----LSVSEY-------------------------------------------------- ----KKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPES-AAPEEEALGPAE-- EPEPGRARRSDTHTFNRLF-RGDEDGRRPLT--VVLQGPAGIGKTMAAK-KILYDWAAGK LYQGQVDFAFFMPCGELLERPGTRS--LADLILDQ--CPDRGAPVPQMLAQ-PQRLLFIL DGADELP-A------LE--GPEA----APCTDPFEAASGARVLGGLLSKALLPTALLLVT TRAASPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFQDER---------RAERAYRFVK ENETLFALCFVPFVCWIVCTVLR-----QQLELG-RDLSR--TSKTTTSVYLLFIASVLS SAPVA-----------DGPRVQGDLRNLCRLAREGVL-GRRAQFAEKQLEQLELRGSKVQ TLF--LSKKELPGVLE--TEVTYQFIDQ-SFQEFLAALSYLLEDEGVPR----------- --------------------------TAAGGV--GT---LLRGDAQP-HSHLVLTTRFLF GLLSAERMRDIERHFGCVVSE--RVKQ-EALRWVQGQGQGCPGVAPEVTEETKGLED--- -TEEPEEE---EEGEEPNYPLELLYCLYET-QEDAFVRQALCRLPEL------------- -----ALQGVRFCRMDVAVLS-----YC-VRCCPAGQALRLISC-RLVAAQE--KK---- ---------------------K-KSLGKRLQASLGGSS------SSQGTTKQLPASLLHP L------FQTMTDP------LCHLTSL--------------------------------- ------------------------------------------------------------ ---T-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >R_norvegicus_ENSRNOP00000040262 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------QKEGDGWSVRILTVKL---KKFDHVC LWFSILTD---------------------------------------------------- ------------------------------------------------------------ -------LNY-------------------------------------------------- ----GIDYRTIIKENFFIIWDKTSLLGESATLNCVTTH---KDQK--------------- -------------LLEHIFDVNIQTSKSPQT--VVLYGAAGIGKTTLLK-KAVLEWADGN LYQQ-FTHVFYLSGREISQ-EKEKN--FAQLISKH--WPSSEGPIEQIL----------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QVEKG-GNVEM--TCQTSTALFTYYICSLFP RIAGS----------SVTLPNETLLRSLCQAAVEGIW-TMKHVLYQQNLRKHELTRED-L SLF--LEANVLQQDTE--CENCYTFTHL-QVQEYFAALFYLLRENPEEK--D-------- --------------------------HPLEPF--ENVHLLLESNHFH-DPHLEQMKCFLF GLLNKDRVQQLEETFNLTISR--AVRE-ELLVCLEALEK--------------------- -----DDS---PLS-Q-LRIQDLLHCIYET-QDEEFITQALTYFQKI------------- -----MV-KVD-EESKLLIYS-----YC-LKHCHSLQTVRLTAR-ADLRNMLDPTAE--- -----------ICL-RSVSVVF-ISYVEDVWWTVN-SKDN--LIVCEHWCHWMYESFL-L I------SEHLSHI------VFSQMSLVFRAV-------------CF-----L--NSCYD FS-FLA------------------FNNTVTHLDLKDT-DLGD-NGVKTLCEALKYQGCKL RVLRL-ESCDLNVTHC--QNLSKALQSN-RSL-VFLNLS-TNSLSNDGVKSLCEVLE--N -PNCPLERLA-------------------------------------------------- -----------LASCGLTKVG----CEVLSSALTKTKS-LIHL----------------- --------------------------------------------DLGFNKLADSGVKLLC QTLQQPNCNLQEL----------------------------------------------- ---------E-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >T_rubripes_ENSTRUP00000000216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGKTFSVQ-KFTLDWAEGL ENQD-ISLLVLLSFRELNL-IKDEQHSLLSLLHVF--HPTLQKIRAEDLT--ACKLLLIF DGLDESRLS------LD--FKKE----QVISDVTQVSSASMLLVNLIQGNLLPSALIWIT SRPAAANQIPPSYVD-RITEIRGFTDTQKEEYFRRRFRDED---------LSKRIISHIK ASRSLHVMCLIPVFCWITATVLE-----DMLTT--EQRGE--LPKTLTDLYSHFLLVQTK RKKQKYGG--HKGPQELIESDKEVLLKLGRLAFEHLE-NGNILFYQNDLEQCGLDVSE-V SVYSGVCTKIFRRETVIFQKSVYCFVHL-SIQEFLAAVYIFFKLYDP------------- ------------------------IIPVDDFL--SRV--MMKSLESP-NGHLDLFVRFLH GLSLESNQRILGGLLNQTDNN-PETIQ-KVINNLKEMSS--------------------- -----EQI-------SPDRSINIFHCLMEM-KDHSVHQEIQELLKIY------------- -----NI-QIVLAGVMFNWLE-----FC-LKAFCTVKCPKMSII-----IFFITTFSCDS LTSGGFHTHLYSLFRFCNCNLS-EISCGSVASALKSNPSH--LRELDLSYNQLQDSGVKL L------CSGLESP------NCKLKTLRLNN--------------CSLTE-----ISCGS LASALK-----------------SNPSHLTELDLSDN-QLQD-SGVKLLCSGLESPNCKL KTLIL-CDCSLSENSC--DSLASALKSNFSHL-RELDLGLNNQLQDSGVRLLCSGLE--S -PNCKLETLR-------------------------------------------------- -----------LRDCSLSETS----CGSLASALKSNPSHLREL----------------- --------------------------------------------DLKFNQLQDSGVKLLC SGLESPNCKLETL----------------------------------------------- ---------RLWSCSLSEISCGSLASALKSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLGLNH-LQDSGVKLLCS G----------------------------------------------------------- --------------------------LESPNCK--------------------------- -----------------------------------------------------------L KTL--GLWRCSLSEISCG-------------------------------------SLASA LKS--NPSH---------------------------------LTELDLGDNQ-LQDSGVK LLCSALE-----SPNCK---LETLS----LWSCSISEISCGSLASALKSNPSHLKELDLS C----------------------------------------------------- >T_rubripes_ENSTRUP00000011348 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RV--VLTNGVAGVGKTFSVQ-KFTLDWAEGL ENQD-ISLLVLLSFRELNL-IKDEQHSLLSLLHVF--HPTLQKIRAEDLA--ACKLLLIF DGLDESRLS------LD--FNKE----QVISDVTQVSSASVLLVNLIQGNLLPSALIWIT SRPAAANQIPPSYVD-RITEIRGFTDTQKEEYFRRRFRDED---------LSKRIISHIK ASRSLHIMCLIPVFCWITATVLE-----HMLTT--EQRGE--LPKTLTDLYSHFLLVQTK RKKQKYGG--HKGPEELTESDKEVLLKLGRLAFEHLE-NGNILFYQNDLEQCGLDVSE-V SVYSGVCTEIFRRETVIFQKSVYCFVHL-SIQEFLAAVYVFHCYTSKNT----------- --------------------------AVIHSF--VKV--MMKSLESP-NGHLDLFVRFLH GLSLESNQRILGGLLNQTDNN-PETIQ-KVINNLKEMSS--------------------- -----EQI-------SPDRSINIFHCLMEM-KDHSVHQEIQEFLKSE------------- -----KNSEQELSEIQCSALA-----YL-LQM---------------------------- ------------------------------------SEEV--LDELNLKEYNTSEEGRRR LIPAVRNCRSMFYI------NKSIRNLTKDS--------------ALRVRTFQFLTSCMK FLDLLKNIQIIFDLFGVKYIYWFTNINKII-LKLSYN-QLQD-SGVKLLCSGLENPNCKL ETLGL-SSCSLSEISC--GSLASALKSNTSHL-RELNLS-QNRLQDSGVKLLCSGLE--S -PNCKLETLR-------------------------------------------------- -----------LWGCSLTEIS----CGSLASALKSNLSHLRLL----------------- --------------------------------------------DLSYNQLQDSGVKLLC SGLERPNCKLETL----------------------------------------------- ---------RLSSCSLSEISCGSLASALKSNLSHL------------------------- ------------------------------------------------------------ ---------------------------------------TELDLNENQ-LQDSGVKLLCS G----------------------------------------------------------- --------------------------LESPNCK--------------------------- -----------------------------------------------------------L ETL--RLWSCSLSEISCG-------------------------------------SLASA LKS--NPSH---------------------------------LRELDLNENQ-IQDSGVK LLSDLVKIQQFCSP--K---LRSIE----VTS---------------------------- F----------------------------------------------------- >T_nigroviridis_ENSTNIP00000008651 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HVF--HPTLQKIRAEDLT--VCKLLLIF DGLDESRLS------LD--FSNK----QVISDVTQVSSVNVLLVNLIQGNLLPSALIWIT SRPAAANQVPPSCVD-RMTEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLHIMCQIPVFCWISATVLE-----DMLTT--DQRGE--LPTTLTDLYSHFLMVQTK RKKQ----------------NKEVLLKLGQLAFEHLE-NGNIMFYPEDLERCGLDVSE-V SVFSGVCTEIFRRESVIFQKSVYCFVHL-SIQEFLAALYMFHCYTKKNKYSERRSFS--- ------------------------RLSVGDFL--RRV--MMKSLRSK-NGHLDLFVRFLH GLSLESNQRILGGLLKQTVNH-PGTTQ-KVISNLKEMNS--------------------- -----GGI-------SPDRSINTFHCLMEM-KDHSVHQDIQQFLKIN------------- ---SDQSAASAQTFVNCKYLNIVTECFV-LDPDAKGSKTWL------------------- ------------------------------------------TKHTPLLGKKKAKNTVAL C----------------------------------------------------------- -----------------------------------------QVSCFSYFYSLLKHTQIHQ EWE---------------DAFFFIEWNGPSHL-RELDLS-LNKLDGPGMKLLCSGLE--S -PNCHLETLR-------------------------------------------------- -----------LIHCGLTAIS----CSRLGSVLKSSPSHLREL----------------- --------------------------------------------DLSGNHLKDPGVELLC SGLESPNCHLETL----------------------------------------------- ---------RLTGCRLSEISCSHLVSVLKSSPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSGNN-LKDPGVELLCS G----------------------------------------------------------- --------------------------LESPNCH--------------------------- -----------------------------------------------------------L ETL--RLTDCSLSEISCS-------------------------------------HLVSA LKS--NPSH---------------------------------LRELDLSGNH-LEDPGVK PL---------------------------------------------------------- ------------------------------------------------------ >T_rubripes_ENSTRUP00000033190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LKRRCEHVTEGTHEAGSGTLLNKIYTELYITEGQSEEVDTQHEVRQLER TSKKK-IQDTPI-KCQDIFKVLSEQQRHIRV--VLTNGVAGVGKTFSVQ-KFSLDWAEGL ENQD-ISLVLPLSCRELNL-IRDQQHSLLSLLHVF--HPTLQKIRAEDLT--VWKLLFIF DGLDESRFS------LG--FNKH----QLISDVTQVSSVDVLLVNLIQANLLPSALIWIT SRPAAAYQIPPWCVD-RITEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLHIMCLIPVFCWITAIVLE-----DMMTR--DQRGE--LPQTLTDLYSHFLRVQIK RKKQKYGG--KQRPEELTEADKDLLLKLGRLAFEHLE-KGNIMFYSEDLERCGLDVSE-V SVYSGVCTEIFKRESVIFQKSVYCFVHL-SVQEFLAAVYMFHCYTRNDTAVINQFLKY-- --------SKP-------------VKSLDDFL--RRA--LMKSLESE-NGHLDLFVRFLH GLSLESNQRILGGLLDQRNSH-PETIQ-KVLNNLKEVNS--------------------- -----DEF-------SPDRSINIFHCLMEM-KDQSVHQEIQEFLNCE------------- -----ELQEVRRVDHVIKSLL-----FVCIHRILTTGGNFIT------------------ ------------------------------------SNKR--CSENDL-KGNRQIEQKLR AIDATRDSDVIDRIAENRLSGDFFQRVIAMT----------------------------- -----------------------SNPSHLRELSLSWNQSPTD-ADVKLLFSAMMHPNSRL ETLRL-WDCSLSEISC--DSLGLALRSNPSHL-RVLDLG-GNQLQDPGVKLLCGALQ--D -PLCKLETLR-------------------------------------------------- -----------LRRCSLSETC----CDSVASALKSNLSHLRVL----------------- --------------------------------------------DLSHNTLQDSGVKRLC SGLESPNCKLERL----------------------------------------------- ---------SIVNSGLTQISCGSLASALRSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSWNL-LQDSGVKLLCG F----------------------------------------------------------- --------------------------LHFPNCR--------------------------- -----------------------------------------------------------L ETL--RLWNCSLSETSCD-------------------------------------SLASA LRS--NPSH---------------------------------LRELDLSRNQ-LKDSGVK LLSDLVK----------------------------------------------------- ------------------------------------------------------ >T_rubripes_ENSTRUP00000014676 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKVTPLNKIFTELYITDGLSEDVNTQHEVMQLET TSQRNALHHNPI-KCGDIFKPLTKREKYIRV--VLMYGVAGIGKTFSVQ-KFTLDWAAGL ENQD-VNLVIPLSFRELNL-IKDGRYSLLELLWVF--HSTLQEMAAEMLA--ACKLLFIF DGLDESRLQ------MD--FNNS----RVVSDVTEESSVDLLLTNLIRGNLLPSALVWIT SRPAAGDRIPPRLVD-RVTEVRGFTDSQKEEYFRIRFSDED---------LSNRIISHVK TSRSLHIMCLVPIFCWITATVLE-----HMFST--DEREE--LPKTLTDMFSYFLLVQIN KKKQKYGGEYEASPQELTESDRGHLLKLGQLAFEHLE-NGNIVFYQEDLEQCGLDAKE-V LVYSGVCTEIFKRESVIFQKSVYCFVHL-SIQEFLAAVYMFQCFTSRNTQVLDNFLNTH- ------------------------VPDLNTFL--TEA--IMKSFESK-NGHLDLFVRFLH GLSLEANQRILGGLLGPTDNS-SEVIS-NAIANLKQMKS--------------------- -----VDI-------PPERSINIFHCLMEM-NDQSIHQDIQEFLKSQ------------- -----NKSETKLTEVHCSALA-----YM-LQM---------------------------- ------------------------------------SEKV--LEELNPEKYNTSM----- ------------------------------------------------------------ -----------------------------------------G-GRQRLVPAVR-----NC RKAKL-SNSRLSDVHC--EVVASALRSNPSHL-RELEMS-VNKLQDSGVKLLCAGLE--S -LNCRLETLE-------------------------------------------------- -----------LRNCSLSRLS----CASLASALRSNPSHLREL----------------- --------------------------------------------KLSENELEDSGVELLC DYLANPQCRLETL----------------------------------------------- ---------RLSCCRLSQVSCAALTSVLMSNPSHL------------------------- ------------------------------------------------------------ ----------------------------------------ELELSYNR-LQDSGVELLCE F----------------------------------------------------------- --------------------------LRAPQCQ--------------------------- -----------------------------------------------------------L ESL--GLRGCSLSGDSCT-------------------------------------SLAST LKSKTDPSH---------------------------------LREVVLSYNR-LQETDLK ML---------------------------------------------------------- ------------------------------------------------------ >D_rerio_ENSDARP00000091430 ------------------------------------------------------------ ----------------------MQKSKSPESSVASVTSDQSTDPPQNYRGHTELTFSHDH LHAEV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HKTFRSNLLTKFQCVSEGTATDKSPTLLNEIYTELYITEGDSGEINNEHEVRQIET QSRRSTTEDTPI-QCRDIFTALPGQHKAIRT--VLTKGVAGIGKTVSVQ-KFILDWAEEK ENQD-VQLIFPLPFREINL-MKDRTLSLADLLHVF--FPETKEM--EISRD-GYKVLFIF DGLDECRLS------LD--FNSG----VKLCDISESASVEDLLMNLIAGNLLPSALIWIT SRPAAADLIPSAFVH-RLTEVRGFTDPQKEEYFRKRIRDQR---------LADEIIQHLK SCRSLFIMCHIPVFCWISATVLE-----EMMRG--SRKGE--IPKTLTEMYTHFLIIQTC IRHEKHY--------EKKLKDEEMILKLGKLAFRQLM-KGNLIFYEEDLRECGIDESE-A SVYSGLCTQIFREELGLFQGKVFCFVHL-SIQEHLAALYVLLSFLLYERDELSENRRSKY AHWFK-------------------RQTISDLH--QRA--VDKALQSR-NGHLDLFLRFLL GLSLKSNQRLLNNHLTQVGNI-SYSQE-KTVEYIKTQIK--------------------- -----MNP-------SPEKSINLFLCLNEL-GDHSLVNEVQEYVRSG------------- -----DLSGSRFSSSQWSAVV-----FI-LLTLEQ------------------------- ------------------------------------------LDEFNLRRYVIGYGHQTQ -------TQKFQTP------DKVLQKL----LPVVEASRSAVLFDCGISD-----KGCAA LASALR-----------------SNSSNLRELDLSYN-IVGD-SGVKLLSAGLKDPHCKL EKLRL-RCCGVSDEGC--ADLASVLRSNSSNL-RELELSKNINVGDSGVKLLSAGLK--D -PHCKLEKLR-------------------------------------------------- -----------LGYCGVSDEG----CAALASVLRSNSSNLREL----------------- --------------------------------------------DLSDNKIVDSGVKRLS AGLKDPQCKLETL----------------------------------------------- ---------RLINCDVSGKGCAALASALRSNSSNL------------------------- ------------------------------------------------------------ ---------------------------------------RELNLSENK-VGDSGVKRLSA G----------------------------------------------------------- --------------------------LKDPHCK--------------------------- -----------------------------------------------------------L EKL--TLNYCGVSDASCA-------------------------------------DLASA LRS--NSSN---------------------------------LRELNLKWNR-VEGIGVK WLSDLRD-----DPHYK---LETLHISWGFIC---------------------------- ------------------------------------------------------ >T_rubripes_ENSTRUP00000002822 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------KLLFIF DGLDESRLS------LD--SNNQ----QVISDVTQVSSVNVLLMNLIQGNLLPSALIWIT SRPAAANQIPPSCVD-RMTEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLHTMCLIPVFCWITATVLE-----DMLTT--EQRGA--LPQTLTDLYSHFLMVQTK RKKQ----------------NKEVLLKLGQLAFEHLE-NGNIIFYPEDLEQCGLDVSE-V SVYSGVCTEIFRRESVIFQKSVYCFVHL-SIQEFLAAVYMFHCYTNKNT----------- -------------------------VSVDSFL--WEV--IRKSLKST-NGHLDLFVRFLH GLSLESNQRILGGLLNRTDNH-PETIQ-RVINNLKEMNT--------------------- -----DGI-------PPDRSINIFHCLMEM-KDHSVHQEIQELLKSE------------- -----KKSEQNLSEIHCSALA-----YL-LQICEELQEGYVSPD-----VLVRI------ ------------------------------------------RKTINLSQV--------- ------------------------------------------------------------ -------------------------------------------VLISNYPNVLHI----- ------------------WLFFNVRFSNPSHL-TELDLS-QNILQDSGVKLLCSGLE--S -PNCKLETLS-------------------------------------------------- -----------LNN-FLSETS----CGSLASALRSNRSHLTEL----------------- --------------------------------------------DLSHNNLQDSGVEPLC SGLESPNCKLETLRSAHEFHYFTTKRQSSYFFLNFQISAHEVKKSVLLFKKKKIIHKKMN KFKFILSLFRLIDCSLSETSCGSLASALKSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------TELDLSENN-LQDSGVKLLCS G----------------------------------------------------------- --------------------------LESPNCK--------------------------- -----------------------------------------------------------L QTL--RLRRCRLSEISCG-------------------------------------SLASA LRS--NPSH---------------------------------LTELDLSENK-LKDSGVK LLSDLVI-----SPNYK---LATLTNSLNKASNRLLSVKTFYLSLSVCLSVC-------- ------------------------------------------------------ >T_rubripes_ENSTRUP00000020197 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LFSLALVSE LQEVLEGHKISLKRRCEHVTEGTNEAGSGILLNKIYTEVYITEGQSEEVNTQHEVRQLER TSKKN-IQDTPI-KCQDIFKALSEQEKHIRV--VLTNGVAGVGKTFSVQ-KFTLDWAEGL ENQD-ISLVLLLSFRELNL-IKEEQFSLLSLLHVF--HPTLQKLRAEDLT--LCKLLFIF DGLDESRLS------LD--SNNQ----QVISDVTQVSSVNVLLMNLIQGNLLPSALIWIT SRPAAANQIPPSCVD-RMTEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLHNHVSDP---------------------------------------------SVL RKKQKYEG--TERSEELTEADKEVLLKLGQLAFEHLE-NGNIIFYPEDLEQCGLDVSE-V SVYSGVCTEIFKREIVIFQKSVYCFVHL-SIQEFLAAVYMFHCYTNK------------- ------------------------FQSLDDFL--KCV--MLKSLKST-NGHLDLFVRFLH GLSLESNQRILGGLLNRTDNH-PETIQ-RVINNLKKIDS--------------------- -----CKI-------SPDRSINIFHCLMEM-KDHSVHQEIQEFLKTE------------- -----KKSEQKLLKIHCSALA-----YL-LQM---------------------------- ------------------------------------SEEV--LDELNLRKYNTSA----- ------------------------------------------------------------ -----------------------------------------E-GRFRLIPAVR------- ------------------------------------------------------------ --NCRKADFS-------------------------------------------------- -----------FS--RLTELH----CEVVASALKSNPSHLTEL----------------- --------------------------------------------DLSENNLQDSGVKLLC SGLESPNCKLETL----------------------------------------------- ---------RLGLCSLSETSCGSLASALKSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------TELDLSENN-LQDSGVKLLCS G----------------------------------------------------------- --------------------------LESPNCK--------------------------- -----------------------------------------------------------L QTL--RLSFCCLSETSCG-------------------------------------SLASA LRS--NPSH---------------------------------LTELDLSENN-LQDSGVK LLSDLVI-----SPNYK---LETL------------------------------------ ------------------------------------------------------ >X_tropicalis_ENSXETP00000019187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PQA--VLVSGVPGVGKTTLMQ-KFVYDWANGN LYQ-RFAFVFSFKFRDLSN-KEELS--LAQMIVDE--YPYLHSQLERILQN-PKHLLFIF DGLDESKDQ------ID--LKQN----QLCTNPRSMQTVSAIVSSLVRQSLLPGCSVLIT SRPTRLATVETSVFN-RISEIMGFFPKEREKYFLHFFRDYT---------MGEKAFHYVR ENGMLYTFCYIPSYCWIICTVLSMCFRAQRANSA-QTVEF--LPKTVTQLYASFISNILA NHCQA------------GTIDKNFLISIGRMAEYGVN-SRILSFTKEDLDGFSVDASS-- -HL--ATSFVMESGQP--PHVSYSFLHL-TIQEFMAALGYYLDYSPEGL----------- ----------------------------------QKA--LEEAKSTE-DGRGEIFLRFIS GLSDSSTRSLLKPYVG-DLSA--PAAK-HVISFLQKSIP--------------------- -----NLN---SQNPDNRKVLNVFACLTES-RNKVLVSSSIGLNRQL------------- -----DFRDFYLAPLDCTVLA-----FI-LESCRETELLDLGAC---------------- ---------------FIQTEGL-ERISAALHTVTD-DT---------------------- --------------------HCFISR---------------------------------- --GNVL------------------IETNLLDIRLANN-NLRD-EDVQCIYSILTHPQCRI QRLSL-RNNGLTELSC--LPLALAVSEN-TSL-RDLDLS-KNKLAGEDFYKLLEVLS--A -PMCRIERLA-------------------------------------------------- -----------LQEAKLTPQY----AASLLC-LTNNPN-LTHLNISSNFFGDAGYPHIKE RDVCHRQCWETELLDLGTCFIQTEGLERISAALHTVRDLSVNHFQLTNNNLRDEDVPCLY SILTHLQCRIQKF----------------------------------------------- ---------SLRNNGLTETSCLPMALAVSEN-TSL------------------------- ------------------------------------------------------------ ---------------------------------------RDLDLSKNK-LAGDDFYQLLE V----------------------------------------------------------- --------------------------LSAPTCRIERLA---------------------- -----ISSNFFGNAGYPHIQKLILEHPSLREINLATNNLRDEDVEFIYSMLTHPQCR--I KKL--SLRNNGLTEECCG-------------------------------------QLAWA IKE---NTS---------------------------------LRDLDLSKNK-LAGEDFY QLLEVFS-----DPTCQ---IEHL------------------------------------ ------------------------------------------------------ >O_latipes_ENSORLP00000001319 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------VLTSGIAGIGKTFLVQ-KFTLDWAEGL ENQD-VISVVPLSLRELNL-VRDEQYSLHSLIQLF--HPAFQKIPAEQLD--VNKLLFIF DGLDESRLS------LD--FHNS----QVVSDVTQKSSVSVLLTNLIQGRLLPSALVWIT SRPAAAHQIPEKLVD-RLTEVIGFDDSQKEEYFRKRFSDEE---------QFSRIISHIQ SSRSLHVMCRVPIFCWITATVLE-----HMLTT--EDRGE--VPTTLTDMYSQFLMVQTK RKKK-YQQGCETCPQEVTEADREVLLKLGKLAFKHLE-KGNIMFYQEDLQQCGLDVTE-A LLHSGVCTEIFRRECMIFQRPVYSFVHL-SVQEFLAAVYMFYCFTIKNTEVLENFLVSQK QSNRPSTLQSFFNMFWPSEKDVPHFPTLDEFL--SKV--MEKSLQSD-AGQLDLFVRFLH GLSVESNQRLLGSLLCHTENS-AESLQ-KVIDNLKMMKS--------------------- -----YSS-------SPDRSINIFHCLVEV-KDLSVHQEIQEFLQTE------------- -----NRSDKV-SAEPLSSLK-----FT-RAIC--------------------------- ------------------------------AKSLKSRPSH--LRELDLSHNTLQDSGMKI L------SDGLESP------NCRLETLRLRS--------------CTMSE-----AGCTA LVSALK-------------------SSHLMELDLSDN-RLCD-SAVRHLCGFLQSSHCTL KTLRL-SSCRLSESSC--AALLSALKTNPSHL-TSLDLSDNVNLLDSGAERLCGLLK--G -PQSRLRTLR-------------------------------------------------- -----------LRSCSLSVRS----CASLASALKTNPLHLTQL----------------- --------------------------------------------DLSDNKLQDSGVEQLC DFLMVPDCRLETL----------------------------------------------- ---------RLEDCSLSEKSCAVLASALISIPSHL------------------------- ------------------------------------------------------------ ---------------------------------------THLDLSFNK-LRDSAMKHLCG F----------------------------------------------------------- --------------------------LRSPHCS--------------------------- -----------------------------------------------------------L HTL--RLEDCRLSATSCS-------------------------------------TLFST LQS--SSSR---------------------------------LTELDLNRND-LKASDVQ KLLDLVE-----SPDCK---LETL------------------------------------ ------------------------------------------------------ >G_gorilla_ENSGGOP00000002851 ---------------------------------------------------MSDVNPHSD TPIPFSSSSTHSSHIPPSTFSCYPGS-PCENGVMLYMRNVSHEELQRFKQLLLTEL-S-- ----T-GTM-PITWDQVETASWAEV-VHLLIERFPG-RRAWDVTSNIF-----AIMNCDK MCVLVRRE-----------------------------INXXXXXXXXXXXXXXXXXXXXX ------------------------------------------------------------ ----XXXXXK-------------------------------------------------- ----IQQYKSNVMEKFFPIWDITTWPGNQRDFFYQDVH---RHEE--------------- -------------YLPCLLLPKRPQGRQPKT--VVIQGAPGIGKTILAK-KVMFEWARNK FYAHKPWCAFYFHCQEVNQ-TTDQS--FSELIEQK--WPGSQDLVSKIMSK-PDQLLLLL DGFEELTST------LI--DRLE----DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIM IRFSSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTE---------EGDQVLSFAM ENTILFSMCRVPVVCWMVCSGLK-----QQMERG-NNLTQ--ACPNATSVFVRYISSLFP TRAEN----------FSRKIHQAQLEGLCHLAADSMW-HRKWVLGKEDLEEAKLDQTG-V TXF--LGMSILRRIAG--EEDHYVFTLV-TFQEFFAALFYVLCFPQRLK--N-------- --------------------------FHVLSH--VNIQRLIASPRGS-KSYLSHMGLFLF GFLNEACASAVEQSFQCKGXX--XXXX-XXXXXXXXXXX--------------------- -----XXX---XXX-X-XXXXXXXXXXXXX-XXXXXXXXXXXXXXXX------------- -----XX-XXX-XXXXXXXXX-----XX-XXXXXXXXXXXXXXX-XXXXXXXXXXXX-XX X----------XXX-APESNGL-HPWWQDLCSVFX-XXXX--XXXXXXXXXXXXXXXXXX X------XXXXXXX------XXXXXXXXXXXX-------------XX-----X--XXXXX XXXXXX------------------XXXXXXXXXXXXX-XXXX-XXXXXXXXXXXXXXXXX XXXXL-EDCLATPRIW--TDLGNNLQGX-GHL-KTLILR-KNSLENCGAYYLS------- -VA-QLERLS-------------------------------------------------- -----------IENCNLTQLT----CESLASCLRQSKM-LTHL----------------- --------------------------------------------SLAENALKDEGAKHIW NALPHLRCPLQRL----------------------------------------------- ---------VLRKCDLTFNCCQDMISALCKN-KTL------------------------- ------------------------------------------------------------ ---------------------------------------KSLDLSFNS-LKDDGVILLCE A----------------------------------------------------------- --------------------------LKNPDCT--------------------------- -----------------------------------------------------------L QIL--ELENCLFTSICCQ-------------------------------------AMAXM LRK---NQH---------------------------------XRHLDLSKNA-IGVYGIL TLCEAFS-----SQKKR---EEVIF----CNPAWTRITSFSPTPHPPDFTGKSDCLSQIN P----------------------------------------------------- >T_rubripes_ENSTRUP00000005495 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LKRRCEHVTEGTNEAGSGTLLNKIYAELYITEGQSEEVDTQHEVRQLEI TSKKN-LQDTPI-KCQEIFKVLSEQQRHIRV--VLTNGVAGVGKTFSVQ-KFSLDWAEGL ENQD-ISLVLPLSCRELNL-IRDEQHSLLSLLHVF--HPTLQKIRAEDLT--VWKLLFIF DGLDESRFS------LD--FNKH----QVISDVTQVSSVEVLLVNLIQGNLLPSALIWIT SRPAAAYQIPPSCVD-RITEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRTLHIMCLIPVFCCITAIVLE-----DMMTR--DQRGE--LPKTLTDLYSHFLMVQIK RKKQKYGG--KQRPEELTEADKELLLKLGRLAFEHLE-KGNIIFYSEDLEQCGLDVSE-V SVYSGVCTEIFKRESVIFQKSVYCFVHL-SIQEFLAAVYMFHCYTRKDTVVINQFLKYIS GFTWLYTNNDP-------------VTSLDDFL-------------SK-NGHLDLFVRFLH GLSLESNQRILGGLLDQTESH-PETIQ-KVLNNLKEVNS--------------------- -----DKV-------SPDRSINIFHCLTEM-KDQSVHQEIQEFLKSK------------- -----RKSERRLSEIHCSALA-----YL-LQM---------------------------- ------------------------------------SEEV--LDELNLQQYNTSE----- ------------------------------------------------------------ -----------------------------------------E-GRRRLIPG--------- ------------------------------------------------------------ ---CILSLFS-------------------------------------------------- -----------LSSCSLSEIS----CDSLASALRSNPSHLRVL----------------- --------------------------------------------DLSYNSLEDSGVKLLC SGLESLNCKLETL----------------------------------------------- ---------RLIDCSLSEISCDFLASALRSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RVLDLSWNQ-LKDSGVKQLCG F----------------------------------------------------------- --------------------------LQDPLCR--------------------------- -----------------------------------------------------------L ETL--SLIDCSLSAISCD-------------------------------------CLSSA LRS--NPSH---------------------------------LRVLELNDNN-LEDSGVK PLSDLVE-----SPIYK---LETL------------------------------------ ------------------------------------------------------ >R_norvegicus_ENSRNOP00000048506 ------------------------------------------------------------ ------------------------MVDTSGYGLLKHLRKLSDGEFWSFKELLRKEPEK-- ----F-KLK-PISWMKIENASKEEL-VMLLNTHYP--KQAWDMALSLF-----LQVNRED LSIMAQKK---------------------------------------------------- ------------------------------------------------------------ ------RRYK-------------------------------------------------- ----QTKYKKFMKTTFQSIWTLESNICIPDRSYHLIVE---HQYR--------------- -------------KLQNIF----DSESEPVT--AVVTGPTGEGKTVFLR-KAMLDWASGI LWQNRFQYVFFFSVLSLNN-TTELS--LAELISSK--LPESSETLNDILSD-PKKILFIL DGFDYLKFD------L---ELRT----NLCNDWRKILPTQIILSSLLQKIMLPESSLLLE LGHISLPKIFPLLQYPRDITIQGFSERCLKTYFISFFNTE----------KGIEVFENLK SNQ-MLKLCSNPYLCWMFCSCLK-----WQFDRE-EEAYF--QAKTDSVFFTSFMVSAFK SAYAS----------NPPKQNRAQLKSLCTLAVEGMW-KQLFVFDSEDLRRNGISESD-K AVW--LRMKFLQNHDN-----HIVFYHP-TLQLYFASMFYFLKQDKDTH--V-------- --------------------------PVIGSI--PQL--LRKIYARD-HTQWLQIGIFLF GLATEQVASLLKPYFGFIQHR--DVRQ-EVMRYLKSLSQ--------------------- -----REC---CEK-L-ERPQNLFACLRDN-KEEKFVREVVDLFEEI------------- -----TV-DIT-NSHVLSIIA-----NH-LQKSSKLKKLHLHIQ-KRVFLEIHDPEYSDS -----------ETF-TQDKKNA-AEYWKKLCHIFV----N--LHVLDLDSCNFNKQVIEE L------CNVLSPSPKIPLMAFKLESLLCSFM-------------TN--------FGDGS LFHTLL------------------QLPHLKYLNLYGT-NLSN-SRIENLCSALRRSTCKV EELLIVYKCGINFKS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >X_tropicalis_ENSXETP00000019213 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HRKRCVPQA--VLVSGVPGVGKTTLMQ-KFVYDWANGN LYQ-RFAFVFFFKFRDLNN-KEELS--LAQMIINE--YPYLHSQLDRIFRN-PEKLLFVF DGLDKNKSS------TD--FKSS----KLCTNPHSIGTLNVIVSSLVRQSLLPGCSVLIS SRPTRLATVKTSVFH-RILEIMGFFPKEREKYFLHFFRDYT---------MAEKAFHYVR ENGMLYTFCYIPSYCWIICTVLSMCFRAQRANSA-QAVEF--LPKTVTQLYASFISNILA NHCQA------------GSIDKNFLISIGRMAEYGVS-NQILSFTKDDLETFNVDTSS-- -HL--ATSFVIESGQP--PHVSYSFLHL-TIQEFMAALGHYLDYSPEGL----------- ----------------------------------QKA--LEEAKSTE-DGRGEIFLRFIS GLSDSSTRSLLKPYVG-DLSA--PAAK-HVISFLQKSII--------------------- -----TLQ-----NPDNRKVLNVFACLAES-RNKALVSSSIGSNKQF------------- -----QFSEFYLVPLDCTVLA-----FI-LESCRETELLDLGDL-HVLKDVHSLLSC--- ---------------LRNNGLT-EDSCAALTLAVE-GNNS--LRDLDLSKNKLSGKDLNK L------LEVLSAP------ACRIERL----------------------GNFFGDAGYPH IQKLIL------------------EHPSLREIRLTNN-NLRD-EDVPCLYSILTHRQCRI QRCSL-RNNGLTELSC--LPMALAVSEN-TSL-RDLDLS-KNKLAGEDFYQLLKVLS--A -PTCRIERLA-------------------------------------------------- -----------LQEAKLTPEY----TESFLS-LTNNPN-LVSL----------------- --------------------------------------------KLTNNNLRDEDVPRIY SILTHLQCRIQRL----------------------------------------------- ---------SLRNNGLTETSCLPMALAVSEN-TSL------------------------- ------------------------------------------------------------ ---------------------------------------RDLDLSKNK-LAGEDFYQLLE V----------------------------------------------------------- --------------------------LSAPTCRIECLALQEAKLTPEYTESFLSLTNNPN LVSLNISSNFFGDAGYPHIQKHILTHPSLREIRLQEAKLTPEYTESFLSLTNNPN----- ------------------------------------------------------------ ------------------------------------------LVSLNISSSF-FGNAG-- ------------------------------------------------------------ ------------------------------------------------------ >T_nigroviridis_ENSTNIP00000008085 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LLSLGLVDD LQKVLEGHKISLKSKCEHVTEGTQEAGRGTLLNKIYTELYITEGRNEEVNTQHEVRQLEM TSKKN-VQDTPI-KCHQIFNALSDKQKHIRV--VLTNGVAGIGKTFSVQ-KFSLDWAEGL ENQD-ISLLVLLSFRELNL-IKDEQFSLLSLLHIF--HPTLEKIRAEDLN--ACKLLLVL DGLDESRHS------LD--FTNR----EVISDVTRVSSVNVLLVNLIQGNLLPSALIWIT SRPAAANQIPPCCLD-RVTEVRGFTDSQKEEYFRRRFHDED---------LSKRVISHVK ASRSLHIMCLIPVFCWITAKVLE-----DMLTA--GQKEQ--LPKSLTDLYSHFLVFQMR RKKQKYEG--HQRPEELAEADS----------------WGGWRLNIWRREQCGLDVSG-V SVHSGVCTEMFRRENIIFQKSVYCFVHL-SVQEFLAAVYILLNLHEK------------- ------------------------TPPVDDFL--SRV--MKKSLESP-NGHLDLFVRFLH GLSLKSNQRILGRLLNQTENH-PDTTQ-KTINNLKEMKS--------------------- -----DTV-------SPDRSINIFHCLLEM-NDDSVHQEIQEFLKSQ------------- -----KKSEKRLSEIQRSPLA-----YL-LQMVHTSEEGRRRLI-----PAVRNCRKAQL ISS----------------NLS-ETHCEFVASALTSSPSE--LRELNLSESRLQESGVKL L------CAGLESP------NCKLETLILNS--------------CGLSE-----ISCGS LASSVT-----------------SNPSFLKELNLNSN-KLLD-SGVKLLCAGLESPNCKL EILRL-LDCSLSERSC--HFLASALKSEPSRL-RVLNLS-ENQLLDSGVKLLCAGLE--S -PNCKLEILR-------------------------------------------------- -----------LWNCGLSERS----CDYLASALTSNPSHLRIL----------------- --------------------------------------------NLSENKLQDPGVKRLC AYLQNPLCQLDTL----------------------------------------------- ---------SMRHCSLSEKSCGCLATALRSSPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RVLNLSHNE-LQDSGVELLCD F----------------------------------------------------------- --------------------------LQNSLCE--------------------------- -----------------------------------------------------------L ETL--RMWNCGLSESSCN-------------------------------------SLAAA LEC--NPSH---------------------------------LRELNLSENK-LQDSGVK LLSDLVN-----SPTYK---LETLGLTGI------------------------------- ------------------------------------------------------ >T_nigroviridis_ENSTNIP00000009170 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MLLVRD LQEVLEGHKISLKSRCERVTEGTNEAGSGTLLKQIYTELYITEGQSEEVNTQHEVRQLER TSKKS-LQDTPI-RCQDIFRTFSEQQKKIRV--VLTNGVAGVGKTFSVQ-KFSLDWAEGL ENQD-LSLVLLLSFRELNL-VRDEQLSLLTLLHVF--HPTLQKIRAEDLT--VWKLLLIF DGLDESRLS------LD--FRNK----QVISDVTQVSSVNVLLVNLIQGNLLPSALIWIT SRPAAANQVPPTCVD-RMTEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLDIMCQIPVFCWISATVLE-----DMLTT--DQRGE--LPTTLTDLYSHFLMVQTK RKKQK--------AEELTEADKEVLLKLGQLAFEHLE-NGNIMFYPEDLERCGLDVSE-V SVFSGVCTEIFRRESVIFQKSVYCFVHL-SIQECLAALYMFHCYTEKNKVVMKTFLKQKP FSW---------------------FHHVDIFL--WDT--TMKSLESK-NGHLDLFVRFLH GLSLESNQRILGGLLKQTVNH-PGSIQ-KVINNLKEMDS--------------------- -----DGI-------SPDRSINISHCLMEM-KDHSVHQGDPTVPEIK------------- -----GETREE--------VS-----VS-IPM---------------------------- ------------------------------------SEEV--LDELNLQKYKTSE----- ------------------------------------------------------------ -----------------------------------------E-GRLRLVPAVR------- ------------------------------------------------------------ --NCRKAEFR-------------------------------------------------- -------------SSGLSEIH----CEVVASALKSSPSHLREL----------------- --------------------------------------------DLSENNLEDPGVELLC SGLESPNCHLETL----------------------------------------------- ---------RLTGCSLSEISCSHLGSVLKSSPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSLNN-LEDPGVELLCS G----------------------------------------------------------- --------------------------LESPNCH--------------------------- -----------------------------------------------------------L ETL--RLTGCSLSAISCS-------------------------------------HLVSA LKS--NPSH---------------------------------LRELDLSGNH-LEDPGVK RLSALVT-----SPNYQ---LETLRP---------------------------------- ------------------------------------------------------ >T_rubripes_ENSTRUP00000006167 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LKRRCEHVTEGTNEAGSGTLLNTIYTELYITEGQSEEVDTQHEVRQLEI TSKKN-IQDTPI-KCQDIFKVLSEQQRHIRV--VLTNGVAGVGKTFSVQ-KFCLDWAEGL ENQD-ISLVLPLSCRELNL-IRDEQHSLLSLLHVF--HPTLHKIRAEDLT--VWKLLFIF DGLDESRFS------LH--FNKH----QLISDVTQVSSVGVLLVNLIQGNLLPSALIWIT SRPAAAYQIPPSCVD-RITEVRGFTDSQKEEYFRRRFSDED---------LSKRIISHIK ASRSLHIMCLIPVFCWITAIVLE-----DMLTR--DQRGE--LPKTLTDLYSHFXSLL-- -----------------------------------------------------LCSSE-H SGVSG------------------CRLHVPPLHQERHSGYKFAGLLNNDP----------- ------------------------ATSLDGFL--RRA--LMKSLESE-NGHLDLFVRFLH GLSLESNQRILGGLLDQMENH-PETIQ-KVLNNLKE-NS--------------------- -----NKI-------SPERSINIFHCLMEM-KDQSVHQEIQEFLKSG------------- -----EKSERELSEIHCSALA-----YL-LQM---------------------------- ------------------------------------SEEV--LDELNLLQYKTSEEQYPL QWSFLQFFISIAASIK----NNRSHKLTDYHE-----------------------ITVMS LSGNFI-----------------TSNKRCSENDLKGN-RQIE-QKLRAIDATRDSD--VI DRIAE-KSQSLTHYFCFMHNRLSAMTSNPSHL-RELSLS-WNQSLTDAVKLLSSAMM--H -PNCRLETLR-------------------------------------------------- -----------LWRCSLSETS----CDSMASALKSNLSHLRVL----------------- --------------------------------------------DLSTNTLQDSGVKQLC SGLESPNCKLERL----------------------------------------------- ---------SIVNSGLTQISCGSLASALRSNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------RELDLSQNQ-LKDSGVKLLCG F----------------------------------------------------------- --------------------------LHFPNCR--------------------------- -----------------------------------------------------------L ETL--GLSYCSLSEISCD-------------------------------------SLASA LRS--NPSH---------------------------------LRELDLGENQ-LQDPGVK LLSDLVE----------------------------------------------------- ------------------------------------------------------ >O_latipes_ENSORLP00000003302 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------MRV--VLTSGVAGAGKTFSVQ-KFTLDWAEGL ENQD-ISAVVPLSFREMNL-IRDEQHSLLTLIQRF--HPTFQKIPADQLS--VWKILFIF DGLDESRLS------LD--FNNS----QVVSDVTQKSSINVLLTNLIQGRLLPSALVWIT SRPAAANQIPPSCVD-RLTEVRGFNDAQKEEYFRKRFTDEE---------LSSRIISHIK GSMSLYIMCEVPVFCWITAVVME-----NLLTT--EQRGE--LPTTLTDMYSHFLMVQTK RKKNKYQQEHEENPQELTEADMEVLLKLGRLSFEHLE-KGNIMFYQEDLEQCGLDVTE-A SLYSGVCTEIFRRECEIFQKPVYSFVHL-SVQEFLAAVYMIHCYNKKDC----------- ----------------------MENPSLDEFL--NRV--MEKSLQSQ-TGRLDLLVRFLH GLSVESNQRLLGGLLGQTEKN-PETIQ-RAINNLKEINS--------------------- -----KGV-------SPDRSINIYHCLMEM-KDLSVYQEIQEFLKIA-LRVKSLAHLEPP AFSSQHLGTPSTPFVTVVSSA-----FL-MMMLLESGEVQC------------------- -----------------------FHCLRFVASALKSNPSH--LTVLDLSNNSLQD-SMKV L------CSGLESP------NCRVQTLSFRLK------------ECSLSE-----INCEA LGSALK-----------------ENPSNLTELDLSDNYSLHD-SGFLLLCGFLESPDCRL QTLRL-MGCSLSGISC--EELGSALKKYPSNL-KELDLSWNWKLQDSGFLHLCGFLE--S -PDCRLQILR-------------------------------------------------- -----------LKRGSLSTIS----CKALGAALKKNPSNLTEL----------------- --------------------------------------------NLSRNSLKDSGFLHLC GFLESPDCRLQTL----------------------------------------------- ---------RLKRCSLSTISCKALGSALKKNPSHL------------------------- ------------------------------------------------------------ ---------------------------------------TELDLTENN-LQDSGFLHLCG F----------------------------------------------------------- --------------------------LESPDCR--------------------------- -----------------------------------------------------------L QIL--RLMGCSLSEVSCK-------------------------------------VLASA LKK--NPSN---------------------------------LTELDLNGNQNLQDSGVL HLCGFLE-----SPDCR---LQTLGSDSMLWLCRLSKTSCANLVSALKSNPSHLTELDLS FNNLQSSDVQQLQDLMKSPKSKLQTL---------------------------- >T_rubripes_ENSTRUP00000004992 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LKGKFRWVSEGLTKAGRSTLLNQIYTELLITEGGSGGVNNEHEVRYIEQ ASRKAKTQEITV-GREDIFKPLPGRDKSIRT--VMTTGVAGIGKTVLTQ-KFTLDWAENK TNQE-TQFIFPFTFRELNY-LKGKTYSLVGLVHDF--FPETKQAGLCRFD--HFRVVFIF DGLDECRLP------LD--FRSN----KTVTDPTESASVDVLLTNLIKGTLLPSARLWIT TRPAAAALVPADCID-RATEVRGFTDLQKEEYFRKRLGDRQ---------HASTIASHVK MSRSLHIMCHIPVFCWITATVLE-----DVLNS--AEGAQ--LPKTLTEIYIHFLVIQLK LKNVKYDGRGETDS-HWCPQSRDLVECLGKLAFEQLQ-KGNVIFYESNLTECGIDVTA-A TVYSGMFTQIFKEEKSLYQTKVFCFIRL-SVQEFLAALYVHLRQKIKFK----------- --------------------------WPKQDL--NSL--HRSVGQSD-AAAWS------- --------------ADKTEGA-SRAIL-KTRTYLKKKID--------------------- -----PNL-------SPERNINLLHCLNEL-KDSSLLEEEALTLLTC------------- --------------LLLSGQL-----WS-LYYCHQRKI---------------------- ------------------------------------------WTHLTLRNTLIQRKELRC CFQCSKPPEKLCTYPTD---MHYLDSMGGKNQCIFKCIILFRLTGCNLSK-----DNCKL LGSVLS-----------------SESSALRELDLSNN-NLEQ-PKMKLLAAGLESPCCNL QSLRL-SSCVITEDSC--ACLALALQTNPSHL-KELDLS-YNPLGDGGVMVLSAALK--D -PHCMLHKLR-------------------------------------------------- -----------LSGCNLSEGS----CRDLALVLSTETSSIKDL----------------- --------------------------------------------DLSDNNIQDSGLMLLS DGLNSPHCQVEVV----------------------------------------------- ---------RLSGCDLSPKSCEVLASALNFRALSL------------------------- ------------------------------------------------------------ ---------------------------------------RELELNNNN-LGDSGVELLSA A----------------------------------------------------------- --------------------------LKAPQCS--------------------------- -----------------------------------------------------------L QTL--RLSGCLVTDVGCA-------------------------------------SLASA L----NGSC---------------------------------LRELDLSYNH----PG-- ------------------------------------------------------------ ------------------------------------------------------ >M_mulatta_ENSMMUP00000016497 ------------------------------------------------------------ ----------------------WRHLSSQSGTMWWNLKELRKEEFWKFKELLKHEPLT-- ----S-ELK-PITWPELKKPSKEDV-AKLLDKHYPG-EQAWKVTLNLF-----LQISRKD LWTKAQEE-----------------------------MR--------------------- ------------------------------------------------------------ --------NK-------------------------------------------------- ----LNPYRKHMKEKIQLVWERETCVHVPEHFYKEIMK---NESK--------------- ------------------YNDAYAAEARLLT--VVLEGSDGIGKTTLLRKKVMLDWAEGN ---DRFTFVFFLNVCETNG-ITETS--LLELLSRDWNWPESPEKIKDFFSQ-PQQILFIM DGFEQLKFD------L---ELKA----DLYDDWRQQQPTQIILSSLLQK-MIPESSLLIA LG-----------KHPKLIKLPGFPELERKLYFSYFFSEKN---------NVLKAFNFVR DTGPLFILCHNPFICWLVCTCMK-----WWLERG-EDLEI--NSQNTTSLYTS------- ------------------------------LKSGNVD-TYTCIL-PWDLWRNGLSESE-G LMW--AGMKLLQRRG-----NCFTFIHI-CIQEFCAAMFYLLKRPKDDP--N-------- --------------------------PTI-------------------------VGVFVF GNSTEEIISLLETSFGFPLSK--DLKQ-EITQCLKSLSQ--------------------- -----CEA---DRE-A-IGFQELFCGLFAT-QEKEFVTQVINFFEEV------------- -----FI-YIG-NIEHLVVSS-----VC-LKHCQNLTILHMCVE-NIFQISQDHN----- --------------------DK-LVYWWELCLMFI-TNKN--FQTLDMENSRLGDASLAI L------GKVLAQP------ACKLQKLTFTCM-------------PN-----F--GNDSE LFKAVL------------------HDPHMKFLSPYGT-SLSH-TDVRHLCETLKHATCKI EELIL-A----------------------SPM-SHLCLV--------------------- ------------------------------------------------------------ ------------------------------LLLLWDKS-LSLL----------------- --------------------------------------------DLGSNFLEDNGAASLC EALKHTDCNIQEL----------------------------------------------- ---------WLMGCFLTS--------VSLSN-ETL------------------------- ------------------------------------------------------------ ---------------------------------------KTLKLGHDE-IGGAGVKQLCD A----------------------------------------------------------- --------------------------ILT------------------------------- -----------------------------------------------------------L ECL--AMQTWPITHAYC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------