10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000267169 MAALKSWL---------------------------SRSVTSF--FR-YRQCLCVPVVANFK--------KRCFSELIRPWHKTVTIGFGVTLCAVPIAQK--SEPHSLSSEALMRRAVSL P_pygmaeus_ENSPPYP00000005770 MAVLKSWL---------------------------SRSVTLL--FR-YRQCLCVPVVANFK--------KRCFSELIRPWHKTVTVGFGVTLCAVPIAQK--SEPHSLSSEALMRRAVSL C_familiaris_ENSCAFP00000011742 MAALRSWL---------------------------SRSVASL--FR-YRQ--CVPVVANFK--------KRCFSELIRPWHKTVAVGLGVTLCAVPIAQK--LEPHSLSNDALMRRAVSL E_caballus_ENSECAP00000017797 MAALRSWV---------------------------SRSVASLVRYR-YRQ--CVPVAANFR--------KRCFSELIRPWHKTVAVGFGVTLCAVPIAQK--SEPHSLSNDALMRRAVSL P_troglodytes_ENSPTRP00000009467 -----------------------------------------------YRQCLCVPVVANFK--------KRCFSELIRPWHKTVTVGFGVTLCAVPIAQK--SEPHSLSSEALMRRAVSL B_taurus_ENSBTAP00000005496 MAALRSWL---------------------------SRSVSSL--FR-YRQ--CVPVVANFK--------KRCFSELIRPWHKTVAVGFGVTLCAVPIAQK--PEPHSLSNDTLMRRAVSL M_musculus_ENSMUSP00000107214 MAALRSWV---------------------------TRSVCSL--FR-YRQ--RFPVLANSK--------KRCFSELIKPWHKTVLTGFGMTLCAVPIAQK--SEPQSLSNEALMRRAVSL R_norvegicus_ENSRNOP00000046476 MAALRSWM---------------------------TRSVTFL--FR-YGQ--RFPVSANSK--------KRCFSELIRPWHKTMLTGFGVTLCAVPIAQK--SEPQSLSNEALMRRAVSL R_norvegicus_ENSRNOP00000011308 MAALRSWM---------------------------TRSVTFL--FR-YGQ--RFPVSANSK--------KRCFSELIRPWHKTMLTGFGVTLCAVPIAQK--SEPQSLSNEALMRRAVSL M_domestica_ENSMODP00000031429 MAALRSWV---------------------------LRSVSSF--FRAHRNCWHVPVAAKLR--------RCRFSDLVGPWHKTVAAGFGVTLCAIPIAQK--TETHSLSNEALMKRAVSL O_anatinus_ENSOANP00000009922 YAGATSWS---------------------------EDSYSSL--LLTVRR--RGPVATNIK--------RCHFSELARPWPSAVTVGFGLTLCAVPIAQK--FEPHSLSNEALTRRAVSL T_guttata_ENSTGUP00000006354 MAAGGRWL----------------------------RSCCSV-----LRR--SFPVLAGIR--------QRGLAGRSGQWHQAV--GLGVALCAVPVVEQ--QSSGSLSNDALIRRAVSL A_carolinensis_ENSACAP00000000976 ------------------------------------------------RQ--SRPLLAPLR--------TRCASGLRGPWSKAAALGLGATLAAIPITQK--HDPSSLSNEALIRRAASL G_gallus_ENSGALP00000007019 -------------------------------------------------------------------------------WRRAVGAGLGAALCAVPVAEK--QNSASLSNDALIKRAVTL X_tropicalis_ENSXETP00000008194 MASLPRRL---------------------------IWSFSYI-----LRE--SFPIVS--R--------RNCVSLLRASWRKVLSVGVGTSVCAIPVGQR--SEP-TLSSESLIKRAVSL G_gorilla_ENSGGOP00000005240 MAALQSWM---------------------------SRSVASFFXXX-XXX--XXXXXXXXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXK--LEPHSLSSEALMRRAVSL T_rubripes_ENSTRUP00000017934 ------------------------------------------LLASWCNN--FPAILFIVKGNLCLVTNNKKYGFGFGEWHLILALKIGAGFCAVPFKQMYVLQADQLSHDSLIKRAASL D_rerio_ENSDARP00000051182 MQAVKNCGLCASGS---FLKGRTDFLLARRNMAVLRMSAACVQLL---KD--KTSVLCNSSVHQRLL-----QRLPNVARSNAVPFSVGTGLCAMPFTQ----QVENLSHESLIRRASCL O_latipes_ENSORLP00000005265 ----------------------------------------TFLLKSWYNL--PLKDLFGHLKHIPIQLTGKRSRWTTVLTSGVASLAVGGGLCAVPFKEM--LQVDDLSHDSLIKRAASL G_aculeatus_ENSGACP00000014978 MAAL-------------------------------RKVTTCLRLLSFFRS--SAPVLFSIRKPAV----HKAVKWTSIVYTGVASLTVGGGLCAVPFK-----QVENLSHDSLIKRAASL T_nigroviridis_ENSTNIP00000019335 ----------------------------------------------------------------------------------------GAGFCAIPFK-----QADQLTHDSLIKRAASL D_rerio_ENSDARP00000022307 ---------------------------------------------------------------------------------KGVLYFLFVTFCANILIYK--QKPENLSHEDLVRRASSL G_aculeatus_ENSGACP00000014956 MQAVSQCSVCASRAAGGLLRNQTDLSLLRSNTAGLRRGAACMRFIS------MKPGV------------QKLGERIDSEHISVAPSSAGRGLHATPFAQ----QLENLSHDSLIRRAASV O_latipes_ENSORLP00000005325 MQAARQCSVCTRCA---VVRNQTDFSQLQ------RRGVASIRYLSSSES--RRAAV------------RRPANLTNPTNVSLASLSLGHGLW----------QVENLSHDSLIRRAASV T_nigroviridis_ENSTNIP00000009791 MR------------------------------------------------------------------------------------RVGSWPQDFPAT-----QVENLSHDSLIRRAVSL T_rubripes_ENSTRUP00000020450 MQAVRQCSVCAGRVAGGHLWSQVNVSGLQKTV---LRKGTCVRFQR------SESVLVGSR-----------MSAFGDRTDGPNRRRVSSGPQDFPWT-----QVENLSHDSLIRRAASL 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000267169 VTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQL P_pygmaeus_ENSPPYP00000005770 VTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQL C_familiaris_ENSCAFP00000011742 VTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWLTALGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQL E_caballus_ENSECAP00000017797 VTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQL P_troglodytes_ENSPTRP00000009467 VTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITTRNHIQLVKLQVEEVHQL B_taurus_ENSBTAP00000005496 VTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARSHIQLVKSQVQEVRQL M_musculus_ENSMUSP00000107214 VTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQL R_norvegicus_ENSRNOP00000046476 VTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQL R_norvegicus_ENSRNOP00000011308 VTDSTSTFLSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMTAVSLSEMAAEAAYQTGADQASITARNHIQLVKSQVQEVRQL M_domestica_ENSMODP00000031429 VTDSTSTFLSQTTYALIEAITEYTRAVYTLVSLYRQYSSLLGKMNSQEEDAVWQVIIGARVEMSSKQEEYLKLEATGMTAVILFEMAAEAASHSGADQASVTARNHIHLVKTQIQEVRQL O_anatinus_ENSOANP00000009922 VTDSTSIFLSQTTYALIEAITEYTKAVYTLVSLYRKYTSLLGKMSSQEEDAVWQVIIGARVEVTTRQEEFLKLESSWMTAVSLSEMAAEAAYQTGADQASVTARSHIQLVKTQVQEVRQL T_guttata_ENSTGUP00000006354 VTDSTATLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTSKQQEYLRLESSWMTALRLSEMAAEAAYQSGADQASVTARSHIQVVKSQVQEVRLL A_carolinensis_ENSACAP00000000976 VTDSTGTLLSQTTYALIDALTEYTTAVYTLVSLYQKYAHLIGKMNSKEEDAVWQVIIGARVEMTEKQQEYLKLESRWMTALRLSEMAAEAAYQSGADQASVGTHNHIQLVRTQIQEARQL G_gallus_ENSGALP00000007019 VTDSTSTLLSQTTYALIEALTEYTKAVYTLVSLYKQYTNLLGKMNSDEVDAVWQVVIGARVDMTTKQQEYLKLESSWMTALRLSEMAAEAAYQSGADQASVTARSHIQLIKSQVQEVRQL X_tropicalis_ENSXETP00000008194 VADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYTSLLDKMNSNEESAIWQVIIGARVQMKQLKEQYLKYESSWQRAVSLSEMAAEAAYQSGADQASVTVRNHIQIVQTQVQQARNQ G_gorilla_ENSGGOP00000005240 VTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQT-------------------------- T_rubripes_ENSTRUP00000017934 VTDSSTTLLSQTTLALIDAITDYSKAVHTLIALQKRYLDSLGKLSPAEEDRIWQVIIGQRAEVNDRRDQWLRFESTWGSAVKLCETAAEAAYASGAEHASISVRTNMQVAQAQVDEARKL D_rerio_ENSDARP00000051182 VTDSANTYLSQTTLALVDALTQYAKALHTLISLQKRYIASIGKLSPVEEDSIWQVIIGQRVEVSDQLEECKRFESNWMNAINICELSAEAAYNSGAEHACTATKTNLQVAQSKVEEIRKI O_latipes_ENSORLP00000005265 AADSSNGFLSQTTFALIEAITEYAKAVYTLVSLQKRYLDALGKLTQAEEDSVWQAIIGQRAKVNDKKEECRRLEAIWGTAVTLSETAAEAAYASGAEHVCIMAKTNIQVALSQVEQAQNT G_aculeatus_ENSGACP00000014978 VTDSSSTFLSQTSLALVDAITEYSKAVHTLIALQKRYLQSLEKLSPAEEDTIWQVIIGQRSQIRDRQDECKRFESTWVSAVRLCETAAEAAYISGAEHAAITVRSNIQVAQSQVEVAQKL T_nigroviridis_ENSTNIP00000019335 VTDSSTSFLSQATLALIDATTDYSKAVHTLIALQKRYLDALGKLSAAEEDTIWQVIIGQRAEVNDRRDECARFESTWVSAAKLCETAAEAAYVSGAEHASITMRTNMQVAQAQVDEARKL D_rerio_ENSDARP00000022307 VTDSANTFLSQTTLALIDSFTGYIKAVNILVELHKQYEASISKFTPEEENAIWKVILGQRQEVIGRRKNCTHFESCWMTAVNLSQQAAEAAFNAGADQASVAAQSSLQVAQSQVEQVKQL G_aculeatus_ENSGACP00000014956 VTDSSSTLLSQTSLALINALADYSTAVHTRIAVQRRYLAALGKLTPAEKDSFLEVINGQRAKASDRLHECKRIEVTWINAVDLCKMAAEAAHSSGAEQASITVETNIQVAQSQVGEARKL O_latipes_ENSORLP00000005325 VTDSSSTFLSQTSLALSDALTDYAKAVHSRIAFQKRYLSSMGKLSPAEEGSLKQTISSWRAEAAERLSECKRYESTWNSAVNLCKMAADAAYSSGAQQASISIRTNIKVAESQLEEARKL T_nigroviridis_ENSTNIP00000009791 VTDSSSTFLSQSSLALTEALSEYSKTVYTRIAVQRRYLASLGKLTPAEKDSLLEVINSQRAQASDRLDECRHFESSWINAVNMCKLAAEAAHSSGAEQASTMLRAHVQVAQTQVDEARKV T_rubripes_ENSTRUP00000020450 VTNSSCTFLSQSTLALTEALSEYSKAVYTRIAVQRRYLASLGKLTPAEKDSILEVINSQRAQASARMDECRHFESNWINAVNMCKLAADTANSS-------------------------- 250 260 270 280 290 =========+=========+=========+=========+=========+========= H_sapiens_ENSP00000267169 SRKAETKLAEAQIEELRQKTQEE-------------GE------ERAE-SEQEAYLRED P_pygmaeus_ENSPPYP00000005770 SRKAETKLAEAQIEELRQKTQEE-------------GE------ERAE-SEQEAYLRED C_familiaris_ENSCAFP00000011742 SQKAETKLAEAQTEELRQKTQEE-------------GD------ERAE-AEQEAYLRED E_caballus_ENSECAP00000017797 SQKAETKLAEAQTEELRQKTQGE-------------GD------ERAE-TEEEAYLRED P_troglodytes_ENSPTRP00000009467 SRKAETKLAEAQIEELRQKTQEE-------------GE------ERAE-SEQEAYLRED B_taurus_ENSBTAP00000005496 SQKAETKLAEAQTEELRQKTQED-------------GS------ERAEPEEQEAYLRED M_musculus_ENSMUSP00000107214 SQKAETKLAEAQTKELHQKAQEV-------------SD------EGAD-QEEEAYLRED R_norvegicus_ENSRNOP00000046476 SQKAETKLAEVQTQELRQKTQEA-------------SD------EAAD-QEEEAYLRED R_norvegicus_ENSRNOP00000011308 SQKAETKLAEVQTQELRQKTQEA-------------SD------E-AD-QEEEAYLQED M_domestica_ENSMODP00000031429 SQTAETKLAEAQTEELLLKRPEE-PEGVSPQRPSTGGS------PLTN-HEQEAYLRED O_anatinus_ENSOANP00000009922 SQNAETKLAEAQTEELRSRRPEETPEAPRSLRPS----------PLLE-HEQEAYMRED T_guttata_ENSTGUP00000006354 SQKAETKLAEVQTDELIKARGED-------------SSLPQGVLGNAD---DDPYLRED A_carolinensis_ENSACAP00000000976 SQKAESKLAEVQTEELMKLKEEE-------------AL------AAAR-RQASAYLRED G_gallus_ENSGALP00000007019 SQKAETKLAEAQTEELLKTQGEE-------------STLPQGILGSTD-AGEDPYLRED X_tropicalis_ENSXETP00000008194 AHIAEVQLAASQTDEIKRTITEDKGNPPS-------GGSPRSSLSEEE-EIPEAYLRED G_gorilla_ENSGGOP00000005240 ----------------------------------------------------------- T_rubripes_ENSTRUP00000017934 SAEAERKLAEAKVMEVERMSQRV-------------TSMENN---EEE-EVPDAYLRED D_rerio_ENSDARP00000051182 SKEAEKKLAETKAEEIQRMAEYA-------------SSIDIH---DLE-DVPEAYLRED O_latipes_ENSORLP00000005265 SLDADKKLAEAKVMEVERMTQHA-------------ASLQNA--DNEE-DVPEAYLRED G_aculeatus_ENSGACP00000014978 SLDSDKKLAETKVMEVERMMQYV-------------ASSQNN--IEEE-EVPEAYLRED T_nigroviridis_ENSTNIP00000019335 SAEAERKLAESKVMEVERMSQYV-------------TSLENK---DEE-EVPEAYLRED D_rerio_ENSDARP00000022307 MLEAEIQLKDSKAEYSERLQVAL---------------------SEDE-DIPDAYLRED G_aculeatus_ENSGACP00000014956 SADAEKKLAETKVEEIQRMAEYT-------------AFIENG---EEH-EVHEAYLRED O_latipes_ENSORLP00000005325 SAEAEKKLAETKVEEIERMAEYA-------------AFLEGS---EEY-EIQEAYLRED T_nigroviridis_ENSTNIP00000009791 SEDANKKLAETKVEEIQRMAEYA-------------AFRDNN---EEP-ELHEAYLRED T_rubripes_ENSTRUP00000020450 -----------------------------------------------------------