>H_sapiens_ENSP00000259808 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLNVIKMKSSDF-LESAELDS GG-------FGKVSLCFHRT-----QGLMIMKTVYKGPNCI-----EHNEA-LLEEAKMM NRLRHSRVVKLLGVIIEEG-K-----YSLVMEYMEKGNLMHVLKA-------EMS---TP LSVKGRIIL-EIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSK- LNNEEHNELREV----DGTAKK-NGGTLYYMAPEHLNDV--NAK-PTEKSDVYSFAVVLW AIF-A-NKEPYE--NAICEQQLIMCIKSGN-RPDVDD--ITEYCPRE-----IISLMKLC WEANPEARPTF------------------------------------------------- -PGIEEKFRP----------FYLSQLE-----ESVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EYSN--ENAVVKRMQSLQLDCVAVPS------------------- ---SRSNSATEQPGSLHSSQG-LGMGPVEESW-----FAPSLEHPQEEN-------EPSL QSKLQDEANYHLYGSRMDRQT--KQQPRQN----------------VAYNREEERRRRVS HDPFAQQ-RPYENFQN------TEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNG-- -LYSSHGFGT------RPLD----PGTAGPRVWYRPIPSHMPSLHNIPVPETNYL--GNT PTMPFSSLPPTDE--------------------------------SIKYTIY--NSTGIQ IGAYNYMEIGGTSS-SLLDSTNTNFKEEPAAKYQAIF----DNTTSL------TDKHLDP IRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL AQALHQCSRIDLLSSLIYVSQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000030180 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLNVIKMKSSDF-LESAELDS GG-------FGKVSLCFHRT-----QGLMIMKTVYKGPNCI-----EHNEA-LLEEAKMM NRLRHSRVVKLLGVIIEEG-K-----YSLVMEYMEKGNLMHVLKA-------EMS---TP LSVKGRIIL-EIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSK- LNNEEHNELREV----DGTARK-NGGTLYYMAPEHLNDV--NAK-PTEKSDVYSFAVVLW AIF-A-NKEPYE--NAICEQQLIMCIKSGN-RPDVDD--ITEYCPRE-----IISLMKLC WEANPEARPTF------------------------------------------------- -PGIEEKFRP----------FYLNQLE-----ESVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EYSN--ENAVVKRMQSLQLDCVAVPS------------------- ---SRSNSATEQPGSLHSSQG-LGMGPVEESW-----FAPSLEHPQEEN-------EPSL QSKLQDEANYHLYGSRMDRQT--KQQPRQN----------------VAYNREEERRRRVS HDPFAQQ-RPYENFQN------MEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNG-- -LYSSHGFGT------RPLD----PGTAGPRVWYRPIPSHMPSLHNIPVPETNYL--GNT PTMPFSSLPPTDE--------------------------------SIKYTIY--NSTGIQ IGAYNYMEIGGTSS-SLLDSTNTNFKEEPSAKYQAIF----DNTTSL------TDKHLDP IRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL AQALHQCSRIDLLSSLIYVSQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000018096 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLNVVKMKSSDF-LESAELDS GG-------FGKVSLCFHRT-----QGLMIMKTVYKGPNCI-----EHNEA-LLEEAKMM NRLRHSRVVKLLGVILEEG-K-----YSLVMEYMEKGNLMHVLKA-------EMS---TP LSVKGRIIV-EIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSK- LSNEEHNELREV----DGTSKK-NGGTLYYMAPEHLNDV--NAK-PTEKSDVYSFAVVLW VIF-A-NKEPYE--NAICEQQLIMCIKSGN-RPDVDD--ITEYCPRE-----IISLMKLC WEANPEARPTF------------------------------------------------- -PGIEEKFRP----------FYLSQLE-----ESVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EYSN--ENAVVKRMQSLQLDCVAVPP------------------- ---SRSNSATEQPGSLHSSQG-LGMGPVEESW-----FAPSLEHQQEEN-------EPSL QSKLQDEANYHLYGSRMDRQT--KQQPRQN----------------VAYNRGEERRRRVS HDPFAQQ-RPYENFQN------TEGKGTAYCSAASHGNVVHQPSGLTSQPQVLYQNNG-- -LYSSHGFGT------RPLD----PGTAAPKVWYRPFPSRMPSPYNIPVPETNYP--GNT PTMPFSSLPPTDE--------------------------------SIKCTIY--NSTGIQ IGAYNYMEIGGTSS-SLLDSTNTNFKEEPAAKYQAIF----DNTTSL------TDKHLDP IRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL AQALHQCSRIDLLSNLIYVSQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gorilla_ENSGGOP00000012277 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLNVIKMKSSDF-LESAELDS GG-------FGKVSLCFHRT-----QGLMIMKTVYKGPNCI-----EHNEA-LLEEAKMM NRLRHSRVVKLLGVIIEEG-K-----YSLVMEYMEKGNLMHVLKA-------EMS---TP LSVKGRIIL-EIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSK- LSNEEHNELREV----DGTAKK-NGGTLYYMAPEHLNDV--NAK-PTEKSDVYSFAVVLW AIF-A-NKEPYE--NAICEQQLIMCIKSGN-RPDVDD--ITEYCPRE-----IISLMKLC WEANPEARPTF------------------------------------------------- -PGIEEKFRP----------FYLSQLE-----ESVEEDVKSLKX---------------- ------------------------------------------------------------ ---------------XXXX--XXXXXXXXXXXXXXXXXXXX------------------- ---XXXXXXTEQPGSLHSSQG-LGMGPVEESW-----FAPSLEHPQEEN-------EPSL QSKLQDEANYHLYGSRMDRQT--KQQPRQN----------------VAYNREEERRRRVS HDPFAQQ-RPYENFQN------TEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNG-- -LYSSHGFGT------RPLD----PGTAGPRVWYRPIPSHMPSLHNIPVPETNYL--GNT PTMPFSSLPPTDE--------------------------------SIKYTIY--NSTGIQ IGAYNYMEIGGTSS-SLLDSTNTNFKEEPAAKYQAIF----DNTTSL------TDKHLDP IRDNLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL AQALHQCSRIDLLSNLIYVSQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000011125 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLNVIKMKSSDF-LERAELDS GG-------FGKVSLCFHRT-----QGFVIMKTVYRGPNCS-----EHNEA-LLEEAKMM NRLRHSRVVKLLGVIIEEG-N-----YSLVMEYMEKGNLMHVLKA-------EMS---TP LSVKGRIIV-EIIEGMCYLHGKG--VIHKDLKPENILVDDDFHIKIADLGLASFKMWSK- LSKEEHNELKEV----DGTSKK-NGGTLYYMAPEHLNDV--NAK-PTEKSDVYSFAVVLW AIF-A-NKEPYE--NAICEQQLIMCIKSGN-RPDVDD--IIEYCPRE-----IISLMKLC WEANPEARPTF------------------------------------------------- -PGIEEKFRP----------FYLSQLE-----ESVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EYSN--QNAVVKRMQSLQLDCVPVPP------------------- ---SRSNSATEQPGSLHSSQG-LGMGPVEESW-----FAPSLEHQQEEN-------EPSL QSKLQEEANYHLYGSRMDRQM--KQQPRQN----------------VAYNREEERRRRVS HDPFAQQ-RPYENFQN------TEVKGTAYSSAASHGNAVPQPSGLSSQPQVPYRNNV-- -LYSSHGFGT------RPLD----PGTAGPRVWYGPIPSPMSSLYKIPVPETNYL--GNT PTMPFTSLPLTDE--------------------------------SIKYAIY--NSTGIQ IGAYNYMEVGGTSS-SLLDSTNTNFKEEPASKYQAIF----DNTTSL------TDKHLDP IRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL AQVLHQCARIDLLNHLIYVSQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000008268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KPI----------MSLDDIKMKSTDF-LEQEYLDS GG-------FGKVSLCLNRS-----HELVILKKVYTGPKRT-----EYDES-LLEEGRMM HRLRHDRVVKLLGIIIEEG-N-----YALVMEYMTNGNLMRVLKA-------EIS---IP LSVKGRIIM-ETIEGMCYLHGEG--VIHKDLKPENILVDGDFHIKIADLGVASFKTWSK- LTKEEHNEQRKL----NSTSKK-NGGTLCYMAPEHLNDV--NAK-PSEKSDVYSFAIVLW AIF-A-NKEPYE--NAICEQQLIICIKSGN-RPNVED--IIEYCPKE-----IISLMKHC WEANPEVRPTF------------------------------------------------- -AGIEENFRP----------FYLDQLE-----ENVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EYPD--QSALVKRMQSLQIDCVAIPP------------------- ---SRSNSATEQPSSLHSSQG-LGMGPVEESW-----FAPASEHQQEEN-------ELSL QSKLQEEANYHLYGSRMDRQT--KQQPRQN----------------VAYNREEERRRRVS HDPFAQQ-RPYDNVQN------SGIKGLTHPSANSHANAVHQPTGLTSQPHVSYGHNG-- -SYSPHGFGT------RPLD----LGTAGPRARYGANPSHMSSMHKTPVPETNLL--GNT PTIPFISFPSRDE--------------------------------SAKYTIC--NSTGIQ IGHYNYMEIGGMTS-QLLDGTYMNLKQEPASKYQDIF----DNMTSL------TDKHLDP VRENLGKHWKNCARKLSFTESQIDEIDHDYERDGLKEKVYQMLQRWLMREGNKGATVGKL AYALHQCSRIDLLNHLIHISQY-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_familiaris_ENSCAFP00000013721 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RKPT----------MSLDDIKMKSSDF-LEKEHLDS GG-------FGKVSLCLHRS-----HGLVILKKVYTGPKRT-----EYNES-LLEEGRMM HRLRHRRVVKLLGVILEEG-N-----YSLVMEYMEKGNLMHVLKA-------EVS---IP LSVKGRIIM-ETIEGMCYLHGEG--VIHKDLKPENILVDDDFHIKIADLGVASFKTWSK- LTKEEINEQRKL----NSVSKK-NGGTLCYMAPEHLNDI--NAK-PSEKSDVYSFGIVLW AIF-A-NKEPYE--NAICEQQLILCIKSGN-RPDVED--IIEYCPEE-----IISIMKQC WEAKPEIRPTF------------------------------------------------- -AGIEEKFRP----------FYEDQLE-----ENVEEDVTSLKK---------------- ------------------------------------------------------------ ---------------EYPDPAQNSVVKRMQSLQIDCVATPP------------------- ---SRSNSAPEQPSSLHSSQG-LGIGPVEESW-----FAPSLENQQDEN-------QLSL QSKLQEEANYHLYGSRMDRQT--KPL-RQS----------------VAYNREEERRRRVS HDPFAQQ-RPYENIQN------PGVKGLPYSIATSPGNAVHQPKGLTSQPPVRYWNNE-- -LYSPFNFRT------RPLA----LGTTGSRVWYQPNPSHIPSVNKTPVPETNLL--GNT PTIPFSSFPSRDE--------------------------------SVKCTIY--NSSGIQ VGEHNYMEVGGMSS-ALLD---MNVKEEPAYKYQDIF----DNVTSL------TDKHLDP VRENLGKQWKNCARKLGFTEPQIDEIDHDYERDGLKEKVYQMLQKWLMREGNKGATVGKL AYALYQCSRIDLLNYLIHISQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000008367 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RKAA----------MSLDDIKMSSTDF-LEQADLDS GG-------FGKVCLCLHRS-----HGLVILKKVYTGPKRT-----EYNEA-LLEEGRMM HRLRHRRVVKLLGVIMEEG-S-----YSLVMEYMEQGDLMRVLKA-------QVS---IP LSVKGRIIM-ETIEGMRYLHGEG--VIHKDLKPENILVDSDFHIKIADLGVASFKTWSK- LTKEEHNEQRKA----GGSAGK-SGGTLHYMAPEHLNDV--NSR-PSEKSDVFSFAIVLW AIF-A-NKEPYE--NAICEQQLILCIKSGN-RPDVED--IIEFCPRE-----VIDIMRQC WEVNPDNRPTF------------------------------------------------- -AGIEEKFRP----------FYSNQLE-----DYVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------EFPG--QNEIVKRMKSLQIDCVAIAP------------------- ---SRSNSATEQPSSLHSSQG-FGMGPVEESW-----FAPAPDHQPEEN-------DFLL HSKLQEEANYHLYGSRMDRRT--KEQPRPN----------------MAYSSEEERRRRVS HDPFAQQ-RPYENAQS------PGIKGLAYPGVMSHTSAAQQPAGLSSQPQSPYWRDG-- -SFHP--LGV------RPLD----LGTMSPRVWYGPNPGHMPSLYKTPVPETNLL--GNT PTIPFTSLPSRDE--------------------------------SSKYTIH--SSSGIQ IGDSNYMEIGGMSS-SVLDSTYMNLKEEPASKYQAIF----DNTTSL------TDKHLDP VRENLGRHWKNCARKLGFSESQIDEIDHDYERDGLKEKVYQMLQKWLMRAGSKGATVGKL ACALYLCSRIDLVNCLIRISQS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000023962 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLDNIKMASDDL-LERKDLDS GG-------FGKVSLCFHRT-----HGFVILKKVYTGPNRA-----EYNEA-LLEEGKMM HRLRHDRVVKLLGIIIEEG-N-----YSLVMEYMEQGNLMHVLKT-------KES---VP LSVKGRIIV-EIIEGMHYLHDEG--VIHKDLKPENILVDRDFHIKIADLGVASFKTWSK- LTKEEHNKQREA----SSVTKK-NGGTLYYMAPEHLTDI--NTK-PTEKSDVYSFAIVLW AIF-A-NKEPYE--NVICTEQFLVCINSGN-RPNVED--ILEFCPRE-----IISLMERC WQTNPEDRPTF------------------------------------------------- -FGIEKEFKP----------FYLSQFE-----EYVEEDVASLKK---------------- ------------------------------------------------------------ ---------------EYPS--QSPVLKRMFSLQHDCVPLPP------------------- ---SRSNS--EQPGSLHSSQG-LPMGPVEESW-----FSSSPEYPQEEN-------ERSV QAKLQEEASYHAFGIFAEKQT--KSQPRLN----------------EAYNREEERKRRVS HDPFAQQ-RVHENVKS------AGAKGLPYPSTTSHGNAAHQLSGPASQIKVPLWNNG-- -VYNHHGF-----------------GATGTGVWYGPSVSQSYNAYKTPVPETNLP--GSI PTMPYISLAPPDD--------------------------------SIRCTIY--NSSRVQ IGNYNYMDLGPSSQ-PPTN----TCKVESTSRHQAVF----ANTTSL------TDKHLNP IRENMGKQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKL AQALHQCCRTDLLNQLIQASQS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_musculus_ENSMUSP00000021844 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------MQPD----------MSLDNIKMASSDL-LEKTDLDS GG-------FGKVSLCYHRS-----HGFVILKKVYTGPNRA-----EYNEV-LLEEGKMM HRLRHSRVVKLLGIIIEEG-N-----YSLVMEYMEKGNLMHVLKT-------QID---VP LSLKGRIIV-EAIEGMCYLHDKG--VIHKDLKPENILVDRDFHIKIADLGVASFKTWSK- LTKEKDNKQKEV----SSTTKKNNGGTLYYMAPEHLNDI--NAK-PTEKSDVYSFGIVLW AIF-A-KKEPYE--NVICTEQFVICIKSGN-RPNVEE--ILEYCPRE-----IISLMERC WQAIPEDRPTF------------------------------------------------- -LGIEEEFRP----------FYLSHFE-----EYVEEDVASLKK---------------- ------------------------------------------------------------ ---------------EYPD--QSPVLQRMFSLQHDCVPLPP------------------- ---SRSNS--EQPGSLHSSQG-LQMGPVEESW-----FSSSPEYPQDEN-------DRSV QAKLQEEASYHAFGIFAEKQT--KPQPRQN----------------EAYNREEERKRRVS HDPFAQQ-RARENIKS------AGARGHSDPSTTSRGIAVQQLSWPATQT---VWNNG-- -LYNQHGF-----------------GTTGTGVWYPPNLSQMYSTYKTPVPETNIP--GST PTMPYFSGPVADD--------------------------------LIKYTIF--NSSGIQ IGNHNYMDVGLNSQ-PPNN----TCKEESTSRHQAIF----DNTTSL------TDEHLNP IRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKL AQALHQCCRIDLLNHLIRASQS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_cuniculus_ENSOCUP00000010138 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QQAD----------MSLDDIKMKSSDF-LEKADLDS GG-------FGEVSLCFHRL-----HGLVILKKVYTGPKRA-----EYNES-LLEEGRMM HRLKHSRVVELLGVVMEEG-N-----YCLVMEYMEKGSLMHVLKA-------EIS---IP LSVKGRIIA-ETIEGMCYLHGEG--VIHKDLKPENILVDNDFHIKIADLGVASFMTWSK- LTKEEHNEQRKV----NSTRKK-TGGTLCYMAPEHLNDV--NAK-PTEKSDVYSFAIVLW AVL-A-NKEPYE--XXXXXXXXXXXXXXXX-XXXXXX--XXXXXXXX-----XXXXXXXX XXXXXXXXXXX------------------------------------------------- -XXIEERFRP----------FYSSHYE-----EFVEEDVKSLKK---------------- ------------------------------------------------------------ ---------------RYPE--QSAVVKRMQSLQLDCVPVPP------------------- ---SRSNSATEQPSSLHSSQG-FMTGPVEVSF-----FSACPEISQEEN-------EPSL QSKLQEEANYHLYGSRMDKQT--RQPPRQS----------------VAYSREEERRRRVS YDPFAQQ-TPYENVQK------TGIKVHSYPGTTSHSNAAHQPTGLTSQPQLPYWNNG-- -VYSLHGFGT------RPLE----PGTAGQAVWYGPSLSPMSSLYKTPVPETNLL--GNT PTIPFSSLSPAEE--------------------------------SMKCSIY--NSSGIQ LGACNYMEIGGISS-PPLECLCTNL-QEPASKYQAIF----DDTTSL------TDKHLSP VRDNLGKHWKNCARKLGLTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKL ARALHQCSRQDLLTCLIQLSQK-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000034761 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------QETD----------MSLDDMEMKTDDL-LEKEQIDS GG-------FGMVSLCFHRN-----HGLVILKNVYTGPKRT-----EYNAA-LLEEGKIM HRLKHNRVVKFLGFILEDG-N-----YSLVMEYMEKGNLMKVLKT--------TS---IP LSVKGRSIL-EIIEGMCYLHGEG--VIHKDLKPENILVDENFHIKIADLGVAFFKTWSK- LTKEENNRQRKI----NTAVKA-NAGTLLYMAPEHLNDV--NAK-PTDKSDVYSFAIVLW AIF-A-NKEPYE--NAICEQQIITCIGNGN-RPNVEE--IAGKCPKE-----IIDLMVRC WNGNPEDRPTF------------------------------------------------- -SEIDQEFRP----------FYLKQLG-----EKVEEDVKSLKE---------------- ------------------------------------------------------------ ---------------TYPS--PNEVVKRMQSLQVDSVPVAP------------------- ---SRTNS--EQPNSLHSSQE-LRTGSIDESM-----FAPYPENQPVEN--ESSPEAQSL QSKLQEEANYHLYGSRMDKRT--NSQFKN-----------------AAEKREEERRRRVS HDPYAAG-PAPRTTSPFYPNTFLSGKGYHLPDANSHNNLSQRPAEPSTPLPV-------- -LNNHPVFGS------RPMD-------SRTNNVLGLNPSGVSTPFKIPVPESNTG--ASM PTLPFDAIVDTDSS-------------------------------SVPCKII--NSSGIQ FGNNNYMVIDDSSL--MARNIPTNIQQESESKYQHIF----EDTTGV------LDKHLDP VRENLGKNWKKCARRLGFTESQIDEIDHDYDRDGLKEKVFQMLQKWLMREGNKGATVGKL AKALFQCQRIDLVNILIFVNQN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_anatinus_ENSOANP00000023544 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RSAD----------MSLAKMQISSDDL-LEKEQLDS GG-------FGLVSLCFHRS-----HGLVVLKNVYTGPQRT-----EYNAS-LLEEGKIM HKLNHSRVVKLLGFILEDG-N-----YSLVMEYMQKGNLMKVLKT-------DTS---IP LSVKGRTIL-EITEGMNYLHGEG--VIHKDLKPENILVDDDFHIKIADLGVAAFKTWSK- LTKEENNRQRKM----KSAPEA-AAGTLFYMAPEHLSSV--NTK-PTEKSDVYSFAIVLW AIF-A-NKEPYE--HAICEQQIYWGIIHGN-RPNVED--IRESCPKE-----IIDLMEHC WKDHPEDRPTF------------------------------------------------- -EGIHQGFSP----------FYQKHFE-----KNVETDVINLKK---------------- ------------------------------------------------------------ ---------------KYPA--PNEIVQRMHSLQIDSTPYRA------------------- ---SSTPP--DQPNSLHSSQD-LGTCYVDDAM-----FSPYPENQPVET--EAPSEEPSL QQKLQEEANYHLFGERLDKQQ--SFQNKYS----------------AAQGIEEERKRRVS HDPFAKAPGPFQTLQP------AGARAAAYHGLAGSSVGSQQSAAAGAAPSLPRRGSEP- -ASHSVSFRT------RPAK----VPAASTEYGYEPNPGPLFGLHKIPVPETNFDPLANM PTSSYPKSLASI--------------------------ED-----LGRISIT--RSSAIQ IGNCNYMMIDDKSL-QPAS---TYLNSQTQLELWAIF----ENPSSL------LDEHLHP VRENLAKQWKNCARQLGFTEAQIDEIDHDYERDGLKEKVYQMLQKWLMREGNKGATVGKL AKALYECKRIDLLNGLIRMVQS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_guttata_ENSTGUP00000002243 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSLEDIHMNTKDL-LEKKQLDA GG-------FGTISLCVHKK-----HGYVVLKKVYTGPQRT-----EYNVS-LLEEGRIM RRLQHDRVVKLLGVILEDG-N-----YSLVMEYVDRGNMMKVLQN--------IS---VP LSVRGRFVL-EITEGMLYLHEQG--FVHKDLKPENILVDRDFHIKIADLGVASFKSWSR- LTQEEIGRQKQM----KNTYQN-NAGTLFYMAPEHLRCV--NAK-PVEKSDVYSFGIVIW AIF-A-NKEPYE--NGINETQICFGIMNGN-RPDIKE--ITDKCPVE-----VIDLMKQC WDEDSEKRPTF------------------------------------------------- -AEISESYKP----------FYYENLG-----KNIEDDLKNLKK---------------- ------------------------------------------------------------ ---------------MWPE--TNELLDSMESLEIDAVPEDT------------------- ---SN--GQVDQPNSLHSSQG-PMTSEVNKAL-----FAASPENQPVESCETSFAPPDNL ERKLQHEYNYHAFGSRMDKAV--P--PVVH----------------SSEMLEEERRRRVS CDPFAKP-SPTSQLSN------MYPRAEKTGS-N------TNPYLWP-AATTPKWGNID- -----VFYRP------NPKC----PPTGKPVDASGLCSASNSIVNKPPVLESGQNVKSQT NINWNSKNSDTDTGYRDSTSFTRGTFAYHTSAPRVSP-DD-----SIKYNIS--NSSGIQ IGSYNHMKIEEQNP-HVSTYSVSMEDIYTHYEAAGVF----DNTTVL------TEKHLNL VRENLAKQWKHCARKLGFGDPEIDEIDHDYERDGLKEKVYQMLLKWVMREGTKGATVGKL AKALVGCRRLDLLRSLMQIQEE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >A_carolinensis_ENSACAP00000017421 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AN----------MSLVDIQMSSADL-LHKEQLDA GG-------FGMISLCSHKS-----YGLVILKTVYTGPQRK-----ECNNS-LLEEGKIM HKLHHDRVVKLLGVILEDG-N-----YSLVMEYLPRGNLMSVLKA--------TS---IP LPLKGRFIF-EIIEGMVYLTEQG--LVHKDLKPENILVDEDFHIKIADLGVACFKNWSR- LTKEETSRQRKI----KCSSQS-NAGTLFYMAPEHLEHI--NTV-PVEKSDVYSFGIVIW AIF-A-CKEPYE--NAVNDMQVCFCIINGE-RPLMEE--VENKCPRE-----IITLMKQS WSQKPEERLTF------------------------------------------------- -AEINIIYKP----------FYQENYE-----KYVEDDVKKIKE---------------- ------------------------------------------------------------ ---------------VYPE--PIEVVKRMQSLQVDAVAEPP------------------- ---SNS-SQTDLPSSLHSSQ------QLGNNT-----FSACPENEPVESCENASDPFVTL ERKLQDELNYHTRGSRMDRPE--NY-SATH----------------SAVAWNEKRKMKVS NDPFTKG-PAAPRAQE------ANSGSSISPS-NAFGGPYTSPWPWPLSPAGPGPENGNA TLDRKSPNGA------RPSN----FSSFGAEDMYRSHSTSPFSFYKPPVPESEIDRFPHD V----PKSLSTQTG-----------------EPP-------------RFNIF--NSTGIQ IGNYNHLEIKDPSL----PSTPPAPLLYNHKVYRDLF----ESTTLV------SETHLNI VRDNMGKHWKDCSRKLGFSDAELDEIDHDYERDGLKEKVYQMFQRWQMRQGSKGATVGKL ALALHACHRIDLLNCLVKINKE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000036419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------MSLDDIHMSTEDL-LDKQQLDA GG-------YGKIYLCFHRT-----YGYVVLKTVYTGPQRT-----ECNAS-LLEEGRIM RSLQHDRVVKLLGVILEDG-N-----YSLVMEYVHRGNMMKVLQK--------VP---VP LSVKGRFIL-EITEGMLYLHEQG--LVHKDLKPENILVDKDFHIKIADLGVASFKNWSR- LTKEETCRQKKI----KSACQN-NAGTLFYMAPEHLNDV--NVK-PVEKSDIYSFGIVIW AIF-A-NKEPYE--NCINEDHIYFGIIHGN-RPDIEE--IIEKCPKE-----IIDLMKQC WEQKAENRPTFS------------------------------------------------ -AEISENYTP----------FYYQNLE-----KNIEDDLKKIEE---------------- ------------------------------------------------------------ ---------------TWPE--SEELLQRMKSLQIDAVGVDT------------------- ---SN--GQIDQPNSLHSSQG-----QINEAL-----FAACPENQPVESCETSFTSPDNL ERKLEREYDYHAFGSRMDKPV--V--P-PY----------------TPEMRERERKQKVS HDPFAKL-PSVPHWSE------LYHKAENIGS-N------TNPWFWPKQAAIPTQGNLD- -----NFYGP------NISS----LLTGNTEDLYDPSSTSAISLSKTPVPESRPNLAAQS STSQQQKNADTDTGIKVSASFTRGTFTYYPRAPPITR-ED-----SIMYNIT--NSSGIQ IGSHNHMKIEEQNQ-HISTSSVAKDASYSYYESTGIF----DNNTVL------TKKQLSL VRENLGKQWKHCARELGFSNSVIEEIDHDYERDGLKEKVHQMLHKWIMGQGSKGATVGKI AKALFGCRKLDLLTSLMQMSEE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >X_tropicalis_ENSXETP00000024916 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TSLENIIMKSEDL-INQHKLDA GG-------CGLVSLCHHRI-----YGLVVLKTVYTGYMHT-----QSNEK-LLEEGKIM HMLKNDRVVKLLGLILENE-N-----YSLVMEYIRNGHLLTVLQQ--------VE---VP LSVKTRFIL-EIIEGMSYLHDQK--VVHKDLKPENILVDEDFHIKIADLGLATFNRWSK- LTKEQSKLQRKYMHQSTGSYKS-NAGTLIYMAPEHLRSL--NAR-PTEKSDVYSFGIVTW VIF-T-NKEPYE--NALNDEQISYCVKKSE-RPCLEE--LPEECPPE-----ALDLMQQC WDDNPDKRPLF------------------------------------------------- -KEIKEISVP----------TNSTAL--------LICPLTKMQS---------------- ------------------------------------------------------------ ---------------EFER--PNVIVERMASLQLDCVAEPP------------------- ---SLQPR--DQPLSLHSSQGFITTNQVDESL-----FGPAL-NEPIES--EDPRQDETL ERKLQNEINYHQNGSRLDNIG--SQ---SY----------------TPKSSLEERSKKVF NE-------------------------------ASGMNHIPAASGFTNSPIAGNFETP-- -FYPASHFNNWQDIYQRPDQNRGYVPVGSYGQTSLSQNSNTDWKEKNPTPETGAQ--SSH PRSQLFARDDRT---GVDICGTQGPWVYYKLHLKVKRMDN-----GLNVSIS--NSNSIQ IGNHNTLSVISNRP-KPRPEYITR-TSNSSVEDLAAF----ECQTIV------NDNHLQL LRENLSKKWKLFARHLGFREPEIDEIDHDYERDGLQEKVHQTLHKWKMREGSKNATVGKV AKALFLLGESELMHALMKMEEC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000014604 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MS----------TSVSPSLMKSADL-IKKEPLDY GG-------FGEVYLCYHKT-----LGHVVLKTVYTGPPRSG----RQKQS-LLEEGSLM SRLNHQRVVKLLGVILEDG-D-----YSLVMELIPKGNLLTMLET--------VT---VP ISVKGRIIL-EILEGMVYLTKNQ--VIHKDLKPENILVDKNFHIKIADLGLATSEVWSK- LTKEESRRQSRL---GKKTSAH-AAGTLCYMAPEHLKSI--HTR-SSEKSDVYSFAIVLW VIL-T-GREPYE--NARSEDQICHCVCQGE-RPDEAL--IPPNTPTD-----ITDLMKSC WHQDPLQRPSF------------------------------------------------- -TDCYNRFLP----------FYKEKLA-----ANVKADLENLMK---------------- ------------------------------------------------------------ ---------------LYEG--PEELVEKLKLLNTNALIPE-------------------- ---DPSLCSRDSPTPLRSSDI----GPVEASIEDLSFRSCED--SVLEADATP--SCPNL ELKLEQEYNYHKFGSRI------VDQSDGSMWSPAQ----------QPASSTDASSQMSS VKSWTK---PSAPSTE----------EELYPRAAASFDSLHRP-ELRSQFSVPQSDHERL RPHAHLPWNR----------------------------VKSCPEGANHVAESLIDTNSNL RFNSPVTYPASDS--------------------------------AFPVSIS--NASAIQ IGSYNTMNLRISDSSPYSSFSTTGSTTSRYKELLLMY----AESHTV------TESHLEL VRQNVGANWKQVARKLGLSEIDVETIEHDYDRDGLTEKVHQMLERWKMREGLMGITVGKL CQALEGCIKPNALLHMLRQLQDSAAAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000006568 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T----------APQLSLHMRSTDF-IKKEPLDY GG-------FGDVYLCLHVT-----LGQVVMKTMYTGPLRNE----DRKKL-LIEEGSIM ASLNHERVVKLLGVIMEDG-D-----CSLVMELIPRGNLLVMLET--------VS---VP LSVKGRIVL-EILEAMLYFSEKD--IIHKDIKPENILVDKDFHIKIADLGLAISQSWSK- LTKEESRRRSHK---GQSVGAR-GAGTLSYMAPEHLESI--HAA-STEKSDVYSFGIVVW VVL-T-GVEPYA--NARSEDQICQCVRNGD-RPAESC--IPADTPQQ-----LVHLMRWC WHQKPQDRPTF------------------------------------------------- -KEGYNYFHP----------FYMEKLA-----PCVEKDLQKLRT---------------- ------------------------------------------------------------ ---------------MYEG--PEDLVKKMKSLSVSQDCSLGEMNRLRSSTIPSKVAVSAG LQNEIRSEISNCPASLVSSES--VSVPVEASVEDLHGIQAQP--QHIQSDA-AVSSPLPL EEKLNQELQYHERGNYGGGTQ--FDIANGNFYSTSNPFLPNLHPDPTVTHLGQDRLSSSS VHSFTRA-EPVHPIGQ--DERWYPPSGDLSLSMQSSAPSKPHLATSVSMPFIPQPN---- ---------R----------------------------ENHWP----------------- ------------------------------------------------LIIQ--NANGIQ IGSNNQMNFK------SLSASAGDSCSFSIKQGIQKYAFVCSGGHAV------TEKHLDL LRDNIGAKWKRCARRLGLTDVEIENIEYKSHRDGLSEMVHQMLDCWKMKEGSYGCTIGKL LEALEGNIKVDLIQKILDTCNS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000021561 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MAS----------APQTSLHMRPTDL-IKREPLDY GG-------FGEVYLCYHAT-----LGQVVLKTLYTGPLRSE----ESKRS-LLEEGSIM ASLNHERVVKLLGVVMEDR-D-----CSLVLELLPRGNLLVMLET--------VK---VP ISIKGRIIL-EVLEGMIYLTEKR--VIHKDIKPENILVDKDFHIKIADLGLATCQTWSK- LTKEESRRKSRS---GQTSGAR-GAGTLSYMAPEHLRSI--HTP-STEKSDVYSFGIVVW VIL-T-GEEPYA--NARSEDQISRCVRDGD-RPAEDL--IPEDTPSE-----VVQLMKRC WSDNPEERPSF------------------------------------------------- -KEAYDIFCP----------FYAKNLE-----PHIENDLQDLKE---------------- ------------------------------------------------------------ ---------------NYEG--PMTLVEKMKLLSVRHDSFL-------------------- ---TNEQVPLDSPAPLVSSDT-NVSVPVEASIEDLHVINYKPLGDSIQADAR---QPSEL EEKLGRELYYHIHGSYNSDMH--PPAASSYYNNAPNHLLQN-HVSPLDQSGRPPARDTSS VHSWTK--EPVQPTGS--DQLFFPLNPVNPS--SMASPTPTHLNASASMSSLQQVNQ--- --HLHPHLDR----------------------------QQSWP--VYPVPDTFVPDMNAS GCGTPSKGFQPQE--------------------------------PGPLFIQ--NASGIQ IGNNNTLSIRAFDN-PVSSQCVSGSSLSPIQEGLLKF----LEDQAV------TEEHLYL LTENIGNSWKRCARRLGLKDVEIQTIEHDYYRDGLPEMVHQMLERWKMKEGSIGCTVGKL CRALDGNIKVDVIQKILDMCGL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000017178 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AMAT----------APPSALHVRSADL-IKKEPLDY GS-------FGEVYLCYHVT-----LGQVVLKTMYTGPLSNA----RSQKS-LLEEGNVM ASLTHDRVVKLLGVIMEDR-D-----CSLVMELIPRGNLSSLLET--------VA---VP LSIKGRFIS-EILEGMVYLTERQ--VIHKDIKPGNILVDKDFHIKIADFGLATSRTWSK- LTKEESRKRSLM---GRSAEVR-GAGTLSYMAPEHLQSV--HTA-STEKSDVYSFAIVLW VIL-T-GEEPYA--NARSEEQISQCVQKGE-RPEESL--IPGDALEE-----MIALMRRC WGHNPLQRPTF------------------------------------------------- -KEGYDFFLP----------VYAERLE-----PHVEDDVLEFRK---------------- ------------------------------------------------------------ ---------------IYEG--PEELIEKMKSLSMTQDC---------------------- -------LSADCPAPLLSSDG-SVPEPVEASIEDLHGLQHQPPVDSLQTDAKAGETPSDL EEKLAREFQYHKHGSYYREDQ--QGGARCLPHSHSHPFLPN------------------- --------------HE--EACYRPTAGHGSQ--NSSPPSWYTMSTSAGSPSLSQFNQQ-- --DPLSHYDR----------------------------QRSCP--AYPVSETSAPAFGPG RLLTPNKGFSQQ---------------------------DSGTDIPTRVFVQITNASGIQ IGSNNTMHIRSYDSISSLESGPSDPASSTITERIVKC-----EERAV------TEEHLDL VRKNVGAKWKRLARRLDLTTVEIETIEHDCDRDGLPEMVHQMLEQWKMKNGRMGCTIGKL CRALEGQVKVDVIHSICDTCCSSSSAR--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000029776 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MAA----------APQLSLHMRSTDL-IRKEPLDY GG-------FGDVYLCLHVT-----LGQVVMKTIYTGPLHSK----EKKKL-LIDEGSIM ASLNHERVVKLLGVILEDR-D-----CSLVMELIPRGNLLVMLQT--------VS---VP LSVKGRVTL-EILEAMVYLSEND--IIHKDIKPENILVDQDFHIKIADLGLAVSQAWSK- LTKEESRRKSR-----QTTGER-GAGTLSYMAPEHLESI--HAA-SMEKSDVYSFAIVLW VIL-A-GVEPYA--NARSEDQICQCVRKGD-RPAEDL--IPKDTPGK-----LIHLMKWS WQQDPRCRPTF------------------------------------------------- -KEAYDFLFP----------FYMETLA-----PCVEEDLLKLRM---------------- ------------------------------------------------------------ ---------------MYEG--PEYLVEKMKSLSLSCSLGD-------------------- ---ELQLKLADCPAPLVSSDS--VSVPVEASIEDLHDIQSSQ--RYIQSDARAASVPQAL EEKLNQELQYHQGGNYNSATQ--ADAAKGYLHSSTNPFLPNL---PDLTTSGQDRPYTSS VQSFTKA-APVHPTSQ--EDH---PSADPSQSMNSTVPSKPHLSSSVTMPLLPQLNQE-- --HPHSLYSR----------------------------QQSWP--TFPATDTATREYSLG SLLAPSKSRLQD---------------------------------PGSLFIQ--NASGIQ IGSNNKMSIKSCPS-WSLPPSSSDSFPFYVKEGVQKY-----GDHAV------TEEHLDL LKENIGAKWKQIARRLGLTDTEIETIEHDFHRDGLTEMVHQMLERWKMKEGSIGYTIGKL LRALDGNINVELKCHRLNQLHLSSMTQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000006806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CSKLWAS----------GAPA-SLVPIKEL-ENPKFIGQ GG-------FGTVFQAQHRS-----WGHDVAVKI------------VNREA-ISREVKAM ANLRNPYILLLLGVTEKLE-WDYVSGPALVTAFMENGSLAGLLQP-------QCP---RP WPLCCRLLL-ELVLGMCYLHSQNPVLLHRDLKPSNVLLDSELHIQLADFGLSTFQGGSR- --SGSWSGE--------------PGGTLAYLAPELLADV--NQK-ASKASDVYSFGILMW ALL-A-GREAET---VTQTSVVQEAVCERQNRPPLTE--LPPPGPETAGLEELKELMQQC WSQEPKDRPSF------------------------------------------------- -QECQPKTKN----------VFHLVKD------KTDDAVSRVKK---------------- -----------------------FMSNHRD------------------------------ ------------------------------------------------------------ -----------------SNRML----SAPEPG-----PGRTEMDGPGGTTGS----HDSM VSEMLGNLNLEGSPNSV------PEKC-----TNRPER----------IRAQGRQVQRGW PAGT-SD---------------STAQPPQTPENAPFRSQI--PTSAWTPGPRPQGNQGAE RHSAHQPPRA----------------------------PGTDPTPGPPSIT--------- --------------------------------------------------VV--DCQGVQ IGNNNYLYIQGRT---TSSTQHPALWGMGWGLTAHPP----QVGSQE----GPPQEPQVW SGPQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000002206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GEGRGRW----------ALGLLRTFDAGEF-AGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERTE-LLEEAKKM EMAKFRYILPVYGICQEP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIVH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGMSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFS--DEKNILHIMMKVVKGH-RPELPP--ICRPRPRA--CASLIGLMQRC WHADPQVRPTF------------------------------------------------- -QEITSETED----------LCEKPDE-----EVKDLA----HE---------------- -----------------------PGEKSSPEP-RSEARPESSRLKRA-SAPPFDNDCSLS EL-------------LSQL--DSGISQTLEGPEELSRSS--------------------- SECKLPSSSSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREASTGDLGPTDIQ KKKLVDAIVSGDTNKLMKILQ--PQDV-----DLVLDS-SASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNKKGSTPLHMAVERRGRGIVELLLARK-TSVNAKDE DQWTALHFAA----------------------------QNGDEASTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RTLLRR GVDVGLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLSSDINICSLQAQTPLHVAAETGHTSTARLLLHRGAGKEALTSEG YTALHLAARNGHLATVKLLIEEKADVLARGPLNQTALHLAAARGHSEVVEELV--SADLI DL-----SDEQGLSALHLAAQGRHSQTVEILLKHGAH----------------------- -----------------INLQSLKFQGGQ--------SSTATLLRRSKT----------- ----------------- >M_musculus_ENSMUSP00000019386 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GEGRGRW----------ALGLLRTFDAGEF-AGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICQEP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIVH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGMSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMMKVVKGH-RPELPP--ICRPRPRA--CASLIGLMQRC WHADPQVRPTF------------------------------------------------- -QEITSETED----------LCEKPDE-----EVKDLA----HE---------------- -----------------------PGEKSSLES-KSEARPESSRLKRA-SAPPFDNDCSLS EL-------------LSQL--DSGISQTLEGPEELSRSS--------------------- SECKLPSSSSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREASTGDLGPTDIQ KKKLVDAIISGDTSRLMKILQ--PQDV-----DLVLDS-SASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRKGSTPLHMAVERKGRGIVELLLARK-TSVNAKDE DQWTALHFAA----------------------------QNGDEASTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RTLLRR GVDVGLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLCSDVNICSLQAQTPLHVAAETGHTSTARLLLHRGAGKEALTSEG YTALHLAAQNGHLATVKLLIEEKADVMARGPLNQTALHLAAARGHSEVVEELV--SADLI DL-----SDEQGLSALHLAAQGRHSQTVETLLKHGAH----------------------- -----------------INLQSLKFQGGQ--------SSAATLLRRSKT----------- ----------------- >A_carolinensis_ENSACAP00000010082 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LPTISSNKL-PDLRFLGR GA-------YGTVSSARHAD-----WRVPVAVKG---L--QGSLLESEKAN-LLKEAEIL HQARFSYILPILGICNEPE-F-----LGIITEYMPNGSLNQLLHG-------KNVYPDIA WSLRFRILY-EIALGVNYLHNMTPPLLHHDLKTQNILLDSDYHVKIADFGLSKWRMVSM- --SLSRSEKSMP-----------EGGTIVYMPPEDYDGR--QKTRASVKHDIYSYAIIMW EVM-S-RKQPFE--DVINPLQIMYSVSQGR-RPDTSEEYLPFDIPHR---GLMLSLIESG WAQNPDERPSF------------------------------------------------- -SKCLIELEP----------VVRTFDE-----IPTLQAVIQLKK---------------- -----------------------AKVTRNS----VAGISTSNNQ--SVSLNIPLDS-SLQ EV-I-NSV---SVLEVRIG--GGGGNKSYTSTCDTVSHLGGV------------------ ERCD---FIHAVQPP--QTRKL----ATQSII-----PASRG----------------RA GRR--------AGLTSLSALS--PSMV-----EVGAQN-KFAIAHQWIQNKREEIVNQM- -----------------------------------TEACLNQSLDALLARD----LIMRE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------SQGEEVA--RIIVQK LKDN-----------------------RQLGLQPYPN----IP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000011422 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------VSDSPPG----------TMGLLRTFDCSEF-GSWEKIGS GG-------FGQVYKVRHVR-----WKTWLAIKCPPCLHVDD----KERSE-LLEEAKKM EAAKFRYILPVYGICGDP--------QGLVMEYMEMGSLENLLAT-------EL----LP WELRFRIIH-ETAVGMNFLHCMKPPLLHLDLKPANILLDAHYHVKISDFGLARWNGLSR- --A-DDISRDG------------FCGTIAYLPPESIIEK--DRV-SDPKHDVYSFSIVIW GIL-T-QKKPYQ--GENNILQIMVKVVKGV-RPDLGS--IPRCRPPV--CSGFLSLMQRC WATDPNARPSF------------------------------------------------- -QEITSEAEE----------LYFKPQE-----EPKNTTE---SA---------------- -----------------------PG-PTPHKA-TT---SDQKGMRPK-SAMLPEKDCSLS EL-------------LTQV--DSWISRSFDRLKENSCHS--------------------- KE------STSKRLS--GISFA----DSAFSS-----QDSITLSFEKENTF-D--SSEVQ KRKLCDAIRTKDTAKLMKILQ--PQDV-----DLLLDG-GDSLLHHAVTLANEEAVKFLL LNNANPN---------------LANARGSTVLHVATERHLKPTVELLLGRRSTNVNAKDE DQYTALHWAA----------------------------QNGDEAIARLLLDRGAAINETD GRGRTPAHIACQ---------------------------------HGQENVI--RVLLSR GADVQIRGKDDWTALHLAAWQGHLGIVKLLVKQAGAD----VDGQTA-----DGRTPLHL ASQRGQYRVARILIELGANVHMTSVGCTT-LHVAAETGHTSTSRLLVKHRADVHAQSALG LTPLHLASQRGHLATVKMLIEEGADPCRSGPGPCTPFQLAAENGHGEVLNELL------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_anatinus_ENSOANP00000010284 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------K--- ---------------------ESSGSPG----------EMGLLRAFDSAEF-VSWEKIGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPGLHVDD----KDRVE-LLEEAKKM EMAKFRYILPVYGICRDP--------VGLVMEYMETGSLEKLLAS-------EP----LP WELRFRIIH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCSGLSH- --S-HDLSMDG------------LCGTIAYLPPERIKEK--NRF-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VSKSRPRS--CNNLIRLMQKC WRDNPRERPTFQGDNIKEIQVGFKYSEIIIISQLNWGILALK--KQLNTTVTANVTSPDL PQEITSETED----------LCEKPDD-----EIKET-----QE---------------- -----------------------LDIKNPHEP-KTEEMPALPAPKRA-SAPAFDADYSLS EL-------------LSQL--DSETSQTMEGPDELSRSS--------------------- SESKLVSTSSGKRLS--GVSSV----DSAFSS-----RGSLSLSFERENSVSDISTTDLH KRKLAEAITSGDTGKLMKILQ--PQDV-----DLVLDG-QSSLLHLAVEAGQEECVKWLL LNNANPN---------------LTNKRGSTPLHVAIEKKVRSVVELILARK-INVNAKDE DQWTALHFAA----------------------------QNGDECSTRLLLEKNASPSEVD FEGRTPMHVACQ---------------------------------HGQENIV--RILLRR GVDVSPQGKDDWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHM AAQRGHYRVARILIDLRSDVNVRNRLLQTPLHVAAETGHTSTSRLLLNRGAEKEALTVEG CTALHLASRNGHLATAKLLLEEKADVLGAGPLSRTALHLAAANGHAGVVEELL--GAVAI DA-----ADREGLTALHLAVRGGHAETMEVLLKHGAR----------------------- -----------------INLQSLGAQAPPLLPGN---SPVATLLRRRNT----------- ----------------- >X_tropicalis_ENSXETP00000000115 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MD--- ---------------------KEGASPW----------DMGLLRTFDSREF-CGWEKVGS GG-------FGQVYKVKHIS-----WKTWLAIKCPPSLHVDE----KERIE-LVEEAKKM EMAKFRCILPVYGICSDP--------VGLVMEYMETGSLEKLLAS-------EC----LP WDLRFRIIH-ETAVGMNFLHCMNPPLLHLDLKPANILLDGHYHVKISDFGLAKWNGLSN- --S-HELSLDG------------ICGTIAYLPPERFKEK--NRS-FDTKHDVYSFAIVIW GIL-A-QRKPFA--EEKNILHIMVKVGGGL-RPDLSQ--IPRVRPQQ--CQGMIQLMKEC WHDKPDKRPTF------------------------------------------------- -QEITSETEH----------LCTKHED-----ETSCVQA---QE---------------- -----------------------LHGKGTLDA-EAENVGSQAECKRS-PTPAFDKDYSLS EL-------------LSQL--DSGISQTMEGPGCLSHSV--------------------- SEPQL--ASSDKRLS--GVSSV----DSAFSS-----RGSLSLSFEKDCSVLDISANDIQ KKKLIDAIAGGDTAKLMKILQ--PQDV-----DLVLEG-RSSLLHLAVENGQEECAKLLL LYNASPN---------------MTNLKGSTPLHIAADKKLKNIVELLLGKK-INVNAKDE DHFTALHFSA----------------------------QNGDECITRMLLEKSASLNEVD IKGRTPLHVACQ---------------------------------HGQENIV--RVFLRR EADLTFKGQDNWLALHYAAWQGHLNIVRLLAKQPGAN----INAQTS-----DGRTPLHL AAQRGHYRVARILVDLRCDVNIPSILMKTPLHVAAETGHTSTARFLLSRGASVNAVTSEG FTALDLASNLGHYSAVKLLMDEQSNVKLKDSTEEDSFS-SIESGRSL------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000009583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------DSADSLA----------ISSSLPTIPYHKL-ADLRFLSR GA-------SGTVSSARHAD-----WRIQVAVKH---LHFQTPLQESDISD-ILREAKIL HKARFSYILPILGICYEPE-F-----LGIVTEYMSSGSLNQLLHR-------KNDYPDIA WALRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRQMSL- --SQSKSSTSNP-----------EGGTIIYMPPENYDHS--QNSRASIKHDIYSFAIIMW EVL-S-RKQPFE--EVVNPLLIMYRVSKGN-RPDTDEENLPLDIPHR---TQMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------IVRTFED-----ITILEAVLQLKK---------------- -----------------------TKVNSNNL--KIIPLSSKKTM--EYPLNIPVNN-GPQ EE-S-CRT---PLTIHS----DPGIARSITTPQDNFFSSEQN------------------ QE-----HSTLPHFS--LNHSW----DDNISS-----VQRAK----------------FC NHK--------ATCSS---VH--PLTL-----EGNSESQGNDVAQQWIQSKREDIVHQM- -----------------------------------TEACLNQCLDALLSKD----LLMKE DYEL---IST----------------------------KPTRTSKVRQMLD--------- ---------TSD---------------------------------IQGEEFA--KIIVQK LKDN-----------------------KQLGLQPYPE----VPIISR-------ITSLNL FQNKS--F---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000025962 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MA--- ---------------------RESGSPW----------AMGLLKTFEESEF-GSWEKIGS GG-------FGQVYKVRHLH-----WKTWLAIKCSPSLHVDE----KERME-LLEEARKM EMAKFRYILPVYGICKEP--------VGLVMEYMETGSLEKLLAS-------EP----LP WELRFRIIH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LCGTIAYLPPERIKEK--NRC-FDTKHDVYSFSIVIW GVL-T-QKKPFA--EENNILHIMVKVVKGH-RPELPA--VSKSRPHS--CNNLIKLMQKC WQDDPGERPTF------------------------------------------------- -QEITSVTET----------LCEKPED-----ETKEMVA---ED---------------- -----------------------LDTKSSPKQ-RSEGMSALSQPKQE-PVLASDKDYSLS EL-------------LSQL--DSGISQTMEGPEDLSRSS--------------------- SESKL--AASDKRLS--GVSSV----DSAFSS-----RGSLSLSFERESSGNDIGTTDIQ KRKLTEAILAGDTSKLMKILQ--PQDV-----DIVLDG-NSSLLHLAVEAGQEECVKWLL LYNANPN---------------LTNKKGSTPLHIAIEKKIKSIVELLMARK-INVNAKDE DQWTALHFAA----------------------------QNGDDFSTKMLLDKNASLNEVD FEGRAPIHIACQ---------------------------------YGQENIV--RILLRR GVNVNIKGKDDWVPLHYAAWQGHLPIVKLLAKQPGAN----VNVQTV-----DGRTSLHL AAQRGHYRVARLLIDLESDVNVLNALSQTALHIAAETGHTSTSRLLLKHGADIEAVTVEG CTALHLASRSGHLATTKLLTDEGANVLARGPLNRTALHLAAENGHSEVVEELV--SSGNI NV-----SDDEGLTAFHLAARGGHTKTVEVLLKHGAL----------------------- -----------------TDLQRPTFQ---------------TLLRLTQQ----------- ----------------- >P_troglodytes_ENSPTRP00000023968 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GDGGTPW----------ALGLLRTFDAGEF-TGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VCRARPRA--CSHLIRLMQRC WQGDPRVRPTFQGNGMNGELIRQVLAALLPVTG-RWRSPGEGFCLESEVIIRVTCPLSSP -QEITSETED----------LCEKPDD-----EVKETA----HD---------------- -----------------------LDVKSPPEP-RSEVVPVSARLKRA-SAPTFDNDYSLS EL-------------LSQL--DSGVSQAVEGPEELSRSS--------------------- SESKLPSSGSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTSDLGTTDVQ KKKLVDAIVSGDTSKLMKILQ--PQDV-----DLALDS-GASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRRGSTPLHMAVERRVRGVVELLLARK-ISVNAKDE DQWTALHFAA----------------------------QNGDESSTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RILLRR GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVT----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDG YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADVI DL-----FDEQGLSALHLAAQGRHAQTVETLLRHGAH----------------------- -----------------INLQSLKFQGGH--------GPAATLLRRSKT----------- ----------------- >M_mulatta_ENSMMUP00000023719 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GDGGTPW----------ALGLLRTFDAGEF-TGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VCRARPRA--CSHLIRLMQRC WQGDPRVRPTFQGNGMNGELLRQVLAALLPATG-RWGFPGEGFCFESEVIIRVTCPLSSP -QEITSETED----------LCEKPDD-----EVKETT----HD---------------- -----------------------LDVKSPPEP-RSEVVPVSARLKRA-SAPTFDNDYSLS EL-------------LSQL--DSGVSQAVEGPEELSRSS--------------------- SESKLPSSGSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTSDLGTTDVQ KKKLMDAIVSGDTSKLMKILQ--PQDV-----DLALDG-GASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRRGSTPLHMAVERKVRGVVELLLARK-ISVNAKDE DQWTALHFAA----------------------------QNGDESSTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RILLRR GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDG YTALHLAARNGHLATVKLLIEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--STDVI DL-----FDEQGLSALHLAAQGRHAQTVETLLRHGAH----------------------- -----------------INLQSLKFQGGH--------GPTATLLQRSKT----------- ----------------- >H_sapiens_ENSP00000330161 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GDGGTPW----------ALALLRTFDAGEF-TGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VCRARPRA--CSHLIRLMQRC WQGDPRVRPTFQGNGLNGELIRQVLAALLPVTG-RWRSPGEGFRLESEVIIRVTCPLSSP -QEITSETED----------LCEKPDD-----EVKETA----HD---------------- -----------------------LDVKSPPEP-RSEVVP--ARLKRA-SAPTFDNDYSLS EL-------------LSQL--DSGVSQAVEGPEELSRSS--------------------- SESKLPSSGSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTSDLGTTDVQ KKKLVDAIVSGDTSKLMKILQ--PQDV-----DLALDS-GASLLHLAVEAGQEECAKWLL LNNANPN---------------LSNRRGSTPLHMAVERRVRGVVELLLARK-ISVNAKDE DQWTALHFAA----------------------------QNGDESSTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RILLRR GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADVI DL-----FDEQGLSALHLAAQGRHAQTVETLLRHGAH----------------------- -----------------INLQSLKFQGGH--------GPAATLLRRSKT----------- ----------------- >G_gallus_ENSGALP00000025574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MSGG- A--------------------GGDRAGA----------ISSALPAIPSSKL-PDLRFLSR GA-------YGTVSAARHAD-----WRVPVALKC---L--QGPLLDSDRNH-LLKEAEIL HKARFSYILPILGICNEPD-F-----LGIVTEYMANGSLNQLLHG-------KDMYPDIA WCLRYRILY-EIALGVNYLHNMNPPLLHHDLKTQNILLDDEFHVKIADFGMSKWRVISM- --SQSRSETSLP-----------EGGTIVYMPPEDYNPS--QKTRASVKHDIYSFAIIIW EVM-S-RKHPFE--EVINPLQIMYSVSQGH-RLDLSETSLSMDIPHR---ALVIRLIESG WAQNPDERPSF------------------------------------------------- -LKCLIDLEP----------VLRTFDE-----IAILEAVILLKR---------------- -----------------------SKSQYES---PCIHKSGKKAIVEKTSLNIPLN---PQ EE-T-SASIHCDALPLRSV--SPDISRLKSLPQCNILSSGTAGEKAEKTIGFTAVKQSI- KKCA-DGDSGGLNSL--SCQSA----DENLSI-----TQSAKPFVHPYSYLPSSDKN-IS VAS--------NSSSCMLQTS--PISS-----DFVLETIQQNVAHQWIQSKREEIIDQM- -----------------------------------TEACLNQSLDALLSRF----LLMKE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TSD---------------------------------SQGEEFA--RIIVQK LKDN-----------------------KQLGLQPYPD----IVPNSL-------RLHL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_guttata_ENSTGUP00000012150 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MSGGD G--------------------GGGRPGA----------LSCGLPSIPSSKL-PDLRFISR GA-------YGTVSAARHAD-----WRVPVALKC---L--QGPLLDSDRNH-LLKEAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMTNGSLNQLLHG-------KDVYPHIP WCLRFRILY-EIALGVNYLHNMNPPLLHHDLKTQNILLDDEFHIKIADFGMSKWRVVSM- --SQSRSESSLP-----------EGGTIIYMPPEDYNPS--QKTRASVKHDIYSYAVIIW EVM-S-RKQPFE--EVINPLQIMYSVSQGQ-RLDLSEGSLSTDIPHR---GLIIRLMESG WAQNPDERPSF------------------------------------------------- -LKCLIDLEP----------VLRTFDE-----IAMLEAVILLKR---------------- -----------------------SKSLYDS---QSIYKSGKKANVEQISLNIPLD---PE KP-AYCSSIQCDALPLRSI--SPDTSKFKSIPQCNILSSGEMFLTFRKLGLFMSEKSLFC KLCALDGNSGSLHSL--SSHSM----DENLSV-----TQSARLLVHPYSAVLSTDKRVVS DAS--------SSASHVLRSS--PIPS-----DFVLETIQQNVAHQWIQSKREEIIDQM- -----------------------------------TEACLNQSLDALLSRF----LLMKE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TSD---------------------------------SQGEEFA--RIIVQK LKDN-----------------------KQLGLQPYPD----IVPNSQ-------RLHL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000026689 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MD--- ---------------------VPDSPHG----------NMGLLRTFDSPEF-GSWEKIGS GG-------FGQVYKVRHIQ-----WKTWLAIKCPPCLHMDD----KERSE-LLEEAKKM EAAKFRYILPVYGICGDP--------QGLVMEYMETGSLETLLAT-------EQ----LP WELRFRIIH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLARWNGLSR- --A-DDISRDG------------FCGTIAYLPPESIIEK--DRV-SDTKHDVYSFSIVIW GIL-T-QKKPYQ--GENNILQIMVRVVRGL-RPDLAA--VPRCRPSA--CTGFLSLMQRC WTSNPDARPSF------------------------------------------------- -QEITSEAEE----------LCSKPQE-----EPKTLTV---LT---------------- -----------------------SE-PTSPNALTSDQVKDNK--RPK-SAMLPEKDYSLS EL-------------LSQV--DSGISRSFDRVKDK---S--------------------- KE------DTCKRLS--GISSA----DSAFSS-----QDSITLSFEKDNTC-D--SAEAQ RRKLCEAIRTKDTAKLMKILQ--PQDV-----DLLLDG-GGSLLHHAIALANEEAVKFLL LNNANPN---------------LANARGSTPLHLATERHLKSMAELLLGRRCTNVNA-DE DQYTALHWAA----------------------------QNGDEAITRLLLDRGAAINETD GQGRTPAHVACQ---------------------------------HGQENVI--RVLLSR GADVHIRGKDDWTALHLASWQGHLGIVKLLVKQAGAD----VDGQTT-----EGRTPLHL ASQRGQYRVARILIELGADVHMTSTGLNAPLHVAAETGHTSTSRLLIKHQAEIHGQNAHG LTPLHLASQRGHLATVKMLIEEGADPYRSDQALRRPCHLAAENGHCEVLRELLLHCPDGG TL-----LDEQGLSPLHLALQGGYSNIITMLLPHDCQDM-VTKTSMQPAAE--------- RPAVPETLPGAPPEAVPLQRKVVILKLTER----CPQSST-ERCTSAPC----------- ----------------- >O_latipes_ENSORLP00000015653 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MD--- ---------------------VPESPQG----------NMGLLRTFDFTEF-SSWEKIGS GG-------FGQVYKVRHVK-----WKTWLAIKCPPCLHVDE----KERSE-LLEEAKKM EAAKFRYILPVYGICDDP--------HGLVMEYMEIGSLETLLAT-------SP----LP WELRFRIIH-ETAVGMNFLHCMDPPLLHLDLKPANILLDAHYHVKISDFGLARWNGLSR- --AEDDISREG------------FCGTIAYLPPERIIEK--LRV-SDTKHDVYSFAIVIW GVL-T-QKKPYQ--GENNILQIMVKVVKGV-RPDLGA--VPRCRPNT--CDGFLSLMQRC WATNPDDRPSF------------------------------------------------- -QEITSEAEE----------LCSKPQE-----EPKTPTLRSSSE---------------- -----------------------PE-PMSPNSSTSNEGKDAKPVRPK-SAMLPEKDDSLS KL-------------LSQV--DSGISRSFDRVKEDSCQS--------------------- RE------STSKRLS--AISSA----DSAFSS-----QDSITLSFEKESTIED--SAEVQ KRKLCEAIRTKDTAKLMKILQ--PQDV-----DLVLDD-GGSLLHHAIALDNEEAVKFLL LNNANPN---------------LPNTRGSTPLHLATEKHQKPLAELLLGRRSMNVNAKDE DQFTALHWAA----------------------------QNGDEAIARLLLDRGAAINETD GQGRTPAHVACQ---------------------------------HGQENVI--RVLLSR GADVQIKGKDNWTALHFAAWQGHLGIVKLLVKQAGAD----VDGQTS-----DGRTSLHL ASQRGQYRVARILIELGASVHLTSVGLNTPLHVAAETGHTSTSRLLIKHKADMHAQNTQG LTPLHLACQRGHLATVKMLIAEGADPSRPSQTLCTPCHLAAGSGHCEVLKELLLHCPDAG SV-----TDEEGLSPLHLAVGAGHSNVIKMLLPQE--------VCQQPAAE--------- EP--------RPPESKQLQRKVVILKLTEHSNKDCPQPPA-SQCASAPC----------- ----------------- >M_domestica_ENSMODP00000026215 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------KESSSPW----------EMGLLRTFDSGEF-ISWEKIGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----KERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-QDLSIDG------------LFGTIAYLPPERIKEK--SRF-FDIKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RLELPP--ISKSRPRA--CNNLIRLMQKC WQDDPQSRPSFQGNAPFLALPSQDYCLTAPLSS-RWPGLAAKFLRTLEAICSVNMLSLSF -KEITAETED----------LCEKPDD-----EIKETA----QE---------------- -----------------------LDIKNPQEP-KAEATSIPAQFKGV-STPTFDKDYSLS EL-------------LSQL--DSGISQTIKHSEELSRSS--------------------- SESKLASSSSGKRLS--GVSSV----DSAFSS-----RGSLSLSFERENSTSDIGTTDIQ KRKLAEAIMSGDTSKLMKILQ--PQDV-----DLILDG-NSSLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRKGSTPLHVAIEKRVKNVIDLILARK-INVNAKDE DQWTALHFAA----------------------------QNGDESSLRLLLDKNASFNEVD FEGRTPMHIACQ---------------------------------HGQENIV--RILLRR GVDVSLQGKDDWMPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLQSDVNIRNLFLQTPLHIAAETGHTSTSRLLLNRGAEKEAMTAEG YTALHLASQNGHLATAKLLMEEKADLFVGGPLNQTALHLAAAHGHSEVVEELL--TPDNI NL-----FDDEGCTALHLAARGRHAKTVEVLLKHGAH----------------------- -----------------INFQGLKFQSSQQLVEQRGTSPIATLLRRSKT----------- ----------------- >X_tropicalis_ENSXETP00000025515 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------E--- ---------------------MAEEIDE----------RIGNLIQFKKEDFENDWIPVAL GG-------FGQVYKVRHKK-----WWTVYAVKCSTAIVGDSELLSTTYNS-LLEEASKM EKIKFNYIVQIYGICSNP--------IGIVMEFMENGSLEKMLPT-------HT----LS WQLKFRFIH-EIALGMNFLHSMSPPLLHLDLKPGNILLDSHLHVKISDFGLSKWKENST- --RNEYIQRSA------------IKGTLSYIPPEMFLQS--SRL-PGTKYDVYSYSIVIW ELL-A-QKKPYA--G-ASMLNIIVKVAAGK-RPPIHD--ISEERPVE--CQQMIDLMQRC WNQNAKKRPNF------------------------------------------------- -SDIVMESHM----------LLCLVQS-----PLPEPET---NT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------DNTGEDILKSSSIMLF----S---------------------------ENTNFI AKKI-------ETQNLLRNIM--LEDQ-----TWVDDN-DFSLLHVAVAQGNLEKVNHFL SLNLNIN---------------SKSISGFTPLILAVQKKLPDICMCLIENG-ADVNITDE DMWSPLHFAA----------------------------QGGDDRIVRLLLDHSANVDSKE RDDWTALHLAAQ---------------------------------NGYENVV--RVLFTR HTNPNSQEVNGKTALHLATYFGHYKLVKLLISQ-GAN----VNSIQN-----DQRTALHI AADKGYFRVAQHLIQKGANLNFPDQSNYTALHMAAVKGNSMICKLLIKHGANADAKSFQD WTPLHLATYKGHTEIINLLKDGGSNIDSEGDLKWTPLHLAVRYSEELVVSHLLTLGADPE I------AEMSGWTALHLAVQRGAFCSVINLIEHKADVNAKNAFGWTPLHV--------- ----------AVLNSNVSIIKTLLLANAKLSIEDNSGCTPLQLAARNRKHDVVALLEGRD ----------------- >C_familiaris_ENSCAFP00000020477 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MAAGLEQ----------RLGSPAVFTRDDFDGHWHRLAS GG-------FGQVFQVRHRL-----WGTEYAVKCCPCGQREA--TSSDVDC-LIEEAAKM EKIKFQHIVSIYGVCRQP--------LGIVMEFMTNGSLEKMLPT-------HS----LS WQLKFRIIH-ETSLAMNFLHSIKPPLLHLDLKPSNILLDNNMHVKISDFGLSKWMEQST- --GMQCIQRSA------------LRGTLSYIPPEMFLES--NKP-PGRKYDVYSFAIIIW ELL-T-QKKPYS--G-FNMVTIVVRVAAGM-RPSLQP--VSDEWPGE--AQQMVNLMRRC WDQDPKKRPCF------------------------------------------------- -PDITVETDM----------LLSLLQS-----PVADPES---EA---------------- ---------------------LARKVSCKLSLP--------------------------- ------------------------------------------------------------ ----RPGEVSEEV----SPQLT----D-------------------------SADLGDYL KRVL-------QLSDTGDPVS--SDEG-----LRIYEN-KVTPLHLLVVQGSVEQVRLLL AHGVHVD---------------CRTACGYTPLLIATLDQQPDLCALLLERG-ADANLADE EGWAPLHFAA----------------------------QNGDDRTARLLLDHGAHVDAQE HEGWTPLHLAAQ---------------------------------NNFENVA--RLLVSR QADPNVREAEGKTPLHVAAYFGHISLVKLLTGQ-GAE----LDAQQR-----NLRTPLHL AVERGKVRAIQHLLKSGAAPDVLDQSGYSPLHLAAARGKYLICKMLLRYGASLELPTQQG WTPLHLAAYKGHLEIIHLLAESHADLGAPGGMKWTPLHLAARHGEEVVVLALLQCGADPS A------AEQSGWTPLHLAVQRGAFLSVINLLEHRADVHARNKVGWTPAHL--------- ----------AALKGDVSILKVLIEAGAQLDIRDGVGCTPLQLALQNQKQNMIAFLEGKG PPLATLGGAEPAAQTEV >P_pygmaeus_ENSPPYP00000012771 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GDGGTPW----------ALGLLRTFDAGEF-TGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VCRARPRA--CSHLIRLMQRC WQGDPRVRPTF------------------------------------------------- -QEITSETED----------LCEKPDD-----EVKETA----HD---------------- -----------------------LDVKSPLEP-RSEVVPVSARLKRA-SAPTFDNDYSLS EL-------------LSQL--DSGVSQAVEGPEELSRSS--------------------- SESKLPSSGSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTSDLGTTDVQ KKKLVDAIVSGDTNKLMKILQ--PQDV-----DLALDS-GASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRRGSTPLHMAVERRVRGVVELLLARK-ISVNAKDE DQWTALHFAA----------------------------QNGDESSTRLLLEKNASVNEVD FEGRTPMHVACQ---------------------------------HGQENIV--RILLRR GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAVTSDG YTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV--SADVI DL-----FDEQGLSALHLAAQGRHAQTVETLLRHGAH----------------------- -----------------INLQSLKFQGGH--------GPAATLLRRSKT----------- ----------------- >M_musculus_ENSMUSP00000034792 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MVPHR--------ARRLLNPM--- ---------------------AVGPLAQ----------QLGSLTVFTRDDFEEEWHLVAS GG-------FSKVFQARHKR-----WRTQYAIKCSPCLQKET--TSSEVTC-LFEEAVKM EKIKFQHIVSIYGVCKQP--------LGIVMEFMASGSLEKTLPT-------HS----LC WPLKLRIIH-ETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQST- --QKQYIERSA------------LRGTLSYIPPEMFLEN--NKA-PGPEYDVYSFAIVIW EIL-T-QKKPYA--G-LNMMTIIIRVAAGM-RPSLQD--VSDEWPEE--VHQMVNLMKRC WDQDPKKRPCF------------------------------------------------- -LNVAVETDM----------LLSLFQS-----PMTDPGC---EA---------------- ---------------------LTQKVSCKPSLS--------------------------- ------------------------------------------------------------ ----QPHKVSKEV----NQEIA----D-------------------------S-VSSDSL KWIL-------QLSDSKSLVA--SD---------VYEN-RVTPLHFLVAGGSLEQVRLLL SHDVDVD---------------CQTASGYTPLLIATQDQQPDLCALLLAHG-ADTNLADE DGWAPLHFAA----------------------------QNGDDHTARLLLDHGALVNARE HEGWTPLHLAAQ---------------------------------NNFENVA--RLLVSR QADLSPHEAEGKTPLHVAAYFGHIGLVKLLSGQ-GAE----LDAQQR-----NLRTPLHL AVERGKVRAIQHLLKCGALPDALDHSGYSPLHIAAARGKDLIFKMLLRYGASLELRTQQG WTPLHLATYKGHLEIIHQLAKSHVDLDALGSMQWTPLHLAAFQGEEGVMLALLQCGANPN A------AEQSGWTPLHLAVHKGTFLGITHLLEYGADIHACNKVGWTPAHL--------- ----------AALKGNTAILKVLVKAAAQVDVKGGVSCTPLQLAIHSPK----------- ----------------- >P_pygmaeus_ENSPPYP00000006485 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CVKLWPS----------GAPA-PLVSIEEL-ENQELVGK GG-------FGTVFRAQHRK-----WGYDVAVKI------------VNSKA-ISREVKAM ASLDNEFVLRLEGVIEKVN-WDQDPKPALVTKFMENGSLSGLLQS-------QCP---RP WPLLCRLLK-EVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ- --SGTGSGE--------------PGGTLGYLAPELFVNI--NRK-ASTASDVYSFGILMW AVL-A-GREVEL---PTEPSLVYGAVCKRQTRPSLAE--LPQAGPETPGLEGLKELMQLC WSSEPEDRPSF------------------------------------------------- -QECLPKTDE----------AFRMVEN------HMNAAVSTVKN---------------- -----------------------FLSELRS------------------------------ ------------------------------------------------------------ -----------------SNRRF----STPESG-----QGGTEMDGFRRTTENQHSRNDVM VSEWLNKLNLEGPPSSV------PKKC-----PSLTKR----------SRAQEEQVPQAR TAGTSSD---------------SMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAE RQGMNWSCRT----------------------------PEPNPVTGRPLVN--------- --------------------------------------------------IY--NCSGVQ VGDNNYLTMQQTT---ALPTWGLAPSGKGRGLQHPPP-----VGSQE-----SPKDPEAW SRPQGWYNHSGK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000027243 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CVKLWPS----------GASA-SLVSIEEL-ENQEFVGR GG-------FGTVFRARYRK-----WGYDVAVKI------------VNSKA-ISREVKAM ASLDNEFVLRLEGVIEKVN-WDHVPKPALVTKFMENGSLYRLLQP-------ECP---RP WPLLCRLLK-EVVLGMFYLHNQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ- --SGTASRE--------------PGGTLGYLAPELFVNV--NRK-ASTASDVYSFGILMW AVL-A-GREAEL---PTEASLVCGAVCRRQTRPSLTE--LPQAGPETPGLEGLKELMQLC WSTEPKDRPSF------------------------------------------------- -QECLPKTDE----------AFQMVEN------NINAAVSTVKN---------------- -----------------------FLSELRS------------------------------ ------------------------------------------------------------ -----------------SNPRF----STPESG-----QGGTEMDGFRRTTGNQHSRNDVM VSELLNKLNLEGSPSSV------PEKY-----PSLTKR----------SRAQEEQVLQAR TAGTSSD---------------SVAQPPQTPETSTFRNQMPSPTSTGTPSPGPQGNQGAE RHGMNWSSRT----------------------------PEPNPVTGRPLIN--------- --------------------------------------------------LH--NCSGVQ VGDNNYLTMQQTT---ALPTGGLAPSGTGRGWQHPPP-----IGSQE-----GPEEPENW SGPHGWYNHSGK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000063433 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MD--- ---------------------VPENSPG----------IMGLLKTFDASEF-GSWEKIGS GG-------FGQVYKVRHMQ-----WKTWLAIKCPPSLHSDD----KERAE-LLEEAKKM EAAKFRYILPVYGICSDP--------QGLVMEYMETGSLETLLAT-------EP----LP WELRFRIIH-ETAVGMNFLHCMNPPLLHLDLKPANILLDAHYHIKISDFGLARWNGFAR- --D-DDISRDG------------FCGTIAYLPPERIIEK--DRI-SDTKHDVYSFSIVIW GIL-T-QKKPYQ--GENNILHIMVKVVKGV-RPDLSL--IPRSRPQA--CSGFLSLMQKC WAQSPQARPSF------------------------------------------------- -EEITSEAEE----------LCTKPHE-----ESRASVS---SE---------------- -----------------------PECSPCPAPASSEQTNDQKPVRPK-SAMLPEKDYSLS EL-------------LTQI--DSGFSRSLSNVQEESLES--------------------- KD------NTSKRLS--GISSV----DSAFSS-----QGSITLSFDKENAVND--SSELQ KKKLCDAIRTEDIAKLMKILQ--PQDV-----DLLLDG-GSNLLHYAVSLANEEAVKFLL LSNCNPN---------------LANAQGATPLHQAAEKRLKGVSEILLSRKTTNVNAKDE DQYTPLHFAA----------------------------QNGDEALTRLLLDRSASINETD AQGRTPTHIACH---------------------------------HGQENVV--RVLLSR GADVHVKGKDDWTALHLAAWKGHLGIVKLLVKQAGAD----VDGQTS-----DGRSPLHL ASQRGQYRVARILVELGANVHLTSDDLYAPLHVAAETGHTSTSRLLVKHDADIKSRTANG CTALHLASQKGHLPTVKMLLAEGADPESVNHDLRTPCHLAAQNGHCEVLKELLRSCSDVA NA-----QDRNGLTALHLAVSGGHKDAICVLLEGGAD---AAPLTPQPVGDRSFDYTSES EP--------ESPNPLTPTRKVVILKLTNRKNSEHTLIPVDARCESAPC----------- ----------------- >E_caballus_ENSECAP00000006458 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------RERME-LLEEAKKM EMAKFRYILPVYGICQEP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIVH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVMW GVL-T-QKKPFA--DEKNILHIMVKVVKGH-RPELPP--VCRPRPRA--CGNLIRLMQRC WHGDPRERPTF------------------------------------------------- -QEITSETED----------LCEKPDE-----EVKEMT----RD---------------- -----------------------LDVKTPPAP-KSEA-PVPAPLKRA-SAPTFDTDCSLS EL-------------LSQL--DSGISQTLEGPEELSRSS--------------------- SESKLPSANSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTGDLGTTDVQ KKKLVDAVVNGDTSRLMKILQ--PQDV-----DLVLDG-GASLLHLAVEAGQEECVKWLL LNNANPN---------------LTNRKGSTPLHLAVERRVRGVVELLLSRK-ISINATDE DQWTALHFAA----------------------------QNGDECSTRLLLEKNASINEVD FEGRTPMHVACQ---------------------------------HGQESIV--RILLRR GVDVGLQGKDAWVPLHYAAWQGHLPIVKLLAKQPGVS----VNAQTL-----DGRTPLHL AAQRGHYRVARILIDLRSDINVRNLLAQTPLHVAAETGHTSTARLLLHRGASREAVTAEG CTALHLASRNGHLATVKLLVEEKADVLARGPRNQTALHLAAASGHSEVVEELV--SADVL NL-----ADEQGLSALHLAAQGRHAKTVETLLKHGAH----------------------- -----------------VNLQSLKFQGSH--------SPSATLLRRSKT----------- ----------------- >G_gorilla_ENSGGOP00000004618 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CVKLWPS----------GAPA-PLVSIEEL-ENQELVGK GG-------FGTVFRAQHRK-----WGYDVAVKI------------VNSKA-ISREVKAM ASLDNEFVLRLEGVIEKVN-WDQDPKPALVTKFMENGSLSGLLQS-------QCP---RP WPLLCRLLK-EVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ- --SGTGSGE--------------PGGTLGYLAPELFVNV--NRK-ASTASDVYSFGILMW AVL-A-GREVEL---PTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLC WSSEPKDRPSF------------------------------------------------- -QECLPKTDE----------AFQMVEN------NMNAAVSMVKN---------------- -----------------------FLSQLRS------------------------------ ------------------------------------------------------------ -----------------SNRRF----SVPESG-----QGGTEMDGFRRTIENQHSRNDIM VSEWLNKLNLEEPPSSV------PKKC-----PSLTKR----------SRAQEEQVPQAW TAGTSSD---------------SMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAE RQGMNWSCRT----------------------------PEPNPVTGRPLVN--------- --------------------------------------------------IY--NCSGVQ VGDNNYLTMQQTT---ALPTWGLAPSGKGRGLQHPPP-----VGSQE-----GPKDPEAW SRPQGWYNHSGK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000037036 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MVPHR--------ARRLPDPM--- ---------------------AVRPLEQ----------QLGSLTVFTRDDFEEEWHLVAS GG-------FSQVFQARHKR-----WRTQYAIKCSPCLQKET--TSSEVSC-LFEEAVKM EKIKFQYIVSIYGVCKQP--------LGIVMEFMANGSLEKILPT-------HS----LC WQLKFRIIH-ETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKWMEQST- --QKQYIERSA------------LRGTLSYIPPEMFLEN--NKA-PGPEYDVYSFGIVVW EIL-T-QKKPYA--G-LNMMTIIIQVAAGM-RPSLHD--VSAEWPEE--AHQMVDLMKLC WDQDPKKRPCF------------------------------------------------- -LNVIIETDM----------LLSLFQT-----PVADPEY---EA---------------- ---------------------LTRKVSYKSSLS--------------------------- ------------------------------------------------------------ ----QPHRVSKEV----SQEIA----D-------------------------S-DSDDSL KWIL-------QLSDSKSLVP--SD---------IYEN-KVTPLHFLVARGSLEQVRLLL SHEVDVD---------------CQTASGYTPLLIATQDQQPDLCALLLAHG-ADTNLADE DGWAPLHFAA----------------------------QSGDDHTARLLLDHGALVNARE HEGWTPLHLAAQ---------------------------------NNFENIA--RLLVSR QADLNPCEAEGKTPLHVAAYFGHIGLVKLLTGQ-GAE----LDAQQR-----NLRTPLHL AVEKGKVRAIQHLLKRGALPDVLDHNGYSPLHIAAAKGKYLIFKMLLRHGASLELCTQQG WAPLHLATYKGHLEIIHLLAKSHADLDALGSMQWTPLHLAAFCGEEGMMLALLQCGANPN A------AEQSGWTPLHLAVHKGTFLGIVHLLEHGADVHACNKVGWTPAHL--------- ----------AALKGNTEILKVLVKACARLDAKDGVGCTPLQLALRSLK----------- ----------------- >H_sapiens_ENSP00000216274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CVKLWPS----------GAPA-PLVSIEEL-ENQELVGK GG-------FGTVFRAQHRK-----WGYDVAVKI------------VNSKA-ISREVKAM ASLDNEFVLRLEGVIEKVN-WDQDPKPALVTKFMENGSLSGLLQS-------QCP---RP WPLLCRLLK-EVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ- --SGTGSGE--------------PGGTLGYLAPELFVNV--NRK-ASTASDVYSFGILMW AVL-A-GREVEL---PTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLC WSSEPKDRPSF------------------------------------------------- -QECLPKTDE----------VFQMVEN------NMNAAVSTVKD---------------- -----------------------FLSQLRS------------------------------ ------------------------------------------------------------ -----------------SNRRF----SIPESG-----QGGTEMDGFRRTIENQHSRNDVM VSEWLNKLNLEEPPSSV------PKKC-----PSLTKR----------SRAQEEQVPQAW TAGTSSD---------------SMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAE RQGMNWSCRT----------------------------PEPNPVTGRPLVN--------- --------------------------------------------------IY--NCSGVQ VGDNNYLTMQQTT---ALPTWGLAPSGKGRGLQHPPP-----VGSQE-----GPKDPEAW SRPQGWYNHSGK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000020312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- A--------------------E-----P----------VCSALPAIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHSPLLDSERND-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KIEYPDVP WPLRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIVYMPPENYEPG--QKARASVKHDIYSYAIIIW EVL-S-RKQPFE--DVTNPLQIMYSVSQGH-RPDTNEESLPFDIPHR---ALMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQNAS---RTVHLSDKKKR--ELSPNIPVNS-GPR EE-S-CGS---SQLHKTSG--SPGTSRSLSAPQDKDFLSAKT------------------ QD-----FSALHQCS--VNHSR----NSDFCV-----DCQVA----------------FC DHR--------TAPCSLAIVN--PLSA-----EGNSGRFQPGIAQQWIQSKREDIVSQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--RVIVQK LKDN-----------------------KQMGLQPYPE----ILVLSQ-------SPSLNF FHNKSHKK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >A_carolinensis_ENSACAP00000005303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------KEAGSPL----------AMGLLKTFDSGEF-VSWEKIGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSPHVDE----KERME-LLEEAKKM EMAKFRYILPVYGICKEP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LCGTIAYLPPERIKEK--NRY-FDTKHDVYSFSIVIW GVL-T-QKKPFS--EENNILHIMVKVVNGL-RPELP---VPKSRPHA--CNNLIKLMQKC WQDDPSKRPTC------------------------------------------------- -QEITSETED----------LCEKPEN-----GNKEVID---QE---------------- ------------------------DAKTTRTY---PKVSRLSQLKQE--GPVSAKDYSLS EL-------------LSQL--DSGISETQQ-PEELSRSA--------------------- SESRL--ASSDKRLS--GVSSV----DSAFSS-----RGSLSLSFERENSGNDMDSTDIQ KRKLAEAITSGDTGKLMKILQ--PQDV-----DLVLDG-NNSLLHLAVESGQEECAKWLL LYNANPN---------------MTNKRGSTPLHIAIEKKNKSIVELLLARK-INVNAKDE DQWTALHFAA----------------------------QNGDELSTRMLLEKNALPNEVD FEGRAPIHIACQ---------------------------------HGQENIV--RIFLRR GVDVDIKGKDDWVPLHYAAWQGHLSIVKLLAKQAGVN----VNSQTV-----DGRTPLHL AAQRGHYRVARILIELQSDVNIRNVFCQTALHVAAETGHTSTSRLLLNRGADIEAVTMEG CTALHLAARNGHLSTTKLLIEEGAGVMARGPLNRTALHFAAENGHDEVAKELV--NLENI ND-----SDEEGLTALHLAARGGHTCTVQILLKHRAL----------------------- -----------------AGMPSLSFQ---------------------------------- ----------------- >M_musculus_ENSMUSP00000038833 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------D-----A----------ICSALPPIPYHKL-ADLHYLSR GA-------SGTVSSARHAD-----WRVRVAVKH---LHIHTPLLDSERND-ILREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDIA WPLRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSYKSAP-----------EGGTIIYMPPENYEPG--QKSRASVKHDIYSYAVIMW EVL-S-RKQPFE--EVTNPLQIMYSVSQGH-RPDTSEENLPFDIPHR---GLMISLIQSG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFED-----ITFLEAVIQLKK---------------- -----------------------AKIQSSS---STIHLCD-KKM--DLSLNIPANH-PPQ EE-S-CGS---SLLSRNTG--SPGPSRSLSAPQDKGFLSGAP------------------ QDCS---SLKAHHCP--GNHSW----DGIVSV-----PPGAA----------------FC DRR--------ASSCSLAVIS--PFLV-----EKGSERPPIGIAQQWIQSKREAIVSQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TSD---------------------------------IQGEEFA--KVVVQK LKDN-----------------------KQLGLQPYPE----VPVLSK-------APPSNF PQNKS--L---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000028318 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------GESRGPW----------ALGLLRTFDAGEF-AGWEKVGS GG-------FGQVYKVRHVH-----WKTWLAIKCSPSLHVDD----RERME-LLEEAKKM EMAKFRYILPVYGICREP--------VGLVMEYMETGSLEKLLAS-------EP----LP WDLRFRIIH-ETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSH- --S-HDLSMDG------------LFGTIAYLPPERIREK--SRL-FDTKHDVYSFAIVIW GVL-T-QKKPFA--DEKNILHIMVRVVKGH-RPELPP--VCKPRPRA--CRSLLRLMQRC WHGDPRERPSF------------------------------------------------- -QEITSETED----------LCEKPDE-----EVKETT----QD---------------- -----------------------PDVRDPPDA-EAEA-PVPTPLKRA-SAPTFDNDYSLS EL-------------LSQL--DSGISQTLEGPEELSRSS--------------------- SESKLPSASSGKRLS--GVSSV----DSAFSS-----RGSLSLSFEREPSTNDLGTTDIQ KKKLVDAIVSGDTSRLMKILQ--PQDV-----DLVLDG-GASLLHLAVEAGQEDCVKWLL LNNANPN---------------LTNRRGSTPLHVAVEKRVRGIVELLLARK-ISVNAADE DQWTALHFAA----------------------------QNGDEGSMRLLLEKNASVHEAD CEGRTPMHVACQ---------------------------------HGQEGVV--RILLRR GVDAGLPGKDAWVPLHYAAWQGHLPIVKLLAKQPGVS----VDAQTL-----DGRTPLHL AAQRGHYRVARVLIDLHSDVNVCNLLAQTPLHVAAETGHTSTARLLLHRGAHREAVTAEG CTALHLAARNGHLATVKLLVEERANMLARGPRSQTALHLAAAGGHSEVVEELV--SADVL DL-----SDEQGLSALHLAAQGRHTKTVETLLRHGAH----------------------- -----------------VNLQSLKFQGGP--------SPAATLLRRSKT----------- ----------------- >P_troglodytes_ENSPTRP00000010556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------CVKLWPS----------GAPA-PLVSIEEL-ENQELVGK GG-------FGTVFRAQHRK-----WGYDVAVKI------------VNSKA-ISREVKAM ASLDNEFVLRLEGVIEKVN-WDQDPKPALVTKFMENGSLSGLLQS-------QCP---RP WPLLCRLLK-EVVLGMFYLHDRNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ- --SGTGSGE--------------PGGTLGYLAPELFVNV--NRK-ASTASDVYSFGILMW AVL-A-GREVEL---PTEPSLVYEAVGNRQNRPSLAE--LPQAGPETPGLEGLKELMQLC WSSKPKDRPSF------------------------------------------------- -QECLPKTDE----------AFQMVEN------NMNAAVSTVKN---------------- -----------------------FLSQLRG------------------------------ ------------------------------------------------------------ -----------------SNRRF----SIPESG-----QGGTEMDGFRRTIENQHSRNDVM VSEWLNKLNLEEPPSSV------PKKC-----PSLTKR----------SRAQEEQVPQAW TAGTSSD---------------SMAQPPQTPETSTFRNQMPSPTSTGKPSPGPRGNQGAE RQGMNWSCRT----------------------------PEPNPVTGRPLVN--------- --------------------------------------------------IY--NCSGVQ VGDNNYLTMQQTT---ALPTWGLAPSGKGRGLQHPPP-----VGSQE-----GPKDPEAW SRPQGWYNHSGK------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000010554 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MAAME GDT------------------GYVNIGS----------LTSTLAVIPYQKL-TDLYYLSK GG-------FGTVFKAQHSD-----WRTTVAIKC---LKLDS-VGERERKC-LLKEAEVL HKARFNYIIQIFGICNEPE-F-----FCIITEFMSNGSLDLLLHE-------KETYPVLG WPLRLRILY-EIALGVNFLHNMTPPLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSV- --SKGSGSKPAE-----------MEGTVIYMPPEEYEPS--KNRRADVKHDMYSYAIIMW EVL-S-RQIPFE--EVTNPMQIMFSVLRGK-RPDISQDSLSADIPSR---ETLINLMTDG WTANPDERPSF------------------------------------------------- -LKCLIELEP----------MVRRFDE-----IELLEAVLEIKK---------------- -----------------------SKMRHQSPCCSAQPVCEKRNQ--DNSLNAQMKRLGPW PECSTSGSGSCCAQETEIS--LPGFLTMSNAPFSTPVQPLPASFIAPSLES--------- PESLKDPCCPSNNLN--GFQVVKAMNDLNIPV-----TPALP--------------TTEF DTR--------TDNTPPSLKS--QMQADCSPPLPHSPPLSQGPISSWIAMRRVQIVSQM- -----------------------------------TEACLNQSLDALLARS----MLMRE DYEL---VVN----------------------------QPTRTAKVRQLLD--------- ---------NCH---------------------------------KHDEDFC--RIVVRK LFDN-----------------------KQMGLNPYPT----DISCPTSAAAVPSAPSLPT SCNIPRNF---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_familiaris_ENSCAFP00000018216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------GGRLWQS----------GPRA-PVVPAEEL-ENPEFVGA GG-------FGAVFRAWHRT-----WRTGVAVKI------------LEGNAGISREVRAM ASLCNQHLLLPLGVTQKLQ-WEYACGPALLTPFMENGSLVGLLQP-------HCP---RP WPLLSRLLQ-EVVLGMCYLHSQNPVLLHRDLKPSNVLLDSDLHAKLADFGLSTFQRGSR- --SGAGSG----------------KSAPAYLAPELLPDV--NRK-ASMASDVYSFGILMW AVL-A-GREAEI---VAQTSPVREAVCERQIRPPLTK--LPLPSPETPGLERLKALMQHC WSHEPKDRPSF------------------------------------------------- -QECQPITEE----------ALNLVNK------EMDAAVSTVKK---------------- -----------------------FLCENRG------------------------------ ------------------------------------------------------------ ------------------SRIL----SAPQPG-----PGGIETEGPRGTTGS----HDIT ASEMLSKLSLKESPSSA------PKKW-----TNLPET----------TRAQGDKVQPAR LAGLPSD---------------STASSPQTPETSHFENQMASPNLAQTPGPGPEGNQGAR RRGTNWPPRA----------------------------PGPNPIPGSPIT---------- --------------------------------------------------IC--DSRAVQ VGDYNYLIIQEGT---ALSTQGQAPWGMGRGWQWASH-----KATQT------CPLPWGW TAPQGQFRPHSSC----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000012668 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------A--- ---------------------MASGTEQ----------QCGSLTVFSKEDFEEDWVKVAS GG-------FGCVYQVKHKK-----WRTVYAVKCSPYLLQDPGTERTSVNC-LMEEATKM EKIKFQHIVTIYGVCNSP--------LGIVMEYMARGSLEKILPT-------HK----MS WQLKFRVIH-EMGLAMNFLHSMTPPLLHLDLKPGNILLDGNMHVKISDFGLSKWMEQSS- --RMQYIESSA------------LRGTLSYIPPEMFLQN--TKP-PGIKYDVYSFGIVIW EVL-M-QKKPYA--G-ANMMAIIVKVAAGK-RPCLEP--ISDDWPGE--CQQMVDLMKRC WDQDPKQRPSF------------------------------------------------- -TDIPVETDM----------LLSLIQS-----LVVDPEN---ER---------------- ---------------------LVRKMSHKPAIA--------------------------- ------------------------------------------------------------ ------GNQQEDP----SFHLY----C----------------------------RGIII SKNK-------EEGNQKRLFPCSPEEI-----WRVHEN-GLTLLHFVVIQGNVGKVKFLL SCKANVN---------------SQAVCGYTPLIVAVQKRSPEICSVLIEHG-ADTNMPDE DGWTPLHFAA----------------------------QNGDDRIVRLLLDHQARVNAQE HDGWTPLHLASQ---------------------------------NNFENVA--RVLLSR QADSNTQEVDGKTALHVAACFGHVGLVKLLASQ-GAD----LEKKQK-----NHRTPLHV AVERGKFRVVHYLLKNGASVNSLDQNHYSALHLAVVRGKYLICEKLIKYGANVELRTDKG WTPLHLASFKGHIEIIHLLKDSCAKLNARGSMGWTPLHLATRYSEEPVVCELLRCGADPN I------TEKSEWAPLHFAVQRGSFLTVINLLECRADVNVKNKVGWTPLHL--------- ----------AVLKGNMAIIKTLIKAGALLNVEDITGCTALQLAIRHQKENIITLLQGKD SLMNALQNRTLVNDVQI >B_taurus_ENSBTAP00000024511 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------GSTLWPS----------GASA-PLVPIEEL-ENPELIGK GG-------FGSVFRAHHRS-----WGVEVAVKI------------VNSRA-ISREVKAM SSLRNTNVLPLLGVTEKLV-WEYVSGPALVTPFMENGSLAVLLQP-------RCP---RP WPLLCQLLQ-ELVLGMCYLHSQNPVLLHRDLKPSNVLLDSELHAKVADFGLSTFQGGSQ- --SGAGSGE--------------SGCTPAYLAPELLANI--NQK-ASRASDVYSFGILTW AVL-A-GREAEM----PQTSLVREAVCERQIRPPLTE--LPPSGPETPGLEELTDLMQKC WSHEPQKRPSF------------------------------------------------- -QECRINTKK----------ALDLVNKGDVSGRKMNAAVFMVKE---------------- -----------------------FLSEHRG------------------------------ ------------------------------------------------------------ ---------------------------SNSPG-----LERTEIDSPRETTGS----HDSL VSEMMN-LNLEGCPSSV------PEKC-----TNLLES----------IGVQREQVPPAW TAETSSD---------------STARPPQTPETLPFRTQNPCPTSAWTPGPGPQGSQGAE RCDTNWPPRG----------------------------PAPNLVPGPWFPT--------- --------------------------------------------------IF--NCQGVQ IGNNNRLIIQGGT---ALSTKGVAPGGVDRGPQCTPQ----GRSSKE-----GPQEPEAW SGP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000012963 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------D-----A----------ICSALPHIPYHKL-ADLHYLSR GA-------SGTVSSARHAD-----WRVRVAVKH---LHIHTPLLDSERND-ILREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPEIA WPLRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSYKSAP-----------EGGTIIYMPPENYEPG--QKSRASVKHDIYSYAVIMW EVL-S-RKQPFE--EVTNPLQIMYSVSQGH-RPNTSEENLPFDIPHR---GLMISLIQSG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFED-----ITFLEAVIQLKK---------------- -----------------------SKIQSAS---STIHLCD-KKM--DLSLNIPASH-PPQ EE-S-CGS---SLLSRNAG--SPGTSRSLSAPQDKGFFHGGP------------------ QDCS---SSKAYHCP--GNHSW----DGIISV-----SQEAA----------------FC DRR--------ASSCSLTVIR--PLLV-----EKSSERPQPGIAQQWIQSKREAIVSQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---IST----------------------------KPTRTAKVRQLLD--------- ---------TSD---------------------------------IQGEEFA--RVIVQK LKDN-----------------------KQMGLQPYPE----VLLVSR-------TPSSNV LQNKT--L---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000020570 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------E-----A----------ICSALPTIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHTPLLDSERND-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIIYMPPENYEPG--QKSRASVKHDIYSYAVITW EVL-S-RKQPFE--EVTNPLQIMYSVSQGH-RPDTNEESLPFDIPHR---ALMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQSAS---STVHLCDKKKM--ELSLNLSVNH-GPQ EE-S-CGS---SQLHKSSS--SLRTSKSLSA-QDNDFLSRKT------------------ ED-----YSVLHHCP--VNHSC----DSNIPA-----AQRAT----------------FC DHK--------TTPCALAIIN--SLSA-----EGNSERLQPGIAQQWIQSKREDIVNQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---VST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--KVIVQK LKDN-----------------------KQMGLQPYPE----IFMASR-------SPSLNL FQNKS--L---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000306678 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------M--- ---------------------AADPTEL----------RLGSLPVFTRDDFEGDWRLVAS GG-------FSQVFQARHRR-----WRTEYAIKCAPCLPPDA--ASSDVNY-LIEEAAKM KKIKFQHIVSIYGVCKQP--------LGIVMEFMANGSLEKVLST-------HS----LC WKLRFRIIH-ETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQST- --RMQYIERSA------------LRGMLSYIPPEMFLES--NKA-PGPKYDVYSFAIVIW ELL-T-QKKPYS--G-FNMMMIIIRVAAGM-RPSLQP--VSDQWPSE--AQQMVDLMKRC WDQDPKKRPCF------------------------------------------------- -LDITIETDI----------LLSLLQS-----RVAVPES---KA---------------- ---------------------LARKVSCKLSLR--------------------------- ------------------------------------------------------------ ----QPGEVNEDI----SQELM----D-------------------------T-DSGNYL KRAL-------QLSDRKNLVP--RDEE-----LCIYEN-KVTPLHFLVAQGSVEQVRLLL AHEVDVD---------------CQTASGYTPLLIAAQDQQPDLCALLLAHG-ADANRVDE DGWAPLHFAA----------------------------QNGDDGTARLLLDHGACVDAQE REGWTPLHLAAQ---------------------------------NNFENVA--RLLVSR QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ-GAE----LDAQQR-----NLRTPLHL AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG WTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN A------AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL--------- ----------AALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKE PSVATLGGSKPGAEMEI >M_domestica_ENSMODP00000017761 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GVEQ----------HLGSLTIFSRDDFEGDWQRVAS GG-------FGQVFRVRHKR-----WRTEYAIKCSPCLLADSSPTSSDMKC-LIEEASKM EKIKFQHIVSIYGVCKQP--------LGIVMEFMAKGSLEKMLPT-------HS----LS WQLKFRIIH-ETALAMNFLHSIKPPLLHLDLKPGNILLDSNMHAKISDFGLSKWMEQST- --RMQYIERSA------------LRGTLSYIPPEMFLES--TKA-PGPKYDVYSFGIVIW EIV-T-QKKPYP--G-FNMMAIIIRVAAGT-RPSLQP--ISDDWPGE--GQQMVDLMKRC WDQDPKKRPCF------------------------------------------------- -TGYHQYYQL----------CIQLIHP-----SICITGS---KTEGKGLKKKKEMTGLKR ECVLGRERDSVTKGADTRKDRISIRVGQQSKLARMLDEEGELRSSLIYSAALPLQNEDNQ IL-------------ISRI--KDCMRKLFSSVLEIMRSS--------------------- AINKQPGIKKRTL----NPKLG----DLGFSL-----NSTTEMALENSHPFLSLDSGESL KQLL-------QLSDSESLIS--SMEE-----LGIFEN-NITLLHFLVTEGNVEKVRLLL SQEVDVD---------------CQTAEGYTPLMLAVQDQLSDLCMLLLSQG-ANPNLVDK DGWAPLHFAA----------------------------QNGDDRTARLLLDHGAQVDAQE HEGWTALHLASQ---------------------------------NNFENVA--RLLVSR YANPNLQEREGKAPLHVAAYFGHINLVKLLIGQ-GAQ----LNAQQR-----NLRTPLHL AVEQGKFRVIQHLLKSGATTDLLDQNGYSPLHTAVAKDKYLICRMLLKYGANTELKTEQG WTPLHLAAFQGHLEVLRLLHESNAHLDARGGKDWTPLHLAVRQGEEAVVSFLLQSGADPN K------PEQSGWTPLHLAVQRGAFLSVINLLEYQADVNASNKVGWSPAHL--------- ----------AALKGNT------------------------------------------- ----------------- >T_guttata_ENSTGUP00000000273 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------WLRVAS GG-------FGHVYQVKYRR-----WRTVYAVKCSPYLLQDSSV--DSMNC-LMEEASKM EKIKFQHIVTIYGVCNNP--------LGIVMEYMARGSLERILPT-------HR----MS WQLKFRVIH-EMGLAMNFLHSMSPPLLHLDLKPGNVLLDGNMHVKISDFGLSKWMEQSS- --RMQYIESSA------------LRGTLSYIPPEMFLQN--SKP-PGIKYDVYSFGIVIW EVL-M-QKKPYA--G-ANMMAILVKVAAGK-RPGLEL--VRDDWPGE--CHQMVDLMKRC WDQDPKQRPSF------------------------------------------------- -AG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000021009 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------E-----A----------ICSALPTIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHTPLLDSERKD-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIIYMPPENYEPG--QKSRASIKHDIYSYAVITW EVL-S-RKQPFE--DVTNPLQIMYSVSQGH-RPVINEESLPYDIPHR---ARMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITLLEAVIQLKK---------------- -----------------------TKLRSVS---SAIHLCDKKKK--ELSLNIPVNH-GPQ EE-S-CGS---SQLHENSG--SPETSRSLPAPQDNEFLSRKA------------------ QDCS---FMKLHHCP--GNHSW----DSTISA-----SQRAA----------------FC DHK--------TTPCSSAIIN--PLST-----AGNSERLQPGIAQQWIQSKREDIVNQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---VST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--KVIVQK LKDN-----------------------KQMGLQPYPE----ILVVSR-------SPSLNL LQNKS--M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000027730 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SQ QR-----WAPG------------------------------------------------- -----------TQCMT------------------------------KCENSR-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGDM VTILEACEDKSWYRAKH---------HSSGQEGLLAAAALRQREALSTDPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAIQQ-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESAR-----------------------------HPGDYVLCVSFG------RDVIHYRVL HRD-GH------------LTIDEAVCFCNLMDM---VEHYT--------RDKGAICTKLV KPKRKQ---------------GAKSAEE------E---LAKAGWLLDLQHL-TLGAQIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKLQHRNLVRLLGVILHH--G-----LYIVMEHVSKGNLVNFLRT--------RGRALVS TSQLLQFAL-HVAEGMEYLESKK--LVHRDLAARNILVSEDLVAKVSDFGLAKA----EL RKGLDSS-----------------RLPVKWTAPEALKNG----R-FSSKSDVWSFGVLLW EVF-SYGRAPYP---KMSLKEVSEAVEKGY-RME-----PPDSCPGP-----VHTLMGSC WEAEPSRRPPF------------------------------------------------- -RKIVEKLGR----------ELRSVGV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------AAPAGGQEAEGSAPTRS-QDP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000027276 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------E-----A----------ICSALPTIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHTPLLDSERKD-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIIYMPPENYEPG--QKSRASIKHDIYSYAVITW EVL-S-RKQPFE--DVTNPLQIMYSVSQGH-RPVINEESLPYDIPHR---AHMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQSVS---STTHLCDKKKM--ELSLNIPVNH-GPQ EE-S-CGS---SQLHENSG--SHETSRSLPVPQDNDFLSRKT------------------ QHCS---FMMLHRCP--GNHSW----DSTISA-----SQRAA----------------FC DHK--------TTPCSSATIN--PLST-----AGNSERLQPGIAQQWIQSKREDIVNQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---IST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--KVIVQK LKDN-----------------------KQMGLQPYPE----ILVVSR-------SPSLNL LQNKS--V---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000034905 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------E-----A----------ICSALPTIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHTPLLDSERKD-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIIYMPPENYEPG--QKSRASIKHDIYSYAVITW EVL-S-RKQPFE--DVTNPLQIMYSVSQGH-RPVINEESLPYDIPHR---ARMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQSVS---SAIHLCDKKKM--ELSLNIPVNH-GPQ EE-S-CGS---SQLHENSG--SPETSRSLPA-QDNDFSSRKA------------------ QDCY---FMKLHHCP--GNHSW----DSTISG-----SQRAA----------------FC DHK--------TTPCSSAIIN--PLST-----AGNSERLQPGIAQQWIQSKREDIVNQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---VST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--KVIVQK LKDN-----------------------KQMGLQPYPE----ILVVSR-------SSSLHL LQNKS--M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000220751 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- G--------------------E-----A----------ICSALPTIPYHKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKH---LHIHTPLLDSERKD-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSL- --SQSRSSKSAP-----------EGGTIIYMPPENYEPG--QKSRASIKHDIYSYAVITW EVL-S-RKQPFE--DVTNPLQIMYSVSQGH-RPVINEESLPYDIPHR---ARMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIELEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQSVS---SAIHLCDKKKM--ELSLNIPVNH-GPQ EE-S-CGS---SQLHENSG--SPETSRSLPAPQDNDFLSRKA------------------ QDCY---FMKLHHCP--GNHSW----DSTISG-----SQRAA----------------FC DHK--------TTPCSSAIIN--PLST-----AGNSERLQPGIAQQWIQSKREDIVNQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---VST----------------------------KPTRTSKVRQLLD--------- ---------TTD---------------------------------IQGEEFA--KVIVQK LKDN-----------------------KQMGLQPYPE----ILVVSR-------SPSLNL LQNKS--M---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000020477 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------DVFVAQHDFKA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TNGSDLSFKKGDK LKILH--ERGEWCLAKS---------ISTGDEGYIPSNYVARADSLEVEK---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDV------- ------------------------------------------------------------ --------------SRRETERL-LLA---------------------------------- -------------------------------------------------PGNKPGTFLIR ESET-----------------------------SKGSYSLSIRDHDQQQG-DVVKHYKIR CLDKGG------------FYISPSTTFSSLSEL---VKYYS--------RTADGLCERLN SPC------------------KPKDPQE------P---WAHDEWEIPRDTL-KMTKKLGA GQ-------FGEVWMGYYKN------TQKVAIKTLK-EGTME----PE--A-FLQEANLM KQLQHDRLVRLHAVVTK-E-P-----ILIVTEYMVNGSLLDFLKS--------DEGGKLK MNKLIDMSAQQIAEGMAYIEKKN--YIHRDLRAANILVSETLHCKIADFGLARIIE-TE- YTAQEGA-----------------KFPIKWTAPEAINFG----T-FTIKSDVWSFGILLT EIV-TYGRIPYP---GMTNPEVVRCLDQSY-RMP-----RPDDCPVE-----LYDIMMMC WRQRPEERPTF------------------------------------------------- -DFLQNTLND----------FFIATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYEMQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000004702 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCMKSTLCESLGSGL-E----------RKNSPQTVGAEQRHY VRDPTFEAKHNFLS--QN----SSLLPGQRFQTMEDKVVG-KIMVGLYPYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LHADDLGFKKGER MKILE--EHGEWWKAKS---------LTTNREGFIPSNYVGQADTMETED---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PANRPGSYLIR ESET-----------------------------SKGSFSLSIRVVDDSGA-DSVKHYKIR LMDNGG------------YYISPKITFNDISSM---IKHYH--------NKADGLCRNLD RPC------------------VKPKAQK------P---WDKDAWEIPKECI-KMVKKLGA GQ-------FGEVWMAYYNN------TTKVAVKTLK-PGTMT----VE--A-FLDEANLM KKLQHDRLVRLYAVVTKTE-P-----IYIITEFMANGSLLDFLKS--------DSGCTLP MPKLIDFSA-QIAEGMAYIEKKN--YIHRDLRAANVLVSESLLCKIADFGLARVIEDDE- YSAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDMWSFGVLLY EIV-TYGKNPYP---GMTKGEVISSIQRGY-RMP-----QTDNCPTE-----LYSMMLNC WKEKPEERPTF------------------------------------------------- -EYMQSVLND----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000004326 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ME--- ---------------------VLDSPHG----------NMGLLRTFDCSEF-GSWEKIGS GG-------FGQVYKVRHVR-----WKTWLAIKCPPCLHMDE----KERLE-LLEEAKKM EAAKFRYILPVYGICGDP--------QGLVMEYMETGSLENLLAS-------EP----LP WELRFRIIH-ETAVGMNFLHCMKPPLLHLDLKPANILLDAHYHVKISDFGLARWNGLSR- --A-DDISRDG------------FCGTIAYLPPESIIEK--DRV-SDPKHDVYSFSIVIW GIL-T-QKKPYQ--GENNILQIMVKVVKGV-RPDPGA--VPRCRPPA--CAGFLSLMQRC WATDPNARPSF------------------------------------------------- -QEITSEAEE----------LCVKPQE-----EQKNTTV---SA---------------- -----------------------PG-PSPPKT-PSEQVKDNKLMRPK-SAMLPEKDCSLS EL-------------LSQV--DSGISRSFDRVKENSCHS--------------------- KE------NTCKRLS--GISSA----DSAFSS-----QDSITLSFEKENAC-D--SAEVQ KRKLCDAIRTKDTAKLMKILQ--PQDV-----DLLLDG-GDSLLHHAVMLANEEAVKFLL LNNANPN---------------LANTRGSTALHVATEQHLKPLVELLLGRRSTNVNAKDE DQYTALHWAA----------------------------QNGDEAITRLLLDRGAAINETD GRGRTPAHIACQ---------------------------------HGQENVI--RVLLSR GADVQVKGKDNWTALHFAAWQGHLGIVKLLVKQAGAD----VDGQTT-----DGRTPLHL ASQRGQYRVARILIELGANVHVTSAGLNTPLHMAADTGHTSTSRLLIKHQADVHAQNTLG LTPLHLAAQRGHLATVKMLIEEGADPFRSNRGLCTPFHLAAENGHGEVLKELLLHCPDGS ALSVQAPSDSGVLSPFHLAVEQGYSNIITMLLQHDPPDSEAAESSEPPAAE--------- QP--------APPEAKQLQRKVVILKLTERNDKNFPQSAG-SQCTSALC----------- ----------------- >C_familiaris_ENSCAFP00000013170 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MN--- R--------------------E-----G----------PRCALPTIPCRKL-ADLRYLSR GA-------SGTVSSARHAD-----WRVQVAVKQ---LHIHSPLRDSERND-VLREAEIL HKARFSYILPILGICNEPE-F-----LGIVTEYMPNGSLNELLHR-------KTEYPDVA WPLRFRILH-EIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRTMSL- --SQSRTSKSSP-----------EGGTIIYMPPENYEPG--QKSRASVKHDIYSYAVITW EVL-S-RKQPFE--EVTNPLQIMYSVSQGH-RPNTNEESLPLDIPHR---ALMISLIESG WAQNPDERPSF------------------------------------------------- -LKCLIQLEP----------VLRTFEE-----ITFLEAVIQLKK---------------- -----------------------TKLQSAL---STLHLCDKKEM--ESSLNIPVTH-GPQ EE-S-CGS---SQPHENSV--STGASESLSAPQDNNFLSRKT------------------ QD-----FSPVCHYP--VNHSC----NSNISA-----AQKWT----------------FC DHK--------TTPCALTVIN--PFSA-----EGNTERLQPGIAQQWIQSKREDIVSQM- -----------------------------------TEACLNQSLDALLSRD----LIMKE DYEL---VST----------------------------KPTRTSKVRQLLD--------- ---------TSD---------------------------------IQGEEFA--RIIVQK LKDN-----------------------KQMGLQPYPE----ILVVSR-------SQPLNS FQNKNLKK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000009404 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MEPSA AM-------------------GCVNICN----------LTSNLPVIPYQKL-TDLYYLSR GG-------FGTVFKAQHSD-----WRTTVAIKC---LKLDSPVGERERNC-LLKEAEVL HKARFNHIIQILGICNEPE-F-----FCIVTEYMSNGSLDLLLHQ-------KDVYPSLG WPLRLRILY-EISLGVNFLHNMNPPLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSV- --SKGSGSKPTE-----------MGGTVIYMPPERYDAS--KNHRADVKHDMYSFSIIMW EVL-S-RQIPFE--EVTNPMQIMFSVLRGM-RPEISLDSLPAEIPSR---STLISLMTTG WTSNPDERPSF------------------------------------------------- -LKCLVELEP----------MVRAYDE-----IGFLEAVLEIKR---------------- -----------------------SQLLRRSGCCAVQSECQQREE--GLGRLKERPSLGPV SE-SSSGSGS------DIS--LPGPLTLTLPSNGNTFYGLPSSLVAPALGI--------- LESEKD-IGAGNNLN--GYSPW----HPNIPM-----KTSPN--------------NCDY ETR--------QDNVPLKPQP--HQQ------GAYSPP-SQGPIAEWIATQREEIVAQM- -----------------------------------TEACLNQSLDALLARS----MLMRE DYEL---VRN----------------------------QQTRTAKVRQLLD--------- ---------HCH---------------------------------RHNEDFC--RIVVRK LHDN-----------------------KQMNLKPYPT----DIASPT--APLAGGPPLSL SCNITRNV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_musculus_ENSMUSP00000100967 ------------------------------------------------------------ ------------------------------------------------------------ ----------MAR-----RSSRVSWLAFEGWESRDLPR--VSPRLFGAWHPAPAAARMPT QR-----WAPG------------------------------------------------- -----------TQCMT------------------------------KCENSR-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGDM VTILEACEDKSWYRAKH---------HGSGQEGLLAAAALRQREALSTDPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAIQQ-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESAR-----------------------------HPGDYVLCVSFG------RDVIHYRVL HRD-GH------------LTIDEAVCFCNLMDM---VEHYT--------KDKGAICTKLV KPRRKQ---------------GAKSAEE------E---LAKAGWLLDLQHL-TLGAQIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKLQHRNLVRLLGVILHH--G-----LYIVMEHVSKGNLVNFLRT--------RGRALVS TSQLLQFAL-HVAEGMEYLESKK--LVHRDLAARNILVSEDLVAKVSDFGLAKA----E- RKGLDSS-----------------RLPVKWTAPEALKNG----R-FSSKSDVWSFGVLLW EVF-SYGRAPYP---KMSLKEVSEAVEKGY-RME-----PPDGCPGS-----VHTLMGSC WEAEPARRPPF------------------------------------------------- -RKIVEKLGR----------ELRSVGV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SAPAGGQEAEGSAPTRS-QDP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_elegans_Y48G1C.2.1 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNT LNANRDLLSPG------------------------------------------------- -----------NDVIVTRTVSP------------------------SFYSHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MPARDNVFRKDDH VRILGNTTDPAWYRAR----------NANQEEGLVHADCVVRINGQAYDNGIVRMRASGC DVAPGAASTTSSTSSHHST----------------------------------------- ---AANHQP-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHSMI------- ------------------------------------------------------------ --------------SRENTEKL-LRG---------------------------------- -------------------------------------------------KPD--GTFLVR ESTN-----------------------------FPGDFTLCMSFH------GKVEHYRIE QTSGGQ------------LTCDKEEYFSNLTQL---VSHYK--------RDADGLCHRLV TPIICETATFSSNGSSSFGSSSTVDLED------RTSVFRHAGLVISSNDI-DVGDTIGH GE-------FGDVRLGTYKN-------RKVALKVSKRHGNGM----LD--S-LLDEAKFM VGLSHPNLVTLVGVVLDDV-N-----VYMITEYMANGNLIDLLRS--------RGRHALE RRQLMMFAM-DICQGMCYLESKQ--IVHRDLAARNVLLDDDLVAKVSDFGLAKK----AN SQSHDSAS---------------GKFPIKWTAPEALRHS----Q-FTTKSDVWSFGILLW EIF-SFGRVPYP---RIPIQDVVRYIEKGY-RME-----APEGCPPE-----IFKVMNET WALSAQDRPSF------------------------------------------------- -GQVLQRLTT----------IRNTV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000000763 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ISVKMPT RR-----WTPG------------------------------------------------- -----------TQCIT------------------------------KCEHMK-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGEV VTILEACESKSWYRAKH---------HESGQEGLLAAGAVREREAIPTDPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAVAL-LQP---------------------------------- -------------------------------------------------AED--GLFLVR ESVR-----------------------------HPGDYVLCVSHG------QEVVHYRVL HHG-GR------------LTIDESVCFYNLIDM---IEHYM--------KDKGAICTKLV KPKRKH---------------GTKSAEE------E---LAKAGWLLNLQQL-TLGSQIGE GEPPPGHGHVPAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKIQHKNLVRLLGVILHQ--G-----LYIVMEYMSKGNLVNFLRT--------RGRALVH KAQLLQFSL-HVAEGMDYLEGKK--LVHRDLAARNILISEDHVAKVSDFGLAKA----E- RRGLDTS-----------------RLPVKWTAPEALKHG----K-FSSKSDVWSFGILLW EVF-SYGRAPYP---KMSLKEVSEAVEQGY-RMQ-----APEGCPAS-----VYALMASC WEVEPTRRPAF------------------------------------------------- -RKLLEKLAK----------ELRSTAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EPGPEG----SSVGPQGLQEP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000022427 MIRGAPMGSPTLFWALTLSAFTICILSACGEICGPVIDIRNDISEFNLLEKCTVVEGVLK IVLMNDKTKNINQELFRSLSFPKLTIITDYLLLFRVSGLESLSTLFPNLAVIRGRNLLFN YALVIYEMPHLKDIGLYNLRNITRGALRIEKNSELCYLNSVDWSLIMNAE-TNVISLNKK PE-ECDNVCPGIMVKDEPLCQRTSFNDNHDARCWT----------SNHCQKVCPERC-K- LACTDQGECCHSQCLGSCTEPNNDMACSACLHYHHEGRCVQDCPPGTYKFEGWRCITMDA CSQV-------HLLGDTQFVIHEGECMLECPSGFKRNETN----QMFCSACNGPCDKSCR ----SSMIDSVDAAQSLKGCTVIDGNLHINIRNGNNITSELESFMGLIQTVKGYVKIRHS HALISLSFLKSLRFINGHEL-DNMYAFSSIDNQNLQNLWDWNHHNLTILRGRLFFRQNPK LCMSEIHKMWEKTGRTEKPEEGDF--SNNGARASCKSHILKFKSNATTSHTIGLTWENYR PPEYEGLISFIVYYKESPFQNITEFDGQDGCGSNSWHMVDVDLSHD----QKID--PEVT ---LLHLKP-WTQYAIFVKVITL-QVGDK-------HIKGAKSAIIYIRTRPSLPSMPKD PRAYANSSTQLIVKWSPPVFPNGNLTYYLVRWQRQPEDRELYQHNYCSKK--LKIPIRIS ATGLMDMEENTKPTKSDLDGAGNIQCCTC---PKTPEMKDREKADRV-FFKRFENFLHNS IFTPRP-----------PDRRRRDV-FGVANN----TLFLEGGSRGNTTFGTGDNATESI PPVKHYPFSEGKS-TVEFLEIHNLQPFTVYRIDLHACNEEVGH----------------- ----CSVGAFVYSRTKPA---VGADDIPGKVTYERSETVGGCVLLHWLEPVMPNGLILMY EVKF-RLGNEPEKHKCVSRQHYLEHRGARLTNLGPGNYSAQVRATSLAGNSSWTESMFFY VPPPKR-DDGVTFYLVIIIPIIATLLIASLITILF-FVNKK--------RKSDRLGNGVL YASVNP---------------EYFSAAE------M---YVPDEWEVAREKI-TMHKELGQ GS-------FGMVYEGIAKGVVKDEPEIRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLR--KENSTSEVLPP LKKMIQMAG-EIADGMSYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTMSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEELDPSFREVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDME-VENMENIPLDP---ASARQG----- -----SPLSGCTGGCT--PPPSAQQLSPIQGPGTPLLGPVSPSSLGLVAPSLASPGQALD KHS-GHVSAN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-VVVLRPNFEEMQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000012933 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MTEV-Q TT-----WPQG------------------------------------------------- -----------TECVA------------------------------RYNFKG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TSEQDLPFNKGDL LTIIIVTKDPNWYKAK----------NSAGREGTIPANYVQKREGVK-GGRLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TRDQAELL-LSP---------------------------------- -------------------------------------------------HET--GLYLVR ESTN-----------------------------FPGDYTLCVSCD------GKVEHYRIV YSN-GK------------LTIDDEGFFENLMQL---VEHYT--------KDSDGLCTKLI KPKLEE---------------GTVAAQD------E---FSRGGWSMSRKDL-TLQQAIGK GE-------FGDVMVGDYRG-------TKVAVKCIK--HDAT----AQ--A-FIAEASVM TQLRHDNLVQLLGVIVEENGS-----LYIVTEYMAKGCLVDYLRS--------RGRTVLG VDALLNFAL-DVCEAMAYLEINN--FVHRDLAARNVLVSDDNMAKVSDFGLTKE----A- SSTQDTA-----------------KLPVKWTSPEALREK----K-FSTKSDVWSYGILLW EIY-SYGRVPYP---RIPLKDVVPRVEKGY-KMD-----CPDGCPEV-----VYNIMKQC WNLDPAARPSF------------------------------------------------- -QMLKEWEQH----------ISQDH----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FYL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000017066 MRSGTARDVWTLFWGPALFLSTICLWCARGEVCGPHIDIRNDITEFKKLENCTVVEGYLQ ILLIGDKNNNLNQEHFRTLSFPKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLFYN YALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLLMDAEFNNYIAGNKQ SK-ECGDVCPGIN-EDRPHCIRTSFNDNYSYRCWT----------SNHCQKVCPKECEK- RACTDAGQCCHPQCLGSCTEADNDKACAACQHYFHEDRCVEACPPDTYKFEGWRCITMEM CARV-------HLPSEVDFVIHNGECMPDCPPGFTRNETQ----SMFCSACDGLCDKVCE ----SKTIDSVDAAQSLQGCTVIKGNLQINIRRGNNIASELESFMGLIQTVTGYVRIKHT HTLGSLSFLKSLRYIVGEELVDNTYAFHAVDNHNLQYLWDWTQHNLTIKTGKLYFRFNPK LCMSEIRKMWEKTSVREKMAEDDV--RSNGERASCESYILKFRSNHTQSTRIKLTWERYR PPDYRDLISFIVYYKEAPFQNITEFDGQDGCGSNSWNMVDVDLPQE----KSID--PGVL ---LSPLKP-WTQYAIFVKAVTL-VVEDK-------HVGGAKSEVVYIRTNASAPSMPLD ARAYANSSSSLMVKWSPPIAPNGNKTFYFLRWQQQAEDGELYQHNYCSKE--LKIPIRIS ATSLSDMEGETKPTKSDVAGGEKG-CCPC---PKTKEDLKAEAEDRS-YRKVFENFLHNS IFTPRP-----------PDRKRRDL-MGVANS----TLV-SGVSRNISVL--ESNITQPE LPEKEYPFSEGKV-HTEFMEIHNLRPFTVYRIDIHACNYEVHR----------------- ----CSAAAFVFSRTKPA---DKADDIPGSVTQERDEKGEGIVLLRWPEPLHPNGLILMY EIKY-RLGTEAEKHECVSRQQYKVLRGAQLSNLASGNYSARVRATSLAGNGSWTEPVSFY VPPPKR-NYDNAFYVAIIIPVIVLLLLLFVIVAVI-IVTKK--------RNSDRIGNGVL YASVNP---------------EYFSPFE------M---YVPDEWEVAREKI-TMCRELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASV----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSHLRSLRSKEQGSSSQSLPP LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTNSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIINSIKEELEPPFREVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDME-VENMENVPLDP---ASTLAP----- --SSQGNT------GI--QSQSPQPLSPAQGPGTPLGSAQTPSTSPPSSS--ASPGLALD KHS-GQVAAN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-VVLLGPAFDETQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000020756 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AGRMGCIKSRLDGGVSKGV-E----------EKSSPQTVRTQLARY VRDPTSDINHNI-----N----NSLLPGQRFQTLEEKGVE-KIVIALYPYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LHPDDLGFKKGER MKILE--ERGEWWRAKS---------LSTNREGFIPSNYVGQADTMETED---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PANRAGSYLIR ESET-----------------------------AKGSFSLSVRDVDDGGT-DLVKHYKIR LLDNGG------------YYISPKISFTDISSM---IKHYH--------SKADGLCRKLD RPC------------------VKPKAEK------P---WDKDAWEISKDSI-RMVKRLGA GQ-------FGEVWMAYYNN------ITRVAVKTLK-PGTMT----VE--A-FMDEANLM KKLQHDRLVRLYAVVTKTE-P-----IYIITEYMANGSLLDFLKS--------DLGCSLQ IPKLIDFSA-QIAEGMAYIERRN--YIHRDLRAANVLVSECLLCKIADFGLARVIEDDE- YSAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDMWSFGVLLY EII-TYGKIPYP---GMTKGEVISSIQRGY-RMP-----QPDSCPSE-----LYHMMLDC WKDKPDARPTF------------------------------------------------- -EYMQSVLND----------FYTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000010716 VVSVTSMGRLTLFWGLMLSVSAVCICSTYGEVC-ESMDIRNDISEFKVLENCTVVEGYLH ILLISKKTTN-NVEALRSLSFPKLTVITDHLLLFRVAGLESLSTLFPNLSVIRGRNLFYN YALVIYEMTSLKDIGLYNLRNITRGAVRVAKNSELCYLDSVDWSLITDVVFNNVFDLNKK LE-ECDNVCPGIM-KNSPLCPRTSYTNKLDYRCWS----------SNHCQKVCPDQC-K- LACTDDGQCCHSQCLGGCSEPNSDRACSVCLHYFHNERCVPDCPPGTYKFEGWRCITFEM CSQA-------HLPSDTHFVIHGGECMPDCPSDFTRNKTN----PMLCTACNGPCDKFCT ----SPVIDSVDAAQTLKGCTVINGHLDINIRRGDNIASELENFMGLIRTVKGYVKIRHS HALGSLSFLRSLRYINGEELIENTYSFFAINNQHLQSLWDWSQHNLTIRAGRLFFRQNPK LCMSEIHKMWEKTGITVKPEGGDF--RNNGEKASCESHILKIKSNVTSSYTIKLTWERYQ VPEYGGLINFIVFYKESPFQNITEFDGQDGCGSNSWHMVDVDLSQD----EKLD--PKVT ---LQHLNP-WTQYAIFVRAITL-QVEDK-------HITGAKSDIIYIRTRPSSPSVPKD AHAYANSSTKLLVKWSRPVFPNGNLTYYLVRWQQQPEDRELYQHNYCSKD--LKIPIRVS AGGFSDVEDGAKPTKSDLSGAKKGPCCTC---QKTAEEKDREKDDRV-FIKMFENYLHNI VFYARP-----------PDRQRRDV-VGVANN----TLFPDG-AQGNASLSPAENGTDGV PPVIEYPFSEEKV-STEYLEIPSLQPFTVYRIDIHACNEEVGL----------------- ----CGAGAFVFARTKPA---SEADDIPGKVVPERSDKVEGCMVLHWPEPVVPNGLVLMY EVKY-RLGTEPEKHGCVSRRQYRQNRGARLTHLSPGNYSARVRAISLAGNGSWTESIYFY VPPPKR-DDDVTFYLSIIIPIIVTLFIASLITILF-FINKK--------RNSNRLGNGVL YASVNP---------------EYISAAE------M---YTPDEWEVAREKI-TMHKELGQ GS-------FGMVYEGLAKGVVKDEPETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSHLRSLR--NENSNSQVLPP LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTMSDVWSFGVVLW EIA-TLSEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPTF------------------------------------------------- -LEIINTIKDDLDPSFREVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDME-VENMENIPLDP---VSTRQP----- --AVIHPS-----GST--LPPSAQHLAPMQGPSTPLLGPVSPSHPGYVATTVGSPG--HD KHS-GHVLVN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-VVVLRPNFEEIQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000008826 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCACSDQNHPKGHEHYN----------STNSKTSHASR---- ------------------------------DHKKQNNNQDEDVVIAQYDFQP-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ASENDLQFKKGDR LRIIK--ENGEWWLAKS---------LVTGYEGFIPSTYVARAQTLQVER---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDM------- ------------------------------------------------------------ --------------NRRDTERL-LLA---------------------------------- -------------------------------------------------PGNKPGSFLVR ESET-----------------------------TKGAFSLSIRDSTPEQG-DVVKHYKIR ALDNGG------------YYISPSTSFSSLQEL---VKYYS--------RTADGLCQRLG NPC------------------KSTAPQR------P---WAQDEWEIPRETL-KLVKKLGA GQ-------FGEVWMGFYKN------NQKVAIKTLK-EGTME----PE--A-FLQEANLM KQLQHERLVKLHAVVTR-E-P-----IYIVTEYMANGSLLDFLKT--------DDGHKLK LSKLIDMTA-QIAEGMAYIERKN--YIHRDLRAANILVSETLHCKIADFGLARIIE-TE- YTAQEGA-----------------KFPIKWTAPEAINYG----T-FTIKSDVWSFGILLT EIV-TYGRVPYP---GMTNPEVIRNLDRNY-RMP-----CPDACPGE-----LYDIMTKC WMEKPEDRPTF------------------------------------------------- -EYLQDTLND----------FFIATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYEMQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_familiaris_ENSCAFP00000028300 ------------------------------------------------------------ ------------------------------------------------------------ ----------VAGLDSAVPSQR-----FHGCDGDKEPLPQVSPHFLRAWHPTRISARMPT RR-----WAPG------------------------------------------------- -----------TQCIT------------------------------KCEHMR-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGDV VTILEACESKSWYRAKH---------HASGQEGLLAAGALREREALSADPKLSLM----- ------------------------------------------------------------ --------PWW------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAVQQ-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESAR-----------------------------HPGDYVLCVSFG------RDVIHYRVL HRD-GH------------LTIDEAVCFCNLMDM---VEHYS--------KDKGAICTKLV KPKRKQ---------------GTRSAEE------E---LAKAGWLLNLQHL-TLGARIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKMQHKNLVRLLGVILHQ--G-----LYIVMEHVSKGNLVNFLRT--------RGRALVS TSQLLQFSL-HVAEGMEYLESKK--LVHRDLAARNILVSEDLVAKVSDFGLAKA----E- RKGLDSS-----------------RLPVKWTAPEALKHG----K-FSSKSDVWSFGVLLW EVF-SYGRAPYP---KMSLKEVSEAVEKGY-RME-----PPEGCPGP-----IHALMGSC WEAEPARRPPF------------------------------------------------- -RRLAEKLAR----------EL-CAGA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PALVGGQDTDSSPSPRG-QEP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000040554 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCKKSKLDGDQNGCVLE----------PVNKEHPVRTDQT-Y VRDPTS-YKPPITS--QN----AGLLPGQVFQKMEEKE---KIVVALYPYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHADDLGFKKGEK LKIIE--EHGEWWKARS---------LTTRKEGFIPSNYVAEADTMETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FYKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PANKPGSYLIR ESET-----------------------------SKGSYSLSIRDVDAQGQ-DVVKHYKIR SLDNGG------------YYISPKITFSDISSM---IKHYH--------KQSDGLCRKLD KAC------------------EKPKAQK------P---WDKDAWEISKDSI-KMVKKLGA GQ-------FGEVWMAFYNN------STKVAVKTLK-PGTMS----VE--A-FLEEANLM KTLQHDRLVRLYAVVTKTE-P-----IYIITEYMANGSLLDFLKS--------QAGSKIQ LPKLIDFSA-QIAEGMAYIEKKN--YIHRDLRAANVLVSEMLLCKIADFGLARVIEDDQ- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDMWSFGVLLY EII-TYGKIPYP---GMSNSEVMSSVQRGY-RMP-----RPENCPVE-----LYEIMTTC WKNKPEDRPTF------------------------------------------------- -DYIQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000015019 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGVVSSKKLAKEKGKNQW----------NFKEPHIVFPKTPPP PLPPLVVFNHL-----------TTPTPVLKPDQEE------HYAVALWDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TNDRDLKVVKGEK LQILM--KTGDWWLARS---------LVTKREGYVPSNFVTQVETLEVEK---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKTI------- ------------------------------------------------------------ --------------SRREAERE-LLA---------------------------------- -------------------------------------------------PVNKTGAFLIR ESET-----------------------------IKGAYSLTVKDTTS-AG-NVIKHYKIR ALDDGG------------YYISPRVTFPSLREL---VQHYS--------KKGDGLCQKLT MPC------------------MILAPQT------Q---WAQDEWEVPRHSL-KLVRKLGA GQ-------FGEVWMGYYKN------NIKVAIKTLK-EGSMS----PE--A-FLAEANLM KTLQHDKLVRLYAVVTQ-E-P-----IYIVTEYMAKGSLLDFLKS--------EEGCKLP FSRLIDIMA-QIAEGMAYIEQRN--SIHRDLRAANVLVSESLGCKIADFGLARIV-DSE- YTAHEGA-----------------KFPIKWTAPEAINFG----V-FSIKSDVWSFGILLM EIV-TYGRIPYP---GMTNPEVIRNLERGY-RMP-----CPEMCPAE-----LYSIISKC WRNRPEERPTF------------------------------------------------- -EYLQSVLED----------FYIATEQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYELQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_guttata_ENSTGUP00000011433 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKENLHGDG-L----------DLKNQPVRKTERTIY VRDPTS-NKQQRPG-NPE----AQLLPGQRFVNQDAEEQG-VIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHEEDLSFKKGEK LKVIE--ESGEWWRAKS---------LTTRKEGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNGPGAFLIR ESET-----------------------------LKGNYSLSIRDYDPEHG-DVIKHYKIR SLDNGG------------FYISPRITFPNINDM---IKHYQ--------KQSDGLCRKLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKKLGA GQ-------FGEVWMGYYHN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEFMAKGSLLDFLKS--------DEGSKLL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSDLLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLY EIV-TYGKIPYP---GMSNSDVMVALQRGY-RMP-----RMETCPAE-----LYDIMKTC WKDKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_musculus_ENSMUSP00000022830 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------SVKLWPT----------GASAVPLVSREEL-KKLEFVGK GG-------FGVVFRAHHRT-----WNHDVAVKI------------VNSKK-ISWEVKAM VNLRNENVLLLLGVTEDLQ-WDFVSGQALVTRFMENGSLAGLLQP-------ECP---RP WPLLCRLLQ-EVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQ- SGSGSGSGSRD------------SGGTLAYLDPELLFDV--NLK-ASKASDVYSFGILVW AVL-A-GREAEL---VDKTSLIRETVCDRQSRPPLTE--LPPGSPETPGLEKLKELMIHC WGSQSENRPSF------------------------------------------------- -QDCEPKTNE----------VYNLVKD------KVDAAVSEVKH---------------- -----------------------YLSQHRS------------------------------ ------------------------------------------------------------ -----------------SGRNL----SAREPS-----QRGTEMDCPRET----------M VSKMLDRLHLEEPSGPV------PGKC--------PER-----------QAQDTSVGPAT PARTSSD---------------PVAGTPQIPHTLPFRGTTPGPVFTETPGPHPQRNQGDG RHGTPWYPWT----------------------------P-PNPMTGPPALV--------- --------------------------------------------------FN--NCSEVQ IGNYNSLVAPPRTTASSSAKYDQAQFGRGRGWQPFHK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_anatinus_ENSOANP00000008740 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDDG-I----------DLKSQPVRNTDRTIY VRDPTS-NKQQRPVLCSD----SHLLPGQRFQSKDPEEQG-VIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHQDDLSFKKGEK LKVLE--EHGEWWKAKS---------LSTKREGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------QKGSFSLSIRDFDPQQG-DVIKHYKIR SLDNGG------------YYISPRITFTCISDM---IKHYQ--------KQSDGLCRRLE KVC------------------ISPKPQK------P---WDKDAWEIARESI-KLVKKLGA GQ-------FGEVWMGYYNN------TTKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSEALKCKIADFGLARIIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----S-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALQQGY-RMP-----RMENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000014158 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------MKYEPRFPKYKHHDLTVTSRSPRQK MN-----WAAG------------------------------------------------- -----------TQCVA------------------------------KGDQKK-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QKPGELAYQKGDI LTIVEASTKKGFYKARL---------NTTGEEGLINSSNMRTREALRVDPSLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGPEAVNK-LQP---------------------------------- -------------------------------------------------AED--GLYLVR ESIR-----------------------------HPGDYVLCVSVS------GDVVHYRVI YQD-KQ------------LTIDNTQYFYNLIDM---IEFYS--------KNKGSIATTLL KPKQKQ---------------GTKSAEL------E---LSKSGWLLDITKL-KLGENIGE GE-------FGAVYEGVYMD-------QRVAVKTIK--CDVT----AQ--A-FLQETTVM TKLQHKNLVRLLGVILHK--G-----LHIVTELMTKGNLVNFLRT--------RGRSVIN SVQLLRFAL-DVCEGMEYLEAKR--LVHRDLAARNVLVSDDSLAKISDFGLTKV----D- PKVSDNA-----------------KLPVKWTAPEALKKE----K-FSTKSDVWSYGVLLW EIF-SYGRQPYP---KMSLKEVKERVEGGY-RME-----APDDCPSV-----VYSLMKMC WEQEPRRRPAF------------------------------------------------- -HKLREKLER----------EI-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000313859 ------------------------------------------------------------ ------------------------------------------------------------ ----------MQG---HFPAERREGRPRRGTRGQQQLL--VSPRFLRAWHPPPVSARMPT RR-----WAPG------------------------------------------------- -----------TQCIT------------------------------KCEHTR-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGDV VTILEACENKSWYRVKH---------HTSGQEGLLAAGALREREALSADPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAVQQ-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESAR-----------------------------HPGDYVLCVSFG------RDVIHYRVL HRD-GH------------LTIDEAVFFCNLMDM---VEHYS--------KDKGAICTKLV RPKRKH---------------GTKSAEE------E---LARAGWLLNLQHL-TLGAQIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKMQHENLVRLLGVILHQ--G-----LYIVMEHVSKGNLVNFLRT--------RGRALVN TAQLLQFSL-HVAEGMEYLESKK--LVHRDLAARNILVSEDLVAKVSDFGLAKA----E- RKGLDSS-----------------RLPVKWTAPEALKHG----K-FTSKSDVWSFGVLLW EVF-SYGRAPYP---KMSLKEVSEAVEKGY-RME-----PPEGCPGP-----VHVLMSSC WEAEPARRPPF------------------------------------------------- -RKLAEKLAR----------ELRSAGA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PASVSGQDADGSTSPRS-QEP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000001050 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MSR KH-----WPAG------------------------------------------------- -----------TQCVT------------------------------KHDHTK-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKAGELAFHKGDV VTVIEAVEGRSWYRARH---------NESGQEGLVATGALRERGAIRADPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGVEAVQE-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESVR-----------------------------HPGDYVLCVSFG------KEVIHYRVL HRE-NT------------LSIDSEQYFCNLIDM---IEHYT--------EQQGALCTKLV KPKAKS---------------GMKSAEK------E---LAKAGWLLNLQQL-TLGERIGQ GE-------FGDVLQGEYMG-------QKVAVKNIK--CDVT----AQ--A-FLAETAAM TKVRHKNLVRLLGVILHN--G-----LYIVMEFMSKGNLVNFLRT--------RGRALVP LPQLLQFSL-DVAQGMDYLESKK--LVHRDLAARNILISEDNVAKVSDFGLASV----N- PRGADTT-----------------LLPVKWTAPEALKHN----K-FSSKSDVWSYGILLW EVF-SFGRAPYP---KLSLKEVTEQLEQGY-RME-----PPEGCPPT-----VYVLMRSC WEMEPGKRPSF------------------------------------------------- -KKLTEKLQK----------ELKHL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------KDV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000029288 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKANLHGDG-L----------DLKNQ---------- ------------PA-NTD----AHLLPGQIFANEETEEHG-VIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LHEDDLSFKKGEK LKVIE--ELGEWWKARS---------LTTKKEGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNGPGAFLIR ESET-----------------------------LKGSYSLSIRDYDPQHG-DVIKHYKIR SLDNGG------------FYISPRITFPSINDM---IKHYQ--------KQSDGLCRKLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKKLGA GQ-------FGEVWMGYYHN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEFMAKGSLLDFLKS--------DEGSRLM LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSDLLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLY EIV-TYGKIPYP---GMSNSDVMVALQRGY-RMP-----RMETCPAE-----LYDIMKTC WKDKAKERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_guttata_ENSTGUP00000006771 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCVRSKQAGVQEKMIKT----------DPDPDPGPTIQQGHY VRDPT---------------------ATNKRGLGD------SVVLALYDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MNAGDLSFQKGER MKVLE--KSGEWWQARS---------LVTGHEGFIPSNYVAQENSLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------SRKDAERQ-LLG---------------------------------- -------------------------------------------------PGNMIGSFMIR DSET-----------------------------TKGSYSLSVRDGDELRG-GAVKHYKIR TLDSGG------------FYISPRNNFNTLQEL---VQHYK--------GQSDGLCQKLT HPC------------------RVPKPEK------P---WEKDAWEIPRESL-SLERKLGA GQ-------FGEVWMATYNK------HTKVAVKTMK-PGSMS----VE--A-FLEEANLM KTLQHDKLVKLHAVVTREE-P-----ILIITEFMEKGSLLDFLKS--------DEGNKLL LPKLIDFSA-QIAEGMAFIEKRN--YIHRDLRAANILVSAALVCKIADFGLARVIEDTE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLT EII-TYGRIPYP---GMSNVEVIRALERGY-RMP-----RTDNCPEE-----LYDIMMRC WKIKPEDRPTF------------------------------------------------- -EYIQSVLED----------FFTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000026358 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AS-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCE------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------TDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYDVMKNC WHLDAATRPTF------------------------------------------------- -LQLREQLEH----------IRTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000018594 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKGKDSLNDDG-V----------DLKTQ---------- ------------PV--PE----SQLLPGQRFQAKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LLTKKEGFIPSNYVAKLNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSFSLSVRDFDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQPDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RVENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_musculus_ENSMUSP00000034863 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCE------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------TDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAATRPTF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000019135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MTNV-Q AP-----WPQG------------------------------------------------- -----------TECVA------------------------------RYNFKG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TSAHDLPFKKGDL LTIIVGTKDPNWYKAK----------NAAGCEGTIPANYVQKREGVRSGGKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TRDQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------FPGDYTLCVSCE------GKVEHYRII YHN-GK------------LTIDEEAFFENLMQL---VEHYT--------KDADGLCTKLI KPKLEE---------------GAVAAQD------E---FSRSGWAMNMEDL-TLQQVIGK GE-------FGDVMVGDYRG-------TKVAVKCIK--NDAT----AQ--A-FIAEASVM TQLRHDNLVQLLGVIVEENGS-----LYIVTEYMAKGCLVDYLRS--------RGRSVLD GDALLHFAL-DVCEAMAYLEANS--FIHRDLAARNVLVSEDNVAKVSDFGLTKE----V- SSTQDTA-----------------KLPVKWTAPEALREK----R-FSTKSDVWSYGILLW EIY-SFGRVPYP---RIPLKEVVPRVEKGY-KMD-----CPDGCPEV-----VYNIMKQC WNLDPTARPSF------------------------------------------------- -EMLKEWLQH----------ISQGR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PRQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000046608 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKGKDSLSDDG-V----------DLKTQPVRNTERTIY VRDPTS-NKQQRPV--PE----SQLLPGQRFQTKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LLTKKEGFIPSNYVAKLNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSFSLSVRDFDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQADGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RVENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000020857 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKGKDSLNDDG-V----------DLKTQPVRNTERTIY VRDPTS-NKQQRPV--PE----SQLLPGQRFQTKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LLTKKEGFIPSNYVAKLNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSFSLSVRDFDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQADGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RVENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000012464 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG ----------DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAAMRPSF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000075977 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LFHWCSASE------NIAIALYDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MHEGDLGFKKGDR LRILQ--ESGEWWKAVI---------ISTGQEGFIPSNYVAK-DTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKGV------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------SGNKTGSFMIR DSET-----------------------------TKGSYSLSVRDSDHQA--DTVKHYKIR TLDNGG------------FYISPRITFNTLQDL---VSHYK--------KQSDGLCQSLT SPC------------------LSPKPQK------P---WEKDAWEIPRESL-KLDKRLGA GQ-------FGEVWMAMYNK------HTKVAVKTMK-PGSMS----VE--A-FLMEANLM KSLQHDKLVRLNAVVTKEE-P-----IYIITEFMEKGSLLDFIKS--------DEGNRVQ LPKLIDFSA-QIAEGMAYIEQRN--YIHRDLRAANILVNKSLVCKIADFGLARIIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLT EII-SYGRTPYP---GMTNPEVIRALERGY-RMQ-----RLDSCPQE-----LYDIMLEC WKNKPEDRPTF------------------------------------------------- -EYLQSVLED----------FYTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000043743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LSVFPK AP-----WPQG------------------------------------------------- -----------TECVA------------------------------RYNFKG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TSEHDLPFKKGDV LTIIVVTKDPNWYKAK----------NAAGCEGTIPVNYVQKREGVRSGGKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TRDRAEHL-LHP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------FPGDYTLCVSCE------GKVEHYRII YHN-GK------------LTIDEEMFFDNLMQL---VEHYT--------KDADGLCTRLI KPKLEE---------------GTVAAQD------E---FSRSGWSMNMKDL-KLQQVIGK GE-------FGDVMAGDYRG-------TKVAVKCIK--NDAT----AQ--A-FIAEASVM TKLRHDNLVQLLGVIVEENSS-----LYIVTEYMAKGCLVDYLRS--------RGRTVLG GDALLHFAL-DVCEAMAYLEANN--FIHRDLAARNVLVSDDNVAKVSDFGLTKE----V- SSSQDTA-----------------KLPVKWTAPEALREK----N-FSTKSDVWSYGILLW EIY-SFGRVPYP---RIPLKEVVPRVEKGY-KMD-----CPDGCPEV-----VYNIMKQC WNLDPAARPSF------------------------------------------------- -QMLKEWIQH----------IIQGR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PRK----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000015969 ----AGRGSPTSLWGLLFLFSTLCLWPTNGEICGPHIDIRNEIQELKRLENCTVIEGYLR ILLIS------KAEDYRNFRFPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGKNLFYN YALVIFEMTNLKEIGLYNLRNITRGAIRIEKNSELCYLSTVDWSLILDAVSNNYIVGNKN PK-ECGDLCPGTM-EEKPLCEKTTINNEYSFRCWT----------TNHCQKMCPSSCGK- RACTDQNECCHPECLGSCSAPDNNTACVACRHYYYAGTCVPTCPPNTYKFEGWRCVDKDF CASV----LSAETSEFEKFVIHNDECMQECPSGFIRNGSQ----SMYCSPCEGPCPKVCE GEKKTKTIDSVTSAQMLQGCTVFKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS HALVSLSFLKNLRYILGEEQLEGNYSFYVLDNQNLQQLWDWNLHNLTIKEGKMYFAFNPK LCVSEIYRMEEVSGTKGRQSKGDINTRNNGERASCESDVLHFISNTTMKNRIKLTWQRYR PPDYRDLISFTVYFKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KDVK--PGIL ---LQGLKP-WTQYAIYVKAVTLTMVEND-------HIRGAKSEIVYIRTKAAVPSIPLD VISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHNYCSKD---KVPIRKY ADGTIDVEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PERRRRDV-FQIANS----TM--PSRNRNTTVADHFTNMSDAE EIETEYPFFESRVDNKERTLISHLRPFTLYRIDIHSCNHEADT----------------- --LGCSASNFVFARTMPA---EGADNIPGPVLWE--ERPDNTVHLKWPEPENPNGLILMY EIKY-GQQVE-DQRECISRQEYRKFGGAKLTRLNPGNYSARVQATSLSGNGSWTDPVFFY VPPKTGQDYENFLHLMIALPIAGLFIVGGLLIMWY-VFNKK--------RNSDRLGNGVL YASVNP---------------EYFSAAD------V---YVPDEWEVPREKI-TMSRELGQ GS-------FGMVYEGTAKGVVKDEPETRVAIKTVN-EAASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPETENNPCQMLPT LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTHSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLE-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIIGSIKDELDPGFKEVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDLE-TENMESIPLDP---SSTLQP----- ----------------------------------------------------------AD KHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GPGVVVLRASFDERQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000027659 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ALSLQ MS-----WSAG------------------------------------------------- -----------TQCVA------------------------------KRHHTK-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKTGELAYSKGEI LTILDESEKKGYYRAKH---------NTTGEEGLINSANVRERHALRVVPSLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGPEAACK-LQP---------------------------------- -------------------------------------------------AED--GLFLVR ESIR-----------------------------HPGDYVLCVSFS------GDVIHYRII YQD-NK------------LTIDNKQHFYNLIDM---VEFYS--------KNKGSIATTLL KPKPKQ---------------GAKSAEL------E---LSKNGWLLDIKKL-QLGEKIGD GE-------FGAVYEGEYIG-------QQVAVKIIK--CDVT----AQ--A-FLLETAVM TKLQHKNLVRLLGVIAHK--G-----LHIITELMKKGNLVNFLRT--------RGRSLVP TLQLLRFAL-DVCEGMEYLESKK--LVHRDLAARNVLVSDDIVAKVSDFGLTKA----D- SKVSDDA-----------------KLPVKWTAPEALKKE----K-LSTKSDVWSYGILLW EIF-SYGRQPYP---KMSLREVKEGVEAGY-RME-----APEDCPPA-----VYTLMRTC WEQDPRRRPTF------------------------------------------------- -HKLREKLEQ----------EMTSD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LYV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000001840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CHYPIVPLDGKGKLPIRNGSE VRDPLVTYE-------------GCNPPASPLQD--------NLVIALHSYEP-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SHDGDLGFEKGEQ LRILE--ESGEWWKAQS---------LTTGQEGFIPFNFVAKANSLEPEP---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKNL------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNTHGSFLIR ESES-----------------------------TAGSFSLSVRDFDQNQG-EVVKHYKIR NLDNGG------------FYISPRITFSGLHEL---VRHYT--------NASDGLCTRLS RPC------------------QTQKPQK------P---WWEDEWEVPRETL-KLVERLGA GQ-------FGEVWMGYYNG------HTKVAVKSLK-QGSMS----PD--A-FLAEANLM KQLQHQRLVRLYAVVTQ-E-P-----IYIITEYMENGSLVDFLKT--------PSGIKLT INKLLDMAA-QIAEGMAFIEERN--YIHRDLRAANILVSDTLSCKIADFGLARLIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----T-FTIKSDVWSFGILLT EIV-THGRIPYP---GMTNPEVIQNLERGY-RMV-----CPDNCPEE-----LYQLMRLC WKERPEDRPTF------------------------------------------------- -DYLRSVLED----------FFTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQPQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000020025 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SGPPQVSPRFLGTQHP-PVSARMPT RR-----WAPG------------------------------------------------- -----------TQCIT------------------------------KCEHTR-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PKPGELAFRKGDV VTILEAGESKSWYRAKH---------HASGQEGLLAAGALREREALSADPKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------SGQEAVQQ-LQP---------------------------------- -------------------------------------------------PED--GLFLVR ESAR-----------------------------HPGDYVLCVSFG------RDVIHYRVL HRD-GH------------LTIDEAVCFCNLMDM---VRHYS--------KDKGAICTKLV KPKRKQ---------------GTKSAEE------E---LAKAGWLLELQHL-TLGAQIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKMQHKNLVRLLGVILHQ--G-----LFIVMEHVSKGNLVNFLRT--------RGRALVN TPQLLQFSL-HVAEGMEYLESKK--LVHRDLAARNILISEDLVAKVSDFGLAKA----E- RKGLDSS-----------------RLPVKWTAPEALKQG----K-FSSKSDVWSFGVLLW EVF-SYGRAPYP---KMSLKEVSEAVEKGY-RME-----PPEGCPGP-----VHALMGSC WEAEPARRPPF------------------------------------------------- -RKLAEKLAR----------ELRTASA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SAPAGAQDADGSTLPRD-QEP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000011609 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PAL-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LCP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FFRSGWALNMKDL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYDVMKNC WHLDAATRPSF------------------------------------------------- -LQLREQLEH----------IKAHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000015921 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSILIGELTNGV-E----------EKGSQQAAQTDQAHY VRDPTS-TSKSTRL--KS----NSLLPGQVFQKLEEENKSYKIVIGLYPYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VHSDDLGFKKGEK MKVLE--ERGEWWKARS---------LTTNKEGFIPCNYVAQANTMETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDL------- ------------------------------------------------------------ --------------TRKDAERQ-LMA---------------------------------- -------------------------------------------------PANKPGSYLIR ESET-----------------------------SKGSYSLSIRDRDNQGM-DLVKHYKIR KLDNGG------------FFISPKISFNDIGSM---VKHYH--------SKADGLCRKLE SPC------------------VKPKAQK------P---WAKDAWEISKDSI-KMVKKLGA GQ-------FGEVWMAYYNN------TTKVAVKTLK-PGTMT----VE--A-FLEEANIM KTLQHERLVRLYAVVTKTE-P-----IYIITEYMANGSLLDFLKS--------EVGGKLQ LPKLIDFSA-QIAEGMSFIEKRN--YIHRDLRAANVLVSESLLCKIADFGLARVIEDDE- YSAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDMWSFGVLLY EII-TFGKIPYP---GMTKGEVVSSIQRGY-RMP-----RPENCPTQ-----LYEIMTSC WKFRPEDRPTF------------------------------------------------- -EYMQSVLDD----------FYTATED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQHQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000012392 MIPGAPIGSPTLFWGLTLSVFTICILSACGEICSPGFDIRNDISELNRLENCTVVEGFLQ ILLMNDKTKNINQELFRSLSFPKLTVITEYLLLFRVSGLDSLSTLFPSLTVIRGRNLFYN YALVIYEMPNLKDIGLYNLRNITRGAMRIEKNSELCYLDSVDWSLIMNAEFNNIINLNKK PK-ECDNVCPGIMVKDKPLCQRTSFNDNHEARCWT----------SNHCQKVCPERC-K- LACTDQGECCHSQCLGSCTEPHNDMACSACLHYHHEGRCVQDCPPGTYKFEGWRCITMDL CSQV-------HLLDDTQFVLHGGECMPECPSGFTRNETN----PMFCNACNGPCDKSCP ----SSMIDSVDAAQSLKGCTVIDGNLDINIRHGNNITSELESFMGLIQRVTGYVKIRHS HALVSLSFLKSLRFINGHKLIDNIYAFSAINNQNLQNLWDWNQHNLAILNGRLFFRLNPK LCISEIHKMWEKTGKTEKPEEGDF--LNNGEQASCKSHILKFKSNVTSSHTIGLTWENYR PPGYKGMISFIVYYKESPFQNITEFDGQDGCGSNSWHMVDVDLPQD----QSID--PKIT ---LLHLKP-WTQYAIFVKVITL-QLGDK-------HITGAKSDIIYIRTRPSLPSMPKD PRAYANSSTQLIVKWSPPAFPNGNLTYYLVRWQRQPEDRELYQHNYCSKKPELKIPLRIS ATGHMDMEESTKPTKSDLAGAGNVQCCNC---PKTSEVKDREKDDRL-FFKMFENFLHNA IFLPRP-----------PDRRRRDV-FGVPNS----TLFLEGGVRGNTTIGTGDNTTDSI PPIKEYPFSEGKS-TVEFLEIPHLQPFTVYRIDLHACNEEVGH----------------- ----CSVGAFVYSRTKPA---VGADDIPGKVIYERSDKVEGCVLLHWSEPITPNGLILMY EVKF-RPGNEPEKHKCVSRQHYLEHKGARLTNLGPGNYSAQVRATSLAGNSSWTESLFFY VPPPKR-DDGVTFYLVIIIPILATLLIAGLTTILF-FVNKK--------RNSDRLGNGVL YASVNP---------------EYFSAAE------M---YVPDEWEVAREKI-TMHKELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLR--KENSTSQVLPP LKKMIQMAG-EIADGMSYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTMSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEELDLSFREVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDME-VENMENIPLDP---ASARQPAAAAA ATAAGSPLSGCTGGCT--PPPSTQKLSPIQGPGTPLLGPVSPSSPGPVAPSLASPGQALD KHS-GHVSAN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-VVVLRPNFEEMQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000018983 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCMKSRLTDGLSGGV-E----------GKTGEQTVHTDRMDF VKDPTS-NRTSNCA--PD----NFLLPGQRFQKREEQSGVGKIVISLYPYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LHDDDLGFKKGEK MKILE--EHGEWSKAKS---------LTTNKEGFIPGNYVAQADSMETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PANKPGSYLIR ESET-----------------------------SKGSYSLSVRDVGAEGT-DSVKHYKIR TMDDGG------------YYISPKISFPSIAAM---IKHYH--------HKADGLCRKLD RAC------------------VKPQAQK------P---WDKDAWEISKNSI-KMVRKLGA GQ-------FGDVWMAYYNN------TTIVAVKTLK-PGTMT----AE--A-FMEEANVM KTLQHDRLVRLYAVVTKTP-P-----IYIITEYMANGSLLDFLKS--------DAGCRLQ LPKLIDFSA-QIAEGMAFIERKN--YIHRDLRAANVLVSESLLCKIADFGLARVIEDDE- YSAREGA-----------------KFPIKWTAPEAINYG----T-FTIKSDMWSFGVLLF EII-TYGKIPYP---GMTKGEVISSVQRGY-RMP-----QPGNCPNE-----LYAIVMLC WKNKPEDRPTF------------------------------------------------- -DYMQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000027759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MS--- ---------------------SVKLWLN----------GASSISLVGSEEL-ENLGFVGK GG-------FGAVFRARHTA-----WNLDVAVKI------------VNSKK-ISREVKAM VNLRHENVLLLLGVTENLE-WDYVYGPALVTGFMENGSLSGLLQP-------SCP---RP WPLLCRLLE-EVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLADFGLSTFQGGSQ- --SGSGSGSRD------------SGGTLAYLAPELL-DN--DGK-ASKASDVYSFGVLVW TVL-A-GREAEV---VDKTSLIRGAVCNRQRRPPLTE--LPPDSPETPGLEGLKELMTHC WSSEPKDRPSF------------------------------------------------- -QDCESKTNN----------VYILVQD------KVDAAVSKVKH---------------- -----------------------YLSQYRS------------------------------ ------------------------------------------------------------ -----------------SDTKL----SARESS-----QKGTEVDCPRET----------I VYEMLDRLHLEEPSGSV------PERL-----TSLTER-----------RGKEASFGHAT PAGTSSD---------------TLAGTPQIPHTLPSRGTTPRPAFTETPGPDPQRNQGDG RNSNPWYTWN----------------------------A-PNPMTGLQSIV--------- --------------------------------------------------LN--NCSEVQ IGQHNCMSVQPRT---AFPKKEPAQFGRGRGW---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000046541 MRSSKQRRYWTLFSGLVLVLSTLC----HGEICGPGIDIGNDIGNFKRLENCTVIEGYLQ ILLIGDKNSN-NQEVFRTLSFPKLTMITDYLLLFRVSGLESLSTLFPNLAVIRGRNLFYN YALVIFELTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLILDAELNNFIDGNKQ SK-ECGNVCPGIM-EDNSQC----------TRCWT----------SNHCQKVC--RCGQ- RACTDSGQCCHPQCLGSCSVPDSDRACAACQNYNHEGRCVEDCPPGTYKFEGWRCITRDF CSKV-------HLPDYDRFVIHAGECMSDCPPGFTRDESHGVSVSMLCTACDGPCDKICD ----EKVIDSVDAAQSLKGCTVIKGNLHINIRRGTNIASELENFLGLIKTVTGYIKIRSS HTLTSLSFLKSLRYIHGEELWDNTYAFAALDNQHLQLLWDWSQHNLTISEGKLYFRLNPK LCMSEIRKMWAKTGIKDNFVERDF--RNNGDRASCGTKILKFTSNNTRSNQIKLMWESYR PSDSRDLVNFIVYYKEAPFQNITEFDGQDSCGSDSWNMVDVDLPDE----KILN--PGVV ---LSALKP-WTQYAIFVKAVTL-IVEDRDRDKDRLHL-GPQSEVVYIRTKPSAPSMPVD IRAYSNSSSKLVVRWAPPLAPNGNNTYYLLRWKQQGEDRELYQHNYCSKE--LKIPVRVS ATGLTDTED-TKPTNHETGGRDKTPCCPC---PKTEEDLKRIEDDIY-YRKAFENFLHNA IFTPRP-----------PDRRRRDL-FGVANV----TSIHTLLA-GHWNL-TEGNFSDDE PPRREFSFLERKV-KERHIEITGLQPFTVYRIDLHACNEEVRH----------------- ----CSAAAFVFSRTKAA---EKADDIPGSVTWEGQ---EDSVFLKWPEPDKPNGLIMLY EIQY-RLGTEPEKHECVSRQHYRKHKGVKLSNLGPGNYSVRVRATSLAGNGSWTEPIAFS VHQLEQ-SSYDPVMFIAILPAL--LLIAGLVVFGYTWMNKN--------RNNDRLGNGVL YASVNP---------------EYFSAAE------M---YVPDEWEVEREKI-TMCRELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASL----HERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRS-VENTSSLPLPP LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFIVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTMSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEDLEAGFKETSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDMENVGTMENVPLEP---SSSLQP----- ------------LAPS--ISPPQQCTAAAQSCSSPSSPPSSPS--------------STD KHPLPTSAAN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-SMVLRGPFEEGQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000017416 MSCDTRMRSATLFWGLMLS-FSICIWSTHGEICGPSIDIRNDIEEFKRLLNCTVVEGYLQ ILLITDKTNNIQQEAFRSLSFPKLTVITDYLLLFRVSGLDSLSMLFPNLSVIGGRNLFYN YALVIYEMTSLKDIGLYNLRNITRGALRIEKNPELCYLDSVDWSLIMDAEFNNVINGNKK AK-ECDNVCPGIM-EDNPLCRRTSFNDNLDYRCWT----------SSQCQKVCPEHC-K- LACTDQGECCHSQCLGSCTEPNNDMACSGCLHYYHEDRCVPDCPPDTYKFEGWRCITMDL CSQV-------HLPGDTPFVIHGGECMLDCPSGFTR-EAN----RMFCTPCNGLCDKVCT ----SPIIDSVNAAQSLKDCTIIEGNLDINIRRGNNIASELESFMGLIQTVTGYVKIRHS HALGSLSFLKSLRYISGQELIDNMYSFSAIDNQHLQYLWDWSQHNLTIENGRLFFRLNPK LCMIEIHNMWENTGIAVKPEKGDF--RNNGERASCESHVLKFKSNITTSHSMRLTWERYA PQGYSDLISFVVYYKESPFQNITEFDGQDGCGSNSWHMVDVDLPQD----KIND--PKVS ---LQQLKP-WTQYAIFVKAITL-QVENK-------HITGAKSDIIYIRTRPSPPSMPKD ARAFANSSTTLMVKWSPPAFPNGNLTYYLVRWQQQPEDRELYQHNYCSKE--LKVPIRLP ATGFTDMEDNTKPTKSDLAGGDKGPCCKC---QKTPEEKDREKDDRV-FLKIFENFLHNA IFLPRP-----------PDRRRRDV-FGSAND----TLLHHGVGRGNSTIGPEDNSTDGI PPIREFPFSEDKS-TAEYLEILNLRPFTVYRIDIHACNEEVGR----------------- ----CSAGAFVFSRTKPA---GKADDIPGKVTNGRSDKVEGCVVLHWPEPFMPNGLILMY EIKF-RLETEPEKHECVSRQQYRLYQGARLTNLGSGNYSARVRATSLAGNGSWTDRVFFY VPPPKR-DDGVAFYLVIIIPIIVTLFIATLTTVVF-FVNKK--------RNSDRLGKGVL YASVNP---------------EYFSAAE------M---YVPDEWEVAREKI-TMHKELGQ GS-------FGMVYEGLAKGVVKDEQETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSHLRSLR--KENATSQVLPP LKKMIQMAG-EIADGMSYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTMSDVWSFGVVLW EIA-TLSEQPYQ---GMSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEDLDPPFREMSFFFSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDME-VENMENIPLDP---APTRQP----P TTAATAPSSGCVVGGT--PPPAAQQLSPMQGPGTPLLGPMSPASPGRVAS--ASPGQASD KPS-GHVSAN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-AVVLRPNFDELQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000011384 MKSGAGGGTLAVFCGLLLAFAALCL-GTNGEICGPNVDIRNDIHELKRLENCTVVEGFLQ ILLIS------KAEDYRNFRFPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGRNLFYN YALVIFEMTNLKEIGLHNLRNITRGAIRIEKNSDLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPLCEKTSINNEYNYRCWT----------TNHCQKMCPSSCGK- RACTDQNECCHPECLGSCTAPDNNTACVACRNYYYEGVCMPTCPPNTYKFEGWRCVTKEF CSKV----PATETSDYERFVIHNDECMAECPSGFIRNGSQ----SMFCSPCEGPCPKICE -DGKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS HALVSLSFLKNLRYILGEEQVDGNYSFYVLDNHNLQQLWDWNHHNLTIKEGKMYFAFNPK LCVSEIYRMEEVSGTKGRQSKGDINPRNNGERASCESHILRFVSNTTLKNRIKLTWERYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KEND--PGIL ---LQGLKP-WTQYAIYVKAVTLTMMENH-------HIHGAKSEIVYIRTNAAVPSIPLD VISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQQQPQDSYLYRHNYCSKD---KVPIRRY ADGTIDTEEATEPTKPEGCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PDRKRRDV-FRIANA----TL--ATRNRNITGADHFTNASDAE ESEVEYPFFETKVDGKERTVISHLQPFTLYRIDIHSCNHEADT----------------- --LGCSASNFVFARTMPS---EGADNIPGTVAWE--AKEENTVYLKWLEPTNPNGLILMY EIKY-GQHGE-EKRECVSRQEYKKLGGAKLTHLNPGNYSARVQATSLAGNGSWTEPVSFY VQPKSA-NYDNFLHLIIVLPIAFLLIIGGLLIMLY-VFNKK--------RNSDRLGNGVL YASVNP---------------EYFSASD------V---YVPDEWEVPREKI-TMCRELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPDTESNPGQAPPT LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTHSDVWSFGVVLW EIA-TLAEQPYQ---GMTNEQVLRFVMEGG-LLE-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKDELDPAFKEVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDLE-TENMESIPLDP---SSTLQP----- ----------------------------------------------------------TD KHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GPGVVVLRASFEERQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >X_tropicalis_ENSXETP00000045692 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSVV-Q AP-----WQAG------------------------------------------------- -----------TECIA------------------------------NYDFQG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------KAEQDLHFSKGEV LTIVAVTKDPNWYKAK----------NKVGRVGFIPANYVQKREGVKSGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCE------GKVEHYRII YSS-GK------------LSIDEEEYFENLMQL---VEHYT--------NDADGLCTNLM KPKLVE---------------GTVAAQD------E---FSRSGWALKMRDL-KLLHTIGK GE-------FGDVMLGEHQG-------VKVAVKCIK--NDAT----AQ--A-FVAEAMVM TQLQHNNLVQLLGVIVEDKSG-----LFIVTEFMAKGSLVDYLRS--------RGRSVLG GECLLKFSL-DVSEGMAYLESNN--FVHRDLAARNVLVSEENIAKVSDFGLTKE----A- SAIQDTS-----------------KLPVKWTAPEALRDK--ASL-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIALKDVVPKVENGY-KMD-----APDGCPPV-----VYDLMKQC WHLDPKQRPTF------------------------------------------------- -RNLREQLEH----------IKAKE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LFH----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_aculeatus_ENSGACP00000004798 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCVGSKKEQEPMGKG------------TDDGDQQSHTLTTHY VKDPTVGIPGSKPVSS------SGSVVLGQGAVGE------SIAMALYDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHEGDLGFKKGDK LRILT--ESGEWWKAKL---------ISSGQEGFIPSNYVAK-DTLEAEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKGV------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNRAGSFMIR DSET-----------------------------TRGSYSLSVRDGDPQSG-DTVKHYKIR TLDNGG------------FYISPRNTFTTLQEL---VTHYK--------KQGDGLCQNLT SPC------------------LSPKPEK------P---WEKDAWEIPRSSL-KMDKKLGA GQ-------FGEVWMATYNK------HTKVAVKTMK-PGTMS----VE--A-FMGEANLM KTLQHDKLVRLNAVVTKEE-P-----IYIITEYMEKGSLLDFLKS--------DEGNRLQ LPKLIDFSA-QTAEGMAYIEQRN--YIHRDLRAANILVNKALVCKIADFGLARIIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGVLLT EII-SYGRTPYP---GMTNPEVIRALEKGY-RMQ-----RQESCPTE-----LYDIMLEC WKNKPEDRPTF------------------------------------------------- -DYLQSVLED----------FYTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000026686 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDDG-V----------DLKTQPVRNTDRTIY VRDPTS-NKHQRPV--AD----SQLLPGQRFQTKDPEEQG-DIVIALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--QHGEWWKAKS---------ISTKKEGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSYSLSVRDYDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQSDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RMENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_guttata_ENSTGUP00000008956 MKSGAGGGSLAVVWGFLLVFAALCLWPTNGEICGPNVDIRNDIHELKRLENCTVIEGFLQ ILLIS------KAEDYRNFRFPKLTVITDYLLLFRVAGLESLSDLFPNLTVIRGRNLFYN YALVIFEMTNLKEIGLHNLRNITRGAIRIEKNSDLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPLCEKTSINNEYNYRCWT----------TNHCQKMCPSSCGK- RACTDQNECCHPECLGSCTAPDNNTACVACRNYYYEGVCLPTCPPNTYKFEGWRCVTREF CSKV----PATDASEYEKFVIHNDECMAECPSGFIRNGSQ----SMFCSPCEGPCPKICE -DGKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS HALVSLSFLKNLRYILGEEQVDGNYSFYVLDNHNLQQLWDWNHHNLTISEGKMYFAFNPK LCVSEIYRMEEVSGTKGRQSKGDINPRNNGERASCESKILHFVSNTTLKNRIKLTWERYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KENN--PGIL ---LQGLKP-WTQYAIYVKAVTLTMMENH-------HIHGAKSEIIYIRTNAAVPSIPLD VISASNSSSQLIVKWNPPSLPNGNLSYYIVRWQQQPQDSYLYRHNYCSKD---KVPIRRY ADGTIDTEEATEPTKPEGCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PDRKRRDV-FRIANA----TL--ATRSRNATGTDHFTNASDTE ESEVEYPFFETKVDGKERTVISHLQPFTLYRIDIHSCNHEADT----------------- --LGCSASNFVFARTMPS---EGADNIPGTVSWE--AKEENTVYLKWLEPANPNGLILMY EIKY-GQHGE-EKRECVSRQEYKKLGGAKLTHLNPGNYSARVQATSLAGNGSWTEPISFY VQPKSA-NYGNFLHLVIVLPIVLLFILGALLVMLY-VVNKK--------RNSDRLGNGVL YASVNP---------------EYFSASD------V---YVPDEWEVPREKI-TMCRELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPDTENNPGQAPPT LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTHSDVWSFGVVLW EIA-TLAEQPYQ---GMTNEQVLRFVMEGG-LLE-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIIGSIKDELDPAFKEVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDLE-TENMESIPLDP---SSTLQP----- ----------------------------------------------------------TD KHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GPGVVVLRASFEERQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000268035 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH ILLIS------KAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPMCEKTTINNEYNYRCWT----------TNRCQKMCPSTCGK- RACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDF CANI----LSAESSDSEGFVIHDGECMQECPSGFIRNGSQ----SMYCIPCEGPCPKVCE EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KDVE--PGIL ---LHGLKP-WTQYAVYVKAVTLTMVEND-------HIRGAKSEILYIRTNASVPSIPLD VLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD---KIPIRKY ADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PERKRRDV-MQVANT----TM--SSRSRNTTAADTY-NITDPE ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEK----------------- --LGCSASNFVFARTMPA---EGADDIPGPVTWE--PRPENSIFLKWPEPENPNGLILMY EIKY-GSQVE-DQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFY VQAKTG--YENFIHLIIALPVAVLLIVGGLVIMLY-VFHRK--------RNNSRLGNGVL YASVNP---------------EYFSAAD------V---YVPDEWEVAREKI-TMSRELGQ GS-------FGMVYEGVAKGVVKDEPETRVAIKTVN-EAASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS LSKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTYSDVWSFGVVLW EIA-TLAEQPYQ---GLSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEEMEPGFREVSFYYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KLPEPEELDLE-PENMESVPLDPSASSSSLPL----- ----------------------------------------------------------PD RHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -----------------------------------------GPGPGVLVLRASFDERQPY AHMNGGRKNERALPLPQSSTC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gorilla_ENSGGOP00000010878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSXDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAAMRPSF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000220003 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAAMRPSF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000007539 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VL-Q AA-----WPSG------------------------------------------------- -----------TDC--------------------------------QYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVDITKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAAMRPSF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >H_sapiens_ENSP00000276497 ------------------------------------------------------------ ----------------------------------------------VPLPPRRAALPLAP RPWRLRARRAAASSPRQAGRPRHPRPRASSPSPRVQRSRPAASPYAGPAGPPRRAPHSEL KSPWSSAAPKLSPRAGNMGCIKSKGKDSLSDDG-V----------DLKTQ---------- ------------PV--PE----SQLLPGQRFQTKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LLTKKEGFIPSNYVAKLNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSFSLSVRDFDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQADGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RVENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000033422 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AS-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FYRSGWALNMKEL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKGG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAAMRPSF------------------------------------------------- -LQLREQLEH----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000016020 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LGGR SSCEDPGCPQEEERAPRMGCVKSRFLRDRGKVS--------------KSEPGANPHNPVY VPDPTSAGKRWPDSS-------NNNPPGHTEGAED------TIVIALYDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHHEDLRFQKGDE MVVLE--ESGEWWRARS---------LATGKEGYIPSNYVARVDSLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKGI------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNVLGSFMIR DSET-----------------------------TKGSYSLSVRDYDPQYR-DTVKHY-IR TLDSGG------------LLHLPAEHFGTLQEL---VAHYK--------KASDGLCQKLT VPC------------------MSSKPQK------P---WEKDAWEIPRESL-KMEKKLGA GQ-------FGEVWMATYNK------HTKVAVKTMK-PGSMS----VE--A-FLAEANLM KTLQHDKLVKLYAVVTK-E-P-----IYIITEFMAKGSLLDFLKS--------EEGSKQP LPKLIDFSA-QIAEGMAFIEQRN--YIHRDLRAANILVSASLVCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----S-FTIKSDVWSFGVLLM EIV-TYGRIPYP---GMSNPEVIRALEHGY-RMP-----RPEHCPEE-----LYNIMTRC WKNSPEERPTF------------------------------------------------- -EYIQSVLED----------FYTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000011523 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDDG-I----------DLKTQPVRNTDRTIY VRDPTS-NKQQRPV--SE----SQLLPGQRFQTKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWRAKS---------LSTKREGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSPGAFLIR ESET-----------------------------LKGSFSLSVRDYDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPSISDM---IKHYQ--------KQSDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RMENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_latipes_ENSORLP00000006130 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MTED-Q NP-----WPQG------------------------------------------------- -----------TECVA------------------------------RYSFKG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TSEQDLPFNKGDI LTIIVVTKDPNWYKAK----------NAAGQEGTIPANYVQKREGVKTDGKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TRDQAERL-LNP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------FPGDYTLCVSCD------GKVEHYRII YHN-GK------------LTIDEEVYFENLMQL---MEHYT--------KDADGLCTKLI KPKLEE---------------GTVAAQD------E---FSRSGWSMNRKDL-KLQQVIGK GE-------FGDVMVGDYRG-------TKVAVKCIK--NDAT----AQ--A-FIAEASVM TQMRHNNLVQLLGVIVEENGS-----LYIVTEYMAKGCLVDYLRS--------RGRTVLG GEALLKFAI-DVCEAMAYLETNN--FVHRDLAARNVLVSDDNIAKVSDFGLTKE----A- SSTQDTA-----------------KLPVKWTAPEALREK----N-FSTKSDVWSYGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----CPDGCPEV-----VYNIMKQC WNLDPGARPSF------------------------------------------------- -QMLKEWLHH----------ISHKN----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------HV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000012792 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH ILLIS------KAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPMCEKTTINNEYNYRCWT----------TNRCQKMCPSTCGK- RACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDF CANI----LSAESSDSEGFVIHDGECMQECPSGFIRNGSQ----SMYCIPCEGPCPKVCE EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KDVE--PGIL ---LHGLKP-WTQYAVYVKAVTLTMVEND-------HIRGAKSEILYIRTNASVPSIPLD VLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD---KIPIRKY ADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PERKRRDV-MQVANT----TM--SSRSRNTTAADTY-NITDPE ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEK----------------- --LGCSASNFVFARTMPA---EGADDIPGPVTWE--PRPENSIFLKWPEPENPNGLILMY EIKY-GSQVE-DQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFY VQAKTG--YENFIHLIIALPVAVLLIVGGLVIMLY-VFHRK--------RNNSRLGNGVL YASVNP---------------EYFSAAD------V---YVPDEWEVAREKI-TMSRELGQ GS-------FGMVYEGVAKGVVKDEPETRVAIKTVN-EAASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS LSKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTYSDVWSFGVVLW EIA-TLAEQPYQ---GLSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKEEMEPGFREVSFYYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KLPEPEELDLE-PENMESVPLDPSA---SLPL----- ----------------------------------------------------------PD RHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -----------------------------------------GPGPGVLVLRASFDERQPY AHMNGGRKNERALPLPQSSTC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >G_gallus_ENSGALP00000010524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCVKSKEDSIQEKMQLG----------RGKKDPTSGSKQHDE HRVPV---------------------PPPVDGSGD------SVVLALYDYEA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MHSGDLSFKKGER LQVLE--QLGEWWQARS---------LLTGRKGFIPSNFVARANSLEAEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKSI------- ------------------------------------------------------------ --------------SRKDAERQ-LLG---------------------------------- -------------------------------------------------PGNTLGSFMIR DSET-----------------------------TKGCYSLSVRDGDSLQG-GSVKHYRIR TLDSGG------------FYISSRSSFDTLQEL---VKHYK--------GQSDGLCRRLT YPC------------------SVPRPQK------P---WEKDAWEIPRASL-KLEKKLGA GQ-------FGEVWMATYNK------HTKVAVKTMK-PGSMS----VS--A-FLEEANLM KSLQHDKLVRLHAVVTREE-P-----IYIITEFMEKGSLLDFLKS--------EEGNKQP LPKLIDFSA-QIAEGMAYIEKRN--YIHRDLRAANILVSAMLVCKIADFGLARIIEDNE- YVAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLT EIV-TYGRIPYP---GMSSAEVIRALEHGY-RMP-----RTESCPEE-----LYDVMIRC WKTKPEDRPTF------------------------------------------------- -EYMQSILED----------FFTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQKQA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >E_caballus_ENSECAP00000020913 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSE VRDPLVTYE-------------GSNPPASPLQD--------NLVIALHRYEP-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SHDGDLGFEKGEQ LRILE--QSGEWWKAQS---------LTTGQEGFIPFNFVAKANSLEPEP---------- ------------------------------------------------------------ ----------G------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------PRDDG------- ------------------------------------------------------------ --------------PSLSALRSWLLA---------------------------------- -------------------------------------------------PGNTHGSFLIR ESES-----------------------------TAGSFSLSVRDFDQNQG-EVVKHYKIR NLDKGG------------FYISPRITFPGLHEL---VRHYT--------NASDGLCTRLS RPC------------------QTQKPQK------P---WWEDEWEVPRETL-KLVERLGA GQ-------FGEVWMGYYNG------HTKVAVKSLK-QGSMS----PD--A-FLAEANLM KQLQHQRLVRLYAVVTQ-E-P-----IYIITEYMENGSLVDFLKT--------STGIKLT INKLLDMAA-QIAEGMAFIEERN--YIHRDLRAANILVSDTLSCKIADFGLARLIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----T-FTIKSDVWSFGILLT EIV-THGRIPYP---GMTNPEVIQNLERGY-RMV-----RPDNCPEE-----LYQLMMLC WKERPEDRPTF------------------------------------------------- -DYLRSVLED----------FFTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQPQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_familiaris_ENSCAFP00000010452 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDEG-I----------DLKTQPVRNTDRTIY VRDPTS-NKQQRPT-----------LPANSPPSQNPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--ELGEWWKAKS---------LSTKREGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSYSLSVRDYDPVHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQSDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKRLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTREE-P-----IYIITEYMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RMENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >X_tropicalis_ENSXETP00000003560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MIKCWSG----------NADARPCF-LGDL-EGLQQVGR GG-------FGTVYRGWSRS-----LNMEVALKT------------FQRAQ-SQNEREVM EKASNPFVILLLGMYERQEGE--VSEHGLVMEYVPNGSLRSLFDT-------MD----VP WALRFQMLH-QVALGMNYLHTLDPPIIHRDLKPSNVLLNKHFDVKITDFGLSKIAGATT- --SATPY----------------FAGTPSYMAPEALTDL--NYK-PTMAFDVYSFGIMIW AVL-S-GEEPFP---NAHPALIQLHIPNGQ-RPSLE---VLDHLSHIKMVPEAKELMIKC WSGNADARPSF------------------------------------------------- -LECSHATKL----------MFELYSS------EIKGAIRTMED---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HTHQLQN----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000028559 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSAI-Q AA-----WPSG------------------------------------------------- -----------TECIA------------------------------KYNFHG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TAEQDLPFCKGDV LTIVAVTKDPNWYKAK----------NKVGREGIIPANYVQKREGVKAGTKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LCP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRIM YHA-SK------------LSIDEEVYFENLMQL---VEHYT--------SDADGLCTRLI KPKVME---------------GTVAAQD------E---FFRSGWALNMKDL-KLLQTIGK GE-------FGDVMLGDYRG-------NKVAVKCIK--NDAT----AQ--A-FLAEASVM TQLRHSNLVQLLGVIVEEKSG-----LYIVTEYMAKGSLVDYLRS--------RGRSVLG GDCLLKFSL-DVCEAMEYLEGNN--FVHRDLAARNVLVSEDNVAKVSDFGLTKE----A- SSTQDTG-----------------KLPVKWTAPEALREK----K-FSTKSDVWSFGILLW EIY-SFGRVPYP---RIPLKDVVPRVEKGY-KMD-----APDGCPPA-----VYEVMKNC WHLDAATRPSF------------------------------------------------- -LQLREQLER----------IKTHE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LHL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_rubripes_ENSTRUP00000020710 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KLMIGFQAPWNMSLPFSALRMGSALQLAMEKVNNNP SLLGNYSLDFVFTDTECDPKISLGGFIHQVWKENV----------SALFGPACPEEAEVT GLIASTWNIPMFGFVGQSSKMDSRDTYDSYIKIVPPLKRSAEVLVKTLQFFGWTHVAMIG GGLETNTWDKVDDLWKTV------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ENHLKTHFNVVAT VKFDTSNPQLIYQKIKYIAKVTRVIVILTNKEDCMALLLEAEKQGLMNGDYIFFLVQHFE DNIWKT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GMSSRVNRDAITAFDMAFIIGQKSYEGYEYYDFFERVFERLKGPPF WSNLTSEEEVSPYSAYLHDAVLLYTMGLKEVIKDGMDPHNGQMLLQKLKYKNDIRFYGAS GLVHFDEDGERNLDYSIYDLQHVEGTMKFVPVLHFDSHTKSVRPTSMFKSVVWPKGRPPS DKPRCGFNNELCEWMTNDIALLALLVAFPLMGMLAVSCIGLLVLQKLRLQTRLDDSSWWL INYSDITIIRESQGLRGLSLSNTASHNG----------SSSSQSNFSSNSY-GLKDKTGK EN----------IYTTIGLY-----QGNQVAIKYIKNPYTRN----FQKPS-IIQEFTEM KEMKHENLVQFFGVCIEPP-N-----VCLVMQYCRKGSLKDVLSD---------SDVEMD RIFKLSFAY-DIVNGMDFIHKSNL-KFHGNLKPSTCLVDSRLQIKLSGFGLNEFKYGTR- --NQINLAENS------------NYGDMYWMAPELLRKVGGQVT-GTPKGDVYSFAIILW EIMYNFKSGPYQ-DINLEPKEIIMHLRTPFQGEPLRPLLNDQLCEEN-----INFLLRAC WNENPDHRPPF------------------------------------------------- -GSIRRQLKD----------TCPDSHA-----NILDNMVEKLEK---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------YANHLEEVVEDRTNQLIVEKTRT EKLLSSMLPKYIADQLMAGKS--VEPQSYSVVTIFFSDIVGFTSMCAVSSALEVVSFLND LYSLFDDIIRMYDVYK--VETIGDAYMVASGVPIANGNKHAIEISTMALHFLHSIKVFKI RHMPA------------------------------------------------------- ------------------------------------------------------ESLAIR IGIHSGPVVAGVVGTSMPRYCLFGDTVNMASRMESNS------------------SPLKI HISQCTAEILLQAGSFELEERGEIEIKGKGSHKTYWLLNKRGFNPPVGAHGAPQTDGQKL PPEVH------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >D_rerio_ENSDARP00000095046 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MSTF-E AT-----WPAG------------------------------------------------- -----------TECVA------------------------------RYNFPG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TADQDLPMCKGDV LTIVGVTKDPNWYRAK----------NSAGREGTIPANYVQKREGVKSASKLSLM----- ------------------------------------------------------------ --------P-W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FHGKI------- ------------------------------------------------------------ --------------TREQAERL-LYP---------------------------------- -------------------------------------------------PET--GLFLVR ESTN-----------------------------YPGDYTLCVSCD------GKVEHYRII YHN-GK------------LSIDEEEYFENLMQL---MEHYT--------KDADGLCTRLI KPKIME---------------GTVAAQD------E---FSRSGWALNRKEL-KLIQTIGK GE-------FGDVMVGDYRG-------KKVAVKCIK--HDAT----AQ--A-FVAEASVM TQLRHNNLVQLLGVIVEEKGS-----LYIVTEYMAKGSLVDYLRS--------RGRTVIG GDRLINFSI-IIKKAMEYLEANN--FVHRDLAARNVLVSEDNIAKVSDFGLTKE----A- SSTQDTA-----------------KLPVKWTSPEALREK--KQK-FSTKSDVWSYGILLW EIY-SFGRVPYP---RIPLKEVVPRVEKGY-KMD-----SPDGCPPV-----VYDIMKQC WTLDAVVRPSF------------------------------------------------- -RDLREKLQD----------IITNE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LYR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >R_norvegicus_ENSRNOP00000011130 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDDG-V----------DMKTQPVRNTDRTIY VRDPTS-NKQQRPV--PE----SQLLPGQRFQAKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LSSKREGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGDFSLSVRDYDPMHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQSDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKKLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----AQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEFMAKGDLLDFLKS--------DEGSKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMTALSQGY-RMP-----RMENCPDE-----LYDIMKMC WKESAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >A_carolinensis_ENSACAP00000008770 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VVLALYDYDA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHTEDLSFRKGDH LKVLE--ESGEWWKAKS---------LSNGKVGFIPSNYVARVDSLETED---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------MEAVE------- ------------------------------------------------------------ --------------CRTKRHSE-MLA---------------------------------- -------------------------------------------------SSRSCSLPLLW FTLP-----------------------------GRWSYSLSVRDFDNISKVDIVKHYKIR TLDSGG------------FYISPRNTFNSLQEL---VAHYK--------GQSDGLCQVLT IPC------------------VVPKPEK------P---WEKDAWEIPRESL-KLEKKLGA GQ-------FGEVWIATYNK------HTKVAVKTMK-PGSMS----VE--A-FLEEANIM KTLQHDKLVKLNAVVTKEE-P-----IYIITEFMEKGSLLDFLKS--------DEGRGVQ LPKLIDFSA-QIAEGMAFIEQRN--YIHRDLRAANILVSGILVCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----S-FTIKSDVWSFGILLM EII-TYGRTPYP---GMSNQEVMRALERGY-HMP-----RPESCPVE-----LYDIMLRC WKKKPEDRPTF------------------------------------------------- -ESNQSILED----------FFTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_mulatta_ENSMMUP00000016141 MKSGSGEGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH ILLIS------KAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPMCEKTTINNEYNYRCWT----------TNRCQKMCPSACGK- RACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDF CANI----LSAESSDSEGFVIHDGECMQECPSGFIRNGSQ----SMYCIPCEGPCPKVCE EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTWKNRIIITWHRYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KDVE--PGIL ---LHGLKP-WTQYAVYVKAVTLTMVEND-------HIRGAKSEILYIRTNASVPSIPLD VLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD---KIPIRKY ADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PERKRRDV-MQVANT----TM--SSRSRNTTVADTY-NITDLE ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEK----------------- --LGCSASNFVFARTMPA---EGADDIPGPVTWE--PRPENSIFLKWPEPENPNGLILMY EIKY-GSQVE-DQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFY VQAKTG--YENFIHLIIALPVAVLLIVGGLVIMLY-VFHRK--------RNNSRLGNGVL YASVNP---------------EYFSAAD------V---YVPDEWEVAREKI-TMSRELGQ GS-------FGMVYEGVAKGVVKDEPETRVAIKTVN-EAASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS LSKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTYSDVWSFGVVLW EIA-TLAEQPYQ---GLSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIISSIKDEMEPGFREVSFYYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KLPEPEELDLE-PENMESVPLDPSASSSSLPL----- ----------------------------------------------------------PD RHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -----------------------------------------GPGPGVLVLRASFDERQPY AHMNGGRKNERALPLPQSSTC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000037887 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKTTLPMRNGSE VRDPLVTYE-------------GSNPPASPLQD--------NLVIALHSYEP-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SHDGDLGFEKGEQ LRILE--QNGEWWKAQS---------LTTGQEGFIPFNFVAKANSLEPEP---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKTL------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNTHGSFLIR ESES-----------------------------TAGSFSLSVRDFDQTQG-EVVKHYKIR NLDKGG------------FYISPRVTFPGLHEL---VRHYM--------NTSDGLCTRLS RPC------------------QTQKPQK------P---WWEDEWEVPRETL-KLVERLGA GQ-------FGEVWMGYYNG------HTKVAVKSLK-QGSMS----PD--A-FLAEANLM KQLQHQRLVRLYAVVTQ-E-P-----IYIITEYMENGSLVDFLKT--------SEGIKLT INKLLDMAA-QIAEGMAFIEEQN--YIHRDLRAANILVSHSLSCKIADFGLARLIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----T-FTIKSDVWSFGILLT EIV-THGRIPYP---GMTNPEVIQNLERGY-RMV-----RPDNCPEE-----LYQLMMLC WKERPEERPTF------------------------------------------------- -DYLRSVLED----------FFTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQPQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000011408 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKHSSTHDG-I----------DLKTQPVRNTDRTIY VRDPT--NKQQRPL--PEYHLYSDLLPGQRFQSNDSEE---EMVIAIYPYEG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LHPDDLSFKKGEK MKVLE--EYGEWWKAKS---------LSTKKEGYIPSNYVAKLNSLETED---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLL---------------------------------- -------------------------------------------------PGNRVGAYLIR ESET-----------------------------LKGGFSLSVRDYDPLHG-DVIKHYKIR SLDNGG------------YYISPRITFPTITDL---IKHYQ--------RQPDGLCRRLD KAC------------------ISTQPQK------P---WDKDAWEIPRESI-KLVKKLGA GQ-------FGEVWMGYYNG------STKVAVKTLK-PGTMS----VQ--S-FIEEANLM KTLQHEKLVRLYAVVTKEE-P-----IYIVTEFMAKGSLLDFLKS--------GEGTKLL LPKLIDFSA-QIAEGMAFLERKN--YIHRDLRAANVLVSESLICKIADFGLARIIRDDE- YKAREGA-----------------KFPIKWTAPEAINFG----S-FSIKSDVWSFGILIY EII-TYGKVPYP---GRTNAEVIMALGKGY-RMP-----RMDSCPNE-----LYDIMSMC WKERAEERPTF------------------------------------------------- -DYLQSVLED----------YYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >O_anatinus_ENSOANP00000000255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VCPSVCGK- RACTDQNECCHPECLGSCSAPDNSTACVACRHYYYEGTCVPTCPPNTYKFEGWRCVNRDF CSKV----PGPDINEFEKFVIHNDECMQECPSGFIRNGSQ----SMFCSPCEGPCPKICE EEKKTKTIDSVTSAQMLQGCTVFKGNLLINIRRGNNIASELENFMGLIETVTGYVKIRHS HALVSLSFLKSLRYILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTIKEGKMYFAFNPK LCVSEIYRMEEVSGTKGRQTKGDINTRNNGERASCESDILHFISNTTMKNRIKLTWQRYR PPDYRDLISFTVYYKEAQMKNKHEVR-KGKCMKHGWEKVAQDKPIDARTVKSEK--PNNL ARYMMSLKQ-WAVFPMLSSYVVKHLMFSG-----LGHTYLTSSSLVIVQS----PLSPSN SFSISFTGSSSVPDAFPFSHPNANFFLFAI----------YFVLVYFNAL--TLLPIVLW QSMFPHSSRTSSIARREEIYPGAIILCFC---PVTPTAYIKQMNSRSCLFKQTKQYNQSL IRLFR----------------------GTASG----SSILQPSLPKLSLTEKGSKTPKNN TTPDSWNLSLGVR-TGKSQEHQSARPSRLLRVTLQSLGYSQQESEGTRIVALLNKTIRDS PLFHLPTLAYCLPQFRLAG--KGADNIPGPVTWEG-RKEDNTIYLKWMEPENPNGLILMY EIKY-GQHME-DQRECISRQEYRKYGGARLTRLAPGNYSARVQATSLSGNGSWTEPVSFY VQAKGD------------VRMNVLLIVGGLLIMLY-VFNKKRNAFFPFYRNSDRLGNGVL YASVNP---------------EYFSAADDF-PSSL---YVPDEWEVPREKI-TMCRELGQ GS-------FGMVYEGIAKGVVKDEPETRVAIKTVN-ESASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPDTENNPGQAPPT LKKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTHSDVWSFGVVLW EIA-TLAEQPYQ---GMSNEQVLRFVMEGG-LLE-----KPDNCPDM-----LFELMRMC WQYNPKMRPSF------------------------------------------------- -LEIIGSIKDELDPAFKEVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPDTEELDLE-TENMESIPLDP---SSTLQP----- ----------------------------------------------------------SE KHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GPGVVVLRASFDERQPY AHMNGGRKNERALPLPQSSAC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000010429 ------------------------------------------------------------ ------------------------------------------------------------ ----THRRGLGASGRGRGQSSARGLPPLKTHGTEAPRSASPASSSLERPGTPGAAELGGR SSCEDPGCPPEEERAPRMGCVKSKFLRNGGKVS--------------KTEPNTNPHSPLY VPDPTSSGKRWPDSS-------NGNPPGSTEGSED------IIVVALYDYDA-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHHEDLSFQKGDQ MVVLE--ESGEWWRARS---------LATRKEGYIPSNYVARVNSLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKGI------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNVLGSFMIR DSET-----------------------------TKGSYSLSVRDYDPQHR-DTVKHYKIR TLDNGG------------FYISPRSTFGSLQEL---VAHYK--------KASDGLCQKLT VPC------------------MSSKPQK------P---WEKDAWEIPRESL-KMEKKLGA GQ-------FGEVWMATYNK------HTKVAVKTMK-PGSMS----VE--A-FLAEANLM KTLQHDKLVKLHAVVTE-E-P-----IYIITEFMAKGSLLDFLKS--------EEGSRQP LPKLIDFSA-QIAEGMAFIERRN--YIHRDLRAANILVSASLVCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----S-FTIKSDVWSFGILLM EIV-TYGRIPYP---GMSNPEVIRALERGY-RMP-----RPDNCPEE-----LYNIMTRC WKNRPEERPTF------------------------------------------------- -EYIQSVLDD----------FYTATES--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >C_familiaris_ENSCAFP00000015667 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSD VRDPLVIYE-------------GSNPPASPLQD--------NLVIALHSYEP-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SHDGDLGFEKGEQ LRILE--RNGEWWKAQS---------LTTGQEGFIPFNFVAKANSLEPEP---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKNL------- ------------------------------------------------------------ --------------SRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNTHGSFLIR ESES-----------------------------TAGSFSLSVRDFDQNQG-EVVKHYKIR NLDKGG------------FYISPRITFPGLHEL---VRHYT--------NSSDGLCTRLS RPC------------------QTQKPQK------P---WWEDEWEVPRETL-KLVERLGA GQ-------FGEVWMGYYNG------HTKVAVKSLK-QGSMS----PD--A-FLAEANLM KQLQHQRLVRLYAVVTQ-E-P-----IYIITEYMENGSLVDFLKT--------PPGIKLT INKLLDMAA-QIAEGMAFIEERN--YIHRDLRAANILVSDTLSCKIADFGLARLIEDNE- YTAREGA-----------------KFPIKWTAPEAINYG----T-FTIKSDVWSFGILLT EIV-THGRIPYP---GMTNPEVIQNLERGY-RMV-----RPDNCPEE-----LYQLMMLC WKERPEDRPTF------------------------------------------------- -DYLRSVLED----------FFTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQPQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_musculus_ENSMUSP00000038838 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------MGCIKSKRKDNLNDDE-V----------DSKTQPVRNTDRTIY VRDPTS-NKQQRPV--PE----FHLLPGQRFQTKDPEEQG-DIVVALYPYDG-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IHPDDLSFKKGEK MKVLE--EHGEWWKAKS---------LSSKREGFIPSNYVAKVNTLETEE---------- ------------------------------------------------------------ ----------W------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------FFKDI------- ------------------------------------------------------------ --------------TRKDAERQ-LLA---------------------------------- -------------------------------------------------PGNSAGAFLIR ESET-----------------------------LKGSFSLSVRDYDPMHG-DVIKHYKIR SLDNGG------------YYISPRITFPCISDM---IKHYQ--------KQSDGLCRRLE KAC------------------ISPKPQK------P---WDKDAWEIPRESI-KLVKKLGA GQ-------FGEVWMGYYNN------STKVAVKTLK-PGTMS----VQ--A-FLEEANLM KTLQHDKLVRLYAVVTKEE-P-----IYIITEFMAKGSLLDFLKS--------DEGGKVL LPKLIDFSA-QIAEGMAYIERKN--YIHRDLRAANVLVSESLMCKIADFGLARVIEDNE- YTAREGA-----------------KFPIKWTAPEAINFG----C-FTIKSDVWSFGILLY EIV-TYGKIPYP---GRTNADVMSALSQGY-RMP-----RMENCPDE-----LYDIMKMC WKEKAEERPTF------------------------------------------------- -DYLQSVLDD----------FYTATEG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QYQQQP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_pygmaeus_ENSPPYP00000007720 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH ILLIS------KAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYN YALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKP PK-ECGDLCPGTM-EEKPMCEKTTINNEYNYRCWT----------TNRCQKMCPSACGK- RACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDF CANI----LSAESSDSEGFVIHDGECMQECPSGFIRNGSQ----SMYCIPCEGPCPKVCE EEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHS HALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPK LCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYR PPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPN----KDVE--PGIL ---LHGLKP-WTQYAVYVKAVTLTMVEND-------HIRGAKSEILYIRTNASVPSIPLD VLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD---KIPIRKY ADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAE-YRKVFENFLHNS IFVPR------------PERKRRDV-MQVANT----TM--SSRSRNTTAADTY-NITDPE ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEK----------------- --LGCSASKFVFARTMPA---EGADDIPGPVTWE--PRPENSIFLKWPEPENPNGLILMY EIKY-GSQVE-DQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFY VQAKTG--YENFIHLIIALPVAVLLIVGGLVIMLY-VFHRK--------RNNSRLGNGVL YASVNP---------------EYFSAAD------V---YVPDEWEVAREKI-TMSRELGQ GS-------FGMVYEGVAKGVVKDEPETRVAIKTVN-EAASM----RERIE-FLNEASVM KEFNCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS LSKMIQMAG-EIADGMAYLNANK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMSPESLKDG----V-FTTYSDVWSFGVVLW EIA-TLAEQPYQ---GLSNEQVLRFVMEGG-LLD-----KPDNCPDM-----LFELMRMC WQYNPKMRPAF------------------------------------------------- -LEIISSIKDEMEPGFREVSFYYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KLPEPEELDLE-PENMESVPLDPSASSSSLPL----- ----------------------------------------------------------PD RHS-GHKAEN-------------------------------------------------- ------------------------------------------------------------ -----------------------------------------GPGPGVLVLRASFDERQPY AHMNGGRKNERALPLPQSSTC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >T_nigroviridis_ENSTNIP00000010646 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MEPSA AM-------------------GCVNICS----------LTSSLPVIPYQKL-TDLYYLSR GG-------FGTVFKAQHSA-----WRTTVAIKC---LKLDSPVGERERNC-LLKEAEVL HKARFNHIIQILGICNEPE-F-----FCIVTEYMSNGSLDLLLHE-------KDIYPRLG WPLRLRILY-EISLGVNFLHNMNPPLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSV- --SRGSGSKPTE-----------MGGTVIYMPPERYDAS--KSHRADVKHDMYSYSIIMW EVL-S-RQIPFEASEVTNPMQIMFSVLNGA-RPEISLDSLPADIPSR---DTLICLMTTG WTSNPDERPSF------------------------------------------------- -LKCLVELEP----------MVRAYDE-----IDFLEAVLEIKR---------------- -----------------------SQLMRRSGCCAAQSDCQRSEG--GLHTLKDRPSPWQV SG-SSSGSGSGSSQDTNIS--LPGPLTITSPITGGYFCPLEDS---PG------------ -RLNKD-SCSDNQPN----SPW-LINDLNIPT-----KTKLP--------------DAED ESR--------LGNGSLKLQP--PPQV---PVAAYSPP-TQGPIAEWIASQREEIVAQM- -----------------------------------TEACLNQSLDALLARS----MLMRE DYEL---VKN----------------------------QQTRTAKVRQLLD--------- ---------NCH---------------------------------RHNEDFC--RIVVRK LHDN-----------------------KQMNLAPYPS----EITSPA----LASAPPVSM SYNITRNM---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >P_troglodytes_ENSPTRP00000042453 ------------------------------------------------------------ ------------------------------------------------------------ ----------MQG---HFPAERREGRPRRGTCGRQQLL--VSPRFLRAWHPPPVSARMPT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VFFC-LMDM---VEHYS--------KDKGAICTKLV RPKRKH---------------GTKSAEE------E---LARAGWLLNLQHL-TLGAQIGE GE-------FGAVLQGEYLG-------QKVAVKNIK--CDVT----AQ--A-FLDETAVM TKMQHENLVRLLGVILHQ--G-----LYIVMEHVSKGNLVNFLRT--------RGRALVN TAQLLQFSL-HVAEGMEYLESKK--LVHRDLAARNILVSEDLVAKVSDFGLAKA----E- RKGLDSS-----------------RLPVKWTAPEALKHG--------SKSDVWSFGVLLW EVF-SYDGAPYP---KMSLKEVSEAVEKGY-RME-----PPEGCPGP-----VHVLMSSC WEAEPARRPPF------------------------------------------------- -RKLAEKLAR----------ELRSAGA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PASVSGQDADGSTSPRS-QEP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >B_taurus_ENSBTAP00000003973 --------------------------PLVPTVC-PSLDIRSDVAELRRLENCSVVEGHLQ ILLMFTA----TGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGARLFLG YALVIFEMPHMRDVGLPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPSPGANHIVGNKL GE-ECADVCPGLLGTTGEPCARTTFSGHTDYRCWT----------SSHCQKVCP--CPRG LACTVRGECCHAECLGGCSRPEDPRACVACRHLYFQGACHRACPPGTYQHESWRCVTAER CASL-----RSVPGRASTFGIHQGSCLAQCPPGFTRNDS-----SIFCHKCEGLCPKECK --VGTKTIDSVQAAQDLVGCTHVEGSLILNLRQGYNLELELQRSLGLVETITGFLKIKHS FALVSLGFFKNLKLIRGDTMVDGNYTLYVLDNQNLQQLGSWVAAGLTIPVGKIYFAFNPR LCLEHIYRLEEVTGTKGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEANRILLRWERYE PLEARDLLSFIVYYKESPFQNATEYIGPDACGAQSWNLLDVELPLS----RTQE--PGVT ---LAPLKP-WTQYAVFVRAITLTTAEDS-------PHQGAQSPIVYLRTLPAAPTVPQD VISTSNSSSHLLVRWKPPTQRNGNITYYLVLWQRLAEDSDLYLNDYCHRG--LRLPTSNN DPRF-DGED------GELEADREPGCCPCQHPPPGQVLPPLEAQEAS-FQKKFENFLHNA ITIPKRV----------PDEPGRVV-SGLPRSPWKVTSINKSPQRDSGRSRRAAEALRLG GNSSDFKIQEDKV-PRERAVLSGLRHFTEYRIDIHACNHAAHT----------------- --VGCSAATFVFARTMPH---READGIPGKVAWE--AASKSSVLLRWLEPPDPNGLILKY EIKY-RRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFY IPGPEE-EDSGGLHVLLTVTPAGLMLLIILAVLGF-FYSKK--------RHSQTGRNSTL YASVNP---------------EYFSASH------M---YIPDEWEVPREQI-SIIRELGQ GS-------FGMVYEGLAQGLEVGEEPTPVALKTVN-ELASP----RERIE-FLKEASVM KAFKCHHVVRLLGVVSQGQ-P-----TLVIMELMTRGDLKSHLRSLRPEAENNPGLPRPA LGDMIQMAG-EIADGMAYLAANK--FVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETD- YY-RKGGK---------------GLLPVRWMAPESLKDG----I-FTTHSDVWSFGVVLW EIV-TLAEQPYQ---GLSNEQVLKFVVDGG-VLE-----ELESCPVQ-----LQELMQRC WQQNPRLRPTF------------------------------------------------- -THILDSIQEELRPSFRLLSFYHSPE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >M_domestica_ENSMODP00000032047 -------------------------------VC-PSMDIRNNLTQLNMLERCSVIEGSLQ ILLMFKT----KPEDFRDLSFPRLTMITEYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN YALVIFEMVHLKEIGLYNLMNITRGAVRIEKNNELCYLSTIDWSQILDSVEDNYIVDNKD GKEECGDVCPGAV-KGVNSCKSTVINGQFIERCWT----------HSHCQKVCPPSCKW- QGCTASGQCCHSECLGNCIEPNNPEKCVACRNFYLDGKCVETCPPNYYHFQDWRCVNFSV CQELHNKCKNSRQSSCSQYVIHNNKCIPECPSGYTMNSTN-----LHCSPCSGPCPKVCD -IVADQTIDSVHAAQALRGCTVINGSLIINIRGGNNIAAELEANLGLIEEITGYLKIRRS YALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITKGKLFFHYNPK LCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLRFSSIRTTHDKILLRWEPYW PPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVIDVEPPVRSNDPKTQNQHPGWL ---MRNLKP-WTQYAIFVKTLVT-FSDER-------RTYGAKSEIIYVQTNATVPSVPLD PISVSNSSSQIILKWKPPSEPNGNITHYLVYWEKQAEDVELYELDYCLKG--LKLPSRTW SPPF-ESEDSQKHNQSNHEDP-NGECCSC---PKTDSQILKELEESS-FRKTFENYLHNE VFIPRKASSGIGADDSRPSRRRRDLRFRVANV----TVVTPTGS----SFFNASSTTAPA STEEPKPFEKVK--SKESLVISGLQHFTGYRIELQACNHDEQE----------------- --SRCGLAAYVSARTMPEGKSASADDIVGAVTHE--VLEHNIVHLRWQEPKHPNGLIILY EVNYWRVGDTEELHLCVSRKHYANEQGCRLRGLQPGNYTVRIRATSLAGNGSWTEHTYFY VADYLD--VPSNIAKIIIGPVIIAIFLVSMVGAIY-VFVKK--------RQTEG-PTGPL FASSNP---------------EYLSASDGLHPSKL---YVPDEWEVAREKI-SLLRELGQ GS-------FGMVYEGNAKDIVKGEAETRVAVKTVN-ESASL----RERIE-FLNEASVM KGFSCHHVVRLLGVVSKGQ-P-----TLVVMELMVHGDLKSYLRSLRPEAENNPGRPPPT LREIIQMAV-EIADGMAYLNAKK--FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD- YY-RKGGK---------------GLLPVRWMAPESLKDG----V-FTTYSDVWSFGVVLW EIS-SLAEQPYQ---GLSNEQVLKFVMDGG-YLD-----QPDNCPER-----VNSLMQMC WQYNPKMRPTF------------------------------------------------- -IEIIEMLKDDLHPSFREVSFFYSEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KPPESEEFEMD-FENMESIPLDP---SSYSQR----- ----------------------------------------------------------DE VLG----RDN-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------GP-SLGLKGNYEERIPY THMNGGKKNGRILSLPRSNPS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------