10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 ------------------------------------------------MA------------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- P_troglodytes_ENSPTRP00000036949 ------------------------------------------------MA------------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- P_pygmaeus_ENSPPYP00000022191 ------------------------------------------------MA------------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- M_mulatta_ENSMMUP00000015132 ------------------------------------------------MA------------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACGNVLRR------- E_caballus_ENSECAP00000011150 ------------------------------------------------MA------------AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRR------- C_familiaris_ENSCAFP00000028895 ------------------------------------------------MA------------AASVTPPGSLDLLQP----------GFSKTLLGTKPEDKYLCSACRNVLRR------- M_musculus_ENSMUSP00000109872 ------------------------------------------------MA------------AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACKNILRR------- B_taurus_ENSBTAP00000013869 ------------------------------------------------MA------------AASVTPPGSLDLLQP----------GFSKTLLGTKLEDKYLCSACKNVLRR------- M_domestica_ENSMODP00000021625 ------------------------------------------------MA------------TANSTPPGSLDLLQP----------GFSKDILGTKLEDKYLCSACKNILRR------- G_gallus_ENSGALP00000014649 ------------------------------------------------MA------------AANSTPPGSLDLSQP----------GFAKEILGTKLEVKYLCSDCRNILRR------- R_norvegicus_ENSRNOP00000058607 ------------------------------------------------MA------------AASVTSPGSLELLQP----------GFSKTLLGTRLEAKYLCSACRNILRR------- G_gorilla_ENSGGOP00000006994 ------------------------------------------------MA------------AASVTPPGSLELLQP----------GFSKTLLGTKLEAKYLCSACRNVLRR------- T_nigroviridis_ENSTNIP00000016461 ------------------------------------------------MA------------AQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- T_guttata_ENSTGUP00000002510 ------------------------------------------------MA------------AANSSPPGSLDLNQP----------GFAKEILGTKLEVKYLCSDCKNILRR------- G_aculeatus_ENSGACP00000006974 ------------------------------------------------MA------------AQEQSPPSSLEGNKP----------GFPKKILANSLEDKHLCNSCQKVLRR------- O_latipes_ENSORLP00000003220 ------------------------------------------------MA------------ALEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- T_rubripes_ENSTRUP00000011363 --------------------------------------------------------------SQEPSPPSSLEGNKP----------GFPKKILANNLENKHLCKSCQKVLRR------- O_latipes_ENSORLP00000020860 --------------------------------------------------------------QQEPSPPSSLEGSKP----------GFPRKILANCLEDKHLCNSCEKILRR------- T_rubripes_ENSTRUP00000015632 ---------------------------------------------TDAMA------------TQEPSPPSSMESNKP----------GFPKKILGNKLEDKHLCNCCHNILRR------- T_nigroviridis_ENSTNIP00000013509 ------------------------------------------------MA------------SQEPSPPSSLEGNKP----------GFPRKILANNLESKHLCKSCQKVLRR------- D_rerio_ENSDARP00000043465 --------------------------------------------------------------AQEPSPPSSLEGNKP----------GFPKKILANKLEDKHLCNICLKILRR------- D_rerio_ENSDARP00000069217 -------------------------------------------------MISAAGTLCKWKDMERPSLPSSLDSTLP----------GISREVLSVSMEPKYQCQQCKDILRK------- X_tropicalis_ENSXETP00000008559 ------------------------------------------------AA------------AVSGSPQGSLDLNQP----------GFKKEILGTKLEVKYLCSDCKNLLRR------- G_aculeatus_ENSGACP00000020860 ------------------------------------------------MA------------TQEPSPPSSMESNKP----------GFPKKILGNQLEDKHLCNCCHNILRR------- T_nigroviridis_ENSTNIP00000011878 --------------------------------------------------------------MARISLDCS--PSLP----------GIPLSVLSVPMENKYKCQQCLQVLRK------- T_rubripes_ENSTRUP00000047803 --------------------------------------------------------------MARISMDCS--SSLP----------GIPLSVLSVPMENKYKCQQCLQVLRK------- O_latipes_ENSORLP00000008989 --------------------------------------------------------------MARISWDSL--SSLP----------GIPLSVLSVPMEDKYKCQQCLQVLRK------- G_aculeatus_ENSGACP00000022084 --------------------------------------------------------------MARISLDCP--VSLP----------GIPLSVLSVPMENKYKCQQCLLVLRK------- A_carolinensis_ENSACAP00000006987 -------------------------------------------------A------------SANVTPPGSLDEDQV----------GFPKEILGTELEGKYLCSECGNILRR------- G_gallus_ENSGALP00000002401 ------------------------------------------------------------PRAGPAGGPGADAAVLP----------GGSRRGVGDVPEQKYLCSNCNNVLKK------- T_guttata_ENSTGUP00000006737 -----------------------------------------------------------------------------------------------DVPGHKFLCSNCNNILKK------- D_rerio_ENSDARP00000091948 -------------------------------------------------------------SGSASDPSLNGVSSTP----------GFPQSICDEVPKDKYLCSNCNNVLNK------- O_anatinus_ENSOANP00000001757 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013348 -----------------------MSAGRSTDGREVQIPLQQAAPSLAMPLSVA--------PLLTSHCVPAGFLPLH----------GGFRDHFVEALEAKYCCESCRLVLCQ------- T_nigroviridis_ENSTNIP00000005138 -----------------------------------------------------------------PAGGPAGFQPLH----------GGFRDHFVEAPEAKYCCESCRLVLCQ------- G_aculeatus_ENSGACP00000005703 -------------------------------GGRCRFPLQQVAPSLTPALSVASPVHRQVNPWPPSDTTPQRFLPLH----------KGFRDHFALTPEAKYCCETCSLVLCQ------- X_tropicalis_ENSXETP00000027864 -----------------------MDTGKKTDPSASV-----QK------------------ANPDRSLATTIYVPEQ----------GGYKERFLKPVEEKYKCEKCRLVLCN------- E_caballus_ENSECAP00000011833 -----------------------MESSKKMDSPGALQTNPPLK------------------LHPDRSTSTAVFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCN------- D_rerio_ENSDARP00000038596 -----------------------MSAGRNV---EQQIPLQQRPPSLAMP------------SMAQRPRPEPGFSPLH----------GGFRDHFVTTPEPKYCCETCRLVLCN------- P_pygmaeus_ENSPPYP00000007003 -----------------------MESSKKMDSPGALQTNPPLK------------------LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCS------- P_troglodytes_ENSPTRP00000003288 -------------------------------------------------MAYSEEHKGMPCGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- C_familiaris_ENSCAFP00000026713 -----------------------MESSKKMDSPGTLQTNPPLK------------------LHPDRSAGTSIFVPEQ----------GGYKERFVKTVEDKYKCEKCRLVLCN------- A_carolinensis_ENSACAP00000000193 -----------------------MDTSKKTDPPVSVETV-QQK------------------ANVERSPVPSVYIPEQ----------GGYKEKFVNAVEDKYKCEKCRLILCN------- P_troglodytes_ENSPTRP00000011503 -----------------------MESSKKMDSPGALQTNPPLK------------------LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCS------- M_mulatta_ENSMMUP00000038268 -------------------------------------------------MAYSEEHRGMPCGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCRSVLHN------- M_musculus_ENSMUSP00000021706 -----------------------MESSKKMDAAGTLQPNPPLK------------------LQPDRGAG-SVLVPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCN------- P_pygmaeus_ENSPPYP00000000253 -------------------------------------------------MAYSEEHKGMPCGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- R_norvegicus_ENSRNOP00000010906 -----------------------MEPSKKMGAAGAAQPNPPLK------------------LQPDRGAA-SVLVPEQ----------GGYKEKFAKTVEDKYKCEKCRLVLCN------- G_gallus_ENSGALP00000036699 ------------------------------------------R------------------ANPDRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHFILCN------- O_anatinus_ENSOANP00000023053 -----------------------MDSSKKMDPS-LVQQNVPPK------------------GNPDRGPGASIYVPEQ----------GGYKERFVKTVEDKYKCEKCHLILCN------- H_sapiens_ENSP00000376500 -----------------------MESSKKMDSPGALQTNPPLK------------------LHTDRSAGTPVFVPEQ----------GGYKEKFVKTVEDKYKCEKCHLVLCS------- H_sapiens_ENSP00000336825 -------------------------------------------------MAYSEEHKGMPCGFIRQNSGNSISLDFE----------PSIEYQFVERLEERYKCAFCHSVLHN------- T_guttata_ENSTGUP00000013203 ------------------------------------------R------------------ANPDRSPSASIYVPEQ----------GGYKEKFVNAVEDKYKCEKCHLILCN------- B_taurus_ENSBTAP00000017918 -----------------------MEPSKKLDAAGALPANPPLK------------------LHPERGAGPAVLVPEQ----------GGYKERFVKAVEDKYKCEKCRLVLCS------- M_domestica_ENSMODP00000024498 ---------------------------------------------------------LTDTAPVGPHLIPDENEFPF----------GYPASICQGTPEPKYLCCGCHNVLKK------- O_anatinus_ENSOANP00000013484 -------------------------------------------------SMGSEELTIGSRAFSHQNSSSCISLDFE----------PDIQYQFVEQLEERYKCTFCHSVLHN------- M_domestica_ENSMODP00000016701 -----------------------MDSSKKMDPPNPLQTV-QQK------------------ANPDRGAAVSIYVPEQ----------GGYKEKFVKPVEDKYKCEKCHLILCN------- E_caballus_ENSECAP00000005414 -------------------------------------------------MAYSEEQGGVPCGFIRQNSSNSVSLDFE----------PNTEYRFVEQLEERYKCAFCHSVLHN------- T_guttata_ENSTGUP00000003276 --------------------------------------------------MACDEPAALSGIFTRQNSSSTSSLDFE----------PHADYRFVESLEERYKCAYCHLVLRN------- G_gallus_ENSGALP00000016021 --------------------------------------------------MACDELTGVSGIFTRQNSASAVSLDFE----------PDTDYKFVETLEDRYKCAYCHSVLHN------- A_carolinensis_ENSACAP00000016112 -------------------------------------------------MASEDLACQVPNFYIRQNSTNAVSLDFE----------PDASYQFVEILEDRYKCTHCHLVLHN------- B_taurus_ENSBTAP00000015940 -------------------------------------------------MAYFEEQGGVPCGFTRQNSGNSISLDFE----------PDAEYQFVERLEERYKCAFCHSVLHN------- P_troglodytes_ENSPTRP00000036416 ---------------------------------------------------------MASSSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- H_sapiens_ENSP00000362994 ---------------------------------------------------------MASSSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- M_domestica_ENSMODP00000003305 -------------------------------------------------SLTSAEYGSASGDFLPQNSSSYISLDFE----------PNIDYQFVEQLEERYKCASCHSVLHN------- M_musculus_ENSMUSP00000082710 -------------------------------------------------MAHSEEQAAVPCAFIRQNSGNSISLDFE----------PDTEYQFVEQLEERYKCAFCHSVLHN------- M_mulatta_ENSMMUP00000026496 ---------------------------------------------------------MASSSGSSPRPAPDENEFPF----------GCPPTVCRDPKEPRALC---------------- M_musculus_ENSMUSP00000028234 ---------------------------------------------------------MASSS------APDENEFQF----------GCPPAPCQDPSEPRVLC---------------- C_familiaris_ENSCAFP00000017853 -------------------------------------------------MAYSEDQGGVPCGFIRQNSSNSISLDFE----------PHTEYRFVEPLEERYKCALCHSVLHN------- O_cuniculus_ENSOCUP00000007884 -------------------------------------------------MAYSEEPGGIHLGFIRQNSGSSISLDFE----------PNAEYRFVEQLEERYKCAFCHSVLHN------- P_pygmaeus_ENSPPYP00000021917 ---------------------------------------------------------MASSSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- E_caballus_ENSECAP00000009372 ---------------------------------------------------------MASGSASSPRPAPDENEFPF----------GCPPTVCEDPSEPRALC---------------- M_mulatta_ENSMMUP00000015419 -----------------------MESSKKMDSPGPLQTNPPLK------------------LHTDRSAGTPIFAPEQ----------GGYKEKFVKTVEDKYKCEKCRLVLCS------- O_cuniculus_ENSOCUP00000004916 ---------------------------------------------------------MASSSASSPRPAPDENEFPF----------GCPPSAFQDPAEPRALC---------------- B_taurus_ENSBTAP00000041215 ---------------------------------------------------------MASGSASSPRPAPDENEFPF----------GCPPTACQDPPEPGPVC---------------- G_gorilla_ENSGGOP00000002249 ---------------------------------------------------------MASSSGSSPRPAPDENEFPF----------GCPPTVCQDPKEPRALC---------------- X_tropicalis_ENSXETP00000031605 -------------------------------------------------IMACEDLCPLPVTLGRQNSSAAVSLDFV----------PKQEYLFVEQLQDRYKCASCHLVLHN------- C_intestinalis_ENSCINP00000001022 -----------------------MDTAD-------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000027890 -----------------------M------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000001432 -----------------------M------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 ---------------------------------------------------------------------LAGRLQTH----------GVVRNHFVMKLKEEFICPICKGVVLN------- C_intestinalis_ENSCINP00000005981 -----------------------M------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004192 -----------------------MESSKKMDSPGALQTNPPLK------------------LHTDRSAGTPVFVPEQ----------GGYKEKXXXXXXXXXXXXXXXXXXXX------- C_familiaris_ENSCAFP00000031262 ---------------------------------------------------------MASGSASSPRPAPDENEFPF----------GCPPDACQEPAEPRAVR---------------- O_cuniculus_ENSOCUP00000003184 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024090 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCAKAMRE------- D_rerio_ENSDARP00000013849 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- H_sapiens_ENSP00000262395 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- G_aculeatus_ENSGACP00000014759 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- B_taurus_ENSBTAP00000050075 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- M_musculus_ENSMUSP00000017530 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- R_norvegicus_ENSRNOP00000018468 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- G_gallus_ENSGALP00000012873 ----------------MSLLHSDSSCGGRDLDSGCCTAM-ASACSGGAKED--S---VSVGS--GTGNPPSSFTEET----------QGYDVEFDPPLESKYECPICLMALRE------- R_norvegicus_ENSRNOP00000006148 ----------------MSLLNCENSCASSQSSSDCCAAM-ANSCSAAMKDD--S---VSGCV--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- O_latipes_ENSORLP00000005579 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- D_rerio_ENSDARP00000014326 -------------------------------------------------------------------------------------------------LEQQFICPSCGGIVLN------- T_guttata_ENSTGUP00000010462 ----------------MSLLHSDSSCGGRDAESGCCAAM-ASACSAAAKEE--S---SSVGS--AVGTAPGSFGEET----------QGYDVEFDPPLESKYECPICLMALRE------- T_rubripes_ENSTRUP00000012878 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRFQCPLCSKAMRE------- M_musculus_ENSMUSP00000004949 ----------------MSLLNCENSCGSSQSSSDCCAAM-AASCSAAVKDD--S---VSGSA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- A_carolinensis_ENSACAP00000005007 ----------------MSLLHSNTSFETNSQESGCCAAM-ASACSAAAKEE--SINASVSNE--TGGTLSNSFMEET----------QGYDVEFDPPLESKYECPICLMALRE------- M_mulatta_ENSMMUP00000021907 MYILKERIRASDNQVTMSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALRE------- O_anatinus_ENSOANP00000018657 ----------------MSLLNCENSCGASQSEGDCCAAM-ASACSAGAKDD--S---VSSSV--NTGNLHNSFMAET----------QGYDVEFDPPLESKYECPICLMALRE------- P_pygmaeus_ENSPPYP00000003845 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- P_troglodytes_ENSPTRP00000006096 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- B_taurus_ENSBTAP00000021630 ----------------MSLLHCENSCGSSQSESDCCAAMAASSCGTAAKDD--S---VSGTA--STVTLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- H_sapiens_ENSP00000316840 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAVTKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- G_aculeatus_ENSGACP00000025883 --------------------------------------------------------------------------------------------KFVSPLREEFVCPVCGGVVLN------- M_domestica_ENSMODP00000024756 ----------------MSLLNCEDSCGTSHPESDCCAGV-ASACSTGTKDD--S---VNGST--IPGNLPSSLREEI----------QGYDVEFDPPLESKYECPICLMALRE------- D_rerio_ENSDARP00000056877 --------------------------------------------------------------------------------------MPGLDLKFLERPRRKFYCPLCEKPMRE------- C_familiaris_ENSCAFP00000010159 ----------------MSLLNCENSCGSSQSESDCCPAM-ASSCSAAVKDD--S---VSGTT--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- G_aculeatus_ENSGACP00000022648 -------MASAE-SGKGSLQEDSYEGPVGGELSGCALAM-MEKERESLLSP--S---ESPGTFISGSSASLQAPAPL----------QGYDVEFDPPLESKYECPICLMALRN------- T_rubripes_ENSTRUP00000041697 -------MACFD-SSKESL-EDSFDGAAGGKLSGCALAM-SEKERESLLNP--S---ESPSTYMSGASSSFQDATHQ----------QGYDVEFDPPLESKYECPICLMALRN------- X_tropicalis_ENSXETP00000042386 ---------------------------------------------------------------ANLSSVPVENEFVF----------GYPTTICDVAPGEKYLCCSCNSVSLN------- T_nigroviridis_ENSTNIP00000012472 -------MACFDSSSKGSLEEDSCDGAIGGELSGCALVM-MEKEQESLLSP--S---ESPGTYMSGASSSFHDGTHQ----------QGYDVEFDPPLESKYECPICLMALRN------- M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036715 -------MACND-VDKSSFDDVCCD----SGHSSCA-AA-MEKERESFLSP--T---ENPSTI----SVSSSMPPDQ----------QGYDVEFDPPLESKYECPICLMGLRS------- E_caballus_ENSECAP00000009502 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000016445 ----------------MSILNCRPSFDGVDTDDACCGAM-ASACCVNTKEDGES---PSAGS--PSGTPQSLVLEDV----------QGYDVEFDPPLESKYECPICLMALRE------- B_taurus_ENSBTAP00000016271 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001290 --------------------------ASGGGLSECASAM-LEKERESLPSP--S---DNPTA--SMGSSSLQAAAPL----------QGYDVEFDPPLESKYECPICLMALRN------- G_gorilla_ENSGGOP00000016344 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018618 ----------------MSLLNCENSCGSSQTESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSSSFMEDI----------QGYDVEFDPPLESKYECPICLMALRE------- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000748 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- M_mulatta_ENSMMUP00000021905 -------------------LNCENGCGSSQSESDYCVAM-ASSCSAATKDD--S---VGGTA--SMGNLSSSFMEEI----------QGYDVEFDPPLESRYECPICLTALRE------- C_intestinalis_ENSCINP00000003738 -------------------------------------------------------------------------------------------------------CVECKYTLEF------- O_anatinus_ENSOANP00000028670 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010330 ----------------MSLLNCENSCGSGQSESDCCAAM-ASSCSAAAKDD--S---VSGTA--STGNLSGSFVEDI----------QGYDVEFDPPLESKYECPICLMALRE------- C_elegans_F45G2.6 --------------------------------------------------------------------------------------MTSQSVMFKGGLPADCTCPICEQALRD------- D_melanogaster_FBpp0111838 -----------------MPAPPATVKPATGHTTKLNNGKSSNSNSNHTLSNSIAHLSDSRTNLTVNTPTTCQRLSEMFRRSIASSTQSSSRENTYEEWTKTLSFPSRLSPNRNSKDCSTL A_gambiae_AGAP010017-PA ------------------------------------------------------------------------------------------MVRSLSQWTKTLSFPARISPNRNSKDCNVN O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006649-PA ------------------------------------------------------------------------------------------MVRSLSQWTKTLSFPARISPNRNSKECSVN C_familiaris_ENSCAFP00000027741 --------------------------------------------------------------------------------------MPGFDYKFLEKPKRRLLCPLCGKPMRE------- C_intestinalis_ENSCINP00000008928 --------------------------------------------------------------------------------------MPGYQNKFVDKVRKRHQCPLCHFPMRD------- G_gorilla_ENSGGOP00000012479 -------------------------------------------------MAYSEEHKGVPCGFIRQNSGNSISLDFE----------PNIEYQFVERLEERYKCAFCHSVLHN------- O_latipes_ENSORLP00000024257 -----------------------MSAGRSADGREVQIPLQQAAPSLALP------------LSAAVPAPPPGFLPVR----------GGFRDHFVEAPEAKYCCEACRLVLCQ------- G_gorilla_ENSGGOP00000005734 ----------------MSLLNCENSCGSSQSESDCCVAM-ASSCSAATKDD--S---VGGTA--STGNLSSSFMEEI----------QGYDVEFDPPLESKYECPICLMALRE------- A_gambiae_AGAP003004-PA -------------------------------------------------------------------------------------FLQSAAKADDGVLEARYECPICYCWLNE------- D_rerio_ENSDARP00000040549 -----------------------------------------------------MAAEENESSGLSRQNSEASRSWDL----------DSRTLRFVSRLEQQFICPSCGGIVLN------- D_melanogaster_FBpp0074051 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL015342-PA ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL011363-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071136 MQRVQADQKPARMHQHAHTHSHAHSLQHAEEKEHNSNEMTTNLSSTGRIAASSSATPSAAAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNE------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- P_troglodytes_ENSPTRP00000036949 ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- P_pygmaeus_ENSPPYP00000022191 ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- M_mulatta_ENSMMUP00000015132 ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPIDG--CTWKGTLKEYEVKMP E_caballus_ENSECAP00000011150 ----------PFQAQ--------CGHRYCSYCLTSIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPSDG--CTWKGTLKEYE---- C_familiaris_ENSCAFP00000028895 ----------PFQAQ--------CGHRYCSYCLSSIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNNG--CTWKGTLKEYE---- M_musculus_ENSMUSP00000109872 ----------PFQAQ--------CGHRYCSFCLTSILRCASILSSSGP---QNCA---ACVYEGL-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE---- B_taurus_ENSBTAP00000013869 ----------PFQAQ--------CGHRYCSFCLSSIL-------SSGP---QSCA---ACVHEGI-YEEGVSIL-ESSS--AFPDNAARREVESLPAVCPSEG--CSWKGTLKDYE---- M_domestica_ENSMODP00000021625 ----------PFQAQ--------CGHRYCSYCLTSII-------STGP---QNCA---ACIQEGI-YEEGISIL-ESSS--AFPDNAARREVESLPAVCVNDG--CTWKGTIKEYE---- G_gallus_ENSGALP00000014649 ----------PFQAQ--------CGHRYCSYCLKKII-------SSGP---QKCA---SCIQEGI-YEEGISIL-ETSS--AFPDNAARREVESLPAVCINEG--CTWKGTIKEYE---- R_norvegicus_ENSRNOP00000058607 ----------PFQAQ--------CGHRYCSFCLTSILRSQSAHSSSGP---QNCA---ACVHEGL-YEEGISIL-ESSS--AFPDNAARREVESLPAVCPNDG--CTWKGTLKEYE---- G_gorilla_ENSGGOP00000006994 ----------PFQAQ--------CGHRYCSFCLASIL-------SSGP---QNCA---ACVHEGI-YEEGISIL-ESSS--XXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXX---- T_nigroviridis_ENSTNIP00000016461 ----------PFQAQ--------CGHRFCSYCFTRTV-------SNGP---QKCS---ACIKEDI-FEDPTSIL-KQGC--AFPDNAVRREVEHLPAVCINEN--CTWKGTIKEYE---- T_guttata_ENSTGUP00000002510 ----------PFQAQ--------CGHRYCSYCLKKII-------SAGP---QKCA---SCIQEGI-YEEGISIL-ETSS--AFPDNAARREVESLPAVCINSG--CNWKGTIKEYE---- G_aculeatus_ENSGACP00000006974 ----------PLQAQ--------CGHRFCSFCFNKIV-------SSGP---QKCS---ACIKEDL-FEDPTSIL-KQGG--AFPDNAARREVEALAAVCPNEE--CTWTGTIKEFE---- O_latipes_ENSORLP00000003220 ----------PIQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCN---ACIKEEI-FEEPTSIL-KQGC--AFPDNAVRREVEGLSADCINEN--CPWKGTIKEYE---- T_rubripes_ENSTRUP00000011363 ----------PLQAQ--------CGHRFCSFCFHKIV-------SAGP---QTCS---ACISEDL-FEEPASIL-KLGG--AFPDNAARREVEALAAVCPNEG--CIWTGTIKEFE---- O_latipes_ENSORLP00000020860 ----------PLQAQ--------CGHRFCCFCFNRTV-------SSGP---QKCS---ACIKEDL-FEEPTSIL-KQGG--AFHDNAARREVEALAAVCPNEG--CTWTGTVKEYE---- T_rubripes_ENSTRUP00000015632 ----------PFQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCS---ACIKRIL-WFQ------------AFPDNAVRREVEHLPAACINEN--CTWKGTIKEYE---- T_nigroviridis_ENSTNIP00000013509 ----------PLQAQ--------CGHRFCCFCFRKIV-------SAGP---QTCR---ACISEDL-FEEPASIL-KSGG--AFPDNAARREVEALAAVCPNEG--CTWTGTIKEFE---- D_rerio_ENSDARP00000043465 ----------PFQAQ--------CGHRFCSYCFNKAV-------SKDK---KVCT---TVV----------IMK-KKKK--AFPDNAAKREVEALEAVCINEE--CSWTGTIKEYE---- D_rerio_ENSDARP00000069217 ----------PFQAQ--------CGHRFCVFCFKQLT-------SSGP---IPCE---ACRAEGI-FEEETSVL-NIAV--AFPDNAARREIDSLPAKCPNEG--CSWSGTLKDFE---- X_tropicalis_ENSXETP00000008559 ----------PLQAQ--------CGHRYCSHCLNKII-------STGP---QKCS---ACIQEGI-WHQTVCIV-SDWG--GQPGNV--RGVGGGSSVILGGGMYCVLNPTHQSGR---- G_aculeatus_ENSGACP00000020860 ----------PFQAQ--------CGHRFCSYCFNRTV-------SNGP---QKCS---ACIKEDL-FEDPTSIL-KPGC--AFPDNAVRREVENLSAVCIHEH--CSWKGSIKDYE---- T_nigroviridis_ENSTNIP00000011878 ----------PVQAQ--------CGHRFCVHCFRELT-------SSGP---KPCE---ACRQEEI-YEEPTSIL-NSNE--VFPDNAAGREIASLPARCLNQD--CSWTGSIKQYE---- T_rubripes_ENSTRUP00000047803 ----------PVQAQ--------CGHRFCIHCFKELT-------SSGP---KPCE---ACRQEEI-YEEPISVL-NSNE--VFPDNAAGREIASLPARCLNQG--CSWTGSIKQYE---- O_latipes_ENSORLP00000008989 ----------PVQAQ--------CGHRFCVHCFRQLT-------SSGP---KPCQ---ACRKEEI-YEEPMSIL-NSSE--AFPDNAAGREIASLPARCLNQG--CDWTGSIKEYE---- G_aculeatus_ENSGACP00000022084 ----------PVQAQ--------CGHRFCVHCFRQLT-------SYGP---KPCD---ACRQEEI-YEEPISIL-NSNE--AFPDNAAGREIASLPAKCLNQG--CDWTGSIKEYE---- A_carolinensis_ENSACAP00000006987 ----------PFQAQ--------CGHRYCASCLQRLI-------SSGP---QKCG---ACIQEGI-YEDGVSIL-ETGS--AFPDNAARREVESLPAICANEG--CAWKGTIKEYE---- G_gallus_ENSGALP00000002401 ----------ALQTL--------CGHRYCSACLSWIV-------RNNK--NPVCQ---KCKEEDPSTLSEGSLL-AEER--AFGDAAINKEISELRVHCVTLG--CSWCGTMKNFE---- T_guttata_ENSTGUP00000006737 ----------ALQTL--------CGHRYCSACLAWIL-------RNNK--NAICQ---KCKEEDPNTLGEESLL-AEER--AFGDAAINKEISELRVHCVTLG--CSWSGIMKDFE---- D_rerio_ENSDARP00000091948 ----------ARQTV--------CGHRYCLACVNWLV-------RNNK--DLVCT---KCKGEDSNVESDTSVL-TPNQ--FFNDVAINKEILDLKVHCANQG--CPWRSTLKNFE---- O_anatinus_ENSOANP00000001757 ---------------------------------------------------------------------------------AFSDAAINKEISELNVHCVTPG--CSWTGLMKNFE---- T_rubripes_ENSTRUP00000013348 ----------PRQTE--------CGHRFCQSCINDIL-------SHPN---PVCP---ADTEP----------L-FKDK--VFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP---- T_nigroviridis_ENSTNIP00000005138 ----------PRQTE--------CGHRFCQSCITQLL-------GHAN---PVCP---ADMEP----------L-FKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMRLQQIP---- G_aculeatus_ENSGACP00000005703 ----------PRQTE--------CGHRFCQSCINDIL-------SHPN---PVCP---ADMEP----------L-FKDK--IFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIP---- X_tropicalis_ENSXETP00000027864 ----------PRQTE--------CGHRFCETCMNAIL-------SSTS---PQCM---ACEDN----------I-TKDK--VFKDNCCRREVLALQMFCRNETRGCKELITLGNLL---- E_caballus_ENSECAP00000011833 ----------PKQTE--------CGHRFCETCMAALL-------SSSS---PKCT---ACQEG----------I-IKDK--VFKDNCCKREILALQIYCRNESRGCVEQLTLGHLL---- D_rerio_ENSDARP00000038596 ----------PRQTE--------CGHRFCESCINELL-------SKPN---PVCP---ADLLP----------L-FEDK--IFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVM---- P_pygmaeus_ENSPPYP00000007003 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- P_troglodytes_ENSPTRP00000003288 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- C_familiaris_ENSCAFP00000026713 ----------PKQTE--------CGHRFCETCMAAVL-------SSSS---PKCT---ACQES----------I-IKDK--VFKDNCCKREILALQIYCRNEGGGCTEQLTLGHLL---- A_carolinensis_ENSACAP00000000193 ----------PRQTE--------CGHRYCETCMNALL-------SCTI---PKCT---ACQET----------I-VKEK--IFKDNCCRRELLALQIFCRNENKGCREQLTLGQLL---- P_troglodytes_ENSPTRP00000011503 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- M_mulatta_ENSMMUP00000038268 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- M_musculus_ENSMUSP00000021706 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------I-IKDK--VFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLL---- P_pygmaeus_ENSPPYP00000000253 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- R_norvegicus_ENSRNOP00000010906 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------I-IKDK--VFKDNCCKREILALQIYCRNEGRGCVEQLTLGHLL---- G_gallus_ENSGALP00000036699 ----------PKQTE--------CGHRFCETCMNALL-------STPS---PKCT---ACQES----------I-VKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL---- O_anatinus_ENSOANP00000023053 ----------PKQTE--------CGHRFCETCMNMLL-------SSSS---PKCS---ACQEN----------V-IKDK--VFKDNCCKREILALQIYCRNENRGCTEQLTLGHLL---- H_sapiens_ENSP00000376500 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLMLGHLL---- H_sapiens_ENSP00000336825 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- T_guttata_ENSTGUP00000013203 ----------PKQTE--------CGHRFCETCMNALL-------RSSS---PKCT---ACQES----------I-VKDK--VFKDNCCRRELLALQIYCRNENKGCKEQLSLGQLL---- B_taurus_ENSBTAP00000017918 ----------PKQTE--------CGHRFCETCMGALL-------SSSS---PKCT---ACQEV----------I-IKDK--VFKDNCCKREILALQIFCRNEGRGCTEQLALGHLL---- M_domestica_ENSMODP00000024498 ----------AQQTL--------CGHRYCAACLSWIL-------SSPN------------------------------------------------------------------------ O_anatinus_ENSOANP00000013484 ----------PHQTS--------CGHRFCQHCILSLR-------ELNN--FPTCP---IDKKI----------I-QLQE--VFKDNCCKREVLNLQVFCKN-APGCNSKMILGRYQ---- M_domestica_ENSMODP00000016701 ----------PKQTE--------CGHRFCETCMHVLL-------SAPS---PKCT---ACQEN----------I-IKDK--VFKDNCCKREILALQIYCRNESRGCTEQLTLGHLL---- E_caballus_ENSECAP00000005414 ----------PHQTG--------CGHRFCQHCILSLR-------ELNA--VPLCP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ---- T_guttata_ENSTGUP00000003276 ----------PHQTG--------CGHRFCQQCILALR-------ELNA--VPTCP---VDKET----------I-KMHE--VFKDNCCKREVLNLHVFCKN-FPDCSSKVILGRYQ---- G_gallus_ENSGALP00000016021 ----------PHQTG--------CGHRFCQQCILTLR-------GLNA--VPTCP---VDKET----------I-KMHE--VFKDNCCKREVLNLYVFCKN-LPDCNSKIILGRYQ---- A_carolinensis_ENSACAP00000016112 ----------PHQTG--------CGHRFCQRCIASLR-------ELSV--IPTCP---VDKEI----------I-KPHE--VFKDNCCKREVLNLQVYCRN-SPACNAKTSLGRYQ---- B_taurus_ENSBTAP00000015940 ----------PHQTG--------CGHRFCHQCILALR-------ELDT--VPLCP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVFCKN-APRCNAKIILGRYQ---- P_troglodytes_ENSPTRP00000036416 ----------------------------CAGCLSENP-------RNGE------------------------------------------------------------------------ H_sapiens_ENSP00000362994 ----------------------------CAGCLSENP-------RNGE------------------------------------------------------------------------ M_domestica_ENSMODP00000003305 ----------PHQTG--------CGHRFCENCILSLR-------ELNT--VSICP---VDKEI----------I-KPKE--VFKDNCCKREVLNLQVFCKN-APHCAAKMILGRYQ---- M_musculus_ENSMUSP00000082710 ----------PHQTG--------CGHRFCQQCIRSLR-------ELNS--VPICP---VDKEV----------I-KPQE--VFKDNCCKREVLNLHVYCKN-APGCNARIILGRFQ---- M_mulatta_ENSMMUP00000026496 ----------------------------CTGCLSENL-------RNSE------------------------------------------------------------------------ M_musculus_ENSMUSP00000028234 ----------------------------CTACLSENL-------RDDE------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017853 ----------PHQTG--------CGHRFCQHCILSLR-------ELNA--VPLCP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCKN-APGCNAKIILGRYQ---- O_cuniculus_ENSOCUP00000007884 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-RSQE--VFKDNCCKREVLNLHVYCKN-APGCNAKVILGRYQ---- P_pygmaeus_ENSPPYP00000021917 ----------------------------CTGCLSENP-------RNGE------------------------------------------------------------------------ E_caballus_ENSECAP00000009372 ----------------------------CAACLSENS-------RNGE------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 ----------PKQTE--------CGHRFCESCMAALL-------SSSS---PKCT---ACQES----------V-VRDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- O_cuniculus_ENSOCUP00000004916 ----------------------------CTACLSE-L-------RNCE------------------------------------------------------------------------ B_taurus_ENSBTAP00000041215 ----------------------------CAVCLSEKV-------RNDE------------------------------------------------------------------------ G_gorilla_ENSGGOP00000002249 ----------------------------CAGCLSENP-------RNGE------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 ----------PHQTG--------CGHRFCEKCISNLI-------ELSE--TPQCP---IDMEN----------I-KSHE--IFKDNCCKREVLNLLVYCKN-SPACDVKVMLGRYQ---- C_intestinalis_ENSCINP00000001022 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 ----------PQQNS--------CGHIYCFHCLQGLL-------ESSLLSGPVCP---VEKAA----------I-TPSE--VFQDNCCKREISSLEVYCTN-SPLCTSVLALNQLQ---- C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004192 ----------XXXXX--------XXXXXXXXXXXXXX-------XXXX---XXXX---XXXXS----------I-VKDK--VFKDNCCKREILALQIYCRNESRGCAEQLTLGHLL---- C_familiaris_ENSCAFP00000031262 ----------------------------CAACLPENV-------RSGE------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003184 ---------------------------------------------SSS---PKCT---ACQES----------I-VKDK--VFKDNCCKREILALQICCRNESRGCAEQLALGHLL---- A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024090 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEAQVLSLPIRCIHSEEGCRWTGALRQLQ---- D_rerio_ENSDARP00000013849 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ---- H_sapiens_ENSP00000262395 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- G_aculeatus_ENSGACP00000014759 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEQQILALPIRCIHSEEGCRWTGQMKQLQ---- B_taurus_ENSBTAP00000050075 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ---- M_musculus_ENSMUSP00000017530 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ---- R_norvegicus_ENSRNOP00000018468 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQ---- G_gallus_ENSGALP00000012873 ----------AVQTP--------CGHRFCKGCIVKSIRRC----RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCCLKMELRHLE---- R_norvegicus_ENSRNOP00000006148 ----------AVQTP--------CGHRFCKACITKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCVQKMELRHLE---- O_latipes_ENSORLP00000005579 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEQQILSLPIRCIHSEEGCRWTGQMKQLQ---- D_rerio_ENSDARP00000014326 ----------PHQTG--------CGHIFCAQCVKAYT-------ENGG--SSKCP---LDSIP----------I-KPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ---- T_guttata_ENSTGUP00000010462 ----------AVQTP--------CGHRFCKGCIVKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNK--GCSMKMELRHLE---- T_rubripes_ENSTRUP00000012878 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEQQILALAIRCIHSEEGCRWTGQMKQLQ---- M_musculus_ENSMUSP00000004949 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLTVKCPNK--GCLQKMELRHLE---- A_carolinensis_ENSACAP00000005007 ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---IDNEI----------L-LETQ--LFPDNFAKREILSLTVKCPNK--GCDQKMELRHLE---- M_mulatta_ENSMMUP00000021907 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- O_anatinus_ENSOANP00000018657 ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVRCPNE--GCLMKMELRQLE---- P_pygmaeus_ENSPPYP00000003845 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- P_troglodytes_ENSPTRP00000006096 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- B_taurus_ENSBTAP00000021630 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- H_sapiens_ENSP00000316840 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- G_aculeatus_ENSGACP00000025883 ----------PQQNS--------CGHIFCFLCLRALR-------ESSPASGPVCP---VDGAA----------I-TPAG--VFQDNCCKREISGLEVYCVN-FPACASVVTLRRLQ---- M_domestica_ENSMODP00000024756 ----------AVQTP--------CGHRFCKACIVKSI-------RDAG---HKCP---VDNAI----------L-LETQ--LFPDNFAKREILSLTVKCPNE--GCLLKMELRHLE---- D_rerio_ENSDARP00000056877 ----------PVQVST-------CGHRFCDTCLQEYL-------SEGV---FTCP---EDQLP----------L-DYAK--IFPDLELEQQILSLPIRCIHSEEGCRWTAQNKLLQ---- C_familiaris_ENSCAFP00000010159 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- G_aculeatus_ENSGACP00000022648 ----------AIQTP--------CGHRFCKNCIEKSI-------RDTG---QRCP---VDNER----------L-LEDQ--LFPDNFAKREILSLTVRCPNS--DCADKMELRHLE---- T_rubripes_ENSTRUP00000041697 ----------AIQTP--------CGHRFCKICIEKSI-------RDAG---QRCP---VDNEM----------L-SKEQ--LFPDNFAKREILSLTVRCSNP--GCTGKMELRHLE---- X_tropicalis_ENSXETP00000042386 -----------------------RNHDLCPKCKAE----------------------------------------DPTT--LSDDSLLKEERFAF------------------------- T_nigroviridis_ENSTNIP00000012472 ----------AIQTP--------CGHRFCKNCIEKSI-------RDAG---QRCP---VDNEM----------L-SKEQ--LFPDNFAKREILSLIVRCSNP--GCTSKMELRHLE---- M_mulatta_ENSMMUP00000028200 --------------------------------------------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWNGPLRHLQ---- P_troglodytes_ENSPTRP00000015252 ------------------------------------L-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- D_rerio_ENSDARP00000036715 ----------AVQTP--------CGHRFCDSCIRKSI-------RDTG---QKCP---VDNEV----------L-LEEQ--LFPDNFAKREILSLTVKCSNF--GCSEKMELRQLE---- E_caballus_ENSECAP00000009502 --------------------------------------------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- P_pygmaeus_ENSPPYP00000009119 ---------------------------------------------EGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- X_tropicalis_ENSXETP00000016445 ----------AVQTP--------CGHRFCKACILKSI-------RDAG---HKCP---VDNES----------L-MENQ--LFPDNFAKREILSLRVKCPSQ--GCTETMELRHLE---- B_taurus_ENSBTAP00000016271 ------------------------------------------------------------------------------Q--IYPDPELEVQVLGLSIRCIHSEEGCRWNGPLRHLQ---- O_latipes_ENSORLP00000001290 ----------AIQTR--------CGHRFCKSCIEKSI-------RDTG---QRCP---VDNEM----------L-SEDQ--LFPDNFAKREILSLTVRCPNS--DCGEKMELRHLE---- G_gorilla_ENSGGOP00000016344 ----------PVXXPP-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---- X_tropicalis_ENSXETP00000056667 --------------------------------------------SEGV---FKCP---EDQLP----------L-DYAK--IYPDRDLETQVMGLSIRCIHSEEGCRWSGQLKQLQ---- E_caballus_ENSECAP00000018618 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---PD-EI----------L-YHP-----ASSLTRRESL-LCPMCPHC--MCYPPSKLYHRS---- T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000748 ----------PVKVST-------CGHRFCDTC-QSFL-------XXXX---XXXX---XXXXX----------X-XXXX--IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQ---- M_mulatta_ENSMMUP00000021905 ----------AVQTP--------CGHRFRKGCIIKSI-------RDAG---HKCP---VDDEI----------L-LENK--LFPDSFAKREILSLMVNCPNE--GCLHKMELRHLG---- C_intestinalis_ENSCINP00000003738 ----------PVALSN-------CEHHACSQCVSRLW-------KIS----RSCP---LDGKV----------I-DRNE--VTIDEKLQIELNNLNMVCPYKHCGCHWEGMFFDFK---- O_anatinus_ENSOANP00000028670 ---------------------------------------------------------------------------------FFSS----------------------------------- O_cuniculus_ENSOCUP00000010330 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLTVKCPNE--GCLHKMELRHLE---- C_elegans_F45G2.6 ----------PIKLN--------CDHHYCRQCFEN---------ENRT---PGCA---ACQTI----------I-QPEL--CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLH---- D_melanogaster_FBpp0111838 ASPV-PPPTPPRNKTTSGSGNCATSRSSSSTVSSSHS-------SSHS---SPTPGNNNNNMP----------I-TELEQIIYPGPDP-KHIMGSLVFCIHHKQGCKWSDELRKLK---- A_gambiae_AGAP010017-PA VLPITPPPAPPRNKST--S----TSSASTMSSSSSPS-------SSSS---SPTP---PPNVP----------I-TEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK---- O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006649-PA VLPITPPPAPPRNKSTTST----TSSASSSTSALSHS-------SATS---SPSP---PPNVP----------I-TEISQIIYPDPESEKAIMGSLVFCIHHKQGCKWSDELRKLK---- C_familiaris_ENSCAFP00000027741 ----------PVQVST-------CGHRFCDTCLQEFL-------SEGV---FKCP---EDQLP----------L-DYAK--IYPDPELEVQVLSLAIRCIHSEEGCRWSGPLRHLQ---- C_intestinalis_ENSCINP00000008928 ----------PVQITA-------CRHRYCDTCLQKFL-------GEGV---FNCP---VDHLS----------L-DYAK--IYPDPDLETEIMSLTTHCTNYSSGCKWTGKLHNLK---- G_gorilla_ENSGGOP00000012479 ----------PHQTG--------CGHRFCQHCILSLR-------ELNT--VPICP---VDKEV----------I-KSQE--VFKDNCCKREVLNLYVYCSN-APGCNAKVILGRYQ---- O_latipes_ENSORLP00000024257 ----------PRQTE--------CGHRFCYSCINDIL-------SCPN---PVCP---ADMEP----------L-FKDK--VGRKPADPSELMHLHPSATPPTCGSPTHLCHLCPQ---- G_gorilla_ENSGGOP00000005734 ----------AVQTP--------CGHRFCKACIIKSI-------RDAG---HKCP---VDNEI----------L-LENQ--LFPDNFAKREILSLMVKCPNE--GCLHKMELRHLE---- A_gambiae_AGAP003004-PA ----------PILTK--------CGHRFCRKCITDWL-------NEKN---SNCP---LDNEP----------LDIKCD--IFPDNCTRREISQIKKPCPNSMRGCGEQLSPTDID---- D_rerio_ENSDARP00000040549 ----------PHQTG--------CGHIFCAQCVKAYT-------ENGG--SSKCP---LDSIP----------I-KPEE--IFQDNCCKRELLNLEVFCTN-APECTQRFSLCNLQ---- D_melanogaster_FBpp0074051 ------------------------------MSLTKSS-------SRKD-------------------------LTEQNQYQNQNENQNQPKSTTIVKYEKSSCLFCNEWFDAQTFT---- A_aegypti_AAEL015342-PA -----------------------MLYSFRRNLLIQVP-------H------------------------------IHNLHLRTTDKITNPELTRLLTPC-----------SFPTFQ---- A_aegypti_AAEL011363-PA ----------------------MIFYSFRRNLLIQIP-------H------------------------------IHNLHLRTTDKITNPILTRLLTPC-----------SFSTFQ---- D_melanogaster_FBpp0071136 ----------PVLTS--------CGHRFCRSCLTAWM-------QKNN---QCCP---MDNKR----------LSAEHD--IFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELH---- 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 ----------------------------------------------SCH--E-GRCPLM-LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K P_troglodytes_ENSPTRP00000036949 ----------------------------------------------SCH--E-GRCPLM-LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K P_pygmaeus_ENSPPYP00000022191 ----------------------------------------------SCH--E-GRCPLM-LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K M_mulatta_ENSMMUP00000015132 VCGTVTEPAVGSRPRSPSGRDLVLHVLTGAEACLMSVEEETELLLRSCH--E-GRCPLM-LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADG-K E_caballus_ENSECAP00000011150 ----------------------------------------------SCH--E-GHCPFM-LTECPA-------CKGLVRLGE----KEH----HLEHECPERSLSCRHCRAPCCWADM-K C_familiaris_ENSCAFP00000028895 ----------------------------------------------SCH--E-GHCPFM-LTECPA-------CKGLVRLGE----KEH----HSEHECPERSLSCRHCRAPCCWADL-K M_musculus_ENSMUSP00000109872 ----------------------------------------------SCH--E-GLCPFL-LTECPA-------CKGLVRLSE----KEH----HTEQECPKRSLSCQHCRAPCSHVDL-E B_taurus_ENSBTAP00000013869 ----------------------------------------------SCH--E-GQCPFM-LTECPA-------CKGLVRLGE----KEH----HLEHQCPERSLSCRHCRAPCSPADM-K M_domestica_ENSMODP00000021625 ----------------------------------------------SCH--E-GHCSFM-LIECPA-------CKWMIKLGE----KEH----HSERECPKRSLNCRYCKALFYYPDI-K G_gallus_ENSGALP00000014649 ----------------------------------------------SCH--E-GNCPFL-LIECQA-------CRGVIPLNE----KER----HSERECPERTLNCKYCKSLFYFPDI-K R_norvegicus_ENSRNOP00000058607 ----------------------------------------------SCH--E-GLCPFL-LTECPA-------CKGLVRLSE----KKH----HTEQECPKRSLSCQHCRAPCSHADL-E G_gorilla_ENSGGOP00000006994 ----------------------------------------------SCH--E-GRCPLM-LTECPA-------CKGLVRLGE----KER----HLEHECPERSLSCRHCRAPCCGADV-K T_nigroviridis_ENSTNIP00000016461 ----------------------------------------------LSH--E-GKCEFM-IISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K T_guttata_ENSTGUP00000002510 ----------------------------------------------VQA--K-ARLGTS-ASFFPL-------C-----LGK----AQRVVCAHVGESCQIPGLYCQLEKFP-NVVHM-V G_aculeatus_ENSGACP00000006974 ----------------------------------------------ASH--E-DNCDFM-IIMCPS-------CKELMRANE----QER----HNERECPERTLNCRYCKEPFLLKNI-K O_latipes_ENSORLP00000003220 ----------------------------------------------LDH--E-GKCEFM-IIPCPS-------CKERIRFSE----QER----HSERECPERTLNCKYCKEPFHFKNI-K T_rubripes_ENSTRUP00000011363 ----------------------------------------------ARH--E-DSCDFM-IILCPS-------CKELMRVNE----QER----HNERECPERTLNCKYCKDPFQLKNI-K O_latipes_ENSORLP00000020860 ----------------------------------------------ASH--E-GSCDFT-IIMCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEPFLLKNI-K T_rubripes_ENSTRUP00000015632 ----------------------------------------------LNH--E-GKCEFM-IISCPS-------CKEHIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K T_nigroviridis_ENSTNIP00000013509 ----------------------------------------------ARH--E-DSCDFM-IILCPS-------CKELMRANE----QER----HNERECPERTLNCKYCKEAFQLKSI-K D_rerio_ENSDARP00000043465 ----------------------------------------------ANH--E-GKCDFR-ILPCPS-------CKELLRANE----LER----HNERECPERTLNCKYCKEPFHFKNI-K D_rerio_ENSDARP00000069217 ----------------------------------------------NQH--E-GRCAFE-RVKCEA-------CQVLILLSE----KDR----HNERECEARTLNCKYCKVTFNFKEI-K X_tropicalis_ENSXETP00000008559 ----------------------------------------------YCY--S-LGTCTA-LTHCVL-------CPGYPWNYS----GDL----HSERECPERKLNCRYCKLSFYFPDI-K G_aculeatus_ENSGACP00000020860 ----------------------------------------------LTH--E-GKCEFM-IIPCPS-------CKERIRFNE----QER----HNERECPERTLNCKYCKEPFHFKNI-K T_nigroviridis_ENSTNIP00000011878 ----------------------------------------------AQH--E-GRCEFE-QIKCDA-------CQAFVLRAE----KDR----HNERECEARTLNCKYCKFTFHFKDI-K T_rubripes_ENSTRUP00000047803 ----------------------------------------------AQH--E-GRCELE-QIKCDA-------CQASVLRAE----IDR----HNERECEARTLNCKYCKLTFHFKDI-K O_latipes_ENSORLP00000008989 ----------------------------------------------AKH--E-GRCEFE-QIQCEA-------CQALVLRKD----KDR----HNDRECEERTLNCKYCKVTFNFKDI-K G_aculeatus_ENSGACP00000022084 ----------------------------------------------AQH--E-GRCELE-RMQCEA-------CKMSVLCTD----KDR----HNERECEERTLNCKYCKMTFNFKEI-K A_carolinensis_ENSACAP00000006987 ----------------------------------------------SGH--G-GSCPWA-LATCPS-------CRGPVRRRD----QER----HAARECPQRSLSCKFCKALCHFPQI-K G_gallus_ENSGALP00000002401 -----------------------------------------------EH--Q-ILCEYA-LIPCHT------GCGHVVMRKK----LAD----HLENGCVNNVTVCHKCKQSLSSSEY-Q T_guttata_ENSTGUP00000006737 -----------------------------------------------EH--Q-SLCEYA-LIPCHT------GCGHVVMRRK----LAD----HLENGCVNNVTVCQQCQCSLATSEC-Q D_rerio_ENSDARP00000091948 ----------------------------------------------QDH--Q-SQCEYA-LIPCNI------GCGIMVQRKT----LAT----HLESGCPNNKTACPSCTSVLTPREL-Q O_anatinus_ENSOANP00000001757 ---------------------------------------------PQDH--Q-AECDCA-LIPCHA------GCGLMIMRKK----LPD----HLENGCAKSPTTCLKCKQTFCSMEY-- T_rubripes_ENSTRUP00000013348 -----------------------------------------------DH--L-NTCPFF-EVPCPLG-----KCKERMMRKE----IPE----HLSWKCKYRETSCEFCMTKMPLTEL-Q T_nigroviridis_ENSTNIP00000005138 -----------------------------------------------DH--L-NVCPFF-EVPCPLG-----KCKERMMRKE----IPD----HLSWKCKFRESSCEFCMTKMPLTEL-Q G_aculeatus_ENSGACP00000005703 -----------------------------------------------DH--L-NVCPFF-EVPCPLG-----KCKERMMRKE----IPD----HLSWKCKHRETSCEFCMTKMPLTDL-Q X_tropicalis_ENSXETP00000027864 -----------------------------------------------IH--LKSDCQFE-ELSCPRA-----DCKEKVIRKD----LSD----HIEKTCKYRETPCKFCRNQVPLVEM-Q E_caballus_ENSECAP00000011833 -----------------------------------------------VH--LKNDCQFE-ELACVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q D_rerio_ENSDARP00000038596 -----------------------------------------------EH--L-VICPYF-EVPCPLG-----KCKEKMMRKD----MPE----HLSRKCKHREVTCEFCSLKMALTEL-Q P_pygmaeus_ENSPPYP00000007003 -----------------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q P_troglodytes_ENSPTRP00000003288 -----------------------------------------------DH--L-QQCLFQ-AVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q C_familiaris_ENSCAFP00000026713 -----------------------------------------------VH--LKNDCQFE-ELSCVRA-----DCKEKVLRRD----LRD----HVEKACKYREATCPHCKSQVPMITL-Q A_carolinensis_ENSACAP00000000193 -----------------------------------------------TH--LRNDCLFE-ELPCPRV-----DCKEKILRKD----LPD----HAEKTCKYRETTCKYCKSQVPIIMI-Q P_troglodytes_ENSPTRP00000011503 -----------------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q M_mulatta_ENSMMUP00000038268 -----------------------------------------------DH--L-QQCLFQ-AVQCSNE-----NCQEPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q M_musculus_ENSMUSP00000021706 -----------------------------------------------VH--LKNECQFE-ELPCLRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIKL-Q P_pygmaeus_ENSPPYP00000000253 -----------------------------------------------DH--L-QQCLFQ-AVQCSNE-----KCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q R_norvegicus_ENSRNOP00000010906 -----------------------------------------------VH--LKNECQFE-ELPCLRA-----DCKEKVLRRD----LRD----HVEKACKYREATCAHCKSQVPMITL-Q G_gallus_ENSGALP00000036699 -----------------------------------------------MH--LKTDCQFE-ELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q O_anatinus_ENSOANP00000023053 -----------------------------------------------VH--LKSDCQFE-ELSCPRA-----DCKEKVLRKD----LPD----HIEKSCKYREATCKYCTSQVPMITL-Q H_sapiens_ENSP00000376500 -----------------------------------------------VH--LKNDCHFE-ELPCVRP-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q H_sapiens_ENSP00000336825 -----------------------------------------------DH--L-QQCLFQ-PVQCSNE-----KCREPVLRKD----LKE----HLSASCQFRKEKCLYCKKDVVVINL-Q T_guttata_ENSTGUP00000013203 -----------------------------------------------MH--LRTDCQFE-ELPCPRA-----DCKEKILRKD----LPD----HVEKTCKYRETTCKYCKSQVPMIML-Q B_taurus_ENSBTAP00000017918 -----------------------------------------------VH--LKNDCQFE-ELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMVTL-Q M_domestica_ENSMODP00000024498 -----------------------------------------------------------------------------------------------------------------------D O_anatinus_ENSOANP00000013484 -----------------------------------------------DH--L-QQCLFQ-PVQCSNE-----SCQEKVLRKD----MKD----HLGCHCKFREEKCQYCQKYVVAIDL-Q M_domestica_ENSMODP00000016701 -----------------------------------------------VH--LKSECQFE-ELPCVRA-----DCKEKILRKD----LQD----HVEKSCKYREATCQYCKSQVPMITL-Q E_caballus_ENSECAP00000005414 -----------------------------------------------DH--L-QQCLFQ-AVQCSNE-----HCQESVLRKN----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q T_guttata_ENSTGUP00000003276 -----------------------------------------------EH--L-QQCLFE-CTQCTND-----GCRDRVLRKD----LKE----HLRQQCKFREERCQYCNTYVVFINI-E G_gallus_ENSGALP00000016021 -----------------------------------------------EH--L-QQCLFE-SVQCTND-----GCCDQILRKD----LKD----HLSQHCKFREEMCQYCNKYVVLINI-K A_carolinensis_ENSACAP00000016112 -----------------------------------------------DH--L-QQCLFE-SVQCTNE-----GCCEKVLQKD----LKE----HLGLHCNYRKELCRYCNQPVTSINV-K B_taurus_ENSBTAP00000015940 -----------------------------------------------DH--L-QHCLFQ-PVQCSNE-----NCREPVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q P_troglodytes_ENSPTRP00000036416 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000362994 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000003305 -----------------------------------------------DH--L-LQCLFQ-SVQCSNE-----CCQERILRKD----LKN----HLELHCQFREEMCPFCNKDVVIIDL-Q M_musculus_ENSMUSP00000082710 -----------------------------------------------DH--L-QHCSFQ-AVPCPNE-----SCREAMLRKD----VKE----HLSAYCRFREEKCLYCKRDIVVTNL-Q M_mulatta_ENSMMUP00000026496 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000028234 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017853 -----------------------------------------------QYIWL-QYSTPR-AKVRVNRRSIGTSCKHTMCRGS----EGE----LLSHETALPGSSILLGKQEACILSLSQ O_cuniculus_ENSOCUP00000007884 -----------------------------------------------EH--L-QQCLFQ-VVQCSHD-----SCQEPVLRRD----LNE----HLSAYCQFREEKCLYCKKDVVVMDL-Q P_pygmaeus_ENSPPYP00000021917 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000009372 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015419 -----------------------------------------------VH--LKNDCHFE-ELPCVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMIAL-Q O_cuniculus_ENSOCUP00000004916 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000041215 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000002249 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000031605 -----------------------------------------------EH--L-GQCLYE-MTLCSND-----GCHDQMIRKE----LKG----HLESECKLRQEACIYCKQTMASINL-T C_intestinalis_ENSCINP00000001022 -----------------------------------------------------------------------------------------------------------------------S C_intestinalis_ENSCINP00000027890 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 -----------------------------------------------EH--L-KSCQYE-QLLCSNP-----GCTELLQRRL----LQE----HLNATCPHRRESCPHCLQPFQLSVI-Q C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004192 -----------------------------------------------XX--XXXXXXXX-XXXXXXX-----XXXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X C_familiaris_ENSCAFP00000031262 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003184 -----------------------------------------------VH--LKNDCQFE-ELACVRA-----DCKEKVLRKD----LRD----HVEKACKYREATCSHCKSQVPMITL-Q A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024090 -----------------------------------------------VH--L-SSCGYN-VVACPN------RCNGKLSRRD----LPS----HLQHECPKRRLKCDFCGIDFTGEAF-E D_rerio_ENSDARP00000013849 -----------------------------------------------SH--F-STCAFN-VIPCPN------RCSVKLTRRD----LPE----HLQHDCPKRKVKCEFCGSEFTGEAY-E H_sapiens_ENSP00000262395 -----------------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E G_aculeatus_ENSGACP00000014759 -----------------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E B_taurus_ENSBTAP00000050075 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E M_musculus_ENSMUSP00000017530 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E R_norvegicus_ENSRNOP00000018468 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E G_gallus_ENSGALP00000012873 -----------------------------------------------EH--Q-LHCDFT-TVECPQ-------CQGAFQKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E R_norvegicus_ENSRNOP00000006148 -----------------------------------------------DH--Q-VHCEFA-LVICPQ-------CQRFFQKCQ----INK----HIIEDCPRRQVSCVNCAVPMPYEEK-E O_latipes_ENSORLP00000005579 -----------------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAF-E D_rerio_ENSDARP00000014326 -----------------------------------------------DH--L-KACPHE-RVRCSHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMMQ T_guttata_ENSTGUP00000010462 -----------------------------------------------DH--Q-LQCDFS-TVECLQ-------CQGTFPKNH----LKE----HMTQECPRRQVCCPNCATSMAYEDK-E T_rubripes_ENSTRUP00000012878 -----------------------------------------------GH--F-STCAFN-VIPCPN------RCSVKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E M_musculus_ENSMUSP00000004949 -----------------------------------------------DH--Q-VHCEFA-LVNCPQ-------CQRPFQKCQ----VNT----HIIEDCPRRQVSCVNCAVSMAYEEK-E A_carolinensis_ENSACAP00000005007 -----------------------------------------------DH--Q-QHCGFA-SEKCPQ-------CQGIFQKNR----LQE----HIKLECPRRQVSCPNCALLMPYEDK-E M_mulatta_ENSMMUP00000021907 -----------------------------------------------DH--Q-AHCEFA-LVDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAALVAFEDK-E O_anatinus_ENSOANP00000018657 -----------------------------------------------EH--Q-SLCDYA-LVECPQ-------CHISFQKNI----LHD----HVVSECPRRQVSCVNCALSMAFEDK-E P_pygmaeus_ENSPPYP00000003845 -----------------------------------------------DH--Q-AHCEFA-LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E P_troglodytes_ENSPTRP00000006096 -----------------------------------------------DH--Q-AHCEFA-LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E B_taurus_ENSBTAP00000021630 -----------------------------------------------EH--Q-AHCEFA-LMSCPQ-------CQRPFQKCH----LNI----HILKECPRRQVPCENCAVSMAFEDK-E H_sapiens_ENSP00000316840 -----------------------------------------------DH--Q-AHCEFA-LMDCPQ-------CQRPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFEDK-E G_aculeatus_ENSGACP00000025883 -----------------------------------------------VE--P-THKQSD-NLVSPE------DVQRFLLKNQQLCPLQE----HLADTCPLRGEPRPHRQPPQRLTFI-Q M_domestica_ENSMODP00000024756 -----------------------------------------------DH--Q-THCEFA-LAECPQ-------CHLPFRKYL----LHN----HMVVECPRRQVSCVNCAAPMPFEEK-E D_rerio_ENSDARP00000056877 -----------------------------------------------AH--L-SVCEFN-VVSCPN------RCSVKLLRRE----LPE----HLQHDCAKRKLHCDHCGEQFTGEAY-E C_familiaris_ENSCAFP00000010159 -----------------------------------------------DH--Q-LHCEFA-LMNCLQ-------CQRTFQKCQ----LNI----HILKECPRRQVSCMNCAALMAFEDK-E G_aculeatus_ENSGACP00000022648 -----------------------------------------------NH--L-GRCQFA-TVPCSQ-------CQQAVRKSR----LEE----HQTAECQKRPVSCPDCVASFFYEER-K T_rubripes_ENSTRUP00000041697 -----------------------------------------------DH--L-AHCQFA-TVPCPH-------CQQSVRKTI----LEE----HMTAECRRRPVSCPDCIETFVYEER-E X_tropicalis_ENSXETP00000042386 -----------------------------------------------------NYTNAQ-LIVCP------------------------------------------------------- T_nigroviridis_ENSTNIP00000012472 -----------------------------------------------NH--L-ASCEFA-TVPCPH-------CQQSVKKTL----LEE----HTSVQCRRRPVSCPDCVEIFVYEEK-E M_mulatta_ENSMMUP00000028200 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E P_troglodytes_ENSPTRP00000015252 -----------------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E D_rerio_ENSDARP00000036715 -----------------------------------------------KH--L-SQCRFA-TAPCPQ-------CQESVPISH----LDE----HKSQHCLQRIMTCPDCAGSFVYAVK-Q E_caballus_ENSECAP00000009502 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E P_pygmaeus_ENSPPYP00000009119 -----------------------------------------------GH--L-NTCSFN-VIPCPN------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E X_tropicalis_ENSXETP00000016445 -----------------------------------------------RH--L-VRCDFA-GVECSQ-------CQSSFPKYS----LQK----HMFEECPRRQIFCENCALAMALEDK-L B_taurus_ENSBTAP00000016271 -----------------------------------------------GH--L-NTCSFN-VVPCPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E O_latipes_ENSORLP00000001290 -----------------------------------------------KH--L-AQCQFA-TVPCSQ-------CQQPVRKSY----LEE----HATVECPRRPMSCPDCVAVFVYEER-E G_gorilla_ENSGGOP00000016344 -----------------------------------------------XX--X-XXXXXX-XXXXXX------RCPMKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E X_tropicalis_ENSXETP00000056667 -----------------------------------------------PH--L-NICAFN-VIPCPN------RCSTKLIRRD----LPE----HMQHDCPKRKVRCEFCGADFTGEAY-E E_caballus_ENSECAP00000018618 -----------------------------------------------DH--Q-AHCEFA-LMNCPQ-------CQHPFQKCQ----LNI----HMLKECPRRQVSCVNCAVSMAFEDK-E T_nigroviridis_ENSTNIP00000019321 ---------------------------------------------------------------------------VKLTRRD----LPD----HLQHDCPKRKVKCEFCGSEFTGEAY-E O_cuniculus_ENSOCUP00000000748 -----------------------------------------------GH--L-NTCSFN-VVACPN------RCPAKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAY-E M_mulatta_ENSMMUP00000021905 -----------------------------------------------DH--Q-AHCEFA-LMDCPQ-------CQHPFQKFH----INI----HILKDCPRRQVSCDNCAASMAFIKR-S C_intestinalis_ENSCINP00000003738 -----------------------------------------------SH--Y-DECLYT-EEVCSN------DCGFRCSKHL----MDN----HLQIECSKRLVVCEFCALHLKAENE-I O_anatinus_ENSOANP00000028670 -----------------------------------------------------------------------------------------------------------------------Q O_cuniculus_ENSOCUP00000010330 ---------------------------------------------XXXX--X-XXXXXX-XXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X C_elegans_F45G2.6 -----------------------------------------------DH--L-SECTFKSSLKCEK-------CGRQFAKND----LEK----H-RAKCELNRAVCSFCNKTIRDSDR-E D_melanogaster_FBpp0111838 -----------------------------------------------GH--L-NACKHD-ATQCPN------KCGAQIPRIM----MTD----HLQYTCTMRRTRCEFCQSEFSGAGL-E A_gambiae_AGAP010017-PA -----------------------------------------------AH--L-NTCKHD-AIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006649-PA -----------------------------------------------AH--L-NTCKHD-AIQCPN------KCGSQIPRVM----MTD----HLAFTCILRRAICEFCNVEFTGIGL-E C_familiaris_ENSCAFP00000027741 -----------------------------------------------SH--L-NTCSFN-VIPCPN------RCPTKLSRRD----LPA----HLQHDCPKRRLKCEFCGCDFSGEAF-E C_intestinalis_ENSCINP00000008928 -----------------------------------------------AH--M-DKCSHS-ERDCPN------RCGVRIRSMK----LAD----HLEYECMKRRVACDFCGKEFTGEMM-D G_gorilla_ENSGGOP00000012479 -----------------------------------------------DH--L-QQCLFQ-AVQCSNE-----KCREAVLRKD----LKE----HLSAYCQFREEKCLYCKKDVVVINL-Q O_latipes_ENSORLP00000024257 -----------------------------------------------DH--V-NVCPFF-EVPCPLG-----KCKERMMRKE----IPE----HLAWKCKYRESTCEFCKNKMPLTEL-Q G_gorilla_ENSGGOP00000005734 -----------------------------------------------XX--X-XXXXXX-XXXXXX-------XXXXXXXXX----XXX----XXXXXXXXXXXXXXXXXXXXXXXXX-X A_gambiae_AGAP003004-PA -----------------------------------------------TH--L-RQCPFA-MSRQ-------------------------------------------------------- D_rerio_ENSDARP00000040549 -----------------------------------------------DH--L-KACPHE-RVRCSHS-----DCSDIVLRKN----LLE----HQRNACSYRLETCHYCRQNFPVSQMM- D_melanogaster_FBpp0074051 -----------------------------------------------EH--L-IHCGQV-LEECPN------GCQAFIPRIR----MRS----HLK-ECPRNQHNLSNQQRMSVSMDRLD A_aegypti_AAEL015342-PA -----------------------------------------------SH--I-ADCGQV-LSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAP------------- A_aegypti_AAEL011363-PA -----------------------------------------------SH--I-ADCGQV-LSKCPN------GCGVYVALKD----MDR----HLN-RCPAGFGEAP------------- D_melanogaster_FBpp0071136 -----------------------------------------------RH--L-PSCPYR-RQQEPQ------------------------------------------------------ 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE P_troglodytes_ENSPTRP00000036949 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE P_pygmaeus_ENSPPYP00000022191 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RVPCRFHAIGCL---E--TVEGE M_mulatta_ENSMMUP00000015132 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDHVK-TCGKC--RIPCRFHAIGCL---E--TVEGE E_caballus_ENSECAP00000011150 --AHH-----------------------------------------------------D-VCPKFPLTCDGCGK--KKISREKFQDHVR-TCGKC--RVPCRFHAVGCP---E--MVESE C_familiaris_ENSCAFP00000028895 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKISREKFQDHVR-ACGKC--RVPCRFHVVGCP---E--MVESE M_musculus_ENSMUSP00000109872 --VHY-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPRETFQDHVR-ACSKC--RVLCRFHTVGCS---E--MVETE B_taurus_ENSBTAP00000013869 --AHH-----------------------------------------------------Q-ICPKFPLTCDGCGK--KKIAREKFQDHVR-ACGRC--RVPCRFHAVGCP---E--MVESE M_domestica_ENSMODP00000021625 --AHD-----------------------------------------------------E-ICPKFPLTCEGCGK--KKILREKFQDHVK-ACGKC--KGPCKFHVVGCT---E--MVENE G_gallus_ENSGALP00000014649 --AHD-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDHVK-NCGKC--KVPCRFKVVGCA---E--MVENE R_norvegicus_ENSRNOP00000058607 --LHY-----------------------------------------------------E-VCPKFPLTCDGCG---KKISQEKLQDHVR-TCSKC--RVLCRFHAIGCS---E--LVETE G_gorilla_ENSGGOP00000006994 --AHH-----------------------------------------------------E-VCPKFPLTCDGCGK--KKIPREKFQDXVK-TCGKC--RVPCRFHAVGCL---E--TVEGE T_nigroviridis_ENSTNIP00000016461 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE T_guttata_ENSTGUP00000002510 --LHC-----------------------------------------------------E-ETPHCECSWRNCEGIWKKHPGAAFRDHVK-TCGRS--KVPCRFEAVGCA---E--VVENE G_aculeatus_ENSGACP00000006974 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKC--KAPCRFHVVGCDASVM--EVENE O_latipes_ENSORLP00000003220 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE T_rubripes_ENSTRUP00000011363 --AHD-----------------------------------------------------E-ICPKYPMICEGCSK--KKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---T--SVEKE O_latipes_ENSORLP00000020860 --AHD-----------------------------------------------------E-ICPKYPMMCEGCAK--KKIPREKYVDHIK-FCSKF--KAPCRFHVVGCD---T--SVEKE T_rubripes_ENSTRUP00000015632 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE T_nigroviridis_ENSTNIP00000013509 --AHD-----------------------------------------------------E-ICPKYPMMCEGCSR--RKIPREKYVDHIK-YCSKF--KSPCRFHVVGCN---I--KVEKE D_rerio_ENSDARP00000043465 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-LCTKF--RTPCRFHVVGCD---M--TVEKE D_rerio_ENSDARP00000069217 --AHD-----------------------------------------------------E-ICQKFPMQCKDCGK--KKIPREKFQEHTK-SCAKS--KSACQFREIGCR---A--VVDNC X_tropicalis_ENSXETP00000008559 --AHD-----------------------------------------------------E-ICPKFPMTCEGCGR--KKIPREKFPDHVK-ICGRC--KVPCRYAAVGCT---E--MVEND G_aculeatus_ENSGACP00000020860 --AHD-----------------------------------------------------E-ICPKYPMICEGCAK--KKIPREKYVDHIK-FCSKF--RTPCRFHVVGCD---M--SVEKE T_nigroviridis_ENSTNIP00000011878 --AHD-----------------------------------------------------E-ICSKFPLQCKDCGK--KKIPREKFNEHIK-SCAKS--KSACPFSEVGCK---S--VVENG T_rubripes_ENSTRUP00000047803 --AHD-----------------------------------------------------D-ICLKFPLPCKDCGK--KKIPREKFNEHIR-SCAKS--KSACPFSEVGCK---S--VVDNG O_latipes_ENSORLP00000008989 --AHD-----------------------------------------------------E-ICQKFPLQCKDCGK--KKIPREKFNDHAK-SCAKS--KSACPFSEVGCK---S--VVENG G_aculeatus_ENSGACP00000022084 --AHD-----------------------------------------------------E-ICLKFPLQCKDCGK--KKIPREKFNDHSK-SCAKS--KSSCPFNDVGCK---Y--MMENG A_carolinensis_ENSACAP00000006987 --AHD-----------------------------------------------------E-VCPKFPLTCEGCGK--RKIPREKFPEHVK-SCSKC--KAPCRFQPIGCN---V--VVSPS G_gallus_ENSGALP00000002401 --PH---------------------------------------------------------CPRKPKVCRSEPAVILMTGTFMLSDHLR-ASSVS--MDGCRFSEVGCS---F--GGSKE T_guttata_ENSTGUP00000006737 --VRT-----------------------------------------------------------FLSQIKAFQLVLIISSTFFFSSHS--TSSSN--KDGCCFSEVGCA---F--RGSKE D_rerio_ENSDARP00000091948 --V---------------------------------------------------------LLKKEKHVCPSSGDKKTAKTDKKQKNNQP-ANSKK--KEPCIFSDVGCP---F--KGNPD O_anatinus_ENSOANP00000001757 ----------------------------------------------------------------------------------QFNSPGS-TASRI--QDGCPFSVIGCS---FM-HGSRE T_rubripes_ENSTRUP00000013348 --KHK-----------------------------------------------------ETVCPAFPVSCPNHCSL-SSLPRSELSSHQH-ECPKA--QVSCPFHGYGCT---F--KGLNQ T_nigroviridis_ENSTNIP00000005138 --KHK-----------------------------------------------------ETVCPAFPVSCPNHCSF-SSLPRSELSNHQH-ECPKA--QVSCQFHGYGCT---F--KGLNQ G_aculeatus_ENSGACP00000005703 --KHK-----------------------------------------------------ETVCPAFPVSCPNHCSV-SSLPRSELSSHQN-DCPKA--QVCCQFQRYGCT---F--QGLNQ X_tropicalis_ENSXETP00000027864 --KHE-----------------------------------------------------DVDCPSVVISCPHMCSV-KSLLRSELNAHLL-ECVNA--PSTCSFKRYGCT---F--KGTNQ E_caballus_ENSECAP00000011833 --KHE-----------------------------------------------------DTECPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCI---F--QGTNQ D_rerio_ENSDARP00000038596 --KHK-----------------------------------------------------ETVCPAFPVACPNHCSF-SSILRSELSSHQH-DCPKA--QVTCSFIRYGCS---Y--KGLNQ P_pygmaeus_ENSPPYP00000007003 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ P_troglodytes_ENSPTRP00000003288 --NHE-----------------------------------------------------ENLCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR C_familiaris_ENSCAFP00000026713 --KHE-----------------------------------------------------DTECPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ A_carolinensis_ENSACAP00000000193 --KHE-----------------------------------------------------DADCPCVMVTCPHKCSV-SALLRKELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ P_troglodytes_ENSPTRP00000011503 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ M_mulatta_ENSMMUP00000038268 --NHE-----------------------------------------------------ENLCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR M_musculus_ENSMUSP00000021706 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ P_pygmaeus_ENSPPYP00000000253 --NHE-----------------------------------------------------ENLCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR R_norvegicus_ENSRNOP00000010906 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ G_gallus_ENSGALP00000036699 --KHE-----------------------------------------------------DTDCPCVMVSCPHKCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ O_anatinus_ENSOANP00000023053 --KHE-----------------------------------------------------DTECPCVVVSCPHKCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ H_sapiens_ENSP00000376500 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ H_sapiens_ENSP00000336825 --NHE-----------------------------------------------------ENLCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TDKRR T_guttata_ENSTGUP00000013203 --KHE-----------------------------------------------------DTECPCVMVSCPHKCSV-KTLMRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ B_taurus_ENSBTAP00000017918 --KHE-----------------------------------------------------DTECPCVAVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ M_domestica_ENSMODP00000024498 ----------------------------------------------------------------------------GTLFFWGFFQNSL-VPAED--QDRCPFADIGCS---F--KGGQE O_anatinus_ENSOANP00000013484 --NHE-----------------------------------------------------ENFCPDYPVSCPFSCC--QIIPRTEVDEHIS-VCPEA--EQDCPYKQYGCL---I--KDKRR M_domestica_ENSMODP00000016701 --KHE-----------------------------------------------------DTECPCVVVSCPHKCSV-QTLLRSELNAHLS-ECINA--PSTCSFKRYGCT---F--QGTNQ E_caballus_ENSECAP00000005414 --NHE-----------------------------------------------------ENMCPEYPVSCPNKCL--QIIPRTEVDEHLA-VCPEA--EQDCPFKQYGCP---V--KDKRG T_guttata_ENSTGUP00000003276 --NHE-----------------------------------------------------KNDCPDYPVPCLQNCS--QIILKKEIEKHHA-VCPEA--EVDCPYKQYGCH---V--KVKRG G_gallus_ENSGALP00000016021 --NHE-----------------------------------------------------ENDCPDYPMPCLQNCS--QIILKKEIEKHHT-VCPET--EVDCPYKQYGCL---I--KVKRG A_carolinensis_ENSACAP00000016112 --THE-----------------------------------------------------RRDCPEYPLICPHGCT--QTILMKEAEEHIL-VCPAV--EIDCPYKQYGCP---A--KIKRG B_taurus_ENSBTAP00000015940 --NHE-----------------------------------------------------ENLCPDYPVSCPNKCL--QTIPRTEVDEHLA-VCPEA--EQDCAFKNYGCA---V--KDKRG P_troglodytes_ENSPTRP00000036416 ----------------------------------------------------------DQICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ H_sapiens_ENSP00000362994 ----------------------------------------------------------DQICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GIGCPFAGVGCS---F--KGSPQ M_domestica_ENSMODP00000003305 --NHK-----------------------------------------------------EQFCPNYPVSCPNNCL--QIITRTKVNEHIS-VCPEV--EQECAYKHYGCP---V--KDKRS M_musculus_ENSMUSP00000082710 --DHE-----------------------------------------------------ENSCPAYPVSCPNRCV--QTIPRARVNEHLT-VCPEA--EQDCPFKHYGCT---V--KGKRG M_mulatta_ENSMMUP00000026496 ----------------------------------------------------------DQICPKCRGEDLQSVSP-GSRLRTLERAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ M_musculus_ENSMUSP00000028234 ----------------------------------------------------------DRICPKCRADNLHPVSP-GS-PLTQEKVHSD--VAEA--EIMCPFAGVGCS---F--KGSPQ C_familiaris_ENSCAFP00000017853 --NHE-----------------------------------------------------ENLCPEYPVPCPNKCS--QIIPRTEVDEHLT-VCPEA--EQDCPFKHYGCT---V--KDKRG O_cuniculus_ENSOCUP00000007884 --NHE-----------------------------------------------------ENLCPEYPVSCPNKCL--QIIPRTEVNRHLA-VCPEA--EQDCPFKQYGCT---V--KEKRG P_pygmaeus_ENSPPYP00000021917 ----------------------------------------------------------DQICSKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KGSPQ E_caballus_ENSECAP00000009372 ----------------------------------------------------------DRVCLKCRGDDSQSVGP-GS-LVSQEKVHSD-AVAEA--GVGCPFAGVGCS---F--KGSPK M_mulatta_ENSMMUP00000015419 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ O_cuniculus_ENSOCUP00000004916 ----------------------------------------------------------DRICPACKGDNPTSVSP-GS-LRTQEKXXXX--XXXX--XXXXXXXXXXXX---X--XGNAQ B_taurus_ENSBTAP00000041215 ----------------------------------------------------------DRICPKCKGDDTPSESP-GS-LLSQEKDHPE--VAEA--GVGCPFAGVGCS---F--KGSPK G_gorilla_ENSGGOP00000002249 ----------------------------------------------------------DQICPKCRGEDLQSISP-GSRLRTQEKAHPE--VAEA--GVGCPFAGVGCS---F--KXXXX X_tropicalis_ENSXETP00000031605 --IHV-----------------------------------------------------GLYCQLYPVPCPNACP--VTCPRAELDKHLC-ECPEA--ELQCTFSNYGCN---V--MVKRG C_intestinalis_ENSCINP00000001022 --RHQ-----------------------------------------------------SGENSSFASSQPES-------VDQIPQNHLN-ESPYV--LNNEALSLESSL---T--TGDLN C_intestinalis_ENSCINP00000027890 ----L-----------------------------------------------------STENVS-PSLQRSS-------V---FNSWTS-KSPID--FSISEPSFNFNG---L--SHPEV C_intestinalis_ENSCINP00000001432 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 --DHV-----------------------------------------------------QSSCPKVKGGCPDGCS--TLVPKNRLTEHGE-SCPEV--HTDCSFKMFGCS---V--KGKRR C_intestinalis_ENSCINP00000005981 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004192 --KHE-----------------------------------------------------DTDCPCVVVSCPHKCSV-QTLLRSELSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ C_familiaris_ENSCAFP00000031262 ----------------------------------------------------------DRICPKCQGDDPQSGSP-GS-PLSQEKDPPE--VAEA--EVGCPFAGVGCP---Y--KGSPR O_cuniculus_ENSOCUP00000003184 --XXX-----------------------------------------------------XXXXXXXXXXXXXXXXX-XXXXXXXLSAHLS-ECVNA--PSTCSFKRYGCV---F--QGTNQ A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024090 --SHEGVCPQESVYCENKCGARMMRRLLGQHMMAECPKRTQPCAYCTKEFVYDTIQNHQHQCPRYPIPCPNQCGM-GSIPREDLNSHLKENCSTV--PVLCPFKDAGCK---H--RCPKL D_rerio_ENSDARP00000013849 --NHQGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQNHQYHCPRFPVQCPNQCGT-PNIAREDLANHVKESCGSA--LVLCPFKEAGCK---H--RCPKM H_sapiens_ENSP00000262395 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL G_aculeatus_ENSGACP00000014759 --NHQGVCPQESVYCENKCGARMMRRLLSQHGLAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL B_taurus_ENSBTAP00000050075 --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL M_musculus_ENSMUSP00000017530 --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H--RCPKL R_norvegicus_ENSRNOP00000018468 --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPTHLKDSCSTA--FVLCPFKESGCK---H--RCPKL G_gallus_ENSGALP00000012873 --LHD------------------------------------------------------QTCPLANVFCEYCN---TMLIRQQMPNHYDNDCPTA--PVPCFYSAFGCP---E--KMQRN R_norvegicus_ENSRNOP00000006148 --IHD------------------------------------------------------QSCPLANIICEYCG---TILIREQMPNHYDLDCPTA--PVPCTFSVFGCH---E--KMQRN O_latipes_ENSORLP00000005579 --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQFHCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL D_rerio_ENSDARP00000014326 --GHQ-----------------------------------------------------KSSCPDVEVPCSNNCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V--RDKRG T_guttata_ENSTGUP00000010462 --LHD------------------------------------------------------QTCPLANIYCEYCN---TVLIREQMPNHYDNDCPTA--PVPCFYSAFGCP---E--KMQRN T_rubripes_ENSTRUP00000012878 --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCSKEFVFDTIQNHQYHCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL M_musculus_ENSMUSP00000004949 --IHD------------------------------------------------------QSCPLANIICEYCG---TILIREQMPNHYDLDCPTA--PIPCTFSVFGCH---E--KMQRN A_carolinensis_ENSACAP00000005007 --VHD------------------------------------------------------GVCLLANVCCEYCN---TVLIREQLPNHYDNDCPTA--PVPCTYSDFGCP---E--KMQRN M_mulatta_ENSMMUP00000021907 --IHD------------------------------------------------------QNCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN O_anatinus_ENSOANP00000018657 --YHD------------------------------------------------------QNCPLASVFCEYCS---TVLIREQMPTHYDMDCPTA--PIPCTFSSFGCR---E--KMQRN P_pygmaeus_ENSPPYP00000003845 --IHD------------------------------------------------------QNCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN P_troglodytes_ENSPTRP00000006096 --IHD------------------------------------------------------QNCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN B_taurus_ENSBTAP00000021630 --IHE------------------------------------------------------QNCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PVPCTFSAFGCH---E--KMQRN H_sapiens_ENSP00000316840 --IHD------------------------------------------------------QNCPLANVICEYCN---TILIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN G_aculeatus_ENSGACP00000025883 --DRV-----------------------------------------------------QSSC--LQVDCPESCS--PKAPRHKLE-----SCPEQVEQVDCSYKKFGCS---V--QDTRG M_domestica_ENSMODP00000024756 AKFHD------------------------------------------------------QNCPLATVFCEYCS---TMLIREQMPNHYDIDCPVA--PIPCTFSTFGCR---E--KMPRN D_rerio_ENSDARP00000056877 --NHQGVCPEESVYCENKCGARMVRRLLAQHSVSECLKRKLPCRYCKKEFLYDTIQNHQQQCPRFPMQCPNRCGT-PGITRDTLMAHVKEGCSTA--MVLCPFKEAGCK---H--RSPKT C_familiaris_ENSCAFP00000010159 --IHD------------------------------------------------------QNCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---V--KMQRN G_aculeatus_ENSGACP00000022648 --LHQ------------------------------------------------------QRCPFAIVKCLFCD---LELIRDQIESHCDTDCPKA--PIACNFSAFGCK---E--SMQRH T_rubripes_ENSTRUP00000041697 --RHE------------------------------------------------------QQCPFASVMCPYCD---MDLVRDQMESHCDTDCPIA--PIACTFSLFGCK---E--RMQRH X_tropicalis_ENSXETP00000042386 --EHS-----------------------------------------------------------------------------------------------------------F--SGSRE T_nigroviridis_ENSTNIP00000012472 --RHE------------------------------------------------------QQCPFASVMCPHCD---MDLTRDQMESHCDTDCPKA--PIACNFSLFGCK---E--RMQRH M_mulatta_ENSMMUP00000028200 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL P_troglodytes_ENSPTRP00000015252 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL D_rerio_ENSDARP00000036715 --NHE------------------------------------------------------QFCPFANTVCEYCE---MELIRDQLALHCDTDCLKA--PVACTFSTFGCR---E--KMTRN E_caballus_ENSECAP00000009502 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCAKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL P_pygmaeus_ENSPPYP00000009119 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCSKEFVFDTIQSHQYQCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL X_tropicalis_ENSXETP00000016445 --NHD------------------------------------------------------QTCPLAYVTCEYCQ---TNLIREQMPAHYSMDCTMA--PIPCMYYEFGCT---E--KMQRN B_taurus_ENSBTAP00000016271 --SHEGVCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL O_latipes_ENSORLP00000001290 --MHE------------------------------------------------------QQCPFASVMCQYCE---MDLIRDQMESHCDTDCPKA--PIACTFSIFGCK---E--RMQRH G_gorilla_ENSGGOP00000016344 --SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGV-GTVAREDLPGHLKDSCNTA--LVLCPFKDSGCK---H--RCPKL X_tropicalis_ENSXETP00000056667 --DHQGCCPQESVYCENKCGARMMRRVLSQHSLVECPKRTQPCPYCNKEFVFDTIQSHQYQCPRYPTPCPNQCGI-ASIAREDLSNHLKDSCSSA--LVLCPFKDSGCK---H--RGPKI E_caballus_ENSECAP00000018618 ASIHD------------------------------------------------------QNCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFNTFGCH---E--KMQRN T_nigroviridis_ENSTNIP00000019321 --NHQGVCPQESVYCENKCGARMMRRLLSQHGMAECPKRTQPCKYCGKEFVFDTIQNHQYHCPRFPVQCPNQCGT-PNIAREDLANHVKDNCGSA--LVLCPFKDAGCK---H--RCPKL O_cuniculus_ENSOCUP00000000748 --SHEGMCPQESVYCENKCGSRMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKDSCSTA--LVLCPFKDSGCK---H--RCPKL M_mulatta_ENSMMUP00000021905 --V-D------------------------------------------------------QNCPLANVICEYCN---TILIREQ-ASYYDVDCPTA--PIPCTFRTFDCH---E--KMQRN C_intestinalis_ENSCINP00000003738 --EHL------------------------------------------------------KSCIRFPVTCPKKCGT-KEIPREELNAHLELDCQLA--DKVCPYETVGCT---F--TCSRE O_anatinus_ENSOANP00000028670 --AHD------------------------------------------------------EICPKFPLTCEGCGK--KKIPREKFQDHVK-TCGKC--RTPCRFQVVGCP---EMPGRRVH O_cuniculus_ENSOCUP00000010330 --IHD------------------------------------------------------QNCPLANVICEYCN---TMLIREQMPNHYDLDCPTA--PIPCTFSTFGCH---E--KMQRN C_elegans_F45G2.6 --RHP------------------------------------------------------KTCPQVIISCPFQCGL-TDRPRLEIEAHCP-SCPNV--DNVCPFVPYGCT---F--AGGKE D_melanogaster_FBpp0111838 --EHNGSCGQEPVYCEAKCGQRILRGRMTLHKSKDCAKRLRRCAHCQREFSADTLPLHAAQCPRAPLACPQRCDA-GPIPRGELEAHLRDECQSL--AVSCSFKEAGCR---F--KGPRQ A_gambiae_AGAP010017-PA --EHAGTCSSEPIYCESKCGTRVLRGRMSIHRAKDCAKRLRRCPHCGREFCADTLAAHGATCPRSPIPCPQRCDA-GPFARADLDAHLRDECKAL--TVPCTFKEAGCR---F--KGPRH O_anatinus_ENSOANP00000019424 -----------------------------------------PCPYCTKEFVFDTIQNHQYQCPRFPLPCPNQCGT-GAVAREDLPGHLKENCNTA--PVLCPFKDAGCK---H--RCPKL A_aegypti_AAEL006649-PA --EHAGTCSSEPIYCESKCGTRVVRGRMSIHRAKDCAKRLRRCPHCSREFSADTLSAHGATCPRSPVPCPQRCDA-GPFARADLEGHLRDECKAL--SVPCTFKEAGCR---F--KGPRH C_familiaris_ENSCAFP00000027741 --SHEGVCPQESVYCENKCGARMMRRLLAQHAASECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVPCPNQCGV-GTVAREDLPGHLKESCSTA--LVLCPFKDSGCN---T--GCPAF C_intestinalis_ENSCINP00000008928 --EHEGACPQESVHCENKCGAKMLRKYLSRHVTGDCPKRPTKCTHCSKDFNIDILQTHHGTCPRYPIGCPNRCDV-LKIPREELEIHLKEHCKSA--LTACPFKEAGCK---H--KCPRY G_gorilla_ENSGGOP00000012479 --NHE-----------------------------------------------------ENLCPEYPVFCPNNCA--KIILKTEVDEHLA-VCPEA--EQDCPFKHYGCA---V--TXXXX O_latipes_ENSORLP00000024257 --KHK-----------------------------------------------------ETVCPAFPVSCPNHCTS-SSLPRSELSSHQH-DCPKA--QVSCQFHRYGCS---F--KGLNL G_gorilla_ENSGGOP00000005734 --XXX------------------------------------------------------XXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXX---X--XMXRN A_gambiae_AGAP003004-PA -------------------------------------------------------------------------------------------------SQPCPFARVKCK---FV-APDEA D_rerio_ENSDARP00000040549 --GHQ-----------------------------------------------------KSSCPDVEVPCSNNCT--QMIKRHQLQAHAD-ECLEV--ETDCVYKNYGCT---V--RDKRG D_melanogaster_FBpp0074051 --RQS-----------------------------------------------------DQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEK---AMDDLRRQ A_aegypti_AAEL015342-PA --HQD-----------------------------------------------------GDRIRELELEIVGLRSTLNEEIRQRLALITDIGQLKKRTQLGDEWTAKVGD---VLNALKKC A_aegypti_AAEL011363-PA --HQD-----------------------------------------------------GDRIRELELEIVGLRSTLNEEIRQRLALITDIGQLKKRTQLGDEWTAKVGD---VLNALKKC D_melanogaster_FBpp0071136 -------------------------------------------------------------------------------------------------EEKCPFAKIKCD---FVGRPETN 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 KQQEHEVQWL---REHLAMLL--SSVLEAKPLLGDQ------------------------------------------------------SHAGSELL-------------------QRC P_troglodytes_ENSPTRP00000036949 KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------------------------------------SHAGSELL-------------------QRC P_pygmaeus_ENSPPYP00000022191 KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------------------------------------SHAGSELL-------------------QRC M_mulatta_ENSMMUP00000015132 KQQEHEAQWL---REHLAMLL--SSVLEAKPLLGDQ------------------------------------------------------SHAGSELL-------------------QRC E_caballus_ENSECAP00000011150 KQQEHEAKWL---QEHLAMLLDSSSFLGQSQVGNPG----------------------------------------------------AEVSKAAELL-------------------QRC C_familiaris_ENSCAFP00000028895 KQQQHEAHWL---REHLAMLL--GSLLEAKHLSGAG-----------------------------------------------------GPFLGLKLQ-------------------QRC M_musculus_ENSMUSP00000109872 NLQDHELQRL---REHLALLL--SSFLEAQASPGTL------------------------------------------------------NQVGPELL-------------------QRC B_taurus_ENSBTAP00000013869 QQPEHEAQRL---QEHLALLL--GVLLEAGRPPGDS----------------------------------------------------RLLLRVAELL-------------------QRC M_domestica_ENSMODP00000021625 KQQDHENQKV---AEHLCMLL--NFVLEARHFHGDI-----------------------------------------------------EMSKSTELL-------------------ERC G_gallus_ENSGALP00000014649 KLPEHESKCL---AEHLYMLL--SFVLSLKSGSGDLKHLPAIPSSQSSSPLLAA----------------------------NSLCPESELFKSLELL-------------------GRC R_norvegicus_ENSRNOP00000058607 DLQDHELQRL---REHLALLL--SSFLESQASQNQV---------------------------------------------------------GPELL-------------------QRC G_gorilla_ENSGGOP00000006994 KQQEHEAQWL---REHLAMLL--SSVLEAKPLSGDQ------------------------------------------------------SHAGSELL-------------------QRC T_nigroviridis_ENSTNIP00000016461 KIHDHERAFA---YEHLNLLL--HYIMGMKASRAG------------------------------------------------------EKTKVAELG-------------------RRC T_guttata_ENSTGUP00000002510 KLPEHERKCL---AEHLYMLM--SSVLSLKTGAGDL--------------------------------------------------------KPLPLL-------------------GRC G_aculeatus_ENSGACP00000006974 KLHDHERQCS---YEHLNLLL--HFIMGIK------------------------------LQLQ------------------------SEKAKVAELS-------------------RRC O_latipes_ENSORLP00000003220 KIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLETAGHKLVELQKSL-RDLEARVS--QLSTTSSGP---------------PVQGAAAS-------------------SSS T_rubripes_ENSTRUP00000011363 KIHDHERQCS---YEHLNLLL--HFIMGIKISLESLPPQSLDVASHKLLELHQSL-RDLELKLQ------------------------SEKTKVAELS-------------------RRC O_latipes_ENSORLP00000020860 KIHDHERQCS---YEHLNLLL--HFIMGIKGVCAATLATS-------FTPLHSAMGAALELQLQ------------------------SEKTKVAELS-------------------RRC T_rubripes_ENSTRUP00000015632 KIHDHERAYA---YEHLNLLL--HYIMGMKVSMEGLQPQGLEVAGQKLVELQQSL-RELELSVS----TSFTPLPSSVG-AALELQLHSEKTKVAELG-------------------RRC T_nigroviridis_ENSTNIP00000013509 KIHEHERQCS---YEHLNLLL--HFIMGIKSS-------------------------------R------------------------AKKTKVAELS-------------------RRC D_rerio_ENSDARP00000043465 KIHDHEQACS---YEHLNLLL--HFIMGIKVNLESLQPQSLELASHKIHELHQSL-RELEL--------------------------------------------------------KMG D_rerio_ENSDARP00000069217 KQQEHEQTSI---MEHLRLML--ALLSSMRLR---AEGAG-EWQEDVGLGLYRGPEDA------------------------------PPAGAHNVGR-------------------GGG X_tropicalis_ENSXETP00000008559 KCLEHENKSL---AEHLAKGS--PAPPANAPP--------------------------------------------------------NNSAKVAEML-------------------LKF G_aculeatus_ENSGACP00000020860 KIHDHERAFA---YEHLNLLL--HYIMGMKVSMEGLQPQGLELAGHKLLELQQAL-RELEARVS--QLSTTSSGP---------------PVQ--------------------------C T_nigroviridis_ENSTNIP00000011878 KLSEHENSST---MEHMRLLL--PIVLSLTQARAEVSDSG-EWQEDSVLGLYRAPEEG------------------------------VHVGAGAAAS-------------------VH- T_rubripes_ENSTRUP00000047803 KLREHEHSST---VEHLHLLL--PMVLSLTRTRAEVSESG-EWQEDSGLGLYRAPEEG------------------------------VNVGAGAAAS-------------------VHA O_latipes_ENSORLP00000008989 KISEHEHSST---MEHLRLLL--PMVLSMTRTRLDTSPSG-EWQEDSGLGLYRAPDD----------------------------------GCGAAAS-------------------VPS G_aculeatus_ENSGACP00000022084 KLGDHEHSSA---VEHLRLLL--PLVLS-SVSLAGGDAAG-ELQEDSGLGLYRAPEEG------------------------------VATGAGAAAS-------------------ALS A_carolinensis_ENSACAP00000006987 RWDE-AGPII---YKYC------------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000002401 KIKEHEKAAV---GTHMLLLL--QYIKQLKANLCTVSKAA---------------------------------------------------NGFISQTELN------------------- T_guttata_ENSTGUP00000006737 KIQEHQNSAV---GAHMLLLL--QHMRQLQGTLCS--------------------------------------------------------KGFSPRPELN----------------KVI D_rerio_ENSDARP00000091948 KVKEHESCSH---AGHLQLLL--DVTRALQRTLNSATERVYQDS-------PVFLEPGPNGSSL----APQADGDIETD------GGDPGVELAAG---------------------QQL O_anatinus_ENSOANP00000001757 KVKEHETSSM---DMHLGLLL--QAVSQTKANQGDC-----------------------------------------------------EEELALQRFMRE----------------KLI T_rubripes_ENSTRUP00000013348 VMRQHESSSA---AEHLRMMA--KRNSALESKLDDVKGEL-----------------LERFKVL--PVLSSRVAELESS-NDELREKNRQTEQKLGTMQKL-----------MSSHSEKL T_nigroviridis_ENSTNIP00000005138 LMRQHESTSA---AEHLRMMA--KRNSMLEGKLDDVKGEL-----------------LERLKHL--PVVSSRVSELENA-SDELREKNRQMEQKLATMQKL-----------MSSHSEKL G_aculeatus_ENSGACP00000005703 DMRQHESTSA---GEHLRMIA--NKNSVLENKVEDIKGEL-----------------LERYKVL--PALSSRLSELENQ-SDELREKNRQVEQKLATMQKL-----------MSSHSEKL X_tropicalis_ENSXETP00000027864 QIKAHEASSA---VQHVNLMK--EWSNYLEAKVSMLQNES-----------------SEKNKSI--QILHNQMCSFEIE-IERHKEQLRNNEARIIQLQRV-----------IEGQADKL E_caballus_ENSECAP00000011833 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL D_rerio_ENSDARP00000038596 EMREHESSFA---SEHLRMMA--VRNTTLEAKVEDVKSEL-----------------MERYKVL--PSLSSRLAEVERQ-YEEMREKNRQLEQKLVSMQML-----------MSSHSEKL P_pygmaeus_ENSPPYP00000007003 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL P_troglodytes_ENSPTRP00000003288 NLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQKESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS C_familiaris_ENSCAFP00000026713 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL A_carolinensis_ENSACAP00000000193 QVKAHETSSA---VQHVDLLK--EWSNCLENKVAMLQNES-----------------LEKNKSI--QTLHNQICSFEIE-IERQKEMLRSNESKIHHLQRV-----------IDSQAEKL P_troglodytes_ENSPTRP00000011503 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL M_mulatta_ENSMMUP00000038268 NLQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQKESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS M_musculus_ENSMUSP00000021706 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL P_pygmaeus_ENSPPYP00000000253 NLQEHERSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQKESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS R_norvegicus_ENSRNOP00000010906 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL G_gallus_ENSGALP00000036699 QIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-----------------LEKNKSI--QTLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL O_anatinus_ENSOANP00000023053 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL H_sapiens_ENSP00000376500 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL H_sapiens_ENSP00000336825 NLQQHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQKESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS T_guttata_ENSTGUP00000013203 QIKAHEASSA---VQHVNLLK--EWSNALENKVALLQNES-----------------LEKNKSI--QTLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL B_taurus_ENSBTAP00000017918 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL M_domestica_ENSMODP00000024498 RVKEHEASSL---SDHLRRLL--ELVIRTKVQAGPSRGRGASGRRQAAEPEPKAPERNLSDLQL--QGAVEVNGDLEAD-YFHAASSDSEEELALQRFMKE----------------KLL O_anatinus_ENSOANP00000013484 NLREHENAAL---REHMLLVL--DKNSRLEEKISDLHRSL-----------------EVKELKI--QQLAEMVKKFEKE-FRQVMQLFSKNGNLLANTQIL------------ANHIDKS M_domestica_ENSMODP00000016701 QIKTHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL E_caballus_ENSECAP00000005414 NLQEHEHSAL---RDHMLLVL--EKNLQLEKQISDLHRSL-----------------ERKESKI--QQLTETVNKFEKE-FKQFAQLFGKNGSFLSNIQLL------------ASHLDKS T_guttata_ENSTGUP00000003276 KLAEHENSAL---REHMLQIL--DKNSRLEEQISDLYKNL-----------------EYKEIKI--QQLADAIKKCEKE-FRQYTQLFGNNSNLMVSTQAL------------ASHLDKS G_gallus_ENSGALP00000016021 KLAEHENGAL---REHMLQIL--DKNSRLEEQISDLYKSL-----------------ECKEIKI--QQLAEAVKKCEKE-FRQFTQLFGKNSNLMVSTQTL------------ASHLDKS A_carolinensis_ENSACAP00000016112 KVLEHENIYL---REHMLQIL--DRNSKLEDQISELYKNL-----------------EHKEIKI--QHLADMVKKCEKE-FRQFTQLYSKNNNLLASTQTL------------AIHIDKS B_taurus_ENSBTAP00000015940 NLQEHERSAL---RDHMLLVL--EKNFQLEEQISDLYKSL-----------------EQKESKI--QQLAEMVKKFEKE-FKQFAQLFGKNGSFLSNMQVL------------ASHIDKS P_troglodytes_ENSPTRP00000036416 SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL H_sapiens_ENSP00000362994 SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL M_domestica_ENSMODP00000003305 NLKKHENSAL---REHMLLVL--ERNSRLEEQIFDLHKNL-----------------ELKESKI--QQLSETVKKFEKE-FRQFVQLFGKNGNLLASTQVL------------ASHIDKS M_musculus_ENSMUSP00000082710 NLLEHERAAL---QDHMLLVL--EKNYQLEQRVSRIIEAL-----------------SRKQTHS--QRLPLTAPKKKKE-HPALRPICSVSGTLVSSGKAL------------TSHTDKS M_mulatta_ENSMMUP00000026496 SVQEHEVTSQ---TSHLNLLL--GFMKQWKTRLGSGLESG-----------PMALEQNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL M_musculus_ENSMUSP00000028234 SMQEHEATSQ---SSHLYLLL--AVLKEWKSSPGSNLGSA-----------PMALERNLSELQL--QAAVEATGDLEVD-CYRAPCCESQEELALQHLVKE----------------KLL C_familiaris_ENSCAFP00000017853 SLQEHEHSAL---RDHMLLVL--EKNLQLEEQISDLYKSL-----------------EQKESKI--QQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQVL------------ANHIDKS O_cuniculus_ENSOCUP00000007884 SLQEHEHSAL---REHMLLVL--EKNFRLEEQISDLCKSL-----------------EQKESKI--QQLAETVKKFEKE-FKQFAQLFGKNGSFLSNIQXX------------XXXXXXX P_pygmaeus_ENSPPYP00000021917 SVQEHEVTSQ---TSHLNLLL--GFMKQWKARLGCGLESG-----------PMALEQNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL E_caballus_ENSECAP00000009372 FMQEHEVASQ---ATHLNLVL--GFMKQWKAQLGSGLGSG-----------PMALEQNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHFMKE----------------KLL M_mulatta_ENSMMUP00000015419 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL O_cuniculus_ENSOCUP00000004916 SLQEHEATSQ---ASHLNLLL--GFMKQWKAQLGSGLGSG-----------PMALERNLSDLQL--QAAVEVAGDLEVD-CYRAPCSESQEELALQHLMKE----------------KLL B_taurus_ENSBTAP00000041215 FMEEHEVTSQ---AAHLNLLL--GFMKQWKAQLGSGLGYG-----------PMALERNLSDLQL--QGAVEVAGDLEVD-CYRAPCSESQDELALHHFMKE----------------KLL G_gorilla_ENSGGOP00000002249 XXXXXXXXXX---XXXXXXXX--XXXXXXXXXXXXXXXXX-----------XXXXXXXXXXXXX--XXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX----------------XXX X_tropicalis_ENSXETP00000031605 KVKEHEDTFL---RDHMLYVL--NRNMKLEEQVLGLQQNL-----------------DLKEHQI--QQLSDTVKWCEKE-CHQFGQFTGSNGNSLSSTKTL------------ASYIDKS C_intestinalis_ENSCINP00000001022 SVKAQCEYSH---KILQRQLQ--EMKNAVE-----LEMRK-----------------RESDRDG--NVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDAANKRANTDLTQKV C_intestinalis_ENSCINP00000027890 GISDYCKSEH---DALRSHLA--EISQTL-----------------------------NNLKNS--NDVSPEIRKLEVR-LKAIQRMTAQQTDRSLALKKEVGDNDAANKRANTDLTQKV C_intestinalis_ENSCINP00000001432 -------YSH---KILQRQLQ--EMKNAVE-----LEMRK-----------------RESDRDG--NVLRANITKLEQR-LTALQRMTAQQTDRSLALKKEVGDNDAANKRANTELTQKV C_intestinalis_ENSCINP00000003143 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001368 KVKLHEEAAV---CHHVLLVL--KSSAHLEQQVVFVQKEA-----------------LLRQQEV--QTDTLLLSDLQEQ-LGSVLQQSRSQEHIVATAQAC-----------LDEHRADI C_intestinalis_ENSCINP00000005981 ----------------------------------------------------------------------------------------------------------------IPELNQKL G_gorilla_ENSGGOP00000004192 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQRV-----------IDSQAEKL C_familiaris_ENSCAFP00000031262 LMQEHEVASQ---TTHLNLLL--GCVTPWMAPRGP--GGA-----------ALALERNLSDLQL--QAAVEVAGDLEVD-CYRAPRSDSQDEHTLQRLTKE----------------KPL O_cuniculus_ENSOCUP00000003184 QIKAHEASSA---VQHVNLLK--EWSNSLEKKVSLLQNES-----------------VEKNKSI--QSLHNQICSFEIE-IERQKEMLRNNESKILHLQXX-----------XXXXXXXX A_carolinensis_ENSACAP00000017068 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024090 AMGRHMEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000013849 AIGRHLEEST---KSHLTMMC--------------------------------------------------------------------------------------------------- H_sapiens_ENSP00000262395 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000014759 AIGRHLEDTT---KSHLTMMC--------------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000050075 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000017530 AMGRHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000018468 AMGRHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000012873 ELARHMQEFT---QVHMRMMA--QSIQNISVTATNP---V----------------P---FING--LPFEPALFS---------------HVSRAPYN--C---------------NPEV R_norvegicus_ENSRNOP00000006148 HLARHLQENT---QLHMRLLA--QAVHNVNL-SLRP---C--------------------------------------------------DASSPSRG--C---------------RPED O_latipes_ENSORLP00000005579 AIGRHLEDTT---KSHLTMMC--------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000014326 KVQVHENTEF---SAHVRLVL--EKLCEQTLCSLTMQSRV--------------------------STFSCDRRSVEEQ-------------------------------------RVRI T_guttata_ENSTGUP00000010462 ELARHMQEFT---QVHMRMMA--QSFQNISVTAANP---V----------------P---FING--LPFEPALFS---------------HVSHAAYN--C---------------NPEV T_rubripes_ENSTRUP00000012878 AIGRHLEDTT---KSHLTMMC--------------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000004949 HLARHLQENT---QLHMRLLA--QAVHNVNL-ALRP---C--------------------------------------------------DAASPSRG--C---------------RPED A_carolinensis_ENSACAP00000005007 ELARHWQEFT---QVHMRMMA--QTLRNVHVTNPAS------------------------------GNF---------------------HAMPPSCE--C---------------SPEV M_mulatta_ENSMMUP00000021907 HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--------------------------------------DSG--Y---------------VSEV O_anatinus_ENSOANP00000018657 QLARHLQDDT---QAHMRMMA--QALHSISITALTP---V----------------P---QLDV--LPFDPA------------------SLPRSSSGYDC---------------HPEV P_pygmaeus_ENSPPYP00000003845 HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--------------------------------------DSG--Y---------------ISEV P_troglodytes_ENSPTRP00000006096 HLARHLQENT---QSHMRMLA--QAVHSLSL--------I----------------P--------------------------------------DSG--Y---------------ISEV B_taurus_ENSBTAP00000021630 HLARHLQENT---QSHMRMMA--QAVQTLSL-AVAP---V----------------P---QCTM--PLYDSV------------------PPTRPSSG--R---------------HSEV H_sapiens_ENSP00000316840 HLARHLQENT---QSHMRMLA--QAVHSLSV--------I----------------P--------------------------------------DSG--Y---------------ISEV G_aculeatus_ENSGACP00000025883 RVKLHEDAAV---HRHMLLVL--RSNTHLEQQVEGLREEA-----------------LLMQQEV--QTDGLLLAGLQKT-IRPLLQQKDGRELTVSAAQVN-----------TYQDSYIL M_domestica_ENSMODP00000024756 HLARHLQEDT---LAHMRMMA--QAIENISIAAFNPK--L----------------H---QREA--SSYDTS------------------PLPRTP--------------------YPGP D_rerio_ENSDARP00000056877 GVARHLEEAA---PTHLSLLC--------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000010159 HLARHLQENT---QSHMRMLG--QAVQSLSL-ALAP---V----------------P---QRDV--PPYDSS------------------SVSRVSST--C---------------HPEV G_aculeatus_ENSGACP00000022648 NLAQHMQEFT---QMHMRYMA--EFLRGLSLNGTTP---K----------------SLWAPAPS--AYPEDQGATAALAAVCSGP--RGAPSSMSSNS--CAPSQ----------PAEGM T_rubripes_ENSTRUP00000041697 DLARHMQDFT---QMHMHYMA--DFLRGLNLNGTTP---K----------------PLGAIGHS--ISFEDHGASAS-----------SCDKGVSSSN--CAPCQ----------PNEET X_tropicalis_ENSXETP00000042386 KIKEHYRTSA---AAHLSLVC--PLILRIKDNLTNTEDST-------------DGPGQKNPFSLQAEDFKAGNGDLELDCGHAVGQPSDEVA-------------------------NRL T_nigroviridis_ENSTNIP00000012472 DLARHMQDFT---QMHMHYMA--DFLRSLNLNGTIP---K----------------DQGA------------AASAS-----------SCSKGALSSN--CTPCQ----------PTEEM M_mulatta_ENSMMUP00000028200 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000015252 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000036715 ELAQHMQEFT---QMHMRYMA--EFLRSQTLNNCTM---P----------------S-------------------AAAHLSSDD--RGA-SARSPDS--C---Q----------CKQEL E_caballus_ENSECAP00000009502 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000009119 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000016445 DLARHLQEFT---QAHMRMMA--QTLRSFSS-SVTPTSHM----------------PDISFCDP--SQFEPAPPSVA-----------TVHSSHTPSQNDC---------------TQET B_taurus_ENSBTAP00000016271 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000001290 NLAQHMQEFT---QMHMRYMD--IRMTTLTKKTKTT---K----------------NALIVIYF--FFPKICVFLVQLQHRLRGSSTRSAASQLILQS--C---EFTLYSHSKRLVKNCF G_gorilla_ENSGGOP00000016344 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000056667 TISRHLEENM---RAHLSMMS--------------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000018618 HLARHLQENT---QSHMRMLA--QAVQSLSL-ALAP---V----------------P---QRDM--LPYDSA------------------PLSRVSSG--C---------------YPEV T_nigroviridis_ENSTNIP00000019321 AIGRHLEDTT---KSHLTMMC--------------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000000748 AMARHVEESV---KPHLAMMC--------------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000021905 HLSHHLQE-T---PCHTRMLT--QAVHSLSL--------I----------------P--------------------------------------DSG--Y---------------ISEA C_intestinalis_ENSCINP00000003738 KMATHVDECF---RKHVSLLC--DGFRK-------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000028670 LPDFRTRPTRREHRNHLFFFFFKKKQRETKKRHTTTKKFLEDGWIDRSDRRVRSGPPSSRALSSGPPRASAGADTGSSGWTRSPSPVGLTGSAPVFRMRDPRPGEATPLAFSSGGAGPIL O_cuniculus_ENSOCUP00000010330 HLARHLQEKT---QLHMRMLA--QAVHSLNL-ALTP---I----------------P--------------------------------------DSG------------------YPEG C_elegans_F45G2.6 SIQQHLSDEP---VRHLMYLC--------------------------------------------------------------------------------------------------- D_melanogaster_FBpp0111838 MLEAHLESNA---AAHLSLMV--------------------------------------------------------------------------------------------------- A_gambiae_AGAP010017-PA LLEAHLEANT---SAHLSLMV--------------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000019424 AMSRHLEDSV---KLHLGLTW--------------------------------------------------------------------------------------------------- A_aegypti_AAEL006649-PA LLEAHLESNT---SSHLSLMV--------------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000027741 PLAPLVPEASYADQAHGGSCC--------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000008928 HLERHLTEAN---ASHIRAMF--------------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000012479 XXQEHEHSAL---REHMRLVL--EKNVQLEEQISDLHKSL-----------------EQKESKI--QQLAETIKKLEKE-FKQFAQLFGKNGSFLPNIQVF------------ASHIDKS O_latipes_ENSORLP00000024257 DMRQHESSFA---AEHLKMMA--TRTGLLETKVEEVKGEL-----------------MERYKVL--PALSTRLSDLESQ-TDDLREKNRQMEQKLAAMQKL-----------MSSHTEKL G_gorilla_ENSGGOP00000005734 HLARHLQENT---XSXMRMLA--QAVHSLSL--------I----------------X--------------------------------------XSG--Y---------------ISEV A_gambiae_AGAP003004-PA AMSAHIASDC---QQHLQVAR--SPCVSALTVTKFEFSPF-------TICSYCSRRGSNDRYKFWDPPAKNSVPEMSTN----------------------------------------- D_rerio_ENSDARP00000040549 KVQVHENTEF---SAHVRLVL--ESNTKLEKQ---------------------------------------------------------------------------------------- D_melanogaster_FBpp0074051 MEEETNRKAFAIEQNQLDVQY---CCDITQSLKEQVESRL--------------------------DEAQKLVNQLSADVTYHQNQLNDNILKLEELI------------------FENE A_aegypti_AAEL015342-PA INEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRI--------------------------NRVGELAGRDEVDKPKDAKLVMIESRLNYLQT------------------EVET A_aegypti_AAEL011363-PA INEETDSRCVDVERCKLDINRLMREYERIEAWRLELTTRI--------------------------NRVGELAGRDEVDKPKDAKLVMIESRLNYLQT------------------EVET D_melanogaster_FBpp0071136 QLEEHLKADM---PHHMQLML--QAFQQTAIATWQPHKPS---------TSGAAVENGHGQQQLPPPPQYANGVD--------------------------------------------- 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD--------------------------------QDKIEALSSK--------------------------VQQL-----E P_troglodytes_ENSPTRP00000036949 ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD--------------------------------QDKIEALSSK--------------------------VQQL-----E P_pygmaeus_ENSPPYP00000022191 ESLENKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD--------------------------------QDKIEALSSK--------------------------VQQL-----E M_mulatta_ENSMMUP00000015132 ENLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD--------------------------------QDKIEALSNK--------------------------VQQL-----E E_caballus_ENSECAP00000011150 EALERKTATFENI---VCVLNREVERV-AMTAEACGRQHRLD--------------------------------QDRIEALSNK--------------------------VQQL-----E C_familiaris_ENSCAFP00000028895 EALERKTATFENI---VCVLNREVERV-AMTAEACGRQHQLD--------------------------------QDRIEALSNK--------------------------VQQL-----E M_musculus_ENSMUSP00000109872 QILEQKIATFENI---VCVLNREVERV-AVTAEACSRQHRLD--------------------------------QDKIEALSNK--------------------------VQQL-----E B_taurus_ENSBTAP00000013869 EALERKTATFENI---VCVLNREVERV-AVTAEACGRQHRLD--------------------------------QDRIEALSNK--------------------------VQQL-----E M_domestica_ENSMODP00000021625 ETLERKTVTFENI---VCVLNREVERV-SMTAEACSRQHRLD--------------------------------QEKIETLSSK--------------------------VQQL-----E G_gallus_ENSGALP00000014649 DALEKKTVTFENI---VCVLNREVERV-SLTAEAYSRQHRLD--------------------------------QEQIETLSNK--------------------------VRQL-----E R_norvegicus_ENSRNOP00000058607 QILEQKIATFENI---VCVLNREVERV-AVTAEACSRQHRLD--------------------------------QDKIEALSNK--------------------------VQQL-----E G_gorilla_ENSGGOP00000006994 ESLEKKTATFENI---VCVLNREVERV-AMTAEACSRQHRLD--------------------------------QDKIEALSSK--------------------------VQQL-----E T_nigroviridis_ENSTNIP00000016461 TELEVKANTFENV---VCVLNREVERF-ATTMEASNRQHKLD--------------------------------QDKIEALSNK--------------------------VRQL-----E T_guttata_ENSTGUP00000002510 EALERKTVTFENI---VCVLNREVERV-SLTAEAYSRQHRLD--------------------------------QEKIETLSNK--------------------------VRQL-----E G_aculeatus_ENSGACP00000006974 QELELKVGTFENI---ACVLNREMERS-CSTMEAYNRQHRLD--------------------------------QDKIEILNNK--------------------------VRQL-----E O_latipes_ENSORLP00000003220 SRLEVKSGTFENV---VCVLNREVERF-TTTMEASNRQHKLD--------------------------------QDKIEALSNK--------------------------VRQL-----E T_rubripes_ENSTRUP00000011363 QDLELKVRTFENI---VCVLNREVERS-CTTMEAYNRQHRLD--------------------------------QDKIEILNNK--------------------------VRQL-----E O_latipes_ENSORLP00000020860 QELELKVSTFENI---VCILNRELERS-CATMEAYNRQHRLD--------------------------------QDKIEILSNK--------------------------VRQL-----E T_rubripes_ENSTRUP00000015632 TELEVKANTFENV---VCVLNREVERF-ATTMEASNRQHKLD--------------------------------QDKIEALSNK--------------------------VRQL-----E T_nigroviridis_ENSTNIP00000013509 QELEVKVSTLENI---ACVLNREVERS-CTTMDAYNRQHRLD--------------------------------QDKIEILNNK--------------------------VRQL-----E D_rerio_ENSDARP00000043465 QELELKVNTFENI---VCVLNREMERS-ATTMEAYNRQHRLD--------------------------------QDKIEILNNKIESNQGIKCEADNSCFSPRNYWMFVQVRQL-----E D_rerio_ENSDARP00000069217 PGVQKKVTTLENI---VCVLNKEVERS-ALTMEAISRQHRLD--------------------------------QEKIENLSNK--------------------------VRQL-----E X_tropicalis_ENSXETP00000008559 DTLDKKNTTFENI---VSVLNREVERS-SHAAEELARQLRAA--------------------------------QEKVEALTTK--------------------------VRQL-----E G_aculeatus_ENSGACP00000020860 TELEVKAGTFENV---VCVLNREVERF-ATAMEASNRQHKLD--------------------------------QDKIEALSNK--------------------------VRQL-----E T_nigroviridis_ENSTNIP00000011878 VNLEKKVTALERI---VCVLNREVERS-TAMLEAFAHQHALD--------------------------------QEKIENLSTK--------------------------LGQL-----E T_rubripes_ENSTRUP00000047803 VDLEKKVTALENI---ICVLNREVERS-ALKVEAFAHQHCLD--------------------------------QEKIENLVSK--------------------------VGQL-----E O_latipes_ENSORLP00000008989 VDLDKKVSALENI---VCVLNREVERS-SLTLEAFSHQHRLD--------------------------------QEKIENLSNK--------------------------IRQL-----E G_aculeatus_ENSGACP00000022084 LDMEKKVNALENI---VCVLNREVGRN-SVTLEAFSHQHRLD--------------------------------QEKIENLSNK--------------------------LLQL-----E A_carolinensis_ENSACAP00000006987 ------------I---IHYSNWIWGRV-RVTLPSF------------------------------------------LPSLW-Q--------------------------VRQL-----E G_gallus_ENSGALP00000002401 --LENKLHVFENI---VAVLNKEVETS-NLEITAFRRQSELD--------------------------------QNVIRGLELK--------------------------IAEL-----H T_guttata_ENSTGUP00000006737 SELENKLHVFENI---VAVLNKEVESS-NLEIQAFRRQSELD--------------------------------QNVIRGLELK--------------------------IAEL-----H D_rerio_ENSDARP00000091948 DALQQKVQVIENI---ISALNREVEKT-QISVVAMNRDHCNS--------------------------------QQIIQHLEAT--------------------------VAEL-----Q O_anatinus_ENSOANP00000001757 SDLEEKLHVFENI---VAVLNKEVESS-NMAIAASIHQSNLD--------------------------------RDMILRLEQR--------------------------VLDL-----H T_rubripes_ENSTRUP00000013348 LELELELRSLRGL---RDEVE-------NLRGTLESVRTRLNALEQGGRSGSGS--------------------THTLASLEAQ--------------------------MNRH-----D T_nigroviridis_ENSTNIP00000005138 LEVELELRALRGL---RDEVE-------NLRGSLEGFRTRLSALEQGGRGGSGS--------------------THTLASLEAQ--------------------------MNRH-----D G_aculeatus_ENSGACP00000005703 LEVELELRSLRVL---RDEVE-------NLRGTLENVRTRLNTLEQGGRSGTGST-------------------THTLATLENQ--------------------------LKRH-----D X_tropicalis_ENSXETP00000027864 KDLDKEIRNLRQT---GDEAD-------GMKSNYESLQNRLSQLEVMAKNA--A--------------------SWNPGVLETQ--------------------------INRH-----D E_caballus_ENSECAP00000011833 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLESQ--------------------------LSRH-----D D_rerio_ENSDARP00000038596 LEVEMELRELRPLRAMREEVE-------TLRGSVESMRSMVSSLDSSCVNSASG--------------------SHTLASLEQQ--------------------------LTRH-----D P_pygmaeus_ENSPPYP00000007003 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV--------------------ARNTGLLESQ--------------------------LSRH-----D P_troglodytes_ENSPTRP00000003288 AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN---------------------------DQRLAVLEEE--------------------------TNKH-----D C_familiaris_ENSCAFP00000026713 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLESQ--------------------------LSRH-----D A_carolinensis_ENSACAP00000000193 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG--------------------ARNAGLLESQ--------------------------LSRH-----D P_troglodytes_ENSPTRP00000011503 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV--------------------ARNTGLLESQ--------------------------LSRH-----D M_mulatta_ENSMMUP00000038268 AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN---------------------------DQRLAVLEEE--------------------------TNKH-----D M_musculus_ENSMUSP00000021706 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLESQ--------------------------LSRH-----D P_pygmaeus_ENSPPYP00000000253 AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN---------------------------DQRLAVLEEE--------------------------TNKH-----D R_norvegicus_ENSRNOP00000010906 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLESQ--------------------------LSRH-----D G_gallus_ENSGALP00000036699 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG--------------------ARNTSMLETQ--------------------------LSRH-----D O_anatinus_ENSOANP00000023053 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKNAGQA--------------------ARNTGMLETQ--------------------------LSRH-----D H_sapiens_ENSP00000376500 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV--------------------ARNTGLLESQ--------------------------LSRH-----D H_sapiens_ENSP00000336825 AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENN---------------------------DQRLAVLEEE--------------------------TNKH-----D T_guttata_ENSTGUP00000013203 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKTAGQG--------------------ARNTSLLETQ--------------------------LSRH-----D B_taurus_ENSBTAP00000017918 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLESQ--------------------------LSRH-----D M_domestica_ENSMODP00000024498 SELEEKLRVFENI---VTVLNKEVEAS-HLAIAASVHQSGLT--------------------------------QDLILSLEQR--------------------------VVDL-----Q O_anatinus_ENSOANP00000013484 TWLETQVRQLLHM---ANQQQSKFDLK-SLMETIDTVKQKIALLETY---------------------------DQRLVVLKDQ--------------------------TRQH-----D M_domestica_ENSMODP00000016701 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQA--------------------ARNTGLLETQ--------------------------LSRH-----D E_caballus_ENSECAP00000005414 AWLEAQVRQLLQM---ANQQETKFDLR-ALMEAIDTVKQKITLLETH---------------------------DQRIVVLEGE--------------------------TNKH-----D T_guttata_ENSTGUP00000003276 ARLESQVKQLIQM---ANQQQSKLDLQ-PLLDTIENVKQKIALMETY---------------------------DQRLVVLEDQ--------------------------SSKH-----D G_gallus_ENSGALP00000016021 ARLESQVKQLIQM---ANQQQSKLDLR-PLFDTIENVKQKIALMETY---------------------------DQRLAVLESQ--------------------------SSKH-----D A_carolinensis_ENSACAP00000016112 ACLETQVRQLVQM---ANQQQSKFDLR-PLLETVENIKQKVAFLESY---------------------------EQRLVVLEDL--------------------------SSQH-----D B_taurus_ENSBTAP00000015940 AWLEVQVRQLLQM---ANQQQSKFDLK-PLVEAIDTVKQKITLLETN---------------------------DQRLVVLEGE--------------------------TNKH-----D P_troglodytes_ENSPTRP00000036416 AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q H_sapiens_ENSP00000362994 AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q M_domestica_ENSMODP00000003305 AWLETQVRELLEL---ANQQENKLDLK-PLINTIDTIKQKITLLETY---------------------------DQRLVTLEGQ--------------------------TNRH-----D M_musculus_ENSMUSP00000082710 AWLEAQVRQLLQI---VNQQPSRLDLR-SLVDAVDSVKQRITQLEAS---------------------------DQRLVLLEGE--------------------------TSKH-----D M_mulatta_ENSMMUP00000026496 AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q M_musculus_ENSMUSP00000028234 AQLEEKLRVFANI---VAVLNKEVEAS-HLALAASIHQSQLD--------------------------------REHILSLEQR--------------------------VVEL-----Q C_familiaris_ENSCAFP00000017853 AWLEAQVRQLLQM---ANQQQNKFDLR-PLVEAIDTVKQKITLLETN---------------------------DQRLVVLEGE--------------------------TNKH-----D O_cuniculus_ENSOCUP00000007884 XXXXXXXXXXXXX---XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX---------------------------XXXXXVLEGE--------------------------TSKH-----D P_pygmaeus_ENSPPYP00000021917 AELEGKLRVFENI---VAVLNKEVEAS-HLALATSIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q E_caballus_ENSECAP00000009372 AELEGKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD--------------------------------REHILSLEQR--------------------------VLEL-----Q M_mulatta_ENSMMUP00000015419 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV--------------------ARNTGLLESQ--------------------------LSRH-----D O_cuniculus_ENSOCUP00000004916 AELEGKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q B_taurus_ENSBTAP00000041215 NELEGKLCVFENI---VAVLNKEVEAS-HLALAASIHQSQLD--------------------------------REHILSLEQR--------------------------VLEL-----Q G_gorilla_ENSGGOP00000002249 XXXXXXXXVFENI---VAVLNKEVEAS-HLALATSIHQSQLD--------------------------------RERILSLEQR--------------------------VVEL-----Q X_tropicalis_ENSXETP00000031605 MWLEEQV---IQL---VSKEHSRLDLR-PILDTLESTKQRLSTLEAY---------------------------KDRIDNLDGQ--------------------------FKKH-----D C_intestinalis_ENSCINP00000001022 EEIAREIAQIKEK---QNELE-------R-------------KIESTSSSR--E--------------------QMAPENLSQM--------------------------VDAF-----E C_intestinalis_ENSCINP00000027890 EEIAREIAQIKEK---QNELE-------R-------------NIESTSGSR--E--------------------QMAPENLSQM--------------------------VDAF-----E C_intestinalis_ENSCINP00000001432 EEIGREIAQIKEK---QNELK-------R-------------KLESTSSSR--E--------------------QIAPENLSQM--------------------------VDAF-----E C_intestinalis_ENSCINP00000003143 ---------------------------------------------------------------------------MAPENLSQM--------------------------VDAF-----E O_latipes_ENSORLP00000001368 LEMENELLAAETL---REHIGNQTGNSRSVKLRSATLCTGVFLFYIKC--------------------------HLMSATLEEN--------------------------RKRH-----S C_intestinalis_ENSCINP00000005981 KEMIEEMTRIRQK---QNELE-------R-------------KL----STR--N--------------------QENEQNFLAQ--------------------------INGF-----E G_gorilla_ENSGGOP00000004192 KELDKEIRPFRQN---WEEAD-------SMKSSVESLQNRVTELESVDKSAGQV--------------------ARNTGLLESQ--------------------------LSRH-----D C_familiaris_ENSCAFP00000031262 AELQEKLRVFENI---VAVLNKEVEAS-HLALAASIHQSQLD--------------------------------REHILSLEQQ--------------------------VAKA-----L O_cuniculus_ENSOCUP00000003184 XXXXXXXXXXXXX---XXXXX-------XXXXXXXXXXXXXXXXXXXXXXXXXX--------------------XXXXXLLESQ--------------------------LSRH-----D A_carolinensis_ENSACAP00000017068 --------------------------------------------------------------------------------------------------------------VEQQ-----D M_domestica_ENSMODP00000024090 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000013849 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000262395 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000014759 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000050075 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000017530 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018468 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000012873 ENFKETIQQLEGR---LVRQDHQ------------------------------------------------------IRELIAK--------------------------METQ-----N R_norvegicus_ENSRNOP00000006148 PNYEETVKQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S O_latipes_ENSORLP00000005579 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000014326 CSVQRELRDLRVL---GSELKEELPRL-----------------------------------------------QASLDSLRQQ-----------------------------------V T_guttata_ENSTGUP00000010462 ENFKETIQQLEGR---LVRQDHQ------------------------------------------------------IRELIAK--------------------------METQ-----N T_rubripes_ENSTRUP00000012878 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000004949 PNYEETIKQLESR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S A_carolinensis_ENSACAP00000005007 RNFKETIQQLEGR---LVRQDHQ------------------------------------------------------IRELIAK--------------------------METQ-----N M_mulatta_ENSMMUP00000021907 RNFQETIHQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S O_anatinus_ENSOANP00000018657 QNFQETIQQLEGR---LVRQDHQ------------------------------------------------------IRELIAK--------------------------METQ-----S P_pygmaeus_ENSPPYP00000003845 RNFQETIHQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S P_troglodytes_ENSPTRP00000006096 RNFQETIHQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S B_taurus_ENSBTAP00000021630 HNFQETIQQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S H_sapiens_ENSP00000316840 RNFQETIHQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S G_aculeatus_ENSGACP00000025883 GRFPAFLKVVLSL---LSRGSFELE---ELRKSVDAVIQEVSAAEAL---------------------------RRHLGTLEED--------------------------LKQH-----S M_domestica_ENSMODP00000024756 QNFQETIQQLESR---LVIQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S D_rerio_ENSDARP00000056877 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000010159 QNFQETIQQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S G_aculeatus_ENSGACP00000022648 QRLR----EMDGR---LVKQDHQ------------------------------------------------------LRELIIL--------------------------KETQ-----A T_rubripes_ENSTRUP00000041697 QRLR----EMDRR---LVKQDHQ------------------------------------------------------LRELIIL--------------------------KETQ-----A X_tropicalis_ENSXETP00000042386 SLLETRLQVFENI---ISVLSKEIDSS-QSQLAAIKEQKAEE--------------------------------ERKVKALEHK--------------------------VENL-----R T_nigroviridis_ENSTNIP00000012472 QRLR----EMDRR---LVKQDHQ------------------------------------------------------LRELIIL--------------------------KENQ-----T M_mulatta_ENSMMUP00000028200 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000015252 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000036715 LNLRETVLELEGR---LVRQDQQ------------------------------------------------------IRELCIH--------------------------NDTQ-----K E_caballus_ENSECAP00000009502 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000009119 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000016445 RNLRETIEQLEGR---LVRQDHQ------------------------------------------------------IRELIAK--------------------------METQ-----C B_taurus_ENSBTAP00000016271 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000001290 YHLR-NVAKLKPM---LTRSDLELIID-SVKCFKAQGFPSLVKCQNILKTP----KT-----------------QFSLEWVLRH--------------------------KDRKSNHKLA G_gorilla_ENSGGOP00000016344 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000056667 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000018618 RNFQETIQQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S T_nigroviridis_ENSTNIP00000019321 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000000748 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000021905 RNFQETSHQLEDR---LVGQDNQ------------------------------------------------------IQELTDE--------------------------IETQ-----S C_intestinalis_ENSCINP00000003738 --------------------------------------------------------------------------QAELLGLQKK------------------------------------ O_anatinus_ENSOANP00000028670 GTFKKKKTTNQTT---EQTQTGGGGGV-SVSSLSFAFLRGADPVKGVSRNPPPTERGPRSGGPVARRGREGREGRAPATVSNRQ--------------------------VQQL-----E O_cuniculus_ENSOCUP00000010330 HNFQETIQQLEGR---LVRQDHQ------------------------------------------------------IRELTAK--------------------------METQ-----S C_elegans_F45G2.6 ---------------------------------------------------------------------------DEITDLKGT--------------------------YELM-----E D_melanogaster_FBpp0111838 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP010017-PA ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000019424 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL006649-PA ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000027741 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000008928 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012479 AWLEAQVHQLLQM---VNQQQNKFDLR-PLMEAVDTVKQKITLLENS---------------------------DQRLAVL--------------------------------------- O_latipes_ENSORLP00000024257 LELELELRSLRQL---RDEME-------SLRGTLDTVRTRLSALEHSCINTQS------------------------------------------------------------------- G_gorilla_ENSGGOP00000005734 RNFQEXIHQLEGR---LVRQXHQ------------------------------------------------------IRELTXK--------------------------METQ-----S A_gambiae_AGAP003004-PA ----ELVRSMYER----------------------------------------------------------------IVILEQE--------------------------VHIL-----G D_rerio_ENSDARP00000040549 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074051 RLNREKFFQIEEF---LQQINEDIKTKLGNSDYVTSKQATLDYEVKNV--------------------------KNIVCETEER--------------------------CDKL-----D A_aegypti_AAEL015342-PA LREEQKDRKGDEK---AQEGNELVKGKIGVGDEQLDKQAKLDYELKGV--------------------------LNTVNETEDK-------------------------SLEKY-----R A_aegypti_AAEL011363-PA LREEQKDRKGDEK---AQEGNELVKGKIGVGDEQLDKQAKLDYELKGV--------------------------LNTVNETEDS--------------------------LEKY-----R D_melanogaster_FBpp0071136 ---EQIVQTMYQR----------------------------------------------------------------IVVLEQR--------------------------TREQ-----E 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRI--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM P_troglodytes_ENSPTRP00000036949 RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM P_pygmaeus_ENSPPYP00000022191 RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM M_mulatta_ENSMMUP00000015132 RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM E_caballus_ENSECAP00000011150 RSIGLKDLAMADLEQKVH--E--MEASTFD-GVFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHVSLFF-VVMKGPNDALLRWPFNQK---VTLM C_familiaris_ENSCAFP00000028895 RTIGLKDLAMAELEQKVH--E--MEASTFD-GVFIWKISDFARKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM M_musculus_ENSMUSP00000109872 RSIGLKDLAMADLEQKVS--E--LEVSTYD-GVFIWKISDFTRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLQWPFNQK---VTLM B_taurus_ENSBTAP00000013869 RSIGLKDLAMADLEQKVL--E--MEASTFD-GVFIWKISDFSRKRQEAVAGRT--PAIFSPAFYTSRYGYKMCLRAYLNGDGTGR-GTHLSLFF-VLMRGPHDALLRWPFNQK---VTLM M_domestica_ENSMODP00000021625 RSIGLKDLAMADMEQKIL--E--MEASTYD-GIFIWKITDFARKRQEAMAGRS--PAIFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM G_gallus_ENSGALP00000014649 RSIGLKDLAMAEMEEKIR--N--MEASTYD-GVFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM R_norvegicus_ENSRNOP00000058607 RSIGLKDLAMADLEQKVS--E--LEVSTYD-GVFIWKISDFARKRQEAIAGRT--PAIFSPGAVCVLRMLLMLLNVYLQGRGTGR-QTHLSQLS-VCARAYWAVVLQWLLTEQ---VTLM G_gorilla_ENSGGOP00000006994 RSIGLKDLAMADLEQKVL--E--MEASTYD-GVFIWKISDFARKRQEAVAGRT--PAIFSPXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX-XXXXXXXXXXXXXXXXXX---VTLM T_nigroviridis_ENSTNIP00000016461 RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGQSDALLKWPFNQK---VTLM T_guttata_ENSTGUP00000002510 RSIGLKDLAMAEMEEKIR--N--MEASTYD-GVFIWKITEFARKRQEAITGRS--PAIFSPAFYTSKYGYKMCLRVYLNGDGTGR-GTHLSLFF-VVMKGPNDALLRWPFNQK---VTLM G_aculeatus_ENSGACP00000006974 RTVSLRDLSIVEMEGKMR--D--MSAATYD-GIFVWKISDFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM O_latipes_ENSORLP00000003220 RTVGLKDLTVAEMEGRLR--E--MAATTFD-GVFIWRISDFAKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGLSDALLKWPFNQK---VTLM T_rubripes_ENSTRUP00000011363 RTVSLRDLSIVEIDEKMR--E--LSAATYD-GVFVWKISDFTKKRQDAVAGRA--PAMFSSAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM O_latipes_ENSORLP00000020860 RTVSLRDLSIVEMEGKMK--D--MSAATYD-GIFIWKISDFTKKRQDAMAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM T_rubripes_ENSTRUP00000015632 RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGQSDALLKWPFNQK---VTLM T_nigroviridis_ENSTNIP00000013509 RTVSLRDLSIVEMDEKMR--E--LSAATYD-GVFVWKIADFTKKRQDAVAGRA--PAMFSPAFYTSKYGYKMC-RIYLNGDGTGR-GSHLSLFF-VVMRGHSDALLKWPFNQK---VTLM D_rerio_ENSDARP00000043465 RTVGLRDLSIVEMEAKMR--E--MSAATYD-GVFVWKISDFSKKRQDAVAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGHSDALLKWPFNQK---VTLM D_rerio_ENSDARP00000069217 RTLTTRDLQLAESEQSLR--E--LQFCTYD-GVFIWKIAEFSRRRQDAVAGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GSHLSLFF-VVMKGKYDALLKWPFSQK---VTLM X_tropicalis_ENSXETP00000008559 RTLGQKELIVAELETRMQ--E--SELSTYD-GVFIWKISEFGKKRQDAINGRC--PAMFSPPFYTNKYGYKMCLRIYLNGDGTGR-NTHLSLFF-VVMKGNNDALLRWPFNQK---VTLM G_aculeatus_ENSGACP00000020860 RTVGLKDLTVAEMEGRLR--E--MSATTFD-GVFVWRISDFAKKRQDAIAGRA--PAMFSPAFYTSKYGYKMCLRIYLNGDGTGR-GSHLSLFF-VVMRGLSDALLKWPFNQK---VTLM T_nigroviridis_ENSTNIP00000011878 RVIAMRDLQLSETEQMVR--E--LQSCTYD-GIFVWKISEFSRRRQEAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMKGKCDALLKWPFSQK---VTLM T_rubripes_ENSTRUP00000047803 RAIAMRDLQLSETEQMVR--E--LQSCTYD-GIFVWKISEFSRRRQEAVAVRM--PTMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRGKCDALLKWPFSQK---VTLM O_latipes_ENSORLP00000008989 RSLTVKDLQLSEAEQMVR--E--LQYCTYD-GIFVWKITDFSHRRQEAVSGRA--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRSKYDALLKWPFSQK---RTIW G_aculeatus_ENSGACP00000022084 RTVSMKDLQLSATDQLLK--E--LQFCTYD-GIFVWKISDFSRRRQDAVAGRT--PAMFSPAFYSSKYGYKMCLRLYLNGDGTGR-GTHLSLFF-VVMRGKCDALLKWPFSQK---VTLM A_carolinensis_ENSACAP00000006987 RSLASKDLALAEMEHSLQ--E--MEAASFD-GIFIWKISDFTKKRQ-AVAGRS--PAIFSPAFYTGKYGYKMCLRIYLNGDGTGR-GTHLSLFF-VVMRGPCDALLRWPFNQK---V--- G_gallus_ENSGALP00000002401 HCLTQKDAGLSRLHKSLV--F--SEQTSYD-GVFLWKITDVNQKLQDSVTGRV--VSLYSPAFYTAKYGYKVCLRIYLNGDGMGK-GTHVSLFF-VVMKGDYDALLPWPFRHK---VTFM T_guttata_ENSTGUP00000006737 QCLTQKDAGLSSLHKSLL--F--SEQASYD-GIFLWKITEVARKLQDSVTGRT--VSLYSPAFYTAKYGYKVCLRVYLNGDGTGK-GTHMSLFF-VVMKGDYDALLPWPFRHK---VTFM D_rerio_ENSDARP00000091948 QRLVRKDILISSLQQSIS--A--QQDVSYD-GTFYWRVCDVSQKQREAANSQK--ISQYSPAFYTARYGFKVCLRLYLNGDGAGK-GSHISLFF-VIMKGEYDPILSWPFKHK---VTFF O_anatinus_ENSOANP00000001757 QTLAQKDLALARLKQSLQ--F--SELASYD-GIYLWKITDFSRKCHESLCGRT--TSLFSPVFYTARYGYKVCLRVYLNGDGTGK-GTHISLFF-VIMKGEYDSLLQWPFRNK---VTFM T_rubripes_ENSTRUP00000013348 DMLSVHDIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM T_nigroviridis_ENSTNIP00000005138 DMLSVHDIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVAAKT--LSLYSQPFYTGYFGYKMCARIYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM G_aculeatus_ENSGACP00000005703 EMLSVHEIRLADMDLRFQ--V--LETASYN-GTLIWKIRDYKRRKQEAVGAKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VVMRGEYDALLPWPFKQK---VTLM X_tropicalis_ENSXETP00000027864 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VSLM E_caballus_ENSECAP00000011833 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM D_rerio_ENSDARP00000038596 DLMSVHDVRLAEMDLKLQ--V--LETASFN-GTLIWKIRDYKRRKQEAVVSKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VVMRGEYDALLQWPFKQK---VTLM P_pygmaeus_ENSPPYP00000007003 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM P_troglodytes_ENSPTRP00000003288 THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM C_familiaris_ENSCAFP00000026713 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM A_carolinensis_ENSACAP00000000193 QMLSVHDIRLADMDLRFQ--V--LETASYN-GILIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM P_troglodytes_ENSPTRP00000011503 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM M_mulatta_ENSMMUP00000038268 THINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTGRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM M_musculus_ENSMUSP00000021706 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM P_pygmaeus_ENSPPYP00000000253 THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM R_norvegicus_ENSRNOP00000010906 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM G_gallus_ENSGALP00000036699 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM O_anatinus_ENSOANP00000023053 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM H_sapiens_ENSP00000376500 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM H_sapiens_ENSP00000336825 THINIHKAQLSKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAVDGHT--VSIFSQSFYTSRCGYRLCARAYLNGDGSGR-GSHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM T_guttata_ENSTGUP00000013203 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM B_taurus_ENSBTAP00000017918 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM M_domestica_ENSMODP00000024498 QTLTQKDLALTKLEQTLH--L--LEEASYD-GVYLWKITNFTRRCHESACGRT--VSLFSPAFYTARYGYKLCLRIYLNGDGMGK-GTHLSLFI-VVMKGKYDALLEWPFRNKAIPVTFM O_anatinus_ENSOANP00000013484 AHINAHKAQLNKNEERFK--L--LEGTCYN-GKLIWKVTDYKMKKREAMEGRS--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMKGEFDSLLQWPFKQK---VTMM M_domestica_ENSMODP00000016701 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM E_caballus_ENSECAP00000005414 VHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKREALEGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM T_guttata_ENSTGUP00000003276 LQINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKITDYQKKKREAVEGRV--LSIASQPFYTSRCGYRLCARAYLNGDGSGK-GTHISLYF-VVMRGEFDSLLLWPFKQK---VTLM G_gallus_ENSGALP00000016021 LQINIHKAQLNKNEERFK--L--LEGTCYN-GKLIWKITDYKMKKKEAVEGRV--LSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHVSLYF-VVMRGEFDSLLPWPFKQK---VTLM A_carolinensis_ENSACAP00000016112 IHLGLHKAQLNKNEERFK--L--LEGTSYN-GKLIWKIVDYKTKKKEAVEGSC--LSIFSQPFYTSRCGYRLSTRAYLNGDGSGK-GTHVSLYF-VVMRGEFDSLLPWPFRQK---VTLM B_taurus_ENSBTAP00000015940 AHINIHKAQLNKNEERFK--L--LESACYN-GKLIWKVTDYKLKKKEALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM P_troglodytes_ENSPTRP00000036416 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--ISLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM H_sapiens_ENSP00000362994 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM M_domestica_ENSMODP00000003305 VHINVHKAQLNKNEERFK--M--LEGTCYN-GKLIWKVTDYKMKKKEATEGRT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMKGEFDSLLQWPFKQR---VTMM M_musculus_ENSMUSP00000082710 AHINIHKAQLNKNEERFK--Q--LEGACYS-GKLIWKVTDYRVKKREAVEGHT--VSVFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM M_mulatta_ENSMMUP00000026496 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM M_musculus_ENSMUSP00000028234 QTLAQKDQVLGKLEHSLR--L--MEEASFD-GTFLWKITNVTKRCHESVCGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGSGK-KTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM C_familiaris_ENSCAFP00000017853 AHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKREALDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM O_cuniculus_ENSOCUP00000007884 AHINIHKAQLNKNEERFK--L--LEGACYN-GKLIWKVTDYKMKKKEAVDGHT--VSIFSQPFYTSRCGYRLCARAYLNGDGSGK-GTHLSLYF-VVMRGEFDSLLQWPFRQR---VTLM P_pygmaeus_ENSPPYP00000021917 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VLMRGEYDALLPWPFRNK---VTFM E_caballus_ENSECAP00000009372 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM M_mulatta_ENSMMUP00000015419 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM O_cuniculus_ENSOCUP00000004916 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCLESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM B_taurus_ENSBTAP00000041215 QTLAQKDQALGKLEQSLR--L--VEEASYD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPKKGE---VTFM G_gorilla_ENSGGOP00000002249 QTLAQKDQALGKLEQSLR--L--MEEASFD-GTFLWKITNVTRRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM X_tropicalis_ENSXETP00000031605 VLLSNHKMQMTSNEERFR--L--VEGTSYN-GKLIWKITDYERKKREAMEGRA--VSIFSQHFYTSWCGYRLCARAYLNGDGSGK-GSFLSLYF-VVMKGEFDSILLWPFKQK---VTLM C_intestinalis_ENSCINP00000001022 RQLGMYDVRIADMDQRFQ--V--LETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM C_intestinalis_ENSCINP00000027890 RQLGMYDVRIADMDQRFQ--V--IETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM C_intestinalis_ENSCINP00000001432 LQLGMYDVRIADMDQRFQ--V--IETTSYS-GFLIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM C_intestinalis_ENSCINP00000003143 RQLGMYDVRIADMDQRFQ--V--IETTSYS-GVVIWKIRDFSRRKREAVSGRT--LSLYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHMSLFF-VVMKGEYDALLPWPFRQK---VTLM O_latipes_ENSORLP00000001368 GLLELHVAQLALNKQHLQ--E--LELTSYD-GRLIWKIKDFQKRREAEATGQH--PCLSSVPFHTGRCGYKMAMKAYLNGDGEGR-GTHLSLYV-VLMPGDFDALLPWPFKQT---VSLS C_intestinalis_ENSCINP00000005981 QQIGLYDVRIADMDQRFQ--V--LETTSYS-GVALWKINNFQPRKREAESGRA--LSIYSQPFYTSRYGYKMCARVYLNGDGMGK-GTHVSLFF-VLMKGEYDNLLPWPFRQK---VTLM G_gorilla_ENSGGOP00000004192 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM C_familiaris_ENSCAFP00000031262 HLCAVKAQWSVLPLLSHR--E--QEDHSFVWARSWWKITNVTFRCHESACGRT--VSLFSPAFYTAKYGYKLCLRLYLNGDGTGK-RTHLSLFI-VIMRGEYDALLPWPFRNK---VTFM O_cuniculus_ENSOCUP00000003184 QMLSVHDIRLADMDLRFQ--V--LETASYN-GVLIWKIRDYKRRKQEAVMGKT--LSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFF-VIMRGEYDALLPWPFKQK---VTLM A_carolinensis_ENSACAP00000017068 SLLAVKDVMISNLASRIH--T--LEQTTYD-GCLLWKIPEVGLRSREARTGNR--PACYSPAFYTSRYGYKVCLKVFLNGEGTGT-GTHLSLFL-VLMKGEYDFQLKWPFRHK---VTFT M_domestica_ENSMODP00000024090 ALVSRQRQELQELRRDVE-----ELSVGCD-GVLIWKIGGYGRRLQEAKARAN--HECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS D_rerio_ENSDARP00000013849 SLVGRQRQEILELRREME-----ELSVSHD-GVLIWKLTDYSRKLQEAKLRNN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSIYI-RVLPGEYDNLLEWPFSYK---VTFS H_sapiens_ENSP00000262395 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS G_aculeatus_ENSGACP00000014759 NLVGRQRQEILELRREME-----ELSVSHD-GVLIWKLSDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDSLLEWPFSYK---VTFS B_taurus_ENSBTAP00000050075 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS M_musculus_ENSMUSP00000017530 ALVSRQRQELQELRRELE-----ELSIGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI-RVLPGAFDNLLEWPFARR---VTFS R_norvegicus_ENSRNOP00000018468 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSIYI-RVLPGAFDNLLEWPFARR---VTFS G_gallus_ENSGALP00000012873 THMAELKRTIRDLEGKIT--E--MEAQQCN-GIYIWKIENFSGLQKAQEEERP--VVMHSPGFYTGKPGYKLCLRLHIQLPSAQRCANFISLFV-HTMQGEYDSHLPWPFQGT---IRLS R_norvegicus_ENSRNOP00000006148 MHVSELKRTIRSLEDKVA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT O_latipes_ENSORLP00000005579 NLVSRQRQEILELRREME-----ELSVSHD-GVLIWKLNDYSRKLQEAKLRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS D_rerio_ENSDARP00000014326 AVTESLREHLVALKQHST--F--LESSSYD-GKLIWKVRDYWHRKESG-------AALSSSPFYTSRSGYKLSVRAYLGGDGSGR-GSHMSLYI-TIMRGDFDSFLPWPFRQN---ITLT T_guttata_ENSTGUP00000010462 THMAELKRTIRNLEGKIT--E--MEAQQCN-GIYIWKIENFSGLQRAQEEERP--VVLHSPGFYTGKPGYKLCLRLHIQLPNAQRCANFISLFV-HTMQGEYDSHLPWPFQGT---IRLS T_rubripes_ENSTRUP00000012878 NLVGRQRQEILELRREME-----ELSVGHD-GILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS M_musculus_ENSMUSP00000004949 MYVGELKRTIRTLEDKVA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEERP--VVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT A_carolinensis_ENSACAP00000005007 SQVGDLKGTIKNLEEKIT--E--LEAQQCN-GIFIWKIEHFSVYLKALEEERP--VVIHSPGFYTGKPGYKLCMRLHIQLPNVQRCANYISLFV-HIMQGEYDNYLPWPFQGT---IRLS M_mulatta_ENSMMUP00000021907 TYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT O_anatinus_ENSOANP00000018657 SHVVDLKRTIRTLEDKIA--E--MEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPNAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT P_pygmaeus_ENSPPYP00000003845 MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT P_troglodytes_ENSPTRP00000006096 MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT B_taurus_ENSBTAP00000021630 MYVNELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT H_sapiens_ENSP00000316840 MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT G_aculeatus_ENSGACP00000025883 GLLDLHAAQLGGNERHLR--E--LGGASFD-GRLIWKIDDFTNRREAEVRGRP--PCLSSVPFHAGTCGYKLASRVYLNGDGEGR-GTHLSLYV-VLMPGDFDALLPWPFRQT---VSLS M_domestica_ENSMODP00000024756 ACVGDLKRTIRTLEDRIA--E--MEAQQCN-GIYIWKINNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPSAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT D_rerio_ENSDARP00000056877 GLVNRQRLELRDLRRRME-----ELSGSRD-GTLLWKLTDFSQRLQEAKTRTSGCLELFSPAFYSHNYGYRLQVSAFLNGNGSGE-DTHMSVYL-RVLPGEYDGLLEWPFPYR---VSFS C_familiaris_ENSCAFP00000010159 MHVSELKRNIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLA G_aculeatus_ENSGACP00000022648 GQLAELRRRVSLLEDTVK--E--LESQQCH-GIFIWRLRGFSAHLRNQEAGQP--VVEHSPGFYTGRPGYKLCLRLHLQTPNAPRCSNFISLFV-HTMQGAFDGQLSWPFQGT---IRLA T_rubripes_ENSTRUP00000041697 GQLAELGRRVSMLEETVR--E--LESQHCT-GIFIWRLKDFSVLLRNQEAGLP--VVEHSPAFYTGRPGYKLCLRLHLQSPNAQRCSNFISLFV-HTMQGAFDGRLTWPFQGT---IRLA X_tropicalis_ENSXETP00000042386 CTLAMKDIVLNELEMRSA--C--LEQTSYD-GVFLWKISDLTNKSHDAVTGRA--ISLYSPVSPSFK-GKSIPSLFPVSLSFKGKSTPHCFLFHPVSRRSQSPSLFPVSLSFK---VTFV T_nigroviridis_ENSTNIP00000012472 GQIAELRKRVSVLEESMR--E--LESQHCT-GIYIWRLKDFSVLLRNQEAGLP--VVEHSPGFYTGRPGYKLCLRLHLQSPVAQRCSNFISLFV-HTMQGAYDGLLTWPFQGT---IRLA M_mulatta_ENSMMUP00000028200 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS P_troglodytes_ENSPTRP00000015252 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS D_rerio_ENSDARP00000036715 NQVTELRRKLVSLEESTR--E--LEAQQYQ-GIYVWRVENFSHHLRNQEAGQP--IVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFV-HTMQGEFDSQLSWPLQGT---IRLA E_caballus_ENSECAP00000009502 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS P_pygmaeus_ENSPPYP00000009119 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS X_tropicalis_ENSXETP00000016445 TYVNELKHTIRSLDNRLG--E--MESQQCS-GIFIWRINNFNSLLKNQEEERP--VVIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFV-HTMQGEYDSLLPWPLQGT---IRLS B_taurus_ENSBTAP00000016271 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS O_latipes_ENSORLP00000001290 GQLAELRRRVSVLEETVK--E--LEAQQYH-GIFIWRLKAFSTHLRSQEAGIP--VVEHSPGFYTGRPGYKLCLRLHLQTPTAPRCSNFISLFV-HTMQGVFDSQLTWPFQGT---IRLA G_gorilla_ENSGGOP00000016344 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS X_tropicalis_ENSXETP00000056667 SLVSRQRQEILELRKQVE-----ELSVSSE-GVLIWKISDYSRKVQEAKVRGN--FESFSPPFYTHKYGYKLQVSAFLNGNGSGE-GSYLSVYI-RVLPGEYDNLLEWPFSYR---VTFS E_caballus_ENSECAP00000018618 IYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT T_nigroviridis_ENSTNIP00000019321 NLVGRQRQEILELRREME-----ELSVSHD-GILIWKLNDYSRKLQEAKIRSN--HEFFSPPFYTHRYGYKLQVSAFLNGNGSGE-GSHLSVYI-RVLPGEYDNLLEWPFSYK---VTFS O_cuniculus_ENSOCUP00000000748 ALVSRQRQELQELRRELE-----ELSVGSD-GVLIWKIGSYGRRLQEAKAKPN--LECFSPAFYTHKYGYKLQVSAFLNGNGSGE-GTHLSLYI-RVLPGAFDNLLEWPFARR---VTFS M_mulatta_ENSMMUP00000021905 IYVSE----IRTLEDKVA--D--IEAQQCN-GIYIWKIGS---HLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLLTAQRCANYISLFV-HTMQGEYDSHLPWPF-GT---ICLT C_intestinalis_ENSCINP00000003738 -QLFEHKQILHDHGKMVR--NGIFSNIEFD-SQLLWKISEWSSKKIEAEAGKR--TVLQSPLFYSARFQYKLAVLLLPNGDGKAK-GTHLSIYV-RLCKGEYDALLSWPYRLP---IEIS O_anatinus_ENSOANP00000028670 RSIGLKDLAMADMQQQIH--D--MEASTYD-GIFIWKITDFARKRQEALAGRS--PAIFSP----------------------------------------------------------- O_cuniculus_ENSOCUP00000010330 MYVSELKRTIRTLEDKVA--E--IEAQQCN-GIYIWKIGNFGMHLKSQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT C_elegans_F45G2.6 RDMGSFNDRQTRILSAAE-----TCTEMFG-PQLIWKIDKLQQRTNEAKSGAD--TTIFSVPFMSHRFGYKMMACACLFGDGSSA-GKSISLYV-LLLKGEFDPTLEWPFHRA---IKIS D_melanogaster_FBpp0111838 ALSSRQGQQIQMLKSAVS-----KLSINYT-GTLLWKITDWSAKMAEARGKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-NTHVSVYI-KVLPGEYDALLKWPFSHS---ITFT A_gambiae_AGAP010017-PA ALSGRQGQQINMLKSAMA-----KLSTNYT-GTLLWKITDWSVKMQEAKTKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI-KVLPGEYDALLKWPFSHS---VTFT O_anatinus_ENSOANP00000019424 ALVSRQRQELQELRRDVE-----ELAAGSD-GVLVWRIGGYGRRLQEARGRPN--HECLSRPFYTHKYGYRLQVSAFLNGNGSGE-GTHLSLYI-RVLPGDYDNLLEWPFALR---VTFS A_aegypti_AAEL006649-PA ALSGRQGQQINMLKNAMA-----KLSTNYT-GTLLWKITDWSAKMVEAKSKDG--LELVSPPFYTSQYGYKLQASMFLNGNGPGE-GTHVSVYI-KVLPGEYDALLKWPFSHS---VTFT C_familiaris_ENSCAFP00000027741 EAATGLLSALYLPRSELG-----TCSSPRE-PPWAWSAYEAS-----GTKGANGKEEDQNIRAFVSCYGYII----ILENPITPI-NHHSSLYI-RVLPGAFDNLLEWPFARR---VTFS C_intestinalis_ENSCINP00000008928 DLVKTQRSHISELQKQLS-----DLTVNTN-GTLLWKIPGYSQKLQAAQKDQA--IEMRSPPFYTHRYGYKLQLSAFLNGNGSGL-NSHMSLY--------------------------- G_gorilla_ENSGGOP00000012479 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000024257 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005734 MYVSELKRTIRTLEDKVA--E--XEAQQCN-GIYIWKIGNFGMHLKCQEEEKP--VVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFV-HTMQGEYDSHLPWPFQGT---IRLT A_gambiae_AGAP003004-PA IKLSKQEIQLTKLNQE-------VDPRYSG-GVLLWKLDDFSNKIESMVANSN--CMFYSSEAYTSPHGYKFCARINVS----PRTKDSIGLHV-HLMQSENDYHLEWPFKGR---IKIT D_rerio_ENSDARP00000040549 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074051 RALHQTMQNISDLETQMAMQQRIASVQNIR-GHLIWRIKDYSKKLEESKQYDT---ILHSAMFSNKAFGYALRLDIYLNGKGTWK-GRNMIACL-NVLSGEYDPLLAWPCRLQ---AEII A_aegypti_AAEL015342-PA RETYYTKQSLDDLQVHLQHQEKLVVIQNTE-GHLIWRIDQFEKRFEESQQSEF---MLKSPLFSNRPFGYTLRMEASLNGIGTWR-GRNMIVGL-VVVNGFYDNLLEWPCVLS---GTIT A_aegypti_AAEL011363-PA RETYYTKQSLDDLQVHLQHQEKLVVIQNTE-GHLIWRIDQFEKRFEESQQSEF---MLKSPLFSNRQFGYTLRMEASLNGIGTWR-GRNMIVGL-VVVNGFYDNLLEWPCVLS---GTIT D_melanogaster_FBpp0071136 TRLENMQKQLRLARQQAP-----VDPRYSN-GTIVWRIEQLGALVARLRANAN--NQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHV-HLMQSENDYHLDWPFKGR---IKLC 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000247668 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ P_troglodytes_ENSPTRP00000036949 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ P_pygmaeus_ENSPPYP00000022191 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ M_mulatta_ENSMMUP00000015132 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VND--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ E_caballus_ENSECAP00000011150 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ C_familiaris_ENSCAFP00000028895 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ M_musculus_ENSMUSP00000109872 LLDHNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ B_taurus_ENSBTAP00000013869 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VGD--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ M_domestica_ENSMODP00000021625 LLDQNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASGCPLFCPVSKMES-KN-SYVRDDAIFIKAIVD-LTGL------------------------ G_gallus_ENSGALP00000014649 LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------VTE--MNIASGCPLFCPVSVMEA-KN-SYVRDDAIFIKAIVD-LSGL------------------------ R_norvegicus_ENSRNOP00000058607 LLDHNNR-------EHVIDAFRPDV---TSSS-FQRP------------VSD--MNIASGCPLFCPVSKIEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ G_gorilla_ENSGGOP00000006994 LLDQNNR-------EHVIDAFRPXV---TSSS-FQRP------------VND--MNIASGCPLFCPVSKMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ T_nigroviridis_ENSTNIP00000016461 LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASGCPLFCPLSKLDG-KN-SYIRDDTIFIKAIVD-LTGL------------------------ T_guttata_ENSTGUP00000002510 LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------VTE--MNIASGCPLFCPVSVMEA-KN-SYVRDDAIFIKAIVD-LTGL------------------------ G_aculeatus_ENSGACP00000006974 LLDQNSR-------EHIIDAFRPDV---SSSS-FQRP------------VSD--MNIASGCPLFCPLPKLDS-KN-SYIRDDTIFIKAIVD-LTGL------------------------ O_latipes_ENSORLP00000003220 LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASGCPLFCPLSKLDA-KN-SYIRDDTIFIKAIVD-LTGL------------------------ T_rubripes_ENSTRUP00000011363 LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASGCPLFCPLPKLDC-KN-SYIRDDTIFIKVIVD-LTGL------------------------ O_latipes_ENSORLP00000020860 LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASGCPLFCPLSKLDS-KN-SYIRDETIFIKAIVD-LSGL------------------------ T_rubripes_ENSTRUP00000015632 LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------VSE--MNIASGCPLFCPLSKLDG-KN-SYIRDDTIFIKAIVD-LTGL------------------------ T_nigroviridis_ENSTNIP00000013509 LLDQNNR-------EHIIDAFRPDV---SSSS-FQRP------------VSD--MNIASGCPLFCPLSKLDC-KN-SYIRDDTIFIKVIVD-LSGL------------------------ D_rerio_ENSDARP00000043465 LLDQNNR-------EHIIDAFRPDI---SSSS-FQRP------------VSD--MNIASGCPLFCPLSKLDS-KN-SYIRDDTIFIKAIVD-LTGL------------------------ D_rerio_ENSDARP00000069217 LLDQNNR-------EHIIDAFRPDV---SSTS-FQRP------------ISE--MNIASGCPLFCPLAKLAG-KS-SYLRDDTIFIKAIVD-LTGL------------------------ X_tropicalis_ENSXETP00000008559 LLDQNNR-------EHVIDAFRPDV---SSSS-FQRP------------ISE--MNIASGCPLFCQVSKLEG-KN-SYVRDDTIFVKVIVD-LTGL------------------------ G_aculeatus_ENSGACP00000020860 LLDQSNR-------EHIIDAFRPDV---TSSS-FQRP------------LER---------P--CSLC---------------------------F------------------------ T_nigroviridis_ENSTNIP00000011878 LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------ISE--MNIASGCPLFCPLAKLAG-KS-PYLKDDTIFIKAIVD-LTGL------------------------ T_rubripes_ENSTRUP00000047803 LLDQNNR-------EHIIDAFRPDV---TSSS-FQRP------------ISE--MNIASGCPLFCPLAKLAG-KS-PYLKDDTIFIKAIVD-LTGL------------------------ O_latipes_ENSORLP00000008989 AASKPNR------EEHIIDAFRPDI---TSTS-FQRP------------VSE--MNIASGCPLFCPLAKLAG-KS-PYLRDDTIFIKAIVD-LSGL------------------------ G_aculeatus_ENSGACP00000022084 LLDQNNR-------EHIIDAFRPDV---TSTS-FQRP------------ISE--MNIASGCPLFCPLAKLAG-KS-PYLRDDTIFIKAIVD-LTGL------------------------ A_carolinensis_ENSACAP00000006987 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002401 LLDQNNR-------EHIIDAFRPDL---ASAS-FQRP------------VND--MNVASGCPTFLPLTKLQSPKH-AYVKEDTLFLKCIID-LTAV------------------------ T_guttata_ENSTGUP00000006737 LLDQNNR-------EHIIDAFRPDL---TSAS-FQRP------------VND--MNVASGCPMFLPLAKLQSPKH-GYVREDTLFLKCIIE----------------------------- D_rerio_ENSDARP00000091948 LLDQNQR-------EHVIDAFRPDL---SSMS-FHQP------------VSD--MNVASGCPLFFPLKKLRSPKH-AYCKDDTIYIKCVVD-TSS------------------------- O_anatinus_ENSOANP00000001757 LLDQNNR-------EHVIDAFRPDL---NSAS-FQKP------------QGE--MNVASGCPMFFPLNKLQSPKH-AYVKDDTLFLKCIIE-TNS------------------------- T_rubripes_ENSTRUP00000013348 LMDQGPL------KKHLGDAFKPDP---NSSS-FRRP------------VVE--MNIASGCPLFVSQSVLETG---SYIKDDTIFIKVTVD-TSDL-----------------------P T_nigroviridis_ENSTNIP00000005138 LMDQGPL------KKHLGDAFKPDP---NSSS-FRRP------------VVE--MNIASGCPLFVSQSVLETG---SYIKDDTIFIKVTVD-TSDL-----------------------P G_aculeatus_ENSGACP00000005703 LMDQGPL------RKHLGDAFKPDP---NSSS-FRRP------------AAE--MNIASGCPLFVSQSVLETG---TYIKDDTIFIKVTVD-TSDL-----------------------P X_tropicalis_ENSXETP00000027864 LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P E_caballus_ENSECAP00000011833 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P D_rerio_ENSDARP00000038596 LMDQGPA------RKHLGDAFKPDP---SSSS-FRRP------------TGE--MNIASGCPLFVAQTVLENG---TYIKDDTIFIKVTVD-TSDL-----------------------P P_pygmaeus_ENSPPYP00000007003 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P P_troglodytes_ENSPTRP00000003288 LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E C_familiaris_ENSCAFP00000026713 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P A_carolinensis_ENSACAP00000000193 LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P P_troglodytes_ENSPTRP00000011503 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P M_mulatta_ENSMMUP00000038268 LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E M_musculus_ENSMUSP00000021706 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P P_pygmaeus_ENSPPYP00000000253 LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSVLENAKN-AYLKDDTLFLKVAVD-LTDL-----------------------E R_norvegicus_ENSRNOP00000010906 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P G_gallus_ENSGALP00000036699 LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P O_anatinus_ENSOANP00000023053 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P H_sapiens_ENSP00000376500 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P H_sapiens_ENSP00000336825 LLDQSGK------KN-IMETFKPDP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSVLENAKN-AYIKDDTLFLKVAVD-LTDL-----------------------E T_guttata_ENSTGUP00000013203 LMDQGPS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P B_taurus_ENSBTAP00000017918 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P M_domestica_ENSMODP00000024498 LLDQNNR-------EHVTDSFHPDL---TSGS-FQKP------------QGE--SNIASGRPMFFPLNKLQSSKH-AYVKDDTLFLKCVIE-TNS------------------------- O_anatinus_ENSOANP00000013484 LLDQSGK------KNHIVEIFKADP---NSSS-FKRP------------EGE--MNIASGCPCFVDHSKLENVKN-TFIKEDTLFMKVVVD-LTDL-----------------------E M_domestica_ENSMODP00000016701 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P E_caballus_ENSECAP00000005414 LLDQSGK------KNHIMETFKADP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSTLENAKN-TYIKDDTIFLKVAVD-LTDL-----------------------E T_guttata_ENSTGUP00000003276 LLDQSGK------KNHIVDVFRADP---NSSS-FKRP------------DGE--MNIASGCPRFVPHTVLESTKN-TYIRDDTLFLKVVVD-LTDL-----------------------E G_gallus_ENSGALP00000016021 LLDQTGK------KNHIVEVFRADP---NSSS-FKRP------------DGE--MNIASGCPRFVPHTVLENTKN-TYVRDDTLFLKVVVD-LTDL-----------------------E A_carolinensis_ENSACAP00000016112 LLDQSGK------KNHIVETFKADP---NSSS-FKRP------------EGE--MNVASGCPRFVPHTLLENAKS-TYIKDDTIFLKVVVD-LTDL-----------------------E B_taurus_ENSBTAP00000015940 LLDQSGK------KNHIMETFKADP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSTLENAKN-TYIKDDTLFLKVAVD-LTDL-----------------------E P_troglodytes_ENSPTRP00000036416 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFLPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- H_sapiens_ENSP00000362994 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- M_domestica_ENSMODP00000003305 LLDQSGK------KNHITEIFKADP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSTLESTKN-TYIKEDTLFMKVVVD-LSDL-----------------------E M_musculus_ENSMUSP00000082710 LLDQSGK------KNHIVETFKADP---NSSS-FKRP------------DGE--MNIASGCPRFVSHSTLENSKN-TYIKDDTLFLKVAVD-LTDL-----------------------E M_mulatta_ENSMMUP00000026496 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLNKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- M_musculus_ENSMUSP00000028234 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLSKLQSPKH-AYVKDDTMFLKCIVD-TSA------------------------- C_familiaris_ENSCAFP00000017853 LLDQSGK------KNHIMETFKADP---SSSS-FKRP------------DGE--MNIASGCPRFVAHSTLENAKN-TYIKDDTVFLKVAVD-LTDL-----------------------E O_cuniculus_ENSOCUP00000007884 LLDQSGK------RNHIMETFKADP---NSSS-FKRP------------DGE--MNIASGCPRFVAHSTLENAKN-TYIKEDTLFLKVAVD-LTDL-----------------------E P_pygmaeus_ENSPPYP00000021917 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- E_caballus_ENSECAP00000009372 LIDQNNR-------EHAIDAFRPDL---NSAS-FQRP------------QSE--TNVASGCPLFFPLSRLQSPKH-AYVKDDTMFLKCIVE-TSA------------------------- M_mulatta_ENSMMUP00000015419 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIK---------------------------------------- O_cuniculus_ENSOCUP00000004916 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLNKLQSPKH-AYVKDDTMFLKCIVE-TSA------------------------- B_taurus_ENSBTAP00000041215 LLDQNNR-------EHAIDAFRPDL---NSAS-FQRP------------QSE--TNVASGCPLFFPLNKLQSPKH-AYVKDDTMFVKCVVD-TNT------------------------- G_gorilla_ENSGGOP00000002249 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLSKLQSPKH-AYVKDDTMFLKCIVE-TST------------------------- X_tropicalis_ENSXETP00000031605 LLDQSGK------KNHITDVFRADP---NSSS-FKRP------------DSE--MNIASGCPRFASHAQLENPKNGCYIK---------------------------------------- C_intestinalis_ENSCINP00000001022 LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASGCPLFVAHNVIEGS---SYVKEDTIFLRIHVD-TSDL-----------------------E C_intestinalis_ENSCINP00000027890 LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASGCPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E C_intestinalis_ENSCINP00000001432 LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASGCPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E C_intestinalis_ENSCINP00000003143 LLDQGMD------RRHLSDTFRPDP---TSSS-FKKP------------TSD--MNIASGCPLFVAHNVIEDS---SYVKEDTIFLRIHVD-TSDL-----------------------E O_latipes_ENSORLP00000001368 VLDQSGA------RNHQSFNFRPDP---TNTC-FHQP------------AAESASNVAVGFPCFISLDALEAPGNAVYVKDDTLFVKVKVD-TTGL-----------------------E C_intestinalis_ENSCINP00000005981 LLDQGLE------RRHLSDMFRPDP---TSSS-FTKP------------TSD--MNIASGCPLFVAHNLIEGS---SYVKDDVIFIRIHVD-TTDL-----------------------E G_gorilla_ENSGGOP00000004192 LMDQGSS------RRHLGDAFKPDP---NSSS-FKKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P C_familiaris_ENSCAFP00000031262 LLDQNNR-------EHAIDAFRPDL---SSAS-FQRP------------QSE--TNVASGCPLFFPLSRLQSPKH-AYVKDDTMFLKCIVE-TNA------------------------- O_cuniculus_ENSOCUP00000003184 LMDQGSS------RRHLGDAFKPDP---NSSS-FRKP------------TGE--MNIASGCPVFVAQTVLENG---TYIKDDTIFIKVIVD-TSDL-----------------------P A_carolinensis_ENSACAP00000017068 LLDQDNK-------QHISTSFRPLE---SSSS-FQRP------------VNE--TNVASGLPEFCPLNVLHSPRT-SYICNDTLAIQAVID-M--------------------------- M_domestica_ENSMODP00000024090 LLDQSDP--AVAKPQHVTETFHPDP---HWKN-FQKP-----GTWRGS-MDE--SALGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPKKILS---------------------- D_rerio_ENSDARP00000013849 ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----CSSRNS-LDE--STLGFGYPKFISHEEIKKR---NYIRDNSIFLKASIEIPQKIMA---------------------- H_sapiens_ENSP00000262395 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- G_aculeatus_ENSGACP00000014759 ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----SSSRNS-LDE--STLGFGYPKFISHDEIKKR---NYIRDNCVFIKASIEIPQKIMT---------------------- B_taurus_ENSBTAP00000050075 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- M_musculus_ENSMUSP00000017530 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- R_norvegicus_ENSRNOP00000018468 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- G_gallus_ENSGALP00000012873 ILDQSEG----PERQNHEEVMEAKP---ELLA-FQRP------------TIHR-NPKGFGYVTFMHLQTLKQR---TFVKDDTLLVRCEVLTRLDL-----------------------N R_norvegicus_ENSRNOP00000006148 ILDQSEA----VIRQNHEEVMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQG---TFIKDDTLLVRCEVSTRFDM-----------------------G O_latipes_ENSORLP00000005579 ILDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----CSTRNS-LDE--STLGFGYPKFISHEEIKKR---NYIRDNCIFIKASIEIPQKIMG---------------------- D_rerio_ENSDARP00000014326 LLDQSGT------RNHMSHTFIPDV---NSDS-FHRP------------TSD--ANVATGFTRFISHCDLENPRNAVFVRDETLFIKVKV------------------------------ T_guttata_ENSTGUP00000010462 ILDQSEG----PERQNHEEVMEAKP---ELLA-FQRP------------TIHR-NPKGFGYVTFMHLETLKQR---TFIKDDTLLVRCEVLTRLDL-----------------------S T_rubripes_ENSTRUP00000012878 LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----SSTRNS-LDE--STLGFGYPKFISHEEIKKR---NYVRDNCIFIKASIEIPQKIMA---------------------- M_musculus_ENSMUSP00000004949 ILDQSEA----LIRQNHEEVMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQG---TFIKDDTLLVRCEVSTRFDM-----------------------G A_carolinensis_ENSACAP00000005007 VLDQSEG----SPRQNHEEVMDTKP---ELLA-FQRP------------KTRR-NPKGFGYVTFMQLQTLRQR---TYIKEDTVLVRCEVLTRLDV-----------------------M M_mulatta_ENSMMUP00000021907 ILDQSEA----PVRQNHEEIMDAKP---DLLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G O_anatinus_ENSOANP00000018657 ILDQSEA----PVRQNHEEIMDTKP---ELLA-FQRP------------TIHR-NPKGFGYVTFMHLQALRQR---AFIKDDTLLVRCEVSTRFDM-----------------------S P_pygmaeus_ENSPPYP00000003845 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G P_troglodytes_ENSPTRP00000006096 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G B_taurus_ENSBTAP00000021630 ILDQSEA----AVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G H_sapiens_ENSP00000316840 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G G_aculeatus_ENSGACP00000025883 LLDQSGA------ANHRSLSFRPDP---SSKS-FGRP------------AAESAGNVAVGFSCFLPLGELEPRHNAEYVKDDALFVKVKVD-TAGL-----------------------D M_domestica_ENSMODP00000024756 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLQALKQR---TFIKDDTLLVRCEVLTRLDM-----------------------N D_rerio_ENSDARP00000056877 LLDQCDP--ALTKPQHITETFSPDP---TWKN-FQRPRPGALGSIRGGCLDE--SMLGFGYPKFISHEEMKKR---NYIRDNAVFIKASIDVVQKILN---------------------- C_familiaris_ENSCAFP00000010159 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G G_aculeatus_ENSGACP00000022648 ILDQ--G----PEAQHHVEVMETKP---DLQA-FQKP------------LIQR-NPKGFGYVTFLHLHQLTQR---AFVKDDTLLIRCEVTPRFD------------------------N T_rubripes_ENSTRUP00000041697 ILDQ--G----PEGQHHVEVMETKP---DLQA-FQKP------------TIIR-NPKGFGYVTFLHLQQLNQR---AYVKDDILLIRCEVTPRFD------------------------N X_tropicalis_ENSXETP00000042386 LVDHNNR-------DSVFDAFRPDV---TSAS-FQRP------------IND--MNVASGCPLFCPIAKLNSPKH-AYIRENTLYIRCIIDTNS-------------------------- T_nigroviridis_ENSTNIP00000012472 ILDQ--G----PEGQHHIEVMETKP---DLQA-FQRP------------TIIR-NPKGFGYVTFLHLHHLKER---AYVKDDALLIRCEVTPRFD------------------------N M_mulatta_ENSMMUP00000028200 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- P_troglodytes_ENSPTRP00000015252 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- D_rerio_ENSDARP00000036715 VLDQ-------VEGQHHIEVMETKP---DLQA-FQRP------------TVMR-NPKGFGYVTFLHLQALRQR---GFVKEDVLLVRCEVTPRFD------------------------A E_caballus_ENSECAP00000009502 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- P_pygmaeus_ENSPPYP00000009119 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- X_tropicalis_ENSXETP00000016445 ILDQSEG----VAMQDQEEVMDTKP---ELLA-FQRP------------TVAR-NPKGFGYVTFMHLQALKQR---QYVKNDTLLVRCSVTTHLDL-----------------------I B_taurus_ENSBTAP00000016271 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- O_latipes_ENSORLP00000001290 ILDQ--G----PEGQHHMEVMETKP---DLQA-FQKP------------INQR-NPKGFGYVTFMHRSLLSQR---AYVKDDTLLIRCEV------------------------------ G_gorilla_ENSGGOP00000016344 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRAAVELPRKILS---------------------- X_tropicalis_ENSXETP00000056667 LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----TGSRNS-LDE--STLGFGYPKFISHEDIRKR---NYVRDNAIFLRASVEIPQKIIA---------------------- E_caballus_ENSECAP00000018618 ILDQSEA----PIRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G T_nigroviridis_ENSTNIP00000019321 LLDQSDP--SLSKPQHITETFNPDP---NWKN-FQKP-----NSTRNS-LDE--STLGFGYPKFISHEEIKKR---NYIRDNCIFIKASIEIPQKIMA---------------------- O_cuniculus_ENSOCUP00000000748 LLDQSDS--GWARPQHVTETFHADS---NWEEAFQKP-----GTWRGS-LDE--SSLGF------------------------------------------------------------- M_mulatta_ENSMMUP00000021905 ILDQSQA----PVRQNHEEIMDAKP---ELLA-FQQP------------TYP--NPKGFGYVTFIHLEALRQR---TFIKYDTLLVRCEVSTCFDM-----------------------G C_intestinalis_ENSCINP00000003738 LIDQSQD---PRARINHTYSLRPNPCKENKPF-LGRP------------TSE--SNPSFGSQTFMPLDTLNTR---DYIRDDAIFIRVSVLHDET------------------------- O_anatinus_ENSOANP00000028670 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000010330 ILDQSEA----PIRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G C_elegans_F45G2.6 LLDQNPRPEDRVNITYVIDPRKLKA---NEKF-LARP------------RGE--RNAAFGSQSFCSLAILQ-----NYVKDDKIYVQIDVDRCETLPVQLKSRDAKERKQMLDAMRAKTP D_melanogaster_FBpp0111838 LFEQGAQ----SGQGGVAESFVPDP---TWEN-FQRP------------SNEP-DQLGFGFPRFISHELLHSR---PFIKGDTVFLRVKVD-PSKIVAV--------------------- A_gambiae_AGAP010017-PA LFEQGTLGSGGGGQGGVAESFVPDP---TWEN-FQRP------------STEP-DALGFGFPRFVSHELLNRR---PFVRDDTVFLRVKVD-PSKIVAV--------------------- O_anatinus_ENSOANP00000019424 LLDQSDP--SLSKPQHVTETFHPDP---HWKN-FQKP-----GAWRGS-GSSG-AALGFGYPKFISHEDIRKR---DYVRDDAVFIRAAVELPRRILA---------------------- A_aegypti_AAEL006649-PA LFEQGTL----GSQGGVAESFVPDP---SWEN-FQRP------------STEP-DALGFGFPRFVSHELLNRR---PFVREDTVFLRVKVD-PSKIVAV--------------------- C_familiaris_ENSCAFP00000027741 LLDQSDP--GLAKPQHVTETFHPDP---NWKN-FQKP-----GTWRGS-LDE--SSLGFGYPKFISHQDIRKR---NYVRDDAVFIRASVELPRKILS---------------------- C_intestinalis_ENSCINP00000008928 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000012479 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000024257 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000005734 ILDQSEA----PVRQNHEEIMDAKP---ELLA-FQRP------------TIPR-NPKGFGYVTFMHLEALRQR---TFIKDDTLLVRCEVSTRFDM-----------------------G A_gambiae_AGAP003004-PA LLNVRSP------ELSQHDTIMSKP---EILA-FHRP------------NQDI-SPRGFGFLEFAKIKDILA----KFADNNTVVIKIQMNIV--------------------------- D_rerio_ENSDARP00000040549 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0074051 IRDQCTN------------VADAED---YVKTIFVRK------------KSD--DFIQSNQYFHIPHKVITSR---NYLRNDSMFIEVRVLK---------------------------- A_aegypti_AAEL015342-PA LRDQPQD--------------RAKPRVDYRRSIVARR------------KHQ--SN-DKNQNIHIPHQVLRSE---HYIRDDAIFLEVRIDQ---------------------------- A_aegypti_AAEL011363-PA LRDQPEV--------------RTKPRVDYRRSIVARR------------KHQ--SN-DKNQNIHIPHQVLRSE---HYIRDDAIFLEVRIDQ---------------------------- D_melanogaster_FBpp0071136 MVHPADA------TLSQHDTIMTKP---EILA-FHKP------------REAI-STRGFGFLEYANISNIIQL---GFCADDRLLIKIEINIV--------------------------- 970 980 =========+=========+= H_sapiens_ENSP00000247668 --------------------- P_troglodytes_ENSPTRP00000036949 --------------------- P_pygmaeus_ENSPPYP00000022191 --------------------- M_mulatta_ENSMMUP00000015132 --------------------- E_caballus_ENSECAP00000011150 --------------------- C_familiaris_ENSCAFP00000028895 --------------------- M_musculus_ENSMUSP00000109872 --------------------- B_taurus_ENSBTAP00000013869 --------------------- M_domestica_ENSMODP00000021625 --------------------- G_gallus_ENSGALP00000014649 --------------------- R_norvegicus_ENSRNOP00000058607 --------------------- G_gorilla_ENSGGOP00000006994 --------------------- T_nigroviridis_ENSTNIP00000016461 --------------------- T_guttata_ENSTGUP00000002510 --------------------- G_aculeatus_ENSGACP00000006974 --------------------- O_latipes_ENSORLP00000003220 --------------------- T_rubripes_ENSTRUP00000011363 --------------------- O_latipes_ENSORLP00000020860 --------------------- T_rubripes_ENSTRUP00000015632 --------------------- T_nigroviridis_ENSTNIP00000013509 --------------------- D_rerio_ENSDARP00000043465 --------------------- D_rerio_ENSDARP00000069217 --------------------- X_tropicalis_ENSXETP00000008559 --------------------- G_aculeatus_ENSGACP00000020860 --------------------- T_nigroviridis_ENSTNIP00000011878 --------------------- T_rubripes_ENSTRUP00000047803 --------------------- O_latipes_ENSORLP00000008989 --------------------- G_aculeatus_ENSGACP00000022084 --------------------- A_carolinensis_ENSACAP00000006987 --------------------- G_gallus_ENSGALP00000002401 --------------------- T_guttata_ENSTGUP00000006737 --------------------- D_rerio_ENSDARP00000091948 --------------------- O_anatinus_ENSOANP00000001757 --------------------- T_rubripes_ENSTRUP00000013348 EP------------------- T_nigroviridis_ENSTNIP00000005138 EP------------------- G_aculeatus_ENSGACP00000005703 DP------------------- X_tropicalis_ENSXETP00000027864 DP------------------- E_caballus_ENSECAP00000011833 DP------------------- D_rerio_ENSDARP00000038596 DP------------------- P_pygmaeus_ENSPPYP00000007003 DP------------------- P_troglodytes_ENSPTRP00000003288 DL------------------- C_familiaris_ENSCAFP00000026713 DP------------------- A_carolinensis_ENSACAP00000000193 DP------------------- P_troglodytes_ENSPTRP00000011503 DP------------------- M_mulatta_ENSMMUP00000038268 DL------------------- M_musculus_ENSMUSP00000021706 DP------------------- P_pygmaeus_ENSPPYP00000000253 DL------------------- R_norvegicus_ENSRNOP00000010906 DP------------------- G_gallus_ENSGALP00000036699 DP------------------- O_anatinus_ENSOANP00000023053 DP------------------- H_sapiens_ENSP00000376500 DP------------------- H_sapiens_ENSP00000336825 DL------------------- T_guttata_ENSTGUP00000013203 DP------------------- B_taurus_ENSBTAP00000017918 DP------------------- M_domestica_ENSMODP00000024498 --------------------- O_anatinus_ENSOANP00000013484 EL------------------- M_domestica_ENSMODP00000016701 DP------------------- E_caballus_ENSECAP00000005414 DL------------------- T_guttata_ENSTGUP00000003276 EL------------------- G_gallus_ENSGALP00000016021 EL------------------- A_carolinensis_ENSACAP00000016112 EL------------------- B_taurus_ENSBTAP00000015940 DL------------------- P_troglodytes_ENSPTRP00000036416 --------------------- H_sapiens_ENSP00000362994 --------------------- M_domestica_ENSMODP00000003305 DL------------------- M_musculus_ENSMUSP00000082710 DL------------------- M_mulatta_ENSMMUP00000026496 --------------------- M_musculus_ENSMUSP00000028234 --------------------- C_familiaris_ENSCAFP00000017853 DL------------------- O_cuniculus_ENSOCUP00000007884 DL------------------- P_pygmaeus_ENSPPYP00000021917 --------------------- E_caballus_ENSECAP00000009372 --------------------- M_mulatta_ENSMMUP00000015419 --------------------- O_cuniculus_ENSOCUP00000004916 --------------------- B_taurus_ENSBTAP00000041215 --------------------- G_gorilla_ENSGGOP00000002249 --------------------- X_tropicalis_ENSXETP00000031605 --------------------- C_intestinalis_ENSCINP00000001022 NF------------------- C_intestinalis_ENSCINP00000027890 NF------------------- C_intestinalis_ENSCINP00000001432 NF------------------- C_intestinalis_ENSCINP00000003143 NF------------------- O_latipes_ENSORLP00000001368 --------------------- C_intestinalis_ENSCINP00000005981 TF------------------- G_gorilla_ENSGGOP00000004192 DP------------------- C_familiaris_ENSCAFP00000031262 --------------------- O_cuniculus_ENSOCUP00000003184 DP------------------- A_carolinensis_ENSACAP00000017068 --------------------- M_domestica_ENSMODP00000024090 --------------------- D_rerio_ENSDARP00000013849 --------------------- H_sapiens_ENSP00000262395 --------------------- G_aculeatus_ENSGACP00000014759 --------------------- B_taurus_ENSBTAP00000050075 --------------------- M_musculus_ENSMUSP00000017530 --------------------- R_norvegicus_ENSRNOP00000018468 --------------------- G_gallus_ENSGALP00000012873 SLRREG--FQARSTDGAA--- R_norvegicus_ENSRNOP00000006148 GLRKEG--FQPRSTDAGV--- O_latipes_ENSORLP00000005579 --------------------- D_rerio_ENSDARP00000014326 --------------------- T_guttata_ENSTGUP00000010462 SVRREG--FQPRSTDGAM--- T_rubripes_ENSTRUP00000012878 --------------------- M_musculus_ENSMUSP00000004949 GLRKEG--FQPRSTDAGV--- A_carolinensis_ENSACAP00000005007 SPRREG--FQPRSTDGTV--- M_mulatta_ENSMMUP00000021907 SLRREG--FQPRSTDSGV--- O_anatinus_ENSOANP00000018657 SPRREG--FQPRSTDPGV--- P_pygmaeus_ENSPPYP00000003845 SLRREG--FQPRSTDAGV--- P_troglodytes_ENSPTRP00000006096 SLRREG--FQPRSTDAGV--- B_taurus_ENSBTAP00000021630 SLRREG--FQPRSTDSGI--- H_sapiens_ENSP00000316840 SLRREG--FQPRSTDAGV--- G_aculeatus_ENSGACP00000025883 PL------------------- M_domestica_ENSMODP00000024756 SLRREG--FQPRSTDAGV--- D_rerio_ENSDARP00000056877 --------------------- C_familiaris_ENSCAFP00000010159 SPRREG--FQPRSTDSGI--- G_aculeatus_ENSGACP00000022648 VLHRDGPTVQPRGPEASVSRD T_rubripes_ENSTRUP00000041697 MFHRDGITVQPRGPEASM--- X_tropicalis_ENSXETP00000042386 --------------------- T_nigroviridis_ENSTNIP00000012472 MLHRDGVTVQPRGSEASI--- M_mulatta_ENSMMUP00000028200 --------------------- P_troglodytes_ENSPTRP00000015252 --------------------- D_rerio_ENSDARP00000036715 SLRREG--VQPRGPEPSI--- E_caballus_ENSECAP00000009502 --------------------- P_pygmaeus_ENSPPYP00000009119 --------------------- X_tropicalis_ENSXETP00000016445 SPRREG--FQPRSGDGAL--- B_taurus_ENSBTAP00000016271 --------------------- O_latipes_ENSORLP00000001290 --------------------- G_gorilla_ENSGGOP00000016344 --------------------- X_tropicalis_ENSXETP00000056667 --------------------- E_caballus_ENSECAP00000018618 SLRREG--FQPRSTDTGV--- T_nigroviridis_ENSTNIP00000019321 --------------------- O_cuniculus_ENSOCUP00000000748 --------------------- M_mulatta_ENSMMUP00000021905 SLRREG--FQPQSTDAGI--- C_intestinalis_ENSCINP00000003738 --------------------- O_anatinus_ENSOANP00000028670 --------------------- O_cuniculus_ENSOCUP00000010330 SLRREG--FQPRSTDAGV--- C_elegans_F45G2.6 DVRLHQVRPVTSQSSSAELRV D_melanogaster_FBpp0111838 --------------------- A_gambiae_AGAP010017-PA --------------------- O_anatinus_ENSOANP00000019424 --------------------- A_aegypti_AAEL006649-PA --------------------- C_familiaris_ENSCAFP00000027741 --------------------- C_intestinalis_ENSCINP00000008928 --------------------- G_gorilla_ENSGGOP00000012479 --------------------- O_latipes_ENSORLP00000024257 --------------------- G_gorilla_ENSGGOP00000005734 SLRREG--FQPRSTDAGV--- A_gambiae_AGAP003004-PA --------------------- D_rerio_ENSDARP00000040549 --------------------- D_melanogaster_FBpp0074051 --------------------- A_aegypti_AAEL015342-PA --------------------- A_aegypti_AAEL011363-PA --------------------- D_melanogaster_FBpp0071136 ---------------------