>H_sapiens_ENSP00000247470 MG--------------RARDAILDALENLTAEEL--KKFKLKLLSVP-LREGYGRIPRGA LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---TDKLVSFYLETYGAELTANV-------LRDM GLQEMAGQLQ--AATHQGSGAAPA-GIQA-----------------PPQSAAKP-GLHFI DQHRAALIARVTNVEWLL---DA-LYGK--------------VLTDEQYQAVRAEPTNPS KMRKL-FS-FTPAWNWTCKDLLLQALRESQSYLVEDLERS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >G_gorilla_ENSGGOP00000016734 MG--------------RARDAILDALENLTAEEL--KKFKLKLLSVP-LREGYGRIPRGA LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---TDKLVSFYLETYGAELTANV-------LRDM GLQEMAGQLQ--AATHQGSGAAPA-GIQA-----------------PPQSAAKP-GLHFI DQHRAALIARVTNVEWLL---DA-LYGK--------------VLTDEQYQAVRAEPTNPS KMRKL-FS-FTPAWNWTCKDLLLQALRESQSYLVEDLERS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >P_troglodytes_ENSPTRP00000013732 MG--------------RARDAILDALENLTAEEL--KKFKLKLLSVP-LREGYGRIPRGA LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---TDKLVSFYLETYGAELTANV-------LRDM GLQEMAGQLQ--AATHQGSGAEPA-GIQA-----------------PPQSAAKP-GLHFI DQHRAALIARVTNVEWLL---DA-LYGK--------------VLTDEQYQAVRAEPTNPS KMRKL-FS-FTPAWNWTCKDLLLQALRESQSYLVEDLEQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >P_pygmaeus_ENSPPYP00000008260 MG--------------RARDAILDALENLTAEEL--KKFKLKLLSVP-LREGYGRIPRGA LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---TDKLVSFYLEAYGAELTANV-------LRDM GLQEMAGQLQ--AATHQGCGAAPA-GIQA-----------------PPQSAAKP-GLHFI DQHRAALIARVTNVEWLL---DA-LYGK--------------VLTDEQYQAVRAEPTNPS KMRKL-FS-FTPAWNWTCKDLLLQALRESQSYLLEDLERS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_mulatta_ENSMMUP00000028578 MG--------------RARDAILDALENLTAEEL--KKFKLKLLSVP-LREGYGRIPRGA LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---TDKLVSFYLEAYGAELTANV-------LRDM GLHETAGQLQ--AATHQGSGAAPA-GIQA-----------------PPRSAAKP-GLHFV DQHRAALIARVTDVEGLL---DA-LYGT--------------VLKDQQYQEVQAESTNPS KMRKL-FS-FMPAWNWTCKDLFLQALRETQSYLVEDLERS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >O_cuniculus_ENSOCUP00000003881 MG--------------RARDAILEALENLTADEF--KKFKHKLLSVP-LREGYGRIPRGT LLS-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AVDL---TDKLVSFYLETYGAELTAAV-------LRDM GMQESAEQLE--ELLSQGSGAAPAAGIKA-----------------HSEKIAKP-ALHFV DQHRAALISRVTDVDGVL---DV-LHGR--------------VLTEEQYQAVRAETTNPN KMRKL-FS-FAPAWDLTCKDLLLQALRDTQPYLVADLEPR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >C_familiaris_ENSCAFP00000024803 MG--------------RIRDAILDALENLTAEEF--KKFKMKLLSVP-LREGYGRIPRGT LLP-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AMDL---TDKLVSFYLEEYGAELTAVV-------LRDI GMQETAERLQ--ETSHKGHTPGPA-GIQ------------------DYQTAAKPGASHFV DQHRAALITRVTEVDEVL---DA-LYGK--------------VLSEQQYQAVRAESTNPG KMRKL-FS-FAPAWNTTCKDLLLTALRNTQPYLVADLEKS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >E_caballus_ENSECAP00000008035 MG--------------RTRDAILEALENLTADEL--KKFKMKLLSVP-LREGYGRIPRGT LLT-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AMDL---TDKLVSFYLEAYGAELTELV-------LRDM GMQETAERLQ--EITRKEPGATPA--LKA-----------------PPQMAAKI-ALHFM DQHRAALIARVTEVDGVL---DA-LYGR--------------VLTEEQYQAVRAETTNPA KMRKL-FS-FAPAWNLTCKDLLLHALKETQPYLVADLEQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >B_taurus_ENSBTAP00000027359 MG--------------CTRDAILDALENLTADEF--KKFKMKLLSVP-LREGYGRIPRGT LLP-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AVDL---TDKLVSYYLEAYGAELTALV-------LRDM GMQEVAEQLQ--ETMSKGPRNVLA-EVRD-----------------PLQKTAKP-GLHFV DQHRAALIARVTVVDGVL---DA-LYGK--------------VLTEEQYQAVRAERTSSD KMRKL-FS-FSPAWNMTCKDLLLQALRDTQPYLVDDLEQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >R_norvegicus_ENSRNOP00000026699 MG--------------RARDAILDALENLTADEF--KKFKMKLLTAP-VREGYGRIPRGA LLQ-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PIDL---TDKLVSYYLEGYGLELTMTV-------LRDM GIQELAEQLQ--KIMEESGAVATATSV-------------------PAQGTART--EHFV DQHRQALIARVTEVDGLL---DA-LYGN--------------VLTEGQYQAVRAETTNQN KMRKL-FS-FAPAWNLTCKNLFLEALRQTQPYLVTDLEQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_musculus_ENSMUSP00000033056 MG--------------RARDAILDALENLSGDEL--KKFKMKLLTVQ-LREGYGRIPRGA LLQ-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AIDL---TDKLVSYYLESYGLELTMTV-------LRDM GLQELAEQLQ--TTKEESGAVAAAASV-------------------PAQSTART--GHFV DQHRQALIARVTEVDGVL---DA-LHGS--------------VLTEGQYQAVRAETTSQD KMRKL-FS-FVPSWNLTCKDSLLQALKEIHPYLVMDLEQS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >O_anatinus_ENSOANP00000002200 MG--------------SARDHILTALENLTSDEF--KKFKTKLLSCP-LREGFGRIPRGP LMN-MD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VIDL---TDKIVTTYMENYGLELTTAI-------LRDI NQAEAAALQK--ATGADLPCLSLFLTAAPRV---------------GPSKIALE-QQHFM DKHRQALINRVTSVDALL---DA-LYGK--------------VLSEQQYQEVRAEKPSAN QMRKL-FS-FSVAWNRSCKDQLFQALKATHPFLVSDLENS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_domestica_ENSMODP00000037463 MT--------------RARDLILRALEDLENDDF--KKFKLKLRTLK-LREGFNAIPRGI LEN-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RVDL---TDKIVCCYLEDYGLVLTAEV-------LQEI GMREEANWLL--SWGHRFMPSIPSYPHRLAPS--------------PPSLPLPK-GIHFV EKHRTSLINRVTSVDAIL---DR-LHGS--------------VLSQEQYDAVRAENTHQN KMRKL-LG-FMVAWDKSCKDQLLEALRDLHPYLVQELERN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >A_carolinensis_ENSACAP00000006535 K---------------STQDRLLDALENLEETDL--KRFKRKLNEFP-VKKGYENIPKGR LEK-AD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ALDL---AELLLSFYAEEYAEEVAIGV-------LEEI NCKRQAEKLA--SLAGTSKEDITSGAV-------------------VLNLWVAR-WVHFI DRHREELIQR-TPIDQVL---DC-LYGT--------------VLTPEQYEKIRAKETNQE KMRELYYK-IMPSWNNYCKDQLYVALKDKNPYLIEDLEGK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >B_taurus_ENSBTAP00000027232 MA-------------GEA--RSLEDLEEKKKQKL--KELRLWLPDEE-PRLQSPEVVHAQ PEK-PRSRKTMT-ILSVMKEVQHECMAIHTKGPHVNEQGACTKTLEETDLNSALYSSFSH SPSAPNLESPSWPTSTKVLTFCKPKQP---VLNPLKWSSSP-----LIFASGYRKEDLSP SI-YQ-GFPSSPYHE-SPSQELPNDPTSTAVLRACEIPRHSCPEPREKEGPGTVWPLVET SGNSCTEVDTVENINSQNGRDGIQPPLSLMPLLPPSTHLMFCFPCHRSRQRYQDQRRETP CS--TWSWKNEDLHPKFMQLL-------LLHTPYHKDYESLN---RESWDHGVVEGQGHL IEVRDLFGSDLGSQEGPHTVILHGVAGIGKSTLARHIRRAWEEGQLYRNHFQHVFYFNCR ELATSKLTS--LEELITKDQSTTVAPAGQIQSQPEQLLFILDGLDELECVSEEKRAELCL HRSQQQSVQTLLGSLVEKTIFPEASLLITARTAALQKFIPSLKQPCWVEVLGFSESSRKD YFYEYFTEESQATRAFS------------------------------------------- ---------------------------------------------VVESNQALLTMCLTP LVSWLACTCLKQQMEAGEELSL-KSQTMTALYLRYLAQAIQA--------QPLGTQLRGF CTLAAEGIC-QGKTLFSPGDLKKHGLDGVISATPL--KMDVLQKHPTSLNYSFIHLCFQE FFAAVSFALGDIRDKSDHPNS--TGSMEKLVEVYGINNLFGAPTVHFLSGLLSEQGAREM ENIFQCKLSWERKRESLLRWA-------------------------------ELELRREH YSLQLFHCLYEIQDEEFLTQAMAHFQGM------------------RVCIRTSMELLVFT FCIRFCSHVWRLQLN------EGRQHPGACRPTDTVLLSWVPATEACWQVLCSVLQVTGN LKELDLSRNILSRSAVQSLDEALRCPGCQLETLRLASCSLTAESCKDIASGLSTSQTL-M QLELSFNTLLDAGAEHLCQGLRQPTCKLQRLLLAGCGLTSGCCQDLASMLRVSPSLMELN LLQNDLDDLGVRLLCEGLRHPSCQLICLWLDQTQLSEEVTKMLRALERQKPQLLVSGIWK PSLRILHEGPGGAEMSD-TSSLKRQRQASARQKN---------LKL-A----AALS---A PEGSSPQAAQVRLFCPSSPAPPEDEHMESLGTEDDLWGPTGPVATEAVDEERSLYRVHLP MAGFYHWPNTGLRFEVRGPVTVEIEFCAWDQFLNRNFPQRSWLAAGPLFDIKAEPGAVAA VFLPHFVAFRGNDVDISQFQVAHFKEEGMLLEKPARVTPCYAVLENPSFSPMGVLLRMVQ TALRFIPITSTVLLYHYLQPEEVTFHLYLIPSDCSIQKAIDNEEKMFQFVRIHKPPPLTP LYMGSRYIVSGSEK--LEILPEELELCYRSPRESQLFSEFYVRHLRSGI-------RLQI RSKKDGTVVW--EALVKPG--DLRRAVTPVSP--------GLRAS-PDSPAALR-LRHFV DRHREQLVARVTSVDPIL---DK-LHGQ--------------VLSEEQYEGVRAETTAPG QMRRL-FG-FSRSWDWACKDRLYQALKETHPHLIMELWEKWGSEETRPG-S--------- ------------------------------------------------------------ ------------------------------------------------------------ -- >E_caballus_ENSECAP00000006832 MA-------------GGAELQWPWYLESREKKEP--KEFQLRLPD-A-HSRHSPGETVAQ VE--ASGPEVASRLVALYGQRQAWDLALLTQR---RMDLSRVSIQAHREAASIPISSLHA SLGKPNLEFSSAPTSTMVLGHWVPEAP-GLLQDSQRKNLRH-----LPGTSGHTWKENPP SFPFQ-DFPYSPVCE-SPSQESPNAPTSTAVLGGWEFPPQSMLACRKQEPPRTAWPLAET SGKHSTVVEGRDRRGHLTGV----PLMAAEPGSEPQAHTEH----PGLWERYQKQWRETP CP--TQSRQNEDLHQKFVQLL-------LLHTSDPGSHESLV---RRCCPHGVVEEEGHL IEIGDLFGPGLGTQRGPHTVVLHGVTGIGKSTLARQVRGAWEEGRLYRDRFQHVFYFNCT ELAQSKPVS--LAKLMGEDCAAPAPPIR---SQQEKMLFILDGLDEPELVLEE-QRPLCE DWSLRQPVPRVLHSLLRKVLLPEASLLVTARTPAPQKFILSLEHPHWVEVLGFSESSRKE YFYRYFTEESQAVQAFS------------------------------------------- ---------------------------------------------LVESNPALLTLCLVP FVSWMVCTCLKQQMERGEELSL-TSQTTTALCLHYLSQALPA--------QPLRTQLRCL CSLAAEGVG-QGETLFSLNDLRKHRLDGACISTLL--KMGLLQKHPTSQRYSFIHPFFQG FFAAMSYALGDKE-KSDHLNS--TRRIKKLLEKCERHDPFGTPTTPFLFGLLSEQGVRKM EHIFRCKLSQERKGD-LLQKV------------------------------RRGHPSLPP YSLQVLRCLYEIQDEDFLTQAMAHFQRT------------------RMYVQTDMELLVFT FCVKFCHHVERLQLN------ESGPHRQAWRPSSVVLLSRAPVTDACWKVLFSVLQVTGS LKELDLSGNFLSLSAVQSLCEALRHPRCHLQTLRLASCGLTAEGCKDLASGLSTSQTL-T ELELSCNVLEDAGVKHLCQGLRQPSCVLQRLLLVSCGLTSGFCQDLASVLSAGSRLTELD LQQNKLGDLGVKLLCEGLRRPTCQLMLLWLDQTQLNEEVTEMLRALEK-NAQLLILSRWK PSVTTPNEGRDGGEMSENRCSLKRQRAESARAQSPKAHSGLLSLEL-T----TALP---V PESSSPQVVQVQPLFLPFPASPGDPHVEPLETKDDFWGPMGPVATEVVDKERSLYRVHLP MAGSYRWPNTGLHFVVRGPVTIEIEFCAWGQFLDRTVPQHSWMVVGPLFDIKAEPGAVAA VYLPHFVVLQGAHVDISLFQVAHFKEEGMLLEKPARVEPCYAVLENPSFSPVGVLLRMIH AALPFIPVTSTVLLYYHFQPEEVTFHLYLIPNDCTIRKAIDDEEKKFQFVRIHKPPPLTP LYVGSRYTVSGSKK--LEIIPKELELCYRSPGESQLFSEFYIDHFGTGI-------KLQM RDKKDGTVVW--EALVKRG--KVETKAVVKPS--------CLLAVSPSHGLAPA-SLHFV DRYREQLVARVTSVDPVL---DK-LHGL--------------VLSEEQYEKVRAEATTPS QMRKL-FS-FSKSWDWACKDKFYQALKETHPHLIVELWEK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >H_sapiens_ENSP00000304336 MG--------------TKREAILKVLENLTPEEL--KKFKMKLGTVP-LREGFERIPRGA LGQ-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IVDL---TDKLVASYYEDYAAELVVAV-------LRDM RMLEEAARLQ--RAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >P_troglodytes_ENSPTRP00000013736 MG--------------TKREAILKVLENLTPEEL--KKFKMKLGTVP-LREGFERIPRGA LGQ-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IVDL---TDKLVASYYEDYAAELVVAV-------LRDM RMLEEAARLQ--RAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >M_musculus_ENSMUSP00000104155 ME------------------------ESQYKQE--------------------------- ----------HNKKVAQDEGQEDKDTIFETIE---------------------------- ------------------------------AIEAKLMELKT---------------NPES TFNYG-IFP--------------------------------------------------- -------------------------------------------------EVYMNQGEEIL YP--AWSLKEENLFQTFKSLR-------LFQKLCPRGSGNLV---KKSWYPCVPEEGGHI INIQDLFGPNIGTQKEPQLVIIEGAAGIGKSTLARQVKRAWMEGELYRDHFQHVFFFSCR ELAQCKKLS--LAELITQGQDVPTAPINQILSHPEKLLFILDGIDEPAWVLADQNPELCL YWSQTQPVHTLLGSLLGKSILPEASFLLTTRTTALQKFIPSLPQSCQVEVLGFSDFEQEI YIYKYFAKQIFGIKALM------------------------------------------- ---------------------------------------------MVESNPVLLTLCEVP WVCWLVCNCLKKQMEQGGDVSL-TSQTTTAICLKYISLTIPV--------HHMRTQLRAL CSLAAEGIW-KRRTLFSESDLCKQGLDEDAVAIFL--KTGVLQKQASSLSYSFAHLCLQE FFASMSCILEDSEERHGDMEM--DRIVETLVERYGRQNLFEAPTVRFLFGLLSKEGLKEM EKLFSCSLPGKTKLK-LLWHI-----------------------------LGKSQPHQPP C-LGLLHCLYENQDMKLLTHVMHDLQGTIVPDTDDITHTVLQTNVKHLVVRTDMELMVVT FCIQFCSHMRSLQLN------MEGQQGYALTAPRMVLYRWTPITNASWKILFYNLKFNSN LEGLDLSGNPLSYSAVQYLCDAMIYPGCQLKTL--------------------------- -------------------------------WLVECGLTPTYCSLLASVLSACSSLRELD LQLNDLCDDGVRMLCEGLRNRACNLRILRLDLYSLSAQVITELRTLEENNLKLHISSIWM PQMMVPTENMDEEDILTS---FKQQRQQSGA----------------------------- ------------------------NPMEILGTEEDFWGPIGPVATEVVYRERNLYRVQLP MAGSYHCPSTRLHFVVTRAVTIEIEFCAWSQFLDKTPLQQSHMVVGPLFDIKAEQGAVTA VYLPHFVSLKDTKASTFDFKVAHFQEHGMVLETPDRVKPGYTVLKNPSFSPMGVVLRIIP AARHFIPITSITLIYYRVNQEEVTLHLYLVPNDCTIQKAIDDEEMKFQFVRINKPPPVDN LFIGSRYIVSGSEN--LEITPKELELCYRSSKEFQLFSEIYVGNMGSEI-------KLQI KNKKHMKLIW--EALLKPG--DLRPALPRIAQALK---------------DAPS-LLHFM DQHREQLVARVTSVDPLL---DK-LHGL--------------VLNEESYEAVRAENTNQD KMRKL-FN-LSRSWSRACKDLFYQALKETHPHLVMDLLEKSGGVSLGS------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >G_gorilla_ENSGGOP00000011186 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ISA SLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDET SGIYYTEIRERERXKSEKGR----PPWAAVVGTPPQAHASL----QPHHHPWEPSVRESL CS--TWPWKNEDLNQKFTQLL-------LLQRPHPRSQDPLV---KRSWPDYVEENRGHL IEIRDLFGPVLDTQE-PRVVILQGAAGTGKSTLAMQVKEAWGRGQLYGDRFQHVFYFSCR ELAQSKVVS--LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCL HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE YFYKYFTDERQAIRAFR------------------------------------------- ---------------------------------------------LVKSNKELWALCLVP WVSWLACTCLMQQMKRKEKLTL-TSKTTTTLCLHYLSQALQA--------QPLGPQLRDL CSLAAEGIW-QKKTLFSPDDLRKHGLDGAIISTLL--KMGILQEHPIPLSYSFIHLCFQE FFAAMSYVLEDKKGRGKHSNC--IIDLEKMLEAYGIHGLFGASTTRFLLGLLSDEGEREM ENIFHCQLSQGR--N-LMQWV------------------------------PSLQLLLQP HSLESLHCLYETRNKTFLTKVMAHFXEM------------------GMCVETDMELLVCT FCIKFSRHVKKLQLI------EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRN LKELDLSGNSLSHSAVKSLCKTLRRPRCLLEILRLAGCGLIAQDCKDLAFGLRANQTL-T ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELX LQQNNLDDVGVRLLCEGLRHPACKLIRLGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRAASHVAQANLKLLDV-S----KIFPIAEI AEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGXXXXXXXXXXXXXXXXXXVHFP VAGSYRWPNTGLCFVVREAVTVEIELCVWDQFLGEINPRHSWMVAGPLLDIKAEPGAVEA VHLPHFVALQGGHVDTSLFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIH NALRFIPVTSVVLLYHRLHPEEVTFHLYLIPSDCSIRKXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXELELCYRSPGEDQLFSEFYVGHLGSGI-------RLQV KDKRDETLVW--EALVKPG--DLMPATTLVPP--------ARIAV-PSPLDAPR-LLHFV DQYREQLIARVTSVEVVL---DK-LHGQ--------------VLSQEQYERVLAENTRPS QMRKL-FS-LSQSWDRKCKDRLYQALKETHPHLIMELWEKGSKKGLLPL-SS-------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_musculus_ENSMUSP00000038186 ME------------------------ESQSKQE--------------------------- ----------SSTKVAQHEGQEDVDPTFKTKK---------------------------- ------------------------------LMEVELMKHRV---------------QLER NLKLR-TFP--------------------------------------------------- -------------------------------------------------GARTKQVKEAL YPLLTWSSKSKNLFQNFTKLL-------LFKKLCQRGSENLV---RESWYPCVPEEEAHM IDIQDLFGPNLGTQKKPQLVIIEGAAGIGKSTLARLVKRAWKEGKLYRNDFHHVFFFSCR ELAQYEQLS--LAELIVQGQEVPTAPIRQILSHPEKLLFILDGIDEPAWVLADQNPELCL HWSQTQPVHTLLGSLLGKSILPGASFLLTTRTTALQKFIPSLEQPCQVEVLGFTLFERKN YFYKYFGKKKGGVTTFT------------------------------------------- ---------------------------------------------LVKSNSALLTLCEVP WVCWLVCTCLKKQMEQGGELSL-TSQTTTALCLKYLSLTIPG--------QHMRTQLRDL CSLAAEGVC-QRRTLFSESDLCKQGLDEHAIASFL--KIGVLQKQASSLSYSFAHLCLQE FFAAMSYILDDSEERHADMKN--DRIVETLVERYGRQNLFEAPTVRFLFGLLSKEELKKI EKLFSCSLHGKTKLK-LLWHI-----------------------------LGKSQPHQPP C-LGLLHCLYENQDMELLTHVMHDLQGTIVPGPDDLAHTVLQTNVKHLVIQTDMDLMVVT FCIKFCCHVRSLQLN------RKVQQGHKFTAPGMVLYRWTPITDASWKIFFSNLKLARN LEELDLSGNPLSYYAVHSLCTTLRKRGCQLKTL----CTLPEDMNKAEVKNTEAKGSL-G EKAPGPRNDIFPFPPAHCPYNQTSTSEHLPCRLVECGLTSTYCSLLASVLSARSSLTELD LQLNDLGDGGVKMLCEGLRNPACNLSILWLDQASLSDQVIAELRTLEAKNPKLLISSTWK PHVMVPTMNMDKEEVGDSQALLKQQRQQSGMVGWLLKEDNVKKIKQ-N----ATNTYAHT HTHTHAELVPLKTFHPCSPVSPGDKHMEPLGTEDEFWGPTGPVTTEVVDRERNLYRVQLP MAGSYHCPSTGLHFVVTRAVTIEIEFCAWSQYLDKTPLQQSHMVVGPLFDIKAEQGAVTA VYLPHFVALQEGIVDSSLFHVAHFQEHGMVLETPARVEQHYAVLENPSFSPMGILLRMIP AVGHFIPITSTTLIYYHLYLEDVTFHLYLVPNDCSIRKAIDDEEMKFQFVRINKPPPVDA LYLGSRYIVSSSKL--VEIIPKELELCYRSPGESQLFSEIDIGHMDSEI-------KLQI KDKRHMNLKW--EALLKPGKISLRPETLRVEERDTKGAFLCSFPVSSLSLDAPS-LLHFM DQHREQLVARVTSVDPLL---DK-LHGL--------------VLSEDSYEVVRSETTNQD KMRKL-FS-LSRSWSWDCKDQFYQALKETHPHLVMDILEKLGGVSVKS------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >R_norvegicus_ENSRNOP00000034130 ME------------------------ESQSKQE--------------------------- ----------SNTRVAQHGSQQDVDPTFQTKR---------------------------- ------------------------------ALEKERSKPRP---------------RPLP RVQLQ-SLP--------------------------------------------------- -------------------------------------------------GWKGSQIKNAV SGLQWWSMEQKYLFQNFTKLL-------LLQKCCPGGSEKLV---RESWHPCVPEEGGHM IEIQDLFDPNLDTEKKPQLVIIEGAAGIGKSTLARQVKRAWDEGQLYRDRFQHVFFFSCR ELAQCKQLS--LAELIAQGQEVPTAPTRQILSRPEKLLFILDGIDEPAWVLEDQNPELCV HWSQAQPVHTLLGSLLGKSILPEASLMLTARTTALQKLVPSLGQPHRVEVLGFSEFERKD YFYKYFAKERNTIIDFN------------------------------------------- ---------------------------------------------LIGSIPVLLTLCEVP WVCWLLCTCLEKQMQQGEVLSL-TSQTTTALCLKYLSLTIPG--------QHLSTQLRTL CSLAAEGIC-QRRTLFSKSDLCKQGLAEDAIATFL--KIGVLQRQPSSLSYSFAHLCLQE FFAAMSYILEDSEEAHGDMGN--DRTVETLVERYGRQNLFEAPTVRFLLGLLNTREMREM ENIFACKFPWETKLK-LLQSI-----------------------------IG--EPFCQP CHLGLFHCLYENQEEELLTETMLCFPLT-ASGPNHMEATVFQTNVKRLVIQTDMELMVVT FCITF-SHVRSLRLK------GKGQQEYKLTAPAMVLYRWTPISEASWKVLFSNLKCTRN LEELDLSGNPLSYSAVRSLCTALRQPGCRLKTL----CTYPEDMAKTEVKNT-GKGSLRG ESSRGPR-EVLPWPMAAKHWPGETDGEHLPFRLVDCGLTSRCCSFLASMLSAHSRLAELD LRLNDLGDNGVRQLCEGLRNPACNLSILRLDQASLSEQVITELRALETKNPKLFISSTWM SHMTMPTENTDGEESLTS---SKQQQQQSGMLGWLIK-SNVKKIKQ-N----LPLSLSLS LSLSLSLSLSL-TFHPCSPVSPGDKHMEPLGTDDDFWGPSGPVSTEVVDRERNLYRVRLP MAGSYHCPSTGLHFVVTRAVTIEIGFCAWSQFLHETPLQHSHMVAGPLFDIKAEHGAVTA VCLPHFVSLQEGKVDSSLFHVAHFQDHGMVLETPARVEPHFAVLENPSFSPMGVLLRMIP AVGHFIPITSITLIYYRLYLEDITFHLYLVPNDCTIRKAIDEEELKFQFVRINKPPPVDA LYVGSRYIVSSSKE--VEILPKELELCYRSPRESQLFSEIYVGNIGSGI-------NLQL TDKKYMNLIW--EALLKPGKISLRPETLRPQERDPKGAFLCSEPV-SLPLDAPA-LLHFV DQHREQLVARVTSVDPLL---DK-LHGL--------------VLSEEDYETVRAEATNQD KMRKL-FR-GSRSWSWDCKDHFYQALKETHPHLIMDLLEKSGGVSVRL------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >P_troglodytes_ENSPTRP00000014740 MA-------------GGAWGRLACYLEFLKKEEL--KEFQLLLANKA-HSRSSSGETPAQ PEK-TSGMEVASYLVAQYGEQRAWDLALHTWE---QMGLRSLCTQAQEGAGHSP--SFPY SPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ-----LPDTSGRRWREISA SLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDET SGIYYTEIREREREKSEKGR----PPWAAVVGTPPQAHASL----QPHHHPWEPSVRESL CS--TWPWKNEDLNQKFTQLL-------LLQRPHPRSQDPLV---KRSWPDYVEENRGHL IEIRDLFGPGLDTQE-PRVVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR ELAQSKVVS--LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCL HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE YFYKYFTDERQAIRAFR------------------------------------------- ---------------------------------------------LVKSNKELWALCLVP WVSWLACTCLMQQMKQKEKLTL-TSKTTTTLCLHYLAQALQA--------QPLGPQLRDL CSLAAEGIW-QKKTLFSPDDLRKHGLDGAIISTLL--KMGILQEHPIPLSYSFIHLCFQE FFAAMSYVLEDKKGRGKHSNC--IIDLEKMLEAYGIHGLFGASTTRFLLGLLSDEGEREM ENIFHCRLSQGR--N-LMQWV------------------------------PSLQLLLQP HSLESLHCLYETRNKTFLTQVMAHFEEM------------------GMCVETDMELLVCT FCIKFSHHVKKLQLI------EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRN LKELDLSGNLLSHSAVKSLCKTLRRPRCLLETLRLAGCGLRAEDCKDLAFGLRANQAL-T ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD LQQNNLDDVGVRLLCEGLRHPACKLIHLGLDQMTLSDEMRQELRALEQEKPQLLIFSR-- ------------------------------RAASHVAQANLKLLDV-S----KIFPIAEI AEESSPEVVPVELLCVPSPASQGDLHMKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFP VAGSYRWPNTGLCFVVREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEA VHLPHFVALQGGHVDTSLFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIH NALRFIPVTSVVLLYHRLHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTP LYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGI-------RLQV KDKKDETLVW--EALVKPG--DLMPATTLVPP--------ARLAV-PSPLDAPQ-LLHFV DQYREQLIARVTSVEVVL---DK-LHGQ--------------VLSQEQYERVLAENTRPS QMRKL-FS-LSQSWDRKCKDRLYQALKETHPHLIMELWEKGSKKGLLPL-SS-------- ------------------------------------------------------------ ------------------------------------------------------------ -- >H_sapiens_ENSP00000269280 MA-------------GGAWGRLACYLEFLKKEEL--KEFQLLLANKA-HSRSSSGETPAQ PEK-TSGMEVASYLVAQYGEQRAWDLALHTWE---QMGLRSLCAQAQEGAGHSP--SFPY SPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ-----LPDTSGRRWREISA SLLYQ-ALPSSPDHE-SPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDET SGIYYTEIREREREKSEKGR----PPWAAVVGTPPQAHTSL----QPHHHPWEPSVRESL CS--TWPWKNEDFNQKFTQLL-------LLQRPHPRSQDPLV---KRSWPDYVEENRGHL IEIRDLFGPGLDTQE-PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR ELAQSKVVS--LAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCL HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE YFYRYFTDERQAIRAFR------------------------------------------- ---------------------------------------------LVKSNKELWALCLVP WVSWLACTCLMQQMKRKEKLTL-TSKTTTTLCLHYLAQALQA--------QPLGPQLRDL CSLAAEGIW-QKKTLFSPDDLRKHGLDGAIISTFL--KMGILQEHPIPLSYSFIHLCFQE FFAAMSYVLEDEKGRGKHSNC--IIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGEREM ENIFHCRLSQGR--N-LMQWV------------------------------PSLQLLLQP HSLESLHCLYETRNKTFLTQVMAHFEEM------------------GMCVETDMELLVCT FCIKFSRHVKKLQLI------EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRN LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTL-T ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRK PSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDV-S----KIFPIAEI AEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFP VAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEA VHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIH NALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTP LYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGI-------RLQV KDKKDETLVW--EALVKPG--DLMPATTLIPP--------ARIAV-PSPLDAPQ-LLHFV DQYREQLIARVTSVEVVL---DK-LHGQ--------------VLSQEQYERVLAENTRPS QMRKL-FS-LSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPL-SS-------- ------------------------------------------------------------ ------------------------------------------------------------ -- >P_pygmaeus_ENSPPYP00000008863 MA-------------GGAWGRLACYLEFLKKEEL--KEFQLLLANKA-HSRSSSGETPAQ PEK-TSGMEVASYLVAQYGEQRAWDLALHTWE---QMGLRSLCAQAQEGAGHSP--SFPY SPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQ-----LPDTSGRRWREISS SLLYQ-ALPSSPDYE-SPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDEM SGIYYAEIREREREKSEKGR----PPWAAAVGTPPQAHTSL----QPHRHPWEPSVRESL CS--TWPWKNEDLNQKFTQLL-------LLQRPHPRSQVPLF---KGSWPHYVEENRGHL IEIRDLFGPGLDTQE-PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGERFQHVFYFSCR ELAQSKVVS--LAELIGKDWTVTQAPIRQILSMPERLLFILDGVDEPGWVLQEPSSELCL HWSQPQQADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE YFYKYFTDERQAIRAFR------------------------------------------- ---------------------------------------------LVKSNKELWALCLVP WVSWLACACLMQQMKRKEKLTL-TSKTTTTLCLHYLSQALQA--------QPLGPQLRDL CSLAAEGIW-QKKTLFSPDDLRKHGLDGAVISTLL--KMGILQEHPIPLSYSFIHLCFQE FFAAMSYALENKKGKGKHSNC--IIDLEKLLEAYGTHGLFGASTTRFLLGLLSDEGEREM ENIFHCQLSQGR--N-LMRWV------------------------------PSLQLLLQP HSLESLHCLYETRNKTFLTRVMAHFEEM------------------GMCVETDMELLVST FCIKFSRHVKKLQLI------EGRQHRSTWSPTMVVLFRWAPVTDAYWQILFSVLKVTRN LKELDLSGNSLSRSAVKSLCKTLRCPRCLLETLRLAGCGLIAEDCKDLASGLRANWTL-T KLDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGVTSDCCQDLASVLSASPILKELD LQQNNLDDAGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRK PSVMTPIEGLDTGETSNSTSSLKRQRLRSETEPSHIAQADLKRLDW-SNPPAKASQSAGI TEGSSPEVAQVEPLCLPSPASQGDLHTKALGTDDDFWGPTGPVAAEIVDKEKSLYRVHFP VAGSYRWPNMGLCFVVREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEA VHLPHFVALQGGHVDTSLFQVAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIH NALRFLPVTSVVLLYHRLHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTP LYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGI-------RLQV KDKKDETLVW--EALVKPG--DLMPATALVPP--------ACIAV-PSPLDAPR-LLHFV DQYREQLIARVTSVEVVL---DK-LHGQ--------------VLSQEQYERVLAEDTRPS QMRKL-FS-LSQSWDRRCKDRLYQALKETHPHLIMELWEKGSKKGLLPL-SS-------- ------------------------------------------------------------ ------------------------------------------------------------ -- >C_familiaris_ENSCAFP00000022816 MA-------------CRVQWQLAWYLEMMGKEEL--KEFQLRLLEQQ-FWGDPPHALRAQ LGK-ARGLEVASRLVAQYGEQQAWVLALRTWE---EMGLSRLCAQSRAEAGLIPLS--PG SPMAPSMQSPNSPISTEVLRF---------IQDPRTRNSGQPLPPLLPNTSGHMWNEDPS SCKYQEGLPDSPEFQGSPHQESPSAPMPTAVLGGWEAPPQPSPVPGKQEAPKAGWPVAGT SGNHNPGERNRSQTESPQGR---SVPYLYVPSFPPLAGIT---------ERYQHQRRKKP YP--TWSWEDKDLHQIFIQLL-------LLHQPYPRGHESLT---KGRWHHG-AEKQGHL IEVEDLFGPGLGAQEEPQTVILHGVAGIGKSTLARQIRTAWKEGQLYKDRFRHVFYFNCR ELARSETMS--LTELITKAQAGPVLPAEQILSQPGRLLFILDDLDEPRWVLGEQESELHS SWSKQRPVHALLGSLLGKTVLPEVSLLVTVRTTALRRLVPSVGQLCWVEVLGFSESGRRE YFYKYFKNKSQATQAFS------------------------------------------- ---------------------------------------------LVELNPTLLTMCLVP LVSWLLCTCLKKQMQRGEELSLGSSQTTTALWLYYLSQALPA--------QLLGAQLRGF CSLAAEGFW-QGTNLLSRRDLRKHGFDEATISTFL--KTGILRKHPSPLNYHLAHRCLQE FFAAVSCVLGGEDGGSPHPDS--IRGAEKLLEVYEGHDLFGAPTTHFLFGLLSEQGEREM EAVFQCKLPRERKRD-LLRWAEA-------------------------GLWPRLS-APQP CSLHLLHCLYEIQDEDLLTRAMAHFHGR------------------SMCVQTGVEFLVCT FCFKFCSHVKRLQLN------ESRWDGQAWRPSSVALFSWVPVTDACWQALFSTLRASGS LKELDLSGNHLSHPAVQSLCKVLKFPCCHLETVRLAGCGLTAEGCSDLASALSASPAL-A ELELSFNLLLDAGAQHLSRGLRQPACRLRRLLLAGCSLTSRCCGALASALSTSPLLTELD LQQNELGDVGVRLLCGGLGHPTCQLTLLWLDQTQLSEEMTQMLRALQEEKPQLFVCSKWK PRATVPTEGLSRGETSG-TSSLKQQRQGSGRKSNAVAQARQPSLDRESGADSCSAP---F PERSCPQVGQVQLGRPPSPAAPWDLNTEPLRIGDGFWGPLGPVAPEWLAEDGSLYRVHLP VAGSYHWPDTGLRFEVRGPATIDIEFCVWDQHLPRAGLWHSWMVAGPLFDIKAEPGAVAT VCLPHFVDLQGSSVDTSLFYAAHLKDEGMLVETPARVEADHVVLENPSFSPIGVLLRTIH AALRFLPVTCVVLLYHHLRPGEVAFHLYLIPSDYSIRKAIDNEEKKFQFVQIHKPPPLAS LYMGSRYTVSGSEK--LEIIPKELELCYRSPREPQLFSEFYVSHLGSGI-------RLQV RDKKDDTVVW--EALVKPG--DLRPVASLAPP--------APAAR-PFPTDAPA-WLHFV DRHREQLVARVTSVDPVL---DM-LHGQ--------------VLSEEQYERVRAEATTPS QMRKL-FS-FSRSWDRACKDQVYQALKEAHPHLIMELWEKWGGNSGKQAPPG-------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_domestica_ENSMODP00000014409 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RDLNKEFVPLM-------LLHK--YKELKNIC---RKNTPVSVMTKQAHI IDMSELFGSD-ERKYVPQTVVLCGGAGIGKTILTRKIMLDWAEGDLFQDRFKNVIYVNCK TINLTLEMT--LVDLISKDWPDLQASIEAIMSNPKQLLFIIDGFDEVKWPFVEPEPELCH HWKEKCPVPVLLRSLLWKTIFPRSSLLIATRSSALMRFRCLIDDPNCVEVLGFTEANIEM YISKFFKSEAKVLKVLD------------------------------------------- ---------------------------------------------LLKVSDTLSEKCSVP LECWIICTCLKQQMERGEVPVL-LPQTTTDLYVSYLSFGLSH--DGSSSSQHHDLQLRRL CSLAAEEVW-AGKFTFNEDDLKRHGLD-VSDDSFL--NMYILEKKDKENCYSFIHGRFLE FFAAMFYVLEEKREERDYPAV--AVKDVIELLVQTRESDSEVSIMNFLFGLLNEETMRQL DRNFVYPTIQRGKAE-LLQWMIL-----------------------ESNIQRMINPLLHP DPLELFQCLYEIRQEELVRKTMKYFQSM------------------RLNLHTSKDILVSI FCIKLCYNLVNIHLHIS----RTLTNANHFFVSSLRMYN-SPHILIQWKELISVLLFKKS LIELELSGSFPDDRLMKIVYKEIMHPNCKLHTLSII------DFFKLLPPALQSILSVGS KAEEPKGKIKTIKKVPPIQSQARTSIILKLPCTLKCDCHLSICSILGSILDIRFEPGNES LSL-DLHRFIVSYCNNLLFSFSFNNIIPILTDSSNSDIVTLLLLSLMNKTQKLFNKLTYR RQLVTPTYMNKDGR-------LEKQKSYQNWDLIVWLEDSVSSFPE-------------- LFPEEVTPQTEAEVTSLLASFDPLKEEQLDLEKCLFLGPNGPVEPEWIDKKRNIYKVRLS MAGFYHCPYTGLGFDVRSEVTVDIEFGTWNQHLDWIQ-QQSWMIAGPLFHITVDPGVVTS VHLPHFVHLQGGKVDISLFKIAHFKEEGMVLENPTRMESSHAILENPSFSPMGVLLRIVH STFRFIPIYSTTLIYFRLRAEDITLHLYLIPSDCTIRKAIDEEEAKFHFLRLHKPSPVTP LYIGSRFLVSGSKH--LEIMPTELELCYQSAGECQFFSEIYTSNVKEII-------SLDL RDPK-GTVVW--GTLVRSG--RIKLVISLISM--QHGTFLSRPHQ-SLPYSLLP-ELHFV DQHRNQIISRVTSVDIIL---DR-LHSQ--------------FLSNEDYEHIRAEKTNPE KMRRL-FS-FSPSWSKDYKDHLYRVLREIHPHLMNEL-EHMEKILVRK------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >M_mulatta_ENSMMUP00000021383 IG--------------RKREAILKVLENLTPEELKNKKFKMKLGTVP-LREGFERIPRGA LGQ-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IVDL---TDQLVASYYEDYAVEFVVAV-------LLDM GMLEEAAQLP--RAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >T_rubripes_ENSTRUP00000017122 QK--------------TIKMAIKDSLENLGKQNL--NKFRSALLD----RREGPRVPVSR VED-ED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FLGI---TDVLVSTFGEFSAAEVTLDL-------LKQI KCNGEAEALE--SDLNASGLLKPKSTG-------------------RPSASVKVDDEHFV DKYRCALINRVSNIAPIL---DELLNKK--------------VIDQETYERIRGLPTCQE KIREL-YC-SGLKGGKACKDAFLKSLEKNERFLIDHLRTN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >P_pygmaeus_ENSPPYP00000008262 MG--------------TKREAILKVLENPTPEEL--KKFKIKLGMVP-LSEGFERIPRGA LGQ-LD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IVDL---TDKLVASYYEDYAAELVVAV-------LRDM RMLKEAARLQ--RAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >X_tropicalis_ENSXETP00000004042 RS--------------TLRETLVKTLEMLGRGKF--NEFKERLSGWD-VSPGYERIPMGS LQG-AD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GGKV---ADLIIDYYKNSYGVKVTLGV-------LGAI GAKSAATHLE--KIKVSDFIVGSYRA--------------------IPSVWTCRDGEHFM DRNRAALVVRMSDTNIML-VMDELLSEK--------------ILNDVQYNTVRSNRASHE MMRKL-YD-YARAWGPNQKNTFISILSKYDKWLILDLMEK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >G_aculeatus_ENSGACP00000016321 MP------------PKTTKKAIRDALANLPKDDF--EAFCHALID----RPGPPNVPYNK VEG-KS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FLLI---ADVLMSTFTEAKAPSVTAEL-------LEEI GCKQQATQLL------------KETSGQSSNS---------GAAGVNTTARHGRAEKHFV DEHRTVLIDRVTNVASIL---DDLLHEE--------------VISKVHYDEIMALSPRQS QMRKL-YD-PLYGAGRAAKEVFFKSLQAHENHLIQDLQKKE------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >D_rerio_ENSDARP00000055920 MA-------------ESFKEQLQEAFEDLGADNL--RKFKSKLGD----RRQEPRVTKSA IEKLKD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EIDL---ADLMVGVFTSKDAVSVTVEI-------LRAI KCNAVADDLL--RNTGQSESKGAPSDESKGAS-------------SKAVSKVAFSKVNFI DEHWKELIDRVNNVDPIL---DILRQKK--------------VITNEDYCTIRNKETPQK KMREL-LTGPITCAGNKGKEVLYDALRESNKFLMDDLEDAE------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >X_tropicalis_ENSXETP00000024833 AT-------------RKLEALLEKTLMNLPSSSF--KSFKNKLI-------GYKKITVHD LEL-AG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------REEV---VTKIIRCYTTKRGPEIVIKV-------LKAI KKDKFYGTVG--VQWAAGQGPTVHVAKLKLNF-----------------LSSPIGRKHFV DRHRAALIARVPHIDPIL---DGLLDDK--------------ILKPEQYDTVRSKGTCQE KMRQL-YV-YIKAWGDE-KEKFYEYLLEYNGPLVRDLENN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >G_aculeatus_ENSGACP00000016318 -----------------------------------------------------PRVRRNR VEG-KS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RLEV---VDVLVSTFTETGAVRVSVEV-------LKQI NCHEQANKLGVYENTKTLHPKTIEMFHEFVSA---------GAAGVNTPARD---EKHFV DEHRTALINRVTNVAAIL---DDLIDEE--------------VISKVHYDEIMALSPRQS QMRKL-YG-PLYGAGRAAKEVFFKSLQNNEKFLMQDLQK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >X_tropicalis_ENSXETP00000029880 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------YRLVVP REGLFCCSETGLQFRVESPADIEIEIGSWVEFLGPLH-QYRYDIVGPLFNITVKSGRVSA VYLPHYVCLRGGDVDIRTFRVAHYKDDNMILESPTSIEPFYVVLENPTFSPVGV--TVAN GRRRNIPTHGIVLLYSRYK-TGYTIHLYLMPHDVSLKKAVHKKETGNGFYWMDKPPRTRT IYTDRQYIVRGPED--AEINPEELELYFNVKSELYNYSEIYLEEIEDKI-------HLQL TCEGENTLAW--QTRLRAG--IISNVFCFSFP--------------------PTDGQHFI ERHRAALIARVSNIDLIL---DGLLNND--------------ILKQEQYDTVRSNRTPQE RMRQL-YD-CVRAWGKIEKETFYHILFLHERALVTDLL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >O_latipes_ENSORLP00000020969 -----------------------------------------------------PRVRRGR VDD-KN------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------FLVV---ADVMVSTFTEKKALLVAAEI-------LRGI QCAAEAQQLP--EATGSLRKTEGSMNEAGISS-------------SSGSVSVTKGRKHFV DEHFSQLIDRVTCVEPIL---DQLLQED--------------AIQQEAYNLIRSKPTSQA KMREL-LD-HLRA-SPAHKDIFYNILKKQQKHLLEDLEGN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >O_anatinus_ENSOANP00000018610 TT-----------MAPAPRDKLLLSLKELREEEL--RTFKFKLLGIP-LQDGYFHVPRGE VDG-LKPVELADLLILYYGEKYAVMVVLEVLK---AMHMNGVVETLGQDTWEDSR----- ---------------------------------------ET------------------- ------------------------------------------------------------ ---------------------------------------------------YRERMKKSL ER------------------A-------EESLPGAQEEEGPAPVAEGNGSSGIGEKEVHS IGLETLLDPEEEGTDSPRTVVLHGEAGIGKTTLAKKLMLDWASGDFYPDTFDYTFLVSCR EINLMAEKS--LAELICHCYGDGHAPVTEVLKRPERLLFIIDGLDELKYSLEEEGEEPGS ELRDKQPVQTLLSSLVRKKLLPESSLLITTRPRALEKLQPLLEDPRYVEILGFSEVEREE YFFKFFTDENKAKKAFN------------------------------------------- ---------------------------------------------FVQRNENLSSLCSIP LVCWFSCTCLKQQMVRGEPLTH-TSKTITDVYMSYISIFLQP--DRARAKQPAYPTLKRL CSLAADGIR-NRKILFQEDDLRQHSLDQADIAA-FLSKANFRQESKGETFYSFIHYSFQE FFSALYYMLEGDGNESN------RDVNALLEKQEQTRSDGSALTLRFLFDFLSQETVSTL EIKFSYKIPPKLQKE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LKCIKARVK SLRHF-RT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_domestica_ENSMODP00000037465 MA--------------RGRDLILQSLNNLNDEEF--TRFKFKLHEMP-VRISFVYLPRKT VQS-LT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RLNV---ANWMVSSLPENGGVKLTTIM-------LQGI GKQEEAVRLE--NAA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >G_aculeatus_ENSGACP00000016325 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NTTAPDGSAEKHFV DEHRTALIDRVTNVAAIL---DDLLDGE--------------VISKGSYEEIMALSTRRD QMRKL-FSGPLDGSGRAGKDLFYKILEKKEKFLMKDLQKKE------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_musculus_ENSMUSP00000101660 MDAAGASCSS---VDAVARELLMATLEELSQEQL--KRFRHKLRDAP-L--DGRSIPWGR LER-SDAVDLVDKLIEFYEPVPAVEMTRQVLK---RSDIRDVASRLKQQQLQKLGP-TSV LLSVSAFK-------------------------------KK------------------- ------------------------------------------------------------ ---------------------------------------------------YREHVLRQH AKVKERNARSVKINKRFTKLL-------IAPGTGAVEDELLGP-LG--EPEPERARRSDT HTFNRLFRGNDEESSQPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYHSQVDFAFFMPCG ELLERPGKR-SLADLVLDQCPDRAWPVKRILAQPNRLLFILDGADELP-TLPSSEATPCK DPLEATSGLRVLSGLLSQELLPGARLLVTTRHAATGRLQGRLCSPQCAEIRGFSDKDKKK YFFKFFRDERKAERAYR------------------------------------------- ---------------------------------------------FVKENETLFALCFVP FVCWIVCTVLQQQLELGRDLSR-TSKTTTSVYLLFITSMLKS---AGTNGPRVQGELRTL CRLAREGILDHHKAQFSEEDLEKLKLRGSQVQTIFLNKKEIPGVLKTEVTYQFIDQSFQE FLAALSYLLEAERTPGTP-----AGGVQKLLNSDAELRGHLALTTRFLFGLLNTEGLRDI GNHFGCVVPDHVKKD-TLRWVQGQSHPKGPPVGAKKTAELED---IEDAEEEEEEEEDLN FGLELLYCLYETQEEDFVRQALSSLPEI----------------VLERVRLTRMDLEVLN YCVQCCPDGQALRLVSCGLVAAKEKKKKKKSLVKRLKGSVTGTNL------------VLS LYSSQSTKKQPPVSLLRPLCETMTTPKCHLSVLILSHCRLPDAVCRDLSEA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LKVAPALREL-----GLLQSRLTNTGLRLLCEG-------LAWP KCQVKTLRMQ--LPDLQEVINYLVIVLQQSPV------------LTTLDLSGCQLPGVIV EPLCAALKHPKCSLKTLS------LTSV--------------ELSENSLRDLQAVKTSKP DLSII------------------YSK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_musculus_ENSMUSP00000097795 MA-------------KTLGDHLLNTLEELLPYDF--EKFKFKLQNTS-LEKGHSKIPRGH MQM-ARPVKLASLLITYYGEEYAVRLTLQILR---ATNQRQLAEELRKATGTEHLIEENR VGGSVQSSV--ENKAKSVKVPD------VPEGDGTQQNND-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ES-DTLPSSQAEVGKGPQKKS-------LTKRKDQRGPESLDSQTKPWTRSTAPLYRRTQ G-----TQSPGDKESTASAQLRRNVSSAGRLQGL----YNNAPGRRESKKAEVYVYLPSG K------------------------------KRPRSLEITTYSREGEPPNSEVLPTQEET RNGSLI-----------------RMRTATLNGRTTGALEKGTGIPEHSMVLDEKTFRNMS SKTSLIGEERCPTSWTE------NGNGSPETTESSGETAGSILSD---PEVPLSLCEKPA KTPEDPASLGQAACEGTLLQVSRKCDAGPEKCTFTHLALQVASNFGRSQDKAVCPLCHTQ EGDLRGDTCVQSSCSC-SIAPGDPKASGRCS-ICFQCQGLLA---RKSCEA--------- --QSPQSLP---QCPRHMKQVLLLFCEDHREPICLICRLSLEHQGHRVRPIEEAALEYKE QIREQLERLREMRGYVEEHRLQGDKKTDDFLKQTEIQKQKISCPLEKLYQLLEKQEQLFV T----------------------------------------------------------- ------------------------------------------------------------ ---------------------WLQELSQTISKVRETYYTRVS----LLDEMIEELEAKQD QPEWDLMQ-DIGITLHRA--KMMSASELLDTPPGVKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KLHLLYQKSKSVEKNMQCFSEMLSSEMAFSASDVAKWE GRQPSATQVQ--GLVPTVHLKCDGAHT-----------------QDCDVVFYPEREAGGS EPKDYLHPQPAQDTPELHEIHSRNNKRKFKSFLKWKPSFIGSTLGEAHRSALPARHSSSC SYRDL-------------------DQAAAHPNLIFSMI---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >O_cuniculus_ENSOCUP00000004286 MA-------------KTPSDHLLNTLEELVPYDF--EKFKFKLQNTS-LEKEHSRIPRGQ LQM-ARPVRLATLLVTHYGEEHAVRLTLQVLR---AINQRLLAEELHRATEQ-------- -----CRVSGRREGPGSPKAAE------GPEGEGQRQSGD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-ASSPSGQPEAGRGPQKKP-------QVKRRE---SASADAQGRPGA-------RRSP V--LGRP--PGDRPGPTSARLRRNASSAGRLQGQ----CGAYPGKTEQKKLE--VYLPSG K------------------------------KRPKSLEL-ISSRDREPPNPGTLLPQEEA GTRKPASAAT-------------PRGAATHDAEAAQALEKSSRNPDH------------- ------------------------------------------------------------ ----------------------------------------------RPQDKAACPLCHTQ EGDPVGTTCRRDSCSC-PVAPAHPRASGGRLPGCPHCQVSLA---WKSSRG--------- --LSPPPLP---HCQRHMK--QLLFCEDHGEPTCLICSLSQEHRGHRVRPIEEVALEYRE QIQKQLEHLKQLRRCGEERRSQGDEKMEKFLKQTETQRQRVCCQLEQLFQFLEEQEQLFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------WLEELGQTIGQVREKYGTRVSWNIALLDELIGELEAKQC KSEWELMQ-XXXXXXXXA--KAVTVPEPWATPPEVKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLYQKSEFIEKSMESFSETLRSEM--ETFNVPELI SAQAHAVNVT--LDAETSHPNLIFSDDLKSMRLGNKWERLPEEPERFDSCIIALGSPSFL SGRHYWEVEVGDKTAWILGVCKASMSRKGSMILSPENGYWV-VMMKQNEYRVSTFPPTRL WMRELPRRVGIFLDYKTRNISFYNVTARSHMYTFTSFSSS-GPLQPIFSPGAHDRGKNMG PLTICPVGDQRLR----------------------------------------------- ------------------------------------------------------------ -- >R_norvegicus_ENSRNOP00000019808 MDAAGASCSS---SEAVARELLLAALQDLSQEQL--KRFRHKLRDAP-L--DGRSIPWGR LEH-SDAVDLTDKLIEFYAPEPAVDVTRKILK---KADIRD------------------- ---------------------------------------KK------------------- ------------------------------------------------------------ ---------------------------------------------------YREHVLRQH AKVKERNARSVKINKRFTKLL-------IAPGSGAGEDELLGT-SG--EPEPERARRSDT HTFNRLFRGNDDEGPRPLTVVLQGPAGIGKTMAAKKILYDWAGGKLYHSQVDFAFFMPCG ELLERPGTR-SLADLILEQCPDRTAPVRRILAQPHRLLFILDGADELP-TLAAPEATPCR DPFEATSGLRVLSGLLSQELLPSARLLVTSRNATLGRLQGRLCSPQCAEVRGFSDKDKKK YFFKFFRDERKAERAYR------------------------------------------- ---------------------------------------------FVKENETLYALCFVP FVCWIVCTVLLQQMELGRDLSR-TSKTTTSVYLLFITSMLKS---AGTNGPRVQGELRML CRLAREGIL-KHQAQFSEKDLERLKLQGSQVQTMFLSKKELPGVLETVVTYQFIDQSFQE FLAALSYLLDAEGAPGNS-----AGSVQMLLNSDAGLRGHLALTTRFLFGLLSTERIRDI GNHFGCVVPGRVKQD-TLRWVQGQSQPKVATVGAEKKDELKDEEAEEEEEEEEEEEEELN FGLELLYCLYETQEDDFVRQALSSLPEM----------------VLERVRLTRMDLEVLS YCVQCCPDGQALRLVSCGLVAAKEKKKKKKSFMNRLKG---------------------- ---SQSTGKQPPASLLRPLCEAMITQQCGLSILTLSHCKLPDAVCRDLSEA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LKVAPSLREL-----GLLQNRLTEAGLRLLSQG-------LAWP KCKVQTLRIQ--MPGLQEVIHYLVIVLQQSPV------------LTTLDLSGCQLPGTVV EPLCSALKHPKCGLKTLS------LTSV--------------ELTENPLRELQAVKTLKP DLAII------------------HSKLGTHPQPLKG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >M_domestica_ENSMODP00000011060 ---------------------LVRYLEELTFEEL--KKFKLFLEDSP-PKEKFLRIPRSQ MKK-ADNTDMAELMVHHYGEGEAWDVALMIWE---KMGLRELWEQAKREAPQMGKYGETF AYKDERLG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------HRENKS QRILSCQTTYRNRIMEKFRVM-------RDRNSCPGEYENLH-------HRFTRLLLLQE YQVASLFDPDKKREAHPQVVVLQGAAGIGKTTLARKVILDWAEGNLYQDKFDYVFYLHCR EMNHLREKKIRFADLIANDWPFLEASMKRILSHPEKLLFVIDGLDELKFSCDEHSYDLCK DWNLQQPVPILLSSLLRKTMLLESSLLITTRLTALEKCDFLFENPRHVEILGFSEEDRWK YFCKFFGDEDQAQQAFS------------------------------------------- ---------------------------------------------LIVNNETLFTMCFVP LMCWIICTCMKQQMRRKKDLKQ-ASKTTTTLYMCYLSSLATP-----GARSCSVQHHRSL CRMAAEGIW-EGKILFDGDDLRRHGLEASDVSA-FLDMHIFQKDSDSENCYSFIHLSFQE FFAAMFYALGEEKETGGRAVPPIPGVKDLLAKCRDSATSFVALTVHFLFGFLNADNRKRL EEIYDCKISQEIKLE-LLQWIQA------------------------VTEQQHKDPSLRN DLLEMFSHLYETQDEEFVTTAMAHFQEI------------------SLNIYSKLHFLISV FCIKFCHNLGKIRLNIAW---MYRSKIQSAGITQTWQLPFFQLAVVDWQHLFSVLSKNQN LRTLDLSGTELANSAVNALCSELSQSSCKLQKLSLSKCQLTASCCQHLSSLLKNNKNL-T YLDLSMNFLGDEGIKALCEVLRNQNCNIQELNLSRCRFSDACCKNLSSALMAHGNINILD LSENTLADVGMNLLCEALGSSDCNLQELKLSQCHFTDACCQDLSTCIK-NQSLIHLDVSG NFLQDSGIRLLCEALRHPTCNLQKLLLSLCHITDSSCQDVSFA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LKNNRSLIHL-----DLGCNNLYNHGVKLLCEA-------LENQ NCNLQTLELW--NCQLSAACCHEFSSVLKKNQ-----------SLTHLNLGANPLRNNGV KVLCEALGNQNCKLQKLK------LCKC--------------LLSAVGCRYLSTALKSNQ NLTHL--KLTGNGLGDDGVKLLFEALKNSDCKLQKL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >B_taurus_ENSBTAP00000025458 MV-------------RTRSDHLLYSLEELLPYDF--EKFKFKLQNTS-LEKEHLRIPRGQ LQT-AEPVKLASLMVNHYGEEYAVQLTLQVLR---AINQHLLAEELHQVISPECRIQESD TDSSAMSGSSGEMKPKSLKTPD------GLEGDKQRQSADG------------------- ------------------------------------------------------------ ---------------------------------------------------AGCPPSSQP GA-GSPPSSQPEAGRGPQKKP-------LGKQRDQKGSEGLEVQSKLGAKNTTLSSKRSP F--LTKVPREKEKGSCPSVRLRRNASSAGRLQGLTSGSLAGSPGRKETKISE--VYLPSG K------------------------------KRPKSLELTISPEETGPLNPEILLLQEKM NTENPSSATT-------------ASEVATLKTGPTVTLEKGFRNPGHATT---------- ------------------------------------------------------------ ---------------------------------------------RRLQDKAVCPLCRAQ EGDPVGGSCVHISCSC-SAASRDPEASLSRSSSCPRCQDLLP---GKSHGSHEWQEGLQM ASLNPKSLP---QCKRHMKQAQLLFCEDHGELICLICRLSQEHRGHRVRPIEEAALEYKE QIQKQLDHLKELRKSGEEQRSQGDKKTVNSLKQAETQKQRIQYQLEQLCQFLEQQERLFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------WLEELGQTIGQVRETYGTQRTRDIALLDKLIGELEAKQC QPEWELMK-DIGVTLHRA--KMVTVPELWATPPEVKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIHLLYQKSEFVEKRVKHFLETLRSEV--ETFNGPEVR NSVLSAVNVI--LEAETVHSNLIFHQSLGE----KKCDHLPASP---------------- -GKFYREVKVGDKPGWVLGVCNAGTSSKENMTLSPENGHLACTLLQ-------------I QMGEPCWHGGISVDYKMG-ISFYNVTAKSHITATGYFPP--GPLQPILSPRTHDGEKNMD PLTICPVGVATAS----------------------------------------------- ------------------------------------------------------------ -- >P_troglodytes_ENSPTRP00000013131 MA-------------KTPSDHLLSTLEELVPYDF--EKFKFKLQNTS-VQKEHSRIPRSQ IQR-ARPVKMATLLVTYYGEEYAVQLTLQVLR---AINQRLLAEELHRAAIQEYSTQENG TDDSAASSSLGENKPRSLKTPDHP---EGNEGNGPRPYGG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-ASLRRSQPESGRGLSRKP-------LSKRRD-KASEGLDAQGKPRTRSPALPGGRSP G--PCR----APEGDQAEVRLRRNASSAGRLQGL----AGGAPGRKECRPFE--VYLPSG K------------------------------MRPRSLEVTISTGEKAPANPEILLTLEET TAANLNSATE-------------PRARPTPDGGASADLKEGPGNPEHSVT---------- ------------------------------------------------------------ ---------------------------------------------GRPPDTAASPRCHAQ EGDPVGGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHE---RKSPGS--------- --LSPQPLP---QCKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKK KIQKQLEHLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKEC QSEWELLQ-DIGDILHRA--KTVRVPEQWTTPQEIKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLHQKSEFVEKSTKYFSETLRSEM--EMFNVPELI GAQAHAVNVI--LDAETAYPNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFL SGCRYWEVEVGDKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRL LIKEPPKRVGIFVDYGVGSISFYNVTARSHIYTFASCCFS-GPLQPIFSPGTRDGGKNTA PLTICPVGGQGPD----------------------------------------------- ------------------------------------------------------------ -- >M_mulatta_ENSMMUP00000023620 MA-------------KTPSDHLLSTLEELVPYDF--EKFKFKLQNTS-VEKEHSRIPRSQ IQR-ARPVKMASLLVTYYGEEYAVRLTLQVLR---AINQRLLAEELHRAAVQEYSTQENG TDDSAASSSLEENKPGSLKTPDHPEGKEGKEGNGPRSCGD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ WA-ASLRYSQPEAGRGLSRKP-------LSKRRE-KASESLDVQGKPRTRSPALPGGRSP GPSPCR----APEPGQAEVLLRRNASSAGRLQGL----AGGAPGRKECRLFE--VYLPSG K------------------------------KRPKSLEFTISTGEKAPPNPETLLTVEET TAANPDSATG-------------AQARPTPDGGASADLEKGPGNPEHSVT---------- ------------------------------------------------------------ ---------------------------------------------GRPPDKAASPRCHAQ EGDPVGDICVRDSCSCPEAASEHPQASGRCSPDCPRCQASHE---RKSMGS--------- --LSPQPLP---QCKPHMKQVQLLFCEDHREPICLICSLSQEHRGHRVRPIEEAALEHKK QIQKQLEHLKELRKSGEEQRSYGEGKAVNFLKQTEALKQRMQRKLQQVYHFLEQQEHVFM A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SLENVGHMVGQIRKAYDTRISQDVALLDALIGELETKQC QSEWDFLQ-DIGDILHRA--KTVPLPERWTPPQEMKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLHQKLEFVEKNAKYFLETLRSEM--EMFNVPELI GAQAHAVNVI--LDAETAYPNLIVSDDLKSVRLGNKRERLPDGPQRFDSCIVVLGSPSFL SGHHYWEVEVGDKTAWILGACKASISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRL LIKVPPKRVGIFVDYRVGSISFYNVTARSCIYTFTSCCFS-EPLQPIFSPGTHDGGKNTA PLTICPVGGQGPD----------------------------------------------- ------------------------------------------------------------ -- >H_sapiens_ENSP00000219596 MA-------------KTPSDHLLSTLEELVPYDF--EKFKFKLQNTS-VQKEHSRIPRSQ IQR-ARPVKMATLLVTYYGEEYAVQLTLQVLR---AINQRLLAEELHRAAIQEYSTQENG TDDSAASSSLGENKPRSLKTPDHP---EGNEGNGPRPYGG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-ASLRCSQPEAGRGLSRKP-------LSKRRE-KASEGLDAQGKPRTRSPALPGGRSP G--PCR----ALEGGQAEVRLRRNASSAGRLQGL----AGGAPGQKECRPFE--VYLPSG K------------------------------MRPRSLEVTISTGEKAPANPEILLTLEEK TAANLDSATE-------------PRARPTPDGGASADLKEGPGNPEHSVT---------- ------------------------------------------------------------ ---------------------------------------------GRPPDTAASPRCHAQ EGDPVDGTCVRDSCSFPEAVSGHPQASGSRSPGCPRCQDSHE---RKSPGS--------- --LSPQPLP---QCKRHLKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKK KIQKQLEHLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHFFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKEC QSEWELLQ-DIGDILHRA--KTVPVPEKWTTPQEIKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLHQKSEFVEKSTKYFSETLRSEM--EMFNVPELI GAQAHAVNVI--LDAETAYPNLIFSDDLKSVRLGNKWERLPDGPQRFDSCIIVLGSPSFL SGRRYWEVEVGDKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRL LIKEPPKRVGIFVDYRVGSISFYNVTARSHIYTFASCSFS-GPLQPIFSPGTRDGGKNTA PLTICPVGGQGPD----------------------------------------------- ------------------------------------------------------------ -- >E_caballus_ENSECAP00000005035 MA-------------KTPSDHLLYSLEELVPYDF--DKFKFKLQNTS-LEKEHSRIPRGQ IQT-AKPVKLATLLVNHYGEEYAVRLTLQVLR---AINQNLLAEELHRVTGPEYLIQEHG PDSSAMSCSSVENNPKSLRISD------GPQGDRQWQSGD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ RA-ASLPSGQLEAGRGPQKKP-------QVRSRDQKGSEGLDVQGKLGARSVTPSSRRSP F--PGKL---QEKGMNPGSGVRRNASSAGRLQGVSSGLFSGSPGRKESKTPE--VNLPSR K------------------------------KRPKSLEFTISSGEGEPFNPETLLLQEKI R----NSGAT-------------SSEVATLDIGATMALEKRSRNPEHSMILEWGAFRNTV SHVSLAREERTREHPESRAPLEKHGTEDPETPETLGEVVGGVLHKPSNSEVPLSSSKKGP QNPEDLASLGMDCHE------------------------------MRLQDKAVCPLCRAQ EGDPDGGTCVHDSCSC-SIASRNLKASDGHSPSCPQCQASLP---GKSSGGQERQEGQQM ASLISKPLP---QCERHMNQVQLLFCEDHGEPICLICRLSQEHQGHWVRPIEEAALEYKE QIQKQLEHLKGLRKSGEEQRSQGEKTTADFLKKTEIQKQRIQCQLEQFYRFLEEQEQLFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------WMEELGQTIGQVRETHGTQVSKYTALLDELIGELETKQC QPEWELMQ-DIGVTLHRA--KMVTVPEPWATPPEVKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KLHLLYQKSEFVEKSMKHFS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >P_pygmaeus_ENSPPYP00000007958 MA-------------KTPSDHLLSTLEELVPYDF--EKFKFKLQNTS-VEKEHSRIPRSQ IQR-ARPVKMATLLVTYYGEEYAVQLTLQVLR---AINQRLLAEELHRAAIQEYSTQENG TDDSAASSSLGENKPRSLKTPDQP---EGKEGKGPRPFGD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-ASLRCSQPEAGRGLSRKP-------LSKRRE-KASEGLD-QGKPRTRSPALPGGRSP G--PCR----APEADQAEVRLRRNASSAGRLQGL----AGGAPGRKECRPFK--VYLPSG R------------------------------TRPRSLEFTISTGEKAPSNPEILLTLEET TAANLDSATE-------------PRARPTLDGGASADLEEGPGNPEHSVT---------- ------------------------------------------------------------ ---------------------------------------------GRPPDTAASPRCHAQ EGDPVGGTCVRDSCSCPEAVSGHPQASGSRSPGCPRCQDSHE---RKSTGS--------- --LSPQPLP---QCKRYMKQVHLLFCEDHGEPICLICSLSQEHQGHWVHPIEEAALGHKK QIQKQLEHVKKLRKAGEEQRSYGEEKAVSFLKQTEALKQRVQRKLEQVYHFLEQQEHFFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKEC QSEWELLQ-DIGDILHRA--KTVPVPEQWTTPEEVKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLHQKLEFVEKSAKYFSESLHSEM--EMFNVPELI GAQAYAVNVT--LDAETAYPNLIFSDDLKSVRLGNKRERLPNGPQRFDSCIVVLGSPSFL SGRHYWEVEVRDKTTWILGACKASISRKGNMTLSPENGYWVVIMMKENEYQASSVPPTRL LIKEPPKRVGIFVDYRVGSISFYNVTARSHMYTFTSCSFS-GPLQPIFGPGTRDGGKNTA PLTICPVGGQGPD----------------------------------------------- ------------------------------------------------------------ -- >C_familiaris_ENSCAFP00000009685 MDPPEACCRKVRPTLAVARDLLQATFEDLNQEQL--KRFRHKLRDAT-L--DGRNIPWGR LDG-LDAMDLAAQLTHFYGPEPALDVTRKTLK---RADMLDVAARLKEQQLQRLGPSSST LRSVSEYK-------------------------------KK------------------- ------------------------------------------------------------ ---------------------------------------------------YRDHVLQQH AKVKERNARSVKINKRFTKLL-------IAREGAALPDEALGC-TKELEPEPQRARRSDT HTFNRLF-GRDEEGQRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYHGQVDFAFFLPCR ELLERPGAC-SLADLVLDQCPQRKAPLKPMLARPERLLFILDGADDLP-PL-APHAAPCT DPFQAADAARVLGGLLGKTLLPAARLLVTARTTAPGRLLDRLCSPQCAEVCGFSDKDKKK YFHKFFRDERLAERAYR------------------------------------------- ---------------------------------------------FVKENETLFALCFVP FVCWIVCTVLRQQLELGQDLSR-TSKTTTSVYLLFIISVLSS--APAADAPRMRAELRKL CRLAREGTL-GHRAQFAEKDLERLELRGSKVQTLFLSKKELPGVLQTDVTYQFMDQSFQE FFSALSYLLEEER------------DLRALLQGES----HLTLTTRFLFGLLNPDRVSDM QRHFGVAVPERVKQD-VLLWMQEQGQGRRRAA-PEKTAGTDA---AEDAEEPEEEECEPN YPLELLYCLYETQEDAFVRQALRCLPEL----------------ELERVRLSRMDLVILS YCVRCCPPGQALRLVSCGLAPA---QKKKKSLMKRLHSSLGGSS---------------- --SSQASKRKPQPSPLRPLFEAMTDEHCGLNSLTLCRCKLPDSVCHDLSEA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LREAPALTEL-----GLLHNQLSEAGLRVLLEG-------LAWP QCRVQKLRVQ--QPSLQEAPQYIISILRQS-V------------ASTLYLGDCQLPGPVV TSLCAALQHPGCRLQTLT------LTSV--------------ELSKESLKELQAVKTAKP GLVII------------------HPALDSHPKPSKGLSDAL------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >C_familiaris_ENSCAFP00000033373 MI-------------KTPSDHLLDSLEELLPNDF--EKFKFKLQNTS-VEKDHSRIPRGQ VQN-AKPVKLANLMINHYGEENAVRLTLQVLR---AINQNLLAEELDKAIGPEYLIQESG TYSSAMSCSFGENKSKGLKISD------GLEGERQRQSGD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-VSLPANQHEAGKGSQKKP-------QSRRRDQKSSGCPDMLGKPGARSLSSSSKRSP F--PGKL---QGEKGSPTDHLRWNASSLG-LQELSSGSFTGSLGRVKSKIPG--ERLSSG Q------------------------------RRPRSLEFTIFSRERELLNPETLLSQEKM RSDHTDSAAT-------------PSEVATLDVGATVAPEKGSRNPEHSMI---------- ------------------------------------------------------------ ---------------------------------------------RKPQDEAMYPLGHAQ EGDPADGTYVHDSYRP-AIGSEDLKTSGRYSPSCLSSQASLP---IKNSGDVQQKEDLQM AILSPRSLP---QCERHMKQVQLLFCEDDREPICLICSLSQEHRGHRVRPIEEAALEYKV KIQKQLEYVKELRKSGEEQRSQGDKKTAKFLKQMETQKQRIQHQIEQLYHILEQQEKFFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SFEDLNRTIGQVRETYSTQVSRDIALLDELIGELEAKQF QPEWELMQ-DIGVTLHRV--KMVTVPKLWNTPLEVEK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLFYRKSEFVEKSMKYLSEMLRSEI--DIFNVPELI CAQAHAANVI--LDAETAHPNLIFSNNLKSVRLGNKWNRLPDNPERFDSCIIALGLPSFF SGRHYWEVEVGNKTGWILGICKASMSRKGSMTLSPDNGYWVVIMMKRSEYQVSTIPPTRL QLREPPKRVGIFLDYKAGDISFYNVTNKSLIYAFTGFSSS-EPLQPIFSPGTHDGGKNMD PLTICPVGDQEPH----------------------------------------------- ------------------------------------------------------------ -- >G_gorilla_ENSGGOP00000015416 MA-------------KTPSDHLLSTLEELVPYDF--EKFKFKLQNTS-VEKEHSRIPRSQ IQR-ARPVKMATLLVTYYGEEYAVQLTLQVLR---AINQRLLAEELHRAAIQEYSTQENG TDDSAASSSLGENKPRSLKTPDHP---EGKEGNGPRPYGG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GA-ASLRCSQPEAGRGLSRKL-------LSKRRE-KASEGLDAQGKPRTRSPALPGGRSP G--PCR----APERDQAEVRLRRNASSAGRLQGM----AGGAPGRKECRPFE--VYLPSG K------------------------------MRPRSLEVTISTGEKAPANPEILLTLEET TAANLDSATE-------------PRARPTPDGGASADLKEGPGNPEHSVT---------- ------------------------------------------------------------ ---------------------------------------------GRPPDTAASPHCHAQ EGDPVGGTCEHDSCSCPEAVSGHPQASGSRSPGCPRCQDSHE---RKSPGS--------- --LSPQPLP---QCKRHMKQVQLLFCEDHDEPICLICSLSQEHQGHRVRPIEEVALEHKK KIQKQLEHLKKLRKSGEEQRSYGEEKAVSFLKQTEXLKQRVQRKLEQVYYFLEQQEHFFV A----------------------------------------------------------- ------------------------------------------------------------ ---------------------SLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKEC QSEWELLQ-DIGDILHRA--KTVPVPEHWTTPQEIKQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KIQLLHXKSEFVEKSTKYFSETLRSEM--EMFNVPELI GAQAHA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- >M_mulatta_ENSMMUP00000019672 MA---------MTKARNPREALLWALSDLEENDF--KKLKFYLRDMT-LSEGQPRLARGE LEG-LIPVDLAELLISKYGEKEAVKVVLKGLR---VMNLLELVDQLSHVCLHDYR----- ---------------------------------------EI------------------- ------------------------------------------------------------ ---------------------------------------------------YREHVRCLE ------EWQEAGVNGRFNQVL-------LVAKSSSESPESPA--------HPIREQELDS VMVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGSLYPGRFDYVFYVSCK EVVLLLESK--LEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKK--- --RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERAR YFSSYFTDEKKADSAFD------------------------------------------- ---------------------------------------------IVQKNDILYKACQVP GICWVVCSWLKGQMERGKAVLE-TPRNSTDIFMAYVSTFLPPVDDGGCSEFSRHRVLRSL CSLAAEGIQ-NQRFLFEEAELRKHNLDGPRLAA-FLSSNDYQLGLAIKKFYSFRHISFQD FFHAMSYLVKEDQSRLGKESR--REVQRLLEAKEQEGNDEMTLTMQFLLDILKKDSFLNL ELKFCFRISPCLAQD-LKHFKEQ------------------------------MESMKHN RTWDLEFSLYEAKIKNL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VKGI QMNDVSFKIK--HSNEKK------------------------------------------ ------------------------------------------SQSQNSFSVKSSLSHGPK EKQKH----PSVHGQKEGKDNIAGTHKEASTGKGRGTEET-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >M_domestica_ENSMODP00000020549 MA-------------KTLSDHLLHTLESLVAYDL--EKFKFKLQTAN-LDKDQVRIPHGR LQNATGPVKLADLLINYYGERYAVKLTLQVLQ---AINQNLLVEELSQAITPECLTQECA TEISGISAFSRTTGSKTLEITV------PLKGILENEDANF------------------- ------------------------------------------------------------ ---------------------------------------------------QGPNEDIMD GIQVPISSSQLHAGQEYQEDSPETDASLVLESNRYENSEGFVTFGKKAYRNQAP------ ------------------------------------------------------LFLSA- -------------------------------KRIPNQEFDDFSGEQNHPNQKSMNKEHGN SEVSVSLGETTILYKDQVPESPKEKIFGNVDTSMLSG-EKGTKDPGNWYLKEAHEGIFHN IYF--------------------------------------------------------- ---------------------------------------------KPYKYYSSCSICQAM VVNPSKISWGNHIRSHYNVGHN----------VCLKCQAMFPKNFQHSRSLENIPTDYRG PKLNPQSMP---QCECHPKQLQRLFCKDHGKTICLICSMSPEHRGHRMLPIEEAAQSYKE QIQNQLEHLKKVRETAEEKKSQGNKTITAFLNKTETQKMQIMSQLKELHDFLEKQERLFL V----------------------------------------------------------- ------------------------------------------------------------ ---------------------WLEELSKTIFRSKEDYITKASQEISLLEELMGELEEKQK QPAWEFLQVKMSDSLYGEVAEWAFLPEEWALSPELKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KTHLLFWKSQSVERSMRQFIASLQSEM--ETFKILQLR EVQLYSANVT--LDPETAHPKLIISDDRKHVRLGKKCGKVFDGPQRFNDSVIVLGYPSFT SGKQYWQVDVGDKTSWILGVCKNSVNRKGSTAFSPGNGYWLVMMMKKNEYSASTIPPTPL SLKEPPRCVGIFMDFEAGDISFYNVTARSHIYTFSFSSSSSGPLRPVFSPGIQDRGKNAD PLTICSV----------------------------------------------------- ------------------------------------------------------------ -- >G_aculeatus_ENSGACP00000016327 MA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EAARPSDGSPGVDV-------MAEG GCT----------------------------------------------------GEHFV ERHRVELIKRVSNIKPIL---DELLRQK--------------IISRYSYDQMKPLPTSQQ KMVEF-FRWPLPVSGSEGNEMFYKLLNEHEPHLIHELRRTEVEAGLPVRELLLETFNDLR DKELKRFNWLLLWKFFLCSFPRHLWKRLQRFHTAKNLVDVMVQTWGQRSMEVTKEVLVDM NRTDLVQRLPTWGHKEEHSLGELWLGLNPELVETMASAIELLLETLKDLTDRELKMLQHL FL >R_norvegicus_ENSRNOP00000057719 MA-------------NTRVDHLLNTLEELLPYEL--EKFKFKLHTTS-LEKGHSRIPLSL VKM-ARPIKLTRLLLTYYGEEYAVRLTLQILR---ATNQRQLAEELHKATGPEHLTEENG VGGSVQSSA--ENKDKGVKGSD------VPGEDEAQQNDD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ES-DILPPIQAEVGKGPQKKS-------LAKRKDQRGPESLDSQTKPGARSAAPLYRRTL V-----TQSPGDKENRAGAQLRRNASSAGRLQGL----YSNVPGRREIKKAE--VYLPSG K------------------------------KRPRSLEITTYSKEGEPPNSEALPTQEET RNGSLI-----------------RTRTATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMS SKISLTREKRCTASWTE------NGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLA QTPEDPASLGQAASKGILPQRSRKRDAGPEKCTFTHLAQQVASNFGRSRDKVACPLCHTQ -GELPAKACVQSSCSC-SVAPGDPKASGRHS-ICFQCQSSRA---GKSCEA--------- --QSPQFLP---QCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKE QIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFV T----------------------------------------------------------- ------------------------------------------------------------ ---------------------WLQELVQTIGKVRETYYTQVS----LLDKLIGELEAKQD QPEWELMQ-DIGATLHRA--ETMTASELLGIPPGVKE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATRE GCRPSTTKAQ--ALIPTVHLKCDGAHT-----------------QDFDVILCAELEAGGS EPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFIGSALGEAH-TSIPARSSSSC SCRDW-------------------DLAAVHPSLIF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -- >C_familiaris_ENSCAFP00000003671 SK---MSSSANIYVDNGSYDKLLSYLMGLDQSQL--EEFKLCLQSPQLLLENFRKIPWAN LKA-IDPINLLCLLSEYFSEKQMWEVTLSIFE---NMNLTSLCMEIGATMNEMEQALGPQ DP-------------------------------------NQ------------------- ------------------------------------------------------------ ---------------------------------------------------EAAEMPEEE KAPLFHRRRYRERMKAKILMM-------WDNMPWPEDHIYLR-----------NVTEKEH DELKSLLYPN-RTGAQPQTIILEGIAGVGKTTLAMKAMLHWAEGFLFQQRFSYVFFISCH KVKDMKDTT--FAGLLSWDWPDSQVPIEELMSHPERLLFVIDGFEEMDMPSNLDNSPPCT DWYQQLPVNRILFYLLKKELVPMATLLITTKEYRTKDLKKLLLNPWFVQILGFTEGDREE YFIRYFGDQKKAKKVLY------------------------------------------- ---------------------------------------------WVRKNETLFYFCSAP LVCWTVCSCLKRQMVRNPHFQI-STQTTTSLYVHFFSSLFAT-AEVSLSEQNWPGQWSAL CSLAAEGMW-FRNFTFTKEDLKHKCLEAHLIGS-LLRLNILRKVNDCEECVTFTHQSFQV FLGAMFYVLWGTKGSIGGPAKH-EEMRVLLNNALVDRNFYWNQMALFFFGLLKRSLIREL EDTLCCKVGQRIMDE-LLEWAEE--------------------------LKSYDIVLNRF EFLHFFSCLYETQEENFVRQILSHLLEA------------------DINIFGNQQLQVSS FCLKHCRSLSKLRLSVT----SSILQTELTFSVETLDMSWGGDRSNCWQDICSVFC-NGH VSELDLSNSKLNTSSMKKLCYELRNPRCKLRKLT-CKSITPVKILKELVLVLHGNNRL-T HLNLSSNNLGVPVSTMIFKTLRHSACNLQYLWLESCGLTPLVCRHLFVELSRNSSVSFLS LGDNDLS--GMKGLQGPSGMSTSSLKELSLEKCNLSAAIYQDLALHVSSTQRTTRLCLGF NPLQDDGVRLLCAALTHPECALERLVLWFCQLGAPSCRYLSEA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------LLKNKSLTHL-----NLRRNKLRDEGVKFLCKA-------LSHP DCSLQNLDLS--DCSFTADGCQELANALRHNH-----------NMKILDIRNNDVQDNGV KHLCEVLQDPYCELNTLG------LEKC--------------NLTPACCQHLSSVLTSSK SLINL--NLLENDLEPSGVSILWKALKKSMCKLQKLGLKKELYDLVKVELEELQERGSFL RVKYKWDFNDLEDKWWW------------------------------------------- ------------------------------------------------------------ --