10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000223500 -------------------------------------------------------------------------MNRLF--------G--------------------------------- M_mulatta_ENSMMUP00000026530 -------------------------------------------------------------------------MNRLF--------G--------------------------------- P_pygmaeus_ENSPPYP00000021442 -------------------------------------------------------------------------MNRLF--------G--------------------------------- C_familiaris_ENSCAFP00000002699 -------------------------------------------------------------------------MNRFF--------G--------------------------------- M_musculus_ENSMUSP00000030128 -------------------------------------------------------------------------MNRFF--------G--------------------------------- R_norvegicus_ENSRNOP00000011907 -------------------------------------------------------------------------MNRFF--------G--------------------------------- O_cuniculus_ENSOCUP00000007728 -------------------------------------------------------------------------MNRFF--------G--------------------------------- M_domestica_ENSMODP00000004938 -------------------------------------------------------------------------MNRFF--------G--------------------------------- B_taurus_ENSBTAP00000016431 -------------------------------------------------------------------------MNRFF--------G--------------------------------- A_carolinensis_ENSACAP00000009586 -------------------------------------------------------------------------MNRLF--------G--------------------------------- G_gallus_ENSGALP00000021459 -------------------------------------------------------------------------MNRFF--------G--------------------------------- T_guttata_ENSTGUP00000008472 -------------------------------------------------------------------------MNRFF--------G--------------------------------- E_caballus_ENSECAP00000007753 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014308 -------------------------------------------------------------------------MNRIF--------G--------------------------------- P_troglodytes_ENSPTRP00000035664 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000022332 -------------------------------------------------------------------------MIRIF--------G--------------------------------- T_rubripes_ENSTRUP00000016981 -------------------------------------------------------------------------MNRIF--------G--------------------------------- G_aculeatus_ENSGACP00000005636 -------------------------------------------------------------------------MNRIF--------G--------------------------------- O_anatinus_ENSOANP00000005391 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022602 -------------------------------------------------------------------------MNRLF--------G--------------------------------- D_rerio_ENSDARP00000061395 -------------------------------------------------------------------------MNRIF--------G--------------------------------- T_rubripes_ENSTRUP00000028314 -------------------------------------------------------------------------MNRIF--------G--------------------------------- G_gorilla_ENSGGOP00000016137 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000056730 -------------------------------------------------------------------------MNRIF--------G--------------------------------- M_mulatta_ENSMMUP00000038110 --------------------------------------------------------------------------NSCF--------G--------------------------------- T_nigroviridis_ENSTNIP00000021817 -------------------------------------------------------------------------MNRIF--------G--------------------------------- X_tropicalis_ENSXETP00000010898 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005797-PA -------------------------------------------------------------------------MNRLF--------G--------------------------------- A_aegypti_AAEL012313-PA -------------------------------------------------------------------------MNRLF--------G--------------------------------- C_intestinalis_ENSCINP00000009854 -------------------------------------------------------------------------MNRIF--------G--------------------------------- R_norvegicus_ENSRNOP00000055831 -------------------------------------------------------------------------MNRFF--------G--------------------------------- A_gambiae_AGAP005100-PA -------------------------------------------------------------------------MNRLF--------G--------------------------------- D_melanogaster_FBpp0074964 -------------------------------------------------------------------------MNRLF--------G--------------------------------- C_elegans_F41E6.9 -------------------------------------------------------------------------MNRIF--------G--------------------------------- T_nigroviridis_ENSTNIP00000020259 -------------------------------------------------------------------------MNRIF--------G--------------------------------- S_cerevisiae_YDR486C -------------------------------------------------------------------------MNRIF--------G--------------------------------- C_intestinalis_ENSCINP00000022555 ------------------------------------------------------------------------MFKNMF--------G--------------------------------- C_intestinalis_ENSCINP00000029640 ------------------------------------------------------------------SHKRFKMFKNMF--------G--------------------------------- S_cerevisiae_YMR077C -------------------------------------------------------------------------M------------G--------------------------------- T_nigroviridis_ENSTNIP00000014973 ----------------------------------------------------------------------MSLLSKIF--------G--------------------------------- T_rubripes_ENSTRUP00000042469 ----------------LTPEWD-DDERMEFMFSAFKENRDVNTTDWDSKMAFWTALVLKSCRQRGSVYVSLQELNMIFRRKEKSPLGLPTVLQSLARCGKIQKESEFAASVDCGWLSWGV D_melanogaster_FBpp0087704 ----------------------------------------------------------------------MSFFGKMF--------G--------------------------------- T_guttata_ENSTGUP00000017567 MCSPGEAPPGPAPAGGLPPEWETDDERMAFLFSAFKQSREVNSTEWDSKMAFWVGLVLARGRRRGAVRTCLRELQNGFERRGSVPLGLGTVLRELLRRGKLQRESDFMASVDSSWISWGV O_latipes_ENSORLP00000013553 ----------------------------------------------------------------------MSKVSKLF--------SSSSKSK--------------------------- T_nigroviridis_ENSTNIP00000009347 ----------------------------------------------------------------------MSVLMKLF--------G--------------------------------- H_sapiens_ENSP00000324205 ---------------------------MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLF--------G--------------------------------- P_troglodytes_ENSPTRP00000010536 ---------------------------MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLF--------G--------------------------------- G_gorilla_ENSGGOP00000015698 ---------------------------TSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTPRGGGGRGELAMSGLGRLF--------G--------------------------------- C_elegans_R12C12.5 --------------------------------------------------------------------MPFKKMSWFFDRMHEEAHKIKEKIK--------------------------- T_rubripes_ENSTRUP00000021743 ----------------------------------------------------------------------MSKFTKLFKGSSSSSSSSSSKSR--------------------------- G_gallus_ENSGALP00000040164 MCSPGRAPPGPAPAGDLPPEWETDDE-----------XREVNSTEWHYKMAFWVGLVLARGRRRGVVRTCLRELQNGFERRGSVPLGLGTVLRELLRRGKMQRESDFMASVDSSWISWGV 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000223500 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG M_mulatta_ENSMMUP00000026530 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG P_pygmaeus_ENSPPYP00000021442 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG C_familiaris_ENSCAFP00000002699 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG M_musculus_ENSMUSP00000030128 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG R_norvegicus_ENSRNOP00000011907 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG O_cuniculus_ENSOCUP00000007728 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG M_domestica_ENSMODP00000004938 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG B_taurus_ENSBTAP00000016431 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG A_carolinensis_ENSACAP00000009586 --------------------------------------------------------------------------------------------------------KSKPKAPPPNLTDCIG G_gallus_ENSGALP00000021459 --------------------------------------------------------------------------------------------------------KAKPKAPPPSLTDCIG T_guttata_ENSTGUP00000008472 --------------------------------------------------------------------------------------------------------KAKPKEPPPSLTDCIG E_caballus_ENSECAP00000007753 ----------------------------------------------------------------------------------------------------------SPAPPPPSLTTALL O_latipes_ENSORLP00000014308 --------------------------------------------------------------------------------------------------------TGKPKAPPPNLSDCIG P_troglodytes_ENSPTRP00000035664 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000022332 --------------------------------------------------------------------------------------------------------RGKPKAPPPNLSDCIS T_rubripes_ENSTRUP00000016981 --------------------------------------------------------------------------------------------------------SSKPKGPPPNLTDCIG G_aculeatus_ENSGACP00000005636 --------------------------------------------------------------------------------------------------------RGKPKGPAPNLTDCIG O_anatinus_ENSOANP00000005391 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022602 --------------------------------------------------------------------------------------------------------RGKPKTPPPNLSDCIG D_rerio_ENSDARP00000061395 --------------------------------------------------------------------------------------------------------RGKPKGPPPNLTDCIS T_rubripes_ENSTRUP00000028314 --------------------------------------------------------------------------------------------------------RSKPNPPPPNLSDCIG G_gorilla_ENSGGOP00000016137 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000056730 --------------------------------------------------------------------------------------------------------RSK-QAASPNLSDCIG M_mulatta_ENSMMUP00000038110 --------------------------------------------------------------------------------------------------------ESEIKAPPPSLNDCIG T_nigroviridis_ENSTNIP00000021817 --------------------------------------------------------------------------------------------------------RSKPKTPPPNLSDCIG X_tropicalis_ENSXETP00000010898 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL005797-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSIDDCIK A_aegypti_AAEL012313-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSIDDCIK C_intestinalis_ENSCINP00000009854 --------------------------------------------------------------------------------------------------------SSKPKQPAPTLNDCIA R_norvegicus_ENSRNOP00000055831 --------------------------------------------------------------------------------------------------------KAKPK-PPPSLTDCIG A_gambiae_AGAP005100-PA --------------------------------------------------------------------------------------------------------KSKPKEPGPSISDCIS D_melanogaster_FBpp0074964 --------------------------------------------------------------------------------------------------------RGKPKEPGPSLNDCIA C_elegans_F41E6.9 --------------------------------------------------------------------------------------------------------TGK-KVPPPDLNNAIS T_nigroviridis_ENSTNIP00000020259 --------------------------------------------------------------------------------------------------------SSKPKAPPPNLTDCIG S_cerevisiae_YDR486C --------------------------------------------------------------------------------------------------------YGNKKSHDQLLQESNQ C_intestinalis_ENSCINP00000022555 --------------------------------------------------------------------------------------------------------GGSKGKEKVSSQEAIQ C_intestinalis_ENSCINP00000029640 --------------------------------------------------------------------------------------------------------GGSKGKEKVSSQEAIQ S_cerevisiae_YMR077C --------------------------------------------------------------------------------------------------------QKSSKVHITKTDRAIL T_nigroviridis_ENSTNIP00000014973 ---------------------------------------------------------------------------------------------------------GGKGAKAPSPQEAIQ T_rubripes_ENSTRUP00000042469 GLLLVKPLKWTFSTLLGGSRVPPEEPFVV-IELVKEKAAEVLGAYRSSDLGGSSVLSFAELSSVCSGVCADESTLCMALLQLQRDKQVTVSLHDGEKVVKFCQHGQDRVSPVSDVDVGIY D_melanogaster_FBpp0087704 ----------------------------------------------------------------------------------------------------------GKKEVAPTTGEAIQ T_guttata_ENSTGUP00000017567 GVFILKPLKWTLSSVLGDSKIPEEEEVLIYVELLQEKAEEVYRLYQSSALSSHPVVALSELRSLCAGLCPDERTFYLLLLQLQKEKRVTILEQNGEKIVKFARGLHAKVSPMNDVDIGVY O_latipes_ENSORLP00000013553 ---------------------------------------------------------------------------------------------------------HHRSKGGPSAQEAIH T_nigroviridis_ENSTNIP00000009347 --------------------------------------------------------------------------------------------------------SGGKSGKQPTPQEAIQ H_sapiens_ENSP00000324205 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ P_troglodytes_ENSPTRP00000010536 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ G_gorilla_ENSGGOP00000015698 ---------------------------------------------------------------------------------------------------------KGKKEKGPTPEEAIQ C_elegans_R12C12.5 --------------------------------------------------------------------------------------------------------EKSRKRKAPTADEAIG T_rubripes_ENSTRUP00000021743 --------------------------------------------------------------------------------------------------------HHHRSHAGPTPQEAIH G_gallus_ENSGALP00000040164 GVFILKPLKWTLSSVLGDSKVPEEEEVLIYVELLQEKAEEVYRLYQNSVLSSHPVVALSELRSLCAGVCPDERTFYLLLLQLQKEKKVTILEQNGEKIVKFARGLHAKVSPMNDVDIGVY 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000223500 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL M_mulatta_ENSMMUP00000026530 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL P_pygmaeus_ENSPPYP00000021442 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL C_familiaris_ENSCAFP00000002699 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL M_musculus_ENSMUSP00000030128 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKEVKIDQIEDLQDQL R_norvegicus_ENSRNOP00000011907 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKEVKIDQIEDLQDQL O_cuniculus_ENSOCUP00000007728 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL M_domestica_ENSMODP00000004938 TVDSRAESIDKKISRLDSELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL B_taurus_ENSBTAP00000016431 TVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL A_carolinensis_ENSACAP00000009586 TVDSRAESIDKKISRLDAELVKYKDQMKKM-----REGPAKNMVKQ-KALRVLKQKRMYENQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKVGVKEMKKAYKQVKIDHIEDLQDQL G_gallus_ENSGALP00000021459 TVDSRAESIDKKIARLDAELVKYKDQMKKM-----REGPAKNTVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQALKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL T_guttata_ENSTGUP00000008472 KVDSRAESIDKKIARLDAELVKYKDQMKKM-----REGPAKNTVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQALKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL E_caballus_ENSECAP00000007753 LVDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL O_latipes_ENSORLP00000014308 NVDSRTESVDKKIARLDAELVKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQRDNLMQQSFNMEQANYTIQTLKDTKT-TVDAMKTGLKEMKKAYKQVKIDKIEDIQDQL P_troglodytes_ENSPTRP00000035664 -VDSRAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDLQDQL O_latipes_ENSORLP00000022332 TVDARSESIEKKIGRLDAELLKYKDQLKKM-----RDGPSKNTVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL T_rubripes_ENSTRUP00000016981 TVDSRTDSIDKKISKLDAELVKYKDQMKKM-----KDGPSKNMVKQ-RAMRILKQKKAYENQRDGLAQQSFNMEQANYTIQNLKDTKT-TVDAMKTGLKEMKKAYKKVDINKIEDIQDQL G_aculeatus_ENSGACP00000005636 NVDSRSESVDKKIARLDVELVKYKDQMKKM-----RDGPSKNMVKQ-KALRVLKQKRMYEGQRDNLMQQSFNMEQTNYTIQTLKDTKT-TVDAMKIGLKDMKKAYKHVKIDQIEDLQDEL O_anatinus_ENSOANP00000005391 -VDSRAESIDKKIARLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLSQQSFNMEQANYTIQSLKDTKT-TVDAMKLGVKEMKKAYKQVKIDQIEDIQDQL G_aculeatus_ENSGACP00000022602 SVDARSESIEKKIGRLDAELVKYKDQMKKM-----REGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKRAYKDVKLDQIDDLQDQL D_rerio_ENSDARP00000061395 GVDSRAESVDKKIARLDAELMKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQRDQLMQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKNVKIDQIEDLQDQL T_rubripes_ENSTRUP00000028314 NVDARSESIEKKISRLDAELIKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL G_gorilla_ENSGGOP00000016137 -VDSXAESIDKKISRLDAELVKYKDQIKKM-----REGPAKNMVKQ-KALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKT-TXXXXXXXVKEMKKAYKQVKIDQIEDLXDQL D_rerio_ENSDARP00000056730 NVDTRIESIDKKIARIDAELMKYKDQMKKM-----RDGPSKNTVKQ-KAMRVLKQKRMYEGQRDQLSQQSFNMEQANYTIQSLRDTKT-TVEAMKIGAKEMKKAYKQVKMDQIEDLQDQL M_mulatta_ENSMMUP00000038110 MVDGRAESTDKKISRLDTELVKCKDQI-KM-----RGGPAKNTVTQ-KALRVLKQKRMYEQQQENRTQQSFNTEQVNYTIQSLKDTKT-TADAMKLGAGEMK-AYN----DQIENLQDQV T_nigroviridis_ENSTNIP00000021817 NVDARSESIEKKIARLDAELIKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYEGQREQLAQQSFNMEQANYTIQTLKDTKT-TVEAMKIGAKEMKKAYKDVKLDQIDDLQDQL X_tropicalis_ENSXETP00000010898 -VDSRSESIDKKISRLDAELVKYKDQMKKM-----REGPSKNMVKQ-KALRVLKQKRMYEQQRDNLNQQSFNMEQTNYAIQSLKDTKT-TVDAMKVGAKEMKKAYKQVKIDQIEDLQDQL A_aegypti_AAEL005797-PA GVDSRAETIDQKVRTLDAELRKYKDQMAKM-----REGPAKNAVKA-KALRVLKQRKQYENQVENLRNQSFNMEQANFAAQTLKDTHA-TVAAMKDGMKSMKKEFKKINIEEIEDIQDDM A_aegypti_AAEL012313-PA GVDSRAETIDQKVRTLDAELRKYKDQMAKM-----REGPAKNAVKA-KALRVLKQRKQYENQVENLRNQSFNMEQANFAAQTLKDTHA-TVAAMKDGMKSMKKEFKKINIEEIEDIQDDM C_intestinalis_ENSCINP00000009854 SVDDRTESVEKKISKLDAELLKYRNQMKKM-----RPGPAKKAVQN-RALRVLKQKKMYETQRDNMMSQSFNMEQTNYSIQTIKDTKN-VVGAMKVGLKEMKKEHKKINLDEIEDLQDDM R_norvegicus_ENSRNOP00000055831 TVDSRAESIDKKISLLDAELVKYKDQIKKM-----REG----------------QKRMCEQQRDNLTQQSFNTEQANYTIQSPEDTKT---DAMKLGVKGMKKAYKEVKIDQIEDLQGQL A_gambiae_AGAP005100-PA GVDARAEAIEGKIKTLDNELRKYKDQMAKM-----REGPAKNAVKQ-KAMRVLKQRKQYESQVENLRNQSFNMEQANFAHQTLKDTQA-TVSAMKDGMKSMKKEFKKINIEEIEDIQDDM D_melanogaster_FBpp0074964 GVDARATNIEEKISNLEAELRKYREQMSKM-----REGPAKNSVKQ-KALRVLKQKKAYEQQAESLRNQSFNMEQANYAAQSLKDTQA-TVAAMKDGVKQMKTEYKKINIDQIEDIQDDM C_elegans_F41E6.9 NVESRSDSIDKKIQKLDQDLMKLRDQMSKM-----REGPSKNLIKQ-KALRVLKQKRMYENQKGQLDQQAFNMDQSNFAIQGMKDNQV-TVAAMKDGLKTMQKEYKKMNIDQIEDLQDQM T_nigroviridis_ENSTNIP00000020259 NVDARSDSIDKKISKLDAELAKYKDQMKKM-----RDGPSKNMVKQ-KAMRVLKQKRMYESQRDNLMQQSFNMEQTNYTIQNLKDTKT-T------------------------------ S_cerevisiae_YDR486C SMNQAQQSLSNRISQLDTQIAQLNFQLQNIQKNLQRSNNKQPSLRK-QALKILNKRKQLENMKDSLDSQSWSMTQAQLTNDNLQNTMI-TINALKQTNNAMKAQYGKINIDKLQDMQDEM C_intestinalis_ENSCINP00000022555 KLRDTAEMLQKKSEHLEVKI---ERELKTA-----KQHGTKN--KK-MAIAALKRKKRFEKQLQNVDGTLSTVELQLEAVQNAESNKL-VLDTMKTGAQALKQAHNHMNADEVHDVMDEI C_intestinalis_ENSCINP00000029640 KLRDTAEMLQKKSEHLEVKI---ERELKTA-----KQHGTKN--KK-MAIAALKRKKRFEKQLQNVDGTLSTVELQLEAVQNAESNKL-VLDTMKTGAQALKQAHNHMNADEVHDVMDEI S_cerevisiae_YMR077C EVKRSKDEIHKFTRRTDNLILVEKSQLKDL----IRKNPENYKSNM-KVRFLLKRIHYQEHLLQQASDQLINLENMVSTLEFKMVEKQ-FINGLKNGNEILKKLNKE--FSNVDELMDDV T_nigroviridis_ENSTNIP00000014973 KLRETEEMLTKKQEFLEKKI---EQELQTA-----KKNGTKN--KR-AALQALKRKKRYEKQLAQIDGTLSTIEFQREALENANTSTE-VLKNMSFAAKALKSAHQDLDIDKVDDLMQDI T_rubripes_ENSTRUP00000042469 QLQRSEKLLGERVERLELEAHKCKEEAKML----LREGK-----KS-QALRCLRGRKRVEKRAENLLAKVESIREILDRIAQSQTDKM-VIQAYQAGVSALKLSLKDVTVERAENLVDQI D_melanogaster_FBpp0087704 KLRETENMLIKKQEFLEAKI---EDELNIA-----RKNASKN--KR-VALQALKKKKRLEKQLQQIDGTLSTIEMQREALESANTNTA-VLTTMKNAADALKRAHQNMDVDKVHDMMDDI T_guttata_ENSTGUP00000017567 QLMQSEQLLSQKVESLSQEAEKCKEDARSA----CRAGK-----KQ-LALRCLKSKRRTERRIAELHSKLDAVQGILDRIYASQTDQM-VFNAYQAGVGALKLSMKDVTVERAENLVDQI O_latipes_ENSORLP00000013553 RLRETEEMLTKKQEYLEKKI---EQEIATA-----KKHGTKN--KR-AALQALKRKKRLEQQLAQIDGTLSTIEFQREALENSHTNTE-VLKNMGFAAKAMKQVHQNMDLDKIDDLMQDI T_nigroviridis_ENSTNIP00000009347 RLRETEEMLTKKQEFLEKKI---DQELLTA-----KKNGTKN--KR-AALQALKRKKRYEQQLNQIDGTLSTIEFQREALENANTNTE-VLKNMGMAAKAMKQAHHNIGVDNIDDLMADI H_sapiens_ENSP00000324205 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI P_troglodytes_ENSPTRP00000010536 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI G_gorilla_ENSGGOP00000015698 KLKETEKILIKKQEFLEQKI---QQELQTA-----KKYGTKN--KR-AALQALRRKKRFEQQLAQTDGTLSTLEFQREAIENATTNAE-VLRTMELAAQSMKKAYQDMDIDKVDELMTDI C_elegans_R12C12.5 NLRDAEELLIKKQEYFELRI---EQEVESA-----KKYMKTN--KK-MALAALRKKKHYEQELSRIDGVLTKLEAQRTALENVGMHNE-VIDVLGKTTETLKKEHAKMDIDKVHDLMDEI T_rubripes_ENSTRUP00000021743 KLRETEEMLTKKQDFLEKRI---EQELMTA-----KKHGTKN--KQAAALRALKKKKRLEQQLVQIDGTLSTIEFQREALENSHTNTE-VLKNMGFAARALEKVHKDINIDKIDDMMQDI G_gallus_ENSGALP00000040164 QLMQSEQLLSQKVESLSQEAEKCKDDARSA----CRAGK-----KQ-LALRCLKSKRRTERRIEELHSKLDAVQGILDRIYASQTDQMVVFNAYQAGVGALKLSMKDVTVEKAENLVDQI 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000223500 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV M_mulatta_ENSMMUP00000026530 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV P_pygmaeus_ENSPPYP00000021442 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV C_familiaris_ENSCAFP00000002699 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV M_musculus_ENSMUSP00000030128 EDMMEDANEIQEALGRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV R_norvegicus_ENSRNOP00000011907 EDMMEDANEIQEALGRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV O_cuniculus_ENSOCUP00000007728 EDMMEDASEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV M_domestica_ENSMODP00000004938 EDMMEDANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PS-DAK------------------NKDGV B_taurus_ENSBTAP00000016431 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAA-----APAIPEGV----------PT-DTK------------------NKDGV A_carolinensis_ENSACAP00000009586 EDMMEDASEIQEALGRS-YGT---PEIDEDDLEA--ELEALGDEL---------LADEDSSYLDEAAS-----VPAIPEGM----------PT-EAK------------------NKDGV G_gallus_ENSGALP00000021459 EDMMEEANEVQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDNSYLDEAAS-----APAIPEGT----------PV-DTK------------------NKDGV T_guttata_ENSTGUP00000008472 EDMMEEANEVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LADEDNSYLDEAAS-----APAIPEVT----------PT-DTK------------------NKDGV E_caballus_ENSECAP00000007753 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV O_latipes_ENSORLP00000014308 EDMMEDANEIQEAMGRS-YGT---PEIDEDDLEA--ELDALGDEL---------LMDDDSSYLDEAAT-----APSIPEGN----------PG-DRT-----------------ANRDGV P_troglodytes_ENSPTRP00000035664 EDMMEDANEIQEALSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV O_latipes_ENSORLP00000022332 EDMMEEAGEVQESLSRS-YGT---PDIDEEDLEA--ELDALGDEL---------LLDEDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV T_rubripes_ENSTRUP00000016981 EDMMEDANDIQDALGRS-YGT---PDIDEADLEAGTELDALGDEL---------LFDDDSTYLDEAST-----APSIPEGI----------PG-DKS-----------------TNRDGV G_aculeatus_ENSGACP00000005636 GDMMEDANDIQEALGRS-YGT---PELDDDDLEA--ELDALGDEL---------LMDDDSSYLDEAAT-----APSIPEGM----------PG-DKS-----------------VNRDGV O_anatinus_ENSOANP00000005391 EDMMEDANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LADEDTSYLDEAAS-----APAIPEGA----------PT-DAK------------------NKDGV G_aculeatus_ENSGACP00000022602 EDMMEDAGEVQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV D_rerio_ENSDARP00000061395 EDMMEDANEVQEALSRS-YGT---PEIDEDDLEAAKELDALGDEL---------LLDDDNSYLDEASS-----APAIPEGA----------PG-DRT-----------------TNRDGV T_rubripes_ENSTRUP00000028314 EDMMDEANDVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PS-DSK-----------------TNKDGV G_gorilla_ENSGGOP00000016137 EDMMEDANEIQEAXSRS-YGT---PELDEDDLEA--ELDALGDEL---------LADEDSSYLDEAAS-----APAIPEGV----------PT-DTK------------------NKDGV D_rerio_ENSDARP00000056730 EDMMEEANEVQEALSRS-YGT---PEIDEDELEA--ELDALGDEL---------LLDDDSSYLDEASS-----APSIPEGM----------PS-DTK-----------------TNKDGV M_mulatta_ENSMMUP00000038110 VDMMEDANEIQEALSRS-YGG---PEFNEDDLEA--ELD-LGDEL---------VADKD-SYLDEAVS-----APAIPTQK----------TN------------------------DGV T_nigroviridis_ENSTNIP00000021817 EDMMDEANEVQEALSRS-YGT---PDIDEDDLEA--ELDALGDEL---------LLDDDSSYLDEASA-----APSIPEGI----------PN-DSK-----------------TNK--- X_tropicalis_ENSXETP00000010898 EDMMENANEIQEALSRS-YGT---PEIDEDDLEA--ELDALGDEL---------LLDDDTSYLDEAAS-----APAIPEGV----------PN-DSK------------------NKVGF A_aegypti_AAEL005797-PA ADMLEQADEVQEAMGRS-YGM---PEIDDDELQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APAAPDKE----------PG-ADS----------------VTNKDGI A_aegypti_AAEL012313-PA ADMLEQADEVQEAMGRS-YGM---PEIDDDELQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APAAPDKE----------PG-ADS----------------VTNKDGI C_intestinalis_ENSCINP00000009854 ADMLEMSEEIQETLGRS-YGT---PELDEDDLEA--ELDALGDDM---------FEDE---FLGDEVA-----APNAPSNA----------IG-DSV----------------PANSEGV R_norvegicus_ENSRNOP00000055831 EDMVEDANGIQEAPGRS-HGT---P-LDEDDQEA--ELMRRATSF---------WLMTTALNLDQAAS-----ALAIPEGV----------PT-DTK---------------------DK A_gambiae_AGAP005100-PA ADMLEQADEVQEAMGRT-YGM---PELDDDELQA--ELDALGDEI---------ALDDDASYLDDVVK-----APEAPDKE----------PG-ADS----------------VTNKDGI D_melanogaster_FBpp0074964 ADMFEQADEVQEALGRT-YGM---PEVDDDDLQA--ELDALGDEI---------ALDDDTSYLDDVVK-----APEAPSRE----------PG-ADS---------------IVPGKSTI C_elegans_F41E6.9 EDMLDMNNEIQEAMSRQ-YDT---PDIDEADLEA--ELAMLGDEL--------DIGESDTNYLDEALA-----APTVPSDK----------PK-TRV-------------------AEGL T_nigroviridis_ENSTNIP00000020259 ------------------------------------------------------------------------------------------------------------------------ S_cerevisiae_YDR486C LDLIEQGDELQEVLAMN-NNSGELDDISDAELDA--ELDALAQEDFTLPTSENSLGNDMPSYLLGANA-----PPAFIDEE----------PN-LDT-----------------EDKNKA C_intestinalis_ENSCINP00000022555 DEQKVISDEITTALSGG-FGY---QDVDEDDLMA--ELEELEQEE----------FNENMLDIPAAEE-----LPDVPTHS----------LP-QPA----------------------- C_intestinalis_ENSCINP00000029640 DEQKVISDEITTALSGG-FGY---QDVDEDDLMA--ELEELEQEE----------FNENMLDIPAAEE-----LPDVPTHS----------LP-QPA-----------------KAKAKA S_cerevisiae_YMR077C QDQIAYQNEINETLSRS-LVG---TSNYEDDLDK--ELDALESEL-----NPEKMNNAKVANMPSTEG-----LPSLPQGE----------QT-EQK-----------------EREEFA T_nigroviridis_ENSTNIP00000014973 -EQQELAQEISDAISKP--GLG--EQFDEDDLLA--ELDELVQVE----------LDQNLLDIEGTGNVS---LPNVPSTS----------LP-SRP-----------------AIKAKK T_rubripes_ENSTRUP00000042469 QELCDAQDDVNQTLSRG-VAG---AEGDMDELEE--ELKLLLDET----------KPDSISL-----------LPEVPSGAVKHPGGTGLLDSLPDAPHGPIGICEQLKQLSVTDAGGTG D_melanogaster_FBpp0087704 AEQQDVAREISDAISNP-VAFG--ADLDDEDLER--ELDELEQEN----------FDKEIIGIPEPTPT----LPEAPTED----------LP-EKA----------KEKKKATTTTAVE T_guttata_ENSTGUP00000017567 QELCDTQDEVAQTLAGVGING---LEVDSEELEK--ELDSLLQDS----------SKDSLD------------LPPVPQKV------PG--APISDAE-----LEAELEQLSVSAGDLAQ O_latipes_ENSORLP00000013553 TEQQEVAQEISEAISRP-FG----DTFDEDELLA--ELEELEQQE----------LEDSMKNMGG--------LPNVPNSK----------LP-ARPGPRPRSMVGLESNRFCFAATKKR T_nigroviridis_ENSTNIP00000009347 AEQHELAQEISDTISRP-VGPG--IDFDEDELLA--ELEEMEQEE----------LDKNLLEVEGPSSDP---LPNVPSTS----------LP-ARP-------------------AKKE H_sapiens_ENSP00000324205 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPSVKLPSVPSTH----------LP-AGP-------------------APKV P_troglodytes_ENSPTRP00000010536 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPPVKLPSVPSTH----------LP-AGP-------------------APKV G_gorilla_ENSGGOP00000015698 TEQQEVAQQISDAISRP-MGFG--DDVDEDELLE--ELEELEQEE----------LAQELLNVGDKEEEPPVKLPSVPSTH----------LP-AGP-------------------APKV C_elegans_R12C12.5 ADGLAMSEELNEAISAP-IG----DVADEDELMQ--ELQELQDNV---------------ADLSTTTK-----LPDVPAT-----------LP-EAP-----------SGELTRAGRRGK T_rubripes_ENSTRUP00000021743 TEQQDRAQEISDAISRP-FG----DVYDEDELLA--ELQELQDQD----------MEESMESMGG--------LPSVPSSK----------LPSARP-----------SQHAYFPATRRR G_gallus_ENSGALP00000040164 QELCDTQDEVAQTLAGAGVNG---LEMDSEELEK--ELDSLLQDS----------AKEPVH------------LHPVPQKD------SGFAGAISDAE-----LEAELEKLSVCDGDLAQ 490 =========+======= H_sapiens_ENSP00000223500 LVDEFGLPQIPAS---- M_mulatta_ENSMMUP00000026530 LVDEFGLPQIPAS---- P_pygmaeus_ENSPPYP00000021442 LVDEFGLPQIPAS---- C_familiaris_ENSCAFP00000002699 LVDEFGLPQIPAS---- M_musculus_ENSMUSP00000030128 LVDEFGLPQIPAS---- R_norvegicus_ENSRNOP00000011907 LVDEFGLPQIPAS---- O_cuniculus_ENSOCUP00000007728 LVDEFGLPQIPAS---- M_domestica_ENSMODP00000004938 LVDEFGLPQIPAT---- B_taurus_ENSBTAP00000016431 LVDEFGLPQIPAS---- A_carolinensis_ENSACAP00000009586 LVDEFGLPQIPAT---- G_gallus_ENSGALP00000021459 LVDEFGLPKIPAT---- T_guttata_ENSTGUP00000008472 LVDEFGLPKIPAT---- E_caballus_ENSECAP00000007753 LVDEFGLPQIPAS---- O_latipes_ENSORLP00000014308 LVDEFGLPQIPAT---- P_troglodytes_ENSPTRP00000035664 LVDEFGLPQIPAS---- O_latipes_ENSORLP00000022332 LVDEFGLPQIPAT---- T_rubripes_ENSTRUP00000016981 LVDEFGLPQIPAS---- G_aculeatus_ENSGACP00000005636 LVDEFGLPQIPAT---- O_anatinus_ENSOANP00000005391 LVDEFGLPQIPAT---- G_aculeatus_ENSGACP00000022602 LVDEFGLPQIPAS---- D_rerio_ENSDARP00000061395 LVDEFGLPQIPAT---- T_rubripes_ENSTRUP00000028314 LVDEFGLPQIPAS---- G_gorilla_ENSGGOP00000016137 LVDEFGLPQIPAS---- D_rerio_ENSDARP00000056730 LVDEFGLPQIPAT---- M_mulatta_ENSMMUP00000038110 LVDEFGLPQIPASYICI T_nigroviridis_ENSTNIP00000021817 ----------------- X_tropicalis_ENSXETP00000010898 L---------------- A_aegypti_AAEL005797-PA LVDEFGLPQIPTQVKST A_aegypti_AAEL012313-PA LVDEFGLPQIPTQVKST C_intestinalis_ENSCINP00000009854 PVDEFGLPQLPA----- R_norvegicus_ENSRNOP00000055831 LVDEFGLPQIPAL---- A_gambiae_AGAP005100-PA LVDEFGLPKIPASVKTT D_melanogaster_FBpp0074964 ETDEFGLPKIPTSLKTT C_elegans_F41E6.9 EVDEFGLPKLPA----- T_nigroviridis_ENSTNIP00000020259 ----------------- S_cerevisiae_YDR486C LESAQ------------ C_intestinalis_ENSCINP00000022555 ----------------- C_intestinalis_ENSCINP00000029640 KEDDDELAELQMWAS-- S_cerevisiae_YMR077C TEERSDTKEPLALLS-- T_nigroviridis_ENSTNIP00000014973 EEDEDDMEDLQRWAMEA T_rubripes_ENSTRUP00000042469 AAGLAAARQIQETSRPA D_melanogaster_FBpp0087704 DDDDPDMKQLLSWSN-- T_guttata_ENSTGUP00000017567 KTPSASSEPKTALGLNL O_latipes_ENSORLP00000013553 VEDDDDMHMLASWAT-- T_nigroviridis_ENSTNIP00000009347 EEEEDDMADLQAWAIS- H_sapiens_ENSP00000324205 DEDEEALKQLAEWVS-- P_troglodytes_ENSPTRP00000010536 DEDEEALKQLAEWVS-- G_gorilla_ENSGGOP00000015698 DEDEEALKQLAEWVS-- C_elegans_R12C12.5 FRKMSTMEELEQWAASN T_rubripes_ENSTRUP00000021743 AEEDEDLSKLASWAI-- G_gallus_ENSGALP00000040164 KTPSASSEPQTALGLNL