>H_sapiens_ENSP00000222823 --------------------------------------------MEEQGHSEMEI----- IP---------------------------------------------------------- ---------------------------------------SESHPHIQLLKSNRELLVTHI R-NTQCLVDNLLKNDYF------SAEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPW---LLEI GFSPSLLTQ---SKVVVNTDP--------VSRYTQQLRHHLGRDSKFVLCYAQKEE---- -LLLEEIYM---D------------TIM-------------ELVGFSN------ESLGSL NSLACLLDHT--------TGI--LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAG -VKFFFHFRCRMFSCF-----KESDRLCLQDLLFKHYCYPERDPE-EVFAFLL-RFPHVA LFTFDGLDELHSDL-DLSRV----PDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART GI--EVPRQFLR-KKVLLRGFSPSHLRA-YAR---RMFPE-----------------R-- -ALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRA----AFEG-SPQLPD-CTMTL TDVFLLVTEVHLNR--MQP-SSLVQRN---TRSPVETLHAGRDTLCSLGQVAHRGMEKSL FVFTQEEVQAS--------------GLQERDMQLGF--LRALPELGP----GG---DQQS YEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEW-MPPAGAA-TT-------------- -----S-CYPPFLPFQ-CL-Q----GSGPAREDLFKN----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLRHLVPA-A-AL-R-RKRKALWAHLFSSLRG YLKSLPRVQVE--SFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFP---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSRLT----------VLRLSVN--- QITD-----GGVKVLSEELT------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGARYVTKILDEC-KGLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKYLALAVKNSKS-ISEV--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLASNGISTEGGKSL---ARALQQN-TSLEILWLTQ--NELNDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGTAQLADALQ---------- ---------------------------------------------------SNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVYEDEKRII--CF----------------------------- ---------------------------------------- >P_troglodytes_ENSPTRP00000032533 --------------------------------------------MEEQGHSEMEI----- IP---------------------------------------------------------- ---------------------------------------SESHPHIQLLKSNRELLVTHI R-NTQCLVDNLLKNDYF------SAEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPW---LLEI GFSPSLLTQ---SKVVVNTDP--------VSRYTQQLRHHLGRDSKFVLCYAQKEE---- -LPLEEIYM---D------------TIM-------------ELVGFSN------ESLGSL NSLACLLDHT--------TGI--LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDTG -VKFFFHFRCRMFSCF-----KESDRLCLQDLLFKHYCYPERDPE-EVFAFLL-RFPHVA LFTFDGLDELHSDL-DLSRV----PDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART GI--EVPRQFLR-KKVLLRGFSPSHLRA-YAR---RMFPE-----------------R-- -ALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRA----AFEG-SPQLPD-CTMTL TDVFLLVTEVHLNR--MQP-SSLVQRN---TRSPVETLHAGRDTLCSLGQVAHRGMEKSL FVFTQEEVQAS--------------GLQERDMQLGF--LRALPELGP----RG---DQQS YEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEW-MPPAGAA-TT-------------- -----S-CYPPFLPFQ-CL-Q----GSGPAREDLFKN----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLRHLVPA-A-AL-R-RKRKALWAHLFSSLRG YLKSLPRVQVE--SFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFP---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSRLT----------VLRLSVN--- QITD-----SGVKVLSEELT------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGARYVTKILDEC-KGLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKYLALAVKNSKS-ISEV--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLASNGISTEGGKSL---ARALQQN-TSLEILWLTQ--NELNDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGTAQLADALQ---------- ---------------------------------------------------SNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVYEDEKRII--CF----------------------------- ---------------------------------------- >P_pygmaeus_ENSPPYP00000019815 --------------------------------------------MEERGHIEMEI----- IP---------------------------------------------------------- ---------------------------------------SESHPHIQLLKSNRELLVTHI R-NTQCLVDNLLKNDYF------SAEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPW---LLEI GFSPSLLTQ---SKVVVNTDP--------VSRYTQQLRHHLGRDSKFVLCYAQKEE---- -LLLEEIYM---D------------TIM-------------ELVGFSN------ESLGSL DSLACLLDHT--------TGI--LNEQGETIFILGDAGVGKSMLLQRLQSLWATGWLDAG -VKFFFHFRCRMFSCF-----KESDRLCLQDLLFKHYCYPERDPE-EVFAFLL-RFPHVA LFTFDGLDELHSDL-DLSRV----PDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART GV--EVPRQFLR-KKVLLRGFSPSHLRA-YAR---RMFPQ-----------------R-- -ALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRA----AFEG-SPQLPD-CTMTL TDVFLLVTEVHLNR--MQP-SSLVQRN---TRSPVETLRAGRDTLCSLGQVAHWGMEKSL FVFTQEEVQAS--------------GLQERDMQLGF--LRALPELGS----GG---DQQS YEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEW-MPPGGAA-TA-------------- -----S-CYPPFLPFQ-CL-R----GSGLAREDLFKN----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLRHLVPA-A-AL-R-RKRKALWAHLFSSLRG YLKSLPRVQVE--SFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGFCANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFP---KRLALDLDNN-NLNDYG------- ------------------------VRELR----PCFSRLT----------VLRLSVN--- QITD-----GGVKVLSEELT------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGARYVTKILDEC-KRLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKCLALAVKNSKS-ISEV--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLASNGISTEGGKSL---ARALQQN-TSLEILWLTQ--NELNDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGTAQLADALQ---------- ---------------------------------------------------SNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVYEDEKRII--CF----------------------------- ---------------------------------------- >G_gorilla_ENSGGOP00000004981 --------------------------------------------MEEQGHSEMEI----- IP---------------------------------------------------------- ---------------------------------------SESHXHIQLLKSNRELLVTHI R-NTQCLVDNLLKNDYF------SAEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPW---LLEI GFSPSLLTQ---SKVVVNTDP--------XXXXXXXXXXXXXXXXXXXXXYAQKEE---- -LLLEEIYM---D------------TIM-------------ELVGFSN------ESLGSL NSLACLLDHT--------TGI--LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDTG -VKFFFHFRCRMFSCF-----KESDRLCLQDLLFKHYCYPERDPE-EVFAFLL-RFPHVA LFTFDGLDELHSDL-DLSRV----PDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART GI--EVPRQFLR-KKVLLRGFSPSHLRA-YAR---RMFPE-----------------R-- -ALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRA----AFEG-SPQLPD-CTMTL TDVFLLVTEVHLNR--MQP-SSLVQRN---TRSPVETLHAGRDTLCSLGQVAHRGMEKSL FVFTQEEVQAS--------------GLQERDMQLGF--LRALPELGP----GG---DQQS YEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEW-MPPAGAA-TT-------------- -----S-CYPPFLPFQ-CL-Q----GSGPAREDLFKN----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLRHLVPA-A-AL-R-RKRKALWAHLFSSLRG YLKSLPRVQVE--SFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFP---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSRLT----------VLRLSVN--- QITD-----GGVKVLSEELT------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGARYVTKILDEC-KGLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKYLALAVKNSKS-ISEV--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLASNGISTEGGKSL---ARALQQN-TSLEILWLTQ--NELNDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGTAQLADALQ---------- ---------------------------------------------------SNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVYEDEKRII--CF----------------------------- ---------------------------------------- >M_mulatta_ENSMMUP00000016473 --------------------------------------------MEEQGHSEMEI----- IP---------------------------------------------------------- ---------------------------------------SESHPHIQLLKSNRELLVTCI R-NTQCLVDNLLKNDYF------STEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPW---LLEI GFSPSLLIQ---SKVVVNTDP--------VSRYTQQLQHHLGRDSKFMLCYAQKEE---- -LLLEEIYM---D------------TVM-------------ELVSFSN------ESLGSL DSLACLLDHT--------TGI--LNEQGETIFVLGDAGVGKSMLLQRLQSLWATGRLDAG -VKFFFHFRCRMFSCF-----RESDRLCLQDLLFKHYCYPEQDPE-EVFAFLL-RFPHVA LFTFDGLDELHSDL-DLSRV----PDSSCPWEPAHPLVLLANLLSGKLLKGASKLLTART GI--EVPRQFLR-KKVLLRGFSPSHLRA-YAR---KMFPE-----------------R-- -ALQDHLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRA----AFEG-SPQLPN-CMMTL TDVFLLVTEVHLNR--MQP-SSLVQRN---TRSPVETLRAGRDTLCSLGQLAHRGMERSL FVFTQEEVEAS--------------GLQEGDMQLGF--LRALPELGP----GG---DQQS YEFFHLTLQAFFTAFFLVLDDRVGTRELLRFFQEW-MPPGGAA-AA-------------- -----S-CYPPFLPFQ-CL-R----GSSPSREDLFKN----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLRHLVPA-A-AL-R-RKRKALWAHLFSSLRG YLKSLPRVQVE--SFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFP---KRLALDLDNN-NLNDYG------- ------------------------VRELR----PCFSRLT----------VIRLSVN--- QITD-----GGVKVLSEELT------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGARYVTKILDEC-KGLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKCLALAVKNSKS-ISDV--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLASNGVSTEGGKSL---ARALQQN-TSLEILWLTQ--NELDDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGTAQLADALQ---------- ---------------------------------------------------NNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVYEDEKRII--CF----------------------------- ---------------------------------------- >E_caballus_ENSECAP00000011590 --------------------------------------------MEKQGHREMGI----- IP---------------------------------------------------------- ---------------------------------------SESHSYIKLLKTNRELLVTHI R-NTQCLVDNLLKSDYF------SAEDA-EIVGACPTLPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYVLQQLADAYVDLRPW---LSEI GFSPSPLIQ---SKTVVNTDP--------VSRYTQKLRHQLGLDSRFILCYAQKEE---- -LLLEEMYT---D------------TIM-------------ELVGFRN------ESLGRL GSLACLLDHT--------TGI--LSEQGETIFVFGDAGVGKSMLLQRLQGLWATGQLDAG -FKFFFHFRCRMFSCF-----RESDVLCLQDLLFKHYCYPEQDPE-EVFAFLL-RFPHTA LFTFDGLDELHSDF-DLSSV----PDTSSPWEPAHPLVLLANLLSGKLLKGASKLLTART GI--EIPRQLLR-KKVLLLGFSPSHLRA-YAR---RMFPN-----------------R-- -AVQDRLLDQLEANPNLCSLCAVPLFCWIIFRCFQHFHS----TFDG-SLQLPD-CTVTL TDIFLLVTEVHLNR--TQP-TSLVQRN---MRSQSEAFRAGRDTLHSLGQVAHRGMEKNL FVFGQEELQAS--------------EMQEGDLQLGF--LRAVPELGL----GG---DQPS YEFFHLTLQAFFTAFFLVVDDKVGTRGLLRFFQEW-APPGEAA-AA-------------- -----S-CYPPFLPFQ-CL-G----GSGLAGEDPFKN----------------------- -------KDHFHFTNLFLCGLLSKTKQKLLRHLVPG-A-AL-R-RKRKALWGHLFASLRS YLKNLPRTQTE--GFTQVQAMPTFIWMLRCIYETQSEKVGQLAARGICANYLKLTYCN-- ------------------------------------------------------------ -----ACPADCSA----L-------SFVLHHLR---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSHLT----------IIRLSVN--- QITD-----SGVKVLHEELT------------------------------KYKIVTFLG- ------------------------------LYKNQITDVGARYIASILDEC-KGLMYLK- --LGEN-KITSEG----------------------------------------------- ---------------------------GKCLALAVKNSKS-IFEV--------------- ----------------------------------------------G--MWGNRIGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--SLAFNGISTEGGKSL---AWALQQN-TSLRIFWLTK--NELDDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGVAQLVDALQ---------- ---------------------------------------------------KNTGIMEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFEDEKRIV---F----------------------------- ---------------------------------------- >C_familiaris_ENSCAFP00000004572 --------------------------------------------MEKQSHGEMGI----- IP---------------------------------------------------------- ---------------------------------------SESHSHIKLLKINRELLVTHI R-NTQCLVDNLLENDYF------SSEDA-EIVGACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEASEFLLYVLQQLEDAYVDLRPW---LSEI GFSPSELIQ---SKVVVNTDP--------VSRYTEKLRQQLGRDSKFVLCYAQKEE---- -LLLEETYT---D------------TIA-------------ELVGLKD------ESLGPL GSLACLLDRS--------SGV--LSEQGETIFICGDAGMGKSMLLQRLQSLWAARRLDAQ -FKFFFHFRCRVFSCF-----KEGDALCLQDLLFKHYCYPEQDPD-EVFAFLL-RCPHAA LFTFDGLDELHSDF-DLSGA----PDTSSPWEPAHPLVLLANLLSGKLLKGAAKLLTART GV--EIPRQLLR-KKVLLRGFAPSHLRA-YAR---RMFPD-----------------R-- -TVQQHLLAQLEANPNLCSLCAVPLFCWIIFRCFQHFHS----VWDS-AAQLPS-RTVTL TDVFLLVTEVHLNR--TQP-TSLVQRN---TRSQVETFRASRGTLRSLGQVAHGGMEKSL FVFGQEEVQAA--------------EFQEGELQLGF--LRAVPEPGV----GG---DQQS YEFFHITLQAFFTAFFLVVDDQVGTQQLLRFFQEW-APPGEAG-AE-------------- -----S-CYPPLLPFQ-CL-K----GGGLAGEDPFKN----------------------- -------KDHFRFTNLFLCGLLSKAKEKLLRHLVPP-A-AL-R-RKRKALWAHLLASLRA HLKNLPRTQSG--GFSQVQAMPTFIWMLRCIYETQSEKVGRLAAKGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFR---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSRLT----------VLRLSVN--- QITD-----SGVKVLYEELT------------------------------KYKILTFLG- ------------------------------LYSNQITDVGARYVARILDEC-KGLTHLK- --LGEN-KITSEG----------------------------------------------- ---------------------------GKCLALAVRNSSS-ILEI--------------- ----------------------------------------------G--MWGNRIGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--SLAFNGISTEGGKSL---AQALQRN-TSLRIFWLTK--NELDDEVAESLA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGIAQLADALQ---------- ---------------------------------------------------KNTGITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFEDEKRIV--CF----------------------------- ---------------------------------------- >B_taurus_ENSBTAP00000053171 --------------------------------------------MEKHGRSKMEI----- VP---------------------------------------------------------- ---------------------------------------SESHSFIKLLKVNREHLVTHI R-NTQCLLDNLLQNDYF------SNEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RRILDLVQSKGEEVSEFFLHVIQQLADAYVDLRPW---LSEI GFSPSPLIQ---SKAVVNTDP--------VSGYSQKLQQQLGRDSKFILCYAQKEE---- -LLLEQMYT---D------------TVV-------------ELVNFSN------ESLGSL DSLACLLDAS--------TGV--LNEQGEIIFVFGDAGMGKSMLLQRLQSLWAAGQLDPG -IKFFFHFRCRTLSCF-----KKSAALCLQDLLFKHYCYPEQDPG-EVFAFLL-RFPHTA LFTFDGLDELHSDF-DLSSE----PDTSSPWEPAHPLALLASLLSGKLLKGARKLLTART GV--EVPRHLLW-KKVLLRGFSPSHLRA-YTG---RMFPE-----------------H-- -AVRQRLLDQLEANPNLCSLCAVPLFCWIIFRCFQHFHD----AFES-SPQLPD-LTVTL TDIFLLVTEVHLNR--TQP-TSLVQQN---TRSQTETLRAGRDTLCSLGRVAHRGMEKSL FVFNQDEVQAS--------------EVREGDLQLGF--LRTMPELGL----GG---EQQS YEFFHLTLQAFFAALFLVVDDKVGTRELLRFFQEW-TPPEEAV-AT-------------- -----STCYPPFLPVH-CL-G----GHDLHGEDPFKN----------------------- -------KDHFHFTNLFLCGLLSKGKQKLLQHLVPT-A-AL-R-RKRKALWTHLFASLRS HLKSLPRVQSG--GFNQVQALPTFIWMLRCIYETQSEKVGQLAARGICANYLKLTFCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHLR---KRLALDLDNN-NLNDFG------- ------------------------VRELQ----PCFSRLT----------VIRLSVN--- QITD-----SGVKVLYEELT------------------------------KYKILTFLG- ------------------------------LYNNQITDVGARYIARILDEC-KGLTHLK- --LGKN-KITSEG----------------------------------------------- ---------------------------GKSLALAVKNSKS-IFEV--------------- ----------------------------------------------G--MWGNQIGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--SLAFNGISTEGGKSL---AWALQQN-ASLRIFWLTK--NELDDEVAESFA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNQITAKGIAQLAEALQ---------- ---------------------------------------------------KNTGIMEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFEDEKRII--CF----------------------------- ---------------------------------------- >R_norvegicus_ENSRNOP00000014324 --------------------------------------------MEKRGQHEMEG----- VP---------------------------------------------------------- ---------------------------------------AGCHSHIKLLRINREHLVTNI R-NTQCLVDNLLENGYF------SAEDA-EIVCACPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLW---LSEI GFSPSQLIR---TKTIVNTDP--------VSRYTQQLRHQLGRDSKFMLCYAQKED---- -LLLEETYM---D------------TLM-------------ELVGFNN------ENLGSL GGLDCLLDHS--------TGV--LNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASK -AKFFFHFRCRMFSCF-----KESDTLTLQDLLFKHFCYPEQDPE-EVFSFLL-RFPHTA LFTFDGLDELHSDF-DMSRV----PDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTART GV--EVPRQLLR-KKVLLRGFSPSHLRA-YAR---RMFPE-----------------R-- -TAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHT----AFEG-SSQLPD-CAVTL TDVFLLVTEVHLNR--TQP-ISLMQRN---TRSPAETLRAGWRTLQALGEVAHRGTDRSL FVFGQEEVQAS--------------KLQEGDLQLGF--LRALPDVGP----EQ---SQQS YEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREW-TSPGEAT-SR-------------- -----S-CYPSFFSFQ-CL-G----SGSRLGPDPFKN----------------------- -------KDHFQFTNLFLCGLLAKARQKLLQQLVPK-A-IL-R-KKRKALWAHLFASLRS YLKSLPRVQSD--GFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFH---RQLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSRLT----------VIRLSVN--- QITD-----MGVKVLCEELT------------------------------KYKIVTFLG- ------------------------------LYNNQITDIGARYVAQILDEC-RGLTHLK- --LGKN-RITSEG----------------------------------------------- ---------------------------GRCVAQAVKNSTS-IVEV--------------- ----------------------------------------------G--MWGNQIGDEGA KAFAEALRDHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLAFNGISPEGGKSL---AQALKQN-TTLTIIWLTK--NELNDEAAECFA EMLRV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLKHL--WLIQNHITAEGTAQLARALQ---------- ---------------------------------------------------KNTTITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFENEKRII--CF----------------------------- ---------------------------------------- >M_musculus_ENSMUSP00000055747 --------------------------------------------MEEHGHHEMEG----- TP---------------------------------------------------------- ---------------------------------------LGCHSHIKLLKINREHLVTNI R-NTQCLVDNLLENGYF------SAEDA-EIVCACPTKPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLW---LSEI GFSPSQLIR---TKTIVNTDP--------VSRYTQQLRHQLGRDSKFMLCYAQKED---- -LLLEETYM---D------------TLM-------------ELVGFNN------ENLGSL GGLDCLLDHS--------TGV--LNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLTST -AKFFFHFRCRMFSCF-----KESDMLSLQDLLFKHFCYPEQDPE-EVFSFLL-RFPHTA LFTFDGLDELHSDF-DLSRV----PDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTART GV--EVPRQLLR-KKVLLRGFSPSHLRA-YAR---RMFPE-----------------R-- -TAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFQT----VFEGSSSQLPD-CAVTL TDVFLLVTEVHLNR--PQP-SSLVQRN---TRSPAETLRAGWRTLHALGEVAHRGTDKSL FVFGQEEVQAS--------------KLQEGDLQLGF--LRALPDVGP----EQ---G-QS YEFFHLTLQAFFTAFFLVADDKVSTRELLRFFREW-TSPGEAT-SS-------------- -----S-CHSSFFSFQ-CL-G----GRSRLGPDPFRN----------------------- -------KDHFQFTNLFLCGLLAKARQKLLRQLVPK-A-IL-R-RKRKALWAHLFASLRS YLKSLPRVQSG--GFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHFH---RQLALDLDNN-NLNDYG------- ------------------------VQELQ----PCFSRLT----------VIRLSVN--- QITD-----TGVKVLCEELT------------------------------KYKIVTFLG- ------------------------------LYNNQITDIGARYVAQILDEC-RGLKHLK- --LGKN-RITSEG----------------------------------------------- ---------------------------GKCVALAVKNSTS-IVDV--------------- ----------------------------------------------G--MWGNQIGDEGA KAFAEALKDHP------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLAFNGISPEGGKSL---AQALKQN-TTLTVIWLTK--NELNDESAECFA EMLRV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLRHL--WLIQNRITAKGTAQLARALQ---------- ---------------------------------------------------KNTAITEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFENEKRII--CF----------------------------- ---------------------------------------- >O_anatinus_ENSOANP00000017157 --------------------------------------------MENRACCEAEL----- IP---------------------------------------------------------- ---------------------------------------QSPRSFIKLLKVNRELLVTQI R-NTQCLLDNLIENEYF------STEDA-EIAAASPTQPD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEYLIYVLQQVSDAYIDLKPW---LSEI CFSPSELIE---SKVVVNTDPAHFSLPTQVSRYTQKLRCELGRDSKFIMSYAQKEE---- -MLLEDTYT---E------------NVM-------------ELINFSN------ESLGSV GDLASLLDST--------TGV--INEDGETVFVFGDAGVGKSILLQKMQHLWAKGELGGE -AKFFFRFRCRMFSLF-----KESEVLCLKDLLFKHNCYPEQDPE-EVFAFLL-RFPHTA LFTFDGFDELHSDF-DPGAV----PEASSPVEPTHPLVLLVNLLSGKLLKGAGKVLTARA GT--EVPRRLIR-KKVLLRGFAPSHLRA-YTQ---RFFPD-----------------R-- -ALRAQVQTQLEANPNLSSLCSVPLFCWIIFKCFEHFHA----AYDS-PQGLPD-CSVTL TDVFLLVTEVHLNR--ALP-ASLLRRN---TRSQVQTLCAGRAALQALGRVAYSGLERSL FVFDQEEVEAL--------------EVPEEDLQLGF--VRAVPEAG----------DRLS YEFFHITLQSFFTALFLVVDDRVGSGELLRFFGEW-RTGGPAG-PA-------------- -----C-PRLPFLSLR-CL-A----GGGPSGEDPFRN----------------------- -------NDHFHFTNLFLCGLLSKAKQKLLRHLAPA-S-AL-K-KKRKALRAHLFSSMRA YLKSLPRCQTE--MFNQVQAMPTFIWMLRCIYETQSDKVGQLAARGICANYIKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----I-------SFVMHHFH---KRLALDLDNN-NLNDYG------- ------------------------VKELR----PCFSRLT----------VLRLSVN--- QITD-----TGVKVLYEELT------------------------------KYKIVTFLG- ------------------------------LYNNQITDVGAKYLARLMDEC-SSLTHLK- --LGAN-KITSEG----------------------------------------------- ---------------------------GKCLALAVQKSKS-IFEI--------------- ----------------------------------------------G--MWGNKIGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--SLAFNGISTEGGKSI---AQALQHN-TSVRIFWLTK--NELDDEVAESFA EMLEV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLTHL--WLIQNQITARGTTCLAGALQ---------- ---------------------------------------------------KNTGILEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-ISP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKTFEDEKRIV--CF----------------------------- ---------------------------------------- >O_cuniculus_ENSOCUP00000004572 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------V-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEFFLYILQQLTDAYVDLRPW---LSDV GFIPSPLIQ---SKAIVNTDP--------VSRYTQKLRHQLGCDSKFMLCYSKKEE---- -MLLEETYT---D------------TIM-------------ELISFNN------ESLGSL GSPACLLDQS--------AGV--LNEQAETVFVFGDAGVGKSMLLQRLQSLWASGRLDAG -VKFFFHFRCRMFSCF-----KESATLCLQDLLFKHCCYPEQDPD-EVFAFLL-RFPHTA LFTFDGLDELHSDF-DLSRV----PDSCCPWEPAHPLVLLASLLSGKLLKGASKLLTART GV--EVPRQLLR-KKVLLRGFSPSHLRT-YAH---RMFPE-----------------R-- -AARERLLEQLEANPNLCSLCAVPLFCWIIFRCFQHFHT----TLDG-SSQLPD-CTVTL TDVFLLVTEVHLNR--TQP-SSLVQRN---TRSPEETFQAGRGSLLALGRAAYGAMAKSL FVFSQEQVQAC--------------GVQEEDLQLGF--LRAVPELGS----EG---GQQS YEFFHITLQAFFTAFFLVVDDEVGTPELLAFFHEW-VPPGEVA-AA-------------- -----S-CYPRFLPFW-RV-G----GSGPVRADPFKK----------------------- -------KDHFQFTNLFLCGLLSKAKQKLLQHLVPL-A-SL-R-RKRKALWAHLFASLRT YLKNLPRVQSG--GFNQVQAMPTFLWMLRCIYETQSRKVGQLAAGGICANYLKLTYCN-- ------------------------------------------------------------ -----ACSADCSA----L-------SFVLHHSR---KRLALDLDNN-NLNDYG------- ------------------------VRELQ----PCFSCLT----------VVRLSVN--- QITD-----SGVKVLCEELT------------------------------KYKILTYLG- ------------------------------XXXXXXXXXXXXXXXXXXXXX-XXXXXXX- --XXXX-XXXXXX----------------------------------------------- ---------------------------XXXXXXXXXXXXX-XXXX--------------- ----------------------------------------------X--MWGNQIGDEGA KAFAEALRNHT------------------------------------------------- ------------------------------------------------------------ -SL--RNL--SLAFNGITSEGGRSL---AQALHCN-TSLQIF------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_domestica_ENSMODP00000019080 ------------------------------------------LAMESRVLPDGKA----- ------------------------------------------------------------ ---------------------------------------PGPPSFMKLLKVDRELLVTHI R-NVQCLLDNLMANDYF------SMEDA-EIVGACPTPPD----------KV-------- ------------------------------------------------------------ ------------------RKMLDLVQSKGEEVCEYLLHVLQQIPDAFVDLKPW---LAER GFWPSELVR---SRVVVNTDP--------VSRYTQKMRLEWGRDSKFIKSYTQREE---- -MLLADTYT---E------------HIM-------------ELVDFHD------AALGGV SSLDSLLVDS--------TGV--INVDGETVFVVGDAGVGKSVLLQQLQNSWASSEPGAG -PRFFFPFRCRTFGCF-----PPAAALSLRELLFSHSCCPELEPD-AVFEFLL-RFPATA LFTFDGLDELQSDL-DLSRL----PDVASPLQPAPPVALLASLLRGKLLPGAGKVLTART GV--ELPRALVR-KKVRLRGFGPEQLRA-YTR---KVFPE-----------------L-- -AEQQRVLSQLDASPQLSSLCSVPLFCWIIFRCLRGGPG---------PQLATE-LPLTL TDVFLLLAEAHVSR--TMP-SSPLRSDP--QHSQAETFHTGRGPLCALGRLAYWGLARNR FVFGPEQVAAS--------------QLPEGALQLGF--LRLVPEPGP----LG---PQAA YEFLHLTLQAFFAALFLVADDSVGTAKLLRFFGEG-TARRGL------------------ ------------RGLG-CL-G----GCHGGKKDPFRN----------------------- -------NDHCQFTNLFLCGLLSKAKQELVQHLVPP-A-TL-R-RKRRALWSHLAASLRS YLKGLPRTQAG--EFLQVQAMPTFIWMLRYIYEAQSQRVSRLAARGICANYLKLAYCN-- ------------------------------------------------------------ -----TCSADCSA----L-------AFVLHHVP---KQLALDLDNN-NLCDYG------- ------------------------VKELR----PCFGRLT----------VIRLSVN--- RIAD-----AGARVLSEELT------------------------------KYKIVTFLG- ------------------------------LYNNQITDVGATYVAKILEEC-PGLTHLK- --IGAN-LLTSEG----------------------------------------------- ---------------------------GKCLAAALKKSRS-ILDI--------------- ----------------------------------------------G--MWGNKIGDEGA KAFADALRDHP------------------------------------------------- ------------------------------------------------------------ -SL--ATL--SLAFNGISTEGGKSL---AQALQQN-SSMKIFWLTK--NNLDDEAAESLA EMLEV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLNDL--WLIQNQITAKGLSRLADALQ---------- ---------------------------------------------------KNSSILDIC ------------------------------------------------------------ ---------------------------------------------LSGNP-IKP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKVFQHDKRFH---F----------------------------- ---------------------------------------- >G_gallus_ENSGALP00000018785 --------------------------------------------MEGHLCANLKTSVEKP LT---------------------------------------------------------- ---------------------------------------TSPPSCIALLKVYRELLVSKI R-HTQCLIDNLINNEYF------STEDA-EIVVQFPTQAD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEVSEYFICVLQKVTDAYYELQPW---LDEI GYQPSENIC---SKPVVNTDP--------VSRYCQKLRYELGRDSKFVLSYAQREE---- -MLLEEIYS---N------------SIM-------------EMVNFTN------ESLGEV CQLQALFDDA--------VGV--INEDGETIYVFGDAGIGKSILLQKIQSLWAKKQLDIG -AKFFFHFRCRMFSCF-----KEDEAVCLKDLLFRYNCYPDQDPT-EVFHHIL-QFPHTV LFTFDGFDEIYSNF-DLSSV----PEMCSPDEPMHPLVLLVSLLRGKLLKGSKKILTART GT--EIQRNIIR-KKVLLRGFSNSNLKE-YTA---MFFKD-----------------V-- -GQRTLVLNQLEANPNLCSLCSVPLFCWIIFKCYEHFHS----MFD--SHELPD-CSVTL TDVFLLMIEVHLNR--SLK-TSLLKNN---TRSQAEVFRSRKETLLALGKIAYRGMGNSI FIFEQEEVSSA--------------NISEEDLQLGF--LRTVKGYSR----CD---NQST YEFLHLTLQSFFTALFLVIEERVGNKELLQFFNEC-SSAEAAQ-RT-------------- -----C------FRVP-WL------KKPLTGEDPFRN----------------------- -------NEHFHFTNLFLCGLLSRSKEKLFKHLVSP-A-VI-R-KKRKTLITYLGESMKS HLKGVTRSRLP--MYNQVQVQPNFVWMLRCLYETQSEKVGKLAAKRMHANYIKLTYCN-- ------------------------------------------------------------ -----AYSADCSA----I-------SFVVHHFQ---KHLALDLDNN-NINDYG------- ------------------------VKQLL----PCFSKLA----------VIRLSVN--- QITD-----HGARILYEELS------------------------------KYQIVSYLG- ------------------------------LYNNQITDIGAKYVAKLIEEC-SSLEYVK- --IGAN-KITSEG----------------------------------------------- ---------------------------GKCLAQAIQKSTT-MFEI--------------- ----------------------------------------------G--MWGNQVGDEGA KAFADALRNHP------------------------------------------------- ------------------------------------------------------------ -RL--TNV--SLAFNGITTEGGKSI---AEALQHN-DSVKIFWLTK--NELDDEAAMSFA EMLKI-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KKLVHL--WLIQNQITAKGVKYLSEALK---------- ---------------------------------------------------ENTAIKEVC ------------------------------------------------------------ ---------------------------------------------LNGNL-ISQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKAFESEERII--CF----------------------------- ---------------------------------------- >T_guttata_ENSTGUP00000004043 --------------------------------------------MEGQLCANVDISVNKP PG---------------------------------------------------------- ---------------------------------------ASPQSFIALLKVHRELLVSRI R-NTQCLIDNLIKNGYF------STEDA-EIVVQFPTQAD----------KV-------- ------------------------------------------------------------ ------------------RKILDLVQSKGEEISEYFIYVLQKVTDAYYELQPW---LDEI GYKPSENIC---SKPVVNTDP--------VSRYCQKLRHELGRDSKFFMLYAQKEE---- -MLLEEIYS---N------------SIM-------------ELVSFTN------ESLGQV GQLEALFDDA--------VGL--INEDGETVYVYGDAGIGKSILLQKIQSLWARKELDIG -AKFFFRFRCRMFSCF-----KEDEAICLKDLLFKYNCYPDQDPT-EVFHHIL-QFPHTV LFTFDGFDEIYSNF-DLSSV----PEICSPNEPIHPLALLVSLLRGKLLKGSKKILTART GT--EIQKNIIR-KKVLLRGFSRSNLKE-YTA---MFFKD-----------------E-- -QRRVLVSNQLEANPNLCSLCSVPLFCWIIFKCFEHFHS----MFD--SHELPD-SSVTL TDVFLLMIEVHLNR--SVK-TSLLKSN---IRSQAEMFKSRKESLLALGKMAYKGMENSS FIFEQEEVSSA--------------NISEEDLQLGF--LRTVKGYSG----CG---SQAT YEFLHLTLQSFFTALFLVMEEKVGTKELLEFFNEC-SSLETAQ-PT-------------- -----C------LRIP-WL------KKQLAGEDPFQN----------------------- -------KEHFNFTNMFLCGLLSGSRQKLFRHLVSP-A-VI-K-RKRKILITYLGESMKS HLKGYTRSRLK--SYNQVQMQPNFVWMLRCLYETQSEKVGRMAARRMHANYIKLAYCN-- ------------------------------------------------------------ -----ACSADCSA----I-------SFVLHHFQ---KRLALDLDNN-NINDYG------- ------------------------IKQLQ----PCFSKLA----------VIRLSVN--- QITD-----HGVRILYEELS------------------------------KYQIVSFLG- ------------------------------LYNNQITDVGAKYVAKLIEEC-SSLEYVK- --IGAN-KITSEG----------------------------------------------- ---------------------------GKCLAQAIQKSKT-MFEI--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -KL--TNV--SLAFNGITTEGGKSI---AEAMQHN-NSVRIFWLTK--NELDDEAAMSFA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KKLVHL--WLIQNKITAKGVKCLSDALQ---------- ---------------------------------------------------ENTTIKEIC ------------------------------------------------------------ ---------------------------------------------LNGNL-ISQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKAFENEERII--CF----------------------------- ---------------------------------------- >A_carolinensis_ENSACAP00000002867 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SFVSLLKVHRELLVSKV R-NTQCLIDNLLKNEYF------STEDA-EIAAQYPTQAD----------KV-------- ------------------------------------------------------------ ------------------RKILDLAQSKGEEVAEYCIYVLQQVADAYYELHPW---LEEI GFHPSEVIS---SKPVENTDP--------VSRYHQKLKDELGRDTKFIVSYTQKED---- -MLLEETYS---A------------NIM-------------EFIKHNN------EKFGDV NALEDLLSDN--------VGL--VNENGETVYIFGDAGIGKSMLLQKMQNLWSKGEFSVG -AKFFFRFRCRTFSCF-----KHDAAICLKDLLFKYNCFPDQDPE-EVFDFIV-KFPHTV LFTFDGFDEIHSDF-DLNSI----PETCSPSEYIHPLALLVGLLTGKLLKGSRKVLTART GT--EIDKNIIR-KKVHLLGFSTSNLKE-YTR---MFFKD-----------------E-- -GCRTMVLNELEANPNLCSLCSVPLFCWIIFKCFDHFHF----TFD--SHELPD-IKVTL TDIFLLMTEVHLNR--TQK-TNLLKKN---TRSQVETYRNSKNILFALSKLAHRGMKKSI FVFDQDEVLN---------------DLSEQDLHLGF--LRTVPDYGS----CT---DQPS YEFLHLTLQSFFTALFLVMEEKVGAKELLHFFAEC-STLDTSL-SN-------------- -----C------LPIA-WL-K----NHRATGEDPFRN----------------------- -------KEHFHFTNLFLCGLLSKGQHKLMRHLVPS-L-TI-K-KKRKVLLAYFSGSMKS HLKGLIRARLK--EYKQLQVRPNFVWMLRCIYETQSEKVSKGVAKNMRANYLKLTYCN-- ------------------------------------------------------------ -----VYSADCSA----L-------SFILHHFQ---KHLALDLDNN-NINDYG------- ------------------------IKQLF----PCFSKLT----------VLRVSVN--- QITD-----QAIRVLYEELS------------------------------KYKIVTYLG- ------------------------------LYNNQITDVGAKYVAKLIVEC-PSLIYIK- --IGAN-KITTEG----------------------------------------------- ---------------------------GKSLAYAIQQSKT-MYEI--------------- ----------------------------------------------G--MWGNQVGDEGA KAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -TL--TNI--SLAFNGITTEGGKCL---AEAMKHN-NTVNIFWLTK--NDFDDEAAECFA EMLKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KRLGHL--WLIQNQITARGAKCLADALH---------- ---------------------------------------------------DNTAIKEVC ------------------------------------------------------------ ---------------------------------------------LNGNP-ISQ------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAKAFENEKRLI--CF----------------------------- ---------------------------------------- >X_tropicalis_ENSXETP00000047642 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SHVHSIRTSREELVNKI K-NTNCLLENLTEHGFF------STEDA-EIVMQFSTKSD----------RV-------- ------------------------------------------------------------ ------------------RQILDLVESKGEEVSEYFLSVLQRIPEAYFNLKPW---LEEI CFQASEQIL---CLNVKNNDP--------VTVFSRKIKHELCCDVKYIKSYTEREE---- -MMLQETYV---N------------GIM-------------ELISAAN------ENMGRV QDLSCLFD-G--------NGV--INEDGETIFVFGDAGMGKTLLIQKLQNMWAKGEYYCE -IKFLFRFRCRTFSLF-----KKTTLITLEDLLFKYNCNPDHEPE-EVYRYIL-HFPETV LFTFDGFDEIHSDF-DLNSV----PEVSSPFTQTHPVVLLSHLLSGKLLKGSKKVLTART AT--HVPKNIIR-KKIMLRGFSTENLHA-YTS---LFFKE-----------------S-- -EIHKRVISHLKANHNFSSLCSIPLFCWIIFKSYEHFHS----IND--CQEFSS-SSVTL TDIFLLISEVYLNM--SSK-VFSVKGA---SRSQSETFKNGKDTLLSIGRLAYDGMERSM FVFDQDAVTSL--------------NISEKDLKLGF--LRTVKVYSE----LG---DHTS FEFFHMTLQSFFTALFLVINDKTGSAELLKYFSQC-TYTEDKE-LQ-------------- -----H------SPLS-CI-C----ARRDRKEDPFKN----------------------- -------NDHLQFINLFLCGLLSKPKQSLLKDIVPP-S-IL-K-MKRKALKQKLYKSVKS HLKSLPRSPFL--EYNRVHALTHFIWMARCICETQSEKVGKLAAKGICADYIKLSFCG-- ------------------------------------------------------------ -----ASSSDCGA----I-------SFVLNHYH---KKIALELDNN-NINDYG------- ------------------------VKELI----PCFSKLT----------VIRLSVN--- QITD-----EGAKVLYEELT------------------------------KYKVITFLG- ------------------------------LYKNLITDFGAQFIARIIEEC-PKLKRVK- --LGYN-RFTGEG----------------------------------------------- ---------------------------GTYIGRAILNSTS-ICDI--------------- ----------------------------------------------G--MWGNEIGDVGA CAFAEAITNHS------------------------------------------------- ------------------------------------------------------------ -SL--THL--SLACNGISTEGGKSI---AEALQQN-TSLKILWLTE--NKLTDEAAEHFA KMVKV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KTLRHL--WLVNNQITNHGAELLSEALQ---------- ---------------------------------------------------HNTVMEEI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >G_aculeatus_ENSGACP00000005947 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LHQQGSVNMGEMEGTKVPYLKILTYHRELLVSQL R-SIQCILDNLLACSFV------CEEDV-EIVLRSATRTD----------QV-------- ------------------------------------------------------------ ------------------RKILELVQCKGEEACEYFIYVIYKVRDAYVDLQPW---LKEI NYSPSSDAT---ALSVVNTDP--------ISRYSEKLRHEMSRDTCFIMSYGQREE---- -TRLEDLYT---D------------TQM-------------ALLDDCN------EHLGFL GSLDELFA-D--------QAV--FNPQGEIIYVIGDAGVGKSILLQRLQNLWSKKDLQAD -AIFFFKFRCRMFSLF-----KDTDQISLRDLLFKYNCFPDHDPNNEVFDYIL-RFPEKV LFTFDGYDEIQMN--DLLNA----PEVVSPDAKAHPVQLLDSLLGGKLLKGSQKVLTART GT--EIQSTVIR-KKVVLRGFSPAHLKT-YIS---IHFKE-----------------Q-- -EHRDQVSVQLDASPHLCGLCSTPLFCWIVLKSFRHLHT----MHD--SFHLPE-TCVTL TDIFLLLCEVCLSRSGSSA-PSLLKKS---PRCVSETFVAGLRPLAAFAKVALRGMERSS FVYSQEELMEC--------------GLTEEDLTLGF--LRPVGECDA----SG---GPAT FEILHIILHSFLAAFALVLDEQAAAGSVLKFFTEC-RRKREAR----------------- -----C------APCLSCFCG----SSKSGEKTLFET----------------------- -------NEHFQFTNLFLCGLLSKAHAGLMEHLVSP-V-LL-R-KKRALLKSYLSTSVKS HLVGLPHHNSG--EGQKVHVLPNFLWMLRCIFETGSRDIAQMTAKGITAGFIKLGYCN-- ------------------------------------------------------------ -----VFSGDCTA----L-------NFVLQHRQ---KLLGLDMDNN-NISDYG------- ------------------------VKQLR----PSFCKMT----------IVRLCVN--- HLSD-----SSVEVLAEELC------------------------------KHKVVEVLG- ------------------------------LYNNYITDAGAKLVAQIIEEC-PKLRVVK- --IGKN-KITAVG----------------------------------------------- ---------------------------GRYLASAIQKSAS-IFDV--------------- ----------------------------------------------G--MWGNSIGDEGA QAFAEALRNHP------------------------------------------------- ------------------------------------------------------------ -RL--TNL--SLAANGITSKGGRCL---AEALKEN-SVLRIFWLVQ--NELNDDAAPHLA ELVQA-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TGLSHL--WLINNQFTVDGIKILSAALN---------- ---------------------------------------------------VNTALKEIC ------------------------------------------------------------ ---------------------------------------------LKANR-LSE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEEKQFVGDKRLR--FH----------------------------- ---------------------------------------- >O_latipes_ENSORLP00000004745 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SGPCLPLLTYHRELLVSTL T-SIQCLLDNLLLNGFF------CQEDV-EIVQRIPTKPD----------KV-------- ------------------------------------------------------------ ------------------RKVLELVQCKGEEACEFFIYIISKVCDAYRDLQPW---LEEI NFHPRGSVI---GMEVVNSDP--------ISRYSQKLRYEISRDTSFIMSYGQQEE---- -TQLEDLYT---D------------TVM-------------ELLNDTN------ENLGFL DNLDQLLG-D--------DAV--FNPQGEVIYVMGDAGVGKSILLQKLANLWSKKELKTD -ALFFFKFRCRMFNIF-----KDAEQISLRNLLFKYNCYPDHDPDNEVFDYIL-RFPEKV VFTFDGYDEIQEDV-DIVKF----PEVVSPEDKANALQLLMSLLSGKLLKGSKKVMTART GI--EIQSRVLR-KKVALRGFSPDHLKA-YID---LHFKE-----------------Q-- -EHRELVSVQLDASPHLCGLCSTPLFCWIVFKSFRHLQT----MHD--DFHLPD-TCITL TNIFLLLCEVFLSRLASPA-ASSLRKG---TRCTSETFRAGLRPLTAFSRLALQGLERRS LICSQEEISEC--------------GLTEEDLALGF--LKPVSDYDP----GR---GPGS FEFIHTTLQSFLAAFALVLEEQAPTGTILKFFSEC-SWRQEPS----------------- -----C------LPFTFCIGR----PVNLSLSKPFST----------------------- -------NEHFLFTNLFLCGLLAKSQLGLMGHLVCS-N-LL-R-KKRATLKSYLSTVVRS HMKGLPTYKGD--DGTKVHVLPNFLWMVRCIFETGSKQIAQMTAKGITPYFIKLGYCN-- ------------------------------------------------------------ -----VYSGDCTA----L-------NFVLQHHR---TLLRLDMDNN-NISDYG------- ------------------------VKQLR----PSFSRMT----------VVRLSVN--- SLSD-----SSIEILAEELC------------------------------KHKIVQILG- ------------------------------LYNNNITDVGAKLVAHIIEEC-PKLAVLK- --LGKN-KITGVG----------------------------------------------- ---------------------------GRYLALAIQKSTS-IFDV--------------- ----------------------------------------------G--MWGNSIGDEGA EAFAKALRNHP------------------------------------------------- ------------------------------------------------------------ -TL--TNL--SLAANGITSRGGRIL---AEGLREN-SVLRIFWLVE--NKLGDDAAPTLA ELVRA-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TGLSHL--WLINNMLTVVGIRRLAEALA---------- ---------------------------------------------------VNTKFKEIC ------------------------------------------------------------ ---------------------------------------------VKGNQ-ISK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEEKEFLLERRLR--FH----------------------------- ---------------------------------------- >T_rubripes_ENSTRUP00000035922 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MSQTGEAKMSYVDLLTVHRELLVSTL K-SVQCLLDNLSACGFF------CEEDV-DIVQQTVTRTE----------KV-------- ------------------------------------------------------------ ------------------RKILEVVQCKGEQACEYFLKVIFTVRDAYIDLQPW---LKDI NYAPSCEVT---PMPVVNTDP------RQVSRYCEKLRDDMIRDTSFIMSYGQREE---- -AHLEELYT---D------------TLM-------------ELLNDSN------ERLGFL ESLDHLLG-D--------HGV--FNPHGETIYIMGDAGVGKSLLLQKLQNLWSKKELQTD -AIFFFKFRCRMFNCF-----KDKEQISLRELLFKYNCYPDHDPDNEVFDYIL-RFPEKV IFTFDGYDEVQEDA-DQMNA----PEVASPEDKAYPLQLLMGLLCGKLLKGSQKVVTART GI--DFRQRVVR-KKVALRGFSPAHLKT-YIS---LHFKE-----------------Q-- -EHRELVSVQLDASPHLWSLCSTPLFCWITFKSFRHLHN----VHD--SFHLPD-TCVTL TGMFLMLSEVFLSHAASST-PSLLKNN---ARCTSETFRCGLRTLTAFAKLAIQGVERDG FIFSQEEVSGC--------------GLTEEELSLGF--LRAAGSCD----------GSPM FEFLHATLQSFLAAFALVLNEEAPPSSILRFFTES-RRRASS------------------ -----C------QPFRCCIQD----SSKVITKASSSA----------------------- -------NEHLQFTNLFLCGLLAKANMGLIDLLASP-N-IL-K-KKRSVLKSYLSASVRS HLQDVPQYKSS--EGSKIHGLSRLLWLLRCIFETGSKEIAQRTARGIPAGLLKLAYLN-- ------------------------------------------------------------ -----MFSSDCTA----V-------SFVLQHQP---KLYGLDMDNN-NIGDYG------- ------------------------VKQLR----PMFSKLT----------ILRLSVN--- NLYD-----GSVEVLAEEIC------------------------------KYKIIQTLG- ------------------------------LYSNHLTDVGAELVARVIEEC-PKLQVVK- --IGKN-NITHVG----------------------------------------------- ---------------------------GRRLAAAIQKSTS-IFDV--------------- ----------------------------------------------G--MWGNCIGDEGA EAFSEALKNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--SLSVNGITSRGGRCL---AEALQHN-SVLRIFWLVI--NEFTDEVAPHLA ELIRA-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TGLSHL--WLISNRLTVEGIGQLAEALG---------- ---------------------------------------------------HNTTLKEIC ------------------------------------------------------------ ---------------------------------------------VKGNQ-VSG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEEKLFATEKRLF--FH----------------------------- ---------------------------------------- >D_rerio_ENSDARP00000052748 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EKLRYELGRDTQFITSYSKSEE---- -TPLEDLYT---D------------TQM-------------ELLNDTG------ESLGYL QNLDQLLG-D--------HGV--FNPQAETIFITGDAGVGKSIMLQKLQNLWSRRELKTR -AKFFFKFRCRAFSAF-----KETDEISLKDLIFKHNCYPDGDPDNEVFAYIL-RFPETV VFTFDGYDELQMDF-DLDNV----PETVSPEEKTRPLLLLMNLLCGKLLKGSRKILSARS GT--EIQSRVIR-KKVFLKGFAPEHLKR-YLA---LHFPE-----------------Q-- -EHRMLVSDQLDANPHLCGLCSIPLFSWIILKSFKHLQS----VYD--DFELPG-SCITL TNVFLLLSEVFLGH-STAR-PGLLRRT---LRCPTETFKAGEQKLSGFARLALHGIETSK LVFTLDEAVCC--------------GLNDEDLQFGF--LRPASHYDS----S----SASS FEFLHETLQAFLAAFSLVLDAKLNPESILKFFSKC-KYKKSSR-LS-------------- -----C------IP---CL-K----NTKPRESDAFQT----------------------- -------N--FQFTNLFLCGLLSKSNAALLEHLVPP-S-AL-K-QKRKILKSYLSNSVKT HLKSLPRSPSTDIEGDKVHAMPNFLWMLRCIFETNSEDVAKMTANGISADYIKIAFCN-- ------------------------------------------------------------ -----IYSADCSA----L-------NFVLHHRR---KHLGVDMDNN-NINDYG------- ------------------------VKQLR----PSFSKMT----------VVRFCVN--- QLTD-----SGIEVLAEELI------------------------------RYKIVKVLG- ---------------------------IHSLYQNHITDVGAKQVAKIIEEC-PHLRTVK- --LGCN-NITSVG----------------------------------------------- ---------------------------GKYLASAIHKSKS-IFDI--------------- ----------------------------------------------G--MWGNCIGDEGA EAFAEALKNHP------------------------------------------------- ------------------------------------------------------------ -SL--TNL--R--------------------------------LIQ--NKISDDAASDLA EAFRS-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLTHL--MLIDNEFTIDGARQLSEGLK---------- ---------------------------------------------------DNTTLKEVN ------------------------------------------------------------ ---------------------------------------------IKGSR-ISE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AEEHLYQGDRRLR--F------------------------------ ---------------------------------------- >D_rerio_ENSDARP00000052379 ------------------------------------------------------RAELLA VLCGGGSDEPLESVLDLLLAQEVLVWEDYLRVRVAEKPLCANIRQLL-------DLVYDK GEDACSYFLAAIEQELAEEQKAGLCFGNGC--VMVGK--DRPATATSTLLADRPMLVRRL RDNIDGALNILLTTGCF------SIKDCDSVQLPVYTPSQ----------QV-------- ------------------------------------------------------------ ------------------RRLLDQVKFKGETAAKTLLEYLEQPEP-TSPISAE-KENTPS AD---------------------------CLVYQKKLRSSVASQSLFLSTYGGTGR---- -FSLDDIYT---D------------GHL-------------EVMNSSG------E-TTTL -GLEDVVG-P--------MGT--LNEDADTVLVSGEAGSGKSTLVQRLHLLWAREALLLN -TFLLFPFSCRKLNA-------EHRELSLKELLFLHCCWPDRNQD-EVFQFIL-DHPHLV LFTFDGLDEFK--L-GFTDE----ERHCCPTKQVPIPVLLFNLLQGTLMKGVMKVVTSRP HAVGPSLKRYLR-KEVLLKGFSPGGIDC-FVK---KHYSD-----------------P-- -AMATRVIESVQGNTALLGLCHIPVFCWIVIKCXQELLA----GQD-------G-IPQTI TDVYLLVLQHFFQR--KSSQPQS---G-----LGKAWLAEHLDTVLKLGELALEGLQTSC YVFSGYELQRN--------------RITEQDVGIGF--LIYCSDISV----ND----CKR YEFLHITLQCFFAALYVILNRNNDRSAISRLFQPR-NRQVSGL-SQ-------------- -----S------CLGQ-CMDHSV-------EESHEAE----------------------- -------TANLQITAQFVSGLLSQRHNNLLLECCPA-A-VR-E-RNVKQVVKSLSKRMQR HFKSIPRPVEG--EKKSMHAMPSFVWLIKCIYELQDNSIAQDAMAKLDVEHLKLTYCN-- ------------------------------------------------------------ -----IGPVECTA----L-------AYVLKNLR---KPVGLQLDNN-SVGDVG------- ------------------------VEQLL----PCLPMCH----------SLYLRNN--- NISD-----EGIRKLLEKGI------------------------------ECENFQKIA- ------------------------------LFNNKLTDTCTQYFSCLLKSK-QNFLALR- --LGNN-NITSVG----------------------------------------------- ---------------------------AEQLAEGLSYNQS-LQFL--------------- ----------------------------------------------G--LWGNKVGDRGA EVLADALTNSK------------------------------------------------- ------------------------------------------------------------ -TL--IWL--SLVDNGVGSAGACAL---AKFIRQN-KSLEELW----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LNKNSICKEGVDCLIEALK---------- ---------------------------------------------------MNTSVKKVW ------------------------------------------------------------ ---------------------------------------------LRGNN-LSP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QEEEQLSQQECRL--TF----------------------------- ---------------------------------------- >E_caballus_ENSECAP00000015042 -------------L------------------------SSPGCEMCTQEAFQAQRSQLVG LL-VSGSLEGFESVLDWLLSWDVLSWEDYESLSLVGQPLSHLARHLL-------DTVWKK GAWGCEQLVAAVREAQADSQSPEL--------PGHWD--PHSPQPAQDLQSHRPAIVRRL YSHVEGVLDLAHERGFI------SRYECDEIRLPIFTSSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQHVQELPV-LLALPFQ------- ------------------DAA--------CKKFMSKLRTTVSAQSRFLNTYDGAEN---- -LCLEEIYT---E------------NVL-------------EIRTELGMAGPPQQSPATL -GLEELFS-T--------RGH--LNKDADTVLVVGEAGSGKSTLLQQLHLLWAAGRDFQE -FLFVFPFSCRQLQC-------LAKPLSVRALLFEHCCWPDLGQQ-DVFQFLL-DHPDRV LLTFDGFDEFR--F-RFTDG----ERHCSPTDPTSVQNLLFNLLQGNLLKNARKVLTSRP DAVSALLRKYVH-TEFTLKGFSEEGIEL-YLR---KCHRE-----------------P-- -GLADRLISLLRATSALHGLCHLPVFSWMVSKCHQELLL----QGG-------G-SPKTT TDMYLLILQHFLLH--ASP-PDSAPGG-----LEPGLLRGRLPTLLHLGQLALWGLGTCC YVFSAKQLQAA--------------HVDSEDISLGF--LVRAKRAVP----GS----APP MEFLHITFQCFFAAFYLVLSADVPPSSLRYLFSCG-RPGSSLL-AR-------------- -----L------LPAM-CVQGSRCKEDS-KALLQEAE----------------------- -------PHNLQITAAFLAGLLSREHRGLLAKCQGS-ETAL-R-QRQACARWCLARSLHK HFHSIPPAVAG--EAKSMHAMPGFIWLIRSLYEMQEERLAQEAVRGLDVGHLKLTFCS-- ------------------------------------------------------------ -----VGPAECAA----M-------AFVLRHLR---RPVALQLDHN-SVGDVG------- ------------------------VEQLL----PCLSVCT----------ALYLRDN--- NISD-----RGICQLIERAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMARLLMCK-QNFLALR- --LGNN-HITAAG----------------------------------------------- ---------------------------AVVLAQGLRANTS-LQFL--------------- ----------------------------------------------G--FWGNKVGDKGA QALAEALGNHP------------------------------------------------- ------------------------------------------------------------ -SL--KWL--SLVGNSIGSAGAQAL---AVMLEKN-VALEELCLEE--NHLQDEGVCSLA EGLQR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKVL--KLSNNCITYRGAEALLQTLE---------- ---------------------------------------------------RNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEIEKLSHRDARL--LL----------------------------- ---------------------------------------- >T_rubripes_ENSTRUP00000021180 --------------------------MCVAGVQVKPSLYGNGKSMRVQDLVLNQRTEILR VLCSSGSAEPVEHVTDILLSQGELTWEDYQSIHVSGRPLYTNARQLL-------DVVYLK GESSCGLFLEALKQVLPEEQPAGFSFPDHWWDPEVRE--ECQNTFCQTLLTQRPSLVSTL QHCVDGALEALLTSAHF------TSADCEGIRLPLRTPSQ----------QA-------- ------------------------------------------------------------ ------------------RCLLDHVRAKGEAAAKFLLEYIQQGEE-SGSILNK-KTQTVS RALPETHIR---EKQLVYSDQ--------IFYFQKKLRSSLSAQSCFLSTYGGTSH---- -MSLDDIYT---D------------GQL-------------ELAEACP------DVHGPI -GLKDITG-E--------VGT--INEEADTVLVSGEAGSGKSTLLQRLHLLWAREAALLE -YLLLFPFSCRRLNT-------ELSELSFKELLFQHCCWPDRDQD-EIFDFIQ-DHPHLI LFTFDGLDELK--Q-SFSDE----HRLCCPTQRAPVHVLLFNLIQGSLLKGVRKVVTSRP SAVTPVLKKNLC-KEVLLKGFSPSGIDC-FVR---KHHSD-----------------P-- -TVAAKVLQSLHTNTTLLGLCHSPVLCWIVSCCHKELLG----CGE-------G-SPQTI TDVYLTIVEHFFQH--HSP-LRS---T-----GKISWHREYLDPVLRLGQLAFKGIVSTC YIFSDKDLDPC--------------AITKEDLSLGF--LIQSKDLSV----FR----SKC YEFLHVTMQCFFAAVYVVVSKDLDRSTIPKLFELK-NLKETSL-RT-------------- -----A------CFSA-CLLYQQVDECSLDKDATAVE----------------------- -------TPNLQMTATFASGLLSQRHRSLWLHCCPA-T-AI-D-RKTRQVSKCLSKGMQK HFKSIPQPVAG--EKKSMHAMPGFVWLIKCIYEMQECSIAKDAMSKLEVDHLKLTYCN-- ------------------------------------------------------------ -----IGPVECTA----L-------AFVLQHLN---NPVGLQLDNN-TVGDVG------- ------------------------VEQLL----PCMHICH----------SLYLRNN--- NITD-----EGIHKLIAKSL------------------------------NISIVFLCS- ------------------------------LFNNRLTDACTQDFSLLLKTK-QDFISLR- --LGNN-NITAEG----------------------------------------------- ---------------------------AKQLAEGLRVNKS-LKFL--------------- ----------------------------------------------G--LWGNSIGDAGA EALASALEGNT------------------------------------------------- ------------------------------------------------------------ -TL--VWLSHSLVGNGIGSAGACAL---SKVVKNN-VSLEELW----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LTENCITRMGVECLIEALQ---------- ---------------------------------------------------HNANVKSIW ------------------------------------------------------------ ---------------------------------------------LRNND-LCL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVEEMAQRESRL--LF----------------------------- ---------------------------------------- >O_latipes_ENSORLP00000017416 --------------------------------------------PSAMERLLKQRTEILR ALCSGGSAEHLESILDILLAQEEITWEDYQNVQVTGRPLNSNARNLL-------DLVYTK GADTCELFLAALKQILPKEQGAGLCFLEHSSTLDELE--VTQRTWTETVLKRRPSLVWKL QGSVHDAVEALVESGHF------SSADANEVLLPVYTPSQ----------QA-------- ------------------------------------------------------------ ------------------RRLLDHVGSKGESASKMLLQFILRNPVI-------------- ------------LFLPFVAKV--------LKRFKEKLSSSVSAESCFLSTYGRTNH---- -MPLEVIFT---E------------VQL-------------ALPD-----------NKPV -SLEEIVS-P--------KDA--VNGEADTVLVSGVAGSGKSTLLQRLHLLWSQGSALRD -FLLVFPFSCRRLNS-------ELRELSLQELLFQHCCWPDRGQE-EIFQFIL-DHPQLI LFTFDGLDELK--Q-SFSDD----QRLCCPTQRAPVHVLLFNLIQGSLMKGVWKVVTSRP DAVGPGLKQHLR-REVLLKGFSPAGIES-FVR---QHHRD-----------------P-- -TVAAKVLESLQANTALLGLCHSPVLCWIVSQCHKELLG----CGE-------G-RPQTL TDVYLMILQHFFQH--KHL-LKN---P-----IGAGWLQEHKETVLHLGKLAFDGISTSC YVFSSTDLELC--------------NVGEGELLTGF--LTQSRNVSQ----ID----RKC YEFLHLTIQCFFAALHIVLSPNVERSAVTKLFDLW-NMTEKSS----------------- -----T------CFGL-CLPD--KQSWATKNDRNAVE----------------------- -------TPNLQIIATFVSGLLSQRHKHLWLHCCPG-A-AL-E-QKGRQVVKSLSKGMQR HFRSIPKPVPG--EKKSMHALPHFVWLIKCIYEMQDSQIAKDAMSKLEVDHLKLTYCN-- ------------------------------------------------------------ -----IGPVECTA----L-------AFVLQHLK---NPVGLNLDNN-SVGDVG------- ------------------------VEQLL----PCLHICS----------SLYLRNN--- NITD-----EGIRKLTDKGV------------------------------QCDSFQKIA- ------------------------------LFNNRLTDACTQHFSHLLKTK-QNFLALR- --LGNN-NITADG----------------------------------------------- ---------------------------AKLLAEGLKQNGS-LMYL--------------- ----------------------------------------------GKRLWGNRIGDEGA EVIANALESST------------------------------------------------- ------------------------------------------------------------ -SL--VWL--SLVGNGVGSTGACAL---SKVIRNS-PSLEELWLTD--NCITRTGVESLI EALES-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PRVKSVWKRLTDNCITRTGVESLIEALE---------- ---------------------------------------------------NNPRVKSVW ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000013836 -------------M----GEEGGSVSHDEEERASVLLGHSLGCEMCSQEAFQAQRSQLVE LL-VSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLL-------DTVWNK GTWACQKLIAAAQEAQADSQSPKL--------HGCWD--PHSLHPARDLQSHRPAIVRRL HNHVENMLDLAWERGFV------SQYECDEIRLPIFTPSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQHVQELPV-PLALPLE------- ------------------AAT--------CKKYMAKLRTTVSAQSRFLSTYDGAET---- -LCLEDIYT---E------------NVL-------------EVWADVGMAGPPQKSPATL -GLEELFS-T--------PGH--LNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGRDFQE -FLFVFPFSCRQLQC-------MAKPLSVRTLLFEHCCWPDVGQE-DIFQLLL-DHPDRV LLTFDGFDEFK--F-RFTDR----ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRP AAVSAFLRKYIR-TEFNLKGFSEQGIEL-YLR---KRHRE-----------------P-- -GVADRLIRLLQATSALHGLCHLPVFSWMVSKCHQELLL----QEG-------G-SPKTT TDMYLLILQHFLLH--ATP-PDSASQG-----LGPSLLRGRLPTLLHLGRLALWGLGMCC YVFSAQQLQAA--------------QVSPDDISLGF--LVRAKGVVP----GS----TAP LEFLHITFQCFFAAFYLALSADVPPALLRHLFNCG-RPGNSPM-AR-------------- -----L------LPTM-CIQGSEGKDSSVAALLQKAE----------------------- -------PHNLQITAAFLAGLLSREHWGLLAECQTS-EKAL-L-RRQACAHWCLARSLRK HFHSIPPAAPG--EAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLQHLR---RPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALYLRDN--- NISD-----RGICKLIECAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMAKLLACR-QNFLALR- --LGNN-HITAAG----------------------------------------------- ---------------------------AQVLAQGLRGNTS-LQFL--------------- ----------------------------------------------G--FWGNRVGDEGA QALAEALGDHQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLAKN-VMLEELCLEE--NHLQDEGVCSLA EGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKIL--KLSNNCITYLGAEALLQALE---------- ---------------------------------------------------RNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVDKLGCRDTRL--LL----------------------------- ---------------------------------------- >R_norvegicus_ENSRNOP00000018996 MLEVSDSLFLTELLRTVAAGQCAVFVAEFIGRSQGLWSGIWGCDMCSQEDFQAQRSQLVA LL-VSGSLEGFESILDWLLSWDVLSREDYEGLSLPGQPLSHSARRLL-------DTVCNK GVWGCQKLFEAVQEAQANSHTFEL--------QGCWD--VHSLHPTRDLQSHRPAIVRRL CSHVEAILELARDEGFL------SQYECEEIRLPIFTSSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLAAVKANGLAAFLLQHVRKLPA-SLSLPYE------- ------------------AAE--------CQKFTAKLRTMVSAQSRFLSTYDGSEN---- -LCLEDIYT---E------------NTL-------------ELRTEVGTAGALQKSPATL -GLEELFG-T--------HGH--LNKDADTILVVGEAGSGKSTLLQRLHLLWASGQNFRE -FLFIFPFSCRQLQC-------MTKPLSLRTLLFEHCCWPDVGQD-DVFQFLL-DHPDRV LLTFDGLDEFK--F-RFTDR----ERHCSPLDPTSVQTLLFNLLQGNLLKNACKVLTSRP DAVSALLRKFVR-TECHLKGFSEEGIKL-YLR---KHHRE-----------------P-- -GVADRLIHLIQATSALHGLCHLPVFSWMVSRCHRELLL----QNR-------G-FPTTS TDMYLLILQHFLLH--ASP-PDSFPLG-----LGPGLLQSRLSTLLHLGHLALQGLAMSC YVFSAQQLQAA--------------QVDSEDISLGF--LVRAQSVVP----GS----KAP LEFLHITFQCFFAAFYLAVSADTSAASLKHLFSCG-RPGNSLL-LR-------------- -----L------LPNL-CIQGSRVK-GGQAALLQKAE----------------------- -------PHNLQITAAFLAGLLSQQHRDLLAACQVP-ERVL-L-QRQARARSCLAHSLRE HFHSIPPAVPG--ETKSMHAMPGFIWLIRSLYEMQEVQLAREAVRRLDIGHLKLTFCR-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLQHLQ---RPVALQLDHN-SVGDVG------- ------------------------VEQLL----PCLGVCT----------ALYLRDN--- NISD-----RGARTLVECAL------------------------------RCEQLQKLA- ------------------------------LFNNKLTDGCASSVAKLLAHK-QNFLSLR- --VGNN-HITAAG----------------------------------------------- ---------------------------AEVLAQGLKSNTS-LQFL--------------- ----------------------------------------------G--FWGNSVGDKGS QALAEVVADHQ------------------------------------------------- ------------------------------------------------------------ -RL--KWL--SLVGNNIGSVGAHAL---ALMLEKN-KSLEELCLEE--NHICDEGVYSLA EGLKR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------STLKFL--KLSNNGITYRGAEALLQALN---------- ---------------------------------------------------RNSTVLEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEAQTLSSSDARL--LL----------------------------- ---------------------------------------- >P_pygmaeus_ENSPPYP00000008293 -------------M----GEKGGSVSHDEEERASVLLGHSLGYEMCSQEAFQAQRSQLVE LL-VSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSQLARRLL-------DTVWNK GTWACQKLIAAAQEAQADSQSPKL--------HGCWD--PHSLHPARDLQSHRPAIVRRL HSHVEDMLDLAWERGFV------SQYECDEIRLPIFTPSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQHVQELPV-PLALPLE------- ------------------AAT--------CKKYMAKLRTTVSAQSRFLSTYDGAET---- -LCLEDIYT---E------------NVL-------------EVWADVGMAGPPQKSPATL -GLEELFS-T--------PGH--LNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGRDFQE -FLFVFPFSCRQLQC-------MTKPLSVRTLLFEHCCWPDVGQE-DIFQLLL-DHPDRV LLTFDGFDEFK--F-RFTDR----ERHCSPTDPTSVQTLLFNLLQGNLLKNACKVVTSRP AAVSAFLRKYIR-TEFNLKGFSEQGIEL-YLR---KRHRE-----------------P-- -GVADRLIRLLQATSALHGLCHLPVFSWMVSKCHQELLL----QEG-------G-SPKTT TDMYLLILQHFLLH--ATL-PDSASQG-----LGPSLLRGRLPTLLHLGRLALWGLGMCC YVFSAQQLQAA--------------QVSPDDISLGF--LVRAKGVMP----GS----IAP LEFLHITFQCFFAAFYLALSADVPPALLRHLFNCG-RPGNSPM-AR-------------- -----L------LPTM-CIQGSEGKDSSVAALLQKAE----------------------- -------PHNLQITAAFLAGLLSREHWGLLAECQTS-EKAL-L-RRQACARWCLARSLRK HFHSIPPAAPG--EAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLQHLR---RPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALYLRDN--- NISD-----RGICKLIECAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMAKLLASR-QNFLALR- --LGNN-HITAVG----------------------------------------------- ---------------------------AQVLAEGLRGNTS-LQFL--------------- ----------------------------------------------G--FWGNRVGDEGA QALAEALGDHQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLAKN-VMLEELCLEE--NHLQDEGVCSLA EGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKIL--KLSNNCITYLGAEALLQALE---------- ---------------------------------------------------RNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVDKLGCRDTRL--LL----------------------------- ---------------------------------------- >M_musculus_ENSMUSP00000050538 --------------------------------------------MCSQEEFQAQRSQLVA LL-ISGSLEGFESILDWLLSWDVLSREDYEGLSLPGQPLSHSARRLL-------DTVWNK GVWGCQKLLEAVQEAQANSHTFEL--------YGSWD--THSLHPTRDLQSHRPAIVRRL YNHVEAMLELAREGGFL------SQYECEEIRLPIFTSSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLAAVKANGLAAFLLQHVRELPA-PLPLPYEGYSLCRS RCDRGFTLI---CLFCILAAE--------CQKFISKLRTMVLTQSRFLSTYDGSEN---- -LCLEDIYT---E------------NIL-------------ELQTEVGTAGALQKSPAIL -GLEDLFD-T--------HGH--LNRDADTILVVGEAGSGKSTLLQRLHLLWATGRSFQE -FLFIFPFSCRQLQC-------VAKPLSLRTLLFEHCCWPDVAQD-DVFQFLL-DHPDRV LLTFDGLDEFK--F-RFTDR----ERHCSPIDPTSVQTLLFNLLQGNLLKNACKVLTSRP DAVSALLRKFVR-TELQLKGFSEEGIQL-YLR---KHHRE-----------------P-- -GVADRLIQLIQATSALHGLCHLPVFSWMVSRCHRELLL----QNR-------G-FPTTS TDMYLLILQHFLLH--ASP-PDSSPLG-----LGPGLLQSRLSTLLHLGHLALRGLAMSC YVFSAQQLQAA--------------QVDSDDISLGF--LVRAQSSVP----GS----KAP LEFLHITFQCFFAAFYLAVSADTSVASLKHLFSCG-RLGSSLL-GR-------------- -----L------LPNL-CIQGSRVKKGSEAALLQKAE----------------------- -------PHNLQITAAFLAGLLSQQHRDLLAACQVS-ERVL-L-QRQARARSCLAHSLRE HFHSIPPAVPG--ETKSMHAMPGFIWLIRSLYEMQEEQLAQEAVRRLDIGHLKLTFCR-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLQHLQ---RPVALQLDYN-SVGDVG------- ------------------------VEQLR----PCLGVCT----------ALYLRDN--- NISD-----RGARTLVECAL------------------------------RCEQLQKLA- ------------------------------LFNNKLTDACACSMAKLLAHK-QNFLSLR- --VGNN-HITAAG----------------------------------------------- ---------------------------AEVLAQGLKSNTS-LKFL--------------- ----------------------------------------------G--FWGNSVGDKGT QALAEVVADHQ------------------------------------------------- ------------------------------------------------------------ -NL--KWL--SLVGNNIGSMGAEAL---ALMLEKN-KSLEELCLEE--NHICDEGVYSLA EGLKR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------STLKFL--KLSNNGITYRGAEALLQALS---------- ---------------------------------------------------RNSAILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEIQTLSSRDARL--LL----------------------------- ---------------------------------------- >M_mulatta_ENSMMUP00000016010 -------------MGFDGGRGGGPVSPDEEERASVLLGHFLGCEMCSQEAFQAQRSQLVE LL-VSGSLEGFESVLDWLLSWEVLSWEDYEGIHLLGQPLSHLARRLL-------DTVWNK GTWACQKLVAAAQEAQADSQSPKL--------HGCWD--PHSLHPAQDLQSHRPAIVRRL HSHVEGVLDLARERGFV------SQYECDEIRLPIFTPSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQHVQELPV-PLALPLE------- ------------------AAT--------CRKYMAKLRTTVSAQARFLSTYDGAET---- -LCLEDIYT---E------------NGL-------------EVWADVGMAGPPQKSPATL -GLEELFS-T--------RSH--LNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGRDFQE -FLFVFPFSCRQLQC-------VAKPLSVRTLLFEHCCWPDVDQE-DIFQFLL-DHPDRV LLTFDGFDEFK--F-RFTDH----ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVMTSRP AAVSAFLRKYIR-TEFNLKGFSEQGIEL-YLR---KRHRE-----------------P-- -GVADRLIRLLQGTSALHGLCHLPVFSWMVSKCHQELLL----QEG-------V-SPKTT TDMYLLILQHFLLH--ATS-PDSASQG-----LGPSLLRGRLPTLLHLGRLALWGLGMCC YVFSAQQLQAA--------------QVSPDDISLGF--LVRAKGVMP----GS----TAP LEFLHITFQCFFAAFYLAFSADVSPALLRHLFNCG-RPGNSPM-AR-------------- -----L------LPTL-CIQGSEGKDGSVAALLQKAE----------------------- -------PHNLQITAAFLAGLLSREHWDLLAECQAS-EKAL-L-RRQACARWCLARSLRK HFHSIPPAAPG--EAKSMHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLRHLR---QPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALYLRDN--- NISD-----RGICKLIECAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMAKLLACR-QNFLALR- --LGNN-HITAAG----------------------------------------------- ---------------------------ARVLAEGLRGNAS-LQFL--------------- ----------------------------------------------G--FWGNRVGDEGA QALAEALGDHQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLAKN-VMLEELCLEE--NHLQDEGVCCLA EGLKR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKIL--KLSNNCITYLGAEALLQALE---------- ---------------------------------------------------RNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEADKLGCRDTRL--LL----------------------------- ---------------------------------------- >M_domestica_ENSMODP00000016381 -------------------------------------------EMYTQEFFQAQRSQLVG RL-ALRSLENFESVLDYLLSWEVLTWEDYESVSLPGQPLSTLARRLL-------DIVWNK GGQSCELLFAAVQKAEGADEQTEP--------LRKWS--QNESCSVQDLQKHRPTIVRKI YGHVESILNLLLERGFL------TKYECDEIRLPIFTSSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDFAKVKDNGVAQFLLQHILQLPVLPVPLP-D------- ------------------VTA--------CKKYTAKLKATVSAQSRFLSTYDGTEN---- -LCLENIYT---E------------NIL-------------EIRKNLSLGVPSQKGHDTL -ELAEIFN-H--------KGC--INEDADTVLLVGEAGSGKSTLLQQLHRLWATGQQFQD -FLFVFPFSCRQLQS-------MDKPVSVQSLLFEQCCWPNEGQQ-EVFRYLL-DHPDRV LLTFDGFDEFK--F-RFTER----ETHCSPTDPTSAQNLLFNLLRGNLMKNTKKVLTSRP HAICPSLRKYVR-KELSLMGFSQDGIEL-FMR---KHHSD-----------------A-- -GVADRLVQLVKATSALHGLCHVPVFSWIVSRCHKELLL----HGS-------G-FLKTT TDMYLLVLRHFISH--ASP-ED-VAWG-----LGASTLRPRLPTILRLGRLALWGLGTCS YVFSAEQLRAS--------------GVDEEDLSLGF--LVPSKSFPP----ES----SAP VEFLHITLQCFFAAFYLLLGADVNPSAIRCVFGGH-KKPHQPL-PR-------------- -----L------FPMA-CFQSPEPEEESVLTLLQRAE----------------------- -------THNVRITAVFLAGLLSQEHWRLVTECRGT-STPL-L-QKKSRVRRCLARGLRR HFRSIPRAVPG--EVKSMHAMPEFVWLIRSLYEMQDEHLARKAVSKLEVGHLKVTYCN-- ------------------------------------------------------------ -----IGPAECAA----L-------AFVLKNLQ---QPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLSVCR----------ALYLRDN--- NISD-----QGICRLVDQAL------------------------------QCDQFQKLA- ------------------------------LFNNKLTDDCAHSLASLLKYK-QNFLALR- --LGNN-HITAVG----------------------------------------------- ---------------------------AKVLAEGLKDNDS-LQFL--------------- ----------------------------------------------G--LWGNTVGDEGA QALACALHDHH------------------------------------------------- ------------------------------------------------------------ -SL--KWL--SLVGNNIGSVGTQAL---ALMLEKN-VSLEELCLEE--NHLQDEDMCTLV DGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLEVL--KLSNNRITHRGVSALLQVLE---------- ---------------------------------------------------SNATIRSIW ------------------------------------------------------------ ---------------------------------------------LRGNT-FTP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEIEQLSLMDSRL--LF----------------------------- ---------------------------------------- >G_aculeatus_ENSGACP00000022068 --------------------------------------------MSAQELVLRQRTEILH ALCSSGSAEHLDQVLDILLSQGELVPEDYQNIQVPGRSLYTKTRQLL-------DLVHAK GVDTCVLFYAALKQVLPEGQGAGFSFPGIGSNGEEKE--DHPSTSTRTLLAQRPSLVSEL QGCVEDALHALVITGHF------TSADCNDVRLPVYTPSQ----------QA-------- ------------------------------------------------------------ ------------------RRLLDHVRAKGESAAKVVLRYVQQKQG-SGSSLNQ-ENWTPP KV---------------------------VLKYQKKLSSSVSAQSCFLSTYGGTSH---- -MALDDIYT---E------------GQL-------------ELAHYCG------DVHGPL -GLEDVVG-A--------VGT--VNKEADTVLVSGDAGGGKSTLLQRLHLLWARGTLLRE -FLLLFPFSCRRLNS-------ERQDLSVKELLFDHCCWPDREQE-EIFQFIL-DHPHLI LFTFDGLDELK--H-GFSDE----HRLCCPTQRAPVQILLFNLIQGSLMKGVRKVVTSRP EAVGPVLKKHLR-KEVLLQGFTPSGIEC-FVR---KHHSD-----------------P-- -AVASKVLASLRTKNALLGLCHSPVLCWIVSHCHKELLG----CGE-------G-SPRTI TDVYLMILQHFFQH--RSS-PKS---T-----TGTSWLQEHLDTVLHLGQLAFEGIGTSC FIFSPADLETC--------------GVTEKDICMGF--LVQSKDMSP----TR----SKC FEFLHLMMQCFFAALYIVSSNNADRSIISNLFEPQ-NMRATGLGSS-------------- -----S------CFGA-CSSSAGKQGQALNGEAASEE----------------------- -------RPNLKITATFVSGLLSQRHRSLWLHCCPS-A-VT-E-KRVRQVVRCLSKGMHK HFKSIPPPVDG--EKKSMHAMPGFVWLIKCIYEMQDSRVAKDAVSKLEVDHLKLTYCN-- ------------------------------------------------------------ -----IGPVECTA----L-------AYVLQHLR---NPVGLQLDNN-SVGDVG------- ------------------------VEQLL----PCMHNCH----------SLYLRNN--- SITD-----EGIRKLLATGI------------------------------HCDSFRKIA- ------------------------------LFNNKLTDACTQHFSHLLKSR-QDFLSIR- --LGNN-NITEEG----------------------------------------------- ---------------------------AKQLAEGLKSNRS-LKYL--------------- ----------------------------------------------G--LWGNKIGDAGA VALASALQSST------------------------------------------------- ------------------------------------------------------------ -SL--VWL--SLVGNGVGNAGAGAL---ANVIRNS-TSLEELWLTF--GNSQDDSAS--L APLSP-H----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PLVFCK--RLTENCITRSGVECLVQALK---------- ---------------------------------------------------ENTRMKSVW ------------------------------------------------------------ ---------------------------------------------VINND-LTL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVEDLRQRESRL--TF----------------------------- ---------------------------------------- >H_sapiens_ENSP00000300589 -------------M----GEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVE LL-VSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLL-------DTVWNK GTWACQKLIAAAQEAQADSQSPKL--------HGCWD--PHSLHPARDLQSHRPAIVRRL HSHVENMLDLAWERGFV------SQYECDEIRLPIFTPSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQHVQELPV-PLALPLE------- ------------------AAT--------CKKYMAKLRTTVSAQSRFLSTYDGAET---- -LCLEDIYT---E------------NVL-------------EVWADVGMAGPPQKSPATL -GLEELFS-T--------PGH--LNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQE -FLFVFPFSCRQLQC-------MAKPLSVRTLLFEHCCWPDVGQE-DIFQLLL-DHPDRV LLTFDGFDEFK--F-RFTDR----ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRP AAVSAFLRKYIR-TEFNLKGFSEQGIEL-YLR---KRHHE-----------------P-- -GVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLL----QEG-------G-SPKTT TDMYLLILQHFLLH--ATP-PDSASQG-----LGPSLLRGRLPTLLHLGRLALWGLGMCC YVFSAQQLQAA--------------QVSPDDISLGF--LVRAKGVVP----GS----TAP LEFLHITFQCFFAAFYLALSADVPPALLRHLFNCG-RPGNSPM-AR-------------- -----L------LPTM-CIQASEGKDSSVAALLQKAE----------------------- -------PHNLQITAAFLAGLLSREHWGLLAECQTS-EKAL-L-RRQACARWCLARSLRK HFHSIPPAAPG--EAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS-- ------------------------------------------------------------ -----VGPTECAA----L-------AFVLQHLR---RPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALYLRDN--- NISD-----RGICKLIECAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMAKLLACR-QNFLALR- --LGNN-YITAAG----------------------------------------------- ---------------------------AQVLAEGLRGNTS-LQFL--------------- ----------------------------------------------G--FWGNRVGDEGA QALAEALGDHQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLAKN-VMLEELCLEE--NHLQDEGVCSLA EGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKIL--KLSNNCITYLGAEALLQALE---------- ---------------------------------------------------RNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVDKLGCRDTRL--LL----------------------------- ---------------------------------------- >B_taurus_ENSBTAP00000027887 --------------------------------------------MCAQDAFQTQRSQLVE LL-VSGSLEGFESILDRLLSREVLSWEDYEGLSLVGQPISHLARRLL-------DTIWNK GTWGCEQLTAAVREAQADSQPPEL--------PSSWD--PHSPHPARDLQSHRPAIVRRL YGHVEGVLDLTQQRGFI------SQYETDEIRRPIFTSSQ----------RA-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLQCIQELPV-PLALPFE------- ------------------DAA--------CKKYVSKLRTVISAQSRFLSTYDGAEN---- -LCLEEVYT---E------------NVL-------------EIQMEVGMAGPSQQSPTTL -GLEELFS-T--------RDH--FNKEADTVLVVGEAGSGKSTLLQQLHLLWASGRAFQE -FLFVFPFSCRQLQC-------LVKPLSMRTLLFEHCCWPDLGPQ-DVFQVLL-DHPERI LLTFDGFDEFR--F-RFTDQ----ERHCCPTAPTSVQSLLFNLLQGNLLKNARKVLTSRP SAVSASLRKHVR-TELSLKGFSEEGIEL-YLR---KRHRE-----------------P-- -GVADRLLCLLRATSALHGLCHLPVFSWMVSKCHEELLL----QGR-------G-SPKTT TDMYLLILRHFLLH--ASP-LPLATHG-----LGPSLIQGRLPTLLHLGRLALWGLGTCC YVFSAKQLQAA--------------HVDSEDLSLGF--LVLAKRVVP----GS----TAP LEFLHITFQCFFAAFYLALSADTPPSSLRHLFQDH-RPESSPL-AR-------------- -----V------LPKL-FLRGSRCREGSVAALLQGAE----------------------- -------PHNLQITGAFLAGLLSQEHRSLLAECQAS-ETAL-L-RRWDCVRRCLTRSLRE HFRSIPPALPG--EAKSMHALPGFLWLIRSLYEMQEERLAREAVCRLNVGHLKLTFCG-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLRHLR---RPVALQLDHN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALYLRDN--- NISD-----RGICKLVEHAL------------------------------RCEQLQKLA- ------------------------------LFNNKLTDGCAHSMARLLACK-QNFLALR- --LGNN-HITAAG----------------------------------------------- ---------------------------AEVLAQGLRTNNS-LQFL--------------- ----------------------------------------------G--FWGNQVGDEGA QALAAALGDHQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLEKN-MALEELCLEE--NHVQDEGVCFLA KGLAR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKVL--KLSNNHISSLGAEALLRALE---------- ---------------------------------------------------KNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEIEKLSHQDTRL--LL----------------------------- ---------------------------------------- >O_anatinus_ENSOANP00000021142 -----------------VSGDGFGLDRWSPHRFISFLSLLSGRTMLPPETFRAQRSQLVA QL-GRGSTETFESVLDFLLSWDVLTWEDYESVSVRGHPPSQLARRLL-------DIVGNK GGRSGELLVAAVREAEREVRRAG----------GSWERLPEASGPIWDLQRQRPAVVRKI YGHLDDLLRLLLDRGFV------SKYECDEIRLPIFTTSQ----------QA-------- ------------------------------------------------------------ ------------------RRLLDLAKAKENGMVEFLLHRVQQLPDLPAPLP-D------- ------------------DGV--------FEKYQSKLRATLSAQSRFLSTYDGMEN---- -LCLEDVYT---E------------NAL-------------EIRKIDGASEPWRKGPAPL -GLPDLFD-P--------GGS--LNEDADTVLLVGGAGSGKTTLLQRLVWLWATGRAFQD -CLLVFPFSCRQLQR-------LGKPVSVRTLFFEHCCWPDGRQR-DLFRFIL-DRPQRV LLTFDGLDEFR--F-RFAEG----VRHCSPTEPTSVQNLLVNLIQGNLMKGSRKVLSSRP EAVTACLRKYVR-KEVGLRGFSQEAVER-FMR---KHHGD-----------------P-- -RVADRIVRLVGATPALRGLCHVPVFSWIVSRCHVELLRLRQGGGG-------G-APKTM TDMYFLIVRHLVLR--S---PLEGDRG-----PAGGVWRGRLPALLRLGELALGGLGAGC YVFSAGQLQAA--------------GVSAEDLSLGF--LVPSKGSAG----GAGGSPEAR FEFLHVTFQCFLAALYLLLHGDVAPAAVGHLFHRP-RKSRV-L-EL-------------- -----L------YPRL-CIPAARREEGRPGSLPWGAE----------------------- -------TVDVQLTASFLAGLLSGTNFAPLAESHGS-E-AL-L-RKRASARKCLARGIER HFRSIPPAVPG--ELKSLHALPAFLWLIKSLYEMQDEGLARRAVRGFEVEHVKLTYCG-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLRFLR---RPVSLQLDYN-SVGDVG------- ------------------------LEQLL----PCLKVCR----------ALYLRDN--- NISD-----HGISKLVDQAL------------------------------LCDSLQKLA- ------------------------------LFNNKLTDDSAHSLAKLLKYK-ENFLALR- --LGNN-HITAVG----------------------------------------------- ---------------------------AKVLAEGLEGNHS-LQFL--------------- ----------------------------------------------G--LWGNTVGEEGA QALADALHGHR------------------------------------------------- ------------------------------------------------------------ -SL--KWL--SLVGNNVGSVGARAL---ALMLGKN-VVLEELCLEE--NRLNDQDVCSLA EGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKVL--KLSNNNITYQGVVSLLQTLK---------- ---------------------------------------------------KNDTLKSIW ------------------------------------------------------------ ---------------------------------------------LRGNT-FTP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEIESLSFMDPRL--LL----------------------------- ---------------------------------------- >C_familiaris_ENSCAFP00000030474 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------A-------- ------------------------------------------------------------ ------------------RRLLDLATVKANGLAAFLLRHVQELPV-PLAMPSE------- ------------------DAA--------CKKYMSKLRTTISSQSRFLSTYDGAEN---- -LCLEEIYT---E------------NVL-------------EIRTEMGLARSPQKSPATL -SLEELFS-T--------CGH--LNEDADTVLVVGEAGSGKSTLLQRMHLLWASGRDFQE -FLFVFPFSCRQLQC-------VAKPLSVQMLLFEHCCWPDFGQQ-EVFQFLL-DHPNRV LLTFDGFDEFR--F-RFSDH----ERHCSPTDPTSVQNLLFNLLQGNLLKNARKVLTSRP DAVSALLRKYLR-LEINLKGFSEEGIEL-YLR---KCHRE-----------------P-- -GVADRLIRLLKTTSALHGLCHLPVVSWMVSKCHQELLL----HGG-------G-SPKTS TDMYLLILQHFLLH--ASP-PDSVPHS-----LGSHLLRGRLPTLLHLGWLALWGLGMCC YVFSAKQLQAA--------------HIDDEDISLGF--LVHAKTVGP----GS----TTP LEFLHITFQCFFAALYLVLSTDVSPSLLRQLFICH-GPRSSLL-AR-------------- -----L------LPTT-CVPRSERKEGSLAALLQEAE----------------------- -------PHNLQITAAFLAGLLSREHRGLLAECQAN-EEAL-L-RLQGRAQGCLSRSLHQ HFRSIPPAVPG--EAKSMHAMPGFLWLIRSLYEMQEERLAREAVRGLTVGHLKLTFCG-- ------------------------------------------------------------ -----VGPPECAA----L-------AFVLRHLR---RPVALQLDHN-SVGDIG------- ------------------------VEQLL----PCLSVCK----------ALYLRDN--- NISD-----RGICKLIEHAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSMARLLACK-QNFLALR- --LGNN-RITAAG----------------------------------------------- ---------------------------AQALAEGLRANTS-LQFL--------------- ----------------------------------------------G--WKFPRVRGREW VALGCFVIAFH------------------------------------------------- ------------------------------------------------------------ -SINRKFR--ILVGNDIGSVGARAL---ALMLEKN-VALEELCLEE--NHLQDEGVCSLA KGLER-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKVL--KLSNNCITYLGAEGLLQALE---------- ---------------------------------------------------KNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEMERLSQKDTRL--LL----------------------------- ---------------------------------------- >O_cuniculus_ENSOCUP00000011052 -------------L----GE-CALVSLREQERAGV-PPELPXXXXXXXXXXXXXXXXXXX XX-XXXXXXGFESILDLLLSWEVLSWEDYEGLRLVGQPLSHLARRLL-------DTVWNK GTWGCQKLIAAVQEAQDSSQCPEL--------HGCWD--PHSLHPAQDLQSHRPAIVRRL YSHVEGVLDLALEQGFI------SQYECDEIRLPIFTSSQ----------RX-------- ------------------------------------------------------------ ------------------XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX------- ------------------XAA--------CKKYMSKLRTIVAAQSRFLSTYDGAEN---- -LCLEDIYT---E------------NTL-------------EVRTEVGMAGPLHKSPAAL -GLEELFS-P--------NGH--LNEDADTVLVVGEAGSGKSTLLQQVHLLWATGQDFQE -FLFVFPFSCRQLQC-------VARPLSVMTLLFEHCCWPDVGQQ-DVFQFLL-DHPDRI LLTFDGFDEFK--F-KFTDH----ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVLTSRP DAVSAFLRKYVR-TEFNLKGFSEEGIEL-YLR---KCHRE-----------------P-- -GVADRLIHLLQTTSALHGLCHLPVFSWMVSKCHQELLL----QDG-------G-SPKTT TDMYLLILQHFLRH--ASL-PDSASQG-----LGPSLLQGRLPTLLRLGQLALWGLGMCC YVFSAQQLQAA--------------QVDPDDISLGF--LVQA-GVVP----GS----TAL LEFLHITFQCFLAAFYLVLSTDVPTAPLRYLFNCC-RPGXXXX-XX-------------- -----X------XXXX-XXXXXXXXXXXVAALLQKTE----------------------- -------PHNLQITAAFLAGLLSREHRDLLAACQAS-ERSL-L-RRRACARWCLARSLHK HFRSIPPAVPG--EAKSMHAMPGFLWLIRSLYEMQEERLAQEAVRGLNVEHLKLTFCG-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLRHLR---RPVALQLDHN-SVGDIG------- ------------------------VEQLL----PCLGACK----------ALYLRDN--- NISD-----RGICKLIEHAL------------------------------HCEQLQKLA- ------------------------------LFNNKLTDGCAHSVAQLLACK-QNFLALR- --LGNN-HITAEG----------------------------------------------- ---------------------------AQVLAEGLRDNSS-LQFL--------------- ----------------------------------------------G--XXXXXXXXXXX XXXXXXXXXXX------------------------------------------------- ------------------------------------------------------------ -XX--XXX--XXXXXXXXXXXXXXX---XXXXXXX-XXXXXXXLEE--NHLQDAGVCSLA EGLKR-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKVL--KLSNNCITFVGAEALLQALA---------- ---------------------------------------------------SNDTILEVW ------------------------------------------------------------ ---------------------------------------------LRGNP-FSP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEMEALSHRDSRL--LL----------------------------- ---------------------------------------- >G_gorilla_ENSGGOP00000010525 ------------------------------------------CEMCSQEAFQAQRSQLVE LL-VSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLL-------DTVWNK GTWACQKLIAAAQEAQADSQSPKL--------HGCWD--PHSLHPARDLQSHRPAIVRRL HSHVENMLDLAWERGFV------SQYECDEIRLPIFTPSQ----------RX-------- ------------------------------------------------------------ ------------------XXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX------- ------------------XXX--------XXXXXXXXXXXXXXXXXXXXXXXXXXX---- -XXXXXXXX---X------------XXX-------------XXXXXXXXXXXXXXXXXXX -XXXXXXX-X--------XXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX -XXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX-XXXXXX XXXXXXXXXXX--X-XXXXX----XRHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRP AAVSAFLRKYIR-TEFNLKGFSEQGIEL-YLR---KRHRE-----------------P-- -GVADRLIRLLQATSALHGLCHLPVFSWMVSKCHQELLL----QEG-------G-SPKTT TDMYLLILQHFLLH--ATP-PDSASQG-----LGPSLLRGRLPTLLHLGRLALWGLGMCC YVFSAQQLQAA--------------QVSPDDISLGF--LVHAKGVVP----GS----XAP LEFLHITFQCFFAAFYLALSADVPXALLRHLFNCG-RPGNSPM-AR-------------- -----L------LPTM-CIQGSEGKDSSVAALLQKAE----------------------- -------PHNLQITAAFLAGLLSREHWGLLAECQTS-EKAL-L-RRQACARWCLARSLRK HFHSIPPAAPG--EAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCS-- ------------------------------------------------------------ -----VGPAECAA----L-------AFVLQHLR---QPVALQLDYN-SVGDIG------- ------------------------VEQLL----PCLGVCK----------ALXXXXX--- XXXX-----XXXXXXXXXXX------------------------------XXXXXXXXX- ------------------------------XXXXXXXXXXXXXXXKLLACR-QNFLALR- --LGNN-HITAAG----------------------------------------------- ---------------------------AQVLAEGLRGNTS-LQFL--------------- ----------------------------------------------G--FWGNRVGXEGA QALAEALGDXQ------------------------------------------------- ------------------------------------------------------------ -SL--RWL--SLVGNNIGSVGAQAL---ALMLAKN-VMLEELCLEE--NHLQDEGVCSLA EGLKK-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKIL--XXXXXXXXXXXXXXXXXXXX---------- ---------------------------------------------------XXXXXXXXX ------------------------------------------------------------ ---------------------------------------------LRGNT-FSL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EEVDKLGCRDTRL--LL----------------------------- ---------------------------------------- >P_pygmaeus_ENSPPYP00000007971 ------------------------------------------------------------ ----------------------------------------------TEMDAPRP--PSLG VPGAASRPRRL----LDGRHGRQQVQA-----LSSQLLEVIPDSMKKQEVRTGREAGQGH GTGSPAEQVKALMDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQGSQ---APQAPDRTPDA---PLGPCSNDSRIQRHRRALLSKVGGVPEL------ -GRPWHRLA---S------------LLLVEGLTDLQ-LREHDFTQVEAT--RGGGRPART VALDRLFL-P--------LSR--VSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD -FSLVLPLTFRDLNT--------HEKLCADRLICSVFPHVG-----EPSLAVA--VPARA LLILDGLDECRTPL-DFSNT----VACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRP SASGQIPGGLVD-RMTEIRGFNEEEIRV-CLE---QMFPED----------------Q-- -ALLGWMLSQVQADRALYLMCTVPAFCRLTGAALGHLWR----SRTGPQDAELW-PPRTL CELYSWYFRMALSG--EGQ-ETGKASPR-----IEQVAHGGRKMVGTLGRLAFHGLLKKK YVFYEQDMKAF--------------GVDLALLQG-A--PCSCFLQRE----ETLAS-SVA YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-AYRTQVAELLQGCLR- ---------------PDAAVCARAINVLHCLHELQHTELARSMEEAME-S-GAL-ARL-- ------------------------------------------------------------ -----TSPAHRAA----L-------AYLLQVSD---ACA--------------------- -----------QEANLSLSLSQGVLQSLL----PQLLYCR----------KLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLL-VNRSLTSLDL RGN-SIGPQ-GAKALADALKINRTLTS-LSLQGNTIGDDGARSMAEALASN-RTLSMLH- --LQKN-SIGPMG-AQRMADALKQNRSLK------------------------------- -ELM-----------LSSNS--IGDGGGKALAEALKVNQG-LESL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DLRENSISPEGAQAI---AHALRAN-STLKNLDLTA--NLLHDQGARAIA VAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RTLTSL--HLQWNFIQAGAAQALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDDGACA- --------------------------------------------------------VARA LKVNTALTALYLQVASI------------------------------------------- -----------------------------------------GAPGAQVLGEALAVNRTLE ILDLRGNAIGVAGAKALANALKVNSSLRKLN----LQENSLEMDGAICVATALSGNHRLQ H-INLQGNHIGDSGARMISEAIKTNAPTCTVEM------- >G_aculeatus_ENSGACP00000012026 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------T-----------------LLLVDGLSDIQ-QKEHDLMQVGAT-RGRKRNHLRQ LGLTKLLE-P--------LTR--VSLPPRVSLTVGVAGIGKTTWVRHFVRQWSQGLICAD -VSFVLPFAVCELNS--------VEKVSAEKLVKLAFPHLT-----DPSVVLS--SSCRT LLILDGLDEFRCSA-NFADA----ASCSDPKKEVSIDDLVTNIIRGNLLPDAAVWVTCRP RVASLIPGGLVD-RVTEIPGFSPQDIRL-FLD---HHFSE-----------------R-- -DFGSKIWTHLESHKILMVMCYIPSVCWIVAETLVYIMR---------SETDES-LPRTC TELYAHFCSMKAEA---GE-PRGREPVK-----MEQLHGSNRKLLGNLGRLAFYGLLKHK YTFSEQDLRAY--------------GIDLLLGQG-S--LGTGVLVRE----ELAIC--TT YRFTHLTLQEFLAATFYHISSKRAIFDLFSESTMS------------------------- ----------------WPKIGFQNHFRSAFQHSQQAE----------------------- -------DGHLDVFVRFLTGLLSPAALKPLAGLLAV-GKDE-G-NQKAFAAGFLQGLLVG ---------------GGAVVSLRAVNLAYCLHELQHAELLRSVEEDLQ-L-GSL-AGK-- ------------------------------------------------------------ -----LTRAHCVV----L-------GYLLHVSP---ECS--------------------- -----------EQTNLTGSLNYATVKCLL----PQLLYCS----------YLRLENN--- HFKD-----DVMELLGSLLSAKDCHIQKMSLAENAIGNKGAKALSRALL-VNRTLTSLNL RNN-NIGSK-GTRFLAEALKMNQVLVS-INFQNNAIEEEGAQALAEVLHCN-RKLVSLN- --IRKN-TIGAGG-AKRIAEALKTNRTLT------------------------------- -KLI-----------LCSNQ--LGDRGAIALAEALAVNHT-LLSL--------------- ----------------------------------------------Q--LQSNSISNKGM TALTKALRLNR------------------------------------------------- ------------------------------------------------------------ -GL--VSL--NLRENSIGVEGAKNM---AHALHEN-NCLQELDLTA--NLLHDEGVQAIA GAIKF-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RGLTSL--HLQWNFIKCSATKALAHALL---------- ---------------------------------------------------SNGTMQLLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGNEGVIF- --------------------------------------------------------LAEA LKTNASLRTLCLQGVSA------------------------------------------- -----------------------------------------STSGAIAMAEALTTNRSLQ TLDLRGNAVGMEGAKALANALKSNRSLKSLN----LQENSLGMDGAIFIATALKGNHQLT Y-INLQGNGIGESGAKVISDAIRASASGCVVDI------- >O_latipes_ENSORLP00000009469 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------HQNQLRSFLTKPFLEEILTHLKKVDVLTLAEETTIK EAGQLKDQVTVLTTVIT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -SKESQGSD---ALQGFIMSSNAPVSQLILNYADSTVRRHKDVLLQQYEHYRERDSVSCS KLNICSRT-----------------LLLIDGLSDLQ-QKEHDLMQVGVT-RGRKVNHLRQ LGLGKLFE-P--------LTR--VSLPPRVSLTVGVSGIGKTTWVRHFIRQWSQGAVCSD -FHFVLPFTFSELNT--------LEKLSAEKLVKMAFPYLA-----DPSLVLT--SPCRT LLIFDGLDEFRCRL-NFSDA----IPCNDPKKEVSIDDLITNIIRGNLLPDVAVWVTSRP GVASLIPGGLVD-RVSEIPGFSPDDIQT-FLN---HHFSE-----------------R-- -DFASKIWAHLQAHSILMVMCYIPCICWITADTLLYILQ---------SGAQES-LPRTC TGLYAHFCYMKAEL---GE-PRGREPIK-----TEQFHGSNRKLLGNLGRLAFYGLLKHK YTFSEQDLKAY--------------GIDLQLTQS-S--LGAGVLIRL----ESTIH--TT YRFTHLTLQEFLAATFYHVSSKRAIFDLFSESTMS------------------------- ----------------WPKIGFQTHFRSAFQHSQQAE----------------------- -------DGHLDVFVRFLTGLLCPTALKPVAGLLAA-GKDD-G-NQKVWAAGFLQGLLSS ---------------GEAVVSLRIVNLAYCLHELQHTELLRSVEDDLR-Q-ESL-AGK-- ------------------------------------------------------------ -----LTRPHCVV----L-------GFLLHVSP---ECS--------------------- -----------DQTNLTGSLNYSTVKSLL----PQLLYCS----------HLRLENN--- NFKD-----DVMELLGSLLSAKDCHIQKLSLADNAISNKGAKALSRALL-VNRTLTYLNL RNN-NIGSK-GAKFLAEALKMNQVLTSKLSFQNNSIEEEGAQALAEVLQCN-RKLVSLN- --VRKN-KIGADG-AKRIADALKMNQTLT------------------------------- -KLI-----------LCSNQ--LGDKGTVALAEALKLNQT-LLSL--------------- ----------------------------------------------Q--LQSNSISNRGM TALTKALRFNH------------------------------------------------- ------------------------------------------------------------ -GL--VTL--NLRENSIGIEGAKNM---AQALKEN-NSLQNLDLTA--NLLHDEGVQAIS AAIKF-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QGLTSL--HLQWNFIKSTATKVLANALM---------- ---------------------------------------------------SNATIKLLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGNEGVIF- --------------------------------------------------------LAEA LKVNTSLQTLCLQGVSA------------------------------------------- -----------------------------------------GTSGAVALAEALMENQSLQ TLDLRGNSIGMEGAKALANALKCNRSLKSLN----LQENSLGMDGAIFIATALKGNHQLA Y-INLQGNGIGESGAKVISDAIRATALSCVVDI------- >T_nigroviridis_ENSTNIP00000015794 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------T-----------------LPLVDGISDLQ-QKEHDLMQVGVT-QGRKPSHLRQ LTLDKLLE-P--------LTR--VSLPPRVSLTVGVAGIGKTTWVRHFVRLWSQGAICPD -ISFVLPFTFCELNS--------LEKLSVERLVKMAFPNLM-----DARLVLN--SSCRT LLIFDGLDEFHGTL-NFSDV----APCCDPRKEVPIDELITNIIRGNLLPDVAVWVTSRP GVASLIPGGLVD-RVTEIPGLSSNDIQL-FLK---HHFSE-----------------R-- -EVEKKIWAHLESNKMLMVMCSIPCICWIIAETLTYIIQ---------SGTHES-LPKTC TELYAHFCSMKAEI---GE-PRGREPPK-----ME--HGSNRKLLGNLGRLAFYGLLKHK YTFSEQDLKAY--------------GIDLLLTQC-S--LCAGVLLRE----ESLIH--TT YRFAHLTLQEFLAATFYYASSKRAIFDLFSENTMS------------------------- ----------------WPKIGFQNHFKCAFHHSQQAE----------------------- -------DGHLDVFVRFLTGLLSPLTLKALSGLLVF-GKDD-G-NHKSWASGFLQGLLDG ---------------GGAIVSLRAVNLAYCLQELQHTELLRSVEDDLR-L-GSL-AGK-- ------------------------------------------------------------ -----LTRAHCVV----L-------GYLLHVSS---ECS--------------------- -----------EETNLSGCLNYTTVKCLL----PQLFYCS----------TLRLENN--- NFRD-----DVMELLGSLLSAKDCHIQKISLAENAITNKGAKALSRALL-VNRTLTSLNL RNN-NIGSK-GAKFLAEALKMNQALVL-LNLQSNGIEEAGAQALAEVLQCN-RKLVILN- --IQKN-AVGAAG-AKRIADALKTNRTLT------------------------------- -ELM-----------ICSNQ--LGDKGTVALAEALAVNHT-LLSL--------------- ----------------------------------------------E--LQSNSISNRGM AALTKALSLNR------------------------------------------------- ------------------------------------------------------------ -GL--ISL--NLRENSIGEEGARNM---AKALQKN-SSLRDLDLTA--NLLHDDGVQAIA AAVKT-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QGLRSL--HLQWNFIKSSAARALAHSLL---------- ---------------------------------------------------FNATMELLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGNEGVTF- --------------------------------------------------------LANA LKGNTSLRTLCLQGVSA------------------------------------------- -----------------------------------------GTSGAIALAEALAVNQTLQ TLDLRGNSVGMGGAKALANALKTNRSLKSLN----LQENSLGMDGAIFIATAFKENHQLT Y-INLQGNGIGESGAKVISDTIRGNTPGCMVDI------- >A_carolinensis_ENSACAP00000001490 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSGRLT---D------------LLLVEGLTDLQ-QKQHDFVQIETT--KGVRNASRK ISLEKLFL-P--------LSK--LSIPPRVSVTVGVSGIGKSTLVGLFVHAWGKGELGKD -FVFVLPLTFRELNA--------HDRLSAERLIRLASPRLA-----DRSLLSS-VDSSQT LLILDGLDEFKTRL-DFSNA----AVCTDLCKEVQVENLITNIIRGNLLQEVSVWITSRP TAASQIPGGLVD-RMTEIQGFGDADIKD-YLD---DMFIED----------------P-- -NLSESVMQHLKGNRPLYIMCTVPAFCKICGSSVGYFLK----SAKGSPEISA--VPKTL TEIYSHFFKMALCS--EGT-GKQNEVLR-----IEQVEQNCKKTMSCLGRLAFYGLIKKK FVFYEQDIKAY--------------GVDLSSLHI-G--LSNRLLMKE----EAPLS--TL YYFPHLTFQEFLAAAYYYTASKRALFDLFVESGMS------------------------- ----------------WPKLGFLNHFRNAVQKSLQSE----------------------- -------DGHLDVFVRFLAGLLSPQANKALSGWFLA-RDEH-H-SYRSHAVGLLQNFLG- ---------------LEQAVSCRTVNLMRCFHEIQNTELAGVIEEAMK-N-ENL-SGM-- ------------------------------------------------------------ -----LTPVNCSA----L-------AYVLQTSE---VCA--------------------- -----------EEANLSSCLTYPAFQSLL----SQLLYCN----------NLRLDYN--- QFKD-----NAMDLLGSILSGKDCQIQKISLAENQIGNKGAKALARSLM-VNRSLVALDL RSN-SIGPK-GAKAIADALKINQSLLS-LNLENNTMKEDGAKSLAEALVNN-HTLMTLQ- --LQKN-SIGPQG-SKKIAEALKKNWSLK------------------------------- -ELL-----------LSSNC--VGDVGAVALGEGLKINHS-LLTL--------------- ----------------------------------------------D--LQSNSISDAGA TALTRALCSNQ------------------------------------------------- ------------------------------------------------------------ -GL--TRL--SLRENSISPEGAREI---GIALQAN-RCLGNLDLAA--NLLHDEGVQAIA LALKA-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLASL--HLQWNFIQSNAAKTLSQALQ---------- ---------------------------------------------------FNNSLEVLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGIVA- --------------------------------------------------------LALA LRVNSTLTALYLQATLI------------------------------------------- -----------------------------------------GERGAVALGEALSVNKSLA VLDLRGNAIGLAGAKAMAGALKVNGTLRRLN----LQENLLGMDGAICIATALTRSHSLT Y-INLQGNRIGESGAKVITDAICTNAPGCRVEM------- >H_sapiens_ENSP00000301749 ------------------------------------------------------------ ----------------------------------------------MEMDAPRP--PSLA VPGAASRPGRL----LDGGHGRQQVQA-----LSSQLLEVIPDSMRKQEVRTGREAGQGH GTGSPAEQVKALMDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQGSQ---APQALDRTPDA---PLGPCSNDSRIQRHRKALLSKVGGGPEL------ -GGPWHRLA---S------------LLLVEGLTDLQ-LREHDFTQVEAT--RGGGHPART VALDRLFL-P--------LSR--VSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD -FSLVLPLTFRDLNT--------HEKLCADRLICSVFPHVG-----EPSLAVA--VPARA LLILDGLDECRTPL-DFSNT----VACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRP SASGQIPGGLVD-RMTEIRGFNEEEIKV-CLE---QMFPED----------------Q-- -ALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWR----SRTGPQDAELW-PPRTL CELYSWYFRMALSG--EGQ-EKGKASPR-----IEQVAHGGRKMVGTLGRLAFHGLLKKK YVFYEQDMKAF--------------GVDLALLQG-A--PCSCFLQRE----ETLAS-SVA YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-AYRTQVAELLQGCLR- ---------------PDAAVCARAINVLHCLHELQHTELARSVEEAME-S-GAL-ARL-- ------------------------------------------------------------ -----TGPAHRAA----L-------AYLLQVSD---ACA--------------------- -----------QEANLSLSLSQGVLQSLL----PQLLYCR----------KLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLL-VNRSLTSLDL RGN-SIGPQ-GAKALADALKINRTLTS-LSLQGNTVRDDGARSMAEALASN-RTLSMLH- --LQKN-SIGPMG-AQRMAD-LKQNRSLK------------------------------- -ELM-----------FSSNS--IGDGGAKALAEALKVNQG-LESL--------------- ----------------------------------------------D--LQSNSISDAGV AALMGALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--SLRENSISPEGAQAI---AHALCAN-STLKNLDLTA--NLLHDQGARAIA VAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RTLTSL--HLQWNFIQAGAAQALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDDGACA- --------------------------------------------------------VARA LKVNTALTALYLQVASI------------------------------------------- -----------------------------------------GASGAQVLGEALAVNRTLE ILDLRGNAIGVAGAKALANALKVNSSLRRLN----LQENSLGMDGAICIATALSGNHRLQ H-INLQGNHIGDSGARMISEAIKTNAPTCTVEM------- >T_guttata_ENSTGUP00000003992 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EPRVQKHLESLQSSCGNGLE------- -TGALQRLT---N------------LLLVEGLTDIQ-QKEHDILQVETT--KGLPSVSKS IPLEKLFL-P--------LSK--VSIPPRICVTIGVAGIGKSTLVKLFVCSWAKGEINRD -IMFVLPLTFRELNT--------YEKLSAERLICSAFPHIT-----EPGGIAA--GAART LLILDGLDEFKTPL-DFSNA----VVCTDPKKEIQVDNLITNIIRGNLLQEASVWVTSRP AAARQIPGGLVD-RMTEIRGFGAAEMKD-FLE---QMFPDN----------------R-- -DLSSQVLQHIRANRSLHVLCTIPGFCWISGSSIAYFLK----RSGDQSQEATV-VPRTL SEIFSYYFKMALSG--EWL-EKPREALR-----IEQAVNTSKKLVGSLGRLAFYGLLRRK HVFYEQDMKAY--------------GIDLSLLHS-C--LSTRLLLKE----DMQAS--TA YYFSHLTTQEFLAALYYYTAAKRAIFDLFTESGVS------------------------- ----------------WPKLGFLSHFRSAVQRALQAE----------------------- -------DRQLDIFIRFLSGLLSPRVNRLLAGWLLA-KDEQ-G-GFRSQAIGVLQGCLN- ---------------ADHAVSWRAVNAMRCLQEMQHTDTAEAVEEAMR-S-GSL-AGM-- ------------------------------------------------------------ -----LTPMNCSA----L-------AYLLQVSD---VCM--------------------- -----------EETNLSSCLTYNVCKSLL----SQLLFCH----------SLRLDNN--- QFKD-----DVMELLGSVLSGKDCQIQRLSLAENQISNKGAKALARSLL-VNRSLMVLDL RSN-SIGPT-GAKALADALKKNQILLS-LNLQHNSIKEDGATFLAEALLTN-HRLVTLH- --LQKN-GIGAQG-TRKMAEALKQNCSLR------------------------------- -ELI-----------LSSNS--VGDNGSIALAEALRVNHS-LQSL--------------- ----------------------------------------------D--LQSNSISSAGV TALTAALCSNK------------------------------------------------- ------------------------------------------------------------ -GL--LSL--NLRENSISKEGGPAI---ARALRSN-STLRKLDLAA--NLLHDDGGKAIA SAIGE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALTSL--HLQWNFIQAKAATALAQALQ---------- ---------------------------------------------------SNSSLASLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGVAA- --------------------------------------------------------LSAA LKVNTTLADLHLQVASV------------------------------------------- -----------------------------------------GVAGAQALAEALMVNKSLQ ILDLRGNSLGPAGAKAVANALKVNRSLRWLK----LQENSLGMDGAICIATALKGNHGLT TSSNLQGNRIGQSGAKMISDTIRSNSPDCVVDV------- >T_rubripes_ENSTRUP00000038883 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GG PAHPAPRT-----------------LLLVDGLSDLQ-QKEHDLMQVGVI-QGRKPNHLRQ LVLDKLLE-P--------LTR--VSLPPRVSLTVGVAGIGKTTWVRHFVRQWSQGAICPD -ISFVLPFTFCELNL--------LDKMSAERLVKIAFPHMV-----DASLFLN--SSCRT LLIFDGLDEFNGTL-NFSDV----APCSDPKKEVPIDELITNIIRGNLLPDVAVWVTSRP GVASLIPGGLVD-RVTEIPGLSSTDIQL-FLK---HHFSE-----------------R-- -EVDKKIWAHLESHKMLMVMCSIPCICWILAETLTYIIQ---------SETHES-LPKTC TELYAQFCSMKAEI---GE-PRGREPPK-----ME--HGSNRKLLGNLGRLAFYGLLKRK YTFSEQDLKAY--------------GIDSLLTQC-S--LGAGVVVRE----ESFIH--TT YRFTHLTIQEFLAATFYHASSKRAIFDLFSENTMS------------------------- ----------------WPKIGFQNHFKCAFQHSQQAE----------------------- -------DGHLDVFVRFLAGLLSPVTLKTLAGLLAV-GKDD-G-NHKTWASGFLQGILGS ---------------GGAVVSLRTVNLAYCLQELQHSELLRSVEEDLR-L-GSL-TGK-- ------------------------------------------------------------ -----LTRAHCVV----L-------GYLLHVSA---ECS--------------------- -----------KETNLPGCLNYSTVKCLL----PQLLYCS----------HLRLESN--- NFKD-----DVMELLGSLLSAKDCQIQKMSLAENAISNKGAKALSRALL-VNRTLTSLNL RNN-NIGSK-GARFLAEALKMNQALVS-LNLQSNGIDEAGAEALAEVLQCN-RKLVTLN- --MQKN-IVGAGG-AKRIADALKTNKTLT------------------------------- -ELM-----------ICSNQ--LGDKGTAALAEALTVNHT-LLSL--------------- ----------------------------------------------Q--LQSNSISNRGM TALTKALSLNR------------------------------------------------- ------------------------------------------------------------ -GL--VSL--NLRENSIGVEGARNM---AKALQKN-SSLQDLDLTA--DLLHDDGVQAIA AAIKN-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QGLRSL--HLQWNFIKSSATKALAHSLH---------- ---------------------------------------------------FNTTMELLD ------------------------------------------------------------ ---------------------------------------------LQENA-VGNEGVTF- --------------------------------------------------------LADA LKANTSLRTLCLQGVSV------------------------------------------- -----------------------------------------GTGGAIALAEALMSNQTLQ TLDLRGNSVGMEGAKALANALKTNRSLKSLN----LQENSLGMDGAIFIATAFKENHQLT Y-INLQGNGIGESGAKVISDTIRGNTPGCVVDI------- >O_anatinus_ENSOANP00000001675 ------------------------------------------------------------ -----------------------------------------------------VASPAPS PLAECLEGPGGRRPPPAPGSWLQRHQKQLLQAISSPLLDEILGYVRKQEVLTGEEAGKVC QATSLAGQVKALVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGTQGSW---ALQTFIENSDS-----QLCAADPTMQRHLEFLRKRFGSGPDPT----- -LSASQRLT---K------------LLLVEGLTDLQ-QKDHDFVQIEAT--RGGRQASKN IALERLFS-P--------LSK--VSIPPRVSVTVGVAGIGKSAVVKLYVGLWLQGEVGQD -IKWVLPLSFQELNA--------LDKLSADRLVRLASANAS-----EAAHC----GLARV LLILDGLDEFKTPL-DFSNA----VACTDPKKEIPVDGLVTNIIRGNLLPEASVWVTSRP TAAGQIPGGLVD-RMTEIRGFDKAEMED-YLN---RLFPES----------------P-- -DLAVRVLRQVGANPALYLLCTVPSFCRLCGVVLGCLLK----GRPDRQLPEAS-FPKSL SELYASYFKMALCG--DWP-DRPKESLR-----TEQA-ASGKKLLGALGRLAFFGLVKKR YVFSEPDLKAH--------------GVELSLLQA-N--PRHCLFLKE----EAQGS--VH YYFAHLSLQEFAAAVFYYCAAKRALFDLFSDNGMS------------------------- ----------------WFKLGFLTHYRNALQRALQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNRLLAGWLLV-KDEH-D-GHRGPVRDLLQDCLR- ---------------PMANVSSRMVNIVRCLQELQCPELAQSVEEAMA-S-ESL-AGK-- ------------------------------------------------------------ -----LTPLHRSA----L-------AYVLQVSE---ACA--------------------- -----------DETNLSRCLSHGDLESLL----AQILYCR----------NLRMDSN--- QFQD-----SVMELLASVLSGKDCLIEKLSLAENEISNKGAKALARSLM-VNRSLTTLDL RGN-SIGPQ-GAKALADALKINRVLMS-LNLQNNKIKDDGAKALAHVLSTN-NTLSVLH- --LQKN-SIGPIG-AKTLASALKQNRTLK------------------------------- -KLM-----------FSGNG--CGNEGSEALAEALKLNQG-LITL--------------- ----------------------------------------------D--LQSNSISNAGI LALTQALCSNK------------------------------------------------- ------------------------------------------------------------ -TL--INL--NLRENSIGSEGAREI---ASALRAN-RTLKDLDLAA--NLLREEGAQALA VAVKE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTLTSL--HLQWNFIQSSATKALAQALQ---------- ---------------------------------------------------FNRSLTSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000013154 ------------------------------------------------------------ ----------------------------------------------MEMDAPRP--PSLA VPGAALRPGRL----LDGGHGRQQVQA-----LSSQLLEVIPDSMRKQEVRTGREAGQGH GTGSPAEQVKALMDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQGSQ---APQALDRTPDA---PLGPCSNDSRIQRHRKALLSKVGGGPEL------ -GGPWHRLA---S------------LLLVEGLTDLQ-LREHDFTQVEAT--RGGGRPART VALDRLFL-P--------LSR--VSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD -FSLVLPLTFRDLNT--------HEKLCADRLICSVFPHVG-----EPSLAVA--VPARA LLILDGLDECRTPL-DFSNT----VACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRP SASGQIPGGLVD-RMTEIRGFNEEEIKV-CLE---QMFPED----------------Q-- -ALLGWMLSQVQADRALYLMCTVPAFCRLTGAALGHLWR----SRTGPQDAELW-PPRTL CELYSWYFRMALSG--EGQ-EKGKASPR-----IEQVAHGGRKMVGTLGRLAFHGLLKKK YVFYEQDMKAF--------------GVDLALLQG-A--PCSCFLQRE----ETLAS-SVA YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-AYRTQVAELLQGCLR- ---------------PDAAVCARAINVLHCLRELQHTELARSVEEAME-S-GAL-ARL-- ------------------------------------------------------------ -----TGPAHRAA----L-------AYLLQVSD---ACA--------------------- -----------QEANLSLSLSQGVLQSLL----PQLLYCR----------KLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLL-VNRSLTSLDL RGN-SIGPQ-GSKALADALKINRTLTS-LSLQGNTVRDDGARSMAEALASN-RTLSMLH- --LQKN-SIGPMG-AQRMADALKQNRSLK------------------------------- -ELI-------------------------------------------------------- -------------------------------------------------LQSNSISDAGV AALMGALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--SLRENSISPEGAQAI---AHALRAN-STLKNLDLTA--NLLHDQGARAIA VAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RTLTSL--HLQWNFIQAGAAQALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDDGACA- --------------------------------------------------------VARA LKVNTALTALYLQVASI------------------------------------------- -----------------------------------------GASGAQVLGEALAVNRTLE ILDLRGNAIGVAGAKALAHALKVNSSLRRLN----LQENSLGMDGAICIATALSGNHRLQ H-INLQGNHIGDSGARMISEAIKTNAPTCTVEM------- >B_taurus_ENSBTAP00000005918 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LSPQPLAAVPDSMRKQELRPGGETGQGH TASSPAEQVKALVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGGQGPQ---APQPPNRTPEC---PLKPRGNDLKIQKHREALLNRTGGGPEL------ -GSPSPRLT---S------------LLMVEGLTDLQ-LREHDFTQVEAT--RGRWCSAKT IALDRLFL-P--------LSR--VSIPPRISITIGVAGVGKTTLVRNFVHLWARGQVGKD -FSLVLPLTFRDLNT--------HEKLSADRLLRSVFPHTG-----EAGLASA--VLSKA LLVLDGLDECKTPL-DFSNT----VACMDPKKEIQVDHLITNIIRGNLFPEVSVWITSRP GAAGQIPGGLVD-RMTEIRGFSEEEIKT-CLE---QMFPED----------------P-- -VLTGWVLSQVQADRTLYLMCTVPAFCRLVGAALGHLHR----KRPGPPDAELW-PPRTL CELYSWYFRVALGG--EGQ-EKAKASPR-----IEQVAHGCRKLVGTLGRLAFHGLVRKK YVFYEPDLKVL--------------GVDLVLLQT-A--LCGRFLQRE----ETLAS-AAA YCFTHLSLQEFLAAAYYCSASKRAIFDLFTEGGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLT-QGEH-Q-GYQAQVAELLQGCLR- ---------------PDVAVCARAINVLHCLRELQHTELARSVEEAVA-S-GGL-ARL-- ------------------------------------------------------------ -----TSPPHRAA----L-------AYLLQVSD---VCA--------------------- -----------WEAPLPLCLSPGVLQSLL----PQLLYCR----------SLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQRISLAENQISNKGAKALARSLL-VNRSLTTLDL RSN-SIGPQ-GAKALADALKINRTLAS-LSLQSNRIRDDGARCMAEALATN-RTLSVLH- --LQKN-SIGPVG-TQQMADALKQNRSLK------------------------------- -ELM-----------FSSNS--IGDGGAKALAEALMVNQG-LKSL--------------- ----------------------------------------------D--LQSNSISDPGV AALMGALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--NLRENSISPEGAQDL---ARALRTN-STLKSLDLTA--NLLHDQGAQAVA EAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RTLTSL--HLQWNFIQAGAAKALGQALQ---------- ---------------------------------------------------LNTSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGASA- --------------------------------------------------------VASA LKVNTVLTALYLQVASI------------------------------------------- -----------------------------------------GAPGAQALGEALAVNRTLE ILDLRGNTIEVAGAKALASALKVNSSLQRLN----LQENSLGMEGAICVATALSGNHGLR H-INLQGNHIGESGARMISEAIKTNAPSCTVEM------- >M_domestica_ENSMODP00000020506 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------HLKQLLQAISSPLLEILGSMKKQEVVAEEEFSLVQ GAGSPTQKVKALIDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQGFQ---AGQDLTENSAA-----PLSLHNSGMQKHLEVLLSRYGVSVDLDLLSE- -KAASERLT---N------------LLLVEGLTDLQ-LKEHDFTQIEAT--RGQRRVAKT IPLERLFL-P--------LSK--VSIPPRISVTVGVAGIGKTTLVAQYVSKWARREISKD -ISLVLPLNFRELNI--------YEKLSAERLVRSVFPHIS-----ETGLTWL--GSGQV LMILDGLDEFKVAL-DFSNT----VACTDPKKEVPVDNLITNIIRGNLFPEVSIWVTARP TAASQIPGGLVD-RMTEIRGFNEVEIQA-YLS---QMFPDS----------------H-- -DLPGQVLSQVQANKALYLMCTVPSFCRLCGTVLGYLVR----NGLGCQSSELA-PPRTL SEIYSWYFKIALCG--EGQ-DRWRESPR-----IEQAVHSGRKMMGTLGRLAFHGLLRKK YVFYEQDMKAF--------------GVDLPLLQS-S--LCSCFLLRE----ETPTS--SA YCFIHLTLQEFAAAAYYYNAAKRAIFDLFTESGMS------------------------- ----------------WPKLGFLTHFKNAVQRASQED----------------------- -------NGQLDVFLRFLSGFLSPQVNSVLASWFLG-RDEH-N-SYRVQALAHLQGYLR- ---------------ADTPISSRTVNVLRCLHELQYTELARAVEEGLE-S-ENL-AGL-- ------------------------------------------------------------ -----LDPMHRSA----L-------AYLLQVSE---ICA--------------------- -----------QETNLTRCLNYAILKSLL----PQLLYCR----------NLRLDNN--- QFQD-----NVMELLGSVLSSKDCYIQKISLAENQIHNKGTKSLARSLL-VNRSLTVLDL RSN-SIGPQ-GAKALADSLKINRVLVS-LSLQNNAIKDDGAKFVADALMVN-HKLSVLQ- --LQKN-TIGPLG-AKSIADALKKNGSLK------------------------------- -ELI-----------FSSNS--VGNDGSKALAEALKVNQS-LITL--------------- ----------------------------------------------D--LQSNSISDAGV TALTHALRSNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--NLRENSISPEGARDI---ASALCSN-RVLQNLDLTA--NLLQDEGAQAIA LAVKE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALKSL--HLQWNFIQANAAKALGQALQ---------- ---------------------------------------------------SNRSLTILD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGMMA- --------------------------------------------------------LSRA LKINTSLTALYLQVASI------------------------------------------- -----------------------------------------GVLGAQALGDALAVNRTLE ILDLRGNSIGADGAKAMANALKINPSLQMLN----LQENSLGMDGAICIATALSGNHGLQ H-VNLQGNHIGESGARMISEAIKTNAPNCIVEM------- >C_familiaris_ENSCAFP00000028433 ------------------------------------------------------------ ----------------------------------------------SEAGPPRPSGPSRA GLRTTSRPGRAQRGSLPGPLGSLPAQARRVTRLSPQLPAAIPDPMRKQEVRPGAEAGQGC GSGSPAGQVKALVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GRSSQGSQ---TPQAPDRPPLGDALPFGLCPTGSRTQKCQEALLNWVKGSLEL------ -GGPPSRLT---S------------LLLVEGLTDLQ-LKEHDFTQVETT--RGGWHPART IALDRLFL-P--------LSR--VSIPPRISITIGVAGVGKTTLVRNFVYLWARGQVGKD -FSLVLPLTFRDLNT--------HEKLSADRLVHSVFPHTG-----ESGLAAA--APSKV LLILDGLDECKMPL-DFSNT----VACTDPKKEIQVDHLITNIIRGNLFPEVSVWVTSRP NVAGQIPGGLVD-RMTEIRGFNEDEIKV-CLE---EMFPED----------------H-- -TLSGWVLRQVQADRALYLMCTVPAFCRLAASALAHLSR----SKLGPQDAEPW-APRTL CELYSCYFRMALGG--DGQ-EKGKASPR-----IEQVAHSSRKMVGTLGRLAFHGLVRKK YVFYEQDLKAF--------------GVDLTLVQS-A--LCGCFLQRE----ETLAS-STA YCFSHLSLQEYVAAAYYYSASKRAIFDLFTEGGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-GYRAQVAELLQGCLR- ---------------PNVAVCARAVNILHCLHELQCTELARSVEEAME-S-GGL-AGL-- ------------------------------------------------------------ -----TGPQHRAA----L-------AYLLQVSD---ACA--------------------- -----------QEANLSLCLSRSVLQSLL----PQLLYCR----------SLRLDNN--- QFQD-----PVMELLGSVLSGKDCRIQRISLAENQISNKGAKALARSLL-VNRSLTALDL RSN-SIGPQ-GAKALADALKINRTLAF-LSLQSNEIRDNGARSMAEALATN-RTLSVLH- --LQKN-TVGPVG-AQLMAETLKQNRSLK------------------------------- -ELI-----------FSSNS--IGDGGAEALAKALRVNQG-LENL--------------- ----------------------------------------------D--LQSNSISDTGV AALMGALCANQ------------------------------------------------- ------------------------------------------------------------ -AL--TSL--NLRENSISPEGAREL---ARALRSN-STLKNLDLTA--NLLHDQGAQAIA VAMRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QALTSL--HLQWNFIQAGAAKALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGASA- --------------------------------------------------------VASA LKTNATLTALYLQAASI------------------------------------------- -----------------------------------------GARGAQALGDALAVNGTLE ILDLRGNAIGVAGAKALANALKVNSSLRRLN----LQENSLGMDGAICVATALSGNHGLQ H-INLQGNHIGESGARMISEAIKT-VPSCGLGM------- >E_caballus_ENSECAP00000013098 ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MRKQEVRTGGETGQGH SASSPAEQVKALVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGGQGSL---APQTPDRALDS---PLGPHSNDWRIQKHREALLSRVRGSPEL------ -GSPSPRLS---S------------LLLVEGLTDLQ-LKEHDFTQVEAT--RGGWRSTKT IALDRLFL-P--------LSR--VSIPPRISITIGVAGVGKTTLVRDFVCLWARGQVGKD -FSLVLPLSFRDLNP--------HEKLSADRLVRSVFPHIG-----ELGLAGA----TRV LLILDGLDECKTPL-DFSNT----VACTDPKKEIQVDHLITNIIRGNLFPEVSVWVTSRP SAAGQIPGGLVD-RMTEIRGFNDEEIQV-CLE---QLFPED----------------Q-- -VLLGWVLSQVQADRALYLMCTIPAFCRLTGLALGHLCR----NKPEPQDTELW-PPRTL CELYSWYFRMALGG--EGQ-EKGKASPR-----IEQLAHGGRKMVGTLGRLAFHGLVKKK YVFYEPDLKAF--------------GVDLALLQS-A--LCSCFLQRE----ESLAS-SAA YCFTHLSLQEFVAATYYYSASKKAIFDLFTEGGVS------------------------- ----------------WPRLGFLTHFRGAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-GYRAQVAELLQGCLR- ---------------HDTAVCARAINVLHCLHELQHTELARGVEEALE-S-GGL-ARL-- ------------------------------------------------------------ -----TGPHHRTA----L-------AYLLQVSD---TCA--------------------- -----------QEVNLSLHLSQGVLQSLL----PQLLYCR----------SLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQRISLAENQISNKGAKALARSLL-VNRSLTTLDL RSN-SIGPQ-GAKALADALKINRTLAS-LSLQSNTIRDDGARSIAEALGTN-RTLSVLH- --LQKN-TIGPVG-TQRMADALKQNKSLK------------------------------- -ELM-----------FSSNS--MGDGGAKALAEALKVNQG-LENL--------------- ----------------------------------------------D--LQSNSISDAGV AALMGALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--NLRENSISPEGAQDL---AHALCTN-STLKNLDLTA--NLLHDEGAQAIA VAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALTSL--HLQWNFIQAGAAKALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGASA- --------------------------------------------------------VASA LKANTALTALYLQVASI------------------------------------------- -----------------------------------------GAPGAQALGEALAVNRTLE ILDLRGNTIGVAGAKALANALKVNSSLRRLN----LQENSLGMDGAICVATALSGNHGLQ H-INLQGNHIGESGARMISEAIKTNAPSCTVEM------- >R_norvegicus_ENSRNOP00000032675 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VLALSSQLLAATQDSMRKQEVWTDRETCWAK NAGSPAEQVKTLVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQLLL---AYLVLCTSHFA---PYLFCPAESRLQKHCEALLSRVGNDPEL------ -GSPSHQLA---S------------LILVEGLTDLQ-LKEHDFTQVEAA--RGVWRPGRA ITLDRLFL-P--------LSR--VSIPPRVSVTIGVAGVGKTTLVRHFVRCWARGQVGKG -FSWVLPLTFRDLNT--------YEKLSADKLIYSIFSNAG-----EAGAVT---APDRA LLVLDGLDECKTPL-EFSNT----VACTDPKKEIQVDHLITNIIRGNLFPEISVWITSRP SAAGQIPGGLVD-RMTEIRGLTEEEIKV-CLE---QMFPED----------------Q-- -NLLGQVLSQVQANRGLYLMCTIPAFCRLTGLALGHLYR----TRLAVQDAELP-LPQTL CELYSWYFRMALGG--EGQ-DKGKVSPR-----IEQVMQGARKMVGTLGRLAFHGLVKKK YVFYEQDMKAF--------------GVDLALLQS-S--LCSCLLQRE----ETLAS-SVA YCFTHLSLQEFMAATYYYSASKRAIFDLFTESGMS------------------------- ----------------WPRLGFLTHFRCAVQRATQAK----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-SYRNQVAEVLQGFLH- ---------------PDTAVCARAINILYCLSELRHTDLARSVEEAMR-S-GTL-AGM-- ------------------------------------------------------------ -----TSPPHRTA----L-------AYLLQMSD---ICS--------------------- -----------WEADFSLCLSQRVLQSLL----PQLLYCQ----------SLRLDNN--- QFQD-----PVMELLGSVLSGKDCRIQKISLAENQIGNKGARGLARSLL-VNRSLVTLDL RSN-SIGPQ-GAKALADALKINRTLTS-LSLQSNVIKDDGVMYMAEALVSN-QIISTLQ- --VDV--TLRPRG-AQQMADALKKNRSLR------------------------------- -ELM-----------FSSNT--IGDRGAMALAEALKVNQG-LENL--------------- ----------------------------------------------D--LQSNAISNTGV AVLMRALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--SSL--NLRENSISPEGAQAL---AQALCRN-TTLKHLDLTA--NLLHDQGAQAIA TAVGE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CSLTHL--HLQWNFIQAGAARALGQALQ---------- ---------------------------------------------------LNRTLTTLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGASS- --------------------------------------------------------VAGA LKVNTTLTALYLQVASI------------------------------------------- -----------------------------------------GSQGAQALGEALAVNRTLE ILDLRGNDVGVAGAKALANGLKLNSSLRRLN----LQENSLGMDGAIYVATALSENHGLH H-INLQGNPIGESGARMISQAIEKNAPTCTVEM------- >H_sapiens_ENSP00000375653 ------------------------------------------------------------ ----------------------------------------------------MLRTAGRD GLCRLSTYLEELEAVELKKFKLYLGT--------ATELGEGKIPWGSMEKAGPLEMAQLL ITHFGPEEAWRLALSTF------ERINRKDLWERGQREDL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRDTP PGGPSSLGN---QSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGEC------ -VNLSHRYT----------------RLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASP IKIETLFE-P--------DEE--RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQG RFDYLFYINCREMNQ-------SATECSMQDLIFSCWPEPS-----APLQELI-RVPERL LFIIDGFDELKPSF-HDPQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLE----GG----GLLRQ-TSRTT TAVYMLYLLSLMQP--KPG----------------APRLQPPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGEDVSA-F--LNMNIFQKD----I---NCERY YSFIHLSFQEFFAAMYYILDEGEGGAG--------------------------------- ---------------------PDQDVTRLLTEYAFSE----------------------- -------RSFLALTSRFLFGLLNEETRSHLEKSLC--WKVS-P-HIKMDLLQWIQSKAQS ---------------DGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQ-V-IVV-SNI-- ------------------------------------------------------------ -----ASKMEHMV----S-------SFCLKRCR---SAQVLHLYGA-TYSADGEDRARCS AGAHTLLVQLRPERTVLLDAYSEHLAAAL----CTNPNLI----------ELSLYRN--- ALGS-----RGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI-ANKNLTRMDL SGN-GVGFP-GMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTN-PHLVELD- --LTGN-ALEDLG-LRLLCQGLRHPVCRL------------------------------- -RTLW----------LKICR--LTAAACDELASTLSVNQS-LREL--------------- ----------------------------------------------D--LSLNELGDLGV LLLCEGLRHPT------------------------------------------------- ------------------------------------------------------------ CKL--QTL--RLGICRLGSAACEGL---SVVLQAN-HNLRELDLSF--NDLGDWGLWLLA EGLQHPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQKL--WLDSCGLTAKACENLYFTLG---------- ---------------------------------------------------INQTLTDLY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGDTGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KRLSHPGCK---LRVLW----LFGMDLNKMTH-SRLAALRVTKPYL DIGC------------------------------------ >M_musculus_ENSMUSP00000094031 ------------------------------------------------------------ ------------------------------------------------------------ ----MQAEPFSTLEQPPWQEGDNIGSPGSVLALYSQLLAANTDSTRKQEVWTDRETCLAY SVGSPAEQVKALVDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQ------LLQVRDKMPDS---PLGSQSNESRIPKHSEALLSRVGNDPEL------ -GSPSHRLA---S------------LMLVEGLTDLQ-LKEHDFTQVEAT--RGVWHPARV ITLDRLFL-P--------LSR--VSIPPRVSLTIGVAGVGKTTLVRHFVHCWARGQVGKG -FSRVLPLTFRDLNT--------YEKLSADRLIQSIFSSIG-----EASLVAT--APDRV LLVLDGLDECKTPL-EFSNT----MACSDPKKEIQVDHLITNIIRGNLFPEISVWITSRP SAAGQIPGGLVD-RMTEIRGLTEEEIKV-CLE---QMFPEE----------------Q-- -NLLGQVLSQVQANRALYLMCTVPAFCRLTGLALGHLYR----TRLAVQDIELP-LPQTL CELYSWYFRMALGG--EGQ-DKEKVSPR-----IKQVTQGARKMVGTLGRLAFHGLVKKK YVFYEQDMKAF--------------GVDLALLQN-T--LCSCLLQRE----ETLAS-SVA YCFIHLSLQEFVAATYYYSASKRAIFDLFTESGMS------------------------- ----------------WPRLGFLAHFRCAAQRATQAK----------------------- -------DGRLDVFLRFLSGLLSPRVNTLLAGSLLS-QGEH-Q-SYRDQVAEVLQGFLH- ---------------PDAAVCARAINVLYCLSELRHTELACSVEEAMR-S-GTL-AGM-- ------------------------------------------------------------ -----TSPSHRTA----L-------AYLLQMSD---ICS--------------------- -----------PEADFSLCLSQHVLQSLL----PQLLYCQ----------SLRLDNN--- QFQD-----PVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLL-VNRSLITLDL RSN-SIGPP-GAKALADALKINRTLTS-LSLQSNVIKDDGVMCVAEALVSN-QTISMLQ- --LQKN-LIGLIG-AQQMADALKQNRSLK------------------------------- -ALM-----------FSSNT--IGDRGAIALAEALKVNQI-LENL--------------- ----------------------------------------------D--LQSNSISDMGV TVLMRALCSNQ------------------------------------------------- ------------------------------------------------------------ -TL--SSL--NL----MSPQPARKL---HQPRGSP-------GPHS--SSLQEQHSEALG PDS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >G_gallus_ENSGALP00000012708 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LQSFYGNSLE------- -IGSLQRLT---N------------LLLVEGLTDIQ-QKEHDILQMEMT--KGLRNVSKS IPLEKLFL-P--------LSK--VSIPPRISVTTGVAGIGKSTLVKLFVGRWTKGLINRD -IMFVLPLTFRELNT--------YEKLSAERLIRSSFPHIT-----EPNCIST--GAART LLILDGLDEFKTPL-DFSNT----VACTDPKKEIQVDNLITNIIRGNLLQEASIWVTSRP TAASQIPGGLVD-RMTEIRGFRATEMKD-FLD---QMFLDN----------------K-- -DLSGQVLHHIKANRSLHIMCTVPGFCRIYGSSIGYYLK----NSTGQPQEMTV-APKTL SEIYSYYFKMALSS--DWP-ERQRETLR-----IEQAVNNSKKVMGSLGRLEGYGLLKRK HVFF-RDMKAY--------------GIDLSLLHSRX--XXXXXXXXX----XXXXX--XX XXXXHLTIQEFLAAIYYYTAAKRAIFDLFTESGMS------------------------- ----------------WPKLGFLNHFKSAVQRSLQAE----------------------- -------DGQLDIFVRFLSGLLSPQVNQLLSGWLLV-KDEH-N-SYRSQAISFLQGCLN- ---------------TNYVISSQTVNTVHCLHEIQHTEIAKAVEEAMK-N-ESL-AGM-- ------------------------------------------------------------ -----LTPVNCSA----L-------AYLLQVSD---VCV--------------------- -----------EETNLSNCLTYNICKSLL----PQLLFCH----------SLRLDNN--- QFKD-----NVMELLGSMLSVKDCQIQRLXXXXXXXXXKGAKALARSLM-VNRSLTVLDL RSN-SIGPS-GAKALADALKKNQVLLS-LSLQHNVIKEEGAAALAEALLTN-RRLITLH- --LQKN-SIGAHG-ARKLAEALAQNCSLK------------------------------- -ELM-----------LSSNS--VGDNGSVALAEALKVNHS-LQSL--------------- ----------------------------------------------D--LQSNSISNTGV SALTAALCSNK------------------------------------------------- ------------------------------------------------------------ -GL--TDL--NLRENSISKEGGPAI---AHALRTN-CTLRKLDLAA--NLLHDEGGKAIA LAMKE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALTSL--HLQWNFIQTQAAVALAQALQ---------- ---------------------------------------------------SNDSLASLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDEGMAA- --------------------------------------------------------LAAA LKVNTTLADLHLQVASI------------------------------------------- -----------------------------------------SAAGAQALAEALMVNNSLQ VLDLRGNSISVAGAKAMANALKVNRSLRWLN----LQENSLGMDGAICIATALRGNHGLT Y-VNLQGNRIGQSGAKMISDAIRTNSPDCVV--------- >D_rerio_ENSDARP00000082345 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LGLDKLIA-P--------LTR--VSTAPRVTLTVGVAGSGKSRMVSRFIRLWSSGQIYPE -LSLAIPIACWELSS--------YDRISVERLLRLFVPYDN-----MDVIIFN--ESCKV LLILDGLEEFRQTL-DFADA----PPTSDPRREIPVSDLIANIVRGNLLPG--------- ---------LVD-RVTEAPPLSQTQIKD-YTN---HCITNALDVYSLESSSSQTDIPQ-- -DLSSQVWTYLNSQKLLLILSSVPAICHVIVTTLSRLIK--------IESEATP-LPRTL TEVYAHYCWPHLSK--------------------SDTASGIRKSLNTLGRLAFYSLLRRR YTFVESELRTY--------------GVDVPPQVG-T--LSYRILQRK----QSWSSDNKA WQFTHTSVQEFLGALYYYVSSRRAVFDLFSESGVS------------------------- ----------------WPRIGFHSHYRAALQKTNQSD----------------------- ----ATLQGSLDLFMRFLSGLLSPTAGVLLGGPLGV-SREE-QVTQRTTAMTLLQNAVAA A--------------GGDAVSMRSVNMVTCLAELQQGEWLRSIEEDLI-S-CGL-RGK-- ------------------------------------------------------------ -----LKGGVCAV----L-------AYLLLVSD---SCT--------------------- -----------EETQLSNCLDSSSLKRLL----PQLLYCS-------------------- --------------------------------------------------------KLSL RGN-NIGAK-GAKTLCEALKLNQFLVS-VNLQNNHIEDEGARSLSEVLQSN-RKLTTLN- --VQKN-GIGPEG----------------------------------------------- ---------------------------MKKIAEGLIKNQT-LQDF--------------- ----------------------------------------------N--LQSNSVSDRGI KALSHALQSNR------------------------------------------------- ------------------------------------------------------------ -GL--CCL--NLRENSIGVAGAKDI---AKALKVN-TCLRELDLTA--NLLHDEGVTAIA EAMRV-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RSISSL--HLQWNFMKAGAAKALAESLS---------- ---------------------------------------------------SNTC----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000019647 ------------------------------------------------------------ ----------------------------------------------------MLRTAGRD GLCRLSTNLEELEAVELKKFKLYLGT--------ATELGEGKIPWGRMKKAGPLEMAQLL ITHFGPEEAWRLALSTF------ERINRKDLWERGQREDL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRDTP PGGPSSLGN---QSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGEC------ -VNLSHRYT----------------RLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASP IKIETLFE-P--------DEE--RPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQG RFDYLFYINCREMNQ-------SATECSMQDLISGCWPEPS-----APLQELI-RVPERL LFIIDGFDELKPSF-HDAQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLE----GG----GLLRQ-TSRTT TAVYMLYLLSLMQP--KPG----------------APRLQPPPNQRGLCSLAADGIWNQK ILFEEQDLRKH--------------GLDGEDVSA-F--LNMNIFQKD----M---NCERY YSFIHLSFQEFFAAMYYILDEGERGAG--------------------------------- ---------------------PDQDVTRLLTEYAFSE----------------------- -------RSFLALTSRFLFGLLNEETRSHLEKSLC--WKVS-P-HIKMDLLQWIQSKAQS ---------------DGSTLQQGSLEFFSCLYEIQ-KEFTQQALSHFQ-V-IVV-SNI-- ------------------------------------------------------------ -----ASKMEHMV----S-------SFCLKHCR---SAQVLHLYGA-TYSADGEDRARCS AGTHTLLVQLRPERTVLLDAYSEHLAAAL----CTNPNLI----------ELSLYRN--- ALGS-----RGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI-ANKNLTRMDL SGN-GVGFP-GMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTN-PHLVELD- --LTGN-ALEDLG-LRLLCQGLRHPVCRL------------------------------- -RTLW----------LKICR--LTAAACDELASTLSVNQS-LREL--------------- ----------------------------------------------D--LSLNELGDLGV LLLCEGLRHPT------------------------------------------------- ------------------------------------------------------------ CKL--QTL--RLGICRLGSAACEGL---SVVLQAN-HNLRELDLSF--NDLGDWGLWLLA EGLQHPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQKL--WLDSCGLTAKACKNLYFTLG---------- ---------------------------------------------------INQTLTDLY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGDTGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KRLSHPGCK---LRVLW----LFGMDLNKMTH-SRLAALRVTKPYL DIGC------------------------------------ >G_gorilla_ENSGGOP00000016187 ------------------------------------------------------------ ----------------------------------------------MEMDAPRA--PSLG VPGAASRPGRL----LDGGHGRQQVQA-----LSSQLLEVIPDSMRKQEVRTGREAGQGH GTGSPAEQVKALMDLLA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -GKGSQGSQ---APQALDRTXDA---LLGPCSNDSRIQRHRKALLSKVGGGPEL------ -GGPWHRLA---S------------LLLVEGLTDLQ-LREHDFTQVEAT--RGGGRPART VALDRLFL-P--------LSR--VSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD -FSLVLPLTFRDLNT--------HEKLCADRLICSVFPHVG-----EPSLAVA--VPARA LLILDGLDECRTPL-DFSNT----MACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRP SASGQIPGGLVD-RMTEIRGFXEEEIKV-CLE---QMFPED----------------Q-- -ALLGWMLSQVQADRALYLMCTVPAFCRLTGAALGHLWX----SRMGPQDAELW-PPRTL CELYSWYFRMALXG--EGQ-EKGKASPR-----IEQVAHGGRKMVGTLGRLAFHGLLKKK YVFYEQDMKAF--------------GVDLALLQG-A--PCSCFLQRE----ETLAS-SVA YCFXHLSLQEFVAAXYYYGASRRAIFDLFTESGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-AYRTQVAELLQGCLR- ---------------PDAAVCARAINVLHCLHELQHTELARSVEEAME-X-GAL-ARL-- ------------------------------------------------------------ -----TGPXHRAA----L-------AXLLQVSD---ACA--------------------- -----------QEANLSLSLSQGVLQSLL----PQLLYCR----------KLRLDTN--- QFQD-----PVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLL-VNRSLTSLXX XXX-XXXXX-XXXXXXXXXXXXXXXXX-XXLQGNTVRDDGARSMAEALASN-RTLSMLX- --XXXX-XXXXXX-XXXXXX-XXXXXXXX------------------------------- -XXX-----------LSSNS--IGDGGAKALAEALKVNQG-LESL--------------- ----------------------------------------------D--LQSNSISDAGV AALMGALCTNQ------------------------------------------------- ------------------------------------------------------------ -TL--LSL--SLRENSISPEGAQAI---AHALXAN-STLKNLDLTA--NLLHDQGARAIA VAVRE-N----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RTLTSL--XXXXXXXXXXXXXXXXXXXX---------- ---------------------------------------------------XXXXXXXXX ------------------------------------------------------------ ---------------------------------------------XXXXX-XXXXXXXX- --------------------------------------------------------XXXX XXXXXXXXXXXLQVASI------------------------------------------- -----------------------------------------GAPGAQVLGEALAVNRTLE ILDLRGNAIGVAGAKALANALKVNSSLRRLN----LQENSLGMDGAICIATALSGNHRLQ H-INLQGNHIGDSGARMISXAIKTNAPTCTVEM------- >B_taurus_ENSBTAP00000051805 ------------------------------------------------------------ ---------------------------------------------------------LRS DLGRLCTYLEELEAVELKKFKLYLGT--------ATEMGEGKIPWGRMEQAGPLEMAQLL AAHFGPQEAWLLALSVF------HQINRKDLWERGHREDQ-------------------- ------------------------------------------------------------ ------------------------------------------DPWATLHLVAHPHWAASQ HVLWTSWLP---LREKVSHEVLHSSPLDPQETYRDYVRRKFRLMEDRNARLGEF------ -VNLSHRYT----------------RLLLAKEHSSPRWAQQKLLDTGRGHAGTAGHPASL IQIEALFE-P--------DEE--RPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGKLFQN RFDYVCYINCREMNR-------GTAELSVRDLLASCWPEPC-----APLQELV-RVPERL LVIMDGFDELRPSF-HEPQG----PWCLCWEKKAPAEVLLGSLIRKKLLPELSLLITTRP TALAKLQRSLEHPRHVAILGFSEAERKE-YFH---RYFHD-----------------R-- -EQASQVFSFVRDDEPLFTLCFVPMVCWVVCTCLKQQLE----GG----GLLRR-RSRTT TAVYLLYLLSLMQP--KPG----------------TPTLPSPPNRRGLCALAAHGLWEQK ILFAERDLREH--------------GLDAADVSS-F--LNMNIFQKD----I---ICETL YSFIHLSFQEFFAAMHYVLDDGASGSG--------------------------------- ---------------------PERNLSRLLTEYAFSD----------------------- -------RSFLALTVRFLFGLLNEETRSYLEKTLG--WKVS-P-GVKTELLEWIRRKARS ---------------EGSTLKQGALEVFGCLYELQEEEFIQQALSHFQ-V-VVV-NNI-- ------------------------------------------------------------ -----TTKMEHMV----S-------SFCVKSCR---NAEVLQLFGA-AYQAHGEDREDRR D--------------------------------KTTPNEI-------------------- ------------TWLFSSLR--------LRLKRCQVSSSVCQDLTTALI-ANKHLLRMDL SGN-ALGLL-GAQLLCQGLRHPKCRLQVVQLRKCHLEAGACQELASVLSTS-RHLLELD- --LTGN-ALEDSG-LRLLCQGLRHPVCRL------------------------------- -RILW----------LKICL--LTGAACEDLASTLHMNQS-LVEL--------------- ----------------------------------------------D--LSLNDLGDPGV LLLCEGLRHPQ------------------------------------------------- ------------------------------------------------------------ CKL--QTL--RLCICRLSSVACEGL---SAVLGVS-SHLRELDLSF--NDLGDRGMSLLC EGLRHPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQKL--WLDSCSLTGKACEDISSALG---------- ---------------------------------------------------INQTLTDLY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGNTGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ERLSHPGCK---LRVLW----LFGMDLNKMTH-RSLEALRMTKPYL DVGCLENW-------------------------------- >B_taurus_ENSBTAP00000007129 ------------------------------------------------------------ -----------------------------------------MDPVSL-------QLGTKN LHGYLVRLLSRNLGWLDAKVKLFLPSVDLGSGYQALDPTQRVILQLQKLHAQGPTTWKSF IQCVCMELDVPMDMEVL------LMSTWGHEDGFSSLLEI-------------------- ------------------------------------------------------------ ------------------------------------------------DEESQSDSQLHP GLKRTHQSC---GSSP-RPKQFRKQQQELAKRYLQLLRTSAQQRYGNRTPGPGQP----- -LAFHQAYV---P------------PILKWSRASAPFHTQEGATTGNPKAED-----GTD VNVRDLFSTK-------------ASKGPRVTVLLGKAGMGKTTLAHRLCQKWADGQLDR- -FQAVFLFEFRQLNL-------ITGSLTLPQLLFDMYLRPEASPE-AVFQHLK-ENAEGI LLIFDGLDEILQPCSD--------KETEDPEDPASALTLFSRLCRGTLLPGCSVMATSRP GKLPACLPTEA--ATVHMWGFDGPRVEE-YVN---HFFSD-----------------Q-- -PSQEAALAELQMDRHLWSMCAVPALCRVACLCLHHLLP------GRSRGQSAA-LLPTM TQNYMQMLLTLNPQ-----------------------GVLRAEPLLGLGEVALSGLESGK VIFSAGDIPAS--------------TLDFGAALG-L--LTSFCVCLG------PGHRDTG YAFSHLSLQEFFAALHLLASPQVDREALSQHVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------LGLSDHLPTFLAGLASRACRSFLSLLAER-EEEW-VAAKQEVVLQALKKLA-- ---------------TRRLTGPKVVELCHRVGETQDPELASFMARSLPQQ-LPFHNFL-- ------------------------------------------------------------ -----LTYADLAS----L-------TSILGHRD---GPIHLDFEGC-PLEPR-------- ------------------------CPETL----AGCGQVE----------NLSFKSR--- KCGD-----AFAEALSKSLP------------------------------TMGSLKKLGL AGS-KITAQ-GISHLVQALPFCP-QLEEVSFQDNQLKDREVLNIVEVLSCL-PRLQKLD- --LSRN-NVSVSTLLSLTKVAVTCPTIRMLQVRETDLIFLLSPPTETDPELQGDPDLQGN ANQRKEAQRRSLALRLQKCQ--LGVHDVEVLIAQLREGPQ-LDEV--------------- ----------------------------------------------D--LSGNQLKDKGC QLMAEAAPQLHITKKLDLSDNELSVAGVLGVLSVVNTYQTLTELHISLLHKTVVFTFAPE LEEQEGI----QKRATFPDS--LMFQMSSEPSLRSPRIRLTHCALQAQRLELLCKALGGS CRL--SHL--DLSGNALGDEGVALL---ARLLPGL-GSLQSLNLSE--NHLSLEGVCSLT QCFSTLRWLLHLEFSSASQHVILRG-----DKRGRDLLAAGSLPEFRAGAR-LGSGQRHV PRSFCLKECQLEPLSLSYLCKSLEKCPGPLEVQLSCEVLSDQSLETLLYHLPQLPQLSLL QLSQMQLPPESPLLLADLFSLCPQVQKVDLRSLRHLTLHLRSSEEQEDRCCCRFTDCGLR QEHVEPLCGLL-SKCEDLHQLDLSANLLGDDGLRCLLECLPKVPISGSLDLSHNSMSQES VLCLVEALPSCPRLREASVNLGSKQSFWIHFSRQEETGKTLRLSECHFKPEHMPRLAASL SQALQLTELTLTWCFPGLEQLTVLLGLLTWPTGVLTLR----VEEPWVGRVGVLTLLEVC AQASGNITGISISETQKQLCIQLEFPHQ-ENPEAVALRLAHCDLGTQQNLLARKLMETCA RLRQLSLSQVNLC---DASSLLLQSLLLSLSELKNFRLTSSCVSSKGLALLTSGLSHCHL LEELDLSNNQLGDEGTKVLLGALEGKCRLKRLDLSHLPLGGSTLAVLTQGLGHMTLLQSL RLSKSNIDDVGCCHLSKALRAATSLEEL--SLSHNQIGNIGAQDLAAVLP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSANG-IGPAGGAR- ------------------------------------------------------------ LAESLTLCRHLEELMLGCNALGDCTALGLAKGLP--QHLRVLHLPSSHLSPEGVLSLGQA LDGCPHVEEISLAENSLAGGVPHFHQGFPVLRKLDLVSCEIDNQTAKPLAASFVLCLALE EITLSWNLLGDEAAAELARVLPQMGRLKRMD----LEKNQITAYGAWLLAEGLAQGSGIQ VIRLWNNRIPPDMAQHLQNQEPRLDFAFFDNQPQVIPRGT >T_rubripes_ENSTRUP00000014676 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GKV------ -TPLNKIFT---E------------LYITDGLSEDV-NTQHEVMQLETT-SQRNALHHNP IKCGDIFK-P--------LTK--REKYIRVVLMYGVAGIGKTFSVQKFTLDWAAGLENQD -VNLVIPLSFRELNL------IKDGRYSLLELLWVFHSTLQ-----EMAAEML-A-ACKL LFIFDGLDESRLQM-DFNNS----RVVSDVTEESSVDLLLTNLIRGNLLPSALVWITSRP AAGDRIPPRLVD-RVTEVRGFTDSQKEE-YFR---IRFSD-----------------E-- -DLSNRIISHVKTSRSLHIMCLVPIFCWITATVLEHMFS---------TDEREE-LPKTL TDMFSYFLLVQINK--KKQ-KYGGEYEA----SPQELTESDRGHLLKLGQLAFEHLENGN IVFYQEDLEQC--------------GLDAKEVLV-YSGVCTEIFKRE----S-VIFQKSV YCFVHLSIQEFLAAVYMFQCFTSRNTQVLDNFLNT------------------------- -----------------HVPDLNTFLTEAIMKSFESK----------------------- -------NGHLDLFVRFLHGLSLEANQRILGGLLGP-TDNS-S-EVISNAIANLKQMK-- ---------------SVDIPPERSINIFHCLMEMNDQSIHQDIQEFLK-S-QNKSETK-- ------------------------------------------------------------ -----LTEVHCSA----L-------AYMLQMSE--KVLEELNPEKY-NTSMGGRQRLV-- ---------------------------------PAVRNCR-------------------- ------------------------------------------------------------ ---------------------------KAKLSNSRLSDVHCEVVASALRSNPSHLRELE- --MSVN-KLQDSG-VKLLCAGLESLNCRL------------------------------- -ETLE----------LRNCS--LSRLSCASLASALRSNPSHLREL--------------- ----------------------------------------------K--LSENELEDSGV ELLCDYLANPQ------------------------------------------------- ------------------------------------------------------------ CRL--ETL--RLSCCRLSQVSCAAL---TSVLMSNPSHL-ELELSY--NRLQDSGVELLC EFLRAPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CQLESL--GLRGCSLSGDSCTSLASTLK---------- ------------------------------------------------SKTDPSHLREVV ------------------------------------------------------------ ---------------------------------------------LSYNR-LQETDLKML ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_mulatta_ENSMMUP00000001043 ------------------------------------------------------------ -----------------------------------------MDPIDL-------QLGNKN LWSCLVRLLSKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSATWQSF IHCVCMQLEVPLELEVL------LLSTFGCDDGFTSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------EGKSLPESQLHQ GLKRPHQSC---GSSP-RRKQCRKQQLELAKKYLQLLRTSAQQRYGSRIPGSGQP----- -HALHQVYV---P------------PILR--RATASLDTQEGAIMGDLKVED-----GTD VSISDLFNTR-------------VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLDC- -FQALFLFEFRQLNL-------ITRFLTLSQLLFDLYLSPESDPD-AVFQYLE-KNADQV LLIFDGLDEALQPM--------------GPDGPGSVLTLFSRLCRGTLLPGCRVMATSRP GKLPACLPAEA--ATVYMLGFDGPRVEE-YVN---HFFSA-----------------Q-- -PLQEGALAELQTNGRLRSLCAVPALCQVACLCLHHLLP------DHAPGQSVA-LLPTM TQLYMQMVLALSPR-----------------------GHLPTTSLLDLGEVVLRGLETGK VIFYAKDIAPP--------------LIAFGATHS-L--LTSFCVRTG------PGHQQTG YAFTHVSLQEFLAALHLMASPKVDKDTLTQHVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------LDLSDHLPTFLAGLASCTCRPFLSHLAQG-NEDC-VGTKQAAVVQVLKKLA-- ---------------TRKLTGPKVVELCHCVNETQEPELASLTAQSLPYQ-LPFHNFP-- ------------------------------------------------------------ -----LTCTDLAT----L-------TNILEHRE---APIHLDFDGC-PLEPH-------- ------------------------CPEAL----VGCGQIE----------NLSFKSR--- KCGD-----AFAEALSRSLP------------------------------TMGRLQMLGL AGS-KITAR-GISHLVKALPLCP-QLEEVSFRDNQLSDQVVLNIVEVLPHL-PRLRKLD- --LSGN-SVCVSTLLCLARVAVTCPTIRTLQARKADLIFLLSPPTETTAELQRAPDLQES DGQRKGAQSRSLTLRLQKCQ--LQVHDAETLIALLQEGPH-LEEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAASQLHIARKLDLSDNGLSLAGVHCVLRAVSACWTLAELHISLRHKTVVFMFAQE PEEQEGP----QERAAFLDS--LMLQMPSELPLSSRRMRLTHCGLQAKHLEQLCKALGGS CHL--GHLHLDFSGNALGDEGATRL---AQLLPGL-GALQSLNLSE--NGLSLDAVLGLA RCFSTLQWLFHLDISFESQHILLRG-----DKTGRDIWATGSSPDFPAGAEFLGFRRRCI PRSLRLSECPLEPPSLTHLCATLKECPGPLELQLSCEFLSDQSLETLLDCLPRLPQLSLL QLNQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEQEGVCCGRFTGCSLS QEHVESLCRLL-SKCKDLSQVDMDACLRGTGGEKRVRVCPYSHVPAYASQNQLMNLCPHE TTSHFPSTPASGNRHYAFFYMSGFICICLYLSFCDWLISFGIMSSGSFMLQHVSLCQTFL LFFLRWSLALVTQAGVQAPKITFFFETESRSVAHVGVQ----VQEPWADRAGILSLLEVC AQASGSVTEISISKTQQQLCVQLEFPRQEENPEAVALRLAHCDLGTHHSLLVGQLMETCA RLQQLSLSQVNLCEDNDDSSLLLQNLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHH LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLGHLLLNSSALTLLTHGLSHMTRLQSL RLKRNSIGDVGCCHLSEALRAATSLEEL--DLSHNQIGDAGVQHLATILP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSVNS-ISPAGGMQ- ------------------------------------------------------------ LAESLILCRHLEELMLGCNALGDPTALGLARELP--QHLRVLHLPFSHLGPGGALSLTQA LDGSPHLEEISLAENNLAGGVLHFCKELPLLRQIDLVSCKIDNQTIKLLTSSFTRCPALE VILLSWNLLGDEAAAELAQVLPQMGRLKRVD----LEKNQITAFGAWLLAEGLAQGSSIQ VIRLWNNPIPCDMAQRLKSQEPRLDFAFFDNQSQA-PWGT >G_gallus_ENSGALP00000011599 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KNSVKSVERDSVTYSQQEKEEAV IERSQIFQ-M--------PGG--KELETKVIVVLGKAGMGKSVLVQKICQDWSNGEFPQ- -FEFVFWFDCKQISL-------PEKWYSLKDLLLDFFVRPQEGSK-EIFEYIL-QNSTKV LLVFDGLEGLHGHE-NSPHC----SASQPNKDLCRVKELLSGLIQKKILNGCTLLLTART KEKVCQYVSKVD-KTIEIVGFSPWQREL-YIS---KYFEG-----------------L-- -PSCDNALNLIKEHEYLFSHCYSPVMCRFVCFLCETILE---------MGDQG--LPSTL TTLFLKFDVTLA---------------------------QNQENLATLACIAWYLGEKHL SAMKSDLLPSK--------------EVKEFALKNGF--FLPFAFPKH----SDTGEEEYG TMFSDFVIQNFLGALHLILTEGIKNKSLIKYLSFPS------------------------ -------------------------------KKKKPY----------------------- --------NWLHFVPRFLAGLLFLQDDTYFCSLSNK-GVKK-STKKQKMLLKYIKRLQ-- ---------------IDNLCPERLLELLHCIYETQNSYLLQHVALRLKPD-LSFLGIV-- ------------------------------------------------------------ -----LTPPDVHV----L-------SSTLKRSR---KEFSLDLQNS-SIDTHGLKDLVGL KNVVSFRASLSDTIRLWKYLEQTKDYELL---RVSTEKFV----------LDPFKAKTMR DIID-------LSDLVEMQEIIINRVQDDSGCSSYQIP------------AIKNLRKLEF A------------------------------LGPACGLQGFLKLVEILAAF-PSLQHLDL DALSEN-GIGDEG----------------------------------------------- ---------------------------AKSLSEVFPTLTS-LETL--------------- ----------------------------------------------N--LSQNKITDVGA EKLATALPSLS------------------------------------------------- ------------------------------------------------------------ -SL--TTL--SLYNNSICDFGAENL---AKVLPAM-ASLRVLDIQY--NKITDVGAQQLT DSLRKC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PHIKNL--VMWNPTIPYGVLEHLQQ------------- ---------------------------------------------------LDSRISV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_domestica_ENSMODP00000029848 ------------------------------------------------------------ -----------------------------------------MDSLSM-------QEDGES LHHHLVGLLSEDFEWLISKAKFYLPGLDLAPVEKVPDLNQKVDLLLRHLRSHG-SIWRSF IDCVCMEHTMPLYLETM------FLSVWGTSSGKYSRMAK-------------------- ------------------------------------------------------------ ------------------------------------------------KGRNLPFVSLHH CLKRPSTEK---GSSP-CRKWSKQQQLESARSYERLLRVCLQQRYGSAQTRAAMPRQGRP -FSFSQTYV---E------------PVIRRGKVAWLKENPEKPQGDAPEGDD-----GAN LKVQDLFKSH-------------SGTGTKVTVMLGKPGAGKSMLMHRICQKWADGELDQ- -FSKVFYFEFRQLNL-------MKQELTFLQLLFELYLSPEDEPG-AIFHHLQ-ENAHQV LLVFDGLDEFLFPW-PNKGP----KVDLDPTQPVTVSTLFSSLCNGSLLPGCWVVTTSRP GKIPAFLLTTAT-SVFEVWGFDWLQIEK-YVS---NFFHG-----------------L-- -PCQDMALTQLRDNARLQSLCSVPALCCIICICLYHLLL---------QGNTMN-FPTTV TQFYMQMLHTFVSR--KQG----------ACGDKGTWLSKNSQAVLGLGELALMGLKTKR VVFYPSDIPEQ--------------VLAFAATYN-L--LSSFRVKTG------ISQQETC YAFVHLSLQEFFAALYLMVNPTTDETELRRHFF--------------------------- -------------------------LKSKWSLRTEAK----------------------- -------TELLDQFHTFLSGFSSQTCQAFLSQLSQQ-DEAW-VGTKQAAIRQVLQRLA-- ---------------ARSLTGPKMIELCHCVVETQDLELVKQASKHLPFS-LDFHNFP-- ------------------------------------------------------------ -----LTHTDLAA----L-------TSLINHAP---TSVHLVFSGC-SLEPR-------- ------------------------CLDAL----ADCEKIE----------SLSVRSR--- KCRD-----AFAEALSRTLP------------------------------TMGNLKKLEL TGN-NISVW-GIDHLVQAFTDCL-QLEEINLQDNRLNDPACLRVIKSLHNM-HRLQKID- --LSRN-SVSVQTVLALVKKAVSYPQITTLEIRKKRPVIFADGTWDPSSSILQK-EKKNE PQDKMVTQDRKLIFRLQKCG--LAIHHAKEIAEMLKHRPF-LEEV--------------- ----------------------------------------------D--LSGNRLEDEGC QKLAEILPDLQITKQFNISDNGLSKTSVYCLLTAANACKNVMELDISLKNKTAILKFAED QEKAQTQ----SRYFPN-----AFSEELETYGFVFVLYRLRHCGFHSKDLEKLCGELSNC SHL-------DLSNNCLGSKGIEKL---THLLPGL-RSLQLLTLNE--NRTSLEAVFCLA STFSNLEWIYEVDIREQFLVVL-----------GDEFSGLSKSPPFPSVFAYKGFRPWNC CFYFSLRECQMEPPDLKKLLQILKTCHGCLEIKFSHVIMSDESIEELLNHLPQLHSLNLL QFSQTNLSQKSTFLLASAVNLCKQIQKVEVRYVEFACLNFTPGRRKGVSC--GFTGHCIS QVDMKQLYWTL-GQCKDLSHLDLSRNLLGDEGLKYLLEHLPQMNLSGSLNLSHNDISWEG AMRFITALSAWRQVHEVSVSLDPEQRFLIQFTEHPEARKTLRLTRFSFQQEHIAKLATLV GQVPKLTDLILTDNTISLEGLQLLLNLVKMPSAILRISQGSYTERKKMAFLQSYLGTVLG VIWHTVLLSSSISRQELLLQIEEVFSGETENSGATTFRFTQDDLGASQTFVIRWVVEKYI RLQELSWSQVHLC---DTSTQLLKTLLLSLLELKKFRLTDSSMSPVGMCQVASGLSHCHT VEELDLSNNEFSVEGTRVLMGALEGKCQLKNLNLRSLQLDEMALDVLSQRLQRMPLLQRL DLSNSGLSSISCSCLSDSLRNATNLEDL--HLSHNKIEDAGVQCLAAILP---------- ---------------------------------------------------RLPQLRKID ------------------------------------------------------------ ---------------------------------------------LSWNG-ISPEGGRR- ------------------------------------------------------------ LAEALALCHRVEELHLGANAMGDLMAMELAQNLP--RHLKVLYLCFNQIGPEGTLSLGQA LAKCHCIEEISLAGNIFAEGFLPLSKGLLKLRKINLTSCKINDLMAKSLASSLVLCHDLE EILLAWNSLGNEGATELAHVLPQMNQLKKLD----LEGNQIGSLGAQLLAKGLAEGPGIQ VISMWKNPVPEDIAQFLQGQDPRLNFS------------- >G_gorilla_ENSGGOP00000008682 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TP PGGPSSLGNMPSQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGEC------ -VNLSHRYT----------------XLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASP IKIETLFE-P--------EEE--RPEPPRTVVMQGAAGXGKSMLAHKVMLDWADGKLFQG RFDYLFYINCREMNQ-------SATECSMQDLISSCWPEPS-----APLQELI-RVPERL LFIIDGFDELKPSF-HDPQG----PWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQADQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLE----GG----GLLRQ-TSRTT TAVYMLYLLSLMQP--KPG----------------APRLQPPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGEDVSA-F--LNMNIFQKD----I---NCERY YSFIHLSFQEFFAAMYYILDEGERGAG--------------------------------- ---------------------PDQDVTRLLTEYAFSE----------------------- -------RSFLALTSRFLFGLLNEETRSHLEKSLC--WKVS-P-HIKMDLLQWIQSKAQS ---------------DGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQ-V-IVV-SNI-- ------------------------------------------------------------ -----ASKMEHMV----S-------SFCLKHCR---SAQVLHLYGA-TYSADGEDRARCS AGAHTLLVQLRPERTVLLDAYSEHLAAAL----CTXPNLI----------ELSLYRN--- ALGS-----RGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI-ANKNLTRMDL SGN-GVGFP-GMMLLCEGLRHPXCRLQMIXXXXXXXXXXXXXXXXXXXXXX-XXXXXXX- --XXXX-XXXXXX-XXXXXXXXXXXXXXX------------------------------- -XXXX----------XXXXC--LTAAACDELASTLSVNQS-LREL--------------- ----------------------------------------------D--LSLNELGDLGV LLLCEGLRHPT------------------------------------------------- ------------------------------------------------------------ CKL--QTL--RXXXXXXXXXXXXXX---XXXXXXX-XXXXXXXXXX--XXXXXXXXXXXX XXXXXXX----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------XXXXXX--XLDSCGLTAKACKNLYFTLG---------- ---------------------------------------------------INQTLTNLY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGDTGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KRLSHPGCK---LRVLW----LFGMDLNRMTH-SRLAVLRVTKPYL DIGC------------------------------------ >C_familiaris_ENSCAFP00000013161 ------------------------------------------------------------ -----------------------------------------MDHVSF-------QLGTTN LWSWLVRLLSKDPEWLNAKVKFFLPKMDLSSGDEAQDTTQRVMLQLRRLHTQGRATWQAF IHCVCMELDVPLDLEVP------LLSTWGHGDGFPSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------GEESQPASQLHH GLKRPHQSC---GSSP-RLKQCKNHQLELARRYLKLLRTSAQQRY-SRIPGPGQP----- -LAFHQAYI---P------------PILQWSRTTAPFSAQDGAVVGDPKAED-----DTD VSIRDLFSTR-------------ADKGPRVTVLLGKAGMGKTTLAHRLCQRWAAGQLDR- -FQALFLFEFRQLNL-------ITSSVTLPQLLFDLYLSPEAGPD-SVFQYLE-EHAGGV LLIFDGLDQALHSHSS--------TEPEGPEAPSPALALFSGLCRGTILPGCWVLATSRP GKLPDCLPTEA--ATVHMWGFDRPRVEE-YVG---RFFSD-----------------Q-- -EWQEAALAELRENRHLQSMCAVPALCQVTCLCLHHLLP------GNSPGQSAA-LLPTV TQNYVQMVSTLSPR-----------------------GYLPPESLLGLSEMALRGLETGK VIFSVGDISPP--------------MVAFGAALG-L--LTSFCICTG------PGHQGIG YAFTHLSLQEFFAALYLMASPKVDKNVLARHVT--------------------------- -------------------------LNSRWVLRTKAR----------------------- -------LGLLDHLPTFLAGLASCACRPFLSHVAQQ-DEMW-VSDKQAAVMLALRKLA-- ---------------IRRLTGPKVVALCHCVGETQEPELASLMAQSLPSH-LSFHNFP-- ------------------------------------------------------------ -----LTYTDLSA----L-------TNILRHRN---ASIHLDFEGC-PLEPH-------- ------------------------CPEAL----AGCKQIE----------NLSFKSR--- KCGD-----AFAEALSKSLP------------------------------TMESLKKLGL AGC-KITAR-GISHLMQALRLCP-QLEEISFQDNQLKDRAVLNIVEVLPSL-PRLQKLD- --LSRS-NVSVSTLLCLTKVAVTCPTVKMLQVRETDLIFLLSPPTETAAELGAAPDLQGN AIQRKEAQSRSLALRLLQCQ--LGIHDVQELIAQLREGPR-LEEV--------------- ----------------------------------------------N--LSGNQLDDEGC RLMAEAASQLHITRNLDLSNNGLSVDRVHCMLSAVNTCQNLAELHISLLHKTVVFTFAPE QEEQEGI----WKRTALRDS--LTHQVPFELPLRSTRIRLTHCGLQAKHLEQLCRALGGS CHH--SHLELSLSGNALGDEGVAQL---AQLLPGL-GALQSLNLSE--NGLSLDTVFILI QCFSTLQWLLHLDIGFESQHVVLRG-----DRRGRDRLAGGCPPEFLAGVPFLAFDQCCV PESFCLRQCQLEPLNLTRLCETLEKCPGPLEVELSFEVLSDQSLETLLQHLPRLPQLSLL QLSQTRLSPKSLLLLADLFSLCPRVQKVDIRSLYHMTLHFRSGEEHEGECCGRFTGCGLS QEHVEPLCWLL-SKCEDLNQLDLSANMLGDDGLRCLLECLPQLPISGSLDLSHNSISLES ALGLVKTLPSCPHIREASVNLGSEQSFWIYFSRKEEAGKTLRLSQCNLMPEHVPRLATHL NQALKLTALTLTQCGLGLEQLIVLLSLLRCPVDLFTLR----VEEPWVGKAGVLALLRVC TQTSGNITEISISETQQQLCLQLEFPPQ-ENPEAVTLRLAHCDLETHHSLLAGQLMETCA RLQQLSLSQVNLC---DSSSLLLKNLLVSLSELKTFRLTSSCMSSKGLAHLTFGLRNCHH LEELDLSNNQFGEEDTEVLMTVLEGKCWLKKLDLSHLPLGSSTLAMFTQGLSHMTLLQSL RLSRNGICDVGCHQLSEALRAAMSLKEL--GLSHNQIRDTGAQHLAAVLP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSGNG-IGPAGGTR- ------------------------------------------------------------ LAESLTLCRHLEELMLGYNVLGDTTALGLAQGLP--CCLRVLHLPSSRLGPKGALSLSQA LDGCPHVEEISLAENSLARGVLHFCQGLPLLRQIDLVSCEIDNHTAKPLAASLVLCPALE EILLSWNLLGDEAAAELARVLPQMGRLKRMD----LEKNRITACGAWLLAEGLAQGSGIQ VIRLWNNPISPTMVQHLQSQEPRLDFAFFD---------- >C_familiaris_ENSCAFP00000003989 ------------------------------------------------------------ ----------------------------------------------------MPRAPPSS GLCRLSAYLEELEAVELKKFKLFLGT--------EAEA--GRIPWGRLEAAGPLDTAQLL VAHCGPHAAWPLALGLF------QRINRRDLWEKGRREEP-------------------- ------------------------------------------------------------ -------------------------------------------------------VRDTP SGDPSSPGS---QSACSLEVFPGALRRDPRETYRDYVRRKFRLMEDRNARLGEC------ -VNLSHRYT----------------RLLLVKEHSNPMWAQQKLLDTGWGQARTVGHQASF IQMETLFE-P--------DEE--RPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGRLFQD RFDYLFYINCRKMNQ-------STAEQSAQDLISSCWPEPS-----VPLQELV-RVPERL LFIIDGFHELKPSF-HDPQG----PWCLCWEEKRPTELLLSSLIRKKLLPELSVLITIRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQAGQVFNFIRDNEPLFTLCFVPMVCWVVCTCLKQQLE----DG----GLLRQ-TSRTT TAVYMLYLLSLMQP--KPG----------------SPILQSPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGADVSS-F--LNMNIFQKD----I---NCEKF YSFIHLSFQEFFAAMYYILDPGESRSS--------------------------------- ---------------------PEHNVTRLLAEYEFSE----------------------- -------RSFLALTVRFLFGLLNEETRSYLEKSLC--WKVS-P-HVKVELLEWIQRKAQS ---------------EGSTLQQGSLELFSCLYEIQEEDFIQQALSPFQ-V-VVV-NNI-- ------------------------------------------------------------ -----ATKMEHMI----S-------SFCVKNCR---SALVLHLHGA-AYSPDEDDGGRWA SGPQMLPTQI-PEKNVLPDAYSKQLAAAL----STNPNLT----------ELVLYRS--- ALGS-----RGVRLLCQGLRHPSCKLQNLSLKRCCVASSACQDLAAALM-ANQNLRRMDL SSN-RLGLP-GLRALCKGLRHPRCKLQVIQLRKCQLEAEACQEIASVLSTS-RHLEELD- --LTGN-ALEDLG-LKLLCQGLRHPVCRL------------------------------- -QILW----------LKICH--LTAAACEDLASTLGVNQS-LIEL--------------- ----------------------------------------------D--LSLNDLGDPGV LLLCEGLRHPQ------------------------------------------------- ------------------------------------------------------------ CRL--QAL--RLGICRLSSAACKGL---CTVLQVN-PCLRDLDLSF--NDLGDAGVWPLC EGLRHPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQKL--WLDSCGLTAKACEDLSSALG---------- ---------------------------------------------------VSQTLRELY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGNAGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KGLSHPGCK---LQVLW----LFGMELNKMTH-RRLAALRVVKPQL DIGC------------------------------------ >T_rubripes_ENSTRUP00000004992 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LKGKFRWVSEGLTKAGRS------ -TLLNQIYT---E------------LLITEGGSGGV-NNEHEVRYIEQA-SRKAKTQEIT VGREDIFK-P--------LPG--RDKSIRTVMTTGVAGIGKTVLTQKFTLDWAENKTNQE -TQFIFPFTFRELNY------LKGKTYSLVGLVHDFFPETK-----QAGLCRF-D-HFRV VFIFDGLDECRLPL-DFRSN----KTVTDPTESASVDVLLTNLIKGTLLPSARLWITTRP AAAALVPADCID-RATEVRGFTDLQKEE-YFR---KRLGD-----------------R-- -QHASTIASHVKMSRSLHIMCHIPVFCWITATVLEDVLN---------SAEGAQ-LPKTL TEIYIHFLVIQLKL--KNV-KYDGRGET-----DSHWCPQSRDLVECLGKLAFEQLQKGN VIFYESNLTEC--------------GIDVTAATV-YSGMFTQIFKEE----K-SLYQTKV FCFIRLSVQEFLAALYVHLRQK-------------------------------------- -------------------------------IKFKWP----------------------- -------KQDLNSLHRSV------GQSDAAAWSADK-TEGA-S-RAILKTRTYLKKKI-- ---------------DPNLSPERNINLLHCLNELKDSSLLEEEALTL------------- ------------------------------------------------------------ -----LTCLLLSG----Q-------LWSLYYCHQRKIWTHLTLRNT-LIQRKELRCCFQC SKPPEKLCTYPTDMHY--------LDSMGGKNQCIFKCII----------LFRLTGC--- NLSK-----DNCKLLGSVLSS-----------------------------ESSALRELDL SNN-NLEQP-KMKLLAAGLESPCCNLQSLRLSSCVITEDSCACLALALQTNPSHLKELD- --LSYN-PLGDGG-VMVLSAALKDPHCML------------------------------- -HKLR----------LSGCN--LSEGSCRDLALVLSTETSSIKDL--------------- ----------------------------------------------D--LSDNNIQDSGL MLLSDGLNSPH------------------------------------------------- ------------------------------------------------------------ CQV--EVV--RLSGCDLSPKSCEVL---ASALNFRALSLRELELNN--NNLGDSGVELLS AALKAPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CSLQTL--RLSGCLVTDVGCASLASALN---------- ----------------------------------------------------GSCLRELD ------------------------------------------------------------ ---------------------------------------------LSYNH-PG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >H_sapiens_ENSP00000375704 ------------------------------------------------------------ -------------------------------------------------------MKMAS TRCKLARYLEDLEDVDLKKFKMHLEDY-------PPQKGCIPLPRGQTEKADHVDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLYEKAKRDEP-------------------- ------------------------------------------------------------ ------------------------------------------KWGSDNARVSNPTVICQE DSIEEEWMG---LLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGES------ -VSLNKRYT----------------RLRLIKEHRSQQEREQELLAIGKT--KTCESPVSP IKMELLFD-P--------DDE--HSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQD RFDYLFYIHCREVSL--------VTQRSLGDLIMSCCPDPN-----PPIHKIV-RKPSRI LFLMDGFDELQGAF-DEHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQME----SG----KSLAQ-TSKTT TAVYVFFLSSLLQP--RGG----------------SQEHGLCAHLWGLCSLAADGIWNQK ILFEESDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEEKEGRT--------------------------------- ------------NVPGSRLKLPSRDVTVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWIEVKAKA ---------------KKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHMV----S-------SFCIENCH---RVESLSLGFL-HNMPKEEEEEEKE G----------------------------------------------------------- ---------RHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLS-TSQSLTELDL SDN-SLGDP-GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSN-QKLVELD- --LSDN-ALGDFG-IRLLCVGLKHLLCNL------------------------------- -KKLW----------LVSCC--LTSACCQDLASVLSTSHS-LTRL--------------- ----------------------------------------------Y--VGENALGDSGV AILCEKAKNPQ------------------------------------------------- ------------------------------------------------------------ CNL--QKL--GLVNSGLTSVCCSAL---SSVLSTN-QNLTHLYLRG--NTLGDKGIKLLC EGLLHPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQVL--ELDNCNLTSHCCWDLSTLLT---------- ---------------------------------------------------SSQSLRKLS ------------------------------------------------------------ ---------------------------------------------LGNND-LGDLGVMM- ----FC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQSCL---LQNLG----LSEMYFNYETK-SALETLQEEKPEL TVVFEPSW-------------------------------- >E_caballus_ENSECAP00000015250 ------------------------------------------------------------ ----------------------------------------------------MPQIPVRD GLCRLSAYLEELEAVELKKFKLYLGT--------ATEPGEAKIPRGRMEQAGPLEMAQLL VAHCGMQEAWLLALSIF------ERINRKDLWERGRREDL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRDTP PGGLSSLGS---QSACSLEVFPGTPRKDPRESYRNHVRRKFRLMEDRNARLGEC------ -VNLSQRYT----------------RLLLVKEHSNPTWAQQKLLDTGRGHTRTVGQQASL IQMETLFE-P--------DEE--RPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGKLFQD RFDYVFYIHCREMNQ-------NASERSAQDLISSCWPEPG-----APLQELL-RAPERL LFILDGFDELKPSF-HDPQG----PWCLCWEEKRPTELLLSSLIRKKLLPELSLLITTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQAGQVFHFVRDNEPLFTLCFVPMVCWVICTCLKQQLE----GG----RLLRQ-TSRTT TAVYTLYLLSLMQP--KPG----------------TPTLQIPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGVDVSS-F--LNMNIFQKD----I---NCERF YSFIHLSFQEFFAAMHYILEDGESGSG--------------------------------- ---------------------PDQNVARLLAECGFSE----------------------- -------RSFLALTVRFLFGLLNEQTRSYLEKSLC--WKVS-P-RVKAELLEWIESKAQS ---------------EGSMLQQGCLELFSCLYEIQEEEFIQQALSHFQ-V-VVV-SNI-- ------------------------------------------------------------ -----ATRMEHMV----S-------CFCVKNCR---NVVVLHLCGA-AYSADEEDGLRGA EGPQAPLAQP-PERNILPDAYSEQLASAL----STNPNLI----------ELVLYRN--- ALGS-----RGVKLLCQGLRHPNCKLQNLRLKRCQLSGPACWDLAAALI-ANKNLIRMDL SGN-GLGLP-GIRLLCEGLRHPRCRLQMIQLRKCQLEAGACREIASVLSTN-RHLVELD- --LTGN-ALEDLG-GRLLCEGLSNPVCRL------------------------------- -QILW----------LKICR--LTAAACEDLASTLSVNQS-LVEL--------------- ----------------------------------------------D--LSLNDLGDAGV LLLCEGLRHPQ------------------------------------------------- ------------------------------------------------------------ CKL--QTL--RLGICQLSSAACEGL---SAVLQVN-PHLRELDLSF--NDLGDRGVWLLC EGLRHPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQKL--WLDSCGLTAKACEALSCSLG---------- ---------------------------------------------------VNRTLRELY ------------------------------------------------------------ ---------------------------------------------LTHNA-LGDTGVRL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KRLSHAGCP---LRVLW----LFGMALNPMTH-RRLAALRVAKPSL DLGC------------------------------------ >D_rerio_ENSDARP00000035227 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------EEEKE-EVFAFIL-THPDKV CFILDGYDEFRAKLTDPREL----ESTVDLSTPMPMADLLSGLCSRKILPDCTVLVTCRP RDVTDMFGSPGL-ITCELQGFDRLGVKE-YAE---QYFHE-----------------K-- GDLKTNAVNLLMDNRHLLSMSHVPGLCHICCICVDHLFS----SGEVLNHQ----LPTSL TQIYIQILLAFLSRFNEDG------------VSKTSLLMRYRTKIVEMSQLALKGLEGST IVFMETEVSKE---------------LQDFGVRSGI--LSRVKLTHE------DGSSGYG FTFMHLTMQEFLAALHLMTSQTITDGQLKKKLN--------------------------- -------------------------LKTRWTTKTDPK----------------------- -------SVFTDSVHLYVCGLAAEACTSCLVQLKGAESETTWVKKRQAAVRNVLLGLAG- ---------------GASHTGPKIVELCRCAHETQDAKLAKAIGSRPQ---IELRNIR-- ------------------------------------------------------------ -----LNAVDMDS----L-------AFVTAAAD---QTVCLDFGGC-SIDLD-------- ------------------------CLEIL----PSFKNVD----------HLIFRSR--- KYDD-----KFAETLCGILS------------------------------KLQALQQLDF ISG-GLTDV-GAAKLAKALEDCP-NITHLNVSDNSLKDEGIREIAETVSRL-HNISSIL- --MGKN-NISTDGILTLIERMAACTSVQEVHVDIKHCLFYLALLCFMGNKEINLSFSKRS -DTIRVGNTPDLQIVLFIFT--FPVCSSFVVIKLFQKDPN-LTSV--------------- ----------------------------------------------Y--ITDNVSQYIHL TRQTNKQSNKQ-HTPPETLPTIRSLNKQQHVIKSTNNLICKRENNLSLIRRSDLIDLKKE GRLFQSEGALYRKDLQPLSVEILGTKNNSVAHDEANMMILKQCNLTVSHVASLCNKLRGF AIL--TLL--DLSNNSLGNKGLKKI---LDLLPKL-GGIQEINVSE--NGVDMEGVVMLA SALCKQN-------VYHGNVAITSVLHECRHNSGELTQNETGMQLHKKLRAGASIEGLSQ SPDLNLTHSDIQPAYMTKLCKQLVKCKNLLDIDFSNLKLTDDSVENLMLILPVMLSLHVL NLSHVDLSTNGALILVRSLADCQRVTSVELRHQAEAFIKFVPE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KAEVAICNRLTEYNLSKTNVVKLSKILE---------- ---------------------------------------------------SCPHLSELD ------------------------------------------------------------ ---------------------------------------------LSHNV-LRDEGVKC- ------------------------------------------------------------ --------------------------------------------------------FVDH LPKLKISSSVSLIGNRMTQIGALHLVNSMNTCEKVVAVEVSLGVEDQSLIQFVQEHANGK TLRLRECSFELAHLKMLVKILTKCPRLLSLE----LSSNSLNSQGLFSLLDSLAELSTIQ TLTIVPKLGKNS---------------------------- >O_latipes_ENSORLP00000001319 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VLTSGIAGIGKTFLVQKFTLDWAEGLENQD -VISVVPLSLRELNL------VRDEQYSLHSLIQLFHPAFQ-----KIPAEQL-D-VNKL LFIFDGLDESRLSL-DFHNS----QVVSDVTQKSSVSVLLTNLIQGRLLPSALVWITSRP AAAHQIPEKLVD-RLTEVIGFDDSQKEE-YFR---KRFSD-----------------E-- -EQFSRIISHIQSSRSLHVMCRVPIFCWITATVLEHMLT---------TEDRGE-VPTTL TDMYSQFLMVQTKR--KK--KYQQGCET----CPQEVTEADREVLLKLGKLAFKHLEKGN IMFYQEDLQQC--------------GLDVTEALL-HSGVCTEIFRRE----C-MIFQRPV YSFVHLSVQEFLAAVYMFYCFTIKNTEVLENFLVS-----------------QKQSNRPS TLQSFFNMFWPSEKDVPHFPTLDEFLSKVMEKSLQSD----------------------- -------AGQLDLFVRFLHGLSVESNQRLLGSLLCH-TENS-A-ESLQKVIDNLKMMK-- ---------------SYSSSPDRSINIFHCLVEVKDLSVHQEIQEFLQ-T-ENRSDK--- ------------------------------------------------------------ -----VSAEPLSS----LKFTRAICAKSLKSRP--SHLRELDLSHN-TLQDSGMKILSDG LES------------------------------PNCRLET-----------LRLRSC--- TMSE-----AGCTALVSALKS-------------------------------SHLMELDL SDN-RLCDS-AVRHLCGFLQSSHCTLKTLRLSSCRLSESSCAALLSALKTNPSHLTSLD- --LSDNVNLLDSG-AERLCGLLKGPQSRL------------------------------- -RTLR----------LRSCS--LSVRSCASLASALKTNPLHLTQL--------------- ----------------------------------------------D--LSDNKLQDSGV EQLCDFLMVPD------------------------------------------------- ------------------------------------------------------------ CRL--ETL--RLEDCSLSEKSCAVL---ASALISIPSHLTHLDLSF--NKLRDSAMKHLC GFLRSPH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CSLHTL--RLEDCRLSATSCSTLFSTLQ---------- --------------------------------------------------SSSSRLTELD ------------------------------------------------------------ ---------------------------------------------LNRND-LKASDVQK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LLDLVESPDCKLETL------------------------------ ---------------------------------------- >M_domestica_ENSMODP00000006449 ------------------------------------------------------------ -----------------------------------SGQCTAMESGPLSEGSYLGLLQSEI DPLQLFHFYDQ-PLPGEEEIEFTSDPDTDTINCDQVDRLWNAIE-NEGAGEAYDRIAALA EYMFSDPHPE--TEGIF-GNIDPDEVVNENIDALAEVPQKSQKTKRQPIPEEIIVA---- KETSPAIPLVTNNLVTASSNDNLVLKDSLSPLPGQVAKPSLPSMKEAFLVPMSSASPVFT CLNFNGGPIQLIPTFPTLPQGVFQFT-VENGVSNIFFYPGKHITNVNH-----SFYPHHL PVSPDRPGS---TSPLVPSAADMPNMPE---ASALTLQSRKTGNIQMI---ELPTPLWAF AESVEGFCRALQKAYGDVPKGQSSYYIDIELTRTQVEK-NSKYQEKDLAIQDWTERQKAR VGWREVFA-R--------PSG--QKGETQVIAVLGKAGLGKSAWTREICRNWAQGQLPQ- -YEFVFHYKCHGLNL-------PGNDYCLKDLFFRLCHHSLEESE-EVFKYIL-KHPNHI LVILDSFEELEGQD-GLLHY----LASSSPREPQPIKGLLAGLFQRKLLRGCTLLITTRP KGRFIQYLAKVD-SLLEVQGFSPEQVEA-YFE---KYFQS-----------------S-- PSDRDEALRLLRTQPYLLSHCYSPAVCLSLCQLCEKVLA---------AGGPAQ-LPSTL TGLFVSLFCSALRAKKKGT-----------------SETWPRRCLAGLAELAWERGQRHC RVLREDQFPSK--------------EVKEFTVSGDF--MW-----------PLPTARDPE MVFSTFLLQNFLGALRLALSGEVRHKELPRYIALTP------------------------ -------------------------------RKKKPY----------------------- -------DNWLDRVPHFLTGLLFQPLSSCLGLLGGD-EQVELVCKRKKVLLSYLTRLQ-- ---------------PGTLGPGKLLELLHCAHEAADRQLWEHVTAGLPSY-LSFWGVR-- ------------------------------------------------------------ -----LAPPDVHV----L-------GEALKAAG---KDFSLDLRST-SIDLHGLRILVQL GCVTCFRASLSDTVWLWESLQQSGEHELL---QSSTKKFT----------IDPFKVKSMK DVED-------LCSLVHIQS-----SGNVPTEACDPLP------------AIRDLKKLEF A------------------------------LGPGLGPQGFPKLVKILAAF-SSLQHLDL DTLSEN-KIGDEG----------------------------------------------- ---------------------------VTQLSAIFPELKV-LETL--------------- ----------------------------------------------N--LSQNCITDVGA TELAKALPSLA------------------------------------------------- ------------------------------------------------------------ TSL--VTL--SLYNNCICDTGAKNI---ASVLPSM-VSLRVLDVQY--NKFTDAGAQQLT ASLKKC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PHIETL--AMWNSTIPYGVQEHLQH------------- ---------------------------------------------------LDSRISLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >D_rerio_ENSDARP00000091430 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MQKSKSPESSVASVT SDQSTDPPQNYRGHTEL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TFSHDHLHAEVHKTFRSNLLTKFQCVSEGTATDKSP------ -TLLNEIYT---E------------LYITEGDSGEI-NNEHEVRQIETQ-SRRSTTEDTP IQCRDIFT-A--------LPG--QHKAIRTVLTKGVAGIGKTVSVQKFILDWAEEKENQD -VQLIFPLPFREINL------MKDRTLSLADLLHVFFPETK-----EMEISRD---GYKV LFIFDGLDECRLSL-DFNSG----VKLCDISESASVEDLLMNLIAGNLLPSALIWITSRP AAADLIPSAFVH-RLTEVRGFTDPQKEE-YFR---KRIRD-----------------Q-- -RLADEIIQHLKSCRSLFIMCHIPVFCWISATVLEEMMR---------GSRKGE-IPKTL TEMYTHFLIIQTCI--RHE-KHYEKK------------LKDEEMILKLGKLAFRQLMKGN LIFYEEDLREC--------------GIDESEASV-YSGLCTQIFREE----L-GLFQGKV FCFVHLSIQEHLAALYVLLSFLLYERDELSENRRS------------------------- -----------KYAHWFKRQTISDLHQRAVDKALQSR----------------------- -------NGHLDLFLRFLLGLSLKSNQRLLNNHLTQ-VGNI-S-YSQEKTVEYIKTQI-- ---------------KMNPSPEKSINLFLCLNELGDHSLVNEVQEYVR-S-GDLSGSR-- ------------------------------------------------------------ -----FSSSQWSA----V-------VFILLTLE---QLDEFNLRRY-VIGYGHQTQTQKF QTPDKV------------------LQKLL----PVVEASR----------SAVLFDC--- GISD-----KGCAALASALRS-----------------------------NSSNLRELDL SYN-IVGDS-GVKLLSAGLKDPHCKLEKLRLRCCGVSDEGCADLASVLRSNSSNLRELE- --LSKNINVGDSG-VKLLSAGLKDPHCKL------------------------------- -EKLR----------LGYCG--VSDEGCAALASVLRSNSSNLREL--------------- ----------------------------------------------D--LSDNKIVDSGV KRLSAGLKDPQ------------------------------------------------- ------------------------------------------------------------ CKL--ETL--RLINCDVSGKGCAAL---ASALRSNSSNLRELNLSE--NKVGDSGVKRLS AGLKDPH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLEKL--TLNYCGVSDASCADLASALR---------- --------------------------------------------------SNSSNLRELN ------------------------------------------------------------ ---------------------------------------------LKWNR-VEGIGVKW- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LSDLRDDPHYKLETLHISWGFIC---------------------- ---------------------------------------- >P_troglodytes_ENSPTRP00000003728 ------------------------------------------------------------ -------------------------------------------------------MKMAS TRCKLARYLEDLEDVDLKKFKMHLEDY-------PPQKGCIPLPRGQTEKADHVDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLYEKAKRDEP-------------------- ------------------------------------------------------------ ------------------------------------------KWGSDNACVSNPTVICQE DSIEEEWMG---LLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGES------ -VSLNKRYT----------------RLRLIKEHRSQQEREQELLAIGKT--KACESPVSP IKMEMLFD-P--------DDE--HSEPVHTVVFQGAAGIGKTILARKIMLDWALGTLYQD RFDYLFYIHCREVSL--------VTQRSLGDLIMSCCPDPN-----PPIHKIV-RKPSRI LFLMDGFDELQGAF-DEHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -AQARAAFSLIQQNEVLFTMCFIPLVCWIVCTGLKQQME----SG----KSLAQ-TSKTT TAVYVFFLSSLLQP--RGG----------------SQEHRLCAHLWGLCSLAADGIWNQK ILFEESDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEEKEGRT--------------------------------- ------------NVPGSRLKLPSRDVTVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWIEVKAKA ---------------KKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCH---RVESLSLGFL-HNMPKEEEEEEKE G----------------------------------------------------------- ---------RHPDMVQCVLPGSSHAACSHGLVNSHLTSSFCRGLFSVLS-TSQSLTELDL SDN-SLGDP-GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSN-QKLVELD- --LSDN-ALSDFG-IRLLCVGLKHLLCNL------------------------------- -KKLW----------LVSCC--LTSACCQDLASVLSTSHS-LTRL--------------- ----------------------------------------------Y--VGENTLGDSGV AILCEKAKNPQ------------------------------------------------- ------------------------------------------------------------ CNL--QKL--GLVNSGLTSVCCSAL---SSVLSTN-PNLTHLYLRG--NTLGDKGIKLLC EGLLHPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQVL--ELDNCNLTSHCCGDLSTLLT---------- ---------------------------------------------------SSQSLRKLS ------------------------------------------------------------ ---------------------------------------------LGNND-LGDLGVMM- ----FC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQSCL---LQNLG----LSEMYFNYETK-SALETLQEEKPEL TVVFEPSW-------------------------------- >M_musculus_ENSMUSP00000078440 ------------------------------------------------------------ ---------------------------------------------------------MTS VRCKLAQYLEDLEDVDLKKFKMHLEDY-------PPEKGCIPVPRGQMEKADHLDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLWEKAKKDQP-------------------- ------------------------------------------------------------ ------------------------------------------EW--NDTCTSHSSMVCQE DSLEEEWMG---LLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGES------ -VDLNSRYT----------------QLQLVKEHPSKQEREHELLTIGRT--KMRDSPMSS LKLELLFE-P--------EDG--HSEPVHTVVFQGAAGIGKTILARKIMLDWALGKLFKD KFDYLFFIHCREVSL--------RTPRSLADLIVSCWPDPN-----PPVCKIL-RKPSRI LFLMDGFDELQGAF-DEHIG----EVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSN-----------------E-- -LQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQQME----TG----KSLAQ-TSKTT TAVYVFFLSSLLQS--RGG----------------IEEHLFSDYLQGLCSLAADGIWNQK ILFEECDLRKH--------------GLQKTDVSA-F--LRMNVFQKE----V---DCERF YSFSHMTFQEFFAAMYYLLEEEAEGET--------------------------------- ----------VRKGPGGCSDLLNRDVKVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QVRLELLKWIEVKAKA ---------------KKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIKNCH---RVKTLSLGFF-HNSPKEEEEERRG G----------------------------------------------------------- ---------RPLDQVQCVFP-DTHVACSSRLVNCCLTSSFCRGLFSSLS-TNRSLTELDL SDN-TLGDP-GMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSS-QKLVELD- --LSDN-ALGDFG-IRLLCVGLKHLLCNL------------------------------- -QKLW----------LVSCC--LTSACCQDLALVLSSNHS-LTRL--------------- ----------------------------------------------Y--IGENALGDSGV QVLCEKMKDPQ------------------------------------------------- ------------------------------------------------------------ CNL--QKL--GLVNSGLTSICCSAL---TSVLKTN-QNFTHLYLRS--NALGDTGLRLLC EGLLHPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQML--ELDNCSLTSHSCWNLSTILT---------- ---------------------------------------------------HNHSLRKLN ------------------------------------------------------------ ---------------------------------------------LGNND-LGDLCVVT- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQGCL---LQSLQ----LGEMYLNRETK-RALEALQEEKPEL TIVFEISW-------------------------------- >P_pygmaeus_ENSPPYP00000008337 ------------------------------------------------------------ -----------------------------------------MDPVGL-------QLGNKN LWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSF IHCVCMQLEVPLDLEVL------LLSTFGCDDGFTSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------EGKRQPESQLHH GLKRPHQSC---GSSP-RRKQCKKQQLELAKKYLQLLRTSAQQRYRSRIPGSGQP----- -HAFHQVYV---P------------PILR--RATASLDTPEGAIMGDLKVED-----GTD VSISDLFNTR-------------VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLDC- -FQALFLFEFRQLNL-------ITRFLTPSELLFDLYLSPESDHD-AVFQYLE-KNADQV LLIFDGLDEALQPM--------------GPDGPGPVLTLFSDLCHGTLLPGCRVMATSRP GKLPACLPAEA--AMVHMLGFDGPRVEE-YVN---HFFSA-----------------Q-- -PSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLP------DHAPGQSVA-LLPTR TQLYMQMVLALSPP-----------------------GHLPTTSLLDLGEVALRGLETGK VIFYAKDITPP--------------LIAFGATHS-L--LTSFCIRTG------PGHQQTG YAFTHLSLQEFLAALHLMASPKVNKDTLTQYVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------LCLSDHLPTFLAGLASCTCRPFLSHLAQD-NEDC-VGAKQAAVVQVLKKLA-- ---------------TRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQ-LPFHNFP-- ------------------------------------------------------------ -----LTCTDLAT----L-------TNILEHRE---APIHLDFDGC-PLEPH-------- ------------------------CPEAL----VGCGQIE----------NLSFKSR--- KCGD-----AFAEALSKSLP------------------------------TMGRLQMLGL AGS-KITAR-GISHLVKALPLCP-QLEEVSFRDNQLSDQVVLNIVEVLPHL-PRLRKLD- --LSSN-SICVSTLLCLARVAVTCPTVRTLQAREADLIFLLSPPTEKTAELQRAPDLQES DGQRKGAQSRSLTLRLQKCQ--LQVHDVEALIALLQEGPH-LEEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVVFMFAQE PEEQKGP----QERTAFLDS--LMLQMPSKLPLSSRRMRLTHCGLQAKHLEQLCKALGGS CHL--GHLHLDFSGNALGDEGAAQL---AQLLPGL-GALQSLNLSE--NGLSLDAVLGLA QCFSTLQWLFHLDISFESQHILLRG-----DKTGRDIWATGSLPDFPAAAEFLGFRQRCI PRSL-----------------------------LSCEFLSDQSLETLLDCLPQLPQLSLL QLSQTGLSLKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLS QEHVESLCWLL-SKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGSLDLSHNSISQES ALYLVETLPSCPRVREASVNLGSEQSFRIHFSGEDQAG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KTLSLSHLLLNSSTLAFLTHGLSHMTRLQSL RLNRNSIGDVGCCHLSEALRAATSLEEL--DLSHNQIGDAGVQHLATILP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSVNS-ISSAGGVQ- ------------------------------------------------------------ LAESLVLCRHLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQA LDGSPHLEEISLAENNLAGGVLRFCKELPLLRQIDMVSCKIDNQTAKLLTSSFTRCPALE VILLSWNLLGDEAAAELAQVLPQMGRLKRVD----LEKNQITALGACLLAEGLAQGSSIQ VIRLWNNPIPCDMAQRLKSQEPRLDFAFFDNQPQA-PWGT >G_gallus_ENSGALP00000001906 ------------------------------------------------------------ ------------------------------------------------NDDFNLEGAVAS IRPQLVEFLSHRLDWLLSASQHFLPTAVLSGLAGVTDHREKVSVLLDLLEKAGHATWKQF AQCLCMECDLPLEMEIL------LMSSAGEGNLTQKQEAQ-------------------- ------------------------------------------------------------ -------------------------------------------------TDASDQSSVPR GLTRRRR-----SSSPISDKGAKQKRLDSAEKYQRLLVDSICKRYGSRRAAGAAAQEPTQ PLAFSQAFV---N------------LVLRQSKASRLKERTDKPREDVPSAPEPEECVDTA VRVSDLFGSVV------------RSGTTKVIFLFGKPGTGKTMLMHRICQKWAEGVLHQ- -FLFTFLFEFRQLNL-------LKRKLTLKELLFDLFLQPEDSPD-AVFQHLL-ENAQRT LIIFDGLDEFVGSL--------------NRSSSMSISELFAELCHGNLLPGCTVLVTSRP KRVPDFLINTVD-LLAEVWGFDHEKVEE-YVS---HYFRH-----------------H-- -SFKEQAIAHLKNNTKLLSMCQIPALCYVVCICLEYLLL----KH----QTSVE-LPQTM TQFYIKMLLIFINK--QQG---------EHAGDEEAQLNSNKKAILGLCDLALKGLEAKK LVFYVGDIPEH--------------VKEFASLHG-L--LTVFEVKTN------SAHPETG YAFVHLSLQEFFAALCLMISKSVDKSHLKRKLS--------------------------- -------------------------LKSKWTLRNEAK----------------------- -------TGFMESFHIFLSGLSSKECRTFIMLLAEQ-SEAW-VQDKQDAILQSLKKLA-- ---------------ATQLTGPKVIELCHCTFETQGLEVAQHIGSLLNFK-YEFKNFR-- ------------------------------------------------------------ -----LTPLDMSA----L-------VFVINSGQ---DVTHLDFAGC-PLDTD-------- ------------------------CLEML----ASCRNVE----------HLSFRSR--- RFGD-----DFAAALSKGLG------------------------------EMGSLKKLEV TGG-SITAA-GLTDMVQALSHCL-QLEEINLQDNRIQNPDVKTVMELFSRM-EKLKKID- --LSKN-SLSLNAVLLLAKEFIACQNAAELHVRKDTVIISFSGP---SGKVPRSLDLKRE QNKECVTPTRHLRLCLQARC--LSSQHAKEIVSILQSCPH-LSEV--------------- ----------------------------------------------D--LSDNKLGDEGC SFLLENLSWISISKQLNLSHNLLSVTGIYSLLKAVNTCQRVVEVEVSLYHNTAVLRFTED GEFASPP----AREEPLYPTDDQWDDKENQTPVPSKKIRLTYCRFQASDLEKLCAVLKEC GSI--SELDPSLSNNYLGDEGLAQL---LQFLPNL-KTLRSLKLNN--NHLSLSSVFCLA QSLCTLEHLETMDLRYDQEYLSCHFLLEDLKAWLRLWSRQQYPSDEGYASKIYVVKLRGL PRALSLRNCTVGPEDVTRLCQMLMQCTQLTEIDLCGNALNDQSIERLLSFLPHFCQLTLL SIRNNTFSPCCAVLFANSINLCERIRRVEVRSSQNAFLHLRTSTQGQKTSC-RLTDCAIG QRQIEKLCRVL-EQHGCLAELDLSRNQLGDEVLRFLLDHLHRVPVTCSLNLSHNRISQRG VLHLINTFTTSGNTTEVQVSLCSKATLIIKMTSRDDPRKILRLTECSFQPEHLEKLCLVL ENCTNLTECIIPQFCWLTLEPQEPGFFSLL------------IEEPWVCKLSVTSLLELA VQAHGNITAIMICKEKNLFQLGVRLPHCLEKVGSVVSRLNLNEPEIKQACFYQRVHDKCT QLQELRWSHVEL----HDDTEMLVSILLPLPDLKKFELTSCSFTPTGIDCLITGLQRCQA IEELNMNRLQIGKKQQFLFT-------------------------------CNEGWVGET SLGHMKLGDAAIPKLVFGLCEMPSLKRL--ILNHNSIGDDGCSRLAEALS---------- ---------------------------------------------------SMHCMEEIN ------------------------------------------------------------ ---------------------------------------------LGHNK-IGDLGLIN- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------IAAVLLEMQNLK RIDLSGNCPSPAGGEKLMEALANCKHLEELI----LSRNDFGDGTAVKLALCLP------ ---------------------------------------- >P_pygmaeus_ENSPPYP00000004039 ------------------------------------------------------------ --------------------------------------------------MAD-SSSSFF PDFGLLLYLEELNKEELNTFKLFLKE--------TMEPEHGLTPWTEVKKARREDLANLM KKYYPGEKAWSVSLKIF------GKMNLKDLCERAKEEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WSAQNIGPD DAKAGETQ-------------DQEAVLGDGTEYRIRIKEKFCITWDKKSLAGKP------ -EDFHHGIA-----------------------------------------------EKDR KLLEHLFD-V--------DVK--TGEQPQVVVLQGAAGVGKTTLVRKAMLDWAEGNLYQQ RFKYVFYLNGREINQ--------LKERSFSQLISKDWPSTE-----GPIEEII-SQPSSL LFIIDSFDELNFAF-EEPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL TTSKRLKQLLKNHCYVELLGMSEDARQE-YIY---QFFED-----------------K-- -RWAMKVFSSLKSNEMLFSMCQVPLVCWATCTCLKQQME----KG----GDVTL-ICQTT TALFTCYISSLFTP--VDG---------------RSPSLPNQAQLRRLCQVAAKGIWTMT YVFYRENLRRL--------------GLTKSDVSS-F--MDSNIIKKD----A---EYENC YVFTHLHVQEFFAAMFYMLKGNWEAWN--------------------------------- -----------------PSCQPFEDLKSLLQ-STSYK----------------------- -------DPQLTQMKCFLFGLLNEDRVKQLERTFN--CKMS-L-KIKSKLLQCMEVLGNS ---------------DYSPSQLGFLELFHYLYETQDKAFISQAMRYFP-K-VAV--NI-- ------------------------------------------------------------ -----CEKIHLLV----S-------SFCLKHCR---CLRTIRLSVT-GVFEKKILKTSLP TNTW---------DGDRITHCWQDLCSVL----HTNEHLR----------QLDLCHS--- NLDK-----SAMNILHHELRHPNCKLQKLLLESCNLTVFCCLNISNALI-RSQSLIFLNL STN-NLLDD-GVQLLCEALRHPKCYLERLSLESCNLTVFCCLNISNALIRS-QSLIFLN- --LSTN-NLLDDG-VQLLCEALRHPKCYL------------------------------- -ERLS----------LESCG--LTEAGCEDLSLALISNKR-LTHLCLADNVLGDGGIKLM SDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHL----D--LGSNWLQDNGV KLLCDVFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTNACCLDL---ASVILIN-PNLRSLDLGN--NDLQDDGVKILC DALRHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--ELEYCGLTSLCCQDLSSALI---------- ---------------------------------------------------CNKRLIKMN ------------------------------------------------------------ ---------------------------------------------LTQNT-LGYEGIVK- ----LY------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVLKSPKCK---LQVLG----LCKEAFDEEAQ-KLLEAVGVSNPHL IIKPDCNYHNEEDVSWWRCF-------------------- >G_gorilla_ENSGGOP00000009679 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FTSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------EGKSQPESQLHH ---------------------------ELAKKYLQLLRTSAQQRYRSQIPGSGQP----- -HAFHQVYV---P------------PILR--RATASLDTPEGAIMGDLKVED-----GAD VSISDLFNTR-------------VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNC- -FQALFLFEFRQLNL-------ITRFLTPSELLFDLYLSPESDHD-TVFQYLE-KNADQV LLIFDGLDEALQPM--------------GPDGPGPVLTLFSHLCNGTLLPGCRVMATSRP GKLPACLPAEA--AMVHMLGFDGPRVEE-XVN---HFFSA-----------------Q-- -PLREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLP------DXAPGQSVA-LLPTM TQLYMQMVLALSPP-----------------------GHLPTSSLLDLGEVALRGLETGK VIFYAKDIAPP--------------LIAFGATHS-L--LTSFCVRTG------PGHQQTG YSFTHLSLQEFLAALHLMASPKVNKDTLTQYVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------XGLSDHLPTFLAGLASCTCRPFLSHLAQG-NEDC-VGAKQAAVVQVLKKLA-- ---------------TRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQ-LPFHNFP-- ------------------------------------------------------------ -----LTCTDLAT----L-------TNILEHRE---APIHLDFDGC-PLEPH-------- ------------------------CPEAL----VGCGQIE----------NLSFKSR--- KCGD-----AFAEALSRSLP------------------------------TMGRLQMLGL AGS-KITAR-GISHLVKALPLCP-QLKEVSFRDNQLSDQVVLNIVEVLPHL-PRLRKLD- --LSSN-SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQXXXXXXXX XXXXXXXXXXXXXXXLQKCQ--LQVHDAEALIALLQEGPH-LEEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAASQLHITRKLXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXX----XXXXXXXXX--XXXXXXXXXXXXXXXXXLTHCGLQAKHLEQLCKALGGS CHL--GHLHLDFSGNALGDEGAARL---AQLLPGL-GALQSLNLSE--NGLSLDAVLDLV RCFSTLQWLFRLDISFESQHILLRG-----DKTGRDIWATGSSPDFPAAAEFLGFRQRCI PRSLCLSECPLEPPSLTRLCATLKDCPGPLELXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRFTGCSLS QEHVESFCWLL-SKCKDLSQVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXXXXX XXXXXXXXXXXISETQQQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCA RLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLARLASGLGHCHH LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSHMTCLQSL RLNRNSIGDVGCCHLSEALRAATSLEEL--DLSHNQIGDAGVQHLATILP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSVNS-ISSAGGVQ- ------------------------------------------------------------ LAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQA LDGSPHLEEISLAENNLAGGVLRFCKELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALE VILLSWNLLGDEAAAELAQVLPQMGRLKRVD----LEKNQITALGAWLLAEGLAQGSSIQ VIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQPQA-PWGT >T_rubripes_ENSTRUP00000005495 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LKRRCEHVTEGTNEAGSG------ -TLLNKIYA---E------------LYITEGQSEEV-DTQHEVRQLEIT--SKKNLQDTP IKCQEIFK-V--------LSE--QQRHIRVVLTNGVAGVGKTFSVQKFSLDWAEGLENQD -ISLVLPLSCRELNL------IRDEQHSLLSLLHVFHPTLQ-----KIRAEDL-T-VWKL LFIFDGLDESRFSL-DFNKH----QVISDVTQVSSVEVLLVNLIQGNLLPSALIWITSRP AAAYQIPPSCVD-RITEVRGFTDSQKEE-YFR---RRFSD-----------------E-- -DLSKRIISHIKASRTLHIMCLIPVFCCITAIVLEDMMT---------RDQRGE-LPKTL TDLYSHFLMVQIKR--KKQ-KYGG--KQ----RPEELTEADKELLLKLGRLAFEHLEKGN IIFYSEDLEQC--------------GLDVSEVSV-YSGVCTEIFKRE----S-VIFQKSV YCFVHLSIQEFLAAVYMFHCYTRKDTVVINQFLKY------------------------- -----ISGFTWLYTNNDPVTSLDDFL---------SK----------------------- -------NGHLDLFVRFLHGLSLESNQRILGGLLDQ-TESH-P-ETIQKVLNNLKEVN-- ---------------SDKVSPDRSINIFHCLTEMKDQSVHQEIQEFLK-S-KRKSERR-- ------------------------------------------------------------ -----LSEIHCSA----L-------AYLLQMSE--EVLDELNLQQY-NTSEEGRRRLI-- ---------------------------------PG------------------------- ------------------------------------------------------------ -----------------------CILSLFSLSSCSLSEISCDSLASALRSNPSHLRVLD- --LSYN-SLEDSG-VKLLCSGLESLNCKL------------------------------- -ETLR----------LIDCS--LSEISCDFLASALRSNPSHLRVL--------------- ----------------------------------------------D--LSWNQLKDSGV KQLCGFLQDPL------------------------------------------------- ------------------------------------------------------------ CRL--ETL--SLIDCSLSAISCDCL---SSALRSNPSHLRVLELND--NNLEDSGVKPLS DLVESPI----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------YKLETL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000013907 ------------------------------------------------------------ -----------------------------------------MDPVGL-------QLGNKN LWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSF IHCVCMQLEVPLDLEVL------LLSTFGCDDGFTSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------EGKSQPESQLHH GLKRPHQSC---GSSP-RRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQP----- -HAFHQVYV---P------------PILR--RATASLDTPEGAVMGDLKVED-----GAD VSISDLFNTR-------------VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNC- -FQALFLFEFRQLNL-------ITRFLTPSELLFDLYLSPESDHD-TVFQYLE-KNADQV LLIFDGLDEALQPM--------------GPDGPGPVLTLFSHLCNGTLLPGCRVMATSRP GKLPACLPAEA--AMVHMLGFDGPRVEE-YVN---HFFSA-----------------Q-- -PSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLP------DHAPGQSVA-LLPTM TQLYMQMVLALSPP-----------------------GHLPTSSLLDLGEVALRGLETGK VIFYAKDIAPP--------------LIAFGATHS-L--LTSFCVPTG------PGHQQTG YAFTHLSLQEFLAALHLMASPKVNKDTLTQYVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------LGLSDHLPTFLAGLASCTCRPFLSHLAQG-NEDC-VGAKQAAVVQVLKKLA-- ---------------TRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQ-LPFHNFP-- ------------------------------------------------------------ -----LTCTDLAT----L-------TNILEHRE---APIHLDFDGC-PLEPH-------- ------------------------CPEAL----VGCGQIE----------NLSFRSR--- KCGD-----TFAEALSRSLP------------------------------TMGRLQMLGL AGS-KITAR-GISHLVKALPLCP-QLKEVSFRDNQLSDQVVLNIVEVLPHL-PRLRKLD- --LSSN-SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRA-DLQES DGQRKGAQSRSLTL-LQKCQ--LQVHDAEALIALLQEGPH-LEEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAASQLHIARKLD------------------------------LQHKTVIFMFAQE PEEQKGP----QERAAFLDS--LMLQMPSELPLSSRRMRLTHCGLQAKHLEQLCKALGGS CHL--GHLHLDFSGNALGDEGAARL---AQLLPGL-GALQSLNLSE--NGLSLDAVLGLV QCFSTLQWLFRLDI--------------------RDMWATGSLPDFPAAAEFLGFRQRCI PRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLL QLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNQEEEGMCCGRFTGCSLS QEHVESFCWLL-SKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLELS-------- --------------------------------------------ECSFRPEHVSRLATGL SQSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLR----VQEPWADRAGVLSLLEVC AQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCA RLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHH LEELDLSNTQLDEEGTKALMSALEGKWMLKRLDLSHLLLNSSTLALLTHRLSHMTCLQSL RLNRNSIGDVGCCHLSEALRAATSLEEL--DLSHNQIGDAGVQHLATILP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSVNS-ISSAGGVQ- ------------------------------------------------------------ LAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQA LDGSPHLEEISLAENNLAGGVLRFCKELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALE VILLSWNLLGDEAAAELAQVLPQMGRLKRVD----LEKNQITALGAWLLAEGLAQGSSIQ VIRLWNNPIPCDMVQHLKSQEPRLDFAFFDNQPQA-PWGT >H_sapiens_ENSP00000299481 ------------------------------------------------------------ --------------------------------------------------MADSSSSSFF PDFGLLLYLEELNKEELNTFKLFLKE--------TMEPEHGLTPWNEVKKARREDLANLM KKYYPGEKAWSVSLKIF------GKMNLKDLCERAKEEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WSAQTIGPD DAKAGETQE------------DQEAVLGDGTEYRNRIKEKFCITWDKKSLAGKP------ -EDFHHGIA-----------------------------------------------EKDR KLLEHLFD-V--------DVK--TGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQ RFKYVFYLNGREINQ--------LKERSFAQLISKDWPSTE-----GPIEEIM-YQPSSL LFIIDSFDELNFAF-EEPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL TTSKRLKQLLKNHHYVELLGMSEDAREE-YIY---QFFED-----------------K-- -RWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQME----KG----GDVTL-TCQTT TALFTCYISSLFTP--VDG---------------GSPSLPNQAQLRRLCQVAAKGIWTMT YVFYRENLRRL--------------GLTQSDVSS-F--MDSNIIQKD----A---EYENC YVFTHLHVQEFFAAMFYMLKGSWEAGN--------------------------------- -----------------PSCQPFEDLKSLLQ-STSYK----------------------- -------DPHLTQMKCFLFGLLNEDRVKQLERTFN--CKMS-L-KIKSKLLQCMEVLGNS ---------------DYSPSQLGFLELFHCLYETQDKAFISQAMRCFP-K-VAI--NI-- ------------------------------------------------------------ -----CEKIHLLV----S-------SFCLKHCR---CLRTIRLSVT-VVFEKKILKTSLP TNTW---------DGDRITHCWQDLCSVL----HTNEHLR----------ELDLYHS--- NLDK-----SAMNILHHELRHPNCKLQKLLLKFITFP-DGCQDISTSLI-HNKNLMHLDL KGS-DIGDN-GVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRS-QSLIFLN- --LSTN-NLLDDG-VQLLCEALRHPKCYL------------------------------- -ERLS----------LESCG--LTEAGCEYLSLALISNKR-LTHLCLADNVLGDGGVKLM SDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHL----D--LGSNWLQDNGV KLLCDVFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTNACCLDL---ASVILNN-PNLRSLDLGN--NDLQDDGVKILC DALRYPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--GLEYCGLTSLCCQDLSSALI---------- ---------------------------------------------------CNKRLIKMN ------------------------------------------------------------ ---------------------------------------------LTQNT-LGYEGIVK- ----LY------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVLKSPKCK---LQVLG----LCKEAFDEEAQ-KLLEAVGVSNPHL IIKPDCNYHNEEDVSWWWCF-------------------- >T_rubripes_ENSTRUP00000033190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LKRRCEHVTEGTHEAGSG------ -TLLNKIYT---E------------LYITEGQSEEV-DTQHEVRQLERT--SKKKIQDTP IKCQDIFK-V--------LSE--QQRHIRVVLTNGVAGVGKTFSVQKFSLDWAEGLENQD -ISLVLPLSCRELNL------IRDQQHSLLSLLHVFHPTLQ-----KIRAEDL-T-VWKL LFIFDGLDESRFSL-GFNKH----QLISDVTQVSSVDVLLVNLIQANLLPSALIWITSRP AAAYQIPPWCVD-RITEVRGFTDSQKEE-YFR---RRFSD-----------------E-- -DLSKRIISHIKASRSLHIMCLIPVFCWITAIVLEDMMT---------RDQRGE-LPQTL TDLYSHFLRVQIKR--KKQ-KYGG--KQ----RPEELTEADKDLLLKLGRLAFEHLEKGN IMFYSEDLERC--------------GLDVSEVSV-YSGVCTEIFKRE----S-VIFQKSV YCFVHLSVQEFLAAVYMFHCYTRNDTAVINQFLKY------------------------- ---------------SKPVKSLDDFLRRALMKSLESE----------------------- -------NGHLDLFVRFLHGLSLESNQRILGGLLDQ-RNSH-P-ETIQKVLNNLKEVN-- ---------------SDEFSPDRSINIFHCLMEMKDQSVHQEIQEFLN-C-EELQEVRRV DHVIKSLLFVCIHRILTTGGN-------FITSNKRCSENDLKGNRQIEQKLRAIDATRDS DVIDRIAENRLSGDFFQR-------VIAMTSNP--SHLRELSLSWNQSPTDADVKLLFSA MMH------------------------------PNSRLET-----------LRLWDC--- SLSE-----ISCDSLGLALRS-----------------------------NPSHLRVLDL GGN-QLQDP-GVKLLCGALQDPLCKLETLRLRRCSLSETCCDSVASALKSNLSHLRVLD- --LSHN-TLQDSG-VKRLCSGLESPNCKL------------------------------- -ERLS----------IVNSG--LTQISCGSLASALRSNPSHLREL--------------- ----------------------------------------------D--LSWNLLQDSGV KLLCGFLHFPN------------------------------------------------- ------------------------------------------------------------ CRL--ETL--RLWNCSLSETSCDSL---ASALRSNPSHLRELDLSR--NQLKDSGVKLLS DLVK-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >C_familiaris_ENSCAFP00000022816 ------------------------------------------------------------ --------------------------------------------------------MACR VQWQLAWYLEMMGKEELKEFQLRLLEQ-------QFWGDPPHALRAQLGKARGLEVASRL VAQYGEQQAWVLALRTW------EEMGLSRLCAQSRAEAGLIPLS--PGSPM-APSMQSP NSPISTEVL----RFIQDPRTRNSGQPLPPLLPNTSGHMWNEDPSSCKYQEGLPDSPEFQ GSPHQESPSAPMPTAVLGGWEAPPQPSPVPGKQEAPKAGWPVAGTSGNHNPGERNRSQTE SPQGRSVPY---LYVPSFPPLA-----GITERYQHQRRKKPYPTWSWED----------- -KDLHQIFI---Q------------LLLLHQPY----PRGHESLTKGRWHHG-AEKQGHL IEVEDLFG-P--------GLG--AQEEPQTVILHGVAGIGKSTLARQIRTAWKEGQLYKD RFRHVFYFNCRELAR--------SETMSLTELITKAQAGPV-----LPAEQIL-SQPGRL LFILDDLDEPRWVL-GEQES----ELHSSWSKQRPVHALLGSLLGKTVLPEVSLLVTVRT TALRRLVPSVGQLCWVEVLGFSESGRRE-YFY---KYFKN-----------------K-- -SQATQAFSLVELNPTLLTMCLVPLVSWLLCTCLKKQMQ----RG----EELSLGSSQTT TALWLYYLSQALPA------------------------QLLGAQLRGFCSLAAEGFWQGT NLLSRRDLRKH--------------GFDEATIST-F--LKTGILRKH--------PSPLN YHLAHRCLQEFFAAVSCVLGGEDGGSP--------------------------------- ------------------HPDSIRGAEKLLE-VYEGH----------------------- -------DLFGAPTTHFLFGLLSEQGEREMEAVFQ--CKLP-R-ERKRDLLRWAEAGLWP ---------------RLSAPQPCSLHLLHCLYEIQDEDLLTRAMAHFH-G-RSM--CV-- ------------------------------------------------------------ -----QTGVEFLV----C-------TFCFKFCS---HVKRLQLNES-RWDG--------- ---------------------------------QAWRPSS----------VALFSWV--- PVTD-----ACWQALFSTLR------------------------------ASGSLKELDL SGN-HLSHP-AVQSLCKVLKFPCCHLETVRLAGCGLTAEGCSDLASALSAS-PALAELE- --LSFN-LLLDAG-AQHLSRGLRQPACRL------------------------------- -RRLL----------LAGCS--LTSRCCGALASALSTSPL-LTEL--------------- ----------------------------------------------D--LQQNELGDVGV RLLCGGLGHPT------------------------------------------------- ------------------------------------------------------------ CQL--TLL--WLDQTQLSEEMTQML---RALQEEK-PQLFVCSKWK--PRATVPTEGLSR GETS-GT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKQQ--RQGSGRKSNAVAQARQPSLDRESGADSCSA PFPERSCPQVGQVQLGRPPSPAAPWDLNTEPLRIGDGFWGPLGPVAPEWLAEDGSLYRVH LPVAGSYHWPDTGLRFEVRGPATIDIEFCVWDQHLPRAGLWHSWMVAGPLFDIKAEPGAV ATVCLPHFVDLQGSSVDTSLFYAAHLKDEGMLVETPARVEADHVVLENPS-FSPIGVLLR TIHAALRFLPVTCVVLLYHHLRPGEVAFHLYLIPSDYSIRKAIDNEEKKFQFVQIHKPPP LASLYMGSRYTVSGSEK--LEIIPKELELCYRSPREPQLFSEFYVSHLGSGIRLQVRDKK DDTVVWEALVKPGDLRPVASLAPPAPAAR-PFPTDAPAWLHFVDRHREQLVARVTSVDPV LDMLHGQVLSEEQYERVRAEATTPSQMRKLF----SFSRSWDRACKDQVYQALKEAHPHL IMELWEKWGGNSGKQAPPG--------------------- >T_rubripes_ENSTRUP00000004389 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ECQNKLKSLLKRRFERVVEGDARRKNS------ --SLDQIYT---D------------LFHTEGGTGDV-ISEHEVRQIESA-SRKQNKHETK IGCENLFK-P--------DLG--RQEPIRSVMTKGIAGIGKTVFTQKLALDWAKGKVNQD -IQFMFPIAFRELNL------LKDKKYSLMELLKLLFPGTI-----EKMISGL-E-EFRV LFIFDGLDEFRLSL-DFQAH----EIITDVTQSASVDMLMTNLIRGNLIPSAQIWITSRP ATANQIPPHYID-RMTEVRGFNDEQKDQ-YFR---NRFRD-----------------E-- -EQASRVLSHIKTSRSIYIMCHIPIFCWITAKVLEN------------TREGRE-LPKTL TEMYIYFLEVHFKL--KNL-KHNGQSAT-----APTWSPESSSMIMSLGKLAFEHLQKDN LIFYQSDLMEC--------------GIDIKEASV-SSGVLTEIFKEE----P-LSFQGTV FCFIHLSVQEFLAALYVHLMFFNSN----------------------------------- ---------------------------SAVEMALKNP----------------------- -------KGHLDLFLRFLLGLSIPDNQNILQGLVPQ-GGT----LQTQEIVAYIKTKI-- ---------------DEGLSQERSINLFHCLNELKDHSTLEEIQKFIN-C---------- ------------------------------------------------------------ -----------------L-------LCFLVSSS--------------------------- ---------------------------------------------------FRMSCC--- NLSE-----KSCEVLGPVLSS-----------------------------HCYSLTKLDL SNN-NLQDS-GVKLLCAGLESPHCTLEVL------------SSLASALRSNPDHLLELD- --IRYN-HLGDSG-VRLLTARLEDPTCAL------------------------------- -NTL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_mulatta_ENSMMUP00000026833 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------RLLLVKEHSNPMQAQQQLLDIGRGHTRTVGHQASP IKIETLFE-P--------DEE--RPEPPRAVVMQGVAGIGKSMLAHKVMLDWADGKLFQG RFDYLFYINCREMNQ-------SDTECSMQDLISSCWPEPS-----APLQELV-RVPERL LFIIDGFDELKPSF-HDPQG----PWCLCWAEKRPTELLLNSLIRKKLLPELSLLVTTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHD-----------------T-- -EQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLE----GG----GLLKQ-TSRTT TAVYMLYLLSLMQP--KLR----------------TARLQPPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGADVSA-F--LNMNIFQKD----I---NCERY YSFIHLSFQEFFAAMYYILDDGERGAG--------------------------------- ---------------------PDQDVIRLLTEYGFSE----------------------- -------RSFLALTIRFLFGLLNEETRSYLENSLC--WKVS-P-HIKRELLQWIRSKAQS ---------------DGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQ-V-IVV-S---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_domestica_ENSMODP00000011060 ------------------------------------------------------------ ------------------------------------------------------------ ----LVRYLEELTFEELKKFKLFLEDS-------PPKEKFLRIPRSQMKKADNTDMAELM VHHYGEGEAWDVALMIW------EKMGLRELWEQAKREAP-------------------- ------------------------------------------------------------ ------------------------------------------------QMGKYGETFAYK DERLGHREN------------KSQRILSCQTTYRNRIMEKFRVMRDRNSCPGEY------ -ENLHHRFT----------------RLLL----------------------------LQE YQVASLFD-P--------DKK--REAHPQVVVLQGAAGIGKTTLARKVILDWAEGNLYQD KFDYVFYLHCREMNH------LREKKIRFADLIANDWPFLE-----ASMKRIL-SHPEKL LFVIDGLDELKFSC-DEHSY----DLCKDWNLQQPVPILLSSLLRKTMLLESSLLITTRL TALEKCDFLFENPRHVEILGFSEEDRWK-YFC---KFFGD-----------------E-- -DQAQQAFSLIVNNETLFTMCFVPLMCWIICTCMKQQMR----RK----KDLKQ-ASKTT TTLYMCYLSSLATP--GAR-------------------SCSVQHHRSLCRMAAEGIWEGK ILFDGDDLRRH--------------GLEASDVSA-F--LDMHIFQKD----S---DSENC YSFIHLSFQEFFAAMFYALGEEKETGG--------------------------------- -----------------RAVPPIPGVKDLLAKCRDSA----------------------- -------TSFVALTVHFLFGFLNADNRKRLEEIYD--CKIS-Q-EIKLELLQWIQAVTEQ QH-------------KDPSLRNDLLEMFSHLYETQDEEFVTTAMAHFQ-E-ISL--NI-- ------------------------------------------------------------ -----YSKLHFLI----S-------VFCIKFCH---NLGKIRLNIA-WMYRSKIQSAGIT QTWQ-------LPFFQLAVVDWQHLFSVL----SKNQNLR----------TLDLSGT--- ELAN-----SAVNALCSELSQSSCKLQKLSLSKCQLTASCCQHLSSLLK-NNKNLTYLDL SMN-FLGDE-GIKALCEVLRNQNCNIQELNLSRCRFSDACCKNLSSALMAH-GNINILD- --LSEN-TLADVG-MNLLCEALGSSDCNL------------------------------- -QELK----------LSQCH--FTDACCQDLSTCI-KNQS-LIHL--------------- ----------------------------------------------D--VSGNFLQDSGI RLLCEALRHPT------------------------------------------------- ------------------------------------------------------------ CNL--QKL--LLSLCHITDSSCQDV---SFALKNN-RSLIHLDLGC--NNLYNHGVKLLC EALENQN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLQTL--ELWNCQLSAACCHEFSSVLK---------- ---------------------------------------------------KNQSLTHLN ------------------------------------------------------------ ---------------------------------------------LGANP-LRNNGVKV- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EALGNQNCK---LQKLK----LCKCLLSAVGC-RYLSTALKSNQNL THLKLTGNGLGDDGVKLLFEALKNSDCKLQKL-------- >M_domestica_ENSMODP00000015678 ------------------------------------------------------------ --------------------------------------------------------MADT ILCCLVTYLEELECGELSKFKMYLGLE-------AEREGEERVPRGRMEKAGPLDLAKIL VAQWGPAEAWELALRVF------NRINRKDLWERGCQEPL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRASG PTGPSGNGK------RRKMMMMEEPRKNPQETYREHVRRKYRFIEDRNARLGEL------ -VNLSQRYT----------------RLLLVKEHATLIRAQRELLALGRQHALCLDQRASP IHIETLFE-P--------DEE--RPEAPHSVVLQGAAGIGKSILAQKVMLDWAEGHLYSD RFDYLFYVNCREMNQ--------VRERSLEDLISLCWPERN-----VPISEIV-RVPERL LFIIDGFDELQPFF-HEPTD----CCCLRQGERRPVEALLSCLLTRKLLPERSVLITTRP TTLETLRHLLEHPRHVEILGFSEAQRQE-YFY---KFFGN-----------------E-- -EQARQGLAVVRDNEPLFTLCFVPMMCWIVCTCLKQQLD----VG----RPFPH-TSKTT TAVYMFYLLSLLQP--KAG----------------GSRAQPPPSLRGLCSLAAAGLWRQR ILFDEDELRRH--------------GLEAAHVSA-F--LNMNVFHKD----I---QRERY YSFIHLSFQEFFAAMFYALEGELGASP--------------------------------- -----------------------AGLTGLLDHYAKCE----------------------- -------RSSLALAVRFLFGLLNEETRGYLDRRLG--WRIS-P-RTKRDLLRWIRAKARS ---------------EGSTLQRGALELFTCLYEIQEEDFIQRALDYFQ-V-VVV-SEM-- ------------------------------------------------------------ -----ATKMEHVA----S-------SFCVRNCW---SALVVHLCSA-PFSADGEQEPEGA EGPQNQPLKP-SEKNILPETYCEHLAAAL----STNRNLV----------ELVLYRN--- ALGD-----RGVRLLCQGLRHPNCQLQNLRLKRCRISAAACQDIAAALV-TNPNLIRLDL SRN-VLGAA-GVRLLAGGLLHPRCRLQMLQLRRCHVDGEACQELSKVLSTS-QHLAELD- --LTGN-ALGESG-LQLLCPGLGHSACKL------------------------------- -QTLW----------LKICH--LTPAACQNLSSVLSTNQS-LTEL--------------- ----------------------------------------------D--LSLNDLGDAGV TSLCEGLCHSK------------------------------------------------- ------------------------------------------------------------ SQL--HTL--RLGICRLTFVSCEAL---STTLQSN-VHLKALDVSF--NDLEDMGVHLLC EGLQHPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQKL--WLDSCCLSGAACRDLASALG---------- ---------------------------------------------------ANQTLRELY ------------------------------------------------------------ ---------------------------------------------LTNNA-LGDAGVQL- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QRLSQASCR---LRTLW----LFGTELTDGTQ-QALAALRGSKPHL DIGS------------------------------------ >T_rubripes_ENSTRUP00000037843 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LRKKFQCLFEGVPKAGEP------ -RFLNEIYT---E------------LSISQACGEEV-KDLQEFRDIEA--SRTTQSAPTS ATCEKMFS-P--------LFE--PDGSVRTLLTKGVAGIGKTVLTQKFILDWAEEKVNQG -IQLIFPFTFRELNL------MKERKCSLVELLHRFFIETK-----EAEICRF-E-NFQV LFIFDGLDECRLHL-DFRNS----QIVTDAMEGTSVEVLLTNLIKGTLLPTARLCITTRP AAASQIPPEFID-MVAEVRGFGELQKQE-YFH---KKVKK-----------------R-- -EQARRIISHIETSRSLQIMCRVPVFCWISAEVLDHLLK---------TQDISN-FPQTL TNMYLHFLVVQTTK--ANE-KYHTSVPT-----DALWNQETKKTIFTLGKLAFDNLEKGN IVFYQSDLETY-------------------------------MADDR----T-RLKQEKV FCFVHLSIQEFLAALYVLLTFINNGIDLLRKKQFP------------------------- ---------PELCVPLQFKTNLKKLFQTAINKALHCP----------------------- -------NGDLDLFVRFLLGLSLHTNQSVLRGLLLK-AGST-S-QIKKDLVKYIKKKL-- ---------------GECPSPERSIYLLECLNELNDQSLEEEIQQSVR-P-GRIFEDQ-- ------------------------------------------------------------ -----PSPSQWSA----V-------AFILLSSQ--QQLDIFDLRTF-SASDEG------- ------------------------LLWLR----PVVKASK----------RAVLSDS--- SLSS-----KSCQALVPVLSS-----------------------------KNCSLRELDL SNN-DLYDA-GVTLLSVGLTSPNCRLETLRLSGCHIGETGCKNLALALESNPAHLRELD- --LSFN-HPGDSA-LELLSAAVKNPRWKL------------------------------- -ETLKGVR-------MGSC--------CTALAGAKQANRG-LQQL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >T_rubripes_ENSTRUP00000011348 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RVVLTNGVAGVGKTFSVQKFTLDWAEGLENQD -ISLLVLLSFRELNL------IKDEQHSLLSLLHVFHPTLQ-----KIRAEDL-A-ACKL LLIFDGLDESRLSL-DFNKE----QVISDVTQVSSASVLLVNLIQGNLLPSALIWITSRP AAANQIPPSYVD-RITEIRGFTDTQKEE-YFR---RRFRD-----------------E-- -DLSKRIISHIKASRSLHIMCLIPVFCWITATVLEHMLT---------TEQRGE-LPKTL TDLYSHFLLVQTKR--KKQ-KYGG--HK----GPEELTESDKEVLLKLGRLAFEHLENGN ILFYQNDLEQC--------------GLDVSEVSV-YSGVCTEIFRRE----T-VIFQKSV YCFVHLSIQEFLAAVYVFHCYTSKNTAVIHSFV--------------------------- ---------------------------KVMMKSLESP----------------------- -------NGHLDLFVRFLHGLSLESNQRILGGLLNQ-TDNN-P-ETIQKVINNLKEMS-- ---------------SEQISPDRSINIFHCLMEMKDHSVHQEIQEFLK-S-EKNSEQE-- ------------------------------------------------------------ -----LSEIQCSA----L-------AYLLQMSE--EVLDELNLKEY-NTSEEGRRRLI-- ---------------------------------PAVRNCRSMFYINKSIRNLTKDSA--- LRVRTFQFLTSCMKFLDLLKNIQIIFDLFGVKYIYWF-------------TNINKIILKL SYN-QLQDS-GVKLLCSGLENPNCKLETLGLSSCSLSEISCGSLASALKSNTSHLRELN- --LSQN-RLQDSG-VKLLCSGLESPNCKL------------------------------- -ETLR----------LWGCS--LTEISCGSLASALKSNLSHLRLL--------------- ----------------------------------------------D--LSYNQLQDSGV KLLCSGLERPN------------------------------------------------- ------------------------------------------------------------ CKL--ETL--RLSSCSLSEISCGSL---ASALKSNLSHLTELDLNE--NQLQDSGVKLLC SGLESPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLETL--RLWSCSLSEISCGSLASALK---------- --------------------------------------------------SNPSHLRELD ------------------------------------------------------------ ---------------------------------------------LNENQ-IQDSGVKL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LSDLVKIQQFCSPKLRSIE----VTSF--------------------- ---------------------------------------- >P_troglodytes_ENSPTRP00000005793 ------------------------------------------------------------ --------------------------------------------------MADSSSSSFF PDFGLLLYLEELNKEELNTFKLFLKE--------TMEPEHGLTPWTEVKKARREDLANLM KKYYPGEKAWSVSLKIF------GKMNLKDLCERAKEEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WSAQTIGPD DAKAGETQE------------DQEAVLGDGTEYRIRIKEKFCITWDKKSLAGKP------ -EDFHHGIA-----------------------------------------------EKDR KLLEHLFD-V--------DVK--TGEQPQIVVLQGAAGVGKTTLVRKAVLDWAEGNLYQQ RFKYVFYLNGREINK--------LKERSFAQLISKDWPSTE-----GPIEEII-SQPSSL LFIIDSFDELNFAF-EEPEF----ALCEDCTQEHPVSFLMSSLLRKVMLPEASLLVTTRL TTSKRLKQLLKNHHYVELLGMSEDAREE-YIY---QFFED-----------------K-- -RWAMKVFSSLKSNEMVFSMCQVPLVCWATCTCLKQQME----KG----GDVTL-TCQTT TALFTCYISSLFTP--VDG---------------GSPSLPNQAQLRRLCQVAAKGIWTMT YVFYRENLRRL--------------GLTKSDVSS-F--MDSNIIQKD----A---EYENC YVFTHLHVQEFFAAMFYMLKGSWEAGN--------------------------------- -----------------PSCQPFEDLKSLLQ-STSYK----------------------- -------DPHLTQMKCFLFGLLNEDRVKQLERTFN--CKMS-L-KIKSKLLQCMEVLGKS ---------------DYSPSQLGFLELFHCLYETQDKAFISQAMRCFP-K-VAI--NI-- ------------------------------------------------------------ -----CEKIHLLV----S-------SFCLKHCR---CLRTIRLSVT-VVFEKKILKTSLP ANTW---------DGDRITHCWQDLCSVL----HTNEHLR----------ELDLCHS--- NLDK-----SAMNILHHELRHPNCKLQKLLLKFITFP-DGCQDISTSLI-HNKNLMHLDL KGS-DIGDN-GVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRS-QSLIFLN- --LSTN-NLLDDG-VQLLCEALRHPKCYL------------------------------- -ERLS----------LESCG--LTEAGCEYLSLALISNKR-LTHLCLADNVLGDGGVKLM SDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHL----D--LGSNWLQDNGV KLLCDVFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTNACCLDL---ASVILNN-PNLRSLDLGN--NDLQDDGVKILC DALRYPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--GLEYCGLTSLCCQDLSSALI---------- ---------------------------------------------------CNKRLIKMN ------------------------------------------------------------ ---------------------------------------------LTQNT-LGYEGIVK- ----LY------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVLKSPKCK---LQVLG----LCKEAFDEEAQ-KLLEAVGVSNPHL IIKPDCNYHNEEDVSWWRCF-------------------- >H_sapiens_ENSP00000262510 ------------------------------------------------------------ -----------------------------------------MDPVGL-------QLGNKN LWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSF IHCVCMQLEVPLDLEVL------LLSTFGYDDGFTSQLGA-------------------- ------------------------------------------------------------ ------------------------------------------------EGKSQPESQLHH GLKRPHQSC---GSSP-RRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQP----- -HAFHQVYV---P------------PILR--RATASLDTPEGAIMGDVKVED-----GAD VSISDLFNTR-------------VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNC- -FQALFLFEFRQLNL-------ITRFLTPSELLFDLYLSPESDHD-TVFQYLE-KNADQV LLIFDGLDEALQPM--------------GPDGPGPVLTLFSHLCNGTLLPGCRVMATSRP GKLPACLPAEA--AMVHMLGFDGPRVEE-YVN---HFFSA-----------------Q-- -PSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLP------DHAPGQSVA-LLPNM TQLYMQMVLALSPP-----------------------GHLPTSSLLDLGEVALRGLETGK VIFYAKDIAPP--------------LIAFGATHS-L--LTSFCVCTG------PGHQQTG YAFTHLSLQEFLAALHLMASPKVNKDTLTQYVT--------------------------- -------------------------LHSRWVQRTKAR----------------------- -------LGLSDHLPTFLAGLASCTCRPFLSHLAQG-NEDC-VGAKQAAVVQVLKKLA-- ---------------TRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQ-LPFHNFP-- ------------------------------------------------------------ -----LTCTDLAT----L-------TNILEHRE---APIHLDFDGC-PLEPH-------- ------------------------CPEAL----VGCGQIE----------NLSFKSR--- KCGD-----AFAEALSRSLP------------------------------TMGRLQMLGL AGS-KITAR-GISHLVKALPLCP-QLKEVSFRDNQLSDQVVLNIVEVLPHL-PRLRKLD- --LSSN-SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQES DGQRKGAQSRSLTLRLQKCQ--LQVHDAEALIALLQEGPH-LEEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQE PEEQKGP----QERAAFLDS--LMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGS CHL--GHLHLDFSGNALGDEGAARL---AQLLPGL-GALQSLNLSE--NGLSLDAVLGLV RCFSTLQWLFRLDISFESQHILLRG-----DKTSRDMWATGSLPDFPAAAKFLGFRQRCI PRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLL QLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLS QEHVESLCWLL-SKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQES ALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGL SKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLR----VQEPWADRARVLSLLEVC AQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCA RLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHH LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSL RLNRNSIGDVGCCHLSEALRAATSLEEL--DLSHNQIGDAGVQHLATILP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSGNS-ISSAGGVQ- ------------------------------------------------------------ LAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHLGPGGALSLAQA LDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALE VILLSWNLLGDEAAAELAQVLPQMGRLKRVD----LEKNQITALGAWLLAEGLAQGSSIQ VIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQPQA-PWGT >E_caballus_ENSECAP00000009788 ------------------------------------------------------------ --------------------------------------------------MTDSLSSSFF PDFGLLLYLEELNKEELNKFKLLLRNA-------TMEPEHCQIPWAEVKKAKREDLANLM NRYYPGEQAWDVALKIF------GKMNLKDLCERAKAEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WTTQSMGPE DARAGEAQG------------DQEAVLGDGTEYRSRIKEKFCIMWDKECLLGEP------ -KDFCHEIA-----------------------------------------------QKGQ ELLEHLFD-V--------DVK--TGEQPQTVVLQGAAGVGKTTLVRKAMLDWAQGNLYQQ RFAYVFYLNAREINQ--------LRERSFVQMISKDWPSTE-----GPIERIM-SQPSSL LFIIDSFDELNFAF-EEPEF----ALCEDWTQVHPVSFLMSSLLRKVMLPESSLLVTTRL TACKKLEPLLKSQRSVELLGMSEDAREE-YIY---QFFED-----------------K-- -KWALQVFGSLRNSEMLFSLCKVPLVCRVICTCLEQQME----KG------VTL-TCKTT TALFTCYISSLFTP--ADG---------------SCPSLPNQTQLRSLCHLAAKGVWTMT YVFYRENLRKH--------------GLTKCDVTI-F--LDVNILQKD----T---EYENC YVFTHLHIQEFFAAMFYILKDSMETRN--------------------------------- -----------------LFFQSFEDVKLLFE-SNSYK----------------------- -------DPHLMQMKCFLFGLLNEGLVKQLEDTFN--CKMS-L-GVKWKILQWMEILGNS ---------------DCFPSQLGFLELFHYLYETQDEGFISQAMRYFR-K-VVI--NI-- ------------------------------------------------------------ -----HGKIHLLV----S-------SFCLKHCQ---SLQTIKLSVT-VESERKMLNSSHS AETW---------DFGRITHYWQDLCSVL----HTNEQLR----------ELDLCHS--- NLDK-----LAMKTFYQELRHPNCKLQKLRLRFLSFP-DGCQDISRSLT-HNQNLMQLNL KGS-DIGDN-GVKSLCEALKRPECKLQNLTLESCDLTTVCCLDISKALVRS-QSLIFLN- --LSTN-NLLDDG-VKLLCEALRHPKCYL------------------------------- -ERLS----------LESCG--LTVAGCEDLSSALISNKR-LTHLCLADNNLGDGGVKLM SDALKHPQCTLQSLVLRRCHFTALSSEHLSSSLLHNKSLTHL----D--LGSNQLQDDGV KLLCDVFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTSACCLDL---SSAILNN-PNLRSLYLGN--NDLQDDGVKILF EALRHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--RLEYCGLTSLCCQDLSSTLS---------- ---------------------------------------------------SNQRLIKIN ------------------------------------------------------------ ---------------------------------------------LTQNT-LGCEGIMK- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKSPECK---LQVLG----LCKEALDEEAQ-KLLEAVGVSNPHL VIKHDCNDHNEEDDSWWRCF-------------------- >C_familiaris_ENSCAFP00000015730 ------------------------------------------------------------ ---------------------------------------------------------MAS VRCKLARYLEDLEDADFKKFKMHLQDY-------PSQKGFSPLPRSQTEKADHMDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLYEKAKRDEL-------------------- ------------------------------------------------------------ ------------------------------------------EWVLKTQNVDNSHLECRE ESLEEEWMG---LLGYLSRISICKKKKDYCKKYKKHVRSRFQCIKDRNARLGET------ -VNLNKRYT----------------RLRLVKEHQSQQEREHELLAIGRTSAKTLDSPMSS VNVELLFE-P--------DDQ--HLEPVHTVVFQGSAGIGKTILARKIMLDWASDKIYQD RFDYLFYIHCREVSL--------GTRRSLGDLIVSCCPDPN-----PPICKIV-SKPSRI LFLMDGFDELQGAF-DEHTE----ALCTNWQKVERGDILLSSLIRKRLLPEASLLITTRP VALEKLQHLLDRPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -QQATEAFRLIQENEILFTMCFIPLVCWIVCTGLKQQMD----SG----KNLAQ-TSKTT TSVYIFFLSSLLQS--HRE----------------TQKHQVSASLRGLCSLAADGIWNQK ILFDECDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEEEQGRM--------------------------------- -----------RNLPWSSSKLPNRDVKVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWIEEKAKG ---------------KNLQIQPSQLELFYCLYEMQEEDFVRKAMGHFP-K-IEI--SL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCC---RVESLSLRLL-HNSPWGLVSEEQI MQDTMG------------------------------------------------------ ---------RDMVSLEVIMRARACFVCSRTLVNCQVTVSLWQGLFSVLSRNSLSLTELNL SDN-ALGDQ-GVNVLCEMLQHPGCNIRKLWLGQCCLSYRCCFNISSVLSNN-QKLEELD- --LSHN-ALGDFG-IRLLCVGLKHLFCNL------------------------------- -NKLW----------LVSCC--LTPACCEDLASVLSTNQS-LTRL--------------- ----------------------------------------------Y--LGENSLEDAGV GVLCEKAKHPQ------------------------------------------------- ------------------------------------------------------------ CKL--QRL--GLVNSGLTPGCCPAL---ASMLSTN-QKLTHLYLRG--NALGDTGVKLLC EGLLHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQIL--ELDGCSLTSHCCWDLSTLLT---------- ---------------------------------------------------SSKSLRELS ------------------------------------------------------------ ---------------------------------------------LGSND-LGDLGVML- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQGCI---LQSLK----LCEMYFNYDTK-CALETLQEEKPEL TIVFEPFG-------------------------------- >B_taurus_ENSBTAP00000001675 ------------------------------------------------------------ -------------------------------------------------------MRMVS VRCKLARYLEDLEDIDFKKFKMHLEDY-------PSQKGCTSIPRGQTEKADHVDLATLM IDFNGEEKAWAMAKWIF------AAINRRDLYEKAKREEP-------------------- ------------------------------------------------------------ ------------------------------------------EW--ENA---NISVLSQE ESLEEEWMG---LLGYLSRISICRKKKDYCKKYRKYVRSKFQCIKDRNARLGES------ -VNLNKRFT----------------RLRLIKEHRSQQEREHELLAIGRTWAKIQDSPVSS VNLELLFD-P--------EDQ--HSEPVHTVVFQGAAGIGKTILARKIMLDWASEKLYQD RFDYLFYIHCREVSL--------GTQRSLGDLIASCCPGPN-----PPIGKIV-SKPSRI LFLMDGFDELQGAF-DEHTE----ALCTNWRKVERGDILLSSLIRKRLLPEASLLITTRP VALEKLQHLLGQARHVEILGFSEARRKE-YFL---KYFSD-----------------E-- -QQAREAFRLIQENEILFTMCFIPLVCWIVCTGLKQQMD----SG----KSLAR-TSKTT TAVYIFFLSSLLQS--QGG----------------SQENHNSATLWGLCSLAADGIWNQK ILFQECDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEDNHGEM--------------------------------- -----------RNTPQACSKLPNRDVKVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLINQERTSYLEKKLS--CKIS-Q-KIRLELLKWIEAKANA ---------------KTLQIEPSQLELFYCLYEMQEEDFVQRAMSHFP-K-IEI--KL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCR---HVESLSLRLL-HNSPKEEEEEEEV ------------------------------------------------------------ ---------RHSHMDRSVLS-DFEVAYSQGLVN-YLTSSICRGIFSVLS-NNWNLTELNL SGN-TLGDP-GMNVLCETLQQPGCNIRRLWLGQCCLSHQCCFNISSVLSNN-QKLVELD- --LSHN-ALGDFG-IRLLCVGLRHLFCNL------------------------------- -KKLW----------LVSCC--LTSASCEDLASVLSTNHS-LTRL--------------- ----------------------------------------------Y--LGENALGDSGV GILCEKVKNPH------------------------------------------------- ------------------------------------------------------------ CNL--QKL--GLVNSGLTSGCCPAL---SSVLSTN-QNLTHLYLQG--NALGDMGVKLLC EGLLHRN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQVL--ELDNCSLTSHCCWDLSTLLT---------- ---------------------------------------------------SNQSLRKLC ------------------------------------------------------------ ---------------------------------------------LGNND-LGDLGVML- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQGCL---LKSLR----LCEMYFNYDTK-RALETLQEEKPEL TIVFEPSR-------------------------------- >T_guttata_ENSTGUP00000004980 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------R---------------------- -----------------------KDLETKVIVVLGKAGMGKSILIQKICQDWSNGEFSQ- -FEFVFWFDCKQLSL-------PEKQYSLKELLLEFFVKPQEGSK-EIFEYML-QNPGKV LLIFDGFKGLHDHE-NFPRC----SASQPEKDLCSIKELLSGLIQKKVLNGCTLLFTARP KDKLYQYMSKVD-KTIEIVGFSPQQREL-YIT---KYFEE-----------------S-- -LYCDSALKLIKECEYLFSHCYSPVMCRFVCFLCEIVLE---------MGENS--LPSTL TEVFLKFFQQKIMF-------------------------MQTDSLATLARVAWCLGEKHQ SAMKSDLIPSK--------------EVKEFAL-------------KH----SDSEEEEFG STFSDFVIQNFLCALHLLLAEELKDKNLTKYLSFLS------------------------ -------------------------------KKKKPY----------------------- --------NWLDLMPRFLAGLMFLQDDPSFCSLSNE-DEKQ-STKKQKTLLKYIRRLQ-- ---------------INTLCPERLLELLCCVYETQNNYLLQHVALRLEPE-LSFLGIV-- ------------------------------------------------------------ -----LTPPDVHV----L-------HSVLKRSR---KEFSLDLQNS-SIDMQGLQALVSL RNVTSFRASLSDTVRLWKSLEQTKDYELL---KASTEKFV----------LDPFKAKTMK DISD-------LSDLA----VQTPGVQEASGCTSYEIP------------AIRNLRKLEF A------------------------------LGPACGLQGLLKLVKILAAF-PSLQHLDL DALSEN-SIGDEG----------------------------------------------- ---------------------------AKSLSEVFPTLTS-LETL--------------- ----------------------------------------------N--LSQNKITDVGA ENLATALPSLS------------------------------------------------- ------------------------------------------------------------ -SL--KTL--SLYNNNICDFGAENL---AKVLPAM-TSLRVLDVQY--NKITGVGAQQLT DSLRKC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PHMKNL--VMWNPTIPYGVLEHLHQ------------- ---------------------------------------------------LDSRISLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_mulatta_ENSMMUP00000009936 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DSMIQRHRKALLSKVGGGSEL------ -AGPWHRLA---S------------LLLVEGLTDLQ-LREHDFTQVEAT--RGGGRPART VALDRLFL-P--------LSR--VSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKD -FSLVLPLTFRDLNT--------HEKLCADRLICSVFPHIG-----EPSLAVA--VPARA LLILDGLDECRTPL-DFSNT----VACMDPKKEIPVDHLITNIIRGNLFPEVSIWITSRP SASGQIPGGLVD-RMTEIRGFNEEEIKV-CLE---QMFPED----------------Q-- -ALLGWALSQVQADRALYLMCTIPAFCRLMGVALGHLWR----SRTGPQDAELW-PPRTL CELYSWYFRMALSR--EGQ-EKGKASPR-----IEQVAHGGRKMVGTLGRLAFHGLLKKK YVFYEQDMKAF--------------GVDLALLQG-A--LCSCFLQRE----ETLAS-SVA YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVS------------------------- ----------------WPRLGFLTHFRSAAQRAMQAE----------------------- -------DGRLDVFLRFLSGLLSPRVNALLAGSLLA-QGEH-Q-AYRTQVAELLQGCLR- ---------------PDAAVCARDINVLHCLHELQHTELVRSVEEAME-S-GAL-ARL-- ------------------------------------------------------------ -----TGPPHRAA----L-------AYLLQVSD---TCA--------------------- -----------QEANLSLSLSQGVLQSLL----PQLLYCR----------K--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------L--SLQWNFIQAGAAQALGQALQ---------- ---------------------------------------------------LNRSLTSLD ------------------------------------------------------------ ---------------------------------------------LQENA-IGDDGACA- --------------------------------------------------------VAHA LKVNTALTALY------------------------------------------------- ------------------------------------------------------------ ---LRGNAIGVSGAKALANALKVNSSLRRL------------------------------ ---NLQGNHIGDSGARMISEAIKTN--------------- >P_pygmaeus_ENSPPYP00000011607 ------------------------------------------------------------ ----------------------------------------------------MLRTAGRD GLCRLSTYLEELEAVELKKFKLYLGT--------ATELGEGKIPWGRMEKAGPLEMAQLL ITHFGPEEAWRLALSTF------ERMNRKDLWERGQREDL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRDTP PGGPSSLGN---QSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGEC------ -VNLSHRYT----------------RLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASP IKIETLFE-P--------DEE--RPEPPCTVVMQGAAGIGKSMLAHKVMLDWADGKLFQG RFDYLFYINCREMNQ-------SATECSMQDLISSCWPEPS-----APLQELI-RVPERL LFIIDGFDELKPSF-HDPQG----PWCLCWEEKPPTELLLNSLIRKKLLPELSLLITTRP TALEKLHRLLEHPRHVEILGFSEAERKE-YFY---KYFHN-----------------A-- -EQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLE----GG----GLLRQ-MSRTT TAVYMLYLLSLMQP--KPG----------------APCLQPPPNQRGLCSLAADGLWNQK ILFEEQDLRKH--------------GLDGADVSA-F--LNMNIFQKD----I---NCERY YSFIHLSFQEFFAAMYYILDEGERGAG--------------------------------- ---------------------PDQDVTRLLTEYAFSE----------------------- -------RSFLALTSRFLFGLLNEETRSHLEKSLC--WKVS-P-HIKMDLLQWIQSKAQS ---------------DGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQ-V-IVV-SNI-- ------------------------------------------------------------ -----ASKMEHMV----S-------SFCLKHCR---SAQVLHLYGT-TYSADGEDRARCS AGVHTLLVQL-PERTVLLDAYSEHLAAAL----CTNPNLI----------ELSLYRN--- ALGS-----RGVKLLCQGLRHPNCKLQNLRLFGMDLNKMTHSRLAALRV-TKPYL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DIGC------------------------------------ >R_norvegicus_ENSRNOP00000004280 ------------------------------------------------------------ ---------------------------------------------------------MMS VRCKLAQYLEDLEDVDLKKFKMHLEDY-------PPEKGCVPIPRGQMEKADHLDLATLM IDFNGEEKAWGMAVWIF------AAINRRDLWEKAKKDQP-------------------- ------------------------------------------------------------ ------------------------------------------EW--NDACTSNLSMVCQE DSLEEEWIG---LLGYLSRISICKKKKDYCKIYRRHVRSRFYSIKDRNARLGES------ -VDLNRRYT----------------QLQLVKEHPSKQEREHELLTIGRT--KMWDRPMSS LKLELLFE-P--------EDE--HLEPVHTVVFQGAAGIGKTILARKIMLDWALGKLFKD KFDYLFFIHCREVSL--------RAPKSLADLIISCWPDPN-----PPVCKIL-CKPSRI LFLMDGFDELQGAF-DEHIE----EVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSN-----------------E-- -LQAREAFRLIQENEILFTMCFIPLVCWIVCTGLKQQME----TG----KSLAQ-TSKTT TAVYVFFLSSLLQS--RGG----------------IEEHLFSAYLPGLCSLAADGIWNQK ILFEECDLRKH--------------GLQKTDVSA-F--LRMNVFQKE----V---DCERF YSFSHMTFQEFFAAMYYLLEEEEEGVT--------------------------------- ----------VRKGPEGCSDLLNRDVKVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QVRLELLKWIEVKAKA ---------------KKLQRQPSQLELFYCLYEMQEEDFVQSAMGHFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIKNCH---RVKTLSLGFL-HNSPKEEEEEKRG S----------------------------------------------------------- ---------QPLDQVQCVFP-DPHVACSSRLVNCCLTSSFCRGLFSSLS-TNQSLTELDL SDN-TLGDP-GMRVLCEALQHPGCNIQRLWLGRCGLTHQCCFNISSVLSSS-QKLVELD- --LSDN-ALGDFG-VRLLCVGLKHLLCNL------------------------------- -QKLW----------LVSCC--LTSACCQDLALVLSSNHS-LTRL--------------- ----------------------------------------------Y--IGENALGDSGV QVLCEKMKDPQ------------------------------------------------- ------------------------------------------------------------ CNL--QKL--GLVNSGLTSLCCSAL---TSVLKTN-QNLTHLYLRS--NALGDMGLKLLC EGLLHPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQML--ELDNCSLTSHSCWDLSTILT---------- ---------------------------------------------------HNQSLRKLN ------------------------------------------------------------ ---------------------------------------------LSNND-LGDLCVVT- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQGCL---LQSLQ----LGEMYLNCETK-RTLEALQEEKPEL TVVFEISW-------------------------------- >T_rubripes_ENSTRUP00000025815 MGSYSIPRVSYGPTQVAPITAVTVNQSLLVPLKIDIDPTVHAVRKQEKEQIMKLNNRFAS FIDKVRHLEQQNKMLETKWKLLQQETATPSEVEPMLKAYVASLQRQL-------DCITSN KSRLDMENSAMHKNVNDNKTKYEQEINKRSYAENEFVMIKKDVDMGYVSKLELEDLLSSL SEEFNFLKAIYDAELFE------LREDMKETSVVVQMDNSRALNMDQVVSEV-------- ----------KLQYEELAARGREEAESWHRIKFDQITAEADQYGNELRSAKNEIAELNRI ISRLQNEIAALKAQHSTLEQQIAEAERHGDAAVIDAKARIKDLGDALQKAKRDMARQLRE YQELMNVKL---ALDIEISTYRKLLEGEEERHWSRQWRQTVHLNLKFSSVQEDYIM--EK NRILTHVLQPKGT------------SSLLSGDLSANVINSCMYISLQTSVAQERDRQVGS VSLDSAVCTT-------------LCAERKNVILVGPEGAGKTTALEKLVLDWAKGERLQS -FIYVFHFNLKELNG-------LQEMLSLETLMLRHSCVPP-----DSMTPLL-QNSEHV LLVFDDLHVFSHCL-DPSLH----TLCADPCQVVSPGCLVASLLHGSLLKGASFVVASRQ SGRLKFLSG----TQMEVLGFLKPQREA-YFN---RAFTD-----------------P-- -TLANKAIAHLEKTLGFYEFCSSPRFCWTVCSLYKSLMN-----------AGEE-LPETV SQLCVGVLVYLIQEVLLTT-------------------ACSRELMLALGKMASHCFLNQH LSCTREELGSF--------------GLEKFLEAA-A--VFLQVDGEQ--------LDTRV FSFPSQLMQEFLIAVSYLWSSASTEGVE-------------------------------- -------------------------------EILEKH----------------------- -------RGHAKLLDSFLSALSEPVQRRPLETVLGE-PNA----DRVADFKRWLKSSSEE A--------------LRGYHKDQHHHYFHLLHQAQSKSLVKEVITITA-R-MGISYAD-- ------------------------------------------------------------ -----LSLQESVA----L-------NYVVECLG---EMEKLNLYLS-------------- -----------------RNLTEEQVEALA----PAMSLSH----------QIMLMDS--- RLSS-----GAVAHLASAL-------------------------------SRGITTELDL SQS-QLGDE-KFKVLCAGLR--DCKLTTLKLQVCRLTELSCDDLASVLSSSTSRLQRLA- --MRHN-QIGDRG-FVKLCTGLRSPHCKL------------------------------- -QELHLKNSFSVLKRIQSCK--LTAASMGALSAALTSGQSELRKV--------------- ----------------------------------------------D--LTLNSIGLPGV ASLCEALQHPS------------------------------------------------- ------------------------------------------------------------ CKL--QRL--VFYDCSLTGESCPHF---KEALMSKHCRLSELDLSV--NELGQEGALLLC HALSRPG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CPVEKL--GLQRCDLNKPVFEELGSLLR---------- --------------------------------------------------SGSSLLKSLS ------------------------------------------------------------ ---------------------------------------------VGLNK-VGDQGVKH- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LWEAVAHPNCLLEELEGG GLSVEMTSLTDACVEDLCAALRATKTLRNLG----LSNNSLTDASAAALVQAAQQCQSLQ EMKYASSSSLRPYKP------------------------- >E_caballus_ENSECAP00000013016 ------------------------------------------------------------ ---------------------------------------------------------MAS VRCKLARYLEDLEDADLKKFKMHLEDY-------PPQKGCTRPPRGQTEKADPVDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLHEKAKLEEP-------------------- ------------------------------------------------------------ ------------------------------------------EW--AHSCCYRSHLICQE ESIEEEWIG---LLEYLSRISICKKKKDYCKKYRKHVRSRFQCIKDRNARLGES------ -VNLNKRYT----------------RLCLLKEHRSQQEREQELLAIGRTSPKTQDCPMSS MNLELLFE-P--------DDQ--HSEPVHTVVFQGAAGIGKTILARKIMLDWASEKLYKN RFDYLFYIHCREVSL--------GTRRSLGDLIVSCCPDPK-----PPIGKIL-SKPSRI LFLMDGFDELQGAF-DEHTE----ALCTDWQKVERGDILLSSLIRKRLLPEASLLITTRP VALEKLQHLLDRPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -QQAHEAFRLIQENEILFTMCFIPLVCWIVCTGLKQQMD----SG----KSLAQ-TSKTT TAVYVFFLSSLLQS--RGE----------------SQKQHLSANVRGLCSLAADGIWNQK ILFEESDLRKH--------------GLQRADASA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEDEEQGSV--------------------------------- -----------RNMPWGRSNLPNRDVSVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWISAKAEV ---------------KKLQTQPSQLELFYCLYEMQEEDFVRRAMGYFP-K-IEI--SL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCR---SVESLSLRLL-YNSPKEEEEEEEE EE---------------------------------------------------------- ------------DGIDFLFS-PSSFLPISRLVNCSLTSSFCQSLFSALS-TNWSLTELNL GDN-TLGDS-GMKVLCDMLQHPGCNIQRLCATHWGLKQQ-KFTFSHLITSL-KALSPNT- --VTFS-GCGETG-TTLHC-GWK---CKM------------------------------- -VQLL----------LVGCC--LTSACCEDLASVLSTSHS-LIRL--------------- ----------------------------------------------Y--LGENALGDSGV GILCEKAKHPR------------------------------------------------- ------------------------------------------------------------ CNL--QVL--GLVNSGLTSGCCPAL---SSVLSAN-HNLKQLYLRG--NALGDTGVKLLC EGLSHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQML--ELDSCSLTSHCCWDLSTLLT---------- ---------------------------------------------------SNQSLRELS ------------------------------------------------------------ ---------------------------------------------LGGND-LGDLGVML- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQGCL---LRSLG----LCEMYFNYETK-CALETLQEEKPEL SVVFEPSW-------------------------------- >T_rubripes_ENSTRUP00000000216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VGKTFSVQKFTLDWAEGLENQD -ISLLVLLSFRELNL------IKDEQHSLLSLLHVFHPTLQ-----KIRAEDL-T-ACKL LLIFDGLDESRLSL-DFKKE----QVISDVTQVSSASMLLVNLIQGNLLPSALIWITSRP AAANQIPPSYVD-RITEIRGFTDTQKEE-YFR---RRFRD-----------------E-- -DLSKRIISHIKASRSLHVMCLIPVFCWITATVLEDMLT---------TEQRGE-LPKTL TDLYSHFLLVQTKR--KKQ-KYGG--HK----GPQELIESDKEVLLKLGRLAFEHLENGN ILFYQNDLEQC--------------GLDVSEVSV-YSGVCTKIFRRE----T-VIFQKSV YCFVHLSIQEFLAAVYIFFKLYD------------------------------------- -----------------PIIPVDDFLSRVMMKSLESP----------------------- -------NGHLDLFVRFLHGLSLESNQRILGGLLNQ-TDNN-P-ETIQKVINNLKEMS-- ---------------SEQISPDRSINIFHCLMEMKDHSVHQEIQELLK-I-YNIQIVL-- AGVMFNWLEFCLKAFCTVKCPKMSIIIFFITTFSCDSLTSGGFHTHLYSLFRFCNCN--- -----LSEISCGS----V-------ASALKSNP--SHLRELDLSYN-QLQDSGVKLLCSG LES------------------------------PNCKLKT-----------LRLNNC--- SLTE-----ISCGSLASALKS-----------------------------NPSHLTELDL SDN-QLQDS-GVKLLCSGLESPNCKLKTLILCDCSLSENSCDSLASALKSNFSHLRELD- --LGLNNQLQDSG-VRLLCSGLESPNCKL------------------------------- -ETLR----------LRDCS--LSETSCGSLASALKSNPSHLREL--------------- ----------------------------------------------D--LKFNQLQDSGV KLLCSGLESPN------------------------------------------------- ------------------------------------------------------------ CKL--ETL--RLWSCSLSEISCGSL---ASALKSNPSHLRELDLGL--NHLQDSGVKLLC SGLESPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLKTL--GLWRCSLSEISCGSLASALK---------- --------------------------------------------------SNPSHLTELD ------------------------------------------------------------ ---------------------------------------------LGDNQ-LQDSGVKL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LCSALESPNCKLETLS----LWSCSISEISCGSLASALKSNPSHL KELDLSC--------------------------------- >T_rubripes_ENSTRUP00000007049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LRQIYT---E------------LYITEGGSGEV-NKQHEVRQIEA--SPRVDARDKC ISCNQLFA-----------EG--QDFQIRRVMTRGVAGVGKTVHVNKFTLDWAEDGEHDH -LDFVFPLSFRELNL------MREKRLSFEELLAVFFPETK-----ESGIFKS-V-FIRI LFILDGLDESRLSL-DFENS----EILADVTQEASVAVLLTNLIRGRLLPLALVWITSRP LASAQIPLEHLH-LVTEVRGFNDPQKDE-YFR---RKIPE-----------------K-- -PLADRVIAHVKSCRSLHIMCHLPIFCWMAATVLRSKLS---------TADGED-SPKTL TQMYIHFLSLYVDN--VNK-RLPDSSES--------KADVLRANLMSLGDLAYRQLEQGN LIFYEKDLVQS--------------GIQVTQASG-FSGVYTQIFSEE----M-ILCREKM FCFIHLSIQEFFAALYVFLKFNNDNFNVLIRKLSP------------------------- -----------SRYFPFRDTSELVLYRGAVDKALQSE----------------------- -------EGHFDIFLRFLLGLSLESNQTLLEHLMIQ-NRTQ-Q-RTRAEIIKHIKEKI-- ---------------RRSSAVDRCLNLFHCLNELNDRSLVDEIQSHLR-S-GHLHQSK-- ------------------------------------------------------------ -----LSSSQWNT----L-------VVVLLASE--EDLGVFVLSQY-ARSEEGSSRSPRF L--------------------------------TVSTCCC----------SDRLNAC--- KLTV-----NCCEKLSNAI-------------------------------STSRLRELDL SNN-PLADA-GVAALSRGLINAN--LETLRLRSCSLTQDSSWPLASTISSGSCKLRLLD- --LSDN-DLRDAG-VQRLCGGLESPDCKL------------------------------- -ETLL----------LSLCG--LTHESCTFLASAL--NSSGLREL--------------- ----------------------------------------------D--LSYNHPGDAGL DLLSTLLHDPQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CSLRQV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_musculus_ENSMUSP00000066841 ------------------------------------------------------------ -------------------------------------------------------MASFF SDFGLMWYLEELNKKEFVKFKEFLKQE-------VLQLGLKQVSWTEVKKASRQDLASLL LKHYEEKPAWDMTFRFF------QKINRKDLIERAKREID-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GCPKLYRAHMKTKMTHDSSRAFTISIQ------ -NFLKEKFT-----------------------------------------------EDDY DCFENLFQ----------SKG--TESKPQVVFLSGGAGVGKTLMLKRLMLAWIESPVFLH KFSYIFYFCCREVKQ--------LKTASLAELISREWPGPS-----APIEEIL-SKPEKL LFIIDSLEGMECDL-FKWES----ELCDNCTEKQPVNVLLSSLLRRKMLPESSLLISATP ESFEKMENRIEYTHVKIIKGLKERNIKM-SFH---RLFQD-----------------R-- -NRAHEAFSLVRENEQLFTVCQVPVLCWMVATCLKEEIE----KG----RDPVS-ICRCT TSLYTTHIFNLFIP--QNA---------------HSPSKKSQDQLQGLCSLAAEGMWTDT FVFGEEALRRN--------------GIMDSDIPI-L--LDIGMLINI----R---ESEKS YIFLHPSVQEVCAAIFYLLKSHVDHPS--------------------------------- --------------------QEVKSIEKLMFAFLKKV----------------------- -------KVQWIFFGSFIFGLLHESEQKKLEAFFG--HQLS-Q-EIKRQLYQCLETISGN ---------------EELQEQIDGMKLFYCLFEMDDDTFLVEAMNCME-Q-INF--VA-- ------------------------------------------------------------ -----KDYSDVIV----A-------AHCLKHCF---TLKKLSFSTQ-NVLSGAQE----- -----------HSYMERLLTAWNHICSVF----IISKDIQ----------ELRMKDT--- NLSE-----SAFSVLYNNLKYHNYTLNVLVANNVFFV--CEKYLFFELI-QNCNLQHLNL SLT-ILSHS-DVKLLCDVLSQAECNIEELVVAACSISSDDCKVFASVLISN-KTLKHLN- --LASN-TL-DKG-IASLCKSLCHPDCIL------------------------------- -EHLV----------LANCS--LNEKCWDYLSEVLRRNKT-LSHL--------------- ----------------------------------------------D--ISSNDLKDEGL KVLCRALTLPD------------------------------------------------- ------------------------------------------------------------ SVL--KSL--SLRHCLITISGCQDL---AEVLRNN-QNLVSLQVSN--NKLEDTGVKLLC DAIKHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CHLEDL--GLEACELTGACCEDLASTFT---------- ---------------------------------------------------QCKTLWAMN ------------------------------------------------------------ ---------------------------------------------LLKNA-LDYNGLVV- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EALKQQTCA---TYVLG----LQITDFDTETQ-AFLVAEQEKNPCL RILSSL---------------------------------- >C_familiaris_ENSCAFP00000010008 ------------------------------------------------------------ --------------------------------------------------MTDGSSSSFF PDFGLLLYLEELNKEELNKFKSFLKNE-------TVEPRSCQIPWVEVKKAKREDLANLM KKYYPGEQAWDVALKIF------GKMNLKDLCERATAEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WTARTMVTE GARTQEEQD------------DQEAVQSDGTEYRIQIKEKFRIMWDKKCLFGGP------ -EDFHPGIA-----------------------------------------------QEDR ELLEHLFD-V--------DVK--TGEQPQTVVLQGAAGVGKTSLVRKAIVDWAEGNLYQQ KFSYVFYLNAREINQ--------LRERSFVQMISKDWPSTE-----GPIERIM-TQPSSL LFIIDSFDELNFAF-EEPDF----VLCEDWTQVHPVSFLMSSLLRKVMLPESFLLVTTRL TACKKLKPLLKNQHSVELLGMSKDARKE-YIY---QFFED-----------------K-- -KRASQVFSSLRSNEMLFSMCKVPLVCWAICTCLEQQIE----MG----GDVSL-TCKTT TALFTRYISSLFPP--VDG---------------NCPSLPNQTQLKSLCHLAAKGVWTMT SVFYREDLRKH--------------GLTKSDVSI-F--LDMNILQKD----T---EYENC YVFTHLHVQEFLAAMFYMLRDNWETRN--------------------------------- -----------------NLFDSFEDLKLLLE-SKSSK----------------------- -------DPHLMQMKCFLFGLLNEDLLKQLETTLK--CRLS-L-EIKGKILQWLEILGNI ---------------KCFPAELEFLELFLCLYETQDEAFISQAMRSFQ-K-VVI--DV-- ------------------------------------------------------------ -----CGKVHLLV----S-------SFCLKHCQ---CLQTIKLSVT-VVFE-KTLNSSPP AEMW-------QKDDGSIIHCWQDLCSVL----HTNEHLR----------ELDLCHS--- NLDE-----LAMKTFYQELRHPNCKLQRLLMRFLSFP-GGCQDIASSLT-HNQNLMHLDL KGS-DIGDD-GVKSLCEALKHPECKLQNLSLESCGLTTLCCLNISKALIRS-QSLRFLN- --LSTN-HLLDDG-VKLLCEALGHPKCHL------------------------------- -ERLS----------LESCG--LTVAGCEDLSLALISNKR-LTHLCLADNILGDDGVKLV NDALKHPQCKLQSLVLRRCHFTSLSSEHLSSALLCNKSLIHL----D--LGSNWIQDDGI KLLCDAFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTSMCCLDL---ASAILNN-SHLQNLDLGH--NDLRDDGVKILC EALRHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--GLEYCGLTSLCCQDLSYTLR---------- ---------------------------------------------------SNQNLIKIN ------------------------------------------------------------ ---------------------------------------------LKQNT-LGYEGMMK- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKSPECK---LKVLG----VCKEAFDEEAQ-KLLEAVRISNPHL IIKRDYND-DDEDGSWWRCP-------------------- >E_caballus_ENSECAP00000006832 ------------------------------------------------------------ --------------------------------------------------------MAGG AELQWPWYLESREKKEPKEFQLRLPD--------AHSRHSPGETVAQVE-ASGPEVASRL VALYGQRQAWDLALLTQ------RRMDLSRVSIQAHREAASIPISSLHASLG-KPNLEFS SAPTSTMVLGHWVPEAP-GLLQDSQRKNLRHLPGTSGHTWKENPPSFPFQDFPYSPV--C ESPSQESPNAPTSTAVLGGWEFPPQSMLACRKQEPPRTAWPLAETSGKHSTVVEGRDRRG HLTGVP-LM---AAEPGSEPQAHTEHPGLWERYQKQWRETPCPTQSRQN----------- -EDLHQKFV---Q------------LLLLHTSD----PGSHESLVRRCCPHGVVEEEGHL IEIGDLFG-P--------GLG--TQRGPHTVVLHGVTGIGKSTLARQVRGAWEEGRLYRD RFQHVFYFNCTELAQ--------SKPVSLAKLMGEDCAAPA-----PP---IR-SQQEKM LFILDGLDEPELVL-EEQR-----PLCEDWSLRQPVPRVLHSLLRKVLLPEASLLVTART PAPQKFILSLEHPHWVEVLGFSESSRKE-YFY---RYFTE-----------------E-- -SQAVQAFSLVESNPALLTLCLVPFVSWMVCTCLKQQME----RG----EELSL-TSQTT TALCLHYLSQALPA------------------------QPLRTQLRCLCSLAAEGVGQGE TLFSLNDLRKH--------------RLDGACIST-L--LKMGLLQKH--------PTSQR YSFIHPFFQGFFAAMSYALGDKEKSD---------------------------------- ------------------HLNSTRRIKKLLE-KCERH----------------------- -------DPFGTPTTPFLFGLLSEQGVRKMEHIFR--CKLS-Q-ERKGDLLQKVRR---- ---------------GHPSLPPYSLQVLRCLYEIQDEDFLTQAMAHFQ-R-TRM--YV-- ------------------------------------------------------------ -----QTDMELLV----F-------TFCVKFCH---HVERLQLNES-GPHR--------- ---------------------------------QAWRPSS----------VVLLSRA--- PVTD-----ACWKVLFSVLQ------------------------------VTGSLKELDL SGN-FLSLS-AVQSLCEALRHPRCHLQTLRLASCGLTAEGCKDLASGLSTS-QTLTELE- --LSCN-VLEDAG-VKHLCQGLRQPSCVL------------------------------- -QRLL----------LVSCG--LTSGFCQDLASVLSAGSR-LTEL--------------- ----------------------------------------------D--LQQNKLGDLGV KLLCEGLRRPT------------------------------------------------- ------------------------------------------------------------ CQL--MLL--WLDQTQLNEEVTEML---RALEKN--AQLLILSRWK--PSVTTPNEGRDG GEMSENR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CSLKRQ--RAESARAQSPKAHSGLLSLE-----LTTAL PVPESSSPQVVQVQPLFLPFPASPGDPHVEPLETKDDFWGPMGPVATEVVDKERSLYRVH LPMAGSYRWPNTGLHFVVRGPVTIEIEFCAWGQFLDRTVPQHSWMVVGPLFDIKAEPGAV AAVYLPHFVVLQGAHVDISLFQVAHFKEEGMLLEKPARVEPCYAVLENPS-FSPVGVLLR MIHAALPFIPVTSTVLLYYHFQPEEVTFHLYLIPNDCTIRKAIDDEEKKFQFVRIHKPPP LTPLYVGSRYTVSGSKK--LEIIPKELELCYRSPGESQLFSEFYIDHFGTGIKLQMRDKK DGTVVWEALVKRGKVETKAVVKPSCLLAVSPSHGLAPASLHFVDRYREQLVARVTSVDPV LDKLHGLVLSEEQYEKVRAEATTPSQMRKLF----SFSKSWDWACKDKFYQALKETHPHL IVELWEK--------------------------------- >X_tropicalis_ENSXETP00000030524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITLGDLLT-P--------VAS--ESQMPRRVLVTGIAGIGKSLAMQRLIHDWAIGMLYRD -VACAVHFAFRELNL-------ARSPLSFLDLVKRNHVHLE-----DVLEELC-LDPRNL LIILDGLDEFQYSI---NDG----KAVKNIREAVPIKDLVYSLISGKLLPGASIVVTSRP RP--SIPIAAFD-RRVVILGFEKEQLRP-CFELLEPHMES-----------------Q-- -LGMYSFHEYIIQNDHLSGMSFIPLYCFIICTAVSSFFQ----CRDSG-YCTER-PPQTI TEVYRCYLCTIMHHHMRGSSNRDGAASEPIVLCSPPILTAMKDVLYQLGKLAYYSLLKNK ILFYPEDIQTY--------------GFHPTELPDSF--LQRIFVQES----G---QQQEV FAFFHLTLQEHLAALYCVMSLTPEAEELTQCLDLW------------------------- -----------CFGVIPEDPVPSKLLSTTLEIQMDNQ----------------------- -------WERLQMFSRFFMGLLCFRIEGKMKGLVDC-L----SHDVLDPLTSWFKGKIR- -----------------YEVNQKLLNLLHCLREFQQETVVQNVASEID-E-VNFFKVT-- ------------------------------------------------------------ -----LNPADCAT----L-------CYVLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >X_tropicalis_ENSXETP00000019187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PQAVLVSGVPGVGKTTLMQKFVYDWANGNLYQR -FAFVFSFKFRDLSN--------KEELSLAQMIVDEYPYLH-----SQLERIL-QNPKHL LFIFDGLDESKDQI-DLKQN----QLCTNPRSMQTVSAIVSSLVRQSLLPGCSVLITSRP TRLATVETSVFN-RISEIMGFFPKEREK-YFL---HFFRD-----------------Y-- -TMGEKAFHYVRENGMLYTFCYIPSYCWIICTVLSMCFR----AQRANSAQTVEFLPKTV TQLYASFISNILANHCQAG-------------------TIDKNFLISIGRMAEYGVNSRI LSFTKEDLDGF--------------SVDASSH------LATSFVMES------GQPPHVS YSFLHLTIQEFMAALGYYLDYSPEG----------------------------------- -------------------------LQKALEEAKSTE----------------------- -------DGRGEIFLRFISGLSDSSTRSLLKPYVGD-LSA----PAAKHVISFLQKSIPN LN-------------SQNPDNRKVLNVFACLTESRNKVLVSSSIGLNR-Q-LDFRDFY-- ------------------------------------------------------------ -----LAPLDCTV----L-------AFILESCR---ETELLDLGAC-FIQTEG------- ------------------------LERIS----AALHTVT-------------------- -------------------DDTHCFISRGNVL------------------IETNLLDIRL ANN-NLRDE-DVQCIYSILTHPQCRIQRLSLRNNGLTELSCLPLALAVSEN-TSLRDLD- --LSKN-KLAGED-FYKLLEVLSAPMCRI------------------------------- -ERLA----------LQEAK--LTPQYAASLLC-LTNNPN-LTHLNISSNFFGDAGYPHI KERDVCHRQCWETELLDLGTCFIQTEGLERISAALHTVRDLSVNHFQ--LTNNNLRDEDV PCLYSILTHLQ------------------------------------------------- ------------------------------------------------------------ CRI--QKF--SLRNNGLTETSCLPM---ALAVSEN-TSLRDLDLSK--NKLAGDDFYQLL EVLSAPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRIERL--AISSNFFGNAGYPHIQKLIL---------- ---------------------------------------------------EHPSLREIN ------------------------------------------------------------ ---------------------------------------------LATNN-LRDEDVEF- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IYSMLTHPQCRIK KLSLRNNGLTEECCGQLAWAIKENTSLRDLD----LSKNKLAGEDFYQLLEVFSDPTCQI EHL------------------------------------- >X_tropicalis_ENSXETP00000009512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---NRLFR-W--------CHR--KRSVPKTVLVSGVPGVGKTTLMQKFVYDWANGNLYQR -FAFVFFFKFRDLNT--------MGKTSLAQMILSEYPYLR-----GDLEQIF-LNPKNL LFIFDGLDESKNQV-DFKSS----HLCNDPQSSGDSSIIVVSLVKQTLLEGCSVLITSRP TRVAEIDVDIFH-RMSQIVGFFPKQREM-YFQ---HFFKN-----------------T-- -LAAEKAFHYVRENGILYTFCYIPAYCWIICTVLEMSFK----TQGSNDPTGFL-FPKTV TQLFVAFVSNILTNHNQDV-------------------SHAKKALTELGLLAEYGLSNQA LVFEEEDVQPY--------------ITNTNSH------MVSSFIVES------GQPPRLS YSFFHLTVQEFLAALLHYLDCSSEK----------------------------------- -------------------------LKETLTNTRSFE----------------------- -------DGRREIFLRFISGLSDNSTRSLLKPFVGT-LSA----QASKDVISFLQESVTQ AWNPD----------RQDADKRKILNVFACLAESRNKGLVSSSIGSNQ-E-FDFVDFY-- ------------------------------------------------------------ -----LAPLDCTV----L-------AFILESCG---ETELLDLSSC-FIQSEG------- ------------------------LERLA----PALHNIA----------VLN------- -----------------------------------------------------------L TNN-NLRDE-DMRYIHSILTNPQCRIRTLSLMNNGLTEESCLTLANAINEN-KSLRELD- --LSKN-KLAGKNSFLQLLAVLSEPTCRI------------------------------- -ECLE----------LQEIK--LTPEYAAFLLS-LTNNPN-LTDL--------------- ----------------------------------------------N--IS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_musculus_ENSMUSP00000065508 ------------------------------------------------------------ -------------------------------------------------------MASFI SDFGLMWYLKELNKKEFIKFKEFLIQE-------ILKLKLKQISWTEVKKASREDLANLL LKCYEENQAWDMTFNIL------QKINRKDLTERATEEIA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------DSSPLGLTDSGNPKLYRDHLKKKLTHDCSKKFNVRIQ------ -DFIKEIFI-----------------------------------------------QNDC DTFENLLI----------SKG--TEKKPHMVFLQGMAGIGKTMMLKNLMLAWSKGLVFQN KFSYTFYFCCRDVKQ--------LKTASLAELISREWPSPS-----APIEEIL-SQPEKL LFIIDSLEGMECDL-TKQES----ELCDNCMEKQPVSILLSSLLTRKMLPESSFLLSTTP ETFEKMEDRILCTDVKTATAFDERSIKI-YFH---RLFQD-----------------K-- -IRAQEAFSLVRENEQLFTICQVPLLCWMVATCLKEEIE----KG----GDPVS-VCRHI TSLYTTHILNLFIP--QSA---------------QYPSKKSQDQLQGLCSLAAEGMWTDT FVFGEEALRRN--------------GILDSDIPT-L--LDIGMLGKI----R---EFENY YIFLHPSVQEVCAAIFYLLKSHVDHPS--------------------------------- --------------------QDVKSIETVLFMFLKKV----------------------- -------KTQWIFLGCFIFGLLQKSEQEKLVVFFG--RRLS-Q-KIQHKLYQCLETISGN ---------------AELQEQIDGMKLFCCLSEIEDEAFLVKVMNCMQ-Q-INF--VA-- ------------------------------------------------------------ -----KNYSDLIL----A-------AYCLKHCS---TLKKLSFSTQ-NVLNEKGN----- -----------QRCMKKLIICWNDMCSVF----VRSKDIQ----------VLQIKDT--- SFNE-----PAIRILYEYLKYPSFTLNKLVANNVHFF--GDNHAFFELI-QNCSLQYLDL GCS-FLTHS-EVKLLCDVLNQAECNIEKLVVSHCKLSPDDCKIFGSVLMSS-KTLKVLN- --LAYN-NL-NQG-ISLLCKALCHPDCIL------------------------------- -EYLV----------LANCS--LSEQCWDYLSEVLRQNKT-LSHL--------------- ----------------------------------------------D--ISSNDLKDKGL KILCRALTLPY------------------------------------------------- ------------------------------------------------------------ CAL--KSL--YLNNCQITARGCQDL---AKVLRNN-QNLKCLHISN--NKLKDAGLMLLC KAIKHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CHLEDL--RLEACEITGASNEDLRYAFM---------- ---------------------------------------------------QCETLQMIN ------------------------------------------------------------ ---------------------------------------------LMGNA-LEMLDY--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >T_guttata_ENSTGUP00000005258 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KVIFLFGKPGIGKTRLMHRICQKWAEGVLPQ- -FLFTFLFEFRQLNL-------LKGKLTLQELLFDMFLQPEDSPH-AVFQALL-ENAQQT LIIFDGLDEFAANM----------DIGPALTSPMSISQLFADLCHGNLLPGCTVLVTSRP KRLPNFLLYTVG-VLAEIGGFDHEKVEE-YVS---HYFCQ-----------------H-- -SFRERAIAHVKNNTKLLSMCFIPALCNIVCICLEYLFL----KQ----QMSVE-LPQTM TQFYIKMFLIFLSN------------------------EETVQAILGLFDLALRGLEEKK LVFYVSDIPED--------------VKEFASLHG-L--LTVFEVKTS------GTCPEVG YAFVHLSLQEFFAALCLMVSRRVDKNYLKKKFF--------------------------- -------------------------LKSKWTLKNETK----------------------- -------TEFVESFHIFLSGLSSRECRTFLMLLAEQ-DEAW-VQEKQDVILQSLRKLA-- ---------------ATHLSGPKVLELCHCTFETQNLEVAQHIGSLLNFK-YEFKNFR-- ------------------------------------------------------------ -----LTTLDMSA----L-------VFVINSGQ---DLICLDFAGC-LVDTD-------- ------------------------CLEVL----AGCKNVE----------HLSFRSR--- RCGD-----DFAAALSKGLQ------------------------------GMRNLKKLEL TGG-TITAE-GMTNLVQAASQCP-HLEEI------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >O_cuniculus_ENSOCUP00000008333 ------------------------------------------------------------ ----------------------------------------------------MLPAKLGG GLCRLSAYLEELEAVDLKKFKLYLGT--------AAELGEDRIPWGRMETAGPLDVAQLL VAHCGPERAWQLALRVF------ERMHRRDLWERGQREHP-------------------- ------------------------------------------------------------ -------------------------------------------------------AGXXX XXXXXXXXX---XXXXXXXXXXXXXXXXPREAYRDYVRRRFRLMEDRNARLGEC------ -VNLSHRYT----------------RLLLVKEHSSPLRAQQMLLDMGRGHARSGGSQASP IRVEMLFE-P--------DEE--RPEPPRTVVLQGAAGMGKSMLAHKVMLDWADGRLFQH RFDFLFYVNCREMNQ-------AAPEQSAQDLLASCWPEAG-----APLRELA-HLRGRL LLILDGFDELKPSF-HEARG----PWCRCWEEKRPTELVLSSLIQKKLLPELCLLITTRP SALEKLQRLLEHPRHVEILGFPEAERKE-YFL---RYFQD-----------------A-- -AQAAQAFGFVRDSEPLFTMCFVPMVCWVLCTCLKQQLE----GG----GLLGQ-TSRTT TAVYTLYLLSLLQP--KPG----------------TPAPRPPPNQRGLCSLAADGLWAQK VLFEERDLQRH--------------GLDGADVSA-F--LNMNIFQRD----I---NCEKF YSFIHLSFQEFFAAMHYALEGTEGGAG--------------------------------- ---------------------PDQNLARLLAEYGFSE----------------------- -------RSFLALTVHFLFGLLSEETRSYLERTLC--WKVS-P-QVKEALLRAIQSKARS ---------------EGSTLQAGSLEVFSCLYEIQEEEFVQQALSHFQ-V-VVV-GHI-- ------------------------------------------------------------ -----ATKMEHMV----S-------AFCAKHCR---SAVVLHLHGA-AYGMDADDGT-GW TGAQTPLAEP-AERSILPDAYSQPLAAAL----CCCPDLV----------ELALYRN--- ALGS-----RGLRLLCQGLRHPGCRLQNLRLKRCRIPSSACGDLATALT-ANRHLLRLDL SGN-SLGLP-GMELLCEGLRQPRCRLQMVQLRKCLLDEGACRELASVLCTN-PHLAELD- --LTGN-ALEDAG-VGRMCQGLRHPGCRL------------------------------- -RT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >D_rerio_ENSDARP00000094455 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KNANKCLEKELVVLSDSERKKAK LDTSQLFHNL-------------DSKSKQSFAFLGKSGVGKTTFIQRLCLDWSNSGLPQ- -FQFVFLMNCKILDF-------KQSNYSLKTLLFDFSTSPHCEDSNAAFKHIL-SCPDEV LIIFDSFDHIKDLE-GLLQS----PAKSHTDTKYTIKQLFSGLFQKEILSGCTLLIATRP KDVLNQVLRKMD-CLLEIWGFSPEDIEL-YTS---KYFEE-----------------A-- -SLRESALQKIKNQGYMFSLCSNPLLCWATCFLLKH-------------QDGED-LPSTL TDLYQRVTSKHLEL--ASI---------------GNSTKKKQLDTPQLCKMAWEGFKNHD T--HVNLVKST--------------ELLDCALKSGI--LI-----------PYKTSEQEE NHFADLFTQNFLSALHLVQSKQVNDKTVVANTMVQH------------------------ -------------------------------KKRKVQ----------------------- -------GESQDVLQRFITGLIFQKTASGLSIIDSS-VDLK---AKRKAVEAHLESMK-- ---------------PKDLVPARLLELFHCVYETCSVKFAQGLVKNLPDD-LSFCGTQ-- ------------------------------------------------------------ -----LSPSDVYV----I-------CHILQHASAMKRTFTINLQDT-CIPIRGLKELVGL KCIASFWAHAEDTIDLWEDLHQSNDELNL---KSAIEKFT----------LNPLKATQGY HIES-------LPVLVQIHREK----KLPTRYSINCVP------------ALRHLQKLEF G------------------------------LGVQNGPELFPKVIEVLPSL-QSLLCLD- --LDKN-HIGDSG----------------------------------------------- ---------------------------AEKLSGVLHFLEC-LKLL--------------- ----------------------------------------------I--LSQNLIGDAGV GKLAQALASVP------------------------------------------------- ------------------------------------------------------------ -SL--QTL--RLYGNAIADSGAEHL---ALALPDM-KSLQDLDVKF--NKFTDIGATKLS AALKN-C----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PGMKSL--ELWNNCIPYGVFEHLRL------------- ---------------------------------------------------QDSRIKSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_musculus_ENSMUSP00000041908 ------------------------------------------------------------ -------------------------------------------------------MASFI SDFGLIWYLRELNKKEFMKFKDFLIQE-------ILELKLKQVSSTKVKKASREDLANLL LKC-GENQAWDMTFRIL------QKINRKDLTERATGAIV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GNPNLYRDHLKKKLTHDCPKKFNVRIQ------ -DFIKETFI-----------------------------------------------QNDY DAFENLLI----------SKG--TERKPHMVFLKGMAGVGKTLMLKNLMLAWSKGLVFQN KFSYAFYFCCQDVKQ--------LKTASLAELISREWPSPS-----APIEEIL-SQPEKL LFIIDSLEGMEWDL-TKQES----ELCDDCMEKQPVSTLLSSLLRRKMLPESSLLLSTTP ETFEKMEDRIQCTDVKTATAFDERSMKI-YFH---RLFQD-----------------R-- -KRAQEAFSLVRENKQLFTICQVPLLCWMVATCLKEEIE----KG----GDPVS-LCRRT TSLYTTHIFSLFIP--QSA---------------QYPSKKSQDQLQGLCSLAAEGMWTDT FVFGKEALRRN--------------GIFDSDIPT-L--LDIGMLGKI----R---EFENS YIFLHPSVQEVCAAIFYMLKRHVEHPS--------------------------------- --------------------QDVKNIETVLFMFLKKV----------------------- -------KTQWIFLGCFIFGLLQKSEQEKLGVFFG--HRLS-K-NIHHKLYQCLETLSGN ---------------AELQEQIDGMRLFSCLFEMEDEAFLVKAMNCMQ-Q-INF--VA-- ------------------------------------------------------------ -----KNYSDFIV----A-------AYCLKHCS---TLKKLSFSTE-NVLNEGD------ -----------QSYMEELLICWNNMCSVF----VRSKDIQ----------ELRIKDT--- NFNE-----PAIRVLYESLKYPSFTLNKLVANNVSF---GDNHVLFELI-QNSSLQYLDL SCS-FLSHN-EVKLLCDILNQAECNIEKLMIAHCKLSPDDCKIFGSILMSS-KSLKVLN- --LASN-NL-NQG-ISSLCKALCHPHCTL------------------------------- -EYLV----------LSNCS--LSEQCWDYLSEVLRQNKT-LSHL--------------- ----------------------------------------------D--ISSNDLKDEGL KILCRSLILPY------------------------------------------------- ------------------------------------------------------------ CVL--ESL--CLSCCGITERGCQDL---AEVLKNN-QNLKYLHVSY--NKLKDTGVMLLC DAIKHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CHLKDL--QLEACEITDASNEELCYAFM---------- ---------------------------------------------------QCETLQTLN ------------------------------------------------------------ ---------------------------------------------LMGNA-FEVSRMVF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------FPRKSELMLFIFLHLSR----LWITDFDNEFQ-AFLLSVKKKNHFL TIRGSVEADGEKKGGDSDARTMGELSNEI----------- >H_sapiens_ENSP00000329568 ------------------------------------------------------------ -------------------------------------------------------MTSPQ LEWTLQTLLEQLNEDELKSFKSLLWAF-------PLEDVLQKTPWSEVEEADGKKLAEIL VNTSSENWIRNATVNIL------EEMNLTELCKMAKAEMM-------------------- ------------------------------------------------------------ ---------------------------------------------------EDGQVQEID NPELGDAEE-----------DSELAKPGEKEGWRNSM-EKQSLVWKNTFWQGDI------ -DNFHDDVT------------------------------------------------LRN QRFIPFLN-P--------RTP--RKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPT -LRYAFYLSCKELSR--------MGPCSFAELISKDWPELQ-----DDIPSIL-AQAQRI LFVVDGLDELKVPP-GALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP RALRDLQLLAQQPIYVRVEGFLEEDRRA-YFL---RHFGD-----------------E-- -DQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQME----KG----EDPVP-TCLTR TGLFLRFLCSRFPQ-----------------------GAQLRGALRTLSLLAAQGLWAQM SVFHREDLERL--------------GVQESDLRL-F--LDGDILRQD----R---VSKGC YSFIHLSFQQFLTALFYALEKEEGEDR--------------------------------- ----------------DGHAWDIGDVQKLLSGEERLK----------------------- -------NPDLIQVGHFLFGLANEKRAKELEATFG--CRMS-P-DIKQELLQCKAHLHA- ---------------NKPLSVTDLKEVLGCLYESQEEELAKVVVAPFK-E-ISI--HL-- ------------------------------------------------------------ -----TNTSEVMH----C-------SFSLKHCQ---DLQKLSLQVA-KGVFLENYMDFEL DIEFE----------------------------SSNSNLK----------FLEVKQS--- FLSD-----SSVRILCDHVTRSTCHLQKVEIKNVTPD-TAYRDFCLAFI-GKKTLTHLTL AGH-IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKAN-QSLKHLR- --LSAN-VLLDEG-AMLLYKTMTRPKHFL------------------------------- -QMLS----------LENCR--LTEASCKDLAAVLVVSKK-LTHL--------------- ----------------------------------------------C--LAKNPIGDTGV KFLCEGLSYPD------------------------------------------------- ------------------------------------------------------------ CKL--QTL--VLQQCSITKLGCRYL---SEALQEA-CSLTNLDLSI--NQIA-RGLWILC QALENPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLKHL--RLWSCSLMPFYCQHLGSALL---------- ---------------------------------------------------SNQKLETLD ------------------------------------------------------------ ---------------------------------------------LGQNH-LWKSGIIK- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GVLRQRTGS---LKILR----LKTYETNLEIK-KLLEEVKEKNPKL TIDCNASGATAPPCCDFFC--------------------- >O_latipes_ENSORLP00000003302 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MRVVLTSGVAGAGKTFSVQKFTLDWAEGLENQD -ISAVVPLSFREMNL------IRDEQHSLLTLIQRFHPTFQ-----KIPADQL-S-VWKI LFIFDGLDESRLSL-DFNNS----QVVSDVTQKSSINVLLTNLIQGRLLPSALVWITSRP AAANQIPPSCVD-RLTEVRGFNDAQKEE-YFR---KRFTD-----------------E-- -ELSSRIISHIKGSMSLYIMCEVPVFCWITAVVMENLLT---------TEQRGE-LPTTL TDMYSHFLMVQTKR--KKN-KYQQEHEE----NPQELTEADMEVLLKLGRLSFEHLEKGN IMFYQEDLEQC--------------GLDVTEASL-YSGVCTEIFRRE----C-EIFQKPV YSFVHLSVQEFLAAVYMIHCYNKKDCM--------------------------------- -----------------ENPSLDEFLNRVMEKSLQSQ----------------------- -------TGRLDLLVRFLHGLSVESNQRLLGGLLGQ-TEKN-P-ETIQRAINNLKEIN-- ---------------SKGVSPDRSINIYHCLMEMKDLSVYQEIQEFLKIALRVKSLAH-- -------LEPPAFSSQHLGTPSTPFVTVVSSAFLMMMLLE-------------------- -----SGEVQCFHCLRFV-------ASALKSNP--SHLTVLDLSNN-SLQDS-MKVLCSG LES------------------------------PNCRVQT---------LSFRLKEC--- SLSE-----INCEALGSALKE-----------------------------NPSNLTELDL SDNYSLHDS-GFLLLCGFLESPDCRLQTLRLMGCSLSGISCEELGSALKKYPSNLKELD- --LSWNWKLQDSG-FLHLCGFLESPDCRL------------------------------- -QILR----------LKRGS--LSTISCKALGAALKKNPSNLTEL--------------- ----------------------------------------------N--LSRNSLKDSGF LHLCGFLESPD------------------------------------------------- ------------------------------------------------------------ CRL--QTL--RLKRCSLSTISCKAL---GSALKKNPSHLTELDLTE--NNLQDSGFLHLC GFLESPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQIL--RLMGCSLSEVSCKVLASALK---------- --------------------------------------------------KNPSNLTELD ------------------------------------------------------------ ---------------------------------------------LNGNQNLQDSGVLH- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LCGFLESPDCRLQTLGSDSMLWLCRLSKTSCANLVSALKSNPSHL TELDLSFNNLQSSDVQQLQDLMKSPKSKLQTL-------- >P_pygmaeus_ENSPPYP00000011694 ------------------------------------------------------------ ------------------------------------------------MNFSVITCPNGG TNQGLLPYLIALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL DEYFPKGQAWKVILGIF------QTMNLTSLCEKVRTKMR-------------------- ------------------------------------------------------------ -------------------ENVQTQELQDPTQEDVEMLEAAAGNMQTQGCQDPNQEELEE LEEETGNVQAQRCQDPNQEEPEMLEEADHRRKYREKMKAELLETWDNINWPKDH------ ------VYI-------------------------------------------RNTSKDEH EELQRLLD----------PNR--TRAQAQTIVLVGKAGVGKTTLAMQAMLHWANGVLFQQ RFSYVFYLNCHKIRY--------MKETTFAELISLDWPDFD-----APIEEFM-SQPEKL LFIIDGFEEIIISE-SRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKT WFVRDLKASLVNPCFVQITGFTGDDLRV-YFM---RNFDD-----------------L-- -SEVEKILQQIRKNETLFDSCSVPMVCWTVCSCLKQPKV----RY----YDLQS-ITQTT TSVYAYFFSNLFSR--AEV---------------DLADDSWPGQWRALCSLAIEGLWSMN FTFNKEDTEIE--------------GLEVPFIDS-L--YEFNILQKI----N---DCGGC TTFTHLSFQEFFAAMFFVLEEPREFPP--------------------------------- ------------------HSTKPQEMKMLLQHVLLDK----------------------- -------EAYWTPVVLFFFGLLNKNIARELEDTLH--CKIS-P-RVMEELLKWGEELGKA ---------------ESASLQFHILRLFHCLHESQEEDFTKKMLGHIF-E-VDL--NI-- ------------------------------------------------------------ -----LEDEELQA----S-------SFCLKHCK---RLNKLRLSVS-SHILERDLEILE- -----------TSKFDSRMHAWNSICSTL----VTNENLH----------ELDLSNS--- KLHG-----SSVKGLCLALKNPRCKVQKLTCKSVTPE-WVLQDLIIVLQ-GNSKLTHLNF SSN-KLGMT--VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSI-QHVTRLC- --LGFN-RLQDDG-IKLLCAALTHPKCAL------------------------------- -ERLE----------LWFCQ--LGAPACEHLSDALLQNRS-LMHL--------------- ----------------------------------------------N--LSKNSLRDEGV KFLCEALGHPD------------------------------------------------- ------------------------------------------------------------ CNL--QSL--NLSGCSFTREGCREL---ANALRHN-HNVKILDLGE--NDLQDDGVKLLC EALKPSH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALHTL--GLAKCNLTTACCQHLFSVLS---------- ---------------------------------------------------SSKSLVNLN ------------------------------------------------------------ ---------------------------------------------LLGNE-LDPDGVKM- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KALRKSTCR---LQKLG----------------------------- ---------------------------------------- >E_caballus_ENSECAP00000012371 ------------------------------------------------------------ -----------------------------------------MDPDSL-------QLGTKS LWSWLVRLLSQAPEWMNAKVKFFLPNMDLGSRSEALDPSQRIIQQLRELYAQGPAPWQTF IHCVCMELEVPLELEVP------LLSTWGHGDGFPSPLEA-------------------- ------------------------------------------------------------ ------------------------------------------------GEDCGPESQLQH GIKRPHQSC---GSSP-RPKQSRKQQLELAKRYLKLLRSSAQQRYGGRILGPGQP----- -LVFPQAYV---P------------PVLQWSRATAPFSTQEGALMGDPKAED-----GTD VSILDLLNTR-------------ADKGPRVRVLLGKAGMGKTTLAHWLCQKWADGQLDR- -FQALFLFEFRQLNL-------ITSVLTLPQLLFDLYLSPEEGPD-AVFEYLE-DNANGV LLIFDGLDEALQPY---------------PEALGPALTLFSDLCRGTLLPGCWVMATSRP GKLPACVPTEA--ATVHMWGFDRPRVEE-FVG---RFFSD-----------------L-- -PSQKAALAELRANRRLRSLCAVPALCRVTCVCLHHLLP------GSSPGQSAA-LLPTM TQTYVQMMLALRPR-----------------------GYLPANSLMGLCEVALSGLETGK VIFSARDIPPA--------------TLAFGAAHG-L--LISFCICIS------PGRQETG YAFPYLSLQEFFAALHLMASPEVDQDALARHVT--------------------------- -------------------------LNSRWVLRTKAR----------------------- -------LGLSDHLPAFLSGLASCACRHFLSQLAQR-DEVW-VSAKQAAVAQALRKLA-- ---------------TRRLTGPKVVELCHCVSETQESELAGLVAQSLPYQ-LQFHNFP-- ------------------------------------------------------------ -----LTHADLAA----V-------TNILGHRD---APVHLNFEGC-PLEPS-------- ------------------------CPEAL----ASCGQVE----------SLSFKSR--- KCGD-----AFAEALSRSLP------------------------------TMGSLKKLGL AGS-KITAR-GISHVVQALSLCP-QLEEVSFQDNQLKDQEVLSIVKILPRL-PHLRKLD- --LSRN-HVSDWTLLHLTEVAVTCPTVRMLQVTKADLIFLLSPPAETAAELPGAPDLQES ASSRKEAQSRSLTLRLQECQ--LGVHEVEMLLAQLRKGPH-LDEV--------------- ----------------------------------------------D--LSGNQLEDEGC RLMAEAAPQLHITRKLDLSDNGLSMAGLYRVLGAASTCRTLAELHISLLHKTVVLTFAPE PEEQAGM----QRRAVFPDS--HVPQTPSELPLRSQRIRLAHCGLQAKHLELLCKALEGS HHL--GHL--DLSSNALGDEGAAQL---AQLLPGL-GPLQSLNLSE--NGLSPDAGFSLA LCFSTVQWVLHLDITGESQRIVLGG-----AGRGRDLSAAGSVPELPAGAEFLGSGQRCV PRSFCLSECQLEPLSLTRLCDTLEKCPGPLEVTLSCKGLSDQSLETLLHRLPRLPQLSRL RLSQTALSPRSPLILADVFSLCPRVQKVDLQSLCHTTLHFRSSEEQEGGCCGRQPGCPRT LGHIGELCWLMGTKIKDPLEINLSANQLGDAGLQCLLEHLPRVPISGSLDLSHNRLSQES ALCLVETLPSCPRIREASVSAGQQGASGIHFSPPEEAGEDPEVTSCHFRPEHVPRLASGL SQAPQLAELTLTQCCLGLEQLTVLLSLVRWPRGLLSLR----VEEPWVGRAGVLTLPEVC AQASGNVTKISISETQQQLCVQLEFPRQ-ENPGAVPLRLAHCDLGTHRSLLVRQLMETCA RLRQLSLSQVNLC---DASSLLLENLLLSVSELKTFRLISSRVSSEGLAHLTSGLSHCPH LEELELSNTQFGEEDTKVLMGALEGKRRLKRLNLSHLPLGGSSLAVLTQGLSRMILLQSL RLSSNGISDIGCCHLSKALRAVTSLEEL--GLSHNQIGDTGAQHLAAVLP---------- ---------------------------------------------------GLPELRKID ------------------------------------------------------------ ---------------------------------------------LSANG-IGPAGGMR- ------------------------------------------------------------ LVESLALCTHLEELMLGCNALGDPTALRLAQALP--PHLRVLHLPSSRLGPEGALSLARA LDRCPQVEVISLAENSLAGGVPHFCQGLPLLRQIDLVSCEIDDQTAKPLAAGFMLCPALE EILLSWNLLGDEAAAELARVLPRMGRLKRVD----LEKNRITACGAWLLAEGLAQGSGIQ VIRLWNNLIPTDMAQRLQSQEPRLDFAFFHNQPPA-PRGT >M_musculus_ENSMUSP00000046503 ------------------------------------------------------------ -------------------------------------------------------MASFF SDFGLMWYLEELNKKEFMKFKEFLKQE-------ILQLRLKQISWTEVKKASREDLANLL LKHYEEKKAWDMTFKIF------QKMNRKDLMERAGREIA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GHSKLYQAHLKKKLTHDYARKFNIKVQ------ -DFSKQKFT-----------------------------------------------QDDY DRFENFLI----------SKV--TAKKPHMVFLQGAAGIGKSLMLTKLMLAWSEGMVFQN KFSYIFYFCCQDVKK--------MKRASLAELISKEWPKTS-----APIEDIL-SQPEKL LFVIDNLEVMECDM-SERES----ELCDTCTEKQPVRILLSSLLRRKMLPKSSFLISATP ETFEKMEGRVECTNVKIVTGFNESNIKM-YFR---SLFQD-----------------K-- -TKTQEIFSLVKENQQLFTVCQVPVLCWMVATCLKKEIE----KG----RDLVS-VCRRT TSLYTTHIFNLFIP--QSA---------------QYPSKESQAQLQSLCSLAAEGMWTDT FVFGEEALRRN--------------GIMDSDIPT-L--LDVRILEKS----K---KSEKS YIFLHPSIQEVCAAIFYLLKSHMDHPS--------------------------------- --------------------QDVKSIEALIFTFLKKV----------------------- -------KVQWIFFGSFIFGLLHESEQKKLEAFFG--HQLS-Q-EIKRQLYQCLETISGN ---------------EELQEQVDGMKLFYCLFEMDDEAFLAQAMNCME-Q-INF--VA-- ------------------------------------------------------------ -----KDYSDVIV----A-------AHCLQHCS---TLKKLSLSTQ-NVLSEGQE----- -----------HSYTEKLLMCWHHMCSVL----ISSKDIY----------ILQVKNT--- NLNE-----TASLVLYSHLMYPSCTLKALVVNNVTFL--CDNRLFFELI-QNQCLQHLDL NLT-FLSHG-DVKLLCDVLSQEECNIEKLMVAACNLSPDDCKVFASVLISS-KMLKHLN- --LSSN-NL-DKG-ISSLSKALCHPDCVL------------------------------- -KNLV----------LVNCS--LSEQCWDYLSEVLRRNKT-LNHL--------------- ----------------------------------------------D--ISSNDLKDEGL KVLCGALSLPD------------------------------------------------- ------------------------------------------------------------ SVL--KSL--SVRYCLITTSGCQDL---AEVLRKN-QNLRNLQVSN--NKIEDAGVKLLC DAIKHPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CHLENI--GLEACALTGACCEDLASAFT---------- ---------------------------------------------------HCKTLWGIN ------------------------------------------------------------ ---------------------------------------------LQENA-LDHSGLIV- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EALKQQQCT---LHVLG----LRITDFDKETQ-ELLMAEEEKNPHL SILSSV---------------------------------- >P_troglodytes_ENSPTRP00000039083 ------------------------------------------------------------ ------------------------------------------------------MVSSAQ MGFNLQALLEQLSQDELSKFKYLITTF-------SLAHELQKIPHKEVDKADGKQLVEIL TSHCDSYWVEMASLQVF------EKMHRMDLSERAKDEVR-------------------- ------------------------------------------------------------ -------------------------EAALKSFNKRKPLSLGITRKERPPLDVDEMLERLK TEALAFPETK-GNVICLGKDVFKGKKPDKDNRCRYILKTKFREMWK--SWPGDS------ -KEVQ-VMA------------------------------------------------ERY KMLIPFSN-P--------RVL--PGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHK -FKYAFYLSCRELSR--------LGPCSFAELVFRDWPELQ-----DDIPHIL-AQARKI LFVIDGFDELGAAP-GALIE----DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRP RALRDLRILAEEPIYVRVEGFLEEDRRA-YFL---RHFGD-----------------E-- -DRAMRAFELMRSNADLFQRGSAPAVCWIVCTTLKLQME----KG----EDPVP-TCLTR TGLFLRFLCSRFPQ-----------------------GAQLRGALRTLSLLAAQGLWAQT SVLHREDLERL--------------GVQESDLRL-F--LDGDILRQD----R---VSKGC YSFIHLSFQQFLTALFYALEKEEEEDR--------------------------------- ----------------DGHTSDIGDVQKLLSGVERLR----------------------- -------NPDLIQAGYYYFGLANEKRAKELEATFG--CRMS-P-DIKQELLRCDISCK-- ---------------GGHSTVTDLQELLGCLYESQEEELVKEVMAQFK-E-ISL--HL-- ------------------------------------------------------------ ------NAVDVVP----S-------SFCVKHCR---NLQKMSLQVI-KENLPENVTASES DAEVER-----SQDDQHMLPFWTDLCSIF----GSNKDLM----------GLAINDS--- FLSA-----SLVRILCEQIASDTCHLQRVVFKNISPA-DAHRNLCLALR-GHKTVTYLTL QGN-DQDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVN-QSLTCVN- --LSDN-ELLDEG-AKLLYTTLRHPKCFL------------------------------- -QRLS----------LENCH--LTEANCKDLAAVLVVSRE-LTHL--------------- ----------------------------------------------C--LAKNPIGNTGV KFLCEGLRYPE------------------------------------------------- ------------------------------------------------------------ CKL--QTL--VLWNCDITSDGCCDL---AKLLQEK-SSLSCLDLGL--NHIGVKGMKFLC EALRKPL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLRCL--WLWGCSIPPFSCEDLCSALS---------- ---------------------------------------------------CNQSLVTLD ------------------------------------------------------------ ---------------------------------------------LGQNP-LGSSGVKM- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ETLTCSSGT---LRTLR----LKIDDFNDELN-KLLEEIEEKNPQL IIDTEKHHPWEERPSSHDFMI------------------- >P_pygmaeus_ENSPPYP00000008024 M---------------------------------------RC------------------ ------------------LAPRPA--GSYLSEPQGSSQCAIMEVGPL-EGGYLELLNSDA DPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDIEGDEETREAYANIAELD QYVF-DSQLEGLSKDIF-KHIGPDEVIGESMEMPAEVGQKSQK---RPFPEELPADLKHW KPAEPPTVVTGSLLVGPVSNSSTLPCLPLSALFNQEPASGQTHLEKTDQIPIPSSSSSLS CLNLPEGPIQFVPTISTLPHGLWQISGAGTEVSSIFIYHGE-VPQASQVPPPSGLTVHGL PTSPDRPGS---TSPFAPSATDLPSMPEPALTSRANMTEHKTSIIQCQAAGEVSNKLPKW PEPVEQFYRSLQDTYGAQPAGRDGILVEVDLVRARLERSSSKSLERELATPDWAERQLAQ GGLAEVLL-A--------DKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ- -YDFVFSVPCHCLNR-------PGDAYGLQDLLFSLGPQPLVAAD-EVFSHIL-KRPDRV LLILDAFEELEAQD-GFLHS----TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARP RGRLVQSLSKAD-ALFELSGFSMEQAQA-YVM---RYFES-----------------SGM TEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLE---------LGEDAK-LPSTL TGLYVGLLGRA-------------------------ALNSPPGALAELAKLAWELGRRHQ STLQEDQFPSA--------------DVRTWAMAKGL--VQ-----------HPPGASESE LAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTP------------------------ -------------------------------RKKRPY----------------------- -------DNWLEGVPRFLAGLIFQPRARCLGALVGP-SATALADRKQKVLARYLKRLQ-- ---------------PGTLRARQLLELLHCAHEAEEAGIWQHVVQELPAR-LSFLGTR-- ------------------------------------------------------------ -----LTPPDAHV----L-------GKALEAAG---RDFSLDLRST-GICPSGLGSLVGL SCVTRFRAALSDTVVLWESLRQHGETKLL---QAAEEKFT----------IEPFKAKSLK DVED-------LGKLVQTQR-----TRSSSEDTAGELP------------AVRDLKKLEF A------------------------------LGPISGPQAFPKLVQILTAF-SSLQHLDL DALSEN-KIGDEG----------------------------------------------- ---------------------------VSQLSATFPQLKS-LETL--------------- ----------------------------------------------N--LSQNNITDLGA YKLAEALPSLA------------------------------------------------- ------------------------------------------------------------ ASL--LRL--SLYNNCICDVGAESL---ARVLPDM-VSLRVMDVQY--NKFTAAGAQQLA ASLRRC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PHVETL--AMWTPTIPFSVQEHLQQ------------- ---------------------------------------------------QDSRISLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >O_latipes_ENSORLP00000022795 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SKTIISSDAS IRCQDVFK-G--------LHD--QHGSIRVVLTSGVAGAGKSFSVQKFILDWAEGLENQD -ISVVVPLSFREVNL------IRDEQHSLLTMIQLFHPALQ-----RIPAEQL-D-VCKL LFIFDGLDESRLSL-DFNSG----QVVSNVAQKTSVNVLLTNLIQGHLLPSALVWITSRP AAASQIPTSCVD-RLTEVQGFSDAQKEE-YFR---KRFPD-----------------E-- -ELSHKMISHIKSSRSLCIMCEVPVFCWITAVVLENVLS---------KKRKGE-LPTTL TDMYSHFLMVQTQR--KKN-KYQKEDES----CPQNVTEADRDVFLKLGKLAFEHLENGN IMFYQEDLQQC--------------GLDVTEASV-YSGVCTEIFRRE----S-AIFQKSI YSFIHLSVQEFLAAVYM------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >H_sapiens_ENSP00000263437 ------------------------------------------------------------ ------------------------------------------------------MVSSAQ MGFNLQALLEQLSQDELSKFKYLITTF-------SLAHELQKIPHKEVDKADGKQLVEIL TTHCDSYWVEMASLQVF------EKMHRMDLSERAKDEVR-------------------- ------------------------------------------------------------ -------------------------EAALKSFNKRKPLSLGITRKERPPLDVDEMLERFK TEAQAFTETK-GNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWK--SWPGDS------ -KEVQ-VMA------------------------------------------------ERY KMLIPFSN-P--------RVL--PGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHK -FKYAFYLSCRELSR--------LGPCSFAELVFRDWPELQ-----DDIPHIL-AQARKI LFVIDGFDELGAAP-GALIE----DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRP RALRDLRILAEEPIYIRVEGFLEEDRRA-YFL---RHFGD-----------------E-- -DQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQME----KG----EDPVP-TCLTR TGLFLRFLCSRFPQ-----------------------GAQLRGALRTLSLLAAQGLWAQT SVLHREDLERL--------------GVQESDLRL-F--LDGDILRQD----R---VSKGC YSFIHLSFQQFLTALFYTLEKEEEEDR--------------------------------- ----------------DGHTWDIGDVQKLLSGVERLR----------------------- -------NPDLIQAGYYSFGLANEKRAKELEATFG--CRMS-P-DIKQELLRCDISCK-- ---------------GGHSTVTDLQELLGCLYESQEEELVKEVMAQFK-E-ISL--HL-- ------------------------------------------------------------ ------NAVDVVP----S-------SFCVKHCR---NLQKMSLQVI-KENLPENVTASES DAEVER-----SQDDQHMLPFWTDLCSIF----GSNKDLM----------GLAINDS--- FLSA-----SLVRILCEQIASDTCHLQRVVFKNISPA-DAHRNLCLALR-GHKTVTYLTL QGN-DQDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVN-QSLTCVN- --LSDN-ELLDEG-AKLLYTTLRHPKCFL------------------------------- -QRLS----------LENCH--LTEANCKDLAAVLVVSRE-LTHL--------------- ----------------------------------------------C--LAKNPIGNTGV KFLCEGLRYPE------------------------------------------------- ------------------------------------------------------------ CKL--QTL--VLWNCDITSDGCCDL---TKLLQEK-SSLLCLDLGL--NHIGVKGMKFLC EALRKPL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLRCL--WLWGCSIPPFSCEDLCSALS---------- ---------------------------------------------------CNQSLVTLD ------------------------------------------------------------ ---------------------------------------------LGQNP-LGSSGVKM- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ETLTCSSGT---LRTLR----LKIDDFNDELN-KLLEEIEEKNPQL IIDTEKHHPWAERPSSHDFMI------------------- >A_carolinensis_ENSACAP00000002201 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SSLSEAIQKHRNSLANWFLQQPNEERQFGPS------ -FALDSIHV---D------------PVIRETSLEEILKPSPDL----TIQNQLKASCNQT ISLQNLFD----------LNA--CGQPVRNVVLYGTVGTGKSTLIKKMVMDWCHERLPS- -FELLIPFSCEDLSQ-------SNAPISLRRLITKKYLHLR-----ELVPTLG-TTNFRV LFILNGLDRLNLDF-HLART----ELCCDPNEPIPPSAIVVNLLRKYMMPEASIIVTTRP SAVRRIPSKFVG-RYVEVCGFSDTNLQKLYFQ---MRLCQPGCVGVSGPPTAEEASKQ-- DNLVEMLSRNLERHNQIAAACFLPSYCWLVCTTLHFLYF----------TNSVP-PPQTL TGIYTSFLRLNFSGEVLDS-------------TDPSNISMMKYVAKTVGKLAHDGVISRK TSFSEEDMRRCFEAEMKKESELNLLDVFRSDVFRFF--LTPSVQSGK----------EHT FVFTIPIMQEYLAALYVVLGEKKTLMDRVGKDVSEIISKVSEDVAVVLSIVSKVLPLRIL PLLFNLIKIFPRYFTKFGSKDHDTIASTMAAEMFKEEDYFNDDVLEQTNCTILGVEGPMR HPDDAPDDEAFELFPIFTVGLLSRRNRSILDQLGCPITNLA-VLETAKAMKKKFIQKI-- ---------------RKGLPQPEVMDLLIFLHEFQNERFTAEAVQSLR-T-INLSTVK-- ------------------------------------------------------------ -----MTPLKCSI----L-------ASVVGATS--HEVEELNLGLC-HLDVNS------- ------------------------LRILF----PVLLRCK----------KLHLPQN--- GLGP-----EACKVIRDLLL---------------------------------------- --------------------HEKCAVSTLRLADNPLTEQGARYLAEGIAGN-RSLRQLS- --LLHT-SLGNRG----------------------------------------------- ---------------------------VEVITQHLAQNKH-LKEL--------------- ----------------------------------------------D--VAYNSVTDETA LALVEEVKRHP------------------------------------------------- ------------------------------------------------------------ -TL--NMV--HLYFNEISEEGKQAL---HQMRKDQ-DGIRVLIFLTIGTDVSDHWDTILN VVQKNLAVWDRDRVR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QHLGMLLEDLQCSRRQTANPLKKFKFMS---------- ---------------------------------------------------VENKVKRML GEL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >O_latipes_ENSORLP00000001933 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ECQTKMKSNLKERFQCLFEAIAKTGSR------ -TLLNEIYT---E------------LYITEGGAGGL-NEIHEVRLIEAA----LSKAERS IRHVDIFK-P--------PPD--RKEPIRTVMTKGVAGIGKTVLTQKFTLDWAEGKANQN -IHFIFPFTFRELNV------LK-KKFSLVELIHHFFPETK-----EAGIWSF-E-NFQV VFIFDGLDEYRIPL-DFHRT----QVLSDPKKPAKVGKLLTNLIRGNLLPSAHIWITTRP AAANQIPPQLIG-MVTEVRGFNDPQKEE-YFR---KRFRN-----------------K-- -SQSSRIISHIKTAQSLHIMCHIPVFCWITATVLDDLLK---------TKEVKK-LPRSL TEMYIHFLVIQAKV--KKI----------------------KTMMESLAKLAFEQLQKGN LIFYESDVTEC--------------GIDIRAASV-YSGVLTQIFVEE----R-GLYQDKV FCFIHLSIQEFLAALHVHI----------------------------------------- ----------------------------AVDKALQSP----------------------- -------NGHLDLVLRFLLGLSLQTNQNLLRGLLPQ-TESS-S-KAIEETIQYIKERI-- ---------------ERKQSTEKYINLFHCLNELNDNLLVEEIQHFLN-S-RSISTDK-- ------------------------------------------------------------ -----MSPAQWSA----L-------VFILLSSE--EDLEVFDLKGG-------------- -------------------SSEATASDQSLQQSSSGCCLV----------SFSLSGC--- NLSK-----KSCKKLSSLIGT-----------------------------ESSSLKELDL SNN-NLTDS-GVKLLSEGLQSPHCRLEVL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >E_caballus_ENSECAP00000018270 ------------------------------------------------------------ ------------------------------------------------------MASSFF SDFGLLWYLGELKKDEFRKFKDFLKQE-------PLQLGLKPIPWAEVRKATREGLANLL VKHYEEQEAWNVTFSIF------HKIHRKDLCEKAKKEIT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GHTKTYQAHIQEKFNNMWFRESVTRIH------ -DYFDQKTT-----------------------------------------------QKER ESLERLFA----------PKE--TGKQPRTVVFKGIQGIGKTTFLIKLMLAWAEGSLYQE RFFYVFYFCCREMKQ--------LTQTSLAALISRDWPNSH-----VPLTEIM-SQPERL LFVIDSFEELKHNL-DEPES----DLCSDWMEQRPVRVLLSSLLRKKMLPECSLLIAAAP VYPGEIEDRLVCPEIKTFLGFSESERKQ-YFC---CIFQD-----------------R-- -NRAMEAFSFVRENEQLFCMCQIPTLCWIVCTCLKHEME----RG----KDLAL-TCRRT TSLYTSFIFNLFTA--KGT---------------SCPDQQSQSQLKGLCSLAAEGMWTDT FVFSEEDLRRN--------------GLVDSDIPT-L--LDMKALQKY----R---ECENS YLFIHVCVQEFCAAMFYFLKSHIDHPN--------------------------------- --------------------PAVGCTETLLFTYLKKV----------------------- -------KVHWIYLGCFMFGLLNEKEQQKLDAFFG--FHLS-Q-EIQQKFRQCVQRIGES ---------------EHLQGEVDFLALCYCLFEMQNEAFVKWAMALFQ-D-VTF--SI-- ------------------------------------------------------------ -----VDSADLVT----S-------AYCLKHCS---RLRKLWLSIQ-NVFKEENAN---- -----------NPTSNYSFICWHHVCSVL----TTNENLT----------ELQVSDS--- SLNE-----SAFVTLCNQLRHPSCHLQKLWINNVSFS-AESWFFFEVLT-LSPDLKYLNL NGT-ALSRK-DVKLLCNALSNPKCNVEELLLTNCCLSADDCEAFTWVLNSN-NKLKLLN- --VSYN-YL-DKG-VPLLCKALRHPDCAL------------------------------- -EVLV----------LGYCY--LSGHCWKSLSDALLCNKS-LVHL--------------- ----------------------------------------------D--LSANVLKYEEL KLLCEALKQPS------------------------------------------------- ------------------------------------------------------------ CQL--QSL--CLLKCCITARGCQDL---ASVLTSN-QNLTGLQIGY--NDIEDVGAKLLC EALTHPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLENL--GLGACKLTSACCEDLSSALT---------- ---------------------------------------------------SSKTLRRLN ------------------------------------------------------------ ---------------------------------------------LSGNA-LDHGGVVV- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EALRCPECP---LQVLG----LKKDEFDEETQ-RLLMAEEERNPHL TIFS------------------------------------ >D_rerio_ENSDARP00000088285 ------------------------------------------------------------ ------------------------------------------------------------ -----------FLLEFLLEIKLFRSIMGNTHAAGDQDLSTECSSVHQKRAEAEPSCVSMK SDASMGVPITFKSENTG------------------------------------------- ------------------------------------------------------------ ----------------------PAVSSVHQKRAEAELSCVSMKSDASMNPPIEFKSGNTG PAV---RDGQTGDLQQDSLQPEHDELQRVKEQHKTSMKNKYERLFEGINHGETQ------ -TLLNRIYT---Q------------LYIIEGESEGV-NEEHEVLQMEKR-ARTKPSQHTP VYCNDIFKASAGAGHEEQIKK--EKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKDNQD -VDFMFVLPFRELNL------IRDHQYSLHRLLLDFHPKLE-----DLEPKIY-E-QCRV VFIFDGLDESRITL-NFSDE----EKVCAVTEPSSVAVLMRSLLKGDLLPSALIWITSRP AAAHQIPSTYIK-RLTEIQGFTEPQKEE-YFR---KRISD-----------------E-- -HQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE---------EDVSAE-IPQTL TEMYIHFLLIQINM--RKQ-KYEER-------DPEKLLQSNRGVILKLAEVAFRQLMKGN VMFYEEDLIES--------------GIDVTDASV-YSGICTEIFKEE----S-VIHQRKV YSFIHLSFQEFLAAFFVFYCHLTENREPLRVIYDS------------------------- ------EYSYNQYLQSSSEKSLYDLLSSAVVKAVWSS----------------------- -------NGHLDLFLRFLLGVSLDSNQRLFQDLLTH-TEES-S-ENIRRITQYI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >D_rerio_ENSDARP00000090800 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------QKRAEAEPSCVSMK SDASMGVPITFKSENTG------------------------------------------- ------------------------------------------------------------ ----------------------PAVSSVHQKRAEAELSCVSMKSDASMNPPIEFKSGNTG PAVSVDRDGQTGDLQQDSLQPEHDELQRVKEQHKTIMKNKYERLFEGINHGETQ------ -TLLNRIYT---Q------------LYIIEGESEGV-NEEHEVLQMEKR-ARTKPSQHTP VFCNDIFKASAGAGHEEQIKK--EKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKDNQD -VDFMFVLPFRELNL------IRDHQYSLHRLLLDFHPELE-----DLEPKIY-E-QCRV VFIFDGLDESRITL-NFSDR----QKVCAVTESSSVAVLMWSLLKGDLLPSALIWITSRP AAAHQIPSTYIK-RLTEIQGFTEPQKEE-YFR---KRISD-----------------E-- -HQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE---------EDVSAE-IPQTL TEMYIHFLLIQINM--RKP-KYEER-------DPEKLLPSNRGVILKLAEVAFRQLMKGN VMFYEEDLIES--------------GIDVTDASV-YSGICTEIFKEE----S-VIHQRKV YSFIHLSFQEFLAAFFVFYCHLTENREPLRVIYDE------------------------- ------KYAYDQYLQSSSEKSLYDLLSSAVVKAVWSS----------------------- -------NGHLDLFLRFLLGVSLDSNQRLFQDLLTH-TEES-S-ENIRRITQYIKDEIKR ---------------GKHLSAERSINLFLCLLEVKDQTLAREIQEFVK-S-DKHSEEE-- ------------------------------------------------------------ -----LTPAHCST----I-------SYMIEMSE--EPLDELDSNKF-NTSDVGRRRLI-- ---------------------------------AAVRNCR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RAL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_musculus_ENSMUSP00000104293 ------------------------------------------------------------ ----------------------------------------------------MLPSTARD GLYRLSTYLEELEAGELKKFKLFLGI--------AEDLSQDKIPWGRMEKAGPLEMAQLM VAHMGTREAWLLALSTF------QRIHRKDLWERGQGEDL-------------------- ------------------------------------------------------------ -------------------------------------------------------VRVTP NNGLCLFES---QSACPLDVSPNAPRKDLQTTYKDYVRRKFQLMEDRNARLGEC------ -VNLSNRYT----------------RLLLVKEHSNPIWTQQKFVDVEWERSRTRRHQTSP IQMETLFE-P--------DEE--RPEPPHTVVLQGAAGMGKSMLAHKVMLDWADGRLFQG RFDYVFYISCRELNR-------SHTQCSVQDLISSCWPERG-----ISLEDLM-QAPDRL LFIIDGFDKLHPSF-HDAQG----PWCLCWEEKQPTEVLLGSLIRRLLLPQVSLLITTRP CALEKLHGLLEHPRHVEILGFSEEARKE-YFY---RYFHN-----------------T-- -GQASRVLSFLMDYEPLFTMCFVPMVSWVVCTCLKQQLE----SG----ELLRQ-TPRTT TAVYMFYLLSLMQP--KPG----------------TPTFKVPANQRGLVSLAAEGLWNQK ILFDEQDLGKH--------------GLDGADVST-F--LNVNIFQKG----I---KCEKF YSFIHLSFQEFFAAMYCALNGREA------------------------------------ -------------------------VRRALAEYGFSE----------------------- -------RNFLALTVHFLFGLLNEEMRCYLERNLG--WSIS-P-QVKEEVLAWIQNKAGS ---------------EGSTLQHGSLELLSCLYEVQEEDFIQQALSHFQ-V-VVV-RSI-- ------------------------------------------------------------ -----STKMEHMV----C-------SFCARYCR---STEVLHLHGS-AYSTGMEDDPPEP SGVQTQSTYL-QERNMLPDVYSAYLSAAV----CTNSNLI----------ELALYRN--- ALGS-----QGVRLLCQGLRHASCKLQNLR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >O_latipes_ENSORLP00000018978 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------RTFSSASSAPDPLEIHKKRLFLWFSHLPKEEKQFGGS------ -FRPETMHV---D------------PLILE-------RRDEERSGLLHSPFQTNGPSSPP MTVEQLFH----------RTDSWTPDLGLNVLLYGAVGSGKDTVVRKLVLDWCCGTALTQ -FKLLLPFSCKDLSQ-------LSKAASLRDIVARKFLHLRNH---PLLSGNA-DQAKEV LFLFNGMEKMHL---DFGST----ELCSDPSEALPAAGVVVNLLRKYLLPEASILVTTRL SALDRIPSKYVS-RYAQICGFSDPDHQRAYFS---SRLLQRAGTDAPNPEA------E-- -ILVEQLYLNIQNKGRLATACFLPSYCWLTCATLHFLRF----------TSAQA-PVCTL TGIYTSFLTLNFGGEVLDS---------KTGISQDHYVSLMLYVVRTLGKLAFDGVTNKR RSFSEKELEQWIGGKTKTDEELRLLAIFQTDVLNFF--LEPCVENDKHLSHELGEDDERW YVFAVPAMQEYLAALYVVLGENKSALELLSKEFSTAIGQASEDVNALFNILSKFIPLRIF A-VFNLLKLFPKFFEKISRYNQGRIATTMTTAMFREEDSNNDDVLEQVEQSLLGFHGPA- -PQTYSKGRPFELYPIFMGGLLHYGNRVLLQQLGCNIQSST-VAQITRTLRKYLVKEL-- ---------------SKPLAADEQMDLLVLLYEIQNPRLTAEVLSSIR-S-ICLAQVC-- ------------------------------------------------------------ -----MTSLKCFI----L-------SSVLSCTNASYCLNKLDLSSC-LLNPGL------- ------------------------LQMLW----PALRHVR----------QLNLQFN--- NLGP-----DSCILLRDLLV---------------------------------------- --------------------EPKASVSSLQLCGNPLQDSGCCSLLEALPEN-HTLQHLS- --LVHT-GLGDHG----------------------------------------------- ---------------------------AQLLTTRLQQLSG-LQEL--------------- ----------------------------------------------N--VAYNNIGDEAA VALVEACRDHP------------------------------------------------- ------------------------------------------------------------ -SI--HTV--HLYLNPLSDAGKKSLYVRGENKKKY-QRVRVLASVTEGSNISEEWHPILS VIRENASTWDSKHVK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------DQLEVFLQDLEWGRQQQPSFWKRLHFRK---------- ---------------------------------------------------VERGVREIM ------------------------------------------------------------ -------------------------------------------QMVEEDALAASKGHTK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000019828 ------------------------------------------------------------ ------------------------------------------------MNFSVITCPNGG TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL DEHFPKGQAWKVVLGIF------QTMNLTSLCEKVRAEMK-------------------- ------------------------------------------------------------ -------------------ENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDPNQEELEE LEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKDH------ ------VYI-------------------------------------------RNTSKDEH EELQRLLD----------PNR--TRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQ RFSYVFYLSCHKIRY--------MKETTFAELISLDWPDFD-----APIEEFM-SQPEKL LFIIDGFEEIIISE-SRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKT WFVRDLKASLVNPCFVQITGFTGDDLRV-YFM---RHFDD-----------------S-- -SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKV----RY----YDLQS-ITQTT TSLYAYFFSNLFST--AEV---------------DLADDSWPGQWRALCSLAIEGLWSMN FTFNKEDTEIE--------------GLEVPFIDC-L--YEFNILQKI----N---DCGGC TTFTHLSFQEFFAAMSFVLEEPREFPP--------------------------------- ------------------HSTKPQEMKMLLQHVLLDK----------------------- -------EAYWTPVVLFFFGLLNKNIARELEDTLH--CKIS-P-RVMEELLKWGEELGKA ---------------ESASLQFHVLRLFHCLHESQEEDFTKKMLGRIF-E-VDL--NI-- ------------------------------------------------------------ -----LEDEELQA----S-------SFCLKHCE---RLNKLRLSVS-SHILERDLEILE- -----------TSKFDSRMHAWNSICSTL----VTNENLH----------ELDLSNS--- KLHA-----SSVKGLCLALKNPRCKVQKLTYKSVTPE-WVLQDLIIALQ-GNSKLTHLNL SSN-KLGMT--VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSI-QHVTRLC- --LGFN-RLQDDG-IKLLCAALTHPKCAL------------------------------- -ERLE----------LWFSQ--LAAPACKHLSDALLQNRS-LTHL--------------- ----------------------------------------------N--LSKNSLRDEGV KFLCEALGRPD------------------------------------------------- ------------------------------------------------------------ GNL--QSL--NLSGCSFTREGCREL---ANALSHN-HNVKILDLGE--NDLQDDGVKLLC EALKP-H----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALHTL--GLAKCNLTTACCQHLFSVLS---------- ---------------------------------------------------SSKSLVNLN ------------------------------------------------------------ ---------------------------------------------LLGNE-LDTDGVKM- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KALKKSTCR---LQKLG----------------------------- ---------------------------------------- >P_pygmaeus_ENSPPYP00000000034 ------------------------------------------------------------ -------------------------------------------------------MKMAS TRCKLARYLEDLEDVDLKKFKMHLEDY-------PPQKGCIPLPRGQTEKADHVDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLYEKAKRDEP-------------------- ------------------------------------------------------------ ------------------------------------------KWGSDNARVSNPTVICRE DSTEEEWMG---LLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGES------ -VSLNKRYT----------------RLRLIKEHRSQQEREQELLAIGKT--KMCESPVSP IKMELLFD-P--------DDE--HSEPVHTVVFQGAAGIGKTILARKIMLDWASGTLYQD RFDYLFYIHCREVSL--------VTQRSLGDLIMSCCPDPN-----PPIHKIV-RKPSRI LFLMDGFDELQGAF-DEHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -AQAKAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQME----SG----KSLAQ-TSKTT TAVYVFFLSSLLQP--RGG----------------SQEHCLCAHLWGLCSLAADGIWNQK ILFEESDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEEKEGRT--------------------------------- ------------NVPGSLLKLPSRDVTVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWIEVKAKA ---------------KKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCH---RVESLSLGFL-HNMPKEEEEEEKE G----------------------------------------------------------- ---------RHLDMVQCVLPGSSHAACSH------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >H_sapiens_ENSP00000269280 ------------------------------------------------------------ --------------------------------------------------------MAGG AWGRLACYLEFLKKEELKEFQLLLANK-------AHSRSSSGETPAQPEKTSGMEVASYL VAQYGEQRAWDLALHTW------EQMGLRSLCAQAQEGAGHSP--SFPYSPS-EPHLGSP SQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPD--H ESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREK SEKGRP-PW---AAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKN----------- -EDFNQKFT---Q------------LLLLQRPH----PRSQDPLVKRSWPDYVEENRGHL IEIRDLFG-P--------GLD--TQE-PRIVILQGAAGIGKSTLARQVKEAWGRGQLYGD RFQHVFYFSCRELAQ--------SKVVSLAELIGKDGTATP-----APIRQIL-SRPERL LFILDGVDEPGWVL-QEPSS----ELCLHWSQPQPADALLGSLLGKTILPEASFLITART TALQNLIPSLEQARWVEVLGFSESSRKE-YFY---RYFTD-----------------E-- -RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMK----RK----EKLTL-TSKTT TTLCLHYLAQALQA------------------------QPLGPQLRDLCSLAAEGIWQKK TLFSPDDLRKH--------------GLDGAIIST-F--LKMGILQEH--------PIPLS YSFIHLCFQEFFAAMSYVLEDEKGRGK--------------------------------- ------------------HSNCIIDLEKTLE-AYGIH----------------------- -------GLFGASTTRFLLGLLSDEGEREMENIFH--CRLS-Q-GR--NLMQWVPS---- ---------------LQLLLQPHSLESLHCLYETRNKTFLTQVMAHFE-E-MGM--CV-- ------------------------------------------------------------ -----ETDMELLV----C-------TFCIKFSR---HVKKLQLIEG-RQHR--------- ---------------------------------STWSPTM----------VVLFRWV--- PVTD-----AYWQILFSVLK------------------------------VTRNLKELDL SGN-SLSHS-AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRAN-QTLTELD- --LSFN-VLTDAG-AKHLCQRLRQPSCKL------------------------------- -QRLQ----------LVSCG--LTSDCCQDLASVLSASPS-LKEL--------------- ----------------------------------------------D--LQQNNLDDVGV RLLCEGLRHPA------------------------------------------------- ------------------------------------------------------------ CKL--IRL--GLDQTTLSDEMRQEL---RALEQEK-PQLLIFSRRK--PSVMTPTEGLDT GEMSNST----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SSLKRQ--RLGSERAASHVAQANLKLLD--VSKIFPIA EIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVH FPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAV EAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPS-FSPLGVLLK MIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPP LTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKK DETLVWEALVKPGDLMPATTLIPPARIAV-PSPLDAPQLLHFVDQYREQLIARVTSVEVV LDKLHGQVLSQEQYERVLAENTRPSQMRKLF----SLSQSWDRKCKDGLYQALKETHPHL IMELWEKGSKKGLLPLSS---------------------- >C_familiaris_ENSCAFP00000026585 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------FD-P--------DEE--GSSSSQTVVLQGCAGIGKTAVVHKFMYDWAAGMVTPG RFDYLIYVNCREINS--------IANLSAADLITNTFQDID-----GPILDVIPMYPEKL LFILDGFPELQCPV-DNQEE----DLSANPQEKKPVETLLCSFVRKKLFPESSLLITARP TTMKKLHSLLKQHIQAEIVWFTDAEKRA-YFL---SQFSG-----------------A-- -TVAMKVFYELQQNESLDIMSSLPIISWMICRVLQSQGD----GD----RTLMR-SLQTV TDVYLFYFSKCLKT--LTG----------------ISVWKGQSCLWGLCSLAADGLQNQQ VLFEVSDLRRH--------------GIGIYDMNC-T--FLNHFLKKV----K---GSASV YTFLHFSFQEFLTAVFYVLKNDSNWMF--------------------------------- ------------------FGQVGKTWQEIFQQYG-------------------------- -------KGFSSLTIQFLFGLLHKGKGKAVETIFG--RKIS-P-GLREELLKWTEKEIKD ---------------KSSRLQIEPMDLFHCLYEIQEEEYTKGIIDDLQ-S-IILLQPT-- ------------------------------------------------------------ -----YTKMDILA----M-------SFCVKSSH---NHLSVSLKCQ-HLLGFEEEERASA FIPPAS-----ALNQKRKKRKNMDIATLL----VVGPGFF-----------ISFRSSQLC NLPA-----SRLQLLCQALCNPYCKIKDLKFSSVRSCPFLLQSYSLVFE-TNQYLTDLEF VKN-TLEDS-GMKLLCEGLRKPNCVLQTLRLYRCLLSPASCGALAAVLSTS-QWLTDLE- --FSET-KLDALA-LKLLCEGLKDPNCKL------------------------------- -QKLKI---------LNSCRGLNSEVVCKYLASVLICNPN-LTEL--------------- ----------------------------------------------D--LSENPLGDTGV KYLCEGLRHSN------------------------------------------------- ------------------------------------------------------------ CKV--EKL--ELSECSLSAACCESL---SQVLSSS-RSLTRLLLIN--NKIEDLGLKLLC EGLKQPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CPLKDL--ALWTCHLTGECCQDLCNALY---------- ---------------------------------------------------TNEYLRDLD ------------------------------------------------------------ ---------------------------------------------LSDNA-LGDEGMQV- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EGLKQPSCK---LQTLW----LAECHLTDACC-GALASVLSRNENL TLLDLSGNDLKDFGVQMLCDALLQPICKLQTF-------- >D_rerio_ENSDARP00000088282 ------------------------------------------------------------ --------------------------------------------------KKKRCVSCLQ SASRPAFTLLHFLLEFLLEIKLFRSIMGNTHTAGDQDLSTGCSSVHQKRAEAEPSCVSMK SDQSMDEPRQFKSGNTG------------------------------------------- ------------------------------------------------------------ ----------------------PAVSSVHQKRAEAEPSCVSMKSDWSMNIPLTFRSENTR PAVSVDRDDQTGNLQQDSLQPEHDELQRVKEQHKTSMKNKYERLFEGINRGETQ------ -TLLNRIYT---Q------------LYIIEGESEGV-NEEHEVLQMEKR-ARTKPSQHTP VYCNDIFKASAGAGHEEKIKK--EKAQIKTVLTKGIAGIGKTVSVQKFILDWAEGKDHQD -VDFMFVLPFRELNL------IRDHQYSLHRLLLDFHPELE-----DLEPRIY-E-QCRV VFIFDGLDESRITL-NVSDE----EKVCAVTESSSVAVLMWSLLKGDLLPSALIWITSRP AAAHQIPSRYIK-RLTEIQGFTEPQKEE-YFR---KRISD-----------------E-- -HQASRIISHIRRARSLQIMCHIPVFCWISSTVLQKLLE---------EDESAE-IPQTL TEMYIHFLLIQINM--RKQ-KYEER-------DPEKLLQSNRGVILKLAEVAFRQLMKGN VMFYEEDLIES--------------GIDVTDASV-YSGICTEIFKEE----S-VIHQRKV YSFIHLSFQEFLAAFFVFYCHLTENREPLRVI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_pygmaeus_ENSPPYP00000011655 ------------------------------------------------------------ ------------------------------------------------------MVSSAQ MGFNLQALLEQLSQDELSKFKFLITTA-------SLAHELQKIPHKEVDKADGKQLAEIL TSHCDSYWVEMASIQVF------EKMHRMDLSQRAKDELR-------------------- ------------------------------------------------------------ -------------------------EAALKSLNKRKPLSLGITRKEQPPLDVEEMLEHFK AEALAFTETKEGNVTCLGKEVFKGEKPDKDNRYRYILKTKFREMWK--SWPGDS------ -KEVQ-VMA------------------------------------------------ERY KMLIPFSN-P--------RVL--PGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHK -FKYAFYLSCRELGR--------LGPCSFAELISKDWPELQ-----DDIPHIL-AQAQKI LFVIDGFDELGAAP-GALIQ----DMCRDWEKKKPVPVLLGSLLNRYMLPKAALLVTTRP RALRDLRFLVEEPIYIRVEGFLEEDRRA-YFL---RHFGD-----------------E-- -DQATRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQME----KG----EDTAP-TCLTR TGLFLRFLCSRFPQ-----------------------GAQLRGALWMLSFLAAQGLWAQM SVLHREDLERL--------------RVQESDLRL-F--LDGDILRQD----T---VSKGC YSFIHLSFQQFLTALFYALEKEEEEDR--------------------------------- ----------------DGHAWDIGDIQKLLSGEERLR----------------------- -------NPDLIQAGYYSFGLANEKRAKELEATFG--CRIS-P-DIKQELLQCDISCK-- ---------------GGHSTVTDLKELLGCLYESQEEELVKEVMAQFK-E-ISL--HL-- ------------------------------------------------------------ ------NAVDVVP----S-------SFCLKHCQ---NLQKMSLQVI-QANLPENVTASES DAEVER-----SQDDQHVLPFWMDLCSIF----GSNKDLM----------GLAINNS--- FLSA-----SLVRILCEGIASDTCHLQRVVFKNISPA-VFNRNLCLALR-GHKTVTYLT- QGN-DQND--MLPALCEVLRHPECNLRYLGLVSCSTTTQQWADLSLALEVN-QSLTCVN- --LSDN-ELLDEG-AKLLYTTLRHPKCLL------------------------------- -QRLS----------LENCH--LTEANCKDLAAVLVVSRE-LTHL--------------- ----------------------------------------------C--LAKNPIGDTGV ELLCEGLRYPE------------------------------------------------- ------------------------------------------------------------ CKL--QTL--VLWNCNITSNGCCNL---AKLLQEK-SSLSCLDLGL--NYIGVSGMKLLC EALRKPL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLRCL--WLWGCSIPLFSCEDLCSALS---------- ---------------------------------------------------CNQSLVTLD ------------------------------------------------------------ ---------------------------------------------LGQNP-LGSSGVKM- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ETLTHPNGT---LRTLR----LKIDDFNDELN-KLLEEIEEKNPQL IIDTEKHDPWKKRPSSHDFVI------------------- >O_latipes_ENSORLP00000004917 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HGQTGDREVN FKLENVLE-P--------LPG--ETEPIRLVMTVGGAGIGKTILTQKFTLDWAEGKNNQD -IHFIFQIPFRKMSV------LKDGTCSFVDLVHQFFPEIR-----EEGIYSF-K-EFKV LFILDGLDECQLPF-NFKNP----QTLSDITVSASKDVLLTNLIIGNLVPSAQLWITTRP AAASQIPSKFIS-RKIEVRGFNDQQKEE-YFR---KRFTD-----------------K-- -EQANMIISHIKTSRSLFIMCHIPVFCWITAKVLETVMI---------KEKNTD-LPKNL TELYLRFLRLNIEK--KSY-LMDDGGAT-------RDHPSLEKMIESLGKLAFEQLKKNQ TIFKHHDIEEC--------------NINIENTSL-YLGVFNQIFKKD----KCEMFVNKE YSFMHLTFQEFLAALYA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >P_troglodytes_ENSPTRP00000053771 MNNFQAILTQVRMLLSSHQPSLVQALLDNLLKEELLSREYHCTLLHEPDSEALARKISLT LLEKGDLDLALLGWARSGLQPPAAERGPGHSDHGGSSQCATMELGPL-EGGYLELLNSDA DPVCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELD QYVFQDSQLEGLSKDIFIEHIGPDEVIGESMEMPAEVGQKSQK---RPFPEELPADLKHW K-------------------------------------------------PVPSSSSSLS CLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGE-VPQASQVPPPSGFTVHGL PTSPDRPGS---TSPFAPSATDLPSMPEPALTSRANMTEHKTSPTQCQAAGEVSNKLPKW PEPVEQFYRSLQDTYCAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQ GGLAEVLL-A--------AKEHRRPRETRVIAVLGKPGQGKSYWAGAVSRAWACGRLPQ- -YDFVFSVPCHCLNR-------PGDAYGLQDLLFSLGPQPLVAAD-EVFSHIL-KRPDRV LLILDAFEELEAQD-GFLHS----TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARP RGRLVQSLSKAD-ALFELSGFSMEQAQA-YVM---RYFES-----------------SGM TEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLE---------LGEDAK-LPSTL TGLYVGLLGRA-------------------------ALNSPPGALAELAKLAWELGRRHQ STLQQDQFPSA--------------DVRTWAMAKGL--VQ-----------HPPGAAESE LAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTP------------------------ -------------------------------RKKRPY----------------------- -------DNWLEGVPRFLAGLIFQPRARCLGALVGP-SAAALADRKQKVLARYLKRLQ-- ---------------PGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGR-LSFLGTR-- ------------------------------------------------------------ -----LTPPDAHV----L-------GKALEAAG---QDFSLDLRST-GICPSGLGSLVGL SCVTRFRAALSDTVALWESLRQHGETKLL---QAAEEKFT----------IEPFKAKSLK DVED-------LGKLVQTQR-----TRSSSEDTAGELP------------AVRDLKKLEF A------------------------------LGPVSGPQAFPKLVRILTAF-SSLQHLDL DALSEN-KIGDEG----------------------------------------------- ---------------------------VSQLSATFPQLKS-LETL--------------- ----------------------------------------------N--LSQNNITDLGA YKLAEALPSLA------------------------------------------------- ------------------------------------------------------------ ASL--LRL--SLYNNCICDVGAESL---ARVLPDM-VSLRVMDVQY--NKFTAAGAQQLA ASLRRC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PHVETL--AMWTPTIPFSVQEHLQQ------------- ---------------------------------------------------QDSRISLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >O_latipes_ENSORLP00000000732 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RQKVQSGLKKKFQCVFEGIAKAGNP------ -TLLKEIYT---E------------LFISEQGTEEL-NEEHEVRQIEAA-SRKADRAEKT IRQEKLFQ-L--------PAG--RQEPIRTVMTKGVAGIGKTVLTQKFTLDWAEGKAHQN -LHFIFPFTFRELNV------LKEEKFSLVELVHHFFPETK-----EAGICSF-E-HFQV IFIFDGLDECRLPL-DFQT-----QILNDPRKPTSIGDLLTNLIRGNLLPSARLWITTRP AAANLIPAECVD-MVTEVRGFNDPQKEE-YFR---KRFRD-----------------E-- -EQASMIVSHIKRSRSLHIMCHIPVFCWITATVLEDLLR---------TKEGEK-LPKSL TEMYIHFVVVQAKV--KKV-KYDGG--------------ESRKMMESLGELAFEQLQKGN LIFYESDLTEC--------------GIDIRAASV-YSGVFTQIFREE----R-GLYQDKV FCFIHLSVQEFLAALHVHLTFINPGLNLMEGERES------------------------- ------------KIVNEKQNISVQFYQSAVNMALECQ----------------------- -------SGDMDLFLRFLLGLSLPTNQSLLRGLQTQ-TGSS-P-QTNKETVLYIKEKI-- ---------------SENLSAEKSINLFHCLNELNDGSLVEEIQQSLR-----LSDCK-- ------------------------------------------------------------ -----LSEKSGAA----L-------SSVLSSQS--SRLRDLDLTFFEGFLFPPQKKKK-- -----------------KNHSFDLILEYFPSSKQSACSHA----------AFRLKSC--- SLSE-----ISCEPLGSVLKS-----------------------------NPSNLKELDL SRN-ILQDS-GFLHLRGFLESPDCRLQMLRLESCKFSKTSCEFLGSALKSNPSYLRELD- --LSRN-ILQDSG-FLHLRGFLESPDCRL------------------------------- -ETLR----------LKNCS--LSEISCKALVSALKSDPSNLTEL--------------- ----------------------------------------------D--LSWNTIKDSGV LHLRRFLESSD------------------------------------------------- ------------------------------------------------------------ CRL--QTL--RLEDCRLSEISCKVL---GSALESSLSKLTKLDLSR--NTLQDSGALYLC GFLESPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRLQTL--RLEKCSLSKISCESLGSALK---------- --------------------------------------------------NSPSKLTELD ------------------------------------------------------------ ---------------------------------------------LGMNN-LQESDVQQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------FQDLVKSSICKLQTLR----SVEGWISAESPAALSSKKQTKKEKV LLHQPNA--------------------------------- >M_mulatta_ENSMMUP00000011259 ------------------------------------------------------------ --------------------------------------------------MADSSSSSFF PDFGLLLYLEELNKEELNTFKLFLKE--------TMEPEHGLIPWNEVKKARRDDLANLM KKYYPGEKAWSVTLKIF------GKMNLKDLCQRAKEEIN-------------------- ------------------------------------------------------------ ---------------------------------------------------WSAQSIGPD DAKVGVTQ-------------DQEAVLGDGTEYRIRIKEKFCITWDKKSLAGKH------ -EDFHHGIA-----------------------------------------------EKDR KLLEHLFD-V--------DVK--TGEQPQTVVLQGAAGVGKTTLVRKAMLDWAEGNLYQQ RFMYVFYLNGREINQ--------LRERSFAQLISKDWPSTE-----GPIEEII-SQPSSL LFIIDSFDELNFAF-EEPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL TTSKRLKQLLKNHRYVELLGMSEGAREE-YIY---QFFED-----------------K-- -RWAMKAFSSLKSNEMLFSMCQVPLVCWATCTCLKQQME----KG----GDVTL-TCQTT TALFTSYISSLFTP--VDG---------------CSPRLPNQVQLRRLCHVAAKGIWTMT YVFYRENLRRF--------------GLTKSDVSS-F--LSNNIIQKD----T---EYENC YVFTHLHVQEFFAAMFYMLKGNWEAGN--------------------------------- -----------------PSCQPFEDLKSLLQ-STSYK----------------------- -------DPQLRQMKCFLFGLLNEDRVKQLERTFN--CKMS-L-KIKSKLLQCMEVLGNS ---------------DYSPSQLGFLELFHYLYETQDKAFISQAMRYFS-K-VAI--NI-- ------------------------------------------------------------ -----CEKIHLLV----S-------SFCLKHCR---CLRTIRLSVT-TVFEKKTLKTSLP TNTW---------DGDRITHWWQDLCSVL----HTNEHLR----------ELDLCHS--- NLDK-----SAMNILHQELRHPNCKLQKLLLKCITFP-DGCQDISTSLI-HNQNLMHLDL KGS-DIGDN-GVKSLCEALKHPECKLQTLRLESCNLTVFCCLSIFNVLIRS-QSLIFLN- --LSTN-NLLDDG-VQLLCEALRHPKCYL------------------------------- -ERLS----------LESCG--LTEAGCEDLSLALISNKR-LTHLCLADNVLGDGGVKLM SDALQHAQCTLQSLVSEQ-KYSTLFSEYLSTSLLHNKSLTHL----D--LGSNWLQDNGM KLLCDVFRHPS------------------------------------------------- ------------------------------------------------------------ CNL--QDL--ELMGCVLTNACCLDL---ASVIVYN-PNLRSLDLGN--NNLQDDGVKILC DALRYPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNIQRL--GLEYCGLTSLCCQDLSSALI---------- ---------------------------------------------------CNQRLIKMN ------------------------------------------------------------ ---------------------------------------------LTQNT-LGYEGIMK- ----LY------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KVLKSPKCK---LQVLG----LCKEAFDEEAQ-KLLEAVGVSNPHL IIKPDCNYHNEENGSWWRCF-------------------- >G_gorilla_ENSGGOP00000004737 ------------------------------------------------------------ -------------------------------------------------------MKMAS TRCKLARYLEDLEDVDLKKFKMHLEDY-------PPQKGCIPLPRGQTEKADHVDLATLM IDFNGEEKAWAMAVWIF------AAINRRDLYEKAKRDEP-------------------- ------------------------------------------------------------ ------------------------------------------KWGSDNAHVSNPTVICRE DSIEEEWMG---LLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGES------ -VSLNKRYT----------------RLRLIKEHRSQQEREQELLAIGKT--KTCESPVSP IKMEMLFD-P--------DDE--HSEPVHTVVFQGAAGIGKTILARKIMLDWASGTLYQD RFDYLFYIHCREVSL--------VTQRSLGDLIVSCCPDPN-----PPIHKIV-RKPSRI LFLMDGFDELQGAF-DEHIG----PLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRP VALEKLQHLLDHPRHVEILGFSEAKRKE-YFF---KYFSD-----------------E-- -AQARAAFSLIQQNEVLFTMCFIPLVCWIVCTGLKQQME----SG----KSLAQ-TSKTT TAVYVFFLSSLLQP--RGG----------------SQEHRLCAHLWGLCSLAADGIWNQK ILFEESDLRNH--------------GLQKADVSA-F--LRMNLFQKE----V---DCEKF YSFIHMTFQEFFAAMYYLLEEEKEGRA--------------------------------- ------------NVPGSRLKLPSRDVTVLLENYGKFE----------------------- -------KGYLIFVVRFLFGLVNQERTSYLEKKLS--CKIS-Q-QIRLELLKWIEVKAKA ---------------KKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFP-K-IEI--NL-- ------------------------------------------------------------ -----STRMDHVV----S-------SFCIENCH---RVESLSLGFL-HNMPKEEEEEEKE G----------------------------------------------------------- ---------RHLDMVQCVLPGSSHAACSHGLVNSHLXXXXXXXXXXXXX-XXXXXXXXXX XXX-XXXXX-XXXXXXXXXXXXXXXXXXXXLGRCGLSHECCFDISLVLSSN-QKLVELD- --LSDN-ALGDFG-IRLLCVGLKHLLCNL------------------------------- -KKLX----------XXXXX--XXXXXXXXXXXXXXXXXX-XXXX--------------- ----------------------------------------------X--XXXXXXXXXXX XXXXXXXXXXX------------------------------------------------- ------------------------------------------------------------ XXX--XXX--XLVNSGLTSVCCSAL---SSVLSTN-QNLTHLYLRG--NTLGDKGIKLLC EGLLHPD----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CKLQVL--ELDNCNLTSHCCWDLSTLLT---------- ---------------------------------------------------SSQSLRKLS ------------------------------------------------------------ ---------------------------------------------LGNND-LGDLGVMM- ----FC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVLKQQSCL---LQNL------------------------------ ---------------------------------------- >H_sapiens_ENSP00000343891 ------------------------------------------------------------ ------------------------------------------------MNFSVITCPNGG TNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLL DEHFPKGQAWKVVLGIF------QTMNLTSLCEKVRAEMK-------------------- ------------------------------------------------------------ -------------------ENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQDPNQEELDE LEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPKDH------ ------VYI-------------------------------------------RNTSKDEH EELQRLLD----------PNR--TRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQ RFSYVFYLSCHKIRY--------MKETTFAELISLDWPDFD-----APIEEFM-SQPEKL LFIIDGFEEIIISE-SRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKT WFVRDLKASLVNPCFVQITGFTGDDLRV-YFM---RHFDD-----------------S-- -SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKV----RY----YDLQS-ITQTT TSLYAYFFSNLFST--AEV---------------DLADDSWPGQWRALCSLAIEGLWSMN FTFNKEDTEIE--------------GLEVPFIDS-L--YEFNILQKI----N---DCGGC TTFTHLSFQEFFAAMSFVLEEPREFPP--------------------------------- ------------------HSTKPQEMKMLLQHVLLDK----------------------- -------EAYWTPVVLFFFGLLNKNIARELEDTLH--CKIS-P-RVMEELLKWGEELGKA ---------------ESASLQFHILRLFHCLHESQEEDFTKKMLGRIF-E-VDL--NI-- ------------------------------------------------------------ -----LEDEELQA----S-------SFCLKHCK---RLNKLRLSVS-SHILERDLEILE- -----------TSKFDSRMHAWNSICSTL----VTNENLH----------ELDLSNS--- KLHA-----SSVKGLCLALKNPRCKVQKLTCKSVTPE-WVLQDLIIALQ-GNSKLTHLNF SSN-KLGMT--VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSI-QHVTRLC- --LGFN-RLQDDG-IKLLCAALTHPKCAL------------------------------- -ERLE----------LWFCQ--LAAPACKHLSDALLQNRS-LTHL--------------- ----------------------------------------------N--LSKNSLRDEGV KFLCEALGRPD------------------------------------------------- ------------------------------------------------------------ GNL--QSL--NLSGCSFTREGCGEL---ANALSHN-HNVKILDLGE--NDLQDDGVKLLC EALKP-H----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALHTL--GLAKCNLTTACCQHLFSVLS---------- ---------------------------------------------------SSKSLVNLN ------------------------------------------------------------ ---------------------------------------------LLGNE-LDTDGVKM- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KALKKSTCR---LQKLG----------------------------- ---------------------------------------- >T_rubripes_ENSTRUP00000005729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HKISLKRRSEHVTEGTNEAGSG------ -TLLSKIYT---E------------LYITEGQSEEV-NTQHEVRQLEIT--SKKNVQDTP IRCHQIFN-I--------LCE--QQKHVRVVLTNGVAGVGKTFSVQKFTLDWAEGLENQD -ISLLVLLSFRELNL------IKDEQHSLLSLLHVFHPTLQ-----KIRAEDL-T-ACKL LLIFDGLDESRLSL-DFNKE----QVISDVTQVSSASVLLVNLIQGNLLPSALIWITSRP AAANQIPPSYVD-RITEIRGFTDTQKEE-YFR---RRFSD-----------------E-- -DLSKRIISHLKASRSLHIMCLIPVFCWITATVLEHMLT---------TEQRGE-LPKTL TDLYSHFLLVQTKR--KKQ-KYGG--HK----GPEELTESDKEVLLKLGRLAFEHLENGN ILFYQNDLEQC--------------GLDVSEVSV-YSGVCTEIFRRE----T-VIFQKSV YCFVHLSIQEFLAAVYMFHCYT-------------------------------------- ----------------------NDFLSRVMKKSLESP----------------------- -------NGHLDLFVRFLHGLSLESNQRILGGLLNQ-TDNN-P-ETIQKVINNLKEMS-- ---------------SEQISPDRSINIFHCLMEMKDHSVHQEIQEFLK-S-ERKSEQE-- ------------------------------------------------------------ -----LSEIQCSA----L-------AYLLQMSE--EVLDELNLKEY-NTSEEGRRRLI-- ---------------------------------PAVRNCR-------------------- ------------------------------------------------------------ ---------------------------KAELWGCSLSEISCGSLASALKSNPSHLRELN- --LGYN-KLQDSG-VKLLCSGLESPNCKL------------------------------- -ETL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_musculus_ENSMUSP00000073732 MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCALLHEPDGDALARKISLT LLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATMDLGSP-EGSYLELLNSDA DPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQDMELDEETREAYANIAELD QYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQKPQK---RRFPEEHAMDSKHR K-------------------------------------------------LVPTSRTSLN YLDLPTGHIQI---FTTLPQGLWQISGAGTGLSSVLIYHGE-MPQVNQVLPSSSLSIPSL PESPDRPGS---TSPFTPSAADLPSMPEPALTSRVNETE-DTSPSPCQEGPESSIKLPKW PEAVERFQHSLQDKYKALPQSPRGPLVAVELVRARLERGSNKSQERELATPDWTERQLAH GGLAEVLQ-V--------VSDCRRPGETQVVAVLGKAGQGKSHWARTVSHTWACGQLLQ- -YDFVFYVPCHCLDR-------PGDTYHLRDLLCPPSLQPLAMDD-EVLDYIV-RQPDRV LLILDAFEELEAQD-GLLHG----PCGSLSPEPCSLRGLLAGIFQRKLLRGCTLLLTARP RGRLAQSLSKAD-AIFEVPSFSTKQAKT-YMR---HYFEN-----------------SGT AGNQDKALGLLEGQPLLCSYSHSPVVCRAVCQLSKALLE---------QGTEAQ-LPCTL TGLYVSLLGPA-------------------------AQNSPPGALVELAKLAWELGRRHQ STLQETRFSSV--------------EVKTWAVTQGL--MQ-----------QTLETTEAQ LAFSSFLLQCFLGAVWLAQCNEIKDKELPQYLALTP------------------------ -------------------------------RKKRPY----------------------- -------DNWLEGVPRFLAGLVFQPRAHCLGALVEP-AVAAVADRKQKVLTRYLKRLK-- ---------------LGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPGH-LSFLGTR-- ------------------------------------------------------------ -----LTPPDVYV----L-------GRALETAS---QDFSLDLRQT-GVEPSGLGNLVGL SCVTSFRASLSDTMALWESLQQQGEAQLL---QAAEEKFT----------IEPFKAKSPK DVED-------LDRLVQTQR-----LRNPSEDAAKDLP------------AIRDLKKLEF A------------------------------LGPILGPQAFPTLAKILPAF-SSLQHLDL DSLSEN-KIGDKG----------------------------------------------- ---------------------------VSKLSATFPQLKA-LETL--------------- ----------------------------------------------N--LSQNNITDVGA CKLAEALPALA------------------------------------------------- ------------------------------------------------------------ KSL--LRL--SLYNNCICDKGAKSL---AQVLPDM-VSLRVMDVQF--NKFTAAGAQQLA SSLQKC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PQVETL--AMWTPTIPFGVQEHLQQ------------- ---------------------------------------------------LDARISLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >M_mulatta_ENSMMUP00000022013 ------------------------------------------------------------ ------------------------------------------------MSFSVTTWADSG TNQGLLPYLVALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPHIPWANLRAADPFNLSFLL EEHFPNGQAWKVVLGVF------QTMNLTSLCEEVRAKMK-------------------- ------------------------------------------------------------ -------------------GNVQTQELQGPTQEDVEMLEAAAGNMQTQGCQDPNQEEPEE PEEETGNVQVQGCQDLNQEEPEMLEEADHRRKYREKMTAKLLETWDKIDWPKDH------ ------VYI-------------------------------------------RNTSEGEH EELQRLLD----------PKR--TRTQAQTIVVVGRAGVGKTTLAMQAMLHWANGVLFQE KFSYVFFLSCHKIRY--------MKETSFAELISLDWPDSD-----APIEEFM-SQPEKL LFIIDGFEEIIISE-PSSESLNDGSPCTDWYQELPVTKILLSLVKKELVPLATLLITIKN CFVIDLKPSLVNPCFVQITGFTEEDLWV-YFM---RHFED-----------------S-- -REVEKILQQIRKNENLFHSCSAPMVCWTVCSCLKLSKV----RY----YDLQS-ITQTT TSLYAYFFSNLFST--AEV---------------DLADESWPGQWRALCNLAMEGLWSIN FTFDREDTELE--------------GLEVPFIDC-L--YKFNIIQKG----N---DCRGC ITFTHLSFQEFFAAMSFVLEEPRELLP--------------------------------- ------------------HSTKPQEMKILLRDVLLNK----------------------- -------EAYWTPVVLFFFGLFKKNLARELEDTLH--CKMS-P-RVMEELLKWGEELGKA ---------------ESASLQFHVLQLFHCLHESQEEDLAKKMLGHIF-E-VDL--NI-- ------------------------------------------------------------ -----PGDEELQA----S-------SFCLKHCK---RLNKLRLSVS-SHILERDLEILE- -----------TSEVDSRMHAWNSICSTL----VTNENLH----------ELDLSNS--- KLHA-----SSVKGLCLALKNPRCKVQKLTCKSVTPE-WVLQDLIPVLQ-GNSKLTHLNF SSN-KLGAT--VPLILKALKHSACNLKYLCLEKCSLSAASCQDLALFLTSI-QHITRLC- --LGFN-QLQDDG-IRLLCAALTHPKCAL------------------------------- -ERLE----------LWFCQ--LGAPSCRYLSDALLQNRS-LAHL--------------- ----------------------------------------------N--LSKNRLGDEGV KFLCEALGRPD------------------------------------------------- ------------------------------------------------------------ CNL--QSL--NLSGCSFTREGCREL---ANALKHN-HNVKILDLGQ--NDLQDDGVKLLC EALKPSH----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RALHTL--GLAKCNVTTACCQHLSSVLS---------- ---------------------------------------------------SSKSLVNLN ------------------------------------------------------------ ---------------------------------------------LLGNE-LDHDGVKM- ----LC------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KALRKSTCR---LQKLG----------------------------- ---------------------------------------- >X_tropicalis_ENSXETP00000019213 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------HR--KRCVPQAVLVSGVPGVGKTTLMQKFVYDWANGNLYQR -FAFVFFFKFRDLNN--------KEELSLAQMIINEYPYLH-----SQLDRIF-RNPEKL LFVFDGLDKNKSST-DFKSS----KLCTNPHSIGTLNVIVSSLVRQSLLPGCSVLISSRP TRLATVKTSVFH-RILEIMGFFPKEREK-YFL---HFFRD-----------------Y-- -TMAEKAFHYVRENGMLYTFCYIPSYCWIICTVLSMCFR----AQRANSAQAVEFLPKTV TQLYASFISNILANHCQAG-------------------SIDKNFLISIGRMAEYGVSNQI LSFTKDDLETF--------------NVDTSSH------LATSFVIES------GQPPHVS YSFLHLTIQEFMAALGHYLDYSPEG----------------------------------- -------------------------LQKALEEAKSTE----------------------- -------DGRGEIFLRFISGLSDSSTRSLLKPYVGD-LSA----PAAKHVISFLQKSIIT ---------------LQNPDNRKVLNVFACLAESRNKALVSSSIGSNK-Q-FQFSEFY-- ------------------------------------------------------------ -----LVPLDCTV----L-------AFILESCR---ETELLDLGDL-HVLKDVHSLLSCL RNNGL-------------------TEDSC----AALTLAV---EGNNSLRDLDLSKN--- KLSG-----KDLNKLLEVLSAPACRIERLGNFFGDAGYPHIQKLIL----EHPSLREIRL TNN-NLRDE-DVPCLYSILTHRQCRIQRCSLRNNGLTELSCLPMALAVSEN-TSLRDLD- --LSKN-KLAGED-FYQLLKVLSAPTCRI------------------------------- -ERLA----------LQEAK--LTPEYTESFLS-LTNNPN-LVSL--------------- ----------------------------------------------K--LTNNNLRDEDV PRIYSILTHLQ------------------------------------------------- ------------------------------------------------------------ CRI--QRL--SLRNNGLTETSCLPM---ALAVSEN-TSLRDLDLSK--NKLAGEDFYQLL EVLSAPT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CRIECL--ALQEAKLTPEYTESFLSLT----------- ---------------------------------------------------NNPNLVSLN ------------------------------------------------------------ ---------------------------------------------ISSNF-FGDAGYPH- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------IQKHILTHPSLREIR----LQEAKLTPEYTESFLSLTNNPNLVS LNISSSFFGNAG---------------------------- >O_latipes_ENSORLP00000000432 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------E------------LFITEGGRGEL-NEEHEVRQIEAA-SRKADRAETS IRQEELFQ-L--------PAG--RQEPIRTVMTKGVAGIGKTVLTQKFTLDWAEGKAHQN -LHFTFPFTFRELNVLKEENVLKEEKFSLVELVHHFFPETK-----QAGICSF-K-YFQV LFIFDGLDECRLPL-DFHKT----QIVNDPRKPTSVANLLTNLIRGNLLPSARLWITTRP AAANQIPAECVD-MVTEVRGFDDPQKEE-YFR---KRFRD-----------------E-- -EQASRIISHIKRSRSLHIMCHIPVFCWITATVLEDLLK---------SREGGK-LRKSL TEMYFHFLVVQAKV--KKG-TYYGGTET-----DPHWSPGSRKMMESLGKLAFEQLQKGN LIFHKSDLTEC--------------GIDIRAASV-YSRMFIQIFREE----R-GLYQDKV FCFIHLSVQEFLAALHVHLTFITSGVNLMEDEQKK------------------------- ---------KSLKILKLKKSGPVQFYQSAVEKTLESP----------------------- -------NGHLDLFLRFLLGLSSQTNQNLLRGLLTQ-TGSS-S-QTNQETVQFIKEKI-- ---------------SEDLPTEKSINLFHCLNELNDGPPVKEIQQSLR-----LSDCN-- ------------------------------------------------------------ -----LSKRSCVA----L-------SSV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------- >E_caballus_ENSECAP00000014445 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FHYSIT------------------------------------------------QRS QKFITFLN-P--------QIS--TQLMPLTVVLHGPAGVGKTTLAKKWMVDWTQDNHAKT -FNSTFYLSCKELNH--------KGECSFADLLSKNWPDLQ-----DAVPEIL-TQAQKI LFIIDGFEELRVPS-EALIH----DMCCDWQKQKPVPVLLGSLLKRKMLPKATLLITTRP GALRELGLLVEQPFFIEIEGFLELDRKA-YFL---KHFEE-----------------E-- -AQALRAFDLMKSNAALFHLGSAPAVCWIVCTCMKLQME----KG----EDPAP-TCQTI TSLFLHFLCSQFTS--PPG---------------SCPGPFLQVPVTALCLLAAEGIWTQT SMFDGEDLERL--------------GVKESDFHP-F--LDKNILQKG----K---DCEGC YSFIHLSVQQFLAALFYVLEREEEEDG--------------------------------- ----------------DSCRWDIGGVQKLLSKEERLK----------------------- -------NPSLTHVGYFLFGLLNEKRAGELETTFG--CQVS-R-KVKQELLEFRVKSNKN ---------------KRLSSVTDMKEVLYCLYESQEEQLVKNAMSYVK-E-ISI--HL-- ------------------------------------------------------------ -----TNTFEMMQ----S-------SFCLKHCE---NLQKISLQVE-KGIFLENDTESEL D----------AQCDHRSLPLWTDLCSVF----SSNKNLS----------FLDVSQS--- FLSH-----SSVRILCEQITRVTCHLQKVVIKNISPS-DAYRDLCLAFI-GKKTLTHLIL EGD-VHTDKMLLLLLCEMLKHSRCNLQYLRLGSCCDAAQKWDDSSLALGIN-QSLRCLD- --LTAS-ELLDEG-VKLLCTTLRHPKCFL------------------------------- -QKLS----------LENCH--LTEACCKELSSTLIVNQR-LTYL--------------- ----------------------------------------------C--LANNKLGDGGV KLLCEGLSYPE------------------------------------------------- ------------------------------------------------------------ CQL--QTL--VLWHCNITRRGCKLI---SKLLQGD-SSLTNLDLGL--NPIA-TGLWFLC EALKKPN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CNLKYL--GLWGCSITPSCCQGLASALI---------- ---------------------------------------------------SNQRLETLD ------------------------------------------------------------ ---------------------------------------------LGQNV-LGKNGIMM- ----LF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EALKQNDGP---LKTLR----LKVDESSVEVQ-KLLKDVKDSNPKL TIECNNARTTRSSCCDFFS---------------------