10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYV--------- P_troglodytes_ENSPTRP00000018245 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYV--------- M_mulatta_ENSMMUP00000004228 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGGERCPQNVGWMPGLNERTRQRGDFPGTYV--------- B_taurus_ENSBTAP00000003033 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGNERCPQSVGWMPGLNERTRQRGDFPGTYV--------- C_familiaris_ENSCAFP00000022072 M----------------------------------AGAEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQVLG-VAEGNERCPQSVGWMPGLNERTRQRGDFPGTYV--------- M_musculus_ENSMUSP00000034296 M----------------------------------AGAEGFQYRAVYPFR-RERPEDLELLPGDLLVVSRVALQALG-VADGGERCPHNVGWMPGFNERTRQRGDFPGTYV--------- R_norvegicus_ENSRNOP00000026210 M----------------------------------AGAEGFQYRAVYPFR-RERPEDLELLPGDLLVVSRVALQALG-VADGGERCPHNVGWMPGFNERTRQRGDFPGTYV--------- P_pygmaeus_ENSPPYP00000010903 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYV--------- O_anatinus_ENSOANP00000002082 M----------------------------------ASTEGFQYRALYQYH-KEREEDIDLLPGDILVVSKGALQALG-FRDGDEQNPYQIGWIPGVNEHTNQKGGFPGTYV--------- G_gallus_ENSGALP00000005414 M----------------------------------GSTDGFQYRALYPYR-KEREEDIDLVPGDILVVSKGALQALG-FKDGDEQNPNQIGWILGVNERTKQKGDFPGTYV--------- G_gorilla_ENSGGOP00000015802 M----------------------------------AGPEGFQYRALYPFR-RERPEDLELLPGDVLVVSRAALQALG-VAEGGERCPQSVGWMPGLNERTRQRGDFPGTYV--------- M_domestica_ENSMODP00000002126 M----------------------------------ASAEGFQYRALYQYH-KEREEDLDLLPGDILVVSKGTLEALG-YQDGDEQSPQHIGWILGVNERTKQKGDFPGTYV--------- T_guttata_ENSTGUP00000000409 M----------------------------------GSTDGFQYRALYPYR-KEREEDIDLLPGDILVVSKGALQALG-FKDGDEQTPNQIGWILGVNERTKQKGDFPGTYV--------- T_rubripes_ENSTRUP00000026404 K----------------------------------MAVEGFQYVALHSFT-KDQEEDLDLQPGDLLTVSKASLLSMDNYSEGCEEQPEHLGWLLGYNERTKQRGDFPGTYV--------- D_rerio_ENSDARP00000090206 -----------------------------------MAADGFQYRSIYSYR-KDWEHDIDLEPGDILTVDKGSLLSLG-IKEGDEQHPECIGWILGFNERTKQRGDFPGTYV--------- T_nigroviridis_ENSTNIP00000014006 -----------------------------------MAVEGFQYVALHAFT-KDQEEDLDLQPGDLLTVSKASLVSLDSYSEGCEEQPEHLGWLLGYNERTKQRGDFPGTYV--------- T_rubripes_ENSTRUP00000018794 R----------------------------------MSAEGYQYRALYEYK-KEREEDIDLHVGDILLVSKAALVALG-YGDGMELRPEGIGWLPGFNETTQEKGDFPGTYV--------- T_rubripes_ENSTRUP00000027602 A----------------------------------MSSEGFQYRALYDYK-KEREEDIDLHVGDVLLVSRGALLALG-CSSGAEERPSEIGWLPGFNETTQEKGDFPGTYV--------- A_carolinensis_ENSACAP00000016070 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLRLGDILTVNKGTLVALG-FSDGEEAKPEEIGWLNGYNETTGERGDFPGTYV--------- T_nigroviridis_ENSTNIP00000022063 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDLHVGDVLLVSRGALLALG-CSSGAEERPSEIGWLPGFNETTQEKGDFPGTYV--------- G_aculeatus_ENSGACP00000020473 -----------------------------------MATEGFQYVALHAFT-KDQEEDLDLQPGDLLTVSEASLLSMENYQEGCEQQPELLGWLLGYNERTKQRGDFPGTYV--------- M_mulatta_ENSMMUP00000015140 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- G_gallus_ENSGALP00000023822 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGTLLALG-FNEGEEAKPEEIGWLNGFNETTGERGDFPGTYV--------- D_rerio_ENSDARP00000056212 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHVGDILTVNKGALLALG-YMEGMEERPDEVGWLPGFNETTQEKGDFPGTYV--------- E_caballus_ENSECAP00000017836 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FCDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- M_domestica_ENSMODP00000024566 -----------------------------------MSAEGYQYRALYEYK-KEREEDIDLHVGDVLTVNKGSLVALG-FSEGEEAKPDEIGWLNGYNETTGERGDFPGTYV--------- P_pygmaeus_ENSPPYP00000017341 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- C_familiaris_ENSCAFP00000011322 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDVLTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- G_aculeatus_ENSGACP00000001371 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDLRVGDMLLVSRGALLALG-CVGGAEERPSEIGWLPGVNETTQEKGDFPGTYV--------- O_latipes_ENSORLP00000021829 -----------------------------------MSSEGFQYRALYDYK-KEREEDIDLHVGDMLLVSKGALLALG-CSNGAEERPSEIGWLPGFNETTQEKGDFPGTYV--------- H_sapiens_ENSP00000379855 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- P_troglodytes_ENSPTRP00000029009 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- T_guttata_ENSTGUP00000003114 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGTLLALG-FSEGEEAKPEEIGWLNGFNETTGERGDFPGTYV--------- X_tropicalis_ENSXETP00000046442 -----------------------------------MSAEGYQYRALYPYK-KEREEDIDLRVGDTLTVSRATLLALGCLAEGMEARPEQIGWLNGCNENTGQRGDFPGTYV--------- B_taurus_ENSBTAP00000014594 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEAKPEEIGWLNGYNETTGERGDF-GTYV--------- M_musculus_ENSMUSP00000056774 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEDIGWLNGYNETTGERGDFPGTYV--------- G_aculeatus_ENSGACP00000020881 -----------------------------------MSAEGYQYRALYDYK-KEREEDISLHVGDILLVSKGELVALG-YTDGLEQRPDEIGWLPGFNETTLEKGDFPGTYV--------- G_gallus_ENSGALP00000037576 M----------------------------------ASSEGLQYRALYEYQ-KDRDEDLALSPGDVLTVSRAALLSAPNYKDGDERSPQ--GWLHGLNERTKERGHFPGTYV--------- T_guttata_ENSTGUP00000008408 ------------------------------------SSDGLQYRALYEYQ-KDREEDLALCPGDVLTVSRAGLLGSPNYKDGDERNPQ--GWLHGVNERTKERGDFPGTYV--------- E_caballus_ENSECAP00000007453 M----------------------------------AGAEGFQYRALYRFR--RRPEDLELLPGDVLVVSRAALQALG-VAEGSERCPQSVGWMPGFNERTRQRGDFPGTYV--------- O_cuniculus_ENSOCUP00000004433 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003326 -----------------------------------MSAEAYQYRALYDYK-KEREEDIDLHEGDVLLVSKGALVALG-YTDGLEQQPNKIGWLPGFNETTQEKGDFPGTYV--------- R_norvegicus_ENSRNOP00000025687 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEDIGWLNGYNETTGERGDFPGTYV--------- X_tropicalis_ENSXETP00000007065 -----------------------------------------MYNTVWNMD-Q--DD---------------------------------------------------------------- A_carolinensis_ENSACAP00000015633 -----------------------------------------MYNTVWDMD-R--DD---------------------------------------------------------------- R_norvegicus_ENSRNOP00000000157 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- G_aculeatus_ENSGACP00000006864 -----------------------------------------MYNTVWTTE-QTGEE---------------------------------------------------------------- C_familiaris_ENSCAFP00000006438 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- M_mulatta_ENSMMUP00000040267 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- B_taurus_ENSBTAP00000003878 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001627 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- P_troglodytes_ENSPTRP00000001190 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- H_sapiens_ENSP00000361075 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- M_musculus_ENSMUSP00000030464 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- D_rerio_ENSDARP00000040333 -----------------------------------------MYNTVWNTE-K--ED---------------------------------------------------------------- O_latipes_ENSORLP00000016725 G----------------------------------FSQTKAMYNTVLTTE-KADEE---------------------------------------------------------------- T_rubripes_ENSTRUP00000000305 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009424 -----------------------------------------MYNTVWNMD-R--DD---------------------------------------------------------------- X_tropicalis_ENSXETP00000028313 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012307 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- T_rubripes_ENSTRUP00000030226 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013359 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021319 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009742 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009961 -----------------------------------------MYNTVWSMD-R--DD---------------------------------------------------------------- M_domestica_ENSMODP00000002600 -----------------------------------------MYTPPWGME-RE---------------------------DGGEGEGE--GGEGGESE---------------------- A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089169 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL013596-PA M----------------------------------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000004274 MS-------------------------DQQPIYPHQSVPGIEYRMVADYEPQDKDRCIRCRANDTVIVK----LPLNFAFTGTDKHPE--GWLYCTNLQTDETGYIPAEYV--------- A_gambiae_AGAP005583-PA MTAVNMYDHVEVFKTKAIKGCDLPKLDRDKLEQMGIKNDFHQQSILTTITQLLMSAEMTAAAAAELPIVPAPVNLPVGTDQQQQQQQYNGHNLVNGSFSKQQKCDMCKNYLLGLVHQGLF D_melanogaster_FBpp0077791 MQ---------------------------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022692 -----------------------------------MSSEGYQYRALYDYK-KEREEDIDLHVGDILLVSKAALVALG-YGEGMELRPEGIGWLSGFNETTQEKGDFPGTYV--------- G_gorilla_ENSGGOP00000004170 -----------------------------------MSAEGYQYRALYDYK-KEREEDIDLHLGDILTVNKGSLVALG-FSDGQEARPEEIGWLNGYNETTGERGDFPGTYV--------- C_elegans_Y110A7A.10 MSTT-------------------------------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000990 M--------------------------------------GFGGDLKYSHDALLKLQDWELRLLETVKKF---------MVMRVKSDKEYASTLQNLCNQVDKESACQLDYI--------- R_norvegicus_ENSRNOP00000021758 M--------------------------------------GFGSDLKNSQEAVLKLQDWELRLLETVKKF---------MALRIKSDKEYAYTLQNLCNQVDKDSTVQVNYV--------- 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGA--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDSESHYRPE P_troglodytes_ENSPTRP00000018245 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGA--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDSESHYRPE M_mulatta_ENSMMUP00000004228 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGA--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDSESHYRPE B_taurus_ENSBTAP00000003033 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGP--------------PEPGL-TLPDLPEQFSPPDVAPPILVKLVEAIERTG-LDS---YRPE C_familiaris_ENSCAFP00000022072 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGP--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDSESLYRPE M_musculus_ENSMUSP00000034296 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPLDGS--------------SESGH-ILPDLAEQFSPPDPAPPILVKLVEAIEQAE-LDSECYSKPE R_norvegicus_ENSRNOP00000026210 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPLDGP--------------SESGH-TLASLAEQFSPPEPAPPILVKLIEAIEQAE-LDSECYSRPE P_pygmaeus_ENSPPYP00000010903 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGA--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDSESHYRPE O_anatinus_ENSOANP00000002082 ----------------------------EYVGPVKIALPSHRPWGQRP--LPATPGAGTCHPQESL-------EPAGT-LLPDVSEQFAPPEVAPPILLKLVEAIERKG-LDGEMLYRAS G_gallus_ENSGALP00000005414 ----------------------------EYVGPVKISVPSHRPRVQRP--LPATPGASGCRLQEA--------LEQGS-PLPDLQEQFSPPEVAPPLLVKLVEAIEKKG-LDSEMLYRTS G_gorilla_ENSGGOP00000015802 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGA--------------PEPGL-TLPDLPEQFSPPDVAPPLLVKLVEAIERTG-LDXXXXXXXX M_domestica_ENSMODP00000002126 ----------------------------EYLGPVKIALPSHRPRGHRP--LPATPGRPRDSP-----------EPAGA-LLPDLPEQFVPPEVAPPILQKLVEAIERKG-LDSDALYRPS T_guttata_ENSTGUP00000000409 ----------------------------EYVGPVKIAVPSHRPRGPSP--ELQEPCPGW--------------SSTRS-PLPDLQEQFSPPEIAPPLLVKLVEAIEKKG-LDSEIYACPE T_rubripes_ENSTRUP00000026404 ----------------------------KFVGSMKMALPSIQPRSQRP--LPAAPRPDSSQ--------------PTV-SMPDLSEQFTPPETAPLALVSLIQAIEKRG-TSLSPEGKLV D_rerio_ENSDARP00000090206 ----------------------------QYVGPVKLSAPYCQPRSQRP--LPAVPRPEPTASLQG--------QKSSK-TDLDLTKQFMHPETAPPNLIKLIEAVERSG-LDCRTLYRTS T_nigroviridis_ENSTNIP00000014006 ----------------------------RYVGPMKMAPPSSQPRSQRP--LPAAPRPDPSQGDVE---------RQAV-SMPDLSEQFTPPETAPPTLVSLIQAVEKRG-LESEALYRST T_rubripes_ENSTRUP00000018794 ----------------------------EFVGKKWLSPPTPKPRPLRP--LPLAPADSLLSY------------PPGF-SLPDLTEQFSLPETSPPMLARLLEAIERKG-LDNPTLYRTF T_rubripes_ENSTRUP00000027602 ----------------------------EFIGRKRMSPPTPKPRPPRP------PS-ASARADSE---------SDGF-VLPDLAEQFGPPDTAPPLLTRLMEAIENKG-LDAPVC---- A_carolinensis_ENSACAP00000016070 ----------------------------EYIGRKKISPPTPKPRPVRP--LPVAPSPSRVGTDSD---------QSGF-ALPDLSEQFSSPDNAPPILIKLVEAIERKG-LECSTLYRSQ T_nigroviridis_ENSTNIP00000022063 ----------------------------EFIGRKRMSPPTPKPRPPRP------PS-ASARADSE---------SEGS-LLPDLAEQFGPPDTAPPLLTRLMEAIENRG-LEAPGVYQGL G_aculeatus_ENSGACP00000020473 ----------------------------EYVGPVKMALPASQPRSQRP--LPVAPRPESLQ---------------AV-SALELSEQFTPPETAPPALAGLIQALEKRV-TAANHHSRKK M_mulatta_ENSMMUP00000015140 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKTEADVE---------QQAL-TLPDLAEQFAPPDVAPPLLIKLVEAIEKKG-LECSTLYRTQ G_gallus_ENSGALP00000023822 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPSPSKADAESE---------QQAF-SLPDLTEQFSPPDVAPPILIKIIETIEKKG-LECSTLYVTQ D_rerio_ENSDARP00000056212 ----------------------------EFIGKKKISPPTPKPRPPRP--LPVAPGPTRQDSDSE---------QSLS-TLLDLTEQFAPPEVAPSMLLKLLEAIEKKG-LDNPTLYRNF E_caballus_ENSECAP00000017836 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKTEADSE---------QQAL-TLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LECPTLYRTQ M_domestica_ENSMODP00000024566 ----------------------------EYIGRKRISPPTPKPRPPRP--LPVAPGSSKLETDNE---------QQGF-TLLDLTEQFSSPAVAPPILIKLVEAIEKKG-LECPTLYRTQ P_pygmaeus_ENSPPYP00000017341 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKTEADVE---------QQAL-TLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LECSTLYRTQ C_familiaris_ENSCAFP00000011322 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKAEADCE--------QQQAL-ALPDLAEQFAPPDIAPPLLVKLLEAIEKKG-LECSTLYRTP G_aculeatus_ENSGACP00000001371 ----------------------------EFIGRKRMSPPTPKPRPQRP------GSAASVRMDSE---------SEGF-TMPDLPEQFAPPDSAPPLLTRLMEAIEAKGSLENLDVYRGV O_latipes_ENSORLP00000021829 ----------------------------EFVGRKRISPPTPKPRPPRP------PSAASTRTDSE---------SESF-VLPDLPEQFGPPDTAPPLLSRLMEAVEARG-SERKPLFVTF H_sapiens_ENSP00000379855 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKTEADVE---------QQAL-TLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LECSTLYRTQ P_troglodytes_ENSPTRP00000029009 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPGSSKTEADVE---------QQAL-TLPDLAEQFAPPDIAPPLLIKLVEAIEKKG-LECSTLYRTQ T_guttata_ENSTGUP00000003114 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPSPAKAESESE---------QQAF-SLPDLTEQFTPPDVAPPILVKIVETIEKKG-LEYSTLYGAQ X_tropicalis_ENSXETP00000046442 ----------------------------EYIGRKRISPPTPKPRPPRP--LPVAPGAVRGEAE-----------AQAF-TLPDLTEQFSPPDTAPPVLIKLIEAIEKKG-LESATLYRSQ B_taurus_ENSBTAP00000014594 ----------------------------EYM-REKISPPTPKPRPPRP--LPVAPGPSKTEADSE---------QQAS-TLPDLAEQFAPPDVAPPLLIKLVEAIEKKG-LECSTLYRTQ M_musculus_ENSMUSP00000056774 ----------------------------EYIGRKRISPPTPKPRPPRP--LPVAPGSSKTEADTE---------QQAL-PLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LECSTLYRTQ G_aculeatus_ENSGACP00000020881 ----------------------------EFIGRKRISPPTPKPRPLRP--LPEAPGGFRADTDSD--------SEQGF-CLLDLTEQFSPPETSPPMMARLLEAIEKKG-LDNPTLYRTF G_gallus_ENSGALP00000037576 ----------------------------EYLGP--VCITSTKAKT-RP--LPPPPAGTPVPTGQPWGECGGLGEQHGH-LVAEHAEQPALPEKALLTVARLIEALEKQG-LDSELLYRSD T_guttata_ENSTGUP00000008408 ----------------------------EYLGPTRIAAAATKARP-RP--LPLPPAGTPTPWGLS--------------GQAELTEHPALPEQALQTVARLIEALEKQG-TETH-----G E_caballus_ENSECAP00000007453 ----------------------------EFLGPVALARPGPRPRGPRP--LPARPRDGP--------------PEPGR-GLGGGSGGGVPSDPRFPLLCMLMHCPSSWG-LQTGSPEEPP O_cuniculus_ENSOCUP00000004433 -----------------------------------------------------------------------------S-TLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LECSTLYRTR O_latipes_ENSORLP00000003326 ----------------------------EYIGRKWISPPTPKPRPVRP--LPVAPSPVKTDEESD--------SEQGGSCLPDLTEQFSLPDTAPPMLTRLLEAIEKKG-LENPTLYRTF R_norvegicus_ENSRNOP00000025687 ----------------------------EYIGRKRISPPTPKPRPPRP--LPVAPGSSKTEADTE---------QPVL-TLPDLAEQFAPPDVAPPLLIKLLEAIEKKG-LECSTLYRTQ X_tropicalis_ENSXETP00000007065 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015633 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000157 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006864 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000006438 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040267 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003878 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001190 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000361075 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030464 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000040333 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016725 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000305 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009424 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000028313 ----------------------------------------------------------------------------GT-PLPELVDQFSPPDVAPPVLARLLEAIEKRG-GTKSSKNNIC O_cuniculus_ENSOCUP00000012307 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030226 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013359 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021319 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009742 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009961 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002600 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089169 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL013596-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000004274 ----------------------------EYV-QTVVPRPAPRERPLLP-------------------------------PVPEVVDEAEVPPVIPP------------------------ A_gambiae_AGAP005583-PA CTQCNMVVHRQCSVMGLRPCSAAGTQQQQQSQQQSQQQSQQQSQQQQPTQQVGSTTGGYMLGGAYRQEHQHMFGKSLC-LLFDVQQQAAPQIVVDLCTSLEKKAVMDKG-LDLYVVYRTT D_melanogaster_FBpp0077791 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022692 ----------------------------EFIGKKWISPPTPKPRPLRP--LPLAPSTFRAETDSD--------SEQGS-CLPDLTEQFSLPETCPPMLAKLLEAIEAKG-LDNPTLYRTF G_gorilla_ENSGGOP00000004170 ----------------------------EYIGRKKISPPTPKPRPPRP--LPVAPG-SKTEADVE---------QQAL-TLPDLAEQFAPPDIAPPLLIKLLEAIEKKG-LECSTLYRTQ C_elegans_Y110A7A.10 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000990 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000021758 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 LP----APRT---------DWSLSDVDQWDTAA-LADGIKSFLLALPAPLVTPE---ASAEARRALR----E-AAGP------VGPALEPPTLP-LHRALTLRFLLQHLGRVAS--RAPA P_troglodytes_ENSPTRP00000018245 LP----APRT---------DWSLSDVDQWDTAA-LADGIKSFLLALPAPLVTPE---ASAEARRALR----E-AAGP------VGPALEPPTLP-LHRALTLRFLLQHLGRVAR--RAPA M_mulatta_ENSMMUP00000004228 LP----TPRT---------DWTLSDVDQWDVTA-LADGIKSFLLALPAPLVTPE---ASAEARRALR----E-AAGP------VGPALEPPTLP-LHRALTLRFLLQHLGRVAR--RAPA B_taurus_ENSBTAP00000003033 PP----AVRT---------DWSLSDVEQWDAAA-LSDGVKGFLLALPAPLVTPE---AAAEAHRALR----E-AAGP------VGPALEPPTLP-LHHALTLRFLLQHLGRVAG--RAPA C_familiaris_ENSCAFP00000022072 LP----APRT---------DWSLSDVEQWDAAA-LTDGVKSFLLALPAPLVTPE---AAAEARRALR----E-AAGP------VGPALEPPTLP-LHRALTLRFLLQHLGRVAR--RAPA M_musculus_ENSMUSP00000034296 LP----ATRT---------DWSLSDLEQWDRTA-LYDAVKGFLLALPAAVVTPE---AAAEAYRALR----E-VAGP------VGLVLEPPTLP-LHQALTLRFLLQHLGRVAR--RAPS R_norvegicus_ENSRNOP00000026210 LP----APRT---------DWSLSDLEQWDRTT-LYDAVKGFLLALPAAVVTPE---AASEAYRAMR----E-VTGP------VGLVLEPPTLP-LHQALTLQFLLQHLGRVAR--RAPS P_pygmaeus_ENSPPYP00000010903 LP----APRT---------DWSLSDVDQWDAAA-LADGIKSFLLALPAPLVTPE---ASAEARRALR----E-AA--------------------------------------------- O_anatinus_ENSOANP00000002082 AS----GLRA---------DWTLGDIEQWDVLT-LSETLKSYLQALPGPLVPPS---AHGDLLHALQ----E-APQPETCRKQLLALLEPPGVP-LQNSLALHFLLRHLGKVAQ--QADR G_gallus_ENSGALP00000005414 GSELRQALRT---------DWSLGDLEPFDVHS-LSEALRGYLQDLPSPVVPVS---VHGDILRILQ----E-IPQPENCRKQLLLALESPAIP-LQNTLTLQFLLRHLGKVSQ--QAES G_gorilla_ENSGGOP00000015802 XX----XXXX---------XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXX---XXXXXXXXXX----X-XXXX------XXXXXXXXXXX-XXXXXXXXXXXXXXXXXXX--XXXX M_domestica_ENSMODP00000002126 SEPR--PPKI---------DWTLSDVDQWDVTA-LSEALKGYLQALPRPLVPPG---AHGDILHALQ----G-ESPPS---QQLQVALEPPVVP-LHNALTLRFLLQHLGRVAQRARAQG T_guttata_ENSTGUP00000000409 FL----AEVV---------DWTLGDLEPLDVHS-LGEALRGYLQDLPSPVVPVS---VHGDILRILQ----V-VPAVP------ALSLVRLAVP-LQNTLTLQFLLRHLGKVSH--QAES T_rubripes_ENSTRUP00000026404 SS-----------------GCSESDLGQKDVGF-LSECVLRYLKDIPSPLIPAC---IYPQLQTAVTLKQQALNQAAG----MSKCAFNATTVP-LHHRLTLQYLLTHLAKVTQ--AQAS D_rerio_ENSDARP00000090206 ASDNQRPSLSDINCDMA--ELQDLDVGQWDIHA-LSEAVIRYLQDLPAPIIPPC---VYTDLQAAVQLESGT-DVPSVRRRELLQQVLDKPEVP-LQNLLTLHYLLQHLDKVCQ--SAEQ T_nigroviridis_ENSTNIP00000014006 DSPVPDVPVYS--------LCSESDLGQKDVAY-LSECVLRYLKALPSPLIPAC---IYPQLQTAVGLTQQALNQAAGQDREVSLVIEKATTVP-LHHRLTLQFLLTHLAKVTQ--AQAS T_rubripes_ENSTRUP00000018794 TASGGLE------------DAPSADLDQLELPV-LCDGLHRYLQDLPLPIIPPA---VYPQMVHTAK----E-VVSPEECAQLLRHIASTPSLP-PQYWLTIHCLIRHFSRVCQ--NCTK T_rubripes_ENSTRUP00000027602 -----CDVSLLLNT----GVFVFSDLEQLDLLS-LCCGVLRFLQDLPGPILPSI---LQADMIRAVQ----E-VRDVEDCAQVLRCIASSSSCP-AQYGLTLLSVVRHLARVCL--HGSR A_carolinensis_ENSACAP00000016070 GSSSTNELRQITEC-----DVSTVDFDSVDIQI-LSDALKRYFLDLPNPVIPAS---VYNEMTSIAQ----E-VQNSEEYAQVLKRLIRSPNIP-QQYWLTLQYLLKHFSRLCQ--SSNK T_nigroviridis_ENSTNIP00000022063 SAG-GLDVRQLADAVRSRWDASLTDLEQLDVPS-LCCGVVRFLQDLPGPILPSV---LQADMIRAVQ----E-VRDLEDCAQVLRCVASSSSCP-AQHGLTLLSLVRHLARLCL--HGSR G_aculeatus_ENSGACP00000020473 CG-----------------QTSSSKAGQNFFLWNFSSGIL-----LPFKLLSHCSSRSYSSRQSSLSSFGTDGAVAGSHGREVSLVLESSPSVP-LHHRLTLQYLLTHLAKVTH--LQAS M_mulatta_ENSMMUP00000015140 SSGNLAELRQLLDC-----DTASVDLEMIDVHI-LADAFKRYLLDLPNPVIPAA---VYSEMISLAQ----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK G_gallus_ENSGALP00000023822 SSSSSAELRQILEC-----DASSLDLETFDVHT-LSDALKRYLLDLPNPIIPAT---VYSDIISVAQ----D-VQSSEEYAQLLKKLIRSPNIP-HQYWLTLQYLLKHFLRLCQ--ASSK D_rerio_ENSDARP00000056212 TAGGGLDVRQCFDS-----DPASVDLEQMDLQM-LCDGLRRYLQDLPQPVIPPV---IYNEMIRIAQ----E-VQGTDECAQHLRLVASSTALP-PQYWLTLQSLLRHFSHVCQ--SSAV E_caballus_ENSECAP00000017836 SSSNLAELRQLLDC-----DAASLDLEMIDVQV-LADAFKRYLLDLPNPVIPVA---VYSEMISLAP----E-VQSSEEYIQLLKKLIRSPNIP-HQYWLTLQYLLKHFFKLTQ--TSSK M_domestica_ENSMODP00000024566 SSSSLAELRQLLDC-----DASSVDLDVIDVQV-LSDAFKRYLLDLPNPVIPGT---IYSEMISVAQ----E-LQNSEENVQMLKKLMRTPHIP-HQHGLTLQYLLKHFFKLCQ--ASSK P_pygmaeus_ENSPPYP00000017341 SSSNLAELRQLLDC-----DTASVDLEMIDVHV-LADAFKRYLLDLPNPVIPAA---VYSEMISLAQ----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK C_familiaris_ENSCAFP00000011322 SSSNPAELRQLLDC-----DAASTDLEMIDVQV-LGDAFKRYLMDLPNPVIPVA---VYNEMIYLAQ----E-VQSSEEYIQLLKKLIRAPTIP-HQYWLTLQYLLKHFFKLSQ--TSSK G_aculeatus_ENSGACP00000001371 TGG-GLDTRELADA-EYVGVRLFSDLEQLEVSS-LCDGVIRFLQDLPGPVLPSS---LQTDMIHAVQ----E-VRDLEECAQLLRSVASSPSFP-AQYGLTLLSVVRHLARLCL--YGSR O_latipes_ENSORLP00000021829 SVC-GEGEGKTAGL-RLTDVRLFSDLEQLEVPS-LCDGVIRFLLDLPGPVLPPQ---LQGEMVHAVQ----EAVKTSCPTAQVLRAVASSAACP-AQYGLTLLSVVRHLARLCL--HATR H_sapiens_ENSP00000379855 SSSNLAELRQLLDC-----DTPSVDLEMIDVHV-LADAFKRYLLDLPNPVIPAA---VYSEMISLAP----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK P_troglodytes_ENSPTRP00000029009 SSSNLAELRQLLDC-----DTPSVDLEMIDVHV-LADAFKRYLLDLPNPVIPAA---VYSEMISLAP----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK T_guttata_ENSTGUP00000003114 GSSSAVELRQIFEC-----DTSSLDLETFDVHT-LSDALKRYILDLPNPIIPAA---VYSDMISLAQ----E-VQSSEEYAQLLKKLIRSPNIP-PQYWLTLQYLLKHFLRVCQ--ASSK X_tropicalis_ENSXETP00000046442 SSSSLTELRQILEC-----DAASVDFEQFDISI-LSDALKRYLLDLPNPVIPAL---MYSEMLSAAR----E-SISSDEYVQLLRKTIRCANVP-QQYWLTLQYLLKHFLQLCQ--SSSK B_taurus_ENSBTAP00000014594 SSSNPAELRQLLDC-----DTASLDLEMFDVHV-LADAFKRYLLDLPNPVIPVA---VSSELISLAP----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK M_musculus_ENSMUSP00000056774 SSSNPAELRQLLDC-----DAASVDLEMIDVHV-LADAFKRYLADLPNPVIPVA---VYNEMMSLAQ----E-LQSPEDCIQLLKKLIRLPNIP-HQCWLTLQYLLKHFFKLSQ--ASSK G_aculeatus_ENSGACP00000020881 TAGGGLEVRQFYDC-----DPASPDLDQVELPV-LCDGLRRYLQDLPQPVIPAA---LHPQMVHTAK----E-VGNPEECAQLLRRVGSTPSLP-PQYWLTLHCLLRHFSRVCL--NSSK G_gallus_ENSGALP00000037576 PGVLGDAELKE----ALLADASDVDMELYDAQT-LAETLKWYLQELPAPLVPPT---LCADLLCIAQ----E-TLSVEECGQRAQALLAPPALP-QPHTLLLQELIRHFGHLCQ--AACK T_guttata_ENSTGUP00000008408 PGCTRSHQLCPVPCVSLPADASAVDMDLYEAQT-LADALKWYLQELPTPLIPPA---LYSDLVHMAQ-----ETPGLEECGQRARALLAPPALP-QPQALLLRQLARHFCHLCQ--GSPR E_caballus_ENSECAP00000007453 FFQK---------------EGSHPKLKRWELQA-TARGAKGHLPPLPGLRWPPG---------------QALPSKSARALCHQLGPALARPQFPHLEHLETGRVLLCLQALPLR--APET O_cuniculus_ENSOCUP00000004433 SSSNPAELRQLL-------CAASVDLEAMDVQV-LADAFKRYLLDLPNPVIPVA---VYSEMLSLAQ----E-IQSAEEYTQVLKKLIRSPNIP-HQYWLTLQYLLKHFFRLSQ--ASSK O_latipes_ENSORLP00000003326 TAGAGLEVRQYFES-----DPPSADLDQLDLPV-LCDGLRRYLLDLPQPVVHPA---LQVQMVHTAK----AEVANPEECAQLLRRVASTPSLP-HQYWLALHCLLRHFARVCQ--SGSK R_norvegicus_ENSRNOP00000025687 SSSNPAELRQLLDC-----DAASVDLDVFDVHV-LADAFKRYLADLPNPVIPVA---VYNEMMSLAQ----E-VPSSEDYIQLLKKLIRSPNIP-HQYWLTLQYLLKHFFKLSQ--ASSK X_tropicalis_ENSXETP00000007065 --------------------------------------------------------------------------------------------------------------------ADWR A_carolinensis_ENSACAP00000015633 --------------------------------------------------------------------------------------------------------------------TDWR R_norvegicus_ENSRNOP00000000157 --------------------------------------------------------------------------------------------------------------------ADWR G_aculeatus_ENSGACP00000006864 --------------------------------------------------------------------------------------------------------------------GDWR C_familiaris_ENSCAFP00000006438 --------------------------------------------------------------------------------------------------------------------ADWR M_mulatta_ENSMMUP00000040267 --------------------------------------------------------------------------------------------------------------------ADWR B_taurus_ENSBTAP00000003878 --------------------------------------------------------------------------------------------------------------------ADWR P_pygmaeus_ENSPPYP00000001627 --------------------------------------------------------------------------------------------------------------------ADWR P_troglodytes_ENSPTRP00000001190 --------------------------------------------------------------------------------------------------------------------ADWR H_sapiens_ENSP00000361075 --------------------------------------------------------------------------------------------------------------------ADWR M_musculus_ENSMUSP00000030464 --------------------------------------------------------------------------------------------------------------------ADWR D_rerio_ENSDARP00000040333 --------------------------------------------------------------------------------------------------------------------DDWR O_latipes_ENSORLP00000016725 --------------------------------------------------------------------------------------------------------------------GDWR T_rubripes_ENSTRUP00000000305 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009424 --------------------------------------------------------------------------------------------------------------------ADWR X_tropicalis_ENSXETP00000028313 LCLPHI-------------DLSSVELEATDVHS-LAEAVMVFLQELPSPVIPVQ---VHQEIIQALL----------EQKRMQISLIIQPPVVP-LHHVLTFQHILRHIVNMCS----ES O_cuniculus_ENSOCUP00000012307 --------------------------------------------------------------------------------------------------------------------ADWR T_rubripes_ENSTRUP00000030226 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013359 ----------------------------------------------------------------------------------------------------TVNLIFNRKKRQTATWTSYV G_aculeatus_ENSGACP00000021319 --------------------------------------------------------------------------------------------------------------RQDDVTNSPL T_nigroviridis_ENSTNIP00000009742 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009961 --------------------------------------------------------------------------------------------------------------------ADWR M_domestica_ENSMODP00000002600 -------------------DWRDVTM----------------------------------------------------------------------PYS---TELIFYI----------- A_carolinensis_ENSACAP00000012532 ---------------------------------------------------------------------------------------------------LTLRFLLRHLATVAT--HAQS T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089169 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL013596-PA -----------------------------------------------------------------------------------------------VSWLISFFELYFDLIVGLTIVYDGI C_intestinalis_ENSCINP00000004274 ------------------------------------------------------------------------------RCGSDSRPQVNSNYVP-VPINVNV--------------SNGS A_gambiae_AGAP005583-PA PLRYDEVNKLRDALNE---NLLNIDLNGYTPEC-VATVLKKFFHELPDPLIPVA---WYQSFIDASL---------LDDQQAVERMKGIIQEMA-PHHNKTLQYFMRHLIRICRLQFMRG D_melanogaster_FBpp0077791 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022692 TAGGGLEVRQYIEN-----DAPSTELDQFELPV-LCDGLRRYLQDLPLPAIPPA---LYPQMIHTAK----E-VVNPEECAQLLRHIASTPSLP-PQYWLTIHCLIRHFSKVCQ--NCTK G_gorilla_ENSGGOP00000004170 SSSNLAELRQLLDC-----XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXIPAA---VYSEMISLAP----E-VQSSEEYIQLLKKLIRSPSIP-HQYWLTLQYLLKHFFKLSQ--TSSK C_elegans_Y110A7A.10 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000990 ------------------SNVSKSWLLVVQQTEQLSKIMKTHAEDL-----------------------------NSGPLHRLTMMIKDKQQVK-KSFVGVHQQIEAEMYKVTKTELEKL R_norvegicus_ENSRNOP00000021758 ------------------SNVSKSWLLMIQQTEQLSRIMKTHAEDL-----------------------------NSGPLHRLTMMIKDKQQVK-KSYVGIHQQIEAEMIKVTKTELEKL 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 LGPAVRALGATFGPLLLRA----PPPPSSPPPGGAPDG--SEP--------SPDFPALLVEKLLQEHLEEQEVAPP----ALP-PK---------------------------PPK---- P_troglodytes_ENSPTRP00000018245 LGPAVRALGATFGPLLLRA----PPPPSSPPPGGAPDG--SEP--------SPDFPALLVEKLLQEHLEEQEVAPP----ALP-PK---------------------------PPK---- M_mulatta_ENSMMUP00000004228 LGPAVRALGATFGPLLLRA-----PPPSSPPPGGAPDG--SEP--------SPDFPALLVEKLLQEHLEEQEVAPP----ALP-PK---------------------------PPK---- B_taurus_ENSBTAP00000003033 PGPAVRALGATFGPLLLRA-----PPPPSPPPGGAPDG--TEP--------TPDFPALLVEKLLQEHLEEQEVAPP----ALP-PK---------------------------PPK---- C_familiaris_ENSCAFP00000022072 PGPAVRALGATFGPLLLRA------PPPSPPPGGAPDG--TEP--------SPDFPVLLVEKLLQEHLEEQEVTPP----ALP-PK---------------------------PPK---- M_musculus_ENSMUSP00000034296 PDTAVHALASAFGPLLLRI----------PPSGGEGDG--SEP--------VPDFPVLLLERLVQEHVEEQDAAPP----ALP-PK---------------------------PSK---- R_norvegicus_ENSRNOP00000026210 PATAVHALASAFGPLLLRA----------PPPGGEGDG--SEP--------APDFPVLLLERLVQEHVDEQDTAPP----ALP-PK---------------------------PSK---- P_pygmaeus_ENSPPYP00000010903 ----------------------------------------SEP--------SPDFPALLVEKLLQEHLEEQEVAPP----ALP-PK---------------------------PPK---- O_anatinus_ENSOANP00000002082 NGLSPRVLGEIFGPLLLRLPISGSPPAPPPPPQPRGSK--AES--------TTDFSVLLLETLLQDQDEEQEPAPP----ALP-PK---------------------------PSK---- G_gallus_ENSGALP00000005414 NSLHPQALGEIFGPLLLRL------------PGAS-----PEL--------SPDFSVLFLEMLLQTKELEPEQLPP----ALP-PK---------------------------PPK---- G_gorilla_ENSGGOP00000015802 XXXXXXXXXXXXXXXXXXX----XXXXXXXXXXXXXXX--XXX--------XXXXXXXXXXXXXXXXXXXXXXXXX----XLP-PK---------------------------PPK---- M_domestica_ENSMODP00000002126 SGLGPQALGEIFGPLLLRLPATGSGGPPPPR---------TEQ--------SPDFSALFLEMLLQDQEEEQEPPPP----ALP-PK---------------------------PPK---- T_guttata_ENSTGUP00000000409 NSLHPRALGELFGPLLLRL------------PGARGRG--SSD--------IPDFSVLFLETLLQTKELEPEQLPP----ALP-PK---------------------------PPK---- T_rubripes_ENSTRUP00000026404 NSLDAQTLGQIFGPLLIRT-----------SASTHWCRKIYSSNIPNETSLDEDFAGLVVEKLLKERTTERDITPP----VLP-AK---------------------------PAK---- D_rerio_ENSDARP00000090206 NGLDIYTLGQIFGPLLFRG-----------PVSG------SEE--------DEAFPAAAVERLLLERIWEQEPTPP----ALP-PK---------------------------PPK---- T_nigroviridis_ENSTNIP00000014006 NGLDAQTLGQIFGPLLVWS-----------STSAHW------------TPLDEGFAETVVEKLLTERTTEQDVTPP----VLP-AK---------------------------PAK---- T_rubripes_ENSTRUP00000018794 NLLSARAVGEIFSPMVFRQ-----------QSA-------SSSVPVHSCEPSLDCHIKIIEVLVTSE-MSENQAAP--VAALP-PK---------------------------PPK---- T_rubripes_ENSTRUP00000027602 NQLSPRTLAESFSPVLFRL-----------SAGSFPQPYRSES--------SLDPLVQVLEILITSE-LNMNQAAPVFSPALP-PK---------------------------PVK---C A_carolinensis_ENSACAP00000016070 NLLNARSLAEIFSLLLFRC-----------PVA-------SSD--------NTEHHIKILEVLITSE-WNERQPAP----ALP-PK---------------------------PPK---- T_nigroviridis_ENSTNIP00000022063 NQLSPRSLAESFSPVLFRH-----------SSG-------SES--------SLDLLVQVLEVLITSE-LNMNQAAP-FPSALP-PK---------------------------PVK---C G_aculeatus_ENSGACP00000020473 NGLDTHTLGKIFGPLLIRT-----------GPSTPW------------LSGDDELPALVVERLLIERTTEQDLAPP----VLP-AK---------------------------PVK---- M_mulatta_ENSMMUP00000015140 NLLNARVLSEIFSPMLFRF-----------SAA-------SSD--------NTENLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- G_gallus_ENSGALP00000023822 NLLNARSLAEIFSPLLFKF-----------QIA-------SSD--------NAEHHIRILEILITSE-WNERQPVP----ALP-PK---------------------------PPK---- D_rerio_ENSDARP00000056212 NLLSARALAEIFSPALFRH-----------QPTS------CEP--------SPEAHIRIIEVLVTSE-WSDSQAAP----ALP-PK---------------------------PPK---- E_caballus_ENSECAP00000017836 NLLNARVLSELFSPLLFRF-----------PAA-------SSE--------NSEHLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- M_domestica_ENSMODP00000024566 NLLNARSLSEIFSPVLFRF-----------PNT-------GSD--------NAEHLIKTIELLISSE-WNERQPAP----ALP-PK---------------------------PPK---- P_pygmaeus_ENSPPYP00000017341 NLLNARVLSEIFSPMLFRF-----------SAA-------SSD--------NTENLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- C_familiaris_ENSCAFP00000011322 NLLSARVLSELFSPLLFRF-----------PAA-------SSE--------NTEHLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- G_aculeatus_ENSGACP00000001371 TQLSPRSLAETFSPFLFRP-----------PAG-------FEP--------SLDPLVQVLEVLITSE-LNMVQAAP----ALP-PK---------------------------PIK---S O_latipes_ENSORLP00000021829 NQLSPRMLGELFSPLLFRL-----------AAG-------SES--------GPDPLVQVLEVLITSE-LNMNQAAP----ALP-PK---------------------------PPK---T H_sapiens_ENSP00000379855 NLLNARVLSEIFSPMLFRF-----------SAA-------SSD--------NTENLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- P_troglodytes_ENSPTRP00000029009 NLLNARVLSEIFSPMLFRF-----------SAA-------SSD--------NTENLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- T_guttata_ENSTGUP00000003114 NLLNARSLAEIFSPLLFKF-----------QIA-------SSD--------NTEHHIKILEVLITSE-WNERQPVP----ALP-PK---------------------------PPK---- X_tropicalis_ENSXETP00000046442 NLLSAKSLAEIFSPLLFRI-----------QVS-------SSD--------SSEFSTQILEVLIASE-WNEKQAAP----ALP-PK---------------------------PPK---- B_taurus_ENSBTAP00000014594 NLLNARVLSELFSPLLFRF-----------PAA-------SSE--------NTEHLIKIIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- M_musculus_ENSMUSP00000056774 NLLNARVLSEIFSPVLFRF-----------PAA-------SSD--------NTEHLIKAIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- G_aculeatus_ENSGACP00000020881 NLLSARALGEIFSAVLFRQ-----------QAS-------RWV--------QTDRHIKIIEVLVMSE-CSESQAAP----ALP-PK---------------------------PPKPAPA G_gallus_ENSGALP00000037576 NRLSAQLLGELFGELLLRP-----------APS-------STE-------ASPELCARIIESLIVASEAAEVPAAP----ALP-PK---------------------------PSK---P T_guttata_ENSTGUP00000008408 SRLSPRLLGELFGELLLRP-----------VTA-------RTD--------SHTQYVQGCEAGIASDPDFEAASPS----TLP-PK---------------------------PSK---P E_caballus_ENSECAP00000007453 SRRAAAASATSLGPDPVSP---------------------GPLPGCAPRRRSPLSEPQFLVCKMGPPELSFRTAAP----HQPEPR---------------------------PPP---- O_cuniculus_ENSOCUP00000004433 SLLTARALAEIFSPMLFRF-----------PAA-------SPD--------YREHLVKVIEXXXXXX-XXXXXXXX----XLP-PK---------------------------PPK---- O_latipes_ENSORLP00000003326 NLLSPRTLGEIFSPVFFRQ-----------QSVG------CEP--------SLDAYIKIIEVLVTTE-WSESRAAPEFLFSPP-PT---------------------------PP----- R_norvegicus_ENSRNOP00000025687 NLLNARALSEIFSHVLFRF-----------PAA-------SSD--------NTEHLIKAVELLISTE-WSERQPAP----G----K---------------------------GLQ---- X_tropicalis_ENSXETP00000007065 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----VLP-PK---------------------------PPK---S A_carolinensis_ENSACAP00000015633 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PSK---P R_norvegicus_ENSRNOP00000000157 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P G_aculeatus_ENSGACP00000006864 DVVMPYSTELIF--------------------------------------------------------YLEMDQPP----ALP-PK---------------------------PAK---P C_familiaris_ENSCAFP00000006438 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P M_mulatta_ENSMMUP00000040267 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P B_taurus_ENSBTAP00000003878 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P P_pygmaeus_ENSPPYP00000001627 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P P_troglodytes_ENSPTRP00000001190 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P H_sapiens_ENSP00000361075 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P M_musculus_ENSMUSP00000030464 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P D_rerio_ENSDARP00000040333 DVMMPYSTELIF--------------------------------------------------------YIEMDQPP----ALP-PK---------------------------PTK---P O_latipes_ENSORLP00000016725 DMTMPYSTELIF--------------------------------------------------------YLEMDQPP----ALP-PK---------------------------PAK---S T_rubripes_ENSTRUP00000000305 -----------F--------------------------------------------------------CFSFS-RP----ALP-PK---------------------------PMR---P O_anatinus_ENSOANP00000009424 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P X_tropicalis_ENSXETP00000028313 SGLTHKMAAEIFGPLLLRP-----------VITG------KPAYIQHKAEALPDFPVLLLELLLQDRGLQNDQPPP----ALP-PK---------------------------PTK---- O_cuniculus_ENSOCUP00000012307 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----XXX-XX---------------------------XXX---X T_rubripes_ENSTRUP00000030226 --DYYFDSGMVYPSEGLFY-------------------------------------------------IEMDQAPP----ALP-PR---------------------------SNK---Q O_latipes_ENSORLP00000013359 KQEW--XXXXVYPSEGLFY-------------------------------------------------IEMDQAPP----A-S-SR---------------------------SSK---P G_aculeatus_ENSGACP00000021319 KSLYFRDEGMVYPSEGLFY-------------------------------------------------IEMDQAPP----ALP-PR---------------------------STK---P T_nigroviridis_ENSTNIP00000009742 --DYYFDTGMVYPPEGLFY-------------------------------------------------IEMDQAPP----ALP-PR---------------------------SNK---Q G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009961 EVMMPYSTELIF--------------------------------------------------------YIEMD-PP----ALP-PK---------------------------PPK---P M_domestica_ENSMODP00000002600 ----------------------------------------------------------------------EMD-PP----ALP-PK---------------------------PPK---S A_carolinensis_ENSACAP00000012532 NGLCPRTLGEIFGPLLLRG-----------APSARWVRGPAES--------VADFPAVFLQTLLQNKDPETDLPAP----ALP-PK---------------------------PPK---- T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089169 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL013596-PA DYTN-------------------------------------NWTNKTQIVYNTENHLRIMELLFYKLDWNEKLPEFASAPAVP-PRKISRSTASLQQQQQPQSSQQQPFLQPIPGSSTSA C_intestinalis_ENSCINP00000004274 NS----------------------------------------------------------------------------------PR---------------------------PHR---- A_gambiae_AGAP005583-PA NKQQPTMLLQNWCHILMRP----------------------AWERIVHFVANIKNHLRVLELLMYKIDWNEALPEFLSIPAVP-PRKTSRTGSGAGTG---------------PGST--- D_melanogaster_FBpp0077791 -------------------------------------------------------------------------PSPLHYSTMR-PQA--------------------------PGS---- T_nigroviridis_ENSTNIP00000022692 NLLSARALGEIFSPVFFRQ-----------QSTS--------------CEPSLEAHIKIIEVLVTSEMS-ENQAAP-------------------------------------------- G_gorilla_ENSGGOP00000004170 NLLNARVLSEIFSPMLFRF-----------SAA-------SSD--------NTENLIKVIEILISTE-WNERQPAP----ALP-PK---------------------------PPK---- C_elegans_Y110A7A.10 -----------------------------------------------------------------------------------------------------------------PGT---- T_guttata_ENSTGUP00000000990 KSSYRQLIKEV------------------------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000021758 KSSYRQLIKEM------------------------------------------------------------------------------------------------------------- 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 AK---PA-------STVL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD P_troglodytes_ENSPTRP00000018245 AK---PA-------PTVL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD M_mulatta_ENSMMUP00000004228 AK---LA-------PAGL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD B_taurus_ENSBTAP00000003033 TK---PA-------PTGL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD C_familiaris_ENSCAFP00000022072 AK---PA-------PAGL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD M_musculus_ENSMUSP00000034296 AK---PA-------PTAL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNERLRDTPDGTFLVRD R_norvegicus_ENSRNOP00000026210 VK---PA-------PTAL--------------------------------------------------ANG-GSTPSLQDAEWYWG---DIS--------REEVNERLRDTPDGTFLVRD P_pygmaeus_ENSPPYP00000010903 AK---PA-------PTGL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD O_anatinus_ENSOANP00000002082 PK---AS-------ANNM--------------------------------------------------PT--GNGPTLQESEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD G_gallus_ENSGALP00000005414 PK---PS-------AASL--------------------------------------------------AN--GNSVPLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD G_gorilla_ENSGGOP00000015802 AK---PA-------PTVL--------------------------------------------------ANG-GSPPSLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD M_domestica_ENSMODP00000002126 PK---VQ-------AGSL--------------------------------------------------SN--GSSAPLQEAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD T_guttata_ENSTGUP00000000409 PK---PS-------AASL--------------------------------------------------AN--GNNAPLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD T_rubripes_ENSTRUP00000026404 SK---VA-------PSAM--------------------------------------------------T---DTSSLLTDAEWYWG---EIS--------REEVNEKLRDTPDGTFLVRD D_rerio_ENSDARP00000090206 AK---AM-------ASSV--------------------------------------------------TN--GSDSLLSEAEWYWG---DIS--------REEVNEKMRDTPDGTFLVRD T_nigroviridis_ENSTNIP00000014006 SK---VA-------PSAM--------------------------------------------------T---DTSSLLNDAEWYWG---EIS--------REEVNEKLRDTPDGTFLVRD T_rubripes_ENSTRUP00000018794 PT---PV-------TNNG--------------------------------------------------M---NNNMALQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD T_rubripes_ENSTRUP00000027602 ST---PA-------PPSS--------------------------------------------------F---NNSISLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD A_carolinensis_ENSACAP00000016070 PN---TV-------TNNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD T_nigroviridis_ENSTNIP00000022063 ST---PA-------PPSS--------------------------------------------------F---NNSISLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD G_aculeatus_ENSGACP00000020473 SQ---LA-------PLAM--------------------------------------------------A---DTSSLNDAAEWYWG---EIS--------REEVNEKLRDTPDGTFLVRD M_mulatta_ENSMMUP00000015140 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD G_gallus_ENSGALP00000023822 PN---TV-------TNNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD D_rerio_ENSDARP00000056212 PT---SV-------ANNG--------------------------------------------------M---NNNMALQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD E_caballus_ENSECAP00000017836 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD M_domestica_ENSMODP00000024566 PT---TVT------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD P_pygmaeus_ENSPPYP00000017341 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD C_familiaris_ENSCAFP00000011322 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD G_aculeatus_ENSGACP00000001371 SS---PA-------ASCS--------------------------------------------------F---NNSISLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD O_latipes_ENSORLP00000021829 PT---PA-------ASSS--------------------------------------------------F---NNSMALQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD H_sapiens_ENSP00000379855 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD P_troglodytes_ENSPTRP00000029009 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD T_guttata_ENSTGUP00000003114 PN---TV-------TNNS--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD X_tropicalis_ENSXETP00000046442 ST---AV-------TNNG--------------------------------------------------T---NHIMSLQDAEWYWG---DIS--------REEVNEKLRDTTDGTFLVRD B_taurus_ENSBTAP00000014594 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD M_musculus_ENSMUSP00000056774 PT---TV-------ANNS--------------------------------------------------M---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD G_aculeatus_ENSGACP00000020881 PA---PA-------TNNG--------------------------------------------------M---NNNMALQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD G_gallus_ENSGALP00000037576 MT---PV-------NTNG--------------------------------------------------IKD-NSSFSLQEAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD T_guttata_ENSTGUP00000008408 MT---PV-------NTNG--------------------------------------------------IKD-NSNFSLQEAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD E_caballus_ENSECAP00000007453 LS---PA-------GPGLP-------------------------------------------------LPCARASLPGARAHPRWR---GEA--------AERLNTKSPDDAIGHFLRRV O_cuniculus_ENSOCUP00000004433 PT---TV-------ANNG--------------------------------------------------T---NNNMSLQDAEWYWG---DIS--------REEVNEKLRDTADGTFLVRD O_latipes_ENSORLP00000003326 PS---TA-------RSAC--------------------------------------------------A---ASSGRSHDTRWEGGAEQESS--------SAEEEERKREEGDASGFRLR R_norvegicus_ENSRNOP00000025687 HL---TF-------TSGS--------------------------------------------------A---FLDLEM----WFLS---SLE--------STQVSGV--TAVDSNMLIYG X_tropicalis_ENSXETP00000007065 MT---SL-------STDG--------------------------------------------------SK--ENSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD A_carolinensis_ENSACAP00000015633 IT---PI-------NTNG--------------------------------------------------LKE-NCILSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD R_norvegicus_ENSRNOP00000000157 VT---SA-------VTNG--------------------------------------------------MK--DCFVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD G_aculeatus_ENSGACP00000006864 QQ---PCSVGTGGGSGNG--------------------------------------------------TKDGGAGGSLQEAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD C_familiaris_ENSCAFP00000006438 MT---SA-------ITNG--------------------------------------------------MK--DSSISLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD M_mulatta_ENSMMUP00000040267 MT---SA-------VTNG--------------------------------------------------MK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD B_taurus_ENSBTAP00000003878 MT---SA-------ITNG--------------------------------------------------IK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD P_pygmaeus_ENSPPYP00000001627 MT---SA-------VPNG--------------------------------------------------MK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD P_troglodytes_ENSPTRP00000001190 MT---SA-------VPNG--------------------------------------------------MK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD H_sapiens_ENSP00000361075 MT---SA-------VPNG--------------------------------------------------MK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD M_musculus_ENSMUSP00000030464 MT---PA-------VTNG--------------------------------------------------MK--DSFISLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD D_rerio_ENSDARP00000040333 MT---PV-------NGNG--------------------------------------------------VKE-AASGSLQEAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD O_latipes_ENSORLP00000016725 QQ---SSSVGV---GGGS--------------------------------------------------TTT-KDGGALQEAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD T_rubripes_ENSTRUP00000000305 QQ---PSSEG----VGGG--------------------------------------------------TK--DGAGSLQEAEWYWG---DIS--------REEVNDKLRDTPDGTFLVRD O_anatinus_ENSOANP00000009424 MT---PS-------STNE--------------------------------------------------VKD-SSGVALQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD X_tropicalis_ENSXETP00000028313 PK---PP-------MVTA--------------------------------------------------S---GGGGTLQEAEWYWG---DIS--------REEVNDKLRDTPDGTFLVRD O_cuniculus_ENSOCUP00000012307 XX---XX-------XXXX--------------------------------------------------XX--XXXXXXXXXXXXXX---XXX--------XXXXXXXXXXXXXXXXXXXX T_rubripes_ENSTRUP00000030226 VS---PT-------TNNN--------------------------------------------------CHL-PPPYSLQDAEWYWG---DIS--------RDEVNEKLRDKPDGSFMVRD O_latipes_ENSORLP00000013359 VM---SG-------MNNN--------------------------------------------------CLS-LPVHSLLDAEWYWG---DIT--------RDEVNEKLRDTPDGSFLVRD G_aculeatus_ENSGACP00000021319 AS---ST-------TNNN--------------------------------------------------CLS-PPTHSLQDAKWYWG---DIT--------RDEVNEKLRDTPDGSFMVRD T_nigroviridis_ENSTNIP00000009742 GSSAMSN-------NNNN--------------------------------------------------CLL-PPAYSLQDAEWYWG---DIS--------RDEVNEKLRDKPDGSFMVRD G_aculeatus_ENSGACP00000010853 -----------------------------------------------------------------------------LSDAEWYWG---STS--------REEVNEMMRNTPDGTFLVRD T_rubripes_ENSTRUP00000017331 ----------------------------------------------------------------------------NLSDVEWYWG---SIS--------REEVNSMMRNTPDGTFLVRD T_nigroviridis_ENSTNIP00000013096 --------------ASDS-----------------------------------------------------SSEDDCLSDAEWYWG---SLS--------REEVNNMMRNTPDGTFLVRD G_gorilla_ENSGGOP00000009961 MT---SA-------VPNG--------------------------------------------------MK--DSSVSLQDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD M_domestica_ENSMODP00000002600 LT---QA-------GANG--------------------------------------------------AKD-SSGFSLPDAEWYWG---DIS--------REEVNDKLRDMPDGTFLVRD A_carolinensis_ENSACAP00000012532 PK---PV-------AGPL--------------------------------------------------PNG-GNGTPLQDAEWYWG---DIS--------REEVNEKLRDTPDGTFLVRD T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------RSTTTGSFLTPD D_rerio_ENSDARP00000089169 -----------------------------------------------------------------------------LQDAEWYWA---DIS--------REEVNEILHGMPDGAFLVRD A_aegypti_AAEL013596-PA AAYQSSSSSSGSLRKQPTITSPAAVIPSTLMVGPIYDTGSSGYGSCGSGSTAGDAR-----GTAMFRMVGDADTPADLRAAEWYWG---NIN--------RDEVKEKMTDVPDGSFLVRD C_intestinalis_ENSCINP00000004274 -----P------------------------------------------------------------------SLSQSLQDQEWYWG---SVT--------REEVNAQLSDEQDGTFLVRN A_gambiae_AGAP005583-PA --------------KKSIIASPEGGSIGGPLLESDYSTTTTGSGSSGNTLGRSAAQQYPNGGGMLMSLITDPNTPQELRDAEWYWG---KIS--------RDVAKEKMMDAPDGSFLVRD D_melanogaster_FBpp0077791 --------------------------------------------------------------------LVDPNE-DELRMAPWYWG---RIS--------REEAKSILHGKPDGSFLVRD T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 PT---TV-------ANNG--------------------------------------------------M---NNNMSLQDAEWYWG---DISXXXXXXXXXXXXXXXXXXXXXXXXXXXX C_elegans_Y110A7A.10 ----------------------------------------------------------------------PHGVTHSLMEQGWYWA---DAD--------RSAVSKALSDQPDGSFIVRN T_guttata_ENSTGUP00000000990 -----------------------------------------------------------------------------NSAKEKYKE---AVA--------KGKETEKAKDRCEKATMKLH R_norvegicus_ENSRNOP00000021758 -----------------------------------------------------------------------------NSAKEKYKE---ALA--------KGKETEKAKERCDKATMKLH 610 620 630 640 650 660 670 680 690 700 710 720 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLINHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- P_troglodytes_ENSPTRP00000018245 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLINHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- M_mulatta_ENSMMUP00000004228 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLINHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- B_taurus_ENSBTAP00000003033 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLITHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- C_familiaris_ENSCAFP00000022072 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLITHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- M_musculus_ENSMUSP00000034296 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------ELISHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- R_norvegicus_ENSRNOP00000026210 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------ELISHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- P_pygmaeus_ENSPPYP00000010903 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLINHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- O_anatinus_ENSOANP00000002082 ASSKIQGEYTLTLR-KG---GNNKLIKIFHRDGQYGF-SEPLTFGSVV--------------------------DLITYYRHESLA--------QYNAKLDTRL---LYPVSKH-QQ--- G_gallus_ENSGALP00000005414 ASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFGSVV--------------------------ELITHYRHESLA--------QYNAKLDTRL---LYPISKY-QQ--- G_gorilla_ENSGGOP00000015802 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGHYGF-SEPLTFCSVV--------------------------DLINHYRHESLA--------QYNAKLDTRL---LYPVSKY-QQ--- M_domestica_ENSMODP00000002126 ASSKIQGEYTLTLR-KG---GNNKLIKVFHRDGQYGF-SEPLTFSSVV--------------------------ELITHYRHESLA--------QYNAKLDTRL---LYPVSKH-QQ--- T_guttata_ENSTGUP00000000409 ASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFGSVV--------------------------ELITHYRHESLA--------QYNAKLDTRL---LYPISKY-QQ--- T_rubripes_ENSTRUP00000026404 ASSKLEGEYTLTLR-KG---GNNKLIKIYHREARYGF-SEPLTFLTVV--------------------------ELINHYRHESLA--------QYNAKLDTKL---LYPVSKY-QQ--- D_rerio_ENSDARP00000090206 ASSKVHGEYTLTLR-KG---GNNKLIKIFHRGGKYGF-SEPLTFLSVV--------------------------ELINHYRHESLA--------QYNAKLDSHL---LFPVSKY-QQ--- T_nigroviridis_ENSTNIP00000014006 ASSKLEGEYTLTLR-KG---GNNKLIKIYHREGRYGF-SEPLTFLSVV--------------------------ELINHYRHESLA--------QYNAKLDTKL---LYPVSKY-QQ--- T_rubripes_ENSTRUP00000018794 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKH-QQ--- T_rubripes_ENSTRUP00000027602 ASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNPKLDVKL---LYPVSKH-QQ--- A_carolinensis_ENSACAP00000016070 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- T_nigroviridis_ENSTNIP00000022063 ASTKMHGDYTLTLRWKG---GNNKLIKIFHREGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNPKLDVKL---LYPVSKH-QQ--- G_aculeatus_ENSGACP00000020473 ASSRLEGEYTLTLR-KG---GNNKLIKIYYRDGRYGF-SEPLTFLSVV--------------------------ELIDHYRHESLA--------QYNGKLDTKL---LFPVSKY-QQLVA M_mulatta_ENSMMUP00000015140 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- G_gallus_ENSGALP00000023822 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- D_rerio_ENSDARP00000056212 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRTESLA--------QYNPKLDVKL---LYPVSKH-QQ--- E_caballus_ENSECAP00000017836 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- M_domestica_ENSMODP00000024566 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- P_pygmaeus_ENSPPYP00000017341 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- C_familiaris_ENSCAFP00000011322 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- G_aculeatus_ENSGACP00000001371 ASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNPKLDVKL---LYPVSKHQQQ--- O_latipes_ENSORLP00000021829 ASTKMHGDYTLTLR-KG---GNNKLIKIFHREGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNPKLDVKL---LYPVSKH-QQ--- H_sapiens_ENSP00000379855 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- P_troglodytes_ENSPTRP00000029009 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- T_guttata_ENSTGUP00000003114 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- X_tropicalis_ENSXETP00000046442 ASTIMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELITHYRNESLA--------QYNPKLDVKL---LYPVSKF-QQ--- B_taurus_ENSBTAP00000014594 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- M_musculus_ENSMUSP00000056774 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- G_aculeatus_ENSGACP00000020881 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---QFPVSKH-QQ--- G_gallus_ENSGALP00000037576 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---MYPVSRY-QQ--- T_guttata_ENSTGUP00000008408 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---MYPVSRY-QQ--- E_caballus_ENSECAP00000007453 LSS--QQQQFLLSR-PG---GQEPQVQVRRRERLGSF-QEPCQ-CAVP--------------------------SCQASHSPTCLS--------KGHARSGTAL---MALVC---PQ--- O_cuniculus_ENSOCUP00000004433 ASTKMHGDYTLTLR-KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- O_latipes_ENSORLP00000003326 SCERCR---TXAFR-KG---GNNKLIKIFHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKQ-QQ--- R_norvegicus_ENSRNOP00000025687 SWKNNGGGWRYL---KG---GNNKLIKIFHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSKY-QQ--- X_tropicalis_ENSXETP00000007065 ASTKVQGDYTLTLR-KG---GNNKLIKIYHQDGKYGF-SDPLTFNSVV--------------------------ELINHYRNESLA--------QYNPKLDVKL---LYPVSRY-QQ--- A_carolinensis_ENSACAP00000015633 ASTKKQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPISRY-QQ--- R_norvegicus_ENSRNOP00000000157 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- G_aculeatus_ENSGACP00000006864 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNTKLDVKL---VYPISRF-QQ--- C_familiaris_ENSCAFP00000006438 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- M_mulatta_ENSMMUP00000040267 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- B_taurus_ENSBTAP00000003878 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELISHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- P_pygmaeus_ENSPPYP00000001627 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- P_troglodytes_ENSPTRP00000001190 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- H_sapiens_ENSP00000361075 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- M_musculus_ENSMUSP00000030464 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFTSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---TYPVSRF-QQ--- D_rerio_ENSDARP00000040333 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELISHYRHESLA--------QYNTKLDVKL---MYPVSRY-QQ--- O_latipes_ENSORLP00000016725 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SEPLTFNSVV--------------------------DLISHYRHESLA--------QYNTKLDVKL---MYPVSRF-QQ--- T_rubripes_ENSTRUP00000000305 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFSSVV--------------------------ELIGHYRHESLA--------QYNTKLDVKL---MFPISRF-QQ--- O_anatinus_ENSOANP00000009424 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYRHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- X_tropicalis_ENSXETP00000028313 ASSKIRGEYTLTLR-KG---GNNRLIKIFHRDDMYGF-SEPLTFTSVV--------------------------ALINHYRHESLA--------QYNAKLDTRL---LYPMSKY-QQLLY O_cuniculus_ENSOCUP00000012307 XXXXXXXXXXXXXX-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- T_rubripes_ENSTRUP00000030226 ASTKLQGDFTLTLR-KD---GHNKLIKIYHRDGKYGF-SDPLTFTSVV--------------------------ELIWYYQHHSLV--------EYNAMLDLML---IYPVSRF-QK--- O_latipes_ENSORLP00000013359 ASTKLQGDFTLTLR-KD---GHNKLIKIYHCDGKYGF-SDPLTFTSVV--------------------------ELIWYYQHHSLV--------EYNATLDLML---TNPVSRF-QQ--- G_aculeatus_ENSGACP00000021319 ASTKLQGDFTLTLR-KD---GHNKLIKIYHCDGKYGF-SDPLTFTSVV--------------------------ELIWHYQHHPLV--------EYNATLDLML---THPVSRF-QQ--- T_nigroviridis_ENSTNIP00000009742 ASTKLQGDFTLTLR-SDEGHGHNKLIKIYHREGKYGF-SDPLTFTSVV--------------------------ELIWYYQHHSLV--------EYNAMLDLML---TYPVSRF-QT--- G_aculeatus_ENSGACP00000010853 ASSKVKGEYTLTLR-KD---GYNRLIKIFHRGGKYGF-SEPVGFASVV--------------------------NLIQFYQNKSLA--------QYNSKLDTKL---LYPITRY-QQ--- T_rubripes_ENSTRUP00000017331 ASSKVKGEYTLTLR-KD---GSNRLIKIFNKQGRVGF-TEPLAFPSVV--------------------------HLIQYYQNRSLA--------QYNAKLDTRL---LYPVSRH-QQ--- T_nigroviridis_ENSTNIP00000013096 ASSKVEGEYTLTLR-KD---GSNRLIKIFNKGGRAGF-TEPLAFTSVV--------------------------HLIRFYQNRSLA--------QYNAKLDTRL---LYPVSRH-Q---- G_gorilla_ENSGGOP00000009961 ASTKMQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFNSVV--------------------------ELINHYHHESLA--------QYNPKLDVKL---MYPVSRY-QQ--- M_domestica_ENSMODP00000002600 ASTKVQGDYTLTLR-KG---GNNKLIKIYHRDGKYGF-SDPLTFSSVV--------------------------ELINHYRHESLA--------QYNPKLDTGLGGSSASPSCA-RQ--- A_carolinensis_ENSACAP00000012532 ASSKIQGEYTLTLR-KG---GNNKLIKIFHREGKYGF-SEPLTFGSVV--------------------------ELINHYRHESLA--------QYNAKLDTRL---LYPISKF-QQ--- T_nigroviridis_ENSTNIP00000006602 GSFLVQGDYTLTPG-KG---GSNKLIRILHGDGRFGF-SEPLTFDSVV--------------------------ELIGHHQHQSLA--------QYNSKLDVRL---LFPVSRF-QQ--- D_rerio_ENSDARP00000089169 ASCKVQGEYTLTVR-NN---GTNKLIRILHQEGKFGF-SEPLTFSSVP--------------------------ELISFYRHRSLV--------HYNTSLDVTL---AYPVTHC-NT--- A_aegypti_AAEL013596-PA ASSG-NGEYTLTLK-KD---GADRVIKIFHTQDKYGF-TRDGSHNSVV--------------------------DLINFYRNVSLK--------EYNTILDIKL---MYPISRF-ED--- C_intestinalis_ENSCINP00000004274 -SANSDREYTLTLR-KG---GSNKLIRIMSRNGMYGF-AEPLIFNSVI--------------------------QLVNHYRNEPLT--------RYNPDLDITL---RYPAPKQ-QA--- A_gambiae_AGAP005583-PA AIND-AGEFTLVLK-KD---GTDRPIKIYHKNGKYGF-TQECTFESLV--------------------------GMINEFRTTTLK--------EYNTILDISL---LYPISRF-ED--- D_melanogaster_FBpp0077791 ALSM-KGEYTLTLM-KD---GCEKLIKICHMDRKYGF-IETDLFNSVV--------------------------EMINYYKENSLS--------MYNKTLDITL---SNPIVRA-RE--- T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 XXXXXXXXXXXXXX-XX---XXXXXXXXXXXXXXXXX-XXXXXXXXXX--------------------------XXXXXXXXXXXX--------XXXXXXXXXX---XXXXXXX-XX--- C_elegans_Y110A7A.10 AST--PGDYTLSVK-FA---AQVKLLRIVVKDGKCGFNTDSLTHDSVV--------------------------RLIEFHRNISLN--------IFNDALDVRL---LYPVSVR-RNSQN T_guttata_ENSTGUP00000000990 M---LHNQYVLALK------GAQ-----LHQHQYYDS-TLPLLLDSLQKMQEEMIKALKGILDEYSEITSLVTEEIVNVHKEIQTSVEQIDPNSEYNDFIDTHR------SSEVVEQEIE R_norvegicus_ENSRNOP00000021758 M---LHNQYVLALK------GAQ-----LHQSQYYDT-TLPLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKEIQMSVDQIDPSTEYNDFIDVHR------TTAAKEQEIE 730 740 750 760 770 780 790 800 810 820 830 840 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- P_troglodytes_ENSPTRP00000018245 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- M_mulatta_ENSMMUP00000004228 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- B_taurus_ENSBTAP00000003033 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- C_familiaris_ENSCAFP00000022072 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- M_musculus_ENSMUSP00000034296 -DQV-VKED--SIEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- R_norvegicus_ENSRNOP00000026210 -DQV-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- P_pygmaeus_ENSPPYP00000010903 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- O_anatinus_ENSOANP00000002082 -DQV-VKED--SVEA----------------VGEQLKVYHQQYQDKSREYDLLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---QFRR----- G_gallus_ENSGALP00000005414 -DQV-VKED--SVEA----------------VGEQLKVYHQQYQDKSWEYDLLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--CQTQEKCSKEYIE---RFRR----- G_gorilla_ENSGGOP00000015802 -DQI-VKED--SVEA----------------VGAQLKVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- M_domestica_ENSMODP00000002126 -DQV-VKED--SVEA----------------VG-QLKVYHQQYQDQSREYDLLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKDYLE---RFRR----- T_guttata_ENSTGUP00000000409 -DQV-VKED--SVEA----------------VGEQLKVYHQQYQDKSWEYDLLY--EEYTRT-------SQVWTPRRTGFEEGDILPAARRELLWGNPREKCSKGVHE---RFRR----- T_rubripes_ENSTRUP00000026404 TAQL-VKEN--SIEE----------------VGEQLKVYHEQYQEKSREYDCLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--CETQERYSRESLE---RFQR----- D_rerio_ENSDARP00000090206 -DQV-VKED--SIEA----------------VGEQLKVYHEQYQEKSREYDVLY--EEYTRS-------SQELQMKRTAIEAFNETIKIFEEQ--CETQERLSRDSIE---KFRR----- T_nigroviridis_ENSTNIP00000014006 -SQL-VKEN--SIEE----------------VGEQLKVYHDQYQEKSREYDCLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--CETQERYSRESLE---RFQR----- T_rubripes_ENSTRUP00000018794 -DQV-VKED--NIEA----------------VGRKLCEYHQQYQEKNKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFRR----- T_rubripes_ENSTRUP00000027602 -DQV-VKED--SIEA----------------VGKKLHEYHLQYQEKNREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERFSKEYID---KFRR----- A_carolinensis_ENSACAP00000016070 -DQV-VKED--SIEA----------------VGKKLHEYNIQFQEKNREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- T_nigroviridis_ENSTNIP00000022063 -DQV-V-ED--SIEA----------------VGKKLHEYHLQYQEKNREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERFSKEYID---KFRR----- G_aculeatus_ENSGACP00000020473 CTQL-VKEN--SIEE----------------VGEQLKVYHEQYQEKSREYDSLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--CETQERYSRESLE---KFQR----- M_mulatta_ENSMMUP00000015140 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- G_gallus_ENSGALP00000023822 -DQV-VKED--SIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- D_rerio_ENSDARP00000056212 -DQV-VKED--NIEA----------------VGKKLHEYHQQFQEKNREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFRR----- E_caballus_ENSECAP00000017836 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- M_domestica_ENSMODP00000024566 -DQV-VKED--SIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- P_pygmaeus_ENSPPYP00000017341 -DQ--VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- C_familiaris_ENSCAFP00000011322 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQSQERYSKEYIE---KFKR----- G_aculeatus_ENSGACP00000001371 -DQV-VKED--SIEA----------------VGKKLHEYHLQFQEKNREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERFSKEYIE---KFRR----- O_latipes_ENSORLP00000021829 -DQV-VKED--SIED----------------VGKKLHEYHLQYQEKNREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERFSKEYIE---KFRR----- H_sapiens_ENSP00000379855 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- P_troglodytes_ENSPTRP00000029009 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- T_guttata_ENSTGUP00000003114 -DQV-VKED--SIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- X_tropicalis_ENSXETP00000046442 -DQL-VKED--SIEA----------------VGKKLREYNVQFEEKNQEYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQEKYSKEYIE---KFRR----- B_taurus_ENSBTAP00000014594 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EDYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- M_musculus_ENSMUSP00000056774 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- G_aculeatus_ENSGACP00000020881 -DQV-VKED--NIEA----------------VGRKLCEYHQQFQEKNKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFRR----- G_gallus_ENSGALP00000037576 -DQL-VKED--NIDA----------------VGKKLQEYHAQYQEKSKEYDKLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHSQERYSKEYIE---RFRR----- T_guttata_ENSTGUP00000008408 -DQL-VKED--NIDA----------------VGKKLQEYHAQYQEKSKEYDKLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHSQERYSKEYIE---RFRR----- E_caballus_ENSECAP00000007453 -DQI-VKED--SVEA----------------VGAQLRVYHQQYQDKSREYDQLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--GQTQEKCSKEYLE---RFRR----- O_cuniculus_ENSOCUP00000004433 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- O_latipes_ENSORLP00000003326 -DQV-VKED--NIEA----------------VGRKLCEYHQQYQEKNKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKDYIE---RFRK----- R_norvegicus_ENSRNOP00000025687 -DQV-VKED--NIEA----------------VGKKLHEYNTQFQEKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERYSKEYIE---KFKR----- X_tropicalis_ENSXETP00000007065 -DQL-VKED--NIDA----------------VGRKLQEYHGQFQDKSKEYDKLY--EEYTKT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKEYME---RFNR----- A_carolinensis_ENSACAP00000015633 -DQL-VKED--NIDA----------------VGKKLQEYHTQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQYSKEYIE---RFRR----- R_norvegicus_ENSRNOP00000000157 -DQL-VKED--NIDA----------------VGKNLQEFHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKDYIE---RFRR----- G_aculeatus_ENSGACP00000006864 -DQL-VKED--NIDA----------------VGKKLQEYHNQYQEKNKEYDRLY--EEYTKT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKDYIE---RFRR----- C_familiaris_ENSCAFP00000006438 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- M_mulatta_ENSMMUP00000040267 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- B_taurus_ENSBTAP00000003878 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRK----- P_pygmaeus_ENSPPYP00000001627 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- P_troglodytes_ENSPTRP00000001190 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- H_sapiens_ENSP00000361075 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- M_musculus_ENSMUSP00000030464 -DQL-VKED--NIDA----------------VGKNLQEFHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKDYIE---RFRR----- D_rerio_ENSDARP00000040333 -DQL-VKED--NIDA----------------VGRKLQEYHNQYQEKSKEYDRLY--EEHTKT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKEYIE---RFRR----- O_latipes_ENSORLP00000016725 -DQL-VKED--NIDA----------------VGKKLQEYHNQYQDKSKDYDRLY--EDYTKT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKDYIE---RFHR----- T_rubripes_ENSTRUP00000000305 -DQL-VKED--NIDA----------------VGKKLQEYHCQYQDRNKEYDRLY--EEYTKT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKDHIE---RFCR----- O_anatinus_ENSOANP00000009424 -DQL-VKED--SIDA----------------VGKKLQEYHAQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQERYSKEYIE---RFRR----- X_tropicalis_ENSXETP00000028313 INYLPVSPD--SLQI----------------SSVILAVY---------SYPKFFRPEKRSEN-------SSGTPCRSNLCSGLHQEIEKYEHF--SHSSKKIFCTNFSLPIRFLR----- O_cuniculus_ENSOCUP00000012307 -DQL-VKED--NIDA----------------VGKKLQEYHSQYQEKSKEYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- T_rubripes_ENSTRUP00000030226 -KCQ-VKGD--SVDV----------------AGRKLKEVHSQYQEKTKEFDRLY--EAFTKT-------SQEIQMKRTAIEAFNETMLIFEEQ--CREQERYGEEIDR---NNCS----- O_latipes_ENSORLP00000013359 -VSV-VKED--NVDV----------------AGRKLKELHNQYQVKSKEFDQLY--EAFTKT-------SQEIQMKRTAIEAFNETMMIFEEQ--CREQERYGEEIER---N--S----- G_aculeatus_ENSGACP00000021319 -ESDTVKED--SVDV----------------AGRKLKEVHCHYQERSKEFDRLY--EAFTKT-------SQEIQMKRTAIEAFNETMLIFEEQ--CREQERYGEKFEM---NNHS----- T_nigroviridis_ENSTNIP00000009742 -KFQ-VKGD--SVDV----------------AGRKLKEVHSQYQEKTKEFDRLY--EAFTKT-------SQEIQMKRTAIEAFNETMLIFEEQ--CREQERYGEEIDR---NNCS----- G_aculeatus_ENSGACP00000010853 -QQI-AV----DIDA----------------VGEQLRIFQDQYKEKSKEYDRLF--EKFNQT-------SQELQSKRTAIEAFSEIIRIFEEE--CETQERYSKEYID---MFMT----- T_rubripes_ENSTRUP00000017331 --QV-VMEI--NIEA----------------VGQQLRMLQDQYKEKSKEYDRLY--EKFNQT-------SQDLQSNRTAIEAFGEIIRIFEEE--CETQERYSKEYID---MFLT----- T_nigroviridis_ENSTNIP00000013096 --QV-VMEI--DIDA----------------VGQQLRMLQDQYKEKSKEYDLLY--EKFNQT-------SQDLQSKRTAIEAFGEIIRIFEEE--CETQERYSKEYID---MFLA----- G_gorilla_ENSGGOP00000009961 -DQL-VKED--NIDA----------------VGKKLQXXXXXXXXXXXXXXXXX--XXXXXX-------XXEIQMKRTAIEAFNETIKIFEEQ--CHTQEQHSKEYIE---RFRR----- M_domestica_ENSMODP00000002600 -DQL-VKED--NIDA----------------VGTKLQEYHSQYQDKSREYDRLY--EEYTRT-------SQEIQMKRTAIEAFNETIKIFEEQ--CQTQERQSKDYIE---RFRR----- A_carolinensis_ENSACAP00000012532 -DQV-VKED--SVEA----------------VGEQLKAYHQQYQDKSREYDLLY--EEYTRT-------SQELQMKRTAIEAFNETIKIFEEQ--CQTQEKCSQDYME---RFRR----- T_nigroviridis_ENSTNIP00000006602 -DQL-LKEV--TLEE----------------VGRRLQEYHSQFQEQSRQYDRLQ--EDYART-------SQEIQMKRTAIEAFNETISIFEEQ--CHTQERQRQD---------Q----- D_rerio_ENSDARP00000089169 -DLP-VKEE--FLSA----------------TREKLQECFRVFQ-KTAEYDQLY--DTCTSL-------LKEIQ-RRKAFEDISMT-EISKPQ--CYSQENFQNTLQK---EYFT----- A_aegypti_AAEL013596-PA -DTY-ISSTGDDTPR----------------LAQKFIEISQMLNDKLHERERLQ--EDLNMS-------KNQVDLKKQAQEAFIEAEKLFQDQ--LAIQAKFVS---------------- C_intestinalis_ENSCINP00000004274 -TTE-LSDE--SKEA----------------LFRALLEDDKTFIKISDDYQDIF--ATFNAR-------QQDIQNMKTAISAYEETISMFKEQ--CSTLTTYMDQ---------A----- A_gambiae_AGAP005583-PA -ESL-YPAAG-DIHQ----------------LAASFYETVQKLTDLQNMRESTL--EAFNVC-------QSHMELRRQAQEAFIEADKLFNDQ--LLTQARYEK---------------- D_melanogaster_FBpp0077791 -DEE-SQPHG-DLCL----------------LSNEFIRTCQLLQNLEQNLENKR--NSFNAI-------REELQEKKLHQSVFGNTEKIFRNQ--IKLNESFMKAPAD---APSTEAGGA T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 -XXX-XXXX--XXXX----------------XXXXXXXXXXXXXXXXXXXXXXX--XXXXXX-------XXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXX---XXXX----- C_elegans_Y110A7A.10 GKPF-FKKG--QLQQRMILSAKNDHDWRERLEMENLRAVHLAFERGAKLYDSAH--QEMERAESLYHALNQSVRDNEIKLGKLNNLLEAETD---VVTQIQGSQTTSEML---------- T_guttata_ENSTGUP00000000990 FDTS-LLEENENLQA------------------NEIMWNNLTAESLQVMLKTVI--EELMQT-------QQTLLSKEELVLDLEKKIEESSKT--C---EKKSDIVLL------------ R_norvegicus_ENSRNOP00000021758 FDTS-LLEENENLQA------------------NEIMWNNLTADSLQVMLKTLA--EELTQT-------QQMLLHKEAAVLELEKRIEESSET--C---AKKSDIVLL------------ 850 860 870 880 890 900 910 920 930 940 950 960 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQQLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- P_troglodytes_ENSPTRP00000018245 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQQLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- M_mulatta_ENSMMUP00000004228 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQQLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- B_taurus_ENSBTAP00000003033 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQELRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- C_familiaris_ENSCAFP00000022072 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQELRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- M_musculus_ENSMUSP00000034296 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQDLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQRKINEWLGIKNE-TE--D- R_norvegicus_ENSRNOP00000026210 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQDLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQRKINEWLGIKNE-TE--D- P_pygmaeus_ENSPPYP00000010903 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQQLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- O_anatinus_ENSOANP00000002082 ----------EGNEKEIQ-RILINSEKLKSRIAEIHNSKIKLEHDLRVQ-------SADNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGTRQKKINEWLGIKNE-NE--D- G_gallus_ENSGALP00000005414 ----------EGNEKEVQ-RILMNSEKLKSRITEIHDSKMKLEQDLKKQ-------ASENREIDKRMNSLKP-----DLMQLRKLRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- G_gorilla_ENSGGOP00000015802 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQQLRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVXXXX-XGARQKKINEWLGIKNE-TE--D- M_domestica_ENSMODP00000002126 ----------EGNEKEIQ-RILMNSEKLKSRIAEIHDSKMKLEQDLRAQ-------AADNREIDKRMNSLKP-----DLMQLRKIRDQYLVMDERLRGGTERRPGRALRLPPSLTH--S- T_guttata_ENSTGUP00000000409 ----------EGKE-EVQ-RILMNSEKLKSRITEIHDSKMKLEQDLKKQ-------ASENREIDKRMNSLKP-----DLMQLRKLRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- T_rubripes_ENSTRUP00000026404 ----------EGNEKEIQ-KIQSNSERLKSRVKEIHDSKRKLEQDLRQQ-------VSDNREIDKKMNSLKP-----DLMQLRKIREQYLIWLTQ-KGTRQKKINEWLGIKNE-AD--D- D_rerio_ENSDARP00000090206 ----------EGNDKEIE-RIQSNSEKLKSRVTEIHDSKRKLELDLKRQ-------ATDNREIDKLMNSLKP-----DLIQLRKLRDQYLVWLTQ-KGTRQRKINEWLGIKNE-SE--D- T_nigroviridis_ENSTNIP00000014006 ----------EGNEKEIQ-KIQSNSERLKSRVKEIHDSKRKLEQDLRQQ-------ASDNREIDKKMNSLKP-----DLM-LRKIREQYLIWLIQ-KGTRQKKINEWLGIKNE-AD--D- T_rubripes_ENSTRUP00000018794 ----------EGNEKEIQ-RIMGNYEKLKSRISEIVDSKRRLEEDLKKQ-------AADYREIDKRMNSIKP-----DLIQLRKTRDQYLLWLTQ-KGVRQKKLNEWLGIKNENTE--D- T_rubripes_ENSTRUP00000027602 ----------EGNDKEIQ-RIMENYDKLKSRISEIVDSKRHLEVDLKKQ-------AADYREIDKKMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQRKLNEWLGLKNETTE--D- A_carolinensis_ENSACAP00000016070 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRHRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- T_nigroviridis_ENSTNIP00000022063 ----------EGNDKEIQ-RIMENYDKLKSRISEIVDSKRHLEVDLKKQ-------AADYREIDKKMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQRKLNEWLGLKNETTE--D- G_aculeatus_ENSGACP00000020473 ----------EGNEKEIQ-KIQSNSERLKSRVKEIHDSKRKLEQDLRQQ-------VSDNREIDKKMNSLKP-----DLMQLRKIRDQYFIWLTQ-KGTGQKKINEWLGIKND-AD--D- M_mulatta_ENSMMUP00000015140 ----------EGNEKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- G_gallus_ENSGALP00000023822 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- D_rerio_ENSDARP00000056212 ----------EGNEKEIQ-RIMVNYEKLKSRISEIVDSKRRLEEDLKKQ-------AADYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLGIKNENQD--D- E_caballus_ENSECAP00000017836 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- M_domestica_ENSMODP00000024566 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- P_pygmaeus_ENSPPYP00000017341 ----------EGNEKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- C_familiaris_ENSCAFP00000011322 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- G_aculeatus_ENSGACP00000001371 ----------EGNDKEIQ-RIIENYDKLKSRISEIVDSKRHLEVDLKKQ-------AADYREIDKKMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQRKLNEWLGLKNETVE--E- O_latipes_ENSORLP00000021829 ----------EGNEKEIQ-RIMENYDKLKSRISDIVDSKRHLEADLKKQ-------AADYREIDKKMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQRKLNEWLGLKNETTE--D- H_sapiens_ENSP00000379855 ----------EGNEKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--EN P_troglodytes_ENSPTRP00000029009 ----------EGNEKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--EN T_guttata_ENSTGUP00000003114 ----------EGNEKEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENAE--D- X_tropicalis_ENSXETP00000046442 ----------EGNEKEIQ-RILHNHEKLKSRISEIVDSKRRLEEDLKKQ-------TAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--SENTE--D- B_taurus_ENSBTAP00000014594 ----------EGNETEIQ-RIMHNYEKLKSRISEIVDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- M_musculus_ENSMUSP00000056774 ----------EGNEKEIQ-RIMHNHDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- G_aculeatus_ENSGACP00000020881 ----------EGNDKEIQ-RIMGNYEKLKSRISEIVDSKRRLEEDLKKQ-------AADYREIDKRMNSIKP-----DLIQLRKTRDQYLTWLTQ-KGVRQKKLNEWLGIKNENTE--D- G_gallus_ENSGALP00000037576 ----------EGNEKEIE-RIMMNYEKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNRETDKKMNSIKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGIKNENID--D- T_guttata_ENSTGUP00000008408 ----------EGNDKEIE-RDMMNYEKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNRETDKKMNSIKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGIKNENID--D- E_caballus_ENSECAP00000007453 ----------EGNEKEMQ-RILLNSERLKSRIAEIHESRTKLEQELRAQ-------ASDNREIDKRMNSLKP-----DLMQLRKIRDQYLVWLTQ-KGARQKKINEWLGIKNE-TE--D- O_cuniculus_ENSOCUP00000004433 ----------EGNEKEIQ-RIMHNYDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- O_latipes_ENSORLP00000003326 ----------EGNEKEIQSRIMGNYEKLKSRISEIVDSKRRLEEDLRKQ-------AADYREIDKRMNSIKP-----DLIQLRKTRDQYLTWLTQ-KGVRQKKLNEWLGIKNENTE--D- R_norvegicus_ENSRNOP00000025687 ----------EGNEKEIQ-RIMHNHDKLKSRISEIIDSRRRLEEDLKKQ-------AAEYREIDKRMNSIKP-----DLIQLRKTRDQYLMWLTQ-KGVRQKKLNEWLG--NENTE--D- X_tropicalis_ENSXETP00000007065 ----------EGNEKEME-RIIMNYEKLKSRLGEIHDSKLRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGIKNENID--D- A_carolinensis_ENSACAP00000015633 ----------EGNEKEIE-RIMMNYEKLKSRLGEIHDSKLRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGIKNENID--D- R_norvegicus_ENSRNOP00000000157 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKVRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-RGVRQRRLNAWLGIKSEDTD--G- G_aculeatus_ENSGACP00000006864 ----------EGNDKEIE-RIMMNYEKLKSRLGEIHDSKVRLEQDLKTQ-------AMDNRETDKKMNSLKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGIKNENTD--E- C_familiaris_ENSCAFP00000006438 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNAWLGIKNEDAD--E- M_mulatta_ENSMMUP00000040267 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNAWLGIKNEDAD--E- B_taurus_ENSBTAP00000003878 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNAWLGIKNEDAD--E- P_pygmaeus_ENSPPYP00000001627 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNVWLGIKNEDAD--E- P_troglodytes_ENSPTRP00000001190 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNVWLGIKNEDAD--E- H_sapiens_ENSP00000361075 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKNQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNVWLGIKNEDAD--E- M_musculus_ENSMUSP00000030464 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKLRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-RGVRQRRLNAWLGIKNEDSD--E- D_rerio_ENSDARP00000040333 ----------EGNDKEIE-RIMMNYEKLKSRLGEIHDSKTRLEQDLKTQ-------ALDNRETDKKMNSLKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGLKNETTD--D- O_latipes_ENSORLP00000016725 ----------EGNDKEIE-RIMMNYEKLKSRLGEIHDSKVRLEQDLKTQ-------AMDNRETDKKMNSLKP-----DLIQLRKIRDQYLVWLNH-KGVRQKRINDWLGLKNENTD--E- T_rubripes_ENSTRUP00000000305 ----------ECNDKEME-RILVNYEKLKSRLSEIHDSKVRLEQDLKTQ-------AMDIRETDKKMNSLKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRINDWLGIKNENPD--E- O_anatinus_ENSOANP00000009424 ----------EGNEKEIE-RIMMNYEKLKSRLGEIHESKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQYLVWEKK-MGRPQRRERRGLASSWDGND--P- X_tropicalis_ENSXETP00000028313 ----------KXNNKEIE-RIMMNSEKLKSRVTEIHDSKMKLEQDLKKQ-------ASENREIDKKMNSLKP-----DLMQLRKLRDQYLLWLLE-KGARQKDVSEWLDMKNE-PE--D- O_cuniculus_ENSOCUP00000012307 ----------EGNEKEIE-RIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ-------ALDNREIDKKMNSIKP-----DLIQLRKIRDQHLVWLNH-KGVRQKRLNAWLGIKNEDAD--E- T_rubripes_ENSTRUP00000030226 ----------EADDKDLE-SFLINYEKLKCRLGEIYDSKIHLEEDLRTQ-------VEDYRETDRKMNSLRP-----DLIQLRNIRDQYLNWLNH-KGVRQKRINDWLGTQGDSLD--D- O_latipes_ENSORLP00000013359 ----------EGTDNDLE-SFLINYEKLKCRLGEIYDSKIHLEEDLRIQ-------VEDYRDTDRKINSLRP-----DLIQLRNIRDQYLNWLNH-KGVRQKRINDWLGIHNDSFD--D- G_aculeatus_ENSGACP00000021319 ----------EGADKDLE-SFLINYEKLKCRLGEIYESKIHLEDDLRTQ-------VEDYRETDRKINSLRP-----DIIQLRNIRDLYLNWLNH-KGVRQKRINDWLGILSDSLD--D- T_nigroviridis_ENSTNIP00000009742 ----------EGADTDLE-SFLINYEKLKCRLGEIYDSKIHLEEDLRTQ-------VEDYRETDRKMNSLRP-----DLIQLRNIRDQYLNWLNH-KGVRQKRINDWLGAQNDSLD--D- G_aculeatus_ENSGACP00000010853 ----------LDSITQTD-KIQNNSDELQSRVEEIHNSKKKLEEELRRK-------AVAHMEVDKKMDSLKP-----DLVQLRKIRDQYLLWLTQ-QGTRQSQINDWLGIKNE-EE--D- T_rubripes_ENSTRUP00000017331 ----------LDNGAETD-KIQSGSDELQSRVEEIHSSKKKLEEELRSK-------ALAHMEMDKKINSLRP-----DLMQLRKLRDQYLLWLTQ-QGFRQSQINDWLGIRNE-EESSS- T_nigroviridis_ENSTNIP00000013096 ----------LDTGAESD-KIQSSSDELQSRVEEIHSSKKQLEEELRSK-------ALAHMEMDKKIHSLRP-----DLMQLRKLRDQYLLWLAQ-QGIRQSQINHWLGISSQ-EE--D- G_gorilla_ENSGGOP00000009961 ----------EGNEKEIE-RXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXWLNH-KGVRQKRLNVWLGIKNEDAD--E- M_domestica_ENSMODP00000002600 ----------EGNEKEIE-RLQG---------WRLHEAPPGTIETLPAL-------GIDQWEGEGGASAQQPTGHLGSLLQGPKVGR---CGVGL-ALLGPSRVQHTPGLLAPDTA--P- A_carolinensis_ENSACAP00000012532 ----------EGNDKELQ-R---------------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006602 ----------AGPEAGPE-RVLLTYERLKERLSEIHLSRQRLEEELRSQ-------DQELRQAQQQMSGLRP-----HLLRLRRLRDQHLLWLNR-RGVRQRRISDWLGMRSPEEE--R- D_rerio_ENSDARP00000089169 ----------EVNIEICS-RRSLNLANFEERIKCL-DVHLNYDIDYCLW-------ILHFKKTSRNVNSLQC-----SLKYLQKLKKAINLKLNK-FSVAQKLINKKMEFRSKYPE--I- A_aegypti_AAEL013596-PA ----------EAQPHEKQ-GISTNNKLIRDRMQELNQCRDQLQEDMKIE-------KTRIWQLERDINKLNP-----NIMSLSKEKTSYIEELKR-QGISESQIKQME------TD--G- C_intestinalis_ENSCINP00000004274 ----------QGSHEE-H-RLKENFRRMQTRLLFIVNQCEDLRTQLGQE-------IQENRERDRRLNSIKA-----DMYQLKKLRDSRISHLKA-MRISEEVINNQLRIDEEDEN--E- A_gambiae_AGAP005583-PA ----------EAQPHEQR-SLAQNRTLIESRLEELRKCKKNLDEDMERE-------RERMRELQREAMKLKP-----EIMNLSKQKDQYLEALKR-QSITDAQIKQILK---D-----G- D_melanogaster_FBpp0077791 GDGANAAASAAANANARR-SLQEHKQTLLNLLDALQAKGQVLNHYMENK-------KKEELLLERQINALKP-----ELQILQLRKDKYIERLKG-FNLKDDDLKMILQMGFD-----K- T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 ----------XXXXXXXX-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXX-XXXXXXXXXXXXX--XXXXX--X- C_elegans_Y110A7A.10 ----------KGAFANNKTFVEESIRRINTELTSSKDKKKTLSGILD--------------EIAMKRSNSKT-----RLCKLMELRSAVYDKMEP---ALCSRMAAMLDAGAEMINSEP- T_guttata_ENSTGUP00000000990 ----------LSQKQALE-ELKQTVQQLKCSEAKFAAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMDK---KDKVSRFDTIRHSIAGIIRS--------PKSMLGSSSKFFD---- R_norvegicus_ENSRNOP00000021758 ----------LGQKQALE-ELKQSVQQLRCTEAKCAAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMER---KERLSKFESIRHSIAGIIKS--------PKSVLGSSTQLSD---- 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK P_troglodytes_ENSPTRP00000018245 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK M_mulatta_ENSMMUP00000004228 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK B_taurus_ENSBTAP00000003033 -------Q-YSLME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK C_familiaris_ENSCAFP00000022072 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK M_musculus_ENSMUSP00000034296 -------Q-YSLME--DEDAL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK R_norvegicus_ENSRNOP00000026210 -------Q-YSLME--DEDAL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK P_pygmaeus_ENSPPYP00000010903 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSV------------------FGFAEPYNLYGSLK O_anatinus_ENSOANP00000002082 -------Q-YSMME--DEEDL-----PHHEEQTWYVGKINRGQAEEMLCGK----------------RDGTFLIRES-SQRGCYACSVVVDGDIKHCV-IYKTVTGYGFAEPYNLYASLK G_gallus_ENSGALP00000005414 -------Q-YSMMD--DEEEL-----PHHEERTWYVGKINRLQAEEMLCGK----------------RDGTFLIRES-SQKGCYACSVVVDGDTKHCV-IYKTATGYGFAEPYNLYASLK G_gorilla_ENSGGOP00000015802 -------Q-YALME--DEDDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLK M_domestica_ENSMODP00000002126 -------Q-YSMVD--EEEDL-----PHHEERTWYVGKINRGRAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYKTVTGYGFAEPYNLYASLK T_guttata_ENSTGUP00000000409 -------Q-YSMMD--DEEEL-----PHHEERTWYVGKINRVQAEEMLCGK----------------RDGTFLIRES-SQKGCYACSVVVDGDTKHCV-IYKTATGYGFAEPYNLYASLK T_rubripes_ENSTRUP00000026404 -------S-YSLEE---DEGS-----PHHDESTWYVGDIKRSHAEELLRGK----------------CDGTFLIRESQTQKGSYACSVVVDGDAKHCV-VYKTVTGYGFAEPYNLYSSLK D_rerio_ENSDARP00000090206 -------F-YSLLD--DDDDQ-----AHHDECSWYVGDIKRSYAEDLLRGK----------------RDGTFLIRESQTQKGSFACSVVVEGEIKHCV-VYKTATGFGFAEPYNLYGSLK T_nigroviridis_ENSTNIP00000014006 -------S-YSLEE---DESS-----PHHDESTWYVGDIKRSQAEEMLRGT----------------CDGTFLIRESQTQKGSYACSVVVDGDTKHCV-VYKTVTGYGFAEPYNLYSSLK T_rubripes_ENSTRUP00000018794 -------Q-YSMVE--DDEDL-----PHQDERSWKLGKINRLQAEALLQGK----------------RGGTFLVRDS-SKAGCYACSVVVDGEVKHCV-INKTPSGYGFAEPYNLYSSLK T_rubripes_ENSTRUP00000027602 -------E-YSMVE--DEEDL-----PHHDERLWRLGNINRTQAESLLRGK----------------RDGTFLVRDS-SKAGCYACSVVVDGEVKHCV-INKTSTGFGFAEPYNLYASLK A_carolinensis_ENSACAP00000016070 -------Q-YSMVE--DDEDL-----PHHDERTWNVGNINRSQAENLLRGK----------------RDGTFLVRES-SKPGCYACSVVVDGEVKHCV-INKTPTGYGFAEPYNLYNSLK T_nigroviridis_ENSTNIP00000022063 -------E-YSMVE--DEEDL-----PHHDERLWRLGNINRTQAESLLRGK----------------RDGTFLVRDS-SKAGCYACSVVVDGEVKHCV-INKTSTGFGFAEPYNLYASLK G_aculeatus_ENSGACP00000020473 -------S-FSLEE---DEGS-----PHHDESTWYVGDIKRTQAEEMLRGK----------------CDGTFLIRESQSQKGSYACSVVVEGDAKHCV-IYKTATGYGFAEPYNLYSSLK M_mulatta_ENSMMUP00000015140 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK G_gallus_ENSGALP00000023822 -------Q-YSMVD--DDEDL-----PHHDERTWNVGNINRSQAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTPTGYGFAEPYNLYNSLK D_rerio_ENSDARP00000056212 -------Q-YSMVE--DDEDL-----PHHDERSWKLGNINRIQAEALLRGK----------------RDGTFLVRDS-SKAGCYACSVVVDGEVKHCV-INKTPTGYGFAEPYNLYNSLK E_caballus_ENSECAP00000017836 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK M_domestica_ENSMODP00000024566 -------Q-YSMVE--DDEDL-----PHHDERTWNVGSSNRSKAENLLRGK----------------RDGTFLVRES-SKQGCFACSVVVDGEVKHCV-INKTPTGYGFAEPYNLYNSLK P_pygmaeus_ENSPPYP00000017341 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK C_familiaris_ENSCAFP00000011322 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK G_aculeatus_ENSGACP00000001371 -------QRVQHGE--DEEDL-----PHHDERLWRLGS-TRLQAESLLRGK----------------RDGSFLVRDS-SKPGCYACSVVVDGEVKHCV-INKTSTGFGFAEPYNLYGSLK O_latipes_ENSORLP00000021829 -------E-YSMVE--DEEDL-----PHHDERLWRLGNINRGQAEALLRGK----------------RDGTFLVRDS-SKPGCYACSVVVEGEVKHCV-INKTSTGFGFAEPYNLYGSLK H_sapiens_ENSP00000379855 FLSCLPSQ-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK P_troglodytes_ENSPTRP00000029009 FLSCLPSQ-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK T_guttata_ENSTGUP00000003114 -------Q-YSMVE--DDEDL-----PHHDERTWNVGNINRSQAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTPTGYGFAEPYNLYNSLK X_tropicalis_ENSXETP00000046442 -------Q-YSVVE---DEDL-----PHQDERTWNVGNINRNQAENLLRGK----------------RDGTFLVRES-SKAGCYACSVVADGEVKHCV-INKTLTGYGFAEPYNLYSSLK B_taurus_ENSBTAP00000014594 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK M_musculus_ENSMUSP00000056774 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK G_aculeatus_ENSGACP00000020881 -------Q-YSMVD--DDEDL-----PHHDERSWKLGNINRPQAEALLQGK----------------RDGTFLVRDS-SKAGCYACSVVVEGEVKHCV-INKTSSGLGFAEPYNLYGSLK G_gallus_ENSGALP00000037576 -------T-YFVNE--EEENL-----PHHDEKTWFVGDLNRIQAEDLLCGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTPRGYGFAEPYNLYSTLK T_guttata_ENSTGUP00000008408 -------T-YFVNE--EDENL-----PHHDEKTWFVGDLNRVQAEDLLCGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTPRGYGFAEPYNLYSTLK E_caballus_ENSECAP00000007453 -------Q-YALME--DEEDL-----PHHEERTWYVGKINRTQAEEMLSGK----------------RDGTFLIRES-SQRGCYACSVVVDGDTKHCV-IYRTATGFGFAEPYNLYGSLR O_cuniculus_ENSOCUP00000004433 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAETLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK O_latipes_ENSORLP00000003326 -------Q-YSMVE--DDEDL-----PHHDERTWKLEKIDRLEAEGLLQGK----------------RDGTFLVRES-SKPGCYACSVMVDGEVKHCV-INKTPSGYGFAEPYNLYSSLK R_norvegicus_ENSRNOP00000025687 -------Q-YSLVE--DDEDL-----PHHDEKTWNVGSSNRNKAENLLRGK----------------RDGTFLVRES-SKQGCYACSVVVDGEVKHCV-INKTATGYGFAEPYNLYSSLK X_tropicalis_ENSXETP00000007065 -------T-YFVSE--EDDNL-----PHYDEKTWFVGDLNRIQAEELLSGK----------------PDGAFLIRES-SKKGCYACSVVADGDVKHCV-IYSTSRGYGFAEPYNLYSTLK A_carolinensis_ENSACAP00000015633 -------T-YFTNE--EDENL-----PHYDEKTWFVGDLNRIQAEDLLCGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTPRGYGFAEPYNLYSTLK R_norvegicus_ENSRNOP00000000157 -------G-YFINE--DDESL-----PHYDEKTWFVEDVNRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYGSLK G_aculeatus_ENSGACP00000006864 -------G-YFVSE--EDENL-----PHYDEKSWFVGDLNRTEAEDLLTGK----------------PDGAFLIRES-SKKGCYACSVIVEGEVKHCV-IYSTPRGFGFAEPYNLYSSLK C_familiaris_ENSCAFP00000006438 -------T-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK M_mulatta_ENSMMUP00000040267 -------N-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK B_taurus_ENSBTAP00000003878 -------T-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYGSLK P_pygmaeus_ENSPPYP00000001627 -------N-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK P_troglodytes_ENSPTRP00000001190 -------N-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK H_sapiens_ENSP00000361075 -------N-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK M_musculus_ENSMUSP00000030464 -------S-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK D_rerio_ENSDARP00000040333 -------A-YFVSE--EDENL-----PHYDEKSWFVGDLNRTQSEDLLHGK----------------PDGAFLIRES-SKKGCYACSVVVEGEVKHCV-IYSTPRGFGFAEPYNLYSTLK O_latipes_ENSORLP00000016725 -------S-SFVSE--EEENL-----PHYDEKSWFVGNLNRMEAEELLIGK----------------SDGVFLIRES-SKKGCYACSVVVDGEVKHCV-IYSTPRGFGFAEPYNLYSSLK T_rubripes_ENSTRUP00000000305 -------G-SCLSQ---EENL-----PHHDEKSWFVGDLNRTQAEELLQGK----------------PDGAFLIRES-SKKSCYACSVVVEGEVKHCV-VLSTPRGFGFAEPFNLYSSLK O_anatinus_ENSOANP00000009424 -------T-YFVNE--EDENL-----PHYDEKTWFVGDLNRTQAEDLLRGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTPRGYGFAEPYNLYGTLK X_tropicalis_ENSXETP00000028313 -------P-YSMM---DDEDL-----PHHEEHTWYMGKMKREQAEEMLAGK----------------PDGTFLIRVS-RQKGCYACSVVVDSDTKHCM-IYKAATGYGFAEPYNLYSSLK O_cuniculus_ENSOCUP00000012307 -------T-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK T_rubripes_ENSTRUP00000030226 -------T-YVLKG--DEKNL-----PHQDETYWFVGEMSRTQAEEMLQGK----------------DPGTFLIRES-SKQGSYACSVVVNEEVKHCM-IYRTPHGYGFAEPYDVHCSLK O_latipes_ENSORLP00000013359 -------T-YVLKG--DEKNL-----PHNDEASWFVGELSRTQAEEMLQDK----------------AAGTFLIRES-SKQGCYACSVVVNQEVKHCK-IYSTPHGYGFAEPYDIHCSLK G_aculeatus_ENSGACP00000021319 -------T-YVLKG--DEKNL-----PHQEEANWFVGELSRTQAEEMLQDK----------------APGTFLIRES-SKQGCYACSVVVNEEVKHCM-IYSTPQGYGFAEPYDAHCSLK T_nigroviridis_ENSTNIP00000009742 -------T-YVLKG--DEKNL-----PHQDETYWFVGEMSRTQAEEMLQGK----------------DPGTFLIRES-SKQGSYACSVVVNQEVKHCM-IYRTPHGYGFAEPYDVHCSLK G_aculeatus_ENSGACP00000010853 -------P-YTLAE--D---------PDQEERSWYVGGMRRREAEELLRGR----------------KDGTFLIRDSQTQRGSFACSVVVDGGVKHCV-IHRTSTGYGFAEPFNQHPTLR T_rubripes_ENSTRUP00000017331 -------P-YTLAD--D---------THQEERSWYVGNMKRKEAEELLKGR----------------RDGTFLIRDSQTQRGSFACSVVVNGDVKHCM-IYRTSTGYGFAEPYNLYSSLR T_nigroviridis_ENSTNIP00000013096 -------P-YTLAD--D---------SHQKESSWYGGSMKRKEAEELLKGR----------------RDGTFLIRDSQTQRGSFACSVVVNGDVKHCV-IYRTPAGYGFAEPYNLHASLR G_gorilla_ENSGGOP00000009961 -------N-YFINE--EDENL-----PHYDEKTWFVEDINRVQAEDLLYGK----------------PDGAFLIRES-SKKGCYACSVVADGEVKHCV-IYSTARGYGFAEPYNLYSSLK M_domestica_ENSMODP00000002600 -------T-YFMKE--EEENR-----PHKDEKTWFVGDLNRLQAEDLLHGK----------------PDGAFLIRES-SKKGCYACSVVADGDVKHCV-IYSTARGYGFAEPYNLYGTLK A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006602 -------S-SCL-------SL-----PHHDERSWFVGDLKRGEAEELLLGR----------------PDGSFLVRES-SRKGCYACSVVVEGVVTALRGAADADGGFGFAEPFDRHASLK D_rerio_ENSDARP00000089169 -------I-YFESG--CEELL--------REESWFVGDLARGPAEELLLGK----------------PNGAFLIRNS-SSKDCYACSVVVNSQVRHCV-IRHTERGYGFVEPFDLHKSLK A_aegypti_AAEL013596-PA -------Y-FSHSH--GSQEM-----PHNDESTWLVPTFNRTDAEKELASK----------------PNGTFVIRPG--SGGPYALSIKCNDTVNHCI-IQQTDRGYGFAEPYNIYDSLK C_intestinalis_ENSCINP00000004274 -------G-VYHLP--DSVNLREKYPDHCVETNWFFPRYGRREADEVLRGT----------------PNGTFLIRER-NGPPPYACSLVANGKVHHCL-IEQTDDGYGFAEPFNLHLTLS A_gambiae_AGAP005583-PA -------Y-LSTANPDGTQEL-----PHLDETTWLRERYSRQDAEKKLANK----------------PTGTFLIRAR--NAGHYALSIACDGRVNHCI-IHQTERGYGFAEPYYIYDSLK D_melanogaster_FBpp0077791 -------W-QQLYE--TVSNQ-----PHSNEALWLLKDAKRRNAEEMLKGA----------------PSGTFLIRAR--DAGHYALSIACKNIVQHCL-IYETSTGFGFAAPYNIYATLK T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 -------X-XXXXX--XXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXX----------------XXXXXXXXXX-XXXXXXXXXXXVDGEVKHCV-INKTATGYGFAEPYNLYSSLK C_elegans_Y110A7A.10 ---------TKVTQLLVDMEL-----KWTPAQYLMCGTSKENAANALIHARYRIAQLDKAVGLKREPQDGIFLIRGSSSHGDKLVLSVLHGERVSHCL-IEQNEEGWGFEHSNVYLTTIS T_guttata_ENSTGUP00000000990 -------V-ISTTE------------KPLAEQDWYHGAIPRIEAQELL--K----------------QQGDFLVRESHGKPGEYVLSVFSDGQRRHFI-IQYADNQYRFEG--TGFPTIP R_norvegicus_ENSRNOP00000021758 -------V-ISVGE------------KPLAEHDWYHGAIPRIEAQELL--K----------------QQGDFLVRESHGKPGEYVLSVYSDGQRRHFI-IQFVDNLYRFEG--TGFSNIP 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000018245 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000004228 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000003033 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000022072 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000034296 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000026210 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000010903 ELVLHYQHASLVQHNDSLTVTQAHPVR--------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000002082 DLVLHYKHTSLVQHNDSLNVTLAHPVL--------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000005414 DLVLHYKHTSLVQHNDSLNVTLAHPVL--------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000015802 ELVLHYQHASLVQHNDALTVTLAHPVR--------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002126 DLVLHYKHTSLVQHNDSLNVTLAHPVL--------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000000409 DLVLHYKHTSLVQHNDSLNVTLAHPV---------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000026404 DLVLHYKNVSLVQHNDHLNVTLAHPVL--------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000090206 DLVLHYKHTSLVQHNDSLNVTLAYPVL--------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000014006 DLVLHYKNVSLVQHNDHLNVTLAHPVL--------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000018794 ELVLHYQHTSLVQHNDSLNVTLAHPVY--------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000027602 ELVLHYQHTSLFQHNDSLNVTLAFPVY--------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000016070 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022063 ELVLHYQHTSLVQHNDSLNVTLAFPVY--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000020473 DLVLHYKNVSLVQHNDHLNVNLAYPVM--------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000015140 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000023822 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000056212 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000017836 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000024566 ELVLHYQHTSLVQHNDSLNVTLAYPVN--------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000017341 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000011322 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000001371 ELVLHYQHTSLVQHNDSLNVTLAFPVY--------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000021829 ELVLHYQHTSLVQHNDSLNVTLAFPVY--------------------------------------------------------------------------------------------- H_sapiens_ENSP00000379855 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000029009 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000003114 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000046442 ELVLHYQHTSLVQHNDSLNVTLANPVY--------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000014594 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000056774 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000020881 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- G_gallus_ENSGALP00000037576 DLVLHYQQTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- T_guttata_ENSTGUP00000008408 DLVLHYQQTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- E_caballus_ENSECAP00000007453 ELVLHYQHTSLLQHNDALAVTLAHPVR--------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000004433 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000003326 ELVLHYQHTSLVQHNDSLNVTLAYPVF--------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000025687 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000007065 ELVLHYQHTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000015633 ELVLHYQHTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- R_norvegicus_ENSRNOP00000000157 ELVLHYQQTSLVQHNDSLNVTLAYPVH--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000006864 DLVLHYRQASLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- C_familiaris_ENSCAFP00000006438 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- M_mulatta_ENSMMUP00000040267 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- B_taurus_ENSBTAP00000003878 ELVLHYQRTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- P_pygmaeus_ENSPPYP00000001627 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- P_troglodytes_ENSPTRP00000001190 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- H_sapiens_ENSP00000361075 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- M_musculus_ENSMUSP00000030464 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000040333 DLVLHYHQTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000016725 DLVLHYQQTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000000305 ELVLHYQQASLVQHNDSLNVRLSYPVY--------------------------------------------------------------------------------------------- O_anatinus_ENSOANP00000009424 ELVLHYQQTSLVQHNDSLNVRLAYPVY--------------------------------------------------------------------------------------------- X_tropicalis_ENSXETP00000028313 ELVLHYQHTSLVQHNDALNVTLSYPVL--------------------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000012307 ELVLHYQHTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000030226 DLVLHYRLHSLAQHNDALDVRLSHPVH--------------------------------------------------------------------------------------------- O_latipes_ENSORLP00000013359 DLVLHYRLHSLAQHNDALDVRLSHPVN--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000021319 DLVLHYRLHSLAQHNDALDVRLSHPVH--------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000009742 DLVLHYRLHSLAQHNDALDVRLSHPVH--------------------------------------------------------------------------------------------- G_aculeatus_ENSGACP00000010853 ELVLHYRHTSLIQHNQQLNVTLAWPAL--------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000017331 DLVLHYRHTSLIQHNQQLNVTLAWPAL--------------------------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000013096 DLVLHYRHTSLVQHNQQLNVTLAWPAL--------------------------------------------------------------------------------------------- G_gorilla_ENSGGOP00000009961 ELVLHYQQTSLVQHNDSLNVRLAYPVH--------------------------------------------------------------------------------------------- M_domestica_ENSMODP00000002600 ELVLHYQHTSLVQHNDSLNVRLAHPVY--------------------------------------------------------------------------------------------- A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006602 ELVLHYRRASLAQHNRALDVRLAFPVH--------------------------------------------------------------------------------------------- D_rerio_ENSDARP00000089169 DLVLHYSQTSLAQHNQALDVRLAYPVH--------------------------------------------------------------------------------------------- A_aegypti_AAEL013596-PA SLVLHYATNSLEEHNDTLQTTLKYPLL--------------------------------------------------------------------------------------------- C_intestinalis_ENSCINP00000004274 DLVLHYAHNSLIPHNETLDTKLSIPVG--------------------------------------------------------------------------------------------- A_gambiae_AGAP005583-PA SLVVHYATNSLEEHNDLLQTTLKYPAF--------------------------------------------------------------------------------------------- D_melanogaster_FBpp0077791 SLVEHYANNSLEEHNDTLTTTLRWPVLYWKNNPLQVQMIQLQEEM--------------------------------------------------------------------------- T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 ELVLHYQHTSLVQHNDSLNVTLAYPVY--------------------------------------------------------------------------------------------- C_elegans_Y110A7A.10 DFVRYYSHFSLETHADAIKTPLRTPAFDAVTSDTSKPLRNGPGQVFTAL----------------------------------------------------------------------- T_guttata_ENSTGUP00000000990 QLIEHHYTTKQVITKKS-GVVLLNPVVKDKKWVLSHEDVTLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGD R_norvegicus_ENSRNOP00000021758 QLIDHHFNTKQVITKKS-GVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGD 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000222254 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000018245 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000004228 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003033 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000022072 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000034296 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000026210 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000010903 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002082 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000005414 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000015802 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002126 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000409 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000026404 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000090206 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000014006 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000018794 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000027602 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000016070 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000022063 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000020473 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015140 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023822 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000056212 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000017836 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000024566 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000017341 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000011322 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000001371 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000021829 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000379855 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000029009 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000003114 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000046442 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000014594 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000056774 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000020881 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000037576 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000008408 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000007453 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000004433 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003326 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000025687 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000007065 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015633 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000000157 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000006864 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000006438 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040267 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003878 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000001627 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000001190 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000361075 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030464 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000040333 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000016725 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000000305 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000009424 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000028313 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000012307 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000030226 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000013359 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000021319 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009742 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000010853 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000017331 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013096 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000009961 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000002600 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000006602 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000089169 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL013596-PA ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000004274 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP005583-PA ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0077791 ----------------------------------------------------------------------------------------------------------------------DL T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000004170 ------------------------------------------------------------------------------------------------------------------------ C_elegans_Y110A7A.10 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000000990 FLSFLRKKKDELKTKQLVKFSLDAASGMAYLESKNCIHRDLAARNCLVGESNILKISDFGMSRQEDDGVYSSSGLKQIPIKWTAPEALNYGRYTSESDVWSFGILLWETFSLGVCPYPGM R_norvegicus_ENSRNOP00000021758 FLSFLRKRKDELKLKQLVRFSLDVAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 1330 1340 1350 1360 1370 1380 =========+=========+=========+=========+=========+=========+= H_sapiens_ENSP00000222254 ----APGP--GPPPAAR-------------------------------------------- P_troglodytes_ENSPTRP00000018245 ----APGP--GPPPAAR-------------------------------------------- M_mulatta_ENSMMUP00000004228 ----APGP--GPPPAAR-------------------------------------------- B_taurus_ENSBTAP00000003033 ----APGP--GPPPAAR-------------------------------------------- C_familiaris_ENSCAFP00000022072 ----APGP--GPPPATR-------------------------------------------- M_musculus_ENSMUSP00000034296 ----APGP--GPPSAAR-------------------------------------------- R_norvegicus_ENSRNOP00000026210 ----APGP--GPPPAAR-------------------------------------------- P_pygmaeus_ENSPPYP00000010903 ----APGP--GPPPAAR-------------------------------------------- O_anatinus_ENSOANP00000002082 ----SPPP--AHPPALR-------------------------------------------- G_gallus_ENSGALP00000005414 ----SQPP--AR------------------------------------------------- G_gorilla_ENSGGOP00000015802 ----APGP--GPPPAAR-------------------------------------------- M_domestica_ENSMODP00000002126 ----SPPP--AR------------------------------------------------- T_guttata_ENSTGUP00000000409 ------------------------------------------------------------- T_rubripes_ENSTRUP00000026404 ----ARSQ--NQNQHPR-------------------------------------------- D_rerio_ENSDARP00000090206 ----AQQP--R-------------------------------------------------- T_nigroviridis_ENSTNIP00000014006 ----ARSQ--N-------------------------------------------------- T_rubripes_ENSTRUP00000018794 ----AQQK--RPPPPAE-------------------------------------------- T_rubripes_ENSTRUP00000027602 ----RSGP--GPQSGPK-------------------------------------------- A_carolinensis_ENSACAP00000016070 ----AQQR--R-------------------------------------------------- T_nigroviridis_ENSTNIP00000022063 ----SPQR--R-------------------------------------------------- G_aculeatus_ENSGACP00000020473 ----APSQ--N-------------------------------------------------- M_mulatta_ENSMMUP00000015140 ----AQQR--R-------------------------------------------------- G_gallus_ENSGALP00000023822 ----AQQR--R-------------------------------------------------- D_rerio_ENSDARP00000056212 ----GHQR--R-------------------------------------------------- E_caballus_ENSECAP00000017836 ----AQQR--R-------------------------------------------------- M_domestica_ENSMODP00000024566 ----AQQR--R-------------------------------------------------- P_pygmaeus_ENSPPYP00000017341 ----AQQR--R-------------------------------------------------- C_familiaris_ENSCAFP00000011322 ----AQQR--R-------------------------------------------------- G_aculeatus_ENSGACP00000001371 ----SQPR--R-------------------------------------------------- O_latipes_ENSORLP00000021829 ----SQQR--R-------------------------------------------------- H_sapiens_ENSP00000379855 ----AQQR--R-------------------------------------------------- P_troglodytes_ENSPTRP00000029009 ----AQQR--R-------------------------------------------------- T_guttata_ENSTGUP00000003114 ----AQQR--R-------------------------------------------------- X_tropicalis_ENSXETP00000046442 ----AQQR--R-------------------------------------------------- B_taurus_ENSBTAP00000014594 ----AQQR--R-------------------------------------------------- M_musculus_ENSMUSP00000056774 ----AQQR--R-------------------------------------------------- G_aculeatus_ENSGACP00000020881 ----TQQR--R-------------------------------------------------- G_gallus_ENSGALP00000037576 ----AQMP--P-------------------------------------------------- T_guttata_ENSTGUP00000008408 ----AQMP--P-------------------------------------------------- E_caballus_ENSECAP00000007453 ----APAP--AP------------------------------------------------- O_cuniculus_ENSOCUP00000004433 ----AQQR--R-------------------------------------------------- O_latipes_ENSORLP00000003326 ----THQR--R-------------------------------------------------- R_norvegicus_ENSRNOP00000025687 ----AQQR--R-------------------------------------------------- X_tropicalis_ENSXETP00000007065 ----AQMP--SLCR----------------------------------------------- A_carolinensis_ENSACAP00000015633 ----AQMS--SLCR----------------------------------------------- R_norvegicus_ENSRNOP00000000157 ----AQMP--SLCR----------------------------------------------- G_aculeatus_ENSGACP00000006864 ----AQMP--SGRR----------------------------------------------- C_familiaris_ENSCAFP00000006438 ----AQMP--SLCR----------------------------------------------- M_mulatta_ENSMMUP00000040267 ----AQMP--SLCR----------------------------------------------- B_taurus_ENSBTAP00000003878 ----AQMP--SLCR----------------------------------------------- P_pygmaeus_ENSPPYP00000001627 ----AQMP--SLCR----------------------------------------------- P_troglodytes_ENSPTRP00000001190 ----AQMP--SLCR----------------------------------------------- H_sapiens_ENSP00000361075 ----AQMP--SLCR----------------------------------------------- M_musculus_ENSMUSP00000030464 ----AQMP--TLCR----------------------------------------------- D_rerio_ENSDARP00000040333 ----AQMP--SGPRR---------------------------------------------- O_latipes_ENSORLP00000016725 ----TQMP--SGRR----------------------------------------------- T_rubripes_ENSTRUP00000000305 ----AQMP--PGRR----------------------------------------------- O_anatinus_ENSOANP00000009424 ----AQMP--ALGR----------------------------------------------- X_tropicalis_ENSXETP00000028313 ----APPP--RFQSP----SPTRV------------------------------------- O_cuniculus_ENSOCUP00000012307 ----AQMP--SLCR----------------------------------------------- T_rubripes_ENSTRUP00000030226 ----AKSP--ATPPQ---------------------------------------------- O_latipes_ENSORLP00000013359 ----AKDA--TAAAS---------------------------------------------- G_aculeatus_ENSGACP00000021319 ----AEPA--AVTPSQ--------------------------------------------- T_nigroviridis_ENSTNIP00000009742 ----AKSP--ATPTR---------------------------------------------- G_aculeatus_ENSGACP00000010853 ----SQQP--RLTK----------------------------------------------- T_rubripes_ENSTRUP00000017331 ----SQQP--RYCR----------------------------------------------- T_nigroviridis_ENSTNIP00000013096 ----SQQP--SLCV----------------------------------------------- G_gorilla_ENSGGOP00000009961 ----AQMP--SLCR----------------------------------------------- M_domestica_ENSMODP00000002600 ----AQLP--SHC--------R--------------------------------------- A_carolinensis_ENSACAP00000012532 ------------------------------------------------------------- T_nigroviridis_ENSTNIP00000006602 ----AHTP--SGRGV----RPRPR------------------------------------- D_rerio_ENSDARP00000089169 ----MSSV--PTV------------------------------------------------ A_aegypti_AAEL013596-PA ----APTR--QQST----------------------------------------------- C_intestinalis_ENSCINP00000004274 ----CVHR----R------------------------------------------------ A_gambiae_AGAP005583-PA ----APNM--PSGSG----SGSGSGSGSGSGQTSGGGGGGGGGSSSSRQQGSAPWSTSFAA D_melanogaster_FBpp0077791 EYEQAATL--RPPPM----MGSSAPIPTSRSREHDVVDGTGSLEAEAAPASISPSNFSTSQ T_nigroviridis_ENSTNIP00000022692 ------------------------------------------------------------- G_gorilla_ENSGGOP00000004170 ----AQQR--R-------------------------------------------------- C_elegans_Y110A7A.10 ----PISRKYMEKALLTDDPTKPPESPEPRPDSWDSPSPDTPSSSDSRLVHPTTLPKSIPE T_guttata_ENSTGUP00000000990 TNQQAREQ--VEKGYRMSAPQKCPEEIYKIMQRCWDYKPENRPKFSEIQKELSSIKKKVT- R_norvegicus_ENSRNOP00000021758 TNQQAREQ--VERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELTAIKKKIT-