10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221132 MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD--- P_pygmaeus_ENSPPYP00000020658 MAPPPAGIKLGAFLAVTPNPGSAESETEAAAATPSKVWSSSAGRTEPRGGGRGALPTPMGQHGPSARARAGRAPGPRPARGASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD--- P_troglodytes_ENSPTRP00000034378 MAPPPAGVNLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGREALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD--- G_gorilla_ENSGGOP00000002136 MAPPPAGIKLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEARGGGRGALPTPMGQHGPSARARAGRAPGHRPAREAIPRLRVHKTFKFVV--VGVLLQVVPSSAATIKLHD--- M_mulatta_ENSMMUP00000021894 --------------------------------------------------------------------------------------------------------VVPGSAATIKVHD--- P_troglodytes_ENSPTRP00000034375 M----------------EQRGQNAP---AASG-----------------------------------ARKRHGPGPREARGARPGLRVPKTLVLIV--AAVLL-LVSAESALITQQDLAP H_sapiens_ENSP00000276431 M----------------EQRGQNAP---AASG-----------------------------------ARKRHGPGPREARGARPGPRVPKTLVLVV--AAVLL-LVSAESALITQQDLAP P_pygmaeus_ENSPPYP00000020655 M----------------EQRGQNAP---AASG-----------------------------------ARKRRGPGPREVRGAGPGLRVPKTLVLVV--AAVLL-LVSAESALITQQDLVP E_caballus_ENSECAP00000022015 MTLPGVTQRRPELGALPNPAGQRGPSALAASG-----------------------------------APAGCAPGPRPA-------PGPRTLIFV---LGTLL-LGPAASAMIIRQERVH M_mulatta_ENSMMUP00000021892 M----------------GLCGQSAP---TASS-----------------------------------ARAGRSPGARTASGTTPWLPDPKTLKFVFVVVAVLL-PAQVDSATISRKDEVP H_sapiens_ENSP00000310263 M----------------GLWGQSVP---TASS-----------------------------------ARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLL-PVRVDSATIPRQDEVP G_gorilla_ENSGGOP00000010773 M----------------EQRGQNAP---AASG-----------------------------------ARKRHGPGPREARGARPGLRVPKTLVLVV--VAVLL-LVSAESALITQEDLAP P_troglodytes_ENSPTRP00000034377 M----------------GLWGQSVP---TASS-----------------------------------ARAERYPGARTASGTRPWLLDPKTLKFVVFIVAVLL-PVRVDSATIPGQDEVP G_gorilla_ENSGGOP00000007840 M----------------GLWGQSVP---TASS-----------------------------------ARAERYPGARTASGTRPWLLDPKTLKFVVFIVAVLL-PVRVVSATIPRQDEVP P_pygmaeus_ENSPPYP00000020657 L----------------GLWEQSAL---TTMR-----------------------------------APVGRYLAARTASGTRPWLPGPKTLKFVVLIVAVLL-PVYVYSATIPRQDEAP M_musculus_ENSMUSP00000022663 M----------------EPPGPSTP---TASA-----------------------------------A-------ARADHYTPGLRPLPKRRLLYS--FALLL-AVLQAVFVPVTANPAH G_gorilla_ENSGGOP00000010787 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034372 M----------------RLWGQSAP---TASS-----------------------------------VGAGRYPGARTASGTRRRLPGPKTLKFLV-FVAVLP-RVQVDSATIRPQDEAP R_norvegicus_ENSRNOP00000055444 -----------------------------------------------------------------------------------------------------------QSFFVPVTAKLAQ G_gallus_ENSGALP00000000612 L-----------------------------------------------------------------------------------RTPLGQCPLLVPLFAEVQLG----------SAAAVK O_anatinus_ENSOANP00000021880 L----------------------------------------------------------------------------------------------------------------------- T_rubripes_ENSTRUP00000013812 S-------------------------------------------------------------------------------------------------QMIQVLLLAVLCGLQCGAVEPP G_gallus_ENSGALP00000038567 M-----------------------------------------------------------------------------------------GLRAVGLLLLVTLL----------TVPGSD T_nigroviridis_ENSTNIP00000001044 --------------------------------------------------------------------------------------------------QMIQVLLLAVVCGLKSGAVEPP M_domestica_ENSMODP00000011508 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000012354 M-------------------------------------------------------------------------------------------RYITLLVLLLLNVINAARSHGDLAWAHR O_latipes_ENSORLP00000003602 S-----------------------------------------------------------------------------------------------------TQVVALFAGLVCHAAEPP G_aculeatus_ENSGACP00000007142 M----------------------------------------------------------------------------------------VSVKSVFCILIVFLK----------PSGAFP O_latipes_ENSORLP00000020293 --------------------------------------------------------------------------------------------------ITLILQTTKSQVVKLTAANLPP G_aculeatus_ENSGACP00000020911 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000023053 M------------------------------------------------------------------------------APRGESTGYAPMAKLTLCFFCIFLL----------AAPITN T_guttata_ENSTGUP00000013762 M--------------------------------------------------------------------------------RSPALPRTSLRTVILIFVCVLTKESVEITPVPYRLQVRQ O_anatinus_ENSOANP00000029006 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000018492 M-----------------------------------------------------------------------EPLPGWESSPWSRA--DNTFRLVPCVFLLNL-----------LQCISA G_gallus_ENSGALP00000023975 M--------------------------------------------------------------------------------RGLALPRSSLGTVILTFVCVLVEESVGIAPVPYMLQLRR M_musculus_ENSMUSP00000045240 M-----------------------------------------------------------------------EPLPGWGSAPWSQAPTDNTFRLVPCVFLLNL-----------LQRISA 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221132 -QSIGTQ--------------------QWEHSPLGELCP--PGSHR------SEHPGACNRCTEGVGYTNASN-NLFACLPCTACKS-------DE--EERSPCTTTRNTACQCKPGTFR P_pygmaeus_ENSPPYP00000020658 -QSVGTQ--------------------QWEHSPLGELCP--PGSHR------SEHPGACNRCTEGVGYTNASN-NLFACLPCTACKS-------DE--EERSPCTTTRNTACQCKPGTFR P_troglodytes_ENSPTRP00000034378 -QSIGTQ--------------------QWEHSPLGELCP--PGSHR------SEHPGACNQCTEGVGYTNASN-NLFACLPCTACKS-------DE--EERSPCTTTSNTACQCKPGTFR G_gorilla_ENSGGOP00000002136 -QSIGTQ--------------------QWEHSPLGELCP--PGSHR------SEHPGACNRCTEGVGYTNASN-NLFACLPCTACKS-------DE--EERSPCTTTRNTACQCKPGTFR M_mulatta_ENSMMUP00000021894 -QSVGTQ--------------------QWEHSPLGELCP--PGSHR------SEDSGACNQCTEGVGYTSASN-NLFSCLPCTACKS-------DE--EERSACTRTRNTACQCKPGTFR P_troglodytes_ENSPTRP00000034375 QQRAAPQ--------------------QKRSSPSEGLCP--PGHHI------SEDSRDCISCKYGQDYSTHWN-DLLFCLRCTRCDS-------GE--VEVSPCTTTRNTACQCEEGTFR H_sapiens_ENSP00000276431 QQRAAPQ--------------------QKRSSPSEGLCP--PGHHI------SEDGRDCISCKYGQDYSTHWN-DLLFCLRCTRCDS-------GE--VELSPCTTTRNTVCQCEEGTFR P_pygmaeus_ENSPPYP00000020655 QQRAAPQ--------------------QKRSSPSEGL------HHI------SEDSRDCISCKYGQDYSTHWN-DLLFCLRCTKCDS-------GE--VEVSPCTTTRNTVCQCEEGTFR E_caballus_ENSECAP00000022015 QQLAAPQ--------------------------MSTKCP--AGYHV------SEDSRSCTPCTDGVDYTSHKN-LFSSCLPCSTCKS-------DE--ERIADCTRTEDTQCRCKRGTFH M_mulatta_ENSMMUP00000021892 LPPVASK--------------------QQRRSL-EAECP--AGFHR------SEHTGACNPCTEGVDYTIASN-NLPSCLLCTVCKS-------GQ--TNTSSCTTTRDTVCQCEKGSFQ H_sapiens_ENSP00000310263 QQTVAPQ--------------------QQRRSLKEEECP--AGSHR------SEYTGACNPCTEGVDYTIASN-NLPSCLLCTVCKS-------GQ--TNKSSCTTTRDTVCQCEKGSFQ G_gorilla_ENSGGOP00000010773 QQRAAPQ--------------------QKRSSPSEGLCP--PGHHI------SEDGRDCISCKYGQDYSTHWN-DLLFCLRCTRCDS-------GE--VEVSPCTTTRNTVCQCEEGTFR P_troglodytes_ENSPTRP00000034377 QQTVAPQ--------------------QQRRSLKEEECP--AGSHR------SEYTGACNPCTEGVDYTIASN-NLPSCLPCTVCKS-------GQ--TNKSSCTTTRDTVCQCEKGRFQ G_gorilla_ENSGGOP00000007840 QQTVAPQ--------------------QQRRSLKEEECP--AGSHR------SEYTGACNPCTEGVDYTIASN-NLPSCLPCTVCKS-------GQ--TNKSSCTTTRDTVCECEKGRFQ P_pygmaeus_ENSPPYP00000020657 QQTVAPQ--------------------QQRRSLKEEECP--AGSHR------SEHTGACNPCTEGVDYTIASN-NLPSCLLCTVCKS-------GQ--TTKSSCTTTRDTMCQCEKGSFQ M_musculus_ENSMUSP00000022663 NRPAGLQ--------------------RPEESPSRGPCL--AGQYL------S--EGNCKPCREGIDYTSHSNHSLDSCILCTVCKE-------DK--VVETRCNITTNTVCRCKPGTFE G_gorilla_ENSGGOP00000010787 -------------------------------------------SHR------SEHTGACNPCXEGVDYTNASX-NXPSCFPCTVCK--------XE--KEMSPCTTTGNTVCQCEPGSFW P_troglodytes_ENSPTRP00000034372 QQTAAPQ--------------------EERRSLKEKKCP--A-SHR-----------ACNPCREGVDYTNASN-NAPSCFPCTVCKS--------E--KEMSPCTTTRNTVCQCEPGSFW R_norvegicus_ENSRNOP00000055444 DRPADLQ--------------------RLKQSPLECPAV--SGQYL------SKEDGSCKACIDGENYTSGPN-VLPSCLSCRVCKEGLSHVVNRK--YPSVRCART----CHIWSAAFS G_gallus_ENSGALP00000000612 KRADRSD--------------------LQKPDLYRRKCP--MGTY------EANDSIQCLPCKKD-EYTEYPN-DFPKCLGCRTCRE-------DQ--VEVSPCIPTRNTQCACKNGTFC O_anatinus_ENSOANP00000021880 ------------------------------------HFP--SGQYVKEGCNTSFTHGICAPCQNGANFTAFPN-GLFYCIKCQICKP-------DQ--EEVSPCTTTEDTQCHCKAGTFC T_rubripes_ENSTRUP00000013812 ASQWSRKEHQNLTVRQHR-NCVENEQ-YLHQGFCCLNCR--AGTFVYKECERDQEQGVCHSCEHGQTYTEHSN-GMNRCLPCTHCRL-------DE--IETASCTTTSDTRCQCKPGTFC G_gallus_ENSGALP00000038567 AEVCGEGE-------------------YLYEDICCMLCP--AGTYVAQHCRIPHSRGKCASCTEGRDYTAHAN-GLEECLLCRQCKD-------DQ--ITLRTCTVTSDTECQCHQGYFC T_nigroviridis_ENSTNIP00000001044 ASQWSRNEFQNLTLRQHR-TCVENEQ-YYYQGLCCLNCQ--AGTFVHKGCDRDQERGLCLPCEHGQTYTEHSN-GMHGCLPCTRCRT-------DE--IETASCTTTSDTRCQCKLGTFC M_domestica_ENSMODP00000011508 ---------------------------------------------------------------------------------------------------ETVPCHATHNTKCQCRSGTFC D_rerio_ENSDARP00000012354 SVKNRLS---------RDVSCREGLE-YPHENICCLNCP--AGTYVKKACAAAAEKGVCAPCEFD-TYTEHDH-GLLKCISCDKCRI-------DQ--ETIEKCTSTQNTRCKCRNGSFC O_latipes_ENSORLP00000003602 ASQRSAGVHRNATLRQHQAQCVENQQ-YPHQGLCCLNCQAVAGTFVKKPCERDQQQGICEPCEHGQTHTEHSN-GMGRCLPCNHCRQ-------DQ--IEVAACTVTTNTRCQCKPGTFC G_aculeatus_ENSGACP00000007142 QPKCKDGL-------------------ENTNGVCCSKCP--AGKRQASPCTQHGEEGKCEECDDG-TFIEHAN-VLHHCLKCTQCRP--E----DQ--EVVRQCTHTQDGECQCKAGGFC O_latipes_ENSORLP00000020293 GLRVRR---------RRHFGACGEQE-YPNGNICCLNCK--AGTFVKSSCTAAGQRGTCEECDYG-TFTEHDN-HLQKCVDCAKCGP-------DQ--EVAEQCTNTQNTKCRCKAGRFC G_aculeatus_ENSGACP00000020911 -----------------------------------------AGTFVHKGCERDQESGSCVACEDGRAYTEHSN-GMSRCLPCTHCRS-------DE--IRTASCTTTTDTSCQCRQGTFC X_tropicalis_ENSXETP00000023053 GLPLSSDLY------------------YQEGNIRCLRCP--AGTFVEKPCTKPDTIGECSSCHTGSTYSEGPT-GLDHCLTCLRCRD-------DQ--EEVRPCTATQNAECRCKKGTYC T_guttata_ENSTGUP00000013762 VALDGRDPSNPLRREKKQMHCQLGQYLHPRKTHCCMRCH--AGTYKAKDCDGPDQATVCLPCSNG-TFTAVDN-TMSKCFQCKRCRTAL-----QQ--IVETPCTPKQDTVCGCQKNQYQ O_anatinus_ENSOANP00000029006 --------------------------------------------------------GRCEPCRPG-EFTAHPN-GLYACRPCKQCHPE------DK--VTVAPCTRFSDTRCQCKPNHYC R_norvegicus_ENSRNOP00000018492 QPLCRQEE-------------------FSVGDECCPMCN--PGYHVKQVCS-EHTGTVCAPCPPQ-TYTAHAN-GLSKCLPCGVCDP-------DMGLLTWQECSSWKDTVCRCISGYFC G_gallus_ENSGALP00000023975 ATLDGRDPFNRLRREKRQVQCQLGQYLHPKGTHCCMRCH--AGTYKLKDCEWSGQAPVCLPCPNG-TFTAVDN-IMEKCFQCTRCRTEL-----QQ--IEKTPCTQKQDTVCGCRKNQYQ M_musculus_ENSMUSP00000045240 QPSCRQEE-------------------FLVGDECCPMCN--PGYHVKQVCS-EHTGTVCAPCPPQ-TYTAHAN-GLSKCLPCGVCDP-------DMGLLTWQECSSWKDTVCRCIPGYFC 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221132 N-DNSA-EMCRKC--SRGCPRGMVK-VKDCTPWSDIECVHKESGN--------------------------------GHNIWVIL---VVTL-VVPLLLVAVLI------------VCCC P_pygmaeus_ENSPPYP00000020658 N-DNSA-EMCRKC--STGCPRGMVK-VGDCTPWSDIECVHKESGN--------------------------------GHNVWVIL---AVIL-IVLLLLVAVVI------------ACCC P_troglodytes_ENSPTRP00000034378 N-DNSA-EMCRKC--STGCPRGMVK-VKDCTPWSDIECVHKESGN--------------------------------GHNVWVIL---VVTLVVVPLLLVAVLI------------VCCC G_gorilla_ENSGGOP00000002136 N-DNSA-EMCRKC--STGCPRGMVK-VKDCTPWSDIECVHKESGN--------------------------------GHNVWVIL---VVTL-VVPLLLVAVLI------------VCCC M_mulatta_ENSMMUP00000021894 N-DDSA-EMCRKC--STGCPRGKVK-VKDCTPWSDIECVHNESGN--------------------------------GHNVWAILIVIVVIL-VVLLLLVAVLM------------FCRR P_troglodytes_ENSPTRP00000034375 E-EDSP-EMCRKC--RTRCPRGMVK-VGDCTPWSDIECVHKESGT--------KHTGEAPAVEETVTTSPGTPAS-PCSLSGIII---GVAV-AAVVLIVAVFV-CKSLLWKKVLPYLKG H_sapiens_ENSP00000276431 E-EDSP-EMCRKC--RTGCPRGMVK-VGDCTPWSDIECVHKESGT--------KHSGEVPAVEETVTSSPGTPAS-PCSLSGIII---GVTV-AAVVLIVAVFV-CKSLLWKKVLPYLKG P_pygmaeus_ENSPPYP00000020655 E-EDSP-EMCRKC--RTGCPRGMAK-VGDCTPWSDIECVHKE--------------------------------------SGIII---GVTV-LVVVLIVAVFA-CTSSLWKKVLPYLKG E_caballus_ENSECAP00000022015 G-EDFP-EVCQTC--RSRCPDGMVE-AGPCTPWSDLKCVHQGSGT--------QASGEAPVPGEPVTVGLPTTPSRSSGNPWPVI---GIVA-VAVAVAVLLLG-LTVYLYRRRI--LQG M_mulatta_ENSMMUP00000021892 D-ANSP-EMCRKC--STGCPRGMIK-VSDCTPWSDINC-SASAAS---------STGKTPAAEDTVPTSLGTPDL--YGLIAGVV--------TVFIILFAAAF-VCILRRKKLISSLKG H_sapiens_ENSP00000310263 D-KNSP-EMCRTC--RTGCPRGMVK-VSNCTPRSDIKCKNESAAS---------STGKTPAAEETVTTILGMLAS--PYHYLIII--------VVLVIILAVVV-VGFSCRKKFISYLKG G_gorilla_ENSGGOP00000010773 E-EDSP-EMCRKC--RTGCPRGMVK-VGDCTPWSDIECVHKESGT--------KHTGEAPAVEETVTTSPGTPAS-PCSLSGIII---GVAV-AAVVLIVAVFV-CKSLLWKKVLPYLKG P_troglodytes_ENSPTRP00000034377 D-KNSP-EMCRTC--RTGCPRGMVK-VSNCTSQSDIKCKNESAAS---------STGKTPAAEETVTTILGMLAS--TYHYLIII--------VVLVIILAVVV-VCILCRKKFISYLKG G_gorilla_ENSGGOP00000007840 D-KNSP-EMCRKC--RTGCPRGMVK-VSNCTSQSDIKCKNESAAS---------STGKTPAAEETVTTILGMLAS--TYHYLIII--------VVLVIIFAVVV-VGFSCRKTFISYLKG P_pygmaeus_ENSPPYP00000020657 D-ENTP-EMCQKC--RTGCPRGMVK-VRNCTSQSDIKCKNESAAS---------STGKTPAAEDTVTTSLGTLASPCCLAAIIIG--------ILVSIPVAAGL-VYILRRKKLISYLKG M_musculus_ENSMUSP00000022663 D-KDSP-EICQSC---SNCTDGEEE-LTSCTPRENRKCVSKTAWA-------------------------------SWHKLGLWI---GLLV-PVV-LLIGALLVWKTGAWRQWLLCIKR G_gorilla_ENSGGOP00000010787 N--NST-EMCRKC--RTECPRRMEK-VSDCTXWSDIXCKNESAAS---------STGKTPAAEETVTTILGMLAS--XSRLLIII--------XGSVIIFAVVV-VGFLCLKKFISYLKG P_troglodytes_ENSPTRP00000034372 N--DST-EMCRKC--RTECPRGMEK-VSDCTPLSDINCKNESAAS---------STGKTPAAEETVTTILGMLAS--PYLYLII------------IVVLAVVV-ICILCRKKFMSYLKG R_norvegicus_ENSRNOP00000055444 Q----NLIICFLC--VPSCTDGEDE-VIPCTPKANRKCVPKNTQI-------------------------------PQHNLGLII---GLLA-SVISVVLFVAVIWKTKAWESVCLFMTR G_gallus_ENSGALP00000000612 L-PDHPCEMCQKC--QTECPKGQVR-LAPCTQHSDLLCGPPLEIS---------------------------------SSSSXLL---QVITFTVLLAVILGLVLVFWKRCSSRHHGA-- O_anatinus_ENSOANP00000021880 P-RDHPCEVCMKC--KTRCPEDMAV-GSSCQPWSDLQCVPSERTV----------------------------------PRQLWI---LSAL-PLFLLLVAGLALGRYYLCNSSAGGSIS T_rubripes_ENSTRUP00000013812 V-PDQACEVCKRC--AK-CKAGEEE-VKKCTPSSNTECRKHNLPS-------------------------------PATVVSVIV--------VLLVLVLIGLAVWWFKQHPGET--GIR G_gallus_ENSGALP00000038567 P--AEGCEICQRC--TETCPEGREI-VQICNATMDLGCGLPDQGN--------------------------------KYFAWMII---GIFA-AVGFAGLLAF--CAIRKCKSAKATLSD T_nigroviridis_ENSTNIP00000001044 V-PDQACEVCKRC--AK-CKAGEEE-VEKCTPSSNTVCRKRDPSP--------------------VEPSQASPTPNPSSTLKTVI---FAVLGVVLFLLLLGLAAWRFRQRFV----AIK M_domestica_ENSMODP00000011508 P-KEHPCEICRKC--TSECPREMVE-KNPCSPSSDLECQEPTGTPTGHRDGCQEMGGQSPHTHQWVCQRV---------SIEVSL---DVAV-PMLFSHWIIVKFNLYWVLSVFLPFSAS D_rerio_ENSDARP00000012354 L-PDQACEVCKKC--SR-CKEDEET-EKSCTAISNTVCRKRSSPG------------------------------SSTSMTFIVI---MPLI-VLLACVLCIV--YWTKSKQNKTAAPVT O_latipes_ENSORLP00000003602 A-PEQACEVCKRC--AKRCKAGEEE-VKKCTPFSNTVCQKRGPSS------------------TEPAPVRPSPTSASASQTHLVL---YVFL-LLLVAIIVGVAIWWFKGRPS----CQT G_aculeatus_ENSGACP00000007142 A-PDQPCEVCRKC--SR-CKKDEVM-VRNCTATSNTECKKGQLDA------------------------------SPASGNALWW---LPVL-VIGVFVAIGVLGCFVLKRRTATGEYSD O_latipes_ENSORLP00000020293 N-PEEACEVCRKC--LT-CKSDEEI-VRNCTFTSNTVCKKIPLKP-----------------------------GSSLDAVFFVL---CVIP-VVLFLVAGGIF---LKYKKKCGCRGFQ G_aculeatus_ENSGACP00000020911 V-PDQACEVCKRC--AK-CKSGEEE-VKKCTPISNTECRKRDLSP--------------------TTSVTDAKASCSTSQVAPVW---ISLI-VIAIAIAAALAVWWLLVKRRSC--SRS X_tropicalis_ENSXETP00000023053 P-IDHPCEVCLTC--TEKCPPGQEL-QFPCNSTSDSQCGPAESGS-------------------------------WIVWLWLVL--------PLLLLVLIVVVLCKCRKQCKDDLCCV- T_guttata_ENSTGUP00000013762 IDSDSEYFQCRNC--SS-CADGT---IASCSKNKDAICRCKPQFFLSRNNICKPCNSCTGEDCLLCPSPVTTSPTSSGLNGNLVL---GTLV-AIFGVIFVLCVARKVGKLVQKDKIVSS O_anatinus_ENSOANP00000029006 E--LPACEVCLPC--RRTWGTGTASALTSRLPRRLVRCLALSHTT---------------------------------YSIWSVL---GVVAIVVVVVLLIGTVAFFLTSRCRSQLTPPS R_norvegicus_ENSRNOP00000018492 E-NQDG-GACSTCLPHAACPPGQRV-QKRGTYSHDTVCADCLTGTFSLGGTQEECLPWTKCSTFQREVKHGTSSTDTTCSFQ-TF---YIVV-VIVGVAIVGAGVVVFLLRKQ------- G_gallus_ENSGALP00000023975 F-GEADFFQCKNC--SS-CANGI---ITNCSKNSDAVCRCKPMFFMTLNNVCKHCNSCVGEECLQCSSPVTTSPNSSELNGNLVL---GIIV-AIFVVICVIYVVNKAVKLVQKNGIASS M_musculus_ENSMUSP00000045240 E-NQDG-SHCSTCLQHTTCPPGQRV-EKRGTHDQDTVCADCLTGTFSLGGTQEECLPWTNCSAFQQEVRRGTNSTDTTCSSQVVY---YVVS-ILLPLVIVGAGIAGFLICTR------- 370 380 390 400 410 420 430 440 450 460 470 480 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221132 IGSGCG----GDPKCMDRVCFW-RLGLLRG--PGAE--------------------DNAHNEIL-SNADSLSTFVSEQQMESQEPADLT-----------------------------GV P_pygmaeus_ENSPPYP00000020658 ISSGCG----VDPKCMDRMCFW-CLRLLRE--PGAE--------------------DNAHNEIL-SNADSLSTFVSEQQMESQELADLT-----------------------------GV P_troglodytes_ENSPTRP00000034378 IGSGCG----GDPKCMDRVCFW-RLGLLRG--PGAE--------------------DNAHNEIL-SNADSLSTFVSEQQMESQEPADLT-----------------------------GV G_gorilla_ENSGGOP00000002136 IGSGCG----GDPKCMDRVCFW-RLGLLRG--PGAE--------------------DNAHNEIL-SNADSLSTFVSEQQMESQEPADLT-----------------------------GV M_mulatta_ENSMMUP00000021894 IGSGCG----GNPKCMHRVFLW-CLGLLRG--PGAE--------------------DNAHNMIL-NHGDSLSTFISEQQMESQEPADLT-----------------------------GV P_troglodytes_ENSPTRP00000034375 ICSGGG----GDPERVDRSS--------QR--PGAE--------------------DNALNEIV-SILQ--PTQVPEQEMEVQEPAEPT-----------------------------GV H_sapiens_ENSP00000276431 ICSGGG----GDPERVDRSS--------QR--PGAE--------------------DNVLNEIV-SILQ--PTQVPEQEMEVQEPAEPT-----------------------------GV P_pygmaeus_ENSPPYP00000020655 ICSGGG----GDPERLDRSS-----HSPQR--PGAE--------------------DNALNEIV-SILQ--PTQVPEQEMEVQEPAEPT-----------------------------GV E_caballus_ENSECAP00000022015 ECPLLG----ADAPR--------PVGSAER--PEAL--------------------DNAYNETL-NNRESSSTLVSEQELEGKEQAEPT-----------------------------GV M_mulatta_ENSMMUP00000021892 ICSGGG----GDPERVHRVFFR-RSRPSRV--PGME--------------------DNARNESL-STRFLQPTQVSEQEIKGQESAEPT-----------------------------GV H_sapiens_ENSP00000310263 ICSGGG----GGPERVHRVLFRRRSCPSRV--PGAE--------------------DNARNETL-SNRYLQPTQVSEQEIQGQELAELT-----------------------------GV G_gorilla_ENSGGOP00000010773 ICSGGG----GDPERVDRSS--------QR--PGAE--------------------DNALNEIV-SILQ--PTQVPEQEMEVQEPAEPT-----------------------------GV P_troglodytes_ENSPTRP00000034377 ICS---------------VLFRRCSSPSRV--PGAE--------------------DNARNETL-SNRYLQPTQVSEQEIQGQELAEPT-----------------------------GV G_gorilla_ENSGGOP00000007840 ICSGGG----GGPERVHRVLFRRRSCPSRV--PGAE--------------------DNARNETL-SNRHLQPTQVSEQEIQGQELAEPT-----------------------------GV P_pygmaeus_ENSPPYP00000020657 ICSGGG----GGPERVHRFLFRRHSCPSQV--PGAE--------------------DNARNETL-SSSYLQPTQVSEQEIRGQELAEPT-----------------------------AV M_musculus_ENSMUSP00000022663 ---GCE----RDPE--------------------SA--------------------NSVHSSLL-DRQTSSTTNDSNHNTE--------------------------------------- G_gorilla_ENSGGOP00000010787 ICSGGG----GGPERVHRVLFRQRSCPSRV--PGAE--------------------DNACNETL-SNRYLQPTQVSEQEIQGQELAEPT-----------------------------GV P_troglodytes_ENSPTRP00000034372 ICSGGG----GGPKRVHR------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000055444 VYPGCE----QDHE------------------------------------------NTVGLSLL-DAQTSRKTNGSHHNTE--------------------------------------- G_gallus_ENSGALP00000000612 ----------GDDGELSWKPSAVVNRLLQR--LGIQ--------------------DNRCNEQIYQNQQQQELLFTAQGSEVPHGVEME------------------------------- O_anatinus_ENSOANP00000021880 ANSVVL------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000013812 SHSSDIKIRIQ-DGNDPSAEERQNSQNAGLEGEEPRPESRPLLQETQHGVTKPSPPLEDEDRGL-GDSLPNTTNSSQTSLSALPTLTSA------------------------------- G_gallus_ENSGALP00000038567 KAERGP----EDEDNMLLQEVKVIRNNASH--PDNE-----------------NSGESPEGQAY-NDVNSEVKNTSPEENSAVSYERGTIPQKNLWCQTRECWKRIKNYSSSPKNRCNST T_nigroviridis_ENSTNIP00000001044 TDQASLFVSGKPDKSGATAEEQQNDQNADL--EEFRPESRPLLQETQPGMTKHSPPLEDEDRGL-GDSLPNTTNSSQTSLSGLP-MTCA------------------------------- M_domestica_ENSMODP00000011508 SRAGQTGYLMGDREKEKPYLWGSS--------------------------------REPLLSYL-VSLLQRGNHPRPPEARGDEPLEMQ-----------------------------NL D_rerio_ENSDARP00000012354 SRSPREMVKICMGDSEEVREEKQNDHNSRI--DDSSQLQPFLEQNYVVGTSVPHPSEAEKDKGL-GDSLPNTANSSQTSLAICAVPSDL-----------------------------QS O_latipes_ENSORLP00000003602 PCKLKPFSVVRREESLSEQRNRQDSHRKSNFCTAVR--------------SFPALCVTIQYKTM-LNSNNEGTSQPRHTLTLK------------------------------------- G_aculeatus_ENSGACP00000007142 LQEQSDSDEDSGNERSSGEAQRLSCLGGMM--PWRL---------------VRASGAEEERKAL-RDSPGSSASNSQHNLTAFPYPYPG------------------------------- O_latipes_ENSORLP00000020293 VHTHSHFEACSSESSTKAKPRKISSNKGRM--NFSD---------------FPSMEVEDPHHKK-KQLFSLPPVVMIHSGTGLSYPSPL--------------------------SLRVR G_aculeatus_ENSGACP00000020911 HCDSSEIVKIPIDESGSTAEERQNHQNAGLEGEECRPESRPLLQET--GMTKASPPLEDEDRGL-GDSLPNTTSSSQTSLSALV-QTVC-----------------------------VS X_tropicalis_ENSXETP00000023053 ------------------------------------------------------------LSFL-SSCVSKITENPGREENPLIPVQLA------------------------------- T_guttata_ENSTGUP00000013762 FYSCVS-----------------------L--PQTP--------------------KEPVSEVE-KKRNKISTLIPESQKETELPLNAA------------------------------- O_anatinus_ENSOANP00000029006 PCRGKG-----------------------------------------------------------------PSLRPETRVSVPVPPAGR------------------------------- R_norvegicus_ENSRNOP00000018492 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000023975 FYSCVS-----------------------L--PQTS--------------------KESVSEAE-VKGSAI-TVLPEIQKEKELLVNAT------------------------------- M_musculus_ENSMUSP00000045240 ------------------------------------------------------------------------------------------------------------------------ 490 500 510 520 530 540 550 560 570 580 590 600 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ H_sapiens_ENSP00000221132 TVQSPGEAQCLLGPAEAEGSQ-RRRLLVPANGAD--PTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTA-GPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHARE P_pygmaeus_ENSPPYP00000020658 TVQSPGEAQCLLGPAEAEGSQ-RRRLLVPANGAD--PTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGIA-GPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAKE P_troglodytes_ENSPTRP00000034378 TVQSPGEAQCLLGPAEAEGSQ-RRRLLVPANGAD--PTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTA-GPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAKE G_gorilla_ENSGGOP00000002136 TVQSPGEAQCLLXPAEAEGSQ-RRXLLVPANGAD--PTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTA-GPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAKE M_mulatta_ENSMMUP00000021894 TVQSPGEAQCLLGPAEPEGSQ-RRRLLVPANGAD--PTETMMLFFDNFADIVPFNSWDQLMRQLGLTNNEIHMVRADTA-GPGDALYAMLMKWVNKTGQDASIHTLLDALERIGERHAKE P_troglodytes_ENSPTRP00000034375 NM-SPGESEHLPEPAEAEGSQ-RRRLLVPANEGD--PTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAA-GHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQ H_sapiens_ENSP00000276431 NMLSPGESEHLLEPAEAERSQ-RRRLLVPANEGD--PTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAA-GHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQ P_pygmaeus_ENSPPYP00000020655 NMLSPGESEHLPEPEEAEGSQ-RRRLLVPANEGD--PTETLRQCFDDFADMVPFDSWEPLMRKLGLMDNEIKVAKAEAA-GHRDTLYTMLIKWVNKTGRDASVHTLLDALEAMGERLAKQ E_caballus_ENSECAP00000022015 SAQSPGEAEHLLGPAGAEGSQMRRRLLVPANGAD--PTESLQLFFDYFPRIVPFKSWKRLMRQLGLTQNEIDVMEAEIT-SHQDALYEMLTIWLKKTGRSASVNTLLDALETLGEKYAKE M_mulatta_ENSMMUP00000021892 TVQSPEEAQRLLEQAEAEGRQ-RKTLPVPVNDAD-----------------------------------------------------------------PTEINTLLDASATLEEGHAKE H_sapiens_ENSP00000310263 TVELPEEPQRLLEQAEAEGCQ-RRRLLVPVNDAD-----------------------------------------------------------------SADISTLLDASATLEEGHAKE G_gorilla_ENSGGOP00000010773 NMLSPGESEHLPEPAXXXXXX-XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXYTMLIKWVNKXGRDASVHTLLDALETLGERLAKQ P_troglodytes_ENSPTRP00000034377 TVESPEEPQRLLEQAEAEGCQ-RRRLLVPVNDAD-----------------------------------------------------------------SADISTLLDASATMEEGHAKE G_gorilla_ENSGGOP00000007840 TVESPEEPQRLLEQAEAEGCQ-RRRLLVPVNDTD-----------------------------------------------------------------PTEISTLLDASATLEEGHAKE P_pygmaeus_ENSPPYP00000020657 TVESPEEPQRLPEQAEAEGCQ-RRRLLVPVNDAD-----------------------------------------------------------------SADISTFLDASATPEEGHAKE M_musculus_ENSMUSP00000022663 -------------PGKTQKT--GKKLLVPVNGND--SADDLKFIFEYCSDIVPFDSWNRLMRQLGLTDNQIQMVKAETL-VTREALYQMLLKWRHQTGRSASINHLLDALEAVEERDAME G_gorilla_ENSGGOP00000010787 TVESPEEPQRLL------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000034372 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000055444 -------------PDRTQSSPLGRKLLVLANGNN--PADALKLIFERCSTEVPFNSWDRLMRHMGLTDNQIQMVRAETQ-VPCEVLYQMLLKWLYQTGLGASINHLLGALEAVGERCALE G_gallus_ENSGALP00000000612 --------GTERRTPDPKVE--TQRKLVPVLGEN--PIALLHRSFNTFVDYVPFPEWKRFGRALDLQENDLYLAEQHDR-VSCEPFYQMLNTWLNQQGSKASVNTLLETLPRIGLSGVAD O_anatinus_ENSOANP00000021880 -----SRLIGTYGWPEFPL---CYFFMVSVNGVHELSEPALEKALPHFEREVPCKSWNGYMIRLGLSQNEIDVARGSER-YTEDQPRSLLRTWQIKMGKGASINTMLETLDEMRLKLIRE T_rubripes_ENSTRUP00000013812 -ITPRQSPSAGRMTPVDVEDP-LRYRLVPVKD----AEKSLKMSFDLFEEHLDVRIHNKFFRAIGVSDNDIRIAQT-------DKVYELLKNWMQKQGLKADINDLLGVLLRMDQRRSAE G_gallus_ENSGALP00000038567 LQPNTQCKVSGVRMPAYCMVQ-KQKYQISIKDL---TQKEARDCFFAFIKEVPVKKWRKLMRT-HLEENDIDKIIYNWPNDIDEQSYQMLLMWKNKMGEKQSIIKLLDELWDIDTRAYSN T_nigroviridis_ENSTNIP00000001044 -TTPRPSPSAVRIAPADVVSK-STHLFMNTC-----PEKSLKMSFDLFDEYLDVQIHNKFFRMIGISDNHIHLAESC---SPPDKVYKLLTTWMQKQGRRADINSLLNALLSMDQRRSAE M_domestica_ENSMODP00000011508 SGKQREEHEELLEEPAEAMT--PQAKLFPANGD---PIGTLQKSFVIFAQKVPWQYWNQYMNLLGLSPNEIAMAKESE--NVIDYPHRMLTMWQQKVGKAATVDILLETLSKIKLKAARE D_rerio_ENSDARP00000012354 CHTNQSSSSVLAWQPPALESE-SSRRLVPLS-----GEESLKKTFDFFEE-IDVHYHNRFFRLIGLSDNAIKSAESL---FPEDRVYELLKIWMEKEGLKADFNSLIDALIYLDQRLSAE O_latipes_ENSORLP00000003602 -KIPRHTSIQKFFLFGAVKSA-ADFLLGPLTR----SEKSLRKSFDLFDEYLDVRIHNKFFRLIGISDNHIRIAENG---AAADKVYELLKNWMQKQGLKADINNLLDALLSLDQRRSAE G_aculeatus_ENSGACP00000007142 --FPAPPAQAGPTAPVQ-----PDRRLVAVN-----GEESLRKCFEYFED-VDVRLHSRFFRHLDVADNVIKSKDHL---AYYDRIHELLTIWVEKAGRGATLNDLLRALLNLKQRRTAE O_latipes_ENSORLP00000020293 FTWSLLSKQEEEQLP----------TLIPVN-----GEQSLRSCFELFEE-LDVDFHKKFFRRLDFSDNAIKSKDNL---LYEDKIHELLNSWVEREGKKANLNELLKVLVELNQKRTAE G_aculeatus_ENSGACP00000020911 PSMPYDDPLQHRLVPVQGEIS-CSGGDLPKG-----SEKSLKKSFDLFDEYLDVRIHNKFFRLIGVSDNHIRIAESG---PPGDKVYELLKNWMQRRGLKADINDLLEALLTMDQRRSAE X_tropicalis_ENSXETP00000023053 ----------------------FAREMDREE-----QETIFRQTWDLFVEHVPMEKWAQFMRSLRLSDNTVWEAKENNRDNAREQNIAMLRAWYQQ--NPGDVNDLLASLHDINLHTPAR T_guttata_ENSTGUP00000013762 -LSSIPPPQSSHELPDCVRP--ARKTQLPDNPA----------VLYAVVDHVPPSRWKEFVRRLGLSDYDLERIELEHR-RLRDAQYEMLRLWKLQTGHAATLEHIGRVLNQMELSGCSD O_anatinus_ENSOANP00000029006 --LTPGQAVDLFGTPLDREPHLGQGLCLTVNNNSS-NNDEQNKIYYLFASKVPPEKWKQFMYYLGLEDNEIHSVMLFHGDSPDDEHFEMLRKWNYKLGKEATVFKALETL---------- R_norvegicus_ENSRNOP00000018492 --------------------------------------------------------------------------------------------------RQRHTSIVASELEAFQQEQQED G_gallus_ENSGALP00000023975 -PPSVPLLQSSHELPDCVRA--ARKRQLPDNPA----------ILYTVVDHVPPSRWKEFVRRLGLTENDLERIEMEHR-HLRDAQYEMVSLWKLQMGHAATVEHISCVLNQMELSGCSE M_musculus_ENSMUSP00000045240 --------------------------------------------------------------------------------------------------RHLHTSSVAKELEPF-QEQQEN 610 620 630 =========+=========+=========+= H_sapiens_ENSP00000221132 KIQDLLVDSGKFIYLEDGTGSAVSLE----- P_pygmaeus_ENSPPYP00000020658 KIEDLLVDSGKFIYLEDGTGSAVSLE----- P_troglodytes_ENSPTRP00000034378 KIQDLLVDSGKFIYLEDGTGSAVSLE----- G_gorilla_ENSGGOP00000002136 KIQDLLVDSGKFIYLEDGTGSAVSLE----- M_mulatta_ENSMMUP00000021894 RIQDLLVDSGKFIYVEDGTGSAVSLE----- P_troglodytes_ENSPTRP00000034375 KIEDHLLSSGKFMYLEGNADSAMS------- H_sapiens_ENSP00000276431 KIEDHLLSSGKFMYLEGNADSAMS------- P_pygmaeus_ENSPPYP00000020655 KIEDHLLSSGKFMYLEGNADSAMS------- E_caballus_ENSECAP00000022015 TIQDHLLASGKYVYEEGGAGSAVS------- M_mulatta_ENSMMUP00000021892 TIQDHMVDSEKLFY-EDDAGFATSSL----- H_sapiens_ENSP00000310263 TIQDQLVGSEKLFYEEDEAGSATSCL----- G_gorilla_ENSGGOP00000010773 KIEDHLLSSGKFMYLEGNADSAMS------- P_troglodytes_ENSPTRP00000034377 TIQDQLVGSEKLFYEEDEAGSATSCL----- G_gorilla_ENSGGOP00000007840 TIQDQLVGS---------------------- P_pygmaeus_ENSPPYP00000020657 TIQDQLVGSEKLFYEEDDAGSATSCL----- M_musculus_ENSMUSP00000022663 KIEDYAVKSGRFTYQNAAAQPETGPGGSQCV G_gorilla_ENSGGOP00000010787 ------------------------------- P_troglodytes_ENSPTRP00000034372 ------------------------------- R_norvegicus_ENSRNOP00000055444 EIEDYAVKSGKFVYQNTTA------------ G_gallus_ENSGALP00000000612 IIASELISKGYFQYEVS-------------- O_anatinus_ENSOANP00000021880 SIQESLIDSKLYVFAS--------------- T_rubripes_ENSTRUP00000013812 SIASDALRKGYYKHAETP------------- G_gallus_ENSGALP00000038567 IVHT-LTSNNIISKKEATA------------ T_nigroviridis_ENSTNIP00000001044 SVASAALLKGYYKHAET-------------- M_domestica_ENSMODP00000011508 SIQEELIHEKLYVYKESEPEKSLT------- D_rerio_ENSDARP00000012354 NIIAKAINNSCFKYEEE-------------- O_latipes_ENSORLP00000003602 CIAYEALRKGYYRHADV-------------- G_aculeatus_ENSGACP00000007142 IIKEKAIRNGHYVEAQG-------------- O_latipes_ENSORLP00000020293 KIMKKVLDNGQYCTESK-------------- G_aculeatus_ENSGACP00000020911 SIASEALRRGYYKHA---------------- X_tropicalis_ENSXETP00000023053 TIASILVQKGDYVEIN--------------- T_guttata_ENSTGUP00000013762 AVQESLLNQNSPQPCSLHNHL---------- O_anatinus_ENSOANP00000029006 ------------------------------- R_norvegicus_ENSRNOP00000018492 AIRFPVIEVGPSVTEEEAAFNCMNSG----- G_gallus_ENSGALP00000023975 AIQEALLNQNSHQPCSFHSHR---------- M_musculus_ENSMUSP00000045240 TIRFPVTEVGFAETEEETASN----------