>H_sapiens_ENSP00000212369 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRNS------------QLNSARL EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLSNNNQTSVTP----VPSVLPNAI--GSSAMAS------ ----------------------------------------------------TS----GL VIT----------SPSNLSDLK-ECSGSRKARV---LY----DYDAANSTELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >P_pygmaeus_ENSPPYP00000001373 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRNS------------QLNSARL EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLSNNNQTSVTP----VPSVLPNAI--GSSAMAS------ ----------------------------------------------------TS----GL VIT----------SPSNLSDLK-ECSGSRKARV---LY----DYDAANSTELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >M_mulatta_ENSMMUP00000017727 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRNS------------QLNSARL EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLSNNNQTSVAP----VPSVLPNAI--GSSAMAS------ ----------------------------------------------------TS----GL VIT----------SPSNLSDLK-ECSGSRKARV---LY----DYDAANSTELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >P_troglodytes_ENSPTRP00000001595 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRNS------------QLNSARL EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLSNNNQTSVTP----VPSVLPNAI--GSSAMAS------ ----------------------------------------------------TS----GL VIT----------SPSNLSDLK-ECSGTRKARV---LY----DYD-ANSTELSL-LAD-- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >M_musculus_ENSMUSP00000101816 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETKSS------------QLNSARP EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLSNNNQTSGTP----VPYALSNAI--GPSAQAS------ ----------------------------------------------------TG----SL VIT----------CPSNLNDLK-ESSNNRKARV---LY----DYDAANSTELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >R_norvegicus_ENSRNOP00000042225 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKVWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETKSS------------QLNSARP EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YVSNNNQTSGTP----VPYTLSNTI--GPSAVAS------ ----------------------------------------------------TG----SL VIT----------CPPNLSDLK-DSSSTRKARV---LY----DYDAANSTELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >E_caballus_ENSECAP00000007417 ------------------------------------------------------------ ---QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----SKERKLLQNKRLDLDAAKTRL-KK---AKAAETRAS------------------- ------------------S--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YHCNNNQTSVAP----MPSASSNVI--GSSALTS------ ----------------------------------------------------TS----GL VIA----------SPSNLVDLK-ECSGSRKARV---LY----DYDAANSSELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGRV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >T_guttata_ENSTGUP00000006527 ---------------------------------MDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKLWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RMNNPELLGQYMIDAGNEFGPG-TAY-G---NALIKCGE TQKRIGAADRELIQTSAINFLTPLRNFIEGDYKTI------------------------- -----TKERKLLQNKRLDLDAAKTRL-KK---AKVAEARAA----VKVFFNDTLLKAFPN RQSFA---CMSRAAVSRGS--EQEVRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --T-----------------FLSNNNQSSTTP----VQSVSSPSVLASASASLP------ ---------------------------------------------------SVS----NS MVT------------SGLSELK-SSSGSRKARV---LY----DYDAANSSELSL-LADE- --VITVYSIPGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >A_carolinensis_ENSACAP00000001683 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKLWTEKVMKQTEVLLQPNP-NARME EFVYEKLDR-----KA-PS--RVNNPELLGQHMIDAGNEFGPG-TAY-G---NALIKCGE TQKRIGAADRELIQTAAINFLTPLRNFIEGDYKTI------------------------- -----TRERKLLQNKRLDLDAAKTRL-RK---AKVAEARAA------------------- ------------------S--EQEVRIAQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --T-----------------FLANNNQSTTTC----VPSSSNTTT-AASSVSVT------ ---------------------------------------------------ASL----NV AAP------------SSFGELK-SSSGSRKARV---LY----DYDAANSTELSL-LADE- --VITVYSIPGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >G_gallus_ENSGALP00000010137 ---------------------------PPKMNIMDF--------NMKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKQWTEKIMKQTEVLLQPNP-NARIE EFFYEKLDR-----KA-PS--RMNNPELLGQYMIDAGNEFGPG-TAY-G---NALIKCGE TQKQIGTADRELIQTSAINFLTPLRNFIEGDYKTI------------------------- -----TKERKLLQNKRLDLDAAKTRL-KK---AKVAEARAA------------------- ------------------S--EQEVRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYKYMLDLQKQLG-------S------------------------FPS-- --T-----------------FLSNNNQSSSAP----VQSVSTPSVLASASASLP------ ---------------------------------------------------SVS----NS VVT------------SGISELK-SSSGSRKARV---LY----DYDAANSSELSL-LADE- --VITVYSIPGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >C_familiaris_ENSCAFP00000030020 ------------------------------------------------------------ ---QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETKAS------------------- ------------------S--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --S-----------------Y-CNNNQTSVAP----VPSASSNVI--GSSTLTS------ ----------------------------------------------------TS----GL VIA----------SPTNLNDLK-ECSGSRKARV---LY----DYDAANSSELSL-LADE- --VITVFSVVGMD-SDWLMGER---GNQKGRV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >B_taurus_ENSBTAP00000041643 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRAS------------------- ------------------S--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YHSNNNQTAVAP----VPSASSNVI--GSSALTS------ ----------------------------------------------------TS----SL VIT----------SPSNLTDLK-ECGGSRRARV---LY----DYDAANSTELSL-LADE- --VITVFRA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GFSLFLI------------------------------------ --------------------------------------------------------- >O_anatinus_ENSOANP00000013434 SRWPSGVPGGGGAEGLGGARRGSERRVGGGVKMMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKQWTEKIMRQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RTNNPELLGQYMIDAGNDFGPG-TAY-G---NALIKCGE TQRRIGTADRELIQTSAINFLNPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAEARAS------------------- ------------------S--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPT-- --T-----------------FLANNNQSSTIT----VPHVSASPSVASTSASLP------ ---------------------------------------------------SSS----SS ITA------------PGFSDLK-EASGSRKARV---LY----DYDAANSSELSL-LADE- --VITVYSISGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >M_domestica_ENSMODP00000010099 ----------------------------PNMSIMDF--------NVKKLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLSK--AECTKQWTEKMMRQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PT--RINNQELLGQYMIDAGNDFGPG-TAY-G---NALIKCGE TQKRIGTADRELVQTAAINFLTPLRNFIEGDYKTI------------------------- -----TKERKLLQNKRLDLDAAKTRL-KK---AKIAETRAL------------------- ------------------S--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --V-----------------FVSNNSQSSTTS----MSNISTSSSGITTSL-LP------ ---------------------------------------------------STS----GT AIT------------PAIGDLK-ESSGNRKARV---LY----DYDAANSTELSL-LADE- --VITVYSIVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >X_tropicalis_ENSXETP00000001033 ---------------------------------MDF--------NVKKLAADAGTFLSRA V--QFTEEKFGQAEKTE-LDAHLENLLSK--AECTKVWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RLNTEEQLAQYMTDAGNEFGPG-TAY-G---NALIKCGE TQKRIGVAHRELVQTAAINFLTPLRNFIEGDFKTM------------------------- -----SKEKKLLQNKRLDLDAAKTRL-KK---ARVTEARAA------------------- ------------------A--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYFAQSYQYMLDLQKQLG-------S------------------------FPS-- --T-----------------FVSNNNQSTLTP----MQSVSVPSV--SASAQAP------ ---------------------------------------------------SAK----SS LVT------------SGFTELK-ASNGSRKARV---LY----DYDAANSSELSL-LADE- --VITVYSMPGMD-SDWLMGER---GHQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000090965 ---------------------------------MDF--------NVKRFAADAGTLFSRA VQKQFTEEKFGQAEKTE-LDAHLETLLTR--AECTKHWTEKILKQTEVLLQPNP-NARIE ELLYEKLDK-----KA-PP--RMNNHELMGQSMIDSGNEFGPG-TAY-G---NALIKCGE TEKQIGGAEREFIQTSAINFLTPFRNFLEGDFKTI------------------------- -----LKERKLLQNKRLDLDAAKTKL-KK---AKMADARAV------------VRDGLRL EGHSL---QMWAEEVT-TA--EQDLKMTQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMVDLQKQLG-------N------------------------FPS-- --A-----------------FTSNNNQSTASG----GAGVSVPIL--PLSTPLP------ ---------------------------------------------------ST-----TS NTS------------SGFTEMQ-NFSGSRKARV---LY----DYDAAGSNELSL-LADE- --VIMVSSVPGMD-SDWLMGER---GSQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >O_cuniculus_ENSOCUP00000003076 ------------------------------------------------------------ ----FTEEKLGQAEKTE-LDAHLENLLSK--AECTKIWTEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-G---NALIKCGE TQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTI------------------------- -----AKERKLLQNKRLDLDAAKTRL-KK---AKAAETRNS------------QLNSARL EGDNI---MXXXXXXX-XX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG-------S------------------------FPS-- --N-----------------YLCNNNQTSGTP----VPSVLSNVI--GSSAMAS------ ---------------------------------------------------ATS----GL VIN----------SPSNLNDLK-ESSGSRKARV---LY----DYDAANSTELSL-LADE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >G_aculeatus_ENSGACP00000002710 ---------------------------------MDF--------NVKRLAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLVR--AENTKQWTERIMKQTEVLLQPNP-NVRLE EFVYEKLEK-----KA-PT--RLNNHDLLGQSMIESGNEFGPG-TAY-G---NALIKCGE TEKQIGGAERELIQSAAINFLTPFRNFLEGDFKTI------------------------- -----LKERKLLQVKRLDLDAAKTKL-KK---ARMADARAA------------------- ------------------A--EQELRMSQSEFDRQAEITRLLLEGVSSTHAHHLRCLNDF VEAQTTYYAQCYQYMVDLQKQLGS------S------------------------FPS-- --T-----------------F-SNNNQSSVSG----GASISVPTI--SVSASLP------ ---------------------------------------------------SVSAGHGSS AAS------------GGFNELR-GSNGSRRARV---LY----DYDAASSSELSL-LADE- --VIVVSSVPGMD-SDWLMGER---GTQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000096524 ---------------------------------MDF--------NVKRFAADAGTLFSRA VQKQFTEEKFGQAEKTE-LDAHLETLLTR--AECTKHWTEKILKQTEVLLQPNP-NARIE ELLYEKLDK-----KA-PP--RMNNHELMGQSMIDSGNEFGPG-TAY-G---NALIKCGE TEKQIGGAEREFIQTSAINFLTPFRNFLEGDFKTI------------------------- -----LKERKLLQNKRLDLDAAKTKL-KK---AKMADARAV------------------- ------------------A--EQDLKMTQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMVDLQKQLG-------N------------------------FPS-- --A-----------------FTSNNNQSTASG----GAGVSVPIL--PLSTPLP------ ---------------------------------------------------ST-----TS NTS------------SGFTEMQ-NFSGSRKARV---LY----DYDAAGSNELSL-LADE- --VIMVSSVPGMD-SDWLMGER---GSQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000045932 ---------------------------------MEF--------NVRRLAADAGTFLSRA V--QFTEEKFGQAEKTE-LDAHLEMLLSR--AESTKHWTEKIMKQTEVVLQPNP-NVRVE EFLYEILDK-----KV-PT--RANNHEMLGQCMIDSGHEFGPG-TAY-G---SALIKCGE TEKLLGSAEKEFIHSSAINFLTPFRNFIEGDFKTI------------------------- -----LKERKLLQNKRLDLDAAKNRM-KK---ARVADARSA------------------- ------------------A--ETELRIAQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VDAQAAYYAQCYQYTVNLQKQLG-------S------------------------FPS-- --T-----------------F-SNNNQPSGSS----SASVCVPTA--PPAASLP------ ---------------------------------------------------APP----PS QAS------------PALNELR-SSSGTRKARV---LY----DYDAASSTELSL-LADE- --VITVSSVPGMD-SDWLMGQR---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >T_rubripes_ENSTRUP00000017379 --------------------------------TMDF--------NVKRLAADAGTFLSRA V--QFTEEKFGQAEKTE-LDAHLENLLVR--AENTKLWTERIMKQTEVLLQPNP-NVRLE EFVYEKLEK-----KA-PT--RMNNHELLGQTMIDSGSEFGPG-TAY-G---NALMKCGE TEKQIGGAEREFIHGAAINFLTPFRNFLEGDFKTI------------------------- -----LKERKLLQVKRLDLDAAKTRL-KK---ARMADARAA------------------- ------------------A--EQELRMTQSEFDRQAEITRLLLEGISSTHAHHLRCLNDL VEAQTTYYAQCYQYMVDLQKQLG-------S------------------------FPS-- --S-----------------F-TNNNQSAASG----GASASAPTI--PVSASLP------ ---------------------------------------------------SAG---GGS TAS------------GGFNELR-SSSASRRARV---LY----DYDAASSSELSL-LADE- --VITVSSVPGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000022156 ------------------------------LFNMDF--------NVKRLAADAGTFLSRA V--QFTEEKFGQAERTE-LDAHLENLLVR--AESTKVWTERIMKQTEVLLQPNPTDVRLE EFVYEKLEK-----KA-PT--RMNNHELLGQALMDSGSECGPG-TAY-G---NALMKCGE AEKLIGGAEREFMQGAAINFLTPLRNFLEGDFKTI------------------------- -----LKERKLLQVRRLDLDAAKTRL-KK---ARLAEARAA------------------- ------------------A--EQELRVTQSEFDRQAEITRLLLEGISSTHAHHLRCLNDL VEAQSSYYAQCYQYMVDLQKQLG-------S------------------------FPS-- --S-----------------F-TNNNQASVSG----GAGASAPTI--AVSSSL------- ------------------------------------------------------------ ------------------SELR-GSGASRRARV---LY----DYDAASSSELSL-LADE- --VITVSSVPGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >G_gallus_ENSGALP00000007175 ---------------------------------MDF--------NVKKLASDAGVFFSRA M--QFTEEKLGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMTEAANDFGPG-TPY-G---KTLIKVGE TQRRLGAAERDFIHSASINFLTPLRNFLEGDWRTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAA----AVPDFQETRPRNYVL SASAS---ALWSDEVE-KA--EHELRLTQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VESQTNYYAQCYQYMLDLQKQLG-------R------------------------FSG-- --T-----------------FVGNAESTSPPP-----AAASPPAVAATTLPAVP------ ---------------------------------------------------TIP----VV PTIVGVPNTVAE-SVLNPNEVKPPASGTRKARV---LY----DYEAADSTELAL-LADE- --MITVYSLPGMD-PDWLIGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >G_aculeatus_ENSGACP00000004756 ---------------------------------MDF--------NVKKFASGAGLFFTRA V--QFTEEKLGQAEKTE-LDAHFENLLSR--ADCTKLWTEKIYRQTEALLQPNP-SARIE EFLYEKLDR-----KA-PS--RVTNGELLGQYMTDAAKEFGPG-TPY-G---GTLIEVGE CERRLGAAEREFLQTSAISFLTPLRNFLEGDWRTI------------------------- -----SKERRLLENLRLDLDACKTRL-KK---AKVAEAKAA----MAPDFQETRPRNYVL SASAS---ALWSEEVE-KA--EHELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VEAQAAYYKQCHFHMQELQKELG-------R------------------------LPD-- --A-----------------FALNSTNSAASA---------------CSASEGP------ ------------------------------------------------------------ ---------VET-DTLKIEEVQAPATGSRKAKV---LY----DYDAADSSELSL-LADE- --LITVYTVPGMD-CDWLMGER---GNQRGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >O_latipes_ENSORLP00000007330 --------------------------------AMDF--------NVKRFAADAGTFLSRA V--QFTEEKLGQAEKTE-LDAHLENLLVR--AENTKQWTEKIMKQTEVLLQPNP-NVRLE EFVYEKLEK-----KA-PT--RMNNHELLGQSMIESGSEFGPG-TAY-G---NALIKCGE TQKQIGGAEREFIQSAAINFLTPFRNFLEGDFKTI------------------------- -----LKERKLLQVKRLDLDAAKTRL-KK---ARMSDARAA------------------- ------------------A--EQELRMTQSEFDRQAEITRLLLEGVSSTHAHHLRCLNDL VEAQTTYYAQCYQYMVDLQKQLG-------S------------------------FPS-- --T-----------------F-SNNNQ--VSG----GASISVPTI--PVSASLP------ ---------------------------------------------------SVS----AG QSS--------------LSASA-GFSGSRKARV---LY----DYDAASSSELSL-LADE- --VSTRSQYAKRT-SRTFLGSK-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PGTTSE--------------------------------------- --------------------------------------------------------- >C_familiaris_ENSCAFP00000029646 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMAEAASELGPT-TPY-G---KTLIKVAE AEKRLGAAERDFIHTASINFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKAT----TVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VESQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPVS-PP-----LSSTSPTTAVATMPVGP------ ---------------------------------------------------SVA----GL APP-------GE-AALRL-EVTPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >M_mulatta_ENSMMUP00000015442 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMADAASELGPT-TPY-G---KTLIKVAE AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATVDSGTVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----SL APP-------GE-ASLCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >H_sapiens_ENSP00000361634 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMADAASELGPT-TPY-G---KTLIKVAE AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATAEGPTVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----SL APP-------GE-ASLCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >P_troglodytes_ENSPTRP00000048816 ---------------------------------MNF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMADAASELGPT-TPY-G---KTLIKVAE AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATCEGDTVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----SL APP-------GE-ASLCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >M_musculus_ENSMUSP00000109251 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTERILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMAEAASELGPS-TPY-G---KTLIKVSE AEKRLGAAERDFIHTASLSFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATCEGDTVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTTAATMPVVP------ ---------------------------------------------------TGA----VL APP-------EE-AALCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >B_taurus_ENSBTAP00000014065 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFESLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMAEAASELGPT-TPY-G---KTLIKVAE AEKHLGAAERDFIHTASINFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDASKARL-KK---AKAAEAKAT----TVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF IESQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTAEPAS-PP-----LSSTSPTTTAATMPMGP------ ---------------------------------------------------SVA----DL APP-------GE-AALRLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000051402 ---------------------------------MDF--------NVKKLASDAGVFFTRA V--QYTEEKLGQAEKTE-LDAHLENLIAR--ADCTKNWTEKIFRQTEVLLQPNP-SARIE EFFYEKLDK-----KI-PS--RITNAELLGQYMQDAAKDFGPG-SPY-G---STLITVGE YQKRLGGSEREFLQTSAINFLTPLRNFLEGDWKTI------------------------- -----SRERRLLENRRLDLDVCKARL-KK---AKLAEAKAA----AAPDFQETRPRNYVL SASAS---ALWSEEVD-KA--EHELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VEAQAAYYAQCHRHMQDLQKELS-------SANGDT-------------------FPN-- --A-----------------FAVNASTSGVSA-----------GPSPLSTGTQP------ ---------------------------------------------------GPS----SP SRPPNPPNALES-NTLKIEEVKPPATGTRKAKV---LY----DYDAADTSELSL-LADE- --LITVYTVPGMD-PDWLIGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >R_norvegicus_ENSRNOP00000057413 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTERILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMAEAASELGPN-TPY-G---KTLMKVSE AEKRLGAAERDFIHTASLSFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKAT----TVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRAAQTEFDRQAEVTRLLLEGISSAHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTTAATMPVVP------ ---------------------------------------------------TGA----GL APP-------EE-AALCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >G_aculeatus_ENSGACP00000024428 ---------------------------------MDF--------NVKKLACGAGVFFTRA V--QFTEEKLGQAEKTE-LDPHLENLITR--ADSTKNWTEKILRQTEVLLQPNP-SARIE EFIYDKLDK-----KL-PS--RTTNTELLGQYMLEAANEFGPG-TPY-G---STLITVGE YQKRLGGAERDLLQASAVGFLTPLRNFLEGDWRTI------------------------- -----SKERRLLENRRLDLDICKARL-KK---AKLAEAKAA----AAPDFQETRPRNYVL SASAS---ALLSEEAD-KA--EHELRVAQAEFDRQAEVTKLLLEGIGSTHLNHLRCLQDF AEAQATYYAQCHHHMQDLQRELS-------S------------------------TPH-- --S-----------------APVVCPDPVSSA--------------FLSGPPSP------ ---------------------------------------------------GAS----VS SLS-------SQ-RPLAMEQTQLPVTGTRKAKV---LY----DYEGHDGTELSL-LADE- --LITVHTVPGMD-PDWLIGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >X_tropicalis_ENSXETP00000028209 ---------------------------------MDF--------SVKKLASDAGVFFSRA V--QFTQENLGQAEKTE-LDAHFENLLTR--ADNTKNWTEKILRQTEVLLQPSP-SARVE EFLYEKLDR-----KI-PS--RVTTAELLGQYMTEAANDFGPS-TPY-G---QTLIKVGE TQKHLGTAERDFIHSSSINFLTPLRNFLEGDWKTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAAVPD-ALPDFQETRPRNYIL SASAS---AMYCERLNYSA--EHELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF AEAQATYFAQSYQYMVDLQKQLG-------SSRAEL-------------------FPA-- --P-----------------VVGNTDPAS-PP-----LSTSPP---PATLPVLQ------ ---------------------------------------------------VAS----SN P---------GE-VPLNPVEVPPPVSGTRKARV---LY----DYEAADSKELSL-SADE- --LITVYSLPGLD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >T_guttata_ENSTGUP00000004458 ------------------------------------------------------------ L--QFTEEKLGQAEKTE-LDAHFENLLAR--ADCTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMTEAANDFGPG-TPY-G---KTLIKVGE TQRRLGAAEREFIRSASISFLTPLRNFLEGDWRTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAAKKALAVPDFQETRPRNYVL SASAS---ALWSDEVE-KA--EHELRLTQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VESQTNYYAQCYQFMLDLQKQLG-------SSKGEI-------------------FSG-- --T-----------------FVGNAESAS-PA-----AATSSPAVAAATLPAVP------ ---------------------------------------------------TIP----VV PTIVG--------GVLNPNEVKPPASGTRRARV---LY----DYEAADSTELAL-LADE- --MITVYSLPGMD-PDWLIGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >O_latipes_ENSORLP00000017966 ---------------------------------MDF--------NVKKLASDAGVFFTRA V--QFTEEKLGQAEKTE-LDPHLENLITR--ADSTKNWTEKILRQTEVLLQPNP-SARIE EFIYDKLDK-----KL-PS--RMTTAELLGQYMLDAAKEFGAD-SPY-G---STLITVGE YQKRLGGAEREFLQTSAAAFLSPLRNFLEGDWRTI------------------------- -----SKEKRLLENRRLDLDICKARL-KK---AKHAEAKAA----AAPDFQETRPRNYVL SASAS---ALLSEEVD-KA--EHELRVAQTEFDRQAEVTRLLLEGISSTHLNHLRCLQDF AEAQTTYFSQCHHHMQELQRELH-------RASLCFL----------------------- --------------------LNVRCANAVGAP----HSSAASSNPAFPSDHSSP------ ---------------------------------------------------GAS----FS ACD----------PKPGPLSMEPPATGTRKAKV---LY----DYDAHDASELSL-LADE- --LITVYTVPGMD-PDWLVGER---GNEKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >T_rubripes_ENSTRUP00000034215 ---------------------------------MDF--------NVKKLASDAGVFFTRA V--QFTEEKLGQAEKTE-LDPHLENLISR--ADATKNWTEKMLRQTEALLQPNP-STRIE EFIYDKLDK-----KL-PS--KVTNAELLGQYMLDAANDLGPG-TPY-G---STLITVGE YQKRLGGAEREFLHIATANFLSPLRNFLEGDWRTI------------------------- -----SKERRLLENRRLDLDICKARL-KK---AKQAEAKAA----AAPDFQETRPRNYVL SASAS---ALLSEEVD-KA--EHELRVAQTEFDRQAEVTRLLLEGISSTHLNHLRCLHDF AEAQATYYAQCHHYMQDLQRELS-------RSGSST-------------------GGH-- --MDLDSSDVEGNNGDSFMSVTHRGNNAAGAP---------------PAAAGGP------ ---------------------------------------------------NLS----SS ASS-------SH-GTLTVEQL--PVTGTRKAKV---LY----DYDAHDASELSL-LADE- --LITVYTLPGMD-PDWLIGER---GNNKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >P_pygmaeus_ENSPPYP00000022048 ------------------------------------------------------------ ----FTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMADAASELGPT-TPY-G---KTLIKVAE AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKAT----TVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------R------------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----SL APP-------GE-ASLCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >E_caballus_ENSECAP00000004069 ------------------------------------------------------------ ---QFTEEKFGQAEKTE-LDANFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMAEAASELGPT-TPY-G---KTLVKVAE AEKRLGAAERDFIHTASINFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATCEGDTVPDFQETRPRNYIL SASAS---ALWNDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VESQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPTS-PP-----LSSTSPTTTAATMPVGP------ ---------------------------------------------------SVA----GL GPP-------GE-AALCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >O_latipes_ENSORLP00000021066 ---------------------------------MDF--------NVKRLATEAGLFLTRA V--QFTEEKLWQSEKTN-LDQDFENLTVR--ADCTKHWTEKILRQTEILLQPNP-SARIE EFLYEKLDM-----KA-PS--RVTNSELLGQHMEDAAKELGLE-SPY-G---STLVKVGE CERRLGAVEKDFIQTADISFLSPLRNFLEGDCRII------------------------- -----SKERRLLENLRLDLDACKTRV-KK---AKAAEAKVASEAEVVPDFQETRPRNYVL SASAS---ALWTEEVE-KA--EQGLKTAQKEFDRQAEVTRLLLEGISCTHVNHLRCLHEF VEAQAAYYRQCHLHMQDLQEELR-------SQRFEVLSSR---------------LPG-- --G-----------------FAQNSSQNAPPP-------------------SLP------ ---------------------------------------------------EPE----SV SSPV---------ETLTIEEVQAPASGTRKAKV---LY----DYDAADCSELSL-LADE- --IITVYTMPGME-SDWLVGER---GNQRGRV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000004657 ---------------------------------MDF--------NMKKLASDAGLFFTRA V--QFTEEKLGQAEKTE-LDPHLENLLAR--ADATKNWTEKVLRQTEALLQPNP-SARIE EFIYDKLDR-----KL-PS--KVTNAELLGQHMLDAAADLGPE-TPY-G---STLTTVGE YQKRLGGAEREFLYIATANFLTPLRNFLEGDWRTI------------------------- -----SKERRLLENRRLDLDICKARV-KK---AKQAEAKAA----AAPDFQETRPRNYVL SASAS---ALLSEEVD-KVRRSRELRVAQTEFDRQAEVTRLLLEGISSTHLNHLRCLHDF AEAQASYYAQCHHYTQELQRELS-------RRRRRK-------------------ASA-- --APAADS--------SPCLFPHRCANPAAAA---------------------P------ ---------------------------------------------------KPS----AA ASS-------SH-SALGVEQTPLAVTGTRKAKV---LY----DYDAHDASELSL-LADE- --LITVYTVPGMD-PDWLVGER---GNDKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >M_domestica_ENSMODP00000029534 ---------------------------------MDF--------NMKKLASDAGIFFTRA V--QFTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMTEAANELGPE-TPY-G---KTLIKVGE TEKCLGAAERDFIHSASINFLTPLRNFLEGDWRTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAA----AVPDFQETRPRNYIL SASAS---ALWSDEVD-KA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVSVPDPLED- --SDTELFSSFLPHLKKN------------SSFPSR-------------------FPG-- --T-----------------FVGNTEPAS-SP-----LSSASLATAAATIPVVP------ ---------------------------------------------------TVA----GI PAT-------GE-AAISLDDVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNRKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >C_intestinalis_ENSCINP00000010846 ---------------------------------MEFRVPKLTLPDMRQFTSDATTMFTRA K--QFTEEKLGNAEKTE-YDANFENLQMR--YDKTKHWTEKLKSQTEASLQPNP-NTRME DFVYLKLDR-----KP-PD--RVNNTEQLGLTMIEAGNDFGPG-TAY-G---GALVKCGE AQMKLGQAQQTFIQTTLQNFLQPLSNFLEGDCKTI------------------------- -----QKERKTLEKKRLDLDASKAKV-RR---AKTLEARQV----VSCVFFLLRLTSLIL GVDWK----LKHTFVP-QS--ESELRITQTDFDRQQEITRLLLEGVSSTQAHHSRSLNEF VDAQTEYYAKCYQCMKDLQAQLS-------L------------------------FTK-- --M----------------AYKEFKNICDKTC----EPSPSLGLYNRSNSTKSTVQ---- -------------------------------------------------V--------GN ITG------------AHNNEYT-PLSASKQARV---LY----DYDATDSTELSL-LADE- --IIYVHTAPGLS-KDWMMGQR---GTTKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PASYISLLD------------------------------------ --------------------------------------------------------- >G_gorilla_ENSGGOP00000013679 ------------------------------MNIMDF--------NVKKLAADAGTFLSRA V--QXXXXXXXXXXXXX-XXXXXXXXXXX--XXXXXXXXEKIMKQTEVLLQPNP-NARIE EFVYEKLDR-----KA-PS--RINNPELLGQYMIDAGTEFGPG-TAY-X---XXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------------------------- -----XXXXXXXXXXXXXXXXXXXXX-XX---XXXXXXXXX------------QLNSARL EGDNI---MIWAEEVT-KS--EQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDF VEAQMTYYAQCYQYMLDLQKQLG--------------------------------XXX-- --X-----------------XXXXXXXXXXXX----XXXXXXXXX--XXXXXXX------ ----------------------------------------------------XX----XX XXX----------XXXXXXXXX-XXXXXXXXXX---XX----XXXXXXXXXXXX-XXXX- --XITVFSVVGMD-SDWLMGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYLELLN------------------------------------ --------------------------------------------------------- >A_aegypti_AAEL009754-PA ----------------------------MNIKMPDF--------DVKKFVKDAGSTLSRV V--QLTEEKLGTSEKTE-MDRHFEHLSER--SDCARTWTEKIVRDTEAALIPNP-ANRVE DFIFEKIEK-----QK-PK--RLSNLEYLGLDMIEGGGEFGQD-GAY-G---SALIKVGQ AEQKLGSCERDFIGSAGMCFIQPLKKFLEGEMKTI------------------------- -----TKEKGILESKRLDLDACKNRV-RK---ARSMLGQQT------------------- ------------------A--ERDLRVAQSEFDRQAEITKLLLEGISTTQATHLRHLHAF VESQVRYYGQCNKIMSDLQRELA-------S----------------------LGGPQ-- --P-----------------YVPVAGYEDDEA---NGLSGRVNNIELG------------ ------------------------------------------------------------ -----------------------VNPGYKRARV---LC----SYDAKDGTELNL-TANE- --VIFVCECNPSN-SDYMNGKQ---GLLKGLV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PKAFLELLDD----------------------------------- --------------------------------------------------------- >A_gambiae_AGAP010376-PA ----------------------------MNIKMPDF--------DVKKFVKGAGSTLSRV V--QLTEEKLGTSEKTE-MDARFEHLSER--SDSAKLWTEKIMRDTEAALIPNP-ANRVE DFIFEKIEK-----QK-PK--RLSNLEYLGLDMIEGGGEFGQD-GPY-G---SALIKVGQ AEQKLGSCERDFIGSAGMCFIQPLKKFLEGEMKTI------------------------- -----TKEKGVLESKRLDLDACKNRV-RK---ARSMIGQQAKDG-ISPEV---------- -------------TLE-QA--ERDLRVAQSEFDRQAEITKLLLEGISTTQATHLRYLHSL VEAQVRYYGQCNKIMSDLQRELL-------TTLPTDHNITSRNPDDIRAASSYLGGPQ-- --P-----------------YVPVSGYEDEDA-----LSERVNNIELG------------ ------------------------------------------------------------ -----------------------ANSGYRRARV---LC----SYDAKDGTELNL-SSNEA RAVIFVCECNPPH-SDYMNGKQ---GLLKGLV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PKAFLEMLDDD---------------------------------- --------------------------------------------------------- >C_elegans_F35A5.8a ---------------------------------MDF--------NFKKIASDAGGFFSRA K--QLTEETFLKAERTE-LDSHFENLLQR--ADKTEDHTRRLLSAIEGYLQPNP-TVRME EVFYEKLEL-----KK-DGAIRQNNLEQLSTAMTEAGEQFGET-TPY-G---SALLKVAQ TENRLGQAERELCGQAATNTLLPIRRFLEGDMKTI------------------------- -----QKERKVLNSKRLDLDACKSRL-KK---AKTVDLQTVTNSKTSGGF---------- -------------TIE-QA--EADVRVAQAEFDKQSEITKLLLEGIQTAHNNQLKCLRDF VEAQMSFYAQSHQLMADLQRELS-------GTMSFR-------------------GSS-- --A-----------------ILVNNSGDPPNG---------------------------- --------------------------------------------------RTMA----AA IAA------------AKPSGLLPDDLGTKQAKV---IM----DYDAVLPQEISV-TQND- --ILIVYRLPGMD-AEYVMAEK---GGKRGKL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVSYIELL------------------------------------- --------------------------------------------------------- >D_melanogaster_FBpp0085742 ----------------------------MNINLPNF--------NVKNLVKEAGSTISRV V--QLTEEKLGTTERTE-YDLHFQNLAER--ADVTKTWTEKIVRDTESVLIPNP-QNRVE DFIFEKIEK-----SK-PK--RLSNLEHLALDMIEAGGDFGQD-LPY-G---QALIKVGQ AEQKLGQCEHDFIATSGICFTQPLRKFLDGEMKTI------------------------- -----GKERGILETKRLDLDACKNRV-KK---ARSMLGQQSKDG-ISPEA---------- -------------VLE-QA--ERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAF IQTQVRYYKQCGDVMEQLQRELA-------N----------------------LGGPT-- --P-----------------YIPLDVNEA---------SASKSNISSGAAARGPGN---- -------------------------------------------------NHSAN----MA ATGHKPNQPMHV-----------STDQMQRARV---LC----SYDAKDHTELNL-SANE- --VIFVTECSPVN-EDYMYGKQ---GLLKGLV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PRAFVEMLDEEHDVTL----------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000014331 -----------------------------------M--------DLTRLAVDAGQFINRA V--QYTEESLGQAEKTE-VDPGLDELFAR--VDATKRWTDQIISQTEVLLQPNS-GARLE DRLYEHLDW-----SV-PP--RPRAHEVLGDQMTQAGLEMGSN-TPY-G---TALLRCGD AQKQLGEAERKFVQSTNIHFLSPLRSFTEGEYGAM------------------------- -----QAERKMLVNKRLDLDIAKTRL-RK---AHEADREGRNLNANPLEEDYLSHVSYMF SFLRVKWLKMWAQEIS-QA--ETEQRICQSLFDRQSENTRRVVEGINSTHTNHMRSLTEF VEGQACYFDQCNQHAQELKRQLA-------S------------------------IPA-- --V-----------------FCSNNWQSAISA---------------------EVT---- -------------------------------------------------QPSTN----GH VAN----------EHVGLNGVV-PIPKVVHQIL---DF----DQDSWTNPPTAT-EAKK- --DLSVTTQPNNN-NNNNNNSL---SSDEQATSHWSVINLGLDHVCTSNLSQISTLGRTA SAQTNAAAAGRSNGAGSQTTTTSP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PSDISGNES------------------------------------ --------------------------------------------------------- >T_rubripes_ENSTRUP00000035306 -----------------------------------M--------ELTRLAADAGQFINRA V--QYTGENLGQADRTE-LDPGLEELLAL--ADATKTCTDKIVSQTEVLLQPNP-GSRFE DRLYEQLDW-----RI-PS--RPRAQESLGEQMIQAGLEMGPN-TPY-G---KALLRCGE AQKQLGEAERKFVQSTNILFLTPLRNFTDAEYRSI------------------------- -----QDERRMLLNKRLDLDIAKTRL-KK---AHEAESEAT----TEPEHEPSGNRLFVS SLLHV---QMWAQEIS-QA--EMELRICESLFRRQSEVTRQVVEGIGQTHTHHMQILTDF VEAQASYFDQCNQHTQDLQKHLA-------S------------------------SLAGV FIV-----------------LAASQQCSA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITGSQP-------------------------------------- --------------------------------------------------------- >A_carolinensis_ENSACAP00000002466 ------------------------------------------------------------ L--QFTEEKLGQAEKTE-LDAHFENLLAR--ADSTKNWTEKIQHQTEVLLQPNP-STRVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMIEAANDFGPT-SPY-G---KTLIKVGE TERRLGGAERDFIHSASINFLTPLRNFLEGDWRTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAA----AVPDFNETRPRNYIL SASAS---ALWSDEVE-KA--EHELRMAQTEFDRQAEVTRLLLEGISSTHV--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000022641 ------------------------------LQGAAM--------DVTRLAADAGQFLNRA V--QYTGETLGQADRTE-LEPGLEELLAL--ADATKTSTDKILSQTEVLLQPNP-GTRLE DRLYEQLDW-----RI-PP--RPGAHELLGDQMIQAGLEMGPN-TPY-G---KALLRCGE AQKQLGEAGRKFVQSTTILFLNPLRNFTEAEYRSI------------------------- -----QDERRTLLNKRLDLDVAKARL-KR---AHEAEREAT------------------- ------------------A--EMELRICESLFRRQSEVTRQVVEGISHTHNNHMQTLTDF VEAQASYFHQCHQHAQELQKHLA-------S------------------------IPA-- --V-----------------LCSNNWQSA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000029955 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------G---STLIKVGD CQRRLGGAEREFLQASSISFLTPLRNFLEGDWRTI------------------------- -----SRERRLLENRRLDLDACKARL-KK---AKAAEAKAA----AVPDFQETRPRNYVL SASAS---ALWSEELD-KS--EQELRVAQAEFDRQAEVTRLLLEGISSTHVNHLRCLREF AEAQAMYYNQCHKYMQELQRELG-------RR-----------------------CPD-- --S-----------------LEVNCEPSGSPS--------------DLLNSPSP------ ------------------------------------------------------------ ---------LDS-DTLQIEEVQPPASGTRKARV---LY----DYTAADSSELSL-RADE- --LITVYTMPGMD-SDWLIGER---GNQKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >T_guttata_ENSTGUP00000017496 ------------------------------------------------------------ L--QFTEEKLGQAEKTE-LDAHFENLLAR--ADCTKNWTEKILRQTEVLLQPNP-SARVE EFLYEKLDR-----KV-PS--RVTNGELLAQYMTEAANDFGPG-TPY-G---KTLIKVGE TQRRLGAAEREFIRSASISFLTPLRNFLEGDWRTI------------------------- -----SKERRILQNRRLDLDACKARL-KK---AKAAEAKAA----VTP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >G_gorilla_ENSGGOP00000014938 ------------------------------------------------------------ ----FTEEKFGQAEKTE-LDAHFENLLAR--ADSTKNWTEKILRQTEVLLQPNP-XXXXX XXXXXXXXX-----XX-XX--XXXXXXXXXXXXXXXXXXXXXX-XXX-X---KTLIKVAE AEKQLGAXERDFIHTASISFLTPLRNFLEGDWKTI------------------------- -----SKERRLLQNRRLDLDACKARL-KK---AKAAEAKATCEGDTVPDFQETRPRNYIL SASAS---ALWNDEVD-KX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXX-------XSQGAV-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----SL APP-------GE-ASLCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADE- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >O_cuniculus_ENSOCUP00000000290 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------G----------- ------------------------------------------------------------ ---------------------------------------------TVPDFQETRPRNYIL SASAS---AXXXXXXX-XA--EQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF VKSQTTYYAQCYRHMLDLQKQLG-------SSQGAI-------------------FPG-- --T-----------------FVGTTEPAS-PP-----LSSTSPTTAAATMPVVP------ ---------------------------------------------------SVA----GL APP-------GE-AALCLEEVAPPASGTRKARV---LY----DYEAADSSELAL-LADK- --LITVYSLPGMD-PDWLIGER---GNKKGKV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYLELLS------------------------------------ --------------------------------------------------------- >O_anatinus_ENSOANP00000023039 ------------------------------------------------------------ ---QFTEEKFGQAEKTE-MDANFESLLAR--ADSTRNWTEKILHQTEVLLQPNP-SKRWE TLAGGVWSL-----ELPPA--RSPRPQVLRLKMCPRAKELAGP-APP-G---KTLTKVSE AEKQLGAAERDFIHSASINFLTPLRNFLEGDWRTI------------------------- -----SKERRLLQNRRLDLDACK-RL-KK---AKAAEARAA----AVPDFQETRPRNYIL SASAS---AV-----------------------------RL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------QRLV------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000018400 -----------------------------------------------MSVAGFRKQFYKA S--QMVSEKVGGAEGTK-LDEDFKDLERK--ADVTSKAVVELISKTSEYLQPNP-ATRAK LTMLGTVSKIRGQVKS-PG--YPQPEGLLGECMTKYGRDMGQN-TGF-G---GALIDFGE SMLRLAEVKDSLDIDVKQNFIDPLQTVADKDIKDI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IQ-------------------------- ---------------------DEEIRQALEKFHESKELAEGSMHNLLETDVEQVSHLSSL VESLVQYHRQASQILEELSENLAK-RNVQGRRTQSRP------------------KRE-- --------------------YTP-KPRPSFD-Y-GR--ADNSN------GGFTPAA---- ---TSPS--------NYS------------------------------------------ -------------------------AAEPCCRA---LY----DFEPENDGELGF-REGD- --VIRLLS--RID-ENWLEGSL---GSRSGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVNYVEVTVPLPN-------------------------------- --------------------------------------------------------- >H_sapiens_ENSP00000269886 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVTEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELAEKLKR-RM---REASSRP------------------KRE-- --------------------YKP-KPREPFD-L-GE--PEQSN------GGFPCTT---- ---APKI--------AASSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-HEGD- --VITLTN--QID-ENWYEGML---DGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >G_gorilla_ENSGGOP00000008017 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVTEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELAEKLKR-RM---REASSRP------------------KRE-- --------------------YKP-KPREPLD-L-GE--PEQSN------GGFPCTT---- ---APKI--------AASSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --VITLTN--QID-ENWYEGML---DGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000091264 -----------------------------------------------MSVAGLKKQFYKA S--QMVSEKVGGAEGTK-LDEEFKDLERK--VDVTNKAVVEVISKTSEYLQPNP-ASRAK LSMLNTMSKIRGQVKS-PG--YPQAEGLLGECMGKYGRELGEE-TNF-G---GALMEVGE SMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFHESKEVAEISMYNLLETDIEQVSQLSSL VESQLQYHRQAVQILDELSDKLESRRM---KDAQTRP------------------RKE-- --------------------YIP-KPKPVID-F-GE-TNEQSN------GGYTPSS---- ---APPM----------------------------------------------------- -------RN--------------AAAEQACCKA---LY----DFEPENEGELGF-HEGD- --IITLTN--QID-ENWYEGML---RGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVIVPLPH-------------------------------- --------------------------------------------------------- >B_taurus_ENSBTAP00000007890 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVTEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQAMEKFEESKEVAETSMHHLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELADKLKR-RM---REASSRP------------------KRE-- --------------------YKP-KPRELLD-L-GE--PEQSN------GGFPCAA---- ---APKI--------TASSSFRS------------------------------S----DK PVRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-HEGD- --IITLTN--QID-ENWYEGML---DGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >T_rubripes_ENSTRUP00000014694 ------------------------------------WEVHAFMFAQLVTTAGC--VLNPI L--QMVSEKVGGAEGTK-LDEDFKDLERK--ADVTSRAVVEIISKTSEYLQPNP-ATRAK LTMLSTVSKIRGQVNS-PG--YPQPEGLLGECMTKYGQDMGTN-TSF-G---GALMDFGE SMMRLAEVKDSLDIDVKQNFIDPLQTIADKDIKDI------------------------- -----QHHLKKLGSRRLDYDYKKKRQ-GK---IQ-------------------------- ---------------------DEEIRQSLEKFHESKDLAESSMHNLLETDVEQVSHLSSL VESLLQYHREASQILEVLSGNLAQ-RW---REP--------------------------- --------------------WAP-QGVAASG------------------TGCRYIY---- ---TQSIQ------MISSTVIEL------------------------------R----WF PGLTPPSSP--------------LSAAQPCCRA---LY----DFESQNDGELSF-REGD- --VINLLS--QID-ENWLEGSI---GGRSGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVNYVEVTV------------------------------------ --------------------------------------------------------- >E_caballus_ENSECAP00000022327 ------------------------------------------------------------ ---QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVAEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GR---IP-------------------------- ---------------------DEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELADKLKR-RM---REGSSRP------------------RRE-- --------------------YKP-KPREAFE-L-GE--PEQPN------GGFPCAT---- ---APKV--------TGSSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --IITLTN--QID-ENWYEGLL---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >C_familiaris_ENSCAFP00000028160 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDEDFKEMEKK--VDVTSKAVTEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GR---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLCAL VDAQLDYHRQAVQILDELADKLKR-RM---RDASSRP------------------KRE-- --------------------YKP-KPREPFD-L-GE--PEQSN------GGFPCAT---- ---APKI--------PASSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENAGELGF-HEGD- --VITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >M_domestica_ENSMODP00000001111 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVAEVLARTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRYGKELGDE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFVDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELADKLKR-RM---REASSRP------------------KRE-- --------------------YKP-KPRDSYD-F-GE--PDQSN------GGFPCAP---- ---APKIT-------AASSSFRS------------------------------S----DK PIRTPIRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --IITLTN--QID-ENWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >G_gallus_ENSGALP00000001688 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDLTSKAVTEVLTRTIEYLQPNP-ASRAK LTMLNTMSKIRGQVKN-PG--YPQSEGLLGESMIRYGKELGED-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELAEKLKR-RM---REASSRP------------------RRE-- --------------------YKP-KPRETYD-F-GE--SDQSN------GGFSCTP---- ---TPKV--------SASSSFR-------------------------------S----DK PFRTSVRSI--------------PHLDQPCCKA---LY----DFEPENDGELGF-KEGD- --IITLTN--QID-ENWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000013606 -----------------------------------------------MSVAGLKKQFYKA S--QMVSEKVGGAEGTK-LDDDFRDLERK--VEVTSKAVVEVISKTSEYLQPNP-ASRAK LSMLNTMSKIRGQVKN-PG--YPQAEGLLGECMSKYGRDLGEE-TNF-G---GALVDVGE AMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLKEI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEEVRQALEKFHESKEVAETSMYNLLETDIEQVSQLSSL VDSQLQYHRQAVQVLEELSDKLRD-RV---NEAQSRP------------------RRE-- --------------------YTP-KPKPIFD-F-GE--DSHSN------GGYSAPV---- ---ALPP--------SRTT----------------------------------------- -----------------------AALEQPSCKA---LY----DFEPENEGELGF-HEGD- --IITLTN--QID-ENWYEGML---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLIPLPH-------------------------------- --------------------------------------------------------- >M_musculus_ENSMUSP00000003268 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKDMEKK--VDVTSKAVAEVLVRTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMVRHGKELGGE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILEELADKLKR-RV---REASSRP------------------KRE-- --------------------FKP-RPREPFE-L-GE--LEQPN------GGFPCAP---- ---APKI--------TASSSFRS------------------------------S----DK PIRMPSKSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --LITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVQVLVPLPQ-------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000016230 -----------------------------------------------MSVAGFKKQFYKA S--QMVSEKVGGAEGTK-LDEDFKDLERK--VDVTSKAVVEVISKTSEYLQPNP-ASRAK LSMLNTMSKIRGQVKN-PG--YPQAEGLLGECMGKYGRDLGEE-TNF-G---GALVDVGE SMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEEVRQALEKFHESKEVAETSMYNLLETDIEQVSQLSSL VESQLQYHRQAVQVLEELSDKLKD-RM---NDAQTRP------------------RRE-- --------------------YTP-KPKPIYD-F-GE--DNQSN------GGYSTSA---- ---APPP--------SRNSG---------------------------------------S GIRVASHRK--------AT----SAPEQPCCKA---LY----DFDPENEGELGF-REGD- --VITLTN--QID-ENWYEGML---NSQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLVPLPH-------------------------------- --------------------------------------------------------- >T_rubripes_ENSTRUP00000005083 -----------------------------------------------MSVAGLKKQFYKA S--QMVSEKVGGAEGTK-LDDDFRDLERK--VEVTSKAVVEVISKTSEYLQPNP-ASRAK LSMLNTMSKIRGQVKN-PG--YPQAEGLLGECMTKYGRDLGEE-TNF-G---GALVDVGE SMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLKEI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEEVRQALEKFHESKEVAETSMYNLLETDIEQVSQLSSL VDSQLQYHRQAVQVLDELSDKLRD-RV---NEAQSRP------------------RRE-- --------------------YTP-KPKPIFD-F-GD--DSHSN------GGYSAPM---- ---APPP--------SRNTGRH-------------------------------F----LL SFILPPVSS--------------AALEQPSCKA---LY----DFEPENEGELGF-HEGD- --IITLTN--QID-ENWYEGML---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLIPLPH-------------------------------- --------------------------------------------------------- >O_latipes_ENSORLP00000004783 -----------------------------------------------MSVAGLKKQFYKA S--QMVSEKVGGAEGTK-LDDDFRDLERK--VDVTSKAVAEVISKTSEYLQPNP-ASRAK LSMLNTMSKIRGQVKN-PG--YPQAEGLLGECMAKYGRELGED-TNF-G---GALVDVGE SMKRLAEVKDSLDIDVKQNFIDPLQGLCDKDLREI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEEIRQALEKFHESKDVAETSMYNLLETDIEQVSQLSAL VDSQLQYHRQAVQVLEELSDKLRE-RM---NEAQSRP------------------RRE-- --------------------YTP-KPKPIFD-F-GD--NSHSN------GGYPTTM---- ---APPP--------SQNVSMRD------------------------------G----ES WRRTLSCSV--------YP----APPEQPSCKA---LY----DFEPENEGELGF-HEGD- --VITLTN--QID-ENWYEGML---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLVPLPH-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000029264 -----------------------------------------------LRTYCLKKNENKS NL-QRVSEKVGGAEGTK-LDVDFTEMEKK--VDTTSRAVLDILTKTTEYLQPNP-ATRAK MSMMSSMSKIRGGDKG-PG--YTQTETTLGEAMQKAGRELGEE-SCF-G---VALIDVGE AMRELGEVKDALDMEVKQNFIDPLQNIHDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---VT-------------------------- ---------------------EDEIKQALEKFDDSKEIAEQSMFNLLENDIEQVSQLSAL VQAQVNYHRQAAEILQQLSSKIED-RI---REASCKP------------------KRE-- --------------------YVP-KPRTSLD-F-----SENHN------GSIGHSG---- ----P------------------------------------------------------- -----SRSP--------GISFVSAPMDQPCCRA---LY----DFDPENEGELGF-KEGD- --IITLTS--KID-DNWYEGMV---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVNYVDILVALPH-------------------------------- --------------------------------------------------------- >O_latipes_ENSORLP00000025092 -----------------------------------------------------------S S--QKVSEKVGGAEGTK-LDDDFKEMEKK--VDITSRAVLDIMTKTTEYLQPNP-ASRAK LSMINTMSKIRGQDKG-PG--YPQAETILGDAMLKFGRELGEE-SSF-G---MALIDAGE SIKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---VQ-------------------------- ---------------------DEEIKQALEKFDESKEIAEQSMFNLLESDIEQVSQLAAL VQAQLEYHSRAAEILQQLSSKMED-RI---KEVSSKP------------------RKE-- --------------------YSP-KPRMTLE-LLPP--SESHN------GGIHSAK---- ---SP------------------------------------------------------- -----GRSPVYTSRIGFDSHSLAAPMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-DNWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >T_rubripes_ENSTRUP00000020281 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFREMEKK--VDVTSRAVLDIMTKTTEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAETVLGDTMLKFGRELGED-SSF-G---SALIEASE AMKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---VQ-------------------------- ---------------------DEEIKQALEKFDESKEIAEQSMFNLLESDIPEVSQLAAL VQAQLEYHRRSAEILQQLSSKMED-RI---KEASCKP------------------RKE-- --------------------FTP-KPRMTLE-LLPP--SESHN------GGIHSAK---- ---SP------------------------------------------------------- -----GRSP--------------APMDQPCCRA---LY----DFEPENDGELGF-KEGD- --IITLTN--QID-DNWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >X_tropicalis_ENSXETP00000039086 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDEFKEMEKK--VDVTTKAVTDVLAKTIEYLQPNP-ASRAK LSMLNTMSKIRGQVKN-PG--YPQPEGVLGETMIKFGKDLGDE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFLDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQAMEKFIESKEVAETSMINLLDTDVEQVSQLTAL VEAQLDYHRQAVQILDELSEKLKD-RV---RESSSRT------------------KRE-- --------------------FKP-KPRESYE-Y-AE--SEQSN------GGFS-NP---- ---SSKA--------PASSSFR-------------------------------S----EK PARTNNRSS--------------APLDQPCCKA---LY----DFDPENDGELGF-RESD- --IITLTN--QID-ENWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVNYVEILVPLPQ-------------------------------- --------------------------------------------------------- >O_anatinus_ENSOANP00000005301 -----------------------------------------------FAILHLEKYFSYL L--QKVSEKVGGAEGTK-LDEDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDE-CNF-G---PALGDVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQASQILQQVTVRLEE-RI---RDASSQP------------------RRE-- --------------------YQP-KPRMSLD-F-STGDNAQHN------GGLSHTG---- ---TP------------------------------------------------------- -----KPTG--------------VPMDQPCCRA---LY----DFDPENEGELGF-KEGD- --VITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVALPH-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000069441 -----------------------------------------------LSCHGYSDEFSWI H--FLMSEKVGGAEGTK-LDEDFKDLERK--ADITSKAISDVLCKTTEYLQPNP-ASRAR LTMANTMSKMRGQVKS-LG--YPQAEGLLGECMLKYGRDMGED-TNF-G---GALVEMGE AMKRLAEVKDSLDIDVKQNFIDPFQTIVDKDLKDI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IA-------------------------- ---------------------DEELRMAMEKFEESRDAAETSMQNLLDTDVEQVSQLCAL VESQLQFHKQSMQVLEELAGAMRE-RV---NKAQSQP------------------RQK-- --------------------RMP-VSRPSID-Y-SD--PEDSN------GGWNPSA---- ---AAPP--------SYSSTAAP-----------------------------------SF NRASSRQKR--------------NSADQPCCRA---LY----DFEPENEGELGF-NEGD- --VITLTN--QID-DNWYEGSF---RGQTGLF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PCNYVEVMVPLR--------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000020231 -----------------------------------------------MSVAGFKKQFYKA S--QMVSEKVGGAEGTK-LDEDFKDLERK--ADITSKAVVEILNKTTEYLQPNP-ATRAK LSMVSTVSKMRGQGNG-PG--YPQPEGLLGECMTKYGRDMGEE-TNF-G---GALTDIGE SMKRMAEVKDSLDIDVKQNFIDPLQAVAEKDIKDI------------------------- -----QYQLKKLEGRRLDYDYKKKRQ-GK---IQ-------------------------- ---------------------DEEIRQALEKFHESKETAEASMYNLLETDVEQVSQLSSL VESLLQYHKQASEILEELTGKLRE-RV---NEAQSRP------------------RRE-- --------------------YTP-RPRPSYD-Y-GE--VEESN------GGYAPAA---- ---SSPP--------AYS------------------------------------------ -------------------------PAEPCCKA---LY----DFEPENEGELGF-HEGD- --IITLVN--QID-DNWFEGAI---RGRSGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PNNYVEVMVPLQH-------------------------------- --------------------------------------------------------- >H_sapiens_ENSP00000369981 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-PTGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPSG--------------VQMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGHSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >P_troglodytes_ENSPTRP00000035569 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-PTGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPSG--------------VQMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGHSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >T_guttata_ENSTGUP00000004600 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMAKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLADAMLKFGRELGEE-CNF-G---PALVDVGE AMKELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---LP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQATQILQRVTSKLED-RI---KEASSQP------------------RRE-- --------------------YQP-KPRMSLD-F-STGDNTQHN------GGISHAT---- ---TP------------------------------------------------------- -----KPSG--------------VHMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPN-------------------------------- --------------------------------------------------------- >M_musculus_ENSMUSP00000032874 -----------------------------------------------MSVAGLKKQFHKA S--QLFSEKISGAEGTK-LDEEFLNMEKK--IDITSKAVAEILSKATEYLQPNP-AYRAK LGMLNTVSKLRGQVKA-TG--YPQTEGLLGDCMLKYGKELGED-SAF-G---NSLVDVGE ALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLRKLEGRRLDYDYKKRRV-GK---IP-------------------------- ---------------------EEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALDYHRQSTEILQELQSKLEL-RI---SLASKVP------------------KRE-- --------------------FMP-KPVNM---------SSTDA------NGVGPSS---- ---SSKT----------------------------------------------------- -----PGTD--------------TPSDQPCCRG---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---RGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPP-------------------------------- --------------------------------------------------------- >H_sapiens_ENSP00000320092 --------------------------MDGIF-------------AGIICNQANRCLTWTS Q--QLFSEKISGAEGTK-LDDEFLDMERK--IDVTNKVVAEILSKTTEYLQPNP-AYRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLKYGKELGED-STF-G---NALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF IEAALDYHRQSTEILQELQSKLQM-RI---SAASSVP------------------RRE-- --------------------YKP-RPVKR---------SSSEL------NGVSTTS---- ---VVKT----------------------------------------------------- -----TGSN--------------IPMDQPCCRG---LY----DFEPENQGELGF-KEGD- --IITLTN--QID-ENWYEGMI---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >B_taurus_ENSBTAP00000018755 -----------------------------------------------MSVAGLKKQFHKA T--QKLGEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-STGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPAG--------------APMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >C_familiaris_ENSCAFP00000002279 -----------------------------------------------VNTAGMKWVASGI Q--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-TTGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPAG--------------APMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >E_caballus_ENSECAP00000008025 ------------------------------------------------------------ ---QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-PTGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPAG--------------APMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >X_tropicalis_ENSXETP00000039083 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDEDFKEMERK--VDVTSRAVMEIMTKTTEYLQPNP-ASRAK LSMLNTMSKIRGQEKG-PG--YPQAEALLAEAMFKFGREIGDE-SNF-G---LALIDVGD AMRELSDIKDCLDIDVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IT-------------------------- ---------------------DDEIRQALEKFDESKEIAESSMFNLLEMDHFAVFNEPSI LYIVMEYYYYCITYRIYLNICIKFYRI---REASSQP------------------RRE-- --------------------YQP-KPRMSLE-L----ENSQLN------GGIALAG---- ---TP------------------------------------------------------- -----KPSG--------------APMDQPCCRA---LY----DFDPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >A_carolinensis_ENSACAP00000017453 ------------------------------------------------------------ ---QKVSEKVGGAEGTK-LDEDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LTMLNTMSKIRGQEKG-PG--YPQAEALLAEAMIKFGKELGDE-CNF-G---PALGDVGE AMRELSEVKDSLDIDVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---LP-------------------------- ---------------------DDELRQALEKFDESKEIAESSMFNLLEMDVEQVSQLTAL VHAQLEYHKQATQILQQVSSRLEE-RI---KDASLQP------------------RRE-- --------------------YQP-KPRMSLD-F-SS-DNPQHN------GGINTAT---- ---TP------------------------------------------------------- -----KPSG--------------VGMDQPCCRS---LY----DFDPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVPLPR-------------------------------- --------------------------------------------------------- >O_latipes_ENSORLP00000018713 -----------------------------------------------MSVAGLRKQINKA T--QMINEKVGGAEGTK-LDEDFKELERK--ADITSKAMLEVISKTTEYLQPNP-ATRAK LTMLNTVSKIRGQVKS-PG--YPQPEGLLGEAMLKYGRDMGDD-TNF-G---GALLDVGE TMKRMAEVKDSLDIDVKQNFIDPLQAVADKDIKDI------------------------- -----QHHLKKLEGRRLDYDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFHESRDLAETSMYNLLETDVEQVSQLSAF VDSLLQYHQEATQILQELNGRLKE-RV---SDAQSRP------------------KRE-- --------------------IPK-KRQESFE-Y-GH-EQDDSN------GGYSPAA---- ---INPP--------SYSAGKRE------------------------------D----IK PTETIIVML--------GY----KNKTDPCCKA---MY----DFEPENDGELGF-REGD- --IITLVS--KID-ENWYEGRL---QGRSGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PTNYVEVMVPLPY-------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000024519 ------------------------------------------------------------ ---QKVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSRAVLDIMTKTTEYLQPNP-ASRAK LSMINTMSKIRGQDKG-PG--YPQAESVLGDAMLRFGRELGDE-SSF-G---LALIDASE AMKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---VQ-------------------------- ---------------------DDEIKQALEKFDESKEVAEQSMFNLLESDIEQVSQLAAL VQAQLEYHSRSAEILQQLSSKMED-RI---KEVSAKP------------------RKE-- --------------------YAP-KPRMTLE-LLPP--SESHN------GGIHSAK---- ---SP------------------------------------------------------- -----GRSP--------------APLDQPCCRA---LY----DFEPENEGELGF-KEGD- --VITLTN--QID-DNWYEGMI---NGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPR-------------------------------- --------------------------------------------------------- >P_troglodytes_ENSPTRP00000012631 --------------------------MDGIF-------------AGIICNQANRCLTWTS Q--QLFSEKISGAEGTK-LDDEFLDMERK--IDVTNKVVAEILSKTTEYLQPNP-AYRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLKYGKELGED-STF-G---NALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF IEAALDYHRQSTEILQELQSKLQM-RI---SAASSVP------------------RRE-- --------------------YKP-RPVKR---------SSSEL------NGVSTTS---- ---VAKT----------------------------------------------------- -----TGSN--------------IPMDQPCCRG---LY----DFEPENQGELGF-KEGD- --IITLTN--QID-ENWYEGMI---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >M_domestica_ENSMODP00000018579 ------------------------------------------------------------ ---QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDE-CNF-G---PALGDVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQASQILQQVTVRLEE-RI---REASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-SSGDNSQHN------GGLSHTS---- ---TP------------------------------------------------------- -----KPSG--------------APMDQPCCRA---LY----DFEPENEGELGF-KEGD- --VITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >M_mulatta_ENSMMUP00000015364 ------------------------------------------------------------ ---QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASAQP------------------RRE-- --------------------YQP-KPRMSLE-F-PTGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPSG--------------VQMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGHSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >C_familiaris_ENSCAFP00000019543 ------------------------------------------------------------ S--QLFSEKISGVEGTK-LDDEFLDMERK--IDITNKAVAEILSKATEYLQPNP-AYRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLKYGKELGEG-STF-G---NALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF IEAALDYHKQSTEILQELQSKLQM-RI---SAASSVP------------------KRE-- --------------------YKP-RPIKR---------SPSFK------LGISSQA-NDS ILHTSTS----------------------------------------------------- -----SGSN--------------VAMDQPCCRG---LY----DFEPENQGELGF-KEGD- --VITLTN--QID-ENWYEGML---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >G_gallus_ENSGALP00000024312 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMAKTIEYLQPNP-ASRAK LSRGDTMSKIRGQEKG-PG--YPQAEALLADAMLKFGRELGEE-CNF-G---PALADVGE AMKELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---LP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQATQILQRVTSKLED-RI---KEASSQP------------------KRE-- --------------------YQP-KPRMSLD-FTSGGDNTQHN------GGISHAT---- ---TP------------------------------------------------------- -----KPAG--------------AHMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPN-------------------------------- --------------------------------------------------------- >T_rubripes_ENSTRUP00000026652 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFTEMEKR--VDTTSRAVLDIMTKTTEYLQPNP-ATRAK MSMMNSMSRMRGQEKG-PG--YTQTEAILGESMQKFGRELGEE-SSF-G---LALVDIGE AMRELGEVKDALDMEVKQNFIDPLQNLHEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---VT-------------------------- ---------------------EDELKQALEKFDDSKEIAEQSMFNLLECDIEQVSQLAAL VQAQLEYHSRSAEILTQLSSKIDE-RI---REASGKP------------------RKE-- --------------------FAP-KPRTSLD-F-SI--SENHN------GGIHGAR---- ---SPAPP------PPPFAARSP------------------------------A----LH RSPGVSRS---------------APMDQPCCRA---LY----DFDPENEGELGF-KEGD- --IITLTN--KID-DNWFEGML---HGNSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDTLVPLP--------------------------------- --------------------------------------------------------- >B_taurus_ENSBTAP00000023954 ------------------------------------------------------------ ---QLFSEKISGVEGTK-LDDEFLDMERK--IDITNKAVAEILSKATEYLQPNP-AYRAK LGMLNTMSKIRGQVKT-TG--YPQTEGLLGDCMLKYGKELGEG-STF-G---SALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALDYHRQSTEILQELQSKLQM-RI---SAASNVP------------------KRE-- --------------------YKP-RPIKR---------SPSEL------NGVSTAS---- ---SAKT----------------------------------------------------- -----TGSN--------------VPMDQPCCRG---LY----DFEPENQGELGF-KEGD- --IITLTN--QID-ENWYEGIL---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >O_latipes_ENSORLP00000008947 -----------------------------------------------LNTSGIREEFPVL L--QRVSEKVGGAEGTK-LDDDFTVMEKR--VDTTSRAVMDVITKTTEYLQPNP-ATRAK MSMMNSMSRMRGQEKG-PG--YTQTEAVLGESMQRFGRELGED-SSF-G---LALIDVGE AMRELSDVKDALDMEVKQNFIDPMQNLHEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---VT-------------------------- ---------------------EDEIKQALEKFDDSKEIAELSMFNLLESDIEQVSQLAAL VNAQLEYHSRSTEILTQLSSKMDE-RI---REASGKP------------------RKE-- --------------------YVP-KPRPSLD-F-SI--TETHN------GGMHGAR---- ---SPVSC------NTLYL----------------------------------------- -----SKSP--------------APLDQPSCRA---LY----DFDPENEGELGF-KEGD- --IITLTN--KID-DNWYEGML---HGNSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >G_gallus_ENSGALP00000009724 -----------------------------------------------MSVAGLKKQFHKA S--QLFSEKISGAEGTK-LDEEFQEMERK--IDVTNKAVAELLSKSTEYLQPNP-AYRAK LGMLNTMSKIRGQVKT-TG--YPQTEGLLGDCMIRYGRELGDD-SMF-G---LALLDAGE SMKQMAEVKDSLDINVKQNFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRL-GK---IP-------------------------- ---------------------DEEVKQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALDYHKQSTEILEDLQSKLQN-RI---NVASSRP------------------KRE-- --------------------FKP-KPVITTTLE-TG--DNQQH------NGIAYSS---- ---SIKS----------------------------------------------------- -----SGSS--------------MHVDQPCCQA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---NGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVMVPLPQ-------------------------------- --------------------------------------------------------- >A_gambiae_AGAP004766-PA -----------------------------------------------MAFAGLKKQINKA N--QYVTEKMGGAEGTK-LDLDFMEMERK--TDVTVELVEELQAKTKEYLQPNP-TARAK MAAVK--------------------EGILADCMLTYGKKLGED-SIF-A---SALVEMGD SLKQMADVKYSLDDNIKQNFLEPLHQLQTKDLKEV------------------------- -----MHHRKKLQGRRLDFDCKKRRQ-AKGSQIT-------------------------- ---------------------DDEIRSAEEKFAESLQLAQVGMYNLLENDVEQVSQLVTF AEGMLDYHSQCSEILKVLVETLNE-KR---EEAAARP------------------KSE-- --------------------FVP-KTLADLN-IEMLGSQDGM------------------ -------------------NASP------------------------------L----PS PMRSPARTP------------MPTKPTQPCCTA---LY----DFEPENPGELGF-KEND- --VITLIQ--RVD-ENWFEGSL---NGRNGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PQSYVQVTVPLPSN------------------------------- --------------------------------------------------------- >X_tropicalis_ENSXETP00000034478 -----------------------------------------------MSVAGLKKQFHKA S--QLFSEKISGAEGTK-LDDDFQEMERK--IDITNKVVAELLSKTTEYLQPNP-AYRAR LGMLNTMSKIRGQVKT-TG--YPQTEGLLGDCMLRHGRELGDE-SEF-G---CALLDAGE CMKQMAEVKDSLDINVKQNFIDPLQSLQDKDLKEI------------------------- -----LYHLKRLEGRRLDYDYKKRRQ-GK---IP-------------------------- ---------------------DEEIRQAVEKFEESKELAERSMFNFLENDIEQVSQLSVF VEAALDYHRQSAQILEDLHNRLHN-RM---NTASSRP------------------KRE-- --------------------LQH-KSIIATL-E-SN--EKLHH------NGIPSNS---- ---SIKP----------------------------------------------------- -----SGSS--------------GNLDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWFEGMV---NGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVVVPLP--------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000018950 ------------------------------------------------------------ ---QLLSEKISGAEGTK-LDEDFMEMERK--IEVTNKSVFDLLSKTTEYLQPNP-ASRAK LNMLNTVSKMRGQVSP-TG--YPQTEGLLGDCMLRHGHELGED-SVF-G---CALVEMGE AMRQMADVKDALDIGVKQNFIDPLQNVQDKDLKEI------------------------- -----THHLKKMEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEEIRQAVEKFDESRELAERSMFNFLENDVEQVRQLLAL IQAAAEYHRQSRDILQELSGKLQK-RI---STASSRP------------------RRD-- --------------------FHQ-KSIRSSM-Q-PV--DSGQH------NGLSFSS---- ---SLRA----------------------------------------------------- -----SGTG--------------EPLDQPCCRS---LY----DFEPENEGELGF-KEGD- --VIILTN--RID-DNWYEGMI---SGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVLVPLP--------------------------------- --------------------------------------------------------- >A_carolinensis_ENSACAP00000001464 ------------------------------------------------PWRGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDLTSKAVVEVLARTTEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGESMIRYGKELGEE-SNF-G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELADKLKR-RV---REASSRP------------------KRE-- --------------------YKP-KPRETYE-F-GE--SDQSN------GGFSCNP---- ---APKV--------SASSSFR-------------------------------S----EK PSRTPSRT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000001004 -----------------------------------------------MSVAGLKKQFHKA TQ-QKVSEKVGGAEGTK-LDDDFTEMEKR--VDVTSRAVLDIMTKTTEYLQPNP-ATRAK MSMMNSMSRMRGQEKG-PG--YTQTEAILGESMQKFGRELGEE-SSF-G---LALVDIGE AMRD-GEVKDALDMEVKQNFIDPLQNLHEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-AK---VT-------------------------- ---------------------EDELKQALEKFDDSKEIAEQSMFNLLESDIEQVSQLAAL VQAQLEYHSRSAEILTQLSSKIDE-RI---REASGKP------------------RKE-- --------------------FVP-KPRTSLD-F-SI--SENHN------GGIHGAR---- ---SPVIS------GARSPARSP------------------------------G-----E ASPLPARSP--------------APMDQPCCRA---LY----DFDPENDGELGF-KEGD- --IITLTN--KID-DNWFEGML---HGNSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDTLVPLPH-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000005975 ------------------------------------------------------------ ----LLSEKISGAEGTK-LDEDFMEMERK--IEVTNKSVFELITKTTEYLQPNP-ASRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLRYGRELGEE-SAF-G---TALADIGE AMKQMADIKDALDISVKQNFIDPLQNLQDKDLKEI------------------------- -----VHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEEIKQAVEKFEESKELAERSMFNFLENDVEQVSQLSAL IEAALEYHRQSLEILKDLDSKLQN-RI---STASRRP------------------KKE-- --------------------FKP-KSIVSSL-E-SV--ENTQH------NGLSHTS---- ---SIKS----------------------------------------------------- -----TELE--------------SHMDQPCCRS---LY----DFEPENEGELGF-KEGD- --IIILTN--QID-ENWYEGMI---NGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDVLVPLPQ-------------------------------- --------------------------------------------------------- >E_caballus_ENSECAP00000009970 --------------------------MSQPRGPAERRDHPARPGAVAMSMAGLKKQFHKA S--QLFSEKISGVEGTK-LDDEFLDMERK--IDVTNKAVAEILSKATEYLQPNP-AYRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLKYGKELGEA-STF-G---DALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAAF IEAALDYHKQSTEILQELHSKLQI-RI---TAASNLP------------------KRE-- --------------------YKP-RPIKR---------SPSEL------NGVSATS---- ---STKT----------------------------------------------------- -----TGSN--------------VPMDQPCCRG---LY----DFEP-NQGELGF-KEGD- --VITLTN--QID-ENWYEGML---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >A_aegypti_AAEL002469-PB -----------------------------------------------MAFAGLKKQINKA N--QYVTEKMGGAEGTK-LDLDFMEMERK--TDVTVELVEELQAKTKEYLQPNP-TARAK MAAVKGISKLSGQAKS-NT--YPQPEGILADCMLTYGKKLGED-SIF-A---GALVEMGD SLKQMADVKYSLDDNIKQNFLEPLHQLQTKDLKEV------------------------- -----MHHRKKLQGRRLDFDCKKRRQ-AKGSQIT-------------------------- ---------------------DDEIRSAEEKFAESLQLAQVGMYNLLENDVEQVSQLVTF AEGLLEFHSQCADILRVLVETLNE-KR---EEAASRP------------------KSE-- --------------------FVP-KTLADLN-IETLGSQDGMN------GGSSSRLNSPV NKPTHLELLGNGQAQARSTNASP------------------------------L----PS PMRSPARTP------------MPAKPTQPCCTA---LY----DFEPENPGELGF-KEND- --VITLIQ--RVD-ENWFEGSV---NGRTGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PQSYVQVTVPLP--------------------------------- --------------------------------------------------------- >O_anatinus_ENSOANP00000020362 ------------------------------------------------------------ ---QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVAEVLTRTIEYLQPNP-ASRAK LTMLNTVSKIRGQVKN-PG--YPQSEGLLGECMIRYGKELGDE-SKFGG---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEEMRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VEAQLDYHRQAVQILDELADKLKS-RM---REVSSRP------------------KRE-- --------------------YKP-KPRESYE-F-GE--PDQSN------GGFPSAP---- ---APKVT------DTASSSFRS------------------------------S----DK SVRTPSRSM--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >D_melanogaster_FBpp0083113 -----------------------------------------------MAFAGLKKQINKA N--QYMTEKMGGAEGTK-LDMDFMEMERK--TDVTVELVEELQLKTKEFLQPNP-TARAK MAAVKGISKLSGQAKS-NT--YPQPEGLLAECMLTYGKKLGEDNSVF-A---QALVEFGE ALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEV------------------------- -----MHHRKKLQGRRLDFDCKRRRQ-AK------------------------------- ---------------------DDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTF AEALYDFHSQCADVLRGLQETLQE-KR---SEAESRP------------------RNE-- --------------------FVP-KTLLDLN-------LDGGG------GGLNEDGT--- --PSHI-----------SSSASP------------------------------L----PS PMRSPAKSM----------AVTPQRQQQPCCQA---LY----DFEPENPGELAF-KEND- --IITLLN--RVD-DNWFEGAV---NGRTGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PQSYVQVQVPLPN-------------GN----------------- --------------------------------------------------------- >O_latipes_ENSORLP00000023765 -----------------------------------------------MSMAGLRKQLHKA S--QSPTEWVGPADGLR-VVRASGTVNKK--MEVTHKGLADLLSRTTEFLQPNP-ASRAK LNMLNTVSKIRGQVKT-TG--YPQTEGMLGDCMVRHGYELGED-SAF-G---GALVDVGE AMRQMGDLKDSLDINVKQKFLDPLQNLQDSDLKEI------------------------- -----THHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEEIRQAGEKFEESKELAERSMFYFLENEVEQLRQLSGL VEAALDYHRQSAEVLQVLSRKLQK-RI---STASGRP------------------RGG-- --------------------FKS-RRSSVEC-L-----DGGQR------SSLTHCS---- ---SLKSTGTPPGSLWSSPR--------------------------------------ST KQLLSAAEG--------------EVPDQPCCRA---LY----DFDPENDGELGF-REGD- --TIILAN--QLD-QNWYEGMI---NGDAGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVNYVEVIIPLPQ-------------------------------- --------------------------------------------------------- >R_norvegicus_ENSRNOP00000026870 ------------------------------------------------------------ -------------------------FLKK--IDITSKAVAEILSKATEYLQPNP-AYRAK LGMLNTMSKLRGQVKA-TG--YPQTEGLLGDCMLKYGRELGED-SAF-G---NSLVEVGE ALKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLRKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------EEEIRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALDYHRQSTEILQELQNKLEL-RI---ALASQVP------------------RRD-- --------------------YMP-KPVNT---------SSTNA------NGVEPSS---- ---SSKL----------------------------------------------------- -----TGTD--------------IPSDQPCCRG---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---RGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPR-------------------------------- --------------------------------------------------------- >M_musculus_ENSMUSP00000102806 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-ATGDSTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPPG--------------VQMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENCRLLVLVLIPATENLT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTNIVAVSQETPH-------------LRMTILQVNNSKNGVLPGT GVFCLATHVLLERAEVTGQMLQTSGMDLCEEAASRMGRRVEWTSGGRGASTYLFNNG >T_nigroviridis_ENSTNIP00000008151 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFREMEKK--VDVTSRAVLDIMTKTTEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAETVLGDTMLKFGRELGED-SSF-G---SALIEASE AMKELGEVKDALDMEVKQNFIDPLQNLHDKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---VQ-------------------------- ---------------------DEEIKQALEKFDESKEIAEQSMFNLLESDIEQVSQLAAL VQAQLEYHRRSAEILQQLSSKMED-RI---KEASCKP------------------RKE-- --------------------FTP-KAAADAG-A-AA--PQREP------QRRAPQR---- ---PGPP----------------------------------------------------- -----------------------GRSPSGCSKRRVWLPGHSTDFEPENRGRAGLRRRDD- --VITLTQ--PRSSDKLVRGHD--PTATRASS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPR-------------------------------- --------------------------------------------------------- >C_elegans_T04D1.3d -----------------------------------------------MSLSGLRKQFNKA N--QYLSETMGAAEPTK-LDDVFNEMEKN--VDTTYNLITDLVAGTNEYLQPNP-ATRAK MATQVALSKVRGTTKT-SP--YPQTEGMLADVMQKYGQQLGDN-SDL-G---KSLNDAAE TYRQMADIKYQMEDNVKQNFLDPLTHLQNNELKDV------------------------- -----NHHRTKLKGRRLDYDCKKRQQ-RR------------------------------- ---------------------DDEMIQAEEKLEESKRLAEMSMFNVLSNDVEQISQLRAL IEAQLDFHRQTAQCLENLQQQLGH-RI---KDAAARP------------------REE-- --------------------HVP-LSVLANESRTPRSSFRSPAP-----SDMSHNS---- ---TAAAAFKMPPQNGGGITQAP------------------------------P----SY QGPPPGGLP-----------PPLSQQQKPQCRA---LF----DFDAQSEGELDF-KEGT- --LIELVS--QID-ENWYEGRV---NGKTGLF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVTYVQVLVPLK--------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000022977 ------------------------------------------------------------ -------------------------MEKK--MDTTARAVMDIITKTTEYLQPNP-ATRAK MSMMNSMSRMRGQEKG-PG--YTQTEVILGESMQRFGRELGEE-SNF-G---LALIDAGE AMRELGEVKDALDMEVKQNFIDPMQNLHEKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRS-GK---VT-------------------------- ---------------------EDELKQALEKFDDSKEIAELSMFNLLESDIEQVSQLAAL VHAQVEYHSRAAEILTQLSSKIDE-RI---KDTTVKP------------------RKE-- --------------------FAP-KPRTSLD-F-SI--SENHN------GGLHGAR---- ---SP------------------------------------------------------- -----ARSP--------------APLDQPCCRS---LY----DFDPENEGELGF-KEGD- --IITLTN--KID-DNWYEGML---NGNSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000005989 -----------------------------------------------MSVAGLKKQFHKA S--QLLSEKISGAEGTR-LEEDFVEMERK--IDVTNKSIVELLSKTIEYLQPNP-ASRAK LNMLNTVSRIRGQVRT-NG--YPQAEGLLGDCMLRYGQELGED-SVF-G---GALVETGE GLRQMADVKDALDVSVKQNFIDPLQNLQDKELKEI------------------------- -----THHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------GDEIQQAAEKLEESKALAERSMFNFLESDMEQVSQLASL IEAAKEYHRQSCKILEELFGKLQK-RI---SSASFHP------------------RKE-- --------------------FKP-KSIREAM-T-VF--DNSPH------DSPSRSA---- ---SMKSS---------------------------------------------------- -----GPAS--------------EVLDQPCCRS---LY----DFEPENEGELGF-KEGD- --VIILTN--QID-ENWYEGMI---HGRA-FF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PISYVEVMVPLPQ-------------------------------- --------------------------------------------------------- >P_pygmaeus_ENSPPYP00000010546 ------------------------------------------------------------ ----LVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVAEVLARTIEYLQPNP------ ------------------------------------------------G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLDYHRQAVQILDELAEKLKR-RM---REASSRP------------------KRE-- --------------------YKP-KPREPFD-L-GE--PEQSN------GGFPCTT---- ---APKI--------AASSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --VITLTN--QID-ENWYEGML---DGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >M_domestica_ENSMODP00000035386 ------------------------------------------------------------ -------------------------LFQK--IDVTHRAFIELLPKCIEYLQPNP-AYRMK LGVMQTVFKITGQLKN-QP--YPHSEGMLGDCMLRYGSELGEE-SLF-G---ESLLDCGE TMMLMSDIKEALDINVKQNFLDPVQLLEAREIKDI------------------------- -----ERNLRKLESRRLDYDYIKRRDISI---IH-------------------------- ---------------------PEELQVAGGKFEESKELVRTSMTNFLENDIEQVNQLAVF IEALLEYHRQNTEILEDLYRKLHH-RI---LFCSLMP------------------FSM-- --------------------YFS-FPVFTSP-TTFKNFKKENN------LGTCPS----- ------------------------------------------------------------ -----------------------FANVVPCCRG---LY----DFAAEHEEELGF-KEGD- --IITITS--QVD-ENWYAGIL---EGKYGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PITYVEVLVPLPS-------------------------------- --------------------------------------------------------- >T_rubripes_ENSTRUP00000036096 -----------------------------------------------MSVSGMKKQLHKA N--QLLNEKLMGAEGTK-LEEDFLKMQRS--TAVIHSLLTELLPKTTEFLQPNP-ADRTK LNLLNTMSRIRGQGKS-VG--YPQTEGILGDCMLQYGHALGAA-SEF-G---GALLGMGE TLHQVAQARDALGVNVKCTFIDPLQDLHDTELKEI------------------------- -----KYQLKKVNSQRLDFDYKKRRS-GK---IP-------------------------- ---------------------AGELQQAWRKFVTSKELAERSMFVLLQNDVDHLRILAAL VTALLDFHRSAHHILLGLHGNMQA-RL---TAASNKP------------------ERR-- --------------------FRP-GKVSRAQLSFAV--NDGLN------TVQSVRS---- ------------------------------------------------------------ ISILPADSK--------------LVLDQPCCRA---TY----SFHPNQEGELDF-SEGD- --IIVLTK--QVD-VNWYEGTL---GSQSGLF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVCYVDVLVPLPL-------------------------------- --------------------------------------------------------- >M_mulatta_ENSMMUP00000033337 -----------------------------------------------MSVAGLKKQFHKA S--QLFSEKISGAEGTK-LDDEFLDMERK--IDVTNKAVAEILSKTTEYLQPNP-AYRAK LGMLNTVSKIRGQVKA-TG--YPQTEGLLGDCMLKYGKELGED-STF-G---NALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF IEAALDYHKQSTEILQELQSKLQM-RI---SAASSVP------------------RRE-- --------------------YKP-RPVKR---------SASEL------NGVSTTS---- ---VVKT----------------------------------------------------- -----TAYS---------------------------------RLEPAD------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >D_rerio_ENSDARP00000067629 -----------------------------------------------MSVAGLKKQFHKA TQ-QKVSEKVGGAEGTK-LDDDFKEMEKK--VDTTSRAVLDIMTKTTEYLQPNP-GESVX MLISQSLY------------------------------------VTL-F---LVCVDLGE SMRELGEVKDALDITVKQNFIDPLQNLHDKDLKEI------------------------- -----QHHLKKMEGRRLDFDYKKKRQ-GK---VT-------------------------- ---------------------DDEIKQALEKFDESKEIAEQSMFNLLENDIEQVSQLAAL VQAQVEYHQQAAEILQQLSSKIEDSRV---KEMSDKP------------------RKE-- --------------------FIP-KPRMELQ-L-PI---ETLN------GGINSAK---- ---SP------------------------------------------------------- -----ARSP--------------APLDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-DNWYEGMI---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVDILVPLPH-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000007836 -----------------------------------------------MSVAGFKKQFHKA S--QLLKEKINGVEGTK-LDEEFLSMERK--TEITHKLILDIVPKTIGYLQPNP-AYRAK LSMLSTVSRIRGHVKA-VG--YPQTEGILGDCMLQYGSELGAE-SGF-G---FALLEMGE ALKQVAQARDCMDVRVKRAFIDPLQSLQQKELKEI------------------------- -----GFHLRKLEGRRLDFDYKKRRK-GK---IA-------------------------- ---------------------DSEIKKAFDKFEESKEMAERCMFNLLEKDVQRMQHLSGL LEAVIDYHRQSSQILENLRSNLQT-KI---RDASNKP------------------KRE-- --------------------FAS-KSVASTVCYSDIYGFSTCS------SGPSSDTE-IT EALSEKYAPVVVHRPEQVTIKTP------------------------------T----TD KPASINDRA--------------PPLDQPCCQA---LY----SFQAENQGELGF-KEGD- --IIILTS--QID-ENWYEGMI---RGQSGLF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PMNYVKVLVPLPQ-------------------------------- --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000005236 -----------------------------------------------MSVSGMKKQLHRA N--QLLNERLMGAKGTK-LEEDFLKMERS--VAVIHALLTELLPRTTAFLQPNP-ADRAR LSVLNAVSRLRGRARR-VG--YPQTEGLLGDCMLQYGQELGAA-SEF-G---GALSGAGE ALHLVAQARDALLVDVKCTFIDPLQGLHDSQLKEI------------------------- -----RDQLKKVSSRRLDFDYKRRRS-GK---VP-------------------------- ---------------------AGELQQAWGKFVTSRELAEGSMFALLQNDVDQLRILASL VTALLDFHRNAHRILLGLHGNLQT-RL---TAASNEP------------------QRR-- --------------------FRP-AKMRLGSEVSGL--QRQRP------GPALLRQ---- ------------------------------------------------------------ APVRTANT---------------LVLDQPCCRA---MY----SFHPNQDGELDF-SEGD- --LIVLTK--QVD-VNWYEGTL---GGRSGLF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PVCYVDVLVPLPL-------------------------------- --------------------------------------------------------- >T_guttata_ENSTGUP00000007997 -----------------------------------------------MSVAGLKKQFHKA S--QLFSEKISGAEGTK-LDEEFQEMERK--IDVTNKAVTELLSKSTEYLQPNP-AYRAK LGMLNTMSKIRGQVKT-TG--YPQTEGLLGDCMIRYGRELGDD-SMF-G---LALLDAGE SMKQMAEVKDSLDINVKQNFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRF-GK---IP-------------------------- ---------------------DEEVKQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALDYHKQSTEILEDLQSKLQN-RI---NVASSRP------------------KRE-- --------------------FKP-KP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >P_pygmaeus_ENSPPYP00000007649 ------------------------------------------------------------ ----LFSEKISGAEGTK-LDDEFLDMARK--IDVTNKVVAEILSKTTEYLQPNP------ ------------------------------------------------G---NALIEVGE SMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEI------------------------- -----GHHLKKLEGRRLDYDYKKKRV-GK---IP-------------------------- ---------------------DEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF IEAALDYHKQSTEILQELQSKLQM-RI---SAASSVP------------------RRE-- --------------------YKP-RPVKR---------SSSEL------NGVSTTS---- ---VAKT----------------------------------------------------- -----TGSN--------------IPVDQPCCRG---LY----DFEPENQGELGF-KEGD- --IITLTN--QID-ENWYEGMI---HGESGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEVIVPLPQ-------------------------------- --------------------------------------------------------- >T_guttata_ENSTGUP00000000840 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQAMEKFEESKEVAETSMHNLLETDIEQVSQLSAL VDAQLEYHRQAVQILDELAEKLKR-RF---RAGSQLSGGIRWLVSDAAEVGTQECRQE-- --------------------HQPCQPRQGAE---------PVA------GGRAVWG---- ------------------------------------------------------------ -PRVPTILA--------------APLDQPCCKA---LY----DFEPENDGELGF-KEGD- --IITLTN--QID-ENWYEGMI---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLNYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >P_troglodytes_ENSPTRP00000017525 -----------------------------------------------MSVAGLKKQFYKA S--QLVSEKVGGAEGTK-LDDDFKEMEKK--VDVTSKAVTEVLARTIEYLQPNP------ ------------------------------------------------G---DALLDAGE SMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFEESKEVAETSMHNLLETD---------- --------------------------M---REASSRP------------------KRE-- --------------------YKP-KPREPFD-L-GE--PEQSN------GGFPCTT---- ---APKI--------AASSSFRS------------------------------S----DK PIRTPSRSM--------------PPLDQPSCKA---LY----DFEPENDGELGF-REGD- --VITLTN--QID-ENWYEGML---DGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PLSYVEVLVPLPQ-------------------------------- --------------------------------------------------------- >R_norvegicus_ENSRNOP00000008999 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QHHLKKLEGRRLDFDYKKKRQ-GK---IP-------------------------- ---------------------DEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSAL VQAQLEYHKQAVQILQQVTVRLEE-RI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-ATGDGTQPN------GGLSHTG---- ---TP------------------------------------------------------- -----KPAG--------------VQMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >O_cuniculus_ENSOCUP00000001028 -----------------------------------------------MSVAGLKKQFHKA T--QKVSEKVGGAEGTK-LDDDFKEMERK--VDVTSRAVMEIMTKTIEYLQPNP-ASRAK LSMINTMSKIRGQEKG-PG--YPQAEALLAEAMLKFGRELGDD-CNF-G---PALGEVGE AMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREI------------------------- -----QXXXXXXXXXXXXXXXXXXXX-XX---XX-------------------------- ---------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXX-XI---RQASSQP------------------RRE-- --------------------YQP-KPRMSLE-F-LTGDSTQPN------GGLSHTS---- ---TP------------------------------------------------------- -----KPAG--------------APMDQPCCRA---LY----DFEPENEGELGF-KEGD- --IITLTN--QID-ENWYEGML---HGQSGFF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PINYVEILVALPH-------------------------------- --------------------------------------------------------- >C_intestinalis_ENSCINP00000024816 ----------------------------------------------TMSLGGMKKQLNKA S--QYMSEKMGETEKTK-MDEEFIEMERVSCLDATQKAVTDLINHTREYLQPNP-AVRAK MNMMNKL-----QGKD-MK--YRQVEGVLGEVMVKHGTDLGHE-SNF---------EVGE GMIQLSEIKDSLDVSVKQDFIDPFYQSFDKDMKEVLVESRHISTHFKLWGLGKFQCTKLL RYSDSKHHRKKLSGRRLDYDYKRKKG-AK---VP-------------------------- ---------------------HEEVVQAEQKLDESLELAGSSMFNLLAGDVEQVRQLAAL VEAQLEYHRQSADILESVNDKLNK-QI---EEINSKP------------------EKR-- --------------------TKR-QLRTSSIAPADR--TPTHT------TPAIPQA---- ---SPRHTAPPPKGDFSMLTFPKYCWVNHHKCTLKILFLILPLEYLLIYTKFNN----VA LAVRLEKFK--------------TPTTQPSCKA---IF----DFEPENEGELAF-KEGE- --ILTLVA--EID-DNWFEGMS--QNGDTGYF---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PKTYVEVVVPL---------------------------------- --------------------------------------------------------- >G_aculeatus_ENSGACP00000014307 ---------------------------------------------------KMKKQFNRM R--QLANQTVGRAEKTEVLSEDLLQVEKR--LDLVKQVTHGTHKKLTACLQGQQ-GADIE -----KRSK-----KL-PL-------TILAQCMVEGAAVLGDD-SLL-G---KMLKLCGE TEEKLAEELIQFEFQIERDVVEPLYVLAEVDIPNI------------------------- -----QKQRKHLAKLVLDMDSSRTRF-HQ---SSKSSGHPSTLQP-GAKSESL------- ---------------------REEMEEAANRMEICRDQLSADMYSFVAKEIDYANYFQTL IETQAEYHRKSLEILQSILPQIKA-HQ---EAWVEKPSFGKSLEEHLNIS-----GREIA FPVEACVTMLLECGMQEEGLFRVAPSASKLKKLKASLDCGVMDVQEYSSDPHAIAA---- --------K-GALKSYLRELPEPLMTTELYDEWIQASNVQDMDKRLQALMAVCD----KL PTDNLNNFRYLVKFLSKLSDYQDANKMTPGNMA---IVLGPNLLWTHTEPNMTEMMTTLS LQIVGIIE-PIIQHADWFFPGD-IEFNLTGSYGSPIHTNHNSNYSSMPSPDMDQSERKQP HDQSRRPLSVATDNMMLEFYKKDGIRKIQSMGVRVMDTSWVSRKGSATLVRKTSSTPPGM QGPGSPADTLLPEQSGEFATSPSTTPPPG------------------------------- --ERACSLKSKELSP-----VIGH------------------------------------ KAI-QVAGPT------------------------VPPSCSLHSSIQS------------L HSTEHSPH----------------------TLRKGSKKLAPVP-P--------------- -----------------------KVPYS------------------------QSCGMSDQ ST--------GQPSPV-SLSPTPPSTPSPYGLVCPPGLVPPSSPGQT---------SPPS LGGTLTKS-RPALS-PGRRPSLPPPQPAHRIPGVHWPGPWSRAPSPWSRA-SWMDSL-PG RSMSTDIF-NYEIPSFNVNLDSLIDEFSGAPCRRSVAVTDSPEGDAVPEEEPLSTTL >O_anatinus_ENSOANP00000006460 ------------------------------------------------------------ ---------------------------QK--IDITNKAVGELLSKSTEYLQPNP-AYRAK LGMLNTVSKIRGQVKT-TG--YPQTEGLLGDCMLRFGKELGEE-SSF-G---AALIDVGE SMKLMAEVKDSLDINVKQNFLDPLQLLQDKDLREI------------------------- -----GHHLKKLEGRRLDYDYKKKRI-GK---VP-------------------------- ---------------------DEEVKQAVEKFEESKELAERSMFNFLENDVEQVSQLAVF VEAALNYHRQSTDILEELHGKLQS-RY---QSS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >O_latipes_ENSORLP00000015712 ----------------------------------------------------MKKQFNRM R--QLANQTVGRAEKTEVLGEDLLQVEKR--LELVKQVSHSTHKKLTACLQGQQ-GVDVE -----KKSK-----KL-PL-------TTLAQCMVEGAVVVGDE-SLL-G---KMLKLCGE TQERLAQELILFELTIERDVVDPLCELAEVEIPNI------------------------- -----QKQRKHLAKLVLDMDSARTRY-YQ---STKSSGVSTNLQPTGAKADHL------- ---------------------REEMEEAANRMEICRDQLSADMYSFVAKEIDYASYFQTL IEVQAEYHRKSLELLQSVLPQIKA-HQ---ETWVEKPCYGKPLEEHLVLS-----GRDIA FPIEACVTMLLECGMEEEGLFRIAPSASKLKKLKASLDCGVLDVQEYSADPHAIA----- ----------GALKSYLRELPEPLMTFQLYSDWIQASNIQDHEKRLQALYAACE----KL PPANNNNFKYLIKFLSKLTEYQDLNKMTPGNIA---IVLGPNLLWTHNDGNITEMMTTVS LQIVGIIE-PIIQHADWFFPGE-IEFNVTGNYGSPVHTNHNANYSSMPSPDMDQTDRRQ- NDQSRRPLSVATDNMMLEFYKKDGIRKIQSMGVRVMDTSWVSRRGSSS-SRKSSSTPPNV HPPTPPADAIIPEQPGDFYVSPSPTPPPT-SSDRA-----------------------SL VPSLLSTLKNKELSP-----VIGQ------------------------------------ KGL-QGTVPC---------------------------------SGQS------------Q HS-EHSPH----------------------SLRR-AKKLAPIP-P--------------- -----------------------KGPFC------------------------QMGAMSDQ ST--------GQPSPV-SLSPTPPSTPSPYGFSYPQGYATISSPCQTQTATTPSLSSPPS LAGTLNKP-RPIPKPPRQRPNLPPPQPP------STPGT---SPQPLDHSSGLLDGLSPG ESMSTDTFCNLDIPVIDMELESILDLAHISPFRNLVTLLESTNSRADSEEESESTVL >T_rubripes_ENSTRUP00000026216 ----------------------------------------------------MKKQFNRM R--QLANQTVGRAEKTEVLSEDLLQVEKR--LDLVKQVTHSTHKKLTACLQGQQ-GADTE -----KRSK-----KL-PL-------TTLAQCLIEGAAVLGDD-SLL-G---KMLKLCGE TEERLAQELIQFEFQIERDVVEPLCLVAEVDIPNI------------------------- -----QKQRKHLAKLVLDMDSARTRY-QQ---SSKSSSHPSSLQP-GTKSESL------- ---------------------REEMEEAANRMEICRDQLSADMYSFVAKEIDYANYFQTL IETQAEYHRKSLEILHSILPQIKA-HQ---EAWVEKPSFGKSLEEHLNIS-----GREIA FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKASLDCGIVDVQEYSSDPHAIA----- ----------GALKSYLRELPEPLMTLELYDEWIQASNVQDMDKRLQTLMSTCE----KL PTDNLNNFRYLIKFLAKLSDYQDANKMTPSNMA---IVLGPSLLWTHTEPNMTEMMTTLS LQIVGIIE-PIIQHADWFFPGE-IEFNLTGSYGSPIHTNHNSNYIPMPSPDIDQSEHKQQ HDQSRRPLSVATDNMMLEFYKKDG------MGVRVMDTSWVSRKGSATLARKTSSTPPGM PGSG-PGDALIPEQPGELGASLLGTPPPA------------------------------- --ERLCICSANNVSPNRSDTSHGHPPPGEDRPPPPYPTSSCNT----------AQHHFYP KAP-PCARPVAPGPESQPPGSPPPPLRWSGFTPPAPPPLSSSSSSSSSLDINSNPKPSCL HFPKHSPPGEILHAPPPDANASPLYIKTPLVLARHDPSLGN-P-P--------------- -----------------------SLPSSVPPPWAACPCIRERGPPRLTRLPTQSGGLSDQ ST--------GQPSPV-SLSPTPPSTPSPYGLVCPSGQMPPPSPGQTPLGTTHSLSSPPS LTGTLTKS-RPAPK-PRQRPSLPPPQPP-------------------------------- --------------------------------------------------------- >D_rerio_ENSDARP00000045712 ----------------------------------------------------MKKQFNRM R--QLANQTVGRAEKTEVLSDDLLQIERR--MELVRVVSHNTHKKMAVCLQGQI-GTDAE -----KRHK-----KL-PL-------TALSQAMQDGGNQLGEE-SLI-G---KMMEMCGD AENRLASELMQHEMNIEKEILDPLNQLAEFDIPNI------------------------- -----LKQRRQLAKLVLDYDSARARW-LQ---ATKSIISGTNTQALTAKADSL------- ---------------------KEEVDEAMNKMELCKDQLSADMYNFFSKEADYARYYVML LEAQADYHRKSLTLLESVLPNIQA-QQ---GDDTHS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >T_nigroviridis_ENSTNIP00000021162 ----------------------------------------------------MKKQFNRM R--QLASQNLGRAEKTEVLREDLLQIEKR--MELVRMVSHNSHKRLTSCLQGQL-GTDAE -----KRHK-----KL-PL-------TALSQTMQEGGGHLGDE-SLI-G---KMMEACGE AEGRLATELMQYEVQVERDILDPLNQLAEVEIPNI------------------------- -----LKHRKQLAKLVLDYDSAKTRW-YQ---ATKS-----TNQAMAAKVDSL------- ---------------------KDEMEEALNKVEACKDQLSVDLYSFASKEGDYARYFVLL LEAQADYHRRSLAALESALPTIQM-QQ---DSWMEKPAFGTALEEHLKRS-----NREIA LPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCSTSQLEEFYSDPHAVAA---- --------HTGALKSYLRELPEPLMTFGLYDEWTQASSVSDPDKRLQALWVTCN----SL PKPHKANLRYLVKFLSKLAQDSEVNKMTPSNIA---IVLGPNLLWAKTEGTLAEMAAATS VHVVAIIE-PIIQHADWFFPED-VDFNVSGMFALPSHPPTPDSDPG-----PER------ ----KRPPSQGGQDGDSQTPRKDS---P-----VNKQPVPAPRRASVINKK-PPLTSPTF QPTLPPLEAWVSAQPEPEPEV--PEAEQPGPGAGWPGRGDGGGGGLGGSVQVA-----PV KPQVVTQLSAEESSPARE------------------------------------------ ----LMSTPP--------------------------SQRNGL------ALLAVGTPQSQG GSRGASPH----------------------MVRRGTKKPAPAP-P--RQASPFTSQPSG- -----------------------THASSSSHHPPVTPRRNPSKDALI-----QSPSYPPP QPP--QAPQGES-------EPSPPSSPTP-----------PDTPTHDASTTN---PMAFY NSGSLPRPSRPAPR-PRPRPSMPPPPQP---------------------AANDNSNGSCG SASKIIT--GLTPACLKRS---------------------------------SGLAS >T_nigroviridis_ENSTNIP00000006694 ----------------------------------------------------MKKQFNRM R---LANQTVGRAEKTEVLSEDLLQVEKR--LDLVKQVTHSTHKKLTACLQGQQ-GADTE -----KRSK-----KL-PL-------TILAQCMVEGAAVLGDD-SLL-G---KMLKLCGE TEEKLAQELIQFEFQIERDVVEPLCVIAEVDIPNI------------------------- -----QKQRKHLAKLVLDMDSARTRY-QQ---SSKSSSHPSSLQP-GTKSESL------- ---------------------REEMEEAANRMEICRDQLSADMYSFVAKEIDYANHFQTL IETQA-YHRKSLEILQSILPQIKA-QQ---EAWVEKPSFGKSLEEHLNIS-----GREIA FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKASAGL-WWDVQEYSSDPHAIAE---- ----------GALKSYLRELPEPLMTLELYDEWIQASNIQDMDKRLQALMGTCE----KL PTDNLNNFRYLIKFLAKLSEYQDANKMTPSNMA---IVLGPSLLWTHTEPNMTEMMTTLS LQIVGIIE-PIIQHADWFFPGE-IEFNLTGSYGSPIHTNHNSNYIPMPSPDIDQSEHKQQ HDQSRRPLSVATDNMMLEFYKKDGIRKIQSMGVRVMDTSWVSRKGSATLARKTSSTPPGM PGSG-PADTLIPEQPGELGASASVTPPPALSGPSW-----------------------NG TPVKIFSLKSKELSP-----VIGH------------------------------------ KAI-QVAGPT------------------------VPPSSSPQSSNQS------------P HSTEHSPH----------------------TLRKGSKKLAPAP-P--------------- -----------------------KVPYS------------------------QSGGLSDQ ST--------GQPSPV-SLSPTPPSTPSPYGLVCPSGQMAPPSPGQTPLGAPHSLSSPPS LTGTLTKS-RPAPK-PRQRPSLPPPQPPTASSGLSAP-----APGLQPLEQGFLDGLSPG DSMSTDIF-NYEIPSINVNLDSLIDEFSGVPCRRSMAVTDSSEGSAVTEEEPQSTTL >O_latipes_ENSORLP00000011408 ----------------------------------------------------MKKQFNRV R--QLASQTVGRAEKTEVLSDDLLQIEKR--MELVRLASHSVHKRLVSCMQGGV-GIEAE -----RRHK-----KL-PL-------MALSQAMLDGGSSLGDD-GLI-GMRSKMMELCGD KEKLLANELVQHEVQIEKEILDPLNQLAEEEIPNI------------------------- -----LKQRKQLAKLVLDYDSAKARY-KA---AKSN-----NSQAMAGKLEPL------- ---------------------KDEMDEALNKVEICKDQLSADLYNFASKEGDYARYFVML LEAQADYHRKSLAALEAAMPDIQK-KQ---DSLTEKPAFGTALEEHLKRT-----NRDIA LPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCSTSQLEEFYCDPHAVA----- ----------GALKSYLRELPEPLMTFGLYEEWVQASSFTDSDKRLQSLWTTCS----RM PKNHKANFRYLVKFLARLAQDSDVNKMTPSNIA---IVLGPNLLWSKTEGTLAEMAAATS VHVVSIIE-PIIQHADWFFPEE-VNFNVTGMFNKSSHPATPDPEPN-----LDR------ ----KRPGSM-GLDGDSHAPRKDS---P-----ALKHPEPAPRRANTVNKKQSPLTSPIL QHPPVLLEAGAPPQLEPQTQMATPEVEQPGLSS-----GGSGGGALGGGFHIA-----AV HPQVVTQLSAEDSSLTRE------------------------------------------ ----FTTTPP--------------------------MQRNGS------AHLVVG----MS GSKGPSPH----------------------MVRRGTKKQAPAP-PPTKQTTHVASQSTN- -----------------------TQIPSSPH--PTTPRRNLSKDA-I-----QAPSHPPP QPPPVHQPQEDP-------EPSPPSSPMP-----------PDTLPHDGS-------LPSY PSGSLPRPSRPAPK-PRMRPSMPPPPQP---------------------PGIETGNGVCS SSSKIITDGGLVIKAIGRSLIPQVL--MEKKDSAGQESASHLAPNPEPSRPAESTAL >T_rubripes_ENSTRUP00000028273 ----------------------------------------------------KKLQINRS R--PSRRRSSVLAEKTEVLSEDLLQVEKR--LELVKQVSHSTHKKLTACLQGQQ-GVDVD -----KKSK-----KL-PL-------TTLAQCMVEGAAVLGDE-SLL-G---KMLKLCGE TQDKLAQELIMFELTIERDVVEPLNDLSEMEIPNI------------------------- -----QKQRKHLAKLVLDMDSARTRY-YQ---STKSSGLSSNLQPSGAKADHL------- ---------------------REEMEEAANRMEICRDQLSADMYSFVAKEIDYASYFQTL IEVQAEYHRKSLELLQSILPQIKA-HQ---ESWVEKPCYGKPLEEHLALS-----GRDIA FPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKASLDCGVLDVQEYSADPHAIA----- ----------GALKSYLRELPEPLMSYELYNDWIQASNIQDQDRRLQALHSACE----KL PAANNNNFKYLIKFLSKLTEHQDVNKMTPGNIA---IVLGPNLLWMNNEGNITEMMTTVS LQIVGIIE-PIIQHADWFFPGE-IEFNVTGNYGSPVHTNHNANYSLVPSPDMDQVDRRQ- NDQSRRPLSVATDNMMLEFYKKDG------MGVRVMDTTWVSRRGPST--RKCSSTPPSV HPFAPPIDAPIPEQPGEFSASPSLTPPPT-SSERASHQEGSQPFMCLRPLLTPLTPLTSA DPSDPSSLCSDDASSNWSDSCYVYPSPEEERPPPPYPFSSSSSCSSSCSSHSLPHHHFYT RAASPGARPVAPGPESVPPG----------------PSAPTRRTGYS--------PPPFL HSLCPSPQ----------------------QLD--TPRMRPCPTP--------------- -----------------------TAPPSISNPRSFSPVTS------------YSPAPQDP PTPPYLLPLHGQPVPVASLSPTPPSTPSP-------------------MATTPSLSSPPS LAGTLTKA-RPVPKPPRQRPSLPPPQPP------TTPGT--------------------- --------------------------------------------------------- >O_latipes_ENSORLP00000003838 ----------------------------------------------------MKKQFNRM K--QLANQTVGRAEKTEVLSDDLLQIERR--MELVRVVSHNTHKKMASCLQGHI-GAEAE -----KRHK-----KL-PL-------TALSQAMMEGGNQLGED-SLI-G---KMMEVCGD AENRLASELMQHELQIEKDVLDPLSQLAEVEIPNI------------------------- -----LKQRKQLAKLVLDYDSAKARW-LQ---ATKSIISGTNTQALTAKADLL------- ---------------------KEEVDEAMNKVELCKDQLAADMYSFFSKEGDYARYFITL LEAQADYHRKSLTVLESVLPTIQA-QQ---GTKTQR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------- >T_rubripes_ENSTRUP00000008291 ----------------------------------------------------MKKQFNRM R--QLASQNLGRAEKTEVLSDDLLQIERR--MELVRLVSHNSHKRLASCLQGQL-GTDAE -----KRHK-----KL-PL-------TALSQTMQEGGGHLGDE-SLI-G---RMMEACGE AEGRLASELMQHEVQIERDVLDPLNQLAEIEIPNI------------------------- -----LKQRKQLAKLVLDYDSAKTRW-YQ---ATKS-----TNQAMAAKVDSL------- ---------------------KDEMEEALNKVEICKDQLSADLYSFTSKEGDYARYYVML LEAQADYHRRSLAALEAALPTIQM-QQ---DSWLEKPAFGTALEEHLKRS-----NRDIA LPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCSTSQLEEFYSDPHAV-A---- --------DTGALKSYLRELPEPLMTFGLYDEFTQACNVSDPDKRLQALWVTCD----RL PTTHKANLRYLVKFLSKLAQDSEVNKMTPSNIA---IVLGPNLLWAKTEGTLAEMAAATS VHVVAIIE-PIIQHADWFFPED-IEFNVSGMFALPSHPPTPDSD-------PDR------ ----KRLTSQGGQDGDNQPPRKDS---PPLPSTVNKQPVPAPRRASAKTQR--------- -----------------------------------------------GGDQVR------- ------------------------------------------------------------ ------------------------------------RARNGL------GFLAVGTPHSQG GSRGASPH----------------------MVRRGTKKPAPAP-P--KQASPFASQPSG- -----------------------T--SSPSHHPPVTPRRNPSKDALI-----QSPSYPPP QPP--QAHQGES-------EPSPPSTPTP-----------PDTPPHDSSTTN---PLLSY NFGSLPRPSRPAPR-PRPRPNMPPPPQP---------------------AANDNSSDNCG SASKIITDGGLMLKGLGRTIIPVVIPHQEAGSSAGQERTATPAP-PIDSDTQESTAL >T_rubripes_ENSTRUP00000043320 ----------------------------------------------------MKKQFNRM K--QLANQTVGRAEKTEVLSDDLLQIERR--MELVRVVSHNTHKRMVSCLQGHI-GTDAE -----KRHK-----KL-PL-------TSLSQAMVEGGNQLGED-SLI-G---KMMEVCGE AENRLASELMHHELQIEKDVLDPLSQLAEVDVPNI------------------------- -----LKQRKQLAKLVLDYDSARARW-LQ---ATKSIISGTNTQALTAKADLL------- ---------------------KEEMDEAMNKVELCKDQLAADMYSFSSKEGEYALYFVTL LEAQADYHRKSLTVLENVLPTIQA-QQ---DSWTEKPAFGTGLDEHLKRS-----GREIA LPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCSTSQLEEFYSDPHAVA----- ----------GALKSYLRELPEPLMTHLLYDEWIQASSVSDPDKRLQALWVVCN----KL PKNNKTNLRYLVRFLSKLAHDSEANKMTPSNIA---IVLGPNLLWAKTEGSLAEMAAATS VHVVAIVE-PIIQHADWFFPEE-VDFNVSGMFAMPAPTSNHNNHADYDCGTIER------ ----KRPQSMVGTDSD--VARKDN---S-----STKHSDHTLRRGSTTLGR-KQHTSPAF QPPLPPVEAPGQGHGAGQVPSAESQPQPQPPP------GGSGPDACQNSLQQG------- ---LGALAAGNQKGRDAT------------------------------------------ ----PAPTPL--------------------------LQRNGSGGGGGQAGGQVGSGTPGA GTMGPSPH----------------------MVRRGTKKQAPAP-P--KPLNPPPNQPCNS ANPPSSSSQPFSPSPRPLSNQSPTSPTSPPPQPCATPRRHSNNQPLI-----QAPSHPPP EPPTQPASPGQSSGDQQITDPSPPGTPTP-----------PGTPPPSTNTQDVAVPPSPY QFGSLPRP-RPVPK-PRSRPNIPPPPQP-------------------------------- ---------------------------------------------------------