10 20 30 40 50 60 70 80 90 100 110 120 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000083664 --------------------------------------------------------------------------------------------------MLGECGMTKWERLALRRNSVKM G_aculeatus_ENSGACP00000013740 ------------------------------------------------------------------------------------------------------CGMQERDRLALRTRSTVL O_latipes_ENSORLP00000015114 ------------------------------------------------------------------------------------------------RSVTQKCGMQKRDAEALRNCSVCL T_rubripes_ENSTRUP00000037606 ------------------------------------------------------------------------------------------------RSKMLHCGMREQDARTLRRQSAVL T_nigroviridis_ENSTNIP00000010874 ---------------------------------------------------------------------------------------------------MLQCGMVERDAQALKKQSAVL G_gallus_ENSGALP00000029853 ----------------------------------------------------------------------------------------------------GACGMQRYHQEALKKNRVML T_guttata_ENSTGUP00000013612 --------------------------------------------------------------------------------------------------MLAACGMQRCHQEALKKNRVML A_carolinensis_ENSACAP00000006831 ------------------------------------------------------------------------------------------------SRMLGVCGMQKCHQEALKKNRVSL E_caballus_ENSECAP00000003321 -------------------------------------------------------------------------MAAPSAPSLPALQQKGLMAADRGRRILGVCGMHPDHQEALKKNRVVL M_musculus_ENSMUSP00000031895 -------------------------------------------------------------------------MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL R_norvegicus_ENSRNOP00000022672 -------------------------------------------------------------------------MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVL B_taurus_ENSBTAP00000024166 -------------------------------------------------------------------------MAAPSAGFQYPLQPKEQMAADRGRRMLRGCGMHPDHQEALKKNRVVL P_pygmaeus_ENSPPYP00000020323 -------------------------------------------------------------------------MAAPTAGSWSTFEHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL X_tropicalis_ENSXETP00000015203 ----------------------------------------------------------------------------------------------------MLGGMQKHHKDALQRLRVTL H_sapiens_ENSP00000312664 -------------------------------------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL P_troglodytes_ENSPTRP00000033921 -------------------------------------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL C_familiaris_ENSCAFP00000005409 -------------------------------------------------------------------------MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVL M_mulatta_ENSMMUP00000016588 -------------------------------------------------------------------------------------------------RILGVCGMHPHHQETLKKNRVML M_domestica_ENSMODP00000001598 -------------------------------------------------------------------------------------------------RMLGVWGMEQEHQEALKKNRVVL O_anatinus_ENSOANP00000005545 --------------------------------------------------------------------------------------------------------MQPCHQEALKKNRVAL O_cuniculus_ENSOCUP00000001859 -------------------------------------------------------------------------MAAPSAGSRASLQQKGLLAADRGRRITAVCGMHPDHQETLKKNRVVL C_intestinalis_ENSCINP00000002956 -------------------------------------------------------------------------------------------------------AMKKRHRNTLIKNRVKL C_intestinalis_ENSCINP00000007986 --------------------------------------------------------------------------------------------------------MLSTHKEKLRTNRHTL G_gorilla_ENSGGOP00000003520 -------------------------------------------------------------------------MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVL O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 --------------------------------------------------------------------------------------------------------MEERQRRALRRGRARL D_rerio_ENSDARP00000047019 --------------------------------------------------------------------------------------------------------MEQKHRQILQRHRLNL M_domestica_ENSMODP00000004412 --------------------------------------------------------------------------------------------------------MEESQRELFQKNRLRL G_gallus_ENSGALP00000002083 --------------------------------------------------------------------------------------------------------MEEAQRSALRRGRVRL G_aculeatus_ENSGACP00000007379 --------------------------------------------------------------------------------------------------------MEEIHKRILQRNRINL B_taurus_ENSBTAP00000003205 --------------------------------------------------------------------------------------------------------MNEADRLLLRRYRVRL P_pygmaeus_ENSPPYP00000002138 --------------------------------------------------------------------------------------------------------MDEADRRLLWRCRLRL H_sapiens_ENSP00000365051 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL P_troglodytes_ENSPTRP00000056642 ---------------------------------------------------------------------RGGRPWGGGGSWGLGRAAEARKRTEAAWSLSWLLAMDEADRRLLRRCRLRL M_mulatta_ENSMMUP00000040583 --------------------------------------------------------------------------------------------------------MDEADRRLLRRCRLRL T_rubripes_ENSTRUP00000045375 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRTNL M_musculus_ENSMUSP00000030747 --------------------------------------------------------------------------------------------------------MDEADRQLLRRCRVRL E_caballus_ENSECAP00000015102 --------------------------------------------------------------------------------------------------------MNEADRQLLRRSRLRL T_nigroviridis_ENSTNIP00000013855 --------------------------------------------------------------------------------------------------------MEERHKKILQRNRINL C_familiaris_ENSCAFP00000023986 --------------------------------------------------------------------------------------------------------MDEAERRALRRCRVRL D_rerio_ENSDARP00000075318 --------------------------------------------------------------------------------------------------------MADQLLENLRPDLIKG A_carolinensis_ENSACAP00000015721 -------------------------------------------------------------------------------------------------------AMEESHRALLRRNRVRL T_nigroviridis_ENSTNIP00000001216 --------------------------------------------------------------------------------------------------SAYQLFLSLCDQDHLSEERPHL R_norvegicus_ENSRNOP00000017972 --------------------------------------------------------------------------------------------------------MEEADRQLLRRCRVRL M_domestica_ENSMODP00000036247 -----------------------------------------------------------MDFHTFLYGIAEEIDSADLASLKFLCLDQIPLKKQQHIKDALVLFQTLEERGLLEEDNLFF C_elegans_C48D1.2 -------------------------------------------------------------------------------------------------------MMRQDRRSLLERNIMMF O_latipes_ENSORLP00000003208 --------------------------------------------------------------------------------------------------------MEEKHKRILRRNRVHL G_gorilla_ENSGGOP00000001932 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 -----------------------------------------------------------MDFSKCLYNIGEQLDSDELASLKFLSLDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLFF R_norvegicus_ENSRNOP00000016613 -----------------------------------------------------------MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSF M_musculus_ENSMUSP00000027189 -----------------------------------------------------------MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSF T_rubripes_ENSTRUP00000024467 ------------------------------------------------------------MDLRLLSQIDAQLDSLEVAALCFLCRDAVSPKSREGITDARGLFKKLHEKRLLE--NSSF T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 -----------------------------------------------------------MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSF T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013506 -----------------------------------------LKSFKPHWISSNMEDDDSLQFRQLLLLIDEGLGAEDVAALKFLCTDLIPFRKLESVQSAMDIFQLLIDEDYLNEEDTFL G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006164 -------------------------------ALVESGTVGDWVTVPGEGNGYXXXXXXXXXXXXXXXXXXEQLDSELL--LKF-ELDYIPQRKQEPIQDALMLFQRLQEKRMLEENNLAF T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 VEGGRRARVVTESKRNFFLGACPTPFPTEHVELGRLGGSETAMVPGKGGADYILLPFEEMDFNRNLYDIGEQLDSEELASLKFLSLDCIPQRKQEPIKDALMLFQRLQEKRMLEENNLSF O_anatinus_ENSOANP00000006351 -----------------------------------------------------------MDFHRLLFSIGEELAADDLEALKFLCLDLIPRKKQENIQDALGLFRLLQEKGMLEEGKLFF T_guttata_ENSTGUP00000010625 ------------------------------------------------------------DFRKLLFEVSEALVTEELSALKFLSLDHVPRRKLEAIHEPKAFFEVLQEKDMIGAGNLFF C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010722 ------------------------------------------------------------MDLQLLSRICEQLDSQEVASLCFLCREAVSKKSLEGINDARGLFKKLADQCLLE--NNSF P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 -------------------------------------------------------------FRQILLAIDENLGKEDVDAMKFLCSDFISTKHLEGVETAQDIFQLLINRNLLSKEDTFI M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004055 -----------------------------------------------------------MNFNSCLYNIGEQLDSDELASLKFLSLDHIPQRKQEPIQDALMLFQRLQEKRLLEESNLSF T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000351273 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF D_rerio_ENSDARP00000063081 -------------------------------------------------------------------------------------------------------MSKKESTQRILQHKVFL G_gallus_ENSGALP00000013591 -----------------------------------------------------------MEFSQLLFVISEALDRTELASLKFLSLEHVTVRKREDIEEPKAFFQALQEKGMIEVGDLFF G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044662 ---------------------------------------------------------CNMDFQARLLKVGNDLRKDEVRALVFLCSDILGCNP-AAVQSAGDLFSRLSDQDHLSEEQPHL X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000021879 MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF D_rerio_ENSDARP00000019984 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000000205 ---------------------------------------------------YILLPFEKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014606 -----------------------------------------------------------MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF H_sapiens_ENSP00000358327 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000005216 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 -----------------------------------------MKSQGQHWYSSS-DKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF P_pygmaeus_ENSPPYP00000003106 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000021726 -----------------------------------------MTSQGQNLNSSS-DDNCTMDFRQKLLFIDSHLGDQDVERLRFLCRDCVSHKKLEKSSSALEIFNHLLAEDLLREEDSFF G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048878 -----------------------------------------MKSQGQHWCSSS-DKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVP-KKLEKSSSASDVFEHLLAEDLLSEDDPFF A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014602 -----------------------------------------MKSQGQHWCSSS-DKNCKVSFREKLLIIDSNLGVQDVENLKFLCVGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFF G_aculeatus_ENSGACP00000005791 -----------------------------------------------------------MHFQKLLFDIGKALSGEEVKALAFLCTDILG-RNLSSVESASGLFSRLRDQGFLSAEQPHL O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014046 ------------------------------------------------------------MDRRTLSRIDDELNSEEVAELCFLCTDFIPRKRLEGISSAKDLFLKLEDATLL---DSSY D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 -----------------------------------------MR----------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004754-PA --------------------------------------------------------------------------------------------------------MNNKDRFLITHNVEKL G_aculeatus_ENSGACP00000016983 ----------------------------------------------------------------------------------------------------------MSARGKVRSQKTAI M_domestica_ENSMODP00000034022 --------------------------------------------------------------------------------------------------------LTDKVLMEKRRLFVES D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034033 --------------------------------------------------------------------------------------------------------LTDKVLKEKRRLFVES T_rubripes_ENSTRUP00000024164 -------------------------------------------------------------------------------------------------------VFLPKDMEAVRRNKTAI D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017024 ---------------------------------------------------------------------------------------------------------LAAQLKKVRKLFIDG C_familiaris_ENSCAFP00000017933 -----------------------------------------MTSQAQSLTFRS-DDNCQSSFRGKLLTIDSKLEIQDVEGLKFLCRDFVSHKKLEKSNSASDIFDHLLAEELLSEEDPFF O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075650 -------------------------------------------------------------------------------------------------------MDKKESVDKICENKIFL O_cuniculus_ENSOCUP00000013793 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036251 -----------------------------------------M------------EDNSKIKFNQQLLSINEKLEPEEIEALKFLCSDLISPRNLEDIESGHQLFQKFMDEDLLNEGDYFL X_tropicalis_ENSXETP00000008971 -----------------------------------------------------------MDFNSMLLSIDDGLGREDIEALKFLCRDVLRKNKLLSVRSGQELFQQLMTEDLINEDNFFL D_rerio_ENSDARP00000095527 ------------------------------------------------------------MDPQIFHEIDENLTSGDVDQLKFLCLDFIPKRRLESVTDAKDLILRLDEQGLLEDE--LL T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ 130 140 150 160 170 180 190 200 210 220 230 240 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000083664 LQDLVVDD--LLIQCLQQ-----------------------------------------------------------------------------------------------------D G_aculeatus_ENSGACP00000013740 CKQLVVDE--LLIQSLQT-----------------------------------------------------------------------------------------------------D O_latipes_ENSORLP00000015114 LKDLVVDE--LLIQALVK-----------------------------------------------------------------------------------------------------D T_rubripes_ENSTRUP00000037606 CKQLVVDE--LLIQCLQA-----------------------------------------------------------------------------------------------------D T_nigroviridis_ENSTNIP00000010874 FKQLVVDE--LLIQFLQA-----------------------------------------------------------------------------------------------------D G_gallus_ENSGALP00000029853 ARELVLKE--LMEHMIEK------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000013612 AKQLVLNV--LVEHMVEK------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000006831 AKQLVLKE--LMEHLIEK------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000003321 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000031895 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022672 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000024166 AKELLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000020323 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000015203 LHDMIIEE--LVEHLVSS------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000312664 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000033921 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000005409 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000016588 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000001598 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000005545 AKQLMLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000001859 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000002956 AKCLHLDE--VLQYLVQC------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000007986 CKELVVDE--LLQELIGE------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000003520 AKQLLLSE--LLEHLLEK------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000015596 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000017449 VAALRVEP--LWEPLEQR------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000047019 VKALNPED--VCDKLLSK------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000004412 VCELQVEP--LWDLMLDR------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000002083 VEGLRPEV--LWGPLQAR------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000007379 VRDLDPSS--LYDGLLEK------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000003205 VGELQVAS--LWDALLSR------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000002138 VEELQVDQ--LWDALLSR------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000365051 VEELQVDQ--LWDALLSR------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000056642 VEELQVDQ--LWDALLSR------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000040583 VEELQVDQ--LWDALLSR------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000045375 VGELDPSS--LYDGLIEK------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000030747 VSELQVAE--LWDALLSR------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000015102 VRELQVDS--LWDALLTR------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000013855 VSELEPLN--LYDGLIEK------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000023986 VRELQVAA--LWDALLSR------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075318 LSERVING--LLDDLQQK------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000015721 VKELRVDP--LWDLLLQE------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000001216 LSELLSII--QRTRLLRD-LDLRSSATSNL----------ISAY--------------------------------R------------------------------------KLLYSLS R_norvegicus_ENSRNOP00000017972 VRELQVAE--LWDALLSR------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036247 LKELLFRI--NRIDLLNEPLNTKGPEMERELQV--PNKARISPY--------------------------------RLHLHTTIWPFRDNWTCRITLSVSFTSRTKQLLSVMVILLFNLS C_elegans_C48D1.2 SSHLKVDE--ILEVLIAK------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000003208 VKELDLSD--LCDVLLRK------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000001932 ------------------------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017899 LKELLFRI--NRLDLLMTYLDTSKEDMQQELQI--PGRAQISAY--------------------------------R------------------------------------VMLFQIS R_norvegicus_ENSRNOP00000016613 LKELLFHI--SRRDLLSRVLKSSPEEMVRELQV--LGKAQVSAY--------------------------------R------------------------------------VMLFKLS M_musculus_ENSMUSP00000027189 LKELLFHI--SRWDLLVNFLDCNREEMVRELRD--PDNAQISPY--------------------------------R------------------------------------VMLFKLS T_rubripes_ENSTRUP00000024467 LSQLLHTI--HRKDLLCL-LEADSSQPEET-----DARPLLSEYR--------------------------------------------------------------------VMLYKLY T_guttata_ENSTGUP00000006879 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000038128 LKELLFRV--NRLDLLLNYLYTSEEEMKRELQI--PGRAQISAY--------------------------------R------------------------------------ILLFQIS T_rubripes_ENSTRUP00000040691 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013506 LAELLYRI--KYHSLLSK-LGYTKEKVQECL----HEKGKVSPY--------------------------------R------------------------------------QMLYELS G_gallus_ENSGALP00000017288 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000006164 LKELLFRI--HRLDLLSTLLGTSKEEMVTELQI--PGRAHISAY--------------------------------X------------------------------------XXXXXXX T_guttata_ENSTGUP00000004278 ------------------------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0084848 ------------------------------------------------------------------------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037892 LKELLFRI--NRLDLLTTYLNTRKEEMERELQA--PGRAQISAY--------------------------------R------------------------------------VMLYQIS O_anatinus_ENSOANP00000006351 LKELLFRI--HRIDLLTSHLRTSQEDVARELEE--PGRAQVSAYS-------------------------------R------------------------------------VLLFTLS T_guttata_ENSTGUP00000010625 LKELLYRI--HRIDLLSTPLGCSREEMERELQL--PGRAQVSAY--------------------------------R------------------------------------QLLYGIA C_familiaris_ENSCAFP00000032189 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000010722 LRQLLQTI--RREDLLRL-LGADNRQLMET-----DASPLLSGYS--------------------------------------------------------------------VMLYNIY P_pygmaeus_ENSPPYP00000017020 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000005556 ------------------------------------------------------------------------------------------------------------------------ A_aegypti_AAEL014348-PA ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000008706 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000000517 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000001629 VAELLYRI--KCHFLLQK-IGYTQQKVEHNL----FHIRNVSEY--------------------------------R------------------------------------QMLYEIS M_domestica_ENSMODP00000005560 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP000830-PA ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000010095 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000311032 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000022693 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000015808 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000054330 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000091238 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000031759 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000004055 LKELLFRI--NRLDLLTTELDTSKEEMERELQS--PGRAQISAY--------------------------------R------------------------------------VMLFQIS T_nigroviridis_ENSTNIP00000022078 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013731 ------------------------------------------------------------------------------------------------------------------------ M_musculus_ENSMUSP00000026062 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000001627 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000351273 LKELLFRI--NRLDLLITYLNTRKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQIS D_rerio_ENSDARP00000063081 IDTLSVEASFILQNVQQA------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000013591 LKELLYRI--NRIDLLASYLGSSREEMERELQV--PGRARVSPF--------------------------------R------------------------------------YLLFQLS G_aculeatus_ENSGACP00000024809 ------------------------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000044662 LVELLGII--QRTKLLRD-HNLPRTGAQDL----------ISPYSCKS----------------------------R------------------------------------KLLYSLS X_tropicalis_ENSXETP00000003217 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP009832-PA ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000021879 LKELLFRI--NRLDLLITYLNTRKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQIS D_rerio_ENSDARP00000019984 --------------------MDKEA----------------------------------------------------------------------------------------LTSENEV G_gorilla_ENSGGOP00000000205 LKELLFRI--NRLDLLITYLNTRKEEMERELQT--PGRAQISAY--------------------------------R------------------------------------VMLYQIS C_familiaris_ENSCAFP00000016420 ------------------------------------------------------------------------------------------------------------------------ R_norvegicus_ENSRNOP00000014096 ------------------------------------------------------------------------------------------------------------------------ T_nigroviridis_ENSTNIP00000009934 ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014606 LKELLFRI--NRLDLLITYLNTRKEEMERELQT--PGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWWRVDHILIR------------------------------------VMLYQIS H_sapiens_ENSP00000358327 ---------------------------------------------------------------------------------------------------------------------MDC P_troglodytes_ENSPTRP00000005216 ---------------------------------------------------------------------------------------------------------------------MDC X_tropicalis_ENSXETP00000035938 ------------------------------------------------------------------------------------------------------------------------ H_sapiens_ENSP00000286186 LAELLYII--RQKKLLQH-LNCTKEEVERLL----PTRQRVSLF--------------------------------R------------------------------------NLLYELS P_pygmaeus_ENSPPYP00000003106 ---------------------------------------------------------------------------------------------------------------------MDC E_caballus_ENSECAP00000021726 LAELLYII--KQKSLLCH-LCYTKEQVESLL----PARRRVSLF--------------------------------R------------------------------------NLLYELS G_aculeatus_ENSGACP00000024816 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000002670 ------------------------------------------------------------------------------------------------------------------------ T_guttata_ENSTGUP00000011206 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004920-PA ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000014503 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000008661 ------------------------------------------------------------------------------------------------------------------------ P_troglodytes_ENSPTRP00000048878 LAELLYII--RQKKLLQH-LNYTKEEVERLL----PTRQRVSLF--------------------------------R------------------------------------NLLYELS A_gambiae_AGAP011951-PA ------------------------------------------------------------------------------------------------------------------------ P_pygmaeus_ENSPPYP00000014602 LAELLYII--RQKKLLQH-LSYTKEEVEGLL----PTRQRVSLF--------------------------------R------------------------------------NLLYELS G_aculeatus_ENSGACP00000005791 LTELLIII--QRVRLTRD-VDLPAE-----------PSSLISPY--------------------------------R------------------------------------KMLYNLS O_latipes_ENSORLP00000010793 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075645 ------------------------------------------------------------------------------------------------------------------------ O_latipes_ENSORLP00000014046 LTQLFRTI--HREDLVRQ-VQNGSRQAEEA-----DAVPSLSDYR--------------------------------------------------------------------VMLYSIH D_rerio_ENSDARP00000006831 ------------------------------------------------------------------------------------------------------------------------ M_mulatta_ENSMMUP00000037898 ------------------------------I----PTKW--------------------------------------------------------------------------------- O_cuniculus_ENSOCUP00000009498 ------------------------------------------------------------------------------------------------------------------------ A_gambiae_AGAP004754-PA VNYTNYKQ--LSFECIQQ------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000016983 HEALCADYSLILNKVFEK------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034022 VDRGVMNG--LLDDLLEV------------------------------------------------------------------------------------------------------ D_melanogaster_FBpp0071971 ------------------------------------------------------------------------------------------------------------------------ G_gorilla_ENSGGOP00000007184 ------------------------------------------------------------------------------------------------------------------------ A_carolinensis_ENSACAP00000012644 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000034033 VDRGVING--LLDDLLEL------------------------------------------------------------------------------------------------------ T_rubripes_ENSTRUP00000024164 GTIFCADYGLILNKVDEK------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000071815 ------------------------------------------------------------------------------------------------------------------------ B_taurus_ENSBTAP00000021099 ------------------------------------------------------------------------------------------------------------------------ X_tropicalis_ENSXETP00000017024 CNAAIINN--LLDDLLDK------------------------------------------------------------------------------------------------------ C_familiaris_ENSCAFP00000017933 LAELLYII--KQNSLLRY-LNQSKEQVESLL----PTRRRVSLF--------------------------------R------------------------------------NLLYELS O_anatinus_ENSOANP00000005531 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000024255 ------------------------------------------------------------------------------------------------------------------------ D_rerio_ENSDARP00000075650 LETLSVDANFILQHVQQA------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000013793 ------------------------------------------------------------------------------------------------------------------------ G_gallus_ENSGALP00000019870 ------------------------------------------------------------------------------------------------------------------------ O_anatinus_ENSOANP00000002508 ------------------------------------------------------------------------------------------------------------------------ O_cuniculus_ENSOCUP00000003895 ------------------------------------------------------------------------------------------------------------------------ M_domestica_ENSMODP00000036251 VAELLFLI--KHHNLLQK-IGYTKEKVKKEL----SSKRKISSY--------------------------------R------------------------------------VMLYNLS X_tropicalis_ENSXETP00000008971 LKELLYII--NHHSLLRN-LGTNKEKVQKAL----PRQGRISPYR--------------------------------------------------------------------QMLYQLS D_rerio_ENSDARP00000095527 FPELLITI--GRIDLLEI-LKKSKEEVKRNLLRCDNSRKGVSAYR--------------------------------------------------------------------KMLLKIS T_rubripes_ENSTRUP00000022652 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000024812 ------------------------------------------------------------------------------------------------------------------------ G_aculeatus_ENSGACP00000022402 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000013268 ------------------------------------------------------------------------------------------------------------------------ 250 260 270 280 290 300 310 320 330 340 350 360 =========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+=========+ D_rerio_ENSDARP00000083664 GILTDSMAESIMAKPTS-Q--GRSHQLLFLLPKRGPRAFSTFCSALKETEQHHLCKLLMDFTE--------------------------------------KDKKNSQYKL--------- G_aculeatus_ENSGACP00000013740 EILTEAMAENIMAEQTS-Q--KRSWRLLLLLPKRGPRAFSSFCSALQETEQQHLYELLIQSSE--------------------------------------KDGKETPGML-----MCGQ O_latipes_ENSORLP00000015114 GILTQNMAESIMVQKTS-H--HRSFKLLLLLPKRGPRAFKSFCSALKETEQEHLCDLLTQE----------------------------------------EEGREVCLDTPLINSEEQS T_rubripes_ENSTRUP00000037606 DILTESMAESIMAEQTS-Q--KRSWRLQLLLPKRGPKAFSSFCSALRATDQQHLCDLLTQTFE--------------------------------------TNGNGT---------HVET T_nigroviridis_ENSTNIP00000010874 DILTDSMAESILAEQTS-H--KRCWKLLHLLPKRGPKAFSSFCSALRETDQKHLCDLLARTSQ--------------------------------------ENGNGT---------HLET G_gallus_ENSGALP00000029853 DIITIEMVEMIQAKSGS-F--SQNVEFLNLLPKRGPNAFSAFCEALQETKQQHLAEMILKTESS--------------LRHG--IAT------------------------------LEQ T_guttata_ENSTGUP00000013612 DIIPTEMVEMIQAKSGS-F--DRNVEFLNLLPKRGPNAFSAFCEALRETQQQHLETLILKTMSS--------------LSQE--IAR------------------------------LEH A_carolinensis_ENSACAP00000006831 DVITEEMMEMIQAKAGN-F--SQNIEFLNLLPKRGPKAFSAFCEALRETKQPHLEEMLLLNLIDFL------------LFHHVIVPP--------------------------------- E_caballus_ENSECAP00000003321 DIITLEMRELIQAKVTS-F--GQNVELLNLLPKRGPQAFEAFCVALRETKQGHLEDLLLTTLSG--------------LQHV--LPP------------------------------LSC M_musculus_ENSMUSP00000031895 DIITLEMRELIQAKGGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSD--------------IQHV--LPP------------------------------LSC R_norvegicus_ENSRNOP00000022672 DIITLEMRELIQAKGGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSD--------------IQHI--LPP------------------------------LSC B_taurus_ENSBTAP00000024166 DIITLEMREHIQAKTGS-F--GQNVELLNLLPKRGPQAFDAFCVALRETKQSHLEELLLRTLSG--------------LQPV--VPP------------------------------LSC P_pygmaeus_ENSPPYP00000020323 DIITLEMRELIQAKVGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSG--------------LQHV--LPP------------------------------LSC X_tropicalis_ENSXETP00000015203 GILTPIMHSTIMAHRSE-Y--KQNVTLLTQLPKRGPRAFSEFCNALHATGQRHLAEQLEEEAQ---------------QQQMESVTP--------------------------------E H_sapiens_ENSP00000312664 DIITLEMRELIQAKVGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSG--------------LQHV--LPP------------------------------LSC P_troglodytes_ENSPTRP00000033921 DIITLEMRELIQAKVGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSG--------------LQHV--LPP------------------------------LSC C_familiaris_ENSCAFP00000005409 DIITLEMREHIQAKVGG-F--SQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTLSG--------------LQHG--LPP------------------------------LSC M_mulatta_ENSMMUP00000016588 DIITLEMRELIQAKVGS-F--SQNVELLNLLPKR-PQAFDAFCEALRETKQGHLEDIELKLRVS--------------ALMK--PTG------------------------------LGS M_domestica_ENSMODP00000001598 DIITLEMRELIQAKVGS-F--SQNVEFLNLLPKRGPHAFEAFCDALRETKQGHLEDLLHRTLYS--------------FQNL--RPP------------------------------LGC O_anatinus_ENSOANP00000005545 DVITMEMRELIQAKAGS-F--SQNVEFLNLLPKRGPKAFDAFCAALRETKQGHLQDLLYRTLSN--------------LS-----PPS-------------TAVGALGTQGEELAGRLGG O_cuniculus_ENSOCUP00000001859 DIITLEMRELIQARVGS-F--SQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTLSG--------------LQHV--LPP------------------------------LSC C_intestinalis_ENSCINP00000002956 GILTDVTVERITSKPTR-F--SQNVAFLTCLPTRGPRAYGTFLEALRISSQEHLVDILEKVDISNA------------IPNNKPITPTTLHATITSNVHSEFVCARRQPMEIGKCED--- C_intestinalis_ENSCINP00000007986 GIFNDILADRVLSHQRDF---KKNVEFLTLLPGRGPNAFNAFRIALINSDQSHLAELLDPAQGVSQPNESNANDGSGGPELSASIFRFESIATANSNLPGTSGTSAPLSRRRPMENTDQS G_gorilla_ENSGGOP00000003520 DIITLEMRELIQAKVGS-F--SQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSG--------------LQHV--LPP------------------------------LSC O_anatinus_ENSOANP00000015596 ---------------AG-TRRDQARQLVTDLETRGRRALSVFISCLRETDQHALAALLSEG-----------------CQAPQVTPVD--------------------------IRPVEI T_guttata_ENSTGUP00000017449 GLFTRPMLEELQS--AG-SRGEQARQLIIDLETRGKQAFPAFLSILRDTGQGHLAEMLMQE-----------------CESRPVPPQLPD------------------------LRPVEL D_rerio_ENSDARP00000047019 GVFTQDMIDEIQS--KA-TRRDQARQLVKDLETRGSLAFPAFLDSLRETGHNDLAELLQSGDGVHR------------PPVISVQPSPI-------------------------PLPVQN M_domestica_ENSMODP00000004412 ELFTRDMIEDIQR--AG-TRRDQARQLVTDLQTRGKRALPIFISCLEATGQWDLAALLSES-----------------NTTLTQQPDPID------------------------IKPVEM G_gallus_ENSGALP00000002083 GVFTSAMVEDMQS--TG-TRREQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEG-----------------CGSPMSPPVD--------------------------LRPVQL G_aculeatus_ENSGACP00000007379 GVFTQDMIDEIKS--AG-TRRDQARKLVQDLETRGSRAFAMLLLCLEETDQHGLAELLQRA-----------------APAVQIWPAA--------------------------P---NQ B_taurus_ENSBTAP00000003205 ELFTPDMIEDIQRAGSG-SRRDQARQLILDLETRGSQALPLFISCLEDTGQDTLASLLKTS-----------------RQAAKQ------------------------------------ P_pygmaeus_ENSPPYP00000002138 ELFRPHMIEDIQRAGSG-SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTN-----------------RQAAKL------------------------------------ H_sapiens_ENSP00000365051 ELFRPHMIEDIQRAGSG-SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTN-----------------RQAAKL------------------------------------ P_troglodytes_ENSPTRP00000056642 ELFRPHMIEDIQRAGSG-SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTN-----------------RQAAKL------------------------------------ M_mulatta_ENSMMUP00000040583 ELFKPHMIEDIQRAGSG-SRRDQARQLITDLETRGSQALPSFISCLVDTGQDMLASFLRTN-----------------RQAVKL------------------------------------ T_rubripes_ENSTRUP00000045375 RVFTHDMIDEIKS--SG-TRRDQARQLIRDLETRGSRAFPLFLECLQETGHHTLVELLQDG-----------------GPAVQIQPPT--------------------------PVPIDR M_musculus_ENSMUSP00000030747 ELFTRDMIEDIQQAGSG-SRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSG-----------------RQAAKQDPEA--------------------------VKPLDH E_caballus_ENSECAP00000015102 ELFTPDMIEDIQR--SG-SRRDQARQLIIDLETRGSQALLLFISCLEDTGQDTLASFLRTS-----------------SQAAKQNPEA--------------------------IRPSD- T_nigroviridis_ENSTNIP00000013855 GVFTHDMIDEIKC--SG-ARRDQARQLVRDLETRGSRAFPAFLECLKETGYHSLAELLQNG-----------------APTVQIQPPT--------------------------PIPVDR C_familiaris_ENSCAFP00000023986 ELFTAAMVEDLQHAGSG-SRSDQARQLVIDLETRGSQALPLFISCLEDTGQDALASCLTMS-----------------RQAVKQNPEA--------------------------TRPLD- D_rerio_ENSDARP00000075318 KVFGEEEIEDIQHRMKT-RA-DQARHVIDDVKRKGVKASEIMLASLKTRDPHLYDTLGIERL---------------------------------------------------------- A_carolinensis_ENSACAP00000015721 GIFSQDMIEEIQG--SG-ARSAQARQLCIDLETRGKRALPVFVHCLQETGQGALADLLGRGA----------------NQVPESLSDHI------------------------------- T_nigroviridis_ENSTNIP00000001216 EDLTDDNLKEIKFLLT--E--TLPRRKLEDNVT--TLEVFLELECMDLLSKTNLGLLKSILQP-VC------------PVLAERIRQFE------------AQN---------------- R_norvegicus_ENSRNOP00000017972 ELFTRDMIEDIQRAGSG-SRRDQARQLVIDLETRGRQALPRFISCLEDTGQGSLASFLQSS-----------------GQAAKQDPEA--------------------------VTPLDH M_domestica_ENSMODP00000036247 EGVGPSELKSIKFMLS--S--KIPKCKIEDDMT--LMDLFIEMEKRGILGEGNLDALKIVCDQ-ID------------KSLLKKIQEYE------------ISKGRNNLF---------- C_elegans_C48D1.2 QVLNSDNGDMINSCGTV-R--EKRREIVKAVQRRGDVAFDAFYDALRSTGHEGLAEVLEPLARSVD------------SNAVEFECPMS------------PASHRRSRALSPAGYTSPT O_latipes_ENSORLP00000003208 DVFTQSMINDIKRQNCE-TKRDQARKLVKDLETRGNEAFSAFLEGLRVTGQQNLLELLQKS-----------------APRVHFQPGK--------------------------STEAGY G_gorilla_ENSGGOP00000001932 ------------RAGSG-SRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTN-----------------RQAAKL------------------------------------ C_familiaris_ENSCAFP00000017899 EDVSKLELKSFKFLLS--R--EISRCKLDDDLN--LLDIFIEMEKRVILGERNLDTLKRICDQ-IN------------KSLLKKITDYE------------ELNREQTMN---------- R_norvegicus_ENSRNOP00000016613 EDMDKEDLKSFKFLLI--T--EIPKCKLQDNSS--LLDIFVEMEKRTILAENNLVTLKSICFR-VN------------RSLLGRIDDYE------------RSSTERRMS---------- M_musculus_ENSMUSP00000027189 EEVSELELRSFKFLLN--N--EIPKCKLEDDLS--LLEIFVEMEKRTMLAENNLETLKSICDQ-VN------------KSLLGKIEDYE------------RSSTERRMS---------- T_rubripes_ENSTRUP00000024467 ENLDREDLKKLKFLLSD----QLGRRQIELCKT--VLDVFTEMEKKGLLSNTKLDKLHSVLKE-VD------------QRLAATVHDFM------------QPLRGILVP---------- T_guttata_ENSTGUP00000006879 ---------------------------------------MTDIGDGAHLGKDLADTKSIPGF---------------------------------------------------------- B_taurus_ENSBTAP00000038128 EDVNKVELKDFKFFLS--Q--EIAKCKLDDDMT--LLDIFVEMEKRTILGEENLDTLKRICEQ-VN------------KSLLKKIYDYE------------ELRKERRMS---------- T_rubripes_ENSTRUP00000040691 ---------------------------------------TNMSANGPSPGGDFTDAKKGAGQQ--------------------------------------------------------- G_gallus_ENSGALP00000013506 ENITNDMLQEIVFLLRN----HLPKRR----RTISALELLILLEKQCLLTENNVQILEEVFRN-VS------------PDLLETVKCYR------------MAKVALPHQ---------- G_gallus_ENSGALP00000017288 --------------------------------------MMTDIKDGPRSGEDVSDARSFPGS---------------------------------------------------------- O_cuniculus_ENSOCUP00000006164 XXXXXXXXXXXXXXXX--X--XXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXX-XX------------XXXXXXXXXXX------------------------------- T_guttata_ENSTGUP00000004278 --------------------MSGSERRPPAGHVQLDSRPTLPTT-DGNENITEVDALNIR------------------------------------------------------------ D_melanogaster_FBpp0084848 ---------------------MDATNNGESADQVGIRVGNPEQPNDHTDALGSVGSGGAGSSGLVA------------------------------------------------------ C_intestinalis_ENSCINP00000003204 ------------------------MSLKSAADVLMSGVPTPHTNENNNVGQSEVDALGSGETP--------------------------------------------------------- M_mulatta_ENSMMUP00000037892 EEVGRSELRSFKFLLQ--E--EISKCKLDDDMN--LLDIFVEMEKRVILGEGKLDILKRVCAQ-VN------------KSLLKIINDYE------------EFSRERTRS---------- O_anatinus_ENSOANP00000006351 DNVTREELKSITFFLS--N--DLPRSRLDNKQT--LMGIFIEMEKKGILGESNLDMLKKICDK-ID------------KTLLGKIDHYE------------ERRADCTLH---------- T_guttata_ENSTGUP00000010625 EDLTSEDVRSVKFLLQ--K--QLPKNKLQENAS--MLQVFLEMEIKGIIKEDNMTTLKDILQR-FR------------ADIKKKIDAYE------------EKKKGLTGS---------- C_familiaris_ENSCAFP00000032189 ------------------MGEQRNTSSKELAAAEATGQSGKELEVSMENTENSVDAKSFKNA---------------------------------------------------------- T_nigroviridis_ENSTNIP00000010722 EDLCKEDLGKIKFFLGD----KLGRRPTEMCKT--VLDVFAEMEKKGFLSEIYLDELHSVLQN-VN------------PLLASKVQQHM------------QHLRDNHRP---------- P_pygmaeus_ENSPPYP00000017020 ----------------------------------------------MENTENSVDSKSIKNL---------------------------------------------------------- M_domestica_ENSMODP00000005556 ----------------------------------------------MEDTGTTVDAKSTKNS---------------------------------------------------------- A_aegypti_AAEL014348-PA -------------------------------------------MKKIMFGRKEVNSPQ-------------------------------------------------------------- B_taurus_ENSBTAP00000008706 --------------------------------------------------------------------------------S-K------------------------------------- O_anatinus_ENSOANP00000000517 ----------------------------------------------AASGEVMVDSKSFHSSQ--------------------------------------------------------- A_carolinensis_ENSACAP00000001629 EGFTEENVKTAMFLLR--E--HLPKKQ----SI--AVKLLTSLEKQDLLAEDKLAILEKICNK-VS------------PELRNKVDKFK------------ERSVFKAFV---------- M_domestica_ENSMODP00000005560 ----------------------------------------------MEDTGTTVDAKSIKNS---------------------------------------------------------- A_gambiae_AGAP000830-PA ------------------MSMPDVVDIRNEINKEHVRESLDRNGDEQQLVQDVNDALGTRKGHD-------------------------------------------------------- O_latipes_ENSORLP00000010095 -------------------------------------------MASNRPGEDSTDARKDNGEL--------------------------------------------------------- H_sapiens_ENSP00000311032 ----------------------------------------------MENTENSVDSKSIKNL---------------------------------------------------------- R_norvegicus_ENSRNOP00000022693 --------------------------------MTDDQDCAAELEMADSSTEDGVDAKPDRSTIISS------------LLW-K------------------------------------- M_mulatta_ENSMMUP00000015808 ----------------------------------------------MENTENSVDSKSIKSL---------------------------------------------------------- P_troglodytes_ENSPTRP00000054330 ----------------------------------------------MENTENSVDSKSIKNL---------------------------------------------------------- M_musculus_ENSMUSP00000091238 ----------------------------------------------MENNKTSVDSKSINNF---------------------------------------------------------- T_rubripes_ENSTRUP00000031759 --------------------------SMQMAGEPTEISDLGGEVEEGGQSEDDVDAKPDRKGRFLL------------FKS-K------------------------------------- E_caballus_ENSECAP00000004055 EDVNKLELKSFKFLLS--R--ELPKCRLDDDMI--LLDIFIEMEKRVMLGERNLDTLKKICEQ-VN------------KSLLKKINDYE------------ELSREGRIS---------- T_nigroviridis_ENSTNIP00000022078 -----------------------------MAGEAAGIPELGGEAEGEHRCEDDVDAKPDRRGRFLL------------FKS-K------------------------------------- E_caballus_ENSECAP00000013731 --------------------------------MADDQDCVVEQGAGDSTSTDAVDAKPDRSSFVPS------------LFS-K------------------------------------- M_musculus_ENSMUSP00000026062 --------------------------------MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISS------------ILL-K------------------------------------- M_mulatta_ENSMMUP00000001627 --------------------------------------------------------------------------------S-K------------------------------------- A_carolinensis_ENSACAP00000009923 ------------------------------------------------------------------------------------------------------------------------ E_caballus_ENSECAP00000019797 ----------------------------------------------MENSKISVDSKSIKNS---------------------------------------------------------- H_sapiens_ENSP00000351273 EEVSRSELRSFKFLLQ--E--EISKCKLDDDMN--LLDIFIEMEKRVILGEGKLDILKRVCAQ-IN------------KSLLKIINDYE------------EFSKERSSS---------- D_rerio_ENSDARP00000063081 KLITQRDYNNLSDVS---ERETKIIKLLDKLIGRGEETCQEFIDLLRQDCVLENFPVLEGH----------------------------------------------------------- G_gallus_ENSGALP00000013591 ENITKDDMKCFKFLLG--K--ELPKCKL